LOCUS       DAVHIZ010000001       108913 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.001, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000001 DAVHIZ010000000
VERSION     DAVHIZ010000001.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 108913)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 108913)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..108913
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.001"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..116)
                     /locus_tag="VVO18_000001"
     CDS             complement(<1..116)
                     /locus_tag="VVO18_000001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine ABC transporter permease"
                     /protein_id="HEU5585233.1"
                     /translation="MKKLYRIHFIAIAVIDLLLFAFFIPNHSYLSQLDVTYKT"
     gene            complement(247..893)
                     /locus_tag="VVO18_000002"
                     /pseudo
     CDS             complement(247..893)
                     /locus_tag="VVO18_000002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819460.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide mononucleotide transporter"
     gene            complement(919..1110)
                     /locus_tag="VVO18_000003"
     CDS             complement(919..1110)
                     /locus_tag="VVO18_000003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585234.1"
                     /translation="MSRKSTNFSSPLPTLKVLFSGFYFYHFILLSFGGRIFEKNGRVF
                     EKKKGSLTYEKITKNFCYI"
     gene            complement(1091..1741)
                     /locus_tag="VVO18_000004"
     CDS             complement(1091..1741)
                     /locus_tag="VVO18_000004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000188500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="HEU5585235.1"
                     /translation="MTPNKEDYLKCIYEIGIDLHKITNKEIAARMQVSPPAVTEMIKR
                     MKSENLILKDKECGYLLTDLGLKLVSELYRKHRLIEVFLVHHLDYTSDQIHEEAEVLE
                     HTVSDLFVERLDKLLGFPKTCPHGGTIPAKGELLVEINNLPLADIKEAGAYRLTRVHD
                     SFDILHYLDKHSLHIGDQLQVKQFDGFSNTFTILSNDEDLQVNMDIAKQLYVEKIN"
     gene            1853..2695
                     /locus_tag="VVO18_000005"
     CDS             1853..2695
                     /locus_tag="VVO18_000005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEU5585236.1"
                     /translation="MTKIALLSDIHGNTTALEAVLADARQIGVDEYWLLGDILMPGTG
                     RRRILDLLDQLPITARVLGNWEDSLWHGVRKELDSTRPSQRYLLRQCQYVLEEISLEE
                     IEVLHNQPLQIHRQFGDLTVGISHHLPDKNWGRELIHIGKQEEFDRLVTHPPCDIAVY
                     GHIHQQLLRYGTGGQLIVNPGSIGQPFFLDAQLRKDLRAQYMILEFDDKGLVDMDFRR
                     VDYDVAAELQLAKDLRLPYFEVYYESLVNGIHHTHHQEFLRELAQKEGCDRELDDWLK
                     SGND"
     gene            2771..3208
                     /locus_tag="VVO18_000006"
     CDS             2771..3208
                     /locus_tag="VVO18_000006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004263219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="HEU5585237.1"
                     /translation="MQIPSRFTIATHMLIIIALEGKESKVTSDFLAASVGVNPVIIRK
                     ILSQLKKAELISVARGTGGTEIVKDLKDISLLDVYQAVECLGKTGQLFSFHDNPNPNC
                     PVGAHIHDVLDQKLERIQLTMEAELGQISLEKVVADAESQMKD"
     gene            3276..3578
                     /locus_tag="VVO18_000007"
     CDS             3276..3578
                     /locus_tag="VVO18_000007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000281600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585238.1"
                     /translation="MYLVIGIVLAFIVSFWKDNRSLWNPVLFLLSLISSYFYLSYLFY
                     KNGYENVQLAFYVFAFVLLPFLLFLSGIFLIYNGVILLKREGRSKPNYLSMLFDFY"
     gene            complement(3669..4742)
                     /locus_tag="VVO18_000008"
     CDS             complement(3669..4742)
                     /locus_tag="VVO18_000008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2974 domain-containing protein"
                     /protein_id="HEU5585239.1"
                     /translation="MANIFDYLKDVAYDSYYDLPLNELDILTLIEITYLSFDNLVSTL
                     PQRLLDLAPQVPRDPTMLTSKNRLQLLDELAQHKRFKNCKLSHFINDIYPELQKQFAA
                     MTYRVSLDTYLIVFRGTDDSIIGWKEDFHLTYMKEIPAQKHALRYLKNFFAHHPKQKV
                     ILAGHSKGGNLAIYAASQIEQSLQNQITAVYTFDAPGLHQELTQTAGYQRIMDRSKIF
                     IPQGSIIGMMLEIPAHQIIVQSTALGGIAQHDTFSWQIEDKHFVQLDKTNSDSQQVDT
                     TFKEWVATVPDEELQLYFDLFFGTILEAGISSINDLASLKALEYIHHLFVQAQSLTPE
                     ERETLGRLTQLLIDTRYQAWKNR"
     gene            4898..5575
                     /locus_tag="VVO18_000009"
     CDS             4898..5575
                     /locus_tag="VVO18_000009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585240.1"
                     /translation="MHKILLIEDDQVIRQQVGKMLSEWGFEVVLVEDFMEVLSLFVQS
                     EPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSSRDQAMDIVMAINMGADDFVTKP
                     FDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
                     RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGI
                     GYGLKHA"
     gene            5568..6542
                     /locus_tag="VVO18_000010"
     CDS             5568..6542
                     /locus_tag="VVO18_000010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEU5585241.1"
                     /translation="MLDWKQFFLAYLRSRSRLFIYLLSLAFLVLLFQFLFASLGIYFL
                     YFFFLCCFVTILFFTWDILVETQVYRQELLYGEREAKSPLEIALAEKLEAREMELYQQ
                     RSKAERKLTDLLDYYTLWVHQIKTPIAASQLLVAEVVDRQLKQQLEQEIFKIDSYTNL
                     VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLHDLDKEIVTDKKW
                     LLVVIEQIISNSLKYTKEGGLEIYMDDQELCIKDTGIGIKNSDVLRVFERGFSGYNGR
                     LTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTTVRIQFAQVNLVLE"
     gene            complement(6591..8534)
                     /gene="thrS"
                     /locus_tag="VVO18_000011"
     CDS             complement(6591..8534)
                     /gene="thrS"
                     /locus_tag="VVO18_000011"
                     /EC_number="6.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000608363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine--tRNA ligase"
                     /protein_id="HEU5585242.1"
                     /translation="MINITFPDGAVREFESGVTTFEIAQSISNSLAKKALAGKFNGKL
                     IDTTRAITEDGSIEIVTPDHEDALPILRHSAAHLFAQAARRLFPDIHLGVGPAIEDGF
                     YYDTDNTAGQISNEDLPRIEEEMQKIVKENFPSIREEVTKDEAREIFKNDPYKLELIE
                     EHSEDEGGLTIYRQGEYVDLCRGPHVPSTGRIQIFHLLHVAGAYWRGNSDNAMMQRIY
                     GTAWFEKKDLKNYLQMREEAKERDHRKLGKELDLFMISQEVGQGLPFWLPNGATIRRE
                     LERYIVNKELASGYQHVYTPPLASVELYKTSGHWDHYQEDMFPTMDMGDGEEFVLRPM
                     NCPHHIQVFKHHVHSYRELPIRIAEIGMMHRYEKSGALTGLQRVREMSLNDGHLFVTP
                     EQIQEEFQRALQLIIDVYEDFNLTDYRFRLSLRDPQDTHKYFDNDEMWENAQTMLRAA
                     LDEMGVDYFEAEGEAAFYGPKLDIQIKTALGKEETLSTIQLDFLLPERFDLKYIGADG
                     EDHRPVMIHRGVISTMERFTAILIENYKGAFPTWLAPHQVTLIPVSNEKHVDYAWEVA
                     KKLRDRGVRADVDERNEKMQFKIRASQTSKIPYQLIVGDKEMEDETVNVRRYGQKETQ
                     TVSVDNFVQAILADIANKSRVEK"
     gene            complement(8592..8915)
                     /locus_tag="VVO18_000012"
     CDS             complement(8592..8915)
                     /locus_tag="VVO18_000012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000422771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MazG-like protein"
                     /protein_id="HEU5585243.1"
                     /translation="MELQELVERSWAIRQAYHELEVKHHDSKWTVEEDPLALSNDIGN
                     FQRLVMTKQGRYYDETPYTLEQKLSENIWWLLELSQRLDIDILTEMENFLSDKEKQLN
                     VRTWK"
     gene            complement(9346..9546)
                     /locus_tag="VVO18_000013"
     CDS             complement(9346..9546)
                     /locus_tag="VVO18_000013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001826938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585244.1"
                     /translation="MRRFYSHLPYYLVILFFYWPLYELFLLVVSDPLTLKELYINNLL
                     FFTPLVILIVSLLYSYRFRFSL"
     gene            9784..10413
                     /locus_tag="VVO18_000014"
     CDS             9784..10413
                     /locus_tag="VVO18_000014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398308.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="HEU5585245.1"
                     /translation="MKLAVIAANGQAGKAIVEEVVKRGHEVTAIVRSENKSQSESIIK
                     KDLFELTKDDLTGFDAVISAFGAYTPDTLPLHSKSIELFNQLLAGTQTRFLVVGGAGS
                     LYIDETKTTRLLDTSDFPEEFKSLAKAQADELDLLRTKNNLNWTFVSPAVDFIPDGEK
                     TGNYILAGEIFTTNEKGISQISYADYAIGLVDELEKGHHIKERISLLEK"
     gene            10554..10823
                     /gene="rpsO"
                     /locus_tag="VVO18_000015"
     CDS             10554..10823
                     /gene="rpsO"
                     /locus_tag="VVO18_000015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S15"
                     /protein_id="HEU5585246.1"
                     /translation="MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIK
                     QHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR"
     gene            11638..12252
                     /locus_tag="VVO18_000016"
     CDS             11638..12252
                     /locus_tag="VVO18_000016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000531723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CadD family cadmium resistance transporter"
                     /protein_id="HEU5585247.1"
                     /translation="MGQTIISAIGVYISTSIDYLIILIILFAQLSQNKQKWHIYAGQY
                     LGTGLLVGASLVAAYVVNFVPEEWMVGLLGLIPIYLGIRFAIVGEDAEEEEEEIIERL
                     EQSKANQLFWTVTLLTIASGGDNLGIYIPYFASLDWSQTLVALLVFVIGIIIFCEISR
                     VLSSIPLIFETIEKYERIIVPLVFILLGLYIMYENGTIETFLIV"
     gene            complement(12544..13293)
                     /locus_tag="VVO18_000017"
     CDS             complement(12544..13293)
                     /locus_tag="VVO18_000017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase"
                     /protein_id="HEU5585248.1"
                     /translation="MFYTYLRGLVVLLLWSINGNAHYHNTDKIPNQDENYILVAPHRT
                     WWDPVYMAFATKPKQFIFMAKKELFTNRIFGWWIRMCGAFPIDRENPSASAIKYPINV
                     LKKSDRSLIMFPSGSRHSNDVKGGAALIAKMAKVRIMPVTYTGPMTLKGLISRERVDM
                     NFGNPIDISDIKKMNDEGIETVANRIQTEFQRLDEETKQWHNDKKPNPLWWFIRIPAL
                     ILAIILAILTIIFSFIASFIWNPDKKREELA"
     gene            13426..15762
                     /locus_tag="VVO18_000018"
     CDS             13426..15762
                     /locus_tag="VVO18_000018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IC family P-type ATPase"
                     /protein_id="HEU5585249.1"
                     /translation="MDKNKIMGLTQREVKERQAEGLVNDFTASASTSTWQIVKRNVFT
                     LFNALNFAIALALAFVQAWSNLVFFAVICFNAFSGIVTELRAKHMVDKLNLMTKEKVK
                     TIRDGQEVALNPEELVLGDVIRLSAGEQIPSDALVLEGFAEVNEAMLTGESDLVQKEV
                     DGLLLSGSFLASGSVLSQVHHVGADNYAAKLMLEAKTVKPINSRIMKSLDKLAGFTGK
                     IIIPFGLALLLEALLLKGLPLKSSVVNSSTALLGMLPKGIALLTITSLLTAVIKLGLK
                     KVLVQEMYSVETLARVDMLCLDKTGTITQGKMQVEAVLPLMETYGEEAIASILTSYMA
                     HSEDKNPTAQAIRQRFVGDVAYPMISNLPFSSDRKWGAMELEGLGTVFLGAPEMLLDS
                     EVPEAREALERGSRVLVLALSQEKLDHHKPQKPSDIQALALLEILDSIREGAAETLDY
                     LRSQEVGLKIISGDNPVTVSSIAQKAGFADYHNYVDCSKITDEELMAMAEETAIFGRV
                     SPHQKKLIIQTLKKAGHTTAMTGDGVNDILALREADCSIVMAEGDPATRQIANLVLLN
                     SDFNDVPEILFEGRRVVNNIAHIAPIFLIKTIYSFLLAVICIASALLGRSEWILIFPF
                     IPIQITMIDQFVEGFPPFVLTFERNIKPVEQNFLRKSMLRALPSALMVVFSVLFVKIF
                     GSSQGWSELEISTLLYYLLGSIGFLSVFRACMPFTLWRVLLIVWSVGGFLATALFPRI
                     QKLLEISTLTGQTLPVYGVMMLVFTVIFILTSRYQARK"
     gene            15864..16541
                     /locus_tag="VVO18_000019"
     CDS             15864..16541
                     /locus_tag="VVO18_000019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000624068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenine-N(1))-methyltransferase"
                     /protein_id="HEU5585250.1"
                     /translation="MISKRLELVASFVSQGAILLDVGSDHAYLPIELVERGQIKSAIA
                     GEVVEGPYQSAVKNVEAHGLKEKIQVRLANGLAAFEEADQVSVITIAGMGGRLIARIL
                     EEGLGKLANVERLILQPNNREDDLRIWLQDHGFQIVAESILEEAGKFYEFLVVEVGEM
                     ELSARDTRFGPFLSREISPVFVQKWQKEAEKLEFALGQIPEKNLEERQVLVDKIQAIK
                     EVLHASK"
     gene            16528..17325
                     /locus_tag="VVO18_000020"
     CDS             16528..17325
                     /locus_tag="VVO18_000020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000881127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Nif3-like dinuclear metal center hexameric
                     protein"
                     /protein_id="HEU5585251.1"
                     /translation="MLASEVIKRYEAFCPQEFSMEGDSRGLQIGTLDKGIQRVMVALD
                     IREETVTEAIEKGVDLIIVKHAPIFRPIKDLVASRPQNQIYIDLIKHDIAVYVSHTNI
                     DIVENGLNDWFCQMLGIEETTYLQETGPERGIGRIGNVQSQTFWELTQQVKQVFGLDS
                     LRMVHYQENDLQKPISRVAICGGSGQSFYKDALAKGAEVYITGDIYYHTAQDMLSDGL
                     LALDPGHYIEVLFVEKIAELLTQWKEKKGWELEILPSQASTNPFRHI"
     gene            17342..18445
                     /locus_tag="VVO18_000021"
     CDS             17342..18445
                     /locus_tag="VVO18_000021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-binding oxidoreductase"
                     /protein_id="HEU5585252.1"
                     /translation="MKKVAIIGAGIVGATAAYYLSRESDLEVTVFDHEQGQATKAAAG
                     IISPWFSKRRNKAWYKMARLGADFYVDLLADLEKSGQEIDFYQRSGVFLLKKDESNLE
                     ELYQLALQRREESPLIGQLAILNQASANELFPGLQGFDRLLYASGGARVDGQLLVTRL
                     LEVSHVKLVKEKVTLTPLASGYQIGEEEFEQVILATGAWLGDMLEPLGYEVDVRPQKG
                     QLRDYQLAQDMEDYPVVMPEGEWDLIPFAGGKLSLGATHENDMGFDLTVDETLLQQME
                     EATLTHYLILAEATSKSERVGIRAYTSDFSPFFGQVPDLTGVYAASGLGSSGLTTGPI
                     IGYHLAQLIQDKELTLDPENYPIENYVKRVKSE"
     gene            18746..19765
                     /gene="galE"
                     /locus_tag="VVO18_000022"
     CDS             18746..19765
                     /gene="galE"
                     /locus_tag="VVO18_000022"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEU5585253.1"
                     /translation="MQEKILVTGGAGFIGTHTVIELIQAGHQVVVVDNLVNSNRKSLE
                     VVERITGVEIPFYEADIRDTVTLRDIFKQEEPTGVIHFAGLKAVGESTRIPLAYYDNN
                     IAGTVSLLKAMEENNCKNIIFSSSATVYGDPHTVPILEDFPLSVTNPYGRTKLMLEEI
                     LTDIYKADSEWNVVLLRYFNPIGAHESGDLGENPNGIPNNLLPYVTQVAVGKLEQVQV
                     FGDDYDTEDGTGVRDYIHVVDLAKGHVAALKKIQKGSGLNVYNLGTGKGYSVLEIIQN
                     MEKAVGRPIPYRIVERRSGDIAACYSDPAKAKAELGWEAELDITQMCEDAWRWQSKHP
                     NGFED"
     gene            19767..20720
                     /locus_tag="VVO18_000023"
     CDS             19767..20720
                     /locus_tag="VVO18_000023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5585254.1"
                     /translation="MMISIIVPCLNEEEVLPLFYQALEALLPDLETEIEYVFVDDGSS
                     DGTLELLKAYREQNPAVHYISFSRNFGKEAALYAGLQYATGDLVVVMDADLQDPPSML
                     FEMKNVLDKNVDLDCVGTRRTSREGEPFFRSFCAVLFYRLMQKISPVALPSGVRDFRM
                     MRRSVVDAILSLTESNRFSKGLFAWVGFKTHYLDYPNVERQAGKTSWSFRQLFFYSIE
                     GIVNFSDFPLTIAFVAGLLSCFLSLLMTFFVVVRTLILGNPTSGWTSLMAVILFLGGI
                     QLLTIGILGKYISKIYLETKKRPLYLIKEKSDLPDFTEKIK"
     gene            complement(20782..20988)
                     /locus_tag="VVO18_000024"
     CDS             complement(20782..20988)
                     /locus_tag="VVO18_000024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferredoxin"
                     /protein_id="HEU5585255.1"
                     /translation="MKITLIPERCIACGLCQTYSDLFDYHDNGIVRFYDDPDQLEKEI
                     SPSQDVLEAVKNCPTRALIGNQEA"
     gene            21040..21516
                     /locus_tag="VVO18_000025"
     CDS             21040..21516
                     /locus_tag="VVO18_000025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399345.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM domain-containing protein"
                     /protein_id="HEU5585256.1"
                     /translation="MAKEPWQEDIYDQEESRAGRRHRNHGGADRMANRILTILASIFF
                     VIVVVMVIVLIYLSSGGSNRTAALKDFHDSDASVVQISSSSSSQPEQSSEPESTSSSS
                     EEAANPEGTIKVLAGEGEAAIAARAGISIAQLEALNPGHMATGSWFANPGDVIKIK"
     gene            21525..22196
                     /locus_tag="VVO18_000026"
     CDS             21525..22196
                     /locus_tag="VVO18_000026"
                     /EC_number="2.7.4.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="(d)CMP kinase"
                     /protein_id="HEU5585257.1"
                     /translation="MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYM
                     ALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAI
                     AAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKE
                     NIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAE
                     AEKRM"
     gene            22326..22664
                     /locus_tag="VVO18_000027"
     CDS             22326..22664
                     /locus_tag="VVO18_000027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002920966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkylphosphonate utilization protein"
                     /protein_id="HEU5585258.1"
                     /translation="MNNLPNCPKCNSEYVYEDGALLVCPECAHEWNPAEVAEVEEGLV
                     AIDANGNKLADGDTVTLIKDLKVKGAPKDLKQGTRVKNIRIVEGDHNIDCKIDGFGAM
                     KLKSEFVRKI"
     gene            22667..23296
                     /locus_tag="VVO18_000028"
     CDS             22667..23296
                     /locus_tag="VVO18_000028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000033944.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Pr6Pr family membrane protein"
                     /protein_id="HEU5585259.1"
                     /translation="MSKHYKLVFYSRIFLFLAAFTGVYLEITKHGGFGMLLYYTVLSN
                     LLVTIFTLYLLKVMSRVGENWQRPSLLRLKGGVTMSIMITCVIYHFLLAPIATNFYTL
                     ENFLCHYIVPIWFLADTLFFDKQGQYKIWDPAVWTILPFLYMMFALFNGLVLKLNIPN
                     AKDNPFPYFFLNVNKGWNVVFKWCLIIFVAYMVAGFIFYFIKQIKRKSS"
     gene            23536..24687
                     /locus_tag="VVO18_000029"
     CDS             23536..24687
                     /locus_tag="VVO18_000029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU5585260.1"
                     /translation="MKQFLERASILALSLVLITSFSISSALPAMFDYYQGYSKEQIEL
                     LVSLPSFGIMMMLLLNGFLEKIFPERLQISLGLLILSLSGTAPFWYQAYPFVFGTRLL
                     FGLGLGMINAKAISIISERYQGKRRIQMLGLRASAEVVGASLITLAVGQLLAFGWTAI
                     FLAYSAGFLVLPLYLLFVPYGKSKKEVKKRAKEASRLTREMKGLIFTLAIEAAVVVCT
                     NTAITIRIPSLMVERGLGDAQLSSFVLSIMQLIGIVAGVSFSFLISIFKEKLLLWSGI
                     TFGLGQIVIALSSSLWVVVAGSVLAGFAYSVVLTTVFQLVSERIPAKLLNQATSFAVL
                     GCSFGAFTTPFVLGAIGLLTHNGMLVFSILGGWLIVISIFVMYLLQKRA"
     gene            25005..25754
                     /gene="truA"
                     /locus_tag="VVO18_000030"
     CDS             25005..25754
                     /gene="truA"
                     /locus_tag="VVO18_000030"
                     /EC_number="5.4.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(38-40) synthase TruA"
                     /protein_id="HEU5585261.1"
                     /translation="MTRYKATISYDGYAFAGFQRQPHARSVQEEIEKTLTRLNKGQAI
                     TVHGAGRTDSGVHALGQVIHFDLPYQMDEEKLRFALDTQSPEDIDVISIELVADDFHC
                     RYAKHSKTYEFILDRGRPKNPMRRHYATHFPYPLDVERMQIAIKKLEGTHDFTGFTAS
                     GTSVEDKVRTITEASLIVDETGQFLTFTFSGNGFLYKQIRNMVGTLLKIGNNRMPVEQ
                     IDLILEKKDRQLAGPTAAPNGLYLKEIRYEE"
     gene            25744..26517
                     /locus_tag="VVO18_000031"
     CDS             25744..26517
                     /locus_tag="VVO18_000031"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEU5585262.1"
                     /translation="MKNNRILALSGNDIFSGGGLSADLATYTLNGLHGFVAVTCLTAL
                     TEKGFEVFPTDDTIFQHELDSLRDVEFGGIKIGLLPTVSVAEKALDFIKQRPGVPVVL
                     DPVLVCKETHDVAVSELCQELIRFFPYVSVITPNLSEAELLSGQEIKTLEDMKTAAQK
                     LHDLGAPAVIIKGGNRLSQDKAVDVFYDGQTFTILENPVIQGQNAGAGCTFASSIASH
                     LIKGDKLLPAVESSKAFVYRAIAQADQYGVRQYEANKNN"
     gene            26495..26956
                     /locus_tag="VVO18_000032"
     CDS             26495..26956
                     /locus_tag="VVO18_000032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU5585263.1"
                     /translation="MKQTKTTKIALVSLLTALSVVLGYFLKIPTPTGILTLLDAGVFF
                     AAFYFGSREGAVVGGLASFLIDLLSGYPQWMFFSLVNHGLQGFFAGFKGKSQWLGLIL
                     ATIAMVGGYALGSTLMNGWAAALPEILPNFMQNMVGMIVGFILSQSIKKIK"
     gene            27184..28455
                     /locus_tag="VVO18_000033"
     CDS             27184..28455
                     /locus_tag="VVO18_000033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU5585264.1"
                     /translation="MKLSYDDKVQIYELRKQGYSLEKLSNKFGINNSNLRYMIKLVDR
                     YGIEFVKKGKNRYYSPDLKQEMINKVLHEGWTKDKVSLEYGLPSRTILLNWLAQYRKN
                     GYTIVEKTRGRAPESGECHPKKVKRTPIEGGKRERRKTEIVQELMTEFSLDLLLKAIK
                     LARWTYYYYLKQLDKTDKDQELKAEIQSIFIEHKGNYGYRRIYLELRNRAYLVNHKRV
                     QGLMKVLNLQAKMRQKRKYSSHKGDVGKKAENLIQGQFEGSKTMEKCYTDVTEFAIPA
                     STQKLYLSPVLDGFNSEIIAYNLSTSPNLEQVQTMLEQAFTEKHYENTILHSDQGWQY
                     QHDSYHRFLESKGIQASMSRKGNSQDNGMMESFFGILKSEMFYSYEKTFKSLNQLEQA
                     IVDYIDYYNNKRIKVKLKGLSPVQYRTKSFG"
     gene            complement(28582..28785)
                     /locus_tag="VVO18_000034"
     CDS             complement(28582..28785)
                     /locus_tag="VVO18_000034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585265.1"
                     /translation="MIKLYSPYAFLSKYLGAILLSFFCYYAKEIGCSNLTLSVWNDNE
                     GALRFYQRQGMKPQETTMEMRID"
     gene            complement(28778..29860)
                     /locus_tag="VVO18_000035"
     CDS             complement(28778..29860)
                     /locus_tag="VVO18_000035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEU5585266.1"
                     /translation="MSKLQQILTYLESEKLDVAVVSDPVTINYLTGFYSDPHERQMFL
                     FVLADQEPLLFVPALEVERASSTVSFPVVGYVDSENPWQKIKHALPQLDFKRVAVEFD
                     NLILTKYHGLKTVFETAEFDNLTPRIQRMRLIKSADEVQKMMVAGLYADKAVHVGFDN
                     ISLDKTETDIIAQIDFAMKREGYEMSFDTMVLTGDNAANPHGIPAANKVENDALLLFD
                     LGVLVNGYASDMTRTVAVGKPDQFKKDIYNLTLEAQQAALDFIKPGVTAHEVDRAARE
                     VIEKAGYGEYFNHRLGHGIGMDVHEFPSIMEGNDMVIEEGMCFSVEPGIYIPGKVGVR
                     IEDCGVVTKDGFDLFTSTSKDLLYFD"
     gene            complement(29986..30768)
                     /locus_tag="VVO18_000036"
     CDS             complement(29986..30768)
                     /locus_tag="VVO18_000036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glutamine amidotransferase"
                     /protein_id="HEU5585267.1"
                     /translation="MVYTSLSSKDGNYPYQLNIAHLYGNLMNTYGDNGNILMLKYVAE
                     KLGAHVIVDIVSLHDDFDANHYDIAFFGGGQDFEQSIIADDLPAKKESIDNYIQNDGV
                     VLAICGGFQLLGQYYVEASGKRIEGLGVMGHYTLNQTNNRFIGDIKIHNEDFDETYYG
                     FENHQGRTFLSDDQKPLGQVVYGNGNNEEKVGEGVHYKNVFGSYFHGPILSRNANLAY
                     RLVTTALKKKYGQDIQLPAYEDILSQEIAEEYSDVKSKADFS"
     gene            complement(30768..32111)
                     /locus_tag="VVO18_000037"
     CDS             complement(30768..32111)
                     /locus_tag="VVO18_000037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mur ligase family protein"
                     /protein_id="HEU5585268.1"
                     /translation="MNLKTTLGLLAGRSSHFVLSRLGRGSTLPGKVALQFDKDILQNL
                     AKNYEIVVVTGTNGKTLTTALTVGILKEVYGQVLTNPSGANMITGIATTFLTAKSSKT
                     GKNIAVLEIDEASLSRICDYIQPSLFVITNIFRDQMDRFGEIYTTYNMILDAIRKVPT
                     ATVLLNGDSPLFYKPTIPNPIEYFGFDLEKGPAQLAHYNTEGILCPDCQGILKYEHNT
                     YANLGAYICEGCGCKRPDLDYRLTKLVELTNNRSRFVIDGQEYGIQIGGLYNIYNALA
                     AVAIARFLGADLQLIKQGFDKSRAVFGRQETFHIGDKECTLVLIKNPVGATQAIEMIK
                     LAPYPFSLSVLLNANYADGIDTSWIWDADFEQITDMDIPEINAGGVRHSEIARRLRVT
                     GYPAEKITETSNLEQVLKTIENQDCKHAYILATYTAMLEFRELLASRQIVRKEMN"
     gene            complement(32223..33539)
                     /locus_tag="VVO18_000038"
     CDS             complement(32223..33539)
                     /locus_tag="VVO18_000038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000958936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-containing oxidoreductase"
                     /protein_id="HEU5585269.1"
                     /translation="MLTYDLIVIGFGKAGKTLAGKLASAGKKVALVERSKAMYGGTCI
                     NIGCIPTKTLLVAAEKDLSFEEVIATKNTITGRLNGKNYTTVAGTGVDIFDAEAHFLS
                     NKVIEIQAGDEKQELTAETIVINTGAVSNVLPIPGLATSKNVFDSTGIQSLDKLPEKL
                     GVLGGGNIGLEFAGLYNKLGSKVTVLDALDTFLPRAEPSIAALAKQYMEEDGIELLQN
                     IHTTEIKNDGDQVLVVTEDETYRFDALLYATGRKPNVEPLQLENTDIELTERGAIKVD
                     KHCQTNVPGVFAVGDVNGGLQFTYISLDDFRVVYSYLAGDGSYTLEDRLNVPNTMFIT
                     PALSQVGLTESQAADLKLPYAVKEIPVAAMPRGHVNGDLRGAFKAVVNTETKEILGAS
                     IFSEGSQEIINIITVAMDNKIPYTYFTKQIFTHPTLAENLNDLFAI"
     gene            33733..34959
                     /locus_tag="VVO18_000039"
     CDS             33733..34959
                     /locus_tag="VVO18_000039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OFA family MFS transporter"
                     /protein_id="HEU5585270.1"
                     /translation="MKSNRYIIAFAGVILHLMLGSTYAWSVYRNPIIEKTGWDQASVA
                     FAFSLAIFCLGLSAAFMGRLVEKFGPRVMGSLSAFLYAGGNILTGFAIDRQELWLLYL
                     AYGILGGLGLGAGYITPVSTIIKWFPDKRGLATGLAIMGFGFASLLTSPIAQHLIAGV
                     GLVETFYILGASYFIIMLLASQFIKRPNEQELAILSASGKEKTDSLTQGMTANQALKS
                     NRFYILWIIFFINIACGLGLISAASPMAQEMAGLSTSHAAVMVGVLGIFNGFGRLLWA
                     SLSDYIGRPLTFSILLLVNLFFSLSLWLFTDSVLFVVAMSILMTCYGAGFSLIPAYLS
                     DIFGTKELAALHGYILTAWAMAGLAGPILLAETYKMAHSYTQTLFVFLILYSIALALS
                     YYLGRSIKKESQKPLT"
     gene            35158..36732
                     /locus_tag="VVO18_000040"
     CDS             35158..36732
                     /locus_tag="VVO18_000040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU5585271.1"
                     /translation="MKFNELNLSADLLAEIEKAGFVEASPIQEQTIPLALEGKDVIGQ
                     AQTGTGKTAAFGLPTLEKIRTEEATIQALVIAPTRELAVQSQEELFRFGRSKGVKVRS
                     VYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLQDIESLILDEADEMLNMGF
                     LEDIEAIISRVPENRQTLLFSATMPDAIKRIGVQFMKAPEHVKIAAKELTTELVDQYY
                     IRVKEQEKFDTMTRLMDVAQPELAIVFGRTKRRVDELTRGLKIRGFRAEGIHGDLDQN
                     KRLRVLRDFKNGNLDVLVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAG
                     KSGQSITFVAPNEMGYLQIIENLTKKRMKGLKPASVEESFQSKKQVALKKIERDFADE
                     TIRANFEKFGKDARKLAAEFTPEELAMYILSLTVQDPDSLPEVEIAREKPLPFKPSGN
                     GFGGKAKGGRGGRRGDDRRERDRRGNGRRDEFKKGSRGNDRFDKEKRYRKDNKKPRNT
                     LSEKQTGFVIRNKGDK"
     gene            36997..37785
                     /gene="codY"
                     /locus_tag="VVO18_000041"
     CDS             36997..37785
                     /gene="codY"
                     /locus_tag="VVO18_000041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP-sensing pleiotropic transcriptional
                     regulator CodY"
                     /protein_id="HEU5585272.1"
                     /translation="MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNAC
                     IINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIF
                     PVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLN
                     FQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITR
                     SVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY"
     gene            37785..38360
                     /locus_tag="VVO18_000042"
     CDS             37785..38360
                     /locus_tag="VVO18_000042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEU5585273.1"
                     /translation="MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFER
                     GDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMD
                     KRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVAS
                     IWPENHQFALGHFKNTLGAKLVDENLNELSE"
     gene            38442..38527
                     /locus_tag="VVO18_000043"
     tRNA            38442..38527
                     /locus_tag="VVO18_000043"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:38476..38478,aa:Leu,seq:aag)
     gene            38810..39940
                     /gene="ugpC"
                     /locus_tag="VVO18_000044"
     CDS             38810..39940
                     /gene="ugpC"
                     /locus_tag="VVO18_000044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sn-glycerol-3-phosphate ABC transporter
                     ATP-binding protein UgpC"
                     /protein_id="HEU5585274.1"
                     /translation="MVELNLKNIYKKYPNSEHYSVEDFNLNIKDKEFIVFVGPSGCGK
                     STTLRMIAGLEDITEGTASIDGVVVNDVAPKDRDIAMVFQNYALYPHMTVYDNMAFGL
                     KLRKYSKEDINKRVQEAAEILGLKEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMD
                     EPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATKNPAGT
                     GTIGRVEQIGTPQEVYKNPVNKFVAGFIGSPAMNFINVKLVGSEIVSDGFRLKVPEGA
                     LKVLREKGYEGKELIFGIRPEDVNAEPAFLETFPDCVVKATISVSELLGSESHLYCQV
                     GKDEFVAKVDARDYLQTGATVELGFDLNKAHFFDVETEKTIY"
     gene            complement(40063..40233)
                     /locus_tag="VVO18_000045"
     CDS             complement(40063..40233)
                     /locus_tag="VVO18_000045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585275.1"
                     /translation="MEIKEQTRKLAVSYSKYSFEVADKTDEVSNHTYGKATLTWFEEI
                     FEEYKEHHNIDV"
     gene            40441..41199
                     /locus_tag="VVO18_000046"
     CDS             40441..41199
                     /locus_tag="VVO18_000046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001848902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEU5585276.1"
                     /translation="MSEAGHKFLAKLGKKRLRPGGKRATDWLIAEGGFSKEKRILEVA
                     CNRGTTAIELAQRFGCKITAIDMDAQALEVAKKSAGTAGVAHLISFERANAMKLPYQD
                     ASFDIVINEAMLTMQADQAKKKCVMEYLRVLKPGGLLLTHDVLLKEAKESIRQELSQA
                     IHVNVGPLTQDGWEQVMIESGYCDVKALTGEMTLMKLSGMIYDEGLLGTLKICVNACK
                     KENRKQFLTMYKMFAKNKQKLGFIAMASYKSSKR"
     gene            41286..41798
                     /locus_tag="VVO18_000047"
     CDS             41286..41798
                     /locus_tag="VVO18_000047"
                     /EC_number="2.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="HEU5585277.1"
                     /translation="MNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYA
                     TDKKVDMIVGPEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLT
                     MHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIG
                     DYDYKVLMHY"
     gene            41980..42924
                     /locus_tag="VVO18_000048"
     CDS             41980..42924
                     /locus_tag="VVO18_000048"
                     /EC_number="2.3.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine O-succinyltransferase"
                     /protein_id="HEU5585278.1"
                     /translation="MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLM
                     PQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDG
                     MIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQM
                     DSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVG
                     VSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLC
                     WSSSAALFFSNWINHAVYQETPFDWRKIEDDASAYGYL"
     gene            42933..43610
                     /locus_tag="VVO18_000049"
     CDS             42933..43610
                     /locus_tag="VVO18_000049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaD domain-containing protein"
                     /protein_id="HEU5585279.1"
                     /translation="MTYLDAFKSGILVLPSALLLHFKELFPSSDDFLVWQFFYLQNTT
                     GLEEMSPSQIAERIGKEISDVNQSISNLTERGLLQYRTIELNGEIELLFDASLALERL
                     DDLFGAVHSSSDQLTPQNQLKDLVETFQQELGRLLTPFEIEDLTKTLKEDGTSADLIK
                     EALREAVLNGKPNWKYIQAILRNWRHEGIKSVAQIEAKRAEREASNPQLTQVSADFRN
                     AMDLWKD"
     gene            43709..44467
                     /locus_tag="VVO18_000050"
     CDS             43709..44467
                     /locus_tag="VVO18_000050"
                     /EC_number="5.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000087908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="triose-phosphate isomerase"
                     /protein_id="HEU5585280.1"
                     /translation="MSRKPFIAGNWKMNKNPEEAKAFVEAVASKLPSSDLVEAGIAAP
                     ALDLTTVLAVAKGSNLKVAAQNCYFENAGAFTGETSPQVLKEIGTDYVVIGHSERRDY
                     FHETDEDINKKAKAIFANGMLPIICCGESLETYEAGKAAEFVGAQVSAALAGLTAEQV
                     AASVIAYEPIWAIGTGKSASQDDAQKMCKVVRDVVAADFGQEVADKVRVQYGGSVKPE
                     NVASYMACPDVDGALVGGASLEAESFLALLDFVK"
     gene            44505..46010
                     /gene="lytC"
                     /locus_tag="VVO18_000051"
     CDS             44505..46010
                     /gene="lytC"
                     /locus_tag="VVO18_000051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_078138769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase LytC"
                     /protein_id="HEU5585281.1"
                     /translation="MSVTFFIGEERLKIKIGLASICLLGLATSHVAANETEVAKTSQD
                     TTTASSSSEQNQSSNKTQTSAEVQTNAAAHWDGDYYVKDDGSKAQSEWIFDNYYKAWF
                     YINSDGRYSQNEWHGNYYLKSGGYMAQNEWIYDSNYKSWFYLKSDGVYAHQEWQLIGN
                     KWYYFKKWGYMAKSQWQGSYFLNGQGAMMQNEWLYDPAYSAYFYLKSDGTYANQEWQK
                     VGGKWYYFKKWGYMARNEWQGNYYLTGSGAMATDEVIMDGARYIFAASGELKEKKDLN
                     VGWVHRDGKRYFFNNREEQVGTEHAKKIIDISEHNGRINDWKKVIDENEVDGVIVRLG
                     YSGKEDKELAHNIKELNRLGIPYGVYLYTYAENETDAENDAKQTIELIKKYNMNLSYP
                     IYYDVENWEYVNKSKRAPSDTDTWVKIINKYMDTMKQAGYQNVYVYSYRSLLQTRLKH
                     PDILKHVNWVAAYTNALEWENPYYSGEKGWQYTSSEYMKGIQGRVDVSVWY"
     gene            46507..47025
                     /locus_tag="VVO18_000052"
     CDS             46507..47025
                     /locus_tag="VVO18_000052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="HEU5585282.1"
                     /translation="MVELKKEAVKDVTSLTKAAPVALAKTKEVLNQAVADLYVAHVAL
                     HQVHWYMHGRGFLVWHPKMDEYMEALDGHLDEISERLITLGGSPFSTLTEFLQNSEIE
                     EEAGEYRNVEESLERVLAIYRYLITLFQKALDVTDEEGDDVTNDIFVGAKAELEKTVW
                     VLAAELGQAPGL"
     gene            47155..47661
                     /locus_tag="VVO18_000053"
     CDS             47155..47661
                     /locus_tag="VVO18_000053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrofolate reductase"
                     /protein_id="HEU5585283.1"
                     /translation="MTKKIVAIWAQDEDGVIGKDNRLPWHLPAELQHFKETTLNHAIL
                     MGRVTFDGMGRRLLPKRETLILTRNSEEKLDGVATFHDVQSVLDWYHAQDKNLYILGG
                     KQIFQAFEPYLDEVIVTHIHARVEGDTYFPEEFDLSLFETVSSKSYTKDEKNPYDFTI
                     QYRKRKEV"
     gene            47661..47831
                     /locus_tag="VVO18_000054"
     CDS             47661..47831
                     /locus_tag="VVO18_000054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000442275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585284.1"
                     /translation="MERSLFGLFTAFLCFICLLAGAQAFRKKRYGLSILLWLNAFTNL
                     VNSIHAFYMTLF"
     gene            47863..49095
                     /gene="clpX"
                     /locus_tag="VVO18_000055"
     CDS             47863..49095
                     /gene="clpX"
                     /locus_tag="VVO18_000055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002874765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /protein_id="HEU5585285.1"
                     /translation="MSTNRKNDMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQE
                     IIREELVEEVLADLSEVPKPIELLHILNHYVIGQDRAKRALAVAVYNHYKRINFHDTR
                     EESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
                     ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGT
                     VASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAI
                     DENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALVKQYQ
                     TLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLV
                     RITKEAVDGTDKPILETA"
     gene            49104..49691
                     /locus_tag="VVO18_000056"
     CDS             49104..49691
                     /locus_tag="VVO18_000056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002915299.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihA family ribosome biogenesis GTP-binding
                     protein"
                     /protein_id="HEU5585286.1"
                     /translation="MELNTHNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINT
                     MLNRKNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGRMIEEYL
                     TTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESA
                     IKKKLNFDPSDDFILFSSVSKAGMDEAWDAILEKL"
     gene            49702..50082
                     /locus_tag="VVO18_000057"
     CDS             49702..50082
                     /locus_tag="VVO18_000057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RidA family protein"
                     /protein_id="HEU5585287.1"
                     /translation="MAKTIHTDKAPKAIGPYVQGKIVGNLLFASGQVPLSPETGEIVG
                     ENIQEQTEQVLKNIGAILAEAGTDFDHVVKTTCFLSDMNDFVPFNEVYQTAFKEEFPA
                     RSAVEVARLPRDVKVEIEVIAEIG"
     gene            50134..51024
                     /gene="rapZ"
                     /locus_tag="VVO18_000058"
     CDS             50134..51024
                     /gene="rapZ"
                     /locus_tag="VVO18_000058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNase adapter RapZ"
                     /protein_id="HEU5585288.1"
                     /translation="MTKKQLHLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALLPK
                     FLQLVEIKEDNPKLALVVDMRSRSFFSEIQAVLDELENQDGLDFKILFLDAADKELVA
                     RYKETRRSHPLAADGRILDGIKLERELLAPLKNMSQNVVDTTELTPRELRKTLAEQFS
                     DQEQAQSFRIEVMSFGFKYGIPIDADLVFDVRFLPNPYYLPELRNQTGVDEPVYDYVM
                     NHPESEDFYQHLLALIEPILPSYQKEGKSVLTIAMGCTGGQHRSVAFAKRLVQDLSKN
                     WSVNEGHRDKDRRKETVNRS"
     gene            51021..51998
                     /locus_tag="VVO18_000059"
     CDS             51021..51998
                     /locus_tag="VVO18_000059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399181.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YvcK family protein"
                     /protein_id="HEU5585289.1"
                     /translation="MRKPKITVIGGGTGIPVILKSLREKDVEIAAIVTVADDGGSSGE
                     LRKNMQQLTPPGDLRNVLVAMSDMPKFYEKVFQYRFSEDAGAFAGHPLGNLIIAGLSE
                     MQGSTYNAMQLLSKFFHTTGKIYPSSDHPLTLHAVFQDGTEVAGESHIVDHRGIIDNV
                     YVTNALNDDTPLASRRVVQTILESDMIVLGPGSLFTSILPNIVIKEIGRALLETKAEI
                     AYVCNIMTQRGETEHFTDSDHVEVLHRHLGRPFIDTVLVNIEKVPQEYMNSNRFDEYL
                     VQVEHDFVGLCKQVSRVISSNFLRLENGGAFHDGDLIVDELMRIIQVKK"
     gene            51995..52906
                     /gene="whiA"
                     /locus_tag="VVO18_000060"
     CDS             51995..52906
                     /gene="whiA"
                     /locus_tag="VVO18_000060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein WhiA"
                     /protein_id="HEU5585290.1"
                     /translation="MSFTVAVKEEILGQHHLSRHELSAIIKMSGSIGLSTSGLTLSVV
                     TENAKLARHLYESFLHFYEIKSEIRHHQRSNLRKNRVYTVFTDEKVQDLLSDLHLADS
                     FFGLETGIDEAILSDEEAGRAYLCGAFLANGSIRDPESGKYQLEISSVYLDHAQGIAS
                     LLQQFLLDAKVLERKKGAVTYLQRAEDIMDFLIVIGAMQARDDFERVKILRETRNDLN
                     RANNAETANIARTVSASMKTINNISKIKDIMGLENLPVDLQEVAQLRIQHPDYSIQQL
                     ADSLSTPLTKSGVNHRLRKINKIADEL"
     gene            complement(52940..53908)
                     /locus_tag="VVO18_000061"
     CDS             complement(52940..53908)
                     /locus_tag="VVO18_000061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000081018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEU5585291.1"
                     /translation="MSQLYDITIVGGGPVGLFAAFYAHLRQAKVQIIDSLPQLGGQPA
                     ILYPEKEILDVPGFPNLTGEELTNRLIEQLNGFDTPIHLNETVLEIDKQEEEFAITTS
                     KGSHLTKTVIIAMGGGAFKPRPLELEGVEDYENIHYHVSNIQQYAGKKVTILGGGDSA
                     VDWALAFEKIAPTTLVHRRDNFRALEHSVQTLQESSVTIKTPFAPSQLLGNGKTLDKL
                     EITKVKSDETETIDLDHLFVNYGFKSSVGNLKNWGLDLNRHKIIVNSKQESSQAGIYA
                     IGDCCYYDGKIDLIATGLGEAPTAVNNAINYIDPEQKVQPKHSTSL"
     gene            54044..54901
                     /locus_tag="VVO18_000062"
     CDS             54044..54901
                     /locus_tag="VVO18_000062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001867651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00159 family protein"
                     /protein_id="HEU5585292.1"
                     /translation="MNFQQLSNLQYWTSLFASPWTIAINLIDILIVAYILYHFTKAIA
                     GTKIMILVRGVLVFILAQILANMIGLTTISWLINQIITYGVIAAVVIFSPEIRTGLER
                     LGRATDFFSNAPISAEEQMIRAFVKSVEYMSPRKIGALVAIQRVRTLQEYMSTGIPLD
                     AKISAELLINIFIPNTPLHDGAVIIKEERIAVTSAYLPLTKNTGISKEFGTRHRAAIG
                     LSEVSDALTFVVSEETGGISITYNGRFKHNLTLDEFETELREILLPKEEVGLSFKERL
                     LGGWKHEKK"
     gene            54888..55667
                     /locus_tag="VVO18_000063"
     CDS             54888..55667
                     /locus_tag="VVO18_000063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbbR-like domain-containing protein"
                     /protein_id="HEU5585293.1"
                     /translation="MKKNSLYIISSLFFACVLFVYATATNFQNSTSARQVKTETYTNT
                     VTNVPIDIRYNSDKYFISGFASEVSVVLTGANRLSLASEMQESTRKFKVTADLTDAGV
                     GTIEVPLSIEDLPNGLTAVATPQKITVKIGKKAQKDKVKIVPEIDPSQIDSRVQIENV
                     MVSDKEVSITSDQETLDRIDKIIAVLPTSERITGNYSGSVPLQAIDRNGVVLPAVITP
                     FDTIMKVTTKPVAPSSSTSNSSTSSSSETSSSTKATSSKTN"
     gene            55691..57043
                     /locus_tag="VVO18_000064"
     CDS             55691..57043
                     /locus_tag="VVO18_000064"
                     /EC_number="5.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglucosamine mutase"
                     /protein_id="HEU5585294.1"
                     /translation="MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKV
                     FVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMISASH
                     NPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPRPSAEGLGILVDYPEGLRKY
                     EGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGS
                     THPEALQEMVKESGSAIGLAFDGDSDRLIAVDENGDIVDGDKIMYIIGKYLSEKGQLA
                     QNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMD
                     YNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENAMKEKAMEVPAI
                     KAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
                     "
     gene            57117..57491
                     /locus_tag="VVO18_000065"
     CDS             57117..57491
                     /locus_tag="VVO18_000065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1149 family protein"
                     /protein_id="HEU5585295.1"
                     /translation="MNLKREQEFVSQYHFDARNFEWENENGAPETKVDVNFQLLQHDQ
                     ENQVTSLIVILSFMIVFDKFVISGTISQVNHIDGRIVNEPSELNQEEVETLARPCLNM
                     LNRLTYEVTEIALDLPGINLEF"
     gene            57493..58341
                     /locus_tag="VVO18_000066"
     CDS             57493..58341
                     /locus_tag="VVO18_000066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU5585296.1"
                     /translation="MKLAVFTDSSAYLSEETLQREDLFVLDIPVNIDGEEYVEGINLS
                     AEEFYQKMAQASELPKTSQPSIAKLDEILTSLKEQGYTHALGLFLSSGISGFYQNIQY
                     MVDDYEGLTIAFPDTLITSAPLGIMVESVFNWRDQGDDFASIQDKLAIQISRTSAFIM
                     VDDLDHLVKGGRLSNGAAILGNLLSIKPILYFNDQGVIEVYEKVRTEKKATKRLIEII
                     KETTASGQYRVIVIHGNAPEKAEELRQHLLDFGLGSDVSLATFGSVIGTHLGAGSIAL
                     GYIPVI"
     gene            58607..59374
                     /locus_tag="VVO18_000067"
     CDS             58607..59374
                     /locus_tag="VVO18_000067"
                     /EC_number="1.17.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="HEU5585297.1"
                     /translation="MSIRVIIAGFKGKMGQAACQMVLTDPDLDLVAVLDPFESESEWQ
                     GIPVFKDKADLAGFEADVWVDFTTPAVAYENTRFALENGFAPVVGTTGFTSEEIAELK
                     EFSRAQDLGGLIAPNFALGAVLLMQFATQAAKYFPNVEIIELHHDKKKDAPSGTAIKT
                     AELMAEVRESIQQGAADEEELIAGARGADFDGMRIHSVRLPGLVAHQEVIFGNQGEGL
                     TLRHDSYDRISFMTGVNLGIKEVVKRHELVYGLEHLL"
     gene            59386..60570
                     /locus_tag="VVO18_000068"
     CDS             59386..60570
                     /locus_tag="VVO18_000068"
                     /EC_number="2.7.7.72"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001138849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CCA tRNA nucleotidyltransferase"
                     /protein_id="HEU5585298.1"
                     /translation="MPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIA
                     TSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVR
                     SLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMR
                     GFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIES
                     QAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSR
                     QFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQ
                     SLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLRE
                     KK"
     gene            60567..62438
                     /locus_tag="VVO18_000069"
     CDS             60567..62438
                     /locus_tag="VVO18_000069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001279112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU5585299.1"
                     /translation="MSDFIVEKLSKSVGDKTVFRDISFIIHDLDRIGLIGVNGTGKTT
                     LLDVLSGVSGFDGDVSPFSAKNDYQIGYLTQDPDFDDRKTVLDTVLSSELKEIQLIRE
                     YELIMLDYSEDKQARLERVMAEMDSLQAWEIESQVKTVLSKLGIQDLSTPVGELSGGL
                     RRRVQLAQVLLGNHDLLLLDEPTNHLDIAIIEWLTLFLKNSKKTVLFITHDRYFLDAL
                     STRIFELDRAGLTEYQGNYQDYVRLKAEQDERDAALLHKKEQLYKQELAWMRRQPQAR
                     ATKQQARINRFHDLKKEVSGSSAETDLTMNFETSRIGKKVIEFQAVSFAYENKPILQD
                     FNLLVQAKDRIGIVGDNGVGKSTLLNLIAGSLEPTKGQVVIGETVRIAYFSQQIEGLD
                     ESKRVINYLQEVAEEVKTSGGSTTSIAELLEQFLFPRSTHGTLIEKLSGGEKKRLYLL
                     KLLLEKPNVLLLDEPTNDLDIATLTVLENFLQGFAGPVLTVSHDRYFLDKVATKILAF
                     EDGKIRPFFGHYTDYLDEKAFETDMANQVQKVEKEKVVKVREDKKRMTYQEKQEWASI
                     EGDIETLEKRIAAIEEEMQANGSDFGKLATLQKELDEKNEALLEKYERYEYLSEFDS"
     gene            complement(62581..63765)
                     /gene="mntE"
                     /locus_tag="VVO18_000070"
     CDS             complement(62581..63765)
                     /gene="mntE"
                     /locus_tag="VVO18_000070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813920.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDF family manganese efflux transporter MntE"
                     /protein_id="HEU5585300.1"
                     /translation="MKQSISNLKLAERGAIISISTYLILSAAKLAAGHLLHSSSLVAD
                     GFNNVSDIIGNVALLIGIRMARQPADRDHRFGHWKIEDLASLITSIIMFYVGFDVLRD
                     TIQKILSREETVIDPLGATLGIISAAIMFVVYLYNTRLSKKSNSKALKAAAKDNLSDA
                     VTSLGTAIAILASSFNYPIVDKLVAIIITFFILKTAYDIFIESSFSLSDGFDDRLLED
                     YQKAIMEIPKISKVKSQRGRTYGSNIYLDITLEMNPDLSVFESHEIADQVESMLEERF
                     GVFDTDVHIEPAPIPEDEILDNVYKKLLMREQLIDQGNQLEELLTDDFVYIRQDGEQM
                     DKEAYKTKKELNSAIKDIQITSISQKTKLICYELDGIIHTSIWRRHETWQNIFHQETK
                     KE"
     gene            64069..66765
                     /locus_tag="VVO18_000071"
     CDS             64069..66765
                     /locus_tag="VVO18_000071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation-translocating P-type ATPase"
                     /protein_id="HEU5585301.1"
                     /translation="MSKEQKRQAFYTQSPEEVLQAVDATEQGLSSSEAEKRLAEFGHN
                     ELEEGEKRSILVKFIEQFKDLMIIILVAAAILSVVTSGGEDIADAIIILAVVIINAAF
                     GVYQEGKAEEAIEALKSMSSPVARVLRDGHMAEIDSKELVPGDIVALEAGDVVPADLR
                     LIEANSLKIEEAALTGESVPVEKDLSVELATDAGIGDRVNMAFQNSNVTYGRGMGVVV
                     NTGMYTEVGHIAGMLQDADETDTPLKQNLNNLSKVLTYAILVIALVTFVVGVFIQGKN
                     PLGELLTSVALAVAAIPEGLPAIVTIVLSLGTQVLAKRHSIVRKLPAVETLGSTEIIA
                     SDKTGTLTMNKMTVEKVFYDAVLHDSADDIELGLEMPLLRSVVLANDTKIDVEGNLIG
                     DPTETAFIQYALDKGYDVKGFLEKYPRVAELPFDSDRKLMSTVHPLPDGRFLVAVKGA
                     PDQLLKRCLLRDKAGDIAPIDEKVTNLIHTNNSEMAHQALRVLAGAYKIIDSIPENLT
                     SEELENDLIFTGLIGMIDPERPEAAEAVRVAKEAGIRPIMITGDHQDTAEAIAKRLGI
                     IDANDTEGHVLTGAELNELSDEEFEKVVGQYSVYARVSPEHKVRIVKAWQKQGKVVAM
                     TGDGVNDAPALKTADIGIGMGITGTEVSKGASDMILADDNFATIIVAVEEGRKVFSNI
                     QKTIQYLLSANTAEVLTIFLSTLFGWDVLQPVHLLWINLVTDTFPAIALGVEPAEPGV
                     MNHKPRGRKASFFSGGVLSSIIYQGVLQAALVMSVYGLAIAYPVHVGDNHAIHADALT
                     MAFATLGLIQLFHAYNVKSVYQSILTVGPFKSKTFNWSILVSFILLMATIVVEPLEGI
                     FHVTKLDLSQWGIVMAGSFSMIIIVEIVKFIQRKLGFDKNAI"
     gene            66778..67569
                     /gene="yghU"
                     /locus_tag="VVO18_000072"
     CDS             66778..67569
                     /gene="yghU"
                     /locus_tag="VVO18_000072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-dependent disulfide-bond
                     oxidoreductase"
                     /protein_id="HEU5585302.1"
                     /translation="MSAYQLPTVWQDEASNQGAFTGLNRPTAGARFEQNLPKGEQAFQ
                     LYSLGTPNGVKVTILLEELLEAGFKEAAYDLYKIAIMDGDQFGSDFVKLNPNSKIPAL
                     LDQSGTENVRVFESAHILLYLAEKFGAFLPSNPVEKVEVLNWLFWQAGAAPFLGGGFG
                     HFFNYAPEKLEYPINRFTMEVKRQLDLLDKELAQKPYIAGNDYTIADIAIWSWYGQLV
                     QGNLYQGSAKFLDASSYQNLVKWAEKIANRPAVKRGLEVTYTEIK"
     gene            67685..68095
                     /locus_tag="VVO18_000073"
     CDS             67685..68095
                     /locus_tag="VVO18_000073"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEU5585303.1"
                     /translation="MEKKIVKDILFLSQVSQPASQEDLYLARDLQDTLLANRDTCVGL
                     AANMIGVQKRVIIFNLGLVPVVMFNPVLLSFEGSYEAEEGCLSLVGVRSTKRYETIRL
                     AYRDSKWQEQTITLTGFPAQICQHELDHLEGRII"
     gene            68107..69702
                     /locus_tag="VVO18_000074"
     CDS             68107..69702
                     /locus_tag="VVO18_000074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000822862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585304.1"
                     /translation="MKRIVFELIFIATTWYIFLPPLNLTSWEFLFFLCGHLLVVAILF
                     GFGKGINLVKTVHVRHGKAEAALNLEGFKINRLGKILLASIGGILLLAALVSLVTSSM
                     FQAKNYANVVTVTEKDFTEFPKSDTSKVPILDRSTAEKIGDRYLGSLTDKVSQYVAAD
                     TYTQLTIDGKPYRVTPLEYADPIKWFNNQAKGIGEYIKVDMVTGNADLVDLKTPIKYS
                     DSEYFNRDVKRHLRLKYPTKIFKTPSFEVDDEGNPFYVATVYQKQFGLAVPRPASVII
                     LDATNGETKEYSLSDVPEWVDRIYPAEETIEQINYNGKYKDGFLNAMISKKNVTQTTN
                     GYNYLSIGNDIYLYTGVTSANADESNLGFILENMRTGEITKYSLASATEESARESAEG
                     AVQEKSYKATFPILINLNDKPLYIMGLKDNAGLVKEYALVDAVEYQNVIVATTVEEML
                     SKYANKNDLEIDNATTESIKGVVADLKSAVIKGDTVYFFKVDGKIYKVKASVSDDLPY
                     LENGKTFEGQVGKDNYLKTFKLR"
     gene            69768..69932
                     /locus_tag="VVO18_000075"
     CDS             69768..69932
                     /locus_tag="VVO18_000075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000508323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YczI family protein"
                     /protein_id="HEU5585305.1"
                     /translation="MGFYLMVASMLLGLLALKIGFSQFKENKDKFLSILTSLAGLALV
                     LVAVWLGWPK"
     gene            70011..70739
                     /gene="yaaA"
                     /locus_tag="VVO18_000076"
     CDS             70011..70739
                     /gene="yaaA"
                     /locus_tag="VVO18_000076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peroxide stress protein YaaA"
                     /protein_id="HEU5585306.1"
                     /translation="MKILIPTAKEMNTDLPSIETTLLRSESQAVLDALALYSASQLES
                     FYKVSAEKAAEECQNIQALKRQTAQHYPALKLFDGLMYRHIKRDKLTEVEQAYLENHV
                     FITSALYGVVPALSPMAPHRLDFLMKLKVAGKTLKSHWKAAYDEAVKQEEVIFSLLSS
                     EFETVFSKEIRAKMVTFKFMEDRGGQLKIHSTISKKARGAFLTALIENQVQTVGEARR
                     LNFAGFVYREDLSQPQGLVFVKEV"
     gene            complement(70790..72274)
                     /locus_tag="VVO18_000077"
     CDS             complement(70790..72274)
                     /locus_tag="VVO18_000077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003096885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5585307.1"
                     /translation="MRNLLSTKVQRQLRLMETLIQNRNWMKLHELAEKLGCTERILKS
                     DLNELRIAFPSINIQSSVNGIMIDLEVNTSVEDIYQYFLANSQSFQLLEYMFFNEGLP
                     IYRTIENLYFSSANLYRLGRNITKVLSFQFQIELSFTPSEIRGNEIDIRYFFAQYFSE
                     RYYFLDWPFPDLPEEDLTEFADFFYKITNYPMRFSIYRMYKLMIAISIHRVKNGHFID
                     LPNHFYKEYYPLLKSIPNFQETLAYFSKHFGLEMTPDTIAQIFISFLQNDIFLDPQEF
                     FNSLEDNSQARYSYQLLSQILERLSKQYKITFTNHDELIWHLHNTAFFERQEIFSTPI
                     LFEQKALTIKKFEVYFPDFMGSARQELAQYRQAIGQHDHPEQLEHLMYTILTHAENLS
                     TQLLENRPPIKVLIISNFDHAISLTFVDMLSYYCNNRFTFDIWDELKTSPEILNQTDY
                     DIIVSNFYISGITKKFICRNHLSIMNLVNHLNTLSNEIHLSNTL"
     gene            72490..77814
                     /locus_tag="VVO18_000078"
     CDS             72490..77814
                     /locus_tag="VVO18_000078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK signal domain/LPXTG anchor domain surface
                     protein"
                     /protein_id="HEU5585308.1"
                     /translation="MKHSHKKSFDWYSMQQRYSIRKYYFGAVSVLLGTALVLGAAASV
                     QTVQAEENKQETTNSISVGRGEAATKPAEVSASNKEKTYAAPTVANPVETTPVKTGEV
                     TKPAEKVEEAKDKKEEVTHQDAIDKSKLLTALSRAKKLESKLYTEASAANLQTSIQAG
                     QSLLGKADASEAELSAAESSIQSSIIGLELRSNSNKGTVSETPVAKKANIVEAKEETK
                     PAVTTTERSAVDSAILPISTAAKVETTSAPASTNEILKPSLSLSDARQNPAIRKEDVD
                     RGYSGFRTAGSGFRAAGSGFRAAGPENKPILNPNNTIAFSDISQGLHSFRGIGHSRGG
                     REIHYDVTTVRRGNRLNFTIKYSGPGEFVNNNFILDKGDGFGNPSNATITSSNPRVRE
                     QSKSISQGANYVSHSGYSMTSATSTNTEQTIRFSLPIINPNGDLSVRLKPVTFNVDQG
                     GGGAATSNDPYSNSNYYHRANPLLLDANPYGGTNNKTVSEDIDFQTVYLPTSKLPEGQ
                     TRLVREGEKGQRQITYKVHRFGNETLLGLPISNRVTKEAKPRIMQIGVAKELIDTVKP
                     RVDQNKVGDTNNLTFYLDNDGNGVYTEGVDELVQKIAIKDGAKGEKGDQGERGLTGAQ
                     GTKGEKGDQGERGLTGAQGAKGEKGEQGLQGRDGEQGPKGEDGKTPTVKVTDGQDGTH
                     TITINDGKGGITTTVVRDGFDGASPLVSTHRNEADKTTTVIFYYDLNDNNQFDEGDTK
                     LKEVVIADGKQGPKGDKGDNGKDGFTPEVTVTDNNNGTHTITITQPDNRPSLTTIVKN
                     GEDGKTPKVKAERDDAKKQTTLTFYIDKDGDGSYTAGKDELVQTTVVKDGQDGAAGAS
                     GRDGKEVLNGKADPTTEGKDGDTFVNTQTGDVFVKKGNTWEPAGNIKGPKGDKGADGA
                     KGEKGDRGERGLTGAQGTKGEKGDQGERGLTGAQGTKGEKGDRGERGLTGAQGQAGRD
                     AVTPTVTVKDNKNDGTHTITINDGRGNVASTVVRDGFDGASPLVATQRNEADKTTTVI
                     FYYDQNGNNELDASDKKLKEVIIADGAKGEQGLQGRDGQDGAQGQAGRDGKDVLNGKA
                     NPEVNQGKDGDKYVNTETGDVFVKNNGNWDKEGNIKGPKGDKGERGEDGKTPEVTVTP
                     GKDGHSTDITFTVPGKDPVTFTVKDGKNGKDGRAPKIKVEDITSPSRIRRDTDAAATP
                     TRNGIRVTVYDDVNDNGVYDEGVDKVLNSKDIYNGIDGRDGSAPTITTKDNGDGTHTI
                     TVQNPDSSESTTVVKDGKDGKTANITTTENPDGSHTITVTNPDGSTKETVVKNGKDGK
                     TPKVEVTDNNDGTHTVKVTDGDGNVTNAIIKDGKDGKAATATTTENPDGSHTVTITNP
                     DGTKNEFVVKNGRDGVDGRTPTASVRDNGDGSHTIVITNPEGVTTETTVRDGKSPKVT
                     ITDEQNGTHKISVLNGDGTTTETIIKDGKSPVATVRDNQDGTYTIRVENGNGTVSETT
                     VRDGKSPTAKVVDNGDGTHTITVVNSDGTTTTTTVRDGREPKLEVIDNNDGSHTIKVT
                     GADGKGTTTTIFDGKSPKANIVDNGDGTHTLTIVDSDGREYKSIIKDGKDGKDSVSPT
                     VTVKNNNDGTHVVTITNPDGSKTEMVIKDGKDGKCGCQDKPVTPSNDKPVPPTPNVPT
                     PEVPVKPVPAQPTPNVPTPEVPVQPTPAVPTPEVPVKPVPAVPEQPVVPTPAQPATPV
                     NANPVAPTTGKENRGDKLPETGSQSDYISVLLGSGILLSLYVGRRKED"
     gene            complement(78051..78599)
                     /locus_tag="VVO18_000079"
     CDS             complement(78051..78599)
                     /locus_tag="VVO18_000079"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039625.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU5585309.1"
                     /translation="MSKKVLFIVGSLRQGSFNHQMALEAEKALAGKAEVSYLDYSALP
                     LFSQDLEVPTHPAVAAAREAVLVADAIWIFSPVYNFSIPGTVKNLLDWLSRALDLSDT
                     RGVSALQDKFVTVSSVANAGHDQLFAIYKDLLPFIRTQGVGDFTAARVNDSAWADGKL
                     VLEETVLNSLEKQAQDLVEAIQ"
     gene            78920..79408
                     /locus_tag="VVO18_000080"
     CDS             78920..79408
                     /locus_tag="VVO18_000080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747178.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF5590 domain-containing protein"
                     /protein_id="HEU5585310.1"
                     /translation="MKKRQNKAKNNLLWQYGLGMTILFVVISGSFLYMVSLSMKPYQT
                     AKSEGEKLAQQYAGLEQVDQVDLYNGLESYYSVLGRNKQQEALAVLIGKDDHKIYVYQ
                     LNQGVSQEKAETVSKEKGAGEIDKITFGRYQDKPIWEVKSGSDFYLVDFETGALVNKE
                     GL"
     gene            79405..80592
                     /locus_tag="VVO18_000081"
     CDS             79405..80592
                     /locus_tag="VVO18_000081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU5585311.1"
                     /translation="MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTT
                     PKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKY
                     SLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSTKEDNHFKVTVDQLEAA
                     RTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTP
                     ISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQ
                     YAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAME
                     MKGYTDVTDFTTAILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGS
                     END"
     gene            80585..80950
                     /locus_tag="VVO18_000082"
     CDS             80585..80950
                     /locus_tag="VVO18_000082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU5585312.1"
                     /translation="MIDHFEIKVKDLQISEGFYRSFLAPLDYKLAFKTSSLISFLSPN
                     SPHPGGDFWLTQGTQDPVHFAFLAENKEEVQACYEAGLEAGGRDNGAPGYRSEHPIYY
                     AAFMIDLDGNNIEVVCHKE"
     gene            80966..82312
                     /gene="asnS"
                     /locus_tag="VVO18_000083"
     CDS             80966..82312
                     /gene="asnS"
                     /locus_tag="VVO18_000083"
                     /EC_number="6.1.1.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparagine--tRNA ligase"
                     /protein_id="HEU5585313.1"
                     /translation="MMTKRVTIIDVKDYVGQEVTIGAWVANKSGKGKIAFLQLRDGTA
                     FFQGVAFKPNFVEKFGEEVGLEKFDVIKRLSQETSVYVTGIVKEDERSKFGYELDITD
                     IEVIGESQDYPITPKEHGTDFLMDNRHLWLRSRKQVAVLQIRNAIIYATYEFFDKNGF
                     MKFDSPILSGNAAEDSTELFETDYFGTPAYLSQSGQLYLEAGAMALGRVFDFGPVFRA
                     EKSKTRRHLTEFWMMDAEYSYLTHDESLDLQEAYVKALLQGVLDRAPQALETLERDTE
                     LLKRYIAEPFKRITYDQAIDLLQEHENDEDADYEHLEHGDDFGSPHETWISNHFGVPT
                     FVMNYPAAIKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREEDYDALVAKMDEL
                     GMDRTEYEFYLDLRKYGTVPHGGFGIGIERMVTFAAGTKHIREAIPFPRMLHRIKP"
     gene            82465..82755
                     /locus_tag="VVO18_000084"
     CDS             82465..82755
                     /locus_tag="VVO18_000084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018030687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S6"
                     /protein_id="HEU5585314.1"
                     /translation="MAKYEILYIIRPNIEEEAKNALVARFDSILTDNGATVVESKTWE
                     KRRLAYEIQDFREGLYHIVNVEANDDAALKEFDRLSKINADILRHMIVKIDA"
     gene            82767..83237
                     /gene="ssbA"
                     /locus_tag="VVO18_000085"
     CDS             82767..83237
                     /gene="ssbA"
                     /locus_tag="VVO18_000085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein SsbA"
                     /protein_id="HEU5585315.1"
                     /translation="MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGER
                     EADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQM
                     LESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF"
     gene            83269..83508
                     /locus_tag="VVO18_000086"
     CDS             83269..83508
                     /locus_tag="VVO18_000086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983142.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S18"
                     /protein_id="HEU5585316.1"
                     /translation="MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKI
                     LPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED"
     gene            83803..85203
                     /locus_tag="VVO18_000087"
     CDS             83803..85203
                     /locus_tag="VVO18_000087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional Cof-type HAD-IIB family
                     hydrolase/peptidylprolyl isomerase"
                     /protein_id="HEU5585317.1"
                     /translation="MDAKLRYKAKKIKIVFFDIDDTLRNSKTGFIPTTIPTVFKQLRE
                     KGILTGIASGRGIFGVVPEIRDLKPDFFVTLNGAYIEDKKGQVIYQHQIGKSDVEEYI
                     SWAKQEGIEYGLVGSHDAKLSTRTDMMSEAINPIYPDLDVDPDFHEKEDIYQMWTFED
                     KGDDLHLPDSLSDKLRMVRWHQHSSDIVPISGSKATGVEKVVEHLGLKPEKVMVFGDG
                     LNDLELFDYAGISVAMGISHDKIKEKADYITKTLEEDGIFDALEVFGMVEKELHFPQV
                     DIETVEGPLATIKTNHGDLRIKLFPEHAPKTVANFVSLSKDGYYDGVIFHRIIKDFMI
                     QGGDPTGTGMGGESIYGESFEDEFSEELYNIRGALSMANAGPNTNGSQFFIVQNQHLP
                     YSKKEITRGGWPEPIAEIYANQGGTPHLDRRHTVFGQLADEASYAVLDAIAAVETGAM
                     DKPVEDVVIETIEIED"
     gene            85205..85564
                     /locus_tag="VVO18_000088"
     CDS             85205..85564
                     /locus_tag="VVO18_000088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S1 RNA-binding domain-containing protein"
                     /protein_id="HEU5585318.1"
                     /translation="MKIGDKLKGRITGIQPYGAFVELETGDTGLIHISEIRTGFIENI
                     HETLKVDEEVQVQVVDLDEFTGKASLSIRTLEEEKYQFPRRRRFSSDRFNYGFAPFRR
                     MLPIWTGEALHYLKKKK"
     gene            85618..86367
                     /locus_tag="VVO18_000089"
     CDS             85618..86367
                     /locus_tag="VVO18_000089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390787.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase"
                     /protein_id="HEU5585319.1"
                     /translation="MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPR
                     FPKKGLIVDFCAGNGAVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVI
                     CDDLKNMPAHIQGSKVDMILCNPPYFKVDPHSNLNESEHYLLARHEITTNLEEICHSA
                     QSILKSNGRLAMVHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDG
                     STSGFKVLPPLIVHNDDGSYTPEIEEIYYGS"
     gene            86357..86656
                     /locus_tag="VVO18_000090"
     CDS             86357..86656
                     /locus_tag="VVO18_000090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GIY-YIG nuclease family protein"
                     /protein_id="HEU5585320.1"
                     /translation="MDHKAYMYVLECRDGSYYIGYTTDVRRRLAIHNSGKGAKYTRAR
                     LPVKLIYAQGFASKEEAMSAEALLKRKKRPQKEEFLSENQDRNLLSYFEESWGVL"
     gene            86727..87662
                     /locus_tag="VVO18_000091"
     CDS             86727..87662
                     /locus_tag="VVO18_000091"
                     /EC_number="3.6.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="manganese-dependent inorganic pyrophosphatase"
                     /protein_id="HEU5585321.1"
                     /translation="MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPN
                     EETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRV
                     ANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTT
                     HPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRV
                     AQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKV
                     EAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA"
     gene            87749..88261
                     /locus_tag="VVO18_000092"
     CDS             87749..88261
                     /locus_tag="VVO18_000092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000892254.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoylalanyl-D-glutamate--2,
                     6-diaminopimelate ligase"
                     /protein_id="HEU5585322.1"
                     /translation="MLENGDLIFVRDGSDMGQAIQTSTGNYSHVAIYLDGMIYHASGQ
                     AGVVCQEPADFFESNHLYDLYVYPEMDIQSVKERACRHLGAPYNASFYPDAAAFYCSQ
                     YIAEILPIFETIPMKFGDGEQEISDFWREYYIELGLPVPLNQAGTNPSQLAASPLLQC
                     KERDLHDSDF"
     gene            88286..88894
                     /locus_tag="VVO18_000093"
     CDS             88286..88894
                     /locus_tag="VVO18_000093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1803 domain-containing protein"
                     /protein_id="HEU5585323.1"
                     /translation="MFGELIRYLDQYEDVILREIKSQFPDVAVDKLMEEYIKASLILR
                     ENKRYYLNFPTLESLDSLELDQEIFVREASPVYQALLEQSFETELRNQINAAILVEKT
                     DFARIKMTLSNYFYKVKQQYPLTEKQQELYDILGDVNPEYALKYMTAFLLKFLKKDQL
                     MQKCRDIFVDSLVVLGYIVQNEDRKYELAIDFDKERLTFYLA"
     gene            88995..89189
                     /locus_tag="VVO18_000094"
     CDS             88995..89189
                     /locus_tag="VVO18_000094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEU5585324.1"
                     /translation="MSLENKLEQATGAVKEGFGKVTGDSKTELEGAVEKTVAKAKDVV
                     EDAKGAVEGAVEGLKNVFTK"
     gene            complement(89235..90680)
                     /locus_tag="VVO18_000095"
     CDS             complement(89235..90680)
                     /locus_tag="VVO18_000095"
                     /EC_number="6.3.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-
                     lysine ligase"
                     /protein_id="HEU5585325.1"
                     /translation="MIKIETVLDILKKDGLFREIIDQGHYHYNYSKVVFDSISYDSRK
                     VTEDTLFFAKGAAFKKEYLLSAITQGLAWYVAEKDYEVGIPVIIVNDIKKAMSLIAME
                     FYGNPQEKLKILAFTGTKGKTTAAYFAYNILSQRYPTALLSTMNTTLDGTTFFKSSFS
                     TPENIDLFDMMAQAVKNGRSHLVMEVSSQAYLVHRVYGLTFDVGVFLNITPDHIGPIE
                     HPSFEDYFYHKRLLMENSRAVIINSDMDHFSVLKEQVEDQDHDFYGSQFDNQIENSKA
                     FSFSATGKLAGDYDIQLIGNFNQENAVAAGLACLRLGASLEDIKKGIAATRVPGRMEV
                     LTQKNGAKVFIDYAHNGDSLKKLINVVETHQTGKIALVLGSTGNKGESRRKDFGLLLN
                     QHPEIQVFLTADDPNYEDPMAIADEISSYINHPVEKIADRQEAIKAAMAITNHELDAV
                     IIAGKGADCYQIIQGKKESYPGDTAVAENYL"
     gene            90786..92408
                     /locus_tag="VVO18_000096"
     CDS             90786..92408
                     /locus_tag="VVO18_000096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEU5585326.1"
                     /translation="MSHENNHQQAQMLRGTAWLTASNFISRLLGAVYIIPWYIWMGAY
                     AAKANGLFTMGYNIYAWFLLVSTAGIPVAVAKQVAKYNTMREEEHSFALIRSFLGFMT
                     GLGLVFALVLYVFAPWLADLSGVGKDLIPIMQSLAWGVLIFPSMSVIRGFFQGMNNLK
                     PYAMSQIAEQVIRVIWMLLATFIIMKLGSGDYLAAVTQSTFAAFVGMVASFAVLIYFL
                     AQEGSLKRVFETGDKINSKRLLVDTIKEAIPFILTGSAIQLFQILDQLTFINSMSWFT
                     NYSNEDLVVMFSYFSANPNKITMILISVGVSIGSVGLPLLTENYVKGDLKAASRLVQD
                     SLTLLFMFLLPATVGVVMVGEPLYTVFYGKPDSLALGLFVFAVLQSIILGLYMVLSPM
                     LQAMFRNRKAVLYFIYGSIAKLVLQLPTIALFHSYGPLISTTIALIIPNVLMYRDICK
                     VTGVKRKVILKRTILISLLTLVMFLLIGTIQWLLGFFFQPSGRLWSFFYVALVGAMGG
                     GLYMVMSLRTYLLDKVIGKAQADRLRAKFKLS"
     gene            92609..94570
                     /locus_tag="VVO18_000097"
     CDS             92609..94570
                     /locus_tag="VVO18_000097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5585327.1"
                     /translation="MKKSKSKYLTLAGFVLGTGVLLSACGNSSTASKTYNYVYSSDPS
                     SLNYLAENRATTNDIVTNLVDGLMENDQYGNYVPSLAEDWTVSQDGLTYTYKLRKDAK
                     WFTSEGEEYAPVTAQDFVTGLQYAADKKSEALYLVQDSVAGLDDYITGKTSDFSTVGI
                     KALDDQTVQYTLARPEPYWNSKTTSTILFPVNADFLKSKGDDFGKVDPANILYSGPFL
                     MKAFVSKSVIEYKKNPNYWDAKNVFVDDVKLTYYDGSDQDALVRNFTDGAYSYARLYP
                     NSSSFEGIKEKYKDDIIYSMQDATSYYWNFNLDRQAYKFTSKTTDIEKKSTQEAVLNK
                     NFRQAINFAYDRTSYGAQTQGEDGATKILRNLVVPPTFVSIKGKDFGEVVASKMVNNY
                     GKEWQGINFADGQDPYYNPEKAKAKFAEAKKELEAKGVQFPIHLDATVDQASKKGIQE
                     VSSMKQSIEAALGTENVVIDIQQLSTEDYDNSSYLAQTAIQKDYDLYNGGWSPDYLDP
                     STYLDIFSVKNGGVLQNLGLDPGEANDKAKAVGLDTYTQMLEEANKEQDPAKRYEKYA
                     DIQAWLIDSSLAIPNVSLGGTPSLRKTVPFSAPYSLAGNKGVESYKYLKVQDKIVTTD
                     EYAKAREKWLKEKEESNKKAQEELAKHVK"
     gene            94742..94975
                     /locus_tag="VVO18_000098"
     CDS             94742..94975
                     /locus_tag="VVO18_000098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter"
                     /protein_id="HEU5585328.1"
                     /translation="MKLKLLRVDTKVIMWSFLLVLSSLLALLLPLILKGLIDGSSIEN
                     IGSKVFQSFLIFIGQALFSSIGYYLFSQSGEKR"
     gene            94981..96423
                     /locus_tag="VVO18_000099"
     CDS             94981..96423
                     /locus_tag="VVO18_000099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860566.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585329.1"
                     /translation="MRKKVIEGLIYAEKSFFDKSQSGELTSAIVNDMSVIREFLITTF
                     PNIILSLVMVLGSIVVLFSLDWNLSLLLFITLPCMMFIILPLSNISEKYSRRLQEEIG
                     FLTGQLTEKIQEHELIKTNQAEKSVQDVLDNCIERVQNNSLKSDRVTSFETPFALLFI
                     FATIVVMLTYGGYRVSAGYISVGTLVSFLIYLFQLLNPISNIANFVTIYSSSKGSSVA
                     LENLLAVPKEKFEGGKSVSGQGLNFNHVYFGYDENRPVLKDITCSIFKGQKIAFVGPS
                     GSGKSTIVRLLERFYKPLSGDILMEQSSIYDFNLKEWRSKIAWVSQNNAVLSGSIRDN
                     LCLGLNRLVTDDELMKVLDLVSLGDEIRSMKEGLDTEVGERGRFLSGGQSQRLQIART
                     YLKDAEILIFDEATANLDADSEYAIISSLYSVLKEKTVVIIAHSLSTVKDVDCIFFLE
                     EGKITGSGTHKELLENHERYARFVQEQMIE"
     gene            96581..97675
                     /locus_tag="VVO18_000100"
     CDS             96581..97675
                     /locus_tag="VVO18_000100"
                     /EC_number="2.5.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEU5585330.1"
                     /translation="MSKELHINTILAQAGIKSDEATGALVTPLHFSTTYQHPEFGRST
                     GFDYTRTKNPTRSKAEEVLAAIESADYALATSSGMSAIVLAFSVFPVGSKVLAVRDLY
                     GGSFRWFNQVEQEGHFHFTYANTEEELIAELEKDVDVLYIETPTNPLMLEFDIEKLAK
                     LAHAKGAKVVVDNTFYSPIYQRPIEDGADIVLHSATKYLAGHNDVLAGVVVTNSLELY
                     EKLFYNLNTTGAVLSPFDSYQLLRGLKTLSLRMERSTANAQEVVAFLKDSPAVKEVLY
                     TGRGGMISFKVADETRIPHILNSLKVFSFAESLGGVESLITYPTTQTHADIPAEVRHS
                     YGLTDDLLRLSIGIEDARDLIADLRQALEG"
     gene            97683..98849
                     /locus_tag="VVO18_000101"
     CDS             97683..98849
                     /locus_tag="VVO18_000101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU5585331.1"
                     /translation="MGKYDFTSLPNRLGHHTYKWKETETDSEVLPAWIADMDFVVLPE
                     IRQAVQTYADQLVYGYTYASEDLIKEVQKWEATQYGYNFDKEALVFIEGVVPAISTAI
                     QTFTKEGEAVLINTPVYPPFARSVKLNNRRLITNSLVEKDSLFEIDFDQLEKDLVEEE
                     VKLYVLCNPHNPGGRVWEKEVLEKIGQLCQKHGVLLVSDEIHQDLTLFGHKHQSFNTI
                     NPAFKNFAIVLSSATKTFNIAGTKNSYAVIENPKLRLAFQKRLLANNQHEISGLGYLA
                     TEAAYRYGKDWLEELKQVFEDHINYVMDLFGKETKIKVMKPQGTYLIWLDFSAYDLTD
                     ETLQELLRNEAKVILNRGLDFGEEGSLHARINIAMPKSLLQEVCQRIVATFAKR"
     gene            98942..102040
                     /locus_tag="VVO18_000102"
     CDS             98942..102040
                     /locus_tag="VVO18_000102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096241.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU5585332.1"
                     /translation="MAKLIPGKVRIEGVALYETGKVDIIKEKNNRLYARVAEEELRYS
                     LEDDLVFCACDFFQKRGYCVHLAALEHFLKNDERGQEILWSLEEGHEEKEAVETKVTL
                     GGKFLDRILSPKSECAYELSAVGQVEAGTNHILWTLRIGQINSQKYYVIRDIPLFLRI
                     VEQRKSYMIGKIYEESLSWEAFDDASQELLTFLHGLTEEGLVSDLFFQNQGRHLFFPL
                     TFFEQGVNLLMALPHFQFDHQVDSYQTLLFQDMHADANLFAFTVTEYSDYFEMEISES
                     PRVNVFYQGAVLFHKGQVYFLTDQQMRLLKEIKALPVGQQGKKYLQFDSSDRDKLASC
                     LTLFIQMGTVSAPERLQIKTFAPSFYFDREEDNRIRLEIQFDYGNRQVSSRQELEELP
                     FSSDADLEERIFQVCLAAGFEADFQSWRQALKAESVYHFFHDIIPVFEKLGHVDLSDK
                     LEELYSLASPQVQIASKGGLLEIQFDFQDIAQEEIDQAMQALVANQDFYIDSSNQVYF
                     FDEETKKIRQNLQELGQFELKDGTLQARKSLAYSLAHLFEGRDRVSFSQEFQNLAQDL
                     THPEDFPRQATQVQADLRDYQEKGIGWLQMLHHYGFGGILADDMGLGKTLQTIAFLTS
                     QVTKESRVLILAPSGLIYNWADEFQKFAPQLDVAVVHGLKASREEILAESHQIYVTSY
                     ATFRQDSEFYQGMAFDFLFLDEAQVMKNAQTKIAQTLRQFVVPSVFALSGTPIENHLG
                     ELWSIFQIVMPGLLPSKKEFMKLPAERVAQFIKPFVMRRKKEEVLTELPDLIEVVYKN
                     ELEDQQKAIYLAQLQQMRDHLAQVSEQEFQRSRVEILSGLMRLRQICDTPALFMEDYQ
                     GASGKLDSLRDLLVQVADGGHRVLIFSQFKGMLEKIEQELPDLGLTSFKITGSTPAKE
                     RQDMTKAFNQGERDAFLISLKAGGVGLNLTGADTVILVDLWWNPAVEAQAIGRAHRMG
                     QEETVEVYRLVTKGTIEEKIQELQEQKKHLVSQVLDGTESRGSLTLAEIREILGISEA
                     ST"
     gene            102088..102705
                     /locus_tag="VVO18_000103"
     CDS             102088..102705
                     /locus_tag="VVO18_000103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine gamma-synthase"
                     /protein_id="HEU5585333.1"
                     /translation="MKQERFPLVSDDEVMLTEMPVMNLYDESDLISNIKGEYRDKNYL
                     EWAPITEEKPVKPIEKQVEKPKKAPLGVKKEGKSYAEVAREEARADLKKKRSANYLTQ
                     DFSLARRHSQPSLVRQGNQPTTPFQKENPGEFVKYSQKLTQSHYILAEEVHSIPTKNE
                     EVSAPAPKKNNYDFLKKSQIYNKKSKQTEQERRVAQELNLTRMTE"
     gene            102716..104050
                     /locus_tag="VVO18_000104"
     CDS             102716..104050
                     /locus_tag="VVO18_000104"
                     /EC_number="6.3.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="HEU5585334.1"
                     /translation="MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGL
                     EQAGITILPFDEKNLDGDMEIIAGNAFRPDNNVEIVYADQNGISYKRYHEFLGSFMRD
                     FVSMGVAGAHGKTSTTGMLSHVLSHITDTSFLIGDGTGRGSANAKYFVFESDEYERHF
                     MPYHPEYSIITNIDFDHPDYFTSLEDVFNAFNDYAKQITKGLFVYGEDAELRKITSDA
                     PIYYYGFEAEGNDFVASDLLRSTTGSTFTVHFRGQNLGQFHIPTFGRHNIMNATAVIG
                     LLYTAGFDLNLVREHLKTFSGVKRRFTEKIVNDTVIIDDFAHHPTEIIATLDAARQKY
                     PSKEIVAVFQPHTFTRTIALLDDFAHALNQADAVYLAQIYGSAREVDHGDVKVEDLAN
                     KINKKHQVITVENVSPLLDHDNAVYVFMGAGDIQTYEYSFERLLSNLTSNVQ"
     gene            104060..104524
                     /locus_tag="VVO18_000105"
     CDS             104060..104524
                     /locus_tag="VVO18_000105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585335.1"
                     /translation="MEIPIKIIQASKSDLPEIGALQTSSFPAEKQQLSHILEESIRKC
                     ADTFLLARDENQLLGYILSSPQSDNPQYLKVHSLVIESDHQRQGLGTLLLAALKEVAV
                     ELDYKGIRLESPDELLSYFEMNGFVDEEATLLYATSQGYSMIWFNPFYLEEQ"
     gene            104521..105015
                     /locus_tag="VVO18_000106"
     CDS             104521..105015
                     /locus_tag="VVO18_000106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000702438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585336.1"
                     /translation="MKIRQARLEDLDRIVELEFENFSVEEAIPPSVFEAHLREIQTSF
                     LVAEKEGRIMGYIEGPVGLHRHLQDQSFTEEIKDYSHEPGGYISVTCLSIAKEAQGLG
                     LGQKLLTALKEVALEDERDGINLTCHDYLIAYYEKHGFVNEGQSQSTFAGETWYDMVW
                     EMKK"
     gene            105096..106751
                     /gene="mltG"
                     /locus_tag="VVO18_000107"
     CDS             105096..106751
                     /gene="mltG"
                     /locus_tag="VVO18_000107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endolytic transglycosylase MltG"
                     /protein_id="HEU5585337.1"
                     /translation="MSEKSREEEKLSFKEQILRDLEKVKGYDEVLKEDEAVVRTPANE
                     PSTEELMADSLSTVEEIMRKAPTVPTHPSQGVPASPADEIQRETPGVPSHPSQDVPSS
                     PAEESGSRPGPGPVRPKKLEREYNETPTRVAVSYTTAEKKAEQAGPETPTPATETVDI
                     IRDTSRRSRREGAKPVKPKKEKKSHVKAFVISFLVFLALLSAGGYFGYQYVLDSLLPI
                     DANSKKYVTVGIPEGSNVQEIGTTLEKAGLVKHGLIFSFYAKYKNYTDLKAGYYNLQK
                     SMSTEDLLKELQKGGTDEPQEPVLATLTIPEGYTLDQIAQAVGQLQGDFKESLTAETF
                     LAKVQDETFISQAVAKYPTLLESLPVKDSGARYRLEGYLFPATYSIKESTTIESLIDE
                     MLAAMDKNLSPYYSTIKSKNLTVNELLTIASLVEKEGAKTEDRKLIAGVFYNRLNRDM
                     PLQSNIAILYAQGKLGQNISLAEDVAIDTNIDSPYNVYKNVGLMPGPVDSPSLDAIES
                     SINQTKSDNLYFVADVTEGKVYYANNQEDHDRNVAEHVNSKLN"
     gene            106822..107304
                     /gene="greA"
                     /locus_tag="VVO18_000108"
     CDS             106822..107304
                     /gene="greA"
                     /locus_tag="VVO18_000108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018370745.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription elongation factor GreA"
                     /protein_id="HEU5585338.1"
                     /translation="MAEKTYPMTLEEKEKLEKELEELKLVRRPEVVERIKIARSYGDL
                     SENSEYEAAKDEQAFVEGQISSLETKIRYAEIVNSDAVAQDEVAIGKTVTIQEIGEDE
                     EEVYIIVGSAGADAFAGKVSNESPIGQALIGKKTGDTATIETPVGSYDVKILKVEKTA
                     "
     gene            107632..108030
                     /locus_tag="VVO18_000109"
     CDS             107632..108030
                     /locus_tag="VVO18_000109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585339.1"
                     /translation="MENKESHKSQEIGNLIRVYNRSKREEAESEPLNLYVEDEKGNLL
                     AGLIAETFGNWLEIEYLFVKEELRGQGIGSKLLQQAESEAKNRNCCFAFVNTYQFQAP
                     DFYQKHGYKEVFSLQDYLYIRQRYYYQKNL"
     gene            108475..>108913
                     /locus_tag="VVO18_000110"
     CDS             108475..>108913
                     /locus_tag="VVO18_000110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEU5585340.1"
                     /translation="MQDNYTTKAKHLTIDSRRLIERWKKEGKSNREIASLLGKVPQTI
                     HTEIKRGTVRQCLGKGRFKEVYSADYAQQSYENNRKRSVKKSSLTKELKEKILHYHNQ
                     KFSPEMMVMAKGVNVGISTIYYWIHHGKLGLSKQDLLYPRKGKA"
BASE COUNT        32583 a        20223 c        24572 g        31535 t
ORIGIN      
        1 gttttgtaag ttacatctag ttgagagagg tatgaatgat ttgggataaa aaatgcaaat
       61 agtagcaaat caataactgc aattgctata aaatggattc tatagagttt tttcatgaca
      121 agacctccct cttttatcta acttcattct actctaaaag aatgggagtt acaactaaaa
      181 tgataaaaat agcagagggg agattctctt aagttggcta gtattcttta tttgagtttc
      241 cttctattat ctaacttctt catcattcca gacaaataaa gctccgattg cattgaggat
      301 ataaaagatg tatttaccga tattggcgaa gtttccttga ataccagctt ttgtcagctg
      361 aacgaaattg taaatcaacc aaaagcccca ctgtcgctca ttgccaatgc attcaaagca
      421 ttggcaatga gggacagtgc aaaggcaata gttgttacgt aggcaaggag attcatcttg
      481 cccccatatc cgatatagtt ggtcacaaag gcaaagagga aggcgatgat ggaaatgatg
      541 atggccgcca attttacctg tttttggctc atttggttgg gtctgccttc ttgcgaagct
      601 ttccatttct ttatagcaaa ggtataaatg agtaaggtga cgggataggt aatgatggcc
      661 gccttatttc taaggatata atcaatagca ccggacaaaa tggtattaac aataccaaag
      721 taatttcccc atttgcttaa tttccccgtg aaacgagtgg acaacatgga aatcccaacg
      781 ttggttacgg aaatcaatcc aaagggtaca agagctgtcc atagtcccca gtctacaaat
      841 ttatcgaggc gtgagttgag ataaccagat gcaatcgcaa tcccaacgac caaagcaacc
      901 ccgaagaggt caaatcattt agatgtagca aaaattttta gtgatttttt cataggttaa
      961 actacctttc tttttttcaa atactctccc atttttttca aatattctac caccaaatga
     1021 aagtaaaata aaatgataga aataaaaccc tgaaaataaa actttcaggg ttggtagggg
     1081 acttgagaaa ttagttgatt ttctcgacat agagttgttt tgcaatgtcc atattcactt
     1141 gtaaatcctc gtcgttactg aggatagtga aggtattgct gaagccatca aactgcttga
     1201 cttggagctg gtcaccgatg tgaagtgagt gcttgtccag ataatggaga atgtcaaaac
     1261 tatcgtgcac ccgagtcagg cggtaggcgc cagcttcctt gatatcagct agtgggaggt
     1321 tattgatttc aacgaggagt tctcccttgg caggaatagt tcctccgtgg gggcaggttt
     1381 tagggaaacc tagcagttta tctagtcttt ccacgaacag gtcagagaca gtgtgttcca
     1441 agacctcagc ttcctcgtga atctggtcac ttgtatagtc taaatgatga actagaaaaa
     1501 cttcaatcaa gcggtgctta cgatagagct cagagaccag tttgagaccg aggtcagtca
     1561 gtagatagcc acattccttg tcctttagga tgagattttc acttttcatt cgtttgatca
     1621 tttcagttac ggcaggggga gagacttgca tgcgagccgc aatttccttg ttggtaatct
     1681 tatgcaggtc tatgccaatt tcataaatac attttagata gtcttctttg tttggggtca
     1741 ttcgtttcct cttgtctaat atctttatct agtatatcaa aaaaagctag atttctctag
     1801 ctgtgacttt ttatgttata cttattgcaa gagaaaaaac gaggagatgg atatgacgaa
     1861 aatagctctt ctttcagata ttcatggaaa taccaccgcc ttggaggctg ttttggcaga
     1921 tgctcggcag ataggagtgg atgaatactg gcttttggga gatattctca tgccagggac
     1981 agggcgtaga aggattttgg acttgttgga tcaactaccg attacggcta gagttttggg
     2041 aaactgggaa gacagtcttt ggcatggtgt ccgtaaggaa ttggatagta ctcgccccag
     2101 tcaacgctat ctcttgcgcc agtgccagta tgttttagag gaaatttccc tagaagaaat
     2161 tgaagtgctc cacaatcaac ctcttcaaat tcatcgtcag tttggggatt tgacggtggg
     2221 aattagccat catctgcctg ataagaactg ggggcgagag ttgattcata ttggcaaaca
     2281 agaggagttt gaccgcttgg tgactcatcc tccctgtgat attgctgttt atggacatat
     2341 tcaccagcag ttgcttcgtt acgggactgg tgggcaattg attgtcaatc cgggttcgat
     2401 tggccaacct ttctttttgg acgctcagct acggaaggac ttgcgggccc agtatatgat
     2461 tttggagttt gatgacaagg gcctggtaga tatggacttc cgacgggtag actacgatgt
     2521 ggcagctgaa ttgcagctgg ctaaagacct gagacttcct tattttgagg tttactatga
     2581 aagtctggtc aatgggatcc accatactca tcatcaggaa tttttgagag aattggctca
     2641 gaaagagggc tgcgatcggg agttagacga ctggttgaaa agtggtaacg attgacatta
     2701 caactaaaaa gggtataata atagaaaaag aagagtagag gcagggtagc ctcgtaaaaa
     2761 ggagaagagg atgcaaattc caagtagatt taccattgcg actcatatgc tgataatcat
     2821 tgccctcgag gggaaggaaa gcaaggtgac cagtgatttt ctggctgcta gtgtcggggt
     2881 caatcctgtc attatcagaa agatcttgtc ccagttgaag aaggcagagc tgatttcagt
     2941 agcgcgtgga acgggcggaa cagagattgt caaggacctt aaggatatta gtcttttaga
     3001 tgtttatcag gcggtcgaat gtcttggtaa gacaggtcaa ctcttcagtt tccatgacaa
     3061 tccgaatcca aattgccctg taggagctca tattcatgat gttttggatc aaaaattgga
     3121 gagaattcag ttgactatgg aggcagaact tggtcaaatc agtctagaaa aagtcgtggc
     3181 cgatgcagag agtcagatga aggattaaga gggataaatg ccctcttttt tctttggata
     3241 attatgataa aatgtagcta ttaaaggagt aagaaatgta tctcgttata ggaattgtat
     3301 tagcctttat agtgtcattt tggaaggata atagaagttt gtggaatcca gtattatttt
     3361 tattatccct catttcaagt tatttttatc tatcctacct tttttataaa aatggatacg
     3421 agaatgttca gttagctttt tatgtatttg cctttgtctt acttcctttt ttgctttttc
     3481 taagtggcat ctttttaatc tataatgggg tcattttgtt gaagcgagag ggacgttcca
     3541 agcccaatta tctttcaatg ctatttgatt tttattgact attagattct atttaaaaag
     3601 acttagaatg cacatgaaag tatgtattct aggtcttttg ttttgtatac atttaatttt
     3661 caagagtatt atctattttt ccatgcctgg taacgagtat caatcaataa ctgggtaagg
     3721 cgacccaagg tttctctttc ttctggagtg agggattgag cttggacaaa gagatgatga
     3781 atgtattcaa gcgcctttaa ggaagccaag tcattgatag agctaatacc agcctcaaga
     3841 atagtgccaa agaagaggtc gaagtagagc tgaagttctt cgtcagggac tgtggccacc
     3901 cattctttaa aggttgtgtc tacttgctgg ctatcactgt tggtcttatc cagttggacg
     3961 aagtgcttgt cctcaatctg ccaactaaag gtatcgtgct gggcgatgcc acccagggca
     4021 gtactctgaa cgatgatttg gtgagcagga atttccagca tcataccgat aatggaacct
     4081 tgtggaatga atatcttgct tctatccatt atcctttgat aacccgcagt ctgtgtcaat
     4141 tcttgatgga gaccaggtgc atcaaatgta taaactgctg tgatctgatt ttgcaaactt
     4201 tgctcaattt ggctagcagc atagatagcg agatttcctc ccttggaatg cccggccaga
     4261 ataacctttt gcttaggatg atgagcaaaa aagttcttta aatagcgaag ggcgtgcttt
     4321 tgagcaggaa tttccttcat ataggtcagg tggaaatctt ccttccagcc aatgatactg
     4381 tcatctgtcc cacgaaagac aatcagatag gtatcgaggc tgacacgata agtcatagcc
     4441 gcaaattgct tttgcagttc agggtagatg tcgttgataa aatgggagag tttgcaattt
     4501 ttgaagcgct tgtgttgagc caattcatct aataattgaa ggcgattttt gctagtaagc
     4561 atggtgggat ctcttggaac ctgaggtgct agatctaaaa gacgttgagg aagtgtggag
     4621 accagattat caaaggagag gtaggtgatt tctattaagg ttagaatgtc taactcattc
     4681 aagggaaggt cgtaataaga atcatatgcg acatctttca gatagtcaaa aatattggcc
     4741 ataagagctc ctttcttttt atttatctta gcaaatttcc ctcaaattag ctagtagcat
     4801 tgcctgtttg tactggctaa aaacaggcta tttcaaattc agtttcagac catctggcat
     4861 ggaaaaatct gttataataa tagaaaagga gaagcgcatg cacaagattt tattaataga
     4921 agatgatcag gtcattcgtc aacaggtcgg gaaaatgctc tctgaatggg gatttgaagt
     4981 ggtcctggta gaagacttta tggaagtttt gagtctattt gttcagtcgg aacctcatct
     5041 ggtcctcatg gatattggtt tgcccttgtt taatggttat cactggtgtc aggaaatccg
     5101 caagatttcc aaggtaccta tcatgtttct ttcttcgaga gaccaggcta tggatattgt
     5161 catggcaatc aatatggggg cggatgactt tgtgaccaag ccttttgacc agcaggttct
     5221 tttagctaag gttcagggct tgttgcgtcg ttcctatgag tttgggcgtg atgagagttt
     5281 gctggaatat gctggtgtta tcctcaatac caaatccatg gatttacatt atcaagggca
     5341 agtcttgaat ttgaccaaga atgaattcca gattttacgc gtgttatttg agcatgcagg
     5401 caacatcgta gcacgtgacg acctgatgcg ggaactttgg aacagtgact ttttcattga
     5461 tgataatacc ctctctgtca atgtggctcg tttgcgtaaa aagttggagg agcagggatt
     5521 ggtaggattt atcgagacca agaaaggaat agggtacgga ttgaagcatg cttgattgga
     5581 aacaattttt tctagcctat ctgcgctccc gtagtcgtct ttttatctat ctgctttctt
     5641 tggcatttct tgtcttactc tttcagtttt tatttgccag tctaggaatt tacttcctct
     5701 actttttctt cttgtgttgc tttgtaacca tcttattttt cacttgggac atattggtgg
     5761 aaacgcaggt ctatcgccag gaacttctct atggagagag ggaagccaag tctcctttgg
     5821 aaatagcttt agcagaaaaa ttagaagcgc gtgagatgga actctatcag cagaggtcaa
     5881 aagcagaaag aaaactgacg gatttgctgg attactatac cttgtgggtc catcagataa
     5941 agacccccat tgcagccagt caactcttag ttgcagaagt ggtcgaccgc caactgaagc
     6001 agcagctaga acaggaaatt ttcaaaatcg actcctatac caacctagtt ttacagtacc
     6061 tgcgtttaga aagtttccat gatgatttgg tcttaaagca ggttcaaatt gaggacttgg
     6121 tcaaggaaat aattcgtaaa tatgctcttt tctttattca aaaaggctta aatgtcaatc
     6181 tacatgacct tgataaagaa atcgtgacgg ataaaaagtg gctgctagtg gttattgagc
     6241 aaatcatctc aaacagtctc aagtacacca aggaaggtgg tctggagatt tatatggatg
     6301 accaagagct ttgtatcaaa gatacgggaa tcgggataaa aaacagtgat gtcctccgag
     6361 tatttgaacg tggcttttca ggatacaatg gccgtttgac ccagcagtcc tctggacttg
     6421 gcctttatct atctaagaaa atttctgaag aactggggca ccagattcgt atcgagtctg
     6481 aggtcggaaa aggaacgaca gtgcggattc agtttgctca agtgaactta gtccttgagt
     6541 aaaaatagat gagaaaaagc ctccagattg gaggctttta tgctagactc ttatttctca
     6601 acgcgtgatt tgttggcgat atcagctagg atagcttgaa caaaattatc aactgagaca
     6661 gtttgtgttt ctttttggcc gtagcgacga acgttgactg tttcgtcttc catttctttg
     6721 tctccaacaa ttaattggta aggaatcttg ctggtttgtg aagcacggat cttgaactgc
     6781 attttttcat tgcgctcatc tacgtctgca cggacaccgc ggtcacggag tttcttggct
     6841 acttcccaag cgtagtccac gtgtttttcg ttagatactg ggataagggt tacttggtgt
     6901 ggtgccagcc atgttgggaa ggcacccttg tagttctcaa tcaagatagc tgtgaagcgt
     6961 tccatagttg agataacccc acggtggatc atgactggac ggtgatcttc gccatcagct
     7021 ccgatgtatt tgaggtcgaa gcgttctggc aacaagaaat caagttggat agtagaaagg
     7081 gtttcttctt ttccaagggc agttttaatc tggatatcca attttggtcc gtagaaggcc
     7141 gcttcacctt cggcttcaaa gtagtccacg cccatttcat caagagctgc acgaagcatg
     7201 gtttgggcat tttcccacat ctcatcgtta tcaaagtact tatgagtatc ttgagggtca
     7261 cgaagagaga ggcggaagcg gtagtcagtc aagttgaagt cttcataaac atcgataatc
     7321 aactgaaggg cacgttggaa ttcttcttgg atttgttctg gagtaacgaa taggtgaccg
     7381 tcgttgagtg acatttcacg tacacgttga aggccagtga gggcaccaga tttttcgtaa
     7441 cggtgcatca taccgatttc agcgatacgg attggcaatt cacggtaaga gtgaacatgg
     7501 tgtttgaaaa cttggatgtg gtgcggacag ttcattggac gaaggacaaa ttcttccccg
     7561 tcacccatgt ccatggttgg gaacatgtct tcttggtaat gatcccagtg gccagaagtc
     7621 ttgtaaagct caacagaagc aagtggtgga gtgtagacgt gttggtagcc agaagccaac
     7681 tctttgttta cgatgtagcg ttccaattca cgacggatag tcgcaccatt tggcaaccag
     7741 aatggcaaac cttgtcccac ttcttgtgaa atcataaaga ggtcaagctc tttaccaagt
     7801 ttacggtggt cacgttcctt agcttcttca cgcatttgaa ggtagttttt caagtctttc
     7861 ttttcaaacc aagctgtacc gtagatacgt tgcatcatag cgttgtcgct gtttccacgc
     7921 cagtacgcac cagctacatg gagaaggtgg aagatttgga tacgacctgt tgatggaacg
     7981 tgaggtccac ggcagaggtc tacatattca ccctgacgat agatagtcaa accgccttcg
     8041 tcttctgagt gttcttcaat caattccaac ttgtaagggt catttttgaa gatttcacgt
     8101 gcctcgtctt tagtcacttc ttcacgaata gatgggaagt tttctttgac gattttttgc
     8161 atttcttctt cgatacgagg aaggtcttcg ttagagattt gaccagctgt gttgtcagta
     8221 tcgtagtaga aaccatcttc gatggctgga ccaactccca agtgaatgtc tgggaaaaga
     8281 cgacgagctg cttgggcgaa caagtgagct gctgagtggc gcaagattgg aagggcatct
     8341 tcgtgatcag gtgtcacaat ttcgatgctt ccatcttcag tgatagcgcg agtagtgtcg
     8401 atgagtttgc cgttgaattt accagccaag gcttttttag ctagggaatt gctgatagat
     8461 tgggcaattt caaaagttgt tacgccagat tcgaattcac gaacagcgcc atctgggaaa
     8521 gtaatgttaa tcatgatgtt ctcctttttt attatttcat agtttctaag cattgatttt
     8581 ttatcatcag actacttcca agtcctaacg ttcaattgct tttctttatc agagaggaag
     8641 ttttccattt ccgtcagaat gtctatatcc aaacgttgag aaagttctaa tagccaccag
     8701 atattttctg aaagtttttg ttccagtgtg tagggtgttt catcatagta gcgtccttgc
     8761 tttgtcatca ccagtcgttg gaaatttcca atatcattag ataaagccaa ggggtcttct
     8821 tctaccgtcc acttggaatc atgatgctta acttccagtt cgtgataagc ttgtcggatt
     8881 gcccaactgc gctccactaa ttcttgcaac tccataatta gtatcctaat aaaaaaatgc
     8941 gacatcctcg aaaggacgtc gcaacgtggt tccaccttca tttatgtacc tcaaaagaga
     9001 gggacacctc tgattggctc taacgtggcc accgttttat gttttcataa aaaactcaag
     9061 agtagtatca gtttagactt cctatgcgtt tccagcaacc acgcactctc tagtagaaag
     9121 ggactaagtg acttgtctct atggattatt atagcatgat tgtgagattt ttcaaggatt
     9181 ttgtgaaagt tttttgtttt tcattttttg tagaatatgc ttgatgctaa taccagaatc
     9241 catgcccacc agagcaactg tttcatagat tagcaagtaa attagtataa actcaccaaa
     9301 ggttatgata gtaaagtaaa agagcagtcc gttaccaact aaccatcaaa gtgagaaacg
     9361 gaaacggtag ctatagagta acgatacaat caagattacc agaggtgtaa agaagagaag
     9421 attgtttata tagagttcct tgagtgtaag ggggtcagaa acaactagta agaacaactc
     9481 ataaagtggc caataaaaga ataatatgac cagatagtag gggagatggg aatagaatct
     9541 acgcatgata atcacctcgt tttaaaaaaa cagacaactt agatctcttg ctatgattat
     9601 tatagcatgt ttaaaacaag aaagtaaatt tgttggcaaa gaagattttt ttttcactag
     9661 aatcatggtt agttttcttg gtagaaatat tttgataata attaagcaaa actattgaca
     9721 ttgattatta agagtgtcac aattgttgta actaaaataa ttacaataag agaggtataa
     9781 aaaatgaaac tagcagttat tgcagcaaat ggacaagcgg ggaaagcaat tgttgaagaa
     9841 gtagtcaaac gaggacatga agtaacggct attgttcgtt ctgaaaacaa aagtcaatct
     9901 gagtctatta ttaaaaaaga tttatttgag ttgacaaaag atgatcttac tggatttgat
     9961 gctgttattt cagcgtttgg tgcttataca ccagatacgc taccgctcca cagcaaatca
    10021 atcgaactat ttaatcagct tcttgctgga acacagacac gttttctagt tgtaggggga
    10081 gcaggaagtc tttatataga tgaaacaaaa acgacacgac ttttagatac gtctgatttt
    10141 cctgaagaat ttaagtcact agcaaaagct caagcggatg aattggatct tcttcgtaca
    10201 aaaaataatc tcaactggac ttttgtcagt cctgctgtag attttattcc cgatggtgaa
    10261 aaaacaggaa actacattct agcaggagaa atttttacta ctaatgaaaa aggaataagc
    10321 cagattagtt atgcagatta tgctattgga ttggtagatg aacttgaaaa aggtcatcat
    10381 ataaaagaac gtatctcttt acttgaaaaa taataactat gagagtatta atgtttgaca
    10441 gaaaatttaa atcttggtaa aatagggatt gtcgtaaaga caaataactt cttcttggtt
    10501 acaggcatgc caacctgtca ctcggatgaa gccaaataaa aaggagaaac atcatggcaa
    10561 tctcaaaaga gaaaaaaaat gaaatcattg cacaatatgc acgtcacgaa ggtgatacag
    10621 gttcagtaga ggttcaagtt gctgtcctta cttgggaaat caaccacctt aacgaacaca
    10681 tcaaacaaca caaaaaagac cacgctactt accgtggatt gatgaaaaaa atcggtcgcc
    10741 gtcgtaactt gcttgcatac ttgcgtaaaa acgacgttaa ccgttaccgt gagttgatca
    10801 actctctagg acttcgtcgc taattcaaga tacaaaggcc gtcaaaaaca caaagcaaaa
    10861 ataggaaaat tgacgaagaa acttcagttt ctaggagatt ttatcttttt tgccaagtgc
    10921 ttaggccgtg ttcaattgag catatcttga taataaagct actctaaatt gggtagcttt
    10981 gttgcgttgt caccttacct cgctatactc aagtataatc ttcggttacg gttcctagca
    11041 ctgtaaggta aaataaacta gcttttctcc cttcggggag atttttttgt ttcactgaaa
    11101 gtttcgtacg atcttcacct cgtcccctag tctataaacg atttatctag caagaatcat
    11161 gatgctaagg gcgtcaaaaa tccgtatgaa aatagggaaa tgacacagtg ttcgatgagc
    11221 acaaggagtt tcatcttttt cactaggatt ttagcccggg ctaaaatcag ctctctgact
    11281 tcagagggct tttttattga ggttttatcg gtaacaattt tggagactac aaaaacctca
    11341 aatggtatca gctaattaca ccataaaggt gcgcagttac tcggcttttc aagccgagta
    11401 gctgtatgca agccccctag aagagcccac tctttacaaa gtaaagtata gtatgttata
    11461 ctttacatgg aagtagtcac tgaattccag ttagaaatta ctttgtaact acgttttgag
    11521 gaggagtaaa atgctttcct acgttcgaca ttacccacta gcgatagcta aattaatgtg
    11581 tctgtgctct cctaaaatct gctgatttat tactgactaa tacaggaggt tttttttatg
    11641 ggacagacaa tcatatctgc tattggtgtt tatatttcca ccagtatcga ttatttaatt
    11701 attttaatta ttttatttgc acagctatca cagaataaac agaaatggca tatttatgcg
    11761 gggcaatatc taggcacagg cttacttgta ggggcgagtt tagttgctgc ttatgtcgtt
    11821 aatttcgtgc ctgaagaatg gatggttgga ttgcttggtt taatccctat ctatttaggg
    11881 attcgctttg caattgttgg agaagatgcg gaagaagaag aggaagaaat tattgaaaga
    11941 ttagaacaaa gcaaggcaaa tcaactgttt tggacagtta cattgctgac aattgcgtct
    12001 ggcggagata atttaggtat ctatatacct tattttgctt cgttagattg gtcacagacc
    12061 ctcgtggcct tgcttgtgtt tgtaatcggc ataattatct tttgcgagat tagtcgggtg
    12121 ttatcctcta ttccgttaat attcgagaca attgaaaaat acgagcgaat cattgtgccc
    12181 ttagtattca ttctacttgg actatacatc atgtatgaaa atggcacgat agagactttt
    12241 ctgatcgtgt agattttttt gtttcactag gattttagcc cgagctcaaa tcagctctct
    12301 gattttcagg gggctttttc attgagtata aatggacaat cttaaagtta ctctattgta
    12361 gagtggcttt tgatttgatt aggagattct tataaatata gtaaaatgaa ataagaatag
    12421 gacaaatcga tcaggacagt caaatcgatt tctaaaaatg ttttagaagt agaggtgtac
    12481 tattctagtt ccaatctact atataaatga aaaccttagc tgtttggcca aggttcattt
    12541 cttctatgca agttcttctc ttttcttatc tgggttccag atgaagcttg cgataaagct
    12601 aaagatgatg gttaggatag cgaggataat agcaaggatg agggcaggga tgcggataaa
    12661 ccaccagagt ggatttggtt ttttatcatt gtgccattgt ttcgtttctt cgtccagacg
    12721 ttggaattct gtttgaatac gattggcgac tgtttcaatg ccttcatcat tcattttctt
    12781 gatatctgag atatcgattg gatttccaaa gttcatatcg acacgttcac ggctaatcaa
    12841 gcccttcaaa gtcatgggac cggtgtaggt aaccggcatg atacggacct tggccatttt
    12901 ggcaatcagt gctgcgcccc ccttgacatc gtttgagtgg cggctaccac ttggaaacat
    12961 gatgagagag cggtcacttt ttttgagaac gttgatagga tatttgatgg ctgaggcgct
    13021 gggattttca cggtcgatgg gaaaggcgcc acacatacga atccaccaac caaagatacg
    13081 gttggtaaag agttcttttt ttgccataaa gatgaactgt tttggcttgg tcgcaaaggc
    13141 catataaaca ggatcccacc aggtacggtg aggcgcaact aaaatataat tttcatcttg
    13201 attaggaatt ttatcagtat tatgatagtg agcattgcca ttgatggacc ataagagcaa
    13261 tacaactaat ccacgcaaat aagtataaaa catgcgatct ccttcgattg ttttcttgtt
    13321 attattatac cttatcaaag gagggctggc aaacttttcc cttgactaga tacatattta
    13381 ggatgaaatt agaattctgt taaaaaaaat gatataatag aatttatgga taaaaataag
    13441 attatgggat taacccaaag agaagtcaag gaaagacagg ctgagggttt ggtcaatgac
    13501 tttaccgcat cagccagtac cagcacttgg caaatcgtta aacgaaatgt ctttaccctt
    13561 tttaacgctt tgaactttgc cattgctttg gctcttgcct ttgtgcaggc ttggagcaat
    13621 ctggtcttct ttgctgttat ctgctttaac gctttttctg ggattgtgac cgagctacga
    13681 gccaaacaca tggtggacaa gctcaatctc atgaccaagg aaaaggtcaa aaccatccgt
    13741 gatggtcagg aagttgctct taatcctgaa gaattagtgc taggagatgt cattcgtttg
    13801 tctgcaggag agcagattcc tagtgatgcc ttggttttgg aaggctttgc ggaagtcaat
    13861 gaagccatgt taacgggaga aagtgatttg gtgcaaaagg aagttgacgg cttacttttg
    13921 tcaggaagtt tcctagccag tgggtcagtt ttatctcaag ttcaccatgt cggtgcagac
    13981 aactatgctg ccaaactcat gcttgaggct aagaccgtta aacccatcaa ctcccgtatc
    14041 atgaaatcgc tggacaagtt ggctggtttt actgggaaga ttatcattcc ctttggtctg
    14101 gctctcttgc tggaagcctt gcttttaaaa ggcctgcctc tcaagtcatc cgttgtaaac
    14161 tcgtcgacag ctcttttggg aatgttgcct aagggaattg cccttttgac cattacttcg
    14221 ctcttgactg cagtgattaa gttgggcttg aaaaaggtct tggtgcagga gatgtactct
    14281 gttgagacct tggcgcgcgt ggatatgctc tgtctggaca agacgggtac catcacccaa
    14341 ggaaagatgc aggtggaggc tgttcttccg ttgatggaaa cgtatggtga agaggctatt
    14401 gccagcatct tgactagcta catggcccat agtgaggata agaatccaac tgcccaagcc
    14461 attcgccagc gttttgtggg agatgttgct tatcctatga tttccaatct tcccttctcg
    14521 agcgaccgca agtggggggc tatggagtta gaaggcttgg ggacagtttt cttaggggcg
    14581 cctgagatgt tgctggattc tgaagtccca gaagccaggg aggccttgga gagaggatca
    14641 cgtgtcttgg tcttagctct cagtcaggag aaattagacc atcacaaacc acagaaacca
    14701 tctgatattc aggctctagc cttgctggaa atcttggact ccattcgaga gggagcagca
    14761 gagacgctgg actatctccg ttctcaggag gtaggactca agattatctc tggtgacaat
    14821 ccagttacgg tgtccagcat tgcccagaag gctggttttg cggactatca caactatgta
    14881 gattgctcaa aaatcaccga tgaggaattg atggccatgg cggaggagac agctattttc
    14941 ggacgtgttt cccctcatca aaagaaactc atcatccaaa cgttgaaaaa agcgggtcat
    15001 acaacggcta tgacagggga cggggttaat gatatcttgg cccttcgtga ggcggattgt
    15061 tctatcgtga tggcggaggg ggatccagca acccgtcaga ttgccaatct ggttctcttg
    15121 aactcagact ttaatgatgt tcctgagatt ctcttcgagg gtcgtcgcgt ggtcaataac
    15181 attgcccaca tcgccccgat tttcttgata aagaccatct actcattctt gctcgcagtt
    15241 atctgtatcg ccagtgcttt actaggtcgg tctgaatgga tcttgatttt ccccttcatt
    15301 ccaatccaga ttaccatgat tgaccagttt gtggaaggtt tcccaccatt cgttctgact
    15361 tttgagcgaa atatcaaacc tgttgagcag aatttcctca gaaaatccat gcttcgtgcc
    15421 ctaccaagcg ctctcatggt cgtctttagc gtcctgtttg tgaaaatatt tgggagtagc
    15481 caaggttggt ctgagttaga aatctcaact ctcctctatt atctcttggg gtcaattggt
    15541 ttcttatccg tatttagagc ctgcatgcca tttaccctat ggcgtgtcct cttgattgtt
    15601 tggtcagtag gaggtttcct agccacagct ctcttcccaa gaatccaaaa actgcttgaa
    15661 atttcaacct taacaggaca aacattacct gtttatggtg tcatgatgtt ggtctttacc
    15721 gtgattttca tcctgaccag tcgctatcaa gccagaaaat aaagaaaggc tgcaatctgt
    15781 ggattgcagt ttttttaggt acaagattgc cagtcgaaat gtggtataat aagaggtaat
    15841 agagttttgg aaagtgagag aagatgattt caaagagatt agaattggta gcttcctttg
    15901 tgtcacaggg ggctatttta ctagatgtgg gaagtgacca tgcttatctg cctatcgagt
    15961 tggtcgaaag aggacaaatc aaaagtgcca ttgcaggtga ggtggtggaa ggtccctacc
    16021 aatctgcggt caaaaatgtt gaggcgcacg gcctaaagga gaaaatccaa gtccgtttag
    16081 ccaatggctt ggcagctttt gaagaagcag accaagtgtc tgtcattacc attgctggca
    16141 tgggtggtcg tttgattgct aggattttag aagaaggttt ggggaagtta gctaatgtag
    16201 agcgtttgat cctccagccc aataatcgtg aagacgactt gcgtatctgg ctacaggatc
    16261 atggattcca gattgtagca gaaagcatct tagaagaagc tggaaagttt tatgagtttc
    16321 tagtagtgga agttggagaa atggaattat cagcaagaga tacccggttt ggccccttct
    16381 tgtcaaggga aatcagccca gtatttgtcc aaaaatggca aaaagaagct gagaagctag
    16441 agtttgccct cggacaaatc ccagaaaaaa atctggaaga acgtcaagtt ctagtagata
    16501 agattcaagc catcaaggag gttctccatg ctagcaagtg aagtgattaa acgctatgaa
    16561 gccttttgcc ctcaggaatt ttctatggaa ggagacagcc gtggcctgca aattggcact
    16621 ttagacaagg gtatccaaag ggtcatggtg gctctcgata ttcgtgaaga aacggtgact
    16681 gaagccattg aaaagggtgt agacttgatt atcgtcaagc acgcgcctat ctttcgtccc
    16741 atcaaggact tggttgccag ccgtccgcaa aatcagattt atatcgacct aatcaagcat
    16801 gacattgcag tgtatgtcag ccataccaac attgacatcg ttgaaaatgg tctcaatgac
    16861 tggttttgtc agatgctagg cattgaggag acgacttatc tacaggagac aggtcctgaa
    16921 cgtggaattg gacgtattgg gaatgttcag tctcagacat tttgggaatt gacccaacag
    16981 gtcaagcaag tctttggcct agatagcctt cgaatggtgc attatcaaga gaatgactta
    17041 cagaagccta tttcaagagt ggctatctgc ggtggtagtg ggcagtcttt ctataaggat
    17101 gctttagcta aaggagcgga agtctatatc actggtgaca tctactacca cactgcccag
    17161 gatatgctgt ctgatggctt gctagcattg gatccaggac actatatcga agtgctgttt
    17221 gtggaaaaaa tcgcagagct tcttactcaa tggaaagaga aaaaaggctg ggaactagag
    17281 attttaccta gtcaagcatc gaccaatcct ttccgtcata tctagttaga aagtgaagac
    17341 aatgaaaaaa gttgccatta ttggagcagg aattgtggga gcaacagctg cctactacct
    17401 ctcgagagaa agtgacctag aggtgaccgt ttttgaccat gagcaaggtc aagccaccaa
    17461 ggccgcagca ggaattatca gtccttggtt ttccaaacgc cgtaataaag cctggtacaa
    17521 gatggcgcgc ttgggggctg atttttatgt ggatttatta gctgatttag agaaatcagg
    17581 acaagaaatc gacttttacc agcgttcggg agtctttctc ttgaaaaagg atgaatccaa
    17641 tttggaagaa ctttatcaac tggccctcca acgcagagaa gaatctccct tgatagggca
    17701 attagccatt ctgaaccaag cctcagctaa tgaattattc cctggtttgc agggatttga
    17761 ccgcctgctc tatgcttctg gtggagcgag agtagatggc caacttttag tgactcgttt
    17821 gctggaagtc agtcatgtca agctggtcaa agaaaaagtg actctgacac cgttagcatc
    17881 aggctaccag attggtgaag aggagtttga gcaggttatt ttggcgacgg gagcttggtt
    17941 gggggacatg ttagagcctt taggttatga agtggatgtc cgtcctcaaa aaggacaact
    18001 acgagattat cagcttgccc aagacatgga agattaccct gttgtcatgc cagaagggga
    18061 gtgggatttg attccctttg caggtgggaa attatcctta ggcgctaccc acgaaaatga
    18121 catgggattt gatttgacgg tagatgaaac cttgctccaa caaatggagg aggccacctt
    18181 gactcactat ctgattttgg ctgaagctac ttcaaaatct gagcgtgttg gaatccgtgc
    18241 ctacaccagt gatttctctc ctttctttgg gcaggtgcct gacttaactg gtgtctatgc
    18301 agccagtgga ctaggttcat caggcctcac aactggtcct attattggtt accatttagc
    18361 tcaactgatc caagacaagg agttgacctt ggaccctgaa aactacccaa ttgaaaacta
    18421 tgtcaaacga gtaaaaagcg aataatactc aatgaaaatc aaagaacaaa ctaggtaact
    18481 agccgcgggt tactcaaagc actgctttga ggttgtggat agaactgacg aagtcagctc
    18541 aaaacactgt tttgaggttg tagatagaac tgacgaagtc agtaaccata cccatggcaa
    18601 ggcgacgttg acgtggtttg aattggattt tcgaagagta taagcatttt actgaaattt
    18661 tatcaggtag tttaggatgg caaatgacat tccctgtcaa aaatggtaaa ataagaaaaa
    18721 ataatctgag aatcgaggaa aaaagatgca agaaaagatt ttggtaactg gtggtgccgg
    18781 ttttattgga acccacactg ttattgaatt gatccaagca ggccatcaag ttgttgtggt
    18841 ggataatctt gtcaatagca atcgtaagag tttagaagtt gttgaaagaa tcacaggagt
    18901 tgagattcct ttctatgagg cagatattcg tgacacagtt accctcagag atattttcaa
    18961 gcaggaagaa ccgactggtg tcattcactt tgctggtttg aaggctgttg gcgaatcaac
    19021 acgtatccct cttgcctact atgacaacaa tatcgctgga actgtcagcc ttttgaaagc
    19081 catggaagaa aacaactgta aaaacatcat cttcagttct tctgcgacag tttacgggga
    19141 tccgcacaca gtgcccatct tggaagattt cccactttca gtgaccaacc catacggtcg
    19201 tactaagctc atgctagagg aaattttgac tgatatttac aaagcagact cagaatggaa
    19261 tgttgtcttg cttcgttact ttaacccaat cggagcccat gagagtggtg atttgggaga
    19321 aaatccaaac ggtattccaa acaatctctt gccatatgtg actcaagtag ccgttggaaa
    19381 attagagcaa gtgcaagtgt ttggagacga ttacgatacg gaagatggaa caggtgttcg
    19441 tgactatatc cacgttgtcg atttggctaa gggtcacgtt gcagctttga aaaaaatcca
    19501 aaaaggttca ggactaaacg tttataacct tggaactggt aaaggttact cagttcttga
    19561 aattatccaa aacatggaaa aagcggtggg acgtcctatt ccttaccgca tcgtagaacg
    19621 tcgctcaggt gatatcgctg cctgctactc agacccggca aaagctaaag cagaactcgg
    19681 ttgggaagca gaactcgaca tcacccaaat gtgtgaagac gcatggcgtt ggcaaagcaa
    19741 gcatccaaat ggatttgaag actaagatga tgatttcaat catcgtccct tgtttaaacg
    19801 aagaggaagt acttcctctt ttttatcagg ctctggaagc tttacttcca gatttggaaa
    19861 cagaaatcga gtatgtcttt gtcgatgatg gatcaagtga tgggaccttg gaactcttaa
    19921 aggcctatcg ggagcaaaat ccggcagtcc attatatttc tttctctcga aattttggca
    19981 aagaagcagc cctttatgca ggcttgcaat atgcgacagg agatttggtg gtggtgatgg
    20041 atgcagacct ccaagatcct cctagtatgt tgtttgagat gaaaaatgta ctagacaaaa
    20101 atgtagactt ggactgcgtt gggacacgga gaactagtcg ggagggagaa cccttctttc
    20161 gcagtttctg tgctgttctc ttttatcgcc tcatgcaaaa aatcagccca gtagctctgc
    20221 cgtcgggtgt ccgtgacttt cgtatgatga gaaggtctgt ggtcgatgcc attttaagct
    20281 tgactgagtc caatcgtttt tctaagggac tctttgcctg ggtcggcttt aaaacccact
    20341 atctggacta tccaaatgtc gaaaggcagg ctggcaagac cagttggagt tttaggcaac
    20401 tcttttttta ctccattgaa gggattgtta atttttcaga tttccctttg actatagcct
    20461 ttgtagctgg tctcctatct tgttttcttt ctctgctgat gacctttttt gttgtggttc
    20521 ggaccctcat tttgggcaat ccgacatctg gttggacctc tctgatggct gttattctct
    20581 ttcttggagg cattcaactc ttgaccattg ggattctcgg taagtatatc agtaagattt
    20641 atttagagac taaaaaaaga ccactttatc ttatcaaaga aaaaagtgac cttcctgatt
    20701 ttacagaaaa aataaagtga aaagactata attttacatg gaaatgtgct aaactagagg
    20761 gagtggatta tcgccattga tttaggcttc ctggtttcca atcagggcgc gagttgggca
    20821 atttttaaca gcctctaaga catcctgact aggagaaatt tctttttcca gttggtcagg
    20881 gtcatcgtaa aaacgcacga ttccattatc gtggtaatca aataaatcag aataagtttg
    20941 gcaaagtcca caggcgatac atcgttcagg tataagtgtg attttcatgt tcatatttat
    21001 attgtaataa gaaaagtaaa aaaaaacaag gagtaaggta tggcaaaaga accgtggcaa
    21061 gaagatattt atgatcaaga agaatcaaga gcagggcgtc ggcatcgaaa ccacggaggg
    21121 gctgatagga tggctaatcg tattttgacg atcctagcta gtattttctt tgtaattgtg
    21181 gtggtgatgg tcatcgttct catctatcta tcatcggggg ggagtaatcg cacagcagcc
    21241 ttaaaagact ttcatgattc tgatgcaagt gtagtacaaa tctcatcttc aagcagttct
    21301 cagcctgagc agagttcaga gccagaatct acttctagta gttcagaaga agctgctaat
    21361 cctgaaggaa cgattaaagt tctcgcagga gaaggggaag cagctattgc cgctcgtgca
    21421 ggaatctcca ttgctcagtt agaggccttg aatcctgggc acatggctac aggatcttgg
    21481 tttgctaatc caggtgatgt tataaaaata aaataggagc cgatatgaaa acaattcaaa
    21541 ttgctattga tggtcctgct tccagcggta agagtacggt cgcaaagatt attgctaagg
    21601 attttggatt cacctacctt gatacaggag ctatgtatcg tgcagcgacc tatatggctc
    21661 ttaagaacca attaggagtt gaagaagtcg aagcccttct agccttgttg gaccagcatc
    21721 caatcagctt tggacgttca gaaactggag accagcttgt ttttgtagga gatgtggata
    21781 ttacccatcc tatccgtgaa aatgaagtga ccaatcatgt ttctgctatt gcagcaattc
    21841 ctgaagtgcg tgagaaactg gtttctctcc aacaagaaat tgcccagcaa ggcgggattg
    21901 tcatggatgg tcgcgatatt ggaactgttg tattgccaca agcagaattg aaaattttcc
    21961 tagtagcttc tgttgatgag agagcagagc gtcgttacaa ggaaaatatt gccaagggaa
    22021 ttgaaacaga ccttgaaacc ctaaaaaagg aaattgctgc gcgtgactac aaggatagtc
    22081 atcgtgagac ttctcctctc aaacaagcag aggatgctgt ctaccttgat acaactggtt
    22141 tgaacattca agaagtagtt gaaaaaatca aagcagaagc tgaaaaaaga atgtaaatgt
    22201 agaaaagccg atagattgat atcggttttt tctaaatttg tcaaaatgct gattttaggg
    22261 tataatagtt gctgttcgag aaattttgat tttcaaagaa tagtgaatga tgataaggag
    22321 aaatcatgaa caatttacca aattgtccaa aatgtaactc agagtatgtc tacgaagacg
    22381 gtgccctact ggtttgccca gagtgtgctc atgagtggaa tcctgctgaa gttgcagaag
    22441 tagaagaagg tcttgtcgct atcgatgcca acggaaataa attggctgat ggtgatacag
    22501 taactctcat caaggacttg aaagtaaaag gtgcgccaaa agatttgaaa caagggacgc
    22561 gcgtgaaaaa tatccgcatc gtagaaggcg accacaatat cgactgtaag attgatggtt
    22621 ttggtgccat gaaacttaaa tcagagtttg tgaggaagat ttaagcatgt caaaacacta
    22681 taaacttgta ttttatagcc gtatcttctt gtttctagcg gcttttacgg gagtttatct
    22741 tgaaattact aagcatggtg gttttgggat gcttctctat tacacggttc tgtccaacct
    22801 cttggtaact atttttaccc tttatcttct aaaggttatg agccgtgtag gtgaaaattg
    22861 gcaaagacca agtctcttgc gcttaaaagg tggggtcacc atgagtatca tgattacctg
    22921 tgtgatttac catttcctct tggcgcccat tgcgactaat ttctataccc tagaaaattt
    22981 cctttgccac tatatcgttc ccatctggtt tttagcggat accctctttt ttgacaaaca
    23041 gggtcaatac aagatttggg atccagcagt gtggaccatt ttaccctttc tgtatatgat
    23101 gtttgctctt tttaatggct tggttctaaa actcaatatt ccaaatgcca aggataatcc
    23161 tttcccttac ttctttttga atgtgaacaa gggttggaat gttgtgttta agtggtgtct
    23221 gattatcttt gttgcctata tggtagcagg atttattttc tactttatca agcaaatcaa
    23281 gagaaagtca tcctaatact cttcgaaaat ctcttcaaac cacgtcagtt tccatctgca
    23341 acctcaaaac actgttttga acaacctgcg gctagcttcc tagtttgctc tttgattttc
    23401 attgagtata agatacaagg gattcatttt cgaatttaag aaggagtcta caaaccaatg
    23461 aggcttcttc ttttcttgct tatttgataa ctatcaaaaa agtagaagat taagagaaat
    23521 atagaaagag atttcatgaa acaattttta gaacgggcca gcattttggc tctctccctc
    23581 gttttgatta cctccttttc catttcgagt gccctaccag ccatgtttga ctattatcag
    23641 ggttattcta aggaacaaat tgagctcttg gtgagcttgc cttcctttgg aatcatgatg
    23701 atgttactgc taaatggttt cttagaaaaa atatttcctg agcgcttaca gattagtttg
    23761 ggcttgctga ttttatcatt gagcggtaca gctcccttct ggtaccaagc ctatcccttt
    23821 gtctttggaa cacggcttct ctttggtttg ggtcttggga tgatcaatgc caaggccatt
    23881 tctattatca gtgaacgcta ccaaggaaaa aggcgaattc agatgttagg gctacgcgct
    23941 tctgcagagg tcgttggagc ttctctcatt accttggccg tcggtcagtt gttggccttt
    24001 ggttggacag ctatctttct agcctatagt gctggatttt tggtgctgcc cctttatctg
    24061 ctctttgtcc cttatggaaa atcaaagaaa gaagtcaaga aaagagcgaa ggaagcaagt
    24121 cgtttaactc gagaaatgaa aggcttgatt tttaccttag ctatcgaagc ggcagttgta
    24181 gtttgtacca atacagctat taccatccgt attccaagtt tgatggtgga aagaggattg
    24241 ggggatgccc agttatctag ttttgttctt agtatcatgc agttgatcgg gattgtggct
    24301 ggggtgagtt tttctttctt gatttctatc tttaaagaga aactgctcct ctggtctggt
    24361 attacctttg gcttggggca aatcgtgatt gccttgtctt catccttgtg ggtggtagta
    24421 gcaggaagtg ttctggctgg atttgcctat agtgtagtct tgacgacggt ctttcaactt
    24481 gtctctgaac gaattccagc taaactcctc aatcaagcaa cttcatttgc tgtattaggc
    24541 tgtagtttcg gagcctttac gaccccattc gttctaggtg caattggctt actaactcac
    24601 aatgggatgt tggtctttag tatcttagga ggttggttga ttgtaatctc tatctttgtc
    24661 atgtacctac ttcagaagag agcttaggat tgattcctaa gtttttcttt tgatactcaa
    24721 tgaaaatcaa agagcaaact atagttgatt gagtttggaa tagtacgctg tagctgctaa
    24781 aatatttcta gaaattaatt tgactttcct aatagagttg ttcatatctt atttcaatct
    24841 actatagaaa gctagccgca ggttgctcaa aatagtgttt tgaggttgca gatggaaact
    24901 gacgtggttt gaagagattt tcgaagagta tgagattttt atacccatac aatatttgtt
    24961 ttaggtcctt gtttacagac taatttcttg ataaaataga ggctatgacg agatataaag
    25021 caactatttc ctatgatggt tatgcctttg ctggctttca gcgccagcct catgcgcgta
    25081 gcgttcagga agaaattgaa aaaaccttga ccagattaaa taaagggcaa gccattactg
    25141 ttcacggtgc tggtaggaca gatagtgggg ttcatgccct gggacaggtc attcattttg
    25201 acctgcctta tcagatggat gaggagaaac tccgttttgc cttggatacc cagtctcctg
    25261 aagatattga tgtgatttcg attgagcttg tggcagatga ttttcattgc cgttatgcca
    25321 aacatagcaa gacctatgag tttattttgg atagaggacg tcccaaaaat cctatgcgcc
    25381 gtcactatgc cacccacttt ccctacccac tcgatgtgga acgaatgcag attgcaatca
    25441 aaaagctaga gggaacccat gattttaccg gttttacagc ctctgggact agtgtagagg
    25501 ataaggttcg caccatcaca gaagctagtt taatagtcga tgagacagga caatttttga
    25561 cctttacctt ttcaggaaat ggtttcttgt ataaacagat tcgcaatatg gtggggactc
    25621 ttctcaaaat cggtaacaac cgcatgccag tagagcagat tgatctcatc ttggagaaga
    25681 aggacaggca acttgcaggt cccactgcag caccaaatgg tttgtattta aaggagattc
    25741 gttatgaaga ataatcgtat tttagcactt tctggaaatg atatttttag tggtggtgga
    25801 ctgtcagctg atttggctac ctataccttg aacggcttgc atgggtttgt agcagtgact
    25861 tgtttgacag ccttgacaga aaaaggattt gaagtctttc caactgatga taccattttt
    25921 caacatgaat tagatagctt gcgtgatgtg gaatttgggg gaattaagat tggtcttctc
    25981 cctactgtca gtgtggctga gaaggccttg gactttatca aacaacgccc aggagtacct
    26041 gtggtgttgg atcctgtctt ggtctgcaag gaaacgcatg atgtagctgt cagtgagctc
    26101 tgccaagagt tgattcgctt tttcccttat gtcagtgtga ttacgcctaa tctctcagaa
    26161 gcagaattat tatccggtca ggaaattaaa accttggaag acatgaaaac tgcagcgcag
    26221 aaattgcatg atttaggagc gccagcagtc attatcaagg gaggcaatcg tcttagtcag
    26281 gacaaggctg tggatgtctt ttatgatgga cagaccttta ctatcctaga aaatccagtt
    26341 atccaaggcc aaaatgctgg tgcaggttgt acctttgcct ctagcattgc cagtcacttg
    26401 attaaaggtg ataaactttt gccagcagta gaaagctcta aggctttcgt ttatcgtgct
    26461 attgcacaag cagatcagta tggagtaaga caatatgaag caaacaaaaa caactaaaat
    26521 cgcccttgta tccctattaa ccgccctttc tgtggttcta ggttatttct taaaaatccc
    26581 aacacctaca ggaattctaa ctcttttaga tgctggtgtc ttctttgcgg ccttttactt
    26641 tggtagtcgt gaaggagcgg tagtcggagg actagcaagt ttcttgattg acctcttatc
    26701 aggctaccct cagtggatgt tctttagctt ggtcaaccat ggcttgcagg gatttttcgc
    26761 aggatttaaa ggaaaaagtc agtggttagg ccttatttta gcaactattg ccatggtagg
    26821 aggctacgcc ttgggttcta ctttgatgaa tggctgggca gcagccctcc cagaaattct
    26881 accaaatttc atgcaaaata tggtagggat gattgtagga tttattctta gtcaaagtat
    26941 caagaagatt aagtaatact cttcgaaaat ctcttcaaac cacgtcagct tccatctgca
    27001 acctcaaaac actgttttga gcagcctgag gctagcgttc tagtttgcac tttgattttc
    27061 attgagtata aagaggttga gtaaaaagta tttcaaataa gaaaaacgca tagtatcagg
    27121 tgttgaatga actgcccccc aaaagttaga cagaaaaaat ctaacttttg gggtgttttt
    27181 attatgaaat taagttatga tgataaagtt cagatctatg aacttagaaa acaaggatat
    27241 agcttagaga agctttcaaa taaatttggg ataaataatt ctaatcttag gtatatgatt
    27301 aaattagttg atcgttacgg aatagagttc gtcaaaaaag ggaaaaatcg ttactattct
    27361 cctgatttaa aacaagaaat gattaataaa gtcttacatg aaggctggac taaagataaa
    27421 gtttctcttg aatacggcct cccaagtcgt acgatacttc ttaactggct agcacaatac
    27481 aggaaaaacg ggtatactat tgttgagaaa acaagaggga gagcacctga gagcggagaa
    27541 tgccatccta aaaaagttaa gagaactccg attgaaggag gaaaaagaga aagaagaaag
    27601 acagaaattg ttcaagaatt aatgactgag ttttcgttag atcttcttct aaaagccatt
    27661 aaactagctc gttggaccta ctactattac ttgaaacagc tagacaaaac agataaggac
    27721 caagagctta aagctgaaat tcaatccatt tttatcgaac acaagggaaa ttatggttat
    27781 cgtcggattt atttagaact aagaaatcgt gcttatctgg taaatcataa aagagttcaa
    27841 ggcttgatga aagtactcaa tttacaagct aaaatgcgac agaaacgaaa atattcttct
    27901 cataaaggag acgttggcaa gaaggcagag aatctcattc aaggccaatt tgaaggctct
    27961 aaaacaatgg aaaagtgcta cacagatgtg actgaatttg ccattccagc aagtactcaa
    28021 aagctttact tatcaccagt tttagatggc tttaatagcg aaattatcgc ctataatctt
    28081 tcaacttcac ccaacttaga acaagtacaa acaatgttgg aacaggcatt cacagagaag
    28141 cactacgaga atacgattct ccatagtgac caaggctggc aatatcaaca cgattcttat
    28201 catcggttcc tagagagtaa gggaattcaa gcatctatgt cacgcaaggg aaacagccaa
    28261 gacaacggta tgatggaatc tttctttggc attttaaaat ccgaaatgtt ttatagctat
    28321 gagaaaacat ttaaatcact taatcaattg gaacaagcca ttgtagacta tattgattat
    28381 tacaacaata agagaattaa ggtaaaacta aaaggactta gccctgtgca atacagaact
    28441 aaatccttcg gataaattat ttgtctaact tttgggggtc agtacattca acacctgata
    28501 ctatgcgttt tattgtggga agattttcct cattttctag tgaaattgaa ctttttctaa
    28561 catcttttga tagatgactt cttaatcaat tctcatttcc attgttgttt cttggggttt
    28621 catcccttgt ctttgataaa agcggagagc accctcgtta tcattccaga cacttagggt
    28681 tagattactg cagccaattt ctttagcata atagcagaaa aatgacaata aaatagcccc
    28741 tagatatttt gaaaggaaag cataggggct atatagttta atcaaaataa agcaaatctt
    28801 tgctggtgct tgtaaagagg tcgaagccat ccttggtaac aacaccgcag tcttcaatac
    28861 gaacaccgac tttaccaggg atatagatac ctggttcaac agagaagcac atgccttctt
    28921 cgatgaccat gtcgtttcct tccatgatag atgggaattc atggacatcc ataccgatac
    28981 catgcccgag acggtggttg aagtactcac cataaccagc tttttcgatg acctcacggg
    29041 cagcgcggtc cacttcatga gcagtcacac ctggcttgat aaagtcaaga gcagcttgtt
    29101 gggcttcaag agtcaagttg taaatatctt tcttgaattg gtctggtttg ccgacagcga
    29161 ctgtacgagt catatctgac gcatagccat tgaccagaac acccaggtca aagaggagaa
    29221 gagcatcatt ttcaacctta ttagctgctg gaatgccgtg tggattcgca gcattatcac
    29281 cagtcaagac catggtatca aagctcattt cgtaaccttc acgtttcatg gcaaagtcaa
    29341 tttgtgcgat gatatctgtc tcagtcttat caagagaaat attgtcaaaa ccaacatgaa
    29401 cagccttgtc agcataaaga cctgcaacca tcattttttg cacttcatca gctgatttga
    29461 tgaggcgcat gcgttggata cgaggagtga ggttgtcaaa ctcagcagtc tcaaaaactg
    29521 ttttcaaacc atggtatttg gtcaagatga gattgtcaaa ctcaacagcg acacgtttga
    29581 agtcaagttg tggaagagca tgtttgattt tttgccatgg attttcagaa tcgacatagc
    29641 ccactactgg gaaggaaacg gtgctacttg cacgttctac ttcaagagct gggacaaaga
    29701 ggagaggttc ctgatctgct aggacaaaga ggaacatttg gcgttcatgg ggatcactgt
    29761 aaaaaccagt gaggtaattg attgtgacgg ggtcagatac gacagcgacg tctagttttt
    29821 ctgattcaag atatgttagg atttgttgta atttagacat atgctacctt ctttctaccc
    29881 ctctattttg gcaaaaaatg agagaaaatg caagggagaa gggtaaaaga aaagacaaaa
    29941 aactccgaca agataacgga gttctttgat atcattttcc tttgtttaag aaaagtcagc
    30001 cttgcttttg acgtcactgt actcttcagc gatttcttgg ctgagaatgt cctcataggc
    30061 agggagttgg atgtcctgac catatttctt cttgagggca gtagtaacta ggcgataagc
    30121 cagattggca ttacgagaga ggataggccc gtggaagtag gaaccaaaga cattcttata
    30181 atgaacccct tcaccgacct tttcttcgtt gtttccattt ccatagacaa cctgtcccag
    30241 cggtttttgg tcatcagaga ggaaggtacg accttggtga ttttcaaatc catagtaggt
    30301 ttcatcgaaa tcttcattgt gaatcttgat gtcaccgata aaacggttat tggtctggtt
    30361 gagcgtgtag tgtcccatga cccctagccc ttcgatacgt tttcctgaag cttcaacata
    30421 atattgaccc aatagttgga aaccaccgca gatagccaga actacaccgt cgttttggat
    30481 gtagttgtca atgctctctt ttttagcagg taggtcgtct gcaatgatac tttgttcaaa
    30541 gtcttgacca ccaccgaaaa aggcgatgtc gtagtgattt gcatcaaagt catcatggag
    30601 agaaacgatg tcaacgatca catgggctcc cagtttttca gccacatact tgagcatgag
    30661 gatgtttcca ttgtccccgt aggtattcat gagatttccg tagaggtggg caatgttgag
    30721 ctgatagggg taattgccat cttttgagga aagtgaagta taaaccatta gttcatctcc
    30781 tttctaacaa tctgacgact agccagcagt tcacgaaatt ccagcatggc agtataagtt
    30841 gccagaatat aggcatgctt gcagtcttga ttctcaatgg tcttgagaac ttgctccaga
    30901 ttactcgttt cagtgatttt ctcagctgga tagccagtca ctcggaggcg acgagcgatt
    30961 tcagaatgac gaacaccgcc agcgttgatt tcaggaatgt ccatgtcagt gatttgttca
    31021 aagtctgcat cccagatcca gctagtgtca attccatctg catagttggc attaaggagg
    31081 acagataggc taaatggata aggtgctagt ttgatcattt cgatagcttg ggttgcaccg
    31141 actggatttt taatcaagac aagggtacat tccttgtcac cgatatgaaa ggtttcttgg
    31201 cgtccaaaga cagcacggct cttgtcaaat ccctgtttga tgagttgcaa atcggcacct
    31261 aggaaacggg cgatggccac agcagctagg gcgttataga tattatagag cccgccgatt
    31321 tggataccgt attcttggcc gtctatgaca aagcgagagc gattgttggt caactcaacc
    31381 agttttgtca aacgatagtc gagatcagga cgtttacatc cacaaccttc acagatatag
    31441 gcacccaagt ttgcataggt attatgctca tatttgagga tgccttggca gtcaggacag
    31501 agaatccctt cggtattgta gtgagccagt tgggctggtc ccttttccaa gtcaaaacca
    31561 aaatactcta tagggtttgg aatagttggc ttgtagaaaa gtggactgtc tccgttaagg
    31621 agaacagtag cagttggaac tttccgaatg gcatccaata tcatgttata ggtagtatag
    31681 atttcaccga aacggtccat ctggtcacgg aagatattag taatgacaaa aagactaggc
    31741 tggatatagt cacagatacg agatagactg gcttcgtcaa tttcgaggac ggcaatattt
    31801 ttcccagttt tagaagattt ggctgttagg aaggttgttg caatccctgt aatcatgttg
    31861 gcaccgcttg ggttggttag aacttgacca taaacctctt ttaaaatgcc gacagtgagg
    31921 gcagttgtca gggtttttcc atttgttcca gtgacaacga caatctcgta gttcttagct
    31981 aggttttgta aaatatcttt atcaaattga agggcgactt tccctgggag cgtacttcca
    32041 cgtccaagac ggcttaaaac gaagtgggaa gaacgcccag caagaaggcc caaagtagtt
    32101 tttaagttca tgtttctatt atatcacaaa agtatatcac aaaagaggga aaagacagat
    32161 ttggtgtttc gtagaagtaa aaacagccca aagagggctg tcagttaaga tgagatttca
    32221 acttaaatcg caaacaagtc attcaagttc tcagccaagg ttgggtgagt gaagatttgt
    32281 tttgtgaagt aagtgtaagg aatcttgttg tccatagcaa cagtaataat gttgatgatt
    32341 tcttgagaac cttctgagaa gatgcttgca ccaagaattt cttttgtttc tgtattaaca
    32401 acagctttga aagctccgcg aaggtctcca tttacgtgac cacgaggcat ggctgcaaca
    32461 gggatttctt tcactgcgta tggaagtttc aaatcagctg cttggctttc agtcaaacca
    32521 acttgtgaaa gtgcaggtgt gatgaacata gtatttggca cattgagacg gtcctcaagt
    32581 gtgtagctgc catctccagc aaggtagctg taaacaacac ggaagtcatc aagtgaaatg
    32641 taagtaaatt gaagaccacc gttgacatct ccaactgcaa agacaccagg aacgtttgtt
    32701 tgacagtgtt tatctacttt aatagcgcca cgttcagtta gttcaatatc tgtattttca
    32761 agttgaagtg gttctacatt tggtttgcgt ccagttgcgt agagaagggc gtcgaaacgg
    32821 taagtttcgt cttcagttac gacaagcact tggtcaccgt cgtttttaat ttcagtagta
    32881 tggatatttt gaagcaattc aataccgtct tcttccatgt attgtttagc aagagctgcg
    32941 atggaaggtt ctgcacgagg taggaatgta tccaaggcat ctaggactgt aaccttgctt
    33001 cctagtttat tgtaaaggcc agcaaattca agaccgatat ttccgccacc aaggactcca
    33061 agtttttcag gcaatttatc caagctttgg atacctgttg agtcaaagac gtttttgctt
    33121 gtagcaagtc cagggattgg caagacgttt gaaacagcac cagtgttgat gacgatagtt
    33181 tcagcagtca attcttgttt ttcatcacca gcttggattt cgatgacttt atttgaaagg
    33241 aagtgagctt cagcatcaaa gatatcgacg ccagtaccag caacagtcgt atagttttta
    33301 ccgttgaggc gaccagtgat cgtgtttttg gtagcaatga cttcttcaaa agacaagtct
    33361 ttctcagcag caaccagcaa agttttagtt gggatacaac cgatgttgat acaagttcca
    33421 ccgtacatag ctttgctacg ttcaacgagg gcaacttttt tgccagctga agccaattta
    33481 ccagctagtg ttttaccagc tttaccaaat ccgataacga ttaaatcata agttaacatt
    33541 tagaattcct cctattcgaa ttacattcta gcacaagaaa aaaacttttg cacaattctg
    33601 ctacgaaaaa gacagaaaaa tatgaaaacg atttccaggc aaaaaactag taattttttg
    33661 acaagcttga taaactaaaa tcctatctat ttttatataa gatagaataa atgttcgaaa
    33721 ataggaggtt ttatgaaatc gaatcgttat attattgcct ttgctggggt cattttacac
    33781 ttaatgctgg gttcgactta tgcctggagt gtttatcgta accctattat tgaaaaaacg
    33841 ggatgggatc aggcttctgt tgccttcgcc tttagtctag caatcttttg tttgggctta
    33901 tcggctgcat ttatggggcg tttggtagaa aaatttggtc cgagagtcat ggggagtcta
    33961 tctgcttttc tatacgcagg tggaaatatc ttaacaggat ttgcaataga ccgtcaggaa
    34021 ctgtggttgt tgtatctagc ttatggcatt ttaggtgggc ttggtttggg agcaggctat
    34081 attacccctg tgtcaacgat tataaaatgg tttcctgata aacgtggtct cgcaacaggt
    34141 ttagcgatta tggggtttgg ttttgcttct ttattgacta gtcccatagc gcaacatctc
    34201 atcgcagggg tagggcttgt agaaactttt tatattttag gtgcaagtta ctttattatc
    34261 atgctcctag cttcacaatt cattaagcgt ccaaatgagc aagagcttgc aattttatct
    34321 gcttcaggga aagaaaaaac agactctctg acgcaaggga tgactgcaaa tcaggctcta
    34381 aaaagcaatc ggttttatat actttggatt attttcttta tcaacatagc ttgtggttta
    34441 ggcttaattt cagcggcatc gccaatggca caggagatgg ctggcttgtc tacaagtcat
    34501 gcagcagtaa tggtgggcgt tttagggatt ttcaatggat ttggtcgctt gctctgggcg
    34561 agcttatctg actatatcgg tcgccctcta acctttagta tattactgct tgttaatctt
    34621 ttcttttctc tctcactttg gctctttaca gattccgttt tatttgtagt cgctatgtct
    34681 attttgatga cttgctatgg agctggtttt tcattgatcc cagcttatct cagtgatatt
    34741 tttggaacca aggaattggc cgctctgcat ggttatattt taacagcttg ggcaatggct
    34801 ggtttagcgg gacctatttt attagcagag acttataaaa tggctcattc gtatacacaa
    34861 accttgttcg tttttctcat tttatacagt atcgccttgg ctttgtctta ttatctaggt
    34921 cgttcaatca aaaaagaaag tcaaaaaccg cttacatgat tttctgtaga aatggggcta
    34981 tcttttgctc tggtcttgtg ttatactaga taggttgcaa agaaaacagt acttttcttt
    35041 tgtggaaaag aagcaacacg attttatatc tagttatatg aaaatacgtc ataaaaagaa
    35101 aagtataaac taagccctat agggtggctt cgcaccacct ttagaaagaa gaataacgtg
    35161 aaatttaatg aattaaactt gtctgctgat ttgctagcag aaattgaaaa agctggtttt
    35221 gtagaagcta gtcctatcca agaacaaact attcctttgg cccttgaagg caaggatgtt
    35281 atcggtcaag ctcagactgg tacaggaaaa actgcagcct ttggcttgcc tacccttgaa
    35341 aaaatccgta cagaagaagc gactatccaa gccttggtca tcgctccaac tcgtgaacta
    35401 gctgtccaaa gtcaagaaga actcttccgc tttggtcgta gtaagggagt caaagtccgt
    35461 tcagtatatg gcggatcaag cattgaaaaa caaattaagg ctcttaaatc tggtgcccat
    35521 atcgtggtgg gaactccagg tcgcctcttg gacttgatta aacgcaaggc cttgaaatta
    35581 caagacattg aatcccttat cctcgacgaa gcggatgaaa tgcttaacat gggcttcctt
    35641 gaagacatcg aagccattat ttcccgtgta cctgagaacc gtcaaacttt gcttttctca
    35701 gcaactatgc cagatgccat caaacgtatc ggtgttcagt ttatgaaagc ccctgaacat
    35761 gtcaagattg cggctaagga attgacaaca gaattggttg accagtacta tatccgtgtt
    35821 aaggaacaag aaaaatttga caccatgact cgtctcatgg atgtggcaca accagaactc
    35881 gctattgtat ttggtcgtac caaacgccgt gtggatgaat tgactcgtgg tttgaaaatt
    35941 cgtggcttcc gtgcagaagg aattcatggc gacctagacc aaaacaaacg tcttcgtgtc
    36001 cttcgtgact ttaaaaatgg caatcttgat gttttggttg cgacagacgt tgcagcgcgt
    36061 ggtttggata tttcaggtgt gacccatgtc tacaactacg atattccaca agatcctgag
    36121 agttatgttc accgtatcgg tcgtacaggt cgtgctggta agtcaggtca atctattact
    36181 tttgttgctc caaacgaaat gggttacctt caaatcattg aaaacttgac taagaaacgc
    36241 atgaaaggtc tcaaacctgc aagtgtagaa gaatccttcc aatcaaaaaa acaggtagct
    36301 ctcaagaaaa tcgaacgtga ttttgcagat gaaaccattc gtgccaactt tgagaaattt
    36361 ggtaaggatg ctcgcaaatt ggctgctgag tttactccag aagaattggc aatgtatatc
    36421 ttgagtctga cagtccaaga cccagatagc cttccagaag tggagattgc acgtgaaaaa
    36481 ccactaccgt ttaaaccatc aggtaatggt ttcggtggta aagctaaggg aggtcgtgga
    36541 ggccgtcgtg gggacgaccg tcgagagcgt gatcgtcgtg gcaatggtcg ccgtgatgag
    36601 ttcaaaaaag gaagtcgtgg caacgatcgt tttgataagg aaaaacgtta ccgtaaggat
    36661 aataaaaaac cacgcaatac tttaagcgaa aagcaaacag gctttgttat tcgtaacaaa
    36721 ggtgataaat aagaaaaagc ggttcaaaat gaatcgcttt tttatataag gagaccgaat
    36781 gtgaaaaaga caaataaaat tattatatta tcttttataa tattatgata cacaaaaata
    36841 ggcgacttgt caatagaaaa ggaacaattt aattaaaaat attctggttt ttaattaaat
    36901 tgtaagtcaa tgcaagtcaa taaggaattt tcagataatt attgaaaaag agacgttttt
    36961 atgttataat gatagcgatt aaattcgagg tgaaaaatgg cacatttatt agaaaaaact
    37021 agaaaaatta catcaatttt gaaacgctca gaggagcagt tgcaggatga gctcccttac
    37081 aacgctatta cgcgtcagtt agcggatatt attcattgca atgcctgcat tatcaatagt
    37141 aagggacgtc tgcttggcta ttttatgcgt tataaaacaa atacagatcg cgtagagcaa
    37201 ttcttccaaa ctaagatttt cccagatgac tacgttcaag gggctaatat gatttacgaa
    37261 acagaagcaa acttgcctgt tgagcatgat atgagtattt tccctgttga gagtagagat
    37321 gattttccag atggcttgac gactattgca ccgattcatg tatcggggat tcgccttggt
    37381 tctttgatta tttggcgtaa tgataaaaaa ttcgaagatg aggacttggt tcttgttgag
    37441 attgccagta ccgttgttgg gattcagctt cttaacttcc aacgtgaaga agatgagaaa
    37501 aatattcgtc gtcgtactgc tgtcaccatg gcggtcaata ccctttctta ctccgaactc
    37561 cgtgctgttt cagcaatttt aggggaatta aatggaaatg aagggaagtt gactgcgtca
    37621 gtgattgcag atcgtatcgg aatcactcgc tctgtgattg tcaatgctct tcgtaaactt
    37681 gagtctgcgg ggattattga aagtcgctca cttggaatga agggaaccta tcttaaggtc
    37741 ttgatttcag atatttttga agaagtgaag aaaagagatt actaatgaca aaggctttaa
    37801 tttcgattga ttatacagaa gattttgttg ctgatagtgg gaagctgaca gcaggtgctc
    37861 cagctcaggc gatttcggat gccatcagca aggtaactcg attagctttt gaacgaggag
    37921 attatatctt ctttactatt gatgctcatg aagaaaacga ttgtttccat ccggaaagta
    37981 agttatttcc tcctcataat ctgattggga cgagtggacg gaatttatat ggagatttgg
    38041 ggatctttta tcaagagcat ggttcagaca gtcgtgtctt ttggatggat aaacgccatt
    38101 actcagcttt ttcagggact gacctagata ttcgtttgag agagcgtaga gtgtctaccg
    38161 ttatcttaac aggtgtcttg acggatatct gtgtcctaca tacagctata gatgcctata
    38221 atctaggata tgacatcgag attgttaaac cagctgttgc ttccatctgg cctgaaaatc
    38281 atcaatttgc cctaggtcat ttcaaaaata cactcggagc taagttagta gatgaaaatc
    38341 taaatgaact ttctgagtaa cctggttggt gaaaatgaaa aaatttgaaa aaaagtgttg
    38401 acaagcatcc caaaagttga tatactagta aagtaatcga tgcggggatg gcggaattgg
    38461 cagacgcgca ggactaagga tcctgtgacc gctttaggtc gtgagggttc aagtccctct
    38521 ctccgcatag gaaaagagtt agctaaagct agctcttttg tatttctcta aaaaattaga
    38581 atccagtcaa atgtagtgga gaatcagcga aaatatggga aaactgatcc ttgtttctgc
    38641 ttttgtcata gaagaataat aaagattatc ttcttcaaat tctccgatat tctctaaagt
    38701 tttgtgcaag ttgcacagaa cttttttatt tttttggtca tcttgccata gaaatataaa
    38761 gcgttttcat ctataatata attatcaaaa gacaaaagga gttcacctca tggtagaatt
    38821 gaatcttaaa aatatttaca aaaaatatcc aaacagcgaa cactattcag ttgaagattt
    38881 caacttgaac atcaaagata aagaatttat cgttttcgta ggaccttcag gatgtggtaa
    38941 atcaactaca ctccgtatga ttgctggtct tgaagacatc acagaaggta ctgcatctat
    39001 cgatggcgtg gttgtcaacg acgtagctcc aaaagaccgt gatatcgcca tggtattcca
    39061 aaactacgct ctttacccac acatgactgt ttatgacaac atggctttcg gtttgaaatt
    39121 gcgtaaatac agcaaagaag acattaacaa acgtgttcaa gaagcagctg aaatacttgg
    39181 attgaaagaa ttcttggaac gtaaaccggc tgacctttca ggtggtcaac gtcaacgtgt
    39241 tgccatgggg cgtgcgattg tccgtgatgc gaaagtattc ttgatggacg aacctttgtc
    39301 aaacttggat gccaaacttc gtgtatcaat gcgtgctgaa atcgctaaaa ttcaccgtcg
    39361 tatcggagct acaactatct atgtaactca cgaccaaaca gaagcgatga cacttgcaga
    39421 ccgtatcgtt attatgtcag ctactaagaa ccctgctggt acaggtacta tcggacgtgt
    39481 agaacaaatc ggtactcctc aagaagttta caaaaatcca gttaacaaat tcgttgcagg
    39541 attcatcgga agcccagcta tgaacttcat caacgtgaaa ttggttggta gcgaaattgt
    39601 ttctgacggt ttccgtttga aagtgccaga aggagcattg aaagttcttc gtgaaaaagg
    39661 ctacgaagga aaagaattga tctttggtat ccgtccagaa gacgtgaatg cagaacctgc
    39721 tttccttgaa acattcccag actgtgttgt aaaagcgact atctctgtat cagaactgct
    39781 tggttcagaa tctcaccttt actgccaagt tggtaaagac gagtttgttg caaaagttga
    39841 tgctcgtgac tacttgcaaa caggtgcaac agttgagctt ggatttgact tgaacaaagc
    39901 acacttcttc gatgtagaaa ctgaaaaaac aatctactaa gaataaataa aattcaaagc
    39961 actacaagaa aagatatctc tttatcaatt gtagtggaga gatatcagtt aatctaggga
    40021 gagaaacaaa atgcttctct cctttttgct agggaagtca tattatacat ctatattgtg
    40081 atgctcttta tactcttcga aaatctcttc aaaccacgtc aacgtcgcct tgccgtacgt
    40141 atgattactg acttcgtcag ttttatctgc aacctcaaag ctgtactttg agtagcttac
    40201 ggctagtttc ctagtttgct ctttgatttc cattgagtat tatttgtggg taccatctac
    40261 aagtgaagct atatgcgtaa actacgtgag caattgaatt cgaactagag aggtaataat
    40321 aaatttatgc tatagttatg gtgacttgta tgcttttgat tctagtttat caaataatag
    40381 attagaattg tcagataata tcattttgtg ttataatgaa gaaaaaacag aggtgttcaa
    40441 atgtcagaag caggtcataa gtttttagca aaattgggga aaaaacgctt acgtccaggt
    40501 ggaaagcgtg ccacagattg gttaattgca gaaggaggat tttcaaaaga aaagagaata
    40561 ctagaggttg cgtgtaatag gggaactaca gcaattgagt tggcacagcg ttttggttgc
    40621 aagataactg ctattgatat ggatgctcaa gctttagaag tggctaaaaa atctgctgga
    40681 acggcaggtg ttgctcattt aatcagtttt gaaagagcaa atgcaatgaa acttccttat
    40741 caagatgcta gttttgatat tgttataaat gaagctatgc tgactatgca agccgatcaa
    40801 gctaagaaaa aatgtgtaat ggaatatcta agggtattaa aacctggagg tcttctcttg
    40861 acacatgatg tgcttcttaa ggaagctaaa gagtctatca gacaggaatt atcacaagca
    40921 attcatgtaa atgtaggtcc tttaactcaa gatggttggg aacaggtgat gatagaatca
    40981 ggttattgtg atgtgaaagc attgactggt gaaatgacat taatgaaatt atcgggtatg
    41041 atttatgacg aaggtttgct aggaactttg aaaatttgtg taaatgcttg taaaaaggag
    41101 aatagaaagc agtttttaac tatgtataaa atgtttgcta agaataaaca gaaattgggc
    41161 tttattgcga tggctagtta taaatcgtca aaacgttaga taattattga agttaacttt
    41221 tccttttttc tttcttaaaa aatatgctat aatagagagt aaaaaacttt gaaagaaaga
    41281 aaaagatgaa tttaaaagat tacattgcaa caattgaaaa ttatccaaag gaaggcatta
    41341 ccttccgtga tattagtcct ttgatggctg atggaaatgc ttatagctac gctgttcgtg
    41401 aaatcgttca gtatgctact gacaagaaag tcgacatgat cgtgggacct gaagctcgtg
    41461 gatttatcgt gggttgtcca gttgcctttg agttgggaat tggttttgcg cctgttcgta
    41521 agccaggtaa attgccacgc gaagttattt ctgctgacta tgaaaaagag tacggtgtcg
    41581 ataccttgac tatgcacgcg gatgccatta agccaggtca acgtgttctt attgtagatg
    41641 accttttggc gacaggtgga actgttaagg caactatcga gatgattgaa aaacttggtg
    41701 gtgttatggc aggttgtgcc ttccttgttg aattggatga attgaacggc cgtgaaaaaa
    41761 ttggtgacta cgactacaaa gttcttatgc attattaatg aaaacagtcc ctagggctgt
    41821 tttctctaca ctaggatata aaaatagact ataactagtt agagaaaaac tataattgaa
    41881 aactatatct tcttacagta taataaaagg actaagtgtt tgagatttgt cttcaaacat
    41941 atgcaattat tcctgaaaga gtacagttag gagagggtta tgccgattcg aattgataaa
    42001 aaattgccag ctgttgagat tttacggaca gagaatatct ttgtcatgga tgatcaacgt
    42061 gctgcccacc aagatatccg tcctttgaag attttaattt taaatctcat gccacagaaa
    42121 atggtcacag agacccagtt gttgcgccac ttggctaata cacccctaca actggatatt
    42181 gattttctct atatggagag ccaccgttct aaaacaactc gttcagagca catggagacc
    42241 ttctataaaa cttttcctga agtcaaggat gagtattttg atgggatgat catcacgggt
    42301 gctccagttg agcatttacc atttgaggaa gtggactatt gggaggaatt tagacagatg
    42361 cttgagtggt ctaagactca tgtctattcg acccttcata tctgttgggg ggctcaggct
    42421 gggctttatc tgcgctatgg tgtagaaaaa taccagatgg acagtaagct atcaggtatt
    42481 tatcctcagg acaccctaaa agagggtcac cttctattta gaggctttga tgatagctat
    42541 gtatcccctc attcacggca cacggagatt tctaaggaag aggtcttaaa caagaccaat
    42601 ctcgagattt tatcagaagg acctcaggtt ggggtttcta ttttggccag tcgtgattta
    42661 cgagaaattt atagttttgg tcatttggag tatgaccgtg ataccttggc aaaagagtat
    42721 tttcgagatc gtgatgcagg tttcgaccca catattccag aaaattactt taaagatgat
    42781 gatgttaatc aggtaccttg tctttgttgg tcttcatctg cagccctctt tttcagtaat
    42841 tggataaacc atgcggtcta tcaggagacg ccttttgatt ggagaaagat agaagatgat
    42901 gcatctgcat atgggtattt ataagaggaa ttatgacata tttagacgct tttaaatcag
    42961 gtatcttggt tttaccgagt gccctgctct tgcattttaa ggaactcttt ccttctagcg
    43021 acgattttct ggtttggcaa tttttctatt tgcaaaatac gacaggctta gaagaaatgt
    43081 cgccaagcca gattgctgaa aggattggca aggaaatttc ggatgtcaac cagtccattt
    43141 ctaatctgac ggaaagggga ctgctccagt atcgtactat cgaattaaat ggcgaaattg
    43201 aattgctctt tgatgctagt ttggccttgg aacgtttgga tgacctgttt ggagcagttc
    43261 attcaagttc agaccagctg acacctcaaa accagctcaa ggatttggtg gaaaccttcc
    43321 agcaggagtt gggacgattg ttgacgcctt ttgagattga ggatttgacc aagacactaa
    43381 aggaagatgg aaccagtgct gacttgatta aggaggctct tcgtgaagct gttttgaatg
    43441 gaaaaccaaa ctggaagtac attcaggcga ttttgagaaa ctggcgccat gaaggaatca
    43501 agagtgtggc tcaaattgag gccaagagag cagaaagaga agcaagcaat cctcagttga
    43561 cacaggtatc tgcagatttc agaaatgcca tggatctctg gaaggattaa tccatgcaag
    43621 caggcttgaa atccgagtaa gatttgcaag ctgtgtataa ttgtgataga ataaaataga
    43681 aaataaattg aaaaaagagg tatgtgaaat gtcacgtaaa ccatttatcg ctggtaactg
    43741 gaaaatgaac aaaaatccag aagaagctaa agcattcgtt gaagcagttg catcaaaact
    43801 tccttcatca gatcttgttg aagcaggtat cgctgctcca gctcttgatt tgacaactgt
    43861 tcttgctgtt gcaaaaggct caaaccttaa agttgctgct caaaactgct actttgaaaa
    43921 tgcaggtgct ttcactggtg aaactagccc acaagttttg aaagaaatcg gtactgacta
    43981 cgttgttatc ggtcactcag aacgccgtga ctacttccat gaaactgatg aagatatcaa
    44041 caaaaaagca aaagcaatct ttgcgaacgg tatgcttcca atcatctgtt gtggtgaatc
    44101 acttgaaact tacgaagctg gtaaagctgc tgaattcgta ggtgctcaag tatctgctgc
    44161 attggctgga ttgactgctg aacaagttgc tgcctcagtt atcgcttatg agccaatctg
    44221 ggctatcggt actggtaaat cagcttcaca agacgatgca caaaaaatgt gtaaagttgt
    44281 tcgtgacgtt gtagctgctg actttggtca agaagtcgca gacaaagttc gtgttcaata
    44341 cggtggttct gttaaacctg aaaatgttgc ttcatacatg gcttgcccag acgttgacgg
    44401 tgcccttgta ggtggtgcgt cacttgaagc tgaaagcttc ttggctttgc ttgactttgt
    44461 aaaataatca gtaagtagca aaagctaggt ggaacagcat tcagatgtct gttacatttt
    44521 ttataggaga ggaaagattg aaaataaaaa ttggattagc aagtatctgt ttactaggct
    44581 tggcaactag tcatgtcgct gcaaatgaaa ctgaagtagc aaaaacttcg caggatacaa
    44641 cgacagcttc aagtagttca gagcaaaatc agtcttctaa taaaacgcaa acgagcgcag
    44701 aagtacagac taatgctgct gcccactggg atggggatta ttatgtaaag gatgatggtt
    44761 ctaaagctca aagtgaatgg atttttgaca actactataa ggcttggttt tatattaatt
    44821 cagatggtcg ttactcgcag aatgaatggc atggaaatta ctacctgaaa tcaggtggat
    44881 atatggccca aaacgagtgg atctatgaca gtaattacaa gagttggttt tatctcaagt
    44941 cagatggggt ttatgctcat caagaatggc aattgattgg aaataagtgg tactacttca
    45001 agaagtgggg ttacatggct aaaagccaat ggcaaggaag ttatttcttg aatggtcaag
    45061 gagctatgat gcaaaatgaa tggctctatg atccagccta ttctgcttat ttttatctaa
    45121 aatccgatgg aacttatgct aaccaagagt ggcaaaaagt gggcggcaaa tggtactatt
    45181 tcaagaagtg gggctatatg gctcggaatg agtggcaagg caactactat ttgactggaa
    45241 gtggtgctat ggcgactgac gaagtgatta tggatggtgc tcgctatatc tttgcggcct
    45301 ctggtgagct caaagaaaag aaagatttga atgtcggctg ggttcacaga gatggtaaac
    45361 gctatttctt taataataga gaagaacaag tgggaaccga acatgctaag aaaatcattg
    45421 atattagtga gcacaatggt cgtatcaatg attggaaaaa ggttattgat gagaacgagg
    45481 tggatggtgt cattgttcgt ctaggttata gcggtaaaga agacaaggaa ttggcgcata
    45541 acattaagga gttaaaccgt ctgggaattc cttatggtgt ctatctctat acctatgctg
    45601 aaaatgagac cgatgctgag aatgacgcta aacagaccat tgaacttata aagaaataca
    45661 atatgaacct gtcttaccct atctattatg atgttgagaa ctgggaatat gtaaataaga
    45721 gcaagagagc tccaagtgat acagatactt gggttaaaat catcaacaag tacatggaca
    45781 cgatgaagca ggcgggttat caaaatgtgt atgtctatag ctatcgtagt ttattacaga
    45841 cgcgtttaaa acacccagat attttaaaac atgtaaactg ggtagcggcc tatacgaatg
    45901 ctttagaatg ggaaaaccct tattattcag gagaaaaagg ttggcaatat acctcttctg
    45961 aatacatgaa aggaatccaa gggcgcgtag atgtcagcgt ttggtattaa gcaatgattt
    46021 gaaagaggga tgtgatagta gcaccctctt tttctttgtt ttatgatagt tcatcctcga
    46081 gtaaattcaa gatcttgctc ggaaatgaag cttatatagt agattgaata tagacaaata
    46141 ccttgtgatt ggtaaaacat tttagaaatt catttacctt tcctaatcga cttggtttca
    46201 tcttatttca atctattata gtattgggga atttcttcaa accacatcag cttggtcagt
    46261 tctacctgcg acctcaaaac ttgtgctttg gtcaagctgg gtttagtttc ctagtttgct
    46321 gatggatttc cattgactat aagcatccaa acctcttttt tgtcttctaa agaattctta
    46381 aattatcagt ctattgcaac ttttctcata taagttcttt gtcttgctat tggttttcct
    46441 tagtagtata ctaaggtagt aatcattaag aagtggttac aaaaaataat gaatgaggta
    46501 aagaaaatgg tagaattgaa aaaagaagca gtaaaagacg taacatcatt gacaaaagca
    46561 gcgccagtag cattggcaaa aacaaaggaa gtcttgaacc aagctgttgc tgatttgtat
    46621 gtagctcacg ttgctttgca ccaagtgcac tggtatatgc atggtcgtgg tttccttgta
    46681 tggcatccaa aaatggatga gtacatggaa gctcttgatg gtcatttaga tgaaatcagc
    46741 gaacgcttga tcacacttgg tggaagccca ttctctactt tgacagagtt ccttcaaaac
    46801 agtgaaatcg aagaagaagc tggtgaatac cgtaatgttg aagaaagctt ggaacgtgtt
    46861 ctagctattt atcgctacct catcactctt ttccaaaaag cgttggatgt gactgacgaa
    46921 gaaggcgatg atgttacaaa cgatattttt gttggtgcta aggctgaact tgagaaaaca
    46981 gtttgggtgc ttgccgcaga acttggacaa gcacctggtt tgtaagaaac aagacaacat
    47041 agataaatct gtaggaaatt tcttacagat tttttctatt ttgtaagcta ttccaaacca
    47101 gtcttttttt gagttttttg ataaaatagt actatcagta aaaaggatgg aagcatgact
    47161 aagaaaatcg tagctatttg ggcccaggat gaagatggtg tgattggtaa ggacaatcgt
    47221 ctgccttggc atttaccagc agaattgcaa cactttaaag aaacaactct gaatcatgct
    47281 atcttgatgg ggcgtgtgac ctttgatgga atgggacgtc gtctgcttcc aaaacgggag
    47341 accttgattt tgacacgtaa ttcggaagaa aagctagacg gagttgctac ttttcatgat
    47401 gtccagtctg tcttggactg gtatcatgct caagacaaga atctctatat tcttggtggg
    47461 aagcaaattt ttcaggcttt tgaaccctac cttgatgaag tgattgtgac tcacattcat
    47521 gctcgggtgg agggagatac ctatttccct gaagagtttg acttgtccct ttttgagacg
    47581 gtttcaagca aatcttatac caaagatgag aaaaatcctt atgattttac catccaatac
    47641 cgcaagagaa aggaagtcta atggaacgga gtttatttgg tttattcacg gcttttctgt
    47701 gtttcatctg ccttttggca ggagcacagg cttttcgtaa aaagcgttac gggctttcta
    47761 tcctcctttg gttaaatgcc tttaccaatc tggtcaatag tattcatgct ttttacatga
    47821 ccttatttta gatagaatga cagtatagaa tggaaggaaa tcatgtctac aaatagaaaa
    47881 aatgatatga tggtttattg ctcattttgt ggcaaaagcc aagaagaagt acaaaaaata
    47941 atcgctggca acaatgcctt tatttgtaat gaatgcgtgg agctagctca agaaattatt
    48001 cgagaagaat tggttgagga agtcttggca gacttgtctg aggtaccaaa accaatcgaa
    48061 ctcctccata tcttgaacca ctatgtaatc ggtcaagatc gtgccaagcg tgccttggca
    48121 gtggcggttt ataatcatta caaacgcatc aatttccacg atacacgcga agagtcagaa
    48181 gatgtggatt tgcagaagtc aaacatcttg atgattggcc caactggttc agggaaaact
    48241 ttccttgctc agaccttggc taagagcttg aatgtacctt ttgcgattgc ggatgcgaca
    48301 gctctgacgg aggctggtta tgtaggtgag gatgtggaaa atatcctcct caaactcttg
    48361 caggctgctg actttaacat tgagcgtgca gaacgtggga ttatctacgt ggatgaaatt
    48421 gacaagattg ctaaaaagag cgagaatgta tcgatcacac gtgatgtttc tggtgaaggg
    48481 gtgcaacaag ccctcctcaa gattatcgag ggaaccgtcg caagcgtacc tcctcaaggt
    48541 ggtcgcaagc atccacaaca agagatgatt caagtggata ctaaaaatat cctctttatc
    48601 gtgggtggtg cctttgatgg cattgaagaa atcgtcaaac aacgtcttgg agaaaaagtc
    48661 atcggatttg gtcaaaataa caaggcgatt gatgaaaaca gctcttacat gcaagaaatc
    48721 atcgcagagg atattcaaaa atttggtatt atccctgagt taattggacg cttgcctgtt
    48781 tttgctgctc ttgagcaatt gacggtcgat gacttggttc gcatcttgaa agagccaaga
    48841 aatgccttgg tcaaacagta ccaaaccttg ctttcttatg atgatgtcga gttggaattt
    48901 gacgacgaag ccctacaaga gattgctaat aaagccatcg aacggaagac aggggcgcgt
    48961 ggacttcgct ctattatcga agaaacaatg ctagatgtca tgtttgaagt accgagtcag
    49021 gaaaatgtga aattggtccg catcactaaa gaagctgttg atggaacgga taaaccaatc
    49081 ctagaaacag cctagaggtg actatggaac tgaatacaca caatgctgaa atcttgctca
    49141 gtgcggctaa taagtcccac tatccgcagg atgaactgcc agagatcgct cttgcagggc
    49201 gttcaaatgt tggcaagtct agctttatca ataccatgct gaaccgtaag aatctggctc
    49261 gtacgtcagg gaaacccggg aaaacccagc ttctcaactt ctttaacatt gacgacaaga
    49321 tgcgctttgt agatgtgcct ggttatggtt atgcccgtgt ttccaaaaag gaacgtgaaa
    49381 agtgggggcg catgattgag gagtacctaa cgactcggga aaatctccgt gcggtagtca
    49441 gtttagttga ccttcgtcat gacccgtcag cagatgatgt acagatgtac gaatttctca
    49501 agtattatga gattccggtt attatcgttg cgaccaaggc ggacaagatt cctcgtggta
    49561 aatggaacaa gcacgaatca gcaatcaaaa agaaattaaa ctttgaccca agtgacgact
    49621 ttatcctctt ttcatctgtc agcaaggcag ggatggatga ggcttgggat gcaatcttag
    49681 aaaaattgtg aggaaaagaa aatggcaaaa acaattcata cagacaaggc cccaaaggct
    49741 atcggaccct atgttcaagg aaaaatcgtt ggcaaccttt tgtttgctag cggtcaagtt
    49801 cccctatccc ctgaaactgg ggaaattgta ggagagaata tccaagaaca gacagagcaa
    49861 gtcttgaaaa acatcggtgc tattttggca gaagcaggaa cagactttga ccatgttgtc
    49921 aaaacaactt gcttcttgag cgatatgaac gactttgttc cttttaatga ggtttaccaa
    49981 acggccttca aagaggaatt cccagctcgt tcagctgtgg aggtagctcg tcttcctcgt
    50041 gatgtaaaag tcgaaattga agtcatcgca gagattggat aagctagttg aagtttggtg
    50101 ttgccaaact tcttttgata taaggagaaa aagatgacaa agaaacaact tcacttggtg
    50161 attgtgacag ggatgagtgg cgcagggaaa actgtagcca ttcagtcctt cgaggatcta
    50221 ggttatttca ccattgataa tatgccgcca gctctcttgc ctaagttttt gcagctggtt
    50281 gaaattaagg aagacaatcc taagttggcc ttggtagtgg atatgcgtag ccgttctttc
    50341 ttttcagaga ttcaagctgt tttggatgag ttggaaaatc aagatggttt ggatttcaaa
    50401 atcctctttt tggatgcggc tgataaggaa ttggtcgctc gttacaagga aaccagacgg
    50461 agtcacccac tagcagcaga cggtcgtatt ttagatggaa tcaagttgga acgtgaactc
    50521 ttggcacctt tgaaaaatat gagccaaaat gtggtggata cgactgaact cactccacgt
    50581 gagctgcgta aaacccttgc agagcagttt tcagaccaag aacaagccca gtctttccgt
    50641 atcgaagtca tgtctttcgg atttaaatat ggaatcccga ttgatgcgga cttggtcttt
    50701 gatgtccgtt tcttgccaaa tccctattat ctaccagaac tgagaaacca aacgggtgtg
    50761 gatgaacctg tttatgatta tgtcatgaac catcctgagt cagaagactt ttatcaacat
    50821 ttattggcct tgattgagcc gattctgcca agttaccaaa aggaaggtaa gtccgttttg
    50881 accattgcta tgggatgtac gggtggacaa caccgtagtg tggcatttgc taaacgcttg
    50941 gtgcaggact tatccaagaa ttggtctgtt aatgaagggc atcgcgacaa agaccgcaga
    51001 aaggaaacgg taaaccgttc atgagaaaac caaagataac ggtgattggt ggagggactg
    51061 gaattcccgt cattctaaaa agtctgcggg aaaaagatgt ggaaatcgca gctatcgtga
    51121 cggtggcaga tgatggtggt tcttcaggtg aactccgaaa aaatatgcaa cagttgacac
    51181 cgccaggtga tcttcgtaat gtccttgtgg ccatgtcgga tatgcctaag ttttatgaga
    51241 aggtctttca gtatcggttc tctgaggatg ccggagcctt tgctggccat ccattgggaa
    51301 atctcatcat tgctggcttg tcagaaatgc agggttcaac ctataatgcc atgcagttat
    51361 tgagcaaatt tttccataca acagggaaaa tttatccttc cagtgaccat cctttgaccc
    51421 ttcatgcagt ctttcaggat gggacagaag tggctggaga gagtcatatt gtagaccatc
    51481 gaggcataat tgacaatgtc tatgtgacca atgccctaaa cgatgatacg cctctggcca
    51541 gccgtcgagt agtgcagacc atccttgaaa gtgacatgat tgtcctaggg ccaggttccc
    51601 tctttacctc tattttgccc aatatcgtga ttaaggaaat tgggcgggct cttttggaaa
    51661 ctaaggcaga aattgcctat gtctgcaata tcatgaccca acgtggggag acggaacact
    51721 ttacagatag cgaccacgtg gaagtcttgc atcgtcacct tggtcgccct tttatcgaca
    51781 ctgtcttggt gaatattgaa aaagtgcctc aggaatacat gaattccaac cgttttgatg
    51841 aatacttagt gcaagtggaa cacgattttg taggtctttg taagcaagtt tcgcgcgtga
    51901 tttcatctaa cttccttcgt ctggaaaatg gcggtgcctt ccacgatgga gatttgattg
    51961 tggacgagtt gatgcgcatt atacaggtga aaaaatgagt ttcacagtag cagtaaaaga
    52021 agaaatcctg ggccaacacc atctgagccg gcatgaatta tctgccatta tcaaaatgtc
    52081 tggtagcatc ggtctctcga cttcgggctt gactttgtca gttgtgacag aaaatgccaa
    52141 actggcccgt cacctctatg agtcctttct ccatttctat gaaatcaaat ctgaaattcg
    52201 tcaccaccaa cggagcaatc ttcgcaagaa tcgcgtctat accgttttta cagatgaaaa
    52261 ggtgcaggat ttgttaagtg atttgcactt ggcagactct ttctttggcc tggaaacagg
    52321 tattgatgag gcgattttat cggacgagga agcaggtcgt gcctatctct gtggcgcttt
    52381 cttggcaaat gggagcattc gtgaccctga gtcaggcaag taccagttgg aaatcagttc
    52441 tgtttatctg gaccacgcgc aaggaattgc ctcccttctc caacagtttt tactggatgc
    52501 caaggtgctt gagcgcaaga agggggctgt gacctatctc cagcgagcag aagacattat
    52561 ggacttcttg atagtaatag gagccatgca ggcacgtgat gattttgagc gggttaagat
    52621 tttgcgagaa acccgtaacg acctcaatcg ggctaataat gccgagacag ctaatatcgc
    52681 tcggacagtt tctgccagca tgaagaccat taacaatatc agtaaaatca aagatatcat
    52741 gggcttagaa aatttgccag tagatttgca ggaagtggcg caactgagga ttcagcaccc
    52801 agactactct atccagcagt tagcagatag tctcagcacc cctctgacca aaagtggtgt
    52861 caatcacaga ctcagaaaaa tcaataagat agcggatgaa ttataaaacc acgaatccta
    52921 tgtgactcgt ggttcttttt tataaactgg tagagtgttt tggttgtact ttttgttcag
    52981 ggtcaatgta gttgatagcg ttgttgacag cagttggagc ttctccgagg cctgtcgcaa
    53041 tcagatcaat ttttccgtca tagtagcagc agtcaccgat agcatagata cctgcttggc
    53101 tggattcctg tttgctgttg acgataatct tgtgacggtt gaggtcgagc ccccagtttt
    53161 taaggttacc gacagaagat ttgaaaccat agttgacaaa gaggtggtct aggtcaatgg
    53221 tttcagtttc atcagatttg acttttgtga tttcaagttt atcaagtgtt tttccatttc
    53281 caaggagttg gctaggggcg aatggtgtct tgatggttac agatgattct tgcaaggttt
    53341 gaacactgtg ttccaaggca cggaaattat ctctgcggtg aacaagggta gttggtgcga
    53401 ttttttcaaa agccaaagcc caatccacag ccgagtctcc cccaccaaga atcgtcactt
    53461 tcttaccagc gtattgctga atgttagaaa cgtggtagtg gatattttca tagtcctcaa
    53521 ccccttcaag ttccagcgga cgtggtttga aggcaccgcc acccatagcg atgataactg
    53581 ttttagtcag gtgacttcct ttggaagttg tgatggcaaa ttcttcttct tgtttgtcaa
    53641 tctcaagaac cgtttcattg agatgaatag gggtatcaaa tccatttagc tgttcaatca
    53701 agcggttagt caactcttct ccagtcaggt ttgggaagcc tggtacgtct aggatttcct
    53761 tttcagggta gagaatagca ggttgtccac ctagctgggg aagagagtcg atgatttgaa
    53821 ccttggcttg gcgtaggtgg gcataaaagg ctgcaaaaag cccgacagga ccaccaccca
    53881 caatggtaat atcatagagt tgagacatag tttctccttt gttttttcta gtcagtttat
    53941 tttatcatat ttttgttcaa tgtaaaatgg actaggatag ggaaaaaaat gccagaaaat
    54001 ggtataatag gacgaaagtg ttttgatagg gaggatatca gggatgaatt ttcaacaatt
    54061 atccaatctg caatattgga ccagtttgtt tgcaagtcca tggacgatag ctatcaatct
    54121 gattgatatt ttgattgttg cttatatttt ataccatttt acaaaagcta ttgcaggaac
    54181 caagattatg attttggtac gtggagtttt ggtgtttatt ttagctcaaa tccttgcaaa
    54241 tatgattggt ttgactacga tttcttggtt aatcaatcaa attattactt atggggttat
    54301 tgcggcggtt gttatcttct ctccagagat tcggactggt ttggaacgtt tgggaagagc
    54361 gacagatttc ttttccaatg cccctattag tgctgaggaa cagatgattc gtgcctttgt
    54421 taagtctgtt gaatacatga gtcctcgtaa aatcggggcc ttggttgcta ttcagcgtgt
    54481 acgtaccttg caggagtata tgtcgacagg aattcccttg gatgctaaga tttctgcaga
    54541 acttctcatt aacattttta ttcccaacac tcccctacat gacggtgcgg tgattatcaa
    54601 agaagaacgt atcgctgtga cgtctgccta tctgcccttg acaaaaaaca cagggatttc
    54661 caaggaattt gggaccagac accgggcggc tatcggttta tcagaagtct cagatgcctt
    54721 gacttttgtc gtatcagagg aaacgggagg aatttcgata acctataatg gaaggtttaa
    54781 gcacaaccta acacttgatg aatttgaaac agaattacgt gaaatcttac ttccaaaaga
    54841 ggaagtgggt cttagtttta aagaacgatt gctaggagga tggaaacatg aaaaaaaata
    54901 gtttatatat catatcctca ctcttttttg cttgtgtctt atttgtctat gctacggcga
    54961 cgaattttca aaacagtacc agtgctaggc aggtaaaaac ggaaacctat actaatacag
    55021 taaccaatgt ccctattgac atacgctata atagtgataa gtattttatt agcggttttg
    55081 cttcagaagt atcagtggtc ttgactggtg caaatcgcct atcgctagct agtgaaatgc
    55141 aagaaagtac acgtaaattc aaggttactg ctgacctaac agatgccggt gttggaacga
    55201 ttgaagttcc tttgagcatt gaagatttac ccaatgggct gaccgctgtg gcgactccgc
    55261 aaaaaattac agtcaagatt ggtaagaagg ctcagaagga taaggtaaag attgtaccag
    55321 agattgaccc tagtcaaatt gatagtcggg tacaaattga aaatgtcatg gtgtcagata
    55381 aagaagtgtc gattacgagt gaccaagaga cattggatag aattgataag attatcgctg
    55441 tcttgccaac tagcgaacgc ataacaggta attacagtgg ttcagtacct ttgcaggcaa
    55501 tcgatcgcaa tggtgttgtc ttaccggcag ttatcactcc gtttgataca ataatgaagg
    55561 tgactacaaa accagtagca ccaagttcaa gcacatcaaa ttcaagtaca agcagttcat
    55621 cggagacatc ttcgtcaacg aaagcaacta gttcaaaaac gaattaaaaa tagaaaagga
    55681 ttttataaca atgggtaaat attttgggac tgatggagtc cgtggagaag ctaacctaga
    55741 gctaacacca gaattagcct ttaaactagg acgttttgga ggctatgttc ttagtcaaca
    55801 tgaaacggaa gcgccgaaag tctttgtagg acgtgacaca cgtatttcag gggaaatgct
    55861 ggaatcggcc ttggtggcag gtctcctttc agtagggatt cacgtataca aacttggtgt
    55921 ccttgcaaca ccagcagtag cttacttggt tgaaactgaa ggagcaagtg ccggtgtcat
    55981 gatttctgct agccacaacc cagcccttga taacggaatc aagttctttg gcggtgatgg
    56041 cttcaaacta gatgatgaaa aagaagcaga aattgaagcc ttgctagatg ctgaggaaga
    56101 cactcttcct cgtccaagtg cagaaggctt aggaattttg gtagattatc cagaaggctt
    56161 gcgtaagtat gaaggatacc ttgtttcaac tggaactcct cttgatggaa tgaaggttgc
    56221 cttggataca gctaatggag cagcttctac cagtgcccgt caaatctttg cagaccttgg
    56281 tgcccaattg acggttatcg gggaaacacc agacggtctt aacatcaacc ttaatgttgg
    56341 ttcaacacat ccagaagccc ttcaagaaat ggtcaaagaa agtgggtcag ctattggttt
    56401 ggcctttgat ggagacagtg accgcttgat tgctgttgat gagaatggtg acatcgtcga
    56461 tggtgacaag attatgtaca tcatcggaaa atacctttct gaaaaaggac aattggctca
    56521 aaatacaatt gtgacaactg ttatgtctaa ccttggtttc cacaaggcct tgaatcgcga
    56581 aggtattaac aaggcagtta ctgcagttgg tgaccgctac gttgttgaag aaatgagaaa
    56641 atcaggctac aaccttggtg gtgaacagtc tggtcacgtt atcttgatgg attacaatac
    56701 cacaggtgat ggtcaattat cagcagttca attgactaaa attatgaagg aaactggtaa
    56761 gagcttatca gagttggcgg cagaagtaac gatttatcca caaaaattag ttaatatccg
    56821 agtggaaaac gccatgaagg aaaaggccat ggaagtgcca gctatcaagg ccatcatcga
    56881 gaagatggaa gaagaaatgg cggggaacgg ccgtatcctt gttcgtccaa gtggaacaga
    56941 gcccctcttg cgtgttatgg cagaagcgcc tacaacagaa gaagtggact actatgttga
    57001 tactatcaca gatgtagttc gtgctgaaat tgggattgac taaatcctag aaaactagat
    57061 gaaaataaaa aattatggta caatagctta taatattgta gccgatggag aaagacatga
    57121 atcttaaacg tgaacaagaa tttgttagtc agtatcattt tgatgcgcgt aattttgaat
    57181 gggaaaatga aaatggagct cctgaaacca aggtggatgt gaatttccaa ttgctccaac
    57241 atgaccaaga aaatcaagtg acttccttga ttgtcatctt gagctttatg attgtatttg
    57301 ataagtttgt cattagtgga acaatctcac aagtaaacca tatcgatggc cgtattgtca
    57361 atgaaccaag tgaattgaac caagaagagg tggaaacctt ggctcgtcca tgtttgaaca
    57421 tgctcaatcg tttgacttac gaagtgactg aaattgcatt agacttacca ggaattaatt
    57481 tggagttcta atatgaaatt agctgttttc acagattcct ctgcttatct cagtgaagag
    57541 accttgcaaa gagaagactt gtttgtcttg gatattcctg tcaatattga tggtgaggaa
    57601 tatgtcgaag gcatcaatct gtctgctgag gaattttacc aaaaaatggc tcaggcttct
    57661 gaattgccta agaccagtca accaagtatt gccaagttag atgaaatctt aacttcgctc
    57721 aaagaacaag gctatacaca tgccttgggg cttttcctat cttctggaat ttcaggtttt
    57781 taccaaaata tccagtatat ggtcgatgac tatgagggct taaccattgc tttcccagac
    57841 actttgatta caagtgctcc cctaggcatc atggttgaaa gcgtctttaa ttggcgtgat
    57901 cagggcgatg attttgccag cattcaggat aagctagcca ttcaaatcag ccgtacgtca
    57961 gcctttatca tggtagatga cttggatcat ttggtaaaag gtggacgcct ttcaaatggg
    58021 gctgccattt tgggcaattt gcttagcatt aagccaatcc tttattttaa cgatcaaggt
    58081 gtgattgaag tttacgaaaa agttcgtact gaaaagaagg ccaccaaacg cttaattgaa
    58141 attatcaagg aaacaacggc ttcaggtcaa taccgggtca ttgtcattca tgggaatgct
    58201 cctgaaaagg ctgaagaatt gcgtcagcat ttgcttgatt ttggcttggg ttcggatgtt
    58261 tcacttgcta catttggtag tgtcattgga acgcacctag gagcaggaag tattgctctg
    58321 ggttatattc cagtgattta gttggcactt ctaggctagt taatcttaga aattgaacac
    58381 ggactacctg cctcttgaaa aaagatgcct gtcttgcctt tcgtggaaag tcagtgccat
    58441 tccctatttt tcaggggcag ctaaggtcct ttgtatcttg ataattgaac acgcctggaa
    58501 ccctgtgtga aaaagatagt tcttccaaga agtagacact tcttgattgg aattcctatt
    58561 ttcactttgt gttcttacgg actttgtatc ttagacagga gtagagatga gtattcgagt
    58621 aattattgcc ggttttaagg gaaagatggg ccaggctgct tgtcagatgg tattgactga
    58681 tccagacttg gacttggtgg cagttttgga tccttttgag tctgagtcag aatggcaggg
    58741 tattcctgtt ttcaaggata aggctgattt agctggtttt gaagcggatg tctgggtaga
    58801 ttttactact ccagctgttg cctacgaaaa tacacgtttt gctcttgaaa atggctttgc
    58861 tccagtagtt ggaacgactg gtttcacgag tgaagaaatt gcagagctaa aagaattttc
    58921 tcgtgcccaa gacttgggtg gcctgattgc ccctaacttt gccttgggtg ctgtcttact
    58981 catgcaattt gcgacgcagg ctgccaaata tttcccaaat gtggagatta ttgagctcca
    59041 tcatgacaag aaaaaggatg ctccgagtgg aacagccatt aaaacagctg agttgatggc
    59101 agaggttcga gagtccattc agcaaggtgc agcagatgag gaagagctga ttgctggtgc
    59161 tcgtggtgct gactttgatg gtatgcgcat ccactcagtt cgtttgccag gcttggtagc
    59221 tcatcaggaa gtcatctttg gcaatcaggg agaagggttg accctccgtc atgactccta
    59281 tgatcgcatc tccttcatga caggagtcaa tttgggaatt aaagaagttg tcaagcgtca
    59341 tgagcttgtc tatggattag aacacttatt atgagattaa tgcaaatgcc ttctgaattt
    59401 cagaaggctt taccagtatt agaaaaaatt aaagaagcag gctttgaggc ttattttgtt
    59461 gggggctctg ttcgagatgc ccttctccat agccctatcc acgatgtgga tattgcgacg
    59521 tcttcttatc cagaagagac caagcagatt tttccgcgaa cagccgatat cggaatcgag
    59581 catggaaccg tcttggtctt agatggggat gaggagtatg aggtaacaac ctttcggaca
    59641 gaggatgtct atgtggacta tcgcagaccc agtgcggttt cctttgtgcg ctcgctagaa
    59701 gaagacctca aacgccgtga tttcacagtc aacgcctttg ccttggatga gacaggagaa
    59761 atcgttgact tgttccatgg tttagaagat ttggaaaagc aagtcttgcg agcagttgga
    59821 gtggctagtg agcgtttcaa cgaagatgct ttacggatta tgcgtggttt ccgttttcag
    59881 gctagtcttg gttttgcact tgagccagaa acatttaaag ctatgaagac cttgacgccg
    59941 cttttggaga aaatttctgt agagcgtacc ttcgtcgagt ttgataaact cttgctggct
    60001 ccattttgga gaaggggctt ggcttccatg attgagagtc aagcttatga ctatctccct
    60061 gatatggcat ctagccagga caagctcaac agactgtttg atttggagac tgattttact
    60121 tttgaatcct ctgaacaagc ctgggcggct ttactatggg ctttggagat tgaaaatgcg
    60181 cagtcatttt tgaaatcttg gaagacctca cgccagtttg ccaagcaagt tcaggatttg
    60241 ctgattattt tggctctgcg tgaaaatgga gaattgagta agcgtgattg ttatcgcttt
    60301 gacatagatt tgcttttaca ggctgaaaat cttcgtcaag ctcaaggaaa agaagtcaac
    60361 ccacaagcca tcacagaaaa ataccaaagc ttgactatcc atgacaagaa agagattcag
    60421 attaatggcg gtattttgat caaggaatat ggctatcagc caggcccaga cttgggagag
    60481 attttaacag agattgagtt tgccattgtc gatggagaat tggagaataa tcgtgaagcc
    60541 atccatgctt acctgaggga gaaaaaatga gtgattttat cgttgaaaaa ctaagtaaat
    60601 ccgttggtga caagaccgtt tttagggata tttcctttat tatccatgac ttagacagaa
    60661 ttggtttaat cggtgtcaat gggactggca agaccaccct tttggacgtc ctttctggtg
    60721 tttctggatt tgatggggat gtcagtcctt tttcagctaa aaatgattac cagattggtt
    60781 acttgactca ggatcctgat tttgatgata gaaagacagt tttggatacg gttctatcta
    60841 gtgaactcaa ggaaatccag ctcattcgtg agtatgaatt gattatgctc gactatagtg
    60901 aggacaagca ggcgcgtttg gaacgtgtca tggcagagat ggactctctc caagcttggg
    60961 aaatcgaaag tcaggtcaag accgttctta gcaaattggg cattcaagac ttatctactc
    61021 ctgttgggga attgtcaggt ggtctgagaa gacgggtaca gttggcacaa gtcttacttg
    61081 gcaaccacga cctcttgctt ttggatgagc cgaccaacca tctggatatt gcgattattg
    61141 agtggctgac cctctttttg aaaaattcta agaagaccgt cctttttatc actcacgatc
    61201 gttatttctt agacgctttg tcaacacgga ttttcgagtt ggatcgtgca ggcttgaccg
    61261 agtaccaggg aaattaccag gactatgttc gcctaaaggc ggaacaggat gagcgcgacg
    61321 cggctcttct tcacaaaaaa gaacaactct acaaacaaga attggcctgg atgcgcagac
    61381 aaccgcaggc gcgtgcgacc aagcagcagg cccgtatcaa tcgattccat gatctgaaaa
    61441 aggaagtttc aggcagtagt gctgagacag acttgaccat gaactttgaa accagtcgga
    61501 ttgggaagaa agtcatcgag tttcaggctg tttcctttgc ctatgaaaac aagcctattt
    61561 tgcaagattt taatctcttg gtgcaggcca aagaccgtat cggaatcgtt ggggacaatg
    61621 gtgttggaaa atcaaccctg ctcaacttga ttgcaggaag tcttgagcca actaaaggac
    61681 aagttgtgat tggggaaact gttcgcatcg cctatttctc tcagcaaatt gagggtttgg
    61741 atgaaagcaa gagagttatc aattacctgc aggaagtggc agaagaggtc aagaccagtg
    61801 gcggttctac gacttcgatt gcagagttgc tggagcagtt ccttttccca cgttcgacgc
    61861 atggaacctt gattgagaaa ttgtcagggg gtgagaaaaa acgtctttat ctcctcaaac
    61921 tgcttttgga aaaaccaaat gttcttcttt tagacgagcc aaccaatgac ctagatattg
    61981 caactttgac agtcttagag aatttcttgc aaggttttgc aggtcccgtt ttaacagtca
    62041 gtcacgaccg ctatttcttg gataaggtag cgaccaagat tctcgctttt gaggatggca
    62101 agattcgtcc tttctttggt cattacaccg actatcttga tgaaaaagct tttgaaacag
    62161 atatggccaa tcaagtgcaa aaggtcgaaa aggaaaaagt ggtcaaggtt cgagaagaca
    62221 agaaacgcat gacctaccaa gaaaagcagg agtgggcaag tattgaaggt gatattgaaa
    62281 ccttggaaaa acgtatcgct gctattgaag aggaaatgca ggctaacggc tctgactttg
    62341 gtaagctggc tactctccaa aaagaattgg atgagaaaaa tgaagcactc cttgaaaaat
    62401 acgaacgcta tgagtatctc agtgaatttg atagttaaga ctattcgaaa atcaaagtgc
    62461 aaactatgtc ggcttcacat tgccgactca agtacagcct gtgaccggct tcctaatttg
    62521 cactttgatt tttattgagt ataaaagaat agaaaaatcc cgtctcatga aaggatttct
    62581 ctattctttt ttggtttctt gatgaaagat attttgccag gtttcgtggc gacgccagat
    62641 actggtatgg atgataccat ctaactcata gcagatgagt ttggtttttt gactgatgga
    62701 agtaatttga atgtccttta tagcagaatt taactctttt ttggtcttat aagcctcttt
    62761 atccatctgc tctccatctt ggcgaatata gacaaaatca tcagtcaaga gttcttctag
    62821 ttggtttcct tggtcaatca attgttcacg cataagcaat tttttataga cattgtctaa
    62881 aatttcatcc tcagggatag gtgctggttc gatatggaca tcggtatcaa agacgccaaa
    62941 acgctcctcc agcatagact cgacctgatc cgcgatttca tggctttcaa aaacagacaa
    63001 gtcaggattc atctctagtg taatatccag gtagatgttg ctaccgtagg tgcgacctct
    63061 ttgcgatttg accttgctga ttttgggaat ttccatgata gccttttggt agtcctcgag
    63121 caggcggtcg tcaaagccat ctgaaagact aaaggaagac tcgatgaaga tatcataggc
    63181 agtcttcaag ataaagaaag tgatgatgat agcaaccagt ttatccacaa tcggataatt
    63241 gaaactacta gctaggatgg caatggcggt tccaagtgag gtaacagcgt cagaaagatt
    63301 gtccttagca gctgccttca gcgccttgga gttggatttc ttactgaggc gagtattgta
    63361 gagatagacc acaaacataa tcgctgcaga aatgattcct agagttgcac caagaggatc
    63421 aatgaccgtt tcttcccgac tgagaatctt ttgaatggta tctcttagaa catcgaaacc
    63481 gacatagaac atgatgatag aagtgatcaa gcttgccaaa tcttcaatct tccaatgacc
    63541 aaaacggtgg tcacggtctg caggctggcg cgccatccga atcccgatta agagggccac
    63601 atttccaatg atgtccgata cgttattaaa accatcggcc accaaactgg atgaatgaag
    63661 gagatgacca gctgctaatt tagctgcaga caagatcaaa taggtcgaaa tactgataat
    63721 ggctccacgc tcagctaact tgagatttga gatagattgc ttcattcaac ttcctttcta
    63781 gtcacatagc attctaccat tatactggtt ttcaaggaaa aattcaaata aggcagtttt
    63841 tactctttga aaactcccca aaatttggta taatggtact actcaaggga gtagctggca
    63901 gaaacctgtg atagtgtcgt cattccgaat tttatgctga aaagtatgct ttccggccct
    63961 atcttaaaca gcgagacttg ttatgattaa caggtctctt tttgtttgtc gtgaaaagat
    64021 atgacagaaa gagagtctgt tttgcacaca atgtcaagga ggagacacat gtcaaaagaa
    64081 caaaaacgcc aagcgtttta tactcagagc cctgaagagg tcttgcaggc tgtggatgcg
    64141 accgagcaag gtttgtcatc aagtgaggcg gaaaagcgcc ttgccgaatt tgggcacaat
    64201 gaactcgaag aaggcgagaa acgatcaatc ttggtcaaat tcatcgagca atttaaggat
    64261 ttgatgatta tcatcctagt tgcggcagca atcttgtcag tcgtgacttc tggtggggaa
    64321 gatatcgcag atgccattat catcctagct gtggttatca tcaacgctgc ctttggtgtt
    64381 taccaagaag gaaaagctga agaagctatt gaagccctca aatccatgtc tagtccagtt
    64441 gcccgcgttc ttcgtgatgg acacatggca gagattgact ctaaagaatt ggtaccaggc
    64501 gatatcgttg cccttgaagc aggtgacgtg gtaccagcgg acctacgttt gatagaagcc
    64561 aactctctta aaattgaaga agcagccttg acaggtgaat ctgtaccagt cgaaaaagac
    64621 ttgtcagtcg agcttgcgac agatgctggt attggtgacc gtgtcaacat ggccttccaa
    64681 aactcaaacg taacctatgg tcgtgggatg ggtgttgttg tcaatacagg tatgtacact
    64741 gaagttggtc atattgctgg tatgcttcaa gatgcggatg agactgatac accactcaaa
    64801 caaaacttga acaacctttc taaggtcttg acctatgcta tcttggtcat tgcccttgtt
    64861 acttttgtag tgggtgtctt cattcaaggg aaaaatccac ttggtgagtt gttgacttct
    64921 gttgcccttg ccgttgcagc cattccagaa ggacttcctg ctatcgttac catcgttctt
    64981 tctcttggta ctcaagtttt ggccaaacga cattccatcg ttcgtaagtt gccagcagtt
    65041 gaaacacttg gttcaactga aatcatcgct tctgataaga ctggtacgct gactatgaac
    65101 aagatgacag tcgaaaaagt cttctacgat gcggttctac atgactcagc tgatgatatt
    65161 gaactaggtc ttgaaatgcc actacttcgt tcagttgtct tggccaatga tacgaaaatc
    65221 gatgtggaag gtaacttgat tggtgaccca accgaaacag cctttatcca atatgccttg
    65281 gacaagggct atgatgtcaa aggtttctta gagaaatatc ctcgtgtagc tgaattgcca
    65341 tttgactctg accgtaagct catgtcaaca gttcacccat tgccagatgg tcgtttcctt
    65401 gtagcagtca agggtgcgcc agaccaactc ttaaaacgtt gtcttcttcg tgataaggct
    65461 ggggatattg ctccgattga tgagaaggtt acaaatctca ttcatacaaa caattctgaa
    65521 atggctcatc aagccttgcg tgtccttgca ggtgcttata agattatcga tagtattcca
    65581 gaaaatctca cttctgaaga gcttgaaaat gatttaattt ttactggttt gattgggatg
    65641 attgaccctg aacgtcctga agccgctgag gctgttcgtg tggctaagga agcgggaatc
    65701 cgtccaatta tgattacagg tgaccaccaa gacacagcgg aagccattgc caaacgtttg
    65761 ggaatcattg acgcaaacga tacagaaggt cacgttttaa ctggtgctga actcaatgaa
    65821 ctgtcagatg aagaatttga aaaagtcgtt ggtcaatact ctgtttatgc ccgtgtgtct
    65881 ccagaacaca aggttcgtat cgtcaaggct tggcaaaaac aaggtaaagt cgttgccatg
    65941 acaggtgacg gtgtcaatga cgcgccagct ctgaaaacag ccgatatcgg tatcggtatg
    66001 ggaatcactg gtacagaggt ttctaagggg gcttctgata tgattcttgc agatgataac
    66061 tttgcgacta ttatcgtcgc agtggaagaa ggacgtaagg tcttctcaaa cattcaaaag
    66121 actattcagt acctactttc tgctaatact gctgaagtat taaccatctt cctatcaacc
    66181 ttgtttggtt gggatgtctt acagccggtt catcttttgt ggatcaactt ggtaacggat
    66241 accttcccag ctatcgctct tggtgttgaa cctgcagaac ctggtgtcat gaatcataaa
    66301 ccacgtggac gcaaggcaag cttcttctca ggtggtgttt tgagttctat catttatcaa
    66361 ggtgtactcc aagcagctct tgttatgagt gtttatggcc ttgcgattgc ttacccagtt
    66421 catgtgggtg acaatcatgc tattcatgca gatgccctaa cgatggcctt tgcaaccctt
    66481 ggtttgattc agctcttcca tgcctacaat gtcaagtctg tctaccaatc catcttgaca
    66541 gttggcccat tcaagtctaa gacctttaac tggtccatct tggtatcctt tatccttctc
    66601 atggcaacaa tcgttgtaga accgcttgaa ggaatcttcc acgtaaccaa actagacttg
    66661 tcacaatggg gaattgttat ggctggaagc ttctcaatga ttatcatcgt cgaaatcgtt
    66721 aagtttattc aacgcaaact cggttttgac aagaatgcga tttaagggag gtttcggatg
    66781 tcagcatatc aattaccgac cgtatggcag gatgaagcta gtaatcaagg agcttttacg
    66841 gggctaaaca gaccaacagc aggtgcccgt ttcgaacaaa acttgccaaa aggagaacaa
    66901 gcttttcagc tttattcact gggaacacca aatggtgtga aggttactat cttattggaa
    66961 gaattactag aagctggttt taaggaagcg gcttacgact tgtataagat tgctatcatg
    67021 gatggggatc aattcggctc agactttgtg aagctcaatc caaattccaa gattccagcc
    67081 ttattggacc agtcaggtac tgaaaacgta agagtctttg agtctgctca tattcttctt
    67141 taccttgctg agaaatttgg agccttttta ccaagtaatc ctgtggaaaa ggtagaagtt
    67201 ttgaattggc tattctggca agcaggtgca gcaccttttc taggtggggg atttggacat
    67261 ttcttcaatt atgctcctga aaaattggaa tatcctatta accgttttac gatggaagtg
    67321 aaacgccagt tggatttatt ggataaggaa ttggctcaga aaccttatat tgcaggcaat
    67381 gactatacga ttgcagatat tgctatctgg tcttggtatg gacagttagt tcaaggaaat
    67441 ctttaccaag gttctgcaaa attcttggat gcctcaagtt atcaaaatct agtaaaatgg
    67501 gcagaaaaaa ttgccaatcg tccagctgtt aagcgtggat tggaagtaac ttatacagaa
    67561 attaaatagc aaaaaagtca tcttcggatg gctttttgct acagttgagg gaaagggttt
    67621 gcagttatcg gcttttgtgc tataattgct ataatatagt aaaaagcaag aggagtgtga
    67681 ggaagtggaa aagaaaattg tgaaggatat cttattttta tctcaagtgt ctcagccggc
    67741 aagtcaggag gacctttatc ttgccagaga tttgcaggat acactcttag caaatcgtga
    67801 tacctgtgtt ggtctagctg ccaatatgat tggggtgcag aagcgcgtga ttatctttaa
    67861 tcttggcttg gttcccgtgg tcatgtttaa cccagtgctt ctgtcctttg aaggatctta
    67921 tgaggcagaa gaaggctgtt tgtccttggt aggtgtgaga tcaactaagc gttatgaaac
    67981 cataaggctt gcctatcgtg acagcaagtg gcaggaacag accattacct tgacaggctt
    68041 cccagctcag atttgccagc atgagctgga tcacttggaa ggacgaatca tttaggagga
    68101 aagcaaatga aacgaatagt ctttgaactt atttttatcg caacgacctg gtatatcttt
    68161 ttaccgcccc ttaacctgac cagctgggaa tttctcttct tcctctgtgg gcatttgtta
    68221 gttgtggcaa tcttatttgg ctttggcaag gggataaacc ttgtcaaaac ggttcatgtg
    68281 cgccacggta aggcggaagc tgccttaaat cttgagggtt tcaaaatcaa tcggttaggg
    68341 aaaattctgt tagcttcgat tggaggaatt cttctcttgg cagctttggt ttccttggta
    68401 acttccagca tgtttcaggc taaaaattat gccaatgtag tcacagttac ggaaaaagac
    68461 tttactgaat ttcctaagag tgacaccagt aaggttccta tcctagatag aagtactgct
    68521 gaaaaaattg gagaccgcta cttgggttcc ctaaccgata aggtgtcgca atacgtagcg
    68581 gcagatacct atacccaatt gacaattgat gggaaacctt atcgggtcac accactagaa
    68641 tatgcagacc ctatcaaatg gtttaacaat caagccaagg gaatcggtga gtatattaag
    68701 gtggacatgg taactggaaa tgcggatttg gtggacttga agacaccaat caagtattca
    68761 gactcggagt attttaaccg tgatgtcaaa cgtcacctgc gcttgaagta cccgaccaaa
    68821 atctttaaaa ctccatcttt tgaggtggac gatgagggca atcctttcta tgtagcaacg
    68881 gtttaccaaa agcaatttgg acttgctgtt cctcgtcctg cttcagtcat tatcttggat
    68941 gctacaaatg gagaaaccaa ggaatacagc ttatcagatg ttccagaatg ggtggacagg
    69001 atctatccag cagaggaaac cattgagcaa atcaactaca acggcaagta caaggacggt
    69061 ttcttgaatg ccatgatttc caagaaaaac gtgacccaga ctaccaatgg ctataattac
    69121 ttgtctatcg gtaatgacat ctatctctac acaggtgtga cgtcggctaa tgcggatgag
    69181 agtaatcttg gtttcatcct tgaaaatatg cgaacaggag aaatcactaa gtatagcttg
    69241 gcttctgcga cagaagaatc agcccgtgaa tcagcagaag gtgctgttca ggagaaatcc
    69301 tacaaagcaa ccttcccaat cctcatcaac ctcaatgaca agcctctcta catcatgggc
    69361 ttgaaggaca atgctggctt ggtcaaagag tacgccctgg tagacgcagt cgagtaccaa
    69421 aatgttatcg ttgctactac agtggaagag atgctcagca agtatgccaa taaaaacgac
    69481 cttgaaattg acaatgcaac gacagaaagc atcaagggag tagtagcaga cctcaaatca
    69541 gctgttatca agggagacac tgtctacttc tttaaagttg atggcaagat atacaaggtc
    69601 aaggcttcag tatccgatga ccttccttac cttgaaaatg gtaaaacctt cgaaggtcaa
    69661 gtaggaaaag acaattatct caagaccttt aagctacggt aaaaataggt tttttcagaa
    69721 agtatatgtt ataatagagt aaattaagac taatggagga caaagaaatg ggtttttatt
    69781 tgatggttgc ttcaatgcta ctcggactgc tcgctttgaa gataggtttt tctcagttca
    69841 aggagaacaa agataaattc ttatctatct taacaagttt agctgggcta gcccttgttc
    69901 tcgtggctgt ctggttagga tggcccaaat aaatagaaaa acctcggtca aaccgaggtt
    69961 tttcagatga atttcttggt tgtggctaaa aaatatgcta cactatcaat atgaagattt
    70021 taatccctac agcaaaagaa atgaatacag acttgccgag tatcgagaca actcttttaa
    70081 gatcagaaag tcaggctgta cttgatgcct tggctctcta ttctgccagt caattggaaa
    70141 gtttctacaa ggtatcagct gagaaggctg cggaagaatg tcaaaatatc caagctttga
    70201 aaaggcaaac tgctcaacac tacccagcct tgaagctttt tgatgggctt atgtaccgtc
    70261 atatcaagag agacaaactg accgaggtag aacaagccta tcttgaaaat catgtcttca
    70321 ttacctcggc tttgtacgga gtcgttccag ccttgtcgcc tatggcacct caccgtttgg
    70381 attttttgat gaaattaaaa gtcgctggta agactttgaa gagccattgg aaggcagcct
    70441 atgatgaagc tgtgaagcag gaagaagtga ttttctctct cttgtcatca gagtttgaga
    70501 ctgtattttc taaggaaatc agagcaaaga tggtgacctt caaattcatg gaggatagag
    70561 gcggtcagct gaagattcac tcaactatct ccaagaaagc gcgcggggcc tttctaacag
    70621 ctttaataga aaatcaagta caaactgtgg gggaagcacg tcgcttgaac tttgctggat
    70681 ttgtttaccg agaagatttg tcacaaccac agggattggt ttttgtaaag gaagtataga
    70741 aatcagataa gagaaaagtc agcacgatta tgctgacttt tttgataact tataaagtat
    70801 tggacaaatg aatctcattt gataaggtgt taagatgatt aaccaaattc atgattgaca
    70861 gatgatttcg gcaaataaac ttcttggtaa tccctgaaat atagaaatta gacacgatga
    70921 tatcgtaatc tgtctgattt aaaatctcag gacttgtttt taattcatcc caaatatcga
    70981 aggtaaagcg gttattacag taataggaaa gcatatcaac aaaggtaagg gatatagcat
    71041 ggtcaaagtt actgataatc aaaaccttga taggtggtcg attttctaac aactgagtag
    71101 agaggttttc agcatgggtt aagatggtgt acatcaagtg ttccaactgt tcaggatggt
    71161 catgctgtcc aattgcctga cggtattgag ccagttcttg acgcgcactt cccataaagt
    71221 ctgggaagta aacttcaaat tttttaatcg tcaatgcttt ttgttcaaat aagattgggg
    71281 tagaaaagat ttcctgtctt tcaaagaaag cagtgttgtg taaatgccaa atcagctcat
    71341 cgtggttagt aaaagtaatc ttatattgtt ttgataggcg ttctaatatt tgactaagta
    71401 attggtaaga gtatcttgct tgactgttat cttctaaaga gttgaagaat tcttgaggat
    71461 ctaggaaaat atcattctga agaaaagaaa taaaaatttg agcgattgta tctggagtca
    71521 tttcaagccc aaaatgttta gagaaataag caagtgtctc ctggaaattt ggaatgctct
    71581 ttaaaagagg ataatattct ttgtaaaagt ggttggggag gtcaatgaag tgaccatttt
    71641 taaccctgtg gatactgata gctatcatca gtttgtacat tctataaatt gaaaatcgca
    71701 ttggataatt cgtgatttta tagaagaagt cagcaaactc tgttaaatct tcctcaggaa
    71761 ggtcaggaaa aggccaatct aggaaataat agcgctcaga aaagtattgg gcaaaaaagt
    71821 aacgaatatc gatctcattt ccacgtatct cggatggagt aaaagataat tcaatttgaa
    71881 actgaaatga aagaaccttt gtaatatttc tgcccagtcg atagaggttg gcactactaa
    71941 agtaaagatt ttctattgtt cgataaatag gtagcccctc attgaagaac atatactcta
    72001 gtaattgaaa agattgagaa ttagcaagaa aatattgata aatatcttct acactagtgt
    72061 taacttctaa atctatcatg attccgttaa cagaagattg gatgttaata gatggaaagg
    72121 caatacgtaa ttcatttaaa tcacttttta agattcgttc tgtacatcct aatttttcgg
    72181 ctagttcatg taatttcatc caattacgat tctgaattag ggtttccatt aagcgtaatt
    72241 gtctttgaac ttttgtggat aaaaggtttc tcatacgggt atttcctcca taattcatta
    72301 tatctttttt tgtctaagta gtataaaaaa attagagcaa gaaaattgtc gttagtaatc
    72361 ggaaaaatta gaataatata agtggctttt aagtgcaaaa acagaatata ttaattgttc
    72421 agaaaatatt gattaatgcc tcaaatagtt gtacattgta aactataaaa tactatctag
    72481 gagtttaaaa tgaaacattc acataaaaaa tcatttgact ggtatagcat gcaacaacgt
    72541 tattctattc gtaagtatta ctttggtgca gttagtgtct tgctcggtac cgctttggta
    72601 ttaggtgcag cagctagtgt ccaaacagta caagcggaag aaaacaaaca agaaactacc
    72661 aatagtattt ctgttggtag gggagaagca gctactaaac cagcagaggt ttctgcgtct
    72721 aataaagaga aaacctatgc agctccaact gtagctaatc cagtagaaac gactccagtt
    72781 aaaactggag aagttactaa accagcagaa aaagttgaag aagcaaaaga caaaaaagag
    72841 gaagtaacgc atcaagatgc tattgacaag tcaaaattgt taacggctct ttcgcgtgct
    72901 aaaaagttag aaagcaagtt atatacagaa gcaagtgctg ctaacttgca aacaagtatc
    72961 caagctggtc aaagcttgct tgggaaagca gatgcatctg aagctgaatt atcagcagca
    73021 gagtcatcta ttcaatcatc tattattggt ctagaacttc gttctaactc taacaaagga
    73081 actgtatcag aaacgcctgt agcaaagaaa gctaatatag ttgaagcgaa ggaagagact
    73141 aaaccagctg taacaacgac tgaacgttca gctgttgata gcgctatttt gccaattagc
    73201 acagctgcta aagtagaaac aacttcagct ccagcatcta ctaatgaaat cttgaaacca
    73261 agtttgagcc tttctgatgc tcgccaaaat ccagctatcc gtaaggaaga tgttgataga
    73321 gggtatagtg gttttagaac agcaggaagt ggctttagag cggctggaag tggttttaga
    73381 gcagctggac cagaaaataa accaatctta aatccaaata atactattgc attttctgac
    73441 atcagtcagg gcttacattc atttcgtggt ataggacatt cacgtggtgg tcgtgaaatc
    73501 cattatgatg taacgacagt acgtagaggt aatagattga atttcacaat taaatactct
    73561 ggtccaggtg aatttgttaa taataatttt atcttggata aaggggatgg atttggaaat
    73621 ccttcaaatg caacgatcac aagttcaaat ccaagagtaa gggagcaatc aaaatctatt
    73681 agtcagggtg ccaactacgt atctcactca ggatacagta tgacctctgc tacttcaaca
    73741 aatacggaac aaactatcag atttagtttg cctatcatta atccaaatgg tgatttgtct
    73801 gttcgtttga aaccagttac ttttaacgtg gaccaaggtg gtggtggtgc cgctactagc
    73861 aatgacccat acagtaactc caactattat catagagcaa atccactcct cttggatgca
    73921 aacccttatg gtggtactaa taataagact gtttcagaag acattgactt ccaaactgtc
    73981 tatcttccaa ctagtaagtt accagaaggt caaactagat tagttcgaga aggtgaaaaa
    74041 ggacaacgtc aaattaccta taaagtacat cgatttggta acgaaacact tttaggattg
    74101 ccaattagta atagagttac taaagaagct aagccacgta ttatgcaaat tggtgtggct
    74161 aaagagttaa tcgatacagt aaaaccacgt gttgatcaaa ataaagttgg tgatacaaat
    74221 aacctcactt tctatcttga taacgatgga aacggtgttt atactgaggg cgtagacgaa
    74281 cttgttcaaa aaattgctat taaagatgga gccaagggtg aaaaagggga ccaaggtgaa
    74341 cgcggtctaa ccggagcgca aggtactaaa ggtgaaaagg gagatcaggg tgaacgcggt
    74401 ctaaccggag cccaaggagc taaaggtgaa aaaggtgaac aaggtcttca agggcgtgat
    74461 ggtgaacaag gaccaaaagg agaagatggg aaaaccccaa cagttaaagt aactgatggt
    74521 caagatggaa cgcatacaat tacaattaac gatggtaaag gtggtataac tactacagta
    74581 gtaagagatg gatttgatgg tgcaagccct cttgtttcta ctcatagaaa tgaagcagat
    74641 aaaacaacaa ctgttatttt ctattatgat ctaaatgata ataatcaatt tgatgaagga
    74701 gatacaaaac ttaaagaagt tgttatcgca gatggaaaac aaggaccaaa aggtgacaaa
    74761 ggtgataacg gaaaagatgg attcacacca gaagtaacag ttacagataa caataacgga
    74821 acacacacca tcacaatcac acaaccagac aacagaccat cattaacaac aatcgttaaa
    74881 aacggtgaag atggaaaaac accaaaagtc aaagcagaac gagatgatgc gaagaaacaa
    74941 acaacattaa cattctacat tgacaaagat ggagatggaa gttacacagc aggaaaagac
    75001 gagttagttc aaacaacagt agttaaagac ggacaagacg gagctgcagg agcatctgga
    75061 cgtgatggaa aagaagtatt aaacggaaaa gcagacccaa caacagaagg taaagatgga
    75121 gacacattcg taaatacaca aacaggagat gtattcgtta agaaaggtaa cacttgggaa
    75181 ccagcaggaa acatcaaagg accgaaaggt gacaaaggtg cagatggtgc taaaggcgaa
    75241 aaaggagacc gaggcgaacg cggtctaacc ggagcgcaag gtactaaagg tgaaaaggga
    75301 gatcagggtg aacgcggtct aaccggagcg caaggtacta aaggtgaaaa aggagaccga
    75361 ggcgaacgcg gtctaactgg agcgcaaggt caggcaggtc gtgacgctgt aactccaacc
    75421 gtaaccgtta aagataataa aaatgacggc actcatacta tcactattaa cgacggtaga
    75481 ggtaatgttg caagtactgt tgtaagagat ggtttcgatg gcgcaagtcc attagttgcg
    75541 actcaacgaa atgaagcaga taagacaaca actgttatct tctattatga tcaaaatgga
    75601 aataatgaat tagatgcttc tgataagaaa ttaaaagaag ttattattgc agatggtgcc
    75661 aaaggtgaac aaggtcttca aggtcgtgat ggtcaagacg gagctcaggg acaagcagga
    75721 cgcgacggta aagacgtgtt gaacggcaaa gctaatccag aagtaaatca aggtaaagac
    75781 ggtgataaat acgtcaatac agaaacaggc gacgtcttcg ttaagaataa cggcaactgg
    75841 gataaagagg gcaacatcaa gggacctaaa ggggacaaag gtgaacgcgg agaagatggt
    75901 aagactccag aagtaactgt aactccaggt aaagatggcc atagtactga cattacattc
    75961 actgttccag gtaaagatcc agtaaccttc actgtaaaag atggtaagaa tggtaaagat
    76021 ggccgtgcac cgaaaatcaa agtagaagat attacttcac cttcaagaat tagacgcgat
    76081 acagatgctg ctgcaactcc aacgcgtaac ggtatccgtg ttacagttta tgatgatgtt
    76141 aatgacaatg gggtatacga cgaaggtgtc gataaagtat taaatagtaa agatatttat
    76201 aacggtatag atggacgtga tggttcagct ccaactatta ctacaaaaga taatggagat
    76261 ggaactcaca ctatcacagt tcaaaaccca gatagttctg aatcaacaac agttgttaaa
    76321 gatggtaaag acggtaaaac tgcgaatatc actacaacag aaaacccaga tggaagccac
    76381 acaattacgg tgacaaatcc agatggttca actaaagaaa ctgttgttaa aaacggtaaa
    76441 gacggtaaga ctcctaaagt tgaagtaacg gataacaacg atggaactca tactgttaaa
    76501 gttacagatg gagacggcaa tgttaccaac gctatcatca aagatggtaa agacggtaaa
    76561 gctgcaacag caacaactac tgaaaatcca gatggaagcc acacagtaac aatcactaac
    76621 ccagacggaa ctaagaatga gtttgttgtt aagaatggac gtgacggtgt tgacggacgt
    76681 actccaaccg catctgttcg tgataatgga gacggaagtc atacaatcgt tattacaaat
    76741 ccagaaggtg tgacaactga aaccacagtt cgtgatggta aatcaccaaa agtgactata
    76801 actgatgaac aaaatggaac tcataagatc tctgttctaa atggtgacgg aacaactact
    76861 gaaacaatca ttaaagatgg taaatcacca gtagcaacag ttagagataa ccaagatggt
    76921 acttacacta ttcgtgtgga aaacggtaat ggtactgttt ctgaaaccac agttcgtgac
    76981 ggtaaatcac caactgctaa ggttgtggat aatggagatg gaactcacac tatcacagtt
    77041 gtgaactcag acggaacaac tacaacaact acagttcgtg atggtagaga accaaaactt
    77101 gaagttattg ataacaacga tggttcacac actattaaag tgacaggtgc tgatggtaaa
    77161 ggaacgacaa ctacaatctt tgatggtaaa tcaccaaaag cgaacatcgt tgataacgga
    77221 gatggaactc atacattaac aatcgtagat tctgatggtc gtgaatacaa atctattatc
    77281 aaagatggta aagacggcaa agatagcgtt tcaccaactg taactgttaa aaataataac
    77341 gatggaactc acgttgttac aatcactaat ccagatggaa gtaagacaga aatggtgatt
    77401 aaagacggta aagatggaaa atgtggatgc caagacaaac cagtaacacc atcaaatgac
    77461 aaaccagttc ctccaacacc aaatgtgccg acaccagaag taccggttaa acctgtgcca
    77521 gcgcaaccaa caccaaatgt accgacacca gaagtgccag tacaaccaac tccagctgtt
    77581 ccaacaccag aagtaccggt taaaccagta ccagcggttc cagaacaacc agtagtacca
    77641 acaccggctc aaccagcaac tccagtaaat gctaatccag tagcaccaac tacaggtaaa
    77701 gaaaaccgtg gggacaaatt acctgaaact ggaagccaat ctgattatat ctctgttctt
    77761 ttaggtagcg gtattctatt gagcctatat gtaggacgaa gaaaagaaga ttaatcagcc
    77821 aaaagcagtc actaatttct cgaaagaaga tgataagtga tagatctcga atgaaagaat
    77881 attcttagaa tgattttcct atgatggaaa agactgctaa aaaccttgag tggtaacgct
    77941 caaggttttt ttggatggct gatgtttgtc tgaaaatctt gattgagaaa taaaaagcca
    78001 ccctattagg tggctataat tgatttagac tttctaaaat tttctatttt ttactgaatc
    78061 gcttcgacca agtcttgagc ttgtttttca agtgagttta ggactgtttc ttcaagaacc
    78121 aattttccgt ctgcccaggc agagtcatta acacgtgcag cagtgaaatc accaacgcct
    78181 tgtgtacgga taaatggcaa gaggtctttg tagatagcga aaagttgatc gtgccctgca
    78241 ttggctacag atgatactgt gacaaacttg tcttgaaggg cagaaacgcc acgtgtatca
    78301 gacaagtcaa gggcacgaga tagccagtca agcaagtttt tcactgtacc agggatagag
    78361 aagttgtaga ctggagagaa aatccagata gcatccgcaa cgagaactgc ttcacgagca
    78421 gcagctacag ctggatgtgt tggaacttcc aaatcttggc tgaagagagg aagggctgaa
    78481 taatcaaggt agctaacttc cgctttacca gcaagtgctt tctcagcttc gagcgccatt
    78541 tggtggttga aagaaccttg acgtagtgat ccgacgataa ataatacttt tttagacatg
    78601 atgtgtctcc tttttcttaa aatttcgaga actctctcgt tgttataaaa tatattacaa
    78661 caaaacaaaa gaacttgcaa gaaatttgct cagagtttat ttgaaaattg taaaatttcg
    78721 gaaactctaa tcatttgtga ctgaaaaagt aagaactgtt tcactttcaa aatcggtttt
    78781 gtttgaaggg agaaatagaa ttggttgctc aaagcacagc tttgaggttg cagataaagc
    78841 tgacgtggtt tgaagagatt ttcgaagagt attcttatat tcacttgtaa taaagcttaa
    78901 tagatggtaa aatagacgag tgaaaaaaag acaaaacaaa gcaaaaaata atctactgtg
    78961 gcagtatggt ctagggatga cgattttgtt tgtggttatc agtggttcct ttctgtatat
    79021 ggtttctctt agcatgaaac cctatcaaac agctaaaagt gaaggagaaa aattagctca
    79081 gcagtatgca ggattagagc aggtcgatca ggttgattta tacaatggct tggaatctta
    79141 ttacagcgtt cttggtcgta ataaacagca agaagcgctt gctgtcctga ttggtaaaga
    79201 tgaccataag atttacgttt atcagctaaa tcagggtgtt tcacaagaaa aagcagaaac
    79261 ggtttctaag gaaaagggag ctggcgagat tgacaagata acctttggcc gttatcaaga
    79321 taagccaatc tgggaagtta agtcaggatc tgatttttat ctagtagatt ttgaaacagg
    79381 agcattggtc aacaaggagg gcctatgaaa ctatccaacc gtgttttaga aatggaagaa
    79441 agtgtgactt tggctgctgg agcccgtgcc aaagcactga aggctgaggg tagagatatt
    79501 ttgtctctaa ccttgggtga gccagatttc actactccca aaaatatcca agatgccgcc
    79561 attgcatcga ttcgagatgg gcgtgcttct ttttatacag taacctcagg tctgccagag
    79621 cttaaggcgg cggtcaatag ctactttgag cgcttttacg gctattctgt agcgtcaaat
    79681 caagtgacag tcgctgcggg agccaaatat tctctctata ccttctttat ggctgtggtc
    79741 aatccaggtg atgaagtcat catcccaacc ccatactggg ttagctatgg agatcaggtc
    79801 aagatggcag aaggcgttcc cgtctttgtt tctactaagg aagacaatca ctttaaggtg
    79861 accgtagatc agttagaagc agctcgcact gacaagacca aggttttggt gctgaattcg
    79921 ccatctaatc ccacaggtat gatttacacc cgtgaggaac tcttggcaat tggaaactgg
    79981 gctgtagaaa atgatattct catcctagca gatgatatct atggccgctt ggtttataat
    80041 ggtcatgagt tcacaccgat ttctagccta tcggaagcga ttcgcaagca aacagtggtc
    80101 atcaatggtg tgtctaaaac ctatgccatg actggttggc ggattggtta tgccgttgga
    80161 gaagcagata ttatcgctgc catgtccaag attgcaggtc aaacaacttc gaatccgtca
    80221 gcagtagccc aatatgcagc agttgaggct ctatcaggtg agcaagatac tgtagaaagc
    80281 atgcgtcagg cctttgagga acgtcttaat accatctatc ccctccttgc agaggtacca
    80341 ggatttgaag tggtcaaacc gcaaggggcc ttctatctct tcccaaatgt caaaaaggcc
    80401 atggagatga aaggctacac ggatgtgaca gactttacaa ctgctatctt agaagaagcc
    80461 gaagtggcct tggtaacagg agctggattt ggagcaccag aaaatgtccg cctcagctat
    80521 gcgacagacc tagacacgct taaagaagca gtcgaacgct tgaaagcatt tatgggtagt
    80581 gagaatgatt gatcattttg agattaaggt aaaggattta caaatttcag aaggatttta
    80641 taggagtttt ctcgctcctt tggactataa attggctttt aagactagtt ctctaattag
    80701 ttttctatcc ccgaacagcc ctcatcctgg tggtgatttt tggctgactc agggaacaca
    80761 agatcctgtt cattttgctt ttttagcaga aaataaggaa gaagttcagg cttgttatga
    80821 ggctggctta gaggcaggtg ggcgagacaa tggggctcct ggttatcgaa gtgagcatcc
    80881 gatttactat gctgctttta tgattgacct ggatgggaac aatatagagg tggtttgcca
    80941 taaagaataa aaaagaaaag gaaaaataat gacaaaacgt gtaacgatta ttgacgtaaa
    81001 agactatgtt ggtcaggaag tgacgattgg cgcttgggtt gccaacaaat caggaaaagg
    81061 aaaaatcgct ttcttacaat tgcgtgatgg aacagccttc tttcaaggtg tggcttttaa
    81121 accaaacttt gtcgaaaaat ttggtgaaga agtgggactt gagaagtttg atgttatcaa
    81181 acgcttgagc caagaaacgt ctgtttatgt gacaggtatt gtcaaagagg acgaacgttc
    81241 taaatttggc tatgagttgg acatcacaga catcgaagtg atcggtgaat ctcaagacta
    81301 cccaatcaca ccaaaagaac acggaacaga ctttttgatg gataaccgtc acttgtggct
    81361 acgctctcgt aagcaagtag ctgtgttgca aatccgtaac gctattatct atgcaactta
    81421 tgagttcttt gacaagaacg gttttatgaa gtttgacagc ccaattcttt caggaaatgc
    81481 ggcagaagat tctacagaac tctttgaaac tgactacttc ggaacgccag cctacttgag
    81541 ccaatcaggt cagctttacc tagaagcagg ggctatggct cttggtcgtg tctttgactt
    81601 tggtccagtt ttccgtgctg aaaaatcaaa aacacgccgt cacttgactg agttctggat
    81661 gatggatgct gagtactcat acttgacaca tgatgagtcg cttgacttgc aagaagctta
    81721 tgtgaaagct cttctacaag gtgttcttga ccgcgcgcct caagccttgg aaaccttgga
    81781 acgtgataca gaactcttga aacgctacat tgcagagcca ttcaaacgta tcacttacga
    81841 tcaagccatt gacctcttgc aagagcatga aaatgatgaa gatgctgact acgagcatct
    81901 tgagcatggt gatgactttg ggtcaccaca cgaaacttgg atttcaaacc actttggtgt
    81961 gccaacattt gtcatgaact atccagcagc catcaaggcc ttctacatga aaccagttcc
    82021 tggaaatcca gagcgcgtgc tttgtgcaga cttgcttgct ccagaaggct atggagaaat
    82081 tatcggtggg tctatgcgtg aggaagatta cgatgccctt gtcgctaaga tggatgaact
    82141 tggcatggat cgtacagaat atgaattcta ccttgacctt cgtaaatacg gtacagttcc
    82201 acacggagga tttggtatcg gtatcgaacg tatggtaacc ttcgcagcag gaacaaaaca
    82261 tatccgtgaa gctattccat tcccacgtat gttgcaccgt atcaaaccat aagaacagga
    82321 aaacgcccat gtggcgtttt ttcgaattct agtgttttta cttgcgtaaa aaaatttttt
    82381 ctagtataat agtttattgt gagcgaacct cacttacccc ttgcaaagtc ttggggtcat
    82441 tagaccaaaa ggaggaacat atcaatggct aaatacgaaa ttctttatat cattcgtcca
    82501 aacattgaag aagaagctaa aaacgctttg gtagcacgtt ttgactctat tttgactgac
    82561 aacggtgcaa ctgttgttga atcaaaaact tgggaaaaac gtcgtcttgc atacgaaatc
    82621 caagatttcc gtgaaggact ttaccacatc gttaacgttg aagcaaatga cgatgcagct
    82681 cttaaagagt ttgaccgtct ttcaaaaatc aacgctgaca ttcttcgtca catgatcgtc
    82741 aaaattgacg cgtaagaagg taaactatga ttaacaatgt tgtacttgta gggcgtatga
    82801 cacgtgacgc tgagttgcgt tataccccat caaatgtagc agttgcgact tttactcttg
    82861 cagtaaaccg tacatttaag agtcaaaatg gtgaacgtga ggctgatttt atcaatgtcg
    82921 ttatgtggcg ccaacaggct gaaaatcttg ctaactgggc taaaaaaggc tcacttatcg
    82981 gggtgacagg tcgtatccag actcgtagtt acgataacca gcaaggacaa cgtgtctacg
    83041 tgacagaggt cgtggctgag aatttccaaa tgttggaaag ccgtagtgtg cgtgagggtc
    83101 acacaggtgg agcttactct gcaccaactg caaactattc agcacctaca aattcagtac
    83161 cagacttttc acgtaatgaa aatccatttg gagcaacaaa cccattggat atttcagatg
    83221 atgatttacc attctaatgg acaactaaac ttataaagga gaaaaaacat ggctcaacaa
    83281 cgtcgtggcg gattcaaacg ccgtaaaaaa gttgattaca tcgcagcaaa taaaattgaa
    83341 tatgttgatt acaaagatac tgagcttctt agccgtttcg tttcagaacg tgggaaaatc
    83401 cttcctcgtc gtgtaacagg aacttcagct aaaaaccaac gtaaagtaac aacagctatc
    83461 aaacgcgctc gcgtaatggc tttgatgcct ttcgtaaacg aagattaaag aaaagacccg
    83521 gttgggtctc tttttcatga gcttgaaaac aagaaagcga attaagaccc caacgggtct
    83581 tttttcacaa gctttgaaat gagagagcga gttaggctca gtggctccct ttttacgagt
    83641 ttgaaaacaa gagaacacat tacaagcacg atggagcttt ttcataaata tgtctctttt
    83701 ctcatccaag aaattaaaat aaaaatgata aactttttga aaatagggga tttgcctact
    83761 ttatgatata atggaaagag ttagattgaa agaggtagtg agatggacgc gaaattaaga
    83821 tacaaggcaa agaagatcaa gattgtcttt tttgatattg atgatacatt gcggaattca
    83881 aagacagggt ttattccaac tacaattccc actgttttta aacagttgcg tgaaaaagga
    83941 attttaacag gaatcgcctc tggacgtggc atttttggtg ttgttccaga gattcgtgat
    84001 ctcaagcctg acttttttgt aactttgaat ggggcttata tcgaagataa aaaaggtcag
    84061 gtcatttatc agcatcagat tggaaagtca gatgttgagg agtatatctc ttgggctaag
    84121 caagaaggaa ttgagtatgg cttggttggg agtcatgatg ccaagttgtc gactcgcacc
    84181 gatatgatga gtgaagctat caatccaatt tatcccgact tagatgtaga tcccgatttc
    84241 catgaaaaag aagatatcta tcagatgtgg acttttgaag ataagggaga tgacttgcac
    84301 ttgcctgaca gtctctcaga caaacttcgc atggttcgtt ggcatcaaca ttcgtctgat
    84361 attgtgccta tttcaggctc caaagcgacg ggggtggaaa aggttgtgga acaccttggc
    84421 ttgaaaccag agaaggtcat ggtttttgga gatggtctca atgacttgga actctttgat
    84481 tatgctggaa tcagcgttgc catgggaatt tctcatgata aaatcaaaga aaaagcagat
    84541 tatattacaa aaacattaga agaagatggc atttttgatg ccttagaagt atttggtatg
    84601 gtagaaaaag aattgcattt tccacaagta gacattgaaa cagtagaagg tcctcttgcg
    84661 actattaaga ccaatcacgg agacttacgt atcaagcttt tccctgaaca tgctcctaaa
    84721 acagtggcta actttgtatc tctttcaaaa gatggctact atgatggtgt cattttccac
    84781 cgtattatca aggactttat gatccaaggt ggagacccaa ctggaactgg tatgggtggc
    84841 gagtcaatct acggcgaatc ttttgaggat gaattctcag aagagcttta caatatccgt
    84901 ggtgctcttt ccatggcaaa tgctggccca aataccaacg gcagccagtt ctttatcgtg
    84961 caaaaccaac acctacctta ttctaagaaa gaaattactc gtggtggttg gccagaaccg
    85021 attgcagaaa tctatgccaa tcaaggtggg acacctcacc tagaccgccg tcacacggtt
    85081 tttggtcagt tagctgatga agcatcttac gctgtcttgg atgccattgc tgctgttgag
    85141 acaggagcta tggacaagcc agttgaagat gttgtaattg aaactattga aatcgaggac
    85201 taagatgaaa atcggtgata agctaaaggg gcgtattaca gggattcagc cctacggtgc
    85261 ctttgttgag ttagagacgg gtgatacggg gctgattcac atttcagaaa ttcggacagg
    85321 atttattgaa aatattcatg aaaccttgaa agtcgatgaa gaggttcaag ttcaggtagt
    85381 ggatttagat gaatttacgg ggaaagccag tctttctatc cgcactttgg aggaagaaaa
    85441 gtaccagttt cctagacgga gacgcttttc aagcgaccgc tttaactacg gttttgctcc
    85501 ctttcgacga atgctaccaa tctggactgg agaagccctg cactatttaa aaaagaagaa
    85561 gtagtttaga gttttatatt ttttgtaatg ttaatataaa tttgctataa taggaccatg
    85621 gaagaagaac aattattaaa atcaggagag cgcattaacc agctcttttc gacagatatc
    85681 aaaatcattc aaaatagaga ggtttttagc tattcggtgg atagtgttct cttatcacga
    85741 tttccacgtt ttcctaagaa ggggttgatt gtagatttct gtgctgggaa tggagcagtg
    85801 gggctttttg ctagcactcg tactcaagca cagatattgt ctgttgagat tcaggagcgt
    85861 ttggcggata tggctgaacg ctctgtccgt ttgaatggat tagaggagca aatgcaggtc
    85921 atctgcgatg atttgaaaaa tatgcctgct cacattcagg ggagtaaggt ggatatgatt
    85981 ttgtgtaatc caccctattt caaggtggat cctcattcta atctgaacga gagtgaacat
    86041 tatctcttgg ctcgacacga aatcacgact aatttggaag aaatctgtca tagtgcccag
    86101 agtattctca agtctaatgg gcgtttggcc atggttcatc gtcctgatcg acttctggat
    86161 attttggata cgttaaaacg acataatcta gcccctaagc gcctgcagtt tgtttatcca
    86221 aaaagagaaa aggaagccaa tatgcttttg attgaggcga tcaaggatgg ctcaacaagt
    86281 ggctttaagg tcttacctcc tttgattgtc cacaatgatg atggctctta tacgcccgaa
    86341 atcgaagaga tttattatgg atcataaggc ttatatgtac gttctggagt gtcgtgatgg
    86401 atcctactat ataggctata cgactgatgt gagaagacgc ctcgctatcc acaatagtgg
    86461 gaagggagcc aaatatacac gagcacgctt gccagtcaaa cttatctatg ctcaaggttt
    86521 tgccagtaag gaagaagcca tgtcggctga agctcttctc aagcgtaaga agaggccaca
    86581 gaaggaagaa tttttatctg aaaatcaaga tagaaattta ctcagttatt ttgaagaatc
    86641 gtggggagtc ctttgactcc tcttaccttt gtcaaaaagc gaaaaaaatg ctacaataaa
    86701 gaaaataaac aaaatgaggt attatcatgt ccaagattct agtatttggt caccaaaatc
    86761 cagactcaga tgccatcgga tcatctgtag cttttgccta ccttgcaaaa gaagcttacg
    86821 gtttggatac ggaagctgtt gcccttggaa ctccaaatga agaaacagcc tttgtcttga
    86881 actattttgg tgtggaagca ccacgtgtta tcacttctgc caaagcagag ggggcagagc
    86941 aagttatctt gactgaccac aatgaattcc aacaatctgt atcagatatc gctgaagtag
    87001 aagtttacgg tgttgtagac caccaccgtg tggctaactt tgaaactgca agcccacttt
    87061 acatgcgttt ggagccagtt ggatcagcgt cttcaatcgt ttaccgtatg ttcaaagaac
    87121 atggtgtagc tgtgcctaaa gagattgcag gtttgatgct ttcaggtttg atttcagata
    87181 cccttctttt gaaatcacca acaacacacc caacagataa aatcattgct cctgaattgg
    87241 ctgaattggc tggtgtgaac ttggaagaat atggtttggc aatgttgaaa gctggtacca
    87301 acttggctag caaatctgct gaagaattga ttgacatcga tgctaagact tttgaactca
    87361 acggaaataa tgtccgtgtt gcccaagtga acacagttga catcgctgaa gttttggaac
    87421 gccaagcaga aattgaagct gcaatgcaag ctgccaacga atcaaacggc tactctgact
    87481 ttgtcttgat gattacagat atcgtcaact caaactcaga aatcttggct cttggtgcca
    87541 atatggacaa ggtcgaagcg gctttcaact tcaaacttga aaacaatcat gccttccttg
    87601 ctggtgccgt ttcacgtaag aaacaagtgg tacctcaatt aactgaaagc tttaatgcgt
    87661 aagattttgg gtgtcagctc aaaatcggaa agtctagttt gccttatatc gaaaggagtt
    87721 tcggctcctt tttttctagg agtgaagtat gttagaaaat ggcgatttga tttttgtgag
    87781 agatgggtca gacatgggac aggccatcca gacttccaca ggtaactata gccatgttgc
    87841 catttatttg gatgggatga tttatcatgc tagtggacag gctggtgttg tctgtcaaga
    87901 accggcagac ttctttgagt ccaatcattt atacgacctc tatgtttacc cagaaatgga
    87961 tatccagtcg gtgaaggaaa gagcttgcag acatcttgga gcaccctaca atgcttcttt
    88021 ctatccagat gcagctgctt tctactgctc ccagtatata gcagaaatcc tacctatttt
    88081 tgaaactatt cctatgaaat ttggagatgg ggaacaggag attagtgatt tttggaggga
    88141 gtattacata gaactaggtc tgcctgttcc tctgaaccaa gctgggacca atcctagtca
    88201 gttggcagca tcgcctctgt tacaatgtaa agaaagggat cttcatgatt cagattttta
    88261 atccatctcg tttgacgaga cagccatttt tggagaattg atccgctatc tggaccagta
    88321 tgaggatgtg attctacggg aaattaagtc tcagtttcca gatgttgcag ttgataaact
    88381 catggaagag tatataaagg caagcttgat tctacgtgaa aataagcgct attaccttaa
    88441 ttttcctacg cttgaatcac ttgatagtct tgaactggat caagagattt ttgtcagaga
    88501 agctagtccg gtctatcaag ccttgttgga gcagagtttt gagacggaat tgcgcaatca
    88561 aatcaatgca gctattttag ttgaaaagac ggactttgcg cgcattaaaa tgaccctgtc
    88621 caattatttt tacaaggtca aacagcagta tcctttgaca gaaaaacagc aggagctcta
    88681 tgacatttta ggagatgtta atcctgagta tgccctcaag tatatgacgg cttttttgtt
    88741 gaaatttctc aaaaaagacc agcttatgca gaaatgccgt gatatctttg tggacagttt
    88801 ggttgtctta ggctatattg tgcaaaatga agatagaaag tatgagttgg ctatcgattt
    88861 tgataaggag agattaactt tctacttagc gtgatttctt gtttctgagc acattgtttg
    88921 actttcctta gtattcggta taaactatat gtaaccggta acacatatcg gaataaacta
    88981 aaggagacaa tcatatgtca cttgaaaaca aattggaaca agcaacaggc gctgtcaaag
    89041 aaggttttgg taaagttact ggagacagca agacagaact tgaaggagct gttgaaaaaa
    89101 cagttgctaa ggcaaaagac gttgtagaag acgcaaaagg tgctgtagaa ggtgccgttg
    89161 aaggtttgaa aaacgttttt actaaataat aggaaaaaat caagggtttc attttccctt
    89221 gattttttct attcttataa ataattttct gcgacggctg tatctcctgg gtaggattct
    89281 ttcttgccct ggatgatttg gtaacaatcg gctcccttac ccgcaataat aactgcatct
    89341 aattcgtgat ttgtgatagc cattgccgcc ttgatggctt cttggcgatc cgcaatcttt
    89401 tcaacaggat gattgatgta gctactaatt tcatctgcaa tggccattgg gtcttcatag
    89461 ttagggtcat cagcagtcag aaagacttga atctcagggt gttgattgag gaggaggcca
    89521 aagtccttac gacgactttc tcccttgttt cctgttgatc ccagaaccag agcaatcttt
    89581 ccggtttgat gagtttcaac cacattgatg agttttttca gactatcccc attgtgggca
    89641 tagtcgatga agaccttggc tccatttttc tgagtgagga cttccatacg accaggaacg
    89701 cgggttgcag cgatgccttt tttgatgtcc tcaagacttg ctccgagacg gagacaagca
    89761 agtccagcag caactgcatt ttcttggttg aagttgccaa tgagttggat atcataatct
    89821 ccagcgagtt tacccgtagc tgaaaagcta aaggctttgg aattctcgat ttggttatca
    89881 aattggctac catagaaatc atggtcttga tcttcaacct gttctttcaa gactgagaag
    89941 tggtccatgt cactgttaat gatgactgct cggctatttt ccatcaagag acgcttgtgg
    90001 tagaaatagt cttcaaagct agggtgttca atcgggccga tatggtcagg agtgatgtta
    90061 agaaagactc ctacatcaaa ggtcagtcca tagactcgat ggactagata ggcttggcta
    90121 gagacttcca ttacgagatg gcttcttcca ttcttaacag cttgagccat catgtcaaag
    90181 aggtcgatat tttcaggtgt tgagaatgaa gatttaaaga aagttgtgcc atccaaagtt
    90241 gtattcatgg ttgataagag ggcggttggg taacgttgag ataggatgtt gtaagcaaag
    90301 taagctgctg ttgtcttacc cttagttcct gtgaaggcga gaattttgag tttctcttgt
    90361 ggattaccat agaactccat ggcaatcaaa ctcatggctt tctttatatc gttcacaatg
    90421 atgacaggga taccgacttc gtagtccttt tcagctacat accaagctaa accttgtgtt
    90481 atagcagaaa gaaggtattc ttttttaaag gcagcacctt ttgcaaaaaa aagagtgtct
    90541 tctgttactt ttcggctgtc gtagctgatg ctatcaaaaa caactttgct gtagttgtag
    90601 tggtaatgac cttggtcaat aatttcgcga aaaaggccat ctttctttaa aatatctaat
    90661 acagtttcaa tttttatcat actttctatt gtaaaccgaa agtcgcaaat ttacaagtaa
    90721 caaggaaaag tttataatgg aagataagga gtttttccta gttatcaaaa ttgaatgagg
    90781 aatctatgtc gcacgaaaac aatcaccagc aggcccagat gttacggggg actgcttggc
    90841 taacggctag taactttatc agtcgcctac tcggggctgt ttacattatc ccttggtaca
    90901 tctggatggg ggcttatgca gctaaggcaa atggtctctt taccatgggt tacaatatct
    90961 atgcttggtt cttgttggtt tcaacagcgg ggattccagt tgcggtggcc aagcaagttg
    91021 ccaagtataa taccatgcga gaagaagagc atagctttgc cctgattcgg agcttcttag
    91081 gctttatgac aggactaggc ctggtttttg ctttagtctt gtatgtcttt gctccttggc
    91141 tagcagactt gtctggcgtg ggcaaagact tgatcccaat catgcaaagc ttggcttggg
    91201 gagtcttgat tttcccgtct atgagtgtta tccgaggatt tttccaaggg atgaataacc
    91261 tcaaacctta tgccatgagc caaattgctg agcaggtcat tcgtgttatc tggatgctcc
    91321 tagcaacctt tatcattatg aagctcggtt caggagatta tctagcagcc gttacccaat
    91381 caacctttgc tgcctttgtc ggtatggtag ccagttttgc agtcttgatt tatttccttg
    91441 cccaagaagg ttcactcaaa agagtctttg aaacaggaga taagattaac agtaagcgtc
    91501 tcttggttga taccattaag gaagccattc cttttatcct gacagggtct gccatccagc
    91561 tcttccagat tttggatcag ctgaccttta tcaatagtat gagctggttt accaactaca
    91621 gcaatgagga cttggttgtc atgttttctt atttctcagc caatcctaat aaaatcacga
    91681 tgattttgat ttctgtaggg gtttcgattg ggagtgttgg tttgccactt ttgacggaaa
    91741 actatgtcaa gggggacttg aaagcggctt ctcgtctcgt tcaggacagt ctcaccctac
    91801 tctttatgtt cttgctacca gcaacggttg gagtggttat ggtaggagaa cctctttata
    91861 cggtcttcta tggtaagcca gatagtttgg ctctgggctt atttgtcttt gcagttttgc
    91921 agtctattat tttaggcttg tacatggtct tgtctccaat gcttcaggcc atgttccgca
    91981 accgcaaggc cgttctctat tttatctatg gttctattgc caagctagtc ttgcaactac
    92041 ctaccatcgc cctcttccac agttatggtc ctttgatttc aacaaccatt gctctcatca
    92101 ttcctaacgt cttgatgtat cgggatattt gtaaagtaac tggtgtcaag cgcaaggtga
    92161 ttttgaagcg aaccatttta atcagtttgc tgaccctagt catgtttctg ttaataggaa
    92221 ccatccagtg gctgttagga tttttcttcc aaccaagtgg acgtttgtgg agcttctttt
    92281 atgtagctct tgtcggtgcc atggggggtg gactttatat ggttatgagt ctgcgtacct
    92341 atttattaga taaggtaata ggaaaagccc aagcagatcg cctgcgagca aaatttaagc
    92401 tttcgtaagg tagcatttat aaataaaagg aataagttga acaatctttt aggagaactt
    92461 gaaacttatt ccttttttag cgtcaaaata gctaaaatta tctttcaaaa atagaaaatg
    92521 agttttttga ttttttggaa aaaacaattg actaaacaaa ccaagagttg tataataaaa
    92581 taaatattta aagcaggagg ttctggaaat gaaaaagtct aagagcaaat atctaacctt
    92641 ggcaggtttt gtcctgggta caggagtttt attgagcgcg tgtggaaatt ctagcactgc
    92701 atcaaaaacc tataactatg tttattcaag tgatccatct agtttgaact atctagcaga
    92761 aaaccgcgca acaaccaatg atattgtgac caatctggta gatggtctca tggaaaatga
    92821 ccaatatggg aactatgtgc catccttggc agaagattgg actgtttctc aggatggttt
    92881 gacctatacc tacaaacttc gtaaggatgc caagtggttt acttctgagg gagaagaata
    92941 tgcacctgta actgcccagg attttgtgac aggattgcaa tatgcagctg ataaaaaatc
    93001 agaagccttg tatctagtgc aggactctgt tgcaggtttg gatgactata tcactggtaa
    93061 aacaagcgac ttttcaactg tcggtatcaa ggctcttgat gatcaaaccg ttcaatacac
    93121 cttggctcga ccagaacctt actggaactc aaaaacaacc tcaaccattc ttttcccagt
    93181 caatgcagat ttcttgaaat caaaagggga tgattttggc aaggtagacc ctgctaatat
    93241 tttgtacagt ggacctttct tgatgaaagc ttttgtttca aaatctgtca tcgaatacaa
    93301 gaaaaatcct aactactggg atgctaaaaa tgtctttgta gacgatgtga aattgaccta
    93361 ctatgatggt agtgaccaag atgctcttgt tcgtaacttt acagacggag cctatagcta
    93421 tgcccgtctc tatccgaata gttcaagttt tgaagggatt aaagaaaaat acaaagatga
    93481 tatcatctac agtatgcagg atgctacgtc ttattactgg aattttaacc tagatagaca
    93541 agcttataaa tttacttcta agacgaccga cattgaaaag aaatcaactc aggaagcagt
    93601 tcttaataaa aacttccgtc aagctattaa ctttgcctat gatcgtacct cctatggggc
    93661 tcaaactcag ggagaagacg gagcgactaa gattttgcgt aacttggttg ttcctccaac
    93721 ctttgtaagt atcaaaggaa aagattttgg tgaagtagta gcctctaaga tggtcaataa
    93781 ttatggtaag gaatggcaag gcatcaactt tgcggatggt caagaccctt actacaatcc
    93841 tgagaaagcc aaggctaaat ttgctgaggc caagaaagag ctagaagcta agggagttca
    93901 attccctatt catttggatg cgacagttga ccaagcttct aagaagggga ttcaagaagt
    93961 aagctccatg aagcaatcta ttgaagcagc tttaggtacg gagaacgtcg ttattgatat
    94021 ccaacagtta tcaacagagg actatgataa ctcaagttac cttgctcaga ctgctattca
    94081 gaaagactac gacctttaca atggtggttg gagtcctgac tacttagatc catcaaccta
    94141 tcttgatatc tttagtgtca agaatggtgg ggttctacaa aatcttggac tcgaccctgg
    94201 tgaagccaat gacaaggcta aggcagttgg acttgacact tatactcaaa tgttggaaga
    94261 ggctaataag gagcaagacc cagccaaacg ttatgagaaa tatgctgata ttcaagcatg
    94321 gttgatagat agttctctag cgattccaaa tgtttcatta ggtggaacgc ctagcttgag
    94381 aaaaacagtt cctttctcag caccttattc attggctggt aataaagggg ttgaatcata
    94441 taaatacctc aaagtacaag ataagattgt cacaacagac gaatatgcaa aagccagaga
    94501 aaaatggttg aaagaaaaag aagaatccaa taaaaaagcc caagaagaat tggcaaaaca
    94561 tgtcaaataa aatctaattg tagataagtt tgtgtaagaa gtctttgtgc ttaaaaacgc
    94621 ataatatcag gtatataaaa tcctagatgt tatgcgtttt gttataggaa gatttattag
    94681 attttatcct caaattgagt tattcccgac tttatccgtt gaaatattat aaggagtatt
    94741 tatgaaatta aaattattaa gagtagatac taaggtgatt atgtggagtt tcttacttgt
    94801 tctgtctagt ctacttgctt tgttgcttcc ccttatctta aagggtttaa tagatgggag
    94861 ttctattgaa aatataggtt ccaaagtatt tcaatcgttt ttgattttta ttggtcaagc
    94921 cttgttttct tctattggtt actatctgtt tagtcaatcg ggtgaaaaaa gatagcaaaa
    94981 atcaggaaaa aagtgataga ggggttgatt tatgcagaga aatccttctt tgataagagc
    95041 caaagtgggg agttgacttc tgccattgtc aatgacatga gtgtcattcg tgagttttta
    95101 attacgactt tcccaaatat tattctgagt ttagttatgg tacttggttc cattgtagtc
    95161 ttatttagtc ttgattggaa tctttctcta cttttattca tcactcttcc ttgtatgatg
    95221 tttattatct tgcccctttc caatatcagt gaaaagtata gtcgtcgttt acaggaggaa
    95281 atcggatttt taacagggca attgactgaa aagattcaag aacatgaatt aattaagact
    95341 aaccaagcag agaaaagtgt acaggatgtt ttggataatt gtattgaaag ggtacaaaac
    95401 aattcactga aatcagatag ggttacttct tttgagaccc cgtttgctct cttatttatc
    95461 tttgcgacta tagttgtgat gctaacctat gggggttatc gggtcagcgc aggatatata
    95521 tctgtgggaa ccttggtttc gtttttgatt tacctctttc aattacttaa tcctattagt
    95581 aatatagcta attttgtaac tatttattct agtagcaagg gatcttcagt tgcactggag
    95641 aacttgcttg cagttcctaa agaaaaattt gagggaggaa aatcggtatc aggacaaggg
    95701 ttgaatttta accatgtcta ttttggttat gatgaaaatc gacctgtctt aaaggatatt
    95761 acttgttcaa ttttcaaggg gcaaaaaatt gcttttgttg gaccatctgg atcaggaaaa
    95821 tcaacgattg tgcgtttgtt agagcggttt tataaaccgc tttcaggaga tattctaatg
    95881 gagcaatcaa gtatatatga ttttaactta aaagaatgga gaagtaaaat cgcttgggtt
    95941 tcacaaaata atgcagtctt atctggcagt attcgtgaca atctttgtct cggtttgaat
    96001 cgcttagtaa ctgatgatga attgatgaaa gtgctagact tagtatcact aggtgatgag
    96061 attcgctcca tgaaagaggg actagatact gaagttggtg aacgcggacg attcttgtca
    96121 ggggggcaaa gccaaagact tcaaatagct agaacctact taaaagatgc tgaaattctt
    96181 atatttgatg aagccactgc taatcttgat gcggattctg agtatgcgat tatcagtagc
    96241 ctctattctg tattaaagga gaagacggtt gtgattatag cgcatagttt gtcaacggta
    96301 aaagatgtgg attgtatttt cttcttagag gaggggaaaa tcactggctc aggaactcat
    96361 aaggaactac tggaaaatca tgagcgttat gctcgttttg tgcaggagca aatgatagag
    96421 tgaaggtgtc ttttgagatt caccatttta tagtctatta aagggagcag gaaaaactcc
    96481 ctttttatat agtttgaaac tataactagc tcttgaaaag aagaaaatga gttgatgaaa
    96541 ataagtggta caatagttac tatagatttg gaggtattgt atgagcaagg aattacacat
    96601 taacacaatt ttggcccagg cgggtattaa gtcagatgag gcaacaggtg ctttggtgac
    96661 accacttcat ttttcaacga cctatcagca tccagagttt ggtcgatcta ctgggtttga
    96721 ctatacgcgc actaaaaatc caactcgtag taaggctgag gaagtcttgg cggctattga
    96781 gtcagcagac tatgccctag cgactagctc agggatgtca gctattgtac tggcctttag
    96841 cgtctttcca gtaggaagta aggtcttggc agtgcgtgat ctttacggtg gttcttttcg
    96901 ctggtttaac caagtggagc aggaaggtca tttccatttt acctatgcca atacagaaga
    96961 agagttgatt gccgagttag aaaaggatgt ggatgttctc tatatcgaaa ccccaaccaa
    97021 tcccttgatg ttggaatttg atatcgaaaa actagcaaaa ttggctcatg ctaagggtgc
    97081 caaagtggtg gtggacaata ccttctatag ccctatctac caacgtccga ttgaagatgg
    97141 agcagatatc gttctccatt cagcaaccaa gtatctagca ggccacaatg atgtcttggc
    97201 tggagtggtt gtgaccaata gtttagaact atacgagaag cttttttaca atctcaatac
    97261 aacaggggca gtcttgtctc catttgacag ctaccagttg cttcgtggtc tcaagacctt
    97321 atctcttcgt atggagcgct caacagctaa cgcccaagaa gtggttgcct ttttgaagga
    97381 ttctccagca gttaaggaag ttctctacac tggtcgtgga ggcatgattt cctttaaagt
    97441 agccgatgaa acacgcattc ctcatatttt gaacagtctc aaggtcttct cttttgcgga
    97501 aagtttgggc ggagtggaaa gtcttattac ttatccaacg actcaaactc atgctgatat
    97561 tccagcagaa gtacgccatt cttatggttt gacagatgac ctcttgcgtt tgtctattgg
    97621 gattgaggat gctagagatt tgattgcaga tttgcgccaa gccttagaag gataagacaa
    97681 agatgggaaa atatgatttt acaagcctgc ccaaccgttt agggcaccat acctataaat
    97741 ggaaagaaac agaaacggat agtgaagttc taccagcttg gatagcggat atggactttg
    97801 tggtcttgcc tgaaatccgc caagccgtgc aaacttacgc agaccaactg gtttatggtt
    97861 atacctatgc cagtgaagac ttaattaagg aagttcaaaa gtgggaagct acacaatacg
    97921 gttacaactt tgacaaagag gctcttgtct ttatcgaggg tgtggtacca gccatctcaa
    97981 cagctattca aacctttaca aaagaaggcg aggcggtttt aattaacacg cctgtctacc
    98041 caccctttgc tcgcagtgtc aagttgaata atcgtagatt gattactaat tccttagtgg
    98101 aaaaggatag tctgtttgag attgactttg accaacttga aaaggatttg gtggaagagg
    98161 aggttaaact ctatgttctt tgcaaccctc acaatcctgg tggacgtgtt tgggaaaaag
    98221 aagtgttgga gaagattggc caactctgcc aaaaacacgg tgttttgtta gtttcggatg
    98281 agattcacca agatttgacc ctctttggtc acaaacacca gtctttcaat accatcaatc
    98341 ctgccttcaa aaattttgct atcgtcttga gcagtgccac taaaacattt aatattgctg
    98401 gaacaaaaaa ttcctatgca gtcattgaaa atcctaagtt gagactggct ttccagaaac
    98461 gcctgttggc caataatcag catgaaattt caggcttggg ttatttggcg acagaagctg
    98521 cctatcgata cggtaaagat tggctagagg aactcaagca agtctttgaa gaccacatca
    98581 attatgtgat ggatctattt ggaaaagaga ctaaaatcaa ggtcatgaaa ccgcaaggta
    98641 cctacttgat ttggcttgac ttttcagctt atgacctgac tgatgaaaca ttgcaagagt
    98701 tgttgagaaa tgaagccaag gttatcctca accgtggttt ggattttgga gaggaaggaa
    98761 gtctccatgc ccgcatcaat atagctatgc ccaaatctct gttgcaagaa gtctgtcagc
    98821 ggattgtggc tacttttgcc aaacgttaaa aatccagcct tctaggagaa aagtcttcct
    98881 agaaggctat tttcataggc gaaaatatgg tataataaaa agataaggta aaggtgaaaa
    98941 tatggctaaa ttgattccgg ggaaagttcg tatcgaaggt gttgcccttt atgaaactgg
    99001 taaggttgat atcatcaagg aaaagaacaa tcggctctac gctcgcgttg cagaagaaga
    99061 actgcgctat agtttagagg atgatttggt tttttgtgcc tgtgattttt ttcaaaagag
    99121 gggttactgt gtgcatttgg cagcgctaga gcattttctg aaaaatgatg agcgtggtca
    99181 ggaaatcttg tggagtctgg aagaaggtca tgaagaaaaa gaggccgttg aaaccaaggt
    99241 gaccttgggt ggcaagtttt tggatcgaat tttatctcca aaatcagaat gcgcctatga
    99301 gttatcagct gtgggtcagg tggaagcagg aaccaatcat atcttgtgga ctctgagaat
    99361 cggccaaatc aatagccaaa aatactatgt cattcgggat attccacttt ttttaaggat
    99421 tgtcgagcag agaaagtcgt atatgattgg caagatttat gaggagtctc tttcttggga
    99481 agcctttgat gatgccagcc aagaactttt gactttcttg cacggactaa cggaggaagg
    99541 gctggtttca gacctctttt tccaaaacca aggtcggcac ctctttttcc ctctgacctt
    99601 ttttgagcag ggtgtgaatt tactgatggc cttgccccat tttcaatttg accatcaagt
    99661 ggatagctac caaaccctgc tttttcagga tatgcatgct gatgccaatc tatttgcctt
    99721 tacagtaaca gaatactcgg actattttga aatggaaatc agtgagagtc ctagggtcaa
    99781 tgtcttttat cagggagcag tacttttcca taaaggtcag gtttattttt taacagacca
    99841 gcagatgcgt cttctcaagg aaattaaagc gttacctgtg ggtcaacaag gaaagaaata
    99901 cctgcaattt gatagcagtg atcgagacaa attggcctcc tgtctgactc tttttatcca
    99961 gatgggcacc gtttcagctc cagaacgtct acaaatcaaa acttttgcgc cctcttttta
   100021 ctttgacagg gaagaagata atcggattcg tttggaaatt cagtttgatt atggaaatag
   100081 acaggtatct agccgacaag agctagaaga attaccattt tcaagtgacg cagacttaga
   100141 agaaagaatt ttccaagtct gtttggctgc gggctttgaa gccgattttc aatcttggcg
   100201 tcaggcctta aaagcggagt ctgtctatca tttttttcat gatatcattc cagtctttga
   100261 aaaactcggg catgttgacc tatcagataa actagaagag ctttatagcc tagcgagtcc
   100321 tcaggtgcag attgcctcca agggaggtct cttggaaatc cagtttgatt ttcaagatat
   100381 tgcccaggag gaaatcgacc aagccatgca ggccttggtt gccaatcagg atttttatat
   100441 tgattcgtct aatcaagttt actttttcga tgaagaaacc aagaaaattc gccaaaatct
   100501 acaggaactg gggcaatttg aattaaaaga tgggaccttg caggctcgga aatccttggc
   100561 ctacagttta gctcatctct ttgaagggcg agaccgtgtt tctttttcac aagaattcca
   100621 gaatctggcc caggatttga cacatccaga ggactttcct cgacaggcaa ctcaggttca
   100681 ggctgacttg cgagattatc aggaaaaggg aattggctgg ttgcagatgc tccatcatta
   100741 tggttttggt gggattttgg ctgatgatat gggacttggg aaaacccttc agaccattgc
   100801 ttttttgact agtcaagtga caaaagaaag tcgggttttg attctcgctc cgtcaggttt
   100861 gatttacaac tgggcagatg agtttcagaa atttgcccca cagttggatg tggctgttgt
   100921 tcatggtttg aaagcaagtc gtgaggagat tcttgccgag agccatcaaa tctatgtgac
   100981 tagctatgcc accttccgtc aggacagtga gttttatcag gggatggcct ttgacttcct
   101041 tttcttagat gaggctcagg tcatgaaaaa tgcccagacc aagattgccc agaccttgag
   101101 acaatttgtg gtgccgtcgg tctttgcctt gtcaggaact ccgattgaaa accatctggg
   101161 tgagttgtgg tctattttcc aaatcgtcat gcccggactt ttgccaagca agaaagaatt
   101221 tatgaaattg ccagcagagc gagtggctca gtttatcaag cctttcgtga tgcgacgcaa
   101281 gaaagaagaa gttctgactg aattgccaga cttgattgag gtggtttata aaaatgaact
   101341 ggaagaccag caaaaggcta tttaccttgc ccagttacaa cagatgcgag accatctggc
   101401 tcaagtgtca gaacaggaat ttcagcgaag tcgtgtggaa attttatctg gtttgatgcg
   101461 cttgcgtcaa atatgtgaca ctcctgccct gtttatggaa gattatcagg gagccagcgg
   101521 caaactagat agtctccgag acctactggt acaggtggca gacggcggac accgtgtctt
   101581 gattttctct cagttcaagg gaatgttgga aaaaattgaa caagaactgc cagacttggg
   101641 cctgacatcc tttaaaatta cgggttcaac cccagccaag gaaagacaag acatgaccaa
   101701 ggcctttaac caaggagaaa gagatgcctt tctgatttcc ctcaaggctg gtggggtcgg
   101761 tctgaacctg acaggtgcag atacagtgat cttggttgac ctttggtgga atcctgcggt
   101821 ggaagcgcaa gccattggcc gtgcccatcg gatgggtcag gaagaaacgg ttgaggtcta
   101881 tcgcttggtg accaagggaa ccattgaaga aaaaattcag gaactccaag aacaaaagaa
   101941 acatctggtg tcacaagtat tggatggcac agagtcacgt ggtagtctga ccctagcaga
   102001 aattagagaa attttgggaa tttctgaagc cagcacttga aaaatcaaga caatacgcta
   102061 taatgaagtg ttgaaaggaa atagaaaatg aaacaagaac gatttccatt ggtgtcagat
   102121 gacgaggtca tgttgactga aatgccagtc atgaatctct atgatgagtc tgatctgatc
   102181 agtaatatca agggtgagta tcgagataaa aattatttag aatgggctcc tattactgaa
   102241 gaaaaaccag taaaaccgat tgaaaagcaa gtcgaaaaac ctaaaaaggc tcctttaggg
   102301 gttaaaaaag aaggaaagag ctatgcggag gtggcgcgtg aagaagcgcg tgcggacttg
   102361 aaaaagaaac gctctgctaa ctacctaact caggatttca gccttgcgag acgtcattct
   102421 cagcccagtc tagttagaca gggcaatcaa ccgacaactc ctttccaaaa ggaaaatcct
   102481 ggtgaatttg tcaaatatag ccaaaaattg acccagtctc attatatctt ggcggaagaa
   102541 gttcattcta tccctaccaa gaatgaagaa gtgtcagcac ctgctccaaa gaaaaacaat
   102601 tatgattttc taaagaagag ccaaatctac aataaaaaaa gtaaacaaac agaacaagaa
   102661 cgtcgggttg cccaagagtt gaatctgacc agaatgacag aataggggag aaaacatgtc
   102721 aaagacatat cattttatcg gaattaaggg atcagggatg agtgccttgg ccttgatgtt
   102781 gcaccagatg gggcacaagg ttcagggatc agatgttgaa aagtactact ttacccaacg
   102841 cggtcttgag caggcaggaa ttaccattct tccttttgat gaaaagaatc tagacggtga
   102901 tatggaaatt atcgctggaa atgcctttcg tccagataac aacgtcgaaa ttgtctatgc
   102961 ggaccaaaat ggtatcagct acaaacgtta ccatgagttt ctaggtagct ttatgcgtga
   103021 ctttgttagc atgggagtag caggagcaca tggaaaaact tcaacgacag gtatgttgtc
   103081 tcatgtcttg tctcacatta cagataccag cttcttgatt ggagatggga caggtcgtgg
   103141 ttcggccaat gccaaatatt ttgtctttga atctgacgaa tatgagcgtc acttcatgcc
   103201 ttaccaccca gaatactcta ttatcaccaa cattgacttt gaccatccag attatttcac
   103261 aagtctcgag gatgttttca atgcctttaa cgactatgcc aaacaaatca ccaagggtct
   103321 ttttgtctat ggtgaagatg ctgaattgcg taagattacg tctgatgcac caatttatta
   103381 ttatggtttt gaagctgaag gcaatgactt tgtagctagt gatcttcttc gttcaacaac
   103441 tggttcaacc ttcaccgttc atttccgtgg acaaaacttg gggcaattcc acattccaac
   103501 ctttggtcgt cacaatatca tgaatgcgac agccgttatt ggtcttcttt acacagcagg
   103561 atttgatttg aacttggtgc gtgagcactt gaaaacattt tccggtgtta aacgtcgttt
   103621 cactgagaaa attgtcaatg atacagtgat tatcgatgac tttgcccatc atccaacaga
   103681 aattattgcg accttggatg cggctcgtca gaaataccca agcaaggaaa ttgtagcagt
   103741 ctttcaaccg cataccttta caagaaccat tgccttgttg gacgactttg cccatgcttt
   103801 aaaccaagca gatgctgttt atctagcgca aatttatggc tcggctcgtg aagtagatca
   103861 tggtgacgtt aaggtagaag acctagccaa caaaatcaac aaaaaacacc aagtgattac
   103921 tgttgaaaat gtttctccac tcctagacca tgacaatgct gtttacgtct ttatgggagc
   103981 aggagacatc caaacctatg aatactcatt tgagcgtctc ttgtctaact tgacaagcaa
   104041 tgttcaatag gatgttccca tggaaattcc aattaagatc attcaggcaa gcaagtctga
   104101 tttgcctgag ataggggcac ttcagacctc gtcttttcca gctgaaaagc agcaactttc
   104161 ccatatttta gaagaaagta tccgtaagtg tgcggatacc tttcttctag ctagggatga
   104221 aaatcaactt ttaggctata ttttatcaag tccccagtca gacaatccgc aatatctaaa
   104281 agtacattct ttagtcatcg agtctgacca tcagagacag ggcttgggaa cacttcttct
   104341 tgcagccttg aaagaggtgg cagttgagct ggattacaaa gggattcgtt tggagagtcc
   104401 tgatgagctg ctttcctatt ttgaaatgaa cggttttgtt gatgaagaag caactttgct
   104461 ctatgcaact agccagggct atagtatgat ttggtttaat cccttttatc tggaggaaca
   104521 atgaaaatca gacaagcaag attagaagat ttggatcgga ttgttgaact tgaatttgaa
   104581 aatttttcgg tcgaagaagc cattcctcct tctgtctttg aagcacattt gagagaaatt
   104641 cagacctctt ttctggttgc tgaaaaagaa ggaagaatca tgggttatat cgaaggacca
   104701 gttggcctgc accgccatct gcaagaccag tcttttacag aagaaataaa agactatagt
   104761 catgagcctg gtggttatat ctctgtgacc tgtctgtcta ttgccaagga ggcacaggga
   104821 ctcggactgg gtcagaaatt gctgacagcc ttgaaagaag ttgctcttga agatgagaga
   104881 gatggcatta atctaacctg tcatgactat ctcatcgcct actatgaaaa acatggattt
   104941 gtcaacgaag gccagtccca gtcaaccttt gcaggggaaa catggtatga tatggtctgg
   105001 gaaatgaaaa aataagttag gaaaagtatc atagattgct ttttttggac ttttaagata
   105061 taatattatg gattatcaac aaggaggaaa aacttttgag tgaaaagtca agagaagaag
   105121 agaaattaag ctttaaagag cagattctga gagatttaga aaaagtaaaa ggctatgatg
   105181 aagttctgaa agaagatgag gcagtagttc gcactcctgc aaatgaacct tcaactgaag
   105241 aactcatggc tgattccttg tcaacggtag aggagattat gagaaaagct cctaccgtgc
   105301 ctactcaccc aagtcaaggt gtaccagctt ctccagcaga tgagattcaa agagaaactc
   105361 ctggtgttcc aagtcatcca agtcaagatg taccttcttc tccagcggaa gaaagtggat
   105421 caagaccagg tccaggtcct gttagaccta agaaacttga aagagaatac aatgaaaccc
   105481 caacaagggt agctgtttcc tatacgacgg cagagaaaaa agcagaacaa gcaggtccag
   105541 aaacacctac gcctgctaca gaaacagtgg atatcatcag agatacatca cgtcgtagcc
   105601 gtagagaagg agcaaaaccc gttaagccta agaaagagaa gaagtcacat gtgaaagctt
   105661 ttgtgatttc attccttgta ttccttgcct tgctctcagc aggtggttac tttggttacc
   105721 agtacgtgct agattcctta ttacctatcg atgctaattc taagaaatat gtgacggttg
   105781 gaattccaga aggttcaaac gttcaagaaa tcggtacgac gcttgaaaaa gctggtttgg
   105841 taaagcatgg tctgattttt agtttttatg ccaagtataa aaattatacc gacttgaaag
   105901 caggttacta caatttgcaa aagagtatga gtacagaaga cttactcaaa gagttgcaaa
   105961 aaggtggaac agatgaaccg caagaacctg tacttgcgac tttgacaatt ccagaaggtt
   106021 ataccttgga tcagattgct caagctgtgg gtcaattgca aggtgacttc aaagagtctt
   106081 tgacagcgga gactttcttg gctaaagttc aagatgagac gtttatcagt caagcagtag
   106141 cgaaatatcc tactttactg gaaagtttgc ctgtaaaaga cagcggtgcg cgttatcgtt
   106201 tggaaggata ccttttccca gctacatact ctatcaagga aagcacaact attgagagct
   106261 tgattgatga gatgttagct gctatggata agaacctatc tccttactat agtactatca
   106321 aatctaaaaa cttgactgtc aatgagttgt tgaccattgc ttccttggtc gaaaaagaag
   106381 gtgccaagac agaagatcgt aagctcattg caggtgtatt ctacaatcgt ttgaatcgtg
   106441 atatgccact tcaaagtaat attgcaatct tgtatgccca aggaaaactg gggcaaaata
   106501 tcagtctagc tgaggatgtt gcgattgata ccaacattga ttcaccttat aatgtttata
   106561 aaaatgtagg tctcatgcct ggtccagtcg atagtccaag tctggatgcg attgagtcaa
   106621 gcatcaatca aactaagagc gataacctct actttgtagc agatgtcaca gaaggcaagg
   106681 tctactatgc taacaatcaa gaagaccacg accgcaatgt cgctgaacat gtcaacagca
   106741 aattaaacta aacaaactaa aattatgtta tacttcacat aattttcttt agaaaatatt
   106801 atcagaagaa agttgagaaa aatggcagaa aaaacatatc ctatgaccct tgaggaaaag
   106861 gaaaaacttg aaaaagaatt agaagaattg aaattggttc gtcgaccaga agtggtagaa
   106921 cgcattaaga ttgcccgttc atacggtgac ctttcagaaa acagtgagta cgaagcagct
   106981 aaggatgaac aagcctttgt cgaaggacaa atctctagct tagaaacaaa aatccgctat
   107041 gctgaaatcg tcaatagcga cgcagttgcc caggacgaag tagcgattgg taaaacagtc
   107101 accatccaag aaattggtga ggacgaagaa gaagtttata ttatcgtagg ttcagctggt
   107161 gcggatgcct ttgcaggtaa ggtttcaaat gaaagcccaa ttgggcaggc cttgattggc
   107221 aagaaaacag gtgatacagc aaccattgaa acgcctgttg gtagctatga tgtaaaaatc
   107281 ttgaaggttg aaaaaacagc ctaaaaacag aaaaaggagt ggggaggcga tgtgcttcac
   107341 tcactccttt ttccattttg ctattcttcg aaaatctctt caaaccacgt cagcgtcgcc
   107401 ttgccgtatg tatggttact gacttcgtca gtttcatcta caacctcaaa acagtgtttt
   107461 gagcaacctg cggctagttt cctagtttgc tctttgattt ttattgagta ttagatgtat
   107521 agtgcattga agttaaaata gtacactttg atttctaaga cattgttaga aattagatta
   107581 aattccttaa tcgatttgcg catgttttat ttcatttcac tatactttag attggaaaat
   107641 aaggaatcac ataaatcgca agaaataggg aatctgattc gtgtttataa ccgttcaaaa
   107701 agagaagagg ctgaaagtga gccacttaat ctttatgtcg aagatgaaaa gggcaatctc
   107761 ctggcaggtt tgatagcaga gacttttgga aattggctag aaatcgagta tttgtttgta
   107821 aaagaggaac tgcgagggca aggaatcggt tcaaaactat tgcaacaggc agaaagtgaa
   107881 gctaagaatc gaaattgttg ttttgccttt gtcaatactt accagttcca ggcaccggac
   107941 ttttatcaga aacatggcta caaggaagtt ttttctttgc aagactatct ctacattagg
   108001 caaagatatt attaccaaaa gaatctgtaa ggtgagtatg gaggtataat acaaagagag
   108061 gctcgcacat aagtatggag gtggactgat gtatatgagt aactatcgat aaataccagt
   108121 tataacctag aaattgtgtc tttctagacg atattgagga caatataatc gtagccccaa
   108181 aattaggaat caagacttat caggttaaga aaagaagtga tgttgttgat attttaaaca
   108241 atttatttaa actaaaaact ctctatctat taatccgaga ttcccctctc ggattttgtg
   108301 ttgctttcat taaatttaca ggtaagactt gctagcttca gtaaatatac acaagttttt
   108361 cagaatagag tgaaatccaa aagaaaatgg aaataatgaa agctcttgta agcataagaa
   108421 aacacctctg tgttatactt gttgttcaac cacaaacaca agaaaggcac agagatgcaa
   108481 gacaattata ctacaaaagc caaacatttg acaatcgata gccgtcgctt aatcgaaaga
   108541 tggaaaaaag aagggaaatc aaatagagaa attgcctctc tgcttggaaa agttcctcaa
   108601 actatccaca ctgaaatcaa gcgtgggaca gtccgacaat gtcttggaaa agggcgcttc
   108661 aaagaggttt attctgccga ctatgctcaa cagtcttatg aaaataatcg caagcgctcg
   108721 gtcaagaaat caagcttgac caaggaacta aaggaaaaga ttctccacta tcataaccaa
   108781 aaattttcgc ctgaaatgat ggtgatggct aaaggggtta acgtgggaat ttcaaccatt
   108841 tactattgga ttcatcatgg aaaattgggg ttaagcaaac aggatctgct ttaccctaga
   108901 aaaggaaaag cgc
//
LOCUS       DAVHIZ010000002        65829 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.002, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000002 DAVHIZ010000000
VERSION     DAVHIZ010000002.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 65829)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 65829)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..65829
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.002"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            6..2036
                     /locus_tag="VVO18_000111"
     CDS             6..2036
                     /locus_tag="VVO18_000111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000460919.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEU5585341.1"
                     /translation="MFDYRALVILMTLMDHCELSLYELSVKVSLPIKEVKEGIDYLVP
                     YLANKGIVLDKKQGRYSLSNRTKQSLTDIIKSDELVLPKSTRLALIYLYTFCRLDFIS
                     NNHYQDFLKVSKNTTLSDIQSLRKIMLDNDLELGYSRAKGYTLHGSEWNKHRLAFQMV
                     SELLESSIGIWGLDYVLSSWGYSLTYDLIDQVVKDYYEKLQLVPIVNQLKVYLFGLVF
                     ILCRYQRDVERVCLSETLVSPVIQDITTILLDTVVDLGIIDTVFSEDDYRYITVLLSS
                     CFEGEVDVAPVYFNQLTEAIISRMEDISLLHFKQREGLRENLRRHLIPAYYRLKFGLP
                     SSNEYVLHVKEHYPDLFELVKDSLMPLMDAIDNPIPDSETAYFVIHFGGYLKKADTLP
                     QKWYKAAIICPNGVSSSLMLKENLLALFPQIEFIGTSKIDDLQVKASSDYDMVFSTIK
                     VETEKPNYLVSVMMTEEQAIQLVELVLKDFPNLEYGDFEIEQILNIVKRYGIITQELE
                     LRLALKNYLYQKNDRKEIVPVLEQLITKETYQVSSQKLGWKEAIRLAAKPLLDQDKIT
                     ENYPEAMIQKVEEFGPFINLGKGVAIPHARPDEGVNEIGMSMLVLEEPIYLLDNPEQE
                     VRLLICIAAIDNESHLKALSHLTTILRDKNHVQTLISSKNYDDIKMIIKQED"
     gene            2040..2324
                     /locus_tag="VVO18_000112"
     CDS             2040..2324
                     /locus_tag="VVO18_000112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008089859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5585342.1"
                     /translation="MLKIGTACGSGLGSSFMVQMNIESVLSDLNVSDVEVEHYDLGGA
                     DPNAADIWIVGRDLADSASHLGDVRILNSIIDMDELRELITKLCEEKGLI"
     gene            2337..3683
                     /locus_tag="VVO18_000113"
     CDS             2337..3683
                     /locus_tag="VVO18_000113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000975284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU5585343.1"
                     /translation="MMKFILDIVSTPAILVALIAILGLVLQKKKLPDIIKGGIKTFVG
                     FLVVSGGAGIVQNSLNPFGTMFEHAFHLSGVVPNNEAIVAVALTTYGSATALIMFAGM
                     VFNILIARFTRFKYIFLTGHHTLYMACMIAVILSVAGFTSLPLILLGGLALGIIMSIS
                     PAFVQKYMVQLTGNDKVALGHFSSLGYWLSGFTGSLIGDKSKSTEDIKFPKSLAFLRD
                     STVSITLSMAVIYIIVAIFAGSEYIEKEISSGTSGLVYALQLAGQFAAGVFVILAGVR
                     LILGEIVPAFKGISERLVPNSKPALDCPIVYTYAPNAVLIGFISSFIGGLVSMAIMIA
                     SGTVVILPGVVPHFFCGATAGVIGNASGGVRGATIGAFLQGILISFLPVFLMPVLGGL
                     GFQGSTFSDADFGLSGIILGMLNQFGSQAGIVIGLVLILAVMFGVSFIKKPSAKEE"
     gene            3687..4544
                     /locus_tag="VVO18_000114"
     CDS             3687..4544
                     /locus_tag="VVO18_000114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEU5585344.1"
                     /translation="MILSKNREDELRKFATNIRLNTLRTLNHLGFGHYGGSLSIVEVL
                     AVLYGEIMPMTPEIFAARDRDYFILSKGHGGPALYSTLYLNGFFDKEFLYSLNTNGTK
                     LPSHPDRNLTPGIDMTTGSLGQGISVATGLAYGQRIRKSPFYTYAIVGDGELNEGQCW
                     EAIQFASHQQLSNLIVFVDDNKKQLDGFTKDICNPGDFVEKFSAFGFESIRVKGSDIR
                     EIYEGIVQLKQSNNSSPKCIVLDTIKGQGVQELEEMKSNHHLRPTVEEKQMLTSVVER
                     LSQELEETE"
     gene            4541..5473
                     /locus_tag="VVO18_000115"
     CDS             4541..5473
                     /locus_tag="VVO18_000115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase family protein"
                     /protein_id="HEU5585345.1"
                     /translation="MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEK
                     DFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFSSRRVFDQLFISLGYAQLDA
                     TVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
                     YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSV
                     GVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQ
                     ERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR"
     gene            5706..7409
                     /gene="ilvD"
                     /locus_tag="VVO18_000116"
     CDS             5706..7409
                     /gene="ilvD"
                     /locus_tag="VVO18_000116"
                     /EC_number="4.2.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="HEU5585346.1"
                     /translation="MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVIS
                     TWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDI
                     IADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
                     IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLP
                     GSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNA
                     TLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLL
                     ANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDG
                     AVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEML
                     SLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQ
                     DTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGK
                     K"
     gene            complement(7570..7650)
                     /locus_tag="VVO18_000117"
                     /pseudo
     CDS             complement(7570..7650)
                     /locus_tag="VVO18_000117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(7708..8049)
                     /locus_tag="VVO18_000118"
     CDS             complement(7708..8049)
                     /locus_tag="VVO18_000118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003080443.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEU5585347.1"
                     /translation="MRDDIKINDRALALQDQIIEKLEKVFDTDVELDVYNLGLIYEIN
                     LDETGLCKIVMTFTDTACDCAESLPIEIVAGLKQIEGIKDIKVEVTWSPAWKITRISR
                     YGRIALGLPPR"
     gene            8173..9024
                     /gene="rgg"
                     /locus_tag="VVO18_000119"
                     /pseudo
     CDS             8173..9024
                     /gene="rgg"
                     /locus_tag="VVO18_000119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434947.1"
                     /note="Rgg, as the term is used in Streptococcus
                     pneumoniae, is the lone quorum-sensing system
                     transcriptional regulator related to proteins Rgg1, Rgg2,
                     Rgg3, and Rgg4 of Streptococcus pyogenes.; internal stop;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system transcriptional regulator
                     Rgg"
     gene            9215..10462
                     /locus_tag="VVO18_000120"
     CDS             9215..10462
                     /locus_tag="VVO18_000120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter"
                     /protein_id="HEU5585348.1"
                     /translation="MKLLFRNPAYRILTLSRFFNAFGASIFNLVFIVYASTLSQASFA
                     VAMANIVMILPTLFTVFAGIRADYTRDKVKWMVYSGLFQAVLFFLAALVVQQASLFAF
                     SSLCLINVISDIISDFAGGLRMPLIKEKVAEDDLMEAYSFSQFITYISAIGGQAFGVW
                     LLALSVNNFSLVAGINACFFLVSATILFLGKSKLSLSMSSADGENLKNEKLSIKDQFL
                     TIYRNLRLVFLKSGQKNFGFMLFAVLLINSLGGALGGIYNIFFLSHSLLNFSYTEALF
                     INQFCVLVAIIISSLTGNDYFGKQSLPRLMMWATVGLSLVGLANLFNQVVLGLLFLFF
                     TLYVSGKVQPKISAMLMKNLAPEVLARTSNFFGLLFTLSIPVGTACFSLVAVWNMQLT
                     WMLFVGFSLLAIFLTILNLKNDI"
     gene            10539..11828
                     /locus_tag="VVO18_000121"
     CDS             10539..11828
                     /locus_tag="VVO18_000121"
                     /EC_number="6.1.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine--tRNA ligase"
                     /protein_id="HEU5585349.1"
                     /translation="MKLQKPKGTQDILPAESAKWQYVEGFAREIFKRYNYAEVRTPIF
                     EHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQK
                     PSKFYYMGPMFRYERPQAGRLRQFHQIGVECFGSSNPATDVETIAMAAHFLKEIGIQG
                     VKLHLNTLGNPESRAAYRQALIDYLTPLKETLSKDSQRRLEENPLRVLDSKEKEDKVA
                     VENAPSILDFLDEESQTHFDAVRQMLENLGVDYIIDTNMVRGLDYYNHTIFEFITEIE
                     GNDLTVCAGGRYDGLVAYFGGPETAGFGFGLGVERLLLILEKQGVALPIENALDVYIA
                     VLGDGANVKALELVQALRQQGFKAERDYLNRKLKAQFKSADVFAAKTLITLGESEVES
                     GQVTVKNNQTREEVQVSLETISQNFSEIFEKLGFYTQ"
     gene            11825..11902
                     /locus_tag="VVO18_000122"
                     /pseudo
     CDS             11825..11902
                     /locus_tag="VVO18_000122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            12170..12484
                     /locus_tag="VVO18_000123"
     CDS             12170..12484
                     /locus_tag="VVO18_000123"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585350.1"
                     /translation="MWVLGFILFMIFFYSNNSKKIKKLENKIKKLERKEKGNAEMSRL
                     LQEMIGKEPIITGVYIGPDNWEVVDVDEEWVKLRSVDNTGKEKFKLQRIEDIQTVEFD
                     GE"
     gene            12494..12700
                     /locus_tag="VVO18_000124"
     CDS             12494..12700
                     /locus_tag="VVO18_000124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001176227.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5585351.1"
                     /translation="MQLKNRLKELRARDGLNQTDLAKLAGVSRQTISLLERDEYTPSI
                     IIALKISQIFNETVESVFRLEEDE"
     gene            12700..12897
                     /locus_tag="VVO18_000125"
     CDS             12700..12897
                     /locus_tag="VVO18_000125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001046145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585352.1"
                     /translation="MNKYKVIYYVVVIALLVSVFLLIGMDLSWFNPYQSDQFVWVYFA
                     LIPVTEWIEKKSKNLASEKGE"
     gene            12900..13634
                     /locus_tag="VVO18_000126"
     CDS             12900..13634
                     /locus_tag="VVO18_000126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3169 family protein"
                     /protein_id="HEU5585353.1"
                     /translation="MKKKRRLLFLMSIVLGGVLGMFVGMFKARVESHEIILDVKALMP
                     WISAICLLIGFISMFLTFNFLKKSRKFHSLYQEEMDDDLNETYYVQMYRNLEFGTIAF
                     NITGVAIPLAIFISLSEVIILHTNPQTFFLSFLLFVVFLVAQKSLFKTIAIVRQFDLE
                     FFATPKDVLNYINSYDEGERQANLEQSFRILFQLHQYVLPALYIFLIIISFLTGEIQL
                     LAFLLVGAIHVYINVMQLPMVKRYFK"
     gene            13646..14287
                     /locus_tag="VVO18_000127"
     CDS             13646..14287
                     /locus_tag="VVO18_000127"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5585354.1"
                     /translation="MKLLKNLGWILLALLSFFFIYGFIQGLATASLALGASPYAVTLL
                     YVVLAGVYVYGIYKWYQKAPVYIEKSGFNRFIWLPALVWFLSLVVQFFLPDDPSVNQQ
                     IATDLTLSQPLFSFFAVVIFAPLTEEIVFRGMLARYLFPKQDNSKRTLIFLLVSSLLF
                     ALIHFPGDVQQFFVYFSLGFSLGLAYVSRKGLVYSISLHALNNLVGFLMILML"
     gene            14305..14535
                     /locus_tag="VVO18_000128"
     CDS             14305..14535
                     /locus_tag="VVO18_000128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000832182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585355.1"
                     /translation="MKRVILLAVIQAVVLFFIIGALAYAFKGDFFYNYLAVVFAPIAG
                     VLRFGTAYITEIVLPRKAAEIAEKRKAGKNSK"
     gene            14571..14651
                     /locus_tag="VVO18_000129"
                     /pseudo
     CDS             14571..14651
                     /locus_tag="VVO18_000129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            14932..16695
                     /gene="aspS"
                     /locus_tag="VVO18_000130"
     CDS             14932..16695
                     /gene="aspS"
                     /locus_tag="VVO18_000130"
                     /EC_number="6.1.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830881.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--tRNA ligase"
                     /protein_id="HEU5585356.1"
                     /translation="MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREG
                     IMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIV
                     LNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEF
                     IDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKC
                     FRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRMKY
                     DDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEAPAVKAIVVKGAADNYSRKDI
                     DKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADT
                     LEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQ
                     EETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQ
                     FGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTV
                     ALKQLEELSLQVEEDETSKTN"
     gene            16673..17614
                     /locus_tag="VVO18_000131"
     CDS             16673..17614
                     /locus_tag="VVO18_000131"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEU5585357.1"
                     /translation="MKQAKRIKRWRYYLRRFAYQIKILRVLQSISREKYDEKISASLV
                     YGFLSAVAVNFFFQPGHVYSSGATGLAQIISALSNHWFGFHIPISLSFYAINFPLMVL
                     AWYQIGHKFTVFTFITVSMSSFFIQFVPVATLTEDPIINSLFGGVVMGLGIGFALRNN
                     ISSGGTDIVSLTIRKKTGKNVGSISFLVNGTIMLIAGLTFGWKYALYSMITIFVSSRV
                     TDAVFTKQKRMQAMIVTNHPEKVIEKIHKKLHRGATMIHDAEGTYNHERKAVLITVIT
                     RAEFNEFKQIMTQVDPSSFVSVSENVHILGRFVEIDN"
     gene            complement(17650..17838)
                     /locus_tag="VVO18_000132"
     CDS             complement(17650..17838)
                     /locus_tag="VVO18_000132"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585358.1"
                     /translation="MRFIVGRFTSFSTEIESFPKIFLYSMKIKVQTRKLAAGCSKHGF
                     EVADRTDEVSNIYTARRR"
     gene            complement(17905..18891)
                     /locus_tag="VVO18_000133"
     CDS             complement(17905..18891)
                     /locus_tag="VVO18_000133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5585359.1"
                     /translation="MPVTIKDVAKAAGVSPSTVTRVIQNKSTISDETKKRVRKAMKEL
                     NYHPNLNARSLVSSYTQVIGLVLPDDSDAFYQNPFFPSVLRGISQVASENHYAIQIAT
                     GKDEKERLNAISQMVYGKRVDGLIFLYAQEEDPLVKLVAEEQFPFLILGKSLSPFIPL
                     VDNDNVQAGFDATEYFIKKGCKRIAFIGGSKKLFVTKDRLTGYEQALKHYKLTTDNNR
                     IYFADEFLEEKGYKFSKRLFKHDPQIDAIITTDSLLAEGVCNYIAKHQLDVPVLSFDS
                     VNPKLNLAAYVDINSLELGRVSLETILQIINDNKNNKQICYRQLIAHKIIEK"
     gene            complement(18901..19701)
                     /locus_tag="VVO18_000134"
     CDS             complement(18901..19701)
                     /locus_tag="VVO18_000134"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000938258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1189 domain-containing protein"
                     /protein_id="HEU5585360.1"
                     /translation="MLPYPFSYFSSIWGFRKPLSKRFELNWFQLLFTSIFLISLSMVP
                     IAIQNSSQETYPLETFIDNVYEPLTNEVVQDLSEHATIVDGTLTYTGTASQTPSVVIG
                     PSQIKELPKDLQLHFDTNELVISKESKELTRISYRAIQTESFKSKDSLTQAISKDWYQ
                     QNRVYISLFLVLGASFLFGLNFFIVSLGASLLLYITKKSRLFSFRTFKECYHFILNCL
                     GLPTLITLILGLFGQNMTTLITVQNILFVLYLVTIFYKTHFRDPNYHK"
     gene            complement(19954..20796)
                     /locus_tag="VVO18_000135"
     CDS             complement(19954..20796)
                     /locus_tag="VVO18_000135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001065636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5585361.1"
                     /translation="MNNSIKLKRRLTQSLTYLYLIGLSIVIIYPLLITIMSAFKAGNV
                     SAFKLDTNIDLNFDNFKGLFTETLYGTWYLNTLIIALITMAVQTSIIVLAGYAYSRYN
                     FLARKQSLVFFLIIQMVPTMAALTAFFVMALMLNALNHSWFLIFLYVGGGIPMNAWLM
                     KGYFDTVPMSLDESAKLDGAGHFRRFWQIVLPLVRPMVAVQALWAFMGPFGDYILSSF
                     LLREKEYFTVAVGLQTFVNNAKNLKIAYFSAGAILIALPICILFFFLQKNFVSGLTSG
                     GDKG"
     gene            complement(20798..22090)
                     /locus_tag="VVO18_000136"
     CDS             complement(20798..22090)
                     /locus_tag="VVO18_000136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000414940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5585362.1"
                     /translation="MEKQQPSKAALLSIIPGLGQIYNKQKAKGFIFLGVTIVFVLYFL
                     ALATPELSNLITLGDKPGRDNSLFMLIRGAFHLIFVIVYVLFYFSNIKDAHTIAKRIN
                     NGIPVPRTLKDMIKGIYENGFPYLLIIPSYVAMTFAIIFPVIVTLMIAFTNYDFQHLP
                     PNKLLDWVGLTNFTNIWSLSTFRSAFGSVLSWTIIWALAASTLQIVIGIFTAIIANQP
                     FIKGKRIFGVIFLLPWAVPAFITILTFSNMFNDSVGAINTQVLPILAKFLPFLDGALI
                     PWKTDPTWTKIALIMMQGWLGFPYIYVLTLGILQSIPNDLYEAAYIDGANAWQKFRNI
                     TFPMILAVAAPTLISQYTFNFNNFSIMYLFNGGGPGSVGGGAGSTDILISWIYRLTTG
                     TSPQYSMAAAVTLIISIIVISISMIAFKKLHAFDMEDV"
     gene            complement(22201..23472)
                     /locus_tag="VVO18_000137"
     CDS             complement(22201..23472)
                     /locus_tag="VVO18_000137"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000095461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU5585363.1"
                     /translation="MSSKFMKSTAVLGTATLASLLLVACGSKTADKPADSGSSEVKEL
                     TVYVDEGYKSYIEEVAKAYEKEAGVKVTLKTGDALGGLDKLSLDNQSGNVPDVMMAPY
                     DRVGSLGSDGQLSEVKLSDGAKTDDTTKSLVTAANGKVYGAPAVIESLVMYYNKDLVK
                     DAPKTFADLENLAKDSKYAFAGEDGKTTAFLADWTNFYYTYGLLAGNGAYVFGQNGKD
                     AKDIGLANDGSIAGINYAKSWYEKWPKGMQDTEGAGNLIQTQFQEGKTAAIIDGPWKA
                     QAFKDAKVNYGVATIPTLPNGKEYAAFGGGKAWVIPQAVKNLEASQKFVDFLVATEQQ
                     KVLYDKTNEIPANTEARSYAEGKNDELTTAVIKQFKNTQPLPNISQMSAVWDPAKNML
                     FDAVSGQKDAKTAANDAVTLIKETIKQKFGE"
     gene            24022..25539
                     /gene="malQ"
                     /locus_tag="VVO18_000138"
     CDS             24022..25539
                     /gene="malQ"
                     /locus_tag="VVO18_000138"
                     /EC_number="2.4.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-alpha-glucanotransferase"
                     /protein_id="HEU5585364.1"
                     /translation="MKKRQSGVLMHISSLPGAYGIGSFGQSAYDFVDFLVRTKQRYWQ
                     ILPLGATSYGDSPYQSFSAFAGNTHFIDLDILVEQGLLEASDLEGVDFGSDASEVDYA
                     KIYYARRPLLEKAVKRFFEVGDVKDFEKFAQDNQSWLELFAEYMAIKEYFDNLAWTEW
                     PDADARARKASALESYREQLADKLVYHRVTQYFFFQQWLKLKAYANDNHIEIVGDMPI
                     YVAEDSSDMWANPHLFKTDVNGKATCIAGCPPDEFSVTGQLWGNPIYDWEAMDKDGYK
                     WWIERLRESFKIYDIVRIDHFRGFESYWEIPAGSDTAAPGEWVKGPGYKLFAAVKEEL
                     GELNIIAEDLGFMTDEVIELRERTGFPGMKILQFAFNPEDESIDSPHLAPANSVMYTG
                     THDNNTVLGWYRNEIDDATREYMARYTNRKEYETVVHAMLRTVFSSVSFMAIATMQDL
                     LELDEAARMNFPSTLGGNWSWRMTEDQLTPAVEEGLLDLTTIYRRINENLVDLKK"
     gene            25565..27823
                     /gene="glgP"
                     /locus_tag="VVO18_000139"
     CDS             25565..27823
                     /gene="glgP"
                     /locus_tag="VVO18_000139"
                     /EC_number="2.4.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000950172.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen/starch/alpha-glucan family
                     phosphorylase"
                     /protein_id="HEU5585365.1"
                     /translation="MLSLQEFVQNRYNKTIAECSNEELYLALLNYSKLASSQKPVNTG
                     KKKVYYISAEFLIGKLLSNNLINLGLYDDVKKELAAAGKDLIEVEEVELEPSLGNGGL
                     GRLAACFIDSIATLGLNGDGVGLNYHFGLFQQVLKNNQQETIPNAWLTEQNWLVRSSR
                     SYQVPFADFTLTSTLYDIDVTGYETATKNRLRLFDLDSVDSSIIKDGINFDKTDIARN
                     LTLFLYPDDSDRQGELLRIFQQYFMVSNGAQLIIDEAIEKGSNLHDLADYAVVQINDT
                     HPSMVIPELIRLLTARGIELDEAISIVRSMTAYTNHTILAEALEKWPLEFLQEVVPHL
                     VPIIEELDRRVKAEYKDPAVQIIDESGRVHMAHMDIHYGYSVNGVAALHTEILKNSEL
                     KAFYDLYPEKFNNKTNGITFRRWLMHANPRLSHYLDEILGDGWHHEADELEKLLSYED
                     KAAVKEKLESIKAHNKRKLARHLKEHQGVEINSNSIFDIQIKRLHEYKRQQMNALYVI
                     HKYLDIKAGNIPARPITIFFGGKAAPAYTIAQDIIHLILCMSEVIANDPAVAPHLQVV
                     MVENYNVTAASFLIPACDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAE
                     LVGEENIYIFGEDSETVIDLYAKAAYKSSEFYAREAIKPLVDFIVSDAVLAAGNKERL
                     ERLYNELINKDWFMTLLDLEDYIKVKEQMLADYEDRDAWLDKVIVNISKAGFFSSDRT
                     IAQYNEDIWHLN"
     gene            complement(29546..30394)
                     /locus_tag="VVO18_000140"
     CDS             complement(29546..30394)
                     /locus_tag="VVO18_000140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methyltransferase domain-containing protein"
                     /protein_id="HEU5585366.1"
                     /translation="MNTNLKPKLQRFASATAFACPICQENLTLLETNFKCCNRHSFDL
                     AKFGYVNLAPQIKQSANYDKENFQNRQQILEAGFYQAILDAVSDLLASSKTTTTILDI
                     GCGEGFYSRKLQESHSEKTFYAFDISKDSVQIAAKSEPNWAVNWFVGDLARLPIKDAN
                     MDILLDIFSPANYGEFRRVLSKDGILIKVIPTENHLKEIRQRVQDQLTNKEYSNQDIK
                     EHFQEHFTILSSQSASLTKTITAEQLQALLSMTPLLFHVDQSKIDWSQLTEITIEAEI
                     LVGKAF"
     gene            30546..30824
                     /locus_tag="VVO18_000141"
     CDS             30546..30824
                     /locus_tag="VVO18_000141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003075836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585367.1"
                     /translation="MLKEVLTVAKVAKKSSLFLGGVAFGTLGLKILASKEAKKGYSKA
                     LAKAYKLKDELDASVSVVKQHGDDVLQDAKYLYEQEKKEEQLDSLIGE"
     gene            30826..32889
                     /locus_tag="VVO18_000142"
     CDS             30826..32889
                     /locus_tag="VVO18_000142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEU5585368.1"
                     /translation="MSFKVLHRGYQHIRLSSSFSLTLDIQDYLRSLARDEKGIESIQF
                     YMDQQHFTLRIKEGFSVLDNAEAFLKRIDKGKVSELMTLPIRREESAYSIVSGAAVKR
                     VLFRSFVPYPIRYIWTCYQALGYIREAYQTLARKELTMEVLDCSAILLSLFMNQSKTA
                     SNIMFMLDLGNHLDQWSLKKTATDLEQSLLAKESDVFLVQGDTVVSIKSSDVQIGDVL
                     ILSQGNEILFDGQVVSGLGMVNESSLTGESFPVEKREFDLVCANTVLETGELRIRVTD
                     NQMNSRILQLIELMKKSEENKKTKQRYFIKMADKVVKYNFLGAGLTYLLTGSFSKAIS
                     FLLVDFSCALKISTPVAYLTVIKEGLNREMVIKDGDVLEKYLEVDTFLFDKTGTITTS
                     YPIVEKVLPFGDYSEKDILRISACLEEHIYHPIANAIVKQAEIEGIEHEEMHGKLQYI
                     ASKGIKSHIDGQPVLIGNYVLMQDEQIHISSEQNALIEEYKSHYNLLFLAYQNELIGM
                     FCIHTPLRKEAKTALDKLKAQGKKLILATGDTLVRTEELVKDLPFDQVYTDLKPDGKF
                     ELVEKLQKAGHTILMVGDGLNDSAALTLSDIGVVMNESADISKQMSDILLLDNRLDFF
                     QELDSLSSSLQTLIKKNIQDTVVVNSSLIGFGLFNWLSPSNLSILHNLTTLRIVLRSL
                     SIKNR"
     gene            complement(32967..34223)
                     /locus_tag="VVO18_000143"
     CDS             complement(32967..34223)
                     /locus_tag="VVO18_000143"
                     /EC_number="6.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine--tRNA ligase"
                     /protein_id="HEU5585369.1"
                     /translation="MHIFDELKDRGLIFQTTDEEALRKALEEGQVSYYTGYDPTADSL
                     HLGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFKDAERSLQTKDTVDGWVKSIQ
                     GQLSRFLDFENGENKAVMVNNYDWFGSISFIDFLRDIGKYFTVNYMMSKESVKKRIET
                     GISYTEFAYQIMQGYDFFVLNQDHNVTLQIGGSDQWGNMTAGTELLRRKADKTGHVIT
                     VPLITDATGKKFGKSEGNAVWLNPEKTSPYEMYQFWMNVMDADAVRFLKIFTFLSLDE
                     IEDIRKQFEAAPHERLAQKVLAREVVTLVHGEEAYKEALNITEQLFAGNIKNLSVKEL
                     KQGLRGVPNYQVQADENNNIVELLVSSGIVNSKRQAREDVQNGAIYVNGDRIQELDYV
                     LSDADKLENELTVIRRGKKKYFVLTY"
     gene            34365..36830
                     /locus_tag="VVO18_000144"
     CDS             34365..36830
                     /locus_tag="VVO18_000144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEU5585370.1"
                     /translation="MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKS
                     AIFPAILLSIKALFNLLFVLGFLGGMLGVGIALGYGVALFDKVRVPQTEELVNQVKDI
                     SSISEITYSDGTVIASIESDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAV
                     IRATLGKFVGLGSSSGGSTLTQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEI
                     LTTYLNVAPFGRNNKGQNIAGARQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPY
                     ENTGELKSDEDLEIGLRRAKAVLYSMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGI
                     SRDYLYFTTLAEAQERMYDYLAQRDNVSAKELKNEVTQKFYRDLAAKEIENGGYKITT
                     TIDQKIHSAMQSAVADYGYLLDDGTGRVEVGNVLMDNQTGAILGFVGGRNYQENQNNH
                     AFDTKRSPASTTKPLLAYGIAIDQGLMGSETILSNYPTNFANGNPIMYANSKGTGMMT
                     LGEALNYSWNIPAYWTYRMLREKGVDVKGYMEKMGYEIPEYGIESLPMGGGIEVTVAQ
                     HTNGYQTLANNGVYHQKHVISKIEAADGRVVYEYQDKPVQVYSKATATIMQGLLREVL
                     SSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDENMWLMLSTPRLTLGGWIGHDDNH
                     SLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALDPSVVKSEVLKSTGQKPGKVS
                     VEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQNAWSSIVGSLPTPSSSSS
                     SSSSSSDSSNSSTTRPSSSRARR"
     gene            36895..37806
                     /locus_tag="VVO18_000145"
     CDS             36895..37806
                     /locus_tag="VVO18_000145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEU5585371.1"
                     /translation="MNQYQKKIVNGKIYSLLSGLIWGICGILGEYFFTHYQVSSGWIT
                     SMRLTLAGSLVLIWSAIQLKSQVLDIWRDKKNYLPFLAYAILGIFSVQYFFYLCVEYS
                     NATTATILQFISPVFILFYNRLVYQKRASKSAVFYVLVAMLGVCLMATKGDLSQLSMT
                     PLALITGLLSAMGVMFNVILPQPFAKRYGFVPTVGWGMILAGLFSNVLSPVYQLSFTL
                     DIWSILICLIIAFFGTAFAFFISMKAVSLVSPLVVAVISASEPLSSALLSVLFLGLVV
                     DWSLLLAIALIILPMIFLSIEEAKESR"
     gene            38036..38734
                     /gene="dapD"
                     /locus_tag="VVO18_000146"
     CDS             38036..38734
                     /gene="dapD"
                     /locus_tag="VVO18_000146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466315.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate
                     N-acetyltransferase"
                     /protein_id="HEU5585372.1"
                     /translation="MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLG
                     NVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVKI
                     GDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPVSAE
                     PVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQ
                     TQQKTALEDALRTL"
     gene            38802..39932
                     /locus_tag="VVO18_000147"
     CDS             38802..39932
                     /locus_tag="VVO18_000147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetyldiaminopimelate deacetylase"
                     /protein_id="HEU5585373.1"
                     /translation="MLDLIQTRRDLHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQI
                     RTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLPFASQHQGRMHACGHDFHMTI
                     ALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEAGAFGDWLPDQFYGLHVRPDLK
                     VGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVAASYFVTQVQSVVSRNVN
                     PIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGIAAAFD
                     MEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDG
                     VMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE"
     gene            39944..40483
                     /locus_tag="VVO18_000148"
     CDS             39944..40483
                     /locus_tag="VVO18_000148"
                     /EC_number="6.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="HEU5585374.1"
                     /translation="MKSELRKQVLHEMKALSQEQKQAIDQALTERILQHPFYQEAKVI
                     ATYLSFSHEFQTRELIEQALKDGKKVLIPKTYPKGRMDFVVYDPQQLVKTAFALLEPQ
                     GDLEVVDVSQIDLIHVPGLAFTTDGYRIGYGGGYYDRYLEHFSGHTLSTVHPCQIQDF
                     IPENHDIPVQEVLIDEGNL"
     gene            40467..41144
                     /locus_tag="VVO18_000149"
     CDS             40467..41144
                     /locus_tag="VVO18_000149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="HEU5585375.1"
                     /translation="MKEIFDRRYPVTSFFLLVTALVFLLMLVTAGGNFDRADTLFRFG
                     AMYGPAIRLFPEQVWRLLSAIFVHIGWEHFIVNMLSLYYLGRQVEEIFGSKQFFFLYL
                     LSGMMGNLFVFVFSPKSLAAGASTSLYGLFAAIIVLRYATRNPYIQQLGQSYLTLFVV
                     NIIGSVLIPGISLAGHIGGAVGGAFLAVIFPVRGEKRMYNTSQRLGAVVLFVGLAILL
                     FYKGMGM"
     gene            complement(41216..42115)
                     /gene="galU"
                     /locus_tag="VVO18_000150"
     CDS             complement(41216..42115)
                     /gene="galU"
                     /locus_tag="VVO18_000150"
                     /EC_number="2.7.7.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="HEU5585376.1"
                     /translation="MTSKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVE
                     EALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLKEKGKTDLLKLVDKTTDMRLHFI
                     RQTHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDEKAVPLTKQLMDDYERTHAST
                     IAVMPVPHDEVSAYGVIAPQGEGKDGLYSVETFVEKPAPEDAPSDLAIIGRYLLTPEI
                     FQILENQAPGAGNEIQLTDAIDTLNKTQRVFAREFNGARYDVGDKFGFMKTSIDYALK
                     HPQVKDDLKNYLIQLGKELTEKE"
     gene            complement(42137..43153)
                     /locus_tag="VVO18_000151"
     CDS             complement(42137..43153)
                     /locus_tag="VVO18_000151"
                     /EC_number="1.1.1.94"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="HEU5585377.1"
                     /translation="MEKQTVAVLGPGSWGTALSQVLNDNGHEVRIWGNLPEQINEINT
                     HHTNKHYFKDVVLDENIIAYTDLAETLKDVDAILFVVPTKVTRLVAQQVAQTLDHKVI
                     IMHASKGLEPDSHKRLSTILEEEIPEHLRSDIVVVSGPSHAEETIVRDLTLITAASKD
                     LQTAQYVQKLFSNHYFRLYTNTDVIGVETAGALKNIIAVGAGALHGLGFGDNAKAAII
                     ARGLAEITRLGVALGASPLTYSGLSGVGDLIVTGTSIHSRNWRAGDALGRGESLADIE
                     ANMGMVIEGISTTRAAYELAQELGVYMPITQAIYQVIYHGTNIKDAIYDIMNNEFKAE
                     NEWS"
     gene            43365..43745
                     /locus_tag="VVO18_000152"
     CDS             43365..43745
                     /locus_tag="VVO18_000152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5585378.1"
                     /translation="MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRP
                     TLTKLKYIAERLGVEDYKLMPSYIELDKEYLELKYFLMRTPTYEDETIAQKKESVLIR
                     FLKSIMIGYLRKKDLSSQIIHIWH"
     gene            complement(43919..44344)
                     /locus_tag="VVO18_000153"
     CDS             complement(43919..44344)
                     /locus_tag="VVO18_000153"
                     /inference="COORDINATES: protein motif:HMM:NF025080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5585379.1"
                     /translation="MTNLSSVDSEELFQFYRERGNAENFIKERKAGFFGDKTDSSTMI
                     KNEVRMMMGCLAYNLYLFLKQLAGDEVKALTIKRFRRLFLHIAGKYVSTARRHILKFS
                     SLYAYSKQFQALFDTICQINLILPVPYRARGQGKTCLTE"
     gene            complement(44412..45062)
                     /gene="phoU"
                     /locus_tag="VVO18_000154"
     CDS             complement(44412..45062)
                     /gene="phoU"
                     /locus_tag="VVO18_000154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245788.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEU5585380.1"
                     /translation="MRNQFDLELHELEQSFLGLGQLVLETASKALLALASKDKEMAEL
                     IINKDHAINQGQSAIELTCARLLALQQPQVSDLRFVISIMSSCSDLERMGDHMAGIAK
                     AVLQLKENQLAPDEEQLHQMGKLSLSMLADLLVAFPLHQASKAISIAQKDEQIDQYYY
                     ALSKEIIGLMKDQETSIPNGTQYLYIIGHLERFADYIANICERLVYLETGELVDLN"
     gene            complement(45077..45829)
                     /gene="pstB"
                     /locus_tag="VVO18_000155"
     CDS             complement(45077..45829)
                     /gene="pstB"
                     /locus_tag="VVO18_000155"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU5585381.1"
                     /translation="MGTFSVRHLDLFYGDFQALKNISIQLPERQITALIGPSGCGKST
                     FLKTLNRMNDLVPSCHIEGQVLLDEQDIYSSKFNLNQLRKRVGMVFQQPNPFAMSIYD
                     NVAYGPRTHGIRDKKQLDALVEKSLKGAAIWEEVKDDLKKSAMSLSGGQQQRLCIARA
                     LAVEPDVLLMDEPTSALDPISTLKIEDLIQQLKKDYTIIIVTHNMQQASRISDKTAFF
                     LTGEICEFGDTVDVFTNPKDQRTEDYISGRFG"
     gene            complement(45831..46646)
                     /gene="pstA"
                     /locus_tag="VVO18_000156"
     CDS             complement(45831..46646)
                     /gene="pstA"
                     /locus_tag="VVO18_000156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015057412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEU5585382.1"
                     /translation="MSKYLLKLLVYCFSALTFGSLFLIIGFILIKGLPHLSLSLFSWT
                     YTSENISLMPAIISTVILVFGALLLALPIGIFAGFYLVEYTKKDSLCVKIMRLASDTL
                     SGIPSIVFGLFGMLFFVVFLGFQYSLLSGILTSVIMVLPVIIRSTEEALLSVSDSMRQ
                     ASYGLGAGKLRTVFRIVLPVAMPGILAGVILAIGRIVGETAALMYTLGTSTNTPSSLM
                     SSGRSLALHMYMLSSEGLHVNEAYATGVILIITVLMINTLSSLLSRKLVKGAS"
     gene            complement(46639..47502)
                     /gene="pstC"
                     /locus_tag="VVO18_000157"
     CDS             complement(46639..47502)
                     /gene="pstC"
                     /locus_tag="VVO18_000157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEU5585383.1"
                     /translation="MIKQAFKEAVFRAIFFMSATVAVVAILLICFFIFSNGLPFMANY
                     GFARFLLGSDWSPTNIPASYGILPMIVGSLLITLGAIVIGVPTGILTSVFMVYYCPKP
                     VYGFLKSAINLMAAIPSIVYGFFGLQLLVPWIRTFLGNGMSVLTASLLLGIMILPTII
                     SLSESAIRTVPKTYYSGSLALGASHERSIFSVILPAARSGILSAVILGIGRAVGETMA
                     VILVAGNQPIIPSGLFSGTRTLTTNIVLEMAYASGQHREALIATSAVLFFLILLINAY
                     FAYLKGKSSYE"
     gene            complement(47620..48495)
                     /locus_tag="VVO18_000158"
     CDS             complement(47620..48495)
                     /locus_tag="VVO18_000158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate-binding protein"
                     /protein_id="HEU5585384.1"
                     /translation="MKFKKMLTLAAIGLSGFGLVACGNQSAASKQSASGTIEVISREN
                     GSGTRGAFTEITGILKKDGDKKIDNTAKTAVIQNSTEGVLSAVQGNANAIGYISLGSL
                     TKSVKALEIDGVKASRDTVLDGEYPLQRPFNIVWSSNLSKLGQDFISFIHSKQGQQVV
                     TDNKFIEAKTETTEYTSQHLSGKLSVVGSTSVSSLMEKLAEAYKKENPEVTIDITSNG
                     SSAGITAVKEKTADIGMVSRELTPEEGKSLTHDAIALDGIAVVVNNDNKASQVSMAEL
                     ADVFSGKLTTWDKIK"
     gene            complement(48662..49993)
                     /locus_tag="VVO18_000159"
     CDS             complement(48662..49993)
                     /locus_tag="VVO18_000159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component sensor histidine kinase"
                     /protein_id="HEU5585385.1"
                     /translation="MKRYLQFWLVNLSVSLILIAGMALTWISKGIGLFLLALSLGLGG
                     YWLFCLWKWEVAFETLHQPLLTSSEYFLEKGQEDLKSLAQYVSGLKTKVSQQDQQYKD
                     LAETMEVLLSHLTMGTFLVSAQGQMLLSSRSLPHYFPDVDGDISSLDDLKRMDIRNLV
                     HQAFDQKTRLKQEVSGFHEGDLILEVTAVPVFSPTQSVEAVLVLLYDLTTIRTYEKLN
                     LAFVSNASHELRTPVTSIKGFAETIKGMSAEEEALKDDFLDIIYKESLRLEHIVEHLL
                     TLSKAQQMPIQWTTLSLAEFVQDLTQSLQPQLKKKDLQLKVQVPDDVTLVSDSQLLSQ
                     ILLNLLSNAIRYTEQGGKIEVKTQKVNEGIKISVSDTGIGISQLEQDRIFERFYRVNK
                     GRSRQTGGTGLGLAIVKELSQLLGGQVTVTSQLGRGSCFTIFLPNQSFAQD"
     gene            complement(49994..50701)
                     /locus_tag="VVO18_000160"
     CDS             complement(49994..50701)
                     /locus_tag="VVO18_000160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585386.1"
                     /translation="MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAET
                     EPFDFILLDIMLPQLDGMEVCKRLRAKGVKTPIMMVSAKSDEFDKVLALELGADDYLT
                     KPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
                     LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKA
                     PQFIRTIRGYGYKFKEL"
     gene            complement(50785..51270)
                     /locus_tag="VVO18_000161"
     CDS             complement(50785..51270)
                     /locus_tag="VVO18_000161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855144.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupin domain-containing protein"
                     /protein_id="HEU5585387.1"
                     /translation="MAPTDKEDLIRTLELAPHIEGGYFRQTKKASDTINLAGKGRALY
                     TSIYFLLEETNPSHFHRLTADEIWYFHAGSPLTVHMITADGHYEAVTLGLDISKGQQL
                     HYCVPKGTIWGSTVDKDDALVSCLVAPGFEFEDFELFERVDLLATYPEHKEMIERLTR
                     Y"
     gene            51256..51813
                     /locus_tag="VVO18_000162"
                     /pseudo
     CDS             51256..51813
                     /locus_tag="VVO18_000162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(52128..53819)
                     /locus_tag="VVO18_000163"
     CDS             complement(52128..53819)
                     /locus_tag="VVO18_000163"
                     /EC_number="6.1.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine--tRNA ligase"
                     /protein_id="HEU5585388.1"
                     /translation="MNTKELIASELASIIDSLDQEAILKLLETPKNSEMGDIAFPAFS
                     LAKVERKAPQMIAAELAEKMNSQAFEKVVATGPYVNFFLDKSAISAQVLQAVTTEKEH
                     YADQNIGKQENVVIDMSSPNIAKPFSIGHLRSTVIGDSLSHIFQKIGYQTVKVNHLGD
                     WGKQFGMLIVAYKKWGDEEAVKAHPIDELLKLYVRINAEAENDPSLDEEAREWFRKLE
                     NGDEEALALWQWFRDESLVEFNRLYNELKVEFDSYNGEAFYNDKMDAVVDILSEKGLL
                     LESEGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKNEYQFAKSIYVVGQE
                     QSAHFKQLKAVLQEMGYDWSDDITHVPFGLVTKEGKKLSTRKGNVILLEPTVAEAVSR
                     AKVQIEAKNPELENKDQVAHAVGIGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYV
                     QYAYARIQSILRKADFKPETAGNYSLNDTESWEIIKLIQDFPRIINRAADNFEPSIIA
                     KFAISLAQSFNKYYAHTRILDESPERDSRLALSYATAVVLKEALRLLGVEAPEKM"
     gene            53955..54401
                     /gene="argR"
                     /locus_tag="VVO18_000164"
     CDS             53955..54401
                     /gene="argR"
                     /locus_tag="VVO18_000164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227366.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU5585389.1"
                     /translation="MRKRDRHQLIKKMITEEKLSTQKEIQDRLEAHNVCVTQTTLSRD
                     LREIGLTKVKKNDMVYYVLVNETEKIDLVEFLSHHLEGVARAEFTLVLHTKLGEASVL
                     ANIVDVNKDKWILGTVAGANTLLVICRDQHVAKLMEDRLLDLMKDK"
     gene            54452..56986
                     /gene="mutS"
                     /locus_tag="VVO18_000165"
     CDS             54452..56986
                     /gene="mutS"
                     /locus_tag="VVO18_000165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair protein MutS"
                     /protein_id="HEU5585390.1"
                     /translation="MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAA
                     QILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVV
                     KREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
                     VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQT
                     ASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLF
                     WLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFFERSDLTDSLKGVYD
                     IERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPTLAYLIAQLDAIPELES
                     LISAAIAPEAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTL
                     KIDYNKKDGYYFHVTNSQLGNVPAHFFRKATLKNSERFGTEELARIEGDMLEAREKSA
                     NLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFGDDSQID
                     IRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQL
                     GSYVPAESAHLPIFDAIFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDE
                     LGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHELTSLESSLQHLVNVHVATLEQ
                     DGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQT
                     SAVTEHISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL"
     gene            57133..58827
                     /gene="patA"
                     /locus_tag="VVO18_000166"
     CDS             57133..58827
                     /gene="patA"
                     /locus_tag="VVO18_000166"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatA"
                     /protein_id="HEU5585391.1"
                     /translation="MLIQKIKTYKWQALASLLMTGLMVASSLLQPRYLQEVLGALLTG
                     KYEAIYSIGAWLIGVAVVGLVAGGLNVVLAAYIAQGVSSDLREDAFRKIQTFSYADIE
                     QFNAGNLVVRMTNDINQIQNVVMMTFQILFRLPLLFIGSFILAVQTLPSLWWVIVLMV
                     VLIFGLTAVMMGIMGPRFAKFQTLLERINAIAKENLRGVRVVKSFVQEKEQFAKFTEV
                     SDELLGQNLYIGYAFSVVEPFMMLVGYGAVFLSIWLVAGMVQSDPSVVGSIASFVNYL
                     SQIIFTIVMVGFLGNSVSRAMISMRRIREILDAEPAMTFKDIPDEELVGSLSFENVTF
                     TYPMDKEPMLKVVSFTIEPGQMVGVVGATGAGKSTLAQLIPRLFDPQDGAIKIGGKDI
                     REVSEGTLRKTVSIVLQRAILFSGTIADNLRQGKGNATLFEMERAANIAQASEFIHRM
                     EKTFESPVEERGTNFSGGQKQRMSIARGIVSNPRILIFDDSTSALDAKSERLVQEALN
                     KDLKGTTTIIIAQKISSVVHADKILVLNQGRLIGQGTHADLVANNAVYREIYETQK"
     gene            complement(59158..59427)
                     /locus_tag="VVO18_000167"
                     /pseudo
     CDS             complement(59158..59427)
                     /locus_tag="VVO18_000167"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019770457.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            59619..61385
                     /gene="patB"
                     /locus_tag="VVO18_000168"
     CDS             59619..61385
                     /gene="patB"
                     /locus_tag="VVO18_000168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000859866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux ABC transporter subunit PatB"
                     /protein_id="HEU5585392.1"
                     /translation="MKTVQFFWHYFKVYKFSFVVVILMIVLATFAQALFPVFSGQAVT
                     QLANLVQAYQNGNPELVWQSLSGIMVNLGLLVLVLFISSVIYMCLMTRVIAESTNEMR
                     KGLFGKLAQLTVSFFDRRQDGDILSHFTSDLDNILQAFNESLIQVMSNIVLYIGLILV
                     MFSRNVTLALITIASTPLAFLMLIFIVKMARKYTNLQQKEVGKLNAYMDESISGQKAV
                     IVQGIQEDMMAGFLEQNERVRKATFKGRMFSGILFPVMNGMSLINTAIVIFAGSAVLL
                     NDKSIETSTALGLIVMFAQFSQQYYQPIIQVAASWGSLQLAFTGAERIQEMFDAEEEI
                     RPEKAPTFTKLQESVEISHIDFSYLPDKPILKDISISAPKGQMTAVVGPTGSGKTTIM
                     NLINRFYDVDAGGIYFDGKDIRGYDLDSLRSKVGIVLQDSVLFSGTIRDNIRFGVPDA
                     SQEMVEVAAKATHIHDYIESLPDKYDTLIDDDQSIFSTGQKQLISIARTLMTDPEVLI
                     LDEATSNVDTVTESKIQHAMEVVVAGRTSFVIAHRLKTILNADQIIVLKDGEVIERGN
                     HHELLKLGGFYSELYHNQFVFE"
     gene            61524..62213
                     /locus_tag="VVO18_000169"
     CDS             61524..62213
                     /locus_tag="VVO18_000169"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEU5585393.1"
                     /translation="MARTVVGVTANLCPVDAEGKIIHSSVSCRFAEIIRQVGGLPLVI
                     PVGDESVVRDYVEMIDKLILTGGQNVHPQFYGEKKTVESDDYNLVRDEFELALLKEAL
                     RQNKPIMAICRGVQLVNVAFGGTLNQEIEGHWQGLPFGTSHSIETVEGSVVAKLFGKE
                     SQVNSVHRQSIKDLAPNFRVTAIDSRDQTIEAIESIDEHRIIGLQWHPEFLVNEEDGN
                     LELFEYLLNEL"
     gene            62217..62396
                     /locus_tag="VVO18_000170"
     CDS             62217..62396
                     /locus_tag="VVO18_000170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866816.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585394.1"
                     /translation="MEYLVVLSFIFSKFLECGILRKRLNSDKNWRNSTKKLEKNEGKR
                     YDRKEEILEEEHVTY"
     gene            62383..63732
                     /locus_tag="VVO18_000171"
     CDS             62383..63732
                     /locus_tag="VVO18_000171"
                     /EC_number="5.3.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="HEU5585395.1"
                     /translation="MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSD
                     FLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFAN
                     LQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFK
                     ELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWETFVVPDDIGGRFSVLTAVGLL
                     PIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEP
                     SLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDK
                     PRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAF
                     TLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL"
     gene            63856..65316
                     /locus_tag="VVO18_000172"
     CDS             63856..65316
                     /locus_tag="VVO18_000172"
                     /EC_number="6.1.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate--tRNA ligase"
                     /protein_id="HEU5585396.1"
                     /translation="MSKDIRVRYAPSPTGLLHIGNARTALFNYLYARHHGGTFLIRIE
                     DTDRKRHVEDGERSQLENLRWLGMDWDESPESHENYRQSERLDLYQKYIDQLLAEGKA
                     YKSYVTEEELAAERERQEVAGETPRYINEYLGMSEEEKAAYIAEREAAGIIPTVRLAV
                     NESGIYKWHDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVIDDHDMQISHVIRGD
                     DHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYL
                     PEAVFNFIALLGWNPGGEDEIFSREELIKLFDENRLSKSPAAFDQKKLDWMSNDYIKN
                     ADLETIFEMAKPFLEEAGRLTDKAEKLVELYKPQMKSVDEIIPLTDLFFSDFPELTEA
                     EREVMTGETVPTVLEAFKAKLEAMTDDKFVTENIFPQIKAVQKETGIKGKNLFMPIRI
                     AVSGEMHGPELPDTIFLLGREKSIQHIENMLKEISK"
     gene            65330..65764
                     /locus_tag="VVO18_000173"
     CDS             65330..65764
                     /locus_tag="VVO18_000173"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEU5585397.1"
                     /translation="MDIWEKMYEEAQKLYNPHEVSDFVYANHVVAAVEAEDGQIFTGF
                     CMEGTCGVFHLCAERAALFNMYQFSGQTKVKKVLAFRDKPPYGGSSAMPCGACREFLL
                     ELNAENKDAEFMMDYNIRKTVKVAELIPYWWGEERASKFNER"
BASE COUNT        19335 a        12238 c        14338 g        19918 t
ORIGIN      
        1 gagaaatgtt tgattataga gcactagtta ttttgatgac tttgatggat cattgtgagc
       61 tatcattata tgaattatct gttaaggtga gcttacctat aaaggaagtc aaagaaggaa
      121 tagattattt agtgccttat ctagctaata aagggatagt gctggataaa aaacaaggtc
      181 gctatagttt atcaaatcgt acgaagcagt ctttgacaga tattattaag tcggatgaat
      241 tggttttacc aaagtcgact cgcttagctt taatctatct ttacactttt tgccgattag
      301 attttatatc gaataatcat taccaagact ttttgaaagt aagtaagaat acaaccttat
      361 ctgatattca atcattaaga aagattatgt tagataatga tttggagcta gggtacagta
      421 gagcaaaagg ttatacttta cacggttcag agtggaataa gcaccgttta gcttttcaaa
      481 tggttagtga gttgctggaa tcctccatag ggatttgggg tttggattat gttttatcca
      541 gttggggata ttcattaact tatgatttga ttgatcaggt agttaaagat tattatgaga
      601 agctacagct agtacctatt gttaatcaat taaaagttta ccttttcggt ttagtattca
      661 ttctgtgtag gtatcaaagg gatgttgaaa gagtatgtct ttcagagaca ttagtatctc
      721 ctgttattca agatataacg actattttat tggatacagt ggttgatttg ggaattatag
      781 atacggtgtt ttctgaggat gattatcgct atatcacagt tttattatca agttgctttg
      841 aaggtgaagt agatgttgct ccggtttact ttaatcaatt aacagaggct attataagta
      901 gaatggaaga tatttctttg ttacatttta aacaaaggga aggattgaga gaaaatcttc
      961 gtcgccacct tataccggct tactatagat taaagttcgg cctacctagt tcaaatgaat
     1021 atgtattgca tgttaaagaa cattatcctg atttatttga attagtcaaa gattctttga
     1081 tgcccttgat ggacgctatt gacaatccca tacctgatag tgaaacagca tattttgtta
     1141 tccatttcgg aggttattta aagaaagcag atactttgcc tcaaaaatgg tataaagcag
     1201 caatcatttg tcctaatggt gttagttctt cattgatgtt aaaagagaat ctattagcat
     1261 tatttcctca aattgagttt ataggaacct caaagattga tgatttacag gtgaaagcta
     1321 gtagtgacta tgatatggtt ttttctacca taaaggtgga gacagaaaag ccaaattatc
     1381 tagtttcggt tatgatgact gaagagcaag caatacaact agtagaacta gtgttaaaag
     1441 attttccgaa tttagagtat ggagattttg agattgaaca aatcctgaat attgtcaaaa
     1501 gatatggaat tattacacaa gaattggaat taagattggc gttaaagaat tatctttatc
     1561 aaaaaaatga tagaaaggaa attgtaccag tgctagaaca acttattacc aaagaaacct
     1621 atcaggttag ttcgcaaaaa ttaggatgga aggaggcgat tcgtttagca gctaaaccgc
     1681 ttttggatca agataagata acggagaact accctgaggc aatgattcaa aaagtagaag
     1741 agtttggacc ttttattaat ttagggaagg gagtagcaat tcctcacgct cggccagatg
     1801 aaggtgtgaa tgaaatagga atgtcaatgt tagttttgga agaaccgatt tatttattgg
     1861 ataatccaga acaagaggta agattgttga tttgtattgc agccattgat aatgagagtc
     1921 atttaaaggc tttgtcacat ttaacaacaa ttttaagaga taaaaatcat gttcaaactt
     1981 taatttcatc aaaaaactat gatgacatta aaatgataat taaacaggag gattagataa
     2041 tgttaaaaat tggtacagct tgtggttcag gattaggttc aagttttatg gtacagatga
     2101 atattgaatc tgtattgagt gatttgaatg tttcggatgt agaagttgaa cattatgatt
     2161 taggtggagc agatccaaat gcagctgata tttggattgt tggtcgtgat ctagctgatt
     2221 cagctagtca tcttggagat gttcgtatct taaatagtat tattgatatg gatgaactac
     2281 gagaattaat tactaaactt tgtgaagaaa aaggacttat ataggaggct agcgttatga
     2341 tgaagttcat attggatatt gttagtacac cagctatttt agtagcttta attgcaattt
     2401 taggattagt tcttcagaag aagaaattac ctgatattat taaaggtgga attaagacct
     2461 ttgttggttt cttagttgta tctggtggtg caggaattgt acaaaattct ttaaatccat
     2521 ttggtaccat gtttgagcat gcttttcatt tatctggcgt tgtgccgaat aatgaagcaa
     2581 ttgtagctgt agctttaaca acatatggct cagctactgc actgattatg tttgcaggca
     2641 tggtgttcaa tatcttaatc gctcgtttta ctcgatttaa atatatcttt ttaacagggc
     2701 accacactct atatatggca tgtatgattg cggtcatttt atcagttgct ggctttacta
     2761 gcttgcctct catcttacta ggaggattag cactcggtat tattatgagt atttccccag
     2821 catttgtgca aaaatatatg gttcaattaa ctggaaatga caaggtggct ttaggtcatt
     2881 tcagttcttt gggatattgg ttgagtggtt ttactggtag ccttatcggt gacaaatcaa
     2941 aatcaacaga ggacattaaa tttccaaaga gtttagcttt tttacgtgat agtactgtta
     3001 gtatcacttt atctatggca gttatttaca ttattgtagc tatctttgca gggtcagaat
     3061 atatagaaaa agaaatcagt agtggtacaa gtggtctagt ttatgcttta caattagcag
     3121 gtcaatttgc agcaggggta tttgttattt tagcaggtgt tcgccttatt ttgggtgaaa
     3181 ttgttccagc ctttaaaggt atttcagagc gtcttgtacc taattcaaaa cctgctttgg
     3241 attgtccgat tgtttatact tatgcaccca atgcagttct aattggattt atctctagtt
     3301 ttattggtgg tttagtaagt atggcaatta tgattgcttc aggaacggtt gttatcttac
     3361 caggtgttgt gcctcatttc ttctgtggag cgactgcagg tgtcattggg aatgcatctg
     3421 gtggtgttcg tggagccact attggagcat ttttacaagg tattttaatc agttttcttc
     3481 cagtcttttt aatgccagtt ttgggaggac ttggtttcca aggatcaact ttctcagatg
     3541 cagattttgg tctatcagga attattttag gaatgttaaa tcaatttggc tcacaagcag
     3601 gcattgtgat tggtcttgtt cttattctag cagttatgtt tggagtatcc tttattaaaa
     3661 agccatctgc aaaggaggaa taagggatga ttttaagtaa aaatagagaa gatgagttaa
     3721 gaaaatttgc gactaacatc cgattaaata ctcttagaac attgaatcat cttggattcg
     3781 gacattacgg aggaagtctg tctatcgtag aagttttagc ggtgctttat ggtgaaataa
     3841 tgccaatgac tccagaaata tttgcagcac gagatagaga ttatttcata ttatcaaaag
     3901 gtcatggagg accagctcta tacagtacac tctatttgaa tggtttcttt gacaaagaat
     3961 tcttatattc tttaaataca aatggaacca aattaccgtc tcatcctgat agaaatctaa
     4021 cgccaggcat agatatgaca acgggctctt taggacaagg aattagtgtt gcaactggac
     4081 ttgcatatgg tcagagaata agaaagagtc ccttttatac ttatgctatt gttggagatg
     4141 gtgagttaaa tgaaggacaa tgttgggagg ctatacagtt tgcttctcat caacagttat
     4201 ccaacttaat tgtatttgtt gatgataaca aaaaacaatt agatggtttt acaaaggata
     4261 tttgtaatcc aggtgatttc gtagaaaaat tttcagcatt tggatttgaa tccattaggg
     4321 tcaagggttc agatattaga gaaatttatg aagggattgt ccaattaaaa cagtcaaata
     4381 attcatcacc taagtgcatt gtattagata ctattaaagg tcaaggggtt caagagctgg
     4441 aagaaatgaa atccaatcat catcttcgcc ctactgtaga ggagaaacaa atgttaactt
     4501 cagttgtaga aagattaagt caggaattgg aggaaacaga atgatgagaa gtacgaaaga
     4561 attacggcat gtatatagag acttcctttt agaggctaat caaagttctt ctgatatagt
     4621 agtcttagaa gccgatttgt caagttcgat ggctactcat aatcttgaaa aggactttgg
     4681 agaccgttat gtgaatgttg ggattatgga agcagaaatg gtcggccttg cagcaggctt
     4741 gtctattcag gggtttagac cttatcttca tacatttggt cctttttctt cacgaagggt
     4801 atttgatcaa ttatttattt ctcttggata cgcacaattg gatgccactg tgattggatc
     4861 agatgcagga gtaactgcag aaatgaatgg tgggacacat atgccatttg aagaaattgg
     4921 attgttacgt ttaattccta aatcgatcat ttttgaagca actgatgata tccaatttcg
     4981 tgaaatattg aaccagacat tagacttaaa aggactaaaa tatattcgaa caattagaaa
     5041 agctccagtt cctgtgtatc aaggtggaga agatttttct aaaggctaca ttgagttaag
     5101 acatggtgaa gatcttgtaa tcgttgcttc tggtataatg gttgctccaa gtattcgagt
     5161 tgcagatgaa ctgtctaaat taggttattc agtaggtgtg atagatttat ttagaatcaa
     5221 accgatacca gaacagataa aaacaatgtt aagtggaaaa actatattta ctgtagaaaa
     5281 ccacaatcag ataggtggaa ttggcagttc tttatgtgaa ttattctctg atgatggaat
     5341 aacaaaaatt catcggatgg gtgttcaaga aagatttggt caagtaggga aaatggatta
     5401 tcttcttaat gagtatggtt tgagtgaatc gaatataaaa gagaaggttc tagaaattta
     5461 taatgcaaga tagatgttaa atacacttat ctgaaagaat ttctgtaaaa attacattac
     5521 gttatttaaa aaaagcggat taaaaagcat attctggtca tcagaaagtg cactaatccg
     5581 ctttgttgtt tttaatttta aatatttcac atgcgtatag aattttctga aaattcaaga
     5641 attttattct gttcattgcc tttaaattgt gctataatag taaaaactga aatgggaggg
     5701 ataagatgac tgaattagat aaacgtcacc gcagtagcat ttatgacagc atggttaaat
     5761 cacctaaccg tgctatgctt cgtgcgactg gtatgacaga taaggacttt gaaacatcga
     5821 ttgtaggagt gatttcgact tgggcggaaa atacaccatg taacattcac ttgcatgatt
     5881 tcgggaaact ggctaaagaa ggtgtcaaat ctgcaggcgc ttggcctgta cagtttggaa
     5941 ccattaccgt agcagacggg atcgctatgg gaacgcctgg tatgcgtttc tctctaacat
     6001 ctcgtgacat catcgcggac tccatcgagg cggctatgag tggtcacaac gtcgatgcct
     6061 tcgtcgctat cggtggctgt gacaagaaca tgcctggatc tatgattgct attgctaata
     6121 tggatatccc agctattttc gcctatggtg gaactattgc accgggaaat cttgatggta
     6181 aagatatcga cttggtttct gtctttgaag gtatcggaaa atggaaccac ggtgacatga
     6241 cagctgagga cgtgaaacgt cttgaatgta atgcctgccc tggccctggt ggttgtggtg
     6301 gtatgtatac tgctaatacc atggcaactg ctatcgaagt tctagggatg agtttgccag
     6361 ggtcatcctc tcacccagct gaatcagctg ataagaaaga agatatcgaa gcagcaggac
     6421 gtgctgttgt taagatgttg gaacttggtc tcaaaccatc agatatcttg actcgtgaag
     6481 cctttgaaga tgctattact gtaacgatgg ctctcggtgg ttctacaaac gccactcttc
     6541 acttgctcgc cattgcccat gccgcaaatg ttgacttgtc acttgaggac ttcaatacga
     6601 ttcaagaacg tgtgcctcac ttggccgact tgaaaccatc tggtcagtat gtcttccaag
     6661 acctctacga agtcggtggt gtccctgcgg ttatgaagta cttgttggca aatggtttcc
     6721 ttcacggaga tcgcatcaca tgtactggta agactgtagc tgaaaacttg gctgactttg
     6781 cagacttgac tccaggccaa aaagttatca tgccacttga aaatccaaaa cgtgcggatg
     6841 gtccgcttat catcttgaac gggaaccttg ctcctgacgg tgcagttgcc aaggtatcag
     6901 gtgttaaagt gcgtcgtcac gttgggccag ctaaggtctt tgactcagaa gaagatgcga
     6961 ttcaggccgt tctgacagat gaaatcgttg atggcgatgt agtcgttgtt cgttttgttg
     7021 gacctaaagg tggtcctggt atgcctgaga tgctgtcact ttcttcaatg attgttggta
     7081 aaggtcaggg agataaggtg gccctcttga cggacggacg tttctctggt ggtacttatg
     7141 gtctggttgt tggacatatc gctcctgaag ctcaggatgg tggaccaatt gcctatctcc
     7201 gtaccggcga tatcgttacg gttgaccaag ataccaaaga aatttccatg gccgtatccg
     7261 aagaagaact tgaaaaacgc aaggcagaaa caaccttgcc accactttac agccgtggtg
     7321 tcctcggtaa atatgcccac atcgtatcat ctgcttcacg cggagccgtg acagacttct
     7381 ggaatatgga caagtcaggt aaaaaataaa ctcatactcg aaaatctctt caaatcacgt
     7441 caacgtcgcc ttgccgtagg tatggttact gacttcgtca gttctatcca caacctcaaa
     7501 acagtatttt gagctgactt cgtcagttct atccataact tcaaaacagt attttgagct
     7561 gacttcgtca gttctatcca taacttcaaa acagtgtttt gagcaacctg cggctagttt
     7621 tctagtttgc cctttgattt tcattgagta tcaaaaagca agccattttt ggcttgcttt
     7681 tttcatcttt aaaagtgatt ggcctgctta acgaggtggt agtccaaggg caatacggcc
     7741 atagcgactg attcgtgtga ttttccaagc aggcgaccag gtaacttcaa ccttgatatc
     7801 tttgataccc tcgatttgtt tcagacctgc cacaatttca ataggcaggc tttcggcgca
     7861 atcacaggca gtatcggtga aggtcatgac aatcttgcag agccccgttt catccagatt
     7921 gatttcataa atcagaccta gattgtaaac atccaattcc acatctgtat caaaaacttt
     7981 ctctagtttt tcgataattt ggtcttgcaa ggccaaagca cggtcattga ttttgatatc
     8041 gtctctcata gcagtccctc cacgtgataa atatcctcta ttttctcata attctgacaa
     8101 tttggcaagt ttttgatgaa ttttctgaaa aatatgataa aatgaagaaa atacggaatc
     8161 aaggggaagt ctatggagta gattggaaaa gtctttagac aattacgaga atcaagaaat
     8221 atctcactga gacaagcaac cggaggacaa ttttcgccgt ctatgttgtc ccgttttgaa
     8281 acaggtcaga gtgagctttc ggtggaaaag tttctatttg ctctggaaaa tatatctgcc
     8341 agtgtggagg agatcctctt tctggcgaga ggtttccagt atgatacaga ttctgagttg
     8401 agaaaagaaa ttacagatgt cttggaacca aagaatatag cacctcttga ggacttatat
     8461 cgcagggagt atcaaaagca tgcccattct cacaacaaac agaaacatat tctaaatgcc
     8521 attatgatca agtcttatat gaagagcata gatgaaaggg tagagttaac agcagaggaa
     8581 ggaaaagtcc ttcatgatta tttgttttct accgagatct ggggaatcta tgaactcaat
     8641 ttattttcag tcagttctcc atttttatct gtttctcttt ttactagata tgtacgagaa
     8701 atggtacgta aatctgattt tctaatggaa atgtctggca atcgaaacct ttttcatact
     8761 atactattga atggcttttt agctagtatt gagtgtgaag aatttaccaa tgcctattat
     8821 tttaaacgtg ttatcgaaga gcatttctac aaggaaaatg agacctattt ccgaattgtt
     8881 tatctgtggg cagaaggttt ccttgatagc aagcaaggta gagtcaagga aggtcagaaa
     8941 aagatggagg atgctgtccg tatttttgag atgcttggct gtaataaatc tgccgaatac
     9001 tatagaaata cgaccgaatg ttgaatatct gcaaaccaag aaaaaatttg aagcgataga
     9061 actgttgccc tctctcaggt cattacaaaa gttctatcgt ttttttgctc attttgtttg
     9121 ttgcatatat tcaaaagaat cgtttcgcaa attcataagt gctatactaa agctattctt
     9181 gatgtagaac ttagaacaag gagggagatt atctatgaaa ctattgttta gaaatccagc
     9241 ttatagaatt ttgactttat cacgcttctt caatgctttt ggtgcttcga ttttcaacct
     9301 ggtctttatc gtctatgcat cgaccttgtc acaagcatct tttgctgttg ctatggcgaa
     9361 tattgtcatg attcttccga ccctctttac agtttttgca gggattcggg cagattacac
     9421 gagggacaag gtcaaatgga tggtctatag cggtttgttt caggcggttc tattttttct
     9481 agcagcccta gttgttcagc aagctagcct ctttgccttt tctagcctgt gtttgatcaa
     9541 tgtcattagt gatatcatca gtgattttgc aggtggcctg cgtatgcctc ttattaagga
     9601 aaaagtagct gaagatgatc tgatggaggc ttattctttt tcacagttca tcacctatat
     9661 ttcagctatt ggtggtcaag ctttcggagt ctggctctta gctctatcgg tcaacaattt
     9721 ttctctcgtt gcgggaatca atgcctgctt tttcctagta tcagccacta tcctcttttt
     9781 aggaaaaagc aaattgagcc tgtcaatgtc atctgctgat ggtgaaaact taaaaaatga
     9841 gaagctttct atcaaagacc agttcctaac aatttaccga aatttacgtc tcgtttttct
     9901 taaaagtgga cagaaaaact ttggttttat gctctttgct gtcttgctta ttaattcctt
     9961 gggtggcgct ttgggtggaa tttataatat cttctttttg agccattctc tcttgaattt
    10021 ttcttataca gaggcactat ttatcaatca attctgtgtt ttagtagcaa tcatcatcag
    10081 tagccttacg ggcaatgatt attttgggaa gcagtccttg cctagattga tgatgtgggc
    10141 gaccgtagga cttagtctag ttggtttggc taatttattc aatcaagtcg tgcttggttt
    10201 gctatttctc ttctttactc tgtatgtgtc tggtaaagtt caaccaaaga ttagtgccat
    10261 gctcatgaaa aatctagctc cagaggttct agctcgtact agtaattttt tcggtctatt
    10321 gtttacctta tccatacctg tgggaacagc ttgtttttca ctagtagccg tatggaacat
    10381 gcagttgact tggatgctat ttgttggttt ttccttgcta gctatttttt tgacaattct
    10441 taatctcaaa aatgatattt gaatcctaat tttttctcac tgttttaatc cctctattta
    10501 tggtaaaata agactattaa gtttaaagag gattccctat gaaattacaa aaaccaaaag
    10561 gaacgcagga tattttacct gctgagtctg ctaagtggca gtacgttgag ggctttgccc
    10621 gtgaaatttt caaacgctac aactacgcag aagtgcgtac gcctattttc gagcattacg
    10681 aggttatcag tcgctctgtc ggagatacaa cggatatcgt aaccaaggaa atgtacgatt
    10741 tttatgacaa gggtgaccgt catattaccc tccgtccaga aggaactgcg cccgttgtcc
    10801 gttcctatgt ggaaaataaa ctcttcgccc cagaagtgca aaagccaagc aagttctact
    10861 atatgggacc tatgttccgt tatgagcgtc cacaggcagg gcgcttgcgc caattccacc
    10921 agattggtgt tgagtgtttt ggctctagca atccagctac cgatgtggaa acaatcgcta
    10981 tggcagccca ttttttgaag gaaatcggta ttcaaggtgt caaattgcac ctcaacactc
    11041 ttggaaatcc tgagagccgt gcagcctacc gccaagcctt gattgactat ttgacaccgc
    11101 tcaaggagac cttgtctaag gatagccaac gtcgcttgga ggaaaatcct cttcgtgtct
    11161 tggactctaa ggaaaaagaa gacaaggtgg cagtagagaa tgcgccgtct atcttggact
    11221 ttcttgatga agaaagccaa actcattttg atgctgtgcg tcagatgttg gaaaatcttg
    11281 gagtagatta catcatcgat accaatatgg tgcgtggtct ggactactac aaccacacca
    11341 ttttcgagtt tatcacagag attgagggca atgacttgac agtctgtgcg ggtggtcgct
    11401 acgatggttt ggttgcttac tttggaggcc ctgaaactgc tggatttggt tttgggcttg
    11461 gtgtagagcg cctgcttctc atccttgaaa aacaaggcgt ggccctccct atcgaaaacg
    11521 ccctagatgt ctatatcgca gtcttgggtg atggagcaaa tgtcaaagcc ctagaactag
    11581 tccaagctct tcgccaacaa ggtttcaaag cagagcgtga ttacctcaac cgtaagctca
    11641 aagctcagtt caagtcagca gatgtctttg cggctaagac cctcatcacc ctaggagaga
    11701 gcgaagtcga aagcggacaa gtgacggtca agaacaacca aacccgagaa gaagtgcaag
    11761 tgtcacttga gacaatcagc caaaacttct cagaaatctt tgaaaaacta ggattttata
    11821 ctcaatgaaa atcaaagagc aaactaggaa gctagccgca gattgctcaa aacactgttt
    11881 tgaagttatg gatagaactg acgaagtcag ctcaaaacat ggttttgagg ttgtagatga
    11941 aactgacgaa gtcagtaacc atacctacgg caaggtgaag ctgacgtggt ttgaagagat
    12001 tttagaagag tattaatgat agataaagtg gtcaggaact tactcctgac ctttttcttt
    12061 tgcaaaatga caaaaatcat aaactttttg acaactataa ttgtcaaaaa agaaaaagat
    12121 atgttacaat gaattcaagt taagaaatag gaagcagaaa ggagttataa tgtgggtact
    12181 aggatttata ctatttatga ttttctttta ttctaataat tctaaaaaaa tcaagaaact
    12241 agagaataaa atcaaaaaac ttgagcgaaa agagaaagga aacgcagaaa tgtcgagatt
    12301 attacaagaa atgattggaa aggaaccaat tataacggga gtgtatattg ggccagataa
    12361 ctgggaagtt gtggatgttg atgaggaatg ggtcaaacta cgtagtgttg ataatacggg
    12421 aaaagaaaaa ttcaagttgc aacgtattga agatatccaa accgttgaat ttgacggaga
    12481 gtaggtgtgt aacgtgcaac taaaaaatcg tctaaaagag cttcgagctc gcgatggtct
    12541 caatcaaacc gacctagcca aactggcagg ggtttccaga cagaccatta gcctactaga
    12601 acgggatgag tacaccccat ccattatcat tgccctgaaa atatctcaaa ttttcaacga
    12661 aacagtcgaa tcggtatttc gtttggagga ggacgagtga tgaacaagta taaagtgatt
    12721 tattatgtag tggtcatagc tttattagtc agcgtatttc tactgattgg gatggaccta
    12781 agctggttta atccctatca aagcgaccaa tttgtttggg tctactttgc tctcatccca
    12841 gtaactgaat ggattgaaaa gaaatccaaa aatctagcaa gtgaaaaagg agaatgaata
    12901 tgaaaaagaa acgtagattg ttatttttga tgtctattgt cttggggggg gtcttgggca
    12961 tgtttgtagg gatgtttaag gcacgtgtcg aatcccacga aattatttta gatgtaaaag
    13021 ccttgatgcc atggatatca gctatttgtt tactgatagg tttcattagt atgtttttga
    13081 ctttcaattt cttaaagaaa agcagaaaat ttcattcctt gtatcaagag gaaatggatg
    13141 acgatctgaa tgaaacctat tatgtgcaaa tgtatcggaa tcttgagttt ggaaccattg
    13201 cttttaatat tacaggtgta gcgattccat tggctatttt tatttcatta agtgaggtga
    13261 ttatattgca tacaaaccct caaacatttt tcctttcttt cttactcttt gtggtattct
    13321 tagtcgctca aaaatctctt tttaaaacca ttgcgattgt tcgtcagttt gatttggaat
    13381 ttttcgctac accaaaggat gtcttgaact atataaattc ttatgatgaa ggggagcgtc
    13441 aggctaattt ggaacagagt tttcgaattt tattccaatt acaccaatat gtcttaccag
    13501 ccttatatat ttttcttatt atcatttctt tcttgacagg agagattcag ttactagctt
    13561 tcttgcttgt aggagccatc catgtttata tcaatgtgat gcagttacct atggtaaaac
    13621 gttatttcaa ataaaggagt tatctatgaa attacttaaa aaccttggct ggattcttct
    13681 agcccttcta tcctttttct ttatctatgg ctttattcag gggctcgcga ctgcgtcgct
    13741 tgctttaggc gcttcaccct atgctgttac tctactctat gtggtcttgg ctggagtata
    13801 tgtgtacggc atttacaaat ggtatcagaa agctcctgtt tatattgaga agagcggctt
    13861 taaccgattt atttggcttc ctgccttggt ttggttctta tctctggtcg ttcaattctt
    13921 cttgccagat gatccttcag taaatcagca aatagcgaca gacttgacct tgtctcaacc
    13981 acttttctca ttctttgctg tggttatttt tgctcctttg acggaagaga ttgtttttag
    14041 agggatgtta gcacgctatc tctttcctaa gcaggacaat agtaaacgaa ccctgatttt
    14101 tcttctggta tctagtcttc tatttgcctt gattcatttt ccaggtgatg tgcaacaatt
    14161 ttttgtctat tttagccttg gttttagttt gggtttggct tacgttagca gaaaaggtct
    14221 ggtctacagt atttctcttc acgctttgaa taatttagtc ggctttttga tgattctcat
    14281 gctataatag agtcaggagg tcacatgaaa cgagtaattt tattagcagt gattcaggca
    14341 gtcgttctat ttttcatcat tggagcgcta gcttatgcct tcaaaggcga tttcttctat
    14401 aactatctag cagttgtctt tgctcctatt gcaggtgtac tgcgttttgg gacggcttac
    14461 ataacggaaa ttgtcttgcc tcgaaaggca gccgaaatcg ctgaaaagcg taaagcaggc
    14521 aaaaattcaa aataaaagag tccggtgaag ttcatcggat ttttgtatta tactcaatga
    14581 aaatcaaaga gcaaactagg aagctaaccg caggttgctc aaaacactgt tttgaggttg
    14641 tggatgaaac tgacgaagtc agctcaaaac atggttttga ggttgtagat gaaactgacg
    14701 aagtcagctc aaaacatggt tttgaggttg tagatgaaac tgacggagtc agtaaccata
    14761 cctacggcaa ggcgacgctg acgtggtttg aagagatttt cgaagagtat tagcgctaat
    14821 ttttagggct ttcacctgac ttttaaagac tggcaaactt ttctgatgat tttcatgaag
    14881 agcctgcgct tttatggtaa aatagtaaca gaataaaaga ggagagaaat aatgaaacgt
    14941 agtatgtatg ctggtcgtgt tcgtgaggaa cacatcggac aagaaataac cttgaaagga
    15001 tgggttggcc gtcgtcgtga ccttggtggt ttgatcttta tcgatcttcg tgaccgtgaa
    15061 ggaatcatgc agttggttat caaccctgaa aaagtatctg cagaggttat ggcaacagct
    15121 gaaagccttc gtagcgaatt tgttattgag gtgactggtc aggtcgctgc gcgtgagcaa
    15181 gccaatgata agttgccaac tggtgcggtt gagttaaacg tgacagctct tattgtgctt
    15241 aacacagcta agacaacacc atttgagatt aaggatggca ttgaggcaaa tgacgataca
    15301 cgtttgcgtt accgttacct tgaccttcgt cgtccagaaa tgttggaaaa tcttaaactt
    15361 cgtgccaagg tgacccactc tatccgcaac tatttggatg agttggagtt tatcgacgtg
    15421 gagacaccat tcctttctaa gtcaacgcct gaaggggcgc gtgattattt agtgccgtct
    15481 cgtgttaata aggggcattt ttacgctctt cctcaaagtc cacaaatcac gaaacagctc
    15541 ttgatgaatg ctggttttga ccgttactac caaatcgtta aatgtttccg tgacgaggac
    15601 ttgcgtggag accgccagcc tgaatttact caggtcgact tggaaacgtc cttccttact
    15661 gagcaagaaa tccaagatat tacagaaggc ttgatcgcgc gcgtgatgaa ggaaacaaaa
    15721 ggcatcgaag taacgctacc attccctcgt atgaaatacg atgatgctat ggctctttac
    15781 ggttctgaca agccagatac tcgttttgac atgttgcttc aggacttgac agaagtggtc
    15841 aaaggtgtag actttaaagt cttttcagaa gcacctgctg taaaagcgat tgtggtcaaa
    15901 ggagctgcgg acaactattc acgtaaagac atcgacaaga tgacggaagt agccaaacag
    15961 tatggtgcca aaggtcttgc ttgggtcaag gtggttgatg gagaattaaa cggaccagtt
    16021 gccaagttct tgactggtat ccaagaagaa ttgacaacag cgcttgctct tgaagataag
    16081 gacttggttc tctttgtggc ggatacgctt gaagtggcta atgcaacact gggtgccctt
    16141 cgtggacgta ttgctaaaga gcttggcttg attgataatg ataagttcaa cttcctttgg
    16201 gtggttgact ggccgatgtt tgaatggtct gaagaagaag gccgctacat gagcgcccac
    16261 catcctttca cccttccaca ggaagagact gctcacgaat tagaaggtga tttggctaag
    16321 gttcgtgcca ttgcttacga tatcgtcttg aacggttatg agcttggtgg tggtagcctt
    16381 cgtatcaacc aaaaagacct tcaagaacgc atgttcaagg ctcttggttt ctcagctgaa
    16441 gaagccaatg accagtttgg tttccttctt gaagccatgg actatggttt cccaccacac
    16501 ggtggtttgg ctatcgggct tgaccgtttt gtcatgttgc ttgctggaga agaaaatatc
    16561 cgtgaagtca ttgcctttcc taagaacaac aaggcaactg acccaatgac acaagctcca
    16621 tcaacagtcg ctctcaaaca actagaggaa ctcagcttac aagtagaaga agatgaaaca
    16681 agcaaaacga attaagcggt ggcgctatta tctgcgccgc tttgcttatc agataaaaat
    16741 tttacgtgtc ttacaaagta tctctcgaga aaagtatgat gagaagattt cggcctctct
    16801 ggtctatggt tttttatcag cagtagcagt taatttcttt ttccaaccag ggcatgtgta
    16861 ttcgagtggt gcaacaggtc tggcacagat tatctctgcc ttgagtaatc actggtttgg
    16921 ttttcatatt ccgatttcgc taagcttcta cgccattaac ttccctttga tggtcttagc
    16981 ttggtatcag attggccata agttcaccgt ctttaccttt atcacggtat ctatgagttc
    17041 cttctttatc cagtttgtcc ctgtggcaac cttgacggag gatcccatta tcaattccct
    17101 ttttgggggt gttgttatgg gtttggggat tggttttgct cttcgaaaca atatctccag
    17161 tggtgggacg gatatcgtca gcctgactat tcgtaagaaa acgggtaaga atgtcggtag
    17221 tatttctttc ttggtaaatg gaactatcat gctgatagca ggtttgacct ttggttggaa
    17281 atacgctctt tattctatga ttaccatctt tgtctctagc cgtgtgacag acgcagtctt
    17341 tactaagcaa aagcgtatgc aggccatgat tgtgacaaat catccagaga aggtaattga
    17401 aaaaatccat aaaaaattgc accgcggagc aaccatgatc cacgatgcag aaggaaccta
    17461 taatcacgag agaaaggcag ttttaatcac tgtcattaca cgtgcagagt ttaatgaatt
    17521 taaacagatt atgacacaag tggatccaag ctcctttgtc tctgtctcgg aaaatgttca
    17581 tattctagga agatttgttg agatagataa ttagtgatta atactcttcg aaaatctctt
    17641 caaaccacgt cagcgtcgcc ttgccgtata tatgttactg acttcgtcag ttctatctgc
    17701 aacctcaaaa ccatgttttg agcaacctgc ggctagcttc ctagtttgca ctttgatttt
    17761 cattgagtat aaaaagatct tgggaaaaga ctcaatttca gtagaaaagg aagtaaatct
    17821 tcccacaata aaacgcatag tatcaagttt tttcaatacc tgatagtatg cgtttttgct
    17881 tttaacgact ctttgcccag tctcttattt ttcgataatt ttgtgggcga tcaattgacg
    17941 gtaacaaatt tgtttattgt ttttattatc attaataatc tggagaatag tttcaaggga
    18001 aacacgacca agctctaaac tattgatatc gacataggct gccaagttga gcttgggatt
    18061 aaccgagtca aagctgagaa cagggacatc cagctggtgt ttggcaatat agttacaaac
    18121 accttcagct aggaggctat cggttgtgat gatagcatca atttgtggat cgtgcttgaa
    18181 taatcgcttg ctaaatttat agcccttttc ttccagaaac tcgtcggcaa agtagatgcg
    18241 attgttgtca gtggtaagtt tgtaatgttt aagcgcctgt tcatagcctg ttaaacggtc
    18301 tttggtcacg aagagctttt tacttcctcc gataaaggca atgcgtttgc agcctttttt
    18361 gatgaaatat tcagtcgcat caaaaccagc ttgaacattg tcgttgtcga caagtgggat
    18421 gaaaggagat agagatttac ctaagataag gaaggggaac tgttcttctg cgacgagttt
    18481 tacgagaggg tcttcttctt gggcatagag aaagattagc ccatctacac gcttgccgta
    18541 gaccatttgt gaaatagcgt tgagacgctc cttctcatct ttccctgttg ctatctgaat
    18601 ggcatagtgg ttttcagatg cgacttgaga gatgccacgt agaaccgatg gaaagaaagg
    18661 attctggtag aaggcgtctg agtcatcagg aagaactaat ccgataacct gagtatagct
    18721 gcttaccaag ctacgagcgt tgaggtttgg gtggtagttg agttccttca tagctttgcg
    18781 aacgcgtttt tttgtttcgt cgctaatggt tgatttattt tgaataacac gggttacggt
    18841 tgaaggcgaa acaccagcag ccttggccac gtctttaatc gtaacgggca taaaaatctc
    18901 ctatttatgg taatttggat cacggaaatg tgttttataa aagatagtga ccagatacag
    18961 aacaaaaaga atattttgta cagtaatcag ggttgtcata ttttggccaa ataatcccaa
    19021 aataagtgta atcagagtcg gcaatcctaa acagttcaag ataaagtgat agcactcttt
    19081 aaaggttcta aatgaaaaga ggcgtgattt cttagtgata taaaggagaa gactagctcc
    19141 tagagagacg ataaagaaat tcaaaccaaa gaggaagctc gcaccgagaa ctaggaagag
    19201 gctgatatag acacgatttt gttggtacca gtctttagaa attgcttggg tcaagctgtc
    19261 tttgcttttg aaactctcag tctgaatggc tcggtaagag atgcgggtca gctccttgct
    19321 ttccttgctg atgactagct catttgtatc gaaatgcagt tgcaagtcct taggtaattc
    19381 cttgatttga cttggaccaa tcacaacaga aggggtttga ctagctgttc cagtataagt
    19441 taatgtgcca tcgacaattg tagcatgttc agagagatcc tggacaacct catttgtcag
    19501 aggttcatag acattatcga taaaagtttc tagcggatag gtctcctggg agctgttttg
    19561 gatagcaatg ggtaccatag acaagctgat aaggaagata ctggtaaaga gaagttgaaa
    19621 ccagttgagc tcgaaacgtt tggacagggg cttacgaaac ccccaaatac ttgaaaaata
    19681 ggaaaatgga tatggaagca taggtatctt tctaaaaggt gttttctata tgagtattat
    19741 tatatagaga aatgcgcttt atttcaagtc taggagaaaa attgcttgct acaaggatat
    19801 tatttacagt aacaattgct aataatcaat gaaaatcaaa gtgcaaacta gccacaggtt
    19861 gctcaaagca caactttgag gttggagata aagctgacgt ggtttgaaga gattttcgaa
    19921 gagtataaaa tgaaaaaggg tggcggggat aaattatccc ttgtcgccac cacttgtaag
    19981 tcctgaaaca aagttctttt gtaggaagaa gaagagaata cagattggaa gggcgatgag
    20041 gatagcacct gctgagaagt aggcaatctt caagtttttc gcattgttaa cgaaggtttg
    20101 gagacctacg gcaacagtaa agtattcttt ctcacgaagc aagaaactag agaggatgta
    20161 gtccccgaaa ggtcccatga aggcccagag agcttgtacg gcaaccattg ggcgaacaag
    20221 tggaagaaca atttgccaga agcggcggaa gtgtcctgca ccgtctagtt ttgcagattc
    20281 gtctaaagac attggcactg tatcgaagta gcctttcatg agccaagcat tcatcgggat
    20341 accaccacca acgtagagga agatgaggaa ccagctgtgg ttaagggcgt tcaacataag
    20401 cgccataacg aagaaggctg tcaaagcggc catagttggc accatttgga tgatcaagaa
    20461 gaagaccaaa ctttgtttac gagccaagaa gttgtaacgg ctgtaggcat aaccagcaag
    20521 tacgatgata cttgtttgaa cagccatggt aattaaggcg ataatcaaag tgttgaggta
    20581 ccaagtaccg tacaaggttt cagtgaagag gcctttaaag ttatcaaaat tgaggtcgat
    20641 attagtatct agtttaaagg ctgagacgtt acctgcttta aaggctgaca taatggtaat
    20701 caacagtgga tagataatta caattgatag accaatcagg taaaggtaag taaggctttg
    20761 agtcagtcta cgtttgagtt taattgagtt attcatctta gacgtcctcc atatcaaatg
    20821 cgtgtagttt cttgaatgcg atcatagaga ttgagatgac aatgatagag ataatcaagg
    20881 taacagctgc cgccattgag tattgaggag atgtacctgt tgtcaaacgg tagatccatg
    20941 agatcaagat atcggttgaa ccagctccac ctccgacact accaggtcct ccaccattga
    21001 agaggtacat gatagagaag ttgttaaagt tgaaggtgta ttggctaatc aaagtaggtg
    21061 ccgcaacagc caaaatcatt gggaaagtga tgttgcggaa tttttgccaa gcgttggcac
    21121 cgtcaatata agctgcttcg taaaggtcgt taggaataga ttgcaagata cccaaagtca
    21181 aaacgtagat gtatgggaat ccgagccaac cttgcatcat aatcaaggca atcttagtcc
    21241 aagttgggtc tgttttccaa ggaataagag ctccatcaag gaaaggaagg aatttagcca
    21301 agattggcaa tacttgagtg ttgatagcac cgacactatc gttaaacatg tttgagaatg
    21361 tcaagatagt gatgaaggct gggacagccc aaggaagaag gaaaataaca ccaaagatac
    21421 gttttccttt gataaatggt tggttggcaa tgatagctgt gaagatacca attacgattt
    21481 gtaaagtaga agctgccaaa gcccaaatga tagtccaaga aagaacagaa ccaaaggcag
    21541 aacggaaggt actcaagctc caaatgtttg taaagttggt caaaccaacc cagtccaaca
    21601 acttgtttgg tggcaagtgt tggaagtcgt agttggtaaa ggcgatcatc aaggttacga
    21661 taactgggaa gataatcgcg aaggtcatgg caacataaga tggaatgatc aagaggtaag
    21721 ggaagccatt ttcataaatc cctttgatca tgtctttgag tgtgcgtgga actggaattc
    21781 cattgttaat gcgttttgca atcgtatgtg catctttgat atttgagaaa taaaagagta
    21841 cataaacgat tacaaagatt agatggaagg caccacgaat cagcataaag agggaattat
    21901 cacgacctgg tttgtcacca agagtgatga ggttgctcaa ttcaggggtt gcaagtgcta
    21961 ggaagtaaag gacaaatacg atggttacac caaggaagat aaaacctttg gctttttgtt
    22021 tattgtaaat ctgtcctaac ccaggaatga tagacagcag ggctgcttta ctaggttgtt
    22081 gcttttccat attaactcct ttcataggat actacttttt tataagaaag ctaaattatt
    22141 tgtgtctcta ttgataaatt caaaggggga tttgatttcc accccccttg aacaaatttt
    22201 ttattcacca aatttttgtt tgattgtttc tttgatcaat gttacagcat cgttagcagc
    22261 tgttttagca tctttttgac cacttacagc atcaaagagc atatttttcg ctggatccca
    22321 aactgcagac atttgagaga tgtttggcag tggttgagtg ttcttgaact gtttgataac
    22381 agctgttgtc aactcatcgt ttttaccttc agcgtatgaa cgagcctcag tattagctgg
    22441 gatttcgtta gtcttatcat ataatacttt ttgttgttca gttgcaacaa ggaagtctac
    22501 aaatttttga gaagcttcaa ggttcttaac ggcttgagga atgacccaag ctttaccacc
    22561 accgaatgca gcatattctt ttccatttgg aagagttggg atagttgcaa ctccgtagtt
    22621 tactttagca tctttaaagg cttgagcttt ccaaggtccg tcgatgatag cagctgtttt
    22681 accttcttgg aattgagttt ggattaagtt tccagcacct tctgtatctt gcataccttt
    22741 aggccatttt tcgtaccaag atttagcgta gttgatacct gcgatagaac cgtcgtttgc
    22801 aagaccgatg tctttagcgt ctttaccgtt ttggccaaag acgtaagcac cgttaccggc
    22861 aagaagtcca tatgtatagt agaagtttgt ccagtcagct aggaaggcag tagttttacc
    22921 atcttcacca gcgaatgcgt atttgctatc tttagcaagg ttttccaagt cagcaaatgt
    22981 ttttggagca tctttcacca agtctttgtt gtagtacata acaagtgact cgataacggc
    23041 aggagcaccg taaactttac cattagcagc tgttacaaga gatttagttg tgtcgtctgt
    23101 tttagcacca tcgctcaatt tcacttctga aagttgtccg tcagaaccaa ggctacctac
    23161 acggtcgtat ggagccatca taacatcagg gacattacca gattggttgt caagagaaag
    23221 tttatcaaga cctcctagag catcaccagt tttaagagtg acttttactc cagcttcttt
    23281 ttcataagct ttagcaacct cttcaatata gctcttatat ccctcgtcta catatacagt
    23341 gagttctttg acttcagatg aaccagaatc agcaggctta tcagcagttt tgcttccgca
    23401 agctaccaaa agcaagctag caagtgtagc agttccaagc accgcagtgc tcttcataaa
    23461 tttagatgac atagtgtatt cctcccaaag aatagcaagt tttattgata aggaaacgca
    23521 aacgttttcc tttatgagct tagtatagca caaatagaaa acggttgcaa gtattttttg
    23581 taaaaatttt aaaaaatttt taagcttgat ttgatagcat aattttgcat tttaatagaa
    23641 gaaaagtatg aaatagataa gaatacagta tttttaataa aaatatatgg aatctgtcta
    23701 aagagggaaa tcaggagggg ctacctccct gtttctaatc cctatctatt ttctatagac
    23761 gtttgtgctt tgttgcatat aaattcaagc tccctaagga ggttttgtac tttgtagact
    23821 gtctcgtgag agtcaaactt taggattaga tagttttaag ttatctttgc taaaatgagt
    23881 tagtctcctt aaaaataatc aaaaaagttt tttaaaaacg cttgcaatta tgcttgaaaa
    23941 ggagtatact tataagtaac gcaaacgttt gcgtctgcaa aatacgcaac gttccattat
    24001 tttaacacac gaggtgctat tatgaaaaaa cgtcaaagtg gtgtgttgat gcacatctct
    24061 tctcttccag gagcttacgg aatcggatca tttggtcaaa gtgcttacga cttcgttgat
    24121 ttcttggtcc gtacaaaaca acgttactgg caaatccttc cattaggagc aactagttac
    24181 ggggattctc cttaccaatc tttctcagcc ttcgcaggaa acactcattt tatcgattta
    24241 gatatcttgg tggagcaagg tttgttggaa gcaagtgacc ttgaaggagt tgactttggt
    24301 agcgatgcgt ctgaagttga ctatgctaaa atctactatg cacgtcgtcc tcttttagaa
    24361 aaagcggtga aacgtttctt tgaagtcgga gatgttaaag attttgagaa atttgctcaa
    24421 gacaaccaat catggcttga gctctttgct gagtatatgg ctatcaaaga gtattttgac
    24481 aatcttgctt ggactgaatg gccagatgca gatgctcgtg ctcgtaaagc ttcagcactt
    24541 gaaagctatc gtgagcaatt ggcagacaag ttggtttacc accgtgtgac tcaatacttc
    24601 ttcttccaac aatggttgaa attgaaagct tacgctaacg acaaccacat cgaaatcgtt
    24661 ggggacatgc caatctacgt agcggaagat tcaagtgata tgtgggcaaa tccacatctc
    24721 ttcaaaacag atgtcaatgg taaggctact tgtatcgcag gatgcccacc agatgagttt
    24781 tctgtaactg gtcagctttg gggtaaccca atctatgact gggaagcaat ggacaaagac
    24841 ggctacaaat ggtggattga acgcttgcgt gaaagcttca aaatctacga tatcgttcgt
    24901 atcgaccact tccgtggctt cgaatcttac tgggaaatcc ctgctggttc cgatacagca
    24961 gcacctggtg agtgggtgaa aggtccaggc tacaagcttt ttgcagccgt taaggaagaa
    25021 cttggtgagc taaacatcat cgcagaagac cttggcttca tgacagatga agtgatcgaa
    25081 ttgcgtgaac gtactggctt cccaggaatg aagattcttc aatttgcctt caacccagaa
    25141 gacgaaagca ttgatagccc acacttggca cctgctaact cagttatgta cacaggaaca
    25201 cacgataaca atacggttct tggttggtac cgtaatgaga ttgatgatgc gactcgtgag
    25261 tacatggctc gttacacgaa ccgtaaagaa tacgaaacag tggtacacgc tatgcttcgt
    25321 acagtatttt catcagttag ctttatggca attgcaacta tgcaagattt actagaattg
    25381 gatgaggcag ctcgtatgaa cttcccatct acccttggtg gaaactggtc ttggcgtatg
    25441 actgaagatc aattgacacc agctgtcgag gaaggtttgc ttgacttgac aacaatttat
    25501 cgccgaatta atgaaaattt ggtagattta aagaaataag acaataatca ggagacaact
    25561 aaacatgtta tcactacaag aatttgtaca aaatcgttac aataaaacca ttgcagaatg
    25621 tagcaatgaa gagctttacc ttgctcttct taactacagc aagcttgcaa gcagccaaaa
    25681 accagtcaac actggtaaga aaaaagttta ctacatctca gctgagttct tgattggtaa
    25741 actcttgtca aacaacttga ttaaccttgg tctttacgac gatgttaaaa aagaacttgc
    25801 agctgcaggt aaagacttga tcgaagttga agaagttgaa ttggaaccat ctcttggtaa
    25861 tggtggtttg ggacgtttgg ctgcctgctt tatcgactca attgctactc ttggtttgaa
    25921 tggtgacggt gttggtctta actaccactt tggtcttttc caacaagttc ttaaaaacaa
    25981 ccaacaagaa acaattccaa atgcatggtt gacagagcaa aactggttgg ttcgctcaag
    26041 ccgtagctac caagtaccat ttgcagactt tactttgaca tcaactcttt acgatattga
    26101 tgttactggt tatgaaacag cgactaaaaa ccgcttgcgt ttgtttgact tggattcagt
    26161 tgattcttct attattaaag atggtatcaa ctttgacaag acagatatcg ctcgcaactt
    26221 gactctcttc ctttacccag atgatagtga ccgtcaaggt gaattgctcc gtatcttcca
    26281 acaatacttc atggtttcaa acggtgcgca attgatcatc gacgaagcaa tcgaaaaagg
    26341 aagcaacttg catgaccttg ctgactacgc agttgtccaa atcaacgata ctcacccatc
    26401 aatggtgatt cctgaattga ttcgtctttt aactgcacgt ggtatcgagc ttgacgaagc
    26461 aatctcaatt gttcgtagca tgactgccta cactaaccac acaatccttg ctgaagcgct
    26521 tgaaaaatgg cctcttgaat tcttgcaaga agtggttcct cacttggtac caatcatcga
    26581 agaattggac cgtcgtgtga aggcagagta caaagatcca gctgttcaaa tcatcgatga
    26641 gagcggacgt gttcacatgg ctcacatgga tatccactac ggatacagtg ttaacggggt
    26701 tgcagcactc catactgaaa tcttgaaaaa ttctgagttg aaagccttct acgaccttta
    26761 cccagaaaag ttcaacaaca aaacaaacgg tatcactttc cgtcgttggc ttatgcatgc
    26821 taacccaaga ttgtctcact acttagatga gattcttgga gatggttggc accatgaagc
    26881 agatgagctt gaaaaactgt tgtcttatga agacaaagca gctgtcaaag aaaaattgga
    26941 aagcatcaag gctcacaaca aacgtaaatt ggctcgtcac ttgaaagaac accaaggtgt
    27001 ggaaatcaat tcaaattcta tctttgatat ccaaatcaaa cgtcttcatg agtacaaacg
    27061 ccaacaaatg aacgctttgt acgtgatcca caaatacctt gacatcaaag ctggtaacat
    27121 ccctgctcgt ccaatcacaa tcttctttgg tggtaaagca gctccagcct acacaatcgc
    27181 tcaagacatt atccatttaa tcctttgcat gtcagaagtt attgctaacg atccagcagt
    27241 agctccacac ttgcaagtag ttatggttga aaactacaac gttactgcag caagtttcct
    27301 tatcccagca tgtgatatct cagaacaaat ctcacttgct tctaaagaag cttcaggtac
    27361 tggtaacatg aaattcatgt tgaacggagc tttgacactt ggtactatgg acggtgctaa
    27421 cgtggaaatc gctgagttgg ttggagaaga aaacatctac atcttcggtg aagattcaga
    27481 aactgttatc gacctttacg caaaagcagc ttacaaatca agcgaattct acgctcgtga
    27541 agctatcaaa ccattggttg acttcatcgt tagtgatgca gttcttgcag ctggaaacaa
    27601 agagcgcttg gaacgtcttt acaatgaatt gatcaacaaa gactggttca tgactcttct
    27661 tgatttggaa gactacatca aagtcaaaga gcaaatgctt gctgactacg aagaccgtga
    27721 cgcatggttg gataaagtca tcgttaacat ttctaaagca ggattcttct catctgaccg
    27781 tacaatcgct cagtataacg aagacatctg gcacttgaac taatactctt cgaaaatctc
    27841 ttcaaaccac gtcagcttta tctgcaacct caaagcggtg ctttgagcaa cctgcggcta
    27901 gcttcctagt ttgctctttg attttcattg agtataagat acaaatttat actaatacat
    27961 cttgtaaaaa agcgagtttc gattgaaatt cgctttttta aatgctgtgg atttgggtca
    28021 atcttgtcta aaaataggga aatcctagat acagtgaagg ctttaaatgc tggtttttac
    28081 tgtcttcagc cttatatttt ttcgtagttg gttacctcat atctcttgta ttcgcttaca
    28141 taaagtatta taatataatt gtaggaaaga aggtgttttt atgatataca cacttaaatt
    28201 ggtgttgttt attacctttc ttgtaataag cttgttacct gataagattt ttggaaaaaa
    28261 taaaaaaatt cggaaaatag tttttgcaat attgacggca gtggcagcat tgtcatttat
    28321 gtactaagtt attttaagaa tgtagggaaa taaaccctac attcttttta gttttttctg
    28381 ttttctaaat tctatttatc caagcgcttc aacatttctt gcttcttcgc ttcaagttct
    28441 gcacgctttt cttcgatttc ggcatgtttt ttctcgagtt cagaacaact tgcatcattg
    28501 ctaaattctt ttcgccatca ggagataggg tgagtcgaca tgtctattac tcacccaaag
    28561 cagtcctaca aagcaggaat tttctgttac ttttttggaa atagtaacgt ttatacagct
    28621 ttgacacttc gtatcaaagc gccaaacaca ctccgaggga tttacagaaa gcagaaaagg
    28681 aatgatctgg tataagatca ttccttttct ctctttttta tttgtatctg cttacatttt
    28741 atcatatact gttattatag tcaaaaaaat atgctattat gttaaaaaaa tatttttcaa
    28801 aatataaatg gacggattta ttttggattt tatttgttat tttgacctgc ctctatattg
    28861 gtaaccatga tttgtttact ctcaatcatc aagaattctc ttttcgtggt agcgtttggg
    28921 gtctggtact ggccttatat cacttactat tcattgataa gtttgttata tcgaatcgaa
    28981 aataaagatt agagctatgc ttgactggct acttttagga ttgattttgg aggaagattt
    29041 tgtctctatt atttattatt ttaaatttat ttattttgta taagatctat tctttgaggc
    29101 gggaaaaatc gaaatacttg atttatacgg cctatatcat atttggggta aatgtagtat
    29161 atggtattca atggttatta aaagaactga tttcaactat ttccccttaa tgtgtatgga
    29221 aactataaca aaacgcataa gattaaggtt tgtgtacctg ttcttatacg tttttgtcat
    29281 attgaagatt ttcggtaagt tttctacttt tgcgaagtct agtttatact caatgaaaat
    29341 taaagagtaa actagccgta ggttgctcaa agtacagctt tgaggttgca gataaaactg
    29401 acgaagtcag ctcaaaacat ggttttgagg ttgtagatga aactgacgaa gtcagctcaa
    29461 aacatggttt tgaggttgta gatgaaactg acgaagtcag taaccatacg tacggcaagg
    29521 cgacgttgac gtggtttgaa gagtattaga atgctttccc aaccaaaatc tctgcttcga
    29581 tggtaatctc tgtcagttgg ctccagtcaa tcttgctctg gtcaacgtga aagaggagag
    29641 gagtcatact gagtagggct tggagttgtt ctgctgtgat agtcttagtc agagaggcag
    29701 attgactaga taggatggta aagtgttcct ggaaatgctc cttgatatct tggttagaat
    29761 actccttgtt tgtcagctgg tcctgtactc tttgacggat ttctttgagg tgattttcag
    29821 ttgggataac ctttatcaag ataccatctt tggataaaac gcgacgaaat tctccatagt
    29881 tggcaggtga gaagatatca agcaggatat ccatgttagc gtcttttata ggaaggcgtg
    29941 ccaagtcgcc aacgaaccaa ttgactgccc agttgggttc acttttagca gcgatttgga
    30001 ctgaatcttt ggagatgtca aaggcataga aagttttttc agagtgactt tcttgtagtt
    30061 tgcgagaata gaatccttca ccacaaccga tatccaaaat tgttgtggta gtttttgagc
    30121 ttgcaagcaa gtcagataca gcatctaaga tagcttggta aaagccggct tctaggattt
    30181 gttgacggtt ttgaaaattt tccttgtcat agttagcaga ttgcttgatt tgaggtgcta
    30241 gattgacata gccaaatttc gccaagtcaa aagaatgacg gttgcagcac ttgaaattag
    30301 tctctaacag agtcagattt tcttgacaga taggacaggc aaaggcagtc gcagaagcaa
    30361 aacgctgaag tttgggcttg agatttgtat tcatagttta agtgtatcaa aagaggcaaa
    30421 tgaaagcaac tttaggaata agtagatggg agattcagta gaaataaaac taattctcca
    30481 atttatagaa tgaaattgct tttatatcta aattgctata taataatgat aaggaggaaa
    30541 taagtatgtt aaaagaagta ttaaccgttg caaaagttgc gaaaaaatct tcattatttt
    30601 tgggtggtgt cgcatttggt acccttggtt tgaaaatctt agcaagtaag gaagctaaaa
    30661 aaggttattc taaagctttg gctaaggctt acaagttgaa agacgagcta gatgcatctg
    30721 tttctgttgt gaagcaacat ggagacgatg tcttgcaaga tgccaaatat ttgtacgagc
    30781 aagagaaaaa agaagagcaa ttagatagcc ttataggtga ataatatgtc ttttaaagtg
    30841 ctacatagag gataccaaca tatccgacta tcatcttctt tttcacttac cttggatatt
    30901 caagactatc ttcgttcctt ggcgagagat gaaaagggga ttgagtctat ccagttttac
    30961 atggatcaac agcactttac tctacgcata aaagaaggct tttctgtatt agataatgca
    31021 gaagcctttt taaaaagaat tgataaaggg aaagtttctg agttgatgac tcttcccatt
    31081 cgtagagaag agagtgctta ttctattgtt tcaggtgcag cggttaagcg tgtacttttt
    31141 cgtagttttg tgccgtatcc tattcgctat atatggactt gttatcaggc tttgggttat
    31201 attagagaag cctatcaaac actagcgcgt aaggaactaa cgatggaagt cttggactgt
    31261 tcggctattt tattgtcttt gtttatgaac caatccaaga cagctagcaa tatcatgttt
    31321 atgcttgatt tggggaatca tttagatcag tggtccttga aaaaaactgc aacagattta
    31381 gaacagagtc ttcttgcaaa agagagcgat gtattcctag tacagggcga tacggttgtt
    31441 agtatcaaga gttccgatgt tcaaatagga gatgtcttga tcttatctca aggaaatgaa
    31501 attctgtttg atggacaagt agtttcaggt ttaggtatgg tcaacgaaag ttccttgaca
    31561 ggagagagtt ttccagttga aaaaagagag tttgatttgg tttgtgcaaa tacagtatta
    31621 gaaactggag agttacgcat tcgtgtaaca gataatcaga tgaacagccg tattttacag
    31681 ctgattgagt tgatgaagaa atctgaagaa aacaagaaaa cgaaacaacg ctatttcatc
    31741 aagatggcgg ataaagtcgt caaatataat ttcttggggg ctgggctgac ttacctattg
    31801 acaggttctt tttctaaggc tatttctttc ctattggtcg atttctcctg cgctttgaaa
    31861 atctctactc ctgtagctta tttgacagtt atcaaggagg ggttgaaccg tgaaatggtg
    31921 attaaggatg gagatgttct ggagaaatat ctggaagttg atactttctt gtttgataag
    31981 acaggaacaa tcacaactag ttatcctata gttgaaaagg tgttaccttt tggagactat
    32041 agtgagaaag atattctcag aatcagtgcc tgtcttgagg aacacattta tcatcctatt
    32101 gctaatgcca tcgtcaagca agctgagata gagggaattg aacatgagga aatgcatggg
    32161 aaactccaat atatcgcaag caaggggatc aaatctcata tagatggcca accagttctt
    32221 attgggaatt atgtcttgat gcaggatgag cagattcata tcagttcaga acaaaatgct
    32281 ttaattgaag agtacaagag tcactacaat ctcttattct tggcttatca aaatgaattg
    32341 attggaatgt tctgcattca tactcctttg agaaaagaag caaaaacagc cttggataaa
    32401 cttaaggcac aggggaaaaa attgattctg gcaacagggg acaccttggt taggacagag
    32461 gaattagtca aagatttgcc ctttgatcag gtctatacag acttgaaacc tgatgggaaa
    32521 tttgagttag tagagaaact gcagaaagca ggtcacacta ttttgatggt tggagatgga
    32581 ttgaatgact cagcggcttt aactctatca gatatcggtg tggtgatgaa tgagagtgca
    32641 gatatttcta agcagatgag tgatatctta ttgttagata atcgtttgga tttcttccaa
    32701 gagttggatt cgttatcatc atctttgcaa acactcatca agaaaaatat tcaagatacc
    32761 gttgtcgtaa atagtagttt gattggcttc ggcttattta attggctcag tccttcaaat
    32821 ctctctatct tacataatct aacaaccttg cgcattgtcc tgcgtagcct gtctattaaa
    32881 aatagataga tgagagttat taacagcaaa aaggagttac ctttctcgag gctaactcct
    32941 ttgtttatag ataaatgttg aatagtttag taagtcaata caaagtattt tttcttccca
    33001 cgacggataa cagtcagttc attctctaac ttatcagcgt cactcaagac atagtcaagc
    33061 tcttggatgc ggtcgccgtt tacgtagatg gctccgtttt ggacgtcttc acgggcttgg
    33121 cgttttgagt taactatacc agatgagacg agcagttcca cgatattgtt gttttcgtct
    33181 gcctgtactt ggtagtttgg cacaccacga agtccttgtt tgagctcttt gacagaaagg
    33241 tttttgatgt ttcctgcaaa gagttgctca gtgatgttaa gtgcttcttt gtaggcttct
    33301 tctccgtgaa caagtgtaac aacttcacga gccaagactt tttgagccaa gcgttcgtgt
    33361 ggcgctgctt caaattgttt acgaatatct tcaatctcat caagtgacaa gaaagtaaag
    33421 attttcaaga agcgaacagc gtcagcgtcc atcacgttca tccagaattg gtacatttcg
    33481 tatggagaag tcttttcggg attgagccag acggcatttc cttctgattt accaaatttc
    33541 ttaccagttg catctgtgat tagtggaaca gtgataacgt gaccagtctt gtccgcctta
    33601 cgacgaagca attcggtacc agctgtcata tttccccact ggtcagaacc accgatttga
    33661 agagtgacat tatggtcttg gttaaggacg aagaagtcgt acccttgcat gatttggtaa
    33721 gcgaactcag tgtaagaaat tcctgtttcg atccgttttt taacagattc cttactcatc
    33781 atgtagttga ccgtgaagta ttttccaata tcacggagga agtcaatgaa gctgatgctg
    33841 ccaaaccagt cgtagttgtt gaccatgaca gccttgtttt cgccattttc aaagtcaaga
    33901 aaacgagaaa gttgtccttg gatagacttg acccagccat ctactgtgtc ttttgtttgg
    33961 agactacgtt cagcatcttt gaaggacgga tctccgatga gacctgtagc accgccaacg
    34021 agcgcataag gtttgtgacc tgctagttgc aagcgacgac ttgtcaagat tgcgacaagg
    34081 tggcctaggt gaaggctgtc agcagttgga tcgtagccag tataataaga aacttgacct
    34141 tcttctaggg ctttacgcaa agcttcttca tcagtcgttt gaaatatcaa accacgatct
    34201 tttagctcat caaaaatgtg catgtgtctt ttctcctttt taaaattatt gtttctacct
    34261 attgtatcac aaacttgggc aatagcctag cagaataggg aagaaagtgg ctattttatt
    34321 gaaaatttcc cttttgtggt ataatagata aagtgaggaa atccatgcaa aatcaattaa
    34381 atgaattaaa acgaaaaatg ctggaatttt tccagcaaaa acaaaaaaat aaaaaatcag
    34441 ctagacctgg caagaaaggt tcaagtacca aaaaatctaa aaccttagat aagtcagcca
    34501 ttttcccagc tattttactg agtataaaag ccttatttaa tttactcttt gtactcggtt
    34561 ttctaggagg aatgttggga gttgggattg ctttggggta cggagtggcc ttatttgaca
    34621 aggttcgggt gcctcagaca gaagaattgg tgaatcaggt caaggacatc tcttctattt
    34681 cagagattac ctattcggac gggacggtga ttgcttccat agagagtgat ttgttgcgca
    34741 cttctatctc atctgagcaa atttcggaaa atctgaagaa ggctatcatt gcgacagaag
    34801 atgaacactt taaagaacat aagggtgtag tacccaaggc ggtgattcgt gcgaccttgg
    34861 ggaaatttgt aggtttgggt tcctctagtg ggggttcaac cttgacccag caactaatta
    34921 aacagcaggt tgttggggat gcgccgacct tggctcgtaa ggcggcagag attgtggatg
    34981 ctcttgcctt ggaacgcgcc atgaataaag atgagatttt aacgacctat ctcaatgtgg
    35041 ctccctttgg ccgaaataat aagggacaga atattgcagg ggctcggcaa gcagctgagg
    35101 gaattttcgg tgtagatgcc agtcagttga ctgttcctca agcagcattt ttagcaggac
    35161 ttccacagag tcccattact tactctcctt atgaaaatac tggggagttg aagagtgatg
    35221 aagacctaga aattggctta agacgggcta aggcagttct ttacagtatg tatcgtacag
    35281 gtgcattaag caaagacgag tattctcagt acaaggatta tgaccttaaa caggactttt
    35341 taccatcggg cacggttaca ggaatttcac gagactattt atactttaca actttggcag
    35401 aagctcaaga acgtatgtat gactatctag ctcagagaga caatgtctcc gctaaggagt
    35461 tgaaaaatga ggtaactcag aagttttatc gagatttggc agccaaggaa attgaaaatg
    35521 gtggttataa gattactact accatagatc agaaaattca ttctgccatg caaagtgcgg
    35581 ttgctgatta tggctatctt ttagacgatg gaacaggtcg tgtagaagta gggaatgtct
    35641 tgatggacaa ccaaacaggt gctattctag gctttgtagg tggtcgtaat tatcaagaaa
    35701 atcaaaataa tcatgccttt gataccaaac gttcgccagc ttctactacc aagcccttgc
    35761 tggcctacgg tattgctatt gaccagggct tgatgggaag tgaaacgatt ctatctaact
    35821 atccaacaaa ctttgctaat ggcaatccga ttatgtatgc taatagcaag ggaacaggaa
    35881 tgatgacctt gggagaagct ctgaactatt catggaatat ccctgcttac tggacctatc
    35941 gtatgctccg tgaaaagggt gttgatgtca agggttatat ggaaaagatg ggttacgaga
    36001 ttcctgagta cggtattgag agcttgccaa tgggtggtgg tattgaagtc acagttgccc
    36061 agcataccaa tggctatcag accttagcta ataatggagt ttatcatcag aagcatgtga
    36121 tttcaaagat tgaagcagca gatggtagag tggtgtatga gtatcaggat aaaccggttc
    36181 aagtctattc aaaagctact gcgacgatta tgcagggatt gctacgagaa gttctatcct
    36241 ctcgtgtgac aacaaccttc aagtctaacc tgacttcttt aaatcctact ctggctaatg
    36301 cagattggat tgggaagact ggtacaacca accaagacga aaatatgtgg ctcatgcttt
    36361 cgacacctag attaacccta ggtggctgga ttgggcatga tgataatcat tcattgtcac
    36421 gtagagcagg ttattctaat aactctaatt acatggctca tctggtaaat gcgattcagc
    36481 aagcttcccc aagcatttgg gggaacgagc gctttgcttt agatcctagt gtagtgaaat
    36541 cggaagtctt gaaatcaaca ggtcaaaaac cagggaaggt ttctgttgaa ggaaaagaag
    36601 tagaggtcac aggttcgact gttaccagct attgggctaa taagtcagga gcgccagcga
    36661 caagttatcg ctttgctatt ggcggaagtg atgcggatta tcagaatgct tggtctagta
    36721 ttgtggggag tctaccaact ccatccagct ccagcagttc aagtagtagt tctagcgata
    36781 gcagtaactc aagtactaca cgaccttctt cttcaagggc gagacgataa ttctctaaat
    36841 gaagtggcca atcaatggat tgccactttt ttcctttcgt gttacaataa gggtatgaat
    36901 cagtatcaga aaaagattgt taacggaaaa atttattcgc tcctatccgg cttaatatgg
    36961 ggaatctgtg gaattttagg agagtacttc tttactcatt atcaggtgtc ttcgggctgg
    37021 attacctcta tgcgtttgac actggcaggg agtcttgtac tcatttggtc tgcaatacaa
    37081 ttaaaatcgc aagtgctaga tatttggcga gacaagaaaa attacctgcc ctttttagcc
    37141 tatgctattt tggggatttt ttcagttcag tattttttct atctctgtgt agaatactca
    37201 aatgctacga cagcaactat tttacagttt attagccctg tttttatcct cttttacaat
    37261 cgcttggttt atcaaaaacg agcgtcaaaa agcgctgttt tctatgtttt ggttgccatg
    37321 ctgggtgttt gcttgatggc gacaaaggga gatctctctc agttatccat gacgccgcta
    37381 gctcttataa caggtttgct gagtgccatg ggtgttatgt ttaatgttat cttgccccaa
    37441 ccttttgcta agcgttatgg ttttgttcct acggttgggt gggggatgat tttggcaggt
    37501 ttgtttagca atgtcctctc gccggtttat cagctttcct ttactcttga tatttggagt
    37561 atcttgattt gcctcattat cgctttcttt ggaacggctt ttgctttttt catttccatg
    37621 aaggctgtgt ccttggtttc tcctttggtg gttgccgtta tcagtgccag tgaacctctc
    37681 tcttctgctc tcttgagtgt tttgttctta ggattagtag tggattggtc cctccttcta
    37741 gctatagcct tgattatttt acccatgata tttttgtcta tagaagaagc gaaagaaagt
    37801 agataaaaag tcttttctta attctaaaag tgtgctatac tagaatagtc aataaaacac
    37861 ggggagatag ttgtgaagag tgtttttagg ttgtatcggt aggggcttgc ttttaccgac
    37921 agcacgtttt atctcacatc cctaaaaaat catacctaaa aacagacaaa aaggtttcaa
    37981 atttgaggcc ttttttggta gaataggtat cattataacg aaccaggagg cacctatgac
    38041 tgctacaaaa atgaacgctc aagaaattat ccaatttatc gccaatgctg aaaagaaaac
    38101 cagtgtcaaa gtaacctttg aggggcaact cgcaactgct gtgcctagct ctgttgtcaa
    38161 actaggaaat gtcctattcg gagactggaa ggacgtggct ccgcttcttg aaggtttggt
    38221 agaaaatcaa gattatgttg tcgagcaaga tgctcgtaat tctgcagttc ctttgctaga
    38281 taagcgtgct atcaacgctc gtatcgagcc aggtgctatt atccgtgacc aggtgaaaat
    38341 tggtgacaat gctgttatca tgatgggagc tgttatcaat atcggtgctg aaatcggtgc
    38401 tggaaccatg attgacatgg gtgccatcct tggtggccgt gctatcgttg gaaaaaatag
    38461 ccacgttggt gcaggtgcag ttttggcagg tgtgattgag ccagttagtg ctgaaccagt
    38521 ccgtgtcgga gacaatgttc ttatcggggc taatgcagtg gttatcgaag gagtccaaat
    38581 cggtagtggt tcagttgtcg cagcaggagc tattgttacc caagatgtcc cagaaaacgt
    38641 ggtagtagca ggtgttccag ctcgtattat caaagaaatt gatgcccaaa ctcaacaaaa
    38701 aacagcgtta gaggatgcgc ttcgtacctt gtaattgtaa aagtaaaaaa gaggcggaac
    38761 cctttttcca gcctctttct gctatatcgg aggacagata gatgttagat ttgattcaga
    38821 ctagacgaga tttacaccag attccagaga ttggcttgga ggagttcaag actcaggctt
    38881 atttgctgga tgtgattgag aaattgacta cgggcaagga ttttgttcaa attcgtactt
    38941 ggcggacagg gattttggtc tacctgcagg gaagtcagcc ggagcgaacc attggttggc
    39001 ggacagatat tgatggcctg cctatcgtcg aacaaacagg tctacctttt gcttctcaac
    39061 accaaggtcg catgcatgcc tgtggccatg attttcatat gaccattgcc ttaggctgtc
    39121 ttgagcgcgc ccttgaggag caacctaaaa ataatctgct ctttctattt cagcctgctg
    39181 aagaaaatga agctggtggt atgctcatgt atgaggctgg tgcttttgga gattggttgc
    39241 cagatcaatt ttatggcctc catgtccgtc cagatttgaa agtcggccag attgcgacta
    39301 atactcatac actctttgca ggaacttgcg aggtgaagat ccgtttcaaa ggtaaaggtg
    39361 gccacgcggc ttttcctcat gaagccaatg acgccttggt ggcggctagt tactttgtga
    39421 cccaagtgca gtcagttgtt agccgcaatg taaacccaat cgagggagca gtggtgactt
    39481 tcggcgtttt tcaagctgga accaccaaca atgtcatcac agacacagct tttttacatg
    39541 gaactattcg tgccttgaca caggacatga gtctcttggt gcaaaagagg gtaaaaacag
    39601 ttgcagaagg gattgcagct gcctttgata tggaagtcga agtggaactc aaacaaggtg
    39661 gatacctacc tgttgagaac aatccagcct tggcgcgtga actgatggac ttctttgacg
    39721 aaaaagacgg aatcgagttg attgatatcg aacctgctat gacaggcgag gactttggtt
    39781 atctcctttc aaaggttgat ggcgtgatgt tttggctagg tatcgatagt ccctacgctc
    39841 ttcatcaccc tcaaatgagt cctaaggaag aagtcttagc tattggggtg gctgcggtgt
    39901 ctagtttcct gaaaaagaag gcagcagaat agagggcttg tctatgaaat cggaattacg
    39961 caagcaagtc ttgcatgaaa tgaaggcttt atctcaagaa caaaaacagg ctatagacca
    40021 agctttaacc gagcgaattt tacaacaccc cttttatcaa gaagccaagg tcatcgcaac
    40081 ctacctctct ttttctcatg agtttcaaac gcgggaactg attgagcagg cgctgaagga
    40141 cggcaagaag gttttaatac ccaaaactta tcccaagggg cgcatggact ttgtagtcta
    40201 tgatccgcag cagttggtaa aaactgcctt tgccttactg gagccacagg gagatttgga
    40261 agtggtggat gtatctcaga ttgatttgat tcatgttcct ggcctggctt ttacgacgga
    40321 tggatatcgg attggatatg gtggaggtta ttatgaccgc tatctggaac atttttctgg
    40381 tcatactttg agtacggttc atccttgtca aattcaggac tttatacctg aaaaccatga
    40441 tattcctgtt caggaggtat taattgatga aggaaatctt tgatagacgt taccctgtga
    40501 cgagtttctt cctcttagtg acggccttgg tatttttact aatgttggtc actgcaggcg
    40561 gaaactttga cagggcagat acattatttc gatttggagc catgtatggg ccagctattc
    40621 gcctctttcc cgagcaggtt tggcgtctct tgtctgccat ttttgttcat attgggtggg
    40681 aacatttcat tgttaatatg ctttcacttt attatcttgg aaggcaggta gaggagattt
    40741 tcggctctaa gcagttcttt tttctctatc tcttatcagg aatgatgggc aatctctttg
    40801 tttttgtatt tagtcctaaa tccttagcag caggcgcctc tacctctctt tatgggctat
    40861 ttgccgcgat tattgttctt cgctatgcaa ctcgcaatcc ttatatccaa cagctagggc
    40921 aatcctatct gacacttttt gtggttaaca ttattggaag tgttctgatt ccaggaatca
    40981 gcctagcagg ccatatcggt ggtgcagttg gtggcgcatt tctagcagtt atctttccag
    41041 ttagaggaga aaaacggatg tataatacca gccagagatt aggagcggta gtcttgttcg
    41101 taggactcgc cattttgctt ttctacaagg gaatgggaat gtgacgaagt tgaaagaaaa
    41161 tttgtgtaat gaaaaaagat aaggcatttt ttgaacctta tctttttatt ttattttatt
    41221 ccttctcagt caattctttt ccaagttgga tgaggtaatt cttcaaatca tctttgactt
    41281 gtgggtgttt gagggcgtag tcgatggatg ttttcatgaa gccaaacttg tctccgacat
    41341 cgtaacgagc cccattgaac tcacgagcaa atacacgttg tgttttattg agggtgtcga
    41401 ttgcatctgt cagctgaatt tcatttcctg cacctggagc ttggttttcg aggatttgga
    41461 aaatttcagg cgtgaggagg tagcgtccga taatagcaag gtcgctagga gcgtcctctg
    41521 gagctggttt ttcaacaaag gtttcaacac tgtaaagacc atcttttcct tcgccttgcg
    41581 gagcaataac cccgtaagca gatacttcgt catgagggac tggcatgaca gcgatagtag
    41641 acgcgtgggt acgctcgtag tcatccatga gttgtttggt aagtggaaca gccttttcgt
    41701 ctgtgatatc catcaagtca tcaccaagca taacgacaaa aggttcattt ccgacgaaag
    41761 ccttggcttg caaaacagca tctccgagac cgcgtggatg agtttggcgg ataaaatgca
    41821 gacgcatgtc agttgtttta tcaactagct tcaaaagatc tgttttccct ttttctttga
    41881 ggttatattc caattcgaag tttgaatcaa agtggtcctc aatagaacgt tttgatttac
    41941 cagtgacaac tagaatatct tcaatacctg atttgagagc ctcttccacg ataaactgga
    42001 tagttggttt gtctacgatt ggcaacattt ctttggcaag ggccttggtt gctggtaaaa
    42061 atcgagttcc tagtccagca gcagggatga ctgcctttct aacttttgat gtcataaaaa
    42121 tcctttctat agagggttaa gaccactcat tttctgcttt aaattcattg ttcatgatgt
    42181 cataaatggc atctttgata ttggttccgt gataaataac ttggtaaata gcctgtgtaa
    42241 tgggcatata gactccaagt tcttgggcta gttcataggc tgctcgagtc gttgaaattc
    42301 cttcgattac catgcccata ttagcttcta tatcagctag ggattctcct cgtccgagag
    42361 catctccagc tctccagtta cgagagtgga tggaagttcc cgttacgatc aaatctccca
    42421 caccagataa gccgctatag gtcaatggac tggccccgag tgctacccct aggcgggtga
    42481 tttctgctaa acctcgagcg atgatggctg ccttagcatt atcaccaaat ccaagaccat
    42541 gtaaagctcc agcaccgaca gcaataatat ttttaagagc accagcagtt tcaaccccga
    42601 taacatccgt attggtataa agtcggaagt agtgattact aaatagcttc tgaacgtatt
    42661 gagctgtttg taaatcttta gaagcagcag ttattaaagt taggtcacgc acaatggtct
    42721 cttctgcatg actaggccct gaaacaacga cgatatcact acggagatgt tcaggaattt
    42781 cttcttcaag aatggttgat aatcgtttat ggctatcagg ttctaatccc tttgatgcgt
    42841 gcatgatgat aaccttatgg tccaaggttt gtgcaacttg ctgggcaaca agtcgtgtca
    42901 cttttgttgg gacaacaaac aaaatcgcat ccacatcttt caatgtttct gctaagtcgg
    42961 tgtaggcaat gatattttcg tctagaacga catctttaaa gtagtgctta ttagtatggt
    43021 gtgtattaat ttcattgatt tgctcgggaa gatttcccca aatacgtacc tcgtgtccat
    43081 tgtcatttaa gacttgtgaa agggcggttc cccaagaacc aggccccaag acggcgacgg
    43141 tttgtttttc catgatttcc tccttgatag agttctttct cttattctat catattctag
    43201 gggattttgc acttgcatta ctggggtatg gtggaaaaat acacaaaaac cgagatgaag
    43261 ggataaactc ttagtcttta gttaaagtga gaagaaatct gatagatagt ttgattcagt
    43321 atatgctata aatagaggta aacaactcag gaggttcttg taggttgcga gagtttggcg
    43381 aaaaaattaa aagattacgt ttggctaaaa aaatcagtcg ttcagaattt tgtggtgatg
    43441 agtctgaatt aagtatccgt caattaatta gaattgaaaa tggagaatcc agaccaacac
    43501 taacaaagtt aaaatatatc gctgaacgtt tgggggttga agattacaag ttgatgccaa
    43561 gttatataga gttggataag gaatacctag aattgaagta tttcttgatg aggactccta
    43621 catacgaaga tgaaactatc gcccaaaaga aagagagtgt tttgataaga tttttgaaga
    43681 gtattatgat aggctacctg aggaagaaag atttatcatc ccaaattatt catatctggc
    43741 actaacgaac tacacagttc aaaaattacc agaaaagcta gttgaaatac tgtccttctg
    43801 gtgattttgc ttaatttctg atgttcgaga cataattgag gagatttgtc ttgatttttt
    43861 cctaaaaaag ggcagactcc tcccttggtt tgatgctcga tttttaaaat aaggtgactt
    43921 attctgttag gcatgttttc ccctgccctc tagctctata tggaacaggg agtatcagat
    43981 ttatctggca gattgtatca aataaggctt gaaactgttt tgaataggcg tatagacttg
    44041 agaatttgag aatatgtcgt ctagcagtag agacatattt tccggcaata tgaaggaaga
    44101 gacgtcgaaa acgcttgata gtcaaggcct ttacttcatc accagctagc tgctttaaaa
    44161 agaggtagag attataagcc agacagccca tcatcatacg tacttcattc ttaatcatgg
    44221 tcgaactatc tgtcttatcc ccaaagaatc ctgctttcct ttctttgata aagttttcag
    44281 cattccctcg ttcacgatag aattgaaaca gctcctcact atctacactg cttaaattgg
    44341 tcaaatgaac ttttttacaa ccataaaaaa gagcacttaa tcgtactctt ctcttttaag
    44401 gattagttga attaattcaa atccactagt tctcctgttt ctaggtagac taggcgttca
    44461 caaatgttag caatgtaatc agcgaagcgt tccagatgcc ctatgatata aaggtattga
    44521 gttccattgg gaattgaggt ttcttggtct ttcataagtc caatgatttc ctttgataag
    44581 gcataataat attggtcaat ctgttcatct ttttgagcaa tactaatagc ttttgaggct
    44641 tggtgcaaag gaaaggcaac caataaatcg gctagcatgc tgagggataa tttacccatt
    44701 tggtgtaact gttcttcgtc aggggctagt tgattttctt ttagttgcaa aacagctttg
    44761 gcaatgcctg ccatatggtc tcccatacgt tcaaggtctg aacaagaaga catgatgcta
    44821 attacaaatc gaaggtcaga cacttgtggc tgctgcaagg ccaacaaacg ggcacaggtc
    44881 aattcgatag cgctttgacc ttggttgata gcatgatcct tattgataat tagctctgcc
    44941 atctccttgt ctttggaggc taaggccagt aaggcttttg aagctgtttc aaggacaagt
    45001 tgccctagtc ctaaaaagga ttgttctaat tcatgcaatt ctaagtcaaa ttgatttctc
    45061 ataggttttt ccttccttat ccgaaccgtc ctgaaatata gtcttctgtg cgctgatctt
    45121 ttggattggt aaacacgtca acggtatctc caaattcgca aatttctcct gttaagaaaa
    45181 aagcagtttt atctgaaata cgtgaagctt gttgcatgtt atgggtaaca atgataatcg
    45241 tataatcctt ttttagttgc tgaatgaggt cttcaatttt taaagtggag atagggtcta
    45301 aggctgaagt cggctcatcc attaacagaa catcaggttc tactgctaaa gctcgcgcaa
    45361 tgcaaaggcg ttgctgctga ccgccagata aggacatggc actcttttta agatcatctt
    45421 tgacttcttc ccaaatggct gcccctttta aagatttctc cactaaggca tctaattgtt
    45481 ttttgtctcg aataccatgt gtccttggac cataagccac gttatcatag atagacatgg
    45541 caaagggatt aggctgttga aaaaccatcc ctacacgctt gcgtagctga ttaaggttga
    45601 atttgctact ataaatatct tgctcatcta agaggacttg gccttcaata tggcaagaag
    45661 gaaccaaatc gttcatccga ttaagggttt ttagaaaagt tgatttgcca caaccagatg
    45721 ggcctatcaa ggcagtaatc tgtctttctg gtaattgaat cgaaatattt tttaaggctt
    45781 gaaaatcccc gtaaaataaa tctaggtgtc taactgaaaa tgttcccata ctaggaagct
    45841 cctttcacaa gtttccgaga taataagctt gatagagtat ttatcattaa aacagtaata
    45901 atcaaaatca cgccggtagc ataggcttca ttgacatgta gcccctcact tgacagcata
    45961 tacatatgta gggctagaga acggcctgaa gacatgagac tacttggcgt attggtagag
    46021 gtacctaatg tatacatgag ggcagctgtt tcaccaacga tacggccaat agctagtatc
    46081 actccagcta aaatacctgg catggcaact ggtagaacaa ttctaaaaac agtccgtaac
    46141 ttacctgccc caagtccata acttgcttga cgcatgctat cactaacaga taaaagggct
    46201 tcttctgttg agcgaataat gactggcaac accatgataa ctgaggttaa gattcctgat
    46261 aacagagagt attgaaaacc taagaagact acaaagaaga gcatgccaaa cagaccaaaa
    46321 acaatggaag gaatcccaga caaggtatct gaggccaatc gcatgatttt aacacaaagg
    46381 gaatcttttt ttgtatattc cacaagataa aaaccagcaa aaatccctat gggcaaggct
    46441 aaaagaagag caccaaaaac cagaataacg gtggaaataa tcgctggcat aagggaaatg
    46501 ttctcagaag tataagtcca agaaaagagg gatagactta gatgaggtaa gcctttgatg
    46561 aggataaaac caatgattaa aaagagagag ccaaaggtta aagctgaaaa acaataaacg
    46621 agaagtttta gcaggtattt actcataaga tgattttcct ttcaagtagg caaagtaggc
    46681 attaatcaag agaataagga aaaagagaac tgctgaggtt gcaataaggg cttccctatg
    46741 ctgacctgat gcgtaagcca tttccagaac aatattggtt gttaaggttc tggttcctga
    46801 aaagagtcca cttggaataa tcggctggtt gcctgccacc aaaataactg ccatggtttc
    46861 acctactgcg cgaccgattc ctaaaataac tgctgataaa ataccagatc tcgcagctgg
    46921 caagatgaca ctaaaaatac tccgttcatg actagctcct agagccaagc taccagaata
    46981 atacgttttg ggaactgttc ggatagcaga ttctgacaaa ctgataatgg ttggcaaaat
    47041 cattattcct aatagtaacg aagcggttag gacactcatg ccatttccta aaaaggttct
    47101 aatccaaggc accaataatt gtaggccgaa aaaaccataa acaatagatg gaatggccgc
    47161 catcaagttg atagctgatt ttaagaagcc atagacgggc tttggacaat aataaaccat
    47221 aaacaccgat gtcaagatgc ctgttggcac cccaatcaca atcgctccta aggtaattaa
    47281 taaggaacca acgatcattg gtaaaatacc atagcttgcc ggaatgttcg ttggcgacca
    47341 atcactgcct aataaaaaac gggcaaagcc gtagttagcc atgaaaggta agccattact
    47401 aaaaataaag aaacagatta gcaaaatagc tacaacagct actgttgcac tcatgaaaaa
    47461 aattgcccta aaaactgctt ctttgaaggc ttgttttatc acatcttgtc ctttctagtg
    47521 aagaaagtaa gggagatacg acacctccct acttgccttc tttatcttat tgtacgatga
    47581 aacgtctgca tctctttaga gatttatgga gcaaacattt tatttaatct tgtcccaggt
    47641 ggttaatttg ccactaaaaa cgtctgcaag ttcagccata ctgacttggc ttgccttatt
    47701 gtcattattg accacaacag caataccgtc taaagcaata gcatcatggg tgagactctt
    47761 accttcttca ggagttaatt ccctagaaac cataccaata tcagcggttt tctccttaac
    47821 agcggtaata cctgctgaag acccattaga ggtaatatca atcgtaactt ctggattttc
    47881 ttttttataa gcttctgcta atttttccat taaagaagat actgaagtgg aacctacaac
    47941 agacaacttg cctgataagt gttggcttgt atattctgtg gtttcggttt tagcttcaat
    48001 aaatttatta tctgtgacca cttgttgacc ttgtttggag tggataaagc tgataaaatc
    48061 ttgacctagc ttggaaagat tagaagacca aacaatgttg aagggacgtt gaagagggta
    48121 ttcaccatct aaaactgtgt ctcgactagc cttgacacca tcaatctcta aagccttgac
    48181 agattttgtt aaagatccca aggagatgta gccgatagca ttagcattcc cttgaactgc
    48241 tgagagaaca ccttctgtac tattttgaat cacagctgtt ttggcagtgt tgtcaatttt
    48301 tttatcaccg tcttttttga gaatccctgt gatttctgtg aaggcacccc gtgttccaga
    48361 gccattttct cgtgaaatca cctcaatcgt tcctgaagct gactgtttgg aagcagctga
    48421 ctgattgcca caggcaacaa gcccaaatcc tgataagcca atggctgcaa gagtaagcat
    48481 ttttttgaat ttcataataa tcacctttat ctctatgtat ttttcttgtg taggcttact
    48541 acatttatag tctaacaagt ctttgtaaag gtttatccct gattcatgta aagattgtgt
    48601 aaagaatcaa aaaaagccac ttttgaaaaa tggctgctcc taaaaatagc tttaaaaatt
    48661 attagtcctg tgcgaaagat tggttaggaa gaaaaatcgt gaagcaactg cctctgccaa
    48721 gctgactcgt caccgtgact tggccaccta ataattgact gagttctttg acaatggcaa
    48781 ggccaagacc agtgccacca gtttgtctgc ttcgaccttt attaactcgg taaaaacgtt
    48841 caaaaatacg atcctgctct aattgactaa taccaatccc tgtatctgat acagaaatct
    48901 taatgccttc gttcaccttt tgggtcttga cctcaatttt tcccccttgt tcagtgtaac
    48961 ggatggcatt ggataaaaga ttgagtaaga tttgggaaag taattgacta tctgatacga
    49021 gggtgacatc atctggcacc tgcaccttta gctgtaaatc cttcttcttg agctgaggtt
    49081 gcaagctttg agtcaaatcc tgtacaaatt ctgccaaaga aagggtcgtc cattgtatag
    49141 gcatttgttg agccttagat aaggtaagaa gatgctcaac aatatgctca agacgcaaac
    49201 tttctttgta aataatgtct agaaagtcat ccttgagcgc ttcttcttca gctgacatcc
    49261 ccttaatggt ttcagcaaag cccttaatcg aagtaactgg tgtcctcaat tcatgggagg
    49321 catttgagac aaaggctaaa tttaactttt cataagttct aatcgttgtt aaatcatata
    49381 gcaagacgag cacagcttcc acagattggg tggggctaaa aacgggaact gctgtcactt
    49441 ctaaaatcaa gtcaccctca tgaaacccac ttacttcttg ttttaacctt gttttttgat
    49501 caaaggcttg gtgaactaaa ttccgaatat ccatccgttt gaggtcatca agtgaactta
    49561 tgtcgccgtc cacatcggga aaataatgag gcagagagcg actggataat aacatctgac
    49621 cttgagcgga aactaaaaac gtccccatgg ttaggtgcga cagaagaacc tccattgttt
    49681 cggctagatc cttgtattgc tgatcctgtt gggagacttt ggtttttagg ccagacacat
    49741 actgagccaa agactttaag tcttcttgcc ctttttctaa aaagtattca ctactggtca
    49801 agagaggttg gtgcaaggtc tcaaaagcaa cttcccattt ccaaaggcaa aagagccagt
    49861 agccacctag tcccaaagaa agggctagaa gaaagagacc gatgccttta ctgatccaag
    49921 ttaatgccat ccctgcaatc agaatgaggc taacacttag attgactagc caaaattgaa
    49981 ggtagcgttt catctataac tccttgaact tataaccata accccgaatg gttcgaataa
    50041 attgaggggc tttaggattg tcttcaattt tttccctcaa cttaccaata tgaacgtcca
    50101 ccaaacgtgt ttcctgccca aagtcatacc cccagatacg ttccaaaaga cgctctctag
    50161 tcagtgtcat gttgggatgt ttcataagat agagcaagag ttcaaattct tttggggtca
    50221 aactcagtaa cttattcgcc ttgtagactt catgacgctc agggtatact ttcaaggtcc
    50281 caaatagcca agaatcgtca gcgatattat ctgaatcatc tccttcttgt tctcctttag
    50341 ttcgcctgag gacagccttg acacgcgcca gcaattctct agggctaaaa ggcttggtca
    50401 ggtagtcatc agcccctaat tccaaggcca aaaccttatc aaattcatca cttttcgcag
    50461 aaaccatcat aattggagtt ttgacgcctt tggctctcag ccgcttacaa acttccatgc
    50521 catctaattg tggtaacatg atatcaagca agataaaatc aaagggttct gtttctgcca
    50581 aagctaaggc cttccgtcca tttgtcacca attgagtaga aaagccttcc ttacttaaat
    50641 ggtagtcaag caatttcaga atgtgttctt catcatccac taataagact tgttttgtca
    50701 tctattatct cctattggta acattataac acaattatca gaaatcctaa cattgctaaa
    50761 tcagattaaa tttgcctatc aagactagta tctggtcaaa cgctcaatca tctccttgtg
    50821 ctctggatag gtcgccagta gatctaccct ttcaaataat tcaaaatcct caaattcaaa
    50881 accaggagca acaagacaag aaaccagagc atcatcctta tcaactgttg atccccaaat
    50941 agtgccctta ggaacacagt agtgaagttg ttgccctttg gatatgtcca ggcctaaagt
    51001 gactgcttcg tagtgaccat ctgctgtaat catgtgaaca gtaagtgggg atcctgcatg
    51061 aaaataccag atttcatctg ctgtcaatcg gtgaaaatgt gaaggattcg tttcttctaa
    51121 taagaaataa atactggtat aaagcgccct tcccttacca gcaaggttta tagtgtctga
    51181 agcttttttt gtttgtctaa aatagccacc ttcaatatgg ggagctaact ctagagttct
    51241 tatcaagtct tctttatccg tcggagccaa tgggttgaag taactcttgt tcaaagtggt
    51301 tttacgattt caagaactcc tctcagttct gaggacacgg taatgattga tgcgacggaa
    51361 gtacaaatca atcgccctaa aaaaagaatt agcgaattat tctggtaaaa aaaatgccac
    51421 gctatgaagg ctcaagcgat tgtcacaagt caagggagaa ttgtttcttt ggatatcgct
    51481 gtgaactatt gtcatgatat gaagttgttc aaaatgagtc gcagaaatat cggacaagct
    51541 ggtaaaatct tggctgacag tggttatcaa gggctcatga agatatatcc tcaagcacaa
    51601 actccacgta aatccagcaa acttaagcca ctaacagttg aagataaagc ctataaccat
    51661 gcgctatcca aggagagaag caaggttgag aacatctttg ccaaagtaaa aacgtttaaa
    51721 atgatttcaa caacctatcg aaatcatcgt aaacacttcg gattacgaat gaatttgatt
    51781 gctggcatta tcaatcatga actaggattc tagttttgca ggaagtctat tatttggtta
    51841 ggtgaattag tgaagcgttt aggcaagtgt ctctggttac gacgtcatgg actctaaatc
    51901 gattatattt aggggtcatg actagtgaag cagttagcta gttcgcatat aagcggctag
    51961 cgtctaacaa ttaggaactt tagttccaat aactttaaga ttacgacgtt ttaggacata
    52021 aatcgatcat atttatgtcc taaaactagt gaagcgccta gccaaagtcc gaataggatt
    52081 tggcgttagt tacttagatt gctttgcaat caagtaactt tggcgattta catcttctct
    52141 ggcgcttcta ctccaagcaa gcgaagggct tctttgagaa cgactgcggt tgcgtagctg
    52201 agggctagac ggctgtcgcg ttctgggctt tcatccaaga tacgtgtatg tgcatagtat
    52261 ttgttaaagg attgagccag gctaattgca aatttagcaa tgatagaagg ttcaaagtta
    52321 tctgccgcac ggttgataat acgtgggaag tcttgaatga gtttaatgat ttcccagctt
    52381 tcagtatcat tcaagctata gttgccagct gtttctggtt tgaaatcggc tttgcgtaag
    52441 atagattgga tacgagcgta ggcatattga acgtaaggtc cagtttcacc ctcgaaggat
    52501 accatagcct ctaggtcgaa gtcgtatcca tttgtacggt cggttttgag gtcatagaat
    52561 ttaatggctc caatcccaac agcatgtgct acttggtctt tgttttctag ttcaggattt
    52621 ttagcctcga tttggacctt ggcacggcta acagcctctg caacagtagg ctctagcaag
    52681 atgacattcc ctttacgagt agagagtttc ttcccttctt ttgtaaccaa accaaaagga
    52741 acgtgagtaa tgtcgtcact ccagtcgtag cccatctctt gcaagacagc tttgagctgt
    52801 ttaaagtggg cagattgttc ttgaccaacg acatagatag atttagcaaa ttggtattcg
    52861 tttttacggt agagggctgc agccaagtca cgtgtgatat agagagttgc accatcagac
    52921 ttcttgatga gggctggatg ttcaattcca tatttctcaa gattcacaac ttgggcacct
    52981 tctgattcaa gaagtagtcc tttttcagaa agaatgtcta caactgcatc catcttatca
    53041 ttgtagaagg cttctccgtt atagctgtca aattcaacct tcaattcatt gtaaaggcgg
    53101 ttaaattcca ctaaactttc atcgcggaac cattgccaaa gagcgagagc ttcctcatct
    53161 ccattttcaa gtttacggaa ccattcgcgc gcttcttcat ccaagctagg gtcattttca
    53221 gcttcagcgt tgatgcggac atagagttta aggagttcat cgattggatg agcttttaca
    53281 gcttcttcgt cgccccattt tttgtaggca acaatcaaca tcccaaattg tttaccccag
    53341 tctcccaaat ggttgacctt gaccgtttga taaccgattt tttggaaaat atgtgacaag
    53401 ctatctccga taacagttga acgcaggtgg ccaatagaaa atggtttagc gatattcgga
    53461 ctagacatgt cgataacaac attttcttgt ttaccaatat tttggtcagc atagtgttct
    53521 ttttcagtgg taacagcttg caatacttga gcagaaatgg cagatttatc aaggaaaaag
    53581 ttaacgtaag gtcctgttgc gacaactttt tcaaaggctt ggctgttcat tttttcagcc
    53641 agttcagccg caatcatttg tggtgcttta cgttcgactt tggcaagaga aaaagcaggg
    53701 aaagcgatgt cacccatttc tgagttttta ggggtttcca gtaactttaa aatagcctct
    53761 tggtccaggc tatcaatgat gctagccaat tcgctagcaa tcaattcttt tgtattcatt
    53821 aagagctcct ttttggactt ttctactatt ttatcacaat tttaaagaaa gaagaaaaaa
    53881 tttttgaaat ctcctgtttt tttggtataa tatggttata aatatagtta taaatatgca
    53941 cgcaagagga ttttatgaga aaaagagatc gtcatcagtt aataaaaaaa atgattactg
    54001 aggagaaatt aagtacacaa aaagaaattc aagatcggtt ggaggcgcac aatgtttgtg
    54061 tgacgcagac aaccttgtct cgtgatttgc gcgaaatcgg cttgaccaag gtcaagaaaa
    54121 atgatatggt gtattatgta ctagtaaatg agacagaaaa gattgatttg gtggaatttt
    54181 tgtctcatca tttagaaggt gttgcaagag cagagtttac cttggtgctt cataccaaat
    54241 tgggagaagc ctctgttttg gcaaatattg tagatgtaaa caaggataaa tggattttag
    54301 gaacagttgc tggtgccaat accttattgg ttatttgtcg agatcagcac gttgccaaac
    54361 tcatggaaga tcgtttgcta gatttgatga aagataagta aggtcttggg agttactctc
    54421 aagacttatt tttgaaaagg agagacagaa aatggcgata gaaaagctat cacccggcat
    54481 gcaacagtat gtggatatta aaaagcaata tccagatgct tttttgctct ttcggatggg
    54541 tgatttttat gaattatttt atgaggatgc ggtcaatgct gcgcagattc tggaaatttc
    54601 cttaacgagt cgcaacaaga atgccgacaa tccgatccct atggcgggtg ttccctatca
    54661 ttctgcccaa cagtatatcg atgtcttgat tgagcagggt tataaggtgg ctatcgcaga
    54721 gcagatggaa gatcctaaac aagcagttgg ggttgttaaa cgagaggttg ttcaggtcat
    54781 tacgccaggg acagtggtcg atagcagtaa gccggacagt cagaataatt ttttggtttc
    54841 catagaccgc gaaggcaatc aatttggcct agcttatatg gatttggtga cgggtgactt
    54901 ttatgtgaca ggtcttttgg atttcacgct ggtttgtggg gaaatccgta acctcaaggc
    54961 tcgagaagtg gtgttgggtt atgacttgtc tgaggaagaa gaacaaatcc tcagccgcca
    55021 gatgaatctg gtactctctt atgaaaaaga aagctttgaa gaccttcatt tattggattt
    55081 gcgattggca acggtggagc aaacggcatc tagtaagctg ctccagtatg ttcatcggac
    55141 tcagatgagg gaattgaacc acctcaaacc tgttatccgc tacgaaatta aggatttctt
    55201 gcagatggat tatgcgacca aggctagtct ggatttggtt gagaatgctc gctcaggtaa
    55261 gaaacaaggc agtcttttct ggcttttgga tgaaaccaaa acggctatgg ggatgcgtct
    55321 cttgcgttct tggattcatc gccccttgat tgataaggaa cgaatcgtcc aacgtcaaga
    55381 agtagtgcag gtctttctcg accatttctt tgagcgtagt gacttgacag acagtctcaa
    55441 gggtgtttat gacattgagc gcttggctag tcgtgtttct tttggcaaaa ccaatccaaa
    55501 ggatctcttg cagttggcga ctaccttgtc tagtgtgcca cggattcgtg cgattttaga
    55561 agggatggag caacctactc tagcctatct catcgcacaa ctggatgcaa tccctgagtt
    55621 ggagagtttg attagcgcag cgattgctcc tgaagctcct catgtgatta cagatggggg
    55681 aattatccgg actggatttg atgagacttt agacaagtat cgttgcgttc tcagagaagg
    55741 gactagctgg attgctgaga ttgaggctaa ggagcgagaa aactctggta tcagcacgct
    55801 caagattgac tacaataaaa aggatggcta ctattttcat gtgaccaatt cgcaactagg
    55861 aaatgtgcca gcccactttt tccgcaaggc gacgctgaaa aactcagaac gctttggaac
    55921 cgaagaatta gcccgtatcg agggagatat gcttgaggcg cgtgagaagt cagccaacct
    55981 cgaatacgaa atatttatgc gcattcgtga agaggtcggc aagtacatcc agcgtttaca
    56041 agctctagcc caaggaattg cgacggttga tgtcttacag agtctggcgg ttgtggctga
    56101 aacccagcat ttgattcgac ctgagtttgg tgacgattca caaattgata tccggaaagg
    56161 gcgccatgct gtcgttgaaa aggttatggg ggctcagacc tatattccaa atacgattca
    56221 gatggcagaa gataccagta ttcaactgat tacagggcca aacatgagtg ggaagtctac
    56281 ctatatgcgt cagttagcca tgacggcggt tatggcccag ctgggttcct atgttcctgc
    56341 tgaaagcgcc catttaccga tttttgatgc gatttttacc cgtatcggag cagcagatga
    56401 cttggtttcg ggtcagtcga cctttatggt ggagatgatg gaggccaata atgccatttc
    56461 gcatgcgacc aagaactctc tcattctctt tgatgaattg ggacgtggaa ctgcaactta
    56521 tgacgggatg gctcttgctc agtccatcat cgaatatatc catgagcaca tcggagctaa
    56581 gaccctcttt gcgacccact accatgagtt gactagtctg gagtctagtt tacaacactt
    56641 ggtcaatgtc cacgtggcaa ctctggagca ggatgggcag gttaccttcc ttcacaagat
    56701 tgaaccggga ccagctgata aatcctacgg tatccatgtt gccaagattg ctggcttgcc
    56761 agcagacctt ttagcaaggg cggataagat tttgactcag ctagagaatc aaggaacaga
    56821 gagtcctcct cccatgagac aaactagtgc tgtcactgaa catatttcac tctttgatag
    56881 ggcagaagag catcctatcc tagcagaatt agctaaactg gatgtgtata atatgacacc
    56941 tatgcaggtt atgaatgtct tagtagagtt aaaacagaaa ctataaaacc aagactcact
    57001 agttaatcta gctgtatcaa ggagacttct ttgacaattc tccacttttt tgctagaata
    57061 acatcacaca aacagaatga aaaggagctg acgcattgtc gctccctttt gtctattttt
    57121 taaggagaaa gtatgctgat tcagaaaata aaaacctaca agtggcaggc cctggcttcg
    57181 ctcctgatga caggcttgat ggttgctagt tcacttctgc aaccgcgtta tctgcaggaa
    57241 gtcttaggcg ccctccttac tgggaaatat gaagctattt atagtatcgg ggcttggttg
    57301 attggtgtgg ccgtagtcgg tctagttgct ggtggactca atgttgtcct cgcagcctat
    57361 attgcccaag gagtttcatc cgaccttcgg gaggatgcct tccgtaaaat tcaaaccttt
    57421 tcttatgctg atattgaaca atttaatgcg ggaaatctag tcgttcgaat gacaaatgat
    57481 atcaaccaga ttcagaacgt tgtcatgatg accttccaaa ttcttttcag acttcccctc
    57541 ttgttcatcg gttcgtttat cctagcggtt caaaccttac cttctctgtg gtgggtgatt
    57601 gttctcatgg tagtcttgat ttttggtttg actgctgtca tgatgggaat aatggggcct
    57661 cgttttgcca agtttcaaac ccttcttgag cgcatcaatg ccattgccaa ggaaaattta
    57721 cgtggcgttc gtgtggtcaa gtcctttgtc caagaaaaag agcaatttgc taagtttaca
    57781 gaggtctcag acgagcttct tggtcaaaac ctttacattg gttatgcctt ttcagtagtg
    57841 gaacccttta tgatgttggt tggttacggg gcggtcttcc tctctatttg gctggtcgcg
    57901 ggaatggttc agtcggatcc gtctgttgtt ggttccatcg cttcttttgt taattaccta
    57961 agccagatta tctttaccat tgttatggtt ggatttttgg gaaattctgt cagccgtgcc
    58021 atgatttcca tgcgtcgtat tcgagaaatt cttgacgcag agccagctat gaccttcaag
    58081 gatatcccag atgaagagtt ggttggaagt cttagctttg aaaatgtgac ctttacctat
    58141 ccaatggaca aggaaccgat gctgaaagtt gtgagcttta ctattgaacc tggtcaaatg
    58201 gttggtgtag ttggagcgac tggtgcagga aagtcaacct tggctcaatt gattccacgt
    58261 ctctttgatc cacaggacgg ggccattaaa atcggtggca aggatattcg agaagtgagt
    58321 gaaggaaccc tgcgtaaaac agtttccatc gttctccaac gtgccattct ttttagtgga
    58381 acgattgcag ataacttgag acaggggaag gggaatgcta ctctatttga aatggagcgc
    58441 gcagccaata ttgcccaggc tagtgaattc attcatcgta tggagaaaac ctttgaaagt
    58501 ccagttgaag aacggggaac caatttctct ggtggacaaa aacaaaggat gtcgattgcg
    58561 cgtgggattg tcagcaatcc acgtattctg atttttgatg attcgacctc agccttggat
    58621 gccaaatcag agcgcttggt gcaagaagct ttgaataagg acttgaaggg gacgacaacc
    58681 attattattg ctcaaaaaat tagctcggtt gtccatgcag acaagatctt ggttctaaat
    58741 caaggacgat tgattggtca aggtacgcat gcagacttgg ttgccaacaa tgccgtttac
    58801 cgtgaaatct atgaaacaca gaaatgaaag acaaactata agaaaagtca atagttttat
    58861 ctaaactatt tcttatttca atttgatgat ttggcgatga ttttagagca cggcaaaagg
    58921 cccttgaaaa agtccatttt ttcaaaggta atcctgtgtt aatttcagaa attacatcac
    58981 tttttgttcg tcaaatggca gctctttttt taggatataa aacagggttc ggataagttt
    59041 ttttgcaagg tggatgatgg ctacattgta atgttttcct tgttctaatt tagtcttaag
    59101 ataggcctta aaagcaggcg aaaagcgagg gcatgctttg gcagcttgta tgagtaccta
    59161 ccgcagatga ggggaactcc gtttgaccat tcttcctgct aaatcaatct gatctgactg
    59221 ataaatagaa gaatccagtc cagcgaaagc ttgtaattga gcaggattat caaaggcatg
    59281 aatatttcga atctcagcta aaatgaccgc ccctaaacga tccccaatcc cagtaaccgt
    59341 cgtgatgacc gagttgaact cagccatcaa gtcattgaca catgtttccg ccttgtcaat
    59401 gagcctcttg taatgtttga tgttttcatt acacgagata aaacgtctat gcgttatcaa
    59461 actcattacc aattaaaaca aaaagctgtg gttagatcct ttcggaaatt gtcaagcgat
    59521 tggaggaaat gaactaatcc acagcggctt attccaagta taccacttgg gctttggcag
    59581 tagctaactg cgctaaatat aatataagga ggagtaaaat gaagacagtt caattttttt
    59641 ggcattattt taaggtctac aagttctcat ttgtagttgt catcctgatg attgttctgg
    59701 cgacttttgc ccaagccctc tttccagtct tttctggaca agcggtgacg cagctagcca
    59761 atttagttca agcttatcaa aatggcaatc cagaacttgt atggcaaagc ctatcaggaa
    59821 tcatggtcaa tcttggcctg ctggttttgg ttctatttat ctctagtgta atatacatgt
    59881 gtctcatgac gcgcgtgatt gcagaatcga ccaacgagat gcgcaaaggc ctctttggta
    59941 agcttgctca gttgacggtt tctttctttg accgtcgaca agatggcgat atcctgtctc
    60001 attttaccag tgatttggat aatatcctcc aagcctttaa cgaaagcttg attcaggtca
    60061 tgagcaatat tgttttatac attggtctga ttcttgtcat gttttcgaga aatgtgacgc
    60121 tggctctcat caccattgcc agcaccccat tggctttcct tatgctgatt ttcatcgtga
    60181 aaatggcacg caaatacacc aacctccagc agaaagaggt agggaagctc aacgcctata
    60241 tggatgagag catctcaggc caaaaagccg tgattgtgca aggaattcaa gaggatatga
    60301 tggcaggatt tcttgaacaa aatgagcgcg tgcgcaaggc aacctttaaa ggaagaatgt
    60361 tctcaggaat tcttttccct gtcatgaatg ggatgagcct gattaataca gccatcgtca
    60421 tctttgctgg ttcggctgta cttttgaatg ataagtctat tgaaacaagt acagccctag
    60481 gtttgattgt tatgtttgca caattttcac agcagtacta ccagcctatt atccaagttg
    60541 cagcgagttg gggaagcctt cagttggcct ttactggagc tgaacgaatt caggaaatgt
    60601 ttgatgcaga ggaggaaatc cgacctgaaa aggctccaac cttcactaag ttgcaagaaa
    60661 gtgttgaaat cagtcatatc gatttttcat acttgcctga taaacctatt ttgaaagata
    60721 tcagcatttc tgcccctaaa ggccagatga cagcagttgt tgggccgaca ggttcaggaa
    60781 aaacgactat tatgaacctc atcaatcgct tttatgatgt tgatgctggt ggtatttatt
    60841 ttgatggtaa agacattcgt ggctatgatt tagatagtct tagaagcaag gtgggaattg
    60901 tattgcaaga ttcggtcttg tttagcggaa cgattcgaga caatatccga tttggtgtgc
    60961 cagatgctag tcaggaaatg gttgaggtag cagcaaaagc aacccacatt cacgactata
    61021 tcgaaagttt gcctgataag tacgatactc ttattgatga tgaccagagc atcttttcaa
    61081 cagggcagaa gcaattgatt tcaatcgctc gaaccctgat gacagatcca gaagttctca
    61141 ttctcgatga agcaacttca aacgtagata cggtgacaga aagcaagatt cagcatgcca
    61201 tggaggtggt tgtagcaggt agaactagtt tcgtcattgc ccaccgcttg aaaaccattc
    61261 tcaatgcaga tcagattatt gtccttaaag atggagaagt cattgaacgt ggtaaccacc
    61321 atgaactttt gaagctaggt ggcttttatt cagaactcta tcacaatcaa tttgttttcg
    61381 aataagaaag aagttgtcct atgtgggcag ctttttcttg tccataaaaa atgtttatca
    61441 cagccttaaa aaaaacatat tagacgaaag tcattttgag tgatatgata ggactatcgt
    61501 tagcattcga aaggagaggc atcatggcta gaacggttgt aggagttact gcaaatctat
    61561 gtcccgtaga cgcagaaggc aaaatcattc attcatctgt atcttgtaga ttcgcagaga
    61621 tcattcgtca agtcggtggt ctccctttag tcattcctgt tggtgatgag tcagttgtac
    61681 gtgattatgt ggaaatgatt gacaaactca ttttgacagg aggccaaaat gttcatcctc
    61741 agttttatgg agagaaaaag accgtcgaga gcgatgatta caatctggtc cgtgacgaat
    61801 ttgaattggc actcttgaag gaagcgcttc gtcagaataa accaattatg gcaatctgtc
    61861 gcggtgtcca acttgtcaat gttgcctttg gtggaaccct caatcaagaa atcgaaggtc
    61921 actggcaagg actacctttc gggacatctc actctattga gacagtagaa ggaagcgtgg
    61981 tggctaagct atttgggaaa gaaagtcagg tcaattcagt ccatcgtcaa agcattaaag
    62041 atttggcacc caatttccgt gtaactgcta ttgattcaag agaccaaact attgaagcga
    62101 ttgagtctat cgacgagcac cgcattatcg gtttacagtg gcatccagag tttctggtta
    62161 atgaagaaga tggcaattta gaattatttg agtatttatt gaatgaactg taacgattgg
    62221 aatatctggt cgttctttct tttatttttt caaaattttt agaatgtggt attttacgca
    62281 aacgtttgaa ttctgataaa aattggagaa attcgacaaa aaaacttgaa aaaaacgaag
    62341 gtaagcgtta tgatagaaaa gaagaaatat tggaggaaga acatgtcaca tattaaattt
    62401 gattattcaa aagttttaga caaatttgtt gcaccacatg aagtggaata catgcaatca
    62461 caagtaacag cagcagatga attgatccgt aaaggaactg gtgctggtag cgacttcttg
    62521 ggatggttgg accttcctga aaaatacgac cgcgaagaat ttgaccgcat cttgaaagct
    62581 gctgagcaaa tcaagtcaga cagcgatgtt ttggttgtga tcggtattgg tggatcttac
    62641 cttggtgcaa aagcagcaat cgacttcttg aatcaccatt ttgctaactt gcaaacaaaa
    62701 gaagaacgca aagctccaca aatcctttac gcaggaaact caatctcatc tacttacctt
    62761 gctgacttgg tagagtatgt tgcagacaaa gacttctcag taaacgtaat ttctaaatca
    62821 ggtacaacaa ctgaaccagc gattgctttc cgtgtcttta aagaactctt ggttaagaaa
    62881 tacggtcaag aagaagctaa caaacgtatc tatgcaacaa ctgaccgcca aaagggtgct
    62941 gttaaggttg aagcagacgc taacggttgg gaaacatttg ttgttccaga tgatatcggt
    63001 ggacgcttct cagtattgac agccgttggt ttgcttccaa tcgcagcatc aggagctgac
    63061 atcaaagctc ttatggaagg tgcgaatgca gctcgcaaag actacacttc agacaaaatc
    63121 tctgaaaacg aagcttacca atacgcagct gttcgtaaca tcctttatcg taaaggctat
    63181 gcaactgaga tcttggtaaa ctatgagcca tcacttcaat acttctcaga atggtggaaa
    63241 caattggctg gtgaatcaga aggaaaagac caaaaaggta tctacccaac ttcagccaac
    63301 ttctcaactg acttgcactc acttggtcaa tttatccaag aaggaactcg tatcatgttt
    63361 gaaacagttg tccgtgttga caaacctcgt aaaaacgtgc ttattcctac tttggaagaa
    63421 gaccttgacg gacttggtta ccttcaagga aaagacgttg actttgtaaa caaaaaagca
    63481 actgacggtg ttcttcttgc ccacacagat ggtgatgtac caaacatgta tgtgactctt
    63541 ccagagcaag acgctttcac tcttggttac actatctact tcttcgaatt ggcaattgcc
    63601 ctttcaggtt acttgaatgc tatcaaccca tttgaccaac caggtgttga agcttataaa
    63661 cgtaacatgt ttgcccttct tggaaaacca ggatttgaag aattgagcaa agaacttaac
    63721 gcacgtctat aatagaagaa aagagtggtt tacccactct ttttactctc tttatccata
    63781 gaaattggac tcagtcaaga cttgtgatat aatatagaaa gcaaaaaggc agatgcctag
    63841 ataataggag aaactatgtc aaaagatatc cgcgtacgtt acgcaccaag tccaacagga
    63901 ctactacaca tcggaaatgc tcgtacagca ttgtttaatt acttgtatgc gcgccatcat
    63961 ggtggaacat ttctcatccg tatcgaagat actgaccgta aacgccatgt cgaggatggt
    64021 gaacgttcac aacttgaaaa ccttcgctgg ttaggcatgg attgggatga aagtccagaa
    64081 tcacatgaga attatcgcca gtctgagcgt ttagacttgt atcaaaaata cattgaccaa
    64141 ctattagctg aaggaaaagc ctataaatct tacgttacag aagaagagtt ggcagctgaa
    64201 cgcgaacgcc aagaagtagc tggcgaaaca ccacgctaca tcaatgaata ccttggtatg
    64261 agtgaagaag aaaaagcagc ttacatcgca gaacgtgaag cagcagggat catcccaact
    64321 gttcgtttgg ctgtcaatga gtcaggtatc tacaagtggc atgatatggt caaaggcgat
    64381 atcgaatttg aaggtggcaa tatcggtggt gactgggtta tccaaaagaa agacggttac
    64441 ccaacttaca actttgccgt tgttatcgat gaccacgata tgcaaatctc tcatgttatc
    64501 cgtggagatg accatattgc taatacacca aaacagctta tggtctatga agctcttggt
    64561 tgggaagctc cagagttcgg tcacatgacc ttgattatca actctgagac tggtaagaag
    64621 ttatctaaac gtgatactaa tacacttcaa tttatcgaag attaccgaaa gaaaggttac
    64681 cttccagaag cagtctttaa ctttattgct cttcttggtt ggaacccagg tggtgaagat
    64741 gagattttct ctcgtgaaga actcattaaa ctttttgatg aaaaccgcct cagcaagtca
    64801 ccagcagcct ttgatcagaa aaaactagac tggatgagca atgattatat caagaatgca
    64861 gaccttgaaa ccatctttga aatggcaaaa ccattcttag aggaagcagg ccgtttgact
    64921 gacaaggctg aaaaattagt tgagctctat aaaccacaaa tgaaatcagt agatgagatt
    64981 atcccattga cagatctttt cttctcagat ttcccagaat tgacagaagc agagcgcgaa
    65041 gtcatgacgg gtgaaacagt tccaacagtt cttgaagcat tcaaagcaaa acttgaagcg
    65101 atgacagatg ataaatttgt gacagaaaat atcttcccac aaattaaagc agttcaaaaa
    65161 gaaacaggta ttaaagggaa aaatcttttc atgcctattc gtatcgcagt ttcaggcgaa
    65221 atgcatgggc cagaattacc agatacaatt ttcttgcttg gacgtgaaaa atcaattcag
    65281 catatcgaaa acatgctaaa agaaatctct aaataaagag gatacaataa tggacatctg
    65341 ggaaaagatg tacgaagaag cacagaaact atacaatcca catgaagtat cagactttgt
    65401 ttatgccaat catgttgtag ctgcagtaga agcagaagat ggacaaatat ttacaggatt
    65461 ctgtatggag ggaacctgtg gtgttttcca tctctgcgca gaacgggcgg ccctcttcaa
    65521 tatgtaccaa ttttcaggac aaactaaggt taagaaagta ttagcctttc gagacaaacc
    65581 accttatggt ggaagttcag ccatgccttg cggtgcttgt agagaattcc ttttagaact
    65641 taatgctgaa aataaagatg cagaattcat gatggactat aatataagaa aaacagttaa
    65701 agtcgcagaa ctaatccctt attggtgggg agaagaacgt gcttctaagt ttaatgagcg
    65761 atagaagagt cagtataatt ttggctcttt ttactataag ttgaaaaaat aaaaaaaatt
    65821 agaaaaagt
//
LOCUS       DAVHIZ010000003        65320 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.003, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000003 DAVHIZ010000000
VERSION     DAVHIZ010000003.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 65320)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 65320)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..65320
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.003"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(431..1693)
                     /locus_tag="VVO18_000174"
     CDS             complement(431..1693)
                     /locus_tag="VVO18_000174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="divalent metal cation transporter"
                     /protein_id="HEU5585398.1"
                     /translation="MSQAISLNQSTWASKLKAMGPGILMATAAVGGSHIVSSTQAGGS
                     YGWSLLLLVILANVFKYPFFRFGAEYTADTGKTLVEGYAEKGKLYLWIFFILNVFSAM
                     VNTAGVAILCSAIIASAFPMIGLSITQWSLILVAIIWAMLLFGGYKLLDGMVKWIMSA
                     LTIATVLAVIIAAVKHPEYSSDFVEKTPWQMAALPFIVSLLGWMPAPIEISAINSLWS
                     AEKRKTVNFNTEDALFDFNTGYIGTAILAVFFVALGALIQYPTGQAVEAASAKYISQF
                     VGMYASVLGEWSRYLITFIAFLCIFGTVITVIDGYSRVNQESLRLLISQKEDNRKSLN
                     IWMTITAIIGIVIIKFFAGQVSTMLRFAMIGSFLTTPFFALLNYALVTRENKNLPSWL
                     KHLAIAGLIFLFGFAIFFIYALAIGKAG"
     gene            complement(2003..2461)
                     /locus_tag="VVO18_000175"
     CDS             complement(2003..2461)
                     /locus_tag="VVO18_000175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3021 domain-containing protein"
                     /protein_id="HEU5585399.1"
                     /translation="MKKQVFHDAAAGVLIGLILSILFSLIYAPNTYAPLNPYSLIGQV
                     MDQHQVHGALVLLYCTLIWATIGMLFNFGNRLFSRDWSMLRATLTHFFLMLAGFVPLA
                     TLAGWFPFHWIFYLQLIIEFAIVYLIIWAILYKREAKKVDHINQLLEHRK"
     gene            complement(2458..2898)
                     /locus_tag="VVO18_000176"
     CDS             complement(2458..2898)
                     /locus_tag="VVO18_000176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000861967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585400.1"
                     /translation="MKVELQISETYEEEKLIVQAPQPTDKVQKVIEFAENLDQREKIK
                     GKIDDQVYLVEIGKIQRFYIENRKVLAETASQTYSIDLRLYQVLKLLPTNFIQISQSE
                     IINIDSISHLKLTPNGLIEIFLKNESFTYSSRRYLKTIKEKLEL"
     gene            3254..5203
                     /gene="mutL"
                     /locus_tag="VVO18_000177"
     CDS             3254..5203
                     /gene="mutL"
                     /locus_tag="VVO18_000177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA mismatch repair endonuclease MutL"
                     /protein_id="HEU5585401.1"
                     /translation="MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQII
                     IEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSKIKNQADLFRIRTLGFRGEALPS
                     IASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
                     MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLISA
                     KKMIEIENSDLDFEISGFVSLPELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKL
                     MVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSEAIANSLKEQTLIPD
                     ALENLAKSTVRNREKVDQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLT
                     LFAKETLDRLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELE
                     FFGQMHGTYLFAQGRDGLYIIDQHAAQERVKYEEYRESIGNVDQSQQQLLVPYIFEFP
                     ADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCDMLLLTK
                     EVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHF
                     TKSDMEKMFRRIQENHTSLRELGKY"
     gene            complement(5528..5995)
                     /locus_tag="VVO18_000178"
     CDS             complement(5528..5995)
                     /locus_tag="VVO18_000178"
                     /EC_number="2.5.1.78"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001099498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="HEU5585402.1"
                     /translation="MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVN
                     EKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQ
                     ISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA"
     gene            complement(5996..7201)
                     /locus_tag="VVO18_000179"
     CDS             complement(5996..7201)
                     /locus_tag="VVO18_000179"
                     /EC_number="3.5.4.25"
                     /EC_number="4.1.99.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP
                     cyclohydrolase II"
                     /protein_id="HEU5585403.1"
                     /translation="MEYRKIQEALEALQKGRLVLVIDDKDRENEGDLICSAQAATTEN
                     VNFMATYAKGLICMPMSESLANQLMLSPMVENNTDNHKTAFTVSIDYKETTTGISAEE
                     RGLTARMCVAEDITPSDFRRPGHMFPLIAKKGGVLERNGHTEATVDLLKLAGLKECGL
                     CCEIMNHDGKMMRIDDLIQFSKKHNIPLITIKELQEYRKAYDQLVERVSTVNMPTRYG
                     NFKAISYIDKLNGEHHLALIMGNIEDEANVLCRVHSECLTGDVLGSLRCDCGQQFDKA
                     MKIIVENGSGVLLYLRQEGRGIGLINKLKAYHLQDQGMDTLDANLALGFEGDLREYHI
                     GAQMLKDLGLQSLHLLTNNPDKVEQLEKYGITISSRISIEIEANPYDSFYLETKKNRM
                     GHILNMEEK"
     gene            complement(7221..7856)
                     /gene="ribE"
                     /locus_tag="VVO18_000180"
     CDS             complement(7221..7856)
                     /gene="ribE"
                     /locus_tag="VVO18_000180"
                     /EC_number="2.5.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000493842.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="riboflavin synthase"
                     /protein_id="HEU5585404.1"
                     /translation="MFTGIIEEIGKVERIQKDSRNCKLSIKASKILTDIHLGDSIAVN
                     GICLTVTHFNHQSFTVDVMNETWSRTALTLLKHGSEVNLERALSVNGRLGGHVVTGHI
                     DGTGKISSIKKDDNAVWYQINTQKEILDLIVEKGSITIDGISLTVAKVSKVNFSVSVI
                     PHTLKQTILKSKQVGSTVNLENDILGKYVQKLMDNSPKSEISKELLYQNGF"
     gene            complement(7841..8941)
                     /gene="ribD"
                     /locus_tag="VVO18_000181"
     CDS             complement(7841..8941)
                     /gene="ribD"
                     /locus_tag="VVO18_000181"
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil
                     reductase RibD"
                     /protein_id="HEU5585405.1"
                     /translation="MSDSKYMKLAIKLAQKGAGYVNPNPMVGAVIVKDNHIIGQGYHE
                     FFGGSHAERNALKNCRESPVGATLYVTLEPCCHFGKTPPCIDAIIDSGITRVVIGSLD
                     CNPIVSGKGVKILEENNLQVTVGILENECLNLIKSFRKYITQHVPYVFMKYAMTIDGK
                     IATKTNQSKWITEEEARKHVHQLRHHVSAIMVGVNTVIQDDPLLTCRLEEGKNPIRII
                     CDTHLRTPLTSKIVKTANDIKTYIATSSEDKNKMKLYQNHGCEILSIKKKGNHIDLSS
                     LMQHLGNMQIDSLVLEGGSLMNWSALEQQIVDELKIYIAPKIFGGSAKFPVGGEGISL
                     PNDAIRLKPYAFSQIGNDYLIESEVIYPCSQE"
     regulatory      complement(9075..9189)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            9346..9939
                     /gene="ruvA"
                     /locus_tag="VVO18_000182"
     CDS             9346..9939
                     /gene="ruvA"
                     /locus_tag="VVO18_000182"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000271492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="HEU5585406.1"
                     /translation="MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQED
                     QIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIE
                     TKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDDLPAKIAVQASAENQELEEAMEAM
                     LALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK"
     gene            9949..10512
                     /locus_tag="VVO18_000183"
     CDS             9949..10512
                     /locus_tag="VVO18_000183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-3-methyladenine glycosylase I"
                     /protein_id="HEU5585407.1"
                     /translation="MTKRCSWVKMTNPLYIAYHDEEWGQPLHDDQALFELLCMETYQA
                     GLSWETVLNKRQAFREAFHSYQIHSVAEMTDTELEAMLENPAIIRNRAKIFATRANAQ
                     AFLQLQAEYGSFDAYLWSFVEGKTVVNDVPDYRQAPAKTPLSEKLAKDLKKRDFKFTG
                     PVAVLSFLQAAGLVDDHENDCEWKGLK"
     gene            10509..11186
                     /locus_tag="VVO18_000184"
     CDS             10509..11186
                     /locus_tag="VVO18_000184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000987430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5585408.1"
                     /translation="MMSNKNKGILIFAILYTVLFVFDGVKLLASLMPSAIANYLVYVV
                     LALYGSFLFKDRLIQQWKEIRKTKRKFFFGVLTGWLFLILMTVVFEFVSEMLKQFVGL
                     DGQGLNQSNIQSTFQEQPLLIAVFACVIGPLVEELFFRQVLLHYLQERLSGLLSIILV
                     GLVFALTHMHSLALSEWIGAVGYLGGGLAFSIIYVKEKENIYYPLLVHMLSNSLSLII
                     LAISIVK"
     gene            complement(11323..12354)
                     /locus_tag="VVO18_000185"
     CDS             complement(11323..12354)
                     /locus_tag="VVO18_000185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000255096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LD-carboxypeptidase"
                     /protein_id="HEU5585409.1"
                     /translation="MVSTIGIVSLSSGIIGEDFVKHEVDLGIQRLKDLGLNPIFLPHS
                     LKGLDFIKDHPEARAEDLIHAFSDDSIDMILCAIGGDDTYRLLPYLFENDQLQKVIKQ
                     KIFLGFSDTTMNHLMLHKLGIKTFYGQSFLADICELDKEMLAYSLHYFKELIETGRIS
                     EIRPSDVWYEERTDFSPTALGTPRVSHTNTGFDLLQGSAQFEGKILGGCLESLYDIFD
                     NSRYADSTELCQKYKLFPDLSDWEGKILLLETSEEKPKPEDFKKMLLTLKDTGIFAVI
                     NGLLVGKPMDETFHDDYKEALLDIIDSNIPIVYNLNVGHATPRAIVPFGVHAHVDAQE
                     QVILFDYNK"
     gene            complement(12609..13292)
                     /locus_tag="VVO18_000186"
     CDS             complement(12609..13292)
                     /locus_tag="VVO18_000186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1129 domain-containing protein"
                     /protein_id="HEU5585410.1"
                     /translation="MSQIDLQKLTKKNQEFVHIATQQFIKDGKTDAEIQTIFEEVIPQ
                     ILEEQSKGTTARSLYGAPTHWAHSFTVKEQYEKEHPKENDDPKLMIMDSALFITSLFA
                     LVSALTTFFAADQAFGYGLITLLLVGLVGGFAFYLMYYFVYQYYGPDMDRSQRPPFWK
                     SVLVILASMFLWLLVFFATSFLPASLNPVLDPLPLAIIGAALLALRFYLKKRLNIRSA
                     SAGPTRYQE"
     gene            complement(13304..14248)
                     /locus_tag="VVO18_000187"
     CDS             complement(13304..14248)
                     /locus_tag="VVO18_000187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000815632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEU5585411.1"
                     /translation="MKQVFLSTTTEFKEIDTLEPGTWINLVNPTQNESLEIANTFDID
                     IADLRAPLDAEEMSRITIEDEYTLIIVDVPVTEERNNRTYYVTIPLGIIITEETIITT
                     CLEPLPVLDVFINRRLRNFYTFMRSRFIFQILYRNAELYLTALRSIDRKSEQIESQLH
                     QSTRNEELIELMELEKTIVYFKASLKTNERVIKKLTSSTSNIKKYLEDEDLLEDTLIE
                     TQQAIEMADIYGNVLHSMTETFASIISNNQNNIMKTLALVTIVMSIPTMVFSAYGMNF
                     KDNEIPLNGEPNAFWLIVFIAFAMSVSLTLYLIHKKWF"
     gene            complement(14409..15575)
                     /locus_tag="VVO18_000188"
     CDS             complement(14409..15575)
                     /locus_tag="VVO18_000188"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEU5585412.1"
                     /translation="MKITEVIKKDGSKVYRANVYLGVDQVTGKKVKTKVTGRTQKEVK
                     QKANQEKIAFQKAGSTRQKAVTIKNYQELATLWLESYKNTVKPNTQGNVKKLIDNHIL
                     PIFGAYKLDKLTTPLIQSIINELADKTNRGEKAAFLHYDKIHALNKRILQYGVTMQAI
                     PSNPARDVVLPRNTQKAKRKKVKHFENQELKKFLGYLDNLDTHRYRYYYETTLYKFLL
                     ATGCRINEALALSWSDIDLDNAVVHITKTLNRDIEINSPKSKASYRDIDIDQATVSML
                     KQYKLRQTKEAWKIGQRERVVFSDFIHEYPSSSRLKRRLQTHFKRADVPNIGFHGFRH
                     THASLLLNSGIPYKELQYRLGHSTLSMTMDIYSHLSKENAKKAVSFYETALKAL"
     gene            complement(15660..17174)
                     /locus_tag="VVO18_000189"
     CDS             complement(15660..17174)
                     /locus_tag="VVO18_000189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA binding domain-containing protein"
                     /protein_id="HEU5585413.1"
                     /translation="MRKYDIPKLLLSGENQGVEFKEAKNSFPKDGMKTICSFANTNNG
                     LLILGVSENTKNKDFYISGVNDPDKVLDELYSLLNNPNKINRNVINEESVEVVNIKGK
                     EIVIIPVNKVDYKDKPIYLNDNIASTYFRQGTGDFRCSQEQINSMLRDSAKESFDSTL
                     IQDFSILDLDTETIKLYREKFDNINAEHPFSKLDNEQFLIKINALRRDRKDDKIKPTV
                     AGLLIFGTHNSIKEFIPHYNVEYVLKEFSENNRFKDRVIYDGTWGEDNLFNFFYLVIE
                     KLYLTLNDNSNIQENSMNRIGISKLRIAIREAFINSLIHSDYKSEKGIMIIRYPDRYI
                     FTNGGTLRIDIKDFFSGAHSDPRNYLIQEIFRFLNLCEKAGTGIPKIMEAVKESHLKY
                     PNLRTELDSVEFTLWDTSLIDNLDIDNEYEKKILELIIEHRFVTREALEEKLKIHKNT
                     ILKYLKKLVEKQAIDKFKSGRQYVYFITQNQDPEFQKYNHINAMYSLLEEIKRK"
     gene            complement(17335..18048)
                     /locus_tag="VVO18_000190"
     CDS             complement(17335..18048)
                     /locus_tag="VVO18_000190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001107589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5585414.1"
                     /translation="MAKNSPQDLKNREYFSNNLNRVMKEKGIRQIDLHNALEIPKSTI
                     TGYVKGRSMPTSGNLQKLADYLGVKKSDLDPRFSDKDVYKEFLYMLDKQLDEEKYLVK
                     NVSKDKIFQKVKEREKRDKEIIELAKSKNFPISPEEFLTTITESLNEYNPKDNYEVLN
                     ALALKTSNILFWLDIVFQKTSSEFYIVFEDKEFNQEYYNKLYKKFENLFEEIKSLALQ
                     EAKKDKENLDDFALLWGID"
     gene            18201..18431
                     /locus_tag="VVO18_000191"
     CDS             18201..18431
                     /locus_tag="VVO18_000191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5585415.1"
                     /translation="MAQWTLRACRVNAGFTLRQVAKKVNKNFQTISKYEKDSTLIPFE
                     LLKELSELYQVKLDDIFLGDSTKKIELNQKEI"
     gene            18447..19073
                     /locus_tag="VVO18_000192"
     CDS             18447..19073
                     /locus_tag="VVO18_000192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424668.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rha family transcriptional regulator"
                     /protein_id="HEU5585416.1"
                     /translation="MELVYMDGKKEPYTLSSIVAECAEVKHRHLKILLNKHREDFESF
                     GKVQFKISPSESGQNVRDYILNEQQATLLITYLRNTEPVKEFKKNLVKAFFEMREELS
                     KFRMQRALEKPKRKTLHDSIETWEAKPKHAHSTMNNLLLKAVTDMNAKQLREERGGYN
                     GIDSLTSDELEQYQAFEDMVIAMIGLNMSYQEIKAMAFRNKKTRQRSA"
     gene            19445..19897
                     /locus_tag="VVO18_000193"
     CDS             19445..19897
                     /locus_tag="VVO18_000193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000141097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585417.1"
                     /translation="MTETTYENLTRHIDRISAEMREIGEKNGLSRLSLLANQTKFIKE
                     NLHRLLWIELPELNDSHKIEAVSKSTTGMFFHAGIFEMDAMRQAFFKRQAMHFFDNEA
                     EQQAYIEHAEKEYLEATITLKDILFNSKNGTQRVNKSCLIEKFEEAMQ"
     gene            19894..20094
                     /locus_tag="VVO18_000194"
     CDS             19894..20094
                     /locus_tag="VVO18_000194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000174331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585418.1"
                     /translation="MTLNLDNMTQAEFDEVMAEIKEKRPNLFQFIADFVDRKVSTEEV
                     DEYLKMKHEKQVEFIKNYQARA"
     gene            20096..20311
                     /locus_tag="VVO18_000195"
     CDS             20096..20311
                     /locus_tag="VVO18_000195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585419.1"
                     /translation="MNELDLTNTQSVIFMVVLIGLLLYLNHRDRKKSAQFERENQQRI
                     ETPSEDLSPDYGRYIQLAGVRVYGGTE"
     gene            20308..20649
                     /locus_tag="VVO18_000196"
     CDS             20308..20649
                     /locus_tag="VVO18_000196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU5585420.1"
                     /translation="MSLSENDKRVLRLIKVGAENSITGAEISLITKLAERTVQDIISR
                     LITRHSVPIVGVRHGTFRGYFIPANKEELLDGAKAFYNQVQEEQKRLTVLLNADLESY
                     KETLKEVGGYV"
     gene            20642..20923
                     /locus_tag="VVO18_000197"
     CDS             20642..20923
                     /locus_tag="VVO18_000197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000492137.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HEU5585421.1"
                     /translation="MFSLSRESEQDLAHGILEVVERYLEARDTVKPRLTGLISAQEVM
                     DELDIKYMTLQKWEKAGLRRYQPPLEDTRKIYYKISDIWKFLGVENGKV"
     gene            21058..21924
                     /locus_tag="VVO18_000198"
     CDS             21058..21924
                     /locus_tag="VVO18_000198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase alpha helix C-terminal domain-containing
                     protein"
                     /protein_id="HEU5585422.1"
                     /translation="MTIYEAKGFQSNLVYPFDKIEPFQYIERFKPLVVPEGADIEEYK
                     RTQAPYCISGKVTPEKHGSYKRNNSSLIYRDLIFLDYDDIQGTSEGFIKAISSALFGY
                     SYILYPTIKHSLEKPRFRLVVKPDNVMNEATYKQVVKEIADKIGLPFDMASLTWSQLQ
                     GLPVTTGDPASYQKIVEHGLDYPVPQTTAEPVKQNAASLPYTPRPSGQKSMTMRIIDT
                     LFNGFGDEGGRNVALTRFVGLLFNKWVDCDLETAYELTKIANSVTVEPLPIEELDRTF
                     SSIARAEYRKRG"
     gene            21977..23446
                     /locus_tag="VVO18_000199"
     CDS             21977..23446
                     /locus_tag="VVO18_000199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase family protein"
                     /protein_id="HEU5585423.1"
                     /translation="MEQEHPPRTMKELENRIFKAGEEWRAEHTETKVNENTGDVTEKV
                     AMPQTFTVAKILSEIVTFTFISKSNIPDYSLLYIYDLDEGIYTASNDLFNLLCKTFDV
                     RIKPREWPQIKLMVRTLAKIRKPLESANLIPVQNGIINLETKELLPFSPKYVITSKIS
                     TAYHAPKRVPTDREGKTFDDWLNSIACNDSELVTLFWQIILEAIDPNHTRNKFAIFYG
                     DGNNGKGTFQRFLINLIGESNISALKPAQFAEKHNLETLVGKVCNIGDEAPNEYLKNP
                     SDLMSITSGDTVLVNPKGRPAFEATFKLFNIFSGNYIPNGGNKTKGWYRRIMIVPFNA
                     DFNGEKEKPWIKNEFLANKEVLEYALYKAINQEPFTHFIEPKAVKGLLEEYQEDNDYL
                     LSWVKHEYMEKGWHELDVVPVFIVTRSLKHYAEDMGIPKPNVYGAGKETIKHLQQLTP
                     NRYSLRKKRVSPEDFEKLEAWDVDKIKMRTPQHSITKQE"
     gene            23799..23966
                     /locus_tag="VVO18_000200"
     CDS             23799..23966
                     /locus_tag="VVO18_000200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585424.1"
                     /translation="MKVKLFEYTRRWEKEDFEKEIDDFMATVEVLDVKFSGTPSSESF
                     NSVAIVLVLYR"
     gene            24050..24580
                     /locus_tag="VVO18_000201"
     CDS             24050..24580
                     /locus_tag="VVO18_000201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585425.1"
                     /translation="MTLKTFSSKAKTFTFTYEFKDLDTALVAGHALLGYMTGTYCQPV
                     ISLTYKDKGTLVAEYVEDHKLNKTFKRICDSFKDYHKQPGEAEAFEERYKRERVLQLK
                     ESEDFESLLNKVTDYELELLDYADRLLSDKPIPMDSMTAFATLEMLGDESISLLQKLD
                     VEGEYKGLAGYTEHLK"
     gene            24651..25160
                     /locus_tag="VVO18_000202"
     CDS             24651..25160
                     /locus_tag="VVO18_000202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000811078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585426.1"
                     /translation="MKQLAIEAITKPMKLRGISKGIAELDGQRLEIDLDSLMIDFGGE
                     SFELDRIAGTKGGNRYFFLCPDCGRRCRLLYKRYLYFSCGTCLDIHKHTLNRSKTDCQ
                     YYWELALKEARKVEPGWSPRRGGYMFDSFPERPKYMKQKRYYKHYQKFINYTRKGDSF
                     WLNGLSSLR"
     gene            26356..26775
                     /locus_tag="VVO18_000203"
     CDS             26356..26775
                     /locus_tag="VVO18_000203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1492 domain-containing protein"
                     /protein_id="HEU5585427.1"
                     /translation="MTPEQVKEKLEGVKWINKEIKGLYLELETLEGGIIKKPTLSHSR
                     VQTSRENKTENNLISVLKLKEDTLQRIERLTEERMKISELIDKLANPLERSVLRLFYL
                     NDLVVSEVAEEIDRSNTTVYIIRQKAIEHLTGIVNGD"
     gene            27264..30095
                     /gene="uvrA"
                     /locus_tag="VVO18_000204"
     CDS             27264..30095
                     /gene="uvrA"
                     /locus_tag="VVO18_000204"
                     /EC_number="3.1.25.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="HEU5585428.1"
                     /translation="MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFD
                     TLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTT
                     TEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK
                     GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRL
                     FDSIEAALRIAEGYVIIDTMDDSELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCS
                     ECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNMLEQAMKVFGVAMDKP
                     FEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYT
                     RTQMRLYMNELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTL
                     SENEAIIARPILKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLS
                     GVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLIDVGPGA
                     GVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVTGARENNL
                     QNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHV
                     DRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRC
                     EACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVE
                     FFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYIL
                     DEPTTGLHTEDIARLLKVLARFVDAGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGT
                     IIVTGTPEEVAANEASYTGHYLKGKLHHE"
     gene            30088..31149
                     /locus_tag="VVO18_000205"
     CDS             30088..31149
                     /locus_tag="VVO18_000205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466358.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase P family protein"
                     /protein_id="HEU5585429.1"
                     /translation="MNKRVQAFLAKMQEKELDGIIINNLKNVYYLTGFWGSNGTVFIS
                     RDRQVLVTDSRYIIAAKQETSGFEIVADRDELAVIAGIVKDMGLTRIGFEDEISVSYY
                     HRMQAAFAGLNLLPQTQFVEGLRMIKDEAEIAAIRKACSISDQAFRDALDFIKPGKTE
                     IEIANFLDFRMRELGASGLSFDTILASGINSSKPHAHPMHKPVELGEAITMDFGCLYD
                     HYVSDMTRTIYLGHVSDEQAEIYNTVLKANQALIDQAKAGLGFRDFDKIPRDIIIEAG
                     YGDYFTHGIGHGIGLDIHEEPYFSQTSTETIKTGMALTDEPGIYIEGKYGVRIEDDIL
                     ITETGCELLTLAPKELIVI"
     gene            31281..31679
                     /gene="spx"
                     /locus_tag="VVO18_000206"
     CDS             31281..31679
                     /gene="spx"
                     /locus_tag="VVO18_000206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017768833.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator Spx"
                     /protein_id="HEU5585430.1"
                     /translation="MIKIYTVSSCTSCKKAKTWLNAHQLSYKEQNLGKEGITREELLD
                     ILTKTDNGIASIVSSKNRYAKALGVDIEDLSVNEVLNLIMETPRILKSPILVDEKRLQ
                     VGYKEDDIRAFLPRSVRNVENAEARLRAAL"
     gene            31745..32314
                     /locus_tag="VVO18_000207"
     CDS             31745..32314
                     /locus_tag="VVO18_000207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="HEU5585431.1"
                     /translation="MKKIVLVSLAFLFVLVGCGQKKETGPATKTEKDTLQSALPVIEN
                     AEKNTVVTKTLVLPKSDDGSQQTQTITYKDKTFLSLAIQQKRPVSDELKTYIDQHGVE
                     ETQKALLEAEEKDKSIIEARKLAGFKLETKLLSATELQTTTSFDFQVLDVKKASQLEH
                     LKNIGLENLLKNEPSKYISDRLANGATEQ"
     gene            32401..32667
                     /locus_tag="VVO18_000208"
     CDS             32401..32667
                     /locus_tag="VVO18_000208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IreB family regulatory phosphoprotein"
                     /protein_id="HEU5585432.1"
                     /translation="MGFTEETVRFKLDDSNKKEISETLTDVYASLNDKGYNPINQIVG
                     YVLSGDPAYVPRYNNARNQIRKYERDEIVEELVRYYLKGQGVDL"
     gene            32671..33090
                     /gene="ruvX"
                     /locus_tag="VVO18_000209"
     CDS             32671..33090
                     /gene="ruvX"
                     /locus_tag="VVO18_000209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002939356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RuvX"
                     /protein_id="HEU5585433.1"
                     /translation="MRIMGLDVGSKTVGVAISDPLGFTAQGLEIIQINEEQGKFGFDR
                     VKELVDTYKVERFVVGLPKNMNNTSGPRVEASQAYGAKLEEFFGLPVDYQDERLTTVA
                     AERMLIEQADISRNKRKKVIDKLAAQLILQNYLDRKF"
     gene            33106..33411
                     /locus_tag="VVO18_000210"
     CDS             33106..33411
                     /locus_tag="VVO18_000210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1292 domain-containing protein"
                     /protein_id="HEU5585434.1"
                     /translation="MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYV
                     LLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE"
     gene            33719..34969
                     /locus_tag="VVO18_000211"
     CDS             33719..34969
                     /locus_tag="VVO18_000211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000464354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEU5585435.1"
                     /translation="MFEVEEWLHSRIGLNFRSGLGRIQQAVDLLGNPEQSYPIIHVTG
                     TNGKGSTIAFIRELFMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLADQVKE
                     MEKTLLQTPDQLSFFELLTLVAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVIT
                     SIGLDHQETLGDSLEAIAEQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVDLYQA
                     GQDFLMLNGDFSSSLLNLSQLNIGLEGVYQQENAALALQTFLLFMGEGKEAVDEQAVR
                     KALEQTHWAGRLERIRPQIYLDGAHNLPALTRLVEFIKEKEQEGYRPQILFGALKRKD
                     YQGMLGYLTEKLPQVELKVTGFDYQGALDERDVTGYDIVSSYREFISDFEERADAQDL
                     LFVTGSLYFISEVRGYLLDREQIN"
     gene            34966..35508
                     /locus_tag="VVO18_000212"
     CDS             34966..35508
                     /locus_tag="VVO18_000212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipocalin/fatty acid-binding family protein"
                     /protein_id="HEU5585436.1"
                     /translation="MTPLFELVILGELLVRENFSKLVAERKFIMKLKRFTLSLASLAS
                     FSLLVACSQRAQQVQQPVAQQVQQPAQQNTNTANAGGNQNQAAPVQNQPVAQPTDIDG
                     TYTGQDDGDRITLVVTGTTGTWTELESDGDQKVKQVTFDSANQRMIIGDDVKIYTVNG
                     NQIVVDDMDRDPSDQIVLTK"
     gene            35654..37186
                     /gene="cls"
                     /locus_tag="VVO18_000213"
     CDS             35654..37186
                     /gene="cls"
                     /locus_tag="VVO18_000213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000877342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cardiolipin synthase"
                     /protein_id="HEU5585437.1"
                     /translation="MKYRKFQLLMSKYGFSLSIMLLELCLVFGLFLYLGRMAPILWIT
                     VLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKK
                     LGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWK
                     KMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTG
                     DYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHV
                     ERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPY
                     GSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRII
                     TPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYR
                     SLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAP
                     IL"
     gene            37264..37407
                     /locus_tag="VVO18_000214"
     CDS             37264..37407
                     /locus_tag="VVO18_000214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000956126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585438.1"
                     /translation="MLTKEEVNDMIEFKQTHLHRFREIETFVKLCKKSLKQPSQADNP
                     RTF"
     gene            37444..38982
                     /locus_tag="VVO18_000215"
     CDS             37444..38982
                     /locus_tag="VVO18_000215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844448.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEU5585439.1"
                     /translation="MSVYGRVEEVHKENREPLEYQIEQESHHRESSRLPLVKILLWST
                     LVTGITLGVPLLLDLMSAQEVQDFYAGWALHQTGKIYSDYYGSQGLLYYLLTYVSQGG
                     FFFAIFEWLALVAGGFFLFRSADTLTNQGDQAGQLVTIFYMLVTGLAFGGGYATLLAL
                     PFLFAAFSLVAAYLSNPSHDKGFVRIGLALAGGFFFAPLSSLLFIAVVSLGLLVFNLG
                     HRRFAHGFYQFLAVALGFSLVFYPTAYYSAATGSFGDAISGIRYPIDSIRFDFTSKIL
                     ENMFFYGLLSLGLGFVVCIFLGLFQSKPFKLYVISVPASLVVILGLILLFFSQEPLHA
                     SYLMVVFPVFLLLLVTNIKSQQRGRSARRSRRETPVSLWSRFFKGNLYLLVFGFVYLL
                     SVPFLMKFVLYPVPYQERNRLADLVKEETNTEDAIYAWDDTATLYRKSERLSPSAILS
                     PLHYTATEENRNKLLNDLKEKQPKVIVVNDKVEVWSEVETLLKENYQQVKTDYSEFKV
                     YKIK"
     gene            39102..41309
                     /gene="nrdD"
                     /locus_tag="VVO18_000216"
     CDS             39102..41309
                     /gene="nrdD"
                     /locus_tag="VVO18_000216"
                     /EC_number="1.17.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004239081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase"
                     /protein_id="HEU5585440.1"
                     /translation="MIALEEKITILPTLFVEKRDGRRVVFDVDKIDKALHKAADKVMD
                     VTPLVEKRLNDLTERIITEIHSRFPQGIKIYEIQNIVEHELLEAKEYALAEEYITYRT
                     QRDFERSKATDINFSIHKLLNKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLQML
                     PKHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLENGFKIGNAEVESPKSIQTA
                     TAQISQIIANVASSQYGGCSADRIDEILAPYAEKNYQKHLKDAEEWVLPEKREDYAWK
                     KTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTSRFEREIQKAILNIRIKGLG
                     SEHRTAIFPKLIFTLKRGLNLEEGTPNYDIKQLALECATKRMYPDVLSYDKIVDLTGS
                     FKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESEGDMNKFWEIFNERM
                     NIAEDALVYRVERTKEATPANAPILYQYGAFGHRLGKEESVDQLFKNRRATVSLGYIG
                     LYEVATVFFGNSWESNPDAKEFTLDIIHDMKRRVEEWSDQYGYHFSIYSTPSESLTDR
                     FCRLDIDKFGSIPDITDKEYYTNSFHYDVRKNPTPFEKLDFEKVYPEAGASGGFIHYC
                     EYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDRCYKCDFEGDFEPTERGFACPNCGN
                     SDPKTVDVVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQVTN"
     gene            41341..41481
                     /locus_tag="VVO18_000217"
     CDS             41341..41481
                     /locus_tag="VVO18_000217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821483.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonucleoside-triphosphate reductase"
                     /protein_id="HEU5585441.1"
                     /translation="MVKRTCGYLGNPQARPMVNGRHKEIAARVKHMNGSTIKIAGHQV
                     TN"
     gene            41493..41633
                     /locus_tag="VVO18_000218"
     CDS             41493..41633
                     /locus_tag="VVO18_000218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000521630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585442.1"
                     /translation="MGKYQLDDKGRAQVTRYHEKHSKGGAGKKERLLSFREQFLNKNK
                     KK"
     gene            41677..42183
                     /locus_tag="VVO18_000219"
     CDS             41677..42183
                     /locus_tag="VVO18_000219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000423398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585443.1"
                     /translation="MELRRPRLADKKAVLDMMTEFEKSQSAHDGGFWDTENFVYEEWL
                     ESNQEQEMGINLPEGWVPAIQLVAFSEKGQAVGFLNLRLRLSNFLLEEGGHIGYSIRP
                     SERGKGYAKETLRQGLQVAKEKNIKKALVTCSVNNPASRAVILANGGIFEDAHNGVER
                     YWIEVANE"
     gene            42176..42766
                     /gene="nrdG"
                     /locus_tag="VVO18_000220"
     CDS             42176..42766
                     /gene="nrdG"
                     /locus_tag="VVO18_000220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001064213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anaerobic ribonucleoside-triphosphate reductase
                     activating protein"
                     /protein_id="HEU5585444.1"
                     /translation="MNNPKPQEWKSEELSQGRIIDYKAFNFVDGEGVRNSLYVSGCMF
                     HCEGCYNVATWSFNAGILYTAELEEQIMADLAQPYVQGLTLLGGEPFLNTGILLPLVK
                     RIRKELPDKDIWSWTGYTWEEMMLETPDKLELLSLIDILVDGRYDRTKRNLMLQFRGS
                     SNQRIIDVQKSLKSGQVVIWDKLNDGKESYEQVKRE"
     gene            42763..43380
                     /locus_tag="VVO18_000221"
     CDS             42763..43380
                     /locus_tag="VVO18_000221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribulokinase"
                     /protein_id="HEU5585445.1"
                     /translation="MKKKDLVDQLVSEIETGKVRTLGIYGHGASGKSTFAQELYQALD
                     STTVNLLETDPYITSGRHLVVPKDAPNQKVTASLPVAHELESLQRDILALQAGMDVLT
                     IEEPWKASEVLSGAKPILIVEGMSVGFLPKELFEKTICFYTDEETELKRRLARDTTVR
                     NRDASFILASHQMRREQYLRYYKETESKADILVDQSEDKFDVKRT"
     gene            43646..43954
                     /gene="rpsJ"
                     /locus_tag="VVO18_000222"
     CDS             43646..43954
                     /gene="rpsJ"
                     /locus_tag="VVO18_000222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003046044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S10"
                     /protein_id="HEU5585446.1"
                     /translation="MANKKIRIRLKAYKHRTLDTAAAKIVESATRTGAQVAGPIPLPT
                     ERSLYTIIRATHKYKDSREQFEMRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL
                     "
     gene            44171..44797
                     /gene="rplC"
                     /locus_tag="VVO18_000223"
     CDS             44171..44797
                     /gene="rplC"
                     /locus_tag="VVO18_000223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002986659.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L3"
                     /protein_id="HEU5585447.1"
                     /translation="MTKGILGKKVGMTQIFTEAGELIPVTVIEATPNVVLQVKTVETD
                     GYNAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNVEGLEVGAEITVETFAA
                     GDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAG
                     RMGGDRVTIQNLEVVQVVPEKNVILIKGNVPGAKKSLITIKSAVKAGK"
     gene            44822..45445
                     /gene="rplD"
                     /locus_tag="VVO18_000224"
     CDS             44822..45445
                     /gene="rplD"
                     /locus_tag="VVO18_000224"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L4"
                     /protein_id="HEU5585448.1"
                     /translation="MANVTLFDQTGKEAGQVVLSDAVFGIEPNESVVFDVIISQRASL
                     RQGTHAVKNRSAVSGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYGYKLP
                     QKVRRLALKSVYSEKVAENKFVAVDALSFTAPKTAEFAKVLAALSIDSKVLVILEEGN
                     EFAALSARNLPNVKVATATTASVLDIANSDKLLVTQAAISKIEEVLA"
     gene            45445..45741
                     /locus_tag="VVO18_000225"
     CDS             45445..45741
                     /locus_tag="VVO18_000225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L23"
                     /protein_id="HEU5585449.1"
                     /translation="MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKFLIKQAVEA
                     AFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE"
     gene            45759..46592
                     /gene="rplB"
                     /locus_tag="VVO18_000226"
     CDS             45759..46592
                     /gene="rplB"
                     /locus_tag="VVO18_000226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019790357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L2"
                     /protein_id="HEU5585450.1"
                     /translation="MGIRVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVALKSKAGRN
                     NNGRITVRHQGGGHKRFYRLVDFKRNKDNVEAVVKTIEYDPNRSANIALVHYTDGVKA
                     YIIAPKGLEVGQRIVSGPEADIKVGNALPLANIPVGTLIHNIELKPGRGGELVRAAGA
                     SAQVLGSEGKYVLVRLQSGEVRMILGTCRATVGVVGNEQHGLVNLGKAGRSRWKGIRP
                     TVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNE
                     K"
     gene            46696..46977
                     /gene="rpsS"
                     /locus_tag="VVO18_000227"
     CDS             46696..46977
                     /gene="rpsS"
                     /locus_tag="VVO18_000227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000533767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S19"
                     /protein_id="HEU5585451.1"
                     /translation="MGRSLKKGPFVDEHLMKKVEAQANDEKKKVIKTWSRRSTIFPSF
                     IGYTIAVYDGRKHVPVYIQEDMVGHKLGEFAPTRTYKGHAADDKKTRRK"
     gene            46989..47333
                     /gene="rplV"
                     /locus_tag="VVO18_000228"
     CDS             46989..47333
                     /gene="rplV"
                     /locus_tag="VVO18_000228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L22"
                     /protein_id="HEU5585452.1"
                     /translation="MAEITSAKAMARTVRVSPRKSRLVLDNIRGKSVADAIAILTFTP
                     NKAAEIILKVLNSAVANAENNFGLDKANLVVSEAFANEGPTMKRFRPRAKGSASPINK
                     RTAHITVAVAEK"
     gene            47346..47999
                     /gene="rpsC"
                     /locus_tag="VVO18_000229"
     CDS             47346..47999
                     /gene="rpsC"
                     /locus_tag="VVO18_000229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S3"
                     /protein_id="HEU5585453.1"
                     /translation="MGQKVHPIGMRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFVQK
                     ELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAKLNKLTGKQVHINI
                     IEIKQPDLDAHLVGEGIARQLEQRVAFRRAQKQAIQRAMRAGAKGIKTQVSGRLNGAD
                     IARAEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEVLPARKNTKGGK"
     gene            48003..48416
                     /gene="rplP"
                     /locus_tag="VVO18_000230"
     CDS             48003..48416
                     /gene="rplP"
                     /locus_tag="VVO18_000230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003029477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L16"
                     /protein_id="HEU5585454.1"
                     /translation="MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITN
                     RQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKV
                     MFEIAGVSEEIAREALRLASHKLPVKCKFVKREAE"
     gene            48426..48632
                     /locus_tag="VVO18_000231"
     CDS             48426..48632
                     /locus_tag="VVO18_000231"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006739716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L29"
                     /protein_id="HEU5585455.1"
                     /translation="MKLNEVKEFVKELRGLSQEELAKRENELKKELFELRFQAATGQL
                     EQTARLKEVKKQIARIKTVQSEAK"
     gene            48657..48917
                     /gene="rpsQ"
                     /locus_tag="VVO18_000232"
     CDS             48657..48917
                     /gene="rpsQ"
                     /locus_tag="VVO18_000232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S17"
                     /protein_id="HEU5585456.1"
                     /translation="MERNNRKVLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKK
                     YKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEEAVII"
     gene            48943..49311
                     /gene="rplN"
                     /locus_tag="VVO18_000233"
     CDS             48943..49311
                     /gene="rplN"
                     /locus_tag="VVO18_000233"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012727667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L14"
                     /protein_id="HEU5585457.1"
                     /translation="MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVK
                     QATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPV
                     ARELREGGFMKIVSLAPEVL"
     gene            49389..49694
                     /gene="rplX"
                     /locus_tag="VVO18_000234"
     CDS             49389..49694
                     /gene="rplX"
                     /locus_tag="VVO18_000234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011921687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L24"
                     /protein_id="HEU5585458.1"
                     /translation="MFVKKGDKVRVIAGKDKGTEAVVLTALPKVNKVIVEGVNIVKKH
                     QRPTNELPQGGIIEKEAAIHVSNVQVLDKNGVAGRVGYKFVDGKKVRYNKKSGEVLD"
     gene            49718..50260
                     /gene="rplE"
                     /locus_tag="VVO18_000235"
     CDS             49718..50260
                     /gene="rplE"
                     /locus_tag="VVO18_000235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L5"
                     /protein_id="HEU5585459.1"
                     /translation="MANRLKEKYLNEVVPALTEQFNYSSVMAVPKVDKIVLNMGVGEA
                     VSNAKSLEKAAEELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGERMYEFLD
                     KLVSVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDDVDKTRGLDIVIVTT
                     ANTDEESRALLTGLGMPFAK"
     gene            50278..50547
                     /gene="rpsN"
                     /locus_tag="VVO18_000236"
     CDS             50278..50547
                     /gene="rpsN"
                     /locus_tag="VVO18_000236"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006738440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S14"
                     /protein_id="HEU5585460.1"
                     /translation="MAKKSMVAREAKRQKIVDRYAEKRAALKAAGDYEGLSKLPRNAS
                     PTRLHNRCRVTGRPHSVYRKFGLSRIAFRELAHKGQIPGVTKASW"
     gene            50832..51230
                     /gene="rpsH"
                     /locus_tag="VVO18_000237"
     CDS             50832..51230
                     /gene="rpsH"
                     /locus_tag="VVO18_000237"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009754342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S8"
                     /protein_id="HEU5585461.1"
                     /translation="MVMTDPIADFLTRIRNANQAKHEVLEVPASNIKKGIAEILKREG
                     FVKNVEIIEDDKQGVIRVFLKYGPNGEKVITNLKRVSKPGLRVYKKREDLPKVLNGLG
                     IAILSTSEGLLTDKEARQKNVGGEVIAYVW"
     gene            51422..51958
                     /gene="rplF"
                     /locus_tag="VVO18_000238"
     CDS             51422..51958
                     /gene="rplF"
                     /locus_tag="VVO18_000238"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399261.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L6"
                     /protein_id="HEU5585462.1"
                     /translation="MSRIGNKVIVLPAGVELANNDNVVTVKGPKGELTREFSKDIEIR
                     VEGTEVTLHRPNDSKEMKTIHGTTRALLNNMVVGVSEGFKKELEMRGVGYRAQLQGSK
                     LVLAVGKSHPDEVEAPEGITFELPNPTTIVVSGISKEVVGQTAAYVRSLRSPEPYKGK
                     GIRYVGEFVRRKEGKTGK"
     gene            52042..52398
                     /gene="rplR"
                     /locus_tag="VVO18_000239"
     CDS             52042..52398
                     /gene="rplR"
                     /locus_tag="VVO18_000239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L18"
                     /protein_id="HEU5585463.1"
                     /translation="MISKPDKNKLRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQV
                     IDDVAGVTLASASTLDKEVSKGTKTEQAVAVGKLVAERANAKGISEVVFDRGGYLYHG
                     RVKALADAARENGLKF"
     gene            52416..52910
                     /gene="rpsE"
                     /locus_tag="VVO18_000240"
     CDS             52416..52910
                     /gene="rpsE"
                     /locus_tag="VVO18_000240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S5"
                     /protein_id="HEU5585464.1"
                     /translation="MAFKDNAVELEERVVAVNRVTKVVKGGRRLRFAALVVVGDHNGR
                     VGFGTGKAQEVPEAIRKAVDDAKKNLIEVPMVGTTIPHEVLSEFGGAKVLLKPAVEGS
                     GVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEIAALRGISV
                     SDLA"
     gene            52882..53106
                     /gene="rpmD"
                     /locus_tag="VVO18_000241"
     CDS             52882..53106
                     /gene="rpmD"
                     /locus_tag="VVO18_000241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012386624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L30"
                     /protein_id="HEU5585465.1"
                     /translation="MVFQFLIWHKKGDKMAQIKITLTKSPIGRIPSQRKTVVALGLGK
                     LNSSVIKEDNAAIRGMITAVSHLVTVEEVN"
     gene            53251..53691
                     /gene="rplO"
                     /locus_tag="VVO18_000242"
     CDS             53251..53691
                     /gene="rplO"
                     /locus_tag="VVO18_000242"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004225266.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L15"
                     /protein_id="HEU5585466.1"
                     /translation="MKLHELKPAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGG
                     GVRLGFEGGQTPLFRRLPKRGFTNINAKEYAIVNLDQLNVFEDGAEVTPVVLIEAGIV
                     KAEKSGIKILGNGELTKKLTVKAAKFSKSAEEAITAKGGSVEVI"
     gene            53704..55014
                     /gene="secY"
                     /locus_tag="VVO18_000243"
     CDS             53704..55014
                     /gene="secY"
                     /locus_tag="VVO18_000243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecY"
                     /protein_id="HEU5585467.1"
                     /translation="MFFKLLREALKVKQVRSKILFTIFIVLVFRIGTSITVPGVNANS
                     LNALSGLSFLNMLSLVSGNALKNFSIFALGVSPYITASIVVQLLQMDILPKFVEWGKQ
                     GEVGRRKLNQATRYIALVLAFVQSIGITAGFNTLAGAQLIKTALTPQVFLTIGIILTA
                     GSMIVTWLGEQITDKGYGNGVSMIIFAGIVSSIPEMIQGIYVDYFVNVPSSRITSSII
                     FVIILIITVLLIIYFTTYVQQAEYKIPIQYTKVAQGAPSSSYLPLKVNPAGVIPVIFA
                     SSITAAPAAILQFLSATGHDWAWVRVAQEMLATTSPTGIAMYALLIILFTFFYTFVQI
                     NPEKAAESLQKSGAYIHGVRPGKGTEEYMSKLLRRLATVGSLFLGVISILPIAAKDVF
                     GLSDVVAFGGTSLLIIISTGIEGIKQLEGYLLKRKYVGFMDRTE"
     gene            55165..55803
                     /locus_tag="VVO18_000244"
     CDS             55165..55803
                     /locus_tag="VVO18_000244"
                     /EC_number="2.7.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001050429.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylate kinase"
                     /protein_id="HEU5585468.1"
                     /translation="MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTE
                     MGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLA
                     ELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
                     PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK"
     gene            55920..56138
                     /gene="infA"
                     /locus_tag="VVO18_000245"
     CDS             55920..56138
                     /gene="infA"
                     /locus_tag="VVO18_000245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-1"
                     /protein_id="HEU5585469.1"
                     /translation="MAKDDVIEVEGKVVDTMPNAMFTVELENGHQILATVSGKIRKNY
                     IRILAGDRVTVEMSPYDLTRGRITYRFK"
     gene            56163..56279
                     /gene="rpmJ"
                     /locus_tag="VVO18_000246"
     CDS             56163..56279
                     /gene="rpmJ"
                     /locus_tag="VVO18_000246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013773089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L36"
                     /protein_id="HEU5585470.1"
                     /translation="MKVRPSVKPICEYCKVIRRNGRVMVICPANPKHKQRQG"
     gene            56297..56662
                     /gene="rpsM"
                     /locus_tag="VVO18_000247"
     CDS             56297..56662
                     /gene="rpsM"
                     /locus_tag="VVO18_000247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S13"
                     /protein_id="HEU5585471.1"
                     /translation="MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVR
                     VRDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNT
                     KNNARTRKGKAVAIAGKKK"
     gene            56680..57063
                     /gene="rpsK"
                     /locus_tag="VVO18_000248"
     CDS             56680..57063
                     /gene="rpsK"
                     /locus_tag="VVO18_000248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003130556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S11"
                     /protein_id="HEU5585472.1"
                     /translation="MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSS
                     AGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAG
                     LEVTAIRDVTPVPHNGARPPKRRRV"
     gene            57106..58041
                     /locus_tag="VVO18_000249"
     CDS             57106..58041
                     /locus_tag="VVO18_000249"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit alpha"
                     /protein_id="HEU5585473.1"
                     /translation="MIEFEKPNITKIDENKDYGKFVIEPLERGYGTTLGNSLRRVLLA
                     SLPGAAVTSINIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKIIELDVEGP
                     AEVTAGDILTDSDIEIVNPDHYLFTIGEGSSLKATMTVNSGRGYVPADENKKDNAPVG
                     TLAVDSIYTPVTKVNYQVEPARVGSNDGFDKLTLEILTNGTIIPEDALGLSARILTEH
                     LDLFTNLTEIAKSTEVMKEADTESDDRILDRTIEELDLSVRSYNCLKRAGINTVHDLT
                     EKSEAEMMKVRNLGRKSLEEVKLKLIDLGLGLKDK"
     gene            58053..58439
                     /gene="rplQ"
                     /locus_tag="VVO18_000250"
     CDS             58053..58439
                     /gene="rplQ"
                     /locus_tag="VVO18_000250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002887523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L17"
                     /protein_id="HEU5585474.1"
                     /translation="MAYRKLGRTSSQRKAMLRDLTTDLLINESIVTTEARAKEIRKTV
                     EKMITLGKRGDLHARRQAAAFVRNEIASENYDEATDKYTSTTALQKLFSEIAPRYAER
                     NGGYTRILKTEPRRGDAAPMAIIELV"
     gene            58704..58970
                     /locus_tag="VVO18_000251"
     CDS             58704..58970
                     /locus_tag="VVO18_000251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002905356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACT domain-containing protein"
                     /protein_id="HEU5585475.1"
                     /translation="MKAIITVVGKDKSGIVAGVSGKIAELGLNIDDISQTVLDEYFTM
                     MAVVSSDEKQDFTYLRNEFEAFGQTLNVKINIQSAAIFEAMYNI"
     gene            58980..60317
                     /locus_tag="VVO18_000252"
     CDS             58980..60317
                     /locus_tag="VVO18_000252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PFL family protein"
                     /protein_id="HEU5585476.1"
                     /translation="MDIRQVTETIAMIEEQNFDIRTITMGISLLDCIDPNINRAAEKI
                     YQKITTKAANLVAVGDEIAAELGIPIVNKRVSVTPISLIGAATDATDYVVLAKALDKA
                     AKEIGVDFIGGFSALVQKGYQKGDEILINSIPRALAETDKVCSSVNIGSTKSGINMTA
                     VADMGRIIKETANLSDMGVAKLVVFANAVEDNPFMAGAFHGVGEADVIINVGVSGPGV
                     VKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGQMASERLGVEFGIVDLSLAPTPA
                     VGDSVARVLEEMGLETVGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDE
                     GMIAAVQNGSLNLEKLEAMTAICSVGLDMIAIPEDTPAETIAAMIADEAAIGVINMKT
                     TAVRIIPKGREGDMIEFGGLLGTAPVMKVNGASSVDFISRGGQIPAPIHSFKN"
     gene            60561..61253
                     /locus_tag="VVO18_000253"
     CDS             60561..61253
                     /locus_tag="VVO18_000253"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU5585477.1"
                     /translation="MVKVRLYLVRHGKTMFNTIGRAQGWSDTPLTAEGERGIQELGIG
                     LRESDLQFERAYSSDSGRTIQTMGIILEELGLQGKIPYRMDKRIREWCFGSFDGAYDG
                     DLFMGIIPRIFNVDHVHQLSYAELAEGLVEVDTAGWAEGWEKLSGRIKEGFEMIAKEM
                     EDQGGGNALVVSHGMTIGTIVYLINGMHPHGLDNGSVTILEYEDGQFRVEVVGDRSYR
                     ELGREKMEEGSI"
     gene            complement(61356..63001)
                     /locus_tag="VVO18_000254"
                     /pseudo
     CDS             complement(61356..63001)
                     /locus_tag="VVO18_000254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520796.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
     gene            complement(62991..64082)
                     /locus_tag="VVO18_000255"
     CDS             complement(62991..64082)
                     /locus_tag="VVO18_000255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001289361.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585478.1"
                     /translation="MSEIEIINAKKIYHDVPVIENLNITIPKGSLFTLLGASGCGKTT
                     LLRMIAGFNSIKDGEFYFDDTKINNMEPSKRNIGLVFQNYAIFPHLTVRDNVAFGLMQ
                     KKVPKEELIQQTNKYLGLMQIAQYADRKPDKLSGGQQQRVTLACALAVNPSVLLMDEP
                     LSNLEAKLRLDMRQAIREIQHEVGITTVYVTHDQEEAMAISDQIAVMKDGVIQQIGRP
                     KELYHKPANEFVATFIGRTNIIPANLEKRSDGAYIVFSDGYALRMLALDQVEEQAIHV
                     SIRPEEFIKDESGDIEGTISDSVYLGLNTEYFIETGFASKIQVSEESTFEEELQKGNR
                     IRLRINTQKLNIFSADGSQNLIKGVNHGT"
     gene            complement(64095..65216)
                     /locus_tag="VVO18_000256"
                     /pseudo
     CDS             complement(64095..65216)
                     /locus_tag="VVO18_000256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931989.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
BASE COUNT        20148 a        12134 c        14059 g        18979 t
ORIGIN      
        1 catactgggt taaatgacct ccatcgaaag atagttggta aaaagacttg ttttggaagt
       61 gatgatttgg taaactgttc atgtgagttt cctttctttt tgtgtttttt tctacactta
      121 taccataaag gggaaactct tttttgtcta gtaaaaaaca cccattgggt gaaaaaagaa
      181 accatccagg atctaagcta aggcaaggat tctggatggt ttttagatta ggggtgaata
      241 attggggtat aaagttctta taagaggtgg ttgaagttgt tcaactgttt tttgagtata
      301 aacagtcttt aagaacgtaa aaaagcataa gttcaggtct tcaaaacctt gttcttatgc
      361 tttttatcat agaaatattt gctgaatttt ctcttgaaat gaaaccttat cttcatctcg
      421 cgcttgtccc ttaccctgct tttccgattg cgagtgcgta gataaagaag atggcgaagc
      481 caaagaggaa aatcaatccc gcaatggcaa ggtgtttgag ccaagaagga agatttttgt
      541 tttcacgcgt taccaaggcg taattcaaaa gagcaaagaa aggtgttgtc aggaaagagc
      601 caatcatggc aaagcggagc atggttgaaa cctgaccagc gaagaacttg ataatgacga
      661 taccgatgat agcagtgatg gtcatccaga tgttcaaaga tttacgattg tcttcttttt
      721 gactgattag cagtcggaga gattcctgat taacgcgaga atagccatcg ataacagtta
      781 taactgttcc aaagatacag aggaaggcaa taaaggtaat caagtaacgg gaccattcgc
      841 caagaacaga ggcatacatg cccacgaatt gagagatgta tttggctgaa gcagcttcaa
      901 ccgcctgccc tgtaggatac tgaatcagtg ctcccagtgc cacaaagaag acggctagga
      961 tagctgttcc aatataacca gtgttaaagt caaacagagc gtcttctgtg ttaaagttga
     1021 cggtctttct cttttcagct gaccaaagtg aattgatggc tgaaatttca ataggagccg
     1081 gcatccatcc taggagggag acgatgaagg gcagagctgc catttgccaa ggtgtcttct
     1141 cgacaaaatc agaactgtat tctggatgct tgaccgctgc tatgataact gccagaacag
     1201 tcgcaatagt taaggcagac ataatccatt tgaccatgcc gtctaaaagt ttgtagcctc
     1261 caaagagtag catagcccaa atgattgcaa cgagaatgag ggaccactga gtaatgctaa
     1321 gtccaatcat tgggaaggca ctggcgatga tagctgagca cagaatggca acaccagccg
     1381 tgttgaccat agccgaaaag acattgagga taaagaaaat ccagagatag agttttcctt
     1441 tttcggcata accttcaacc aaagtctttc cagtatcagc tgtgtattca gcaccaaaac
     1501 ggaaaaatgg atatttaaag acattggcta agatgaccaa gagaagtaga gaccaaccgt
     1561 aagaaccgcc agcttgagtt gaggatacaa tgtgggaacc tccaacagcg gcagttgcca
     1621 ttaggattcc aggtcccatt gcttttagct tgcttgccca ggttgattga tttaaggaaa
     1681 tagcttgcga catgataaat actccttttt gaattttcag aataatctgt atatgcaatc
     1741 tatattctac aaaaaatttt ggaaaaatgc aagaatattt tgaaaaaaga tagaaaattt
     1801 acaaagaaaa tctgaaataa ctgttatgat atagcagatt gaaactagaa tagtacactt
     1861 ttgcttctaa aacattgtta gaaatcgatt tgactgtcct gatcgattta tcctgttctt
     1921 atttcatttc actatagtaa ggtgcagcag gataaagaaa aaccgagaag tttctttctc
     1981 ggatttgctt attatgaggt tcctattttc tatgctccaa gagttgattg atgtgatcta
     2041 cttttttagc ctctctttta tagagaatag cccagatgat gagatagaca atcgcaaact
     2101 cgataatgag ctggaggtag aaaatccagt ggaaagggaa ccaaccagca agagttgcta
     2161 gtgggacaaa gccagccagc ataaggaaga aatgagtcag agtggcacga agcatgctcc
     2221 agtcacggct aaataagcgg ttgccaaagt tgaagagcat accgatggtt gcccagataa
     2281 gtgtgcagta gagcaagacc agggcaccgt gaacctgatg ctgatccatc acttggccga
     2341 tgagagagta gggatttagt ggtgcgtagg tatttggtgc ataaatgagt gaaaagagga
     2401 tagagaggat gaggccgata agaacaccgg cagctgcatc gtgaaatact tgttttttca
     2461 tagttctaat ttctccttga tggtttttag ataacggcgt gaagagtagg tgaagctttc
     2521 gtttttcaag aaaatttcta tcagaccgtt tggcgtgagc ttgaggtgag agatggaatc
     2581 gatattgatg atttctgatt gggaaatttg gataaaattg gttggcaaga gtttaagaac
     2641 ctgatagagt cgcaaatcaa tgctgtaggt ctgactcgcg gtttctgcta gaaccttccg
     2701 attctcgata tagaagcgct gaatcttgcc aatctcaact agatagacct gatcatcgat
     2761 tttccctttg attttttctc tttggtccag attttctgcg aactcgatga ctttctgaac
     2821 tttatctgtc ggctgaggtg cttggacaat cagcttttcc tcctcgtaag tctcactaat
     2881 ctgtaattct actttcataa atttctctcc ttgtttttca tacaaaatta atctcacttc
     2941 ttgtacacct ttattaatac tcttcaaaaa tctcttcaaa ccacgtcagc gtcgtcttgc
     3001 cgtaggatag ttgttgactt tgtcagtttt atctacaacc tcaaaacagt gttttgagct
     3061 gtctgcgcct agctttctag tttgctcttt gatttttatt gagtatacca ctattttact
     3121 ccctctggca aggtactttg tctatgtgga gggattgggc tcctatgtgg tggagctttt
     3181 ctgttctttc tgaaatatgg tataatagca ctaatcaatt tctaggaaaa tagatacaga
     3241 aaggggctga aagatgtctc atattattga attgccagag atgctggcaa accaaatcgc
     3301 ggctggagag gtcattgaac gtcctgccag tgtggtcaaa gagttggtag aaaatgccat
     3361 tgacgcgggc tctagtcaga ttatcattga gattgaggaa gctggtctca agaaggttca
     3421 aatcacggat aacggtcatg gaattgccca cgatgaggtg gagttggccc tgcgtcgcca
     3481 tgcgaccagt aagataaaaa atcaagcaga tctctttcgg attcggacgc ttggttttcg
     3541 tggtgaagcc ttgccttcta ttgcgtctgt tagtgtcttg actctgttaa cggcggtgga
     3601 tggtgctagt catggaacca agttagtcgc gcgcgggggt gaagttgagg aagtcatccc
     3661 agcgactagt cctgtgggaa ccaaggtttg tgtggaggat ctctttttca acacgcctgc
     3721 ccgtctcaag tatatgaaga gccagcaagc ggagttgtct catatcattg atattgtcaa
     3781 ccgtctgggc ttggcccatc ctgagatttc ttttagcttg attagtgatg gcaaggaaat
     3841 gacgcggaca gcagggactg gtcaattgcg ccaagcaatc gcagggattt acggtttgat
     3901 cagtgccaag aagatgattg aaattgagaa ctctgaccta gatttcgaaa tttcaggttt
     3961 tgtgtccttg cctgagttga ctcgggctaa ccgcaattat atcagcctct tcatcaatgg
     4021 tcgttatatc aagaacttcc tgctcaatcg tgctattttg gatggtttcg gaagcaagct
     4081 tatggttgga cgttttccac tggctgtcat tcacatccat atcgaccctt atctagcgga
     4141 tgtcaatgtg catccaacta agcaagaggt gcggatttcc aaggaaaaag aactgatgac
     4201 cctggtttca gaagctattg caaatagtct caaggaacaa accttgattc cagatgcctt
     4261 ggaaaatctt gccaaatcga ccgtgcgcaa tcgtgagaag gtggatcaaa ctattctccc
     4321 actcaaagaa aatacgctct actatgagaa aactgagccg tcaagaccta gtcaaactga
     4381 agtagctgat tatcaggtag aattgactga tgaagggcag gatttgaccc tgtttgccaa
     4441 ggaaaccttg gaccgattga ccaagccagc aaaactgcat tttgcagaga gaaagcctgc
     4501 taactacgac cagctagacc atccagagtt agatcttgct agcatcgata aggcttatga
     4561 caaactggag cgagaagaag catccagctt cccagagttg gagtttttcg gacaaatgca
     4621 cgggacttat ctctttgccc aagggcgaga tggactttac atcatagatc agcacgctgc
     4681 tcaggaacgg gtcaagtacg aggagtaccg tgaaagcatt ggcaatgttg accagagcca
     4741 gcagcaactc ctagtgccct atatctttga atttcctgcg gatgatgccc tgcgtctcaa
     4801 ggaaagaatg cctctcttag aggaagtggg cgtctttcta gcagagtacg gagaaaatca
     4861 atttattcta cgtgaacatc ctatttggat ggcagaagaa gagattgaat caggcatcta
     4921 tgagatgtgc gacatgctcc ttttgaccaa ggaagtttct atcaagaaat accgagcaga
     4981 gctggctatc atgatgtctt gcaagcgatc tatcaaggcc aatcatcgta ttgatgatca
     5041 ttcagctaga caactcctct atcagctttc tcaatgtgac aatccctata actgtcctca
     5101 cggacgtcct gttttggtgc attttaccaa gtcggatatg gaaaagatgt tccgacgtat
     5161 tcaggaaaat cacaccagtc tccgtgagtt ggggaaatat taaaagtata aaaaagtctg
     5221 ggaaaaattt tcaaaatcag aaaaacgcat aaaatcaggt gttcaaaaac cttgatttta
     5281 tgcgttttat catagaaata tttacttcat tttttcctaa ttcttttcga aactcttttt
     5341 aaacgacgtc agttttatca gtaatctcaa aacagtgttt tgagctaatt ttgccagttt
     5401 tgtctgtaac atcgaagttg tgttttacca ctctgcgact ggtttcctag tttgctctat
     5461 gattttcaca gagtattaaa ttgcgatttt gccaagtttc tttattcgtc taaaagtaga
     5521 gtctgttcta tgcgtctaat gtacgaatta ggttgaccat ttcaatagct ccttgtgcac
     5581 actcagaacc cttatttcct gctttagtac cagctcgttc tatggcttgt tcaattgtat
     5641 ctgtcgttag cacaccaaac ataacaggaa tttcgctatt taaactgatt tgggcgattc
     5701 ccttagatac ctcgctacat acataatcat aatgacttgt attccctcta atgacagctc
     5761 ccaagcagat aattgcatca tattttttac tttttgccat ttttgatgca atcagtggta
     5821 tttcaaaagc tcctggaacc caggctacct ctatatcttt ctcgtttaca ttctctcttt
     5881 tgagattatc tagtgctcca gataataatt ttgaagttat aaattcatta aatctcgcta
     5941 caacaatacc tattttaata ttgtttgcta ctaaattacc ttcataagtg ttcatttatt
     6001 tttcctccat atttaaaatg tgacccattc gatttttctt tgtttctaaa taaaaactat
     6061 cgtaaggatt ggcttctatt tcgattgata ttctactgga aatggtaatt ccatattttt
     6121 ctaactgttc aaccttgtca ggattatttg tcagtaaatg aagtgactga agtcccagat
     6181 ctttaagcat ttgtgctcca atatgatatt ctcttaaatc accttcaaag cctaatgcaa
     6241 gattggcatc aagcgtatcc atgccttgat cttgtaaatg ataggctttt aatttattga
     6301 taagtccaat tcctcgtccc tcctgtcgca agtaaagtaa gacacccgaa ccattctcaa
     6361 caattatttt catagcttta tcgaattgct gtccacaatc gcaacgtaaa gagcctaaaa
     6421 catctcctgt taaacattcg gagtggaccc gacataatac attggcttca tcctctatgt
     6481 ttcccataat aagagcaaga tgatgttccc catttagttt atctatatag ctaattgctt
     6541 tgaaattacc gtatctagta ggcatattga cagttgaaac tcgttctacc agctgatcat
     6601 atgcttttct atattcttgt aattctttga tggtaattag tggaatgttg tgtttcttcg
     6661 agaactgaat taaatcatct attctcatca ttttgccatc atgattcatt atttcacaac
     6721 ataggccaca ctcttttagt ccagctaatt ttaataaatc aacagttgct tctgtgtgtc
     6781 catttctttc tagaacacca cctttttttg caattaaagg aaacatgtgt cctggcctgc
     6841 gaaaatcaga gggtgttata tcttcagcta cacacatacg tgcggtcagt cctctctcct
     6901 cggcagaaat acctgtggtc gtttctttat aatcaattga aactgtaaaa gcagtcttat
     6961 gattatctgt attgttttca accataggtg aaagcattaa ttgattagct aaactttcgc
     7021 tcataggcat acaaattaat cctttggcat aagtagccat aaaattaaca ttttctgttg
     7081 tagctgcttg tgcagaacaa attaagtctc cttcattttc tctatccttg tcgtctataa
     7141 caagaacaag tcgtcccttc tgcaatgctt ctaatgcttc ttgtattttt cgatattcca
     7201 ttgactgatt atcctttctg ctaaaatcca ttttgatata atagttcctt cgatatttct
     7261 gattttggag agttatccat cagtttttgc acatatttac ctaagatatc attttcaaga
     7321 tttactgtac tcccgacttg tttactctta agaatggttt gtttcaaggt atgagggata
     7381 acagatactg aaaagtttac tttggagact ttagcgacag tcagactaat gccgtcaatt
     7441 gtaatagatc ctttttcaac tattaaatct aaaatttctt tttgtgtgtt gatttgatac
     7501 catacagcat tatcatcttt ttttattgac gagatttttc ctgtaccatc aatgtgtcct
     7561 gtaacgacgt gacccccaag tcgaccgttg acagataagg ctctttctag attcacctca
     7621 cttccatgtt ttaatagagt aagagctgtt cgactccatg tttcattcat tacatcaact
     7681 gtaaaggatt gatgattgaa atgagtaact gtaagacaga taccatttac tgctatacta
     7741 tcgcctaaat ggatatccgt taatattttt gaggctttaa ttgatagttt acaattacga
     7801 gagtctttct gtattctttc aacttttccg atttcttcaa ttattcctgt gaacatggat
     7861 aaatcacttc actttctatg agatagtcat ttcctatttg agaaaaagca taaggtttca
     7921 atctaatagc gtcatttggc aaagaaatgc cttcacctcc gacaggaaac ttggcactgc
     7981 ctccaaaaat ttttggtgca atatatattt tcagctcatc aacaatttgt tgttccaaag
     8041 cactccaatt cattagactg cccccttcta gaactaggct atcaatctgc atgtttccta
     8101 gatgttgcat taaactcgat aagtctatat gattgccttt tttctttatg gaaagtattt
     8161 cacagccatg attttgatat agcttcattt tatttttgtc ttcagaggaa gtggcaatgt
     8221 aagttttaat atcatttgct gtttttacga ttttagaggt aagaggagtt cgtaaatgtg
     8281 tatcgcatat gatacggata ggatttttcc cttcctccaa tctacatgtc agcaaaggat
     8341 cgtcttgaat aacagtattg actcccacca taattgcact aacatggtgt cgtaactgat
     8401 gcacatgctt tcttgcctct tcttcagtaa tccatttgga ttgatttgtt ttagtggcta
     8461 tttttccatc aattgtcatt gcatatttca taaaaacata gggtacatgc tgggtaatat
     8521 actttctaaa actttttatt aagttaagac actcattttc taaaattcca acagtaactt
     8581 gaagattatt ttcctcaagt atctttactc cttttccaga tacaatagga ttacagtcta
     8641 ggcttccaat gactactctt gtaataccac tatcgattat agcatctata caaggaggtg
     8701 ttttcccgaa gtgacaacag ggttcaagtg ttacataaag cgtcgctccg acaggggatt
     8761 ctctacagtt tttaagagca tttctctcag catgtgagcc accaaaaaac tcatgataac
     8821 cttgtccgat gatgtgatta tcttttacaa taactgcgcc gaccatagga ttgggattga
     8881 cgtaaccagc ccctttttgt gccagtttta ttgctaattt catatatttt gaatcgctca
     8941 tctcactacc tccaaaaaaa tataccttga ataggagact actcaaggca tacaaaagaa
     9001 aacttatgcg attaacaaaa atgctctgaa atgacaagta atcatttcag agcacgcaaa
     9061 aagcacaaat atacttttat cttctttcat ccagactata ctgtcggctt tggaatttca
     9121 ccaaatcatg cctttcggct cgtgggctat accaccggta gggaattgca ccctgccctg
     9181 aagatagtta ttcaattaca gatgattata gtacttaatt ttgaatatgt caacagataa
     9241 ataccgattg tttttgatat actgtatttg tgataatcga ttctcgctcc tcggataaag
     9301 aaaatatgat atactagata aacgaaataa gagagaagga acactatgta cgcatattta
     9361 aaaggaatca ttaccaaaat tactgccaaa tacattgttc ttgaaaccaa tggtattggt
     9421 tatatcctgc atgtggccaa tccttatgcc tattcaggtc aggttaatca ggaggatcag
     9481 atttatgtgc atcaggttgt gcgtgaggac gcccatttgc tttatggatt tcgctcagag
     9541 gatgagaaaa agctctttct tagtctgatt tcggtctctg ggattggtcc tgtatcagct
     9601 cttgctatta tcgctgctga tgacaatgct ggcttggttc aagccattga aaccaagaac
     9661 atcacctact tgaccaagtt ccctaaaatt ggcaagaaaa cagcccagca gatggtgctg
     9721 gacttggaag gcaaggtagt agttgcagga gatgaccttc ctgccaagat cgcagtgcaa
     9781 gcaagtgctg aaaaccaaga attggaagaa gctatggaag ccatgttggc tctgggctac
     9841 aaggcaacag agctcaagaa aatcaagaaa ttctttgaag gaacgacaga tacagctgag
     9901 aactatatca agtcggccct taaaatgttg gtcaaatagg agcagagaat gacaaaacgt
     9961 tgttcgtggg tcaagatgac caacccactc tacatcgcct atcatgatga ggagtggggc
    10021 cagcccctcc atgatgacca agcgttgttt gagttgttgt gtatggaaac ctatcaggca
    10081 ggcctgtctt gggaaacggt actcaacaaa cgccaagctt tccgagaagc ctttcatagc
    10141 tatcaaattc actcagtcgc agagatgact gacactgaat tggaagccat gctggagaat
    10201 ccagctatca ttcgaaatag agccaagatt tttgctacac gcgctaacgc ccaagccttt
    10261 ctacagttac aggcagagta cggctctttt gatgcctatc tttggtcttt tgttgagggg
    10321 aaaactgtcg ttaacgatgt tcctgattat cgccaagccc cagctaaaac acccttatct
    10381 gagaaattag ccaaagatct caaaaaacga gacttcaagt tcacaggccc agtcgccgta
    10441 ttgtcttttc tacaggctgc agggctagtt gatgaccacg agaatgattg tgagtggaaa
    10501 ggtcttaaat gatgtctaac aaaaataagg gaattctgat ttttgcgatt ctctatacag
    10561 tcctctttgt gtttgatggc gttaaattgc tggcttcttt aatgccatct gccattgcaa
    10621 attatcttgt ttatgtagtt ttagctttat atggctcctt cttgttcaag gatagattga
    10681 tccaacaatg gaaggagatt agaaagacta aaagaaaatt cttctttgga gtcttaacag
    10741 gatggctctt tctcattctg atgactgttg tctttgaatt tgtatcagag atgttgaagc
    10801 agtttgtggg actagatgga caaggtctaa atcagtctaa tattcaaagt acctttcaag
    10861 aacaaccact actgatagct gtttttgctt gtgtcattgg acctctggta gaagaattat
    10921 ttttccgtca ggtcttattg cattacttgc aggaacggtt gtcaggttta ctaagcatta
    10981 ttctggtagg acttgttttt gctctgactc atatgcacag tttggctcta tcagagtgga
    11041 ttggtgcagt tggttactta ggtggaggcc ttgccttttc tattatttat gtgaaagaaa
    11101 aagagaatat ctactatccc ctacttgttc acatgttaag caacagcctc tccttaatca
    11161 ttttagctat cagtatagta aaatgaaatg agaacaggac aaatcgattt ctaacaatgt
    11221 tttagaagta gaggtgtact attctagttt caatatactg taatatgtga tgaaaatgcc
    11281 agtaatgata ccgagaaaaa agctgagaaa cttttcccag ctttatttgt tatagtcaaa
    11341 gagaatgact tgttcctgtg catctacatg agcatggacc ccaaagggta caattgctct
    11401 tggagttgcg tggccgacat tcagattata gacaatcggg atattgctgt caatgatatc
    11461 caatagtgcc tctttatagt cgtcatggaa agtttcatcc ataggttttc cgaccaagag
    11521 tccattgatg accgcgaata tgccagtgtc ctttaaagtt agcaacatct ttttgaagtc
    11581 ttctggctta ggcttttctt cgcttgtttc gagcaagagg attttccctt cccagtctga
    11641 caagtcaggg aaaagtttgt atttttggca gagttccgtg ctatctgcgt atcgagagtt
    11701 gtcaaagata tcgtagaggg attcgaggca accaccgagg attttcccct cgaactgagc
    11761 acttccttgc aacaagtcaa aacctgtatt tgtatgactg acacgaggtg ttcccagggc
    11821 cgtgggacta aaatcagttc gttcctcata ccaaacgtca ctagggcgga tttctgaaat
    11881 tcttcccgtc tcaatcaatt ctttaaagta gtgaaggcta taggctagca tttctttgtc
    11941 taattcacaa atgtctgcta aaaaggattg accataaaaa gtcttgattc ctaatttatg
    12001 caacatgagg tggttcatgg ttgtatccga gaagccaaga aaaatttttt gtttgataac
    12061 cttttggagt tggtcatttt caaaaagata aggtagcaag cgataggtat cgtctccacc
    12121 gatggcacat aggatcatgt cgatgctatc atcagaaaag gcatgaatca aatcctctgc
    12181 acgagcttca ggatggtcct tgataaagtc taatcctttt aacgaatggg gcaaaaagat
    12241 gggattgagt cccagatcct tgagacgttg gatacccaag tccacttcgt gtttgacaaa
    12301 atcctctccg ataatgccac tagataaact aacaatacca atagtagaaa ccatatctca
    12361 tcctcctaga aatagattga gcctatttta tcacaaaata taagagaaag ctatgtggga
    12421 tttcagaaga atacttttaa tactcttcga aaatctcttc aaaccacgtc agttttatct
    12481 gcaacttcaa agctgtgctt tgagcaacct gcagctagct tcctagtttg ctctttgatt
    12541 ttcattgagt acaactcaaa aaagtaagtg aaaaagcaac cgcacctgca gttgctttta
    12601 tcgttttctt attcttgata gcgtgttggt cctgcacttg cactacggat attcaagcgt
    12661 ttcttgagat agaagcgaag ggctaggagg gctgctccaa taatagctag tggcaatgga
    12721 tccagtactg ggttaaggct agctggtagg aagcttgttg caaagaagac aagcaaccaa
    12781 aggaacatag aagctaggat aactagtaca gatttccaga aaggtggacg ttgactgcga
    12841 tccatatctg gtccatagta ttggtaaaca aagtagtaca tcaagtagaa ggcaaatcca
    12901 ccaaccagtc caactaatag aagagtaatc aatccatagc cgaaagcttg atctgccgca
    12961 aagaaggttg tgagggcgct gacaagggca aagaggctag tgatgaaaag agctgagtcc
    13021 ataatcatca gttttggatc atcattttct tttggatgct ctttttcgta ctgctctttg
    13081 acagtgaagc tatgagccca atgagttggt gcgccgtata gggaacgggc agttgtacct
    13141 ttagattgct cctcaaggat ttggggaatg acttcctcaa aaatagtctg gatttcagcg
    13201 tctgttttcc catctttgat gaattgttgg gtagcaatgt ggacaaactc ttggtttttc
    13261 ttagttaatt tttgtagatc aatttgagac ataggaactc ctcttagaac cattttttat
    13321 ggatgagata gagagtgagc gagacactca tagcaaaggc gataaagacg attaaccaga
    13381 aggcatttgg ctctccgttt aggggaattt cattatcctt aaagttcatc ccgtaggcag
    13441 aaaagaccat ggttgggatg gacatgacga tggtcacaag ggccaaggtt ttcatgatgt
    13501 tgttctggtt gttagaaatg atagaggcaa aggtctctgt catagaatgc aagacgtttc
    13561 cataaatatc tgccatctcg atggcctgtt gggtttcaat cagggtgtct tcaagcaggt
    13621 cttcgtcctc aaggtatttc ttgatattgc tggttgaact ggtcaatttc ttaatcacgc
    13681 gctcatttgt tttgagggag gccttgaaat agacgatagt tttttccaat tccatgagct
    13741 caatcaattc ttcattacga gttgattgat gcagttgact ttcgatttgt tcactcttgc
    13801 ggtcgattga acgaagggct gttaggtaaa gctctgcatt gcgataaaga atttgaaaga
    13861 taaaacgtga acgcatgaag gtatagaaat tacgcaatcg acggttgata aagacatcaa
    13921 ggacaggtag tggttccaaa cacgtagtga taatggtttc ctcagtgatg ataataccaa
    13981 gcgggatggt tacgtagtag gtgcggttat ttctttcctc cgtgaccggc acgtctacga
    14041 taatcagggt atactcgtct tcaatggtaa tacgagacat ttcttccgca tcgagcggtg
    14101 ctcgaaggtc ggcaatatca atatcgaagg tgttggcgat ttcgagtgat tcattttgag
    14161 tcggattgac gagattgatc caagtacccg gttcaagcgt atcgatctct ttaaattcag
    14221 ttgttgtaga gagaaaaact tgtttcatat cccttatcct ttctcatttt tcagattttt
    14281 tcacactgta ctattatact acaaaatcgg cttttttcaa ataaaatctt acaaagacac
    14341 cgttgttatt ggatttttac tttgtcttga aatgttgatt tttaaatttg ctcccctttt
    14401 tgctccccct atagtgcttt tagtgcagtt tcgtagaatg atactgcttt ttttgcgttc
    14461 tcttttgaga ggtgactata tatatccatg gtcattgata aagtggaatg acctaggcgg
    14521 tactggagtt ccttgtatgg tattccagag ttaagcaaga gactagcgtg agtgtgacgg
    14581 aatccgtgaa atccaatgtt aggaacatca gcacgcttaa aatgtgtttg caatcttctt
    14641 ttaagtcttg aactgctagg atactcatga atgaaatcag aaaataccac gcgttcacgt
    14701 tgccctatct tccaggcctc tttagtttgg cgtagtttgt actgcttcag catgctaaca
    14761 gtcgcttgat ctatatctat atcccgataa ctagccttag actttgggct attgatttct
    14821 atatcccgat ttagtgtttt ggtaatatgc acaacggcat tatctaagtc aatatcagac
    14881 caggaaagag ctaaagcttc attgatacgg caaccagtag ccaataggaa cttatagagt
    14941 gttgtctcat agtagtaacg atatctatga gtatctaaat tatcgagata accaagaaat
    15001 ttttttagtt cttgattttc aaagtgcttt acttttttcc gctttgcttt ctgagtgtta
    15061 cgaggtaaaa caacatcacg cgcaggattg gacggtatag cctgcatggt tacgccatac
    15121 tgtaagatac gtttgtttaa agcgtgtatc ttgtcataat gtagaaaagc cgctttttcc
    15181 cctctattag tcttgtcagc aagttcgttg ataattgact ggataagtgg agtagtgagc
    15241 ttatcgagct tgtaagcccc aaaaataggc aatatatgat tatcgattag ctttttaaca
    15301 ttgccttgag tgtttggctt aaccgtattc ttataacttt ccaaccagag agttgccaat
    15361 tcttgatagt tttttatggt aacagccttt tgtctggtag atcctgcttt ttgaaaagct
    15421 attttttctt gattggcttt ctgcttaact tccttttgtg tccgacctgt tactttggtt
    15481 tttactttct ttcctgttac ctggtcaact cctagatata cattagcacg ataaactttg
    15541 ctaccgtctt tttttataac ttcagttatt ttcatgatga taaacctttc taaaatacat
    15601 cagcaggcaa gccattatca aaaaggtttt atatcatgct aggagctacg agaaccccct
    15661 tattttcgtt ttatttcttc cagtaaagaa tacatagcat taatgtggtt atatttttga
    15721 aattcaggat cttggttttg tgtaataaag tatacgtatt gtctaccaga tttgaattta
    15781 tcgatagctt gtttttccac taattttttt aaatatttta aaattgtatt tttgtggatt
    15841 tttagttttt cttccaaagc ctctcttgtt acgaaacggt gttcgattat taactctaat
    15901 atctttttct catattcgtt atcaatatcc agattatcta taagggaagt atcccataat
    15961 gtaaattcaa ctgagtctaa ttcagttcgt aaattgggat attttaaatg actctcttta
    16021 actgcttcca ttattttggg tataccagtt cccgcttttt cacataaatt taaaaatcta
    16081 aaaatttctt gtattaagta gtttcttgga tcagaatgtg ccccactaaa aaagtccttt
    16141 atgtcaattc taagtgttcc gccatttgtg aatatatacc tgtcgggata tctaattatc
    16201 attatccctt tttcgctttt atagtcgcta tgaataaggc tattaatgaa tgcctcacga
    16261 attgcaattc gtaattttga aattccaatt ctattcatag aattttcttg aatgttagag
    16321 ttgtcattta aagttagata taatttttca ataactaggt aaaagaaatt aaaaagatta
    16381 tcttcccccc atgtaccatc ataaatcaca cgatctttaa agcgattgtt ttcagaaaac
    16441 tcttttagaa catattctac gttatagtgt ggaataaact cttttattga attatgtgta
    16501 ccaaaaatta atagtccagc aactgttggc tttattttat cgtccttgcg atctcttcgt
    16561 aaagcattta tttttattaa aaattgttcg ttatccaact ttgaaaaagg gtgctccgca
    16621 tttatattat caaatttttc tctatatagc tttattgttt ctgtatctaa gtctaaaata
    16681 gaaaaatcct gaataagtgt gctatcaaaa ctttccttag cggaatctct taacatagag
    16741 ttgatttgct cttgtgaaca cctaaaatca ccagtcccct gacgaaaata ggtagatgct
    16801 atgttgtcat taagatatat aggtttatcc ttgtagtcta ccttgttaac agggataatg
    16861 acaatctctt ttccttttat atttacgact tcaacacttt cttcattaat cacatttcta
    16921 ttaattttat tagggttatt aagtaaacta tataattcgt ccagtacttt atcgggatca
    16981 ttaactccag aaatataaaa atctttattc tttgtattct ctgagacacc tagaattaac
    17041 agaccattat ttgtattagc gaaggaacaa attgttttca taccgtcttt agggaaagaa
    17101 tttttagctt ctttgaattc aacaccttgg ttctcccctg ataataacaa ttttggtata
    17161 tcgtattttc tcattttttc tccaatcaat ttgcacacgc attcgcacac gcgcgggaaa
    17221 aatagtttat ttttagttag ctaacagtgc tattaaaggt ttttttgaaa gtagattatt
    17281 cgcacacgca ttcgcacacg cgcttcagga ttgttgaaca ttgtggcgcg tgggttagtc
    17341 tataccccaa agtaacgcaa aatcatctag attttcttta tctttcttag cttcttgaag
    17401 agctaaagac ttaatttctt caaatagatt ttcaaacttt ttatataatt tgttgtaata
    17461 ttcttggttg aattccttat cttcaaaaac tatgtagaat tcactacttg ttttttgaaa
    17521 tacaatatct agccagaata ggatattact tgtctttagc gcaagggcat ttaaaacttc
    17581 atagttgtct ttgggattgt attcatttaa tgattcagtg atagtagtga gaaactcttc
    17641 aggactgatt gggaaatttt tactctttgc tagttcaatt atttccttgt ctcttttctc
    17701 tctctctttt actttctgaa aaattttatc ttttgaaaca ttttttacga ggtatttttc
    17761 ttcgtctaat tgtttatcta acatatataa aaattctttg taaacatctt tgtcagaaaa
    17821 gcgagggtca agatcagatt ttttcactcc caaataatca gcaagttttt gaagattgcc
    17881 agatgttggc attgatctac cttttacata accagttatt gtacttttag gaatttctaa
    17941 agcattatgc aggtctatct gtctgatacc tttttctttc ataacacggt taagattatt
    18001 agagaaatat tctctattct ttaaatcctg agggctattt tttgccattg ttaaaaactc
    18061 ccttacttta attctacaac ctgattataa cacaaaaaag acaaagtacg aaaaaaataa
    18121 aatttttcaa caacagcgtt gataaagtac gaaaaaaata gtaccatgat tttatcaatc
    18181 ttgaaaggag ctataagaat atggcacaat ggacgctaag agcgtgtcga gtaaatgcag
    18241 gttttacttt gcgccaagtg gctaagaagg tcaacaagaa ttttcagact atctcaaagt
    18301 acgaaaaaga tagtacgcta atcccttttg agctacttaa agagttatcg gaactgtatc
    18361 aggtaaaact ggacgatatt tttttaggag atagtacgaa aaaaatagaa ctaaatcaaa
    18421 aggaaatcta agaaaggagc aaaccaatgg aattagtcta catggacggt aagaaagagc
    18481 cgtatacact gagcagtatt gttgcggagt gtgcagaagt taagcacaga catttgaaga
    18541 ttttgctgaa taaacatcga gaggacttcg agagtttcgg aaaggtgcaa tttaaaattt
    18601 caccttcaga aagtgggcaa aatgtacggg actatatttt gaatgagcaa caagcaacct
    18661 tgctgatcac ttacttacga aatacagaac ccgtaaaaga gtttaagaag aacctggtca
    18721 aagcattctt tgaaatgcgt gaggagcttt ctaagttccg tatgcagagg gcgctagaaa
    18781 agccaaaaag aaaaaccttg catgacagta tagagacatg ggaggcaaaa cccaagcacg
    18841 cgcatagcac catgaacaac ctgctactaa aagcagtaac tgacatgaac gctaagcagt
    18901 taagggaaga acgtgggggc tataacggta ttgatagctt gaccagtgac gagctggagc
    18961 aataccaggc atttgaggat atggtaatag ccatgatcgg cttgaatatg agttaccaag
    19021 aaatcaaggc tatggcattc agaaataaaa aaacacgcca aagaagcgcg tgagagcaac
    19081 aaaaaaggct tagcaataac cacaccgcag agcctttcac actaacacta aaacgaattt
    19141 aacaaagcag gcaagctatt atcaaagagg ttttagtaaa gatttatacc tagattatag
    19201 catatttagg gcaatttgac catacggaga gcgccaactc tttaaactgg tactttctca
    19261 tgctctcaat ttggcgactc agagcgtgag gctatgaatt gcaagaaaaa ctgtataaga
    19321 aacaaccatt aaaaaccccc acactctcgg tcggcaaact tctgagcgtg aggatatcca
    19381 gtatagtaaa aggcattaaa agctcttaga gcaattacac aacatagaaa caaaggtaaa
    19441 aaacatgaca gaaacaacat acgagaattt aactagacat atagacagaa ttagcgcaga
    19501 aatgcgagaa attggcgaaa aaaatgggct tagtagactt tcattattgg caaatcagac
    19561 aaaattcatc aaagaaaatt tacaccgttt actttggatt gaacttcctg aattgaatga
    19621 cagccataaa atcgaggcag tttctaaaag cactacggga atgtttttcc acgctggtat
    19681 ttttgaaatg gacgctatgc gacaagcatt ctttaaacgc caagctatgc acttttttga
    19741 caacgaagca gagcaacagg cgtatataga acatgctgaa aaggagtatt tagaggctac
    19801 tataacctta aaagatattc tttttaactc taaaaatgga actcagagag taaataaaag
    19861 ttgtcttata gagaagtttg aggaggcaat gcaatgacac taaacctaga caacatgaca
    19921 caagcagagt ttgatgaagt aatggctgaa attaaggaaa aacgccccaa cctcttccag
    19981 tttattgctg attttgtaga tcgaaaagta agcactgagg aggtagacga atacctgaag
    20041 atgaaacatg aaaaacaagt ggaatttatc aagaattatc aagcgagggc ataacatgaa
    20101 tgagttagat ttgaccaata cacaatcggt aatctttatg gtggtattga ttggcttact
    20161 gctttaccta aaccaccgag accgcaaaaa aagcgcccaa tttgagcgag aaaaccaaca
    20221 gaggatagaa acacctagcg aggatttaag ccctgattat gggcgttata tccagcttgc
    20281 aggggtaaga gtttacggag gaactgaatg agtctatcag agaatgacaa acgagtatta
    20341 agactaatca aggtaggggc tgagaactcc ataacagggg cagaaatcag ccttataact
    20401 aagctggcgg aaagaaccgt acaagatatt atcagccgtc taatcacgcg tcatagtgtt
    20461 cctattgttg gggttcgcca tgggacattt agaggatatt ttatcccagc taacaaagag
    20521 gagctactgg acggagcaaa ggcattctat aaccaagtac aggaagaaca gaaacgccta
    20581 actgtccttt tgaatgctga tttagagagt tacaaagaaa ccttgaagga ggtgggcgga
    20641 tatgtttagc ctaagccgag aaagtgagca agacctagcg catggcattc tggaggtagt
    20701 agaaagatac ctggaagcgc gtgatacagt caagccacga ctgacaggtt taatatcagc
    20761 ccaggaagtc atggacgagt tagatataaa atacatgaca ctccaaaagt gggaaaaagc
    20821 agggctaaga cggtatcagc caccgctaga agatactagg aaaatctatt ataaaatatc
    20881 tgacatctgg aagtttttgg gggtggaaaa tggcaaggta tagtattcat ccggcagata
    20941 ataaagggca ttatcacaat attaaatttt acaaagagcg caggccaacc ctagaccagc
    21001 taaaggaaca gcaaaggctt aaaaagctga agaaaaaacg caaaaagggg cgatagtatg
    21061 acaatttatg aggctaaagg ctttcagagt aatcttgtct atccatttga taaaattgag
    21121 cctttccagt atattgaacg attcaagccc ttagtagttc ctgaaggggc agatattgag
    21181 gaatacaagc gaactcaagc gccttactgt ataagtggca aagtgacgcc agaaaagcat
    21241 ggcagttaca agcgaaacaa ctccagtcta atctatcggg atttgatttt ccttgattat
    21301 gacgatatac aggggacgtc tgagggcttt ataaaagcca tttctagcgc tttatttggc
    21361 tactcttaca tcttataccc gactatcaaa catagcttag aaaagccccg ttttcgcctt
    21421 gtagtgaagc ctgacaacgt gatgaatgag gcgacctata agcaggtagt gaaagagatt
    21481 gctgacaaga ttggactccc ctttgatatg gccagtttaa catggtcaca actccaaggg
    21541 ctaccagtca caacaggcga cccagcaagt tatcaaaaga ttgtagagca tggacttgat
    21601 tatccagtac cacagacaac ggctgaacca gtcaaacaga atgcggcaag ccttccatac
    21661 actccaaggc caagcgggca gaaatctatg accatgagga tcattgacac gcttttcaac
    21721 ggatttggag acgagggagg gcgcaacgta gcactgacac gatttgtagg cttactcttt
    21781 aataagtggg ttgattgtga cctagagaca gcctatgaac ttacaaagat agccaatagc
    21841 gtgacagttg aaccattgcc gattgaggag ctagaccgca cttttagcag tatagcacgg
    21901 gctgaatata gaaagagagg ttagaaccat agaactagaa gaattagcaa acctaaaaag
    21961 tgaaatcttg gaggtaatgg agcaagaaca ccctcctaga acgatgaagg agcttgaaaa
    22021 tcgtatcttt aaagctggag aagaatggcg ggcagaacat actgaaacta aggtaaatga
    22081 gaacacaggg gacgttaccg aaaaggttgc catgccccaa accttcacag tagctaaaat
    22141 actgagcgag attgtcacat ttacttttat cagcaagagc aatatacctg attatagcct
    22201 actctatatc tatgatttag acgagggtat ctataccgct agtaatgatc tattcaatct
    22261 tttgtgtaag acctttgacg ttagaattaa acccagagag tggccacaga ttaagttaat
    22321 ggttagaaca ttggcaaaga tacgaaaacc tttagaaagt gctaacctca ttcccgtaca
    22381 gaacggcatt atcaacttag aaactaagga actactcccc tttagtccta agtatgtaat
    22441 tacaagtaag ataagcacgg cctaccacgc gcctaaacga gtcccaacag atagagaggg
    22501 aaaaactttt gatgattggt tgaactcaat cgcttgtaat gatagtgaac tggtaacact
    22561 gttttggcag attatccttg aagctattga ccctaaccat actcgaaata agtttgctat
    22621 cttctacggg gacggtaaca atggtaaagg gacatttcag cgcttcctta tcaacctgat
    22681 aggggaaagc aatatatcag ccttaaagcc tgcacagttt gctgaaaagc ataacttgga
    22741 gaccttggta ggtaaggttt gtaatattgg ggatgaagca cctaacgaat acttaaaaaa
    22801 tccgtctgat ttaatgagta tcactagtgg cgacactgtt ctagtcaatc caaaaggacg
    22861 cccagccttt gaagctactt tcaagttatt caatatcttt tcagggaatt atatccccaa
    22921 tggtggcaac aagacaaaag gctggtatcg tagaattatg attgtccctt ttaatgctga
    22981 ctttaacggg gagaaggaaa aaccttggat aaaaaatgag tttttagcaa acaaggaagt
    23041 cctagaatat gccctctaca aagctatcaa tcaagagcca tttactcact ttatcgaacc
    23101 taaagcagtt aaaggactcc tagaagaata ccaggaagat aatgactact tactttcatg
    23161 ggttaagcat gaatacatgg aaaaaggttg gcatgagctg gacgtagtac ctgtttttat
    23221 cgttacaaga tcactaaagc actatgccga agatatggga atacccaagc ccaatgttta
    23281 cggggctggt aaagaaacta tcaagcactt acaacagttg acacctaatc ggtattctct
    23341 aagaaagaaa agagtttctc cagaagattt tgaaaaacta gaggcatggg acgttgacaa
    23401 gataaaaatg cggacacctc aacactctat cactaaacaa gaataagtgt gacgttcttt
    23461 ttttgcttaa acccttgata atactgattt tcttgaaaaa agtgtgacgt tgtgtgacgt
    23521 tctcaaaaaa gaaggtcaca ccccttgaag ccttgatata tctaacttta ggggaatagg
    23581 tgtgacgttg tgacattctt tccaactctt atatatagag aaaaatacag tatttatata
    23641 tataggaacg ataaaacaaa agaacgtcac agggtcacag gggtggtgaa acacctagag
    23701 cctcaagggt ttgaacgtgt gacgttcttt gtcacaaaag gtcacagaaa acgaaaaata
    23761 ttacataatt taccttaaaa caaagaaatg acaacaacat gaaagttaaa ctatttgaat
    23821 atactagacg atgggaaaaa gaagactttg agaaagagat cgatgacttc atggcaactg
    23881 ttgaagtgct ggacgttaaa ttttctggta caccatctag tgaatccttt aattcggtgg
    23941 ctatcgtatt ggtattatac agataacaaa atggggtaga tagtaccgac ccccttgcaa
    24001 tggtgtaact actagtgaca cccttaaaaa cagaaagagg aaaaacaaca tgacattaaa
    24061 aacattttca tctaaagcca aaacatttac tttcacttac gaatttaaag acctagatac
    24121 agctctggta gcaggtcacg cgttactggg atatatgact ggaacatatt gccagcctgt
    24181 aatctcattg acctacaagg ataaaggcac gctagtagct gagtatgtgg aagatcacaa
    24241 gctaaacaag acctttaagc gtatttgtga cagttttaaa gactaccaca aacaaccagg
    24301 agaggctgaa gcatttgaag aacgttacaa acgggagcgc gtgctccaac tcaaagagtc
    24361 agaggacttt gagagtttac tgaataaggt cacagactac gagctggaac tattagacta
    24421 tgctgaccgc ctgctttctg ataagcctat ccctatggac tctatgactg cttttgctac
    24481 gttggaaatg ctgggcgatg aaagtattag cctactccaa aagttggacg tagagggcga
    24541 atataaaggc cttgctggtt atacagagca tttgaagtag aatacagggg agcaatcccc
    24601 tttttgctat caagtcaata gttttgggtt tttccatata gggggaaata atgaagcagt
    24661 tagcaataga agcaatcact aaaccaatga agctgagagg aatatctaag ggtatagccg
    24721 agttggatgg tcaacgttta gagattgatt tggatagttt aatgattgat tttggtggag
    24781 agtcatttga attagacaga atagcaggaa ctaagggagg taatcgatat ttttttcttt
    24841 gccctgattg tggtagacgg tgcaggttgc tttataaacg gtatttgtat tttagttgcg
    24901 gtacttgtct agatatccac aagcacaccc tgaaccgcag taaaacggat tgccaatact
    24961 actgggagct tgcactaaaa gaagctagaa aggtagaacc agggtggagt cctagacgtg
    25021 gcggatatat gtttgatagt tttcctgaaa gaccaaaata catgaaacag aaacgatatt
    25081 acaagcatta tcaaaagttt attaactaca ccagaaaagg ggatagcttt tggctgaatg
    25141 gtttgagttc tctaaggtaa tttgtagtag tgtgcaattt acaaaacaaa caaatactac
    25201 atattagacg gtttgaatgt taaaaaagct agatatatca aggatttaat taagtatagc
    25261 gttccaaaaa aagggtgcag taagcgttcc aaaaaagggt gaggttgaat atttaaaaaa
    25321 ggctaagatt aggctaaggt cacatacttc aaaatagcaa ggttttagca aggtacaggg
    25381 cttttttcta gtgatagaac cccaaggtta ccacaaggta tagctacttt tttagaacca
    25441 tagaacggta aggttacggt aaggtatcga agttttccaa tggtaaggtt ttggtaaggt
    25501 agcatatata aaaagtacaa ggttagtaca aggttacata cttaaaaata ctaaggtttt
    25561 acaaaggtag agaggtttac cgagggttag aaaaggtgag attttgctta ggtagtggca
    25621 gtaaatatgc ctgacaaatg gcagggttat gtgtgttgaa ctccgagcga acgccgagaa
    25681 agtggctata tcccccctat catttatcaa gtagataaga gcaataaaaa ccctccttaa
    25741 ccccctgaga aacgacaagc agataagaga agtttttagc cctcttattt cggatctact
    25801 ccttgcagaa tgacaagcag ataaggacga caataagcct tcttaactgc ttacaaaacg
    25861 atagggagtt aagacgaatt taaaagcccc ttattttcgt ttttctcctt gtcaaacggg
    25921 aaggaaataa gacaggaaat aacatcgctt attttgattt tgctccctga aaaactgtaa
    25981 ggagataagg agacttatta gcttccttaa tttgaatttt ctccttacaa aatgacaggg
    26041 aaataagaac taaaataact ccccttattt tcctaccaaa tgataaggag ataagagcag
    26101 tttaaaagtc tgttattttg gatttgttgc ttacaaaatg ataagcagat aagcaaagaa
    26161 ataacttgcc ttaattgctt gcagaatgac aaggaaataa gagagataaa aacatccctt
    26221 aattgcttat caaatggtat ggagaatgga cttgaaccta gagcgaagct agagaaaatg
    26281 aaaaaaagcc agcacagggc tgactccttt atgaattatt ccataaaact attatatcac
    26341 aaaggaggcc gaggcatgac accagagcaa gtaaaagaaa aactagaggg cgttaagtgg
    26401 ataaacaagg agatcaaagg cttatatttg gaattggaaa ccctggaagg tggcattatc
    26461 aaaaaaccaa cactaagcca tagcagggtg cagacaagta gagagaataa gacagagaac
    26521 aatcttataa gtgttctgaa gctaaaagag gacactttac agagaattga gcgacttact
    26581 gaagagagaa tgaaaatatc tgagctaatc gataaactgg ccaatccgct tgagcgttct
    26641 gttctaagac ttttttactt gaatgatctt gtagtttcgg aggtggctga agaaatagat
    26701 agatcaaata ctacagtata cattataagg caaaaagcta tagaacactt aacaggtatt
    26761 gtaaacgggg attgatttaa ccttaccacg gaattaggag agtatggggg agtcctaagc
    26821 cacatattcg cccgtatttc gctttgtttc gtactggaca actaaaacac catggataaa
    26881 ctacaaaccc tcagaaacga atctgggggc ttttgtgagg tcataatctt ataaaccacg
    26941 cgcttcatgg tataatatat ctatcagcaa ccagcaataa aaaagcacgt ttgaccgtgc
    27001 tagtttcttg cctgctgaac tcgtcaaatc ttagcccttt tgtggggctt ttttgctccc
    27061 ctttttgcgt actttggggg agcaagtagt aaaaagtaat gttagtaatt tttattaaaa
    27121 agcgcgtgat ataagggtta ggaagcccta aggaaacata aaataagcga ttgttgatta
    27181 tactacaaaa tcggcctttt gggtaataga atctcacttt ttttggtata atggtaagca
    27241 ataatggact agaaagaaca aagatgcaag ataaaattgt cattcatggg gcgcgtgccc
    27301 ataatttaaa aaatattgat gtggagattc cgcgagacaa gttggttgtc gtgactggct
    27361 tgtcaggttc agggaagtcc agtctggctt ttgatactct ctatgcggag ggacaacgtc
    27421 gctatgtaga gagtttgtct gcctacgctc gtcagttctt gggaaatatg gaaaaaccag
    27481 atgtagatgc cattgatggt ctcagcccag ctatttccat cgaccagaaa acgactagta
    27541 aaaatcctcg ctcgacggtg ggaacgacga ctgaaatcaa tgactatctg cgtctcctct
    27601 acgcacgtgt ggggacgcct tactgtatca acggacatgg agctatcaat gcttcttctg
    27661 tggagcaaat cgttgataag gttttggagt tacctgaacg ccagcgcttg cagatcttgg
    27721 ctcctgtcat ccgcaagaaa aaaggccaac ataagagtgt tatcgagaag gttcagaaag
    27781 acgggtatgt tcgtgttcgt gtggatgggg aagtctatga tgtgaccgaa gtgccagagt
    27841 tgtctaagag caagcaacac aatatcgatg tcgtggttga ccgtattgtt atcaaggagg
    27901 gcattcgtag ccgtctcttt gattccattg aagctgccct tcgtatcgca gaaggttatg
    27961 tgattatcga caccatggac gactctgagt tgttgttctc tgagcattat gcctgtccag
    28021 tttgtggatt tactgtccca gagttagagc ctcgtctctt ctctttcaat gctccctttg
    28081 gctcttgtag tgagtgtgac ggcttgggga ttaagctgga ggtggatact gatttggtag
    28141 tgccagatgc cagcaaaacc ttacatgagg gagcgctggc accttggaat cctatctcat
    28201 ccaactacta tccaaacatg ttagagcagg ccatgaaagt ctttggagtg gctatggata
    28261 agccttttga ggacctgtca gaagaagata agaacttgat tctctacggc tcagatggta
    28321 aggaattcca tttccattat gaaaatgaat ttggtggtgt gcgcgatatc gacattccgt
    28381 ttgagggagt tatcaataat atcaaacgtc gttaccatga aaccaatagc gattacactc
    28441 gcactcagat gcgtctctac atgaatgagc tgacctgcgg aacctgtcaa ggctatcgtc
    28501 tcaatgacca ggccttgtct gtccgtgtgg gcggccagca agggccacat attggagaaa
    28561 tctcagacct gtctatcgct gaccacttgg acttggtgag ccagttaact ttgtctgaaa
    28621 atgaagccat cattgctcgt cccattctca aggaaatcaa ggatcgtttg accttcctta
    28681 ataatgtggg tcttaactat ctaaccctgt cacgttcagc aggaaccctt tcaggtgggg
    28741 aaagtcagcg cattcgtttg gcaacccaga ttggttccaa cctatcaggt gtcctctata
    28801 tcctagacga gccgtcaatc ggtcttcacc agagggacaa tgaccgcctg attgccagtc
    28861 tgaaaaagat gcgtgacttg ggcaatactc ttatcgtggt ggaacacgac gaagatacca
    28921 tgcgtgaagc tgattatctg attgacgttg gtcctggtgc cggtgttttt ggtggtgaga
    28981 ttgttgcagc aggtacacct aagcaagtgg ctcgcaacag caagtctatc acaggtcagt
    29041 acttgtcagg caaacgtgtc atcccagtac cagaagagcg ccgtgtcgga aatggtcgtt
    29101 ttattgaagt gacaggagcg cgtgagaaca acttgcaaaa tgtcacggct cgctttccac
    29161 taggaaaatt tatcgcagtg acaggtgtgt cgggttcagg gaaatcgact ctaatcaaca
    29221 gcattctcaa aaaagccatt gcccagaagc tcaaccgtaa ttcagacaaa cctggtaagt
    29281 ttaagactat tacagggatt gagcatgtcg accgtttgat tgatattgac cagagcccta
    29341 tcggacggac gccgaggtct aacccagcta cctatacagg agtttttgac gatatacgtg
    29401 acctttttgc tcagacaaat gaagccaaga ttcgaggcta caagaagggg cgcttcagtt
    29461 tcaacgtcaa gggaggtcgc tgtgaagctt gctcaggtga cgggattatc aagattgaga
    29521 tgcacttctt gccagatgtt tatgtggctt gtgaagtttg ccacggaacc cgctataaca
    29581 gtgaaaccct agaagttcac tacaaggaaa agaatatttc gcaggtcttg gatatgacgg
    29641 tcaacgatgc ggtagaattt ttccaacaca ttccgaaaat tcaacgcaaa ctccagacca
    29701 tcaaggatgt aggtctaggc tatgtgacct tgggacagcc agctaccacc ctttctgggg
    29761 gagaagccca acgtatgaag ttagctagcg aactccacaa acgctcgaca ggaaaatctt
    29821 tctacattct ggatgagccg acgacagggc ttcatacaga ggacattgct cgcctgctca
    29881 aggttttagc tcgctttgta gacgccggca atacagtcct cgtcatcgag cacaatctgg
    29941 atgttatcaa gacggcagac catatcattg acttgggacc tgagggcggt gtcggtggtg
    30001 gaaccatcat cgtaacagga actccagaag aagtagctgc caacgaagcc agctatacag
    30061 gacactattt gaaaggaaag ttacatcatg aataaacgcg tacaagcatt tctagctaaa
    30121 atgcaagaaa aagaactaga tggtatcatc atcaacaatc ttaaaaacgt ctattatttg
    30181 actggttttt ggggctcaaa cggaacagtc tttatcagtc gtgaccgtca ggtcttagtg
    30241 acagactctc gctatatcat cgcagctaag caagaaacca gtggttttga gattgtggct
    30301 gatcgtgatg aattggctgt cattgcagga attgttaagg acatgggctt gactcgtatc
    30361 ggttttgaag atgagatttc agtgtcttat taccaccgta tgcaggcagc ttttgcaggt
    30421 ttgaacttgc ttccacaaac tcagtttgtg gaaggtcttc gtatgattaa ggatgaggca
    30481 gagattgcag cgattcgcaa ggcttgttct atctcagacc aagctttccg cgatgcgctt
    30541 gactttatca aaccaggaaa aactgaaatt gagattgcca acttccttga tttccgcatg
    30601 cgtgagttgg gagcatctgg cttatctttt gatacgatcc tagctagcgg tatcaattct
    30661 tctaaacccc atgcccatcc aatgcacaaa ccagtggagt tgggagaagc cattaccatg
    30721 gacttcggct gtctctatga ccactatgtc agtgatatga cccggactat ctatctaggg
    30781 catgttagcg atgagcaggc agagatttac aatacggttc taaaagctaa ccaagccttg
    30841 attgaccaag ctaaggcagg cttaggtttc cgtgactttg acaaaatccc tcgtgatatt
    30901 atcattgagg caggttatgg cgactacttt actcacggca ttggccacgg tattggtctg
    30961 gatatccatg aggaacccta ctttagccag acttctacag aaactattaa gacaggtatg
    31021 gccttgaccg atgaaccagg tatctatatc gaaggcaaat atggcgttcg tatcgaggat
    31081 gatatcctga ttacagagac aggttgtgaa ttattgaccc tagctccaaa agagttgata
    31141 gtcatttagt tgtttgtcaa gaaaaaagta cgaaaatgac gaaaaaagtc aaaaaaaatt
    31201 aaaaataggt cgcaagtcgg atgtttttta tggtataata gactaaactg atagtaacat
    31261 gtagcgaaag gggtaggtac atgattaaaa tttatacagt ctcaagttgt actagctgta
    31321 aaaaagcaaa aacctggctc aatgcccacc agttaagtta taaagaacaa aaccttggta
    31381 aagaaggaat tacgagagaa gaattactgg atattctaac caaaacagat aacggaatag
    31441 ccagcatcgt ttcgtctaaa aatcgctatg ccaaagccct tggagtggat attgaagatt
    31501 tgagtgtcaa tgaagttctc aatctgatta tggaaacacc gagaatttta aagagcccaa
    31561 tccttgtaga tgaaaaacgc ctgcaagttg gctacaagga agacgatatt cgtgccttcc
    31621 taccacgctc tgtccgtaat gtagaaaatg cagaagcacg tttgcgtgca gctctataaa
    31681 catcaaggct gggagcactt cccagtctta ttctatttta atttcaaaaa gaaagaagaa
    31741 agaaatgaaa aaaatagttc ttgttagtct agctttcctt tttgtcctgg ttggttgcgg
    31801 acagaaaaaa gaaactggac cagctacaaa aacagaaaaa gatacgcttc agtcggcatt
    31861 gccagttatt gaaaatgctg agaagaatac agttgtaact aagactttgg tcttgcccaa
    31921 gtcagatgat ggtagccagc agacacaaac aattacttac aaagacaaga cttttttgag
    31981 tctagctatc caacaaaaac gtccagtctc tgatgagttg aagacttata ttgaccaaca
    32041 tggagtggag gaaactcaaa aagctcttct tgaagcggag gagaaggata agtctatcat
    32101 tgaagctcgt aaattggcag gtttcaaact tgaaacaaaa ctattgagcg caacggaact
    32161 tcaaacaacg actagttttg attttcaagt tctggatgtc aagaaggctt cccagttgga
    32221 acatctgaag aatattggtt tggaaaatct tttgaaaaat gaaccaagca aatatatttc
    32281 agatagattg gcaaatggcg cgacagaaca atagaaaatc caaataaata gactgcctga
    32341 attgtagaag gtaaggaatt atgctataat ggtactattc taaggaaaga gggtgttaga
    32401 atgggattta ctgaagaaac agtacgtttt aaattggacg attccaataa aaaagaaatt
    32461 agcgaaactt tgacagatgt ttatgcttcg ttgaacgata agggttacaa cccaattaac
    32521 caaatcgtag gttacgtatt gagtggagac cctgcctacg ttcctcgtta taataatgca
    32581 cgaaatcaaa tccgtaagta tgagcgtgat gaaatcgttg aggaattggt tcgctactac
    32641 ctcaaaggac aaggagtcga tctataacct atgagaatta tgggattgga cgtcggttca
    32701 aaaacggtag gggtggcgat tagcgatccg cttggtttta cagctcaagg gcttgaaatc
    32761 atccagataa atgaagaaca aggcaaattt ggttttgacc gcgttaagga attggttgat
    32821 acttacaagg tggaacgatt tgtagtgggc ttgcctaaaa acatgaacaa tacaagtgga
    32881 ccgcgcgtgg aagctagtca agcatacgga gcaaagctag aagagttttt tggtttacca
    32941 gtagactatc aggatgaacg cttgacaaca gtggctgctg agcgcatgtt gattgaacaa
    33001 gcagatatca gtcgcaataa gcgcaagaaa gtcattgata agttagcagc tcagctgatt
    33061 ttacaaaatt atttagatag aaaattttaa tataaaggag aggctatgtc acacgatcat
    33121 aaccacgacc acgaagaacg tgaactaatc acactagtag atgagcaagg aaatgaaacc
    33181 ttgtttgaaa tccttttgac aattgatgga aaagaagaat ttggtaaaaa ctatgttctt
    33241 ctagtaccag ttaacgcaga agaagacgaa gacggacaag ttgaaatcca agcttactca
    33301 ttcatcgaaa acgaagatgg aacagaaggc gaattgcaac caatcccaga agactcagaa
    33361 gacgaatgga acatgattga agaagtcttc aacagcttta tggaggagtg atacagtctg
    33421 ggagactgta tcagcccaac tcccagaaat ggggaagagt tggaacatcc agtggatgtt
    33481 tttagcccag ttcctttaaa taagagagaa ctggtaggtt cgggggacgt ttttagcctg
    33541 acgctaaaaa taaaaaccgt cagtaagtcc ggggggcgtt tttagcccac gttcacattc
    33601 atagtagcta gttattagct aaccaggtaa gaggtcggga cgaaaatcct ggccttgttt
    33661 ttattagtaa ctatacttta atgcgataat tgattggact tttgtcaagg agatgtgtat
    33721 gtttgaagta gaagaatggc ttcatagtcg gattggtttg aattttcgat caggtttggg
    33781 ccgaatacag caagcggtgg atttgttagg aaatcctgag cagtcttacc ctattatcca
    33841 cgtaacaggg actaatggga aaggatctac cattgctttt attagggaat tatttatggg
    33901 gcatggcaaa aaagttgcga cctttacctc ccctcatatc gtatccatca atgaccgaat
    33961 ttgcattaat gggcaaccta tagcagacgc agactttatc cgtttggctg atcaggtcaa
    34021 ggagatggag aaaacgcttc tgcaaactcc tgaccagttg tccttttttg aattgctgac
    34081 cttggttgct tttctttatt ttagggagca ggaggtggat ttggttttat tagaagtggg
    34141 aattggtggc ttacttgaca cgaccaatgt ggtaactgga gagcttgctg tcatcacctc
    34201 cattgggctt gaccatcaag aaaccttggg tgatagtcta gaagcaattg cagagcagaa
    34261 agctggtatt ttcaaggctg gtaaaaaggc agtgattgcg aaattgcctc cagaagctag
    34321 acttgtctgt cagaaaaaag ccgaatcttt agctgttgac ctttatcagg caggtcaaga
    34381 ttttttaatg ctgaatggtg atttttcaag ctctttacta aatctttcac agctgaacat
    34441 aggcttagaa ggagtctatc agcaggagaa tgcagccttg gcgttgcaaa cttttcttct
    34501 ttttatggga gaaggaaagg aagctgttga tgaacaggct gtaagaaagg ccttggaaca
    34561 gacccattgg gctggtcgct tggagcgtat tcgcccacag atttacttgg atggtgctca
    34621 taacctccct gccttgactc gcttggttga gtttatcaaa gaaaaagagc aggaaggcta
    34681 tcgacctcaa atcctttttg gagccttgaa acggaaggat tatcaaggga tgttaggtta
    34741 cctgactgaa aaattgcctc aggtggaact caaggtgacc ggctttgact atcagggggc
    34801 tttggacgaa agggatgtga caggttacga tatagtttct tcttaccgag aatttatcag
    34861 cgattttgaa gaaagagcag atgctcagga tttgctgttc gttacagggt ctctctattt
    34921 tatctcagaa gtacggggct acctgctgga ccgtgagcag ataaattgac ccccttgttt
    34981 gaacttgtta tactagggga attgctggtt agagaaaatt tctctaaatt ggtagcagaa
    35041 aggaaattca tcatgaaatt aaaaagattc acactttctc ttgcttctct agcaagtttt
    35101 agtctcttag tagcttgttc acaaagagct caacaggttc aacagcctgt tgctcagcag
    35161 gtccaacagc ctgctcaaca gaataccaat actgcaaatg caggaggtaa ccaaaatcaa
    35221 gcggctccag tacaaaacca acctgttgct caaccgaccg atattgatgg gacttatact
    35281 ggtcaggatg acggagaccg tatcacttta gtggtaactg gaacgactgg tacatggact
    35341 gagctcgaat ctgacgggga tcagaaagtc aaacaggtta catttgattc agcaaatcaa
    35401 cgcatgatta ttggcgatga tgtcaaaatt tacactgtaa acggtaatca aatcgtcgta
    35461 gatgatatgg atagagaccc atcggaccaa atcgttttaa ctaaataaga ctatgcaagt
    35521 agaaagggct ggatttttca gcctttttac ttttacctag aaaataatca taaatacttg
    35581 ccttctaccg aatacctgcg ttatactagt atcaattact tgtttttagc attcaaacta
    35641 tcaaggaggg gatatgaaat ataggaaatt tcaattattg atgtccaagt atggctttag
    35701 tctttcgatt atgctacttg aactttgtct tgtttttggt ctctttcttt atttaggacg
    35761 catggctccc attttatgga ttactgtcct cattctactg agtatcatca caatcatttc
    35821 gatagtcaac cgtaatacga ctcctgagaa taaggtaacc tggttgttag tagcctttgt
    35881 gccagtattt ggtcccttgc tctatctgat gtttggtgaa aggcgattgt ccaaaaaaga
    35941 aatcaaacaa ctgaagaagc taggctctat gcatttccaa gaagcaaata gccagctact
    36001 aaaagagaaa ttaaaagaaa gtgacaaggc agcttatgga gtcatcaagt ccttattgag
    36061 tatggatacc aatgctgaca tctatgatca aactgcctct acattttttc ctaacggaga
    36121 agctatgtgg aaaaagatgg tagaagatct taaaaaggct gagaaattta ttttcttgga
    36181 atattacatt atagaagaag gtttgatgtg gaatcgcata ctagatatac tagagcaaaa
    36241 ggtagctcag ggtgtagagg ttaagatgct ctatgatgat atcggctgta tggctacttt
    36301 aacaggagat tatgcacatc gacttcgtca gctgggcatc gaggcccata aattcaataa
    36361 agttattcct cgtttgacag tggcttataa taacagagat catagaaaaa tattgattgt
    36421 tgatggtcag atagcctata ctggtggggt caatctggca gatgagtaca ttaaccacgt
    36481 cgagagattt ggttattgga aggatagtgg aattcgctta gacggactag cagtaaaagc
    36541 tctgacacgc ttatttttga ccacttggta cattaatcga ggagaaatta gtgattttga
    36601 tcaatatcat ttagaaaatc attctatccc gagtgacggt ttaaccattc catacggaag
    36661 tggacccaag ccaatttttc gagcgcaggt agggaaaaaa gtttatcaga gtttaatcaa
    36721 tcaagcaaca gaatcggtct atattacgac accttatttg attatagatt atgatttaac
    36781 agagacaatc aaaaatgcag ctatgagagg ggtcgatgtt cgaattatca ccccttacat
    36841 accagataag aagttcattc agttagtcac gagaggagct tatcccgacc ttctttctgc
    36901 tggtgttcgg atttatgagt atagtccagg ttttattcat agtaagcaga tgttggtaga
    36961 cgaagatttt gcggtggtgg ggacaatcaa tctcgactac cggagcttgg tacaccatta
    37021 tgaaaatgca gtcttactct ataaaactcc ttctataagg gaaatcgccc gagattttcg
    37081 aaatatattt gcagattctc aggaagtcta tcctcattct atcaaaacga gctggtatca
    37141 aaagcttgta aaagaaatcg cccaactatt cgcccctatc ttataagaaa tctagaactt
    37201 aggatacaaa ccagacctat ttttcttgtc ttttacgaat agaaagaaag aggaggggaa
    37261 ttcatgctaa ctaaggaaga agtgaatgat atgattgagt tcaaacagac acatttacac
    37321 cgctttcggg aaattgaaac ctttgtgaaa ctatgcaaaa aatcactcaa acagccatcg
    37381 caagctgaca atcctaggac tttttgatat actaagacag ataaattgaa caggagaaac
    37441 gatatgagtg tgtatggtag agtagaagaa gttcataagg agaatcgtga acctctagaa
    37501 taccaaattg aacaagaatc gcatcatcgt gaatcaagtc gtcttccttt ggtgaaaatt
    37561 ttactatgga gtacgcttgt aacggggata actctaggag taccgctatt actcgactta
    37621 atgagtgcac aagaagtgca ggatttttat gcaggttggg cgcttcatca gacagggaag
    37681 atttacagcg actattatgg aagtcaaggt ttgctttatt atttgctgac ttacgtgagt
    37741 cagggcggat ttttctttgc catctttgag tggttagcct tggtagcagg cggatttttc
    37801 ctttttagat cagcggacac cttgacaaat caaggagacc aagctggaca actggtgact
    37861 attttttaca tgctagttac aggtcttgct tttggtggag gctatgcgac tcttttagcg
    37921 cttcctttct tattcgcagc ctttagttta gttgcggctt acctaagcaa tccaagccat
    37981 gataagggat ttgtacggat tgggctagct ttggcaggcg gatttttctt tgctccctta
    38041 tcatcgctcc tgtttattgc tgtagtgagt ttaggcttgt tggtctttaa ccttgggcat
    38101 agacgctttg cgcatgggtt ttatcagttt cttgcagtgg ctttaggttt ttcacttgtc
    38161 ttttatccaa ctgcctacta tagtgctgca acaggaagtt ttggggatgc gattagtggt
    38221 attcgttatc ctattgacag tattcgcttt gattttactt ctaaaatttt agagaatatg
    38281 tttttttatg gcttgttgtc ccttggtttg ggatttgtgg tttgtatctt tttaggtctc
    38341 tttcaatcca aaccctttaa actatacgtc atttcggttc ctgcaagtct tgtggtaatt
    38401 ttaggtttga ttttactttt cttttcacaa gagcctctgc acgcttctta tttgatggtc
    38461 gtcttccctg ttttcctact tttattggta accaatatta agagtcaaca gagggggcgt
    38521 agtgctagaa gaagccgaag agaaacgcca gttagcctat ggagtcgttt cttcaaagga
    38581 aatctatatc tgctagtttt tgggtttgtc tatcttttgt ctgttccttt tttgatgaag
    38641 tttgtccttt atccagtacc ttatcaagaa cgtaatcgtc ttgctgattt ggtaaaagag
    38701 gagacaaata cggaagatgc tatctatgca tgggatgata ctgcgactct ttatcgtaag
    38761 agtgagcgct tgtcgccatc ggcgattttg tccccgttgc actatacagc aactgaggaa
    38821 aatcgtaata agttacttaa tgacttgaaa gaaaaacaac ctaaggtgat tgtggtaaat
    38881 gacaaggtgg aagtctggtc tgaagtggaa acactcttaa aagaaaatta ccaacaagta
    38941 aagactgatt actcagagtt taaagtctat aaaattaaat aaccaaatca atatcttgtg
    39001 tatttttaaa aattttaaga tttttaacac aagatattga tttttctttt tagagtggta
    39061 taatactttt tagaaagaac attttagaaa agagcatgca tatgattgca ctagaagaaa
    39121 aaattacaat tttgccaact ctcttcgtcg agaaacgaga tgggagacgt gttgtatttg
    39181 atgtggacaa gattgacaag gctctccaca aggcagctga caaggttatg gatgtgacac
    39241 ccctggttga aaaacgcctc aatgacctga ctgagagaat tattacagaa attcatagtc
    39301 gctttccaca gggaattaag atttacgaaa ttcaaaatat cgtagaacat gaactccttg
    39361 aagccaaaga atatgcgctg gctgaggagt atattactta tcggacacag agggattttg
    39421 agcgctcaaa agcgacggat atcaacttta gtattcataa acttctcaac aaagaccaga
    39481 cagttgtcaa tgaaaatgct aataaagaca gtgatgtctt taacactcag cgtgatttga
    39541 cagcagggat tgttgggaaa tcaatcggac tgcaaatgct tcctaagcac gtagccaatg
    39601 cccaccaaaa gggggatatc cactatcacg atttggacta cagtccctat acccctatga
    39661 ccaactgctg tttgattgat tttaagggta tgttggaaaa tggttttaag attggaaatg
    39721 cagaggtaga gagtcccaag tctatccaga ctgcgacagc acagatttct caaatcattg
    39781 ccaacgttgc ttctagccag tacggtggct gttcagctga ccgtatcgat gaaattttgg
    39841 cgccttatgc agagaagaac tatcaaaaac atctcaaaga tgcagaagag tgggtattgc
    39901 ctgaaaaacg ggaagattac gcttggaaga aaacgcaaaa ggacatctac gatgccatgc
    39961 aatctcttga gtatgaaatc aatactctct tcacttcaaa tggacaaaca ccttttactt
    40021 cgctaggttt tggtctggga accagtcgtt ttgaacgaga aattcaaaaa gctattttaa
    40081 acattcgcat caagggtctt ggttcagaac accgtacggc tatctttcct aaacttattt
    40141 tcactctgaa aagaggcctt aatttagaag aaggaactcc caactacgac atcaagcagt
    40201 tggctcttga gtgtgcaacc aaacggatgt atccagatgt tttatcttac gataagattg
    40261 ttgacttgac aggatccttc aaggtgccta tgggttgccg ttctttcctc caaggatgga
    40321 aggatgaaaa tggtgtagaa gtcaattcag gtcgcatgaa tctgggtgtt gtgacggtta
    40381 atctgcctcg tattgctctt gagtctgaag gtgatatgaa taagttctgg gaaatcttca
    40441 acgagcgaat gaatatcgca gaagatgctc ttgtttaccg tgtcgaacgc actaaagagg
    40501 cgacaccagc gaatgctcct atcctttatc agtacggtgc ttttggccat cgtctaggta
    40561 aagaagaaag tgttgaccag ctctttaaga atcgtcgtgc gaccgtttcg ctgggctata
    40621 tcggcttgta tgaagtagcg acagttttct ttggtaacag ctgggaaagt aatccagatg
    40681 ctaaggaatt cacgctagac atcattcacg atatgaaacg ccgtgtagaa gagtggtcag
    40741 accaatatgg ctaccatttc tctatctact caacaccatc cgaaagtctg acagaccgtt
    40801 tctgccgact agatatagac aagtttggct ctattcctga tatcacagac aaggaatact
    40861 acaccaactc tttccactac gatgttcgta aaaatccaac accgtttgaa aaattggact
    40921 ttgagaaagt ctatccagaa gcaggtgcgt caggtggttt catccattat tgtgagtatc
    40981 cagtccttca gcaaaatcca aaggccttgg aagctgtctg ggattatgct tatgaccgtg
    41041 taggctatct aggcaccaat actccgattg accgttgcta caagtgtgac tttgaagggg
    41101 attttgaacc aactgagaga gggtttgctt gtccaaactg tggcaatagc gaccctaaaa
    41161 cagtagatgt ggtgaagcga acttgtggct acctaggtaa tcctcaagca agaccgatgg
    41221 tcaacgggcg tcacaaggaa atcgctgcgc gtgtcaaaca tatgaatggt tcaacgatta
    41281 aaatagctgg gcatcaagta acaaattaga aagaaatgaa atgggaaaat atcaacagat
    41341 gtggtgaagc gaacttgtgg ctacctaggt aatcctcaag caagaccgat ggtcaacggg
    41401 cgtcacaagg aaatcgctgc gcgtgtcaaa catatgaatg gttcaacgat taaaatagct
    41461 gggcatcaag taacaaatta gaaagaaatg aaatgggaaa atatcaacta gacgataagg
    41521 ggcgcgcaca agtgacccgt tatcacgaga aacactctaa aggtggagct ggtaaaaaag
    41581 aacgcttgct tagcttcaga gaacaatttt taaacaagaa caagaaaaaa taaaagtgag
    41641 agccagctct cgcttttctc atagtgggag gtaaggatgg aattacgcag accaagatta
    41701 gcggataaga aagctgtttt agatatgatg acagagtttg aaaagagcca atcagcccat
    41761 gatggaggat tttgggatac agagaatttt gtgtatgaag agtggttgga aagcaatcag
    41821 gaacaggaaa tggggattaa tctgcctgaa ggatgggttc ctgcaattca gttagtggct
    41881 ttttctgaga aaggtcaagc agttggattt cttaatctcc ggttgcgcct cagtaacttt
    41941 ctactagaag aaggtgggca cattggctac tccatccgtc catctgaaag aggcaagggt
    42001 tatgcaaaag agactctccg tcagggcttg caagttgcta aggaaaagaa catcaagaaa
    42061 gctctggtga cctgtagcgt gaataatcct gctagcagag cagtcattct agcaaatggt
    42121 ggaatatttg aggatgctca caatggagtc gagcgttatt ggatagaggt agcgaatgaa
    42181 taatccaaaa ccacaagaat ggaaaagcga ggaacttagt caaggtcgta tcattgacta
    42241 caaggccttt aactttgttg atggcgaagg cgtgcgtaac tctctctatg tatcaggctg
    42301 tatgtttcac tgcgagggat gttataatgt tgcgacttgg tcttttaatg ctggcattct
    42361 ctatacagca gaattagaag agcagattat ggcagacctt gcccaaccct atgttcaagg
    42421 cttgactttg ctgggagggg agccttttct taatactggc attctcttgc ctctagttaa
    42481 acgcatccga aaggaattgc cagacaagga catttggtcc tggaccggct acacttggga
    42541 agaaatgatg ttggaaactc cagataaact ggaactctta tcattgattg acattcttgt
    42601 cgatggacga tacgatcgaa ctaagagaaa tctcatgctc cagtttcgag gttcgtccaa
    42661 ccaacgaatt atcgatgtgc aaaaatcgct caaaagtggg caagtagtga tttgggacaa
    42721 gctcaatgac ggaaaagaaa gctatgaaca ggtgaagaga gaatgaagaa aaaagactta
    42781 gtagaccaac tagtctcaga gatcgagacg gggaaagtca ggacactggg aatatacggt
    42841 catggagctt caggtaaatc aacctttgca caggaattgt accaagcttt agattctact
    42901 acagtaaatt tgctagagac agatccttat atcacctcag gacgccatct ggtagtaccc
    42961 aaggacgcgc cgaatcaaaa ggtgacagcc agtctgccag tggcgcatga actggagagt
    43021 ttgcagagag atatccttgc cttgcaggcg ggtatggatg tcttgacaat tgaagaacct
    43081 tggaaggcta gtgaggtctt gtctggagcc aaaccaattt tgattgtcga agggatgtct
    43141 gttggctttc tacccaagga actctttgaa aaaaccatct gtttctacac ggatgaggag
    43201 accgaattaa agcgacgcct tgctagagat acgactgtga gaaatcgcga tgcatccttt
    43261 atattggcta gccatcagat gagacgggag cagtatctgc gatactataa agaaactgag
    43321 tctaaggcgg atatcttagt ggaccaatca gaagataaat ttgatgtcaa gaggacttaa
    43381 cttatgtata gaagaaatat agaagaaaat ccctaatttt agaaagaaaa agtaggaaaa
    43441 cagtttcatc ccaaaaaaac gaaaaaacct aacaaatccc ttgcaatcgc aggggatttg
    43501 tgttattcta ttatggtgct gtaaattaca gccttagttt tgatgcaaga ggttgcgaca
    43561 cgctcggttg cattgccacg caacaccgcg tcggttttct tgtggagcta gcctattatc
    43621 ttaaatagac gaaaaggaga aaaagatggc aaacaaaaaa atccgtatcc gtttgaaagc
    43681 ttacaaacac cgtacgcttg acacagcggc tgcaaaaatc gtagaatcag ctactcgtac
    43741 aggtgcacaa gttgcgggtc caatcccact tccaactgaa cgtagcctct acacaatcat
    43801 tcgtgcgact cacaaataca aagactctcg cgaacaattt gaaatgcgta cacacaaacg
    43861 tttgatcgat atcgttaacc caactcaaaa aacagttgat gccttgatga aattggatct
    43921 tccaagtggt gtaaacgtag aaatcaaact ttaatctaaa atataaaaga gcagaggctg
    43981 gtgtttcaat ctaattgaac acggactaaa ctcggtgtga aaaagataaa cttcctagtg
    44041 tctgctagac actgcgtcag tttcctattt tcactttgag tttgacgccc tttgtatctt
    44101 agacttgagc ataaaaaacg ctcgttaaaa actttttgaa taaaaaatat agaaaaggaa
    44161 ctattttctc atgacaaaag gaatcttagg gaaaaaagtg ggaatgactc aaatcttcac
    44221 tgaagctggc gaattgatcc ctgtaacagt tattgaagca actccaaacg ttgttcttca
    44281 agttaaaact gttgaaacag acggatacaa cgctatccaa gttggtttcg atgacaaacg
    44341 cgaagtattg agcaacaaac ctgctaaagg acatgtagcg aaagctaaca cggctcctaa
    44401 gcgcttcatt cgtgaattca aaaacgttga aggcttggaa gttggtgctg aaattacagt
    44461 tgaaacattc gcagctggag acgttgttga cgtaactggt acttctaaag gtaaaggttt
    44521 ccaaggtgtt atcaaacgcc acggacaatc acgtggacca atggctcacg gttctcgtta
    44581 ccaccgtcgt ccaggttcta tgggacctgt tgcacctaac cgcgtattca aaggtaaaaa
    44641 ccttgcaggg cgtatgggtg gcgaccgcgt aacaattcaa aaccttgaag ttgtacaagt
    44701 tgttccagaa aagaacgtta tccttatcaa aggtaacgta ccaggtgcta agaaatctct
    44761 tatcactatc aaatcagcag ttaaagctgg taaataataa agaaagggga aatcagtcac
    44821 aatggcaaac gtaacattat ttgaccaaac tggtaaagaa gctggccaag ttgttcttag
    44881 cgatgcagta tttggtatcg aaccaaatga atcagttgtg tttgatgtaa tcatcagcca
    44941 acgcgcaagc cttcgtcaag gaacacacgc tgttaaaaac cgctctgcag tatcaggtgg
    45001 tggacgcaaa ccatggcgtc aaaaaggaac tggacgtgct cgtcaaggtt ctatccgctc
    45061 accacaatgg cgtggtggtg gtgttgtctt cggaccaact ccacgttcat acggctacaa
    45121 acttccacaa aaagttcgtc gcctagctct taaatcagtt tactctgaaa aagttgctga
    45181 aaacaaattc gtagctgtag acgctctttc atttacagct ccaaaaactg ctgaatttgc
    45241 aaaagttctt gcagcattga gcatcgattc taaagttctt gttatccttg aagaaggaaa
    45301 tgaattcgca gctctttcag ctcgtaacct tccaaacgtg aaagttgcaa ctgctacaac
    45361 tgcaagtgtt cttgacatcg caaatagcga caaacttctt gtcacacaag cagctatctc
    45421 taaaatcgag gaggttcttg cataatgaat ttgtatgatg ttatcaaaaa acctgtcatc
    45481 actgaaagct caatggctca acttgaagca gggaaatatg tatttgaagt tgacactcgt
    45541 gcacacaaat ttttgatcaa gcaagctgtt gaagctgctt tcgaaggtgt taaagttgcc
    45601 aatgttaaca caatcaacgt aaaaccaaaa gctaaacgtg ttggacgtta cactggtttt
    45661 actaacaaaa ctaaaaaagc tatcatcaca cttacagctg attctaaagc aatcgagttg
    45721 tttgctgctg aagctgaata atctaaggag gaaatatcgt gggaattcgt gtttataaac
    45781 caacaacaaa cggtcgccgt aatatgactt ctttggattt cgctgaaatc acaacaagca
    45841 ctcctgaaaa atcattgctt gttgcattga agagcaaggc tggtcgtaac aacaacggtc
    45901 gtatcacagt tcgtcaccaa ggtggtggac acaaacgttt ctaccgtttg gttgacttca
    45961 aacgtaataa agacaacgtt gaagcagttg ttaaaacaat cgagtacgat ccaaaccgtt
    46021 ctgcaaacat cgctcttgta cactacactg acggtgtgaa agcatacatc atcgctccaa
    46081 aaggtcttga agtaggtcaa cgtatcgttt caggtccaga agcagatatc aaagtcggaa
    46141 acgctcttcc acttgctaac atcccagttg gtactttgat tcacaacatc gagttgaaac
    46201 caggtcgtgg tggtgaattg gtacgtgctg ctggtgcatc tgctcaagta ttgggttctg
    46261 aaggtaaata tgttcttgtt cgtcttcaat caggtgaagt tcgtatgatt cttggaactt
    46321 gccgtgctac agttggtgtt gtcggaaacg aacaacatgg acttgtaaac cttggtaaag
    46381 caggacgtag ccgttggaaa ggtatccgcc caacagttcg tggttctgta atgaacccta
    46441 acgatcaccc acacggtggt ggtgaaggta aagcaccagt tggtcgtaaa gcaccatcta
    46501 ctccatgggg caaacctgct cttggtctta aaactcgtaa caagaaagcg aaatctgaca
    46561 aacttatcgt tcgtcgtcgc aacgagaaat aatattaaac tagtcgctta agcaactagt
    46621 aaatccgcca gctcggtagc gctccatagg agtgcaagcc gctgtggtac aacatttaaa
    46681 ggagaaaata taaaaatggg acgcagtctt aaaaaaggac ctttcgtcga tgagcatttg
    46741 atgaaaaaag ttgaagctca agctaacgac gaaaagaaaa aagttattaa aacttggtca
    46801 cgtcgttcaa cgatcttccc aagtttcatt ggttacacta ttgcagttta tgacggacgt
    46861 aaacacgtac ctgtttacat ccaagaagac atggtaggcc acaaacttgg tgaatttgca
    46921 ccaactcgta cttacaaagg tcacgctgca gacgacaaga aaacacgtag aaaataagga
    46981 gaacataaat ggcagaaatt acttcagcta aagcaatggc tcgtacagta cgtgtttcac
    47041 ctcgtaaatc acgtcttgtt cttgataaca tccgtggtaa aagcgtagcc gatgcaatcg
    47101 caatcttgac attcactcca aacaaagctg ctgaaatcat cttgaaagtt ttgaactcag
    47161 ctgtagctaa cgctgaaaac aactttggtt tggataaagc taacttggta gtatctgaag
    47221 cattcgcaaa cgaaggacca actatgaaac gtttccgtcc acgtgcgaaa ggttcagctt
    47281 caccaatcaa caaacgtaca gctcacatca ctgtagctgt tgcagaaaaa taaggaggta
    47341 aaatcgtggg tcaaaaagta catccaattg gtatgcgtgt cggcatcatc cgtgattggg
    47401 atgccaaatg gtatgctgaa aaagaatacg cggattacct tcatgaagat cttgcaatcc
    47461 gtaaattcgt tcaaaaagaa cttgctgacg cagcagtttc aactattgaa atcgaacgcg
    47521 cagtaaacaa agttaacgtt tcacttcaca ctgctaaacc aggtatggtt atcggtaaag
    47581 gtggtgctaa cgttgatgca ctccgtgcaa aacttaacaa attgactgga aaacaagtac
    47641 acatcaacat catcgaaatc aaacaacctg atttggatgc tcaccttgta ggtgaaggaa
    47701 ttgctcgtca attggagcaa cgtgttgctt tccgtcgtgc acaaaaacaa gcaatccaac
    47761 gtgcaatgcg tgctggagct aaaggaatca aaactcaagt atcaggtcgt ttgaacggtg
    47821 cagatatcgc ccgtgctgaa ggatactctg aaggaactgt tccgcttcac acacttcgtg
    47881 cagatatcga ttacgcttgg gaagaagcag atactacata cggtaaactt ggtgttaaag
    47941 tatggatcta ccgtggtgaa gttcttccag ctcgtaaaaa cactaaagga ggtaaataac
    48001 caatgttagt acctaaacgt gttaaacacc gtcgtgagtt ccgtggaaaa atgcgcggtg
    48061 aagcaaaagg tggaaaagaa gtagcattcg gtgaatacgg tcttcaagct acaactagcc
    48121 actggatcac taaccgccaa atcgaagctg ctcgtatcgc catgactcgt tacatgaaac
    48181 gtggtggtaa agtttggatt aaaatcttcc cacacaaatc atacactgct aaagctatcg
    48241 gtgtgcgtat gggatctggt aaaggggcac ctgaaggttg ggtagcacca gttaaacgtg
    48301 gtaaagtgat gttcgaaatc gctggtgtat ctgaagagat tgcacgtgaa gcgcttcgac
    48361 ttgctagcca caaattgcca gttaaatgta aattcgtaaa acgtgaagca gaataaggag
    48421 aaggcatgaa acttaatgaa gtaaaagaat ttgttaaaga acttcgtggt ctttctcaag
    48481 aagaactcgc gaagcgcgaa aacgaattga aaaaagaatt gtttgaactt cgtttccaag
    48541 ctgctactgg tcaattggaa caaacagctc gcttgaaaga agttaaaaaa caaatcgctc
    48601 gtatcaaaac agttcaatct gaagcgaaat aatagactag ggaaggagaa atttcaatgg
    48661 aacgcaataa tcgtaaagtt cttgttggac gtgttgtatc tgacaaaatg gacaagacaa
    48721 tcacagttgt agttgaaaca aaacgtaacc acccagtcta tggtaaacgt attaactact
    48781 ctaaaaaata caaagctcat gatgaaaaca atgttgccaa agaaggcgat atcgtacgta
    48841 tcatggaaac tcgcccgctt tcagctacaa aacgtttccg tcttgtagaa gttgttgaag
    48901 aagcggtcat catctaatca aacctgaaag gagaaaactg aaatgattca aacagaaact
    48961 cgtttgaaag tcgcagacaa cagcggtgct cgcgaaatct tgactatcaa agttcttggt
    49021 ggttcaggac gtaaatttgc aaacatcggt gatgttatcg tggcatctgt aaaacaagct
    49081 actcctggtg gtgcggttaa aaaaggtgac gttgttaaag cagttatcgt tcgtactaaa
    49141 tcaggtgctc gtcgtgctga tggttcatac atcaaatttg acgaaaacgc agcagttatc
    49201 atccgtgaag acaaaactcc tcgcggaaca cgtatctttg gcccagttgc acgtgaattg
    49261 cgtgaaggtg gcttcatgaa gatcgtgtca cttgctccag aagtacttta atttttagga
    49321 acaaactagt cccctagctt caagctaggg tgcccttatg ggcgtaagaa aaatcaagga
    49381 gaaacctaat gtttgtaaaa aaaggcgaca aagttcgcgt aatcgctggt aaagataagg
    49441 gaacagaagc tgttgtcctt actgcccttc caaaagtaaa caaagttatc gttgaaggtg
    49501 ttaacattgt taagaaacac caacgtccaa ctaacgagct tcctcaaggt ggtatcatcg
    49561 agaaagaagc agctatccac gtatcaaacg ttcaagtttt ggacaaaaat ggtgtagctg
    49621 gtcgtgttgg atacaaattt gtagacggta aaaaagttcg ctacaacaaa aaatcaggcg
    49681 aagtgcttga ttaatcacga aggaaaggag aagtataatg gcaaatcgtt taaaagaaaa
    49741 atatcttaat gaagtagttc ctgctttgac agaacaattc aactactcat cagtgatggc
    49801 tgtgcctaaa gtagataaga ttgttttgaa catgggtgtt ggtgaagctg tatcaaacgc
    49861 taaaagcctt gaaaaagctg ctgaagaatt ggcacttatc tcaggtcaaa aaccacttat
    49921 cactaaagct aaaaaatcaa tcgccggctt ccgtcttcgt gaaggtgttg cgatcggtgc
    49981 aaaagttacc cttcgtggtg aacgtatgta cgaattcttg gataaattgg tatcagtttc
    50041 acttccgcgt gtacgtgact tccacggtgt tccaacaaaa tcatttgatg gacgcgggaa
    50101 ctacacactt ggtgtgaaag aacaattaat cttcccagaa attaacttcg atgacgttga
    50161 caaaactcgt ggtcttgaca tcgttatcgt aacaactgct aacactgacg aagagtcacg
    50221 tgcattgctt acaggccttg gaatgccttt tgcaaaataa tataggaggt aaatctaatg
    50281 gctaaaaaat caatggtagc tagagaggct aaacgccaaa aaattgttga ccgttatgct
    50341 gaaaaacgtg ctgcattaaa ggcggcaggg gactacgaag gtttatctaa attacctcgc
    50401 aacgcctcac cgactcgttt acataatcgt tgtagagtta cggggcgccc acattcagtt
    50461 taccgcaaat ttggtctgag tcgtatcgct tttcgcgaac ttgcgcataa aggtcaaatt
    50521 cctggtgtaa caaaagcatc ttggtaattt aagatatcaa gagcgtcaaa actccaagta
    50581 aaaataggaa acttgacgaa gaaactaaag tttctaggaa agtttatctt tttcacacag
    50641 agtttagccc gggttcaatt gggcttgcca atttgaacac gagctacagc tttggcaaaa
    50701 aagaccaatt tgctttggag cattgcttct gcattaaatt gtctattttt gctcgtgctg
    50761 ttacgctctt tgtatcatgt attaactagc aagtgcaact tgcaaactac tagtaagagg
    50821 agaaaaacaa aatggttatg actgacccaa tcgcagactt cctaactcgt attcgtaatg
    50881 ctaaccaagc taaacacgaa gtacttgaag tacctgcatc aaacatcaaa aaagggattg
    50941 ctgaaatcct taaacgcgaa ggttttgtaa aaaacgttga aatcattgaa gatgacaaac
    51001 aaggcgtcat ccgtgtattt cttaaatacg gaccaaatgg tgagaaagtt atcactaact
    51061 tgaaacgtgt ttctaaacca ggacttcgtg tctacaaaaa acgtgaagac cttccaaaag
    51121 ttcttaacgg acttggaatt gccatccttt caacttctga aggtttgctt actgataaag
    51181 aagcacgcca aaagaatgtt ggtggtgagg ttatcgctta cgtttggtaa aatcaagata
    51241 caaagctcgt aaagaacaaa gcaaaattag gaagttggag aagtttgttt acaaacaagc
    51301 caacttatct attttgcaca gttcttagag cgtgttcagt tcagctcttg aactaaataa
    51361 gtatctgaac cccgtgaaaa ctggccgttt tggcctgaca atttaacagg agaaaataaa
    51421 catgtcacgt attggtaata aagttatcgt gttgcctgct ggtgttgaac tcgctaacaa
    51481 tgacaacgtt gtaactgtaa aaggacctaa aggagaactt actcgtgagt tctcaaaaga
    51541 tattgaaatc cgtgtggaag gtactgaagt aactcttcac cgtccaaacg attcaaaaga
    51601 aatgaaaact atccacggaa ctactcgtgc ccttttgaac aacatggttg ttggtgtatc
    51661 agaaggattc aagaaagaac ttgaaatgcg tggggttggt taccgtgcac agcttcaagg
    51721 atctaaactt gttttggctg ttggtaaatc tcatccagac gaagttgaag ctccagaagg
    51781 aattactttt gaacttccaa acccaacaac aatcgttgtt agcggaattt caaaagaagt
    51841 agttggtcaa acagctgctt acgtacgtag ccttcgttca ccagaaccat ataaaggtaa
    51901 aggtatccgt tacgttggtg aattcgttcg ccgtaaagaa ggtaaaacag gtaaataatg
    51961 ttgagtggtt gatcatcaac caccaaccta ttttccaact ttgtgcatag cacacgattt
    52021 aaaactaaag aggtgaaaac tgtgatttca aaaccagata aaaacaaact ccgccaaaaa
    52081 cgccaccgtc gcgttcgcgg aaaactctct ggaactgctg atcgcccacg tttgaacgta
    52141 ttccgttcta atacaggcat ctacgctcaa gtgattgatg acgtagcggg tgtaacgctc
    52201 gcaagtgctt caactcttga taaagaagtt tcaaaaggaa ctaaaactga acaagccgtt
    52261 gctgtcggta aactcgttgc agaacgtgca aacgctaaag gtatttcaga agtggtgttc
    52321 gaccgcggtg gatatctata tcacggacgt gtgaaagctt tggctgatgc agctcgtgaa
    52381 aacggattga aattctaata ggaggacact agaaaatggc atttaaagac aatgcagttg
    52441 aattagaaga acgcgtagtt gctgtcaacc gtgttacaaa agttgttaaa ggtggacgtc
    52501 gtcttcgttt cgcagctctt gttgttgttg gtgaccacaa tggtcgcgta ggatttggta
    52561 ctggtaaagc tcaagaagtt ccagaagcaa tccgtaaagc agtagatgat gctaagaaaa
    52621 acttgatcga agttcctatg gttggaacaa caatcccaca cgaagttctt tcagaattcg
    52681 gtggagctaa agtattgttg aaacctgctg tagaaggttc tggagttgcc gctggtggtg
    52741 cagttcgtgc cgttgtggaa ttggcaggtg tggcagatat tacatctaaa tcacttggtt
    52801 ctaacactcc aatcaacatt gttcgtgcaa ctgttgaagg tttgaaacaa ttgaaacgcg
    52861 ctgaagaaat tgctgccctt cgtggtattt cagtttctga tttggcataa gaaaggggat
    52921 aaaatggctc aaattaaaat tactttgact aagtctccaa tcggacgcat tccatcacaa
    52981 cgtaaaactg ttgtagcact tggacttggc aaattgaaca gctctgttat taaagaagat
    53041 aacgctgcta tccgtggtat gatcacagca gtatctcact tagtaacagt tgaagaagta
    53101 aactaatgaa gttttagggg atgtgcactg taccatcccc taaaactaga tatagtcatc
    53161 tatgatgaca tcgtataggc gagttgatgg gggagacaac cttttctccc ttatcggcgc
    53221 tagcatttta caaaagagga gaaaataaaa atgaaacttc atgaattgaa acctgcagaa
    53281 ggttctcgta aagtacgtaa ccgcgttggt cgtggtactt catcaggtaa cggtaaaaca
    53341 tctggtcgtg gtcaaaaagg tcaaaaagct cgtagcggtg gcggagttcg ccttggtttt
    53401 gaaggtggac aaactccatt gttccgtcgt cttccaaaac gtggattcac taacatcaac
    53461 gctaaagaat acgcaattgt gaaccttgac caattgaacg tctttgaaga tggtgctgaa
    53521 gtaactccag ttgttcttat cgaagcagga attgttaaag ctgaaaagtc aggtattaaa
    53581 attcttggta acggtgagtt gactaagaaa ttgactgtga aagcagctaa attctctaaa
    53641 tcagctgaag aagctatcac tgctaaaggt ggttcagtag aagtcatcta agagaggtga
    53701 cctatgtttt ttaaattatt aagagaagct cttaaagtca agcaggttcg atcaaaaatt
    53761 ttatttacaa tttttatcgt tttggtcttt cgtatcggaa ctagcattac agttcctggt
    53821 gtgaatgcca atagcttgaa tgctttaagt ggattatcct tcttaaacat gttgagcttg
    53881 gtgtcgggga atgccctaaa aaacttttcg atttttgccc taggagttag tccctatatc
    53941 accgcttcta ttgttgtcca actcttgcaa atggatattt tacccaagtt tgtagagtgg
    54001 ggtaaacaag gggaagtagg tcgaagaaaa ttgaatcaag ctactcgtta tattgctcta
    54061 gttctcgctt ttgtgcaatc tatcgggatt acagctggtt ttaatacctt ggctggagct
    54121 caattgatta aaactgcttt aactccacaa gtttttctga cgattggtat catcttaaca
    54181 gctggtagta tgattgtcac ttggttgggt gagcaaatta cagataaggg atacggaaac
    54241 ggtgtttcca tgattatctt tgccgggatt gtttcctcaa ttccagagat gattcagggc
    54301 atctatgtgg actactttgt gaacgtccca agtagccgta tcacttcatc tatcattttc
    54361 gtaatcattt tgattattac tgtattgttg attatttact ttacaactta tgttcaacaa
    54421 gcagaataca aaattccaat ccaatatact aaggttgcac aaggtgctcc atctagctct
    54481 taccttccgt taaaggtaaa tcctgctgga gttatccctg ttatctttgc cagttcgatt
    54541 actgcagcgc ctgcggctat tcttcagttt ttgagtgcca caggtcatga ttgggcttgg
    54601 gtaagggtag cacaagagat gttggcaact acttctccaa ctggtattgc catgtatgct
    54661 ttgttgatta ttctctttac attcttctat acgtttgtac agattaatcc tgaaaaagca
    54721 gcagagagcc tacaaaagag tggtgcctat atccatggag ttcgtcctgg taaaggtaca
    54781 gaagaatata tgtctaaact tcttcgtcgt cttgcaactg ttggttccct cttccttggt
    54841 gtgatttcca ttttaccgat tgcagctaaa gatgtatttg gtctttctga tgttgttgcc
    54901 tttggtggaa caagtctctt gatcattatc tctacaggta tcgaaggaat caagcaattg
    54961 gaaggttacc tattgaaacg taagtatgtt ggtttcatgg acagaacaga ataaaagtat
    55021 ttactgaatc agtaaatact gagggagtgg aggtttaaac tctgacattt gtaagagttg
    55081 gatctcccct cttctatttt gtttttaaat cggggtgaaa aaactttttg cttctattta
    55141 aaaacaaaat aaggagatca aattatgaat cttttgatta tgggcttacc tggtgcaggt
    55201 aagggaactc aagcagcaaa aatcgtagaa caattccatg ttgcacatat ctcaacaggt
    55261 gatatgttcc gcgctgcaat ggcaaatcaa actgaaatgg gtgttcttgc taagtcatat
    55321 attgacaagg gtgaattggt tcctgacgaa gttacaaatg gaatcgtaaa agaacgcctt
    55381 tcacaagatg atattaaaga aacaggattc ttattggatg gttacccacg tacaattgaa
    55441 caagctcatg ccttggacaa aacattggct gaacttggca ttgaactaga aggtattatc
    55501 aatattgaag ttaaccctga cagcctcttg gaacgtttga gtggccgtat catccaccgc
    55561 gtaactggag aaactttcca caaggtcttt aacccaccag ttgactataa agaagaagat
    55621 tactaccaac gtgaagatga taagcctgag acagtaaaac gtcgtttgga tgttaatatt
    55681 gctcaaggag aaccaatcat tgctcactac cgtgccaaag gtttggttca tgacatcgaa
    55741 ggtaatcaag atatcaatga tgtcttctca gatattgaaa aagtattgac aaatttgaaa
    55801 taaagcgttt ttcacacttg caaaaatccg ctacaaatgt tatactgaaa tagtctgact
    55861 tataattgtt gtctctgtgt ctagaggcat cgaatcgaaa tttatggagg tgcttttgcg
    55921 tggcaaaaga cgatgtgatt gaagttgaag gcaaagtagt tgatacaatg ccgaatgcaa
    55981 tgtttacggt tgaacttgaa aatggacatc agattttagc aacagtttct ggtaaaattc
    56041 gtaaaaacta tattcgtatt ttagcgggag atcgtgttac tgtcgaaatg agtccatatg
    56101 acttgacacg tggacgtatc acttaccgct ttaaataatc gaaaaacttg gagggataag
    56161 aaatgaaagt aagaccatcg gtcaaaccaa tttgcgaata ctgtaaagtt attcgtcgta
    56221 atggtcgtgt tatggtaatt tgcccagcaa atccaaaaca caaacaacgt caaggataag
    56281 atagaaagga gaaaacatgg ctcgtattgc tggagttgat attccaaatg acaaacgcgt
    56341 agtaatctca ttgacttatg tttatggtat cggacttgca acatctaaga aaattttggc
    56401 tgctgctgga atctcagaag atgttcgtgt acgtgatctt acatcagatc aagaagatgc
    56461 tatccgtcgt gaagtggatg caatcaaagt tgaaggtgac cttcgtcgtg aagtaaactt
    56521 gaacatcaaa cgtttgatgg aaatcggttc ataccgtggt atccgtcacc gtcgtggact
    56581 tcctgtccgt ggacaaaata ctaaaaacaa cgctcgcact cgtaaaggta aagctgttgc
    56641 gattgctggt aagaaaaaat aatataggag gtaaaagtct tggctaaacc aacacgtaaa
    56701 cgtcgtgtga aaaagaatat cgaatctggt attgctcata ttcacgctac atttaataac
    56761 actattgtta tgattactga tgtgcatggt aatgcaattg cttggtcatc agctggtgct
    56821 cttggtttca aaggttctcg taaatctaca ccattcgctg ctcaaatggc ttctgaagct
    56881 gctgctaaat ctgcacaaga acacggtctt aaatcagttg aagttactgt aaaaggtcca
    56941 ggttctggtc gtgagtcagc tattcgtgcg cttgctgccg ctggtcttga agtaacagca
    57001 attcgtgatg tgactccagt gccacacaat ggtgctcgtc ctccaaaacg tcgccgtgta
    57061 taatcatcgc attacactgc ttttcgttta agagggagta actaaatgat cgagtttgaa
    57121 aaaccaaata taacaaaaat tgatgaaaat aaagattatg gcaagtttgt aatcgaacca
    57181 cttgaacgtg gctacggtac aactcttggt aactctcttc gtcgtgtact tctagcttct
    57241 ctaccaggag cagctgtgac atctatcaac attgatggtg tgttacatga gtttgacaca
    57301 gttccaggtg ttcgtgaaga cgtgatgcaa atcattctga acattaaggg aattgcagtg
    57361 aaatcgtacg ttgaagacga aaaaatcatc gaactggatg ttgaaggtcc tgctgaagta
    57421 acagctggtg acattttgac agatagcgat attgaaattg taaatccaga tcattatctc
    57481 tttacaatcg gtgaaggttc ttctctaaaa gcgactatga ctgttaacag tggtcgtgga
    57541 tatgtacctg ctgacgaaaa taaaaaggat aatgcaccag ttggaacact tgctgtagat
    57601 tctatttata caccagttac aaaagtcaac tatcaagtgg aacctgctcg tgtaggtagc
    57661 aatgatggtt tcgacaaatt aacccttgaa atcttgacaa atggaacaat tattccagaa
    57721 gatgctttag ggctttcagc acgtattttg acagaacatc ttgatttgtt tacaaatctt
    57781 actgagattg ctaagtcaac tgaagtgatg aaagaagctg atactgaatc tgacgaccgt
    57841 attttagatc gtacgattga ggaactggac ttgtctgtgc gttcatacaa ctgtttaaaa
    57901 cgtgccggta tcaatactgt gcatgatttg acagaaaaat ctgaagcaga gatgatgaaa
    57961 gtacgaaatc ttggacgcaa gagtttggaa gaagtgaaac tcaaactcat tgatttgggt
    58021 cttggattaa aagataaata aaggaggaat acatggctta ccgtaaacta ggacgcacta
    58081 gctcacaacg taaagcaatg cttcgcgatt tgacaactga ccttttgatc aacgaatcaa
    58141 tcgtgacaac tgaagctcgt gctaaagaaa tccgtaaaac tgttgaaaaa atgattactc
    58201 taggtaaacg tggtgatttg catgcacgtc gtcaagcagc tgctttcgta cgtaatgaaa
    58261 tcgcatctga aaactatgat gaagcaactg ataagtacac ttctactaca gcacttcaaa
    58321 aattgttctc agaaatcgca cctcgttatg ctgaacgtaa cggtggatac actcgtatcc
    58381 ttaaaactga accacgtcgt ggtgatgcag cgccaatggc gatcatcgaa ttagtataaa
    58441 atcatcaatt ttgttgagtg ttatgatgat ggagtcttgt gctcttagtc tagctctggt
    58501 ctaccgctag gatttcggtc ctagcgggaa cactcatcat aagttgggat agtagacgct
    58561 tgtttacgaa attgtttttt tcttaagaac aacttcgtaa gcaggcgttt ttgagtattt
    58621 tcgttagaat tatgctatac tatttgaaaa gaatcctgtt taatgttaag gtttcttatt
    58681 ttaagaagaa ttggagttta cttatgaaag ccattataac tgttgttggt aaagataaat
    58741 ctggaattgt tgcaggtgtt tctggtaaaa ttgcagaatt aggattgaat attgacgata
    58801 tctctcaaac tgtattggat gaatatttta cgatgatggc tgttgtatct agtgatgaaa
    58861 agcaagattt tacctatctt cgtaatgaat ttgaagcttt tgggcaaact ttgaatgtaa
    58921 aaatcaatat tcagagtgca gcgattttcg aagctatgta taatatctag gaggtcatca
    58981 tggatattag acaagttact gaaaccatcg ccatgattga ggagcaaaac ttcgatatta
    59041 gaaccattac catggggatt tctcttttgg actgtatcga tccaaatatc aatcgtgctg
    59101 cggagaaaat ctatcaaaaa attacgacaa aggcggctaa tttagtagct gttggtgatg
    59161 aaattgcggc tgagttggga attcctatcg ttaataagcg tgtatcggtg acacctattt
    59221 ctctgattgg ggcagcgaca gatgcgacgg actacgtggt tctggcaaaa gcgcttgata
    59281 aggctgcgaa agagattggt gtggacttta ttggtggttt ttctgcctta gtacaaaaag
    59341 gttatcaaaa gggagatgag attctcatca attccattcc tcgcgctttg gctgagacgg
    59401 ataaggtctg ctcgtcagtc aatatcggct caaccaagtc tggtattaat atgacggctg
    59461 tggcagatat gggacgaatt atcaaggaaa cagcaaatct ttcagatatg ggagtggcca
    59521 agttggttgt attcgctaat gctgttgagg acaatccatt tatggcgggt gcctttcatg
    59581 gtgttgggga agcagatgtt atcatcaatg tcggagtttc tggtcctggt gtggtgaaac
    59641 gtgctttgga aaaagttcgt ggacagagct ttgatgtagt agccgaaaca gttaagaaaa
    59701 ctgcctttaa aatcactcgt atcggtcaat tggttggtca aatggccagt gagagactgg
    59761 gtgtggagtt tggtattgtg gacttgagtt tggcaccaac ccctgcggtt ggagactctg
    59821 tagcacgtgt ccttgaggaa atggggctag aaacagttgg cacgcatgga acgacggctg
    59881 ccttggccct cttgaacgac caagttaaaa agggtggagt gatggcctgc aaccaagtcg
    59941 gtggtttatc tggtgccttt atccctgttt ctgaggatga aggaatgatt gctgcagtgc
    60001 aaaatggctc tcttaattta gaaaaactag aagctatgac ggctatctgt tctgttggat
    60061 tggatatgat tgccatccca gaagatacgc ctgctgaaac cattgcggct atgattgcgg
    60121 atgaagcagc aatcggtgtt atcaacatga aaacaacagc tgttcgtatc attcccaaag
    60181 gaagagaagg cgatatgatt gagtttggtg gtctattagg aactgcacct gttatgaagg
    60241 ttaatggggc ttcgtctgtc gacttcatct ctcgcggtgg acaaatccca gcaccaattc
    60301 atagttttaa aaattaagaa aataggagaa attttaagtt ctatttaaga ttagacgtgt
    60361 atactataat cattaaataa agacctccta atattatttg aaacagataa cactgaatta
    60421 gtttgaattt gattttcatc taatatcttt atttaatgaa ctcctaaact ttttcataat
    60481 aatctccttc aaaagtcgcc tgtatgggtg gcttttattt tatcattcat gatataatag
    60541 aagcaaacgg aggacggaaa atggtaaaag tacgattgta tttggtacgt catggcaaga
    60601 ccatgtttaa cacgattggt cgcgcgcaag gttggagcga tactccctta actgctgaag
    60661 gtgaacgagg gattcaagag ttaggaatcg gtttgcgaga atctgatcta cagtttgagc
    60721 gcgcttattc gagtgattct ggtcgtacca ttcagaccat gggaattatc cttgaagaac
    60781 ttggcttgca ggggaaaatc ccttatcgca tggacaagcg tatcagagaa tggtgtttcg
    60841 gtagttttga tggagcctat gatggcgatc ttttcatggg cattattcct cgtatcttta
    60901 atgtggacca cgttcaccaa ttgtcttatg ctgaactggc tgagggcttg gtagaggtcg
    60961 atacagctgg ttgggctgaa ggctgggaaa aactcagtgg ccgaatcaag gaaggctttg
    61021 aaatgattgc aaaagaaatg gaagatcaag gtggaggtaa cgcccttgtt gtcagccatg
    61081 gaatgactat tggaaccatt gtttatctga ttaatggcat gcatccgcat ggtctagata
    61141 atggtagcgt gacgattctt gaatatgagg acggtcagtt tagggttgaa gttgtcggtg
    61201 accgtagtta ccgagagcta ggacgtgaga agatggaaga aggctctatt taatcagtct
    61261 agacttgctt gccatgagct agggatttga taagaatatc aagataagaa aaaacagccg
    61321 agggtactcc tttcggctgt ttttgatgtg gaaaactaaa gtgtaatgct attgctttta
    61381 gagattttca taaacaagag caaggaacct actgttagaa cagtcaggat agttgacaag
    61441 gctgcggcta caccgtaatt tcctctgaga acctctgtat aaatagctac agtcattgtt
    61501 cttgttttga cattgtagag gaggatagaa gtagagagtt ttgaaatcat tgtgacccaa
    61561 gataagatgg ctccagaaat gataccagat agcatcattg gagttgtaat cttagcaaag
    61621 gtattgagac gactacttcc taagctttca gcagcttctt caatacttgg tgctatttgt
    61681 tgtaagctag caacagatga gcgaatagta tacggtaatc ttctgacaga tagagacata
    61741 atcaagatga aagcagtccc tgtaatcata agaaatccac ttccaaatag accagtattg
    61801 aaggaagaaa tgaaggcaat ccctagaacg gttcctggta caatataagg taccatactg
    61861 aggctgtcaa ttaagtttgt aaacaaattc cgttttctaa cggctaggta ggagataaat
    61921 gtcgcaaata gaacaactag aactaaggca atcaaaggga tacgaatggt attgaaaata
    61981 gcagctccca tacgattgaa agctagcttg taactgtttg gagaataacc tttaaaaaat
    62041 accatacctg atgtttttag gaaagaggta taaattaagt agatttgagg taaaacagag
    62101 ataaagataa ttccgtagac tgttgcataa atggcagtca tttttccttt tgtagttttt
    62161 ttaggctcaa ttggatggag cagattcatg ctgaaactgt agcggtttgc aatgtgtttt
    62221 tggataagga aaattgccaa ggcaatgata atcgccataa ttgcaaaagc agaatttcct
    62281 ccaacctcgc taataaattg ggtataaatc aggacaggga aagtccgata tccttcgcca
    62341 atcaacatag gcgttccaaa gtctgagaat gctctcataa atacaagcaa ggagctgcta
    62401 gtaaggttgg aactaggaga ggtaaaacaa ccgttacgat aggtttaaat ccgaaggacc
    62461 ccatgctttc agctgcttca agtagagaat tgtcaatact gttcattgtt ccagcaacat
    62521 atagaaatac cagtgggaat agttgcagtg taaagacaag tataattcct ttgaatccat
    62581 aaatatcgat agctggaaga taaagggcat ttgtcaaaaa tttagtgatg acctcatttc
    62641 gtcccagcaa gagaatccag gagtaggctc ctacgaaagg agctgacatg gaagcaatga
    62701 taatcaatat ttgtagaaat ttcttcccct tgaagtcata catagagaag agataagcta
    62761 atagggttcc tacaactaag gaagtgacag tagcggtaat ggaaaccctg aaactgttga
    62821 ctagtgtctc agagtagtag gctttactaa agaaagtgac aaaattagct agtgagaatt
    62881 atccttcatg tataagtgct tacttgagca cggtaacgat aggataaacg agaaagacaa
    62941 gataggtaag aaagatgaag aaagaggagg ctgtccaaat atttagtttt ttacgttcca
    63001 tggttgactc cttttatcag gttttgggaa ccatctgcag aaaagatgtt taatttttgc
    63061 gtattgattc gtagacgaat acgattgcct ttttgtagtt cttcttcaaa agttgattct
    63121 tcactaactt gaatttttga ggcaaaacct gtctcaatga aatactccgt atttagtcca
    63181 agatagacgc tatcgctaat agttccttca atatctccag attcatcttt gataaactct
    63241 tcgggacgaa tgcttacatg aatagcttgc tcctcaacct gatcaagagc tagcattcga
    63301 agggcatagc catctgaaaa gacgatataa gcgccgtcgc tccgtttttc aagattggca
    63361 gggataatat ttgtgcgtcc gataaaggtt gccacaaact cattagctgg tttatgatag
    63421 agttcttttg gtcggccgat ttgttggatc accccatctt tcataacagc aatttggtct
    63481 gaaatagcca tggcttcttc ttggtcgtgg gttacataaa cagttgtaat tcccacttcg
    63541 tgttggattt ctcggatggc ttgacgcata tccaagcgaa gtttggcctc cagattacta
    63601 agtggctcgt ccatgaggag aacacttgga ttaaccgcta aggcgcatgc caaggtgaca
    63661 cgttgttgtt gtccaccact gagtttatcg ggctttcgat ccgcatattg agcaatttgc
    63721 atgagtccaa gatacttgtt ggtctgttga atcaattctt cttttggaac cttcttttgc
    63781 ataagaccaa aagcaacgtt gtctcggaca gtcaaatgtg ggaaaatagc gtagttttgg
    63841 aaaaccagcc cgatattgcg tttgctgggt tccatattat tgatttttgt atcatcgaag
    63901 taaaattctc catctttgat actgttgaaa cctgcaatca tacgaagaag ggtcgttttc
    63961 ccacatcctg aagctccaag aagggtaaag agacttcctt ttggaattgt aatgttcaaa
    64021 ttctcaataa cagggacatc gtggtagatt tttttggcgt taataatttc gatctcactc
    64081 atagtgaacc tcttttactg tttagattgg atatctgtaa agacttcgtt gtatttctta
    64141 acgatatctg atttattctt gatgacataa tcataatctt cagtgagtgt tttgattttg
    64201 tcaattggtt tcatgttttc gcttgtttta gcatttttac gaacaggacg gttagtagtg
    64261 gttgtaccaa gtgtatcttg tacttcttga gagataataa aatcgataaa tttcttggca
    64321 ttttccatat ttttagattt tttaacgata gcagcactag caggtaggaa gacggttcct
    64381 tcttttggat agactacctt aatgttagct ccgtcattta agagtttaac tgctggatct
    64441 ttataagaga gaccaacagt catttctcca tcagcgactg ctttatagac accagatgaa
    64501 cttaaaccga ttttatagta tattgaaact agaatagtac acatctactt ctaaaacatt
    64561 gttagaaatc gatttgactg tcctgattaa tttgtcctgt tcttatttca ttttactata
    64621 ccatcaataa gtgtgaaaag atcttttaca taagaccaag ccttatcatc tttgtaacca
    64681 ccttgagctt gtagcatatt tgttaattga gcaaaggcgc tagaagagtt tgctgggtca
    64741 gcagttgcga tttttccttt tagttcaggt ttgagaaggt cgctatatcc ttcgatgttc
    64801 atgcctttag ttaaatcagg gtggacgatt aaaacactac catctagtgt ataaggagta
    64861 gagaagccag ttgtgttttg atattctttg ataacattat cattttcttt tgaaatatag
    64921 ttttcaaaga gttctccgtg ggtagcatat tgtgtataag aaccaccaaa gataacatca
    64981 gctacaggaa cttctttttc tgactctagt tttttgaaaa gttctccagt accagcttga
    65041 atcagttcta ttttgatacc atatttttct tcaaaggcag gaatagttgc tccaattaag
    65101 ccctctgagt ttggtcaata aacgactagc gaaccaccgt ctcctttatc agatgaactg
    65161 tcatcggcag attcattaga agaacaagca gcataataca tccatttctt tttcatgatg
    65221 gatacctccg ttgtgttatt taagtttatt ttaaaacaat gtaagcgttt ttaaaaccta
    65281 caattctatt ctatagtgta ttgaatctat aacagtacac
//
LOCUS       DAVHIZ010000004        55831 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.004, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000004 DAVHIZ010000000
VERSION     DAVHIZ010000004.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 55831)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 55831)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..55831
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.004"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            446..1921
                     /locus_tag="VVO18_000257"
     CDS             446..1921
                     /locus_tag="VVO18_000257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000661022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="HEU5585479.1"
                     /translation="MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELL
                     GEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILA
                     TCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDH
                     PDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMAAG
                     ADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRN
                     LALRGKESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIG
                     LTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGK
                     DLIAGEYIQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERIT
                     REIVDYIQFAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ"
     gene            complement(1887..2602)
                     /locus_tag="VVO18_000258"
                     /pseudo
     CDS             complement(1887..2602)
                     /locus_tag="VVO18_000258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809094.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS110 family transposase"
     gene            2689..2826
                     /locus_tag="VVO18_000259"
     CDS             2689..2826
                     /locus_tag="VVO18_000259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001270407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585480.1"
                     /translation="MRYQTHYQLKQKLWLEPFGNRQAIGGNELIHSGLFQVYHLGFGS
                     S"
     gene            2857..3717
                     /gene="speE"
                     /locus_tag="VVO18_000260"
     CDS             2857..3717
                     /gene="speE"
                     /locus_tag="VVO18_000260"
                     /EC_number="2.5.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyamine aminopropyltransferase"
                     /protein_id="HEU5585481.1"
                     /translation="MDLWFSEVHTPDVKLSLRTAKQLYAGKSEWQDIEVLDTPAFGKI
                     LILNGHVLFSDADDFVYNEMTVHVPMAVHPNPKKVLVIGGGDGGVAQVLTLYPELEQI
                     DIVEPDEMLVEVCREYFPDFAAGLDDPRVTIYYQNGLRFLRNCEDDYDIIINDATDPF
                     GHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESACRSMHRKVNQAFPISRVY
                     QAHIPTSPAGYWLFGFASKKYHPVKDFDKEGWKKRQLFTEYYTANLHVGAFMLPKYVE
                     DILEEEEGKK"
     gene            3714..4973
                     /locus_tag="VVO18_000261"
     CDS             3714..4973
                     /locus_tag="VVO18_000261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000088792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="saccharopine dehydrogenase family protein"
                     /protein_id="HEU5585482.1"
                     /translation="MSRLLVIGCGGVAQVAISKICQDSETFTEIMIASRTKSKCDDLK
                     AKLEGKTSTKIETAALDADKVEEVITLIESYKPEAVLNVALPYQDLTIMDACLATGVH
                     YIDTANYEAEDTEDPEWRAIYEKRCKELGFTAYFDYSWQWAYQEKFKEAGLTALLGSG
                     FDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYW
                     EDGKWVEVEAMSIKREYDFPQVGQKDMYLLHHEEIESLAKNIPGVKRIRFFMTFGQSY
                     LTHMKCLENVGLLRTDTINFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGV
                     KDGVEKTIYIYNVCDHQECYAEVGSQAISYTTGVPAMIGTKLVMNGTWKQAGVYNLEE
                     LDPDPFMEALNEYGLPWVVVENPQMVD"
     gene            4973..6100
                     /gene="nspC"
                     /locus_tag="VVO18_000262"
     CDS             4973..6100
                     /gene="nspC"
                     /locus_tag="VVO18_000262"
                     /EC_number="4.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxynorspermidine decarboxylase"
                     /protein_id="HEU5585483.1"
                     /translation="MKLEQVPTPAYVIDLAKLEANCRILQYVQEEVGCKVLLAQKAYS
                     LYKTYPLISQYLSGTTASGLYEAKLAREEFPGEVHVFAPAFKDADLEELLGITDHIVF
                     NSERQLRKHGARCREAGVSVGLRLNPQCSTQGDHALYDPCAPGSRFGVTIDKIPSDLL
                     DLVDGLHFHTLCEQGADDLQTTLKAVEEQFGPYLHEVKWLNMGGGHHITREGYDVDLL
                     ISEIKRIRKTYNLEIYIEPGEAIALNAGYLATEVLDIVENGMEILVLDASATCHMPDV
                     LEMPYRPPLRNGFESQEKAHTYRLSSNTCLTGDVIGDYSFENPVQIGDRLYFQDMAIY
                     SFVKNNTFNGIGLPSLYLMDEQGDCSLLKAFGYQDFKGRLS"
     gene            6097..7182
                     /gene="aguA"
                     /locus_tag="VVO18_000263"
     CDS             6097..7182
                     /gene="aguA"
                     /locus_tag="VVO18_000263"
                     /EC_number="3.5.3.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="agmatine deiminase"
                     /protein_id="HEU5585484.1"
                     /translation="MMDSPKKLGYHMPAEYEPHHGTLMIWPTRPGSWPFQGKAAKRAF
                     TQIIETIAEGERVYLLVEQAYLYEAQSYLGDKVVYLDIPTNDAWARDTGPTILVNDKG
                     KKLAVDWAFNAWGGTYDGLYQDYEEDDQVASRFAEVLEKPVYDAKPFVLEGGAIHSDG
                     QGTILVTESCLLSPGRNPNLTKEEIENTLLESLGAEKVIWLPYGIYQDETNEHVDNVA
                     AFVGSAELVLAWTDDENDPQYAMSKADLELLEQETDAKGCHFTIHKLPIPAVRQVVTE
                     EDLPGYIYEEGEEERYAGERLAASYVNFYIANKAVLVPQFEDVNDQVAIDILSKCFPD
                     RKVVGIPARDILLGGGNIHCITQQIPE"
     gene            7192..8067
                     /gene="aguB"
                     /locus_tag="VVO18_000264"
     CDS             7192..8067
                     /gene="aguB"
                     /locus_tag="VVO18_000264"
                     /EC_number="3.5.1.53"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001246759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-carbamoylputrescine amidase"
                     /protein_id="HEU5585485.1"
                     /translation="MRNVRVATIQMQCAKDVATNIQTAERLVRQAAEQGAQIILLPEL
                     FEHPYFCQERQYDYYQYAQSVAENTAIQHFKVIAKELQVVLPISFYEKDGNVLYNSIA
                     VIDADGEVLGVYRKTHIPDDHYYQEKFYFTPGNTGFKVWNTRYAKIGIGICWDQWFPE
                     TARCLALNGAELLFYPTAIGSEPILDTDSCGHWQRTMQGHAAANIVPVIAANRYGLEE
                     VTPSEENGGQSSSLDFYGSSFMTDETGAILERAERQEEAVLLATYDLDKGASERLNWG
                     LFRDRRPEMYRQITD"
     gene            complement(8248..9057)
                     /locus_tag="VVO18_000265"
     CDS             complement(8248..9057)
                     /locus_tag="VVO18_000265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000593565.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5585486.1"
                     /translation="MIKLLALDMDGTLLNEAKEIPQAHITAIHKAIEKGVKLVLCTGR
                     PLFGVLPYYKKLELDLQNEYIIVNNGCSTHQTSDWSLVDWKELSPADIEYLYDLAEKS
                     DVQLTLFDESHYFVLGGKPNQVIENDAKLVFSDLTEISLEEATSGKFRMFQGMFLGTK
                     EQTDDFEQRFAEELCQRFSGVRSQPVIYEAMPLGTTKATALSRLAEILKIDSSEIMAM
                     GDANNDIEMLQFAGLGIAMGNASDYVKSLADAVTSSNEEDGVARAIEKYIL"
     gene            9329..9550
                     /locus_tag="VVO18_000266"
     CDS             9329..9550
                     /locus_tag="VVO18_000266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000602450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0924 family bacteriocin-like peptide"
                     /protein_id="HEU5585487.1"
                     /translation="MILMTKNINLTNEELELIQGGADPYGKNPNGRYDWEIEPVLTLP
                     VHGFCPRGTYDLGYIGGGNHLCKGSAARF"
     gene            9604..10275
                     /locus_tag="VVO18_000267"
     CDS             9604..10275
                     /locus_tag="VVO18_000267"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5585488.1"
                     /translation="MKKRAIQILLALSLIFYKSTWFWRVFNHLAKPYLPASREFFQIL
                     LLMESGVLFLAVIYLLVFAGKKIFHFKWQLRYFIYLLLGYIISYMSDFLFSYFISLSS
                     NQISLNETVEMMGRQEFPYFLLIVCFIAPIAEELIYRGVLMTTFFKNSPWYGDVLLSA
                     IIFGYIHINFALTPLAFFIYASGGLILALLYRMTKNLYYPILVHILINITAFWDVWLL
                     LFSGS"
     gene            complement(10327..10524)
                     /locus_tag="VVO18_000268"
     CDS             complement(10327..10524)
                     /locus_tag="VVO18_000268"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842783.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5585489.1"
                     /translation="MFIFYPQLLYLFIIPYFRSFPKRKKEHPILLNYLHYLPFSRQSY
                     FQNQFKKISGYTPLQYRKEKR"
     gene            10517..11425
                     /locus_tag="VVO18_000269"
     CDS             10517..11425
                     /locus_tag="VVO18_000269"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEU5585490.1"
                     /translation="MNIQQLRYVVAIANSGTFREAAEKMYVSQPSLSISVRDLEKELG
                     FKIFRRTSSGTFLTRRGMEFYEKAQELVKGFDIFQNQYANPEEEKDEFSVASQHYDFL
                     PPTITAFSERYPDYKNFRIFESTTVQILDEVAQGHSEIGIIYLNNQNKKGIMQRVEKL
                     GLEVIELIPFHTHIYLCEGHPLAQKEELVMEDLADLPTVRFTQEKDEYLYYSENFVDT
                     SASSQMFNVTDRATLNGILERTDAYATGSGFLDSDSVNGITVIRLKDNLDNRMVYVKR
                     EEVELSQAGTLFVEVMQEYFDQKRKS"
     gene            11422..11883
                     /locus_tag="VVO18_000270"
     CDS             11422..11883
                     /locus_tag="VVO18_000270"
                     /EC_number="3.4.23.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase II"
                     /protein_id="HEU5585491.1"
                     /translation="MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSL
                     TYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLG
                     NFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN"
     gene            11873..12760
                     /locus_tag="VVO18_000271"
     CDS             11873..12760
                     /locus_tag="VVO18_000271"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU5585492.1"
                     /translation="MEIKIETGGLRLDKALSDLSELSRSLANEQIKSGQVLVNGQVKK
                     AKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVYQDEDVAVVNKPQGMVVHPSAGHTS
                     GTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGLLMIAKNDDAHLALAQELKDKKS
                     LRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAKGKPAVTRFHVLERFGDYSLV
                     ELQLETGRTHQIRVHMAYIGHSVAGDEVYGPRKTLKGHGQFLHAKTLGFTHPRTGKTL
                     EFKADIPEIFKETLERLRK"
     gene            12763..14646
                     /gene="cbpE"
                     /locus_tag="VVO18_000272"
                     /gene_synonym="pce"
     CDS             12763..14646
                     /gene="cbpE"
                     /locus_tag="VVO18_000272"
                     /gene_synonym="pce"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine esterase CbpE"
                     /protein_id="HEU5585493.1"
                     /translation="MKKKLTSLALVGAFLGLSWYGNVQAQESSGNKIHFINVQEGGSD
                     AIILESNGHFAMVDTGEDYDFPDGSDSRYPWREGIETSYKHVLTDRVFRRLKELGVQK
                     LDFILVTHTHSDHIGNVDELLSTYPVDRVYLKKYSDNRITNSERLWDNLYGYDKVLQT
                     ASEKGVSVIQNITQGDAHFQFGDMDIELYNYENETDSSGELKKIWDDNSNSLISVVKV
                     NGKKIYLGGDLDNVHGAEDKYGPLIGKVDLMKFNHHHDTNKSNTKDFIKNLSPSLIVQ
                     TSDSLPWKNGVDSEYVNWLKERGIERINAASKDYDATVFDIRQDGLVNISTSYKPIPS
                     FQAGWHKSSYGNWWYQAPDSTGEYAVGWNEIKGEWYYFNQTGILLQNQWKKWNNRWFY
                     LTDSGVAAKNWKKIAGIWYYFNKENQMEIGWIQDKEQWYYLDVDGSMKTGWLQYKGQW
                     YYFAPSGEMKTGWVKDKEAWYYMDSTGIMKTGEIEVAGHHYYLEESGAMKQGWLKKAN
                     DWYFYKTDGSRAIGWIKDKDKWYFLKENGQLLVNGKTPEGYTVDSSGAWLVDVPIEKS
                     ATIKTTSHSEIKESKEVVKKDLENKETSQHESVTNSSTSQDLTSSTSQSSETSVNKSE
                     SEQ"
     gene            14726..15856
                     /locus_tag="VVO18_000273"
     CDS             14726..15856
                     /locus_tag="VVO18_000273"
                     /EC_number="2.7.2.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004240022.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate 5-kinase"
                     /protein_id="HEU5585494.1"
                     /translation="MNNRSETMKYKRIVFKVGTSSLTNEDGSLSRSKVKDITQQLAML
                     HEAGHELILVSSGAIAAGFGALGFKKRPTKIADKQASAAVGQGLLLEEYTTNLLLRQI
                     VSAQILLTQDDFVDKRRYKNAHQALSVLLNRGAIPIINENDSVVIDELKVGDNDTLSA
                     QVAAMVQADLLVFLTDVDGLYTGNPNSDPRAKRLERIETINREIIDMAGGAGSSNGTG
                     GMLTKIKAATIATESGVPVYICSSLKSDSMIEAAEETEDGSYFVAQEKGLRTQKQWLA
                     FYAQSQGSIWVDKGAAEALSQHGKSLLLSGIVEAEGAFSYGDIVTVFDKESGKSLGKG
                     RVQFGASALEDMLRSQKAKGVLIYRDDWISITPEIQLLFTEF"
     gene            15866..17128
                     /locus_tag="VVO18_000274"
     CDS             15866..17128
                     /locus_tag="VVO18_000274"
                     /EC_number="1.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate-5-semialdehyde dehydrogenase"
                     /protein_id="HEU5585495.1"
                     /translation="MVSRQEQFEQVQAVKKSINTASEEVKNQALLAMADHLVAATEEI
                     LAANALDMAAAKGKISDVMLDRLYLDADRIEAMARGIREVVALPDPIGEVLETSQLEN
                     GLVITKKRVAMGVIGIIYESRPNVTSDAAALTLKSGNAVVLRSGKDAYQTTHAIVTAL
                     KKGLETTTIHPNVIQLVEDTSRESSYAMMKAKGYLDLLIPRGGAGLINAVVENAIVPV
                     IETGTGIVHVYVDKDADEDKALSIINNAKTSRPSVCNAMEVLLVHENKAASILPRLDQ
                     MLVAERKEAGLEPIQFRLDSKASQFVSGQAAETQDFDTEFLDYVLAVKVVSSLEEAVA
                     HIESHSTHHSDAIVTENAEAAAYFTDQVDSAAVYVNASTRFTDGGQFGLGCEMGISTQ
                     KLHARGPMGLKELTSYKYVVAGDGQIRE"
     gene            17132..17929
                     /gene="proC"
                     /locus_tag="VVO18_000275"
     CDS             17132..17929
                     /gene="proC"
                     /locus_tag="VVO18_000275"
                     /EC_number="1.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="HEU5585496.1"
                     /translation="MKIGFIGLGNMGASLAKSVLQTRTSDEILLANRSQAKVDAFIAD
                     FGGQASSNEEMFAEADVIFLGVKPAQFSELLSQYQTILEKRESLLLISMAAGLTLEKL
                     ASLIPSQHRIIRMMPNTPASIGQGVISYALSPNCRAEDSELFCQLLSKAGLLVELGES
                     LINAATGLAGCGPAFVYLFIEALADAGVQTGLSRETALKMAAQTVVGAGQLVLESQQH
                     PGVLKDQVCSPGGSTIAGVASLEAHAFRGTVMEAVHQAYKRTQELGK"
     gene            18149..18787
                     /locus_tag="VVO18_000276"
     CDS             18149..18787
                     /locus_tag="VVO18_000276"
                     /EC_number="2.7.4.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTMP kinase"
                     /protein_id="HEU5585497.1"
                     /translation="MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGV
                     LIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSS
                     VAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDL
                     EGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKSVLFDGMGLAK"
     gene            18784..19674
                     /locus_tag="VVO18_000277"
     CDS             18784..19674
                     /locus_tag="VVO18_000277"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806705.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta'"
                     /protein_id="HEU5585498.1"
                     /translation="MKQDQLKAWQPAQFDRFVRILEQDQLNHAYLFSGFFGSLEIAQF
                     LAKSLFCTDKVGVLPCEKCRSCKLIEQEEFPDVTLIKPVNQVIKTERIRELVGQFSQA
                     GIESQQQVFIIEQADKMHPNAANSLLKVIEEPQSEVYIFFLTSDEEKMLPTIRSRTQI
                     FHFKKQEEKLILLLEQMGLVKKKATLLAKFSQSRAEAEKLANQASFWTLVDESERLLT
                     WLVAKKKESYLQVAKLANLADDKEKQDQVLRILEVLCGQDLLQVRVRVILQDLLEARK
                     MWQANVSFQNAMEYLVLKEI"
     gene            19714..20031
                     /gene="yabA"
                     /locus_tag="VVO18_000278"
     CDS             19714..20031
                     /gene="yabA"
                     /locus_tag="VVO18_000278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication initiation control protein YabA"
                     /protein_id="HEU5585499.1"
                     /translation="MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLE
                     NSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELL
                     YRE"
     gene            20034..20912
                     /gene="rsmI"
                     /locus_tag="VVO18_000279"
     CDS             20034..20912
                     /gene="rsmI"
                     /locus_tag="VVO18_000279"
                     /EC_number="2.1.1.198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (cytidine(1402)-2'-O)-methyltransferase"
                     /protein_id="HEU5585500.1"
                     /translation="MQIQKSFKGQSPYGKLYLVATPIGNLDDMTFRAIQTLKEVDWIA
                     AEDTRNTGLLLKHFDISTKQISFHEHNAKEKIPDLIGFLKAGQSIAQVSDAGLPSISD
                     PGHDLVKAAIEEEIAVVTVPGASAGISALIASGLAPQPHIFYGFLPRKSGQQKQFFDS
                     KKDYPETQIFYESPHRVADTLENMLEVYGDRSVVLVRELTKIYEEYQRGTISELLESI
                     SETSLKGECLLIVEGASQDVEEKDEEDLFLEIQARIQHGMKKNQAIKEVAKYYQWNKS
                     QLYAAYHEWEENQEND"
     gene            21099..22433
                     /gene="trmFO"
                     /locus_tag="VVO18_000280"
     CDS             21099..22433
                     /gene="trmFO"
                     /locus_tag="VVO18_000280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate--tRNA-(uracil(54)-
                     C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO"
                     /protein_id="HEU5585501.1"
                     /translation="MSQSYINVIGAGLAGSEAAYQIAERGIPVKLYEMRGVKSTPQHK
                     TDNFAELVCSNSLRGDALTNAVGLLKEEMRRLGSVILESAEATRVPAGGALAVDRDGF
                     SQMVTEKVVNHPLIEVVRDEITELPTDVITVVATGPLTSDALAEKIHALNDGDGFYFY
                     DAAAPIIDVNTIDMSKVYLKSRYDKGEAAYLNAPMTKQEFMDFHEALVNAEEAPLNSF
                     EKEKYFEGCMPIEVMAKRGIKTMLYGPMKPVGLEYPDDYTGPRDGEFKTPYAVVQLRQ
                     DNAAGSLYNIVGFQTHLKWGEQKRVFQMIPSLENAEFVRYGVMHRNSYMDSPNLLEQT
                     YRSKKQPNLFFAGQMTGVEGYVESAASGLVAGINAARLFKEESEAIFPDTTAIGSLAH
                     YITHADSKHFQPMNVNFGIIKELEGERIRDKKARYEKIAERALADLEEFLTV"
     gene            22517..23254
                     /locus_tag="VVO18_000281"
     CDS             22517..23254
                     /locus_tag="VVO18_000281"
                     /EC_number="2.7.4.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000013002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UMP kinase"
                     /protein_id="HEU5585502.1"
                     /translation="MANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSL
                     GIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQ
                     TAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILM
                     AKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNM
                     NQSGNIKRVVFGENIGTTVSNNIEEKE"
     gene            23263..23820
                     /gene="frr"
                     /locus_tag="VVO18_000282"
     CDS             23263..23820
                     /gene="frr"
                     /locus_tag="VVO18_000282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148672.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome recycling factor"
                     /protein_id="HEU5585503.1"
                     /translation="MANVIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEY
                     YGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDLGITPANDGSVIRLVI
                     PALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKQEKAKEITEDELKTLEKDI
                     QKVTDDAVKHIDDMTANKEKELLEV"
     gene            23880..24734
                     /gene="cvfB"
                     /locus_tag="VVO18_000283"
     CDS             23880..24734
                     /gene="cvfB"
                     /locus_tag="VVO18_000283"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001095444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding virulence regulatory protein CvfB"
                     /protein_id="HEU5585504.1"
                     /translation="MNTNLASFIVGLIIDENDRFYFVQKDGQTYALAKEEGQHTVGDT
                     VKGFAYTDMKQKLRLTTLEVTATQDQFGWGRVTEVRKDLGVFVDTGLPDKEIVVSLDI
                     LPELKELWPKKGDQLYIRLEVDKKDRIWGLLAYQEDFQRLARPAYNNMQNQNWPAIVY
                     RLKLSGTFVYLPENNMLGFIHPSERYAEPRLGQVLDARVIGFREVDLTLNLSLKPRSF
                     EMLENDAQMILTYLESNGGFMTLNDKSSPDDIKATFGISKGQFKKALGGLMKAGKIKQ
                     DQFGTELI"
     gene            24743..24958
                     /locus_tag="VVO18_000284"
     CDS             24743..24958
                     /locus_tag="VVO18_000284"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YozE family protein"
                     /protein_id="HEU5585505.1"
                     /translation="MRKSFYTWLMTERNPKSNSPKAILADLAFEEAAFPKHTDDFDEV
                     SRFLEEHASFSFNLGDFDAIWQEYLEH"
     gene            25044..26012
                     /locus_tag="VVO18_000285"
     CDS             25044..26012
                     /locus_tag="VVO18_000285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PhoH family protein"
                     /protein_id="HEU5585506.1"
                     /translation="MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEI
                     VQVLGEETACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEI
                     IKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKR
                     IILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAP
                     LAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSG
                     LIDAQEKLKNIHQIDFVHFSAKDVVRHPVVAQIIRAYEYSTEVAHD"
     gene            complement(25990..26169)
                     /locus_tag="VVO18_000286"
     CDS             complement(25990..26169)
                     /locus_tag="VVO18_000286"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585507.1"
                     /translation="MTQEDALIVISHIKVLSIVPNRCLKPLDKTFSLYNWIFLSQKYI
                     LLQANFLKISRVQLQ"
     gene            26205..26705
                     /locus_tag="VVO18_000287"
     CDS             26205..26705
                     /locus_tag="VVO18_000287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566985.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585508.1"
                     /translation="MIDQLSKYYSCRILTEKDIPSILSLYESNPLYFQHCPPEPNFAT
                     VKEDMLCLPEGKAKADKFFVGFWNGSDLVAVMDFVYAYPDEETVFIGLFMVDQAYQRK
                     GIGSHIVTEALAYFAKNCRKARLAYVKGNPQSQHFWEKQGFKSIGCEVKQELYTVVIA
                     EQSLED"
     gene            26708..26968
                     /locus_tag="VVO18_000288"
                     /pseudo
     CDS             26708..26968
                     /locus_tag="VVO18_000288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003069408.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TfoX/Sxy family protein"
     gene            complement(27335..27661)
                     /locus_tag="VVO18_000289"
     CDS             complement(27335..27661)
                     /locus_tag="VVO18_000289"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585509.1"
                     /translation="MVDVAVDQGGVIETADRVTTHDEPVYEKHGVLHYAVANIPGAVA
                     RTSTIALTNVTLPYIEALAGKGFAQAISEDEGLRQGVTTYQGYLTSLPVAQGLNRDYT
                     DINDLV"
     gene            complement(27607..28020)
                     /locus_tag="VVO18_000290"
     CDS             complement(27607..28020)
                     /locus_tag="VVO18_000290"
                     /inference="COORDINATES: protein motif:HMM:NF013430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-binding protein"
                     /protein_id="HEU5585510.1"
                     /translation="MGAHFLTKQAGGSGVLPGGVPGVPKGKVTIIGDGVVGTHAARIA
                     LGLGAQVTILDISAKRLSVLEEVFGSQIQTLISNSFNIEASVRDADVVIGAILIPGAK
                     APELVTDEMVKQMRPGSVSLTLLLTKVALSKQLTV"
     gene            complement(28021..28446)
                     /locus_tag="VVO18_000291"
     CDS             complement(28021..28446)
                     /locus_tag="VVO18_000291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine dehydrogenase"
                     /protein_id="HEU5585511.1"
                     /translation="MLIGIPKEIKNNENRVALTPAGVHSLVSRGHRVLIETNAGLGSG
                     FTDADYQKQGAEIVATAGEAWAAELVVKVKEPLSSEYGYLRDDLLLFTYLHMAAAPEL
                     ADAMLAAKTTGIAYETVRDNQGQLPLLVPMSEVADRMAV"
     gene            28623..29192
                     /locus_tag="VVO18_000292"
     CDS             28623..29192
                     /locus_tag="VVO18_000292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585512.1"
                     /translation="MESIFVKLAQYPSIETERLLLRPVTLDDAEAMFDYASDKGNTRY
                     TFPTNQSLEETKNNIAQFYLANPLGRWGIELKSNGQFIGTIDLHKIDSVLKKAAIGYI
                     INKKYWNQGLTTEANRAVIELAFEKIGMNKLTALHDKDNPASGKVMEKSGMRFSHAEP
                     YACMDQHEKDRIVTRVHYVLTKEDYFANK"
     gene            29260..29910
                     /locus_tag="VVO18_000293"
     CDS             29260..29910
                     /locus_tag="VVO18_000293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000387331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComEA family DNA-binding protein"
                     /protein_id="HEU5585513.1"
                     /translation="MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQ
                     AEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKGAVKSPGIYDLPVGSRVNDAVQK
                     AGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
                     SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD"
     gene            29894..32134
                     /locus_tag="VVO18_000294"
     CDS             29894..32134
                     /locus_tag="VVO18_000294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA internalization-related competence protein
                     ComEC/Rec2"
                     /protein_id="HEU5585514.1"
                     /translation="MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCL
                     FIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQNLADSVERVRILPDTIKVNGDSL
                     SFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
                     LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLL
                     GHLDTDFEEMNELYSSLGIIHLFALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPF
                     SLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIVMPNFFLTAGGVLSC
                     AYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDL
                     TFLPLLSILFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLI
                     SLALVYDLRKNIKKLTVLCLLITGLFLLTKHPLENEITMLDVGQGESIFLRDVTGKTI
                     LIDVGGKAESYKKTEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDKEHVGDL
                     LEVTKAFHVGEILVSKGSLKQKQFMVELQATQTKVRSMIVGENLPIFGSQLEVLSPRK
                     MGDGGHDDTLVLYGKFLDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSS
                     SPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGINSKVYRTDQQGAIRFKGLDSW
                     KIESVR"
     gene            32533..33120
                     /locus_tag="VVO18_000295"
     CDS             32533..33120
                     /locus_tag="VVO18_000295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000939891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585515.1"
                     /translation="MLQLTHVTLKTRQVILQDADFTFKKGRFYGLLAINGSGKTTLFR
                     AISNLIPISSGNIAAPPSLFYYESIEWLDGNLSGMDYLRLIKNIWKSDLNLRDEIAYW
                     EMADYISLPIRKYSLGMKQRLVIAMYFLSQAKCWLMDEITNGLDEYYRQKFFDRLAQI
                     DRQEQLVLLSSHYKEELVDVCDRVVTIHQGQIEEV"
     gene            33124..34308
                     /locus_tag="VVO18_000296"
     CDS             33124..34308
                     /locus_tag="VVO18_000296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585516.1"
                     /translation="MKDVSLFLLKKVFKSRLNWIVLALFVSVLGVTFYLNSQTANSHS
                     LESRLESRIAANERAINENEEKLSQMSDTSSEEYQFAKNNLDVQKNLLTRKTEILTLL
                     KEGRWKEAYYLQWQDEEKNYEFVSNDPTASSGLKMGVDRERKIYQALYPLNIKAHTLD
                     FPTHGIDQIVWILEVIIPSLFVVAIIFMLTQLFAERYQNHLDTAHLYPVSKVTFAISS
                     LGVGVGYVTVLFIGICGFSFLVGSLISGFGQLDYPYPIYSLVNQEVTIGKIQDVLFPG
                     LLLAFLAFIVIVEVVYLIAYFFKQKMPILFLSLIGIVGLLFGIQTIQPLQKIAHLIPF
                     TYLRSVEILSGRLPKQIDNVNLNWSMGMVLLPCLIIFLLLGILFIERWGSSQKKEFFN
                     RF"
     misc_feature    34472..34603
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00558"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L20 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00558"
     gene            34619..35149
                     /gene="infC"
                     /locus_tag="VVO18_000297"
     CDS             34619..35149
                     /gene="infC"
                     /locus_tag="VVO18_000297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-3"
                     /protein_id="HEU5585517.1"
                     /translation="MKTIAKQDLFINDEIRVREVRLIGLEGEQLGIKPLSEAQALADN
                     ANVDLVLIQPQAKPPVAKIMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPTIDKGD
                     FDTKLRNARKFLEKGNKVKVSIRFKGRMITHKEIGAKVLAEFAEATQDIAIIEQRAKM
                     DGRQMFMQLAPATDKK"
     gene            35182..35382
                     /gene="rpmI"
                     /locus_tag="VVO18_000298"
     CDS             35182..35382
                     /gene="rpmI"
                     /locus_tag="VVO18_000298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001125942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L35"
                     /protein_id="HEU5585518.1"
                     /translation="MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHL
                     RKASMVHSGDYKRIKAMLTRLK"
     gene            35434..35793
                     /gene="rplT"
                     /locus_tag="VVO18_000299"
     CDS             35434..35793
                     /gene="rplT"
                     /locus_tag="VVO18_000299"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019786714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L20"
                     /protein_id="HEU5585519.1"
                     /translation="MARVKGGVVSRKRRKRILKLAKGYYGAKHILFRTAKEQVMNSYY
                     YAYRDRRQKKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEIEVNRKMLADLAVND
                     AVAFTALADAAKAKLGK"
     gene            35851..36231
                     /locus_tag="VVO18_000300"
     CDS             35851..36231
                     /locus_tag="VVO18_000300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU5585520.1"
                     /translation="MASKMLHTCLRVENLEKSIAFYQDAFGFKELRRRDFPDHAFTIV
                     YLGLEGDDYELELTYNYDHGPYVVGDGFAHIALSTPDLEALHQEHSAKGYEVTEPNGL
                     PGTTPNYYFVKDPDGYKVEVIREK"
     gene            36481..37281
                     /locus_tag="VVO18_000301"
     CDS             36481..37281
                     /locus_tag="VVO18_000301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase electron transfer
                     subunit"
                     /protein_id="HEU5585521.1"
                     /translation="MNLTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRA
                     GQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMG
                     PQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILK
                     TELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHP
                     RAYLSLESRMACGMGACYACVLKVPENETVSQRVCEDGPVFRTGTVVL"
     gene            37292..38230
                     /locus_tag="VVO18_000302"
     CDS             37292..38230
                     /locus_tag="VVO18_000302"
                     /EC_number="1.3.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate dehydrogenase"
                     /protein_id="HEU5585522.1"
                     /translation="MTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLDLLGSI
                     MIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAEKLPWLEREYPNLPIIA
                     NVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAA
                     VEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGT
                     GGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFT
                     NPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR"
     gene            38272..40305
                     /locus_tag="VVO18_000303"
     CDS             38272..40305
                     /locus_tag="VVO18_000303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010976495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="HEU5585523.1"
                     /translation="MNLGEFWYNKINKNRGRRLMKKVRFIFLALLFFLASPEGAMASD
                     GTWQGKQYLKEDGSQAANEWVFDTHYQSWFYIKADANYAENEWLKQGDDYFYLKSGGY
                     MAKSEWVEDKGAFYYLDQDGKMKRNAWVGTSYVGATGAKVIEDWVYDSQYDAWFYIKA
                     DGQHAEKEWLQIKGKDYYFKSGGYLLTSQWINQAYVNASGAKVQQGWLFDKQYQSWFY
                     IKENGNYADKEWIFENGHYYYLKSGGYMAANEWIWDKESWFYLKFDGKMAEKEWVYDS
                     HSQAWYYFKSGGYMTANEWIWDKESWFYLKSDGKIAEKEWVYNSHSQAWYYFKSGGYM
                     TANEWIWDKESWFYLKSDGKMAEKEWVYDSHSQAWYYFKSGGYMAKNETVDGYQLGSD
                     GKWLGGKATNENAAYYQVVPVTANVYDSDGEKLSYISQGSVVWLDKDRKSDDKRLAIT
                     ISGLSGYMKTEDLQALDASKDFIPYYESDGHRFYHYVAQNASIPVAFHLSDMEVGKKY
                     YSADGLHFDGFKLENPFLFKDLTEATNYSAEELDKVFSLLNINNSLLENKGATFKEAE
                     EHYHINALYLLAHSALESNWGRSKIAKDKNNFFGITAYDTTPYLSAKTFDDVDKGILG
                     ATKWIKENYIDRGRTFLGNKASGMNVEYASDPYWGEKIASVMMKINEKLGGKD"
     gene            complement(40366..42021)
                     /gene="pavA"
                     /locus_tag="VVO18_000304"
     CDS             complement(40366..42021)
                     /gene="pavA"
                     /locus_tag="VVO18_000304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_094859469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rqc2 family fibronectin-binding protein PavA"
                     /protein_id="HEU5585524.1"
                     /translation="MSFDGFFLHHIVEELRNELVNGRIQKINQPFEQELVLQIRSNRQ
                     SHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEM
                     TVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGS
                     TYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEK
                     LSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQA
                     SELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILD
                     NYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVET
                     VLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQN
                     EELTFKMARKEELWFHAKDIPGSHVIISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQ
                     VDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS"
     gene            42126..42623
                     /gene="ybeY"
                     /locus_tag="VVO18_000305"
     CDS             42126..42623
                     /gene="ybeY"
                     /locus_tag="VVO18_000305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="HEU5585525.1"
                     /translation="MYIEMVDETGQVSKEMLQQTQEILEFAAQKLGKEDKEMAVTFVT
                     NERSHELNLEYRDTDRPTDVISLEYKPELEIAFDEEDLLENPELAEMMSEFDAYIGEL
                     FISIDKAHEQAEEYGHSFEREMGFLAVHGFLHINGYDHYTPEEEAEMFGLQEEILTAY
                     GLTRQ"
     gene            42604..42999
                     /locus_tag="VVO18_000306"
     CDS             42604..42999
                     /locus_tag="VVO18_000306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000378166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase"
                     /protein_id="HEU5585526.1"
                     /translation="MDSQDNKRKWKNRDLISSLEFAITGIFTAIKEERNMRKHAVTAL
                     VVILAGFVFQVSRIEWLFLLLSIFLVVAFEIINSAIENMVDLASHYHFSMLAKNAKDM
                     AAGAVLVVSLFAALTGALIFLPRIWDLLF"
     gene            43016..43915
                     /gene="era"
                     /locus_tag="VVO18_000307"
     CDS             43016..43915
                     /gene="era"
                     /locus_tag="VVO18_000307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase Era"
                     /protein_id="HEU5585527.1"
                     /translation="MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKI
                     MGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGD
                     DMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
                     LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMK
                     RDEETDKVHIRATIMVERDSQKGIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWV
                     KVKKNWRDKKLDLADFGYNEREY"
     gene            43964..44788
                     /gene="mutM"
                     /locus_tag="VVO18_000308"
     CDS             43964..44788
                     /gene="mutM"
                     /locus_tag="VVO18_000308"
                     /EC_number="3.2.2.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001114577.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-formamidopyrimidine glycosylase"
                     /protein_id="HEU5585528.1"
                     /translation="MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRE
                     LPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGG
                     TLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSH
                     LLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGS
                     TIRTYTNAFGEDGSMQDFHQVYDKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD"
     gene            44788..45393
                     /locus_tag="VVO18_000309"
     CDS             44788..45393
                     /locus_tag="VVO18_000309"
                     /EC_number="2.7.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dephospho-CoA kinase"
                     /protein_id="HEU5585529.1"
                     /translation="MRKIIGITGGIASGKSTVTNFLRQQGFQVVDADAVVHQLQKSGG
                     RLFEALVQHFGQEIILENGELNRPLLASLIFSNPEEQKWSKQIQGEIIREELATLREQ
                     LAQTEEIFFMDIPLLFEQDYSDWFAETWLVYVDRDTQVERLMKRDQLSKDEAESRLAA
                     QWPLEKKKDLASQVLDNNGNQNQLLNQVHILLEGGRQDDRD"
     gene            45380..46579
                     /locus_tag="VVO18_000310"
     CDS             45380..46579
                     /locus_tag="VVO18_000310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux MFS transporter"
                     /protein_id="HEU5585530.1"
                     /translation="MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSEQ
                     VAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYW
                     LIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAE
                     LFGIRTVFLLVGSFLFLAAILTICFIKEVFQPVAKEKAIPTKELFTSVKYPYLLLNLF
                     LTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDK
                     VGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPK
                     AGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRT
                     LLKVKEI"
     gene            46579..46728
                     /gene="rpmG"
                     /locus_tag="VVO18_000311"
     CDS             46579..46728
                     /gene="rpmG"
                     /locus_tag="VVO18_000311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU5585531.1"
                     /translation="MRVKINLKCSSCDSINYLTSKNSKTHPDKIEVLKYCPKERKVTL
                     HLESK"
     gene            46768..47001
                     /gene="secG"
                     /locus_tag="VVO18_000312"
     CDS             46768..47001
                     /gene="secG"
                     /locus_tag="VVO18_000312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecG"
                     /protein_id="HEU5585532.1"
                     /translation="MYNLLLTILLVLSVVIVIAIFMQPTKNQSSNVFDASSGDLFERS
                     KARGFEAVMQRLTGILVFFWLAIALALTVLSSR"
     gene            47103..49457
                     /gene="rnr"
                     /locus_tag="VVO18_000313"
     CDS             47103..49457
                     /gene="rnr"
                     /locus_tag="VVO18_000313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease R"
                     /protein_id="HEU5585533.1"
                     /translation="MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMER
                     KHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAI
                     DGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
                     KISQPIYVKKPALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVL
                     ESMDIVSEFPEAVVKEAESVPDAPSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIK
                     ALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVVPMLPERLSNGICSL
                     NPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHK
                     IVPSIELMAKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIE
                     SFMLMANETVAEHFSKLDLPFIYRIHEEPKAEKVQKFIDYASSFGLRIYGTASEISQE
                     ALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSPIRRYPD
                     LLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYV
                     GEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVG
                     QQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSRSGRGRGSNRRSDKKEDKRKS
                     GRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK"
     gene            49420..49887
                     /gene="smpB"
                     /locus_tag="VVO18_000314"
     CDS             49420..49887
                     /gene="smpB"
                     /locus_tag="VVO18_000314"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894882.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SsrA-binding protein SmpB"
                     /protein_id="HEU5585534.1"
                     /translation="MAKGEGKVVAQNKKARHDYTIVDTLEAGMVLTGTEIKSVRAARI
                     NLKDGFAQVKNGEVWLSNVHIAPYEEGNIWNQEPERRRKLLLHKKQIQKLEQETKGTG
                     MTLVPLKVYIKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARVMKAVNQR"
     gene            49903..50763
                     /gene="tehB"
                     /locus_tag="VVO18_000315"
     CDS             49903..50763
                     /gene="tehB"
                     /locus_tag="VVO18_000315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent methyltransferase TehB"
                     /protein_id="HEU5585535.1"
                     /translation="MEKLVAYKRMPLWNKQTMPEAVQQKHNTKVGTWGKITVLKGALK
                     FIELTEEGEVLAEHLFEAGADNPMAQPQAWHRVEAATDDVEWYLEFYCKPEDYFAKKY
                     NTKPVHSEVLEAMQTVKQGKALDLGCGQGRNSLFLAQQDFDVTAVDQNGLALEILQSI
                     VEQEDLDIPVDLYDINSASIGQEYDFIVSTVVLMFLQADRIPAIIQNMQEKTSVGGYN
                     LIVCAMDTEDYPCSVNFPFTFKEGELADYYKDWELVKYNENPGHLHRRDENGNRIQLR
                     FATLLAKKIK"
     gene            50836..51789
                     /gene="coiA"
                     /locus_tag="VVO18_000316"
     CDS             50836..51789
                     /gene="coiA"
                     /locus_tag="VVO18_000316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000495911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein CoiA"
                     /protein_id="HEU5585536.1"
                     /translation="MFVARDARGELVNVLEDKLEKQAYTCPACGGQLHLRQGPSVRTH
                     FAHKSLKDCDFFFENESPEHLANKESLYHWLKKETKVQLEYPLSELKQIADVFVNGNL
                     ALEVQCSPLPQKVLKERSEGYRSQGYQVLWLLGQKLWLKERLTRLQQGFLYFSQNMGF
                     YVWELDKEKQVLRLKYLIYQDLRGKLHYQIKEFSYGQGSLLEILRLPYKRQKISHFTV
                     SEDKDICRYIRQQLYYQNLFWMKEQAEAYQKGENILTYGLKEWYPQIRPIVGKFFQIE
                     QDLTSYYQHFYTYYQKNPQNDWQKLYPPAFYQQYFLKNMVE"
     gene            51808..53619
                     /gene="pepF"
                     /locus_tag="VVO18_000317"
     CDS             51808..53619
                     /gene="pepF"
                     /locus_tag="VVO18_000317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEU5585537.1"
                     /translation="MVLQRNERNEINEKDTWDLSTIYPTDQAWEEALKDLTEQLETVA
                     QYEGHLLDSADNLLEITEFSLEMERQMEKLYVYAHMKNDQDTREAKYQEYYAKAMTLY
                     SQLDQAFSFYDPEFMEISEKQYADFLEAQPKLQVYQHYFDKLLQGKDHVLSQREEELL
                     AGAGEIFGSASETFAILDNADIVFPYVLDDDGKEVQLSHGTYTRLMESKKREVRRGAY
                     QALYATYEQFQHTYAKTLQTNVKVQNYRAKVRNYKSARHAALAANFVPESVYDNLVAA
                     VRKHLPLLHRYLELRSKILGISDLKMYDVYTPLSSVEYNFTYQEALKKAEDALAVLGE
                     DYLSRVKRAFSERWIDVYENQGKRSGAYSGGSYDTNAFMLLNWQDNLDNLFTLVHETG
                     HSMHSSYTRETQPYVYGDYSIFLAEIASTTNENILTEKLLEEVEDDATRFAILNNFLD
                     GFRGTVFRQTQFAEFEHAIHQADQNGEVLTSDFLNKLYADLNQEYYGLSKEDNPEIQY
                     EWARIPHFYYNYYVYQYSTGFAAASALAEKIVHGSQEDRDRYIDYLKAGKSDYPLNVM
                     RKAGVDMEKEDYLNDAFAVFERRLNEFEALVEKLGLA"
     gene            53621..54334
                     /locus_tag="VVO18_000318"
     CDS             53621..54334
                     /locus_tag="VVO18_000318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812425.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-methyltransferase"
                     /protein_id="HEU5585538.1"
                     /translation="MVESYSKNANHNMRRPVVKEEIVDLMRQRQKQVTGFLKELEDFA
                     RKENIPIIPHETVAYFRFLMETMQPKNILEIGTAIGFSALLMAEHAPNAKITTIDRNP
                     EMIGFAKENFAQFDSRKQITLLEGDAVDVLSTLTESYDFVFMDSAKSKYIVFLPEILK
                     HLEVGGVVVLDDIFQGGDVAKDIMEVRRGQRTIYRGLQKLFYATLDNPELTATLVPLG
                     DGILMLRKNVADVQLSESE"
     gene            54401..55342
                     /gene="prsA"
                     /locus_tag="VVO18_000319"
     CDS             54401..55342
                     /gene="prsA"
                     /locus_tag="VVO18_000319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="HEU5585539.1"
                     /translation="MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFY
                     EQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAG
                     MTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAK
                     EVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGV
                     SDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIG
                     KELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE"
     gene            complement(55459..55800)
                     /locus_tag="VVO18_000320"
                     /pseudo
     CDS             complement(55459..55800)
                     /locus_tag="VVO18_000320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
BASE COUNT        16681 a        10322 c        12710 g        16118 t
ORIGIN      
        1 attttttatc aaaaaatact ttacaagttc ttaaaaacat gatatagtaa taaagcttag
       61 aaaatgagat gatgttttct agcaaatata aacccgagta aaaaatgcct acggacaggc
      121 agggttgaat gccgaagcgt ggttgaaaag ccacattatt gatagggtta aaagcctact
      181 tttataagtt gatgttagga cacttgttct aattcataaa tttttagtgt ggtgaaagca
      241 cacgtcatct tgtgaaacga tcaataaagt acgtaatatt tgctactaga gagttaggaa
      301 acatcgggaa cagacatact caacagaaac caaaataaac acgtcagaag attgcagagc
      361 aggtgaaaac ctgctctttt ttcatgagtc aacctttagt tccttagttt tcataaggtc
      421 ctaaaaatat tgaaaggagt atgttttgaa agagttagat caaaaccaag ccccaattta
      481 tgaggccttg gtgaagttac gcaagaaaag gattgttccc tttgatgttc caggtcacaa
      541 gcgtggacgg ggaaatccag aacttgtcga actcttagga gaaaaatgtg taggcattga
      601 tgtcaattcg atgaaaccct tggataattt aggccatcct atttcgatta ttcgtgatgc
      661 agaggagctg gctgcagatg cttttggagc tagccatgcc tttctaatga ttggtggaac
      721 aacttcatcg gtgcagacta tgattctggc aacctgcaag gcaggagata agattattct
      781 gccacgaaat gtccataaat ctgctatcaa tgcgttggtt ctatgtggtg ccattcccat
      841 ctatatcgag atgagtgtag atcctaagat tggtatcgct ttaggtcttg aaaatgaccg
      901 agtagcacag gccataaagg accatccaga tgctaaggct atcctaatca acaatcctac
      961 ttactacggc atctgttcag acctaaaggg gttgacagaa atggctcatg aagctggcat
     1021 gatggtttta gtagatgaag cccatggagc gcatttgcat ttcactggta aacttccaat
     1081 ttctgctatg gctgcaggag ctgatatggc agcagtttcc atgcataagt ctggtgggag
     1141 tttgacacaa agttcgcttc ttttaatcgg ggagcagatg aatcccgagt acgttcgtca
     1201 gattataaac ctgacccagt ctacatctgc ctcttactta ttgatggcta gtttggatat
     1261 ttcacgtcgc aacttggccc ttcgtggtaa agagtcgttt gaggaagtca ttgagctatc
     1321 cgagtacgct cgtcatgaaa tcaatgccat tggcggttac tatgcttact caaaagagtt
     1381 aatagatggt gtgtcggtct gtgattttga tgtaaccaag ttgtcagttt acactcaggg
     1441 aataggctta acaggtatcg aggtttatga cctcttgcga gacgaatacg acattcagat
     1501 tgagtttggt gatatcggca atatcttggc ctatatttcc atcggcgacc gcatccaaga
     1561 catcgagcgc ttggttggtg ctctggctga tattaagaga ctctattcac gagatgggaa
     1621 ggacttaata gctggagaat atattcagcc cgagttggtg ctgtctccac aagaagcctt
     1681 ctattcagag agaaaaagtt tgaccttaga tgagtctgtt ggacaggtct gtggagaatt
     1741 tgtcatgtgc tatcctccag ggattcctat cttggctcct ggtgaacgta ttacacgaga
     1801 aattgtagac tatatccaat tcgccaagga acgtggttgc tccctccaag ggacggaaga
     1861 tccagaggtc aatcatatca acgttattaa gagaaagaca aactataaga aaagtcaata
     1921 gttttatcta aactatttct tatttcaatt tgatgatttg gcgatgattt tagagcacgg
     1981 caaaaagccc ttgaattaga agcggtcaat cgcttaattt ctatcagctt atcaaatcct
     2041 gcctcaatcc ttttctgagg attagggtag cgtgtcaaga gttggtaggt atattctgaa
     2101 tgctttccaa cgattttatc caactcagga aagatgatat caagacaacg agtgtattgt
     2161 actttccaat cagactgttt ttcttgagac gatgaatatg tctagccagt atttttaggt
     2221 ctacttgccg attatcgtgt tgaaattgtt cacgattggg gtcagaaaga agtttaagag
     2281 cgatgccatg agcgtctttc ttatccgttt tagtcttgcg aagtgataat gatttggcaa
     2341 attccttgat gagcaaagga ttgtaggtgt aaactttata tccttgttca tgcaggaagt
     2401 tcagtagatt aaaggcataa tgtccagtat cttcaagagc gatgagacag tcttggttga
     2461 gctgtcgaag agacagatct aagagttcaa aaccagcttt attatttgaa aaagtgagtg
     2521 gtttaagaac agtttttcct tgaacattca aggctgtaac atcgtgttta tttttagcga
     2581 catcaatgcc cacataaagc atgggagtac ctccagatgt agtatttcaa gtctacttgg
     2641 ttatccacga actttttgcc ttgttacctt agacgagata aaacgtctat gcgttatcaa
     2701 actcattacc aattgaaaca aaagctgtgg ttagagcctt tcggaaatcg tcaagcgatt
     2761 ggaggaaatg aactaatcca cagtggctta ttccaagtat accacttggg ctttggcagt
     2821 agctaactgc gctaaatata atataaggag aaatagatgg atttatggtt ttctgaagtt
     2881 catactccag atgtcaaatt gtctctgaga acagccaagc aactttacgc tggaaaaagt
     2941 gaatggcagg atatcgaagt cttggatacg ccagcttttg ggaaaatact gattttaaat
     3001 ggccatgtct tgttctcaga tgcggatgat ttcgtctaca atgaaatgac cgttcacgtt
     3061 cccatggctg tccacccaaa tccaaagaaa gtattggtta ttgggggtgg tgacggcggt
     3121 gttgcccaag tattaacact ctatcctgaa ctggaacaaa tcgatatcgt ggaaccggat
     3181 gagatgttgg tcgaggtctg tcgtgagtat ttcccagact ttgctgcagg gctagatgat
     3241 cctcgtgtta ccatttacta ccaaaatggg ctacgctttt tgcgaaactg cgaagatgat
     3301 tacgatatta tcatcaacga tgcgacagat ccatttggcc atacggaagg actctttacc
     3361 aaggaattct acggcaatag ttatcgagct ctgaaggaag acggcatcat gatttaccag
     3421 catgggagtc ccttctttga cgaggatgag tcggcctgcc gaagcatgca ccgcaaggtc
     3481 aatcaagcct ttccaatcag tcgggtttat caggcccata ttccaactag cccagctggc
     3541 tattggttgt ttggatttgc atcgaaaaaa taccaccctg tcaaagattt tgacaaggaa
     3601 ggttggaaaa aacgccagct tttcacagaa tactacactg caaacttaca cgtgggagcc
     3661 tttatgttgc ccaagtatgt tgaggacatt ttagaagaag aggaaggaaa aaaatgagtc
     3721 gtttactagt tattggttgt gggggcgttg cccaagttgc tatttcaaaa atttgtcaag
     3781 atagcgaaac atttacagag attatgattg ctagccgtac caagtcaaaa tgcgatgact
     3841 tgaaagcgaa gctagaaggc aaaacaagta ctaaaattga aactgcagca cttgatgctg
     3901 acaaggtaga agaggtcatt accttgattg aaagctacaa accagaagct gttttgaatg
     3961 tagctctgcc ttatcaagat ttaaccatta tggatgcttg tttggcaaca ggtgttcact
     4021 atatcgatac agccaactac gaagcagaag acacagaaga ccctgagtgg cgtgctatct
     4081 acgaaaaacg ttgtaaggaa cttggtttta cagcctactt tgactactca tggcagtggg
     4141 cttatcaaga gaaattcaaa gaagcaggct tgactgctct tcttggttct ggttttgacc
     4201 caggtgtaac tagtgtcttt tcagcttatg ccctcaaaca ctattttgat gaaatccatt
     4261 atatcgacat tttagactgt aatggcggtg accacggtta tccatttgca accaacttta
     4321 atccagaaat taatctccgt gaggtttctg cgccaggttc ttactgggaa gatgggaaat
     4381 gggtcgaagt cgaagctatg tctatcaagc gtgagtatga tttccctcaa gttggacaaa
     4441 aagatatgta tctccttcac catgaagaaa tcgaatcatt ggccaagaac attccaggtg
     4501 tcaaacgcat tcgtttcttt atgacttttg gtcaatctta cttgacgcac atgaaatgtc
     4561 ttgaaaatgt tggactcctt cgtacggata ccattaactt taacggccaa gaaattgttc
     4621 caattcaatt tttgaaagcc ttgcttccag atcctgctag ccttggccca cgtactgtag
     4681 gtaaaaccaa tattggatgt atctttacag gtgtcaaaga tggcgttgaa aagactatct
     4741 acatctacaa tgtttgcgac catcaagagt gctatgcaga agtcgggtca caagcaattt
     4801 catacacgac aggcgttcca gccatgattg ggacaaaatt agtcatgaac ggaacttgga
     4861 aacaagctgg agtgtataac cttgaggagt tagatccaga tccattcatg gaagctttga
     4921 atgagtatgg tttgccatgg gttgtggttg aaaatccaca aatggtggac taatgaagtt
     4981 agaacaagta ccaacaccag cctatgttat tgacttggcc aagttagaag ctaattgccg
     5041 cattctacaa tatgtacaag aagaggtcgg ttgcaaggtc ttgcttgccc agaaggcata
     5101 ttccctctac aaaacttatc ccttgattag ccagtatcta tcaggtacga cagctagtgg
     5161 actctatgag gccaaattgg caagggaaga atttcctggt gaagtccatg tatttgcgcc
     5221 tgctttcaag gatgcagact tggaggaatt gcttgggata acagaccata tcgtctttaa
     5281 ctcagagaga cagttgcgta agcatggggc tcgttgtcga gaggctggtg tcagtgttgg
     5341 tttgcgcctc aaccctcagt gttcaactca aggagatcac gcgctctatg acccttgtgc
     5401 acctggttct cgctttggag ttactataga caagattccg agtgatttgc tagatttggt
     5461 tgacggactt cattttcata ccctttgcga gcagggagca gatgatttac aaacaacttt
     5521 gaaagcagta gaagaacagt ttggtcccta cttacatgag gtaaaatggc tcaatatggg
     5581 tggtggtcat catattacaa gagaaggtta cgatgtggat ttgctgattt cagaaatcaa
     5641 gcgtatccga aaaacttaca atcttgaaat ctatatcgag cctggtgaag ccattgcgct
     5701 taatgcgggt tatttagcaa ctgaggtatt agatattgta gaaaacggta tggaaatctt
     5761 ggttttagac gcctctgcga cctgccatat gcctgatgta cttgagatgc cctatcgtcc
     5821 acctttgaga aatggctttg agtcacagga aaaagcccat acctacagac tttcttctaa
     5881 tacctgtctg acgggcgatg tgattggtga ttatagtttt gaaaatccag tccaaatcgg
     5941 agacagactt tattttcaag acatggccat ttattctttt gtcaaaaata atacctttaa
     6001 tggtattgga ttgccaagtc tctatctcat ggacgaacag ggagactgta gcttactcaa
     6061 agcttttggc tatcaagact ttaaagggag attatcatga tggacagtcc aaaaaaatta
     6121 ggctatcaca tgccagcaga gtacgaaccc catcatggta ccctcatgat atggccgact
     6181 cgaccaggat catggccttt tcaaggaaag gctgctaaaa gagcatttac tcagatcatc
     6241 gagaccatag cagaagggga aagagtctat cttttggtgg agcaggccta tctatatgaa
     6301 gcccaatcct atcttggaga caaggttgtt tatttagaca ttcccaccaa tgatgcctgg
     6361 gcgcgtgata ctggcccaac cattctcgtc aatgataaag gtaagaaatt agccgtggat
     6421 tgggccttca atgcttgggg aggcacctat gatggtcttt atcaagatta tgaagaggat
     6481 gaccaagtag ccagtcgttt tgctgaggtc ttggaaaagc ctgtctatga tgctaaacct
     6541 tttgtactgg aaggaggcgc aatccatagc gatggtcaag gaactattct cgtaactgaa
     6601 agttgcttgc ttagtcctgg tcgcaatcct aacctgacta aagaggagat tgaaaacaca
     6661 ttattagaaa gtcttggtgc tgaaaaagtt atttggcttc cttatggtat ttatcaggat
     6721 gaaaccaatg aacacgtcga taatgttgct gcctttgttg gttctgctga gcttgttttg
     6781 gcttggacag atgacgaaaa tgatccccag tatgccatgt caaaagcaga tctcgaactc
     6841 ttagaacagg aaacagatgc aaaaggttgt cacttcacca ttcataaatt gcctatccct
     6901 gcagttcgac aagttgtgac agaagaagat ttgccaggct acatctatga agaaggagaa
     6961 gaagagcgat acgcaggtga acgactagca gcttcctacg taaactttta tatcgccaac
     7021 aaggctgtct tggttccaca gtttgaggat gtaaacgacc aagtggccat agatatcctc
     7081 agcaagtgtt tcccagaccg taaagttgtc ggaataccag ccagagatat tctcttaggt
     7141 ggtggcaata tccactgtat cacccaacaa attccagaat aggagaaaaa gatgagaaat
     7201 gtaagagttg caaccattca gatgcaatgc gctaaggatg tggcaacaaa tatccaaacc
     7261 gcagagcgtt tagtacgtca ggctgctgag caaggagccc aaattattct cttgcccgag
     7321 ttgtttgaac atccctattt ctgtcaggaa cgtcagtatg actactacca gtatgcccaa
     7381 tctgtagcgg aaaatactgc aattcagcat tttaaggtga ttgctaagga actacaagtt
     7441 gttttaccaa tcagtttcta tgaaaaagat ggtaatgtct tgtataactc tattgccgtc
     7501 attgatgcag atggggaagt gctgggcgtt tatcgaaaga cccacatacc agatgaccat
     7561 tattatcaag aaaaattcta tttcacgcct ggtaacactg gtttcaaggt ctggaatact
     7621 cgctatgcta agattggtat cggtatctgt tgggatcaat ggttccctga aacagcgcgc
     7681 tgtcttgcat tgaatggtgc tgaattgctc ttttatccta cagctatcgg ttcagagcca
     7741 attttggata cagatagttg tggtcactgg caacgtacta tgcaagggca cgcagcagcg
     7801 aatattgttc cagtcatcgc agccaatcgt tatggtttag aggaggttac tcctagtgag
     7861 gaaaatggcg gacagagttc cagtcttgac ttctacggtt cctcctttat gacggatgaa
     7921 acaggagcta ttctagaacg agctgaaaga caagaagaag ctgttctgtt agctacttat
     7981 gacctagaca agggagcaag tgaacgccta aactggggct tgtttcgaga tagaagacca
     8041 gaaatgtata gacaaattac agattagtgt gggagaaatg agagattcat tctgctagac
     8101 taacttctta ttagcaacta taagatacta tggcatctag taaatcgatt tttatgattc
     8161 gctattcttg tctattgatt agtccgtatt ttaaaatatt agcaaaaaag caaatagcag
     8221 taacttctgt ctatttgctt ttctttttta tagaatatat ttctcaatag cacgcgcaac
     8281 gccgtcttct tcgttgcttg aggtaacggc atccgcaaga gatttgacat aatcgctggc
     8341 atttcccatt gcaatcccaa gccctgcaaa ctggagcatt tcgatatcgt tattagcatc
     8401 gcccatggcc ataatctctg aggaatcaat cttcaaaatc tcagctagtc gtgaaagagc
     8461 agtagccttt gtcgttccaa gcggcattgc ttcataaatg acaggctgcg aacgaactcc
     8521 actgaatcgt tggcaaagct cttcagcaaa acgctgctca aaatcgtctg tttgttcttt
     8581 tgttcctaaa aacatacctt ggaacatccg gaactttcca ctagtcgctt cttcaagaga
     8641 aatttcagtc aggtctgaaa atactagttt agcatcattt tcaataactt gattgggttt
     8701 gccaccgaga acaaaataat gtgactcgtc aaaaagtgtc aactgaacat cactcttttc
     8761 agcaaggtca tagaggtatt cgatgtcagc tggactcagt tctttccagt caactagact
     8821 ccaatcactg gtctggtgag ttgaacaacc gttgttaaca ataatatatt cgttctggag
     8881 gtcaagctcc agttttttgt agtaggggag gacaccgaaa agggggcgac ccgtacagag
     8941 aaccagtttg acaccttttt caatggcttt gtgaatagca gtaatgtgag cttgtgggat
     9001 ttccttggct tcattgagga gggtgccgtc catatccaag gctagtagtt taatcatagg
     9061 tcttccttct ttatcttttg ctattattat agcatatttt tgagaagaaa ttgatagaaa
     9121 gcttgagact aattgatttt atagtttaag atgttttgat gacaattcat gatttgaaga
     9181 ggatatttcg caaagatatg ctatactatg tttgtcaatg ttgcaactag acaaattaaa
     9241 aaaccaactt aatataatag tttttttgta agtaggtatg agtatcagat tactcaacta
     9301 atctgaagaa taatggagga aatatatcat gattttaatg acaaaaaata taaatctaac
     9361 aaatgaagaa ttagagctga tacaaggtgg agcagatcca tatggtaaaa atcctaatgg
     9421 taggtacgat tgggaaatag aaccagtatt aactctgccg gttcatggat tttgtcccag
     9481 aggcacctat gatttaggat atattggagg aggcaatcat ctttgcaaag gaagtgctgc
     9541 gagattttaa gtaaaattta ttagtaatat gaagaaacaa gtggagaaag cagagaattt
     9601 aatatgaaaa aacgggctat tcaaatttta ctagcattgt ccttaatttt ttacaaatca
     9661 acttggtttt ggagagtttt caatcacctc gcaaagccct atctaccagc aagtcgtgaa
     9721 ttttttcaga ttctgctttt gatggagagc ggagttcttt tcttagcggt catctatcta
     9781 ctggtttttg caggaaagaa aatttttcat ttcaagtggc agctgaggta cttcatctac
     9841 cttttactgg gctacatcat ttcatatatg tctgacttcc tcttttcgta tttcatatcc
     9901 ctgtcttcaa atcagatttc tttgaatgaa acggtagaaa tgatggggag acaggagttc
     9961 ccttatttct tgctcatcgt ttgcttcatc gcccctattg ctgaggaatt gatttatcga
    10021 ggtgtgctta tgacaacctt tttcaaaaac tcaccttggt acggagatgt tttgctttct
    10081 gctattattt tcggttatat tcatatcaat tttgctttaa ctcctcttgc ttttttcatt
    10141 tatgctagtg gaggtcttat tttagctcta ttgtatcgca tgactaaaaa tctctactat
    10201 ccaatactag ttcatattct catcaatatc actgccttct gggatgtttg gttactccta
    10261 ttttcaggaa gttagcttac taaaaaaatg tcggaatttt ccggcatttt cttttttcac
    10321 aaatagtcaa cgtttttctt tccgatactg aagtggtgtg tagccactta tttttttgaa
    10381 ttgattttga aaataagatt ggcgtgagaa aggcagatag tgaagatagt taagaagaat
    10441 aggatgttct tttttccttt ttggaaaact tctaaaatat ggtataatga aaagataaag
    10501 aagttggggg tagaagatga acattcaaca attacgctat gttgtggcta ttgccaatag
    10561 tggtactttt cgtgaagctg ctgaaaagat gtatgttagt cagccgagtc tgtctatttc
    10621 tgttcgtgat ttggaaaaag agttgggctt taagattttc cgtcggacca gctcagggac
    10681 tttcttgacc cgtcgtggga tggaatttta tgaaaaagcg caagaattgg ttaaaggatt
    10741 tgatattttt caaaatcagt atgccaatcc tgaagaagaa aaagatgaat tttccgttgc
    10801 tagccagcac tatgacttct taccaccaac tattacggcc ttttcagagc gctatcctga
    10861 ctataagaac ttccgtattt ttgaatcaac tactgttcaa atattagatg aagtggcgca
    10921 agggcatagt gagattggga ttatctacct caacaatcaa aataaaaagg ggattatgca
    10981 acgggttgaa aagttaggtc tggaggtcat cgaattgatt cctttccata cccatattta
    11041 tctctgtgag ggtcatcctt tagctcagaa agaggaatta gtcatggagg atttagcgga
    11101 tttaccaacg gttcgtttca ctcaagagaa agacgagtac ctttattatt cagagaactt
    11161 tgtcgatacc agcgctagct cacagatgtt taatgtgaca gaccgtgcca ccttgaatgg
    11221 tattttggag cggacggacg cctatgcgac aggttctgga tttttagata gtgacagtgt
    11281 taatggcatt acagttattc gtctcaagga taacctagat aaccgcatgg tctatgttaa
    11341 acgtgaagaa gtggagctta gtcaagctgg gactctcttc gtagaagtca tgcaagaata
    11401 ttttgatcaa aagaggaaat catgaaaaaa agagcaatag tggcagtcat tgtactgctt
    11461 ttaattgggc tggatcagtt ggtcaaatcc tatatcgtcc agcagattcc actgggtgaa
    11521 gtgcgctcct ggattcccaa tttcgttagc ttgacctacc tgcaaaatcg aggtgcagcc
    11581 ttttctatct tacaagatca gcagctgtta ttcgctgtca ttactctggt tgtcgtgata
    11641 ggtgccattt ggtatttaca taaacacatg gaggactcat tctggatggt attgggtttg
    11701 actctaataa tcgcgggtgg tcttggaaac tttattgaca gggtcagtca gggctttgtt
    11761 gtggatatgt tccaccttga ctttatcaac tttgcaattt tcaatgtggc agatagctat
    11821 ctgacggttg gagtgattat tttattgatt gcaatgctaa aagaggaaat aaatggaaat
    11881 taaaattgaa actggtggtc tgcgtttgga taaggctttg tcagatttgt cagaattatc
    11941 acgtagtctc gcgaatgaac aaattaaatc aggccaggtc ttggtcaatg gtcaagtcaa
    12001 gaaagctaaa tacacagtcc aagagggtga tgtcgtcact taccatgtgc cagaaccaga
    12061 ggtattagag tatgtggctg aggatcttcc gctagaaata gtctaccaag atgaggatgt
    12121 ggctgtcgtt aacaaacctc agggaatggt tgtgcacccg agtgctggtc ataccagtgg
    12181 aaccctagta aatgccctca tgtatcatat taaggacttg tcgggtatca atggggttct
    12241 gcgtccaggg attgttcacc gtattgataa ggatacgtca ggtcttctca tgattgctaa
    12301 aaacgatgat gcgcatctag cacttgccca agaactcaag gataaaaagt ctctccgcaa
    12361 atattgggcg attgttcatg gaaatctgcc taatgatcgt ggtgtaattg aagcgccgat
    12421 tggccggagt gaaaaagacc gtaagaaaca ggctgtaact gctaaaggga agcctgcagt
    12481 gacgcgtttt cacgtcttgg aacgctttgg cgattatagc ttagtagagt tgcaactgga
    12541 gacagggcgc actcatcaaa tccgtgtcca catggcttat atcggccatt cagtcgctgg
    12601 tgatgaggtc tatggtcctc gcaagacttt gaaaggacat ggacaatttc ttcatgccaa
    12661 gactttaggt tttactcatc cgagaacagg taagaccttg gaatttaaag cagatatccc
    12721 agagattttt aaggaaacct tggagagatt gagaaagtaa gaatgaaaaa gaaattaact
    12781 agtttagcac ttgtaggcgc ttttttaggt ttgtcatggt atgggaatgt tcaggctcaa
    12841 gaaagttcag gaaataaaat ccactttatc aatgttcaag aaggtggcag tgatgcgatt
    12901 attcttgaaa gcaatggaca ttttgccatg gtggatacag gagaagatta tgatttccca
    12961 gatggaagtg attctcgcta tccatggaga gaaggaattg aaacgtctta taagcatgtt
    13021 ctaacagacc gtgtctttcg tcgtttgaag gaattgggtg tccaaaaact tgattttatt
    13081 ttggtgaccc atacccacag tgatcatatt ggaaatgttg atgaattact gtctacctat
    13141 ccagttgacc gagtctatct taaaaaatat agtgataatc gtattactaa ttctgaacgt
    13201 ctatgggata atctgtacgg ttatgataag gttttacaga ctgcttcaga aaaaggtgtt
    13261 tcagttattc aaaatatcac acaaggggat gctcattttc agtttgggga catggatatt
    13321 gagctctata actatgaaaa tgaaaccgat tcatcgggtg aattaaagaa aatttgggat
    13381 gacaattcca attccttgat tagcgtggtg aaagtcaatg gcaagaaaat ttaccttggg
    13441 ggcgatttag ataatgttca tggagcagaa gacaagtatg gtcctctcat tggaaaagtt
    13501 gatttgatga agtttaatca tcaccatgat accaacaaat caaataccaa ggatttcatt
    13561 aaaaatttga gtccgagttt gattgttcaa acttcggata gtctaccttg gaaaaatggt
    13621 gttgatagtg agtatgttaa ttggctcaaa gaacgaggaa ttgagagaat caacgcagcc
    13681 agcaaagact atgatgcaac agtttttgat attcgacaag acggtttagt aaacatttca
    13741 acttcctaca agccgattcc aagttttcaa gctggttggc ataagagttc atatggaaac
    13801 tggtggtatc aagcgcctga ttctacagga gaatatgctg tcggttggaa tgaaattaag
    13861 ggtgaatggt attactttaa ccaaacgggt atcttattac agaatcaatg gaaaaaatgg
    13921 aacaatcgtt ggttctattt gacagactct ggtgttgctg ctaaaaattg gaagaaaatc
    13981 gctggaatct ggtattattt taacaaagaa aaccagatgg aaattggttg gattcaagat
    14041 aaagagcagt ggtattattt ggatgttgat ggctctatga agacaggttg gcttcaatat
    14101 aaggggcaat ggtattactt tgctccatca ggggaaatga aaacgggctg ggtaaaagat
    14161 aaagaagcct ggtactatat ggattctact ggtatcatga agacaggtga gatagaagtt
    14221 gctggacatc attactatct agaagaatca ggagctatga agcaaggctg gcttaaaaag
    14281 gcaaatgatt ggtatttcta caagacagat ggttcacgag ctataggttg gattaaagac
    14341 aaggataaat ggtacttctt gaaagaaaat ggtcaattac ttgtgaatgg taagacacca
    14401 gaaggctata ctgtggattc aagtggtgcc tggttagtgg atgttccgat cgagaaatct
    14461 gctacaatta aaactacaag tcattcagaa ataaaagaat ccaaagaagt agtgaaaaag
    14521 gatcttgaaa ataaagaaac gagtcaacat gaaagtgtta caaattcttc aactagtcaa
    14581 gatttgacat cctcaacttc acaaagctct gaaacgagtg taaacaaatc ggaatcagaa
    14641 cagtagtaga aaagaaggtt ttagggcctt ctttttccta tcaactcttt tctatttcct
    14701 gttattcatg ttataatgga taaatatgaa taatcggagt gagactatga aatacaaacg
    14761 gattgtcttt aaggtgggta cttcttctct gacaaatgag gatggaagtt tatcacgtag
    14821 taaggtaaag gatattaccc agcagttggc tatgctgcac gaggctggtc atgagttgat
    14881 tttggtgtct tcaggtgcca ttgcggctgg ttttggagcc ttaggattta aaaagcgtcc
    14941 gactaaaatt gctgataaac aggcttcagc agcggtaggg cagggacttt tgttggaaga
    15001 atatacgacc aatcttctct tgcgtcaaat cgtttctgca caaatcttgc tgacccaaga
    15061 tgactttgtg gataagcgtc gttataaaaa tgcccatcag gctttgtcgg ttttgctcaa
    15121 ccgtggggca attcctatca tcaatgagaa tgatagtgtc gttattgatg agctcaaggt
    15181 tggggacaat gacactctaa gtgctcaagt agcggcgatg gtccaagcag accttttagt
    15241 tttcttgaca gatgtggacg gtctctatac tggaaatcct aattcagatc caagagccaa
    15301 acgcttggag agaatcgaga ccatcaatcg tgagattatt gatatggctg gtggagcagg
    15361 ttcgtcaaac ggaactgggg gtatgttaac caaaatcaag gctgcaacta tcgcgacgga
    15421 atcaggagtt cctgtttata tctgctcatc cttgaaatca gattccatga ttgaggcggc
    15481 agaggagacc gaggatggtt cttactttgt tgctcaagag aaggggcttc gtacccagaa
    15541 acaatggctt gccttctatg ctcagagtca aggttctatt tgggttgata aaggggctgc
    15601 ggaagctctc tctcaacatg gaaagagtct tctcttatct ggtatcgttg aagcagaagg
    15661 agccttttct tacggtgata tcgtgacagt atttgacaag gaaagtggaa aatcacttgg
    15721 aaaaggacgc gtgcaatttg gagcatctgc tttggaggat atgttgcgtt ctcaaaaagc
    15781 caagggtgtc ttgatttacc gtgacgactg gatttccatt actcctgaaa tccaactact
    15841 ttttacagaa ttttagaggt aaactatggt gagtagacaa gaacaatttg aacaggtaca
    15901 ggctgttaaa aaatcgatta acacagctag tgaagaagtg aaaaaccaag ccttgctagc
    15961 catggctgat cacttagtgg ctgctactga ggaaatttta gcggctaatg ccctcgatat
    16021 ggcagcggct aaggggaaaa tctcagatgt gatgttggat cgtctttatt tggatgcaga
    16081 tcgtatagaa gcgatggcaa gaggaattcg tgaagtggtt gccttaccag atccaatcgg
    16141 tgaagtttta gaaacaagtc agcttgaaaa tggtttggtt atcacaaaaa aacgtgtagc
    16201 tatgggtgtc atcggtatta tctatgaaag ccgtccaaat gtgacgtctg atgcggctgc
    16261 tttgactctt aagagtggaa atgcggttgt tcttcgtagt ggtaaggatg cctatcaaac
    16321 aacccatgcc attgtcacag ccttgaagaa gggcttggag acgactacta ttcatccaaa
    16381 tgtgattcaa ctggtggagg atactagccg tgaaagtagt tatgctatga tgaaggccaa
    16441 gggctatcta gaccttctca ttcctcgtgg aggagctggc ttgatcaatg cagtggttga
    16501 gaatgcgatt gtacctgtta tcgagacagg gactgggatt gtccatgtct atgtggataa
    16561 ggatgcagac gaagacaagg cgctgtctat catcaacaat gctaaaacca gtcgtccttc
    16621 tgtttgtaat gccatggagg ttctgctggt tcatgaaaac aaggcagcaa gcatccttcc
    16681 tcgcttggat caaatgctgg ttgcagagcg taaggaagct ggactggaac caattcaatt
    16741 ccgcttggat agcaaagcaa gccagtttgt ttcaggtcaa gcagctgaga cccaagactt
    16801 tgacaccgag tttttagact atgtccttgc tgttaaggtt gtgagcagtt tagaagaagc
    16861 ggttgcgcac attgaatccc acagcaccca tcattcggat gctattgtga cggaaaatgc
    16921 tgaagctgca gcatacttta cagatcaagt ggactctgca gcggtgtatg ttaatgcctc
    16981 aactcgtttc acagatggag gacaatttgg tcttggttgt gaaatgggga tttctactca
    17041 gaaattgcac gcgcgtggtc caatgggctt gaaagagttg accagctaca agtatgtggt
    17101 tgctggtgat gggcagataa gggagtaaga gatgaagatt ggatttatcg gtttggggaa
    17161 tatgggtgct agcttggcaa aatctgtctt gcagactagg acgtcagatg agattctcct
    17221 tgccaatcgt agtcaagcta aggtagatgc tttcattgca gactttggtg gtcaggcttc
    17281 cagcaatgaa gaaatgtttg cagaagcaga tgtgattttt ctaggagtta agcctgctca
    17341 gttttctgaa ctgctttctc aataccagac catccttgaa aaaagagaaa gtcttctttt
    17401 gatttcgatg gcagctggat tgaccttaga aaaactagca agtcttatcc caagtcaaca
    17461 ccgaattatt cgtatgatgc ctaatacccc tgcttctatc gggcaaggag tgattagtta
    17521 tgccttgtct cctaattgca gggctgagga cagtgagctc ttttgtcagc ttttatccaa
    17581 ggctggtctc ttggttgaat taggagaaag cttaatcaat gcagcgacag gtcttgcagg
    17641 ctgtggacca gcctttgtct atctctttat tgaagccttg gcagatgcag gtgttcagac
    17701 gggattatca cgagaaacag ccttgaaaat ggcagcccaa actgtggtag gagctgggca
    17761 attggtccta gaaagccagc aacatcctgg agttttgaaa gatcaagttt gtagtccagg
    17821 cggttcgact attgctggcg tagcaagcct agaagcgcat gcttttcgag gcacagtcat
    17881 ggaggcagtt catcaagcct ataaacgaac acaagaacta ggtaaataag aggtagcttt
    17941 atctgcctct tttatggtgg ttgatactct tcgaaaatca aattcaaact gcgtcagctt
    18001 caccttgccg tactcaagta cagcctgcgg ctagcttcct agtttgctct ttgattttca
    18061 ttgagtatga aatgagaaga caaaaagatt gtcacaaacc cctatttttt tgatagaata
    18121 gaagtagtaa aaaagaaatg agttagacat gtcaaaagga tttttagtct ctcttgaggg
    18181 accagaggga gcaggcaaga ccagtgtttt agaggctctg ctaccaattt tagaggaaaa
    18241 aggagtagag gtgttgacga cccgtgaacc tggcggagtc ttgattgggg agaagattcg
    18301 ggaagtgatt ttggatccaa gtcatactca gatggatgct aaaacagagc tacttctcta
    18361 tattgccagt cgcagacagc atttggtgga aaaagttctt ccagcccttg aagctggcaa
    18421 gttggtcatc atggatcgtt ttatcgatag ttctgttgcc tatcagggat ttggtcgtgg
    18481 cttagatatt gaagccattg actggctcaa tcagtttgcg acagatggcc tcaaacccga
    18541 tttgacactc tattttgaca tcgaggtgga agaagggctg gctcgtattg ctgctaatag
    18601 tgaccgcgag gttaatcgtt tggatttgga agggttggac ttgcataaaa aagttcgtca
    18661 aggctacctt tctcttctgg ataaagaggg aaatcgcatt gtcaagattg atgctagtct
    18721 ccctttggag caagttgtgg aaactaccaa gtctgtcttg tttgacggaa tgggcttggc
    18781 caaatgaaac aagatcaact aaaggcttgg caaccagctc agtttgaccg ttttgtccgt
    18841 atcttagaac aagaccagct caatcacgcc tatctctttt caggtttctt tggaagcttg
    18901 gaaatagcgc aatttttagc taagagcctc ttttgtacgg ataaagttgg cgtcttacca
    18961 tgtgagaaat gccgaagttg caagctgatt gaacaggaag agtttccaga tgtcaccttg
    19021 attaagccag tcaatcaggt catcaagaca gaacgcattc gggaattggt gggacagttt
    19081 tctcaagcag ggattgaaag ccagcaacag gtctttatca tcgagcaagc ggataaaatg
    19141 catcccaacg cagccaattc tctgctcaag gtcatcgaag aaccccagag tgaagtttat
    19201 attttcttct tgactagcga tgaggaaaag atgttaccga caatccgaag tcggacccag
    19261 atcttccact ttaaaaagca agaagaaaaa cttatcttac tcttagaaca aatgggactt
    19321 gttaagaaaa aagcgactct tttagctaag tttagtcaat cgcgagctga agcagaaaag
    19381 ttggctaatc aggcaagttt ttggaccttg gtcgatgaaa gtgaacgcct gctgacttgg
    19441 ttagtagcta agaaaaaaga aagttatcta caggttgcca aattagccaa cttggcagat
    19501 gataaggaaa aacaggatca ggttttacgg attcttgaag ttctctgtgg gcaggacctc
    19561 ttgcaggtaa gagtaagagt gattctacaa gatttactag aagctagaaa aatgtggcaa
    19621 gctaatgtca gctttcaaaa tgccatggaa tatctggtct tgaaagaaat ataaactcaa
    19681 aaatgaatga taaagaaagg aaagggctgt tttatggaca aaaaagaatt atttgacgcg
    19741 ctggatgatt tttcccaaca attattggta accttagccg atgtggaagc catcaagaaa
    19801 aatctcaaga gcttggtaga agaaaataca gctcttcgct tggaaaatag taagttgcga
    19861 gaacgcttgg gtgaggtgga agcagacgct cccgtcaagg ccaagcatgt tcgcgaaagt
    19921 gtccgtcgta tttaccgtga tggatttcac gtatgtaatg atttttatgg acaacgtcga
    19981 gagcaggacg aagaatgtat gttctgtgat gagttgttat acagggagta agcatgcaaa
    20041 ttcaaaaaag ttttaagggg cagtctccct atggcaagct gtatctagtg gcaacgccga
    20101 ttggcaatct agatgatatg acttttcgtg ctatccagac cttgaaagaa gtggactgga
    20161 ttgctgctga ggatacgcgc aatacagggc ttttgctcaa gcattttgac atttccacca
    20221 agcagatcag ttttcatgag cacaatgcca aggaaaaaat tcctgatttg attggtttct
    20281 tgaaagcagg gcaaagtatt gctcaggtct ctgatgccgg tttgcctagc atttcagacc
    20341 ctggtcatga tttggttaag gcagctattg aggaagaaat tgcagttgtt acagttccag
    20401 gtgcctctgc aggaatttcc gccttgattg ccagtggttt agcgccgcag ccacatatct
    20461 tttacggctt tttaccgaga aaatcaggcc agcaaaagca atttttcgac tcgaaaaaag
    20521 actatcctga aactcagatt ttttatgaat cgccccatcg tgtggcagat acattggaaa
    20581 atatgctaga agtttacggt gaccgctcgg tagtcttggt cagggaattg actaaaatct
    20641 atgaagaata ccaaagaggt accatttctg aattgctgga aagcatctct gaaacgtctc
    20701 tcaagggtga atgccttctt attgttgaag gtgccagtca ggatgtggag gaaaaagacg
    20761 aggaggactt gttcttagaa atccaagccc gcatccaaca tggtatgaag aaaaatcaag
    20821 ccattaagga agttgcgaaa tactaccagt ggaataaaag tcagctttat gctgcctacc
    20881 acgaatggga agaaaatcaa gaaaatgact aaacagggaa gtttgccttc ttcccttttt
    20941 ttgttatact agtagaagaa aaaaatagaa agatttgtgg gagtgaaaaa gtcctgtgga
    21001 ctttttcagc ctgagccaag aaactcgaaa gctcgtaagt ctgattggct ttttcaatgt
    21061 gaatcttaac ttcacactcc caaagaggta ttagtgtcgt gtctcaatct tatatcaatg
    21121 ttatcggtgc tggtttggca ggttctgaag cagcttacca aatcgcagag cgtggtattc
    21181 cagttaaact ttatgaaatg cgtggtgtca agtcgactcc tcagcataaa acagacaatt
    21241 ttgctgagtt ggtttgttcc aattctttgc gtggggatgc tttgacaaat gcagttggtc
    21301 ttctcaagga agaaatgcgt cgcttgggtt ctgttatctt ggaatctgct gaggctacac
    21361 gtgttcctgc cggtggagcc cttgcggtgg atcgtgatgg tttctcccaa atggtaaccg
    21421 aaaaagtggt caaccacccc ttgattgaag tggtgcgtga tgaaattaca gaattgccaa
    21481 cagatgttat tacagttgtg gcgaccggtc ccttgactag cgatgccctg gctgaaaaga
    21541 ttcatgccct taatgatggc gatggcttct atttctacga tgcagcagcg cctattatcg
    21601 atgtcaacac tatcgatatg agtaaggtct atctcaaatc tcgttatgat aagggagaag
    21661 cagcctatct caatgctcca atgaccaagc aagagtttat ggatttccat gaagccttgg
    21721 tcaatgcgga agaagcaccg ctcaattctt ttgaaaaaga aaagtacttt gaaggatgta
    21781 tgccaatcga agttatggcc aaacgtggca ttaaaactat gctttatggc cctatgaagc
    21841 cagtcggtct tgagtatccg gacgactaca caggacctcg tgatggagaa tttaaaacac
    21901 cttatgcggt tgtgcaactt cgtcaggata atgcagctgg tagcctctac aatatcgttg
    21961 gtttccagac ccacctcaaa tggggagaac aaaagcgtgt cttccaaatg attccgagtc
    22021 ttgaaaatgc ggagtttgtc cgttatggtg tcatgcatcg caattcttac atggattcac
    22081 caaatcttct tgagcagact taccgttcta agaaacaacc aaatctcttc tttgctggtc
    22141 agatgacggg ggtggaaggc tatgttgagt cggcggcttc aggcttagtt gcgggaatta
    22201 acgcagctcg tctcttcaag gaagaaagcg aggctatttt ccccgatacg acagcgattg
    22261 gaagcttagc tcattacatt acccatgccg acagcaaaca tttccaacca atgaatgtca
    22321 attttgggat catcaaggag ttggaaggcg agcgtatccg tgataagaag gctcgttatg
    22381 aaaaaattgc agagcgtgcc cttgccgact tagaggaatt tttgactgtc taattttttt
    22441 gaaagaattg ctcatgatac tataaaaatc ttagaaattg tgataaaata ggtaggatga
    22501 aagaaggaga gtgaaaatgg cgaatcccaa gtataaacgt attttaatca agttatcagg
    22561 tgaagccctt gccggtgaac gtggcgtagg gattgatatc caaacagttc aaacaatcgc
    22621 aaaagagatt caagaagttc atagcttagg tatcgaaatt gcccttgtta ttggtggagg
    22681 aaatctctgg cgtggagaac ctgcagcaga agcaggtatg gaccgtgttc aggcagatta
    22741 cactggaatg cttgggactg ttatgaatgc tcttgtgatg gcagattcat tgcaacaagt
    22801 tggggttgat acgcgtgtac aaacagctat tgccatgcaa caagtggcag agccttatgt
    22861 ccgtggacgt gcccttcgtc accttgaaaa aggccgtatc gttatctttg gtgctggaat
    22921 tggttcacca tacttctcga cagatacaac agcggccctt cgtgcagctg aaatcgaagc
    22981 agatgccatc ctcatggcta aaaatggcgt cgatggtgtg tacaatgccg atcctaagaa
    23041 ggacaagaca gccgttaagt ttgaagaatt gacccaccgt gatgttatca acaaaggtct
    23101 tcgtatcatg gactcaacag cctcaaccct ctcaatggac aacgacattg acttggttgt
    23161 cttcaacatg aaccaatcag gcaacatcaa acgtgtcgta tttggtgaaa atatcggaac
    23221 aacagtttca aataatatcg aagaaaagga ataagaaaga atatggctaa cgtaattatt
    23281 gaaaaagcta aagagagaat gacccagtct caccaatcac ttgctcgtga atttggtggt
    23341 atccgtgctg gtcgtgccaa tgcaagcttg cttgaccgtg tacatgtaga atactatgga
    23401 gtcgaaactc ctcttaacca aatcgcttca attacgattc cagaagcgcg tgttttgttg
    23461 gtaacaccat ttgacaagtc ttcattgaaa gacatcgaac gtgccttgaa cgcttctgat
    23521 cttggtatca caccggctaa tgacggttct gtgattcgct tggttatccc agctcttaca
    23581 gaagaaactc gtcgtgacct tgctaaagaa gtgaagaagg tcggcgaaaa tgctaaagtg
    23641 gctgtccgca atatccgtcg cgatgctatg gacgaagcta agaaacaaga aaaagcaaaa
    23701 gaaatcactg aagacgaatt gaagactctt gaaaaagata ttcaaaaagt aacagacgat
    23761 gctgttaaac acatcgacga catgactgct aacaaagaga aagaactttt ggaagtctaa
    23821 aaataaacag aaaaactcag ttggcattgc tggctgagtt ttattcgaaa gaaggaaata
    23881 tgaatacaaa tcttgcaagt tttatcgttg gactgatcat cgatgaaaat gaccgttttt
    23941 actttgtgca aaaggatggt caaacctatg ctcttgctaa ggaagagggc caacatacag
    24001 taggggatac ggtcaaaggt tttgcataca cggatatgaa gcaaaaactc cgcctgacaa
    24061 ccttagaagt gactgccact caggaccaat ttggttgggg acgtgtcaca gaggttcgta
    24121 aggacttggg tgtctttgtg gatacaggcc ttcctgacaa ggaaatcgtt gtgtcactcg
    24181 atattctccc tgagctcaag gaactctggc ctaagaaggg cgaccaactc tacatccgtc
    24241 ttgaagtgga taagaaagac cgtatctggg gcctcttggc ttatcaagaa gactttcaac
    24301 gtctcgctcg tcctgcttac aacaacatgc agaaccaaaa ctggccagcc attgtttacc
    24361 gtctcaagct gtcaggaact tttgtttacc taccagaaaa taatatgctt ggttttattc
    24421 atcctagcga gcgttacgca gagccacgtt tggggcaagt attagatgcg cgcgttattg
    24481 gtttccgtga agtggacctc actctgaacc tctccctcaa accacgctcc tttgaaatgt
    24541 tggaaaacga tgctcagatg attttgactt atttggaaag caatggcggt ttcatgacct
    24601 taaatgataa gtcatctcca gacgacatca aggcaacctt tggcatttct aaaggtcagt
    24661 tcaagaaagc tttaggtggt cttatgaagg ctggtaaaat caagcaagac cagtttggga
    24721 cagagttgat ttagggagat ttatgagaaa atcattttac acttggctca tgaccgagcg
    24781 caatcctaaa agtaacagtc ccaaagctat cttggcagac ctcgcttttg aagaggcagc
    24841 ttttccaaaa cacacagatg attttgatga ggtcagtcgc tttttggagg agcatgccag
    24901 tttctctttt aacctaggag actttgacgc tatctggcaa gaatacttag aacactagca
    24961 tttattcact aggtttgggc tagtaatttc tccatccctc tgctataata aaaagaaata
    25021 aaaggattag agaggttctt tatttgaagg aacattcaat agacattcaa ctgagtcatc
    25081 cagatgactt gtttcatctt tttggttcca atgaacgcca tcttcgtttg atggaagaag
    25141 agctggatgt ggtgattcat gctcgtacgg agattgtcca ggttttggga gaagagactg
    25201 cctgtgagga agcccgtcag gttatccaag ctttgatggt cttggtgaac cgtgggatga
    25261 ccgttggtac gccagatgtg gtgactgcaa ttagcatggt caaaaacgat gaaattgata
    25321 agtttgtcgc cctttacgaa gaagaaatta tcaaggataa tactgggaaa ccgatccgcg
    25381 ttaaaacgtt aggtcaaaaa ctttatgtgg acagtgtcaa acagcatgat gtgacctttg
    25441 gaattgggcc tgcagggacg gggaagacct ttcttgcagt tactttggca gtgactgccc
    25501 ttaaacgtgg gcaagtcaag cggattatct tgacacgtcc agcggtggaa gcaggagaga
    25561 gtctaggttt tcttccgggt gatcttaagg agaaggtaga tccttacctt agacctgttt
    25621 atgatgcctt gtatcagatt ctggggaaag accaaacaac tcgactcatg gagcgtgaaa
    25681 ttatcgagat tgcgcccctt gcctatatgc gtggacggac cttggatgat gcctttgtca
    25741 ttctcgatga ggcgcaaaat acgaccatca tgcagatgaa gatgttcttg actcgtttag
    25801 gttttcattc taagatgatt gtcaatggag atattagtca gattgacctg ccacgtaatg
    25861 tcaagtccgg tttgattgat gctcaagaga aactcaagaa catccatcag attgactttg
    25921 ttcatttttc agccaaggat gtggttcgcc atccagttgt cgctcagatt atccgagcct
    25981 atgaatattc tactgaagtt gcacacgact gattttgagg aagttcgcct gcaaaagaat
    26041 atacttttga gagaggaaaa tccagttgta taggctaaag gttttatcca aaggtttgag
    26101 acaacgatta ggcacgatgg aaagaacttt tatgtggctg atgacgatca gtgcatcttc
    26161 ctgtgtcata atcacagggc acaagaaagt aggaatttga aaagatgatt gaccaactat
    26221 ctaagtatta cagttgtagg atactaactg aaaaggatat tccaagtatt ttatctttat
    26281 atgaaagtaa tcctctgtat tttcagcatt gtccaccaga gccaaatttt gcaactgtaa
    26341 aagaggacat gctttgtcta cctgaaggta aagctaaggc tgataagttt tttgttggat
    26401 tttggaatgg atctgacctt gtggctgtta tggattttgt ctatgcatat cctgatgagg
    26461 agactgtttt tattggtttg tttatggttg atcaagccta tcagaggaaa gggattggta
    26521 gtcatattgt gacagaagca ctagcttatt ttgctaagaa ctgtcgaaag gcacgtttgg
    26581 cttatgttaa gggaaatccg caatctcagc atttttggga aaagcagggc tttaaatcaa
    26641 ttggatgcga ggttaagcaa gaactctata cggttgttat cgctgaacag agcctagaag
    26701 attagaaatg gcatcaagta agaactattt ggaatttgtt ttggaacaat tatcaggatt
    26761 agatgatgtg acttaccgtt ccatgatggg ggagtatatt ctttacttcc gcggcaagat
    26821 tattggcggc atttatgacg atcgcttttt agttaaaccc gtgcaagcag tcttagataa
    26881 gattgaccaa tcttcttttg agtttccata caaaggtgcc aaagaaatga tttgagtgga
    26941 agaacttgat aataagatgt ttctataaga cctgatttta gctatgtata accaactgcc
    27001 aacgcccaaa cctaaaaaga aaaagcaagg gtgaacgaag taaaaaagaa gtctgctaag
    27061 gccctgtctt tgcacgggta aaattttata tataaaaaga agctgggact aaagagctca
    27121 gcttcctttg gtttatataa ttgtcattac aagacgaagt ggttgggcga aactctgttg
    27181 attttattca atttagagtt tcttatgcac aattgagtct ggaacgaaag tctccagttg
    27241 caaagtatac agtacaataa accaacgatg taatagctga tgacacaaag cacagtgggt
    27301 aggacttgcg aagtcaccct tttcttttca aaatttatac taaatcattg atatcagtgt
    27361 agtcacgatt aagtccttga gcaactggta ggctagttaa gtaaccttga taagtggtca
    27421 caccttgacg caagccttca tcttcagaga ttgcttgtgc gaatcctttg ccagccaaag
    27481 cttcgatata aggaagagtg acattggtta gggcgatggt tgaagtgcga gcaaccgcac
    27541 cagggatatt ggcaacggca tagtggagaa caccgtgttt ttcatagacg ggttcatcgt
    27601 gcgttgtcac acggtcagct gtttcgataa cgccaccttg gtcaacagca acgtcaacga
    27661 tacagagcct ggacgcattt gtttgaccat ctcatctgtc accaattccg gtgcttttgc
    27721 accagggatg agaatggctc caatcaccac atcagcatct ctcacacttg cttcaatgtt
    27781 gaatgaatta gatataagag tttgaatttg acttccaaag acttcttcta gaactgagag
    27841 acgcttggca ctaatatcta aaatagtcac ttgagcacca agaccaaggg cgatgcgggc
    27901 agcatgtgta ccgacgacac catcaccgat gatagttact tttccttttg gaacacctgg
    27961 tacaccacca ggtagaacac cagatccacc agcttgctta gtaaggaagt gagctccgat
    28021 ttaaacagcc atacgatctg caacctcact cataggaacg aggagcggta gttgtccttg
    28081 attgtcacga acagtttcat aggcaattcc tgttgttttt gctgctaaca tagcatctgc
    28141 taattctgga gcagcggcca tgtgcaagta ggtgaagaga agaagatcgt cgcgcaagta
    28201 accgtattca gaacttaaag gttcttttac tttcacaacc aactctgctg cccaagcttc
    28261 accagcagta gcgacaatct cagctccttg cttttgatag tcagcatcag taaagccaga
    28321 accgagacca gcatttgttt cgataaggac acgatgacca cgactaacta agctatgaac
    28381 acctgcaggt gtgagggcga cacggttttc gttattttta atttcttttg ggattccgat
    28441 taacattgag ataacctacc tttcaattga cggtcttgtt ttggttgtca cattccagtt
    28501 cataaatcaa aaatgtgacg gtttcattgt atatgaaacc gcttcaaaaa tcaagaaaaa
    28561 cttgtcatcc aaatttttta tgctagacta gtgaaaatca agctttgatt ggttggaaaa
    28621 gtatggaatc aatttttgta aaacttgccc agtatccgtc tatagaaacg gagcgtttat
    28681 tgcttagacc tgtaactttg gatgatgcgg aagcaatgtt tgactatgcc tcggacaagg
    28741 gtaatacacg ttacactttt ccaaccaatc aaagcttgga agaaaccaag aataacattg
    28801 ctcagttcta tttggctaat cccttgggac gttggggaat agaactaaaa agcaatggtc
    28861 agtttattgg aaccattgac ttgcacaaga ttgattctgt tcttaagaag gcagctattg
    28921 gctacattat caataaaaag tattggaatc aaggattaac gacagaagcc aatcgtgctg
    28981 tgattgagct agcttttgag aagataggga tgaataagtt gactgccctt cacgataagg
    29041 acaatcctgc gtcaggaaag gtcatggaga aatcaggcat gcgtttttcc catgcagaac
    29101 catatgcttg tatggaccag catgaaaaag atcgaatcgt tacaagagtt cattatgtct
    29161 tgaccaagga agactatttt gcaaataaat aagcagttga aaagaaattt ttcgactgtt
    29221 ttttcttcct cttacgaata atctaagaga ggagaaaata tggaagcaat tatcgagaaa
    29281 atcaaagagt ataaaatcat cgtcatctgt actggtctgg gcttgcttgt aggcggattt
    29341 ttcctgctaa agccagctcc acaaacacct gtaaaggaaa cgaatttgca ggctgaagtt
    29401 gcagctgttt ccaaggattt ggtatccgaa aaggaagtga acaaggaaga gaaggaagaa
    29461 ccagttgaac aagatctaat cacagtagat gtcaaaggtg ctgtcaaatc gccagggatt
    29521 tatgacttgc ctgtaggtag tcgagtcaat gatgctgttc agaaggctgg tggcttgaca
    29581 gagcaagcag acagcaagtc gctcaatcta gctcagaaag ttagtgatga ggctctggtt
    29641 tacgttccta ctaagggaga agaagcagtt agtcaacaga ctggttcggg gacagcttct
    29701 tcaataagca aggaaaagaa ggtcaatctc aacaaggcca gtctggaaga actcaagcag
    29761 gtcaagggac tgggaggaaa acgagctcag gacattatcg accatcgtga ggcaaatggc
    29821 aagttcaagt cagtagacga gctcaagaag gtctctggca ttggtggcaa aacaatagaa
    29881 aagcttaaag actatgttac agtggattaa gaatttctct attcccctaa tttacctgag
    29941 ttttctatta ctttggcttt attacgctat tttctcagca tcttatcttg ctttgttggg
    30001 ctttgttttt ctgctagtct gtctctttat ccaatttccg tggaaatctg ctggtaaagt
    30061 tctaataatt tgcggaatct ttggattttg gtttgttttt caaaattggc aacagagtca
    30121 agcgagtcaa aatctggcgg attctgttga aagggtacgg attttgcctg atactattaa
    30181 ggttaatggt gatagtctat cctttcgtgg caagtctaac ggtcgtgctt tccaagtcta
    30241 ttataaactc cagtccgagg aggagaaaga agcctttcaa gctttaaccg acctgcatga
    30301 gataggacta gaagggaagc tttcggagcc agaagggcag agaaattttg gtggctttaa
    30361 ttaccaagcc tatctgaaga ctcagggaat ttaccagact ctcaatatca aaacaatcca
    30421 gtcacttcaa aagattggca gttgggatat aggagaaaac ttgtccagtt tacgtcgaaa
    30481 ggctgtggtt tggattaaga cgcactttcc agaccctatg cgcaattaca tgacaggact
    30541 cttgctggga catctggaca ccgactttga ggagatgaat gagctttatt ccagtctagg
    30601 aattatccac ctctttgccc tatctggtat gcaggtaggt tttttcatga atggatttaa
    30661 gaaacttctc ttgcgattgg gcttgaccca agaaaagttg aaatggctga cttatccctt
    30721 ttcccttatc tatgcgggac taactggatt ttcagcatcg gttattcgca gtctcttgca
    30781 aaagctactg gctcaacatg gggttaaggg cttggataat tttgccttga cggtgcttgt
    30841 cctctttatt gtcatgccaa actttttctt gacagcagga ggagtcttgt cctgcgctta
    30901 tgcttttatc ctgaccatga ccagcaaaga aggggagggg ctcaaggctg ttactagtga
    30961 aagtctagtc atctccttgg gcatattgcc cattctatcc ttctattttg cggaatttca
    31021 accttggtct atccttttga cctttgtctt ttcctttcta tttgacttga ccttcttacc
    31081 gctcttgtct attttatttg tcctttcctt tctctatcca gtcattcagc tgaactttat
    31141 ctttgaatgg ttggagggca ttattcgctt ggtgtcacag gtgacaagta gacctctggt
    31201 ctttggacaa cccaatgcat ggtttttaat cctattgtta atttccttgg ctttggtcta
    31261 tgatttgaga aaaaacatta aaaagctaac ggtattgtgc ttattgatta cagggctctt
    31321 tctcctgacc aagcatccac tggaaaatga aatcaccatg ctggatgtgg ggcaaggaga
    31381 aagtattttc ctacgggatg taactgggaa aaccattctc atagatgtag gtggtaaggc
    31441 agaatcttat aagaaaaccg aaaaatggca agaaaagatg acgaccagca atgcacagag
    31501 aagcttgata ccctatctta aaagtcgagg agtagctaag attgaccagc tgattttgac
    31561 aaatacggac aaggaacatg tcggagattt gttagaggtg accaaggctt tccatgtagg
    31621 ggagattcta gtatcaaaag gcagtttgaa gcagaagcaa tttatggtag aactacaggc
    31681 gactcaaaca aaggtgcgta gtatgatagt aggggagaac ttgcccattt ttggaagtca
    31741 gttagaagtt ctatctccaa ggaaaatggg agatggagga cacgatgata ccctagttct
    31801 gtatgggaaa ttcttggata agcaatttct cttcacggga aatttggagg agaaaggaga
    31861 gaaggacttg ctgaagcact atccagactt gaaagtaaat gttttgaaag ctagccaaca
    31921 tggcaataaa aaatcatcaa gtccagcctt tctagaaaaa ctcaaaccag agcttactct
    31981 tatctcagtt ggaaagagca atcgaatgaa actcccccat caggaaacat tgacacgact
    32041 ggaaggtatc aatagcaaag tttatcgaac tgaccagcaa ggagctatac gttttaaggg
    32101 gttggatagt tggaaaatcg aaagtgttcg ataggaaaga taaatgttgt agattagtga
    32161 aataaactaa aaatttgttg cataataatg ataaaaatgg tataatgaaa acgtattcaa
    32221 tattgaggat ataaaatcat taaaaatcag caaaagttat tttattagtt agtttataat
    32281 ctattggtct tcttcagtcc agtgtatctg ctaagagtgt tcttaaaagt atcggtatga
    32341 ttggaatatc ttctataagt ctagtatgaa tttccatgga tatagacata ctaacgttcc
    32401 gtcatggtct cgttattaca gctattctga gtatccagtt ggttctggct ggaactacgg
    32461 tcgttatgag atcataaact attacagcgg aggctattaa ttcttaaaga gtgagaaaaa
    32521 ggagggctag atatgttgca gcttactcat gtgaccttaa aaacgcgaca agtcatcttg
    32581 caagatgcgg atttcacctt taaaaagggt aggttttatg gtcttcttgc tatcaatggc
    32641 tctggaaaga cgaccctgtt ccgtgccatt agcaatttaa ttcccataag tagtggaaat
    32701 atcgcagccc ctccttcttt attttattat gagagtattg aatggctgga tggaaactta
    32761 agtgggatgg actaccttcg tcttatcaaa aacatctgga agtcagacct aaacttgaga
    32821 gatgaaatcg cctactggga aatggctgac tatatcagtc ttcccatccg caagtattcc
    32881 ttaggcatga agcaacgctt ggtgattgct atgtattttc tcagtcaggc aaaatgctgg
    32941 ctcatggatg agattacaaa tggcttagac gagtattatc gacagaagtt ttttgatagg
    33001 ctagcacaaa tcgatagaca agaacagctg gttcttttaa gttcccacta taaggaagag
    33061 ttggttgatg tctgcgatag agtagtaacc attcatcagg ggcagataga agaggtttag
    33121 tttatgaaag atgttagtct atttttattg aaaaaagttt tcaaaagccg cttaaactgg
    33181 attgtcttag ctttatttgt atctgtactc ggtgttacct tttatttaaa tagtcagact
    33241 gcaaactcac acagcttgga gagcaggttg gaaagtcgca ttgcagccaa cgagagggct
    33301 atcaatgaaa atgaagagaa actctcccaa atgtctgata ccagctcgga ggaataccag
    33361 tttgctaaaa ataatttaga cgtgcaaaaa aatcttttga cgcgaaagac agaaattcta
    33421 actttactaa aagaagggcg ctggaaagaa gcctactatc tgcagtggca agatgaagag
    33481 aagaattatg aatttgtatc aaatgacccg actgctagct ctggcttaaa aatgggggtt
    33541 gaccgcgaac ggaagattta ccaagccctg tatcccttga acataaaagc acatactttg
    33601 gattttccga cccacgggat tgatcagatt gtctggattt tagaggttat catcccaagt
    33661 ttgtttgtgg ttgctattat ttttatgcta acacaactat ttgcagaaag atatcaaaat
    33721 catctggaca cagctcactt atatcctgtt tcaaaagtga catttgcaat atcctctctt
    33781 ggagttggag tgggatatgt aactgtgctg tttatcggaa tctgtggctt ttcttttcta
    33841 gtgggaagtc tgataagtgg ttttggacag ttagattatc cctacccaat ttatagctta
    33901 gtgaatcaag aagtaactat tgggaaaata caagatgtat tatttcctgg cttgctctta
    33961 gctttcttag cctttatcgt cattgtggaa gttgtgtact tgattgctta ctttttcaag
    34021 caaaaaatgc ctatcctctt tctttcactc attgggattg ttggcttatt gtttggtatc
    34081 caaaccattc agcctcttca aaagattgca catctgattc cctttactta cttgcgttca
    34141 gtggagattt tatctggaag attacctaag caaattgata atgtcaatct aaattggagc
    34201 atggggatgg tcttgcttcc ttgcctgatt atctttttgc tattgggaat tctatttatt
    34261 gaaagatggg gaagttcaca gaaaaaagaa ttttttaata gattctagct ttcctatagg
    34321 tagggaaaat aagtaaaaac taacatagag agggaatcaa cttgattctc tctttttgat
    34381 tcgaaaacca aaccaaaata caaacacaaa cttttcaaaa aataactttt tatcttgaca
    34441 agagctagaa aacttggtat catataaaag ttgagaaaag cagaagtgag agcttctcgc
    34501 cttgtgacat taagttgcct ggccctacgg atgaaaagtt tcgaagaaac gctatcataa
    34561 cgtgcgggct tgtatattta cgagtccgct attgtttttc tctaataaaa caaaagaggt
    34621 gaaaaccata gcaaagcaag acttattcat caatgatgag attcgtgtac gtgaagttcg
    34681 cttgattggt cttgagggag aacagctagg catcaagcca ctcagtgaag cgcaagcttt
    34741 ggctgataac gctaatgttg acctagtatt gattcaaccc caagccaaac cgcctgttgc
    34801 aaaaattatg gactacggta agttcaaatt tgagtaccag aagaagcaaa aagaacaacg
    34861 taaaaaacaa agcgttgtta ctgtgaaaga agttcgtcta agtccaacaa ttgacaaggg
    34921 tgactttgat acaaaacttc gcaatgcacg taagttcctt gaaaaaggaa ataaagttaa
    34981 ggtatctatt cgctttaagg gtcgtatgat tacccataaa gagattggtg caaaagtttt
    35041 agccgagttt gctgaagcaa ctcaagatat tgccatcatc gaacaacgtg ctaaaatgga
    35101 tggacgtcaa atgttcatgc aattggcgcc agcgactgac aaaaaataat tgtcagaaag
    35161 ttaaataaag gagaaaaaat catgccaaaa caaaaaacac accgcgcatc agctaaacgt
    35221 ttcaaacgta caggttctgg tggacttaaa cgtttccgtg cttacacttc tcaccgtttc
    35281 cacggaaaaa ctaagaaaca acgtcgtcat cttcgtaaag catctatggt gcattcagga
    35341 gattacaaac gtatcaaagc aatgcttact cgcttgaaat aatagcttga ctgtaagtaa
    35401 acaattctag gaaatatttg gaggaaataa aacatggcac gtgttaaagg tggcgttgta
    35461 tcacgcaaac gtcgtaaacg tattcttaaa ttagcaaaag gttactatgg agctaaacac
    35521 atcttgttcc gtactgcaaa agaacaagta atgaactctt actactatgc ataccgtgac
    35581 cgtcgtcaga aaaaacgtga cttccgcaaa ttgtggatta ctcgtatcaa tgcggcagct
    35641 cgtatgaacg gactttcata ctcacaattg atgcatggtt tgaaattggc tgagattgaa
    35701 gttaaccgta aaatgcttgc tgacttggct gttaacgatg cagtagcttt cacagctctt
    35761 gcagatgcag ctaaagcaaa acttggtaaa taacaactga tgagactgga acaggattgt
    35821 ccagtctttt taaaaataaa ggagaaagat atggcttcaa aaatgctaca cacttgctta
    35881 cgagtagaaa atcttgaaaa atcaatcgca ttttatcaag atgcttttgg ttttaaagaa
    35941 ttgcgtcgca gagattttcc agaccatgcc ttcacgattg tctatctagg tcttgagggt
    36001 gatgattatg agttggagtt gacttataac tacgatcacg gtccgtatgt ggttggtgat
    36061 gggtttgccc atatcgccct cagtacacct gatcttgagg cacttcatca agaacacagt
    36121 gcaaaaggct atgaagtgac tgagccaaat ggtctaccag gaactacacc aaactattac
    36181 tttgttaaag accctgatgg atataaggtc gaagtcattc gtgaaaaata atttcgtgca
    36241 agttaagtag aatattcgtt ttctacttga ctttttttag ctgaaagagt atactaataa
    36301 aaattcaacc tttaagggga gtccagagag actcacaagg tgtcagataa aagaatagtg
    36361 caattttcta gaggagacct tttgagtgtg ctctcttgtg ttgtacgatt ttaactgagg
    36421 ccttgcacta gcaaggtctt ttctttatct ggtcccctta aaatttaagg aggaaaagtt
    36481 atgaatctca catgtaagaa gcgtttgggt gtcattcggt tggaaaccat gaaggtggtt
    36541 gcacaagagg aaatcgcgcc agcaatcttt gaattagtcc tagaaggaga aatggttgaa
    36601 gccatgcgag caggccaatt tcttcatctg cgtgtaccag acgatgccca tctcttacgt
    36661 cgtcctattt caatttcgtc tattgacaag gcaaacaagc agtgtcacct catttatcgg
    36721 attgagggag ctgggactgc aattttttca accttaagtc agggagacac tcttgatgtg
    36781 atggggcctc agggaaatgg ttttgacttg tctgaccttg atgagcagaa tcaggttctc
    36841 cttgttggtg gtgggattgg tgttccaccc ttgcttgagg tggccaagga attgcatgaa
    36901 cgtggagtga aagtagtgac agtcctcggt tttgctaata aggatgctgt tattttgaaa
    36961 acggaattgg ctcagtatgg tcaggtcttt gtaacgacag atgatggttc ttatggcatc
    37021 aagggaaatg tttccgttgt tatcaatgat ttagatagtc agtttgatgc tgtttactcg
    37081 tgtggggctc caggaatgat gaagtatatc aatcaaacct ttgatgatca cccaagagcc
    37141 tatttatctc tggaatctcg tatggcttgt gggatgggag cttgctatgc ctgtgttcta
    37201 aaagtaccag aaaacgagac ggtcagccaa cgcgtctgtg aagatggtcc tgttttccgc
    37261 acaggaacag ttgtattata aggagaaaat tatgactaca aatcgattac aagtttctct
    37321 acctggtttg gatttgaaaa atccgattat tccagcatca ggctgttttg gctttggaca
    37381 agagtatgcc aagtactatg atttagacct tttaggttct attatgatca aggcgacaac
    37441 ccttgaacca cgttttggga atccaactcc aagagtggca gagacgcctg ctggtatgct
    37501 caatgcaatt ggcttgcaaa atcctggttt agaggttgtt ttggctgaaa agctaccttg
    37561 gctggaaaga gaatatccaa atcttcctat tattgccaat gtagctggtt tttcaaaaca
    37621 agagtatgca gctgtttctc atgggatttc caaggcaact aatgtaaaag ctatcgagct
    37681 caatatttct tgtcccaatg ttgaccactg taatcatgga cttttgattg gtcaagatcc
    37741 agatttggct tatgatgtgg tgaaagcagc tgtggaagcc tcagaagtgc cagtttatgt
    37801 caaattaacc ccgagtgtga ccgatatcgt tactgtcgca aaagctgcag aagatgcggg
    37861 agcaagtggc ttgaccatga tcaatactct ggttggaatg cgctttgacc tcaaaaccag
    37921 aaaaccaatc ttggccaatg gaacaggtgg aatgtcaggt ccagcagtct ttccagtagc
    37981 cctcaaactc atccgccaag tagcccaaac aacagacctg cctatcattg gaatgggggg
    38041 agtggattcg actgaagctg ccctagaaat gtatctagct ggggcatctg ctatcggagt
    38101 tggaacagct aactttacca atccttatgc ctgccctgac atcatcgaaa atttaccaaa
    38161 agtcatggat aaatacggta ttagcagtct ggaagaactc cgtcaggaag taaaagagtc
    38221 tctgaggtaa actgcaatca atctgttctt gattttttat tagtttgtaa tatgaattta
    38281 ggagaatttt ggtacaataa aataaataag aacagaggaa gaaggttaat gaagaaagta
    38341 agatttattt ttttagctct gctatttttc ttagctagtc cagagggtgc aatggctagt
    38401 gatggtactt ggcaaggaaa acagtatctg aaagaagatg gcagtcaagc agcgaatgag
    38461 tgggtttttg atactcatta tcaatcttgg ttctatataa aagcagatgc taactatgct
    38521 gaaaatgaat ggctaaagca aggtgacgac tatttttacc tcaaatctgg tggctatatg
    38581 gccaaatcag aatgggtaga agacaaggga gccttttatt atcttgacca agatggaaag
    38641 atgaaaagaa atgcttgggt aggaacttcc tatgttggtg caacaggtgc caaagtaata
    38701 gaagactggg tctatgattc tcaatacgat gcttggtttt atatcaaagc agatggacag
    38761 cacgcagaga aagaatggct ccaaattaaa gggaaggact attatttcaa atccggtggt
    38821 tatctactga caagtcagtg gattaatcaa gcttatgtga atgctagtgg tgccaaagta
    38881 cagcaaggtt ggctttttga caaacaatac caatcttggt tttacatcaa agaaaatgga
    38941 aactatgctg ataaagaatg gattttcgag aatggtcact attattatct aaaatccggt
    39001 ggctacatgg cagccaatga atggatttgg gataaggaat cttggtttta cctcaagttt
    39061 gatggcaaaa tggctgaaaa agaatgggtt tacgattctc atagtcaagc ctggtactac
    39121 ttcaaatccg gtggttacat gacagccaat gaatggattt gggataagga atcttggttt
    39181 tacctcaaat ctgatgggaa aatagctgaa aaagaatggg tctacaattc tcatagtcaa
    39241 gcttggtact acttcaaatc cggtggttac atgacagcca atgaatggat ttgggataag
    39301 gaatcttggt tttacctcaa gtctgatggc aaaatggctg aaaaagaatg ggtctacgat
    39361 tctcatagtc aagcctggta ctacttcaaa tctggtggct acatggcgaa aaatgagaca
    39421 gtagatggtt atcagcttgg aagcgatggt aaatggcttg gaggaaaagc tacaaatgaa
    39481 aatgctgctt actatcaagt agtgcctgtt acagccaatg tttatgattc agatggtgaa
    39541 aagctttcct atatatcgca aggtagtgtc gtatggctag ataaggatag aaaaagtgat
    39601 gacaagcgct tggctattac tatttctggt ttgtcaggct atatgaaaac agaagattta
    39661 caagcgctag atgctagtaa ggactttatc ccttattatg agagtgatgg ccaccgtttt
    39721 tatcactatg tggctcagaa tgctagtatc ccagtagctt ttcatctttc tgatatggaa
    39781 gtaggcaaga aatattattc ggcagatggc ctgcattttg atggttttaa gcttgagaat
    39841 cccttccttt tcaaagattt aacagaggct acaaactaca gtgctgaaga attggataag
    39901 gtatttagtt tgctaaacat taacaatagc cttttggaga acaagggcgc tacttttaag
    39961 gaagccgaag aacattacca tatcaatgct ctttatctcc ttgcccatag tgccctagaa
    40021 agtaactggg gaagaagtaa aattgccaaa gataagaata atttctttgg cattacagcc
    40081 tatgatacga ccccttacct ttctgctaag acatttgatg atgtggataa gggaatttta
    40141 ggtgcaacca agtggattaa ggaaaattat atcgataggg gaagaacttt tcttggaaac
    40201 aaggcttctg gtatgaatgt ggaatatgct tcagaccctt attggggcga aaaaattgct
    40261 agtgtgatga tgaaaatcaa tgagaagcta ggtggcaagg attagtacta taagtgaata
    40321 tgatttgagt gaatagtaag ttaaaaatcc tgatttcaag taaaatcagg attttttcat
    40381 ggatgcaatt tttttggagt ctggtgtgac gcggagggtc ttttgtcctg tgtaagtgac
    40441 aaagccgggt tttccaccag ttggtttatt gagttttttg acttcaatca tatctacctg
    40501 caccagattc gacaggcgcc cttgagagaa gtaggcagct aactctgctg cgtctgtctt
    40561 gactgcatca gatgggtcaa gatttcctga gatgataaca tggcttccag gaatgtcctt
    40621 agcatggaac caaagttcct ccttgcgggc cattttaaag gtcaattcct cattttgaag
    40681 attgtttcgt ccgacataga tgatggtttt gccatcgctt gctagatatt gttctagttt
    40741 tttgcgtttc tggattttct cccgttgtct tctgcggata aaacctgttt gaatcaattc
    40801 ttcacggatt tcagcgattt cttccagtcc agcttggttg aggacggttt ctacactttc
    40861 cagatagaga atagtggctt tggtttcttc aatcaaatca gtcaagtatt tgacagcttc
    40921 tttgagtttc tgataccgtt taaaatagcg ttgggcattc tggttgggag tcagagcctt
    40981 atcaagcgca atcatgatag gttggttggt atagtagttg tctaggataa cctggtcttg
    41041 gtcgttaggc acttggtgta ggaaggttgt cagcaattct cctttttgac gaaattcttc
    41101 agcgttgtct gtcgccagta actctttttc ctgttttttg agtttgtgtc ggtttttctg
    41161 aagttcattt tcaacacgac gaatcagttc actggcctgc tgtttgacgc ggtcgcgctc
    41221 agccttatcc ttatagtagg tgtccaacaa atcagaaaga tttgcaaaag gctctcccac
    41281 ctgatttgca aaaggaactg gactgaagga agtctcagtc aagcatggct tggtttcttg
    41341 attgaaaaaa tttcggaaag cggaaagttt ttcactaacc agtatccttt ccaattcatt
    41401 tgccgtatcg cgtcccagac cttgaaagag gctttgaaga ttttttgctg ttagttcttg
    41461 ggtttgcagg atttcaaaga gcttttcatc cttgatagta aaaggattga gagattctgt
    41521 acttggcgga gcgatatagg tcgatcctgg aagtaaggtg cggtagctat tttgtgaaaa
    41581 accgacgtgt ttgataactt cgaggatttt atgactgctt ttatcgacca gtagaatatt
    41641 actgtgtttc cccataattt caataatcaa ggtagcctgg atatggtctc caatctcgtt
    41701 tttattggaa actgtcattt ccacaatacg gtcattttcc acttgctcaa tcgactcaat
    41761 cagggccccc tgcaaatact ttctcaaaac catgataaag gtagaaggtt gagctggatt
    41821 ttcaaaagtc gtttgggtca gctgaatgcg tccaaaaact ggatgggcag aaaggagcag
    41881 gcgatggctt tggcgattgc tgcggatttg caagaccaac tcttgttcaa aaggctgatt
    41941 gattttctgg atgcgaccat tcactaattc gtttcgcaat tcctcaacta tgtggtgtaa
    42001 aaaaaatcca tcaaatgaca tcgttctctc cttgtgattg tattccatag tattatatca
    42061 aaaaggtaga ataaaatcat ggaaatgtgg tataataaag ccaagtaaag agaaatgaga
    42121 agcacatgta tattgaaatg gtagatgaaa ctggtcaagt ttcaaaagaa atgttgcaac
    42181 aaacccaaga aattttggaa tttgcagccc aaaaattagg aaaagaagac aaggagatgg
    42241 cagtcacttt tgtgaccaat gagcgtagtc atgaacttaa tctggagtac cgtgacaccg
    42301 accgtccgac agatgtcatc agccttgagt ataaaccaga attggaaatt gcctttgacg
    42361 aagaggattt gcttgaaaat ccagaattgg cagagatgat gtctgagttt gatgcctata
    42421 ttggggaatt gttcatctct atcgataagg ctcatgagca ggccgaagaa tatggtcaca
    42481 gctttgagcg tgagatgggc ttcttggcag tacacggctt tttacatatt aacggctatg
    42541 atcactacac tccggaagaa gaagcggaga tgttcggttt acaagaagaa attttgacag
    42601 cctatggact cacaagacaa taaacgaaaa tggaaaaatc gtgacctgat atccagttta
    42661 gaatttgcca tcacagggat ttttactgct atcaaggaag aacgaaatat gcgaaaacat
    42721 gcagtgacgg ctctagtggt catccttgca ggttttgttt ttcaggtgtc acgaatcgaa
    42781 tggctctttc tcctattgag cattttcttg gtagtagcct ttgagattat caactctgct
    42841 attgaaaata tggtggattt ggccagtcac tatcactttt ccatgctggc taaaaatgcc
    42901 aaggatatgg cggctggcgc ggtattagtg gtttctcttt tcgcagcctt aacaggtgca
    42961 ttgatttttc tcccacgaat ctgggattta ttattttaaa cagtaagagg aaattatgac
    43021 ttttaaatca ggctttgtag ccattttagg acgtcccaat gttgggaagt caaccttttt
    43081 aaatcacgtt atggggcaaa agattgccat catgagtgac aaggcgcaga caacgcgcaa
    43141 taaaatcatg ggaatttaca cgactgataa ggagcaaatt gtctttatcg acacaccagg
    43201 gattcacaaa cctaaaacag ctctcggaga tttcatggtt gagtctgcct acagtaccct
    43261 tcgcgaagtg gacactgttc ttttcatggt gcctgctgat gaagcgcgtg gtaaggggga
    43321 cgatatgatt attgagcgtc tcaaggctgc caaggttcct gtgattttgg tggtgaataa
    43381 aatcgataag gttcatccag accagctctt gtctcagatt gatgacttcc gtaatcaaat
    43441 ggactttaag gaaattgttc caatctcagc ccttcaggga aataacgtgt ctcgtctagt
    43501 ggatattttg agtgaaaatc tggatgaagg tttccaatat ttcccgtctg atcaaatcac
    43561 agaccatcca gaacgtttct tggtttcaga aatggttcgc gagaaagtct tgcatctaac
    43621 tcgtgaagag attccgcatt ctgtagcagt agttgttgac tctatgaaac gagacgaaga
    43681 gacagacaag gttcacatcc gtgcaaccat catggtcgag cgcgatagcc aaaaagggat
    43741 tatcatcggt aaaggtggcg ctatgcttaa gaaaatcggt agcatggccc gtcgtgatat
    43801 cgaactcatg ctaggagaca aggtcttcct agaaacctgg gtcaaggtca agaaaaactg
    43861 gcgcgataaa aagctagatt tggctgactt tggctataat gaaagagaat actaagtaga
    43921 ggtaggctca tgcctgcttc ttgtttttac agaaggagga cttatgcctg aattacctga
    43981 ggttgaaacc gtttgtcgtg gcttagaaaa attgattata ggaaagaaga tttcgagtat
    44041 agaaattcgc taccccaaga tgattaagac ggatttggaa gagtttcaaa gggaattgcc
    44101 tagtcagatt atcgagtcaa tgggacgtcg tggaaaatat ttgctttttt atctgacaga
    44161 caaggtcttg atttcccatt tgcggatgga gggcaagtat ttttactatc cagaccaagg
    44221 acctgaacgc aagcatgccc atgttttctt tcattttgaa gatggtggca cgcttgttta
    44281 tgaggatgtt cgcaagtttg gaaccatgga actcttggtg cctgaccttt tagacgccta
    44341 ctttatttct aaaaaattag gtcctgaacc aagcgaacaa gactttgatt tacaggtctt
    44401 tcaatctgcc cttgccaagt ccaaaaagcc tatcaaatcc catctcctag accagacctt
    44461 ggtagctgga cttggcaata tctatgtgga tgaggttctc tggcgagctc aggttcatcc
    44521 agctagacct tcccagactt tgacagcaga agaagcgact gccattcatg accagaccat
    44581 tgctgttttg ggccaggctg ttgaaaaagg tggctccacc attcggactt ataccaatgc
    44641 ctttggggaa gatggaagca tgcaggactt tcatcaggtc tatgataaga ctggtcaaga
    44701 atgtgtacgc tgtggtacca tcattgagaa aattcaacta ggcggacgag gcacccactt
    44761 ttgtccaaac tgtcaaagga gggactgatg agaaaaatca tcggaatcac tgggggaatt
    44821 gcctctggta agtcaactgt gacaaatttt ctaagacagc aaggctttca agtagtggat
    44881 gccgacgcag tcgtccacca actacagaaa tctggtggtc gtctgtttga ggctctagta
    44941 cagcactttg ggcaagaaat cattcttgaa aacggagaac tcaatcgccc tctcctagct
    45001 agtctcatct tttcaaatcc tgaagagcaa aaatggtcta agcaaattca aggggagatt
    45061 atccgtgagg aactggctac tttgagagaa cagttggctc agacagaaga gattttcttc
    45121 atggatattc ccctactttt tgagcaggac tacagcgatt ggtttgctga gacttggttg
    45181 gtctatgtgg accgagatac ccaagtagaa cgcttaatga aaagggacca gttgtccaaa
    45241 gatgaagctg agtctcgtct ggcagcccag tggcctttag aaaaaaagaa agatttggcc
    45301 agccaggttc ttgataataa tggcaatcag aaccagcttc ttaatcaagt gcatatcctt
    45361 cttgagggag gtaggcaaga tgacagagat taactggaag gataatctgc gcattgcctg
    45421 gtttggtaat tttctgacag gagccagtat ttctttggtt gtacctttta tgcccatctt
    45481 cgtggaaaat ctaggtgtag ggagtgagca agtcgctttt tatgcaggct tagcaatttc
    45541 tgtctctgct atttccgcgg cgctcttttc tcctatttgg ggtattcttg ctgacaaata
    45601 cggccgaaaa cccatgatga ttcgggcagg tcttgctatg actatcacta tgggaggctt
    45661 ggcctttgtc ccaaatatct attggttaat ctttcttcgt ttactaaacg gtgtatttgc
    45721 aggttttgtt cctaatgcaa cggcactgat agccagtcag gttccaaagg agaaatcagg
    45781 ctctgcctta ggtactttgt ctacaggcgt agttgcaggt actctaactg gtccctttat
    45841 tggtggcttt attgcagaat tatttggcat tcgtacagtt ttcttactgg ttggtagttt
    45901 tctattttta gctgctattt tgactatttg ctttatcaag gaagtttttc aaccagtagc
    45961 caaggaaaag gccattccaa caaaggaatt atttacctcg gttaaatatc cctatctttt
    46021 gctcaatctc tttttaacca gttttgtcat ccaattttca gctcaatcga tcggccctat
    46081 tttggctctt tatgtacgcg acttagggca gacagagaat cttctttttg tctctggttt
    46141 gattgtgtcc agtatgggct tttccagtat gatgagtgca ggagttatgg gaaagctagg
    46201 tgacaaggtg ggcaatcatc gtctcttggt tgtcgcccaa ttttattcag tcatcatcta
    46261 tctcctctgt gccaatgcct ctagccccct tcaactagga ctctatcgat tcctctttgg
    46321 cttgggaacc ggtgccttga ttcccggggt taatgcccta ctcagcaaaa tgactcccaa
    46381 agccggcatt tcgagggtct ttgccttcaa tcaggtattc ttttatctgg gaggtgttgt
    46441 tggtcccatg gcaggttctg cagtagcagg tcaatttggc taccatgctg tcttttatgc
    46501 gacaagcctt tgtgttgcct ttagttgtct ctttaacctg attcaatttc gaacattatt
    46561 aaaagtaaag gaaatctagt gcgagtaaaa attaatctca aatgctcctc ttgtgacagt
    46621 atcaattacc taaccagtaa aaattcaaaa acccatccag acaagattga ggttttaaag
    46681 tattgtccca aggaaagaaa agtaacccta catcttgaat ctaagtagat tttatggtaa
    46741 aataataggg attttaagga gtttgatatg tataacctat tattaaccat tttattagta
    46801 ttatctgttg tgattgtgat tgcaattttc atgcaaccaa ccaaaaacca atccagcaat
    46861 gtatttgatg ccagttcagg tgatttgttt gaacgcagta aagctcgcgg ttttgaagct
    46921 gtaatgcagc gtttgacagg gattttagtc tttttctggc tagccattgc cttagcattg
    46981 acggtattat caagtagata agaaaataat gggcaggact aggtctttgc ctctttttat
    47041 ttttaaagga tgtttgagaa ggttttacag taaaagaaaa ttaaaaaatc tagaaagaaa
    47101 atatgaaaga tagaataaaa gaatatttac aagacaaggg aaaggtgact gttaatgatt
    47161 tggctcaggc tttgggaaaa gacagttcca aggattttcg tgagttgatt aaaaccttgt
    47221 ccttaatgga aagaaagcac caaattcgtt ttgaagaaga tggcagtctg accttggaag
    47281 ccaagaaaaa acatgagatt accctcaagg ggatttttca tgcccataaa aatggttttg
    47341 gttttgtcag cctagaaggg gaagaggacg acctttttgt agggaaaaat gatgtcaact
    47401 atgctattga tggtgatacc gtcgaggtag tgattaagaa agtcgctgac cgcaataagg
    47461 gaacagcagc agaagccaaa attattgata tcctagaaca cagtttgaca acagttgtcg
    47521 ggcaaatcgt tctggatcag gaaaagccta agtatgctgg ctatattcgt tcaaaaaatc
    47581 agaaaatcag tcaaccgatt tatgttaaga aaccagccct aaagttagaa ggaacagaag
    47641 ttctcaaggt ctttatcgat aaatacccaa gcaagaaaca tgatttcttt gtcgcgagtg
    47701 ttctcgatgt ggtgggacac tcaacggatg tcggaattga tgttcttgag gtcttggaat
    47761 caatggacat tgtatccgag tttccagaag ctgttgtcaa ggaagcagaa agtgtgcctg
    47821 atgctccgtc tcaaaaggat atggaaggtc gtctggatct aagagatgaa attaccttta
    47881 ccattgacgg tgcggatgcc aaggacttgg acgatgcagt gcatatcaag gctctgaaaa
    47941 atggcaatct ggagcttggg gttcacatcg cagatgtttc ctattatgtg accgagggtt
    48001 ctgcccttga caaggaagcc cttaaccgtg cgacttctgt ttacgtgaca gaccgagtgg
    48061 tgccaatgct tccagaacga ctatcaaatg gcatctgctc tctcaatccc caagttgacc
    48121 gcctgaccca gtctgctatt atggagattg ataaacatgg tcgtgtggtc aactatacca
    48181 ttacacaaac agttatcaag accagttttc gtatgaccta tagcgatgtc aatgatatcc
    48241 tagctggcga tgaagaaaag agaaaagaat accataaaat tgtaccaagt atcgaactca
    48301 tggccaagct tcatgaaact ttagaaaaca tgcgtgtgaa acgtggagct ctcaattttg
    48361 ataccaatga agcgaagatt ttagtggata aacaaggtaa gcctgttgat atcgttcttc
    48421 ggcagcgtgg cattgccgag cggatgattg agtcttttat gttgatggct aatgaaacag
    48481 ttgccgaaca tttcagcaag ttggatttgc cttttatcta ccgaattcac gaggagccta
    48541 aggctgaaaa ggttcagaag tttattgatt atgcttcgag ttttggcttg cgcatttatg
    48601 ggactgccag tgagattagc caggaggcac ttcaagacat catgcgtgct gttgagggag
    48661 aaccttatgc agatgtattg tccatgatgc ttcttcgctc tatgcagcag gctcgttatt
    48721 cggagcacaa tcacggccac tatggactag ctgctgacta ttatactcac tttaccagtc
    48781 caattcgtcg ttatccagac cttcttgttc accgtatgat tcgggattac ggccgttcta
    48841 aggaaatagc agagcatttt gaacaagtga ttccagagat tgcgacccag tcttccaacc
    48901 gtgaacgtcg tgccatagaa gctgagcgtg aagtcgaagc catgaaaaag gctgagtata
    48961 tggaagaata cgtgggtgaa gagtatgatg cagttgtatc aagtattgtc aaattcggtc
    49021 tctttgtcga attgccaaac acagttgaag gcttgattca catcactaat ctacctgaat
    49081 tttatcattt caatgagcgt gatttgactc ttcgtggaga aaaatcaggt atcactttcc
    49141 gagtgggtca gcagatccgt atccgtgttg aaagagcgga taaaatgact ggagagattg
    49201 atttttcatt cgtacctagt gagtttgatg tgattgaaaa aggcttgaaa cagtctagtc
    49261 gtagtggcag agggcgtggt tcaaatcgtc gttcggataa gaaggaagac aagagaaaat
    49321 caggacgctc aaatgataag cgtaaacatt cacaaaaaga caagaagaaa aaaggaaaga
    49381 aaccttttta caaggaagta gctaagaaag gagccaagca tggcaaaggg cgagggaaag
    49441 gtcgtcgcac aaaataaaaa ggcacgccac gactatacaa tcgtagatac gctagaggca
    49501 gggatggtcc tgactggaac tgaaatcaag agtgtacgag ctgctcgaat taatctcaag
    49561 gatggctttg ctcaagtgaa aaatggagaa gtttggctga gcaatgttca tatcgcacct
    49621 tacgaagagg gcaatatctg gaaccaggaa ccagaacgtc gtcgtaaact cctgctccat
    49681 aaaaagcaaa ttcaaaaatt ggaacaagag accaaaggga caggaatgac cttagttccc
    49741 cttaaggtct atataaaaga tggctacgct aagcttcttt taggacttgc caaagggaag
    49801 catgactatg acaaacggga gtctatcaaa cgtcgtgagc aaaatcgaga tatcgcgcgt
    49861 gtgatgaaag ctgttaatca gcgataaaaa gaggaattga aaatggaaaa attagttgcc
    49921 tataaacgca tgcctttgtg gaataaacaa acaatgcctg aagctgttca gcaaaagcac
    49981 aatacaaaag ttgggacttg ggggaaaatt actgtcttga agggagctct caagtttatt
    50041 gaattgacag aagaagggga agttctagct gaacacctct ttgaagcagg ggcagacaat
    50101 ccaatggccc agcctcaagc ctggcaccga gtggaagctg ccacagatga tgtggaatgg
    50161 tacttggaat tttattgtaa acctgaggat tattttgcta aaaaatacaa taccaaacct
    50221 gttcattcag aggtcctaga ggccatgcag acagtgaaac aagggaaagc tttggatttg
    50281 ggttgtggtc aggggcgtaa ttctcttttt ctagcccagc aagattttga tgtgacggct
    50341 gtagatcaaa atggactggc tcttgaaatc ttgcaaagca ttgtggagca ggaagatttg
    50401 gacatacctg ttgaccttta cgatatcaat tcagctagca ttggacaaga atatgatttt
    50461 atcgtttcaa cagttgttct catgtttcta caagcggacc gcattccagc tattattcaa
    50521 aatatgcagg agaaaaccag tgttggtggt tacaacctta tcgtttgtgc catggacacg
    50581 gaggactatc cttgctcggt taacttccca ttcaccttta aagaaggaga actggcagac
    50641 tattacaagg attgggaatt ggttaagtac aatgaaaatc caggccattt gcatcgtcgc
    50701 gatgagaatg gcaatcgtat tcaactacgc tttgcgacct tactagctaa gaaaatcaag
    50761 taaacacaca tgaagattag gaattttcct gatctttttt cttttttacg aatgatatag
    50821 aaaaggaggg aattcatgtt tgttgcgaga gatgctaggg gagaattggt aaatgtgtta
    50881 gaggataaac ttgagaagca agcatacacc tgcccagctt gtggaggcca gctccatttg
    50941 cgtcaaggac caagtgtacg gacgcatttt gcccataaat ccttaaaaga ctgtgatttt
    51001 ttctttgaaa atgaaagtcc agaacacctg gccaataagg aatccctcta tcactggtta
    51061 aaaaaagaga caaaggttca attagagtac ccgctttcag aacttaaaca gattgcggat
    51121 gtatttgtaa atggcaatct agctctagaa gttcagtgta gtcccttgcc tcagaaagtc
    51181 cttaaagagc gaagtgaggg atatcgtagt cagggttacc aagtactgtg gttgctgggt
    51241 caaaaactgt ggctcaagga gcgtttgact cgtctacagc aaggttttct ttatttcagt
    51301 caaaacatgg gcttttatgt ttgggaatta gacaaggaaa aacaagtttt aagactcaaa
    51361 tacctgattt accaggatct ccgcggtaaa ctccattatc aaatcaagga attttcctat
    51421 ggtcaaggta gtttattgga aatattgcgt cttccctata agagacaaaa aatatctcat
    51481 tttacagttt ctgaggacaa ggacatctgt cgctatatcc ggcaacaact ttattatcaa
    51541 aatctctttt ggatgaaaga acaagcagaa gcctatcaaa agggagaaaa tatcctgact
    51601 tatggactga aagaatggta tccacaaatt cgaccaatag tgggcaaatt tttccagatt
    51661 gaacaagact tgactagcta ttatcagcac ttttatacct attaccaaaa aaatcctcaa
    51721 aatgattggc aaaagcttta tccaccagcc ttttatcagc aatatttctt gaaaaatatg
    51781 gtagaataga aaggatggag gaatctaatg gtattacaaa gaaatgaaag aaatgaaata
    51841 aatgaaaaag atacatggga tctatcaacg atctacccaa ctgaccaggc ttgggaagaa
    51901 gccttaaaag atttaacaga acaattggag acagtagccc agtatgaagg ccatctcttg
    51961 gatagtgcgg ataacctact agaaatcact gaattttctc ttgaaatgga acgccagatg
    52021 gagaagcttt acgtttatgc tcatatgaag aatgaccagg atacacgtga agctaagtat
    52081 caagagtact atgccaaggc catgacactc tacagccagt tagaccaagc cttttcattc
    52141 tatgatcctg aatttatgga gattagcgaa aagcagtatg ctgacttttt agaagctcaa
    52201 ccaaagctgc aggtttatca acactatttt gacaagctct tgcaaggcaa ggatcacgtt
    52261 ctttcacaac gtgaagaaga attattggct ggagctggag aaatctttgg ttcagcaagt
    52321 gaaaccttcg ctatcttgga caatgcggat attgtgttcc cttatgtcct agacgatgat
    52381 ggtaaagaag ttcagctatc tcatgggact tacacacgtt tgatggagtc taaaaaacgt
    52441 gaggttcgcc gtggtgccta tcaagctctt tatgcgactt acgaacaatt ccaacacacc
    52501 tatgccaaaa ccttgcaaac caatgttaag gtgcaaaatt accgtgctaa agttcgtaac
    52561 tacaagagtg ctcgtcatgc agccctcgca gcgaattttg ttccagaaag tgtttatgac
    52621 aatttggtag cagcagttcg caagcatttg ccactcttac atcgctatct tgagcttcgt
    52681 tcaaaaatct tggggatttc agatctcaag atgtacgatg tctacacacc gctttcatct
    52741 gttgaataca attttaccta ccaagaagcc ttgaaaaaag cagaagatgc tttggcagtc
    52801 ttgggtgagg attacttgag ccgtgtcaaa cgtgccttca gcgagcgttg gattgatgtt
    52861 tacgaaaatc aaggcaagcg ttcaggtgcc tactctggtg gttcttacga taccaatgcc
    52921 tttatgcttc tcaactggca ggacaatctg gacaatctct ttactcttgt tcatgaaaca
    52981 ggtcacagta tgcattcaag ctatactcgt gaaactcagc cttatgttta cggagattac
    53041 tctatctttt tggctgagat tgcctcaact accaatgaaa atatcttgac ggagaaatta
    53101 ttggaagaag tggaagacga cgcaacacgc tttgctattc tcaataactt cctagatggt
    53161 ttccgtggaa cagttttccg ccaaactcaa tttgctgagt ttgaacacgc cattcaccaa
    53221 gcagatcaaa atggggaggt cttgacaagc gatttcctaa ataaactcta cgcagacttg
    53281 aaccaagagt attatggttt gagtaaggaa gacaatcctg aaatccaata cgagtgggct
    53341 cgcattccac acttctacta taactactat gtatatcaat attcaactgg ctttgcggcc
    53401 gcctcagcct tggctgaaaa aattgtccat ggtagtcaag aagaccgtga ccgctatatc
    53461 gactacctca aggcaggtaa gtcggactat ccacttaatg tcatgagaaa agctggtgtt
    53521 gatatggaga aggaagacta cctcaacgat gcctttgcag tctttgaacg ccgtttaaat
    53581 gagtttgaag cccttgttga aaaattagga ttggcataaa atggttgaat cgtatagtaa
    53641 gaatgctaac cataacatgc gtcgtcctgt cgtcaaagaa gaaattgtag acttgatgcg
    53701 tcagcgtcaa aagcaggtca caggtttctt gaaagaattg gaagactttg cccgcaagga
    53761 aaatattcct attattcccc atgaaacggt tgcttatttc cgttttctta tggaaaccat
    53821 gcagcctaaa aatattctgg aaattgggac ggctatcggt ttttcagctc tcttgatggc
    53881 tgaacatgcg ccaaatgcta agattacaac tattgatcgt aatccagaaa tgattggttt
    53941 tgccaaggaa aattttgccc agtttgacag tcgcaagcaa atcactctcc tagagggaga
    54001 tgcggtggat gtcttatcta cactgacaga gtcttatgat ttcgtcttta tggattctgc
    54061 caagtctaaa tacatcgtct ttctgccaga aatcctcaaa catttggaag ttggtggtgt
    54121 ggttgtcttg gatgatattt ttcaaggtgg tgatgttgcc aaggatatta tggaagtccg
    54181 tcgtggtcag cgaaccattt atcgaggcct tcaaaaatta ttttatgcaa ccttagacaa
    54241 tccagaactc accgcaacat tagtgccttt aggagatggt attctcatgc ttcgtaaaaa
    54301 tgtagcagat gttcaactgt ctgaaagcga atgattttca gaaaaattta agaaaaaata
    54361 gtaaaataga tagagtaaca cttatctcaa aggagtagac atgaagaaaa aattattggc
    54421 aggtgccatc acactattat cagtagcaac tttagcagct tgttcgaaag ggtcagaagg
    54481 ggcagacctt atcagcatga aaggggatgt catcacagaa catcaatttt atgagcaagt
    54541 gaaaaacaac ccttcagccc aacaagtctt gttaaatatg accatccaaa aagtttttga
    54601 aaaacaatat ggctcagagc ttgatgataa agaggttgat gatactattg ccgaagaaaa
    54661 aaaacaatat ggcgaaaact accaacgtgt cttgtcacaa gcaggtatga ctcttgaaac
    54721 acgtaaagct caaattcgta caagtaaatt agttgagttg gcagttaaga aggtagcaga
    54781 agctgaattg acagatgaag cctataagaa agcctttgat gagtacactc cagatgtaac
    54841 ggctcaaatc atccgtctta ataatgaaga taaggccaaa gaagttctcg aaaaagccaa
    54901 ggcagaaggt gctgattttg ctcaattagc caaagataat tcaactgatg aaaaaacaaa
    54961 agaaaatggt ggagaaatta cctttgattc tgcttcaaca gaagtacctg agcaagtcaa
    55021 aaaagccgct ttcgctttag atgtggatgg tgtttctgat gtgattacag caactggtac
    55081 acaagcttac agtagccaat attacattgt aaaactcact aagaaaacag aaaaatcatc
    55141 taatattgat gactacaaag aaaaattaaa aactgttatc ttgactcaaa aacaaaatga
    55201 ttcaacattt gttcaaagca ttatcggaaa agaattgcaa gcagccaata tcaaggttaa
    55261 ggaccaagcc ttccaaaata tctttaccca atatatcggt ggtggagatt caagctcaag
    55321 cagtagtaca tcaaacgaat agtccaaatc aatgagtcag ggaaaaaaac tcgacttcag
    55381 gaaaaaatga agcaaacatt cccacaataa aacgcatagt acaaggtttg tactgccccc
    55441 aaaagttaga caattaattt atctgaagga tttagttctg tattgcacag ggctaagtcc
    55501 ttttagtttt accttaattc tcttattgtt ctaataatca atatagtcta taatggcttg
    55561 ttccaattga ttaagtgatt taaatgtttt ctcatagcca taaaacattt cggattttaa
    55621 aatgccaaag aaagattcca tcctaccgtt gtcttggctg tttcctttgc gtgacataga
    55681 tgcttgaatt cccttactct ctaggaagcg atgataagaa tcgtgttggt attgccagcc
    55741 ttggtcacta tggagaatcg tattctcgta gtgcttctct ttgaatgcct gttccaacat
    55801 taacgatcaa tcaatttaat catgtaccta a
//
LOCUS       DAVHIZ010000005        52195 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.005, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000005 DAVHIZ010000000
VERSION     DAVHIZ010000005.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 52195)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 52195)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..52195
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.005"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            370..1506
                     /gene="lctO"
                     /locus_tag="VVO18_000321"
     CDS             370..1506
                     /gene="lctO"
                     /locus_tag="VVO18_000321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120720.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate oxidase"
                     /protein_id="HEU5585540.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAEDTF
                     TLRENIRAFNHKLIVPHTLCDVENPSTEIEFAGEKLSSPIIMAPVAAHKLANEQGEVA
                     TARGVHEFGSLYTTSSYSTVDLPEISEALQGTPHWFQFYFSKDDGINRHIMDRVKAEG
                     YKAIVLTADATVGGNREVDKRNGFVFPVGMPIVEEYLPEGAGKSMDFVYKSAKQRLSP
                     RDVEFIAEYSGLPVYVKGPQCREDVERSLAAGASGIWVTNHGGRQIDGGPAAFDSLQE
                     VAEAVDRRVPIVFDSGVRRGQHVFKALASGADLVAIGRPVIYGLALGGSVGVRQVFEH
                     LNAELKTVMQLSGAQTIEDVKHFKLRHNPYNPTFPVDPRDLKLY"
     regulatory      1758..1846
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            2062..2730
                     /locus_tag="VVO18_000322"
     CDS             2062..2730
                     /locus_tag="VVO18_000322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000449895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TenA family protein"
                     /protein_id="HEU5585541.1"
                     /translation="METQDYAFQPGLTVGELLKSSQKDWQAAINHRFVKELFAGTIEN
                     KVLKDYLIQDYHFFDAFLSMLGACVAHADKLESKLRFAKQLGFLEADEDGYFQKAFKE
                     LKVAENDYLEVTLHPVTKAFQDLMYSAVASSDYAHLLVMLVIAEGLYLDWGSKDLALP
                     EVYIHSEWINLHRGPFFAEWVQFLVDELNRVGKNREDLTELQQRWNQAVALELAFFDI
                     GYDV"
     gene            complement(2797..2886)
                     /locus_tag="VVO18_000323"
                     /pseudo
     CDS             complement(2797..2886)
                     /locus_tag="VVO18_000323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            2967..3749
                     /gene="thiM"
                     /locus_tag="VVO18_000324"
     CDS             2967..3749
                     /gene="thiM"
                     /locus_tag="VVO18_000324"
                     /EC_number="2.7.1.50"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HEU5585542.1"
                     /translation="MTSLKLLKEKAPLVICITNDVVKNFTANGLVALGASPAMSEFPA
                     DLEDLLKYAGGLLINIGTLTDENWKLYQAALKIAEKYNVPAVLDPVACGAGEYRKKVA
                     DDLINNYKLAAIRGNAGEIASLVGIDVASKGVDSAGVDNIDEIALAANEKFNIPIVVT
                     GEVDAIAVNGEVVTIHNGSAMMPKVIGTGCLLGAVVASFIGLEKGQELKSLETAMLVY
                     NIAGEIAEKRPNGHLPGTFKAEFINALYEITDEDVKEFKRVK"
     gene            3751..4380
                     /locus_tag="VVO18_000325"
     CDS             3751..4380
                     /locus_tag="VVO18_000325"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000468574.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEU5585543.1"
                     /translation="MFHKELLKLYFICGTTTCQGKNLYTVVEEALKGGITLFQFREKG
                     EGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRK
                     LMPDKIIGLSIRNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGLELMRKLL
                     PQMPLVAIGGIQTKHIKDIIKTNVDGVSIISAISYAKNIEKTVREMSEQ"
     regulatory      4589..4677
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            4939..5499
                     /locus_tag="VVO18_000326"
     CDS             4939..5499
                     /locus_tag="VVO18_000326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915269.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU5585544.1"
                     /translation="MLKKWQLKDVILLAFLSIFFGGVFVGSGYVYNILSLLLTPLGLQ
                     AFANEILFGLWCMAAPIAAIFVPRVGSATIGEVLAALAEVLYGSQFGLGALLSGLVQG
                     LGSEFGFIVTKNRYESWLSLTANSIGITLVSFVYEYIKLGYYAFSLPFVLSLLVVRFI
                     SVYFFCTILVRAIVKLYHQFATGGKA"
     gene            5500..6885
                     /locus_tag="VVO18_000327"
     CDS             5500..6885
                     /locus_tag="VVO18_000327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585545.1"
                     /translation="MGLELRAIQSPIFSEPFDFTFHAQAFTLLVGSSGSGKSSLFQVI
                     AQVSSLPYSGQVLIDGSEVSQLSIIARVQKVGILFQNPNHQFTMENLFEELIFTLENI
                     GYHLQEIDSKIAEVVQQCRCEAILHRPIHHLSGGEKQKAALAVLFAMNPRVYLLDEPF
                     ASIDRKSRIEILEILKELALDGKTVILCDHDLSDYKAYIDHMVELRDGKLREVFQIPS
                     YEMTQVASKEVASSPELFHMNRVTGELGNRPLFSIADFTFYQGISCILGDNGVGKSTL
                     FRSILQFQKYKGRIAWKGTVLKKKKSLYRDLTGVVQEAEKQFIRVSLREELQLDGPDS
                     ERNQRIFQALRYFDLEQAVDKSPYQLSGGQQKILQLLTILTSKASVILLDEPFAGLDD
                     RACHYFCKWIVEERNQGRSFLLISHRLDPLISVVDYWIEMTSQGLSHVKEVTITKPLT
                     SQSSNTQGEVR"
     gene            6887..7537
                     /locus_tag="VVO18_000328"
     CDS             6887..7537
                     /locus_tag="VVO18_000328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt ABC transporter permease"
                     /protein_id="HEU5585546.1"
                     /translation="MVKVATQTPIISLFLLILSLETSFIPSIALNLSVVAFCILFMLY
                     YRRFKMLAWMIILAILPSLANYWAVQLHGDASQAVMLGTRAFVTVCIGLVFVSSISLK
                     ELLLYLAQKGLSRSWSYALIVVFNSFPLIQQEIKSLKEACLLRGQELHFWSPLIYSKV
                     LMTVFRWRHLYLRALSAHGYDEHAQLKNSYRTFYIPKKTKLIYLLFFLLLQTSLFL"
     gene            7548..8240
                     /gene="tenA"
                     /locus_tag="VVO18_000329"
     CDS             7548..8240
                     /gene="tenA"
                     /locus_tag="VVO18_000329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864194.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiaminase II"
                     /protein_id="HEU5585547.1"
                     /translation="MEFTDIAMELSKKAWQASFHHPFILQLQEGNLEPAIFRYYLIQD
                     AYYLKAFSEIYHLLADKTSNQEMKRLLKQNAQGLVEGELFIRQQFFKEMEISDQEMEQ
                     HPIAPTCYHYISHIYRQFAEPNLAIAFASLLPCPWLYHDIGKSLNLKPSPNPLYQQWI
                     ETYITDELEQQIREEGALVNQLYRESDETDKQKMLDAFYISVHMEAKFWEMAYQHQTW
                     KSDLQSLEKGEE"
     gene            8245..8769
                     /gene="thiW"
                     /locus_tag="VVO18_000330"
     CDS             8245..8769
                     /gene="thiW"
                     /locus_tag="VVO18_000330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001225563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy coupling factor transporter S component
                     ThiW"
                     /protein_id="HEU5585548.1"
                     /translation="MRKHQLQVHKLTILSMMIALDVVLTPIFRIEGMAPMSSVVNILA
                     GIMMGPVYALAMATVTAFIRMTTQGIPPLALTGATFGALLAGLFYKYGRKFHYSALGE
                     ILGTGIIGSIVSYPVMVLFTGSAAKLSWFIYTPRFFGATLIGTAISFIAFRFLIKQEF
                     FKKVQGYFFSERID"
     gene            8769..9572
                     /locus_tag="VVO18_000331"
     CDS             8769..9572
                     /locus_tag="VVO18_000331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="HEU5585549.1"
                     /translation="MQEFTNPFPIDSSSLIHCMTNEISCEMLANGILALGCKPVMADD
                     PREVLDFTKQSQALFINLGHLSAEKEKAIRIAASYAAQVCLPMVVDAVGVTTSSIRKS
                     LVKDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYPG
                     MSFLVTGPKDLIVSENQVAVLENGCTELDWITGTGDLVGALTAVFLSQGKTGFEASCL
                     AVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEAYE"
     gene            9565..10197
                     /locus_tag="VVO18_000332"
     CDS             9565..10197
                     /locus_tag="VVO18_000332"
                     /EC_number="2.5.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine phosphate synthase"
                     /protein_id="HEU5585550.1"
                     /translation="MNREALRLYLVTNRYQDSVESFLAKVETACRSGVTIVQLREKNL
                     TTNQYYQLAKQVKEITDAYQVPLIIDDRLDVCLAVDAAGLHIGDDELPVSVARQVLGP
                     EKILGVTAKTVKRALEAEKSGADYLGTGAIFPTTTKENAPITLISTLKTICQTVAIPI
                     VAIGGLTSENIDQLMGTGIAGVAVVRDLMQAEDIEAKTQAFLTKLHDILS"
     gene            complement(10406..11197)
                     /gene="thiD"
                     /locus_tag="VVO18_000333"
     CDS             complement(10406..11197)
                     /gene="thiD"
                     /locus_tag="VVO18_000333"
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="HEU5585551.1"
                     /translation="MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVA
                     QNTRGVQLIEHVSPQMLKAQLESVFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPY
                     VLDPVMVATSGDALIDSNARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRA
                     GRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVI
                     TAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD"
     regulatory      complement(11281..11379)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            11563..11958
                     /locus_tag="VVO18_000334"
     CDS             11563..11958
                     /locus_tag="VVO18_000334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256226.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopY/TcrY family copper transport repressor"
                     /protein_id="HEU5585552.1"
                     /translation="MQISDAEWQVMKIIWMQGEQTSTDLIRVLAERFDWSKSTVQTLL
                     ARLVEKECLTRKKEGKFFVYSALLTLDQSRDLLVQDIKDKVCSRRIRNLLADLIVECE
                     FTQTDLEDLEAVISEKKSSAVTEVRCNCM"
     gene            11969..12340
                     /locus_tag="VVO18_000335"
     CDS             11969..12340
                     /locus_tag="VVO18_000335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cupredoxin domain-containing protein"
                     /protein_id="HEU5585553.1"
                     /translation="MLNSIVTIICIALIAFILFWFFKKPEKSGQKAQQKNGYQEIRVE
                     VMGGYTPELIVLKKSVPARIVFDRKDPSPCLDQIVFPDFGVHANLPMGEEYVVEIMPE
                     QAGEFGFACGMNMMHGKMIVE"
     gene            12350..14593
                     /locus_tag="VVO18_000336"
     CDS             12350..14593
                     /locus_tag="VVO18_000336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136280.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="HEU5585554.1"
                     /translation="MTEIVKASLENGIQKIRIRAEKGYHPAHIQLQKGIPAEITFHRA
                     TPSNCYKEILFEEEGILEPIGVDEEKVIRFTPQELGRHEFSCGMKMQKGSYTVVEKTR
                     KSLSLLQRFWITSIFTVPLVILMIGMLTGSISHQVMHWGTFLATTPIMLVAGKPYIQS
                     AWASFKKHNANMDTLVALGTLVAYFYSLVALFAGLPVYFESAGFILFFVLLGAVFEEK
                     MRKNTSQAVEKLLDLQAKTAEVLSDDSYVQVPLEQVKVGDLIRVRPGEKIAVDGVVVE
                     GVSSIDESMVTGESLPVDKTVGDTVIGSTINHSGTLVFRAEKVGSETVLAQIVDFVKK
                     AQTSRAPIQDLTDKISGIFVPVVVILGIMTFWVWFVLLRDSVVVLGASFVSSLLYGVA
                     VLIIACPCALGLATPTALMVGTGRSAKMGVLLKNGTVLQEIQKVQTLVFDKTGTLTEG
                     KPVVTDVIGDEVEVFGLAASLEDASQHPLAEAIVKRASEAGLEFQTVENFQTLHGKGV
                     SGRINGKQVLLGNAKMLDGMDISNTYQDKLEELEKEAKTVVFLAVDNEIKGLLALQDI
                     PKENAKLVISQLKKRGLRTVMLTGDNAGVARAIADQIGIEEVIAGVLPEEKAHEIHKL
                     QQSGKVAFVGDGINDAPALSVADVGIAMGAGTDIAIESADLVLTTNNLLGVVRAFDMS
                     KKTFHRILLNLFWAFIYNVVGIPIAAGVFSGVGLALNPELAGLAMAFSSVSVLTSSLL
                     LNFSKID"
     gene            14800..16575
                     /gene="spxB"
                     /locus_tag="VVO18_000337"
     CDS             14800..16575
                     /gene="spxB"
                     /locus_tag="VVO18_000337"
                     /EC_number="1.2.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate oxidase"
                     /protein_id="HEU5585555.1"
                     /translation="MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKD
                     IRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAIL
                     GSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAVSKKGPAVV
                     EIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGV
                     KAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLF
                     LGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPV
                     ESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTT
                     QTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPD
                     VITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFT
                     VDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKE
                     KYEAEELVPFRLFLEEEGLQSRAIK"
     gene            16686..17033
                     /locus_tag="VVO18_000338"
     CDS             16686..17033
                     /locus_tag="VVO18_000338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003017645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU5585556.1"
                     /translation="MNLNQLDIIVSNVPQVCADLEHILDKKADYADDGFAQFTIGSHC
                     LMLSQNHLVPLENFQSGIIIHIEVEDVDQNYKRLNELGIKVLHGPTVTDWGTESLLVQ
                     GPAGLVLDFYRMK"
     gene            complement(17150..18196)
                     /locus_tag="VVO18_000339"
                     /pseudo
     CDS             complement(17150..18196)
                     /locus_tag="VVO18_000339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            18261..18557
                     /locus_tag="VVO18_000340"
     CDS             18261..18557
                     /locus_tag="VVO18_000340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000380709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="family 1 glycosylhydrolase"
                     /protein_id="HEU5585557.1"
                     /translation="MDTPDENGYVADDYRITYLEAHIKAMRDAIYQDGVDLLGYTTWG
                     CIDPVSAGTGEMNKRYGFIYVDRDNVGNGVLKRSKKKSFYWYKDVIDSNGASIE"
     gene            18678..19622
                     /gene="manA"
                     /locus_tag="VVO18_000341"
     CDS             18678..19622
                     /gene="manA"
                     /locus_tag="VVO18_000341"
                     /EC_number="5.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mannose-6-phosphate isomerase, class I"
                     /protein_id="HEU5585558.1"
                     /translation="MSEPLFLQSVMQEKIWGGTKLRDEFGYDIPSEKVGEYWAISAHL
                     NGVSKVANGRYEGTDLATLYAEHRELFGNRPEPVFPLLTKILDANDWLSVQVHPDDAY
                     GLEHEGELGKTECWYIIAADEGSEIIYGHNAKSKEELRQQIEDKNWDTLLTKVPVKAG
                     DFFYVPSGTMHAIGTGILILETQQSSDTTYRVYDFDRKDDKGNLRELHLEKSIDVLNI
                     GEPANSRPVTVKADDLRSTLLVSNDFFAVYKWEITGKVDFEKTADYSLLSVLAGQGQL
                     TVDGKNYPIQKGRHFILPSDVEAWTLEGQGLELIVSHP"
     gene            complement(19643..20974)
                     /locus_tag="VVO18_000342"
     CDS             complement(19643..20974)
                     /locus_tag="VVO18_000342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-dependent transporter"
                     /protein_id="HEU5585559.1"
                     /translation="MVFLTDLRKHNRIVKSINQTEGYLTTQVAFSYFEKGDQSLTMSE
                     KSQWGSKLGFILASAGSVIGLGSVWKFPYMTAANGGGGFLLIFLISTILIGFPLLLAE
                     FALGRSAGVSAIKTFGKLGKNNKYNFIGWIGAFALFILLSFYSVIGGWILVYLGIEFG
                     KLFQLGGTGDYAQLFTSIISNPAIALVAQAAFILLNIFIVSRGVQKGIERASKVMMPL
                     LFIIFVVIIGRSLSLPNAMEGVLYFLKPDFSKLTSAGLLYALGQSFFALSLGVTVMMP
                     LLFIVLPQLFDKMPFGTIFYVLFLFATVTSSVVMLEINVGNITNQDNSKRAKWSVILG
                     ILTFVFGIPSALSYGVMADVHIFGKIFFDAMDFLASNLLMPFGALYLSLFTGYIFKKA
                     LAMEELHLDERAWKQGLFQVWLFLLRFFVSSFQSSSLWSSLPNLCNQKGLE"
     gene            21057..21811
                     /locus_tag="VVO18_000343"
                     /pseudo
     CDS             21057..21811
                     /locus_tag="VVO18_000343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000274794.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
     gene            complement(21831..22286)
                     /locus_tag="VVO18_000344"
                     /pseudo
     CDS             complement(21831..22286)
                     /locus_tag="VVO18_000344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081770.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
     gene            complement(22306..23481)
                     /locus_tag="VVO18_000345"
     CDS             complement(22306..23481)
                     /locus_tag="VVO18_000345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="HEU5585560.1"
                     /translation="MKHFDTIVIGGGPAGMMATISSSFYGQKTLLIEKNRKLGKKLAG
                     TGGGRCNVTNNGSLDNLLAGIPGNGRFLYSVFSQFDNHDIINFFTENGVKLKVEDHGR
                     VFPASDKSRTIIEALEKKITELGGQVATQIEIVSVKKVDDQFVLKSADQTFTCEKLIV
                     TTGGKSYPSTGSTGFGHEIARHFKHTITELEAAESPLLTDFPHKALQGISLDDVTLSY
                     GKHVITHDLLFTHFGLSGPAALRMSSFVKGGEVLSLDVLPQLSEKDLVTFLEENREKS
                     LKNALKTLLPERLAEFFVQGYPEKVKQLTEKEREQLVQSIKELKIPVTGKMSLAKSFV
                     TKGGVSLKEINPKTLESKLVPGLHFAGEVMDINAHTGGFNITSALCTGWVAGSLHYD"
     gene            complement(23540..24385)
                     /locus_tag="VVO18_000346"
     CDS             complement(23540..24385)
                     /locus_tag="VVO18_000346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219932.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU5585561.1"
                     /translation="MTWKIIADSGCDYRQLPTPAINTTFVSVPLTIQVADQVFVDDAS
                     LDIDQMMETMYATAEASKSACPSPDDYLRAFEGAKNIFLVTITGTLSGSHNSAQLAKN
                     IYLEDHPDTKIHVIDSLSAGGEVDLLVEKLNDLIDQGLSFEEVVEAITAYQEKTKLLF
                     VLAKVDNLVKNGRLSKLIGTVVGLLNIRMVGKASETGTLELLQKARGSKKSVQAAYDE
                     LVKAGYAGGRIVMAQRNNEKCCQQLSERIRETFPQADIKILPTSGLCSFYAEEGGLLM
                     GYEID"
     gene            24510..25067
                     /locus_tag="VVO18_000347"
     CDS             24510..25067
                     /locus_tag="VVO18_000347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEU5585562.1"
                     /translation="MSERRISEKSLENLRKSNQESNLLTREAIETALLQLLEKKELTK
                     ISISELVKRAGVSRAAFYRNYDSKEEILESVFKRTVHNIMEQLHHYDLKTDLYLVWVH
                     LFREARKEARVIQLALDYHLEKIFVQAMQEFLEKYHGKSKGVSSYLHSFWSSAIVSVL
                     LKWIKDGMKVPAEKIADLGLPFFKK"
     gene            25086..25553
                     /locus_tag="VVO18_000348"
     CDS             25086..25553
                     /locus_tag="VVO18_000348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000138511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine/deoxycytidylate deaminase family
                     protein"
                     /protein_id="HEU5585563.1"
                     /translation="MTEKRLAWDEYFAAQALLIANRSTCKRAKVGAILVKDNKVISTG
                     YNGSVSGTEHCIDHECLVIEGHCVRTLHAEVNAILQGAERGVPKGFTAYVTHFPCLNC
                     TKQLLQVGCKRVVYINQYRMDDYAQYLYQEKGTELTHLPLETVQTALKEADLM"
     gene            25642..26271
                     /gene="upp"
                     /locus_tag="VVO18_000349"
     CDS             25642..26271
                     /gene="upp"
                     /locus_tag="VVO18_000349"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002883819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil phosphoribosyltransferase"
                     /protein_id="HEU5585564.1"
                     /translation="MGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEV
                     LRDLPLEDVEIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGM
                     YRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCL
                     VSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK"
     gene            26445..27035
                     /gene="clpP"
                     /locus_tag="VVO18_000350"
     CDS             26445..27035
                     /gene="clpP"
                     /locus_tag="VVO18_000350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease proteolytic subunit
                     ClpP"
                     /protein_id="HEU5585565.1"
                     /translation="MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIA
                     QLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIA
                     SSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
                     SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN"
     gene            27114..27362
                     /locus_tag="VVO18_000351"
     CDS             27114..27362
                     /locus_tag="VVO18_000351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbG family protein"
                     /protein_id="HEU5585566.1"
                     /translation="MFEKVNRSGLIIYLYYNRDAKKLQDYGDITYHSKKHRYLQLYVP
                     TQEVEQLVGRLSKEKFIKKVRVCHIQELETPFVGNLYR"
     gene            27464..28624
                     /locus_tag="VVO18_000352"
     CDS             27464..28624
                     /locus_tag="VVO18_000352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5585567.1"
                     /translation="MKKKFALSFVALASVALLAACGEVKSGAVNTAGNSVEEKTIKIG
                     FNFEESGSLAAYGTAEQKGAQLAVDEINAAGGIDGKQIEVVDKDNKSETAEAASVTTN
                     LVTQSKVSAVVGPATSGATAAAVANATKAGVPLISPSATQDGLTKGQDYLFIGTFQDS
                     FQGKIISNYVSEKLNAKKVVLYTDNASDYAKGIAKSFRESYKGEIVADETFVAGDTDF
                     QAALTKMKGKDFDAIVVPGYYNEAGKIVNQARGMGIDKPIVGGDGFNGEEFVQQATAE
                     KASNIYFISGFSTTVEVSAKAKAFLDAYRAKYNEEPSTFAALAYDSVHLVANAAKGAK
                     NSGEIKDNLAKTKDFEGVTGQTSFDADHNTVKTAYMMTMNNGKVEAAEVVKP"
     gene            28892..29761
                     /locus_tag="VVO18_000353"
     CDS             28892..29761
                     /locus_tag="VVO18_000353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEU5585568.1"
                     /translation="MLQQLVNGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGA
                     FIGYFLINSFQMNFFVALIVAMLATAILGVVIEFLAYRPLRHSTRIAVLITAIGVSFL
                     LEYGMVYLVGANTRAFPQAIQTVRYDLGPISLTNVQLMILGISLILMILLQVIVQKTK
                     MGKAMRAVSVDSDAAQLMGINVNRTISFTFALGSALAGAAGVLIALYYNSLEPLMGVT
                     PGLKSFVAAVLGGIGIIPGAALGGFVIGLLETFATAFGMSDFRDAIVYGILLLILIVR
                     PAGILGKNVKEKV"
     gene            29765..30721
                     /locus_tag="VVO18_000354"
     CDS             29765..30721
                     /locus_tag="VVO18_000354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="HEU5585569.1"
                     /translation="MKENLKVNILWLLLLLAGYSLISVLVSVGVLNLFYVQILQQIGI
                     NIILAVGLNLIVGFSGQFSLGHAGFMAIGAYAAAIIGSKSPTYGAFFGAMLVGALLSG
                     AVALLVGIPTLRLKGDYLAVATLGVSEIIRIFIINGGSLTNGAAGILGIPNFTTWQMV
                     YFFVVITTIATLNFLRSPIGRSTLSVREDEIAAESVGVNTTKIKIIAFVFGAITASIA
                     GSLQAGFIGSVVPKDYTFINSINVLIIVVFGGLGSITGAIVSAIVLGILNMLLQDVAS
                     VRMIIYALALVLVMIFRPGGLLGTWELSLSRFFKKSKKEEQN"
     gene            30721..31485
                     /locus_tag="VVO18_000355"
     CDS             30721..31485
                     /locus_tag="VVO18_000355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002913097.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585570.1"
                     /translation="MALLEVKQLTKHFGGLTAVGDVTLELNEGELVGLIGPNGAGKTT
                     LFNLLTGVYEPSEGTVTLDGHLLNGKSPYKIASLGLGRTFQNIRLFKDLTVLDNVLIA
                     FGNHHKQHVFTSFLRLPAFYKSEKELKAKALELLKIFDLDGDAETLAKNLSYGQQRRL
                     EIVRALATEPKILFLDEPAAGMNPQETAELTELIRRIKDEFKITIMLIEHDMNLVMEV
                     TERIYVLEYGRLIAQGTPDEIKTNKRVIEAYLGGEA"
     gene            31485..32195
                     /locus_tag="VVO18_000356"
     CDS             31485..32195
                     /locus_tag="VVO18_000356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000062217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585571.1"
                     /translation="MSMLKVENLSVHYGMIQAVRDVSFEVNEGEVVSLIGANGAGKTT
                     ILRTLSGLVRPSSGKIEFLGQEIQKMPAQKIVAGGLSQVPEGRHVFPGLTVMENLEMG
                     AFLKKNREENQANLKKVFSRFPRLEERKNQDAATLSGGEQQMLAMGRALMSTPKLLLL
                     DEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNANKALAISNRGYVLETGKIVLSG
                     TGKELASSEEVRKAYLGG"
     gene            32609..33265
                     /locus_tag="VVO18_000357"
     CDS             32609..33265
                     /locus_tag="VVO18_000357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU5585572.1"
                     /translation="MAVKDFMTRKVVYISPDTTVSHAADLMREQGLHRLPVIENDQLV
                     GLVTEGTIAQASPSKATSLSIYEMNYLLNKTKVKDVMIRDVVTVSGYASLEDATYLML
                     KNKIGILPVVDNYQVYGVITDRDVFQAFLEIAGYGEEGIRVRFVTEDEVGVLGKIVSL
                     IVEENLNISHTVNIPRKDGKVIIEVQIDESIDLPALKEKFEANGIQVEEIARTSAKVL
                     "
     gene            33373..34468
                     /gene="prfB"
                     /locus_tag="VVO18_000358"
     CDS             join(33373..33444,33446..34468)
                     /gene="prfB"
                     /locus_tag="VVO18_000358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511312.1"
                     /ribosomal_slippage
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 2"
                     /protein_id="HEU5585573.1"
                     /translation="MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPD
                     FWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAE
                     LDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKV
                     EVLDYQAGDEAGIKLVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVE
                     VMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRT
                     QYGNRDRAMKMLQAKLYQMEQDKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDH
                     RTSFEVAQVDKVMDGDLDGFIDAYLKWRIS"
     gene            34486..35178
                     /gene="ftsE"
                     /locus_tag="VVO18_000359"
     CDS             34486..35178
                     /gene="ftsE"
                     /locus_tag="VVO18_000359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division ATP-binding protein FtsE"
                     /protein_id="HEU5585574.1"
                     /translation="MSIIEMRDVVKKYDNGTTALRGVSVSVQPGEFAYIVGPSGAGKS
                     TFIRSLYREVKIDKGSLSVAGFNLVKIKKKDVPLLRRSVGVVFQDYKLLPKKTVYENI
                     AYAMEVIGENRRNIKRRVMEVLDLVGLKHKVRSFPNELSGGEQQRIAIARAIVNNPKV
                     LIADEPTGNLDPDNSWEIMNLLERINLQGTTILMATHNSQIVNTLRHRVIAIENGRVV
                     RDESKGEYGYDD"
     gene            35171..36097
                     /locus_tag="VVO18_000360"
     CDS             35171..36097
                     /locus_tag="VVO18_000360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5585575.1"
                     /translation="MISRFFRHLFEALKSLKRNGWMTVAAVSSVMITLTLVAIFASVI
                     FNTAKLATDIENNVRVVVYIRKDVEDNSQTIEKEGQTVTNNDYHKVYDSLKNMSTVKS
                     VTFSSKEEQYEKLTEIMGDNWKIFEGDANPLYDAYIVEANTPNDVKTIAEDAKKIEGV
                     SEVQDGGANTERLFKLASFIRVWGLGIAALLIFIAVFLISNTIRITIISRSREIQIMR
                     LVGAKNSYIRGPFLLEGAFIGLLGAIAPSVLVFIVYQIVYQSVNKSLVGQNLSMISPD
                     LFSPLMIALLFVIGVFIGSLGSGISMRRFLRI"
     gene            36383..38563
                     /locus_tag="VVO18_000361"
     CDS             36383..38563
                     /locus_tag="VVO18_000361"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000974069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU5585576.1"
                     /translation="MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVM
                     INPTFTPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINR
                     ITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGA
                     TAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWI
                     ANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFG
                     QDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNV
                     DADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVN
                     LRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPG
                     RNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADK
                     VGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEA
                     QQNTVHFKDLTEEVYSVADGQVVALEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGT
                     VSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADL
                     NAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL"
     gene            38615..39430
                     /locus_tag="VVO18_000362"
     CDS             38615..39430
                     /locus_tag="VVO18_000362"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEU5585577.1"
                     /translation="MKFLTLNTHSWMEKEAEEKFQILLEDILEKDYDLICFQEINQEM
                     TSSEVEVNDLYQALPAAEPIHQDHYVRLLVEKLLEQGKNYYWTWAYNHIGYDRYHEGV
                     AILSKTPIEAREILVSDVDDPTDYHTRRVALAETVVDGKELAVASVHLSWWDKGFQEE
                     WARFEAVLKKLNKPLLLAGDFNNPAGQEGYQAILASPLGLQDAFEVAQEKSGSYTVPP
                     EIDGWKGNTEPLRIDYVFTTKELAVENLHVVFDGNKSPQVSDHYGLNAMLNWK"
     gene            39570..40913
                     /locus_tag="VVO18_000363"
     CDS             39570..40913
                     /locus_tag="VVO18_000363"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU5585578.1"
                     /translation="MSFTKFQFKNYIREALKELKFTTPTEVQDKLIPIVLAGRDLVGE
                     SKTGSGKTHTFLLPIFQQLDEASDSVQAVITAPSRELATQIYQVARQISAHSDVEVRV
                     VNYVGGTDKARQIEKLASNQPHIVIGTPGRIYDLVKSGDLAIHKAKTFVVDEADMTLD
                     MGFLETVDKIAGSLPKDLQFMVFSATIPQKLQPFLKKYLSNPVMEKIKTKTVISDTID
                     NWLISTKGHDKNAQIYQLTQLMQPYLAMIFVNTKTRADELHSYLTAQGLKVAKIHGDI
                     APRERKRIMNQVQNLDFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTG
                     RNGLPGTAITLYQPSDDSDIRELEKLGIKFSPKIVKDGEFQDTYDRDRRANREKKQDK
                     LDIEMIGLVKKKKKKVKPGYKKKIQWAVDEKRRKTKRAENRARGRAERKAKRQTF"
     gene            41290..42480
                     /locus_tag="VVO18_000364"
     CDS             41290..42480
                     /locus_tag="VVO18_000364"
                     /EC_number="2.5.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine adenosyltransferase"
                     /protein_id="HEU5585579.1"
                     /translation="MSERKLFTSESVSEGHPDKIADQISDAILDAILAKDPEAHVAAE
                     TAVYTGSVHVFGEISTNAYVDINRVVRDTIAEIGYTNTEYGFSAETVGVHPSLVEQSP
                     DIAQGVNEALEVRGNADQDPLDLIGAGDQGLMFGFAVDETEELMPLPIALSHKLVRRL
                     AELRKSGEISYLRPDAKSQVTVEYDENDRPVRVDTVVISTQHDPEATNEQIHQDVIDK
                     VIKEVIPSSYLDDKTKFFINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYSRHGGGAFS
                     GKDATKVDRSASYAARYIAKNIVAADLAKKAEVQLAYAIGVAQPVSVRIDTFGTGTVA
                     ESQLEKAARQIFDLRPAGIIQMLDLKRPIYRQTSAYGHMGRTDIDLPWERLDKVDALK
                     EAVK"
     gene            43033..43968
                     /locus_tag="VVO18_000365"
     CDS             43033..43968
                     /locus_tag="VVO18_000365"
                     /EC_number="1.3.98.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotate oxidase"
                     /protein_id="HEU5585580.1"
                     /translation="MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVT
                     KTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLV
                     GMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
                     PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGI
                     GGEYIKPTALANVHAFYQRLNPQIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKE
                     GVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID"
     gene            44002..45039
                     /locus_tag="VVO18_000366"
     CDS             44002..45039
                     /locus_tag="VVO18_000366"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit delta"
                     /protein_id="HEU5585581.1"
                     /translation="MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDS
                     ADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSF
                     EEYLDNPSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
                     QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIF
                     DLTQFILTKKMDQARDLVRDLTLQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQI
                     ASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFE
                     KALLQIASQVN"
     gene            45212..45817
                     /locus_tag="VVO18_000367"
     CDS             45212..45817
                     /locus_tag="VVO18_000367"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="superoxide dismutase"
                     /protein_id="HEU5585582.1"
                     /translation="MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALE
                     KHPEIGEDLEALLADVESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAA
                     IDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
                     GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK"
     gene            45974..46504
                     /locus_tag="VVO18_000368"
     CDS             45974..46504
                     /locus_tag="VVO18_000368"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YutD family protein"
                     /protein_id="HEU5585583.1"
                     /translation="MRKEIAPELYNYNKFPGPEFHLHGDKVETEGIAFSLVENIKDAF
                     DVTTFNQRFSEVLTKFDYIVGDWSNEQLRLRGFYKDDRTEEKLEKISRLQDYLLEYCS
                     YGCAYFVLENEAPKRASFDKKMRKTEEETPSRKGKKPTQTKRKSNADKKNRRRQKDQH
                     SQKEDKGQRHFVIRQK"
     gene            46525..47427
                     /locus_tag="VVO18_000369"
     CDS             46525..47427
                     /locus_tag="VVO18_000369"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S rRNA methyltransferase"
                     /protein_id="HEU5585584.1"
                     /translation="MKPSIHSLAHQTMQKWVLEQGEKKFRADQIWEWLYRKRVQSFEE
                     MTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLS
                     VCVTTQVGCNIGCTFCASGLIKKQRDLNNGEIVAQIMLVQKYFADEGVQVNLAVSLHA
                     PNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDGVEQALELAE
                     LLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGGNCVVRQEHGTDID
                     AACGQLRFNTMKRDRQKAVAAVNP"
     gene            47427..47909
                     /locus_tag="VVO18_000370"
     CDS             47427..47909
                     /locus_tag="VVO18_000370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000976721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEU5585585.1"
                     /translation="MMKKTYNHILVWGVIFYSICIVCFCFTPQEQSTVGVGTPGIQHL
                     GRLVFLLTPFNSLWKLGEVSDIGQLCWIFLQNILNVFLFFPLIFQLLYLFPNLRKTKK
                     VLLFSFLVSLGIECTQLILDFFFDFNRVFEIDDLWTNTLGGYLAWLLYKRLHKNKVRN
                     "
     gene            47911..49452
                     /locus_tag="VVO18_000371"
     CDS             47911..49452
                     /locus_tag="VVO18_000371"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002918612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU5585586.1"
                     /translation="MSILEVKNLSHGFGDRAIFEDVSFRLLKGEHIGLVGANGEGKST
                     FMSIVTGKMLPDEGKVEWSKYVTAGYLDQHSVLAERQSVRDVLRTAFDELFKAEARIN
                     DLYMKMAEDGADVDALMEEVGELQDRLESRDFYTLDAKIDEVARALGVMDFGMDTDVT
                     SLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDI
                     PFLNDVINIVYHVENQQLTRYSGDYYQFQEVYAMKKSQLEAAYERQQKEIADLKDFVA
                     RNKARVATRNMAMSRQKKLDKMDIIELQSEKPKPSFDFKPARTPGRFIFQAKNLQIGY
                     DRPLTKPLNLTFERNQKVAIIGANGIGKTTLLKSLLGIISPIAGEVERGDYLELGYFE
                     QEVEGGNRQTPLEAVWNAFPALNQAEVRAALARCGLTTKHIESQIQVLSGGEQAKVRF
                     CLLMNRENNVLVLDEPTNHLDVDAKDELKRALKEYRGSILMVCHEPDFYEGWIDQIWD
                     FNNLT"
     gene            complement(49508..50311)
                     /locus_tag="VVO18_000372"
     CDS             complement(49508..50311)
                     /locus_tag="VVO18_000372"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731914.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidylprolyl isomerase"
                     /protein_id="HEU5585587.1"
                     /translation="MKKLATLLLLSTVALAGCSSVQRSLRGDDYVDSSLAAEESSKVA
                     AQSAKELNDALTNENANFPQLSKEVAEDEAEVILHTSQGDIRIKLFPKLAPLAVENFL
                     THAKEGYYNGITFHRVIDGFMVQTGDPKGDGTGGQSIWHDKDKTKDKGTGFKNEITPY
                     LYNIRGALAMANTGQPNTNGSQFFINQSSTDTSSKLPTSKYPQKIIEAYKEGGNPSLD
                     GKHPVFGQVIDGMDVVDKIAKAEKDEKDKPTTAITIDSIEVVKDYDFKS"
     gene            complement(50395..50607)
                     /locus_tag="VVO18_000373"
     CDS             complement(50395..50607)
                     /locus_tag="VVO18_000373"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585588.1"
                     /translation="MSFYGLFYNGIAITPNTYLSAWFVNFIAALPLNFLIVEPIARFI
                     LSSFQKPFTGEEVEDFQDDDEIPTII"
     gene            complement(51086..51295)
                     /locus_tag="VVO18_000374"
     CDS             complement(51086..51295)
                     /locus_tag="VVO18_000374"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000953868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585589.1"
                     /translation="MLSVNTILEKFYKKHQVKPFISPERELDTWLLSPKPVPKRNMDL
                     LVDDSLAGDIILLWRIQFGTFTTET"
     gene            51465..51737
                     /gene="rpsP"
                     /locus_tag="VVO18_000375"
     CDS             51465..51737
                     /gene="rpsP"
                     /locus_tag="VVO18_000375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002884675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S16"
                     /protein_id="HEU5585590.1"
                     /translation="MAVKIRLTRMGSKKKPFYRINVADSRSPRDGRFIETVGTYNPLV
                     AENQVTLKEDRVLAWLANGAQPSDTVRNILSKEGVLKKFHDSKFSK"
     gene            51757..51996
                     /locus_tag="VVO18_000376"
     CDS             51757..51996
                     /locus_tag="VVO18_000376"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="KH domain-containing protein"
                     /protein_id="HEU5585591.1"
                     /translation="MDTIENLIIAIVKPLISQPDALTIKIEDTPEFLEYHLNLDQSDV
                     GRVIGRKGRTISAIRTIVYSVPTEYKKVRIVIDEK"
BASE COUNT        15727 a         9682 c        11360 g        15426 t
ORIGIN      
        1 aaaaaattaa taagtgggat aggaagttag cgtcaactag gatagtatct tgcttaaaca
       61 gtatatatgg gactgatata agtccatagg tcctattaga ggatgttctg gtgtcttatt
      121 cacttgtttt tttatagtat tagtagatag aatcagcaaa taaaaaagta gttcaaatgc
      181 ctggcagcaa aaaatctcaa cgattcactt aatatagact aaagtttaga gtttaaggaa
      241 agtagggcta gtatattgta tgaaaaaata agatggtttt taagcaaaac tcttgaaaat
      301 gattgaaaaa agagttatta tagttgtgta gtaaaaagca aacgcttact taatcaagga
      361 gggcatttta tgtcatacaa aacaagcaat gcagaaggtc atgtagactt catcaatacc
      421 tatgatttgg agccaatggc gcaacaagtt attcctaaag cagcatttgg ctatatcgct
      481 agtggggcgg aagatacttt cactttaaga gagaatatcc gcgcctttaa ccacaaactc
      541 atcgttcctc atacactttg cgatgttgaa aatccaagta cagagattga atttgcaggt
      601 gaaaaactat cttcaccaat cattatggcg cctgttgcgg ctcataaatt ggcaaatgaa
      661 cagggggaag tggcgactgc gcgtggtgtg catgagtttg gttctcttta tacaaccagc
      721 tcttactcta ctgttgacct tccagagatt tctgaagccc ttcaagggac accccattgg
      781 ttccaatttt actttagtaa ggatgacggt atcaaccgcc acatcatgga ccgtgtgaag
      841 gctgaaggtt ataaagcgat tgtcttgacg gcagatgcta ctgtaggggg gaatcgtgaa
      901 gtggataagc gtaatggttt tgtcttccca gttggcatgc cgattgttga agaatacctg
      961 ccagaaggtg ctggtaaatc aatggacttt gtttacaaat cagctaaaca acgcttgtct
     1021 ccacgcgatg tagaatttat cgctgaatac tctggtcttc ctgtgtatgt caagggacca
     1081 caatgccgtg aggacgttga acgttcactt gctgcaggag cttctggtat ctgggtaacc
     1141 aaccacggtg gtcgtcaaat cgacggtgga ccagctgcct ttgactcgct tcaagaagtg
     1201 gcagaagcag ttgatagacg tgtgccgatt gtctttgact ctggtgttcg tcgtggtcaa
     1261 cacgtcttta aagccttggc ttcaggagca gacttggtag ctattggtcg ccctgttatt
     1321 tatggcttgg ctctcggtgg tagtgtcggt gtgcgtcaag tctttgaaca cttgaatgcg
     1381 gaattgaaga cagttatgca attgtctgga gctcagacca ttgaagatgt caaacacttt
     1441 aagctccgtc acaatccata caacccaacc ttcccagttg accctcgtga cttaaaattg
     1501 tattgataaa acagattgcc tccactgaat gtggaggttt ttcttcgtgt attggaagaa
     1561 taaatcgcta tcgaaaacta taataaaatg aaataagaat aggacaaatc aatcaggaca
     1621 gttaaatcga tttctaacaa tgttttagaa gtagaggtgt actattctag tttcaatcta
     1681 ctatataaag atatttttcg gtcaaatatc ttgctagggc tttcattttt tgctatactg
     1741 gttcagtaat taaataatag agacatttgg ggtgctttaa gctgagatga tacccattga
     1801 acctgataca gttaagactg gcgaagggaa atgtgaaacg ttttttcgta tggcgaaatg
     1861 aacgatctaa tcttgtaagt caactctaat tcttgattgt aattggagtt ttttgtttat
     1921 ataaactgga taggcttgtt tagttagctt ctctgcaaat gctctcgatg tgctttaaaa
     1981 ggatcaagtg gaattacgat tttgcttgat atttcttggt gttttattaa ttactaacaa
     2041 gtaaagagag gagaagtaaa tatggaaaca caagactatg catttcagcc aggtttgact
     2101 gttggagaat tattaaaaag cagtcagaag gattggcagg ctgcaatcaa tcatcgtttt
     2161 gttaaggaac tttttgcggg gacaattgag aataaggtct taaaggacta tctgattcaa
     2221 gattatcact tctttgatgc cttcttatcc atgctgggtg cctgcgtagc tcacgcagat
     2281 aaacttgaat ctaagcttcg ttttgccaag caactaggct ttcttgaagc agatgaagat
     2341 ggttatttcc aaaaggcttt taaagagtta aaagtagcag agaatgacta tctagaagtg
     2401 actttgcacc ctgtaacaaa agcctttcag gatctaatgt attcggcggt ggcttcatca
     2461 gactatgccc atcttttggt catgctggtc attgcagaag gtctctattt agactggggt
     2521 tctaaagatt tggctttacc tgaagtctat attcattcgg aatggatcaa tctccacaga
     2581 ggtcctttct ttgcagagtg ggttcaattt ctggttgacg aactcaatcg tgtcggtaaa
     2641 aatcgagaag atttgacaga acttcagcaa cgctggaatc aagcagtcgc tttagaatta
     2701 gctttttttg atattggtta cgatgtctag agaaggctca tgatatttac aaatttgatg
     2761 aggtaagact cttcgaaaat ctcttcgaac cacgtcagtt ctatccacaa cctcaaaaca
     2821 gtgttttgag caacctgcgg ttagcctcct agtttgctct ttgattttca ttgagtataa
     2881 atcattcaat gtaaatgaaa aaaattctca actaaagata aatcgaaatc agtagatcgt
     2941 ataaagtgaa aaggaaggat ttcaatatga caagtttaaa attattaaaa gaaaaagcac
     3001 cattggtcat ttgtataacc aatgatgtag taaaaaattt cacagcaaat ggattagtag
     3061 cactgggcgc ctcaccagcc atgagtgagt ttccagcaga tttagaggat ttgttaaagt
     3121 atgctggtgg tttattaata aacataggaa cattgacaga tgaaaattgg aaattatacc
     3181 aagctgctct gaaaattgcg gagaaatata atgtcccagc agttttagat cctgtagcct
     3241 gtggagcagg agaatataga aaaaaagtag cagatgatct aatcaacaat tataaactag
     3301 cagcgattag aggaaatgct ggcgagattg cctctttagt aggaatagat gtggcatcta
     3361 aaggagtaga tagtgcgggc gtagataata ttgacgaaat tgctctagca gcaaatgaga
     3421 agttcaatat tccaatagta gtaacaggtg aagtggatgc cattgctgtt aatggagaag
     3481 tggtaacgat tcataatggt agtgctatga tgccgaaagt cattgggaca ggatgcttat
     3541 taggagctgt agtagcaagc tttatcggac tggaaaaagg tcaagaattg aaatcattag
     3601 aaacagcaat gttggtttac aatatcgctg gagaaatagc agaaaaacgt cccaatggac
     3661 atcttcctgg aacatttaaa gctgaattta taaatgcctt atacgagatt acagatgaag
     3721 atgtaaagga attcaaaaga gtgaagtaag atgtttcata aagaattact aaaactatat
     3781 tttatttgtg gaacgactac ttgccaagga aaaaatctat atacagtcgt tgaggaagcc
     3841 ttaaaaggtg gtataacctt atttcaattt cgagaaaaag gtgagggtgc tttagaaggc
     3901 ttagaaaaac ttgagctagc tatccaaatt aaagaacttt gtaaaaaata caatgttcca
     3961 tttatcgtta atgacgatat agatttagca atggaaattg acgccgatgg cgtacatgta
     4021 ggtcaagatg atattggtgt tgatgaaatt agaaaattga tgccagataa aataattggt
     4081 ctttctataa gaaacgaaga agaatttcaa caatcaaaag ttgaatatgt agattatgta
     4141 ggtgttgggc ctgtatttga tacccagtca aaagatgatg ctggtggtgc tataggttat
     4201 gaaggtcttg aattgatgag aaaactattg ccacaaatgc ctttagttgc aattggtggg
     4261 atacagacga aacatattaa agacattata aagaccaatg ttgacggcgt ttcaatcatt
     4321 tcggcaatat cgtatgcaaa aaatatagaa aaaactgttc gggaaatgag tgaacaatag
     4381 atatctatcc ttggattcta agtaagtagg attttccttt tttaaaaagc tatgtctaga
     4441 ttcagcttga atggctaatt catcaaacag gtcatttgtt ttttgcaaaa gaaagatctg
     4501 ctgtctttgt gagtgcaagg ctgtatttcc agttcaattt cttgaactag tataaaatgt
     4561 gtgttataat aatcacataa ttaaataata aaggcatttg gggtgcttta ggctgagatg
     4621 atacccattg aacctgatac agttaagact ggcgaaggga aatgtgaaat gtttttttcg
     4681 tatgtcgaaa agaactgtct aatcttgtaa gctgaactct aattcgtatc tgtaattaga
     4741 gttttttctt ttacgaaact ggatgaagat gatatagtag attgaaataa gatgcgaaca
     4801 aatcaattag aaaattcaaa ttaatttcta gaaatatttt agcattcctg tgtactgttc
     4861 taaattcaat ctgctataca aagtatttag gtcggtcttc ttgagtgccc cacttttctt
     4921 ttaaaaaagg agttttttat gttgaaaaaa tggcagttaa aagatgttat cttgcttgct
     4981 ttcttgtcta tcttttttgg tggggttttc gttggttcag gatatgtgta taatattctc
     5041 agtctactct taacacctct tggtttgcag gcctttgcca atgaaatcct cttcggtctc
     5101 tggtgtatgg ctgcgcccat tgctgccatc tttgttccga gagtcggaag tgcaacgatt
     5161 ggagaagtgc tagctgcgct tgctgaagtc ctttatggta gccaatttgg tctaggagct
     5221 cttttgtctg gcttagttca aggtttggga agtgaatttg gttttatcgt aactaagaat
     5281 cgctatgaaa gttggctctc tctaactgct aatagtattg ggattacgct tgttagcttt
     5341 gtctatgaat acattaagtt aggttactac gccttttccc ttccgtttgt cctttcctta
     5401 cttgtggtac gttttatttc tgtttatttc ttctgtacca tcttggttcg tgccattgtc
     5461 aaactctatc atcagtttgc aactggagga aaagcataga tgggtctgga actacgagcg
     5521 attcagtccc caatcttctc tgagccgttt gattttactt ttcatgcgca agcctttacc
     5581 ttgttagttg ggagcagtgg ttcaggaaaa tccagccttt ttcaagtcat tgcccaagtc
     5641 agttctcttc cctatagtgg tcaagtcctg atagatggga gcgaggtcag tcagctttct
     5701 atcatcgcac gtgtccagaa ggttggcatt ctctttcaaa atcccaatca tcaatttacc
     5761 atggagaact tgtttgagga gctgattttc accttggaga atatcggcta tcaccttcag
     5821 gaaattgatt ctaaaatagc agaggttgtc cagcaatgtc gttgcgaggc aatcttacac
     5881 cgtcccattc atcacctatc aggtggggaa aagcaaaaag cagcgctggc tgtcctcttt
     5941 gccatgaatc ctagggtcta tctcttggat gagcccttcg cttctattga ccgcaagagc
     6001 agaatcgaga tattggagat tctaaaagag ttggctcttg atgggaagac agttattttg
     6061 tgcgaccatg atttatctga ctataaagcc tatatcgacc atatggttga gctaagagac
     6121 ggaaaactaa gggaagtgtt tcaaatccct tcctatgaga tgacacaggt tgcttcaaag
     6181 gaagttgctt ctagcccgga actattccat atgaaccgtg tgactggtga gcttggtaat
     6241 cgccccctct tttcaattgc tgatttcaca ttctatcaag ggatttcctg tatcctgggt
     6301 gacaatggtg tcgggaaatc aaccctcttt cgctctattc ttcaatttca aaagtataag
     6361 gggcgcattg catggaaggg gacagtcctg aaaaagaaaa agagtttgta ccgtgatctg
     6421 acgggtgttg ttcaggaagc tgagaagcag tttatccgag tcagtctgcg agaggagctt
     6481 caattagatg gacctgattc tgaaagaaat cagcggattt ttcaagcttt acgatatttt
     6541 gatttggagc aggcagtcga taagagtccc tatcaattaa gtggtggtca gcaaaaaatt
     6601 cttcagctcc tgaccatctt gaccagtaag gcttccgtga tcttgctaga tgaacctttt
     6661 gcaggtttgg atgatagagc ctgccattat ttttgcaagt ggattgtgga ggagaggaat
     6721 caaggaagaa gttttctgct cattagtcat cgtttagacc ctttgatttc tgtggttgat
     6781 tattggattg agatgactag tcaggggctc agtcatgtga aagaagtgac cattaccaaa
     6841 ccacttacat ctcagagtag caatacccaa ggggaggtga gatagtatgg tcaaagtagc
     6901 aacccagaca ccgattatca gtctcttctt gctgatttta tccttggaaa catctttcat
     6961 tccttcgatt gctctgaatc tttcggtagt cgcattttgt attctcttta tgctctatta
     7021 ccgtcgattt aaaatgttag cttggatgat catacttgcc attttaccat ctttggccaa
     7081 ctactgggca gttcagttac acggagatgc ttcacaggca gtcatgcttg gaacgagggc
     7141 ctttgtgaca gtttgtatcg gccttgtctt tgtttcctct atttcactaa aagagcttct
     7201 cttgtacttg gctcaaaagg ggctatcacg ctcttggtcc tatgccttga ttgtggtatt
     7261 caattccttt cctctcattc agcaagaaat caagtccctc aaagaagctt gcctattacg
     7321 tggtcaagaa ctgcattttt ggtcgccctt gatttacagt aaggttctga tgacagtctt
     7381 taggtggcgc catctttacc tgagagctct gtctgctcat ggatatgacg aacatgcaca
     7441 gttgaagaat agctatcgga ctttttatat tcctaaaaaa acaaaattaa tctacctgct
     7501 tttcttttta ttgcttcaaa ccagtctatt tttataaagg agttattatg gaatttacag
     7561 atattgcgat ggaattatcc aagaaagctt ggcaggcttc ctttcatcat ccctttattt
     7621 tacaattaca agaggggaat ttagaacctg ccattttccg ctattacctg attcaggatg
     7681 cctactatct gaaggccttc tcagaaatct atcatctttt ggctgataag acttcaaacc
     7741 aagagatgaa aagactcttg aaacaaaatg ctcagggttt agtggagggt gagttattta
     7801 ttcgccaaca atttttcaag gaaatggaaa tcagcgacca ggaaatggag caacatccaa
     7861 ttgctccaac ctgttatcat tacatttctc atatttatag gcaatttgca gaaccgaact
     7921 tagccatcgc ttttgcaagc ttgcttcctt gtccttggtt ataccatgat ataggcaaat
     7981 cacttaatct taaaccatca ccaaatcctc tctatcaaca atggattgaa acttatatta
     8041 cggatgagtt agagcaacag atcagagagg agggagcact ggtcaatcag ctctatcgag
     8101 aaagtgacga gacagacaag caaaaaatgc tagatgcctt ctacatcagt gttcatatgg
     8161 aagccaagtt ttgggaaatg gcctaccaac accagacatg gaagagcgat ttacagtctt
     8221 tagaaaaagg agaagaatag aagcatgaga aagcaccaat tacaagttca caaattaacc
     8281 attttatcta tgatgattgc ccttgatgta gtccttacac ctatctttcg aattgaggga
     8341 atggcaccga tgtccagtgt agtcaatatt ctagcgggaa tcatgatggg acctgtttat
     8401 gccttggcca tggctacagt cacagccttt atccgtatga cgactcaagg gattccgcct
     8461 ttagctctca caggagcgac ttttggagcc cttctggcag gtctctttta taagtacggt
     8521 cgaaaatttc actattctgc tctaggagag attttgggaa caggtattat tggttctatt
     8581 gtttcctatc ctgttatggt gctctttaca ggatcagctg ctaagcttag ctggtttatc
     8641 tacacgcctc gatttttcgg agcaaccttg attggtacag cgatttcctt tattgccttt
     8701 cgatttttaa tcaagcagga attctttaaa aaagtgcagg gatatttctt tagtgaaagg
     8761 atagactgat gcaggaattt acaaatccct ttcctataga ctctagttcc ctcattcact
     8821 gtatgaccaa tgagatttct tgtgagatgc tggcaaatgg gattttggct ctgggatgca
     8881 aacctgtcat ggcagatgat ccccgtgagg ttcttgattt tactaagcaa agtcaggctc
     8941 tcttcatcaa tttggggcat ttgtcagctg agaaggagaa agcaatccgt atagcagctt
     9001 cttatgcagc tcaagtttgt ctcccaatgg tagtagatgc ggttggcgta acgacttcat
     9061 ccattcgtaa gagcttagtt aaagaccttt tagactatag acctacggtc cttaaaggaa
     9121 acatgtcaga aattcgaagt cttgttggat taaagcacca cggcgttggg gtcgatgcga
     9181 gtgctaaaga tcaagaaacg gaggatttgc ttcaagtctt gaaagactgg tgtcagacct
     9241 atcctggtat gtcattctta gttactggcc ccaaggacct catcgtttcg gagaatcaag
     9301 ttgctgtact ggagaatggc tgtactgaat tagactggat aacagggaca ggagatttgg
     9361 ttggagcctt aacagccgtt tttctcagcc aaggaaagac tggttttgaa gcttcttgct
     9421 tagcagtctc ttatctcaat atcgctgctg agaaaatagt tgttcaagga atgggattgg
     9481 aagaatttcg ttaccaagta ctcaatcagc tttcgctcct aagaagagat gaaaattggc
     9541 tagataccat caaaggagag gcttatgaat agagaagcac ttagactata tctggtaacc
     9601 aatcgctatc aagattccgt ggaaagcttt cttgcaaaag ttgagacggc ctgccgttca
     9661 ggggttacca tagtccaatt gcgagaaaaa aatctcacaa ccaatcaata ttatcaactg
     9721 gcaaaacaag tcaaggaaat aacagatgct tatcaggtac ccttgataat cgatgatcgg
     9781 ttggatgttt gtcttgcggt tgatgctgct ggtctgcata ttggagatga cgaactccca
     9841 gtttcggttg cccgacaagt cttgggtcct gaaaaaatcc tcggtgtcac cgctaaaacg
     9901 gttaaaagag ctctggaagc ggagaaatca ggtgcagatt acttggggac aggagccatt
     9961 tttccgacaa ccaccaagga aaatgcaccc atcaccctga tttcaacctt gaaaacaatt
    10021 tgccaaacgg ttgccattcc aatagttgct attggcggct tgacttcgga gaatattgat
    10081 cagcttatgg gcactggcat agctggtgta gctgttgtac gtgatttgat gcaagcagaa
    10141 gatattgagg caaaaacgca agccttttta acaaagttgc atgacattct ttcctaatta
    10201 atactcaatg aaaatcaaag agtaaactag aaagctagtc gcaggttgct caaagtactg
    10261 ccttgaggtt ttagataaga ctgacgaagt cagctcaaaa cagtgttttg aagttgcaga
    10321 tggaagctgg cgtagtttga agagattttc gaagagtata aaaactctct aattccctta
    10381 aagtgggaac tagagagttt ttttcttaat ctttaaaagt tgtatggttg actggaccag
    10441 aaccatgacc gagttgaggg gcatcttgaa tagcttttgt gataaaggcc ttggccttat
    10501 caactgcctg gtaaagactc ttgcccttgg ctagttcagc agtaatcact gcagcaaagg
    10561 tacatccagt accatgggtg tgacaggttt gaattcgtgg gctttcccag acaaattgtt
    10621 cattcttggt aaagaggaaa tctttagcac cacctttgag atgtccgcct ttgataacca
    10681 cagactgagg accaaattct tttaaaatca ggcgaccagc acgctgcatg tcttcggggt
    10741 catggattga aaaaccaaca atctcttctg cttcaggaag atttggcgta ataatagttg
    10801 ctagaggtag taagtttgtt ttgagatagt ctctagcatt tgagtcaatc aaggcatctc
    10861 cacttgtagc aaccataaca ggatcaagga catagggaca atccagtttt ttaagatagg
    10921 gttggatgat ttccatgatt tcagtagtag ccaacattcc agtttttaca gcctgaggtg
    10981 gaatatcaga aaagacactc tccaattggg ctttcaacat ttgaggagaa acgtgctcga
    11041 ttagctgaac acctctggta ttttgagcga caagactggt tacaacagcc attccataga
    11101 catctctcgc ttggaatgac tttaaatctg ccataatgcc agcaccacca ctagggtcag
    11161 tccctgcaat ggtcaaagca acgggtaaat aagtcatcta aaacctccca accaactgaa
    11221 gtttgtattc ttaagaacaa gctagtctgt tttagaaagg caatagaaga ctgctagtcc
    11281 ccattatcat ttccacttcc atcagctagc attacctaga ttgagtcaga gggatctaac
    11341 agtcgttaat ctcagcttta cgcaccccta gtggttgttt tcttttttct ttagtatagc
    11401 atatttttat tgtttatata gtaatatttg actgcaaatc gtttttcaaa tgattaaaat
    11461 tctatttttc gaagaaaata ttatttctat aattgacaaa tgtagatttt gggagtatac
    11521 tgttgagtgt aattgacaaa tgtagatttt ggaggtatgg taatgcagat ttcagatgca
    11581 gaatggcagg tcatgaagat tatttggatg cagggggagc agaccagtac agatttaatt
    11641 agggttttgg cagagcggtt tgactggtcc aagtccacgg ttcagacact tttggctcgt
    11701 ctagttgaga aagagtgttt gactcggaaa aaagaaggca agttctttgt ttattcagcg
    11761 cttttaactc tagaccaaag tcgggattta cttgtccaag atatcaaaga caaggtttgt
    11821 tcccgtagga ttaggaattt gttggctgac ttgattgtag aatgtgaatt tactcagact
    11881 gacttggaag acttggaagc tgtgatttca gagaagaaat caagtgctgt aacagaagta
    11941 agatgtaatt gtatgtaaag gagacgccat gttaaatagt attgtaacca ttatttgtat
    12001 tgcccttatc gcgtttatct tgttttggtt tttcaaaaag cctgaaaaat ctggacaaaa
    12061 agcccagcaa aaaaacggat accaagagat tcgagtggaa gtcatgggag gctatactcc
    12121 tgagttgatt gtcctcaaga aatcagtgcc agcccgcatt gtctttgacc gcaaggatcc
    12181 ttcaccatgt ctggatcaaa ttgtttttcc agattttggt gtacatgcga acctgccaat
    12241 gggggaagag tatgtagtgg aaatcatgcc tgaacaggct ggagagtttg gctttgcttg
    12301 tggtatgaac atgatgcacg gcaagatgat tgtagagtag gtggagacta tgacagaaat
    12361 tgtgaaagca agcttagaaa atggcattca aaaaatccgt atccgagctg aaaaaggcta
    12421 tcatccagcc catatccagc ttcaaaaggg aattccagct gagattacct ttcatcgtgc
    12481 tactccttca aactgttata aggaaattct gtttgaagaa gaaggtatct tggaaccaat
    12541 cggcgtagat gaggagaaag tcattcgttt tacgcctcaa gaattagggc gacatgaatt
    12601 ttcttgtggc atgaagatgc aaaagggaag ctatacagtc gttgagaaga ctcgaaaatc
    12661 tctatctctc ctgcaacgtt tttggattac tagtatcttt actgtgcctc ttgtgattct
    12721 catgattggg atgttgacag gtagcattag tcatcaagtc atgcattggg gaaccttttt
    12781 agcaacaacg cctattatgt tagttgcagg taagccatat atccagagtg cttgggccag
    12841 ttttaaaaag cacaatgcca acatggatac cttggttgcg ctgggaactc tagtggctta
    12901 tttctatagc ctagttgctc tctttgctgg tctccctgtt tacttcgaaa gtgctggatt
    12961 tatcctcttt ttcgttcttt tgggagcagt ttttgaggaa aaaatgagaa aaaatacgtc
    13021 ccaagctgtg gagaaattac tggacttgca agctaaaacc gcagaagtct tgagtgatga
    13081 tagttatgtc caagttcctt tggaacaagt caaggtaggc gacctgattc gagtgcgtcc
    13141 cggtgaaaag attgctgttg atggtgtcgt agtagaaggt gtctctagta ttgacgaatc
    13201 catggtgaca ggtgagagtc tgcctgtgga caagacagtt ggagatactg tcattggctc
    13261 aaccatcaat catagtggaa cgcttgtctt tagagcagaa aaagttggct cagagactgt
    13321 tttggctcag attgtggatt ttgtgaagaa agctcagaca agtcgtgcgc cgattcagga
    13381 cttgacggat aagatttcag ggatttttgt cccagtagtt gtcattttag gaatcatgac
    13441 cttttgggtt tggttcgtct tgctcaggga tagtgtggtt gtgcttggag ctagctttgt
    13501 gtcctctctt ctctacggag tggcggtttt gattatcgcc tgtccttgtg ccttgggact
    13561 tgcaacaccg acagccctta tggtggggac aggacgtagt gccaagatgg gggttctcct
    13621 caaaaatgga actgtcttac aggaaatcca gaaagttcaa actcttgtct ttgataagac
    13681 cgggactttg acggaaggga aacctgtggt aacagatgtc atcggcgacg aagtagaagt
    13741 gtttgggttg gcagcctcct tggaagatgc ttctcaacac ccactggctg aggctatcgt
    13801 taagcgagcg agtgaagctg gacttgagtt tcaaactgtt gaaaattttc agaccttgca
    13861 cgggaaaggt gtttcagggc gaatcaatgg aaaacaagtt ttacttggaa atgctaaaat
    13921 gctggatggc atggatattt ctaatactta tcaagataaa ctagaagaac tagaaaaaga
    13981 agctaagaca gttgtgttct tagctgttga caatgaaatc aaaggcttgc ttgctttgca
    14041 agatattcct aaggaaaatg ctaagctagt catcagtcag ctaaaaaaac gtggtctccg
    14101 aacagtcatg ctgacaggag acaatgctgg tgtggcgcgt gctattgcag atcaaatcgg
    14161 aattgaagag gtcattgcag gcgtcttgcc agaagaaaaa gcccatgaaa tccataaact
    14221 gcaacagtca gggaaagtag cctttgttgg ggacggtatc aatgacgctc ctgcccttag
    14281 tgtagcagat gtggggattg ctatgggagc tggaacagat atcgccatcg aatcagcaga
    14341 tttggtgttg acaaccaata atcttttagg agtggttcgt gcctttgata tgagtaagaa
    14401 aacctttcat cgaattctac tcaatctttt ctgggctttt atctacaatg ttgttggaat
    14461 tccgattgca gcaggagtct tttcaggtgt tggactggct ctcaacccag aattggcagg
    14521 tctagccatg gcctttagtt ctgtatctgt tctgaccagt tcccttctgt taaattttag
    14581 taaaatagac taaaagtaat gactagattt ctttgttata aaacagaaat gacaacactt
    14641 tcaaaactgt attataatag agaatagaga gttttgagca gatttttaga aaagtcagca
    14701 taaatatgat acagtggaat agtaaaaatt tggagaacgt ttccaattct atgtaatcgt
    14761 attctccaag tctaaaaaaa ttgaaggaga gttatcatta tgactcaagg gaaaattact
    14821 gcatctgcag caatgcttaa cgtattgaaa acatggggcg tagatacaat ctacggtatc
    14881 ccatcaggaa cactcagctc attgatggat gctttggctg aagacaaaga tatccgtttc
    14941 ttacaagttc gccacgaaga gacaggtgct cttgcagcgg ttatgcaagc taaattcggc
    15001 ggctcaatcg gggttgcagt tggttcaggt ggtccaggtg cgactcactt gattaacggt
    15061 gtttacgatg cagctatgga taacactcca ttcctagcga tccttggatc acgtccagtt
    15121 aacgaattga acatggatgc tttccaagag cttaaccaaa acccaatgta caacggtatc
    15181 gctgtttaca acaaacgtgt agcttacgct gagcaattgc caaaagtaat tgacgaagcc
    15241 tgccgtgctg cagtttctaa aaaaggtcca gctgttgttg aaattccagt aaacttcggt
    15301 ttccaagaaa tcgatgaaaa ctcatactac ggttcaggtt catacgaacg ctcattcatc
    15361 gctcctgctt tgaacgaagt tgaaatcgac aaagctgttg aaatcttgaa caatgctgaa
    15421 cgcccagtta tctatgctgg atttggtggt gttaaagctg gtgaagtgat tactgaattg
    15481 tcacgtaaaa tcaaagcacc aatcatcaca actggtaaaa actttgaagc tttcgaatgg
    15541 aactatgaag gtttgacagg ttctgcttac cgtgttggtt ggaaaccagc caacgaagtg
    15601 gtctttgaag cagacacagt tcttttcctt ggttcaaact tcccatttgc tgaagtttac
    15661 gaagcattca agaacactga aaaattcatc caagtcgata tcgaccctta caaacttggt
    15721 aaacgtcatg cccttgacgc ttcaatcctt ggtgatgctg gtcaagcagc taaagctatc
    15781 cttgacaaag taaacccagt tgaatcaact ccatggtggc gtgcaaacgt taagaacaac
    15841 caaaactggc gtgattacat gaacaaactc gaaggtaaaa ctgagggtga attgcaattg
    15901 tatcaagttt acaatgcaat caacaaacat gctgatcaag acgctatcta ctcaatcgac
    15961 gtaggtaaca ctactcaaac atctactcgt caccttcaca tgacacctaa gaacatgtgg
    16021 cgtacatctc cactctttgc gacaatgggt attgcccttc ctggtggtat cgctgctaag
    16081 aaagacaatc cagatcgcca agtatggaac atcatgggtg acggagcatt caacatgtgc
    16141 tacccagacg ttatcacaaa cgttcaatac gaccttccag ttatcaacct tgtcttctca
    16201 aatgctgagt acggcttcat caagaacaaa tacgaagata caaacaaaca cttgtttggt
    16261 gtagacttca caaacgctga ctacgctaaa attgcggaag ctcaaggagc tgttggattc
    16321 acagttgacc gtatcgaaga catcgatgca gttgttgcag aagctgttaa attgaacaaa
    16381 gaaggtaaaa ctgttgtcat cgatgctcgc atcactcaac accgtccact tccagtagaa
    16441 gtacttgaat tggatccaaa acttcactca gaagaagcta tcaaagcctt caaggaaaaa
    16501 tacgaagcag aagaactcgt accattccgt ctcttcttgg aagaagaagg attgcaatca
    16561 cgcgcaatta aataattcct ctcgccgaaa atcaaatatg aaacttgtag actttattct
    16621 ttgattttca tagagcagaa ctttaaaaga tcggagcaat ccggtctttt tatggaggag
    16681 agtaaatgaa tttaaatcaa ttagatatta tcgtttcaaa tgttccccaa gtctgtgctg
    16741 acttggagca tatcttggat aaaaaggcag attatgctga tgatggtttt gctcagttta
    16801 cgattggtag tcactgcctt atgttgtcac aaaatcattt ggttcctttg gaaaactttc
    16861 agtcaggaat cattattcat atcgaggttg aggatgtaga ccagaactac aaacggttga
    16921 acgagcttgg tataaaggtt ttacacggac caactgtaac cgattgggga acagagtcct
    16981 tattagttca aggacctgct ggtctagtgc ttgattttta tcgtatgaaa taggtcgcgt
    17041 agtcatttga cgttaacctt agctattttt aaaatagaaa ttgagaatat gaactattga
    17101 aagatcggag caatccggtc tttttatata aagaaattgc atataatact catctgcttt
    17161 caaaaagcat tctagtccat ctccgattaa cgatggactt tatcacctcc ttctccaatc
    17221 cttgtatgac atcttggagt tgattcatga catcttccaa agttcgaaag gctttattct
    17281 taaatccacg tttacgaatc tctttccaca cttggtcaat ggggttcatc tctggtgtgt
    17341 atggaggaat aaatgcaaag ccaatattag tcggaatctt taaggtactt gatttatgcc
    17401 atatagcatt gtctataacg agtaaaaaat aatcatatgg ataagcttgt gaaagctctt
    17461 ctaaaaaggc gttcatccac tcagtattac atctaccagc tattaagaaa aatgattcgc
    17521 ctgtatgggc atcaacagct ccataacaat agcgaaattc tcgtatatag tgactatgga
    17581 catgtggacc tactcctatt ggagaccaac aagatcccag tttactgatt ctaccgaaac
    17641 cagcttcatc ttggtacatc aagcgaacct tatgaaaagg tctactggtt ttaaagcgct
    17701 ttcttgtctt cttgaattga gattttattt ttagatgcga caatggtttg agcgtctgct
    17761 ttcttaggat gttctggacg tggcgtaata tttcgccaac catggcgctt caacagttga
    17821 tagaaggcat cacgtgtgta ggaacgacct aactcctttt tataagcctg aaataaggca
    17881 tcaattgtaa caaattctcc tgcctctgta gccttcaaat ggcgagcaag aaaggctttc
    17941 tcttcctcaa ctgtcatata tgcatggtta cgaccaccac gtgtttcttg aaggagagag
    18001 tcgagtccga actcctcata ttttttacat ttcgccaaat cgttgtttga ttacagtcta
    18061 aaagctctat aatctcttta taagatttgc ccatcagacg aaatagaacg atttgaaggc
    18121 gtttatgata tttagctgta cgagagtctt ttaaaagtgt tttgatggtt tggatttctt
    18181 ctttagtcaa tttcatatca ctattatata atgctttttg attttagttt agtattatcg
    18241 tagaaaatgg actcggtact atggatacac cggatgagaa tggttatgta gcagatgact
    18301 atcggattac ttacttagag gcccacatca aggccatgcg agatgccatt taccaagacg
    18361 gggttgactt gcttggttat acgacttggg gctgtatcga tccggtttca gctggcacag
    18421 gggaaatgaa taagcgctat ggctttatct atgtagatcg agataatgta ggaaacggag
    18481 ttctcaaacg tagcaagaag aagtccttct attggtacaa ggatgtcatt gatagcaatg
    18541 gtgcaagcat cgagtagagc acatttgttt actattttta taaaatcttc tccctgcttt
    18601 ataagatgta aaaaagagtt caaatggaac tctttttttg ctataatgag gggagaaaaa
    18661 tcagacagga gattaagatg tcagaaccat tatttttaca atcagttatg caagaaaaaa
    18721 tctggggtgg taccaagcta cgtgatgagt ttggctacga catcccaagt gaaaaagtcg
    18781 gagaatactg ggctatctca gctcatctaa atggtgtttc taaagttgcc aatggtcgtt
    18841 acgagggaac agatcttgct actttgtatg cggaacaccg tgaattattt ggcaatcgtc
    18901 cagaacctgt atttccactt ttgaccaaga tcctcgatgc caacgactgg ctcagtgtcc
    18961 aagttcaccc agacgatgct tatggactcg agcatgaagg cgaactcgga aaaacagaat
    19021 gctggtacat catcgctgcg gatgaaggtt cagagattat ctacggtcac aatgccaagt
    19081 caaaagaaga actccgccag caaatcgagg acaagaactg ggataccttg cttaccaaag
    19141 tccctgtcaa ggctggagat ttcttctatg taccaagtgg caccatgcat gctatcggta
    19201 ctggcatctt gattcttgaa acccaacagt ctagtgatac cacttaccgt gtctatgact
    19261 ttgaccgtaa ggatgacaaa ggcaacttgc gtgaacttca tcttgaaaaa tccatcgatg
    19321 tcttgaacat tggtgagcca gcaaatagcc gtcctgtaac tgttaaagca gatgatttgc
    19381 gttccactct ccttgtatct aatgatttct tcgcagttta caagtgggaa attactggaa
    19441 aagttgactt tgaaaagaca gctgactaca gcttattgag tgtcttagct ggtcaaggtc
    19501 agctaactgt tgacgggaaa aattatccaa ttcaaaaagg gagacacttt atcctaccaa
    19561 gtgatgttga agcttggact ctggaagggc aaggtttgga attgattgtt agccatccat
    19621 aaaaagaaag ggcctgagtt cactactcaa gtcctttttg attacataaa ttgggcaatg
    19681 aagaccacaa tgatgatgat tggaatgacg aaacgaagaa acgaagaagg aagagccaga
    19741 cttggaacag tccttgtttc catgctcttt catcgagatg gagttcctcc attgcaagag
    19801 cctttttaaa gatatagcct gtaaaaagtg aaaggtagag agctccaaat ggcatgagga
    19861 gattggaagc caagaagtcc atagcgtcaa agaagatctt accaaaaatg tgaacatccg
    19921 ccatgacacc gtaagatagg gctgaaggaa tgccaaagac aaaggtcaaa attcctaaaa
    19981 taacactcca tttggcacgt ttgctgttat cctggttggt gatattgccc acattgatct
    20041 ccagcatcac gacagaagaa gtgacagtcg caaagaggaa gaggacgtag aaaatggttc
    20101 caaaaggcat cttgtcaaag agttgaggta agacgataaa gagcaggggc atcatgactg
    20161 taacccctag tgagagggca aagaaagatt gtcccagagc atagaggaga ccagcgctag
    20221 tcagttttga aaagtctggt ttgaggaagt aaagaacccc ttccatggca tttggcaaac
    20281 tgagagagcg accgatgata acaacaaaga tgataaagag caggggcatc atgactttcg
    20341 aagctctttc aatccctttt tgaaccccac gtgatacaat aaagatattt aataagataa
    20401 aggctgcttg agctactagg gcaatggctg gatttgaaat gattgaagta aataactgag
    20461 cataatcacc cgttccacca agttggaaca atttcccaaa ctcaatacct agatagacta
    20521 gaatccatcc tccgataaca ctgtaaaaag ataagaggat aaagagggca aaggcgccaa
    20581 tccaaccgat aaagttgtac ttgttattct tgcccagttt tccaaaggtt ttgatagcgg
    20641 aaacgccagc actacggcca agggcaaact cagccagcag gagagggaaa ccgattaaaa
    20701 tagtggaaat gagaaagatt agtaaaaagc ctccaccgcc attagcagca gtcatgtagg
    20761 gaaacttcca aacggaacca agcccgatga ccgagccagc agatgctaga ataaagccaa
    20821 gtttcgaccc ccattgtgat ttttctgaca tagttaaact ctgatctcct ttttcaaaat
    20881 aagaaaaagc tacttgagtt gtcaaatagc cttctgtttg attgatagac ttgactatcc
    20941 tattatgttt tctaaggtct gtcaagaaaa ccattttcaa gttttcacac ctttctcaaa
    21001 aacgcttaac tctgacctaa ggggaggggt tatactatca ttgtaaggag gaaatcatgt
    21061 accatataaa agaagctgcg cagctttcag gtgtctctgt caagaccctg ccctgcatca
    21121 ctatgacaag ataggactct tggtcccctt aaagtcggaa aacggctatc gaacctatag
    21181 tcaagaggat ttggaacgcc ttcaggtcat tctttactac aaatatctag gcttttcttt
    21241 agagaaaata gcagagctgt taaaggaaga aaggacagat ttattgcccc atttaactag
    21301 gcagttggac tatctaactc gcgaaaggca acatctggat accttgattt ccaccttgca
    21361 aaaaactatt caagaacaaa aaggagaaag aaaaatgacc attgaggaaa aattcacggg
    21421 atttagctat caagacaatc aaaaatacca ccaagaagcg gtagagaaat atggtcaaga
    21481 agtcatggga caagcgcttg aacgccaaaa aggtcacgaa aacgaggcta cggccgcctt
    21541 taaccaagtc tttcaaactt tggcacaaaa tcttcaagct ggtttacctg caacagcaac
    21601 cgaaaaccaa gagcaagcag ccaagctctt gcaagccatt cgcacttatg gatttgactg
    21661 ctctattgag gtattcggtc atatcggtaa aggttacgtc tacaacccag agtttaagga
    21721 aaacattgac aagtttggtt ctggaacagc ccagtacacg tcagatgcca ttgcggctta
    21781 cgttcagaca aatgcagaaa aaataggcta ggaatttcct agcctatttt ttacttcaaa
    21841 tcataaagcc agtcgtcacc gtttttgtag taaaagaatt cactgagatc ttcttctaga
    21901 aacacacgaa gcatatcaga catatcatcg gttgcaagtt ttagatgaga aagattttca
    21961 aagtcctccc actaaacttt cccttcgtct gaagactgga gttcaccagt aaagtgttct
    22021 gtcttgtaaa aaaggacgac ataacgataa tccttgtcgt cataccagtt tttgatacca
    22081 cagagttggg gtttggaaat gatcagacca gtttcttctt tcacttcacg aatgacagca
    22141 tcgacaaagg attcgccacg ttcaacatga ccaccaggaa aagtaatgcc agaccagtcg
    22201 ggactaactc ggtcttggac caggacctta tctccgtttt taatcataca catgttaaca
    22261 aattcgactg cctctcttct gttcattctt cacaaccttt aatctttaat cataatgcag
    22321 acttcccgcc acccagccgg tacagagggc agaagtgatg ttaaagccac ccgtgtgggc
    22381 attgatatcc ataacttcgc ctgcaaagtg gaggccaggt accagcttac tttcaagggt
    22441 tttaggattg atttccttga gactgactcc acccttggta acaaaggact ttgcaaggga
    22501 catttttcca gttacaggaa ttttaagttc tttaatggac tggacaagtt gttctcgttc
    22561 cttttcagtc agctgtttga ctttttcagg atatccttgt acaaaaaatt cggccaagcg
    22621 ttctggtaac aaggttttta aagcgttttt caaggatttt tcccgatttt cttctagaaa
    22681 tgtaaccaag tccttctcag aaagttgagg caaaacatcg agtgagagaa cctccccacc
    22741 tttgacaaag ctagacatgc gtagggcagc aggacctgac aaaccaaagt gggtaaagag
    22801 taaatcatga gtgatgacat gcttaccata acttagggtc acatcgtcca aagaaatccc
    22861 ttgtaaggct ttatgtggaa aatctgttaa taaaggactt tcagcagcct caagctcggt
    22921 gatggtatgc ttaaaatggc gagcaatctc gtgaccaaaa ccagtcgaac cagtcgaagg
    22981 ataagactta ccacctgttg tgacaatgag tttctcacaa gtgaaggttt gatccgctga
    23041 cttaaggaca aactggtcat ctactttttt aacagaaacg atttctattt gagtagcaac
    23101 ttgaccacct agttcagtga ttttcttttc caaagcttcg ataatagtcc gagacttgtc
    23161 actggctgga aagacgcgtc cgtggtcttc gaccttaagt ttaacaccat tttctgtaaa
    23221 aaagttgatg atgtcatgat tatcgaactg ggagaaaaca ctgtaaagaa agcgtccgtt
    23281 tccaggaatt ccagctagca ggttgtctaa gctaccattg ttggtcacat tgcaacgtcc
    23341 cccaccagtc ccagctaatt tttttccaag tttccgattt ttttcgatga ggagggtttt
    23401 ctgtccataa aagctactgg aaatcgtagc catcatacca gcaggtcccc caccgatgac
    23461 aatagtatca aaatgtttca tagctctatt gtaccacaaa aaaacaagag atgatggtca
    23521 cctcttgtca agaatgcaat taatcaattt catagcccat cagcaaaccg ccctcttctg
    23581 catagaaact gcagagacca gaggttggta gaattttaat atccgcttgt gggaaggttt
    23641 cacggattcg ctctgagagc tgttgacaac atttttcgtt attgcgttgg gccatgacaa
    23701 tacggccacc agcatatcca gcttttacta actcatcata ggcagcttga actgatttct
    23761 ttgatcccct tgctttttgt agcaattcga gagttccagt ttcactagct tttccgacca
    23821 tacgaatgtt gagaaggcca acgaccgtac cgataagctt gctcaaacgg ccgttcttca
    23881 ccaagttatc gactttggct aggacaaaga gcaacttagt tttttcttga taggcggtga
    23941 tagcttcaac cacttcttca aaagacaagc cctggtcaat caagtcattc aatttttcta
    24001 cgagtaggtc aacttcacca ccagcagata aactatcaat cacatgaatc ttagtgtcag
    24061 gatggtcttc cagataaata ttctttgcta gttgagcact attgtgactg ccagaaaggg
    24121 tacctgtgat ggttactagg aaaatgtttt tggcaccttc aaatgctcgc aaatagtcat
    24181 ctgggcttgg acaagccgat tttgaagctt ctgcagttgc atacatggtt tccatcattt
    24241 ggtcaatatc gagactggcg tcatcaacaa agacctgatc agctacttga atggttaagg
    24301 ggacacttac aaaggttgtg ttaatagctg gtgttggcag ttgacgataa tcacaaccag
    24361 agtcagcaat aatcttccaa gtcatagaaa ttctccatct ttgtcagtta tacattgaca
    24421 aaggttctgt ctttttttac aattatatca tgaaaaccct tgaaacaaaa gcatcatccg
    24481 tctgttgtga caagtagaaa gaaaatgtta tgtctgaacg tagaatctct gaaaagtctc
    24541 ttgaaaatct cagaaaatca aaccaagaat ccaatttatt aaccagagaa gccattgaaa
    24601 cagccctctt gcaactcttg gaaaaaaagg aactgaccaa gattagtatt tctgaattgg
    24661 tcaaacgtgc aggtgtttcg cgtgcggcct tttatcgcaa ttatgactcc aaagaggaaa
    24721 ttttagagag cgtctttaaa cgaactgtcc acaatattat ggaacagctg catcattacg
    24781 atttaaagac agacctttat ttggtttggg ttcacctttt ccgggaggcc agaaaggaag
    24841 ctagagtgat tcaattggcc ttggattacc atctggaaaa aatctttgtc caagccatgc
    24901 aggaatttct agaaaaatac catgggaaat caaaaggtgt cagctcttat cttcattcct
    24961 tctggagctc agccatcgtc tctgtccttc taaaatggat caaggatggc atgaaggtac
    25021 cagctgaaaa gattgcagat ttaggtttac cattttttaa aaaatagaga aaaaggagaa
    25081 aagagatgac tgaaaaaaga ctggcctggg atgagtattt tgcagcccaa gccctactaa
    25141 ttgcgaatcg ttccacttgt aaacgtgcta aagtgggcgc gattctggta aaagataata
    25201 aggttatttc cactggttac aatggttcgg tgtcagggac tgagcattgt attgatcacg
    25261 aatgtttggt cattgaaggc cactgtgttc gcacccttca cgctgaggtc aatgctatcc
    25321 ttcaaggtgc tgagcgtggt gttcccaaag gctttacagc ctatgtaacc cattttcctt
    25381 gtctcaactg tacaaaacaa ttgcttcagg tcggctgcaa gcgtgtggtt tatatcaacc
    25441 agtaccgaat ggacgactac gcccaatacc tttatcaaga aaaagggaca gaattgaccc
    25501 atttaccact tgagacagta cagacagctc ttaaagaggc tgatctaatg taaaaattat
    25561 caaaaataaa tggtttagaa agatttttaa accgtttttt ggtataataa gaagaataaa
    25621 ttgaaagaag gaattccaaa aatgggaaaa attgaagtta ttaatcaccc actgattcaa
    25681 cacaaattgt caatcttgcg tcgtacagat acttctacaa aagcttttcg tgagctagta
    25741 gatgagattg caatgttgat ggggtatgaa gtacttcgtg atcttccact agaagatgtg
    25801 gaaatcgaaa caccaattac aaaaacagtt caaaaacaat tggcaggtaa gaaattggcc
    25861 atcgtcccaa tcttgcgtgc aggtatcggg atggttgatg gtctcttgag cttggttcca
    25921 gctgctaaag ttggccacat cggtatgtac cgtgatgaag aaacacttca accagttgaa
    25981 tacttggtga aattgcctga ggacattgac caacgtcaaa tttttgtagt agacccaatg
    26041 ttggcaacag gtggctcagc aatcttggct gttgattctc ttaaaaaacg tggcgcatca
    26101 aatatcaaat ttgtctgcct tgtatctgct ccagagggtg taaaagccct tcaagaagct
    26161 catccagatg tagaaatctt tacagcagcc ttggatgaac gtttgaacga acacggttat
    26221 atcgttccag gtcttggaga tgctggagac cgcttgttcg gtacaaaata agatcgaaaa
    26281 gaagaatgac ttggaaaagt atttccagtc acgaaaggag gttgggtttt tgtttctgtc
    26341 taatgaaagc agagcaaaaa tttgaccttt tttgaccaag atattataat agtcttatct
    26401 tcagtcattt gaccaacaaa attaaaactc aaaaggagaa atgaatgatt cctgtagtta
    26461 ttgaacaaac aagccgtgga gaacgttctt acgatattta ctcacgtctt ctcaaagacc
    26521 gcatcattat gctgacaggt ccggttgaag acaatatggc taactctgtt attgcccaat
    26581 tgcttttctt ggatgcccaa gatagtacaa aagatattta cctttatgtc aatacaccag
    26641 gtggttctgt ttcagctggt ttggcaatcg tagataccat gaactttatc aaggcagatg
    26701 tccaaaccat tgttatggga atggctgcat ctatggggac tgtcatcgca tcaagtgggg
    26761 caaaaggcaa acgtttcatg cttccaaatg ctgaatacat gattcaccaa ccaatgggcg
    26821 gtacaggtgg tggtacccaa caaactgata tggctatcgc tgcagaacac ttgctcaaaa
    26881 ctcgtaatac cttggaaaaa atcttggctg aaaattcagg tcagtcaatg gaaaaagtcc
    26941 atgcagatgc agaacgtgat aactggatga gcgcccagga aacacttgaa tatggcttta
    27001 ttgatgaaat tatggccaac aattcattga actaatgatg atagaaggca aactcgactg
    27061 ggtttgcttt ttttggtata atagggagag atttcttaga aagaggattt atcatgtttg
    27121 aaaaagtcaa tcgctctggc ttgattatct atctttacta taatcgtgat gccaaaaaac
    27181 tgcaggatta tggagatatt acctatcatt ccaagaaaca tcgttactta caactctatg
    27241 ttccaactca agaagtggag caattggtcg gacgcttgag caaggaaaaa tttattaaaa
    27301 aagttagggt ttgtcatatc caagagttgg aaacaccctt tgtgggcaat ctttatcgat
    27361 aggaaaacgt tatcatcgaa aaaagctcaa ggaaaacatt gacaattttc tgataattcg
    27421 gtatattctt aacagactat ttaagaaata aggagacaaa aagatgaaga aaaaatttgc
    27481 cctatcgttt gtggcgcttg caagtgtagc acttcttgca gcctgtggag aagtgaagtc
    27541 tggagcagtc aacactgctg gtaactcagt agaggaaaag acaattaaaa tcgggtttaa
    27601 ctttgaagaa tcaggttctt tagctgcata cggaacagct gaacaaaaag gtgcccaatt
    27661 ggctgttgat gaaatcaatg ccgcaggtgg tatcgatgga aaacaaatcg aagtagtcga
    27721 taaagataat aagtctgaaa cagctgaggc tgcttcagtt acaactaacc ttgtaaccca
    27781 atctaaagta tcagcagtcg taggacctgc gacatctggt gcgactgcag ctgcggtagc
    27841 gaacgctaca aaagcaggtg ttccattgat ctcaccaagt gcgactcaag atggattgac
    27901 taaaggtcaa gattacctct ttattggaac tttccaagat agcttccaag gaaaaattat
    27961 ctcaaactat gtttctgaaa aattaaatgc taagaaagtt gttctttaca ctgacaatgc
    28021 cagtgactat gctaaaggga ttgccaaatc tttccgcgag tcatacaagg gtgaaatcgt
    28081 tgcagatgaa actttcgtag caggtgacac agacttccaa gcagccctta caaaaatgaa
    28141 agggaaagac tttgatgcta tcgttgttcc tggttactat aatgaggctg gtaagattgt
    28201 aaaccaagcg cgtggcatgg gaattgacaa accaatcgtt ggtggtgatg gattcaacgg
    28261 tgaggagttt gtacaacaag caactgctga aaaagcatca aacatctact ttatctcagg
    28321 cttctcaact actgtagaag tttcagctaa agctaaagcc ttccttgacg cttaccgtgc
    28381 taagtacaat gaagagcctt caacatttgc agccttggct tatgattcag ttcaccttgt
    28441 agcaaacgca gcaaaaggtg ctaaaaattc aggtgaaatc aaggataacc ttgctaaaac
    28501 aaaagatttt gaaggtgtaa ctggtcaaac aagcttcgat gcagaccaca acacagtcaa
    28561 aactgcttac atgatgacca tgaacaatgg taaagttgaa gcagcagaag ttgtaaaacc
    28621 ataatagaaa aatgttgaaa tagggaatga gcctttgact cactccctgt ttcgatattt
    28681 aatactcttc gaaaatctct tcaaactgcg tcaacgtcgc cttggattat atatgtgact
    28741 gacttcgtca gtcttatcta caacctcaaa gcagtgcttt gagcaacctg cggctagttt
    28801 cctagtttgc tctttgattt tcattgagta taagaaccta tcaaaaagtg agggaaaccc
    28861 ctcggaatta taaatagaaa gagtgaatct tatgctccaa caactcgtaa atggtttgat
    28921 tctaggtagt gtttacgcgc tgttagccct aggatatacc atggtttacg gaattatcaa
    28981 gctcatcaac ttcgcccatg gtgatattta tatgatggga gcctttatcg gttatttctt
    29041 gatcaattct ttccaaatga atttctttgt agcgcttatt gtagctatgc tagcgacagc
    29101 tattcttggt gtcgtgattg agtttcttgc ttaccgacct ttgcgccact ctactcgtat
    29161 tgctgttttg attacggcta ttggggtttc tttcctattg gagtatggaa tggtctatct
    29221 ggttggtgcc aatacccgtg ccttccctca agcgattcaa acagttcgat atgatttggg
    29281 accaattagc ttaacaaatg tgcagttaat gattttgggc atttccttga ttttgatgat
    29341 tttgttacaa gtcattgtcc aaaagactaa gatggggaaa gccatgcgtg cagtatcagt
    29401 agatagcgac gcggcgcaat tgatggggat caatgtaaac cgtacgatta gctttacctt
    29461 cgctttgggt tctgctcttg cgggtgcggc tggtgttctg attgctcttt attataactc
    29521 tcttgagcct ttgatggggg ttactccagg tcttaaatct ttcgttgccg cagtacttgg
    29581 tggtatcgga attattcctg gtgctgctct tggtggcttt gtgattggtc tattggaaac
    29641 ctttgcgaca gcctttggga tgtcagattt tcgtgatgcc attgtttatg gaatcttgtt
    29701 gttgatcttg attgtccgcc cagctggtat ccttggtaag aatgtgaaag agaaggtgta
    29761 aacgatgaag gaaaatttaa aagttaatat tctatggtta ctccttttgt tagctggcta
    29821 tagcttgatt agtgtactgg tttcagtcgg agtacttaat ctattctatg tacagatttt
    29881 acaacaaatt ggaattaata ttattttggc tgttggtctc aacttaatcg ttggtttttc
    29941 aggacaattt tcacttggtc atgctggttt catggcgatt ggtgcctatg cagcagctat
    30001 tattggttct aaatcaccaa cctacggtgc cttctttgga gctatgcttg taggggcttt
    30061 gctttcagga gcagttgcct tacttgtcgg cattccaacc ttgcgcttga agggggacta
    30121 tcttgcggta gcaactctag gtgtttctga aattatccgt atctttatca tcaatggtgg
    30181 aagccttaca aatggtgcgg caggtatctt agggattcct aactttacaa cttggcaaat
    30241 ggtttacttc tttgtcgtga ttacaaccat tgcaaccttg aacttcttgc gtagcccaat
    30301 tggtcgttca accctctctg ttcgtgaaga tgaaatcgct gctgagtcag ttggggttaa
    30361 tacgactaaa attaaaatca tcgcttttgt ctttggtgcc attactgcaa gtattgctgg
    30421 gtcacttcag gcaggattta tcgggtctgt tgtaccgaaa gattacacct tcatcaactc
    30481 aatcaacgtt ttgattattg ttgtatttgg tggactcggt tccattacag gtgcgattgt
    30541 ttcggctatt gttctgggaa ttttgaatat gcttctccaa gatgttgcta gtgtgcgtat
    30601 gattatttac gctttggcct tggtattggt aatgattttc agaccaggtg gactccttgg
    30661 aacgtgggaa ctgagcctat cacgtttctt taaaaaatct aagaaggagg aacaaaacta
    30721 atggcattac ttgaagtaaa acagttaacc aaacattttg gtggtctaac agctgttgga
    30781 gatgtgactc ttgaattgaa cgaaggggaa ctggttggat taatcggtcc aaacggagct
    30841 gggaaaacca cccttttcaa ccttttgacc ggtgtttatg aaccaagcga gggaacagta
    30901 accctagatg gtcacctttt gaatgggaaa tcaccttata agattgcctc tttgggactt
    30961 ggacgtactt tccaaaatat ccgtcttttt aaagatttaa cagttttaga caatgttttg
    31021 attgcttttg gaaaccatca caaacagcat gtttttacta gtttcttacg cttaccagct
    31081 ttttacaaga gtgaaaaaga attaaaggct aaagctttgg aattgttgaa aatctttgat
    31141 ttagatggtg atgcagagac tcttgctaaa aatctttcct acggacaaca acgtcgtttg
    31201 gaaattgttc gtgcccttgc tacggaacct aaaattctct tcttagatga accagcagca
    31261 ggtatgaacc cacaggaaac agccgaattg actgagttaa ttcgtcgtat caaagatgaa
    31321 tttaagatta caatcatgtt gattgaacac gatatgaatc tggtcatgga agtaacagaa
    31381 cgtatctacg tacttgaata tggccgttta attgctcaag gaactccaga cgaaattaag
    31441 accaataaac gcgttatcga agcttatcta ggaggtgaag cctaatgtct atgttaaaag
    31501 ttgaaaatct ttctgtgcat tacggtatga tccaagcagt ccgtgatgta agctttgaag
    31561 ttaatgaagg agaagttgtt tcccttatcg gtgccaacgg tgcaggtaag acaactattc
    31621 ttcgcacctt gtcaggtttg gttcgaccaa gttcaggaaa gattgaattt ttaggtcaag
    31681 aaatccaaaa aatgccagct cagaaaattg tggcaggtgg tctttcacaa gttccagaag
    31741 gacgccacgt ctttcctggc ttgactgtta tggaaaatct tgaaatggga gctttcttaa
    31801 agaaaaatcg tgaagaaaat caagctaact tgaagaaggt tttctcacgc tttcctcgtc
    31861 ttgaagaacg taagaaccaa gatgcagcta ctctttcagg aggggaacaa caaatgcttg
    31921 ccatgggacg cgctcttatg tcaacaccaa aacttcttct tttagatgaa ccatcaatgg
    31981 gacttgcccc aatcttcatc caagagattt ttgatatcat tcaagatatt cagaagcaag
    32041 gaacaaccgt cctcttgatt gaacaaaatg ccaataaagc acttgcaatc tctaaccgag
    32101 gatatgtact ggaaacaggg aaaatcgtcc tatcaggaac aggaaaagaa ctcgcctcat
    32161 cagaagaagt cagaaaagca tatctaggtg gctaaaacaa tccagtggat tgttttagtc
    32221 ggcagatgaa gattacgaag taatcatcat tatagtctgg gagactagtt taggttgcag
    32281 ataaagattg cgaagcaatc atcaaatcca gaggattgtt ttagccggca gatggagatt
    32341 acgaagtaat catcaatata gtccggggga cctttttagt cggtggatag agattgcaaa
    32401 caaatatgca tctacattga aagcttaatt tctaataatt gaaaaaatcg aatgaaaaat
    32461 ttcttacctt cattcacaga gctctatttc agagctcttt ttgctagctt attcatactt
    32521 ttttgaattt cgaaaaagaa atgtaagcgt ttgatagatt tacaaaaaga ttgtataatg
    32581 gggataagaa tagaaaagga gaagtctcat ggcagttaaa gattttatga cccgcaaggt
    32641 agtttatatt agtccagata caacagtatc tcatgcagca gatttgatga gagagcaagg
    32701 tttgcaccgt ctgcctgtta tcgaaaatga tcaattagtt ggtttggtga ctgagggaac
    32761 cattgcacaa gcaagtccat ctaaagcaac aagtctttct atctatgaga tgaattatct
    32821 tctgaataag acaaaagtaa aagatgtcat gattcgcgat gttgtcactg tctcaggcta
    32881 tgctagtcta gaagatgcaa cttatctgat gttgaaaaat aagattggta ttctccctgt
    32941 cgtagataac tatcaagtat acggagttat tactgaccgt gatgttttcc aagcctttct
    33001 tgaaattgca ggttatggcg aagaagggat tcgtgtacgc tttgttacag aagatgaagt
    33061 tggtgttctt ggaaaaattg tttctttgat tgtagaagaa aatttgaata tctcccatac
    33121 agtcaatatt ccgcgtaagg atggtaaggt gattatcgaa gtgcaaatcg atgaatcaat
    33181 tgatttacca gccttgaaag aaaaatttga agcaaatggt attcaagtgg aagaaatcgc
    33241 tcgcacttca gcaaaagtct tgtaagaagg gaagtccaaa ggcttctttt ttcatgaaaa
    33301 ggggattaga gcaaaagatg gaaagaaatg ataaaatatg ctataatgaa ataatgtaaa
    33361 aaaggagtat ttatggacat ttcagtaatt cgtcagaaaa ttgacgcaaa tcgtgaaaaa
    33421 ttagcttctt tcagggggtc tctttgacct cgaagggcta gaggaagaga ttgccatctt
    33481 ggaaaacaag atgacagaac ctgatttttg gaacgataat attgcggccc aaaaaacgtc
    33541 gcaagaattg aatgaattaa aaaacactta caataccttc cataagatgg aagagttgca
    33601 ggatgaagtc gaaattttat tggatttttt ggctgaagac gagtcagtgc atgatgaact
    33661 ggtagcgcag ttagccgaac ttgataagat aatgaccagc tacgagatga ctctactctt
    33721 gtcagaacct tatgaccaca acaatgccat cttggaaatc catccaggtt ctggtggtac
    33781 tgaggcgcag gactggggtg atatgttgct tcgtatgtat actcgttatg gtaatgctaa
    33841 aggctttaaa gtggaagtgt tggattacca agcaggtgat gaggctggta ttaagttggt
    33901 aactttatca tttgaagggc ctaatgccta tggtctcctc aagtcagaaa tgggtgttca
    33961 ccgcttagtg cgaatctcac catttgactc tgccaaacgt cgccatacct ctttcacatc
    34021 tgtagaagtg atgccagaat tggatgatac tattgaagtg gaaatccgtg aagatgatat
    34081 caagatggat accttccgtt caggtggtgc cggtggacaa aacgtcaata aggtttcaac
    34141 aggtgtacgt ttaacccaca ttccaactgg aattgttgtc caatcaacag tggatcgtac
    34201 ccagtatgga aatagagatc gtgccatgaa gatgttgcag gctaagctct atcaaatgga
    34261 gcaagataag aaggctgcgg aggtagattc tctcaaaggt gagaaaaagg agatcacttg
    34321 gggaagccaa atccgttctt atgtcttcac gccttatact atggtaaaag atcaccgaac
    34381 tagctttgag gttgctcagg tagataaggt tatggatggg gacctagatg gttttatcga
    34441 tgcttatctc aagtggcgaa ttagctaaga tagaaaggaa ctcacatgtc aattattgaa
    34501 atgagagatg tcgttaaaaa atacgacaac ggaacgactg ctctacgcgg tgtttcggtc
    34561 agcgttcaac cgggggaatt tgcttacatc gtaggacctt caggagcagg gaagtcaact
    34621 tttattcgtt ctctgtatcg tgaagtaaaa atcgataaag gaagtctatc agttgctggt
    34681 tttaatctgg ttaagatcaa aaagaaagat gtcccgcttc tacgtcgtag tgttggggtt
    34741 gtcttccaag attataaatt gttaccaaag aaaactgtct atgaaaatat tgcttacgct
    34801 atggaagtaa tcggggaaaa tcgccgtaat atcaaaagac gagtgatgga agttttggac
    34861 ttggttggat tgaagcataa ggttcgttct ttcccaaatg aactctcagg tggggagcaa
    34921 cagcgaattg cgattgcgcg tgcaattgta aataatccca aagtattgat agctgatgag
    34981 ccaacaggaa atctggatcc ggataattca tgggaaatta tgaatctctt ggaacggatt
    35041 aacctacaag ggacaactat tttgatggcg actcataata gccagattgt aaataccttg
    35101 cgccaccgtg tcattgccat tgaaaatggc cgtgtcgttc gtgacgaatc aaaaggagag
    35161 tatggatacg atgattagta gattttttcg ccatttattt gaagccttaa aaagtttgaa
    35221 acgaaatggt tggatgacag tagctgctgt cagttcagtc atgattactt tgaccttggt
    35281 ggcaatattt gcatctgtta ttttcaatac agcgaaacta gctacagata ttgaaaataa
    35341 tgtccgtgta gtagtttata tccgaaagga tgtggaagat aatagtcaga caattgaaaa
    35401 agaaggtcaa actgttacaa ataatgacta ccacaaggta tatgattctt tgaagaacat
    35461 gtctacggtt aaaagtgtta ccttttcaag taaagaagaa caatatgaaa aattaaccga
    35521 gataatggga gataactgga aaatctttga aggagatgcc aatcctctct atgatgccta
    35581 tattgtagag gcaaacactc caaatgatgt aaaaactata gccgaagatg ctaaaaaaat
    35641 tgaaggtgtc tctgaggttc aagatggcgg tgccaataca gaaagacttt tcaagttagc
    35701 ttcatttatc cgtgtttggg gactagggat tgctgctttg ttaattttta tcgcagtttt
    35761 cttgatttca aataccattc gtattaccat tatttcccgc agtcgcgaaa ttcaaatcat
    35821 gcgcttggtc ggagctaaaa acagttatat ccgtggaccg ttcttgttag aaggagcctt
    35881 tatcggttta ttgggagcta tcgcaccatc tgttttggtc tttattgttt atcaaattgt
    35941 ttaccaatct gtcaacaaat cgttggtagg gcaaaatcta tccatgatta gtccagattt
    36001 atttagtccg ttgatgattg ccctactatt tgtgattggg gttttcattg gttcattggg
    36061 atcaggaata tccatgcgcc gattcttgag gatttaggta aaatagctgc ttttatgagg
    36121 agattgtaaa atctcctttt ttgctacaag agtttttgaa aagagatgcg tagaagaaaa
    36181 gagcttccaa agaagtcccc cagagaagac ttcttgatgg ctaatttgaa cttgaaattt
    36241 ggcgcactag aaatttttta gaaaaaagtg taattttttt ataaaagcct ttacaaaaaa
    36301 aattaaagtg gtataattaa atcatagaag gtgcaaacgt tttcgtaaaa cgtttgccta
    36361 aataaaaata aaggagattt gaatgatgaa agatacattc aaaaatgtct tgtctttcga
    36421 attttggcaa aaattcggta aggctttgat ggtagttatc gcggttatgc cggctgctgg
    36481 tttgatgatt tcaatcggta agtctatcgt gatgattaac ccaaccttta caccacttgt
    36541 catcacaggt ggaattcttg agcaaatcgg ttggggggtt atcggtaacc ttcacatttt
    36601 gtttgcccta gccattggag gaagctgggc taaagaacgt gctggtggtg ctttcgccgc
    36661 tggtcttgcc ttcatcttga ttaaccgtat cactggtaca atttttggtg tatcaggcga
    36721 tatgttgaaa aatccagatg ctatggtaac tactttcttt ggtggttcaa tcaaagttgc
    36781 tgattacttt atcagtgttc ttgaagctcc agccttgaac atgggggtat tcgtagggat
    36841 tatctcaggt tttgtagggg caactgctta caacaaatac tacaacttcc gtaaacttcc
    36901 tgatgcactt tcattcttca acgggaaacg tttcgtacca tttgtagtta ttcttcgttc
    36961 agcaatcgct gcaattctac ttgctgcttt ctggccagta gttcaaacag gtatcaataa
    37021 cttcggtatc tggattgcca actcacaaga aactgctcca attcttgcac cattcttgta
    37081 tggtactttg gaacgtttgc tcttgccatt tggtcttcac cacatgttga ctatcccaat
    37141 gaactacaca gctcttggtg gtacttatga cattttaact ggtgcagcta aaggtactca
    37201 agtattcggt caagacccac tatggcttgc atgggtaaca gaccttgtaa accttaaagg
    37261 tactgatgct agtcaatacc aacacttgtt agatacagta catccagctc gtttcaaagt
    37321 tggacaaatg atcggttcat tcggtatctt gatgggtgtg attgttgcta tctaccgtaa
    37381 tgttgatgct gacaagaaac ataaatacaa aggtatgatg attgcaacag ctcttgcaac
    37441 attcttgaca ggggttactg aaccaatcga atacatgttc atgttcatcg caacacctat
    37501 gtatcttgtt tactcacttg ttcaaggtgc tgccttcgct atggctgacg tcgtaaacct
    37561 acgtatgcac tcattcggtt caatcgagtt cttgactcgt acacctattg caatcagtgc
    37621 tggtattggt atggatatcg ttaacttcgt ttgggtaact gttctctttg ctgtaatcat
    37681 gtactttatc gcaaacttca tgattcaaaa attcaactac gcaactccag ggcgcaacgg
    37741 aaactacgaa actgctgaag gttcagaaga aaccagcagc gaagtgaaag ttgcagcagg
    37801 ctctcaagct gtaaacatta tcaaccttct tggtggacgt gtaaacatcg ttgatgttga
    37861 tgcatgtatg actcgtcttc gtgtaactgt taaagatgca gataaagtag gaaatgcaga
    37921 gcaatggaaa gcagaaggag ctatgggtct tgtgatgaaa ggacaagggg ttcaagctat
    37981 ctacggtcca aaagctgaca ttttgaaatc tgatatccaa gatatccttg attcaggtga
    38041 aatcattcct gaaactcttc caagccaaat gactgaagca caacaaaaca ctgttcactt
    38101 caaagatctt actgaggaag tttactcagt agcagacggt caagttgttg ctttggaaca
    38161 agtaaaggat ccagtatttg ctcaaaaaat gatgggtgat ggatttgcag tagaacctgc
    38221 aaatggaaac attgtatctc cagtttcagg tactgtatca agcatcttcc caacaaaaca
    38281 tgcttttggt attgtgacgg aagcaggtct tgaagtattg gttcacattg gtttggacac
    38341 agtaagtctt gaaggtaaac catttacagt tcatgttgct gaaggacaaa aagttgcagc
    38401 aggagatctc cttgtcacag ctgacttgaa tgctatccgt gcagcaggac gtgaaacttc
    38461 aacagtagtt gtcttcacaa atggtgatgc aattaaatca gttaaattag aaaaaacagg
    38521 ttctcttgca gctaaaacag cagttgctaa agtagaattg taatatactt gaggttggaa
    38581 gctgtattcc aacctcttat tttgggagaa aagaatgaaa tttttaacac tcaatactca
    38641 cagttggatg gagaaagaag cagaggaaaa attccagatt ttgcttgaag atattcttga
    38701 aaaggactat gatttgattt gtttccaaga aatcaatcag gagatgacct cgtcagaggt
    38761 ggaggttaat gacctttatc aagctttgcc agcagctgag cctattcacc aagaccatta
    38821 tgttagactc ttggttgaaa agttgttaga gcaagggaaa aattactact ggacctgggc
    38881 ttataaccat atcggctatg accgctacca cgaaggtgtg gctatcttgt ctaaaacacc
    38941 tattgaagcc agagaaattt tggtttcaga tgtggatgat ccaacagact atcatactcg
    39001 ccgtgttgcc ctagctgaaa ctgtagtcga tggcaaggag ctagcagttg ccagtgttca
    39061 tctctcttgg tgggataaag gtttccaaga agaatgggca cgatttgagg ctgtcttgaa
    39121 aaaattgaac aagccacttt tactagctgg agattttaac aacccagcag gtcaggaagg
    39181 ttaccaagct attttagcta gtccattagg cttacaagac gcatttgaag ttgctcaaga
    39241 gaaaagtggt agctatactg ttccgcctga aattgatggc tggaaaggga acactgaacc
    39301 ccttcgaatc gattatgtct ttactaccaa agagttagcg gtggaaaatt tacatgtcgt
    39361 atttgatggt aacaagagtc cacaagtgag tgatcactat ggcttgaatg ctatgttaaa
    39421 ctggaaataa taactgaaaa gaggttggaa ctataaaatt ccagcctttt cttactagag
    39481 aagctactgg aaatagccta aataagtgag actactgtaa tggaataaaa tatggtataa
    39541 ttgataagat agatagaatc gaggatgtta tgtcatttac gaaatttcaa tttaaaaact
    39601 atattagaga agccttgaag gagttaaaat ttacaactcc aacagaggtg caagacaagt
    39661 tgattcctat tgttttggca ggtcgtgacc tagtaggaga atcaaaaaca ggttcaggta
    39721 agactcatac tttcttgtta ccgatttttc agcaattaga tgaagctagc gatagtgtac
    39781 aagcagtgat tactgcaccg agtcgtgagt tggctactca aatttaccaa gtagcgcgtc
    39841 agatttcagc tcactcagat gtcgaagttc gtgtggttaa ttatgtgggt ggtacggata
    39901 aggctcgcca gattgagaaa ttggcaagca atcagcctca tattgttatt ggaacaccag
    39961 gccgtatcta cgacttggtt aaatctggtg atttagctat tcataaagcc aagacatttg
    40021 ttgttgatga agcggatatg accttggata tgggattctt ggaaactgtt gataagattg
    40081 ctggcagtct tccaaaagac ttgcaattca tggtcttctc agcgactatc ccacaaaaac
    40141 tgcaaccatt cttgaaaaaa tacttatcca atcctgttat ggagaaaatt aagaccaaaa
    40201 cggttatttc tgacaccatt gataattggt tgatttcgac caagggacat gataagaatg
    40261 ctcaaattta ccagttgact cagttgatgc agccgtattt ggcaatgatt tttgttaaca
    40321 ctaaaacgcg tgctgatgaa ttgcattcat atctgactgc tcaaggcttg aaggttgcaa
    40381 aaatccatgg cgatattgcc cctcgtgaac gcaagcgaat catgaatcag gtgcaaaatc
    40441 tggattttga gtatattgtc gcaacagatt tagcagcgcg tgggattgac attgaaggtg
    40501 tcagccatgt catcaatgat gccattccgc aagacttatc tttttttgtt caccgtgttg
    40561 gtcgtactgg acgaaatggc ctaccaggta cagctattac cctttatcag ccaagtgatg
    40621 actcggatat ccgtgagttg gagaaattgg gaatcaagtt tagtcctaag atagtcaaag
    40681 atggggaatt tcaagatacc tatgaccgtg atcgtcgtgc caaccgtgag aaaaaacaag
    40741 ataaacttga tatcgaaatg attggtttgg ttaaaaagaa aaagaaaaaa gtcaaaccgg
    40801 gttataagaa gaaaattcaa tgggcggttg atgaaaagcg ccgtaaaacc aagcgtgctg
    40861 aaaatcgcgc tcgcggtcgt gcagagcgta aagctaaacg ccaaacattt taatagaaat
    40921 tgttggagta ctgagctcca acttttttat ttatgagaac gaactatcta aaccgaaaca
    40981 ctacattaaa gactgcaaat tgcgattaaa aatggtataa tgataaagtt atatagtccc
    41041 gataagatgg taggtattta ttacgaagag ttttcctatc agtagtttgc aattcgcaaa
    41101 gaatgacggc ttcgaggtcg ctcgtctttc tacggttgct gccatactgc ggtcacccta
    41161 tgcgccttac tagcttcaga aataaaaaag tatcgttttt atttctgaag ctagtaactc
    41221 ttagataatg gaaattccta tcagtacttt gtaactctat aacaatattt tttaaggggg
    41281 gacattttta tgtcagaacg taaattattc acgtctgaat ctgtatctga ggggcatccg
    41341 gataagattg cagaccaaat ttcagatgcg attttggatg ctattttagc aaaggatcca
    41401 gaggcgcacg ttgctgctga aacagctgta tatactggtt ctgtccacgt ttttggtgaa
    41461 atttctacaa atgcctatgt ggatattaac cgtgtggttc gtgataccat tgcagagatt
    41521 ggttatacca atacagaata tggattttct gctgagacgg tgggagtaca cccatctttg
    41581 gtggaacaat ctcctgacat cgctcaaggt gttaacgaag ccttggaggt tcgtggaaat
    41641 gctgatcaag atccactgga cttgattgga gcaggtgacc aagggctcat gtttggattt
    41701 gcagtagatg aaacagaaga gctcatgcca ttgccaattg cactcagtca taaattggtt
    41761 cgtcgtctgg cagaacttcg taagtctgga gaaattagct atctccgtcc agatgcaaaa
    41821 tcacaagtta cagttgagta cgatgaaaat gaccgtccgg tacgtgtaga tacagtcgtt
    41881 atttctactc agcatgatcc agaggccact aatgaacaaa tccatcaaga tgtgattgac
    41941 aaggtcatca aagaagttat tccatcttct tatcttgatg ataagacaaa attctttatc
    42001 aatccgacag gtcgttttgt aatcggtggt cctcaagggg actcaggttt gactggtcgt
    42061 aagattattg tagatactta tggtggctac tctcgtcatg gtggtggtgc cttctctggt
    42121 aaagatgcga ctaaggtgga tcgttcagcc tcttatgcgg ctcgctatat tgccaagaat
    42181 atcgttgcag cagaccttgc taagaaggca gaagtgcagt tggcctatgc tatcggtgtt
    42241 gcgcaacctg tttctgttcg tatcgatact ttcggtacag gaacagtagc tgaaagtcaa
    42301 cttgaaaaag cggctcgtca aatctttgac cttcgccctg cagggattat ccaaatgctg
    42361 gaccttaagc gtccaattta ccgtcaaaca tcggcttacg gtcacatggg acgtacagat
    42421 attgatcttc catgggaacg tttggataag gtagatgctt tgaaagaagc agtaaaataa
    42481 gattttaaga ggggaacgtc ctctcttttt tatagttttt aactgtactg ggatactgtt
    42541 ctgaaaatcc attttgagaa agtagagatt tacatgtata gtagattgaa actagaatag
    42601 tacacctcaa cttctaaaac attgttagaa atcgatttga ctgtcctgat cgatttctcc
    42661 tgttcttgtt tcattttact atatttcttt aaaaatgata aaggttgaga tttctcctcg
    42721 taatagataa tcatggggat atttcaagcc aaagttttat tcgttatcac ttgactattg
    42781 caaggttttc tagagcaaca gagtcatgga atggactcat ggttgagatt tctccttgtt
    42841 gcttggactt cattcaaaag tctgttaccc aagccttgtt caaacttcca atacactagc
    42901 tgtttccata gcatgacttc tgtactagac tttcttttcc gaataaatag atagaaccac
    42961 agaatctagt aaacctagaa ttaaaattat ggtataatat tagcaataaa agaaatctgg
    43021 aggattagaa tcatggtatc aacgaaaaca caaattgctg gttttgagtt tgacaattgc
    43081 ttgatgaatg cagcaggtgt ggcttgtatg acgatagagg agttagaaga ggtcaaaaac
    43141 tcagcggcag gaacctttgt tactaagaca gcgaccttgg acttccgtca ggggaatcct
    43201 gagccacgct accaagatgt tccacttggt tccatcaact ctatgggctt gccaaataat
    43261 ggcttagact attatttgga ttatctttta gatttgcagg aaaaagagtc gaaccgaact
    43321 ttcttcttat ctctggtcgg catgtctcca gaggaaaccc atactatttt gaaaaaagtc
    43381 caagagagtg attttcgtgg tctgactgag ctaaatcttt cctgtccaaa tgttccaggt
    43441 aaacctcaga ttgcctatga ttttgagaca acagaccgga ttttggcaga agtgtttgct
    43501 tacttcacca aacctcttgg aattaaattg ccaccttatt ttgatattgt tcactttgat
    43561 caagcggcag ctattttcaa caaatatccg ctcaagtttg tcaactgcgt taactctatc
    43621 ggaaacggcc tctatataga agatgaatct gtcgttattc ggcctaagaa tggttttggt
    43681 ggaattggtg gagaatacat caaaccgact gctctagcca atgttcacgc cttttatcaa
    43741 cgtttaaatc ctcaaatcca aattatcgga acaggtggcg ttctgactgg tcgagatgcc
    43801 tttgaacaca tcctctgtgg agcaagtatg gtgcaggtgg gaacgaccct tcacaaagaa
    43861 ggcgtcagtg cttttgaccg cattaccaat gaactgaaag caatcatggt ggaaaaaggc
    43921 tacgagagct tagaagattt ccgtgggaaa ttgcgctata ttgactaaat taaatcgaaa
    43981 aatctgaaga aaggagagac gatgctagcc attgaagaaa gtcagaagtt gactttatca
    44041 aatttaccga gcctgagcct atttacaggg acagatcagg gtcagtttga agtgatgaag
    44101 agtcaagtgt tgaaacagat tgggtatgat tctgctgacc tcaactttgc ctactttgat
    44161 atgaaagaag tagtttacaa ggatgtggaa ctggagttgg tcagccttcc tttctttgcg
    44221 gatgagaaaa tcgtgatatt agattatttt atggatatca cgactgctaa gaaacgcttt
    44281 ttgacagatg atgagcttaa gtcatttgag gaataccttg acaatccttc tccaacaacc
    44341 aagttgataa tctttgcaga aggaaagctg gatagcaaaa gacggttagt caaattactt
    44401 aagcgtgatg ccaaggtctt cgatgcagta gaagtaaaag aacaagaatt gcgccagtat
    44461 ttccaaaagt ggagtcagaa acaaggtctg cagtttacca atcattcttt tgaaaatctc
    44521 ctcatcaagt cggggtttca atttagcgaa atccagaaaa atcttctctt tttacagtcc
    44581 tataaggcga attctgttat cgaggaagag gatattgtta acgcaattcc caagaccttg
    44641 caggacaata tttttgattt aactcagttt attctgacta aaaagatgga tcaggcgcgc
    44701 gatttggtga gagacttgac cttgcaaggg gaagatgaaa tcaaactgat tgcagtcatg
    44761 ctgggacaat ttcggacttt tactcaggtg aagattttgg cggagtctgg ccaaacagaa
    44821 tcgcagattg caagtagttt aggtagttat ctgggacgta acccaaatcc ttatcaaatc
    44881 aagtttgcat taagagattc gagaggactt tctttgagct ttctgaagca agctatttcc
    44941 tatttgattg agacagacta tcagattaag acaggtcttt atgaaaaagg tttccttttt
    45001 gaaaaggcac tcttacagat tgctagtcag gtcaattgac atttgttgaa actacaaccc
    45061 acgtcaggat tatcttgtcg tgggtttctt gctgatttgc ttattttatt agaaagtatg
    45121 tcagtgattt ccttatctat aagcaaaaaa cttgaaaaaa gtgaatgttt gcgttatcat
    45181 tttcatatag aaagaaaaag aggtattaca gatggctatt atcttaccag aacttccata
    45241 tgcatacgac gctttggaac catacatcga tgcggaaaca atgcatttgc accatgacaa
    45301 acaccatcaa acttatgtca acaatgccaa tgcagcttta gaaaaacacc ctgaaatcgg
    45361 tgaagacctt gaagccttgc ttgctgatgt agaatctatc ccagctgata tccgtcaagc
    45421 acttatcaac aatggtggcg gacacttgaa ccacgctctt ttctgggaat tgatgactcc
    45481 cgagaaaaca gctccttcag cagaactagc agcagcaatc gatgcaacat ttggttcatt
    45541 tgaagaattt caagcagcct tcactgcagc agcaacaact cgttttggtt caggttgggc
    45601 atggttggtt gtcaacaaag aagggaaact tgaagtgact tcaacagcaa accaagacac
    45661 accaatctca gaaggtaaaa aaccaatctt gggcttggac gtttgggaac atgcttacta
    45721 cgtgaaatac cgcaacgtgc gtcctgacta catcaaagct ttcttttcag taatcaactg
    45781 gaataaagta gatgaattgt acgcagctgc taaataataa tagttggagg gaagaattgt
    45841 tcttctcttt tttaggttat aagattctgg tctgacaaaa tcgtcagact tttttcattt
    45901 ttatgagaaa cgtgctaact gctagaaatt atggtagaat aaagtattaa gtaatcgtgg
    45961 aaaaaggata tctatgcgaa aagaaattgc acctgaatta tacaactata acaagtttcc
    46021 tggtccggag ttccatttac acggggacaa ggtcgaaacg gaagggatag ctttttcctt
    46081 ggttgaaaat atcaaggatg cctttgatgt gacgactttt aatcagcgtt tttcagaagt
    46141 cttaaccaag tttgattata tcgtggggga ctggagcaac gaacagcttc gcctacgagg
    46201 tttttacaag gatgaccgaa cagaagaaaa acttgaaaaa atcagtcgtt tacaagacta
    46261 ccttttagag tattgtagtt atggttgtgc ctattttgtc ttagaaaatg aagcccctaa
    46321 gcgagcatca tttgacaaga aaatgcgtaa gacggaagaa gaaacacctt ctagaaaagg
    46381 aaagaaaccg actcaaacta aacgaaagtc gaatgcagat aagaaaaata gacgtcgtca
    46441 gaaagaccag cattctcaga aagaggacaa gggacaacgt cattttgtca ttcgtcagaa
    46501 gtgagtagag aataaggaga agaaatgaaa ccctcaattc atagtttggc acatcaaacc
    46561 atgcagaaat gggtattgga gcagggagaa aagaaattcc gtgcagatca aatctgggaa
    46621 tggctctacc gtaaacgtgt gcagtcattt gaagaaatga ccaacctttc caaggatttg
    46681 attgctaagc tcaatgacca gtttgtggtc aatcccttga aacaacgtat tgtgcaagag
    46741 tctgctgatg gtacagtcaa atatctcttt gaattgcctg acggtatgtt aattgagact
    46801 gtactcatgc gtcaacacta tggtttatct gtctgtgtga ccactcaggt cggctgtaat
    46861 atcggttgta ccttctgtgc atctggtttg attaagaagc agcgtgacct caataacggt
    46921 gaaatcgtag cgcaaatcat gctggttcag aaatactttg ctgatgaagg ggttcaggtc
    46981 aatcttgccg tgtctcttca cgcacccaac aatgaacttc gttcaagtat catgaagatt
    47041 aaccgtgcct ttccgattga aaaactcttt gctgctattg aatactacat tgagacaaca
    47101 aaccgtcgtg taacctttga atatatcatg cttaatgaag tcaacgacgg tgtagaacaa
    47161 gccttggaat tggctgaatt gctcaagaac atcaagaaat tgtcttatgt aaacttgatt
    47221 ccttataacc cagttagtga gcatgaccaa tatagccgta gtcccaaaga gcgcgtgttg
    47281 gctttctatg atacgcttaa gaaaaaaggg ggcaactgtg tggttcgtca agagcatggt
    47341 acagatattg acgcagcttg tggacaattg cgctttaaca caatgaaacg tgaccgccag
    47401 aaggcagtcg cagcggtaaa tccttaatga tgaagaagac ttataatcat attttggtct
    47461 ggggagtcat tttctatagc atttgcattg tctgtttttg ctttactcct caagaacaat
    47521 ctaccgtggg agtgggaact ccaggtattc agcatcttgg acgcctggtt tttcttttga
    47581 ctcctttcaa ttctctctgg aaactgggcg aagtgagtga cattggacaa ttatgttgga
    47641 tttttttaca aaatatcctc aatgtcttct tgttttttcc tctgattttc caactccttt
    47701 atctatttcc aaatttgcgg aaaacaaaaa aggtccttct ttttagtttt cttgtgagtc
    47761 ttggaatcga gtgtacgcaa ttaatcttgg actttttctt tgatttcaat cgcgtctttg
    47821 agattgatga tttgtggacc aacactttgg gtggctatct ggcttggctc ctttataaac
    47881 gattacataa aaacaaggta aggaattaaa atgagtattt tagaagttaa aaatctgagt
    47941 cacggttttg gtgaccgtgc aatttttgaa gatgtgtcct tccgtctcct caagggagaa
    48001 catatcggcc tggtcggtgc caatggtgaa ggaaaatcaa cctttatgag tatcgtgact
    48061 ggtaaaatgc tgccagatga aggaaaggtt gagtggtcca aatatgtgac ggctggttac
    48121 ttggatcagc actctgtcct tgctgaaaga cagtcggtgc gtgatgttct ccgtacggct
    48181 tttgatgagc ttttcaaagc tgaagctcgt atcaatgacc tctatatgaa aatggctgaa
    48241 gacggcgcgg atgttgatgc tctcatggaa gaagtaggag aacttcaaga ccgtctggag
    48301 agtcgtgatt tctatacctt ggatgctaag attgacgaag tagcgcgtgc tcttggtgtt
    48361 atggactttg gcatggatac ggatgtaact tctttgtcag gtgggcaaag aaccaaggtg
    48421 cttttggcaa aacttctcct tgaaaagcct gatatcttgc tgttggacga gccgaccaac
    48481 tacttggatg ctgagcatat tgattggctc aagcgctatc tccaaaacta tgagaatgcc
    48541 tttgttctca tttcgcacga tattccattc ctcaatgacg ttattaatat tgtctatcat
    48601 gtggaaaatc aacagctgac gcgttactct ggtgactact accagttcca agaagtttat
    48661 gctatgaaga aatctcagct agaggcagcc tacgaacgcc agcagaaaga gattgcagac
    48721 ctcaaggact ttgtggctcg taataaagcc cgtgttgcaa ctcgtaatat ggctatgtct
    48781 cgtcaaaaga aattggataa gatggatatt atcgaactcc aaagtgagaa accaaaacca
    48841 tcctttgatt tcaaaccagc tcgtacacca gggcgcttta tcttccaagc caagaacttg
    48901 caaattggtt acgaccgtcc tcttactaag cctttaaatc ttaccttcga acgcaatcaa
    48961 aaggttgcga ttattggtgc taatggtatt ggaaaaacaa ctctcttgaa gagtctcttg
    49021 ggcattatct cgccaatcgc tggggaagtg gagcgtggag attatttaga acttggttat
    49081 tttgagcagg aagtagaagg cggtaatcgc caaactcctc ttgaagctgt ctggaatgcc
    49141 tttcctgccc ttaatcaagc agaagtccgt gcagcccttg cccgttgtgg tttgacaacc
    49201 aaacatattg aaagccagat tcaagtatta tcagggggag agcaagccaa ggttcgtttc
    49261 tgtctcttga tgaatcgtga aaacaacgtt ttagtgctgg acgagccgac caaccatttg
    49321 gatgtggatg caaaggatga gctcaaacgc gctctcaaag aatatagggg atctatcctt
    49381 atggtctgcc acgagccaga cttttatgaa ggctggatag accaaatatg ggattttaat
    49441 aatttaactt aagaatgaga gtaaaagaaa tacagtaccg aatgtggata ctgtattttt
    49501 ttggttttta agatttaaaa tcgtagtctt tcaccacttc gatgctgtcg attgtgatag
    49561 cagtagttgg cttgtctttt tcatcttttt cggccttagc aatcttatcc acaacatcca
    49621 taccgtcaat cacttgacca aagactgggt gtttgccatc tagactaggg tttccacctt
    49681 ctttgtaggc ttcgataatt ttctgtggat acttgcttgt agggagttta gaagaggtat
    49741 ctgtagagct ttggttgatg aagaactggc tgccattggt gtttggttga ccagtattag
    49801 ccatagcaag agcaccacgg atgttataca aataaggagt aatctcgttc ttgaaaccag
    49861 ttcctttgtc tttagtctta tccttgtcat gccagatgga ctgaccacct gtaccgtccc
    49921 cttttggatc tccagtttgg accataaagc catcgatgac acggtggaag gtaataccgt
    49981 tatagtagcc ttctttggca tgagtgagga aattttcaac cgctagagga gcgagtttag
    50041 ggaagagttt aatgcgaata tcaccttggc ttgtgtggag aatcacttcg gcttcatctt
    50101 cagcaacttc cttagatagt tgtgggaaat tggcgttttc gtttgttaat gcatcgttta
    50161 actccttggc agattgggca gctactttgg aactttcttc agcagcaaga ctggaatcaa
    50221 cataatcatc accacgcaga ctgcgttgga cgctgctaca cccagctagg gctacagtag
    50281 acagtaaaag aagggttgct agttttttca ttctgatcct ctcaaaaatt catttataac
    50341 cattgtaccc taaaaggaag tggatttcaa atattagtag tttacagaac tggcttagat
    50401 aatagttggg atttcatcat catcttgaaa atcttcaact tcttccccag taaatggttt
    50461 ctgaaaagaa cttagtataa aacgggcaat tggttcaacg attaggaaat ttagaggaag
    50521 agctgcaata aagtttacga accaggcgct tagataggta ttgggtgtga tagcaatgcc
    50581 attgtaaaaa agtccataga aggacatgaa agtgaccagc taattcttct tctgaaaaat
    50641 gctcatgaag ggcttgatcc aggtcgcaag atttcatttt agaaagtcca gtaactccct
    50701 tcttcttcag gatattcttt ttcatggtat tatttagatg gtcaagtgag tcaaaagaag
    50761 tttcgacaag agcataccct ttttctacca gagtttttag atgtttaggg gcatcaatac
    50821 cataagtgta ctcaaagtat tttggaaacc agatcttaag aaagctcgta aagctagcca
    50881 gttctctaaa cgctaagaac tagctacaac acagcattta caacacttca tggttcacac
    50941 catggggtgt tttttaatga ttttaagcaa aattcacact taattgaaag ttatttaaat
    51001 tagatgaaaa tttatttttt gaaaaagtcg gaaaacattg attctaagcg aattttgaat
    51061 catattcgaa tgggagtttt taaaatcatg tttcagtggt aaaagtacca aactggattc
    51121 tccatagtaa aatgatatct cctgctagtg aatcatctac taataagtcc atatttcgct
    51181 tgggaacggg cttgggactt agaagccaag tatccaactc tcgttcaggc gatatgaagg
    51241 gtttgacttg gtgtttttta taaaattttt ctaaaatagt attcacggat agcatctttc
    51301 aaacatttat ttcctattct aacaaatttc taaatacttt aagaaattta tagtctgtca
    51361 agtttttttc ttgacacatg ccagaaatct gctataatag aacatgtgct aaatagctca
    51421 gctatttcac cgaaataaaa aattaaagaa atgagacttt aaaaatggca gttaaaatcc
    51481 gtttgactcg tatgggttct aagaaaaaac ctttctaccg tatcaacgta gcagattcac
    51541 gttcaccacg tgacggacgt ttcatcgaaa cagttggaac ttacaaccca cttgttgctg
    51601 aaaaccaagt aactttgaaa gaagatcgcg ttcttgcatg gttggctaat ggagctcaac
    51661 cttcagacac agtacgtaac atcctttcaa aagaaggcgt attgaaaaaa ttccacgatt
    51721 ctaaattttc aaaataagtt taaagtaggt tgacagatgg atacgattga aaatctcatt
    51781 attgcgattg tgaaaccctt aatttcacaa ccagatgcct taactatcaa gattgaggat
    51841 acaccagaat ttttggaata tcatttgaat cttgatcaaa gcgatgtggg tcgtgtaatc
    51901 ggtcgtaagg gtcgcactat ttctgcgata agaacgattg tctactctgt cccaactgaa
    51961 tacaaaaaag taagaatcgt tattgacgaa aaataagaag ggcgggacgg atgtctcgct
    52021 tttttgtgtg gaatagaaga tatagtaaaa tgaaacaaga acaggacaaa tcgatcagga
    52081 cagtcaaatc gatttctaac aatgttttag aagtaaaggt gtactattct agtttcaata
    52141 tactataaaa gattgaacgt ttaggcaatt ccaagactac ttaatcgaac attaa
//
LOCUS       DAVHIZ010000006        51884 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.006, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000006 DAVHIZ010000000
VERSION     DAVHIZ010000006.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 51884)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 51884)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..51884
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.006"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(214..576)
                     /locus_tag="VVO18_000377"
     CDS             complement(214..576)
                     /locus_tag="VVO18_000377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895063.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein-export chaperone SecB"
                     /protein_id="HEU5585592.1"
                     /translation="MLEVGLNSLINLFTFTFDILYPIVKVGHADDYSHGAVKLSVSLV
                     DKDAMKKISVTVIGYFEINIDENITDILYVNGTAILCPYLRSIVSTVSAIDSSEAMLL
                     PTINVLELLDKSQPFEEE"
     gene            590..736
                     /locus_tag="VVO18_000378"
     CDS             590..736
                     /locus_tag="VVO18_000378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585593.1"
                     /translation="MKTKEQTRKLAVGCSKHCFEVVDRTDEVSNHTHGKATLTWFEEI
                     FEEY"
     gene            complement(1328..2017)
                     /gene="rplA"
                     /locus_tag="VVO18_000379"
     CDS             complement(1328..2017)
                     /gene="rplA"
                     /locus_tag="VVO18_000379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145049.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L1"
                     /protein_id="HEU5585594.1"
                     /translation="MAKKSKQLCAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEV
                     AYNLNIDVKKADQQIRGAMVLPNGTGKTSRVLVFARGAKAEEAKAAGADFVGEDDLVA
                     KINDGWLDFDVVIATPDMMALVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGK
                     ITYRADRAGNVQAIIGKVSFEAEKLVENFKAFNETIQKAKPATAKGTYVTNLTITTTQ
                     GVGIKVDVNSL"
     gene            complement(2225..2650)
                     /gene="rplK"
                     /locus_tag="VVO18_000380"
     CDS             complement(2225..2650)
                     /gene="rplK"
                     /locus_tag="VVO18_000380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004226069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11"
                     /protein_id="HEU5585595.1"
                     /translation="MAKKVEKLVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNA
                     RTADQAGMIIPVVISVYEDKSFTFVTKTPPAAVLLKKAAGVEKGSGTPNKTKVATVTR
                     AQVQEIAETKMPDLNAANVESAMRMIEGTARSMGFTVVD"
     gene            2782..2919
                     /locus_tag="VVO18_000381"
     CDS             2782..2919
                     /locus_tag="VVO18_000381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585596.1"
                     /translation="MKIKEQTRKLAAGCSKYSFEIADKTDEVSSKHCFEVVNRTDAVS
                     R"
     gene            complement(2959..3675)
                     /locus_tag="VVO18_000382"
     CDS             complement(2959..3675)
                     /locus_tag="VVO18_000382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747760.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M15 family metallopeptidase"
                     /protein_id="HEU5585597.1"
                     /translation="MKKRYVILSGLLALTLAACSQEKTKVEENTQKTEQSSQPEGTVG
                     SKSQASSQKKAEVSNKGSYYSIQGKYDEIILANKRYPLSKDYNPGENPTAKAELLKLI
                     AAMQAEGYPISDQYSGFRSYETQAKLYQDYVNQDGKEAADRYSARPGYSEHQTGLAFD
                     LIGTDGDLVTEEKAAQWLLDHAADYGFVVRYLKGKEKETGYMAEEWHLRYVGKEAKEI
                     AASGLSLEEYYGFEGGDYVD"
     gene            complement(3693..4154)
                     /locus_tag="VVO18_000383"
     CDS             complement(3693..4154)
                     /locus_tag="VVO18_000383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEU5585598.1"
                     /translation="MCLICQRIELIKAGQNPYFVKELETGYVVIGDHQYFKGYTLFLA
                     KDHVTELHHMETSVKLRFLEEMSLVQEAVAKAFEAEKMNIELLGNGDAHAHWHLFPRR
                     AGDMKSHGLNGRGPVWWVPWEEMAAEDCQVQSPELEEMIKILSHELEKYLA"
     gene            complement(4156..5193)
                     /locus_tag="VVO18_000384"
     CDS             complement(4156..5193)
                     /locus_tag="VVO18_000384"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077216.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M42 family metallopeptidase"
                     /protein_id="HEU5585599.1"
                     /translation="MNQTVEYIKELTAIASPTGFTREISNYLVKTLEGFGYQPVRTAK
                     GGVNVTIKGQNDEQHRYVTAHVDTLGAIVRAVKPDGRLKLDRIGGFPWNMIEGENCTV
                     HVASTGQKVSGTILIHQTSCHVYKDAGTAERTQDNMEVRLDVKVSNEKETRALGIEVG
                     DFISFDPRTVVTDTGFIKSRHLDDKVSAAILLNLLRVYKEEGIDLPMTTHFAFSVFEE
                     VGHGANSNIPEEVVEYLAVDMGAMGDDQQTDEYTVSICVKDASGPYHYDFRQHLVALA
                     KEQDIPFKLDIYPFYGSDASAAMSAGAEVKHALLGAGIESSHSYERTHIDSVVATERM
                     VDAYLKSEAVS"
     gene            complement(5291..6616)
                     /gene="brnQ"
                     /locus_tag="VVO18_000385"
     CDS             complement(5291..6616)
                     /gene="brnQ"
                     /locus_tag="VVO18_000385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152071.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid transport system II
                     carrier protein"
                     /protein_id="HEU5585600.1"
                     /translation="MAKKGTLTGLLLFGIFFGAGNLIFPPSLGALSGEHFLPAIAGFV
                     FSGVGIAVLTLIIGTLNPKGYIYEISTKIAPWFATLYLSVLYLSIGPFFATPRTATTA
                     YEVGISPLLSDANKGLGLIVFTVLYFAAAYLISLNPSKILDRIGRILTPVFAILIVIL
                     VVLGAIKYGGTSPQAASAAYQASAFGTGFLEGYNTLDALASVAFSVIAVQTLKQLGFS
                     SKKEYISTIWVVGIVVALAFSALYIGLGFLGNHFPVPAEAMKGGTPGVYILSQATQEI
                     FGSTAQLFLAAMVTVTCFTTTVGLIVSTAEFFNERFPQISYKVYATAFTLIGFAIANL
                     GLDAIIKYSIPVLVILYPITIAIVMIVIVNKFVALSKPGMQLTIAVVTVIAIANVLGS
                     SFKVEFLANLVSVLPFAKASLPWLVPAIVGILLSLVLPNKQESDVFEME"
     gene            complement(6787..6879)
                     /locus_tag="VVO18_000386"
     CDS             complement(6787..6879)
                     /locus_tag="VVO18_000386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU5585601.1"
                     /translation="MRSARACQFLLEQGYNVINVQGGMLAFEEL"
     gene            complement(6922..7074)
                     /locus_tag="VVO18_000387"
     CDS             complement(6922..7074)
                     /locus_tag="VVO18_000387"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU5585602.1"
                     /translation="MKEIAFDAFYQLYQNDQLSLVDVREVDEFAALHLEGAHNLPLSQ
                     LADSYD"
     gene            complement(7234..7812)
                     /locus_tag="VVO18_000388"
     CDS             complement(7234..7812)
                     /locus_tag="VVO18_000388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase family protein"
                     /protein_id="HEU5585603.1"
                     /translation="MSQIERIKQAIMADSQNASYTERGIEPLFAAPKTARINIIGQAP
                     GLKTQEAGLYWKDKSGDRLRDWLGVDEDTFYNSGYFAVLPMDFYFPGHGKSGDLPPRT
                     GFAEKWHPQLLQELPDIQLTLLIGQYAQAYYLQEKISGKVTERVKHYKDYLPAYFPLV
                     HPSPRNQIWMAKNPWFEAEVVPDLKKRIKTIL"
     gene            complement(7866..9266)
                     /gene="pepV"
                     /locus_tag="VVO18_000389"
     CDS             complement(7866..9266)
                     /gene="pepV"
                     /locus_tag="VVO18_000389"
                     /EC_number="3.4.13.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125034.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase PepV"
                     /protein_id="HEU5585604.1"
                     /translation="MIAIDFTAEVEKRKEDLLADLFSLLEINSERDDSKADAQHPFGP
                     GPVKALEKFLEIADRDGYPTKNVDNYAGHFEFGDGEEVLGIFAHMDVVPAGSGWDTDP
                     YTPTIKDGRLYARGASDDKGPTTACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADM
                     DYYFEHVGLAKPDFGFSPDAEFPIINGEKGNITEYLHFAGENTGAARLHSFTGGLREN
                     MVPESATAVVSGDLADLQAKLDAFVAEHKLRGELQEEAGKYKVTIIGKSAHGAMPASG
                     VNGATYLALFLSQFGFAGPAKDYLDIAGKILLNDHEGENLKIAHVDEKMGALSMNAGV
                     FRFDETSADNTIALNIRYPKGTSPEQIKSILENLPVASVSLSEHGHTPHYVPMEDPLV
                     QTLLNVYEKQTGLKGHEQVIGGGTFGRLLERGVAYGAMFPDSIDTMHQANEFIALDDL
                     FRAAAIYAEAIYELIK"
     gene            complement(9279..9884)
                     /locus_tag="VVO18_000390"
     CDS             complement(9279..9884)
                     /locus_tag="VVO18_000390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002924506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nitroreductase family protein"
                     /protein_id="HEU5585605.1"
                     /translation="MKFLELNKKRHATKHFTDKPVDPKDVRTAIEIATLAPSAHNSQP
                     WKFVVVREKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRARKIARVGGANNFSE
                     EQLQYFMKNLPAEFARYSEQQVSDYLALNAGLVAMNLVLALTDQGIGSNIILGFDKSK
                     VNEVLEIEDRFRPELLITVGYTDDKLEPSYRLPVDEIIEKR"
     gene            10055..10855
                     /locus_tag="VVO18_000391"
     CDS             10055..10855
                     /locus_tag="VVO18_000391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5585606.1"
                     /translation="MKKFSLLLAILPFLVACGNQATPKETSAQKTIVLATAGDVPPFD
                     YEDKGNLTGFDIEVLKAVDEKLSDYEIQFQRTAWESIFPGLDSGHYQAAANNLSYTKE
                     RAEKYLYSLPISNNPLVLVSNKKNPLTSLDQIAGKTTQEDTGTSNAQFINNWNQKHTD
                     NPATINFSGEDIGKRILDLANGEFDFLVFDKVSVQKIIKDRGLDLSVVDLPSADSPSN
                     YIIFSSDQKEFKEQFDKALKEFYQDGTLEKLSNTYLGGSYLPDQSQLQ"
     gene            complement(11037..11870)
                     /locus_tag="VVO18_000392"
     CDS             complement(11037..11870)
                     /locus_tag="VVO18_000392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001015777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase family protein"
                     /protein_id="HEU5585607.1"
                     /translation="MNHKIAILSDIHGNVTALEAVIADAKNQGVSEYWLLGDIFLPGP
                     GANDLVALLKDLPITASVRGNWDDRVLEALDGQYGLEDPQEVQLLRMTQYLMERMDPA
                     TIVWLRSLPLLEKKEIDGLRFSISHNLPDKNYGGDLLVENDTEKFDQLLDAETDVAVY
                     GHVHKQLLRYGSQGQQIINPGSIGMPYFNWEALKNHRAQYAVIEVEDGELVNILFRKV
                     AYDYEAELEFAKSKGLPFIEMYEELRREDNYQRHNLELLASLIEKHRYVEDVKNFFDF
                     L"
     gene            complement(11860..13704)
                     /gene="uvrC"
                     /locus_tag="VVO18_000393"
     CDS             complement(11860..13704)
                     /gene="uvrC"
                     /locus_tag="VVO18_000393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit UvrC"
                     /protein_id="HEU5585608.1"
                     /translation="MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSY
                     FRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEINLIKENKPKYNIMLKDDKSYPFI
                     KITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
                     YYHIGQCMAHTICKKDEAYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERA
                     AEYRDLIQAIGTLRTKQRVMAKDLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNL
                     FPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKALVDSKILKPQRGEKK
                     QLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGT
                     SPVSAMVVFVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLI
                     VIDGGQGQVNIAKQVIQEELGLDIPIAGLQKNDKHQTHELLFGDPLEVVDLSRNSQEF
                     FLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMKHFKSLTKIKEA
                     SVDEIVEVGVPRVVAEAVQRKLNPQGEALPQVAEERVDYQTEGNHNKP"
     gene            complement(13744..14445)
                     /locus_tag="VVO18_000394"
     CDS             complement(13744..14445)
                     /locus_tag="VVO18_000394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001267193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="matrixin family metalloprotease"
                     /protein_id="HEU5585609.1"
                     /translation="MRWLFRLIGAFFSFVWRLFWRLVWIVVLLCVLAFGLLWYLNGDF
                     QGALKQAERSVKIGQQSIDQWEKTGQLPKLSQTDSHQHSEGRWPQVSARIYLDPQMDS
                     RFQEAYLEAIQNWNQTGAFNFELVTESSKADITATEMNDGGTPVAGEAESQTNLLTGQ
                     FLSVTVRLNHYYLSNPYYGYSYERLVHTAEHELGHAIGLDHTDEKSVMQPAGSFYGIQ
                     EEDVANLRKIYETSE"
     gene            complement(14524..15756)
                     /gene="murN"
                     /locus_tag="VVO18_000395"
     CDS             complement(14524..15756)
                     /gene="murN"
                     /locus_tag="VVO18_000395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229509.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurN"
                     /protein_id="HEU5585610.1"
                     /translation="MALTTLTKEEFQTYSDQVSSRSFMQSVQMGDLLEKRGARIVYLA
                     LKQEGEIQVAALVYSLPMLGGLHMELNSGPIYTQQDALPVFYAELKEYAKQNGVLELL
                     VKPYETYQTFDSQGNPIDAEKKSIIQGLTDLGYQFDGLITGYPGGEPDWLYYKDLTEL
                     TEKSLLKSFSKKGKPLVKKAETFGIRLKKLKREELSIFKNITKETSERREYSDKSLEY
                     YEHFYDTFGEQAEFLIASLNFSDYMSKLQGEQSKLEENLDKLRLDLSKNPHSEKKQNQ
                     LREYSSQFETFEVRKAEARDLIEKYGEEDIVLAGSLFVYMPQETTYLFSGSYTEFNKF
                     YAPALLQKYVMLESIKRGIPKYNFLGIQGIFDGSDGVLRFKQNFNGYIVRKAGTFRYH
                     PSPLKYKAIQLLKKIVGR"
     gene            complement(15761..16981)
                     /gene="murM"
                     /locus_tag="VVO18_000396"
     CDS             complement(15761..16981)
                     /gene="murM"
                     /locus_tag="VVO18_000396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001819885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan bridge formation alanyltransferase
                     MurM"
                     /protein_id="HEU5585611.1"
                     /translation="MYRYQIGIPTLEYDQFVKEHELANVLQSSAWEEVKSNWQHEKFG
                     VYREEKLLATASILIRTLPLGYKMFYIPRGPILDYGDKELLNFAIQSIKSYARSKRAV
                     FVTFDPSICLSQSLINQEKTEFPENLAIIDSLQQMGVRWSGKTEEMGDTIQPRIQAKI
                     YKENFEEDKLSKSTKQAIRTARNKGLEIQYGGLELLDSFSELMKKTEKRKEIHLRNEA
                     YYKKLLDNFKDKAYITLATLDVSKRSQELEEQLAKNRALEETFTESTRISKVEAQKKE
                     KERLLEELTFLQEYIDVGQARVPLAATLSLEFGTTSVNIYAGMDDDFKRYNAPILTWY
                     ETARYAFERGMVWQNLGGVENSLNGGLYHFKEKFNPTIEEYLGEFTMPTHPLYPLLRL
                     ALDFRKTLRKKHRK"
     gene            complement(17093..17872)
                     /locus_tag="VVO18_000397"
     CDS             complement(17093..17872)
                     /locus_tag="VVO18_000397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
                     /protein_id="HEU5585612.1"
                     /translation="MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLH
                     GMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLK
                     RFFPNMTSKREKTFIAGLSMGGYGCFKLALATNRFSHAASFSGALSFQDFSPESQNLG
                     TPAYWRGVFGEIKDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKK
                     LGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT"
     gene            complement(17941..19602)
                     /locus_tag="VVO18_000398"
     CDS             complement(17941..19602)
                     /locus_tag="VVO18_000398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEU5585613.1"
                     /translation="MSNISLTTLGGVRENGKNMYIAEIGESIFVLNVGLKYPENEQLG
                     VDVVIPNMDYLFENSDRIAGVFLTHGHADAIGALPYLLAEAKVPVFGSELTIELAKLF
                     VKGNDAVKKFNDFHVIDENTEIDFGGTVVSFFPTTYSVPESLGIVLKTSEGSIVYTGD
                     FKFDQTASESYATDFARLAEIGRDGVLALLSDSANADSNIQVASESEVRDEITQTIAD
                     WEGRIIVAAVSSNLSRIQQIFDAADKTGRRIVLTGFDIENIVRTAIRLKKLSLANEIL
                     LIKPKDMSRFEDHELIILETGRMGEPINGLRKMSIGRHRYVEIKDGDLVYIATAPSIA
                     KEAFVARVENMIYQAGGVVKLITQSLHVSGHGNVRDLQLMINLLQPKYLFPVQGEYRE
                     LDAHAKAAMAVGMLPERIFIPKKGTTMAYENGDFVPAGSVSAGDILIDGNAIGDVGNV
                     VLRDRKVLSEDGIFIVAITVNRREKKIVARARVHTRGFVYLKKSRDILRESSELINQT
                     VEEYLQGDDFDWADLKGKVRDNLTKYLFDQTKRRPAILPVVMEAK"
     gene            complement(19777..21999)
                     /gene="recJ"
                     /locus_tag="VVO18_000399"
     CDS             complement(19777..21999)
                     /gene="recJ"
                     /locus_tag="VVO18_000399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001832038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="HEU5585614.1"
                     /translation="MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQDQ
                     ESLKKFLEPSLEDLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVK
                     ESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQ
                     SMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQV
                     ELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIGANEVTEET
                     VGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEA
                     KTMVDPEKKVQVLAKEGWNPGVLGIVAGRLLEELGQTVIVLNIEDGRAKGSARSVEAV
                     DIFEALDPHRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNL
                     DEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISK
                     GEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFN
                     IRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKN
                     DIDKAYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFE
                     ELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE
                     "
     gene            22276..23034
                     /locus_tag="VVO18_000400"
     CDS             22276..23034
                     /locus_tag="VVO18_000400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5585615.1"
                     /translation="MALVEFKNVEKYYGDYHALRNINLRFEKGQVVVLLGPSGSGKST
                     LIRTINGLEAVDKGSLLVNGHQVAGASQKDLVPLRKEVGMVFQHFNLYTHKTVLENVT
                     LAPVKVLGIDKKEAEKTAQKYLEFVNMWDKKDSYPAMLSGGQKQRIAIARGLAMHPEL
                     LLFDEPTSALDPETIGDVLAVMQKLAHDGMNMIIVTHEMGFAREVADRIIFMADGEVL
                     VDTTDVDNFFDNPSEPRAQQFLSKIINHESDKVK"
     gene            23045..23839
                     /locus_tag="VVO18_000401"
     CDS             23045..23839
                     /locus_tag="VVO18_000401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000726191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU5585616.1"
                     /translation="MKKKFFLSALLISLFGLAAAKPVQADTSIADIQKRGELVVGVKQ
                     DVPNFGYKDPKTGTYSGIETDLAKMVADELKVKIRYVPVTAQTRGPLLDNEQVDMDIA
                     TFTITDERKKLYNFTSPYYTDASGFLVNKSAKIKKIEDLNGKTIGVAQGSITQRLITE
                     LGKKKGLKFKFVELGSYPELITSLHAHRIDAFSVDRSILSGYTSKRTALLDDSFKPSD
                     YGIVTKKSNTEFNDYLDNLVTKWSKDGSLQKLYDRYKLKPSSHTAD"
     gene            23852..24529
                     /locus_tag="VVO18_000402"
     CDS             23852..24529
                     /locus_tag="VVO18_000402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5585617.1"
                     /translation="MTDLSSWTAYFQDFGQFFNGFLFTLALAIGSFILAMVLGIFFGA
                     MSTSKRPILRILARIFVEFYQNTPLLVQFVIVFYGLPLISDHTIMIPIYWTAVLCVGL
                     YHGAYIAEVIRSGIQSIPSGQMEAALSQGFTYISAMRLIILPQAFRIILPPLTNQIVN
                     LIKNTSTVAIISGVDLMFVTKSWSALNGNYIPGFLGAALLYFALCFPVAQFGRKMEQV
                     NKKAYSL"
     gene            24539..25198
                     /locus_tag="VVO18_000403"
     CDS             24539..25198
                     /locus_tag="VVO18_000403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5585618.1"
                     /translation="MESILEVLTPDNLVFIFKGFGLTLYISLIAIILSTIIGTVLAVM
                     RNGKNPILRIISSIYIEFVRNVPNLLWIFTIFLVFKMKSTPAGITAFTLFTSAALAEI
                     IRGGLNAVDKGQYEAGMSQGFTSAQILYYIILPQAIRKMLPAIISQFVTVIKDTSLLY
                     SVIALQELFGASQILMGRYFEPEQVFSLYILIALIYFSFNLAISNLSHMLAKRWQQAA
                     E"
     gene            25342..26532
                     /locus_tag="VVO18_000404"
     CDS             25342..26532
                     /locus_tag="VVO18_000404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835812.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="HEU5585619.1"
                     /translation="MKSIKGLLFIIASFILTLLTWMNTSPQFMIPGLALTSLSLTFIL
                     ATRLPLLESWFHGLEKVYTVHKFTAFLSIILLIFHNFSMGGLWGSRLAAQFGNLAIYI
                     FASIILVAYLGKYIQYEAWRWIHRLVYLAYILGLFHIYMIMGNRLLTFNLLSFLVGSY
                     ALLGLLAGFYIIFLYQKISFPYLGKITHLKRLNHDTREIQIHLSRPFNYQSGQFAFLK
                     IFQEGFESAPHPFSISGGHGQTLYFTVKNSGDHTKNIYDNLQAGSKVTLDRAYGHMII
                     EEGRENQVWIAGGIGITPFISYIREHPILDKQVHFYYSFRGDENAVYLDLLRNYAQKN
                     PNFELHLIDSTKDGYLNFEQKEVPEHATVYMCGPISMMKALAKQIKKQNPKTELIYEG
                     FKFK"
     gene            complement(26853..27734)
                     /locus_tag="VVO18_000405"
     CDS             complement(26853..27734)
                     /locus_tag="VVO18_000405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001018994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-bisphosphate aldolase"
                     /protein_id="HEU5585620.1"
                     /translation="MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAP
                     VLIQTSMGAAKYMGGYKVARNLIANLVESMGITVPVAIHLDHGHYEDALECIEVGYTS
                     IMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDAK
                     AMVETGIDFLAAGIGNIHGPYPVNWEGLDLDHLQKLTEALPGFPIVLHGGSGIPDEQI
                     QAAIKLGVAKVNVNTECQIAFANATRKFARDYEANEAEYDKKKLFDPRKFLADGVKAI
                     QASVEERIDVFGSEGKA"
     gene            complement(27875..29203)
                     /gene="vncS"
                     /locus_tag="VVO18_000406"
     CDS             complement(27875..29203)
                     /gene="vncS"
                     /locus_tag="VVO18_000406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase VncS"
                     /protein_id="HEU5585621.1"
                     /translation="MKRTGLFTKIFIYTFSIFSVLVICLHLAIYFLFPSTYLSHRQET
                     IGQKATAIAQSLEGKDRQSIEQVLDLYSQTSDIKGTVKGEMTEDKLEVKDSLPLDTDR
                     QTTSLFIEEREVKTQDGGTMILQFLASMDLQKEAEQISLQFLPYTLLASFLISLLVAY
                     IYARTIVAPILEIKRVTRRMMDLDSQVRLRVDSKDEIGNLKEQINSLYQHLLTVIADL
                     HEKNEAILQLEKMKVEFLRGASHELKTPLASLKILIENMRENIGRYKDRDQYLGVALG
                     IVDELNHHVLQILSLSSVQELRDDRETIDLLQMTKNLVKDYALLAKERELQIDNSLTH
                     QQAYLNPSVMKLILSNLISNAIKHSVPGGLVRIGEREGELFIENSCSSEEQEKLAQSF
                     SDNASRKVKGSGMGLFVVKSLLEHEKLAYRFEMEENRLTFFIAFPKVVQD"
     gene            complement(29200..29856)
                     /gene="vncR"
                     /locus_tag="VVO18_000407"
     CDS             complement(29200..29856)
                     /gene="vncR"
                     /locus_tag="VVO18_000407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor VncR"
                     /protein_id="HEU5585622.1"
                     /translation="MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYE
                     VALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPF
                     SLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
                     KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCIFTVRNVGYKLERK
                     "
     gene            complement(29905..29988)
                     /gene="pep27"
                     /locus_tag="VVO18_000408"
     CDS             complement(29905..29988)
                     /gene="pep27"
                     /locus_tag="VVO18_000408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_198523890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative autolysis signal peptide Pep27"
                     /protein_id="HEU5585623.1"
                     /translation="MRKEFHNVLSSGQLLTDKRPARDYNRK"
     gene            complement(30167..31546)
                     /gene="vex3"
                     /locus_tag="VVO18_000409"
     CDS             complement(30167..31546)
                     /gene="vex3"
                     /locus_tag="VVO18_000409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease subunit Vex3"
                     /protein_id="HEU5585624.1"
                     /translation="MLHNAFAYVTRKFFKSIVIFLIILLMASLSLVGLSIKGATAKAS
                     QETFKNITNSFSMQINRRVNQGTPRGAGNIKGEDIKKITENKAIESYVKRINAIGDLT
                     GYDLIETPETKKNLTADRAKRFGSSLMITGVNDSSKEDKFVSGSYKLVEGEHLTNDDK
                     DKILLHKDLAAKHGWKVGDKVKLDSNIYDADNEKGAKETVEVTIKGLFDGHNKSAVTY
                     SQELYENTAITDIHTAAKLYGYTEDTAIYGDATFFVTADKNLDDVMKELNGISGINWK
                     SYTLVKSSSNYPALEQSISGMYKMANLLFWGSLSFSVLLLALLLSLWINARRKEVGIL
                     LSIGLKQASILGQFITESILIAIPALVSAYFLANYTARAIGNTVLANVTSGVAKQASK
                     AAQASNLGGGAEVDGFSKTLSSLDISIQTSDFIIIFVLALVLVVLVMALASSNLLRKQ
                     PKELLLDGE"
     gene            complement(31598..32245)
                     /gene="vex2"
                     /locus_tag="VVO18_000410"
     CDS             complement(31598..32245)
                     /gene="vex2"
                     /locus_tag="VVO18_000410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding subunit Vex2"
                     /protein_id="HEU5585625.1"
                     /translation="MTLLQLQDVTYRYKNTAEAVLYQIDYNFEPGKFYSIIGESGAGK
                     STLLSLLAGLDSPVEGSILFQGEDIRKKGYSYHRMHHISLVFQNYNLIDYLSPLENIR
                     LVNKKASKDTLLELGLDESQIKRNVLQLSGGQQQRVAIARSLVSEAPVILADEPTGNL
                     DPKTAGDIVELLKSLAQKTGKCVIVVTHSKEVAQASDITLELKDKKLTETRNTSK"
     gene            complement(32258..33535)
                     /locus_tag="VVO18_000411"
     CDS             complement(32258..33535)
                     /locus_tag="VVO18_000411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5585626.1"
                     /translation="MNPIQRSWAYVSRKRLRSFILFLILLVLLAGISACLTLMKSNKT
                     VESNLYKSLNTSFSIKKIENGQTFKLSDLASVSKIKGLENVSPELETVAKLKDKEAVT
                     GEQSVERDDLSAADNNLVSLTALEDSSKDVTFTSSAFNLKEGRHLQKGDSKKILIHEE
                     LAKKNGLSLHDKIGLDAGQSESGKGQTVEFEIIGIFSGKKQEKFTGLSSDFSENQVFT
                     DYDSSQTLLGNSEAQVSAARFYVENPKEMDGLMKQVENLALENQGYQVEKENKAFEQI
                     KDSVATFQTFLTIFLYGMLIAGAGALILVLSLWLRERVYEVGILLALGKGKSSIFLQF
                     CLEVVLVSLGALLPAFVAGNGITTYLLQTLLASGDQASLQDTLAKASSLSTSILSFAE
                     SYVFLVLLSCLSVALCFLFLFRKSPKEILSSIS"
     gene            complement(33892..34062)
                     /locus_tag="VVO18_000412"
                     /pseudo
     CDS             complement(33892..34062)
                     /locus_tag="VVO18_000412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
     gene            complement(34205..34804)
                     /locus_tag="VVO18_000413"
     CDS             complement(34205..34804)
                     /locus_tag="VVO18_000413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166174.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585627.1"
                     /translation="MQILCYFTITVVAKPNNSGEVHLDVSIEDNQGGSGYNFSSVSSS
                     SQTAKYEGTGYNNNSSLYITIDKTSDATALLKLKLNNVDNQPATEVPSSGITVKLNAK
                     DNAGNWTSASNKKEVTVKIVSAKPTYPDKILVKNPDNIKDTEKNAIIEKLKEANKNHP
                     AGAPTFAKGEGEHANDIVATYSDGTTYYVPLNDVTKYAR"
     gene            complement(34941..35825)
                     /locus_tag="VVO18_000414"
     CDS             complement(34941..35825)
                     /locus_tag="VVO18_000414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PucR family transcriptional regulator"
                     /protein_id="HEU5585628.1"
                     /translation="MREKELQDWFPEARISDQPVEKEGYLTLPLASQQWILLEEAGLS
                     EREKQLVALLTQQEQARSLNPWYSYLVEGKGQAPQVFKKIQLVYCHLSYFQQENLTSW
                     LDMMRTLFPNCQTVLQVGAQDYVFVLQQDKYTSVRDILSDTIEAVEYDFGLRLSIMLG
                     QVWSQTGHQALSDLIKAERDLFKTWWRQGHQGVHTFSQLYLWSMGERLVDLKPIKECL
                     HQMILDQDQIQEIILSLWENSAVLTKTAQQLYLHRNSLQYKIDKWEELTGLQLKELTD
                     LTLCYQLILGSLSTIVGL"
     gene            complement(35829..36215)
                     /locus_tag="VVO18_000415"
     CDS             complement(35829..36215)
                     /locus_tag="VVO18_000415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148900.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mini-ribonuclease 3"
                     /protein_id="HEU5585629.1"
                     /translation="MIDVNLINGIALAFEGDAVYSMYIRRHLILKGMTKPNKLHQEAT
                     KYVSAKAQARLIALMLEEQVLTEKEEEIYKRGRNTNSHTKAKNADVVTYRMSTGFEAV
                     MGYLHMTENLERLESLVSWCIQKVEG"
     gene            complement(36208..37551)
                     /locus_tag="VVO18_000416"
     CDS             complement(36208..37551)
                     /locus_tag="VVO18_000416"
                     /EC_number="6.1.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002916477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine--tRNA ligase"
                     /protein_id="HEU5585630.1"
                     /translation="MIKIYDTMSRDLREFVPIEDGKIKMYVCGPTVYNYIHVGNARST
                     VAFDTIRRYFEYRGYKVAYISNFTDVDDKIINRAREEGITPQEVADKYIAAFREDVTA
                     LGVKPATRHPRVVEFMADIIRFVEDLIEKGFAYESQGDVYFRVEKSHNYAKLANKTLE
                     DLELGASGRTDEETARKENPVDFALWKSSKPGEISWDSPWGPGRPGWHIECSVMSTEI
                     LGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKAFANYWMHNGFVNIDNVKMSKSLGNF
                     ITVHDALKTLDGQVLRFFFATQHYRKPINFTEKAVRDAETNLKYLKNTYEQPFTGNVD
                     AQELQNFKDKFVAAMDEDFNAANGITVVFEMAKWINSGNYDASVKQALADMLEIFGIV
                     FVEEVLDAEIEDLIQKRQEARANRDFATADQIRDQLVTQGIKLLDTKDGVRWTRD"
     gene            complement(37638..38522)
                     /locus_tag="VVO18_000417"
     CDS             complement(37638..38522)
                     /locus_tag="VVO18_000417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585631.1"
                     /translation="MIQARNKLSQEELSEAKKVINCCQNYDGTYRDPYLSNMLNFDPN
                     MPAFFLYYEKGKLVGLLTVYADDQDVEVTILVHPGHRRQGIARALFTSFERETASFPI
                     RSVTFQTERIFLENHPDFASNWGLIEDEETETWLGKDRRPYPLANVSHLEILLADSSY
                     QDQISQLKFQAFSEEHESREVVDRYVAEALKDPESRLYILLKAGQVIGTCTVDLSSDT
                     NYFYGLAISEPERGKGYGSYLAKSLVNQLIEQNDKEFQIAVEDSNVGAKRLYEKIGFV
                     KQTQVVYLNEKGARDSEV"
     gene            complement(38534..39151)
                     /gene="cysE"
                     /locus_tag="VVO18_000418"
     CDS             complement(38534..39151)
                     /gene="cysE"
                     /locus_tag="VVO18_000418"
                     /EC_number="2.3.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000539958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine O-acetyltransferase"
                     /protein_id="HEU5585632.1"
                     /translation="MGWWRETIDIVKENDPAARTTLEVLLTYPGVKALAAHRLSHFLW
                     KHSFKLLARMHSQFWRFWTQIEIHPGAQIDSGVFIDHGSGLVIGETAIVEKGVLLYHG
                     VTLGGTGKDCGKRHPTVRKGALISAHAQVIGPVEIGENAKVGAAAVVVADVPSDVTVV
                     GIPAKIVRLHGKKDEPVIHAVEEKREYYVNKLEQAKDASHRSSGL"
     gene            complement(39167..41380)
                     /gene="pnp"
                     /locus_tag="VVO18_000419"
     CDS             complement(39167..41380)
                     /gene="pnp"
                     /locus_tag="VVO18_000419"
                     /EC_number="2.7.7.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="HEU5585633.1"
                     /translation="MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAV
                     MSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFA
                     EGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQII
                     INPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQE
                     EIVAAVGKEKAEVELLHVDAELQAEIIAAYNSDLQKAVQVEEKLAREAATQAVKDQVT
                     AVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVV
                     DFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGE
                     TGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGT
                     LALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITAL
                     QMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVD
                     KIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKV
                     DEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNRVEDLVEIGDEVDVKVIKI
                     DEKGRIDASMKALLPRPPKPEHDEKGEKSERPHRPRHHKDHKPKKEFTETPKDSE"
     gene            complement(42065..42931)
                     /gene="metF"
                     /locus_tag="VVO18_000420"
     CDS             complement(42065..42931)
                     /gene="metF"
                     /locus_tag="VVO18_000420"
                     /EC_number="1.5.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000089969.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="HEU5585634.1"
                     /translation="MSCQTPSLSFEVFPPNPAVGNDNIILALQDMQELAPHFISVTAS
                     NNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALR
                     GDIIPDVEPQKDFRYATDLIELIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKV
                     DAGCSSLVTQLFFDNEHFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIH
                     LPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQ
                     ATHALFNHQSLG"
     gene            complement(42995..45244)
                     /gene="metE"
                     /locus_tag="VVO18_000421"
     CDS             complement(42995..45244)
                     /gene="metE"
                     /locus_tag="VVO18_000421"
                     /EC_number="2.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-methyltetrahydropteroyltriglutamate--
                     homocysteine S-methyltransferase"
                     /protein_id="HEU5585635.1"
                     /translation="MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAK
                     HWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQG
                     EKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVG
                     PFTFLQLSDFEEGVKADDFVDSLVVAYQEVFAKLAELGATRIQLDEAALVKDLTAEEK
                     ALFLNLYNKLLADKKGLEVLLQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVK
                     GGFPADKTLYAGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEE
                     FEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAG
                     LTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKE
                     YDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGM
                     RGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKD
                     STLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVH
                     STVASDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVG
                     PGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVE
                     AAKAAREKL"
     gene            complement(45505..45771)
                     /locus_tag="VVO18_000422"
     CDS             complement(45505..45771)
                     /locus_tag="VVO18_000422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5585636.1"
                     /translation="MEGCPSELFSKEEILESDMRVAIMSELIEARYEQGISQKKLEEV
                     SGISQPVIARMETGESSLQLDTVLKVLTSLGKTLAVVPLEQGKS"
     gene            complement(45894..46300)
                     /locus_tag="VVO18_000423"
                     /pseudo
     CDS             complement(45894..46300)
                     /locus_tag="VVO18_000423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001155321.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            46447..47448
                     /locus_tag="VVO18_000424"
     CDS             46447..47448
                     /locus_tag="VVO18_000424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000597989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="HEU5585637.1"
                     /translation="MIKTFLSALSVILFVIPIIAYSFFPSSNLNIWLSTRPILAQIYA
                     FPLATATMASILSFVFFSLSFYKKNKQIRFYSGILLLLSLILLLFGTDKTLSSASNKT
                     KTLKLVTWNVANQIEAQHIERIFSHFDADMAIFPELATNIRGEQENQRIKLLFHQVGL
                     SMANYDIFTSPPTNSGIAPVTVIVKKSYGFYTEAKTFHTTRFGTIVLHSRKQNIPDII
                     ALHTAPPLPGLMEIWKQDLNIIHNQLASKYPKAIIAGDFNATMRHGALAKISSHRDAL
                     NALPPFERGTWNSQSPKLFNATIDHILLPKNHYYVRDLDIVSFQNSDHRCIFTEITF"
     gene            complement(47516..49921)
                     /locus_tag="VVO18_000425"
     CDS             complement(47516..49921)
                     /locus_tag="VVO18_000425"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="HEU5585638.1"
                     /translation="MLVSYKWLKELVDIDVPSQELAEKMSTTGIEVESVESPAADLSK
                     IVVGEVLSCEDVPETHLHVCQVNVGEEEARQIVCGAPNVRAGIKVMVALPGARIADNY
                     KIKKGKIRGLESLGMICSLGELGISDSVVPKEFADGIQILPENTVPGEEVFSYLDLDD
                     EIIELSITPNRADALSMCGVAHEVAAIYDKAVNFKEFTLTETNEAAADALSVSIGTDK
                     APYYAARILDNVIIAPSPQWLQNLLMNEGIRPINNVVDVTNYILLYFGQPMHAFDLDT
                     FEGTDIRVREARAGEKLVTLDGEERDLDVNDLVITVADKPVALAGVMGGQATEISEKS
                     SRVVLEAAVFNGKSIRKTSGRLNLRSESSSRFEKGINVATVNEALDAAASMIAELAGA
                     TVRKGIVSAGELDTSDVEVSSTLADVNRVLGTELSYADVEDVFRRLGFGLSGNADSFT
                     VSVPRRRWDITIEADLFEEIARIYGYDRLPTSLPKDDGTAGELTVTQKLRRQVRTIAE
                     GAGLTEIITYALTTPEKAVEFTAQPSNLTELMWPMTVDRSVLRQNMISGILDTVAYNV
                     ARKNKNLALYEIGKVFEQTGNPREELPNEINSFAFALTGLVAEKDFQTAAVPVDFFYA
                     KGILEALFTRLGLQVTYTATSEIASLHPGRTAVISLGDQVLGFLGQVHPVTAKAYDIP
                     ETYVAELNLSAIEAALQPATPFVEITKFPAVSRDVALLLKAEVTHQEVVDAIQAAGVK
                     RLTDIKLFDVFSGEKLGLGMKSMAYSLTFQNPEDSLTDEEVARYMEKIQVSLEEKVNA
                     EVR"
     gene            complement(49998..50507)
                     /locus_tag="VVO18_000426"
     CDS             complement(49998..50507)
                     /locus_tag="VVO18_000426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619935.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5585639.1"
                     /translation="MIRKVEMADVEVLAKIAKQAFRETFAYDNTEEQLQEYFEEAYSL
                     KTLSTELGNPDSETYFIMHEEEIAGFLKVNWGSAQTERELEDAFEIQRLYVLQKFQGF
                     GIGKQLFEFALELATKNSFSWAWLGVWEHNTKAQAFYNRYGFEKFSQHHFMVGQKVDT
                     DWLLRKKLR"
     gene            complement(50507..51553)
                     /gene="pheS"
                     /locus_tag="VVO18_000427"
     CDS             complement(50507..51553)
                     /gene="pheS"
                     /locus_tag="VVO18_000427"
                     /EC_number="6.1.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="HEU5585640.1"
                     /translation="MSTIEEQLKALREETLASLKQITAGNEKEMQDLRVSVLGKKGSL
                     TEILKGMKDVSAEMRPIIGKHVNEARDVLTAAFEETAKLLEEKKVAAQLASESIDVTL
                     PGRPVATGHRHVLTQTSEEIEDIFIGMGYQVVDGFEVEQDYYNFERMNLPKDHPARDM
                     QDTFYITEEILLRTHTSPVQARAMDAHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQ
                     IEGLVVGKNISMADLQGTLQLIVQKMFGEERQIRLRPSYFPFTEPSVEVDVSCFKCGG
                     EGCNVCKKTGWIEIMGAGMVHPRVLEMSGIDATVYSGFAFGLGQERVAMLRYGINDIR
                     GFYQGDVRFSEQFK"
BASE COUNT        14671 a        11814 c         9765 g        15634 t
ORIGIN      
        1 ctcctcatta ttagcaaggc ttctactgat tataacctaa ttcttagact acttcaagac
       61 taactgtcca ataataatct acagataaat catccactct taatcaaatt ttattcaatc
      121 catctactca ttcccaaaag gttgctgtat aatgcaagac atttttctta ctgattttac
      181 ttttccttac cttcaattta gtgagctaat aaattattct tcttcaaaag gttgagattt
      241 atctagtaac tctaaaacat taatggtagg tagcaacatt gcttcactgc tatcaattgc
      301 cgaaactgtt gaaacaatag aacgtaaata aggacaaaga atagcagtac catttacgta
      361 tagaatatcg gtgatatttt catctatatt tatttcaaaa tatcctatta cagttacaga
      421 tatttttttc atggcatctt tgtcaactaa agaaacacta agttttacgg ctccatgact
      481 ataatcatct gcatgaccaa ccttaactat gggatataat atatcgaagg taaatgtgaa
      541 caaattgatt agggaattta aaccaacttc taacaatgtg ttatactcaa tgaaaaccaa
      601 agagcaaact aggaaactag ccgtaggttg ctcaaaacac tgttttgagg ttgtggatag
      661 aactgacgaa gtcagtaacc atacgcacgg caaggcgacg ttgacgtggt ttgaagagat
      721 tttcgaagag tattagaaag ctcgatggac tattccagat tcattccact agatttcgaa
      781 atcgagtagg ggataatctc tagcccctct cacaccaccg tacgtgccgt tcggcatacg
      841 gcggttcaac taacttttaa cgcatgtcgt tcaaggtaat aatccaaaca cgaaaccagt
      901 ccacgttttt caaggactgg ttttgatata gcacgtttaa gtaccgactt ctgagctact
      961 atagtagatt gaaactagaa tagtacatct cttcttctaa aacattgtta gaaatcgatt
     1021 tggctgccct gatcgattcg tcctactctt atttcatttt actataattg atagtggtcg
     1081 ccccagccag ataccttatc cgctatatag gccttattat cacgttcctg ttcgtagagc
     1141 cacgatttcg ctatcccttc ctctgacgat tcttatttcc tgcgtcagac ttgggaatcg
     1201 ctattgggtt caccggtagc aggtgcccac cgaggactta cacctcagat atacgacatg
     1261 cccgtcgtac atcaaaaaaa gttgagacat ggcgtcttca acttttttac attactttaa
     1321 ctactgatta aagtgagttt acgtcaactt tgataccaac accttgagta gttgtgatag
     1381 tcaagtttgt tacgtaagtt cctttagctg tagctggttt tgctttttgg attgtttcgt
     1441 tgaaagcttt aaagttttca accaattttt cagcttcaaa tgatacttta ccgatgattg
     1501 cttgaacgtt acctgcacgg tcagcacggt aagtgatttt accaccttta gactcttcaa
     1561 ctgctttagc aacatccatt gttacagtac cagttttagg gtttggcatc aagttacgtg
     1621 gtccaaggac acgtccaaga cgtccaacaa gagccatcat atcaggtgta gcgataacta
     1681 cgtcgaagtc caaccaaccg tcgttgattt tagcaacaag gtcatcttca ccaacaaagt
     1741 ctgcaccagc agcttttgct tcttcagctt ttgcaccacg tgcgaaaaca agaacacgtg
     1801 aagttttacc agtaccgttt ggcaatacca ttgctccacg gatttgttgg tcagcttttt
     1861 taacgtcgat gttcaagttg taagcaactt ctacagttgc gtcaaatttt gcaaagttag
     1921 tttcttttgc aagtgctaca gcttcttcta cactgtatgc ttttgtgctg tcgattttct
     1981 caagagcagc acaaagttgt ttgctttttt tagccatttt ctattctcct tgtaagtggt
     2041 tcaatcgatt ttcatctccc acgtcacttc tcgaaatgat gaagtcttgc gggttttcag
     2101 tctactattt ttctcttcct acggccttaa gctcccttgc tgtacccaag tacaagcctc
     2161 agtcacttgc ctagtatgaa aagcaactaa tagactgctg tgagattttc tactgtgtta
     2221 ttgattagtc aacaacagtg aatcccatag aacgagcagt accttcgatc atacgcattg
     2281 cagactctac gtttgctgcg ttcaaatctg gcatcttagt ttctgcaatt tcttgtactt
     2341 gtgcacgagt aactgtagca actttagttt tattaggtgt acctgatcct ttttcaacac
     2401 ctgcagcttt tttcaaaaga acagcagctg gtggtgtttt cgtaacgaaa gtaaatgatt
     2461 tatcttcgta aactgagata acaactggaa tgatcatacc agcttggtca gctgtacgag
     2521 cgttgaactc ttttgtgaat cccatgatgt tgataccagc ttgaccaaga gcaggtccaa
     2581 ccggtggagc tggtgtagct ttaccagcag ggatttgcaa ttttacaagt ttttcgactt
     2641 ttttagccat ttttaaatcc tcctttgtgg ttttggcggt aattagagat ttttacctcc
     2701 cacaagtatg tttttcacat acccctccat tatacactat ttatctggaa ttgcaagaga
     2761 aaagtttatt ttttatactc aatgaaaatc aaagagcaaa ctaggaagct agccgcaggc
     2821 tgctcaaagt acagctttga gattgcagat aaaactgacg aagtcagctc aaaacactgt
     2881 tttgaggttg tgaatagaac cgacgcagtc agtaggtaag gcgacgctga cgtggtttga
     2941 agagattttc gaagagtatt aatcgacgta gtctccgcct tcaaagccat agtactcttc
     3001 caaactgagg ccacttgcag caatttcttt ggcttctttt ccaacgtagc ggagatgcca
     3061 ttcttctgcc atgtagccag tctccttttc cttgccttta agatagcgaa caacaaagcc
     3121 atagtcagcc gcatggtcca agagccactg ggctgccttt tcttcagtaa ctaaatcccc
     3181 atctgtccca atcaaatcaa aagcaagacc cgtctggtgt tcactgtaac ctgggcgtgc
     3241 tgagtagcga tctgctgctt ccttaccatc ttgattgaca tagtcttggt agagcttagc
     3301 ctgagtttca taactcctaa acccactgta ttggtcactg attggatagc cctcagcctg
     3361 catagctgcg attagtttga gcaactctgc cttggctgtt ggattttctc ctggattgta
     3421 atcttttgac aaaggataac gtttattagc taggataatc tcatcgtatt tcccttggat
     3481 actataatag ctccctttat tgctaacttc tgcctttttc tgactagaag cttgagattt
     3541 gctacctaca gttccttccg gttgactgct ttgctccgtt ttttgagtgt tttcttcaac
     3601 tttggttttt tcttgcgaac aagctgcaag ggtcaatgct agtaaaccag ataaaatgac
     3661 atatcttttt ttcatttctt tcttcctctc tcttaggcca aatacttctc caattcatga
     3721 gataagattt taatcatctc ttccagctct ggcgattgta cttggcaatc ttctgccgcc
     3781 atttcttccc agggcaccca ccagactggg ccacggccat tcaaaccgtg actcttcata
     3841 tcacctgctc ttcggggaaa aagatgccaa tgagcgtggg catcgccatt tcctaggagt
     3901 tcaatattca tcttttcagc ctcaaatgct ttggcgactg cttcttggac taaactcatt
     3961 tcctctaaaa agcgaagttt tacagaagtt tccatatgat ggagttctgt gacatgatct
     4021 tttgctaaaa ataaggtata gcccttaaag tattggtggt caccaataac aacatagcct
     4081 gtttctagtt cttttacaaa gtagggattt tgcccagctt taatgagttc gattctctga
     4141 caaattaagc acattctatg ataccgcctc gctcttaaga taagcatcaa ccatacgctc
     4201 agtcgctact actgaatcga tgtgggtgcg ctcataagag tgactggact caataccagc
     4261 tccaagaagt gcatgcttga cctctgcacc tgctgacatc gctgctgaag cgtccgatcc
     4321 gtaaaatgga tagatgtcga gcttaaatgg aatatcttgc tctttcgcca aagctactaa
     4381 gtgttgacgg aagtcatagt gataaggacc ggaagcatcc tttacacaga tagatactgt
     4441 gtactcatcc gtctgttggt catcgcccat agctcccata tccacagcca gatattctac
     4501 tacctcttct ggaatattgg agttagcacc atggcccacc tcttcaaaga ctgaaaaagc
     4561 aaagtgtgtc gtcatcggca agtcaattcc ttcttcttta taaactcgaa ggagatttag
     4621 caaaatcgct gcgctgacct tatcatccaa atgacgagac ttgataaaac ctgtatcagt
     4681 cacaacagtt cgtggatcga agctgataaa atcaccgacc tcaatcccaa gagcacgagt
     4741 ttctttttca ttgcttactt ttacatccaa acgcacttcc atattgtcct gcgtgcgctc
     4801 tgcagttcct gcatccttgt agacatggca agaagtttgg tggatgagga tggttcctga
     4861 taccttttga cctgtgctag ccacatgaac ggtacagttt tcaccttcaa tcatgttcca
     4921 aggaaaacca ccgatacggt ccaatttaag acgaccatct ggtttgacag cacgaacaat
     4981 agcacccagc gtatccacat gagcagtcac atagcgatgt tgctcatcat tttgaccttt
     5041 gatggtcaca ttgacaccac ccttagctgt gcgaactggc tggtaaccaa aaccttctag
     5101 agtcttgact aaataattcg aaatttcacg agtaaagccc gttggcgatg cgatggctgt
     5161 cagttctttg atatattcta ctgtttgatt catttcttca cctctttcgc tacctattat
     5221 aacacattta tcatcggata aaaaaagaaa atcactcctg tagacttggc tacaaaagtg
     5281 atttaagtga ttattccatt tcaaaaacat cgctttcttg cttgtttggt agaaccaatg
     5341 agagcaagat tccaacaatg gctggcacca accatgggag agatgccttg gcaaaaggaa
     5401 gaacgctaac aagatttgca agaaactcaa ccttaaacga gcttcctagt acgtttgcaa
     5461 tggcaataac tgtaaccaca gcaattgtca actgcatacc tggttttgaa agggcaacaa
     5521 atttgttgac aatgacaatc ataacgatag caatcgtgat tgggtacaag ataaccagta
     5581 ctggaattga gtacttgata atcgcatcaa gacccaaatt ggcaatagca aatccaatca
     5641 aggtaaaggc tgtcgcataa accttgtagc tgatttgtgg gaagcgctca ttaaagaact
     5701 cagctgttga cacaatcaaa ccaacagtcg ttgtgaagca ggttacggta accatagctg
     5761 caaggaagag ttgagctgtt gagccaaaga tttcttgagt ggcttgtgac aagatgtaaa
     5821 cacctggtgt tccacccttc atcgcttcag ctggtactgg gaaatgattt ccaagaaaac
     5881 ctaaaccgat gtaaagagcg ctgaaggcaa gggcaacaac gataccaaca acccaaatag
     5941 ttgaaatgta ttctttctta cttgaaaatc caagttgttt caaggtttga actgcgatta
     6001 cgctaaaggc cactgaggca agggcgtcca aggtattgta accttctagg aaacctgtac
     6061 caaaggcaga agcttgataa gcagctgaag cagcttgagg acttgttcca ccatatttga
     6121 tagctcccag aacgaccaag ataacaatca aaattgcaaa gactggcgtt aaaatacgtc
     6181 caatgcggtc taagattttt gatggattaa gcgaaatcaa ataggctgcc gcaaaataca
     6241 gaaccgtaaa tacaatcaag ccaagtcctt tatttgcatc cgacaaaagg gggctaatcc
     6301 ctacttcgta agctgttgta gcagtacgtg gggtagcaaa gaatggaccg attgacaagt
     6361 aaagaactga gaggtaaaga gtcgcaaacc aaggcgctat cttcgttgaa atctcgtaga
     6421 tatatccttt aggatttagc gttccaataa taagggtcaa gacggcgata ccaacgcctg
     6481 aaaagacaaa acctgcgatg gcaggaagaa aatgttctcc agatagagca cctagagaag
     6541 gcggaaaaat caagttcccc gcaccaaaaa atattccaaa caggagcaaa cctgttaggg
     6601 tacctttttt agccataaaa atctccttca tatttataaa atactgacct agtataccac
     6661 gattaggagt ctgaaaaaag catcacgagg caaatattaa atgttttcaa ttttcttaaa
     6721 aataagaatt atctaaaaat aaaactctcc tacccagtcc acaccaagta ggagaaatgc
     6781 aaaattttaa agttcttcaa aggctaacat gccaccctgg acattgataa cattataacc
     6841 ttgttctaac aggaattggc aagcacgcgc cgatctcatt ccagatttgc aaataatata
     6901 atgcaagcga tctttgtcca attaatcata actatcagcc aattgactaa gcggtaggtt
     6961 gtgggcacct tctaaatgaa gagctgcaaa ctcatccact tctctcacat ccactagaga
     7021 aagctggtcg ttttggtaaa gctggtaaaa tgcgtcaaag gctatttctt tcattctttt
     7081 tcttctaata ctcttcgaaa atctcttcaa accacgtcag cgtcgcctta ccgtgcgtat
     7141 gttaccgact tcgtcagttt tatctgcaac ctcaaagctg tactttgagc agcctacgac
     7201 tagcttccta gtttgctctt tgattttcat tgactataaa atggttttaa ttcttttttt
     7261 caaatctggc actacttctg cctcaaacca aggatttttg gccatccaga tttgatttcg
     7321 tggtgatggg tgaactagcg gaaaataggc tggcagatag tctttatagt gtttcaccct
     7381 ctccgttacc ttcccactga ttttctcctg taaatagtag gcttgggcat attgcccaat
     7441 caagagggtt aactgaatat caggcaattc ctgtaagagc tgcggatgcc atttttctgc
     7501 aaaacctgta cgaggcggaa gatcacccga cttgccatgt cctggaaagt agaaatccat
     7561 aggcaaaaca gcaaaataac ctgaattgta aaaggtatct tcatccacac ctagccagtc
     7621 ccgcaagcgg tcaccacttt tatctttcca gtaaaggcct gcttcttgag ttttaagtcc
     7681 cggagcctga ccgatgatat tgatgcgagc agtttttggc gctgcaaaga gaggctcaat
     7741 gccacgctct gtatagctgg cattctgcga atccgccatg atagcctgtt tgattctttc
     7801 gatttgagac atctactttc cctccaaaaa gaagtccaag cataagatct cagacttcta
     7861 tcgttttatt tgatcaattc gtaaatagct tcggcataaa ttgctgctgc tcggaagaga
     7921 tcgtccaagg caataaattc attggcttgg tgcatggtat caattgagtc tgggaacata
     7981 gcaccatagg caactccgcg ctctaacaag cgaccaaagg ttccaccacc gatgacttgt
     8041 tcatgacctt taaggcctgt ttgtttttca tagacattca acaaggtttg cacaagtgga
     8101 tcttccattg gcacatagtg aggggtatga ccatgttctg atagactgac agaagcaact
     8161 ggcaagtttt ctaggattga cttgatttgt tctggacttg ttccttttgg atagcggatg
     8221 ttaagggcaa tggtattatc agcacttgtt tcatcgaagc ggaagacgcc ggcattcata
     8281 gaaagagcac ccatcttttc atccacatga gcaatcttga gattttcacc ctcatgatcg
     8341 ttcaagagaa ttttacctgc gatgtcaagg tagtctttgg ctggaccagc aaagccaaac
     8401 tggctgagga agagggctag gtaagtcgca ccattgacac ctgaagcagg catagcaccg
     8461 tgggctgatt taccaatgat cgtcaccttg tatttgccag cttcttcttg gagttctcct
     8521 ctaagtttgt gttctgcaac aaaggcatct agtttagctt gcaagtcagc caaatcacct
     8581 gaaacgactg ctgttgctga ttctggtacc atattttcac gtaaaccacc tgtaaagctg
     8641 tgaagacggg cagcacctgt attttctcct gcaaagtgga ggtattccgt gatatttcct
     8701 ttttcaccat tgatgattgg aaattcagca tctggtgaga aaccgaaatc tggtttggca
     8761 agtcctacgt gctcaaagta gtagtccatg tctgcccagc ctgattcttc gtctgttcca
     8821 acgatgaagc gaactttctt agaagttgga agacccaatt ctttgatgat tttcaaacca
     8881 tagtaacaag ctgttgtagg acccttatcg tccgaagccc cgcgcgcata aaggcgacca
     8941 tctttgatag ttggtgtgta aggatctgta tcccaaccgc taccagctgg aaccacgtcc
     9001 atatgggcaa agattccgag aacttcttct ccatcaccaa actcaaaatg tcctgcatag
     9061 ttatcaacat ttttagttgg ataaccatca cggtctgcga tttcaaggaa tttttccaag
     9121 gcttttactg gaccaggtcc aaatggatgt tgggcatcag ccttgctatc atcacgttct
     9181 gagttgattt ccaaaaggct aaacaagtca gccaagaggt cttctttgcg tttttctact
     9241 tctgctgtaa aatcaattgc tatcattttt tcttcttcct atcttttttc gatgatttca
     9301 tctactggca agcggtagct tggttccaat ttgtcgtctg tgtaacccac tgtgatcaag
     9361 agttctgggc ggaaacggtc ttcgatttcc aaaacttcat taacttttga tttgtcaaaa
     9421 ccaagaataa tgttagaacc aattccttgg tctgtcaatg caagaaccaa gttcatggca
     9481 accaaacctg cattgagagc taggtagtcg ctgacttgtt gctcactgta acgggcaaac
     9541 tcagctggca gatttttcat aaaatattga agttgctctt cagaaaagtt attagcacca
     9601 ccaacacggg caatcttacg agcacgtttg gctaagtccg tatctgtaaa caaggcaatg
     9661 gttacaggcg ctgatgatac ctgttcaaaa ttggaaccat aagctaactt tgccagttca
     9721 gcatttttct cacgtaccac cacaaatttc caaggctggc tgttgtgggc gcttggcgcc
     9781 aaggttgcaa tttcgatagc cgtacgcaca tctttgggat caacaggctt atcagtaaaa
     9841 tgcttagtcg catgacgttt tttatttaat tcaagaaatt tcataatcga tttccttttc
     9901 taattctact gcttccattc taccataatt tgaaagagct tgcagggatt tttcatgatt
     9961 aagtttttct atcacagaca taaaagatat atattggttt atcaggaaag tttctgataa
    10021 actagcaagt actttacatt tgaatggaga cagtatgaaa aaatttagcc tattactagc
    10081 tatcctacca tttttggttg cctgtgggaa tcaagctaca cccaaagaga ctagcgctca
    10141 aaagacaatc gtccttgcta cagctggcga cgtgccacca tttgactacg aagacaaggg
    10201 caatctgaca ggcttcgata tcgaagtttt aaaggcagta gatgaaaaac tcagcgacta
    10261 cgagattcaa ttccaaagaa ccgcctggga gagcatcttc ccaggacttg attctggtca
    10321 ctatcaggct gcggccaata acttgagtta cacaaaagag cgtgctgaaa aataccttta
    10381 ctcgcttcca atttccaaca atcccctcgt ccttgtcagc aacaagaaaa atcctttgac
    10441 ttctcttgac cagatcgctg gtaaaacaac acaagaggat accggaactt ctaacgctca
    10501 attcatcaat aactggaatc agaaacacac tgataatccc gctacaatta atttttctgg
    10561 tgaggatatt ggtaaacgaa tcctagacct tgctaacgga gagtttgatt tcctagtttt
    10621 tgacaaggta tccgttcaaa agattatcaa ggaccgtggt ttagacctct cagtcgttga
    10681 tttaccttct gcagatagcc ccagcaatta tatcattttc tcaagcgacc aaaaagagtt
    10741 taaagagcaa tttgataaag cgctcaaaga attctatcaa gacggaaccc ttgaaaaact
    10801 cagcaatacc tatctaggtg gttcttacct cccagatcaa tctcagttac aataacactc
    10861 ttcgaaaatc tcttcaaacc acgtcagctt tatctgcaac ctcaaagctg tgctttgagc
    10921 aacctacggc tagcttccta gtttgctctt tgattttcat tgagtataag atatactaaa
    10981 agcgatggga tcagccaatc gcttttttag tttgcattgg ttattttagg aaactcttac
    11041 aaaaaatcaa aaaaattctt cacatcctct acatacctat gcttttctat taagcttgct
    11101 aatagttcca gattgtgcct ctgatagtta tcttcacgac gtagttcttc atacatttcg
    11161 ataaagggaa gccccttgga tttggcaaat tctaactcag cctcgtaatc ataagcgact
    11221 ttacgaaata ggatatttac caattcccca tcttcaacct ctatcacggc atactgggca
    11281 cggtgatttt ttaacgcctc ccaattaaaa tagggcatgc caatcgaccc tggattgatg
    11341 atttgttgcc cttgactacc ataacgaagc aactgcttgt gaacatgacc ataaactgcc
    11401 acgtccgttt ccgcatctag cagttggtca aatttctctg tatcattctc aactagcaag
    11461 tcaccaccat agtttttgtc aggtaaatta tgagagatag aaaagcgcaa tccgtcaatt
    11521 tctttctttt ccagcaaagg caagcttcgt agccagacaa tcgttgcagg atccattcgc
    11581 tccatcaaat actgtgtcat acgcaagagc tgaacttcct gtgggtcttc taagccatat
    11641 tgcccatcta aagcctcaag gacacgatca tcccaattgc ctcgaacact tgctgtgata
    11701 ggaaggtcct ttagcagggc gactaagtca tttgcgcctg gaccaggaag aaaaatatct
    11761 cccagaagcc agtattcact gactccttga tttttagcat ctgcaatcac tgcttctagc
    11821 gccgtcacat tgccatgaat atctgataaa attgcgattt tatggtttat tgtggtttcc
    11881 ttccgtttgg taatctactc tttcttctgc tacttgaggc aaggcttctc cctgcgggtt
    11941 caactttctt tgcacagcct ctgcaacgac tctaggtacc ccaacttcga caatctcatc
    12001 cacactggct tccttgattt tggtcaaaga cttgaaatgc ttcataagat tttgcttgcg
    12061 tttaggtccc agaccatcaa tcccatccaa ttgagatgag aaagaatttt tggagcgcag
    12121 ttggcggtgg aaggtgatgg caaagcggtg cacctcatct tggatgcgtt ggaggaggaa
    12181 aaattcctga gaattgcgag acaagtccac cacttccagc ggatctccaa agagcaattc
    12241 atgggtttgg tgcttatcat tcttttgcag acctgcaatt ggaatatcca agcccagttc
    12301 ttcttggatg acttgcttag caatattgac ttgaccttgc cccccatcaa tcacaatcaa
    12361 atctggagga gtcaaagcct cacgctgtac tcgaccatag cgtctgcgaa tgacctctcg
    12421 catactggca tagtcgtctg gcccgactac ggtcttgatt ttatacttac ggtaatcctt
    12481 cttactaggc ttgccgttga caaagaccac catggctgaa acaggactag ttcccatgat
    12541 gttggagtta tcgaaggact cgatgcgaac tggggttggg atttgaagca agcgtcctag
    12601 attttcaata gctccttggg tcttctcgac agatttctct agcaggttga acttctgctc
    12661 taggctaaca cgggcatttt ttatagctaa attgaccagc tgctttttct ctccacgttg
    12721 aggcttaaga atcttggaat ccaccaaggc cttgacagcc tcttcgtcaa tatcctgcgg
    12781 aatcagtacc tcattgggaa ctaggtgaga tttttcttga tagaattgtc ccacataggt
    12841 caagaaatcc tcatctggat cattgaagta ggggaagaga ttgacatcgc gctcgatgag
    12901 cttgccctga cgaacaaaga aaacctgcac acacatccag cccttatcca catagtagcc
    12961 aaagacatcg cgattttgga gatccttagc catgacccgt tgcttggttc gaagcgttcc
    13021 aatagcctga atcaggtcac ggtattccgc cgcacgttca aactccatag tctgggctgc
    13081 cgctgccatt ttgcccttta gctcatcaat gattttgtta tcctgccctt tcagaaaatc
    13141 agaaacctcc tgggccatag acttgaaata agcctcatcc ttcttacaga tggtgtgagc
    13201 catacactgg ccgatatggt aataaaaaca gaccttagag ggcgggttgg tacacttacg
    13261 aaaagggaat atccgatcca gcaaccgctt gatttcattg gctgccccca catcgggata
    13321 aggtccaaaa taaagacctc cgtccttttt gacctgacga gtgataatca agcgtggata
    13381 gcgctcattg gtgattttga tgaaaggata ggacttgtca tccttgagca tgatattgta
    13441 cttgggcttg ttttccttga tcaggttgat ttctaggaga agtgcctcaa tattagactc
    13501 cgtaacaata aattcaaaat ccacaatttc agacaccaga gcctctgtct tggtatcatg
    13561 acttccacga aaataggacc gtactcgatt acgcagattt ttagcctttc ctacatagat
    13621 aatggtgcca tttttatcct tatgaatgta gcaaccaggg ctggtcggca agagctctag
    13681 ttttgattta atcaagttgt tcatagttcc attatagcaa aaaaagtagg gaaagatagt
    13741 accctactca ctagtctcat atatttttcg gaggtttgca acatcctctt cctggatacc
    13801 ataaaaggaa cctgctggtt gcatgacaga cttctcatct gtatggtcca agccaatcgc
    13861 atgacctaac tcatgttctg ccgtatggac aaggcgttca taggagtagc catagtatgg
    13921 attggacaaa taataatgat tcaaccgcac cgttacggac aagaattgcc ctgttaagag
    13981 attagtttga ctttccgcct ctcctgccac aggagtgcct ccgtcgttca tctccgtagc
    14041 cgtaatatcc gccttactag actcagtcac gagttcaaag ttaaaagcac cagtttgatt
    14101 ccagttctgg attgcttcta aataagcctc ttgaaagcgt gaatccatct gcggatccag
    14161 gtaaatacga gcagagacct gtggccacct tccttcagaa tgctggtgac tatctgtctg
    14221 gcttaactta ggcagttgcc ctgttttctc ccattggtca atactttgtt gaccaatttt
    14281 tactgaccgt tctgcttgct ttagcgctcc ttgaaaatcc ccgttcagat accagagaag
    14341 tccgaaagca agcacacata agagcacaac tatccaaacc agacgccaaa acaaacgcca
    14401 cacaaaagaa aagaaagccc ctatcaaacg aaaaagccag cgcatgtctc tccacctttc
    14461 tagcaaataa aaattatttt actaaaagaa gctaaaagaa atctaaatac tgactttttc
    14521 atcttaacgt cctactattt ttttgagtaa ctggatagct ttgtatttta aaggcgatgg
    14581 atggtaacgg aaagtacctg ctttgcgtac aatatagcca ttaaaattct gtttaaaacg
    14641 caaaacacca tcacttccat caaaaatccc ttgaatgcct aggaagttgt atttaggtat
    14701 tccacgtttt atgctttcca acataacata tttttgaagc agggcagggg catagaactt
    14761 attaaactca gtgtaggaac cactaaagag ataagtcgtt tcctgaggca tataaacaaa
    14821 taaactccca gctaaaacaa tatcttcttc tccatatttt tcaatcaagt ctcgcgcttc
    14881 tgcttttcga acttcaaacg tttcaaattg actagaatat tctctcagtt gattttgttt
    14941 tttctcagaa tgaggatttt tactcaaatc aagtcgcaac ttgtccaagt tttcttctag
    15001 tttactttgt tcaccttgca atttgctcat atagtccgaa aaattcaagc ttgctatgag
    15061 aaactccgct tgttctccaa aagtatcata aaaatgctca taatattcta aacttttatc
    15121 actatattct ctacgttcag aggtttcttt tgttatattc ttaaaaatcg atagttcttc
    15181 acgttttaac tttttcaacc gaatgccaaa ggtttcagcc tttttcacca agggtttacc
    15241 ctttttgcta aaacttttaa gcaaactctt ttcagttaat tcagttaaat ctttatagta
    15301 taaccaatct ggttctccac ctgggtaacc tgttattaag ccatcaaatt gataacctaa
    15361 atcagtcaaa ccttgaataa tacttttttt ctcagcatct attggattac cttggctatc
    15421 aaaagtttga taagtttcat aaggttttac aagcaactct aatacaccat tttgcttggc
    15481 atattctttt aactctgcat aaaaaactgg aagagcatct tgttgggtat aaatcggccc
    15541 cgaattgagt tccatatgca gaccacccag catgggcaag ctataaacca gagctgcaac
    15601 ttgaatttct ccttcttgtt tcaaagcaag ataaacaatt cgagcccctc ttttttctag
    15661 caaatccccc atctggacag attgcataaa ggaacgagaa gaaacctgat cagaataagt
    15721 ctgaaactct tctttcgtga gtgttgttag tgccatatac ttactttcta tgtttttttc
    15781 ttaatgtttt acggaaatca agagcaagtc ttaacagagg atagagagga tgagtgggca
    15841 ttgtaaattc acccaagtat tcttcaatcg ttggattaaa tttttcctta aaatgataaa
    15901 gtccaccatt gagagagttt tcaacaccac ctaaattttg ccagaccata cctcgctcaa
    15961 aggcatagcg agccgtttca taccatgtta aaattggtgc attgtaacgt ttaaaatcat
    16021 catccatacc agcatatata ttgacagagg tagtaccaaa ttccaaactc aaagtagccg
    16081 ctaaaggaac tctcgcttga cctacatcta tatattcctg caagaaggtc aattcctcta
    16141 acaaacgttc tttttccttc ttctgcgctt ctacttttga aattcgagtc gactcagtaa
    16201 aggtctcttc caaggctcta tttttcgcta actgttcttc taactcttgc gaacgtttag
    16261 aaacatccaa ggtggccaag gtgatatagg ccttgtcctt aaaattatct aacaattttt
    16321 tataataggc ttcattcctc aaatgaatct cttttcgctt ctcagttttt ttcatcaact
    16381 ccgaaaatga atctaatagt tccagtccac catattgaat ctcaagccct ttgtttcgtg
    16441 ctgttcgaat agcctgtttt gttgacttgg aaagtttatc ttcttcaaaa ttttccttgt
    16501 atattttcgc ctgaatacga ggttgaatgg tgtctcccat ttcctccgtt tttcctgacc
    16561 accttactcc catttgttgc aaactatcaa taatagccag attttcagga aattctgtct
    16621 tttcctgatt gattaaactt tgagataggc aaatacttgg gtcaaaagtc acaaaaaccg
    16681 ctctcttact gcgagcatag gacttaatag actgaatggc aaaattcaag agttctttat
    16741 ccccataatc caatataggt cctcttggga tgtaaaacat tttatagcct agcggaagag
    16801 ttctaatcaa aatactagct gtcgccagta atttttcttc cctgtaaaca ccaaacttct
    16861 catgttgcca attagactta acttcctccc aagcactact ttgtaataca ttggctaatt
    16921 catgttcttt gacaaactga tcatattcta atgtgggaat gccaatttga taacggtaca
    16981 tttcctactc tctttcctcc agtattttat tactattcta ctactttcgt ttgaaaagtc
    17041 tagtgaaaac atattttatt ttagttctac ttcccctatg ctgaagttca aactaagtca
    17101 gtctctcttc taatttgaaa tcaattggta gggttgttaa aaaaacttcc aattgttttt
    17161 cccagtagta ccactcgtga gttccagcgc tatggctata ggtcacatca aaacctagtt
    17221 ttttgagatt tttcactgca agattattgg cttcgtacaa gaaatcctgt tcgccacacc
    17281 acgcccaaag tttggtcttt ttatccgatt ttttagccag actttcaaga gaatagggac
    17341 tagttgtcca gtctttaatc tctccaaaaa cacctctcca gtaggctggc gttcccagat
    17401 tttgactctc aggagaaaaa tcttgaaagc tcaatgcacc tgaaaagcta gctgcatgag
    17461 aaaaacgatt tgtcgcaaga gccagtttga aacagccgta gcctcccata gaaagaccag
    17521 cgataaaggt cttttcacgc ttgctagtca tattagggaa gaagcgtttc agaacctgtg
    17581 gcaattcctc tgctagagcc gtgtagtagt caaaaccata ctgggtatcg gtgtaccaac
    17641 cattgctggt attgggcata acaacgatga gattagttcc tcgaagcaag cgttctacat
    17701 tggtccgctt aagccaacta ttatgattgc cagacatccc gtgcaaaagg tacaagacgg
    17761 gaatatcttc acactctggt tcttccactc gattggcatc agggtagagg acattcaccc
    17821 cccactccat atccaatact tgtgagtaat actcgatttt cattactgcc atgattttct
    17881 ccttctattt ttctataaga aaaagccgaa actcgacttt ctctctgttt attttaacga
    17941 ttattttgct tccatgacta ctggtaaaat ggctgggcga cgcttggttt ggtcaaagag
    18001 atacttggtc aaattatctc gaaccttccc tttaagatct gcccagtcaa agtcatctcc
    18061 ttgaagatac tcttctaccg tttggttaat caattctgaa ctttcacgga gaatatcgcg
    18121 actcttcttg agataaacaa atccacgcgt gtgaacacga gccctagcca caattttctt
    18181 ctcacgacgg ttgactgtaa tagccacgat gaaaattcca tcctctgaca agaccttacg
    18241 gtcacgaaga acaacatttc caacatcacc aatggcattc ccatcaatca agatatctcc
    18301 tgctgaaacc gatccagctg gaacaaagtc tccattctcg taagccatgg tcgtcccctt
    18361 tttaggaatg aagatgcgtt ctggcaacat cccaactgcc atggcagcct tagcgtgagc
    18421 atccaactca cgatactccc cttggacagg gaagaggtac ttaggttgca aaagattgat
    18481 catcagctgc aaatcacgca catttccgtg ccctgataca tgtaaacttt gggtaatcaa
    18541 tttgacaacc ccacctgcct gataaatcat attttccaca cgcgcaacaa aggcttcttt
    18601 agcaatagac ggagccgtag caatatagac caggtcccca tccttgattt ctacataacg
    18661 atggcgacca atcgacatct tacgaagtcc attgataggt tcacccatac gacctgtctc
    18721 aagaataatc aactcatggt cttcaaatcg agacatatct ttaggcttaa tcaagagaat
    18781 ttcgttggct aaagacaact tcttaagacg aatcgctgtg cggacgatat tttcaatatc
    18841 aaatcctgtc aagacgatac gtcgacctgt tttatccgca gcgtcaaaaa tctgctgaat
    18901 acgagaaaga ttactggaaa cagctgcaac gatgatacga ccttcccagt cagcaatagt
    18961 ttgggtaatt tcatccctaa cttcactttc actagccacc tgaatattgc tgtctgcatt
    19021 ggccgaatca ctgaggagag ccaggacgcc gtcacgacca atctctgcca aacgagcaaa
    19081 atcagttgca taagattcac tagccgtttg gtcaaatttg aagtcacctg tataaacgat
    19141 gcttccttcc gatgtcttca agacaattcc cagactctct ggaacggagt aagtcgtagg
    19201 gaagaaggaa accactgtcc caccaaaatc aatctccgta ttctcatcaa tgacatggaa
    19261 atcattaaat ttcttaacgg catcatttcc tttgacaaag agctttgcca actcaatggt
    19321 caactcagac ccaaatacag gaactttagc ctctgccaag agatacggta gagcaccaat
    19381 ggcatccgca tgcccgtggg tcaagaaaac cccagcaata cggtcgctat tttcaaaaag
    19441 gtaatccatg tttggaatca ccacatcgac ccctaattgt tcattttcag gatattttaa
    19501 ccctacattc aaaacaaaaa tggactctcc aatttcagca atgtacatat tttttccatt
    19561 ctcacgcaca ccaccaagtg ttgttaaact gatattactc atttttcctc caaaatctta
    19621 gtttatcttg attatagggc aattctaccc tcttattcta aaagttctga tactttcagc
    19681 cgaatctttt cctaccatta taccattttt ttgatgattt tcaaaatgaa ggtctgtttt
    19741 caaaaaagag ttgatttccc aactctttcc taacttctac tctttttcca tcaaaaaatc
    19801 ataaatttct tgcaccgtac ccagcgccat catttcttgg tctttaacgg tttgtttgag
    19861 attttggtaa atttgacttt ctcctatctc ccgctttggc gcctctttat tgactgtcat
    19921 cacaccatct tttatcgtca caaagcctag ttcttcaaat acttgaatca tcttgaccag
    19981 caagatttgt tgaatattaa gatatgcagc caaatctttc agcttgtagc gaatatcaaa
    20041 ctctgggaac tggtaaatag tcttgtacaa tttggcaaac tgatctctag tcccataacc
    20101 tgtcagataa taagccttgt caatatcatt tttgaaatag acagcagaga aatgctgttc
    20161 ctgaaaaatg gtcttcagct gagtaatatc ctctggaatg ttttttacga caacagcttc
    20221 actagccgca agatttggca gttctccagg aaaatccaag actggaacac cttctggcaa
    20281 gactgcattt tttccacgaa tgttaaaaag ttgaacacct tccactcgcg catccaccat
    20341 catcaactgg agggcagttt ggccattcca ttggttgaca gacaatttaa ccgctaactc
    20401 tagattcttg gtttgagaaa actctgtcgc ccatctgcct tgaccaaagg ctaccacttc
    20461 aaaactcgcc tcacccttgg aaattttcag ctttagatgg gcattacctg cccccatagt
    20521 acgagcactt tcgacctgaa aattcttgat ataaaaaata ggtttctgat tatccattcc
    20581 aaaaggagct aaacgttcaa aacttttgac cgtttccaag ctaagtgcct ccaaatccaa
    20641 ctcttcatct aggtttaact tattcttgcc accagcatct gcaccttttt cacgaacata
    20701 atcttccaaa acctgagata aatctgagag ttgctcaact tccaacgtca tacccgctgc
    20761 acctgcatga cctccaaagg cgatgaagag gtctcgatgg ggatccagag cttcaaaaat
    20821 atcgaccgct tccacactac gagcactgcc cttggcacga ccgtcttcta tattaagaac
    20881 aatgactgtc tgtcccaatt cttccaataa acgaccagcc acgattccta gaaccccagg
    20941 attccagcct tccttggcca agacctgaac cttcttctca ggatccacca tggtcttggc
    21001 ttcttcatag atagactgaa cgatttcctt gcgctcttcg tttttctggt gaatcataag
    21061 ggcaatctca tgcgcttcct catcatcaaa tccagtcaac aaatcaatgg caggattggg
    21121 atcatccaag cgacccaagg cattcaaacg aggagcaatc tggaaaccaa ccgtttcttc
    21181 tgttacttcg ttggcaccaa tcccagccat gtccagcatt tcttgcagac caatgcgctg
    21241 ggtatgaccc aacatttcca gaccatattg aactaagata cgattttcat ccgtcagact
    21301 caccatatct gcaatagttc caatagcgac caaatcaagc aattccactt gcacttcttc
    21361 taacagggca caagccaact tgaaagcaac tccacaacca gccaaatatt taaaaggata
    21421 atccgcatct ggatgttcag gatggacaat agcataagca tctggcaggg tttcaggcat
    21481 ggaatgatgg tctgtgacaa tgacatctac tcccatagac tgagccaatg caatagcctc
    21541 atgaccagca accccattgt ccaccgtcac aatcaaggaa atcccttctt gctcgataaa
    21601 gtatttataa acactagcat tagggccata gccatcggta aaacgatttg gcaggtaaac
    21661 tcggcactca gcaccaagtt gttccaaact ttccttcaca atagaagccg aagtcatgcc
    21721 atccgcatca tagtctccat aaacgagaat attttcccct tcttcaatag cctgacgaat
    21781 ccgctccact gccttgtcca tatcatggag cagataagca tcatgtaagt cctccaagga
    21841 aggttctaaa aacttcttca gactttcttg gtcctgaatc cctctctcaa acaataaccg
    21901 agccacctca ggacccagtc cagccttctt ggctatcttt gtaaaatccg catcttctac
    21961 ctgcagggca aactgccatt cataagtagg tgttatcaaa aagacatcca ctctttctaa
    22021 gaattctatt gcttcattat aacatgattt agacgttttc tctatccaga ttgctttttt
    22081 ataacatttt atagtatatt gaaactagaa tagtacacct ctacttctaa aatattgtta
    22141 gaaatcgatt tgactgtccc gatcgatttg tcctgttctt atttcactat agtgaatttt
    22201 ttcagatatg gtttgacaag aacattcttt tattgtagaa tcgtgttata aaatctaaca
    22261 taaaggagat ctctcatggc tttagtagaa tttaaaaacg tcgaaaaata ttacggagac
    22321 taccacgcac tccgcaacat caatctccgt tttgaaaaag gacaagttgt tgtcctgctt
    22381 ggaccttctg gctctgggaa gtccactctt atccgtacga tcaatggttt agaggctgtt
    22441 gacaaaggaa gtctcctagt caatgggcac caagttgctg gtgccagcca gaaagatttg
    22501 gtacctcttc gcaaggaagt cggcatggtt tttcaacatt ttaaccttta tacacacaaa
    22561 actgtgttag aaaacgtgac acttgcgccc gttaaagttc taggaattga taaaaaagaa
    22621 gctgaaaaaa ccgcccaaaa atatctggaa tttgtaaata tgtgggacaa gaaagattcc
    22681 tatcccgcca tgctatctgg tggacaaaaa cagcggatcg ccatcgctcg tggtcttgct
    22741 atgcatccgg aactcctcct ctttgatgaa ccaacatctg ctcttgatcc tgagactatc
    22801 ggagatgttc tagcagttat gcagaaactg gcgcatgatg ggatgaacat gatcatcgtt
    22861 acccacgaaa tgggctttgc tcgagaggtt gcggaccgca ttatctttat ggccgacgga
    22921 gaagtgttag tagatacgac agatgtcgat aacttttttg acaatccaag cgaacctcgt
    22981 gcccaacaat tcctcagcaa aattatcaac cacgaaagtg acaaagtcaa ataaggaggc
    23041 gcctatgaaa aaaaaattct ttttatcagc attattgatt agccttttcg gccttgctgc
    23101 tgccaaacca gtccaggctg atactagtat cgcagacatt caaaaaagag gcgaactggt
    23161 tgtcggtgtc aaacaagacg ttcccaattt tggttacaaa gatcccaaga ccggtactta
    23221 ttctggtatc gaaaccgact tggccaagat ggtagctgat gaactcaagg tcaagattcg
    23281 ctatgtgccg gttacagcac aaacccgcgg cccccttcta gacaatgaac aggtcgatat
    23341 ggatatcgcg acctttacca tcacggacga acgcaaaaaa ctctacaact ttaccagtcc
    23401 ctactacaca gacgcttctg gatttttggt caataaatct gccaaaatca aaaagattga
    23461 ggacctaaac ggcaaaacca tcggagtcgc ccaaggctcc atcacccaac gcctgattac
    23521 tgaactgggt aaaaagaaag gtctgaagtt taaattcgtc gaacttggtt cctacccaga
    23581 attgatcact tcccttcacg ctcatcgtat cgatgccttt tccgttgacc gctctattct
    23641 atctggctac actagtaaac ggacagcact actagatgat agtttcaagc catctgacta
    23701 cggtattgtt accaagaaat caaatacaga gttcaacgac tatcttgata acttggttac
    23761 taaatggagc aaggatggta gtttgcagaa actttatgac cgttacaagc tcaaaccatc
    23821 tagtcatacc gcagattaag gaggataccc tatgacagat ttatcatctt ggacagccta
    23881 ttttcaggat tttggacaat ttttcaatgg tttcctcttt actcttgccc tagcgattgg
    23941 atcctttatc ctcgccatgg tcttaggaat cttctttggt gccatgtcaa ccagtaaacg
    24001 tccgattttg cgaatcttag ctcgcatctt cgttgaattt taccaaaata ctcccctctt
    24061 ggtgcagttt gttattgttt tttatggcct acctcttatc agtgaccata ctatcatgat
    24121 tccgatttat tggacagctg ttctctgcgt gggactctat cacggcgctt atatcgctga
    24181 ggttattcgt tcagggattc agtctattcc tagtggtcag atggaggccg ccttgtcgca
    24241 aggttttacc tatatcagtg ccatgcgctt gattatcttg cctcaggcct tccgcatcat
    24301 tctccctcca ttgaccaacc aaattgttaa cctcatcaag aacacctcta ctgtagctat
    24361 catctctgga gtagacttga tgtttgtgac taagtcttgg tcggctctca acggaaacta
    24421 tatcccaggc tttttaggtg ctgctcttct ctactttgcc ctatgcttcc ctgttgccca
    24481 gtttggtcgc aagatggagc aagtcaacaa aaaagcctat tcactttagg aggttactat
    24541 ggaatctatt ttagaagttt taaccccaga taacctagtc tttatcttta aaggatttgg
    24601 cttgaccctc tatatttctc tgattgccat catcctctct actatcatcg gtaccgtgct
    24661 tgccgtcatg cgaaatggaa aaaatcctat cttacgcatt atttccagta tttatatcga
    24721 gtttgtgcgc aacgttccca accttctctg gatttttact atctttttgg tgttcaaaat
    24781 gaagtccaca ccagcaggta ttacagcctt tactctcttt acatcagcag ccttggctga
    24841 gattattcga ggcggtctca atgccgtaga caagggacaa tacgaagcag gaatgtcaca
    24901 aggcttcacc tcagcccaaa tcctctacta catcattctc ccacaagcca tccgcaaaat
    24961 gctaccagcc atcatttctc agtttgttac cgtgattaag gataccagtc tcctctactc
    25021 tgttatcgcc ctacaagaac tctttggagc cagccaaatt ctcatgggcc gttatttcga
    25081 accagagcag gtcttcagtc tttacatcct gattgccctc atctacttca gctttaacct
    25141 agcaatttct aacctgtctc atatgctagc aaaacgttgg caacaagctg cagaataaca
    25201 aattagctct ctagttcatt ggagagtttt ttgatgatag tagatattta tagacctcaa
    25261 tttgacacca tacattttct atgataaaat gtaacaaatt tatttacaac aaatcgaaat
    25321 ctaaatgaaa tggaattttc tatgaaatca atcaaaggac tactctttat catagctagt
    25381 tttatcttga ctcttttgac ttggatgaac acttctcccc aattcatgat tccaggacta
    25441 gctttaacaa gcctatctct gacttttatc ctagccactc gtctcccact actagaaagc
    25501 tggtttcacg gtttggagaa ggtctacacc gtccacaaat tcacagcctt tctctcaatc
    25561 atcctactaa tctttcataa ctttagtatg ggcggtttgt ggggctctcg cttagctgct
    25621 cagtttggca atcttgccat ctatatcttt gccagcatca tccttgtcgc ctatttaggc
    25681 aaatacatcc aatacgaagc ttggcgatgg attcaccgcc tggtttacct agcctatatt
    25741 ttaggactct ttcacatcta catgataatg ggcaatcgtc tccttacatt taatcttcta
    25801 agttttcttg ttggtagcta tgccctttta ggcttactag ctggttttta tatcattttt
    25861 ctatatcaaa agatttcctt cccctatcta gggaaaatta cccatctcaa acgcttaaat
    25921 cacgatacta gagaaattca aatccatctt agcagacctt tcaactatca atcaggacaa
    25981 tttgcctttc taaagatttt ccaagaaggc tttgaaagtg ctccgcatcc cttttctatc
    26041 tcaggaggtc atggtcaaac tctttacttt actgttaaaa attcaggcga ccataccaag
    26101 aatatctatg ataatcttca agccggcagc aaagtaaccc tagacagagc ttacggacac
    26161 atgatcatag aagaaggacg agaaaatcag gtttggattg ctggaggtat tgggattacc
    26221 cccttcatct cttacatccg tgaacatcct attttagata aacaggttca cttctactat
    26281 agcttccgtg gagatgaaaa tgcagtctac ctagatttac tccgtaacta tgctcagaaa
    26341 aatcctaatt ttgaactcca tctaatcgac agtacgaaag acggctatct taattttgaa
    26401 caaaaagaag tgcccgaaca tgcaaccgtc tatatgtgtg gtcctatttc tatgatgaag
    26461 gcacttgcca aacagattaa gaaacaaaat ccaaaaacag agcttattta cgaaggattc
    26521 aagttcaaat aagtaatcat actctcctgg gatttcccag gagagttttt tatagccaaa
    26581 tgaaataaga ccggaacgat ggaattttgg cattcaaatc aattgataag aatattttat
    26641 agtggagtga aataggatac gaacaaattg attaggaaaa tcaaatgaat ttatagaaat
    26701 cttttagcag ttatgttgtc ctattctagt ttcaaaacgc tatggaagca gcattgtgct
    26761 agtctagatt cagtttacta tactaaaacg agtagcttga aatcaaaaaa cccaccctca
    26821 caggcaggtt ttatctgtat tattcagcta gattatgctt taccttctga accgaatacg
    26881 tcgatacgtt cttcaaccga tgcttggata gcttttacac cgtcagccaa gaatttacgt
    26941 gggtcgaaga gttttttctt gtcgtattct gcttcgtttg cttcgtaatc acgagcaaat
    27001 ttacgagttg cgttagcgaa tgcgatttgg cattctgtgt taacgttaac tttggcaaca
    27061 ccaagtttga tagctgcttg gatttgctca tcaggaatac ctgatccacc gtgcaatacg
    27121 attgggaatc ctggaagagc ttctgtcaat ttttgcaagt ggtcaaggtc aagaccttcc
    27181 cagtttactg ggtaagggcc gtggatgtta ccgataccag ctgccaagaa gtcgatacca
    27241 gtttcaacca ttgctttagc gtcttcgatt ggagccaatt cacctttacc gatgattccg
    27301 tcttcttcac caccgatagt accaacttca gcttctactg agataccttt agcgtgtgct
    27361 ttttcaacaa cttctttagc caatttaagg ttttcttcaa ctggaaggtg tgaaccgtca
    27421 aacatgattg aagtataacc aacttcgata cactcaagtg catcttcgta gtgaccgtgg
    27481 tcaaggtgga tagctactgg tacagtgata cccattgatt caacaaggtt agcgatcaag
    27541 ttgcgagcaa ctttgtaacc acccatgtat ttagcagcac ccattgaagt ttggatcaaa
    27601 actggagctt ttttagcttc tgctgcgcgc aagatagctt gagtccactc aaggttgttt
    27661 gtgttaaatc caccaactgc ataaccgttg tcacgggctg cttggacaaa tttttctgct
    27721 gaaacgattg ccattttatc aggcctcctg tatattttta tgggtcatcc catttacatt
    27781 gttcatttta tcactttttg ccaaaaaaat ctagtttttc ccgcagtttc gattgatttt
    27841 cttctaactc catctatgta aaccctttct ctccctagtc ttggacgact tttggaaaag
    27901 ctataaagaa ggttaaacga ttctcctcca tctcgaaacg ataagctaat ttttcatgtt
    27961 ctaatagact cttaaccaca aaaagcccca taccagaccc cttgaccttg cgactggcat
    28021 tgtcagaaaa agactgggct agtttttctt gttcctctga gctacagcta ttttcgataa
    28081 aaagttctcc ttctctttct ccaattcgaa ctaagccacc tggaacagag tgcttaatgg
    28141 cattgctgat gagattagaa agaatcaact tcataactga tgggtttaga taagcctgct
    28201 gatgggtcaa actattgtct atctggagct ctctttcctt ggctagcaag gcataatctt
    28261 tgaccagatt tttcgtcatc tggaggaggt caattgtttc cctatcatct cgcaattcct
    28321 gcacagaaga gagggaaagt atctgcagaa catggtgatt gagttcatcc acaatcccca
    28381 aggcaactcc cagatactgg tctctatcct tataacgacc gatattctct ctcatatttt
    28441 cgattaggat tttcaaacta gccagcggtg ttttcaattc atgagaagct cctcgtagga
    28501 attcgacctt catcttctcc agctggagaa tggcttcatt cttttcatgc aagtccgcaa
    28561 taacagtcaa gagatgctgg tagaggctat tgatttgttc cttgagatta cctatctcat
    28621 ccttagaatc cacgcgcaat cgcacttggg aatccaggtc catcatccga cgggtcaccc
    28681 gcttgatttc caaaatcggt gcaacaatag tccgagcgta gatgtaggcc accaagaggg
    28741 aaatcagaaa ggaggccagc aaggtatagg gaagaaactg gagactgatt tgctccgctt
    28801 ccttttgtaa atccatggaa gctagaaact ggagaatcat agtaccaccg tcttgcgttt
    28861 tcacctcgcg ctcctcaata aagagagagg ttgtctggcg gtctgtgtcc agaggaagac
    28921 tgtccttgac ttctaacttg tcctcggtca tctcaccttt gacggtcccc ttgatatcac
    28981 tagtctggga atacaagtct aacacttgct cgatactctg cctatctttc ccttctaggg
    29041 actgggcaat ggctgttgcc ttttgaccaa tggtttcctg acgatgactc agataagtcg
    29101 aaggaaaaag aaaataaata gctaaatgaa ggcagataac cagaacacta aatatcgaga
    29161 aggtatagat aaatatcttt gtaaataaac ctgttcgttt cattttcgct ccaatttata
    29221 accaacattg cgcacagtga agatacaatc caagtctagc tttttccgca attccttgat
    29281 ataaacatca ataacacggt caaagggaac ctcatctgtc gctttccaga cggcatcgat
    29341 aatctgagac cgagtcaagg cccggccttc atttttcact agatagtcca gaatttccaa
    29401 ctctttggca ttgataggca cttcttgacc tgcgaggctt gcactgtagc tttcaaagtc
    29461 caccttggta tccttgtaag aaaagattcg tcctgtatcg tagtagcgct tgaaaatcgc
    29521 gtccaccctc acttttaaga gggagaggga gaaaggtttt tccagatagc catctgccaa
    29581 agaggcaaag gcactcatct tgtattcctc atcctgaaaa gctgtcaaca tcaagacagg
    29641 aacctgactg gttttacgaa tctcagctag gacttctaag ccgttaagct tgggcatctg
    29701 gatatccagt aaaaccaggg ccacctcata gctagaaaat tgctccagag cttcctgacc
    29761 gtccgctgcc tcaatagttt catagccaca atccgtcaaa taatcactga ccccctcacg
    29821 gatcatctct tcatcttcta caattaaaat tttcatactt taactgctct ctatttttta
    29881 tttttcttag aataaatacc tactctattt tctattatag tctcttgctg gccttttgtc
    29941 tgtaagcaac tgaccactag ataaaacgtt gtgaaattcc tttctcataa attccataac
    30001 tttagtatat tatatttaag cactaaagta caaagaaagc aactgaaagc aatgattttc
    30061 accactgctt tcgatttatt ttgaattgtt aaatagctat tcctatccac tattcttgaa
    30121 tagaaacaca agatgcaatc tttattccag actcattttt tcaaatttat tcaccatcca
    30181 gcaagagctc ttttggttgt tttctaagga gattgcttga agcaagcgcc ataacgagaa
    30241 ccactagaac caaggcaagg acaaaaatga tgataaagtc tgatgtctga atggaaatgt
    30301 ctaggctcga caaggtcttg ctaaagccat ctacttctgc accgccacca aggttagagg
    30361 cttgagccgc cttactagcc tgtttggcaa cacctgaagt cacattggca aggacagtgt
    30421 ttccaattgc acgggcagtg taattagcta gaaagtaagc agaaactaga gcagggatag
    30481 caatcaagat agattcggtt atgaattgac ccaagatact tgcctgcttg aggccgatag
    30541 agaggagaat tcccacttcc ttgcgacggg cgttgatcca aaggctgagc aagagggcaa
    30601 ggaggagaac tgagaagctc aagctacccc agaagaggag gttggccatc ttgtacatac
    30661 cagagataga ttgctcaaga gctgggtagt tagaggagct cttgacgagt gtgtagctct
    30721 tccagttgat accactgatg ccattcaact ctttcataac atcatccaag ttcttgtctg
    30781 ctgttacaaa gaaggttgcg tccccataaa tggctgtgtc ttctgtgtat ccataaagtt
    30841 ttgcagcagt gtgaatgtct gtaatagctg tgttttcgta aagttcttgt gagtaggtta
    30901 ctgctgactt attatgacca tcaaagagtc ccttgattgt cacttcaact gtttccttgg
    30961 ctcctttttc attatctgca tcgtagatat tagagtccag tttaaccttg tcccctactt
    31021 tccagccgtg tttggctgcc aagtccttgt gcaagaggat tttatccttg tcgtcgttgg
    31081 ttaagtgctc tccttcgact agtttataag aaccagagac aaacttgtct tctttagagg
    31141 agtcattgac acctgtaatc atcaagctac ttccaaaacg tttggcacga tcagcagtga
    31201 gattcttctt ggtttctggc gtttcaatca ggtcatatcc agtcaaatct ccgatagcgt
    31261 tgatacgttt gacataagac tcaatggcct tgttttcggt gatttttttg atgtcttcac
    31321 ccttgatatt cccagcacca cgaggcgttc cttggttgac gcgacgattg atttgcatgg
    31381 agaagctatt ggtgatattt ttaaaggtct cctgagaagc cttggcagta gctcccttga
    31441 ttgacaagcc gaccaaactc aagctcgcca taaggagaat aatcaggaag atgacaatcg
    31501 atttgaaaaa cttccttgta acataggcaa atgcgttgtg taacatagat tccctttcta
    31561 gattttgttt taatcattct attaaaataa gctcaaatta tttactagta ttgcgcgttt
    31621 cagtcagttt cttatccttt aattcaagtg taatatctga cgcttgtgcc acttctttac
    31681 tgtgagttac gacaatcaca catttacctg ttttctgggc aagtgatttg agtagttcga
    31741 caatatctcc agcagtttta ggatccagat ttcctgttgg ctcatcagct agaataactg
    31801 gagcttctga gaccaaactg cgagcaatgg caacacgttg ctgttgacca cctgataact
    31861 ggagaacatt ccgcttgatc tggctttcat ccaaaccaag ctcaagaagt gtatccttgc
    31921 ttgccttttt gttgaccaag cggatatttt ccagcggaga aagataatct atcaagttat
    31981 aattttgaaa gaccagggaa atatggtgca tgcgatggta agaatagccc ttcttacgaa
    32041 tatcctctcc ttgaaaaagg atagaacctt caacaggact atctagacca gcaagtaggg
    32101 acaagagtgt ggattttcct gctcctgact ccccaataat actgtaaaat tttccgggtt
    32161 caaaattata atcgatctga tataggactg cttcagcagt attcttataa cggtaggtaa
    32221 catcttgtaa ttgtaataaa gtcatgattt ctccttctta actaatagat gataaaattt
    32281 ctttcggtga ttttctaaat aagaatagga aacaaagggc tacagataag caactaagca
    32341 gaactagaaa aacataggat tctgcaaaag ataagatgct agttgataaa ctgcttgctt
    32401 tggctagtgt atcttgtaag cttgcctgat ctccacttgc tagtagagtt tggagtaggt
    32461 aagttgtgat tccgtttcct gcaacaaatg ctggaagcaa agctccaaga gataccaaaa
    32521 ctacctctaa acagaattgt aggaagatcg agctcttgcc ttttccaagt gcaagtaaaa
    32581 tccccacttc atagacccgt tctctcaacc agagagacaa aaccagaatt aaggctccag
    32641 ctcctgctat caacatccca taaaggaaga tggtcaggaa ggtttggaaa gttgcaactg
    32701 agtctttgat ttgttcaaaa gccttgtttt ccttttcgac ttggtagcct tgattttcca
    32761 aggccaagtt ttctacctgc ttcatgagtc cgtccatttc cttaggattt tctacataga
    32821 agcgtgctgc actgacttga gcttcactat tgcccaaaag ggtttggcta ctgtcatagt
    32881 ctgtaaagac ttgattttca ctgaagtcag aagacaagcc tgtgaatttc tcttgttttt
    32941 taccagaaaa gatgccgata atctcaaact ctactgtttg tccttttcca gattcagact
    33001 gaccagcatc caagccaatc ttgtcatgaa gcgaaagacc gttcttctta gccaattctt
    33061 cgtggataag gattttcttg gaatcccctt tttgaaggtg tcgcccttct tttagattga
    33121 aagccgaact ggtaaaggtt acatccttgg atgaatcctc aagagccgtt aagctaacca
    33181 agttattgtc tgcagctgat aaatcatcac gctccacgct ctgctcgcca gtcactgctt
    33241 ccttgtcttt tagttttgcg accgtctcaa gttcaggaga gacattttcc agccccttaa
    33301 tcttgcttac agatgctagg tctgacaact tgaatgtctg accattctct atcttcttaa
    33361 tagaaaaaga tgtattgagt gatttataaa gattgctttc tactgttttg ttggacttca
    33421 tcagagtcaa acaggctgaa attccggcca ataagaccaa taaaatcaga aataaaataa
    33481 aacttctcag tcgctttctg ctgacataag cccaagatct ttggattgga ttcatttgtc
    33541 acctccatat ttgtaagact attataaaac ccaaatatga aatgtttatg aaatacgaaa
    33601 aaaaaatatc gagtagggga taatctctag cccctctcac accaccatac gtgccgttcg
    33661 gcatacggcg gttcaactaa cttttaacgc atgtcgttca aggtaataat ccaaacacga
    33721 aaccagtcca cgtttttcaa ggactggttt tgatatagca cgtttaagta ctgacttctg
    33781 agctactata gtagattgaa actagaatag tacacctcta cttctaaaat attgttagaa
    33841 atcgatttga cttccctgat tgattcgtcc tattcttatt tcattttaat ataattgata
    33901 gtggtcgccc cagccagata ccttatctgc tatccattta ggaaccccta acttaagcaa
    33961 tccccataat cgtctcgatt tcttcttcca ttgcttccag ataatcactc gtaggcgagt
    34021 acgcaagcgc tcatctatgc tagtgactat acttttcata tttataattc attcctttcg
    34081 tttcactcaa ggcacaacac agaatgaaaa agtgttgtga tctttatttt gttttataat
    34141 aatagtgaga aagcctatca ctactacaaa tcacggggag gtgaataagt gagtggtaca
    34201 gccactacct cgcatatttt gtcacatcat ttaacggtac ataataagtt gtaccatctg
    34261 aataagttgc tacaatatca tttgcatgct ctccttcacc tttagcaaag gttggagctc
    34321 ctgctggatg atttttattt gcctctttca atttttcaat aatggcattt ttttctgtat
    34381 cttttatatt atcaggattt ttcactaaga ttttgtctgg atatgtcggt ttagcagaaa
    34441 caatttttac tgttacttct tttttattcg aagcacttgt ccagtttcca gcattatctt
    34501 tagcatttaa ttttacagta attcctgaac taggaacttc agtagcaggt tgattatcaa
    34561 cattattcaa ctttaatttc aaaagagctg ttgcatcaga cgttttatca atcgttatat
    34621 ataatgatga attgttatta taaccagttc cttcatattt agctgtttgt gagctacttg
    34681 aaacagaact gaaattatac ccactacctc cctgattatc ttcaatgctt acgtctaaat
    34741 gaacttcccc actattattt ggcttagcaa caactgttat agtaaaataa cataaaattt
    34801 gcataaatag attagggaaa tcaaagcagc ttctaggaat gttttagcag tcacagtgta
    34861 ctttcccagc atcaagccac tataactctg cacataaaaa tggagaagat ggcaatcctc
    34921 ttctccaaat attaacttct ttacaaacca actatagttg acaaagaacc taaaatcaat
    34981 tgataacaca aggtcaggtc ggtcaactct ttcaactgaa gccctgtcaa ctcttcccat
    35041 ttatcaatct tgtattggag agaattgcgg tgcagataga gttgctgggc tgttttagtg
    35101 agaacagcac tattttccca aagagagaga atgatttcct gaatctgatc ttgatccaaa
    35161 atcatctggt gtagacattc tttaattggc ttcaagtcca cgagtctttc tcccatactc
    35221 caaagataga gctgagaaaa agtatgaaca ccttggtgac cctgacgcca ccatgtcttg
    35281 aacaaatccc gctcagcttt gattaagtct gatagggctt gatgtcctgt ctgagaccaa
    35341 acctgaccca acatgataga aagacgaagt ccaaaatcat actcaaccgc ttcaatcgta
    35401 tcacttaaaa tatctcttac agaagtgtat ttgtcttgtt gaagcacgaa aacataatcc
    35461 tgagctccga cctgtagcac tgtctgacaa ttcggaaaaa gagtccgcat catatctagc
    35521 caagaagtca gattttcctg ctgaaaataa gaaagatggc aataaaccaa ctgaatcttt
    35581 ttaaaaactt gcggtgcctg tcccttgcct tcaaccagat aggaatacca agggtttagc
    35641 gaacgagcct gctcctgctg ggtcaaaagg gcaaccaact gcttttcacg ctcgctgagc
    35701 ccagcttcct ccagcaaaat ccactgctga gaagctaaag ggagcgtgag atagccctct
    35761 ttctctactg gttggtctga aatccgagcc tcaggaaacc agtcttgtag ttctttttcc
    35821 ctcatgttct agccctccac tttttggatg caccatgaaa ccaaactctc aagacgttcc
    35881 agattctcag tcatatggag atagcccata accgcttcaa atcccgtgga catacgataa
    35941 gtcacgacat ctgcattttt agcctttgtg tggctattgg tattgcggcc acgtttgtag
    36001 atttcttctt ctttttccgt taggacctgc tcctccaaca tgagagcaat caggcgagcc
    36061 tgagccttgg ctgacacata cttggttgct tcttgatgga gtttattggg tttggtcata
    36121 cctttgagga tgaggtgacg gcgaatatac atagaataca ccgcatcccc ctcaaaggct
    36181 agcgcaatcc cgttaatgag attgacatca atcacgtgtc cacctcactc catccttggt
    36241 atcaaggagc ttaattcctt gagtaaccaa ttggtcacgg atttggtctg ctgtcgcaaa
    36301 gtcacgattg gcacgcgcct cttggcgttt ttgaatcaag tcttcaatct ctgcatccaa
    36361 aacttcctca acaaagacaa ttccaaaaat ttctaacata tctgcaagag cttgcttgac
    36421 acttgcatca tagttccctg agttgatcca tttggccatt tcaaagacaa ctgtgatacc
    36481 gttggcagca ttaaaatctt catccatagc tgctacaaac ttatctttaa agttttgtaa
    36541 ctcttgggca tccacgtttc ctgtaaatgg ttgttcgtaa gtattcttca gatacttgag
    36601 attggtctcg gcatcgcgaa ctgccttttc cgtgaagttg ataggcttac ggtagtgctg
    36661 ggtcgcaaag aagaaacgaa gtacttgccc atcaagagtt ttaagggcat cgtgtaccgt
    36721 aatgaagtta cccaaggact tagacatttt gacattgtcg atattgacaa agccattgtg
    36781 catccagtag ttagcaaaag ccttgcctgt tttagcttca gattgggcaa tttcattggt
    36841 gtggtgtgga aactctaggt cagctccacc accgtggata tcaatggtat cacctaaaat
    36901 ctctgtcgac atgactgaac actcaatatg ccaacccgga cgtccaggtc cccaaggact
    36961 atcccaagaa atctcacctg gtttggaaga tttccataga gcaaagtcta caggattttc
    37021 cttacgagcc gtttcttcat cggtacgacc tgaagcacct agctccaaat cttccaaggt
    37081 tttattagcc aatttagcat agttgtggga tttttctaca cggaaataga catccccttg
    37141 actctcatag gcaaagcctt tctcgatcaa gtcttccaca aaacggatga tgtctgccat
    37201 aaactccact acacgcggat ggcgagtcgc aggtttcacg cccaaggccg tcacatcctc
    37261 acgaaaggca gcgatgtact tatccgcaac ctcctgaggc gtgatgcctt cttccctggc
    37321 acggttgata atcttatcat ccacatctgt aaaattggaa atataggcaa ccttataccc
    37381 acggtactca aaatagcgac gaatcgtatc aaaagctacc gtcgaacggg cgtttcccac
    37441 gtggatatag ttgtacaccg ttggcccaca aacatacatc ttgatcttgc cgtcctcaat
    37501 cgggacaaat tctcgcaaat cacgagacat ggtgtcatag attttaatca taaatcataa
    37561 tcaggaaagc taaaatccaa gaactgttag tttcatcact aaactaagag ctcaagtaaa
    37621 tttcagtccg aatgtctcta cacttcggaa tcccttgctc ctttctcatt cagataaacc
    37681 acctgtgtct gtttgacaaa gccaattttt tcatacaaac gtttggcacc tacattgcta
    37741 tcttccactg caatctgaaa ttccttatca ttttgctcaa ttagttggtt gacaagggat
    37801 tttgctaagt agcttccata gcctttccca cgttcaggtt ctgatattgc taaaccgtag
    37861 aagtaattcg tatcgctcga taaatcaacc gtgcaagtcc caataacctg accagctttt
    37921 aataaaatat atagtcggct ttctggatct ttcagagctt cagcgacata tctatccaca
    37981 acttctctcg attcatgttc ctctgaaaat gcctgaaatt ttaattgact aatttgatcc
    38041 tgatacgaac tatctgctaa caaaatttca agatgggaaa catttgctaa cggataaggt
    38101 cttctatcct tacctaacca agtttctgtc tcttcatcct cgattagtcc ccagttactg
    38161 gcaaagtcag gatgattctc taaaaaaata cgttctgtct gaaaagtgac tgaccgaata
    38221 gggaaagaag ctgtttctct ctcaaaacta gtaaacaatg cacgcgcaat cccctgacgg
    38281 cgatgacctg gatgaaccag tatcgtcact tctacatctt ggtcatctgc atagacagtt
    38341 aataaaccaa caagtttgcc tttttcataa taaaggaaaa aggcgggcat gtttgggtca
    38401 aaattaagca tgttagagag atagggatcg cgataggtac cgtcatagtt ttggcaacag
    38461 ttaattactt ttttcgcctc agatagctcc tcttggctta acttgtttct tgcttgaatc
    38521 atataggtat cctctacaaa ccagacgatc tgtgactggc atctttagcc tgctcgagtt
    38581 tattgacata atactctcgt ttttcttcga ctgcgtgaat aacaggctca tctttcttac
    38641 catgaagacg gacaatcttg gccggaatac cgacaaccgt cacatcacta ggtacatctg
    38701 ctacgacaac tgctgcagca ccgaccttgg cattttcacc aatttccaca ggtccgataa
    38761 cttgggcatg ggctgatatg agggctccct ttcgtacagt cggatggcgt ttgccacagt
    38821 ctttccctgt tcccccaaga gtcactccgt gatagagaag aacgcctttt tcaacaatcg
    38881 ctgtctctcc aatcaccaga ccagaaccat ggtcaataaa gacacctgaa tcaatctggg
    38941 ctcctggatg aatctcaatc tgagtccaaa agcgccaaaa ctgactgtgc atacgagcta
    39001 agagtttgaa gctgtgcttc cagagaaaat gcgagagacg gtgggccgcc aaggccttga
    39061 cacctggata agtcagcaaa acctccaaag tggtgcgggc cgctggatca ttttctttta
    39121 cgatatcaat ggtttcgcgc caccacccca tacatttctc cttttcttat tctgaatctt
    39181 ttggtgtttc tgtaaattct ttcttaggtt tgtgatcctt gtgatgacgt gggcggtgag
    39241 ggcgctcaga cttttcacct ttttcatcat gctcaggttt tggcggacga ggtagaagag
    39301 ccttcataga agcatcgata cggccttttt catcaatctt gataacctta acatcaactt
    39361 catccccgat ttctaccaaa tcctctacac gattggtacg agtccaagcc atctcagaga
    39421 tatgaacaag ggcatctgtc ttatcaaaga ggttaacaaa ggcaccaaat ttctcgatac
    39481 gaacgacttt agcacggtaa acttcatcca ctttggcttc acgaaccaaa ccagcaataa
    39541 tttctttggc acggttaata gcatcttggt cactagagta gatagacaca tttccttctt
    39601 cgtctatatc aatcttaaca cctgtttcag caataatctt gtcgatggtt tctccaccct
    39661 taccgatgac aatcttaatc ttgtccacat caatcttgat cgtatcaatt ttcggagcag
    39721 ttggagccaa ttctggacga acttctggaa tggttgcttc aatgacatca aggatttcaa
    39781 aacgcgcttt cttggcttga gcaagagcct ccgtcaagat ttctgcagta atcccttgaa
    39841 tcttgatatc catttgaagg gctgtaatcc catcacgagt acctgcaacc ttgaagtcca
    39901 tatctccaaa gtgatcttcc aaaccttgga tatctgtcaa tactgtgtag ttatttccat
    39961 ctgagataag tcccatagca ataccagcta ctggcgcctt gattggcaca ccaccagcca
    40021 taagggcaag agttcccgca cagatagaag cttgagatga agaaccgttt gattccaaaa
    40081 cttctgctac tagacggata gcgtatggga attcttccaa gcttggcaag acttgagcaa
    40141 gagcacgctc accaagagca ccgtgaccga tttcacgacg acctggcgca ccgtaacgac
    40201 ctgtttcccc tacagaatat tgagggaagt tatagtggtg cataaagcgt ttcttgtact
    40261 ctggatccaa accatcaatg atttgagttt ctcccatcgg agccaaggtc aagactgaaa
    40321 gagcttgagt ttgcccacga gtaaagagac ctgaaccatg tacacgagga aggaagtcaa
    40381 caaccgcatc caaaggacgg atttcatcga ccttacgacc atcaggacgc accttgtctt
    40441 ctgtaattaa acgtcgcact tctgcgtgtt ccatttgttc caagatttca gccacatcac
    40501 gcataatacg gtcaaattct tcgtggtccg catatttttc ttcgtaaacg gcagtcactt
    40561 ggtctttcac tgcttgagtt gcagcttcac gggccaattt ctcttctact tgaactgcct
    40621 tttggaggtc actgttgtag gctgcaatga tttcagcttg caattcagca tccacgtgaa
    40681 gcaattccac ttctgctttt tctttaccga cagcagcaac gatttcttct tggaaggcaa
    40741 tcaattcttt gacagcttcg tgccctttaa gaagcgcttc caacatgatt tcttctgaca
    40801 attctttggc accagactct accatgttga tagcgtgctt ggttccagct actgtcaatt
    40861 caagaagaga ttgctctgct tgttcttgac ttgggttgat gatgatttgg ccatctacat
    40921 atcccacttg taccccagca attggtccgt caaatggaat atctgaaata gacagtgcca
    40981 aagatgaacc aaacatagca gccattggtg cagatgcatt ttcatcataa gaaagcactg
    41041 tattgatgac ttggacttca ttacggaaac cttccgcaaa cataggacga atcggacggt
    41101 caatcaaacg cgctgtcaag gtcgcatctg ttgaaggacg tccttcacgt ttcataaagc
    41161 caccaggaaa cttcccagcc gcatacattt tttcttcgta gttgacttgg agtgggaaga
    41221 aatccccagt tgccattttc ttagacataa cggcagcagt caagacagtt gactcaccgt
    41281 aacgtacgac aacagatcca tttgcttgct tagcaacctg accagtctct acaattaact
    41341 cacgacccgc aaaagtcgtt tgaaacactt gttttgccat tttaatcccc tttggattga
    41401 tgaaattata cgccttgcct acaaagatca agataccaag gacgtcaaaa gcaaagtaaa
    41461 aataggaaac tgacgaagtc ttcgatgaag acaagacagt ttatcttttt tacacagctt
    41521 ttcggccgtg ttcaattaca caagatattt tggacggttc ggcttgccga acatttctgt
    41581 agaaaaatag gaaggtgact tcgcactcga cgagtgctag gaagcttatc ttttttccta
    41641 agaaatgaga ccaaaattca agtcatcaag ataccaagcc gtcaagcaac tcaaaggaag
    41701 ataggaaatc gaacgacgga gcgactgctc ctagggagat ttatcttttt ccacagagtt
    41761 gtaggcaagt tcagttttca agatacatca ttagaaaggt ttaatactaa agtatctaaa
    41821 gctttcacgc taatcgctat cgggcgatta gctaaatgct ttactaactc tctcgtcaaa
    41881 taacatcgat ttgactcact cgtgtcgtta aatcttacag tttaaatgca ttgtattatt
    41941 taataccttc atctttgtat caagtacgta cagaatttat tttatcatat ttttcttaaa
    42001 aagtgaggtc tttaccatta aaaaggaacc attcccctca cctgagaaga atggtttgct
    42061 tttattatcc tagagactgg tgattaaaca aggcatgggt tgcttgatgg atgtattttg
    42121 ctgtatcagc attattcatc gtatagagat gcacaccggc aacatcctga gttaccaagt
    42181 ctacgatttg gtccactgca taggcaagtc ctgctgctct gagcgactca gggtcatgct
    42241 catacttgtc taagatggct ttaaatttgc gtggaagatg gatattctca caagtcttca
    42301 agagtcggag agcctgattt cgattcagaa ttggcataat tcctgcatga atgggaacat
    42361 caatcccagc caagatgcac ttgtcctgaa aatcatagaa gtgctcattg tcaaagaaga
    42421 gctgagttac gaggctcgaa cagcctgcat ccactttctt cttaagattt tgaatatctg
    42481 aaatctgatt tggcgaatct ggatgccctt ctggatagca agctccaata atatcaaagt
    42541 gaggggcttg ttccttgata agctcaatca agtcggttgc atagcggaaa tccttttgtg
    42601 gttccacgtc tggaataata tccccacgaa gagccaagat tttctgcacc ccaactttgt
    42661 ccaagtcagc aatagtttca gcaaccttgt ccttagttag ataaatagct ggcaagtggg
    42721 caatggtcgg aatcgccaag tcattttgga taaagtcagc caaacgaacc gtcgtttcct
    42781 tgatattaaa tttattattg ctggcagtta cactgataaa atggggagcc aactcctgca
    42841 tatcctgcaa ggctaaaata atgttatcat tacccacggc tgggtttgga gggaacactt
    42901 caaatgagag tgacggtgtt tggcatgaca tatgtaataa ccttttctag ttgatttctt
    42961 tttgaacaac cactgtatgg agagaaatcc aatcttacaa tttctcacgc gcagctttag
    43021 ctgcttcaac aaggcggatc aagctttctt ttgtttctgg gataccacgt gttttcaaac
    43081 cacagtcagg gttgatccaa actttcttgc ttggcacttt agcaaggatg gcttcgattg
    43141 tgttgtcgat ttcgccttca tttggtacac gaggtgagtg gatatcgtaa accccaggtc
    43201 ccacttctgt ttggaagttt ttcgctttga gttcgtccaa gatttcaagg tttgaacggc
    43261 tggcttcaaa ggaaataacg tctgcatcca tgttatcgat agctgggatg atatctgtaa
    43321 attctgagta acacatgtga gtgtggattt gtgtgtctga cgctactgtt gagtgtacca
    43381 agcggaaggc aggaattgcc cagtcaaggt aatcttcgta ccagtcacta cgacggagtg
    43441 gcaatttttc acgaagagca gcctcatcaa tttggatgat tttcacacca gcagcttcaa
    43501 ggtcaagcac ttcatccttg atagcaaggg cgatttgaag agtagaatcc ttgatagaga
    43561 tgtcttcacg tgggaatgac cagttgagga tggtaacagg tccagtcaac atacctttaa
    43621 caggtttgtt tgtacgactt tgtgcatagc tagaccattt aacagtgata gggttaagac
    43681 gagtgacatc accccagatg attggtggtt ttaccccacg cataccgtat gattgtaccc
    43741 atccattttt agagaagagg tatcctgaca agttttgacc gaagtactca accatgtcat
    43801 tacgctcaaa ttcaccgtga acaaggacat caaagtcaat atcttcttgc cacttgatcc
    43861 attcgtcaat cgtttcagca aggaaagcgt cgtactcttt ttgagacaat tcacctttac
    43921 ggtaagccaa acgtttggca cgaacttctt ttgtttgagg gaatgaacca atcgttgttg
    43981 ttggaagagc tggaagttta aaagcttctt cttggatagc ttcacgttct gcaaaggctg
    44041 gcaaacgagt gtagtctgcg tctgtcaagc cagcgatacg cgcacgaagt tcagcatttt
    44101 caccaacacg ctcagtcgca aagagttctt tgttggctgc aagagcttct gaaccttgac
    44161 cattgcggat agcatccaag tcacggattt catccaattt ttcaactgca aaggcaaagt
    44221 ggttcaagag tgctggttca aattcttcat tagcagttgt aaatggcaca tgaagaagtg
    44281 agcaagagct tgtcaaaacg atgttttcag ctgggatttg ctcaagaaca gccaagctct
    44341 tttcgtagtt gttacgccag atgtttttac cattgacaat acctgcatag agagtcttgt
    44401 cagctgggaa gccaccttta acgagttcaa gagttttctt accttcaaca aagtcaagac
    44461 cgatagcatc tactggtaag tttacaaggt cagcgtatac gtcacgaaca tcaccgaaat
    44521 aagtttgaag caagacttca agaccttttt tgtcagccaa gagtttgttg taaaggttca
    44581 agaagagagc tttttcttca gctgtcaagt cttttacaag agccgcttca tccaattgga
    44641 tgcgagtcgc accaagttca gccaatttag caaaaacttc ttggtaagca actactaagc
    44701 tatctacgaa gtcgtctgct ttcacgcctt cttcaaagtc tgacaattga aggaaagtga
    44761 agggacctac aagaacagga cgagtgttca atccaagttc ttttgcttct tggaactcat
    44821 cgaaaatctt gtgaccagcc aattttactt gagtgtcttt ttcaaattta ggaacgatgt
    44881 agtggtagtt agtgttgaac catttcttca ttggaagggc gcgaacgtcc cctttttctc
    44941 cctggtaacc acgtcccaaa gcgaagtagc gctcaaggtc agacaagtcc aagttttgaa
    45001 cggatgcagg caccacgttg aaaaggaaag ccgcatctag gaagttatca tagtgagaaa
    45061 agtcatttga tggaatttca gtgatgcctt tttctttgac aatgttccag tgtttagcac
    45121 gcaagtcttt tgctgctgct aaaagttctt cttctgagat ttcttttcta aagtattttt
    45181 cagttgtaaa ttttaattca cggaattcgc ccaaacgagg gaaaccgatg attgtagttg
    45241 acatgatgtg tcctccaaaa tttgttgttg aaactatctt aacagaaaag aaagcgtctg
    45301 tataattgta aaaaattagg gtttgatata gtttgaaact atatatctgt ttcggacaaa
    45361 agaaaaagac ttgaagcaaa catctcaaat cctttgtaat tcttacttta cagctatatt
    45421 ccaattagaa tactaaaaca tgttattagt aattcttata agtgactatg acctgttatt
    45481 agaaaagact ataactgatt ctagtcaact tttcccctgt tcaagtggaa cgactgctag
    45541 tgtctttcct agactggtta gaacttttaa gaccgtatcc aactgaagac tgctctctcc
    45601 tgtctccatc ctagctatga caggctggct tattccactg acttcttcca gctttttctg
    45661 actgattcct tgttcatacc tagcctcaat caactcgctc atgatagcca ctcgcatatc
    45721 actttcaagg atttcctcct tgctaaagag ctcagatgga catccttcca attactccca
    45781 atagcactat tcttcatcac ttaaccctct tttttttacg tctatgtatt tttaaaaaaa
    45841 tgagcgaatt atgattcgat agattgacca gcgggtttaa agttggtgct agcctatttc
    45901 ttaagcgatt ttccttttct aggataaagc agatcctgct tgcttaaccc caattttcca
    45961 cgatgaattc aatagtaaat ggttgaaatt cccacgttaa cccctttagc catcaccatc
    46021 atttcaggcg aaaatttttg gttatgtata gtggagaatc ttttccttta gtttcttaag
    46081 actgttgagc gtagtcggca gaataaatct ctttgaagcg cccttttcca agacattgtc
    46141 ggactgtccc acgcttgatt tcagtgtgga tagtttgagg agcttttcca agtagagagg
    46201 caatttctct atttgatttt ccttcttttt tccatcgttc gattaagcga cggctatcga
    46261 ttgtcaaatg tttgcctttt gtagtataat tgtcttgcat ttctgtgcct tttaatcatt
    46321 tcaatcttaa attgaacttt tttacttggg ttgtacttaa tctatgagga agacaagaaa
    46381 aagaatatca atcaagtaaa gtcacattag ctccgagcaa ccattgcaaa ttgaggtact
    46441 cacacaatga ttaaaacatt tctctctgcc ctttcggtca ttctctttgt tatccctatc
    46501 atagcttatt ctttttttcc atcttctaat cttaatattt ggctatctac cagacctatc
    46561 ttggcacaga tttatgcctt ccccttagct actgcaacta tggcttctat tttaagtttc
    46621 gtattttttt ccctatcttt ttacaagaaa aataaacaaa tacggtttta ctctggcatt
    46681 ttgctcttac tatcgctcat attactatta ttcggaacag ataaaaccct ttcttctgca
    46741 tcaaataaga ctaaaacctt aaaattagta acttggaacg tcgctaatca aatagaagca
    46801 caacatattg agcgaatttt tagccatttt gatgccgata tggctatatt ccctgaacta
    46861 gctaccaata tcagaggtga gcaagaaaac cagagaatca aactattgtt tcatcaagtt
    46921 ggactttcta tggccaacta tgatattttc acttctccac ctaccaatag tggaatagct
    46981 cctgtgactg tgattgtcaa gaaaagttat ggtttctata cagaagctaa aacttttcat
    47041 acaacacggt tcgggacaat tgtattacat tcgagaaaac aaaatatacc agatatcatt
    47101 gccttgcata ctgctcctcc tctgccaggt ttaatggaaa tctggaagca agacttaaac
    47161 atcattcata atcaattggc ttcaaaatat ccaaaggcta ttattgcagg tgattttaat
    47221 gcaactatgc gtcatggagc acttgcaaaa ataagctctc atagggacgc attgaatgca
    47281 cttccacctt ttgaaagagg aacttggaat agccaaagtc caaaactttt taatgcaacg
    47341 atagatcata tcttattgcc taaaaaccac tactatgtta gagatttaga cattgtaagt
    47401 tttcaaaact ctgatcatag atgtattttt acagaaatca cattttaatt attttatata
    47461 aaatcacccc tctagtgttc ataaactaga gggggaattt gtatcatact atcgtttaac
    47521 gcacttctgc attcactttt tcttcgagcg atacttggat tttttccata tagcgtgcga
    47581 cttcttcgtc cgttaagcta tcttctggat tttggaaggt caagctataa gccattgact
    47641 tcataccaag tcccaatttc tcacctgaga agacgtcaaa gagtttgata tctgtcaaac
    47701 gtttcacgcc ggcagcttgg atagcatcta caacttcttg atgagtcact tctgccttga
    47761 ggagaagggc aacgtcacgg ctgactgccg ggaatttggt gatttctaca aatggagtcg
    47821 ctggctgaag cgcagcttcg atagctgaaa ggttaagctc agctacatac gtttctggaa
    47881 tatcataagc cttagcagtg actggatgca cttggccaag gaaaccaaga acttggtcac
    47941 cgagtgaaat gactgctgta cgacctggat gaaggctagc gatttcagat gttgctgtat
    48001 aggttacttg gagtcccaag cgagtaaata gggcttcaag gattccctta gcatagaaga
    48061 aatcaactgg aactgctgct gtttggaaat ctttttcagc aaccaagcct gtcaaggcaa
    48121 aggcaaaact gttaatttca tttggaagtt cttctcttgg attacctgtt tgttcaaaga
    48181 cttttccaat ctcgtaaagg gccaagtttt tattcttacg agccacgttg taggcaacgg
    48241 tatcaaggat acctgaaatc atattttgac ggaggactga acgatccaca gtcattggcc
    48301 acatgagttc cgtaaggtta cttggttgag ccgtaaactc aactgctttt tcaggagttg
    48361 ttagagcata ggtgatgatt tctgtcaaac ctgctccttc agcaatggta cgaacttgac
    48421 ggcggagttt ttgtgtcaca gtcaattcac cagctgtacc atcgtctttt ggtagactag
    48481 ttggcaagcg gtcatatcca tagatacgag cgatttcttc aaagaggtca gcttcgattg
    48541 tgatatccca acgacgacgt ggtacgctga ctgtaaagct gtctgcattt ccagaaagac
    48601 caaaaccaag acgacggaag acgtcttcga catcagcata agacagctca gttccgagga
    48661 cacggttaac atcagcaagg gttgaagaaa cttccacatc agaggtatca agctcacccg
    48721 ctgaaacgat acccttacgc accgtcgcac ctgcaagttc tgcaatcatg ctagctgccg
    48781 catcaagggc ttcattgact gttgccacat tgatgccttt ttcaaagcga gaagacgatt
    48841 ctgaacgaag gttcaggcga ccacttgtct tacggataga tttaccattg aaaacagcag
    48901 cttcaaggac aacacgacta gatttttcag agatttctgt tgcttgacca cccatgacac
    48961 ctgcaagggc tactggcttg tctgcaacag tgatgactag gtcattcacg tccaagtcac
    49021 gttcttcacc gtccaaggtc accaattttt caccagcacg cgcttcacgc acacggatgt
    49081 cagtcccttc aaatgtgtcc aagtcaaaag catgcatagg ttgaccaaag tagagcagga
    49141 tgtagtttgt cacgtctaca acgttattga tgggacggat gccttcgttc atgagaaggt
    49201 tttgcaacca ttgtggactt ggtgcgataa tcacattgtc caagatacga gctgcatagt
    49261 aaggcgcctt gtctgtccca atgctgacag aaagggcatc tgccgcagct tcattagttt
    49321 ctgttagagt aaattcttta aagttgactg ccttgtcata gatggctgcc acttcgtgag
    49381 ccactccaca catagaaagg gcatctgcac ggtttggtgt gatggaaagt tcgatgattt
    49441 catcatccaa gtctaggtaa gaaaagactt cctcacctgg cacggtattt tctggcaaga
    49501 tttggatgcc atctgcgaat tccttaggca caactgagtc agaaattccc aattcaccaa
    49561 gtgaacagat cattccaagt gactccaaac cacggatttt tccttttttg attttgtagt
    49621 tatcagcgat acgagctcct ggaagagcca ccatgacctt gatcccagca cgcacatttg
    49681 gggcaccaca aacgatctga cgggcttctt cttcgccaac gttaacctga caaacatgga
    49741 ggtgagtctc tggcacatct tcgcaagaca agacctcacc gacaacaatt tttgagagat
    49801 cagcagctgg tgattcgaca ctctctacct cgatccctgt ggttgacatt ttttcagcca
    49861 actcctgtga tggcacatca atgtccacca attcttttaa ccatttataa gatacaagca
    49921 taatttagtt ctccagaatg accattgcca cactggttct tttcctttcc tatcatttca
    49981 atagaagaat cctcttctta ccttaatttc tttctcagta accaatccgt atctactttt
    50041 tgaccaacca taaaatgatg ttggctaaat ttttcaaaac catatcgatt ataaaacgct
    50101 tgagcttttg tattatgctc ccaaacacct agccaagccc aagaaaaact attttttgta
    50161 gcaagttcaa gtgcgaattc aaacagttgc ttacctattc caaatccttg gaatttttgt
    50221 agcacataga ggcgttgaat ttcaaaagcg tcctctaatt ctctctcagt ttgagcactt
    50281 ccccagttga ctttgagaaa accagctatc tcctcctcat gcataatgaa ataggtttca
    50341 gagtcaggat ttcccaactc agttgacaaa gttttcagac tataagcctc ttcaaagtat
    50401 tcctgtaact gctcttccgt attatcatac gcaaaggttt cacgaaaggc ttgtttggca
    50461 attttagcca acacctcaac atctgccatt tctacttttc taatcattat ttaaactgtt
    50521 ctgagaagcg gacatctcct tggtagaatc cacggatatc gttgattcca taacggagca
    50581 tagctacacg ctcttgtcca agaccaaagg caaaaccaga gtatacagtc gcatcgatac
    50641 cactcatttc aaggacacgt gggtgaacca taccggctcc cataatttcg atccaacctg
    50701 ttttcttaca tacgttacag ccttctccac cacacttgaa gcaagaaaca tccacctcaa
    50761 cagatggctc tgtgaatggg aagtaagatg gacgcaaacg aatttgacgc tcttcaccaa
    50821 acattttttg gacaatcaac tgaagcgttc cttgaagatc agccatagag atatttttcc
    50881 caactaccaa gccttcgatt tggtggaatt ggtgactgtg ggtcgcatcg tccgtatcgc
    50941 gacggaagac acgccctggc gagatcatct tcaaaggacc tttagaaaaa tcatgggcat
    51001 ccatagcacg cgcctgaact ggagacgtgt gggtacggag caagatttct tcagtgatat
    51061 agaaagtatc ctgcatatca cgagctgggt ggtcttttgg aaggttcata cgttcaaagt
    51121 tatagtagtc ttgctctact tcaaaaccat ccacgacttg ataacccata ccgatgaaga
    51181 tatcttcgat ttcttcactg gtttgtgtca aaacgtgacg gtgaccagtc gcaactggac
    51241 gacctggaag cgtcacatcg atactctcgc tagccagttg agccgcgact ttcttttctt
    51301 ccaagagctt agctgtttct tcaaaagcag cagtcaagac atcacgagct tcattgacgt
    51361 gtttcccgat gattggacgc atctcagcag aaacatcttt catccctttg aggatttcag
    51421 tgagcgaacc ctttttacca aggacagaga cacgcaaatc ttgcatctct ttttcatttc
    51481 cagcagtaat ctgcttcaag ctagccagcg tttcttcgcg aagcgctttt aattgttctt
    51541 caatagttga catatttcct ccatcagtct ctcgtagata aaaagaaaac cacatgccaa
    51601 aaactccact cggagcgttg acacgcggta ccatccgttt tcatctgaca agtcagacct
    51661 tcatttctaa atccatgcgc aagtgaattc acccagcttt catatagaga gcttgcagtc
    51721 acggctctcc tccctgatat acttcccctg ggctactagt ctttcagatt cctattcaat
    51781 tactacttag tttatcagat ttttaccatt cttgcaagac ctatcttact tctgcttgtt
    51841 agcttattct tatctaactt tatagcggat tgaaataaga tgaa
//
LOCUS       DAVHIZ010000007        50462 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.007, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000007 DAVHIZ010000000
VERSION     DAVHIZ010000007.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 50462)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 50462)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..50462
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.007"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            120..1127
                     /locus_tag="VVO18_000428"
     CDS             120..1127
                     /locus_tag="VVO18_000428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEU5585641.1"
                     /translation="MTEKLINSKPNGVFALILIELTIVLGIFIFIMGVGSENIFGIII
                     GPLLIVIAGLAHAGLKVVKPQEALVLTLFGNYTGTIKEPGFYFVNPFSVAVNPANHTR
                     LGQSGDVSTKSPFLGAKSSNDNDVNLEIGKKQISLKVMTLSNSRQKINDCLGNPVEIG
                     IAVTWRVVDTAKAVFNVDNYKEYLSLQCDSALRNIVRIYPYDVSPNVDTTGDGQADEG
                     SLRGSSEIVANRIREEIQSRVEDAGLEILEARITYLAYAPEIAAVMLQRQQASAIIDA
                     RKMIVDGAVGMVEMALERLNEGELVELDEERKAAMVSNLLVVLCGNHDAQPIVNTGSL
                     Y"
     gene            1130..1330
                     /locus_tag="VVO18_000429"
     CDS             1130..1330
                     /locus_tag="VVO18_000429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU5585642.1"
                     /translation="MAEAKKKQIPLRLSTKLYAALASWAEDDFRSVNGQIEYLLTECV
                     KQRKKDGKYVSETIDEPFEIDI"
     gene            1482..1664
                     /gene="rpmF"
                     /locus_tag="VVO18_000430"
     CDS             1482..1664
                     /gene="rpmF"
                     /locus_tag="VVO18_000430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L32"
                     /protein_id="HEU5585643.1"
                     /translation="MAVPARRTSKAKKNKRRTHYKVTAPSVNFDETTGDYSRSHRVSL
                     KGYYKGRKIAKAVSAE"
     gene            1680..1829
                     /gene="rpmG"
                     /locus_tag="VVO18_000431"
     CDS             1680..1829
                     /gene="rpmG"
                     /locus_tag="VVO18_000431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001265622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU5585644.1"
                     /translation="MRVNITLEHKESGERLYLTSKNKRNTPDRLQLKKYSPKLRKHVV
                     FTEVK"
     gene            complement(2251..4131)
                     /locus_tag="VVO18_000432"
     CDS             complement(2251..4131)
                     /locus_tag="VVO18_000432"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEU5585645.1"
                     /translation="MVRFTGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGE
                     EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS
                     AKQMIEVLALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF
                     VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN
                     IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA
                     DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG
                     GAWKWIGFTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIW
                     AELSYRNDLDGLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDVL
                     CPILDQHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSKVDVGRRI
                     RQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLL
                     QRIKRAESRIEVYLAGQLDRIDELEVEILPFTDFYADKDFAATTANQWHTIATASTIY
                     TT"
     gene            complement(4125..4994)
                     /locus_tag="VVO18_000433"
     CDS             complement(4125..4994)
                     /locus_tag="VVO18_000433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU5585646.1"
                     /translation="MTIATIDIGGTGIKFASLTPDGKILDKTSISTPENLEDLLAWLD
                     QRLSEQDYSGIAMSVPGAVNQETGVIDGFSAVPYIHGFSWYEALSSYQLPVHLENDAN
                     CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAEKL
                     NNWSQLASTGNMVRYVIEKSGHTDWDGRKIYQEAAAGNALCQEAIERMNRNLTQGLLN
                     IQYLIDPDVISLGGSISQNPDFIQGVKKAVEDFVDAYEEYTVAPVIQACTYHADANLY
                     GALVNWLQEEKQW"
     gene            complement(5078..7723)
                     /locus_tag="VVO18_000434"
     CDS             complement(5078..7723)
                     /locus_tag="VVO18_000434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000432759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-mannosidase"
                     /protein_id="HEU5585647.1"
                     /translation="MENVVVHIISHSHWDREWYLPFESHRMQLVELFDNLFDLFENDP
                     EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR
                     NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVAAFGRGVKPIGFDNQV
                     LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA
                     YASTNQWLMMNGCDHQPVQKNLSEAIRVANELFPDVIFVHSSFDEYVQAVEGALPEHL
                     STVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLLEQVVEPLTIITGGHNHKDQ
                     LTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQVGNFVKSNLLNEWKGKIATD
                     KAQSDYLFTVINTGLHDKVDTVSTVIDVATCDFKELHPTEGYKKMAALILPSYRVEDL
                     DGHPVEATIEDLGANFEYDLPKDKFRQARIARQVRVTIPVHLAPLSWTTFQLLEGKQE
                     HREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYFQPKG
                     TEPIFAELKGHEVLENTACYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREAGRSE
                     ELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIYEVVT
                     RPNKPAASWENPENPQHQQAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASG
                     ELGDWGYFPTPEAQCLREFEVEFAIECHQAQERFSAYRRAKALQTPFTSLQLSRQEGS
                     VVATGSLLSHSVLSIPQVCPTAFKVAENEEGYVLRYYNMSQENVRISEHQQTILDLLE
                     RPYPVHSGLLAPQEIRTEFIKKEEI"
     gene            complement(7814..9094)
                     /locus_tag="VVO18_000435"
     CDS             complement(7814..9094)
                     /locus_tag="VVO18_000435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844830.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 125 protein"
                     /protein_id="HEU5585648.1"
                     /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL
                     EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDSLLRQTIAGLVKRQMTLVLKDPYA
                     NSFNIEENWKGHHETDHTDLNGWIWERKYEVDSLCYPFQLAYLLWKETGETGQFDETF
                     VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD
                     DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADTKRLQDEIQEGIENYAYT
                     TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATRRTILSSEN
                     PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKKFLLDQLVACDGGTGVMH
                     ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR"
     gene            9265..11349
                     /locus_tag="VVO18_000436"
     CDS             9265..11349
                     /locus_tag="VVO18_000436"
                     /EC_number="3.2.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000803403.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GH92 family glycosyl hydrolase"
                     /protein_id="HEU5585649.1"
                     /translation="MKPLLETIDTRFGTTNKHAFSRGNTLPYTGVPFGMNYFVPQTSD
                     QDGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDIDK
                     ACFQPHYLKLFSLRYQIETQLTPTCYGASIRLNQKQGKALSLYLHAADELTVEQVDKR
                     TLALRQEGKTETNKNSLTMFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS
                     PSQALLNLPQEDFDSCKSSAQADWENLLHRFDIIEIGEADRTFFDHCLYRLFLFPQTF
                     YEINESGQAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN
                     SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSACKDMAPDLEGELFQAMLETASKADP
                     LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIASCAKKLENIEIAETYKAA
                     SQNYRQLFDAETGYMRARDNQGNFHPDFSPYSWGRDYAECSAIQATLGVLHDIPGLIQ
                     LMGGKETFSNYLLKACQDAPLFETTGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL
                     FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS
                     YDLGIPLFDHLRVYLAKEDKWLDIHTKQNHNHFNFVKECRLDKTLVSTIQHQDLLKAE
                     QLTFTLSWLPSH"
     gene            complement(11389..13068)
                     /locus_tag="VVO18_000437"
     CDS             complement(11389..13068)
                     /locus_tag="VVO18_000437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000721501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-L-fucosidase"
                     /protein_id="HEU5585650.1"
                     /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE
                     DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK
                     GDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADYNAYYLAQLKEILSNPAYG
                     NGGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGACLIFSTEGTSIRWIGNERGY
                     AGDPLWQKVNPDKLGTEAELNYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLE
                     ELVEIYFYSVGRGTPLLLNIPPNQAGLFDAKDIERLYEFATYRNELYKEDLALGAEVS
                     GPALSADFACRHLTDDLETSSWANDADLPIQLELDLGSPKTFDVIELREDLKLGQRIA
                     AFHVQVEVDGVWQEFGSGHTVGYKRLLRGAVVEAQKIRVVITESQALPLLTKISLYKT
                     PRLSQTVAVQGLAFAEKSLAVAKGETLHFRIERSESSSSLEAKISIQPGTGVHGVAYQ
                     DEIQVLQFQAGESKKDLHLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS"
     gene            13824..15053
                     /gene="arcA"
                     /locus_tag="VVO18_000438"
     CDS             13824..15053
                     /gene="arcA"
                     /locus_tag="VVO18_000438"
                     /EC_number="3.5.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000094613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine deiminase"
                     /protein_id="HEU5585651.1"
                     /translation="MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIP
                     FLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQT
                     KVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDEAKDLTDLVESDYPFAIDPMPNL
                     YFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIE
                     GGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDT
                     VFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIR
                     CGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVR
                     GRGGPRCMSMPFEREEV"
     gene            15111..16127
                     /gene="argF"
                     /locus_tag="VVO18_000439"
     CDS             15111..16127
                     /gene="argF"
                     /locus_tag="VVO18_000439"
                     /EC_number="2.1.3.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003073325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine carbamoyltransferase"
                     /protein_id="HEU5585652.1"
                     /translation="MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHY
                     LAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRM
                     FDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLV
                     YCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITED
                     ADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPA
                     FHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLY
                     IPKV"
     gene            16292..17239
                     /gene="arcC"
                     /locus_tag="VVO18_000440"
     CDS             16292..17239
                     /gene="arcC"
                     /locus_tag="VVO18_000440"
                     /EC_number="2.7.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003025409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamate kinase"
                     /protein_id="HEU5585653.1"
                     /translation="MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGD
                     DLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDE
                     GIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWR
                     KVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFAS
                     QRLAELVDADLFIVLTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPK
                     VEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG"
     gene            17450..18961
                     /locus_tag="VVO18_000441"
     CDS             17450..18961
                     /locus_tag="VVO18_000441"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004191872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfcC family protein"
                     /protein_id="HEU5585654.1"
                     /translation="MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYET
                     QPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAIDVAFFILMVGGFLGIVNKTGA
                     LDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS
                     LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFV
                     YRYADKIQKDPTKSLVYSTRKEDLKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMV
                     LSFIPWTDLGVTIFDDFNAWLTGLPVIGNIVGSSTSALGTWYFPEGAMLFAFMGILIG
                     VIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGL
                     SSQVFIVVTYIFYLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGV
                     LNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVAIIVVTIALLLLGTFLPFL"
     gene            18983..20314
                     /locus_tag="VVO18_000442"
     CDS             18983..20314
                     /locus_tag="VVO18_000442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000686986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dipeptidase"
                     /protein_id="HEU5585655.1"
                     /translation="MKIDITNQVKDEFLISLKTLISYPSVLNEGENGTPFGQAIQDVL
                     EKTLEICRDIGFTTYLDPKGYYGYAEIGQGAELLAILCHLDVVPSGDEADWQTPPFEA
                     TIKDGWVFGRGVQDDKGPSLAALYAVKSLLDQGIQLKKRVRFIFGTDEETLWRCMARY
                     NTIEEQASMGFAPDSSFPLTYAEKGLLQVKLHGPGSDQLELEVGGAFNVVPDKANYQG
                     PLYEQVCNDLKEAGYDYQSTEQTVTVLGVPKHAKDASQGINAVIRLATILAPLQEHPA
                     LSFLATQAGQDGTGRQIFGDIADEPSGHLSFNVAGLMINHKRSEIRIDIRTPVLADKE
                     ELVELLTRCAQNYQLRYEEFDYLAPLYVAKDSKLVSTLMQIYQEKTGDNSPAISSGGA
                     TFARTMPNCVAFGALFPGAKQTEHQANECAVLEDLYRAMDIYAEAVYRLAT"
     gene            complement(20795..21010)
                     /locus_tag="VVO18_000443"
     CDS             complement(20795..21010)
                     /locus_tag="VVO18_000443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585656.1"
                     /translation="MGVLGYYEGFVPYVSNQYKNQAEEEGKPLSDKYIFEKILGKTYA
                     AFKKDQINERVEKLGKLKPITINYNGK"
     gene            complement(20998..21249)
                     /locus_tag="VVO18_000444"
     CDS             complement(20998..21249)
                     /locus_tag="VVO18_000444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657761.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEU5585657.1"
                     /translation="MKEFQFERKQRFSLRKYVIGACSVLLGTSLFFAGMGAQPVQDTE
                     TSSALISSHYLDEQDLSEKLKSELQWFELENKLLNLWEY"
     gene            21453..21530
                     /locus_tag="VVO18_000445"
                     /pseudo
     CDS             21453..21530
                     /locus_tag="VVO18_000445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002674100.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(21647..22531)
                     /locus_tag="VVO18_000446"
     CDS             complement(21647..22531)
                     /locus_tag="VVO18_000446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SPFH domain-containing protein"
                     /protein_id="HEU5585658.1"
                     /translation="MIFLIVCVLLLVIVTLSTVYVVRQQSVAIIERFGKYQKVANSGI
                     HIRLPFGIDSIAARIQLRLLQSDIVVETKTKDNVFVMMNVATQYRVNEQSVTDAYYKL
                     IRPESQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMTTYGYIIVKTLI
                     TKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQ
                     RKAIVDGLAESITELKEANVGMTEEQIMSILLTNQYLDTLNTFASKGNQTIFLPNTPN
                     GVDDIRTQILSALRAEKK"
     gene            complement(22676..23827)
                     /locus_tag="VVO18_000447"
     CDS             complement(22676..23827)
                     /locus_tag="VVO18_000447"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862055.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="HEU5585659.1"
                     /translation="MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSD
                     ILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAA
                     SCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
                     MVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAI
                     ELIKEYLPRAVENGYDIEAREGMVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHG
                     VCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYAIAEIEKLSETVGI
                     PKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF"
     gene            complement(23973..25739)
                     /locus_tag="VVO18_000448"
     CDS             complement(23973..25739)
                     /locus_tag="VVO18_000448"
                     /EC_number="5.3.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fucose isomerase"
                     /protein_id="HEU5585660.1"
                     /translation="MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLK
                     YPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIP
                     HAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEASDTAIPEDVKEKLLRY
                     ARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRG
                     IYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNP
                     RLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFAT
                     ENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGCAAAGFLHLINSG
                     SCTLDGTGQATRDGKPVMKPFWELDESEVQAMLENTDFPPANREYFRGGGFSTRFLTK
                     GDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGK
                     GAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSL
                     FGTEDLESADYRACQLLGPLHK"
     gene            complement(25796..28912)
                     /locus_tag="VVO18_000449"
     CDS             complement(25796..28912)
                     /locus_tag="VVO18_000449"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HEU5585661.1"
                     /translation="MNKEKIKRKLITILFVCIGMLCFGLLAGVKADNRVQMRTTINNE
                     SPLLLSPLYGNDNGNGLWWGNTLKGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDT
                     KELREWYVKMLEEAQSLNIPVFLVIMSAGERNTVPPEWLDEQFQKYSVLKGVLNIENY
                     WIYNNQLAPHSAKYLEVCAKYGAHFIWHDHEKWFWETIMNDPTFFEASQKYHKNLVLA
                     TKNTPIRDDAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFETGRARDMRSYA
                     SEPESMIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPTPAFTKGIIPFFRHAIQNPAP
                     SKEEVVNRTKAVFWNGEGRISSLNGFYQGLYSNDETMPLYNNGRYHILPVIHEKIDKE
                     KISSIFPNAKILTKNSEELSSKVNYLNSLYPKLYEGDGYAQRVGNSWYIYNSNANINK
                     NQQVMLPMYTNNTKSLSLDLTPHTYAVVKENPNNLHILLNNYRTDKTAMWALSGNFDA
                     SKSWKKEELELANWISKNYSINPVDNDFRTTTLTLKGHTGHKPQINISGDKNHYTYTE
                     NWDENTHVYTITVNHNGMVEMSINTEGTGPVPFPTPDKFNDGNLNIAYAKPTTQSSVD
                     YNGDPNRAVDGNRNGNFNSGSVTHTRADNPSWWEVDLKKMDKVGLVKIYNRTDAETQR
                     LSNFDVILYDNNRNEVAKKHVNNLSGESVSLDFKEKGARYIKVKLLTSGVPLSLAEVE
                     VFRESDGKQSEEDIDKITEDKVVSTNKVATQSSTNYEGVAALAVDGNKDGDYGHHSVT
                     HTKADSNAWWQVDLGEEFTVSKVDIYNRTDAEPQRLSNFDVIFLSSSGEEVFRRHFDK
                     VVDGLLSLKVPSVGAKLVKIELKSAAIPLSLAEVEVYGSKRTPKKLSNIALTKETRQS
                     STDYNGFSRLAVDGNKNGDYGHHSVTHTKGDSPSWWEIDLAQTEELEKLIIYNRTDAE
                     IQRLSNFDIIIYDSNNHEVFKQHIDSLESNNLSIDLKGLKGKKVRISLRNAGIPLSLA
                     EVEVYTYK"
     gene            complement(28922..31216)
                     /locus_tag="VVO18_000450"
     CDS             complement(28922..31216)
                     /locus_tag="VVO18_000450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HEU5585662.1"
                     /translation="MKLWYKKAASNWNEALPIGNGHLGGMIYGSATKECIQLNDETIW
                     YRGKSDRNNPDSLLHLKKIREYLLDGEIQKAEELIKLTMFATPRDQSHYELLGELYIE
                     HIDIQSCALSLYERELDLDTAISNVVFDPNSCNLQIKREYFTSFNKNILCCRIVSSVQ
                     NTLNLNINLGRNKRFNDEVSKLDSSTILMSASAGGRKGVQFKVVCHSKVTDGEVSVLG
                     ETIVIRNATEVFLYLKSMTNYWGNIDISSLQGEFSSIDYFTEKDEHVKKYQEQFNRVD
                     FKLDYSKDCLSIPTNLLLENTKKYSNYLTNLLFHYGRYLLISSSQPNGLPANLQGIWC
                     DELNPIWGSKYTININTQMNYWMVGPCDLPEVEYPLFDMLERMREPGRLTAKKMYGAR
                     GFTAHHNTDGFGDTAPQSHAMGAAIWVLTIPWLCTHIWEHYLYFQDERILTEHFEMIK
                     EAFLFFEDYLFEVDGYLMTGPSVSPENKYRLKNGIEGNACLSSTIDNQILRYFCDSCI
                     GIAKQLGDNSDFISRVKELKKKLPKTKIGSNGQIQEWLEDYEEVEPGHRHISPLFGLY
                     PYNEIDIHKTPELAEAAKITINRRLSNANFLSSQEREQAINNWLVSGLHASTQTGWSA
                     AWLIHFFARLYQGEPAYNQINGLLNNATLGNLFLDHPPFQIDGNLGLVSGICELLVQS
                     HHNWLSLIPALPSAWSEGEVKGFRVRGGYKVSFAWKNGDITFLKLEGGNKDQKVRVRI
                     YGKNTDVQNIELVFNSEKIIELNF"
     gene            complement(31275..32075)
                     /locus_tag="VVO18_000451"
     CDS             complement(31275..32075)
                     /locus_tag="VVO18_000451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU5585663.1"
                     /translation="MMNNKVTKVELKKVFKRSFMYGSSWNYERMQNLGFLYTILPVLK
                     KLYPDKDSASPAMKRHLEFFNTHQTAAPFILGVTSAMEEQEGNEGAASITGIKVGLMG
                     PLAGLGDSLFWLTLVPICFSIGASYSKDGGALGIFIALILFNIINIPVKYFGLKYGYT
                     KGSSLIQENNTKGTLNRVTSMATALGLVLVGGLIPSMVGINFGLEFKQGELVISVQEM
                     ITKLIPGFIPMALTLLMCKLIRKGKNPVVLIFSVMAIGVILVVLGILK"
     gene            complement(32072..32845)
                     /locus_tag="VVO18_000452"
     CDS             complement(32072..32845)
                     /locus_tag="VVO18_000452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000899624.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEU5585664.1"
                     /translation="MLFTQALLVTLVGIIATIDYNGPLFMIHRPLVTSAMVGLVLGDF
                     TQGVLIGSALELTWLGVTGIGGYTPPDTISGAIIGTAFGILSGQGETAGIAIAVPIAV
                     ATQQLDVLAKTLDVYFVKKADNDAKNGDYSKIGFYHYSSLVLITLFKIVPIFLAIMLG
                     GEYVADLFAKVPPIVMQGLNSAGALLPSIGFGMLLNMMLKKNMWVFLLIGFICSVYGG
                     MSTIGISLVGIAVAYFYDMIGSKPQETTSSSDVEEDLDL"
     gene            complement(32870..33340)
                     /locus_tag="VVO18_000453"
     CDS             complement(32870..33340)
                     /locus_tag="VVO18_000453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000020992.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5585665.1"
                     /translation="MSIEFVRIDDRLVHGQVVTTWLKKYDIEQVIIVNDRISEDKTRQ
                     SILKISAPVGLKIVFFSVKRFVEVLNSVPIKKRTMLIYTNPKDVYDSIEGNLKLEYLN
                     VGQMSKTEENEKVTGGVALGEEDKYYFKKIVDKGTRVEIQMVPNDKVTMLEKFL"
     gene            complement(33331..33762)
                     /locus_tag="VVO18_000454"
     CDS             complement(33331..33762)
                     /locus_tag="VVO18_000454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483177.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5585666.1"
                     /translation="MFNRGILVASHGNFASGALMTAEMFVGETTNDRVRTLGLMPGEN
                     IVEFEHYFKNQVNELLDSNQEVIVLTDLIGGSPNNVALSRFLNLDSVDIVTGFNIPLL
                     VELISSYDSKINLEEIVQNAQNSLFNVKQQLNVEEEEDLCL"
     gene            complement(33755..34195)
                     /locus_tag="VVO18_000455"
     CDS             complement(33755..34195)
                     /locus_tag="VVO18_000455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000912112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RbsD/FucU family protein"
                     /protein_id="HEU5585667.1"
                     /translation="MLKHIPKNISPDLLKTLMEMGHGDEIVLADANYPSASCANKLIR
                     CDGVNIPELLDSILYLMPLDSYVDSSIQFMNVVSGDDIPKIWGTYRQMIEGHGTDLKT
                     ITYLRREDFYERSKKAYAIVATGETSLYANIILKKGVVVERENV"
     gene            complement(34207..34845)
                     /locus_tag="VVO18_000456"
     CDS             complement(34207..34845)
                     /locus_tag="VVO18_000456"
                     /EC_number="4.1.2.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001286141.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-fuculose-phosphate aldolase"
                     /protein_id="HEU5585668.1"
                     /translation="MSDVKQELIKYGKKLVETDLTKGTGGNLSVFDREKQLMAITPSG
                     IDFFEIKESDIVVMDINGNVVEGERLPSSEWYMHLIQYQTRDDIDAIIHAHTTYATVL
                     ACLREPLPASHYMIAVAGKDVRVAEYATYGTKELAVNAAKAMEGRRAVLLANHGILAG
                     AQNLLNAFNIVEEVEYCAKIYCLAKNFGEPVVLPDEEMDLMAEKFKTYGQRK"
     gene            complement(34960..36363)
                     /locus_tag="VVO18_000457"
     CDS             complement(34960..36363)
                     /locus_tag="VVO18_000457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhamnulokinase"
                     /protein_id="HEU5585669.1"
                     /translation="MEAVLAIDLGATSGRAIVGYLSENKLVMEEINRFSNLPIRVKGH
                     LSWDIDFLLAKILESIRLANTSYKILSIGIDTWGVDFGLIDNEGKLLLQPVHYRDERT
                     KGVLKEISEMTELEKLYSETGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFN
                     YLLTGKFATEKSIASTTQLFDPRSQNWNQNILKLFELDSSLLPEIVSEGNVLGRIKKE
                     YGLGDIPVVNVCSHDTASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGF
                     TNEVGKDGVITFLKNCTGLWIIEELRRSFERRGKAYSFDDIRTMVEKEKENLPLIDTE
                     STEFATESDMHKTLTEYLAYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKV
                     YKRIYVIGGGARASYFNQMIADRTGKEVLTGSTEGTAVGNIVVQLIAMGQLKGMEEAH
                     HVIEEFLQLESYYSQKN"
     gene            36539..37312
                     /locus_tag="VVO18_000458"
     CDS             36539..37312
                     /locus_tag="VVO18_000458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU5585670.1"
                     /translation="MIKDERVLELIEIIKKKKRIAVKELAEITFSSTSTLRRDLIFLE
                     NQGLIKRKHGYVTLSSMNTIELSHQIREGESTRQKRLIASLAKDFIRSGMCIYLDSST
                     TVYELCPYLSELDNLIIFTNGLHTAQTLSETVKDSSKIFITSGEVKHQSCSVVNYDKE
                     NSLLDHFNIDLAFCSARGIDDQYVYEASLSQAISKKNIIDKAHETILLIDSSKFYKTG
                     FFKINPLSKYTTFISDTLPDQKLLDAVELFDGEWVSDIQ"
     gene            complement(38483..39988)
                     /gene="adcA"
                     /locus_tag="VVO18_000459"
     CDS             complement(38483..39988)
                     /gene="adcA"
                     /locus_tag="VVO18_000459"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter substrate-binding
                     lipoprotein AdcA"
                     /protein_id="HEU5585671.1"
                     /translation="MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQ
                     VAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADTFVYENENMETWVPKLLDTLDKK
                     KVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
                     ADYPDKKETFEKNAAAYIEKLQALDKAYTEGLSQAKQKSFVTQHAAFNYLALDYGLKQ
                     VAISGLSPDAEPSAARLAELTEYVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLN
                     PLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAEDTKTVQNGYFEDAA
                     VKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTK
                     INITDNTMEFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFS
                     DHNIAPVKAEHFHIFFGGTSQEALFEEMDNWPTYYPDNLSGQEIAQEMLAH"
     gene            complement(39998..40804)
                     /locus_tag="VVO18_000460"
     CDS             complement(39998..40804)
                     /locus_tag="VVO18_000460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEU5585672.1"
                     /translation="MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLS
                     HVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLRTVYKSFMEIGTAILMSTGLAVS
                     LIVMSKGKSSSSMSLDQYLFGSIVTISEEQVISLFVIAAVVLILTFLFLRPMYILTFD
                     EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKS
                     VMLLASAIGFLGMVAGLYISYYAETPASASITIIFVTVFILISLVRRFIK"
     gene            complement(40797..41501)
                     /locus_tag="VVO18_000461"
     CDS             complement(40797..41501)
                     /locus_tag="VVO18_000461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEU5585673.1"
                     /translation="MRYITVEDLSFYYDKEPVLEHINYSVDSGEFVTLTGENGAAKTT
                     LIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQIASFNAGFPSTVYEFVKSGRYP
                     RKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
                     LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSP
                     WRCFNVHENGQEVGHA"
     gene            complement(41501..41941)
                     /gene="adcR"
                     /locus_tag="VVO18_000462"
     CDS             complement(41501..41941)
                     /gene="adcR"
                     /locus_tag="VVO18_000462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent transcriptional regulator AdcR"
                     /protein_id="HEU5585674.1"
                     /translation="MRQLAKDINAFLNEVILQAENQHEILIGHCTSEVALTNTQEHIL
                     MLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDSKDARVIFYQLTDLAR
                     PIAEEHHHHHEHTLLTYEQVATQFTPNEQKVIQRFLTALVGEIK"
     gene            complement(42096..43364)
                     /gene="dltD"
                     /locus_tag="VVO18_000463"
     CDS             complement(42096..43364)
                     /gene="dltD"
                     /locus_tag="VVO18_000463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000919885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltD"
                     /protein_id="HEU5585675.1"
                     /translation="MLKRLWMIFGPVLIAGLLVFLLIFFYPTEMHHNLGAEKRSAVAT
                     TIDSFKERSQKVRALSDPNVRFVPFFGSSEWLRFDGAHPAVLAEKYNRSYRPYLLGQG
                     GAASLNQYFGMQQMLPQLENKQVVYVISPQWFSKNGYDPAAFQQYFNGDQLTSFLKHQ
                     SGDQASQYAATRLLQQFPNVAMKDLVQKLASKGELSTADNEMIELLARFNERQASFFG
                     QFSVRGYVNYDKHVAKYLKILPDQFSYQAIEDVVKADAEKNTSNNEMGMENYFYNEQI
                     KKDLKKLKDSQKSFTYLKSPEYNDLQLVLTQFSKSKVNPIFIIPPVNKKWMDYAGLRE
                     DMYQQTVQKIRYQLESQGFTNIADFSKDGGEPFFMKDTIHLGWLGWLAFDKAVDPFLS
                     NPTPAPTYHLNERFFSKDWATYDGDVKEFQ"
     gene            complement(43357..43596)
                     /gene="dltC"
                     /locus_tag="VVO18_000464"
     CDS             complement(43357..43596)
                     /gene="dltC"
                     /locus_tag="VVO18_000464"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005591431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltC"
                     /protein_id="HEU5585676.1"
                     /translation="MDIKSEVIEIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVE
                     IENRFDIRVPVTEFGRDDWNTANKIIAGIVELQNA"
     gene            complement(43610..44854)
                     /gene="dltB"
                     /locus_tag="VVO18_000465"
     CDS             complement(43610..44854)
                     /gene="dltB"
                     /locus_tag="VVO18_000465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969717.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-lipoteichoic acid biosynthesis protein
                     DltB"
                     /protein_id="HEU5585677.1"
                     /translation="MMEFFQQLPHLEPYGNPQYFVYVIAATLPIFIGLFFKKRFAWYE
                     VLVSLFFIVTMLVGGKTNQLAALGIYLCWEILLLLFYKHYRKSKDGKWVFYLVSFLSL
                     LPIIFVKVQPAINGTQSLLGFLGISYLTFRSVGIIIELRDGVIKDFTLWEFLRFLLFM
                     PTFSSGPIDRFKRFNENYQAIPERDELMDMLDESVRYIMWGFLYKFILAHVLGETLLP
                     PLKNLALQSGGFFNLYALAVMYTFGLELFFDFAGYSMFALAISNLMGIRSPINFNKPF
                     LSRDLKEFWNRWHMSLSFWFRDFVFMRMVMVLTRKKVFKNRNVTSSMAYIVNMLIMGF
                     WHGVTWYYIAYGLFHGLGLVINDAWVRKKKTLNKERKKAGKAALPENRWIQLLGMVVT
                     FHVVMLSFLIFSGFLNNLWFKK"
     gene            complement(44851..46401)
                     /gene="dltA"
                     /locus_tag="VVO18_000466"
     CDS             complement(44851..46401)
                     /gene="dltA"
                     /locus_tag="VVO18_000466"
                     /EC_number="6.1.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012972622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--poly(phosphoribitol) ligase subunit
                     DltA"
                     /protein_id="HEU5585678.1"
                     /translation="MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDS
                     LAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEV
                     AEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTT
                     GKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGT
                     LFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDG
                     EELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADS
                     PTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMKNPEKTAEAFFEFEGLPAYHTGDVGT
                     MTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLL
                     AYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKG
                     LINEVNKR"
     gene            complement(46422..46553)
                     /locus_tag="VVO18_000467"
     CDS             complement(46422..46553)
                     /locus_tag="VVO18_000467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="teichoic acid D-Ala incorporation-associated
                     protein DltX"
                     /protein_id="HEU5585679.1"
                     /translation="MKQRKELYLFLGRTALYFLIFLGLLYFFSYLGQGQGSFIYNEF"
     gene            complement(46867..48045)
                     /locus_tag="VVO18_000468"
     CDS             complement(46867..48045)
                     /locus_tag="VVO18_000468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071468.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU5585680.1"
                     /translation="MSNSFVKLLVSQLFANLADIFFRVTIIANIYIISKSVIATSLVP
                     ILIGISSFVASLLVPLVTKRLALNRVLSLSQFGKTILLAILVGMFTVMQSVAPLVTYL
                     FVVAISILDGFAAPVSYAIVPRYATDLGKANSALSMTGEAVQLIGWGLGGLLFATIGL
                     LPTTCINLVLYIISSFLMLFLPNAEVEVLESETNLEILLKGWKLVARNPRLRLFVSAN
                     LLEIFSNTIWVSSIILVFVTELLNKTESYWGYSNTAYSIGIIISGLIAFRLSEKFLAA
                     KWESILFPLVAMAIVTLTILYFPNAQMFLLFSALVGMLSQLKEVPESVFLQETVEENH
                     LVNVYSVLEVISTLAFSVFVLLMSYITESFGISISFWLSAICLMIEAILIYIRRDYFK
                     "
     gene            complement(48505..49782)
                     /gene="ltrA"
                     /locus_tag="VVO18_000469"
                     /pseudo
     CDS             complement(48505..49782)
                     /gene="ltrA"
                     /locus_tag="VVO18_000469"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040325.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
BASE COUNT        15009 a        10989 c         9150 g        15314 t
ORIGIN      
        1 tctcaccttt taaaagaaat tattgggctg aaagttttta gtaattattt tcaactttct
       61 attgactttt aaaaacaaag tgatatcatt tagatatcaa ataatgggag gtcattctta
      121 tgactgaaaa actaatcaat tcaaaaccaa atggtgtatt cgcattgatt ctcattgagt
      181 tgacaatcgt acttggtatc tttatattta taatgggtgt tggttcggaa aacatttttg
      241 gaattattat cggaccttta ctaatcgtaa ttgcaggtct agctcatgct ggtttaaaag
      301 ttgtcaaacc tcaggaagct ctggttctga cactctttgg taattataca ggtaccatca
      361 aagaacctgg tttttacttt gtcaatccct tcagcgtagc agtcaaccct gcaaaccaca
      421 ctcgacttgg acaaagtggt gatgttagca caaaatctcc ttttttagga gctaaatcat
      481 caaatgacaa tgatgtaaat cttgaaattg gcaagaaaca gatttccctc aaagtcatga
      541 ccttgagcaa ttctcgtcaa aaaatcaatg attgcttagg aaaccctgta gaaatcggta
      601 tcgcggtaac ttggagagtt gtcgataccg ctaaggcagt cttcaacgtt gataactaca
      661 aagaatatct ttcattgcaa tgtgatagcg ccctccgtaa tattgtccgc atctatcctt
      721 acgatgtgtc tcctaatgtg gatactacgg gtgacgggca agcagatgaa ggtagtctcc
      781 gtggctctag cgaaattgtt gctaaccgta ttcgtgaaga aatccaaagt cgtgttgagg
      841 atgctggctt ggaaatcctt gaagcacgta tcacttacct agcttatgct ccagaaattg
      901 ctgccgttat gcttcaacgc caacaagcat ctgccattat tgatgcacgt aagatgattg
      961 tagatggtgc tgtaggaatg gttgaaatgg cactagaacg gctcaatgaa ggggaattgg
     1021 tagaacttga cgaagaacga aaagctgcca tggtttcaaa tctccttgtc gttctttgtg
     1081 gcaatcatga tgcacaacca attgtcaaca caggaagtct ttactaaaga tggctgaggc
     1141 taaaaaaaag cagatccccc ttcgactctc aacaaagtta tacgctgcac tcgcatcatg
     1201 ggcagaagac gactttcgtt cagtcaatgg ccaaatcgaa tatctcctca cagagtgtgt
     1261 caagcaacgg aagaaagacg gaaaatacgt atcagaaacc attgacgaac catttgagat
     1321 tgatatttaa caccttctcc tgtctgccgt gtcggatagg agaatttttt catctttttt
     1381 tgtcaagtaa ctttacttta caaaaaaaat gtgttatcct agtatggttg atgaaaatca
     1441 gtagattgaa tcgaatataa atacctaaag gagaaatcaa aatggcagta cctgcacgtc
     1501 gcacttcaaa agcgaagaaa aacaaacgtc gtacacacta caaagtaaca gctccatctg
     1561 taaactttga cgaaactact ggagattact cacgttctca ccgtgtatca cttaaaggat
     1621 actacaaagg acgtaaaatc gctaaagctg tatcagctga ataatagaag ggagatacca
     1681 tgcgcgtaaa tattacactt gaacacaaag aatctggtga acgcttgtac cttacttcta
     1741 aaaacaaacg taacactcca gaccgccttc aattgaagaa atactcacca aaacttcgca
     1801 aacacgttgt gtttacagaa gtgaagtaag cattcaatac gaatcaatac agaagaaaaa
     1861 cgcttgatca gcgttttttc tttttgttaa tttcactata ttgcaaggga aatcattcga
     1921 atgactacat tattgataat atttgttaag ccatcaaaag taattaacat ttcatagcga
     1981 gtaatcctat ttaaactcgt cccactatct atttcttctt atctctgtgt tataatcccg
     2041 actttatcat aagtttgtct aactgtagca tttgaaacca gataattctt ctgtttcacg
     2101 cgaaacaccc tgcgccaagc aaggtgttct tgtttttata ctcaatgaaa atcaaagagc
     2161 aaactaggaa gctagctgca ggctgctcaa aacactgttt tgaggttgta gatggaagct
     2221 gacgtggttt gaagagattt tcgaagagta ttaagtcgta taaatcgtcg acgctgtcgc
     2281 aatggtatgc cactggttag ctgtagttgc tgcgaagtcc ttgtctgcgt agaagtcagt
     2341 aaatggtagg atttcaactt ccagctcgtc gatgcggtca agctgaccag ccagataaac
     2401 ctcgatacgg ctttctgctc gtttgatgcg ttgcaagagt ccgcccatac ggatgtcaac
     2461 tgtatccaaa ccaaagacct tgttttcttt cagccattgg tggctaaaga gggcatggaa
     2521 gtcttcaatt tggcttctaa gttctggtaa ttcttgtctg gcgatttgtt gtaaactttc
     2581 tttatcatcc gcttggtagg cctgacgaat gcgtcgtccc acatctactt tgctacttaa
     2641 aatagcattc aactgggcct gagtttcaaa gagataagca tagtttccag ctttttcttt
     2701 aatgttagca agcgtctcag cagcctgagc gaagtgcggt ttgtcctgtt caggtgtcat
     2761 gtgttgatca agaatcggac aaagaacatc ctgataaaaa acatagcggt tgggattgat
     2821 accgctgaga ttgcctggta ggtctggtaa gaggttggca aggtcaatct gcataaaatc
     2881 ctcaaccgtt agaccagtat tggtcttgaa gtgcgcagac aaaccatcta ggtcattgcg
     2941 atagctgagt tctgcccaga tttgcaagct tggtaggata gagaactggg cagtttcacc
     3001 accattgtct ccccaacccg ttacgatgac ttctttaatc tgattggcac ggcaggcttt
     3061 attagcctcg atagccacta gacggctaaa atggttgtga ggtgtaaagc caatccactt
     3121 ccaagctccc cctgcaaatg caaggtcatg gctaatcttg tgatgattgc ggaaattacg
     3181 gttgtatttt tcctcgctat cctgataata atcccagtaa accagagtca cacggtcttt
     3241 gagacggtct aggtagacac gagtttcctc tggaatttcc acatcacggt cgtactggcc
     3301 atccgctgac atgagtttga agaacatatc actccacatc tggcagtgga aaccatattt
     3361 gtcagcaata tccagcacgc gctccaagtg ttggcacatg aggagactac gatccacaac
     3421 accgttcaaa atcaggtagc gtcccaaacc aaccaagtgg gcttcgtcca tcccgatatt
     3481 gaccttgcga gtcttcagtt tagacaacgt ggcaaacatg ccatcaatca ggtcataaac
     3541 cttttcttcg ccaatgagaa gaatgtcctc tacatcacgg agctcctgca cttccttgac
     3601 accccatttg acaaaggccg acaagtgggc caaggtctgg atgcatggta caaaggtcat
     3661 gtcaaactgt tgagcatagg cttcgatttc ctgcaactcc tctgctgaat aagctccacg
     3721 gaaatagcca aagtaaggct gcccttcaat ctggtaagtg tcttccatgt aaagctcaaa
     3781 ggttgagtag cccatgagag ccaagacctc aatcatctgc ttggcagaag ccacattcag
     3841 caccgcattt cgagaacagt caaccatgta agccaaatct tcgtaagctg cttgttcctc
     3901 aatctctact ttatcagctt ctgctagaac tgttaccaac aaggacaagg cacgatagag
     3961 ttggtgaggt ttgcggtagg tcaattgata gtgaccttcc tcaccctcga tagagataga
     4021 ggcttggtca gactgagtga cagccacttc cacatctggt agagaaatgt gaccttttaa
     4081 aacctcaata gcttgcgttt gtttgggact aagtcctgta aatcttacca ttgcttttcc
     4141 tcctgtagcc agttgacaag agcaccgtag agattggcat ctgcgtgata ggtgcaggcc
     4201 tggataactg gtgcgaccgt gtattcttcg taggcatcga caaagtcttc aacagccttc
     4261 ttaacacctt ggataaaatc tggattttga ctgatagagc cacccagact gatgacatct
     4321 ggatcgatca gatactggat attgagcaag ccttgcgtca gattgcggtt catgcgctca
     4381 atggcttctt gacaaagagc attaccagct gcggcctctt ggtaaatctt gcgaccgtcc
     4441 caatcagtat gaccagattt ttcaatcacg tatcgtacca tattcccagt tgatgctagt
     4501 tgcgaccagt tattaagttt ttcagcaggg gcaagggttg tcatgtagcc aaattctcca
     4561 cccaagccgt ggcgacctcg atgaagtcta ccattgataa tcatggctcc gccaatccct
     4621 gtcccaatca cgacacaggc tgcattttca agctctggat gagctagtag ttcactgagt
     4681 ccaacgcagt tggcatcatt ttctaaatgg acaggtagct gataagagct aagcgcctca
     4741 taccaagaaa agccatggat gtagggcacc gcactgaagc catcaatcac acctgtctct
     4801 tgattgaccg cacctggaac gctcatagca atcccactgt aatcctgttc tgacaagcgt
     4861 tgatctagcc acgctagtaa atcctccaag ttttcaggcg ttgaaatact tgtcttatcc
     4921 agtattttcc catcaggagt cagactggca aacttaatcc cagtccctcc gatatcaatc
     4981 gttgcaatgg tcattgtttt taccataaaa aggggcgaat cagcagttag ttcttacctt
     5041 ttcgcccctc ctttcttttg atgtttactt tttgaaatta aatttcttct tttttgatga
     5101 attctgtacg aatctcttgt ggagccaata gtcctgaatg aactggatat ggtcgctcaa
     5161 gtaagtcaag aatggtttgt tgatgttctg atatgcgcac attttcttga ctcatattat
     5221 agtaacggag gacatagcct tcttcatttt ccgccacttt aaaggctgtt ggacaaactt
     5281 gcggtatgct gagaacagaa tggctcaaga ggctaccagt cgcaaccacg cttccttcct
     5341 gtctagaaag ctgaaggctg gtaaacggtg tctgcaaggc tttggcacga cgataggctg
     5401 agaagcgttc ttgggcttgg tggcattcaa tcgcaaattc gacttcaaac tcacgcaagc
     5461 attgtgcttc tggcgttggg aagtagcccc agtcacctag ctcacctgat gcacgcaaaa
     5521 tggtcacggc aatggtgtta tccccaagga tttcgtattc attcaatccc ttgttggata
     5581 cagtcacacc tttttcatcg tcatacagac tgacaaaagc ttgttggtgt tgaggatttt
     5641 caggattttc ccatgaagca gctggtttgt ttggtcgtgt caccacctca tagatacttt
     5701 cagaatcatt gcttggacgc gtgttatgag tcttgaccaa gagacggata cggtgatcct
     5761 tggcagtgtt agtaaagcga gtcttgaagc ggatttgtgg attgtcaacg aagacagtca
     5821 actcagtttc cagaggaatg tttgtcaatt cttctgaccg tccagcctca cgcttcataa
     5881 actcgatgat accttgttgc tcttcttcta gcttttcatc cgcgctgaca ggcacggtca
     5941 attcatgttt gagcaagatt ttagcatagc aagctgtgtt ttccaagacc tcgtggccct
     6001 taagctctgc aaagattggc tctgttcctt ttggttggaa atagatatac tcgtttccga
     6061 tgtccccacg gtcttcaaag cggataaagt cttcataggc ttcgtgagtt gtcttgtcat
     6121 agactgtgat gttgtcatcc acactcaccg ttacgaatgg tgtatcaatc actccgtttt
     6181 ggtaaatacc ctcacggtgt tcttgttttc cttccagcaa ttggaaggtt gtccaagaaa
     6241 gcggcgctag gtgaactgga atggtcacgc gcacttgacg agcaatacga gcttggcgga
     6301 acttgtcttt tggtaaatca tactcaaaat tagctccgag gtcttcgatt gtagcctcta
     6361 caggatgacc atccaagtcc tccacacggt aacttggcaa gataagagca gccatctttt
     6421 tgtagccttc tgttgggtgc aattccttga aatcacaagt cgccacatca atcactgtgc
     6481 tgacagtatc gaccttatca tgcaagcctg tgttaatgac agtaaagaga tagtcacttt
     6541 gagccttatc cgtagcaatt ttacccttcc actcgttgag caagttactt ttaacaaagt
     6601 ttcctacttg gttgaccttg gcaaaacgcg tttccatctc gcggtgaact tcgtccacgc
     6661 tacagccaca gatactatca tgtggcgcgt tctgcaaaag tgttttccaa gcataggtca
     6721 actggtcctt gtggttgtgt ccaccagtga taatagtcaa gggttctacc acttgctcta
     6781 ggaggttgct attttcttgg aaggcttgtt ttaggtaaat gcgggatgaa gaagtgttgg
     6841 caagtgtgta ccagccatct gtttcctgac tggtcaactc acctgtaaca gttgataagt
     6901 gttcaggaag cgcaccttct acagcttgaa catattcatc aaaagaacta tgaacaaaga
     6961 ttacatctgg gaagagttca tttgccacac gaatggcttc gctcagattt ttctgtacag
     7021 gctggtggtc acagccgttc atcatcaacc attggttggt cgaagcgtag gcacgcacat
     7081 ctgacaattt ttgtttccag aaggtcaagg cctcatcttt gtcaactgga atttcattcc
     7141 cgttactgta ccagttggca aagagaatac ctaaaacacg actaccatcc acaccctgcc
     7201 agtacatttc tgaaaactgg gatgtaaact gctcatcttc aaggacttgg ttgtcaaatc
     7261 caatcggctt cacaccacga ccaaaggccg ccacgtgaat gcctgatttt tgaagaattt
     7321 gaggcgcttg tcccatattt ccaaaggtat ctggaaagta gccaatctgg gttgatttac
     7381 cccatttggc agcttcttgt tgaccaatca aggtattgcg gacattggct tcactggaga
     7441 tcaagtagtc atcctgcaag atgtaaaagg gaccaatttt aagtttgccc tcgtcaatgt
     7501 agcgttggac cttgtcacga ttttcagggc gaatttgtaa gtagtcgtca aggacaatag
     7561 tttgtccatc caagtggaaa ctcttgaact cagggtcatt ttcaaagaga tcaaagagat
     7621 tgtcaaacaa ttccaccaac tgcatacgat ggctttcaaa aggcaagtac cactcacggt
     7681 cccagtgact atgtgagata atatgtacaa caacattttc catgaagtaa aacctcattc
     7741 taaatttaaa ttttaacgtt ttaaatgtaa acttgtgatt ctgataagaa tcggttgagc
     7801 taaagcgagc cccttagcga atatccaagt aatccaagac caactcacag aacatcatgt
     7861 tagcccagga gaaccattca cgagagtaga gggtcggatc atctacgtgg aagctttcgt
     7921 gcatgacacc tgtaccacca tcgcaggcaa ccagctgatc cagcaagaat tttttctctg
     7981 ccttatctct tgttgtcaat ccttggatag aaagggcgat tggccagata tagcgataga
     8041 aggtatgaga acttccgaga ccgctagcgt attctccttg gtagaagtat ggattttcag
     8101 agctcaaaat ggtacgacga gtagcttgat acacttcatc atcgaccgaa cagtagccca
     8161 gatagggcgc agctagtaga cttggtacat ttggatcatc catgatgctg gcatttccta
     8221 ggccatccac ttcaaaagcg taaatctttt cgcccttgct gttggtggtg taagcgtagt
     8281 tttcgattcc ttcttggatt tcatcctgaa gacgcttggt atcagcaata acactctggc
     8341 tatcagctag gtttaatgct gcgaagattt cttgcacata acccaagact actacagcaa
     8401 acatatttga cggaatcaag taactatact ggcaacagtc atcactcgga cgaaaggctg
     8461 accaagtcat acctgtcact gcaaagtcag gtccaaagcc atcatttacc aaggtgtctt
     8521 ccttacggtc cgtatctcgg acaaaacgat aaggagagtt cttgtggtct tgttcaactg
     8581 tccatagatg gagaatttcc ttagtcgctg cgacaaaagt ctcatcaaac tgaccagtct
     8641 cgccagtctc tttccagaga agataagcca actgaaaagg atagcaaagc gagtccacct
     8701 catacttgcg ttcccaaatc cagccattaa ggtcggtgtg gtcggtctcg tggtgcccct
     8761 tccagttttc ctctatgttg aaggaattgg cataaggatc cttgagtacc aaggtcatct
     8821 gacgtttgac caaacctgca atggtctgac gcaggaggga atctctttta gccacatgca
     8881 ggtagggtct gagttgggct gtcgaatccc gaagccacat agcaggaata tccccagtca
     8941 agacaaaagt tgaaccatct tctaagattt caaccgtatt gtccaaggta tcggtgtagc
     9001 aacgctcaaa gacatcaacc cactctggat ggtccttggc ccgctctgct acttcatcca
     9061 gccactctct gacgatttct ttcgaataaa tcatcgtgca attccctctt tcaaacaagt
     9121 ttcatgttca gtatatagct tttgagacag aaaatacata cacaaatgat agtcattttt
     9181 ctacaaaata gttatttttg aaactccttt tctaaaggcc ctctttttct gatataatgt
     9241 agaaaaacag ctaaaggaaa gactatgaaa ccactacttg aaaccatcga tacccgcttt
     9301 ggaactacca acaagcatgc cttttctcgg ggaaataccc tgccatacac aggcgtgcct
     9361 tttgggatga attactttgt gccccagacc agtgaccagg atggatcttg gttttttgat
     9421 ccgcatctgc ctatctttca ggggattcga ttaactcacc agcccagtcc ttggattggg
     9481 gactactctt ggctccttct gacacctgtc accagtcaac tggggggaga cagcctcttt
     9541 caccgccagt cttcttatga tatagataaa gcttgcttcc agcctcacta tttgaagctc
     9601 ttttctctgc gttatcagat tgaaacccag ctcacaccga cttgctatgg tgcttctatt
     9661 cgtttgaatc aaaagcaagg caaagccctc tccctctatc ttcacgcagc agatgaactg
     9721 acagtagagc aagtagataa gcggactctt gccctgcgac aagaaggtaa aactgaaact
     9781 aacaaaaatt cgctaacgat gttcactgcc ctgcaaatga acacggatat tcttgccatc
     9841 agccaagaag ctggagactg gcgaattgac ttagcaagta gtcaaaccga gatgcaacta
     9901 gccacttctt tcatctctcc ttctcaagca ctgcttaatc tacctcaaga agattttgat
     9961 agctgtaaat caagtgccca agcggattgg gaaaatctcc tccatcgttt tgacattata
    10021 gagataggag aggctgaccg aaccttcttt gaccactgcc tctacagact cttcctcttc
    10081 ccacagactt tttatgagat taatgaatca gggcaagcca tccacatgga tctggctact
    10141 ggtactgtca agcctggtgt cctctttagc aacaatggtt tctgggatac cttccgcacc
    10201 accttccccc tctttgccct tatcataccg gagcactatc aacgcttttt agaaggtttc
    10261 ctcaatagct accgcgatac tggtttcctt ccaaaatggc tggctccaga tgaacggggt
    10321 atgatgccag gtacactttt agacggtatt atcgcagata gcgcctgcaa ggacatggcc
    10381 cctgacctag aaggagaact cttccaagcc atgctcgaaa cagccagcaa agccgaccct
    10441 ctcggaatca atggccgcca cggactagcc caataccaag aactaggtta cctctctacc
    10501 gaccaccacg aaagtgttag ccatactcta gactatgcct atagtgactt ttgtatcgcc
    10561 agctgtgcca aaaaactaga gaacatagaa atcgctgaaa cctacaaggc tgcttcacaa
    10621 aattaccgcc agctatttga cgctgagaca ggttacatgc gagcacgaga caatcaagga
    10681 aactttcacc ctgacttctc tccttatagt tgggggcgag actacgctga atgctctgcc
    10741 attcaagcta ctttaggcgt tctccacgac atccctggct taatccaact gatgggtgga
    10801 aaagaaacct ttagcaacta tcttttgaaa gcctgtcaag atgctcccct ctttgaaaca
    10861 acaggctatg gttacgaaat tcacgaaatg agcgagatgg ctactgctcc ttttggacaa
    10921 atagccattt ccaaccagcc tagtttccac attccttatc tcttccgcta cagcgattac
    10981 cctgactaca ctgcccttct tatcaagacg ctccgtcaga aagcttttca cccaagttgg
    11041 gaagcctatc ctggagatga agacaatggt agtctctctg cttggtacat ctggtcagct
    11101 ctcggatttt atccaacctg tccaggaaaa ccaagctatg acctcggaat ccctctcttt
    11161 gaccatctac gagtctacct cgctaaagaa gataaatggc tggatatcca tactaaacaa
    11221 aaccacaacc attttaactt tgtcaaagaa tgccgactgg acaaaacact cgtatcaact
    11281 attcaacacc aagacctctt aaaagctgaa caactaactt tcaccctcag ctggttacca
    11341 agtcactaat aaccaaaaga acctttgcat cgcgcaaagg ttcttctttt atgaaacttg
    11401 gacttgaagt tgatccacaa gctgaccatc caccgttagg ttcagataga aatccaaggt
    11461 tttatctcct gcgaaataca gggttggtag atgcaaatct tttttgcttt cccctgcttg
    11521 gaattgaagg acttgaatct catcctgata ggcgacacca tggacacctg tccccggttg
    11581 aatcgaaatc ttagcctcta aagaggagct actttcacta cgttcaatcc taaaatgaag
    11641 agtctctccc tttgccacag ctaggctttt ttctgcaaat gctagcccct gaacagctac
    11701 tgtttgtgat aacctcggag ttttatagag tgaaatcttg gtcaacaaag gcaaagcctg
    11761 tgattctgta atgactacac gtatcttctg tgcttcaaca actgctcctc gtaagagacg
    11821 tttgtaacca acagtatgac ccgaaccaaa ctcctgccag acaccatcca cctctacttg
    11881 cacatgaaaa gcagcgattc gttgccctag cttcaaatct tctcttaact caattacatc
    11941 aaaagtttta ggagaaccta agtcgagttc taactggatg ggcaagtctg catcgtttgc
    12001 ccaagagctg gtctcaaggt cgtctgtcaa atggcgacaa gcaaagtctg cggaaagagc
    12061 tggaccagat acctcagctc ccagagccaa atcttcttta tagagctcat tgcgataggt
    12121 cgcaaattca taaagtcgtt caatatcctt tgcatcaaag agcccagctt gattcggcgg
    12181 aatattaagc aagagtggag ttcctcgccc tactgagtaa aagtagattt cgaccaactc
    12241 ctcgagagac ttaggatcct gatcctcatg gtagaaccag cctggacgga tggaaacatc
    12301 tgcctctccg attgaaaaaa tcgtgcccga gggatccccg tgctgaagat agttcagctc
    12361 tgcttctgtt cctagtttat caggattcac cttttgccac agtggatcac ctgcataccc
    12421 tcgttcattg ccaatccagc ggatactggt gccttctgtt gaaaaaatca agcaagcgcc
    12481 ctgcaggtca cgaatggttt caaaccattt ttcaaattca taattaacct tttgcgcgcc
    12541 ctctcctctg gcaccatcca tccaaacctc agcaaatttc cctccatttc cataggcagg
    12601 atttgataag atttccttca gctgagccag ataataggca ttgtagtccg cttctcggtc
    12661 cacatgatag aggggactat gggcatccca cggtgacagg tagaccccca tatccatatc
    12721 aaactctgtg gcagcttggg atacttcaag gagcaagtcg ccctttcctc tcctccaagg
    12781 actgacctta accgaataat ctgtgtgagc tgtcggataa aggacaaagc catcgtggtg
    12841 cttgaccacc aaaatcaact ttttgaagcc cgtttccttg agcacacgaa cccactcacg
    12901 cgcatccaac tgactcgggt taaagcgctc aggatcctcc tgtccagtcc cccattcttg
    12961 gtcataaaag gtattaggac cgaagtggat aaaagctgct agttcatctc ccagataagc
    13021 tagctgagtc tgacttggta acggtccatg cggtttgatt ttcttcatcg ttatatatct
    13081 ccttctttag caacttctct tgttcacaag gttatccaca ggttgtggat aataaaccat
    13141 gatctaacag ccagctcttt ccaactccaa ctggtaggct caggattttg ctcctcaata
    13201 ttccctcttc aaacagctct gtcatatggt tctgctaaca cctctcagaa tgctactctc
    13261 cataattatt ctcaggcttc tttcaggtca ttgtgtgaag accattcact ctccagactt
    13321 ttccacagat tgtgaataag tgattattct aaactatcac ctcgtcgact ataacaaaaa
    13381 ataaaaagag ggtcaataag ataattatct cttcctaaat actcagaaaa gattctataa
    13441 tttgtacaat tgaacaagaa atgcttctcc aaaatctatc ttcaaaagaa tgttgcatct
    13501 ttttatcctt tcacacaaac atttctcttt atacagatcc aagtgataac cagatgataa
    13561 ttggacactt tttggttatt tgtgtatttt ttgaaaaatt ttttaaaaaa attttatatc
    13621 ctctttaata gaagtttatg catttgtata tatgtattcc atcctatgtt gtgtataata
    13681 acataaaatt gtgctaaata tcataattta tattattttc cgagaaatta tagccattga
    13741 cattacctag gaattgcgtt ataacataca tgtaagcggt acccaaaatg gtgccaagtc
    13801 aaaattttta aggaggaaaa tacatgtctt cacatccaat tcaggtcttc tcagaaattg
    13861 ggaaactgaa aaaagttatg ttgcaccgtc caggcaagga gttagaaaac ttgttgccgg
    13921 actatcttga aaggcttctt tttgatgata ttcctttctt ggaagatgct caaaaagaac
    13981 atgatgcatt tgcccaagct cttcgcgatg aaggaattga ggttctctac ctagaacaac
    14041 tcgctgctga atcattgacc tctccagaaa tccgcgatca atttatcgag gaatacttag
    14101 acgaagccaa catccgtgat cgtcaaacca aggttgctat tcgtgaattg cttcacggca
    14161 tcaaggacaa ccaagaattg gttgaaaaaa caatggctgg gattcaaaaa gttgaattgc
    14221 cagaaattcc tgacgaagct aaagatctaa ctgacttagt tgaatcagat tatccatttg
    14281 caattgaccc gatgccaaac ctctatttca ctcgcgaccc atttgcaaca attggaaacg
    14341 ccgtatcgct taaccacatg tttgcagaca ctcgtaaccg tgaaacactc tacggtaagt
    14401 atatcttcaa ataccaccca atctatggcg gaaaagtgga tttggtctac aaccgtgaag
    14461 aagatacgcg tatcgaaggt ggagacgagc tagttctttc taaagacgtc cttgcagtag
    14521 gtatctctca acgtacagac gcagcttcta tcgaaaaact tttggtcaac atcttcaaga
    14581 aaaatgttgg cttcaagaaa gttttggcct ttgaatttgc taacaaccgt aaattcatgc
    14641 acttggatac tgtcttcact atggtagact atgacaagtt cactattcac ccagaaatcg
    14701 aaggcgacct tcacgtttac tcagttactt acgaaaacga aaaacttaaa atcgttgaag
    14761 agaaaggtga cttagctgaa cttcttgctc aaaaccttgg tgtagaaaaa gttcatttga
    14821 ttcgttgcgg tggtggcaat atcgtagcag ctgcgcgtga acaatggaac gacggttcta
    14881 acactttgac catcgcacct ggtgtggtag ttgtttatga ccgcaatacc gtgaccaata
    14941 agattttgga agaatacggg cttcgcttga ttaagattcg cggaagtgaa ttggttcggg
    15001 gccgtggtgg acctcgttgt atgtctatgc catttgaacg tgaagaagtg taatcgctgt
    15061 tcggtattcg tcaatagaaa atgtaaaaaa tagaaagagg aaataataaa atgacaaatt
    15121 cagtattcca aggacgcagc ttcttagcag aaaaagactt tacccgtgca gagttagaat
    15181 accttattgg tctttcagct cacttgaaag atttgaaaaa acgcaatatt caacaccact
    15241 accttgctgg caagaatatc gctctcctat ttgaaaaaac atctactcgt actcgtgcag
    15301 cctttacaac tgcggctatc gaccttggtg ctcacccaga atacctcgga gcaaatgata
    15361 ttcagttggg taaaaaagaa tctactgaag atactgctaa agtattggga cgtatgtttg
    15421 acgggattga attccgcgga ttcagccaac gtatggttga agaattggca gaattctcag
    15481 gcgttccagt atggaacggt ctaactgacg aatggcaccc aactcaaatg ctcgctgact
    15541 acttgactgt tcaagaaaac ttcggtcgct tggaaggctt gacattggta tactgtggtg
    15601 atggacgtaa caacgttgcc aacagcttgc tcgtaacagg tgctatcctt ggtgtcaatg
    15661 ttcacatctt ctcaccaaaa gaactcttcc cagaaaaaga aatcgttgaa ttggcagaag
    15721 gatttgctaa agaaagtggc gcacatgttc tcatcactga agatgctgat gaagcagtta
    15781 aagatgcaga tgttctttac acagacgttt gggtatcaat gggtgaagaa gacaaattcg
    15841 cagaacgtgt agctcttctt aaaccttacc aagtcaatat ggacttagtt aaaaaagcag
    15901 gcaatgaaaa cttgatcttc ctacactgct tgccagcatt ccacgatact cacactgttt
    15961 atggtaaaga cgttgctgaa aaatttggtg tagaagaaat ggaagtaaca gacgaagtct
    16021 tccgcagcaa gtacgctcgc cacttcgatc aagcagaaaa ccgtatgcac actatcaaag
    16081 ctgttatggc tgcgacactt ggtaaccttt atattcctaa agtataattt tagataataa
    16141 accgtctacc aacagctatg agggctgcga ctaatagctt tagtccggtc ctcttttatg
    16201 taatggtaat ctattatttc ttataaaata tgtgaaaaat cattaaattg aaatctaaac
    16261 gcattctatt gagtgtgata aaggagaatt tatggcaaat cgtaaaattg tagtagcttt
    16321 gggaggaaat gcgattcttt cttctgaccc atcagcaaag gctcaacaag aagctttagt
    16381 tgaaacagct aagcatcttg taaaattgat taaaaatgga gatgatctga ttatcactca
    16441 cggtaatgga cctcaagttg ggaatctctt gctccaacat ttggcatcag actctgaaaa
    16501 gaaccctgcc ttcccactcg actcacttgt cgctatgaca gaaggtagca tcggtttctg
    16561 gttgaaaaat gctttgcaaa atgctctctt ggatgaaggc atcgaaaaaa atgttgcctc
    16621 tgttgtaacg caagttgtcg tagataaaaa tgatccagct tttgttaact tgagtaaacc
    16681 aatcggtcct ttctattcag aagaagaagc aaaagcagaa gccgaaaaaa gcggagcgac
    16741 tttcaaggaa gatgctggcc gtggctggcg taaggtcgtt gcctcaccaa aacctgttga
    16801 catcaaagaa attgaaacca tccgtactct tttaaataat ggtcaagtcg tcgtagctgc
    16861 aggtggtggc ggtattcccg tcgtcaaaga aaacaatgga catttgactg gtgtcgaagc
    16921 ggttattgat aaagacttcg cttcccaacg tttggcagaa ttggttgatg cagacctctt
    16981 catcgttttg acaggtgtag attatgtatt tgttaactac aacaagccaa accaggaaaa
    17041 attggaacat gtgaatgttg cccagctgga agaatatatc aaacaagatc agtttgcacc
    17101 aggtagcatg cttccaaaag tagaagcagc tatcgctttt gtcaatggtc gtccagaagg
    17161 aaaagcagtt attacttccc ttgaaaatct aggcgccttg attgaatctg aaagcggaac
    17221 aattattgaa aaaggataag ttgttttact aataagatgt attctatttc tagtatcttt
    17281 atatcaaatt agaaattatt cttgaaaaca tgtacaatat ttcaaaagat attagttttt
    17341 tagactttaa tatggtaaaa caaatataaa tagaaagcgt tttcttaaat gtttatttaa
    17401 gaaagtagtt ggttttttac actttgttag acatcaggag gaaaaacaaa tgagtgaaaa
    17461 agctaaaaaa gggtttaaga tgccttcatc ttacaccgta ttattgataa tcattgctat
    17521 tatggcagtg ctaacttggt ttatccctgc gggggccttt atagaaggta tttacgagac
    17581 tcagcctcaa aatccacaag ggatttggga tgtcctcatg gcaccgattc gggctatgct
    17641 aggtactcat ccagaggaag gttcgctcat taaagaaacg agcgcagcga ttgatgtagc
    17701 cttcttcatc cttatggttg gggggttcct tggcattgtc aacaaaactg gtgctcttga
    17761 cgtagggatt gcctctatcg tgaagaagta taagggccgc gaaaaaatgt taattttggt
    17821 actgatgcct ttgtttgccc tcggtggtac aacttatggt atgggtgaag aaacaatggc
    17881 cttctatcca ctccttgtgc cagttatgat ggccgttggt tttgatagcc tgactggtgt
    17941 tgcaattatt ttgctcggtt ctcaaatcgg ctgtttggca tctactctga atccatttgc
    18001 gacaggtatt gcttcagcga ctgcgggagt tggtacaggg gacggtatcg tacttcgtct
    18061 gatcttctgg gttaccttga ctgctcttag tacttggttt gtttaccgtt atgcggataa
    18121 gattcaaaaa gatccgacta agtcactggt ttatagtact cgcaaagaag atttgaaaca
    18181 ctttaacgta gaagaatctt catctgtaga atctacactt agcagcaaac aaaaatcagt
    18241 tctcttctta tttgtgttga cattcatctt gatggtattg agcttcattc catggacaga
    18301 ccttggcgtt accatttttg atgactttaa tgcttggttg actggtcttc cagttattgg
    18361 taatattgtc ggttcatcta cttctgcact aggtacttgg tacttcccag aaggcgcaat
    18421 gctctttgcc tttatgggta tcctgattgg tgttatttat ggtcttaaag aagataagat
    18481 tatctcttcc ttcatgaatg gtgctgctga cttgctcagt gttgccttga tcgtagcgat
    18541 tgctcgtggt attcaagtta tcatgaacga cggtatgatt accgatacaa tcctcaactg
    18601 gggtaaagaa ggcttgagcg gtctatcttc acaagtcttt atcgttgtaa cttatatctt
    18661 ctatctacct atgtcattct tgatcccatc ttcatctggt cttgccagcg caactatggg
    18721 tatcatggct ccacttggag aatttgtaaa tgtccgtcct agcttgatta tcactgctta
    18781 ccaatctgct tcaggtgtct tgaacttgat tgcaccaaca tctggtattg tgatgggagc
    18841 tcttgcactt ggacgtatca acattggtac ttggtggaaa ttcatgggca aactcgtagt
    18901 cgctattatt gtagtgacca tcgcccttct tctccttgga accttccttc cattcctata
    18961 aaatagtgag tgaggtgatt ccatgaaaat agatataaca aatcaagtta aagatgaatt
    19021 tcttatatca ttaaaaacct tgatttccta tccttcagta ctcaatgaag gagaaaatgg
    19081 aacacctttt ggacaagcaa tccaagatgt cctagaaaaa actttagaga tttgtcgaga
    19141 cataggtttc actacctatc ttgaccctaa aggttattac ggatatgcag aaatcggtca
    19201 gggagcagag cttctggcca ttctctgtca tttggatgtt gttccatcag gtgatgaagc
    19261 agattggcag acaccgccat ttgaagcaac tatcaaagac ggctgggtat tcggacgtgg
    19321 tgtccaagat gataaaggcc cttcgctcgc agctctctat gcagtaaaaa gcttgctgga
    19381 ccaaggtatt cagttgaaaa agcgcgtacg ctttatcttt ggtaccgatg aggaaaccct
    19441 ctggcgctgc atggcacgct acaataccat cgaagaacag gccagtatgg gctttgcacc
    19501 tgactcatct tttcctctga cctatgctga aaaagggctt ctacaggtca aacttcatgg
    19561 ccctggatcg gatcaactag agcttgaagt aggaggcgcc tttaacgttg taccagacaa
    19621 ggccaactac caaggtcccc tctatgaaca ggtttgtaac gatctcaaag aagctggtta
    19681 tgattaccaa tccactgaac aaaccgtaac ggttctcgga gtgccaaagc atgctaagga
    19741 tgctagtcaa ggtatcaatg ctgtcatccg actagctacc attcttgctc ctctccaaga
    19801 acaccctgct ctcagctttc ttgcaacaca agcaggtcaa gacggcacag gaagacaaat
    19861 ctttggtgat atagcagatg aaccttctgg tcacctatcc tttaatgtcg caggtctcat
    19921 gatcaatcat aaacgttctg aaatccgtat tgacattcgg actcctgtct tagctgacaa
    19981 ggaagaacta gtagagttgc ttacaagatg tgcacaaaac taccaactcc gctacgaaga
    20041 gtttgactat ctagcgcctc tatacgtcgc aaaagacagt aaactcgtta gcacactgat
    20101 gcaaatctac caagaaaaga ctggcgataa cagtcctgct atttcatccg gtggtgccac
    20161 ttttgctcgc accatgccaa attgtgtagc cttcggcgcc ttattcccag gagcgaagca
    20221 gacagaacat caggcaaatg aatgtgccgt tctagaagat ttgtaccgtg ctatggatat
    20281 ttatgccgaa gccgtctatc gacttgcaac ttaatcaggc aactgtttct acaaaaaaaa
    20341 atcgaccgat taatgaactg caccccaaaa gttagacaga ataaatctaa cttttggggt
    20401 gttttattat gaaattgagt tatgaagata aagttcagat ctatgaacta agaaagcaag
    20461 gacaaagctt caaacagctt tcaaaaagat ttggtgtgga tgtttctggt ctaaagtcat
    20521 ctgaatcttt gagatgagct ttataaatcg attttttcag tttttgcact ggtgtttcga
    20581 taaactcaaa ctttttagcc gtggtattgc ctgattttat agtatattga aactagaata
    20641 gtacacctct acttctaaaa catttttaga aatcgatttg actgtcctga tcgatttatc
    20701 ctgttcttat ttcattttac tatatttgag ccacttcgtc tttaacggct ttattcataa
    20761 gctcttgtaa tttttcttta ctatcaatta cttcttattt tccgttgtaa tttattgtaa
    20821 taggttttaa cttacctaat ttctcgacac gctcattaat ttgatctttt ttgaaggctg
    20881 catatgtttt tcctaagatt ttttcgaaaa tatatttatc agatagcggt ttgccttctt
    20941 cttcagcttg gtttttgtat tgatttgaaa cataaggaac aaatccttca tagtaaccta
    21001 atactcccat aagttcaaaa gcttgttttc taattcaaac cattgcaact cagatttcag
    21061 cttttcagat aaatcctgct catccaaata atgacttgaa attagtgctg aactcgtttc
    21121 tgtatcctgt acaggctgag cacccatacc agcaaaaaat aaactcgttc ctagcaagac
    21181 cgaacaagct cctattacat atttcctcaa agaaaaacgc tgctttctct caaattgaaa
    21241 ttctttcatc ccatctccca tcattcatta ttactgtata ttttgtatat cagaaatagt
    21301 ttgtattcac aaatctttct agttattccc ttatcattcc taattaaggg agataacata
    21361 caataatttt tagttaaatg tatatcgatg ttttttgttt ttcttaataa acgcaataca
    21421 aaaagagcct gttgccaagc tctttatact caatgaaaat caaagagcaa actaggaaac
    21481 tagccacagg ttgctcaaaa caccgttttg aggtagtaga taagactgac gaagtcagct
    21541 caaaacactg ttttgaggtt gcagatagaa ctgacgaagt cagctcaaat atacggcaag
    21601 gcgacgctga cgtagtttga agagattttc gaagagtatt agtctattat ttcttctcag
    21661 cgcgaagggc tgacaagatt tgtgttcgga tatcatccac accatttggc gtatttggta
    21721 aaaagatggt ttgatttcct ttagaggcaa aggtattcaa ggtatccaaa tactggttgg
    21781 tcaagaggat agacatgatt tgttcttctg tcatgccaac attggcttcc ttgagttcgg
    21841 tgatagactc tgccaatcca tccacaatcg ccttacgttg ttgagcaatc cccacaccat
    21901 gaaggcggtc tttttctgct tctgcttcag ctgcagtgac aattttaatc ttgtcagctt
    21961 ccgccaattc ttgtgctgcg acccgcttac gttgcgccgc attgatttca ttcatagatt
    22021 gcttaacttc tgcatctggt tcgaccttgg taatcaaggt tttcacgata atgtagccgt
    22081 aagtggtcat ttcttctgct acttggtgtt gaacctcaag ggcaatctca tcttttttct
    22141 caaacaattc atccaaggtt aattttggaa cagaagagcg aagagcatct tcgatataag
    22201 atttaatctg agattctgga cgtatgagtt tatagtaagc atctgtcacg ctctgctcgt
    22261 tgacacggta ctgagtcgct acattcatca taacgaacac attgtccttg gtcttagtct
    22321 caaccacaat atcactttgc aacaagcgca actgaatccg tgctgcaatc gagtcaatcc
    22381 caaaaggcaa gcgaatatga ataccgctat tagcaacctt ttggtatttc ccaaagcgtt
    22441 caataatcgc caccgactgc tgacgaacca cataaactgt actcagtgtg actatcacca
    22501 ataggagcac acaaacaatc agaaaaatca tgaaaaatat tgccataatg gaacctccac
    22561 aagtattttt ctagtattat agcacattta aagaaggctg tgccgttttt actgcgattt
    22621 ttcctgaaat gtcaataatt agaggtgaat tgtcctattg tcgtctaatc tcttgctaaa
    22681 ataactcttt ataaaaggca atcgtttctt ctaaggttgg cataaatgga tttcctggtg
    22741 cgcaggcatc aatcaaggca ttcttagaaa ggtattcaaa gtcgaaatct ttttcttcaa
    22801 taccaagttc agtcaatttc ttaggaatac ctactgtctc agaaagcttc tcaatctcag
    22861 caatcgcata atcggcacac tcttgatctg atttaccttc cacatgaagg cccaaggctt
    22921 tggcaacatt gcggaaagct tctggtacac gtttagcatt ttcacgttct ataactggta
    22981 gcaacatggc acagcaaaca ccatgtggca aattatatac tgcaccgagt tggtgagcca
    23041 ttgagtgaac ataaccaaga ccagcattat taaagctcat accaccaagg aagatggcat
    23101 tgaccatacc ttcacgcgct tcaatatcgt atccattttc tacagcacga ggaagatatt
    23161 ccttgataag ctcaatagca ccaatagaca gtttcttggt tacatcataa gcaccaggtg
    23221 ttaccaaagc ttcaacagcg tgagtcagag catccatacc agtagcagca gtcaggcctt
    23281 taggtttgga aagcatgagt tccgggtcat taacagagat aagagcaagg ctattcttgt
    23341 caaccattac catcttaacc ttgcgttctt catcagtaat cacatagtta atagtgattt
    23401 ctgcagaagt tcctgccgtt gtattgatag ccacaactgg caagcctttt ttagcagact
    23461 tatgaagccc ttcataatcc tgtggttttc caccatttgt agccatgata gaaatacaac
    23521 tagctgcatc ctgtggagaa cccccaccaa gactgatgat aaaatcacat ccatgttctt
    23581 gcaaagcagc taccccatct gtgacattct tacaagtagg gtttggctct acatcgctaa
    23641 agatgacata ttcgattcct tctgtatcca gtggttttaa aaccttaggt aaaatgtcac
    23701 tgccttcgat gtacttatct gtcaccaaaa gtgccttttt atagccaagt tccttgatat
    23761 aaggacccac ttcatttaca acacctttac caataaggtt gactgccgga acataaaatg
    23821 tagccatata attttcctcc tgcgcctccg cgctatctat ttaacatcat tatattagtt
    23881 tttgtattcg ttttcaatta tttgtgaatt gtttaacaaa tctttttaaa aggataggag
    23941 ggacataagt tcacctccta tatacacaat ttttatttat gtagcggtcc caacaactga
    24001 catgcacgat agtctgctga ttctagatct tctgttccaa ataaggacca atttttaggt
    24061 ctaaagatat cttcctcggg tacattatgc atattgacag gaattctcaa catagaagcc
    24121 aaggtaatca agtctgctcc aatgtggcca tatgttatgg ctccgtgatt agctccccaa
    24181 ttattcatga cgtcatagac agacttgaaa gcaccttttc ctgtcaaacg tggagcaaac
    24241 caagtagttg gccatcctgg atctgtacga ttatctaaag tatggtgaac atcttcagga
    24301 agttcaagtg tataaccttc tgcaatttgt agcactggac caaccccttt tagaagattg
    24361 agacgtacca ttgttactgg catatccccc ttcgtcaaga aacgagttga gaatcctcct
    24421 ccacggaagt attcgcggtt tgctggtggg aagtctgtat tttcaagcat agcctgcact
    24481 tcactttcat ccaactccca gaagggtttc ataacaggtt tgccatctcg agtagcttgc
    24541 cctgtaccat ccaatgtaca agaaccagag ttgattagat gtaagaagcc agctgcagca
    24601 caaccctcta aagtatgtcc cgttacacgt ttaacagcct ctggactcca ataagtgcgc
    24661 acatcagcaa agatttgtgg agtatttgtt aatagataat taaagagcat agacacacca
    24721 tttagtgaat cattctctgt cgcaaataca aatggttttc gaataccatt ccagtcaaac
    24781 tgagtattga ggaaagtttc cataaagtcc ccatttggga aatggtctgt ccactgacgt
    24841 tgaccttgga aaccagctac taaagcatgg tgaccaactg cttcttcctc aaaaccaagt
    24901 tcagcaagtc ttgggttacc aaccattaag tcacgtccaa tcatgaacat cttaataaca
    24961 aattcccatt gtttttcttt ctcttcttta gaaagaatca aatcctcacg atttcggtca
    25021 actccttctt tgatatgttc ttttacccaa accatagcac gttcaaactc ttcagggtcg
    25081 taaataccac ggtccatacg gcgcgtgaac tccgtcatat ctaccgattc atttcgcatt
    25141 cctaagtatt cttggaagaa atccggattt acaatagaac cgccaatccc catcgaaaca
    25201 ctacccattg ataggtaagc agtgtctctc atcaagccag ttgcaagagc tgcacgcgca
    25261 taacgtaaaa gtttttcttt gacatcttct ggaatagctg tatcactagc ttcctggacg
    25321 tctctaccat aaatcccaaa ggctggaatc cctttttgag catgtgaagc tagtacagct
    25381 gcaagataga cagctcctgg gcgttctgtc ccattaaatc cccaaatagc atgaggaata
    25441 tctggagaca tatccatagt ttcactacca taacaccagc atggtgtaac tgtaattgtt
    25501 gcgcaaacat ttgatttttt aaacaactca tgggaagctg cagcctctgg tacacggcca
    25561 atagtagatg gagaaatcac gcattccaca ggttccccat ctggatattt caatgtgctt
    25621 gaaatcaaat ctgccacact tttagccatg ttcattgttt gcacttcaag tgattcgcgt
    25681 acaccttgac gacgaccatc aatagtcgga cgaatcccaa tacgtggatg ttgaatcata
    25741 ctattttcct cttatttttc tgtttctttc atactaccga tgataatttt taaaattact
    25801 tataagtata aacctctacc tctgccaaac ttaaaggaat tcctgcgttt ctcaaagaaa
    25861 ttctaacctt ttttcccttc agccctttta agtctatgga tagattattg ctttctaaac
    25921 tgtcaatatg ttgtttaaaa acttcatgat tatttgaatc atatataata atatcaaaat
    25981 ttgataatct ctgaatttca gcatctgttc tattataaat aattaacttt tctaattctt
    26041 cggtttgtgc taaatctatc tcccaccatg aaggagaatc tcctttggta tgagtcactg
    26101 aatgatgacc ataatctccg tttttatttc catcaactgc tagacgagaa aaaccattgt
    26161 aatccgttga actctgtcga gtttctttgg ttaatgcaat attagaaagt ttcttcggag
    26221 ttctctttga accatagact tcaacttccg ctaaacttaa cggaatagct gctgatttta
    26281 attctatttt gactagctta gcccctacag aaggtacttt taaagataac aaaccatcaa
    26341 ctactttatc aaaatgtctt ctaaaaactt cttctcctga tgaagataga aaaataacat
    26401 caaaattaga taaacgctga ggttcggcat ctgttctatt ataaatatca actttagaaa
    26461 ccgtaaactc ttctcccaga tcgacctgcc accaagcgtt agaatctgcc ttagtatgag
    26521 tcaccgaatg atgtccgtaa tctccatctt tattaccatc aactgctaaa gcagctacac
    26581 cctcataatt ggttgaactt tgagtagcta ccttatttgt agagactact ttatcttctg
    26641 ttattttatc tatatcctct tcagattgct taccatctga ttctctaaaa acctctactt
    26701 ctgctaaact caaaggcact ccactcgtta gtaatttaac tttaatatac cttgctcctt
    26761 tttctttgaa atctagacta acagattcac ccgacaaatt attaacatgt ttcttagcaa
    26821 cttcgtttct attattgtca tatagaatca catcaaaatt agatagacgt tgagtctcag
    26881 catctgtgcg attataaatt ttaacaagcc caactttatc catttttttc aaatcgactt
    26941 cccaccaaga gggattatct gccctagtgt gtgttaccga accagagtta aaattaccat
    27001 ttctgttacc atccacagct ctattagggt ctccattgta atctacagaa ctttgtgttg
    27061 ttggttttgc atatgctata ttcaaattac catcattaaa tttatctggt gttgggaaag
    27121 ggactgggcc tgtcccttca gtatttatag acatctctac cattccatta tgattaaccg
    27181 taatggtata aacatgggta ttctcatccc aattttctgt ataagtataa tgatttttat
    27241 cgccacttat atttatctga ggtttatgac cagtatgccc ttttaatgta agtgttgttg
    27301 tcctaaagtc attatctaca ggattgatgg aataattttt gcttatccag ttcgctaact
    27361 ctaattcttc tttcttccaa ctttttgatg catcaaaatt tcctgataat gcccacatag
    27421 ctgtcttatc tgtcctgtaa ttgttcaata aaatatgtaa attatttgga ttttctttaa
    27481 caacagcgta agtatgtggc gtcaaatcta acgataacga ctttgtatta ttagtataca
    27541 taggcaacat tacttgctga tttttattga tattagcatt actattataa atataccagg
    27601 aattacctac acgctgagca tacccatctc cttcataaag ttttggataa agcgagttta
    27661 aatagttgac tttactagac aattcctcac tatttttagt caaaattttt gcattaggga
    27721 atatagatga aatcttttcc ttatcaattt tctcatgtat tacaggaaga atatgatatc
    27781 tcccattatt atataaaggc attgtttcat cattcgaata aagtccttga taaaatccgt
    27841 ttaatgaact aatcctacct tctccattcc aaaatacagc ttttgttcta tttacaactt
    27901 cttccttact tggagctgga ttttgtatag catgtctaaa gaaaggaata atacctttag
    27961 taaatgctgg agttggtaca tcatttgtca taaatgtata cgcggcacat tcgaaattat
    28021 aaactgtgcc tcccccagta tatacattca tcatttccat agcaatcatt gattctggtt
    28081 ccgatgcata ggatctcata tccctagctc ttccagtttc aaatgtgttt gtataatgtt
    28141 tttcccacca tttccatgta tctgttgatg agccccagtt atcacataag ccactcaacc
    28201 aaaatccact aacgatagaa tctgtacccg catcatctct tattggcgta tttttagttg
    28261 ccaacaccaa atttttatga tatttttgac tcgcttcaaa gaatgtcgga tcattcataa
    28321 tagtttccca gaaccatttt tcatgatcat gccagataaa atgcgctcca tatttggcac
    28381 aaacttccaa atatttagca ctatgcggag ctaactggtt attgtaaatc caataattct
    28441 caatatttaa aacacctttt aacacactat acttttggaa ttgttcatct aaccactctg
    28501 gaggaactgt attacgctct ccagccgaca taataaccaa gaaaactgga atgtttagac
    28561 tttgagcttc ctccaacatc ttgacatacc attctctcaa ttctttcgta tctcgtggaa
    28621 tacaacttgt tggtttacag acttttgcag gatgaagttc aatcgctgca tatggtttta
    28681 catcttcagg aatagcttcc catgctccct tcaatgtgtt cccccaccat aatccgttac
    28741 cattatcatt gccatacaac ggagaaagca acaatggcga ttcattatta atcgtcgttc
    28801 tcatttgaac acgattatca gccttaactc ctgctaacaa tccaaaacat aacatcccaa
    28861 tacatacaaa cagtattgtg attaattttc tttttatttt ttctttattc atgacttata
    28921 cctaaaaatt taactcaata attttttctg aattaaatac caattcaata ttttgtacat
    28981 cagtattttt gccatatatt cttactctta ctttttgatc tttgtttcct ccttccaatt
    29041 ttaggaatgt tatatccccg tttttccaag caaacgatac cttatatcct cctcttactc
    29101 tgaaaccttt cacttctcct tctgaccaag cagaaggtaa agctggaatt agtgataacc
    29161 aattatgatg gctctgtact aataattcac aaattccact caccaaacct aaattaccat
    29221 caatttgaaa tggtggatgg tcaagaaata aattgccaag agtcgcatta tttaacaaac
    29281 cattaatctg gttataagca ggttcacctt gatatagtct cgcaaaaaaa tgaatcagcc
    29341 atgcagcact ccaacctgtt tgtgtactag catgcaaacc acttactaac caattattaa
    29401 tcgcttgctc cctctcctgt gaagataaaa agttagcgtt tgataatctc ctattgatag
    29461 tgattttagc tgcttctgct aattccggag ttttatgaat atcaatctca ttataaggat
    29521 aaagcccaaa tagaggtgaa atgtgtctat gcccaggctc tacttcttca taatcttcta
    29581 accattcttg gatttgccca ttactaccta tttttgtttt aggtagtttc ttttttaact
    29641 ccttcacacg actaataaaa tccgaattgt ctcctaattg ttttgcaatg ccaatgcatg
    29701 aatcacaaaa atatcttaga atttgattat caattgtaga tgatagacaa gcatttcctt
    29761 caataccatt ttttaagcga tatttatttt ctggtgagac acttggacct gtcatcaagt
    29821 agccatccac ctcaaataaa taatcttcaa agaaaagaaa tgcttctttt atcatttcaa
    29881 aatgttccgt aagaatacgc tcatcttgga aatataaata gtgttcccaa atatgagtac
    29941 ataaccatgg aatagttaat acccaaattg cagcccccat ggcatgagat tggggagccg
    30001 tatcgccaaa accatccgta ttatgatgtg ctgtaaaacc tctagctcca tacattttct
    30061 tagcggttag tcttcccggt tctctcattc tttcgagcat atcaaataat ggatattcta
    30121 cttctggtaa atcacatgga cctaccatcc aataattcat ttgagtatta atattaatcg
    30181 tatatttaga accccaaatt ggatttaatt catcacacca tattccttga agattggcag
    30241 gtaaaccatt cggttgacta gacgatatta acagatatct tccataatga aataacaagt
    30301 tagtcaagta gttactatac tttttagtgt tttcaagaag tagattcgtt ggaatgctaa
    30361 gacaatcttt actatagtct agtttaaaat caactctatt aaattgctcc tgatattttt
    30421 ttacatgttc atctttttct gtaaagtaat caatactact aaattctccc tgaagagaag
    30481 aaatatctat atttccccaa taattcgtca ttgatttgag ataaagaaat acctctgtag
    30541 cattccgaat aactattgtc tctcccaata cacttacttc accatccgta actttagaat
    30601 gacatactac tttaaactga acaccttttc tacctccagc agaggccgac attaaaattg
    30661 tacttgaatc cagtttagat acttcgtcat taaaccgttt atttctaccc aaattaatgt
    30721 ttaaatttaa tgtgttttga actgatgaca ctatacggca acataaaata ttcttattaa
    30781 aactcgtaaa atattctctt tttatttgta aattacaact attaggatca aacacaacat
    30841 tagaaatagc tgtatctaaa tctagctctc tttcatacaa tgaaagagca caagactgaa
    30901 tatctatatg ctcaatgtaa agttccccaa gtaattcata gtggctttga tctcttgggg
    30961 tagcaaacat tgttaacttt atcaattctt cggctttctg aatttctcca tctaaaagat
    31021 attcccgaat ttttttaaga tgcaatagtg agtctggatt atttctatct gactttcctc
    31081 tataccaaat agtctcatcg tttagttgaa tacattcttt tgtagctgaa ccataaatca
    31141 taccacctaa atgaccgttc ccaatcggca aggcttcatt ccaatttgag gcagctttct
    31201 tataccataa tttcactctt tacctctctt ccaaaatgga ggtgatatcc caaataccac
    31261 ctccacactt tctactactt caaaattcct aaaacaacta ggataactcc aatagccata
    31321 acactaaaga ttagtacaac cggattcttt ccttttctaa ttaatttaca cattaataaa
    31381 gtcaaagcca tagggataaa tcctggaatt aattttgtaa tcatttcttg aacagaaata
    31441 acaagttccc cctgtttaaa ttctaatcca aaattaatac caaccattga tggaatcaaa
    31501 ccacccacta gtactagccc taatgctgtc gccatactcg taacgcgatt caatgttcct
    31561 tttgtattat tttcttggat aagactagaa cccttagtat acccatattt caaaccgaaa
    31621 tatttaacag gaatattaat aatattaaac aatattaagg cgataaagat acctaaagca
    31681 ccgccgtctt tagaataaga cgcaccaata ctaaaacaga taggaactag tgtcagccag
    31741 aacaaactat ctcctagacc agccagcggc cccatcaagc caactttaat accagtaatt
    31801 gaagctgcac cttcatttcc ttcttgttct tccatagcgg aagtaactcc aagaataaat
    31861 ggtgccgctg tttgatgagt attgaaaaac tcaaggtgac gtttcattgc aggagaagct
    31921 gaatctttgt ctgggtatag ttttttcaat actggaagaa ttgtatatag aaaacctagg
    31981 ttctgcattc tctcatagtt ccatgaagaa ccatacataa aacttcgttt gaaaactttt
    32041 ttaagttcaa ctttagttac tttattattc atcatagatc aagatcctcc tcaacatcac
    32101 tacttgaagt tgtttcttgt ggtttacttc caatcatatc gtagaagtat gctaccgcaa
    32161 taccaactag tgagatccca atggttgaca ttcctccata cacagaacaa atgaatccaa
    32221 tcaacaagaa tacccacata tttttcttga gcatcatatt taaaagcata ccaaaaccaa
    32281 ttgaaggtag taaagcacct gcagagttaa gtccctgcat aacgattggt ggaaccttag
    32341 caaacaagtc tgccacatat tcccctccaa gcataatagc taggaaaatt ggtacaattt
    32401 taaataaagt gattaaaacc aaacttgaat aatgataaaa accgatcttt gaataatctc
    32461 cgtttttagc atcattatca gcttttttca caaaataaac atctaaagtt tttgcaagaa
    32521 catccaactg ttgggtagca actgcaattg gaactgctat agcgatacca gcagtttctc
    32581 cttgaccaga caaaatacca aatgcagtac caataatcgc acctgaaata gtatctggtg
    32641 gagtgtaacc tccaatacct gttacaccga gccaagttaa ttcaagagct gaaccaataa
    32701 gaacaccttg ggtgaaatct cctaagacta agccaaccat tgcacttgta actaacggac
    32761 ggtgaatcat aaataacggt ccattatagt caatagtggc aataatccca actaatgtca
    32821 ccagtaatgc ttgtgtgaat agcatatact gtacctcctt aaattatttt tataaaaatt
    32881 tttccaacat tgtaacttta tcattaggaa ccatttgaat ttcaactctc gttcccttat
    32941 caactatttt cttaaaataa tatttgtctt cttcacctag agctacacct cccgttacct
    33001 tttcattttc ctccgtttta ctcatctgtc ctacattgag gtactccaat tttaaatttc
    33061 cttcaataga atcatacaca tcttttggat ttgtatatat cagcattgtt ctctttttta
    33121 ttggcacaga gtttaaaact tccacaaacc gttttacact aaagaaaaca atttttaaac
    33181 ctaccggtgc agaaatcttt aaaatagatt gtcgtgtttt atcttctgag atgcgatcat
    33241 taacaatgat aacttgctca atatcatact tttttagcca cgtagtgaca acttgaccat
    33301 gtaccagacg gtcatcaata cgaacaaact ctatagacat aaatcctctt cctcctctac
    33361 gttaagttgt tgtttaacat taaacaaact attttgagca ttttgaacaa tttcttctaa
    33421 attgattttt gaatcataac ttgatattaa ttccactagg agagggatat taaaccctgt
    33481 tacaatatca actgaatcca aatttaaaaa ccgtgacaaa gccacattat taggacttcc
    33541 tccaatcaag tcagtcaaaa cgataacctc ttgatttgag tctaacagtt catttacttg
    33601 atttttaaaa taatgttcaa actctacaat attctctcca ggcatcaaac ctaatgtcct
    33661 aactctatca tttgttgtct caccaacaaa catttctgcg gtcatgagag ctccgctagc
    33721 aaaattacca tgactggcaa ctaaaattcc tctattaaac attttctctt tcaacaacta
    33781 ctcctttctt aaggataata ttagcataaa gtgaagtttc tcctgtagca acaatagcat
    33841 aagctttctt actacgttca taaaagtctt ctcttctaag ataagtaatc gttttaagat
    33901 ctgtaccatg accttcaatc atctgtctat aggtacccca tatcttagga atatcatcac
    33961 ccgaaacaac gttcataaac tgaattgaac tatcgacgta actatctaat ggcattaaat
    34021 acagaatgga atctaataat tctggaatat ttacaccatc acaacgaatt agcttatttg
    34081 cacatgaggc agaaggataa ttcgcgtcag ctaatactat ttcatctcca tgtcccattt
    34141 ccattaaagt cttcaataaa tctggagaaa tatttttcgg tatatgtttt aacattaata
    34201 tcctccctat tttctctgac cgtatgtttt aaatttttct gccattaaat ccatctcctc
    34261 atcaggaaga actactggct ctccaaaatt cttagctaaa caataaattt ttgcacaata
    34321 ttcaacttct tcaacaatat taaatgcatt caataaattt tgtgcacctg ctaaaattcc
    34381 atgattcgct agtaaaactg ctctacgacc ttccattgct ttagctgcat tcacagccaa
    34441 ttctttcgta ccatatgttg catactcagc tacccgaaca tctttccctg ccactgcaat
    34501 catataatga ctagccggaa gtggttctct gagacaagct aatactgttg cataagttgt
    34561 atgagcatgg ataattgcat cgatatcatc acgagtttgg tattgaatca aatgcatata
    34621 ccattcgcta gatggcaagc gttctccctc tacaacattt ccattaatat ccatcactac
    34681 aatatcggat tctttgattt caaagaaatc aatacccgac ggggtaattg ccatcaattg
    34741 tttttcacga tcgaaaacac tgagattccc acctgttcct ttcgtcaaat ctgtttctac
    34801 tagcttcttg ccatacttaa ttaattcttg ttttacatct gacattcttg tcctcctcat
    34861 atcaaaacac taaatatttt tcaattcacc aattatcccc ccttcttgta caaaacttaa
    34921 gaagggggag ggaggcaaat ttacaaactc tcaatctttt taattctttt gggagtaata
    34981 actctctaat tgtaggaact cctcaataac atggtgagct tcttccatcc cttttaattg
    35041 tcccatagct atgagctgca caacaatatt ccccacagct gtaccctcag tcgaacctgt
    35101 aagaacctct ttaccagttc tatcagcaat catttggtta aagtaactgg ctctagcacc
    35161 tcctccaatc acatatatcc tcttataaac cttatgagtt agttcttcta gtaactctat
    35221 cgctttccta tacgtttcag ctaggctttc ataaacaatc ttaaatagtt gtccatctgt
    35281 ccactctcta gtttcatgat gataagctag atattctgtc aaagtcttgt gcatatcaga
    35341 ttctgttgca aattcagttg attcagtatc aatcagagga agattttctt tttctttctc
    35401 caccattgtc ctaatatcat caaaagaata ggctttccct cttcgttcaa atgaacgtct
    35461 tagttcctct atgatccaca accctgtaca attcttcaga aatgtaatca ctccatcttt
    35521 accgacttca tttgtaaatc cataactgaa ggattcggta gtaagaatcg gtgaagtaag
    35581 ttccactcca accaaagacc aagtacctga tgaaataaat aaactacctt ctgtcttagg
    35641 tactgagaca atcgcacttg ctgtatcatg actacaaaca ttcacaacag gaatatcgcc
    35701 taaaccatac tcctttttta tccttccaag aacatttccc tctgaaacaa tttcaggaag
    35761 taaagatgaa tccaattcaa atagttttaa gatattctga ttccaatttt gactcctagg
    35821 atcaaataat tgagttgttg aagcaatgct tttttctgta gcaaacttac ctgtcaagag
    35881 ataattaaac aaatctggca ttaaaagaat cttattggtc ttatagaaag agtcaggaga
    35941 ttcttgacgt gccttaaaga gttgaaacaa ggtatttatc tccataatct gatttcctgt
    36001 ctctgaatac agtttttcta attcagtcat ttcagatatt tcctttaaca ctccctttgt
    36061 tctttcatca cgataatgaa caggttgtaa taacagctta ccttcattat caatcagtcc
    36121 aaaatcaact ccccatgtgt caataccgat agataaaatc ttgtaactag tattagccaa
    36181 gcggatactt tcaagaattt tagctagtag aaagtcaata tcccaagata aatgcccttt
    36241 tactctaata ggtagattag aaaagcgatt tatttcttcc attaccagtt tattttcaga
    36301 aaggtaacca acgattgctc ttccagaagt cgcacctaaa tctattgcta aaaccgcttc
    36361 catttttctt ctctcttcgt ccttgattaa gtttattata atccccacgt tttatttttt
    36421 caatatgtga acgcttactt gaataatgtt caaatgttaa cccaatattc ataaaaataa
    36481 ttcaaattcc tccaatttgt gctataatat agttgaaatg ataaattagg aggagcttat
    36541 gataaaagat gaacgtgtac ttgaattgat tgaaattatc aaaaagaaaa aaagaattgc
    36601 cgtaaaagag ctggcagaaa tcactttctc cagcacaagt accttacgtc gtgatttaat
    36661 tttcttagaa aatcaaggtc ttatcaaaag aaagcacgga tacgtgaccc tgtcctctat
    36721 gaacacaatt gaactttctc atcaaatacg tgaaggagaa agtactaggc aaaaaagact
    36781 aatcgctagt ctcgctaaag actttattcg gtctggtatg tgtatctatc tagattctag
    36841 tactactgtc tacgaacttt gtccctatct ttctgaactt gataatttga ttatttttac
    36901 aaatggttta catactgcac aaaccctatc tgaaactgtt aaagatagct ccaaaatctt
    36961 tatcacatct ggcgaggtca aacatcaatc ctgttccgtg gtcaactatg ataaggaaaa
    37021 ttctttatta gatcatttta atatcgattt agcattttgt tcagcaagag gtattgatga
    37081 ccaatatgtt tatgaagctt ctctcagcca agctatttca aaaaagaata ttattgacaa
    37141 agcccatgaa accatcttac tgattgatag ttctaaattt tacaagactg gattttttaa
    37201 aattaatccc ctatccaaat acacaacctt tatttctgac accttgccag accaaaaatt
    37261 attagacgca gtcgaattat ttgatggaga atgggtttct gatattcaat gaaaatcaaa
    37321 taggaagcta gtctcagctt gctcaaagta cagatttgaa aattgatgaa gtcagctcga
    37381 aacactgttt tgaggttgta gatagaactg atgaagtcag tcacatatat acggaaagac
    37441 gaagctgaca tgatgtgaaa agattttcga agagtattcg ttctgtctgc tgactgattt
    37501 acaaatattc accacatgac attattttct tagcaaccct aaaaacagag actggacaaa
    37561 aactcaattt caggagaaaa tggagtaaac cttcccacaa taaaacgcat agtatcaagt
    37621 ttttgcacac ctgatattat gcgtttttct gattttaaag actttgtcgc ctagacccta
    37681 tatttcaaga attaagcgac cttgatgatc taaatgtatt gtggtatact atttttgtca
    37741 tcggttaccg attacgttcc tatgggttcg tgagaggagg tgaaactaat gagccttatc
    37801 atagagcttg ctcttactat tatagcggat gttatagctg gaattatctt gtatttcgtc
    37861 tgcagatggc tagatagtaa ggagtagacc gactgactag cctataaaca cccgttaaat
    37921 cgctaagata cgtcaaaaaa gcccttaact acggccatag ttaggggctt tggtgttcta
    37981 atgaacctta tcaattaact acattttagc atataatcta caatagttca agcattaagt
    38041 gaggttgatg atctaaattt agtgtggtat aatacttttg tcatcggtta ccgattacgt
    38101 tcctatgggt tcgtgagagg aggtgaaact aatgagcctt ataccagagc ttgctcttac
    38161 tattatagca gatgttatag ctggaattat cttgtatttc gtctgcaaat ggctagatgg
    38221 taagaagtag accgactgac tagcctataa acacccgtta aatcgctaag atacgtcaaa
    38281 aaagccctta actatggcac tagttagggg ctttggtgtt ctaatgaacc ttatacacta
    38341 actacattct agcatataag cccagatatt tcaagagttt tatttatttt ttcaggttcc
    38401 cttagttctg aaaggtctat aatgaagtta gccatctagt atcaaaaaac cgactagctc
    38461 ttatgaacta gtcgatttct catcaatgcg ccaacatttc ttgggcgatt tcttggccag
    38521 ataggttatc tgggtagtag gttggccagt tgtccatttc ttcaaagagg gcttcttggc
    38581 ttgtgcctcc aaagaagata tggaaatgtt ctgccttaac tggggcgata ttgtggtcac
    38641 taaactgaac atacttgaat tgtccagcgt cagcatctgt ggcttcaaat aggaaacgca
    38701 cgccacgatt gcctttcttg taagtcaaaa ttttcttacc gacatacttg taagtgtatt
    38761 tcttgctttg tccaccttga acaaattcca tagtattatc agtaatgtta atcttagtca
    38821 catctgtctg atagcctttt gtatagtaag ccttgtactc agcctgggtc atcttaccag
    38881 tcaacttagc cttgtagtca aagacttggt caaacgtgcc gtcttcaagg aaaggataaa
    38941 ctgattgcca gttacctgca tagtcactca aggtgcggtc cttgacagct gcatcctcga
    39001 agtaaccatt ttggactgtc ttggtatcct ctgccttttc aggttcgatt gctgggcctt
    39061 cttggtctgt tgtttgtttc aaagccttga ggtttttctc catcacggaa atgtagtttt
    39121 ctccagcctt ggtgtcctct tctgtcagac tttctaaagg attgaggaca tcagttttga
    39181 cacctgcttc ttttgaaagt gtgttagcaa gggcttgtga ggcattttct tcaaaataga
    39241 tataggcgat tttatttttc ttgacatact ctgtcaattc tgccaagcga gcagctgatg
    39301 gctctgcatc tggagaaagg cctgagattg cgacttgttt gagtccatag tccaaggcaa
    39361 gatagttaaa ggctgcgtgt tgagtcacaa agctcttttg ttttgcttga gacaagcctt
    39421 ctgtgtaagc cttatccaag gcttgcaatt tttcgatata ggcagctgca ttcttctcaa
    39481 aggtctcttt tttatcagga taatctgctg acaagctgtc gcggatgtgc tctactagtt
    39541 taatggcacg aactggtgat aaccaaacat gggggtcaaa ctcatggtga tgaccttctt
    39601 ctccatggtc atggtctccc tcttcttcct cgccacctgg caagagcaac atatcgcctg
    39661 tcgccttgat ggttttcact tttttcttat ccaaggtatc tagcaattta ggtacccatg
    39721 tttccatgtt ttcattttca taaacgaagg tatctgcatc ttggattttg gcaactgcct
    39781 tggcagatgg ttcgtattca tgaggttctg tcccagcacc gattaggagt tctacattag
    39841 ccgtatctcc tgcgacttgc ttggtaaatt catagacagg gtaaaaggtt gtcacgatat
    39901 tgagtttacc atctgcctgt ttttgattgg aacaagccac taaaaacaag gcacatagac
    39961 tggctagtaa taagctaatt tttttcacgt tcgtctccta tttgataaaa cgtcttacta
    40021 aactgattag tataaagaca gttacaaaaa taatggtaat acttgcactt gcaggtgttt
    40081 ctgcatagta ggaaatgtaa agtcctgcta ccattcccaa aaagccaatc gcactggcaa
    40141 gcagcataac cgatttaaag tttttcccca gacgcagggc aatactagct ggcaagacca
    40201 taatggtcga taccagaaga gctcctgctg caggaatcat aagggcaata gccacccctg
    40261 tcaccatgtt aaaaagaatg gacatggtac gaactggcaa gccatccaca aaggccgtat
    40321 cttcgtcaaa agttaagata tacataggac gaagaaagag aaaggtcaaa atcaaaacaa
    40381 ccgccgcaat gacaaagagg gaaatgacct gttcttcact gatagtcacg atcgaaccaa
    40441 agagatattg gtccaaactc attgaactcg agcttttacc cttgctcatg acaatcagag
    40501 aaacagccag acctgttgac atgaggatag ctgtcccgat ttccataaag ctcttgtaaa
    40561 ccgtacggag atactccaga aagaccgccg caatcaagac aatggcaata gtagaaacag
    40621 ttggagaaat ccccaaaacc agaccaaagg ctacacctga aagtgagacg tggctaaggg
    40681 tatcactcat caaactctga cgacgcaaga tgaggaaggt ccccaatacc ggtgagaaaa
    40741 gactcatagc aataaccgcc aaaaaggcgc gttgtataaa gtcgtaagat aataaactaa
    40801 gcatggccca cctcctggcc attctcatga acattgaaac aacgccatgg cgagtcttgg
    40861 ttacggacta gatgaatatt gcgatccgca taatccttaa cttcttcagg gtcatgggta
    40921 atcatcaaaa cagccttgcc atgatgatgg gcactgtgat gcatgagttc gtaaaattca
    40981 tttttacttc ctgcatccat ccccgttgtc ggctcgtcta ggataaacac atcagggtca
    41041 gaagcaaaca tacgcgcaat caccgctcgc tgcttttgtc ccccagatag agaacccaag
    41101 cgtttgtctc gatgttccca catgccaact gagtccagac tggccttgat atgctcctca
    41161 tcatgagcat tcaaacgacg gaaccagcct tttctcggat aacgacccga cttgacaaat
    41221 tcatagaccg tacttggaaa accagcatta aaactggcaa tttgttgagg aagataggct
    41281 attctcaatt tcttaccttg cgtatttgtc tttgaaatag ccacctttcc aatgcgtggt
    41341 tgcagaattc caagactggc cttgatgagc gtcgtcttag ccgctccatt ttccccagtc
    41401 aaggtaacaa attccccact atcaacacta taattgatat gttcaagaac aggctcctta
    41461 tcataataga aggacaaatc ctctaccgta atatatctca ttatttgatt tctcctacta
    41521 aagcagtcaa aaaccgctga atcacttttt gttcatttgg agtaaactga gtcgccactt
    41581 gttcataggt taaaagtgta tgctcatggt gatggtggtg ctcctcagcg attggacgag
    41641 ccaagtcagt caactgataa aaaatcacac gcgcatcttt agaatcttta gatgtttcca
    41701 acatcccttc cttgaccaaa gacttaatgg ccttggtaac tgccgcctga ctgacattga
    41761 gacgacgggc caattctgaa tttgttaaag attcctctga caagagcata aggatatgct
    41821 cctgagtatt ggtcagggcc acctcgctag tgcaatgacc tattaggatt tcatgctgat
    41881 tttccgcctg caaaatcacc tcattcaaaa aagcattgat atcctttgct agctgtctca
    41941 tatctgactc ctttcctttt agacttctct tttttaagag aaaaatacta ttctttgaca
    42001 ttttgtttac cagttaatta tatcacaagc aaaaaaagag tcaagaaaaa acgtgaaaac
    42061 tagtttcatt cttgaactct tctatattat attatctatt gaaattcttt gacatctcca
    42121 tcataagtcg cccaatcttt gctgaaaaag cgctcattca gatggtaagt cggagctggt
    42181 gtgggattgg ataggaaagg atcaactgcc ttgtcaaaag ccaaccaacc caaccaacca
    42241 aggtgaatgg tgtccttcat aaagaaaggc tccccgccgt ccttagaaaa atctgctata
    42301 ttggtaaaac cttgactttc taactggtag cgaatcttct gcaccgtttg ttggtacata
    42361 tcctctcgta gaccagcata gtccatccat tttttattaa caggtggaat gataaaaatc
    42421 gggtttacct tagatttaga aaactgtgtt aaaaccaact gcaagtcatt atactctggc
    42481 gacttgagat aggtaaagct tttctgagaa tcctttaatt tcttcaaatc cttcttgatc
    42541 tgctcattat agaaataatt ttccattccc atctcattat tggaagtatt tttttcagca
    42601 tctgctttga caacatcttc tattgcttga taagaaaact ggtctggcaa gatttttaaa
    42661 tacttagcta catgcttatc gtagttaaca tagcctctaa ccgaaaactg accaaaaaag
    42721 gaggcttggc gttcattaaa acgagccaat aattcaatca tttcattgtc tgctgtcgac
    42781 aattctcctt tacttgccaa cttttgaacc aggtccttca tagctacgtt tgggaactgt
    42841 tgcagtaagc gagtcgctgc atattgacta gcctgatccc cagattgatg tttcagaaaa
    42901 ctagtcaact ggtctccatt aaaatactgc tggaaggctg ctggatcata gccattttta
    42961 ctgaaccact gaggtgagat aacatacaca acttgtttat tctccagctg tggtaacatc
    43021 tgttgcattc caaaatattg gttaagcgat gcagctcccc cctgtcctaa aagataagga
    43081 cggtaggaac gattgtattt ctcagctaat accgcaggat gagcaccatc aaaacgaagc
    43141 cattcactag agccaaagaa gggaacaaaa cgcacatttg gatcagatag tgctctgact
    43201 ttttgacttc gctccttaaa actatcgata gtagtagcca ctgctgaacg cttttcagct
    43261 cctagattat gatgcatctc agtaggataa aagaaaatga gcagaaaaac caacaaacca
    43321 gcgatcaaga ccggtccgaa gatcatccat aagcgtttaa gcattttgta gctccacaat
    43381 accagctatg attttattag ctgtattcca gtcgtcacga ccaaactctg ttacagggac
    43441 acgaatgtca aaacggttct caatctccac aatcaactca accgttccca tactatccaa
    43501 gacacctgca tcaaaaagat cttcatccat catgtcagaa acatcttcca taaacaactc
    43561 atcaataatt tcaataactt ctgatttgat atccatattt tatttccttt tattttttaa
    43621 accatagatt attcaagaat ccagaaaaga ttaagaatga caacatgaca acatggaaag
    43681 tgacaaccat gccaagcaac tgaatccagc gattctcagg tagggcagcc ttccctgctt
    43741 ttttccgttc cttattgagc gtttttttct tgcgaaccca ggcatcattg atgaccaagc
    43801 ctagtccatg aaagagtcca taggcgatat agtaccaggt cacaccatgc caaaatccca
    43861 taatcagcat atttacaatg taggccatgc ttgaggttac attacgattt ttaaagactt
    43921 tctttctggt taacaccatc accattcgca taaagacaaa gtcacggaac cagaaggaca
    43981 gactcatatg ccagcgattc caaaactcct ttaaatccct tgataaaaag ggcttgttaa
    44041 agttgatagg gctacggatt cccatcaagt ttgagatggc caaagcaaac atagaataac
    44101 ctgcaaagtc aaagaagagc tccagaccaa aagtatacat aactgccaag gcatagagat
    44161 taaagaagcc acctgactgc aaggctaaat tcttcagagg aggtagtaag gtctctccta
    44221 aaacatgagc taggataaac ttatacaaaa agccccacat gatatagcgg acagattcat
    44281 ccagcatatc catcaactca tctcgctcag gaatagcctg ataattttca ttaaatcgct
    44341 taaagcgatc gattggacca ctcgagaaag ttggcatgaa gagaaggaaa cggaggaatt
    44401 cccagagggt aaaatcctta atcactccat ctctcagctc gatgataatc ccaaccgaac
    44461 gaaaggtcag gtaagaaatt cccaagaacc caagcaaaga ctgcgttcca ttgatagctg
    44521 gttgcacctt gacaaagata atcggaagta gggacagaaa actaactaag tagaagaccc
    44581 acttgccatc cttgcttttt cgataatgct tgtagaaaag caggagcaat atttcccagc
    44641 aaaggtaaat acccaaggca gctagttgat tggtctttcc acccaccaac atggtgacaa
    44701 taaagaagag acttaccaac acttcatacc aggcaaagcg tttcttgaaa aagagaccta
    44761 taaagatggg caaggttgca gcaatcacat aaacaaaata ctgaggattg ccatatggct
    44821 ctaaatgagg aagctgttga aaaaactcca tcatctctta ttcacctcgt taatcaatcc
    44881 tttgatgtca atctttccat ttggagttag tggcaaactg tctcggtaaa ggaatttaga
    44941 tggcatcata taggacatca tgatgtctgt caggtcttcc ttgatggcct tggtaatatc
    45001 gatatctcgc tcaaactgct cacgaacacc gtcttttaag atgacataag ccaatagatt
    45061 ttgtaccttg tggtccttgt tatagcgcgg tactgcgaca gcagattcga taaagcgaga
    45121 cttgttgagg ttttgagaga catcttctaa ctcaatgcgg taaccgttaa acttaatctg
    45181 gaagtccatg cgtccgccgt agagaagcaa gccctcatct gtcatggttc ccacatcgcc
    45241 tgtgtgatag gctggcagac cttcaaactc aaagaaggct tctgctgttt tttcaggatt
    45301 tttcatataa ccttttgaaa cagctggccc agaaacaatg atttctccct gttcgccatt
    45361 tggcagttta tttccttcct cgtcaatgat aaaggttgga gaatcagcct tggtatagcc
    45421 gattggtagg cgtttgagag tcgctaacat ctcgtctgtc acggcaactg ctgacagagc
    45481 tactgtcgct tctgttgggc cgtaagcatt gatgatacgg gcatttggga aacgctcgcg
    45541 cagtttttga gctgttttga ccgtcaattc ttcaccatca aagtagaaat gcgtgattcc
    45601 aggcattttc tcactgttga agtattcaga caacatggcc atatctgcaa aggatggtgt
    45661 tgatgtccag atagcgattg gcaatgaaaa gatagccgca aagagttgct taaagtcctg
    45721 agtgatgact gaaggaagag tgaaaagcgt accaccaagt gccaaggtcg gtgcccaata
    45781 catgacagac aagtcaaaag aataaggtgg ctgtgccagc atttgcggac gactcggtgt
    45841 cgcaaattcc ttatccgtaa tcatccagtt tgtaaagctg aggagattat catgtgaaat
    45901 ctgcactccc ttaggcttac cagtcgtacc agaagtaaag ataatgtagt aattatcatc
    45961 tcccttgact ggatgcgtga tttcatagtt gttcccttgg gcaaaggctt cttgaacctg
    46021 agctagattt atcattggtg tagaaacctg ctccaaggga aaggctgaaa tggcaataat
    46081 caagcttggc tctgctactt ctaaaatagc tgaaactcgc tccaaggccg aatggctatc
    46141 aattggaatg taggcatgac ctgacttagt cagcgctaca aaggttgcca acatttcata
    46201 ttcttggcca ccaaaaacaa ccacaggaga cttctcaggc aagcctagtt ggtcaatgac
    46261 tgcagccaaa ctatccgaat cagcctttaa atcgccataa gtgtgttcct gccccaaaac
    46321 attatagaca ggatagctag gctgtgtctg agcaaaatgc tcaatggttt caatcatatc
    46381 tgctattggt ttatttgaca caatagggat tctccttcaa gttaaaattc attatagata
    46441 aagcttcctt gaccctgacc aagatagcta aagaagtaaa gcagccctag aaagataaga
    46501 aaatacaagg ctgtccgacc aagaaagagg tacaattctt ttctctgttt catcaagaaa
    46561 aaccattcat ttctgtaatt tttcgctaaa ataagagtga ttcttactag cttatttttc
    46621 taccattgta ccactttata tagtatcttt tcaattgttt accgtatgtt tccaatagat
    46681 ttcagcttat tttaaggatt atacagtttt tctatgtata ttttcaaata gagtgatcct
    46741 gcttcaaaac tccatttcag gagacaatga agtaaatctt cccataataa aacacacaat
    46801 atcaagtttt ttcaacacct gatactatgc gcttttctga tttttaaaga ctttttaacc
    46861 actctctcat ttaaaataat ctcgtctgat ataaattaaa atagcttcta tcatcagaca
    46921 aatggctgat agccaaaaac tgatgctaat accaaaactc tcagtaatat agctcattag
    46981 caaaacaaat actgaaaatg ctaatgtaga aatcacttca agaacggaat agacattaac
    47041 taaatgattt tcctctactg tttcctgaag aaatacactt tcaggaactt cttttagttg
    47101 cgataacata ccaactaaag ctgaaaataa taaaaacatc tgtgcgtttg gaaaatatag
    47161 aatagtcagt gtcactattg ccatagctac aagaggaaaa agaatacttt cccatttagc
    47221 agcaaggaac ttttcagata gcctaaaagc aattaagcca ctaattataa taccaataga
    47281 gtatgctgta ttagaatatc cccagtaact ttccgtttta tttaataact ccgttacaaa
    47341 aacaagtata atggaagaaa cccaaatcgt atttgaaaaa atttccaata aatttgctga
    47401 tacaaaaagt cttaatctag gatttctagc aactaacttc caacctttga gcaaaatttc
    47461 aagattagtt tctgactcta acacctccac ttcagcgtta ggaagaaata acatcagaaa
    47521 gctagaaatg atatacaaga ctaaattgat acacgtggta ggtaacagac caattgttgc
    47581 aaacaagagt ccacctaatc cccaacctat caattgaaca gcttcaccag tcattgataa
    47641 ggctgaatta gccttaccca aatcggtcgc atagcgtggc acaatagcat aggaaacggg
    47701 tgctgcaaaa ccatctagta tggaaattgc aacaacaaat agataggtca ccaaaggcgc
    47761 tacggattgc attacggtaa acattcctac cagtatcgcc aataatatag tctttccaaa
    47821 ttgagataaa gataaaaccc tatttagcgc taacctttta gtaaccaacg gaactaaaag
    47881 actcgcaaca aaagaggata ttcctattaa gataggaact agtgatgtgg caattactga
    47941 ttttgaaata atgtatatgt tagcaatgat tgttactcta aagaaaatat ctgctaaatt
    48001 tgcaaataat tgagagacta acaacttgac aaatgaatta gacatgtagc gctccccctt
    48061 tagttacaaa ctttggaatt aaatttgatt tttaatattt tagcataaaa tagcagaaaa
    48121 caaaagtgag gttttttaca tgaaaaaaca aaaactattg cctttattat tcctaatttt
    48181 aggaggaatt atgattatcg ttgttggcta gtactaagaa gttagttagt tagttagtag
    48241 aataattaca tcttcaatcg aaaaagagac tggaaaaagt cttaaaaatc agaaaaacgc
    48301 tcaaatcctt tggcgctcta agcttttcta atgatagatt tagatagtca aaaaaatatc
    48361 tgaaaagttc ccaggatcgt cgtctcagca tcaaaaatac gtgaaatttg cataattaaa
    48421 ataaatttca ggggagttaa tcgagtaggg gataatctct agcccctctc acaccaccgt
    48481 acgtgccgtt cggcatacgg cggttcaact aacttttaac gcatgtcgtt caaggtaata
    48541 atccaaacac gaaaccagtc cacgtttttc caggactggt tttgatatag cacgtttaag
    48601 taccgacttc tgagctacta attgataatg gtcgccccag ccagatacct tatctgctat
    48661 ccatttagga actcctaact taagcaatcc ccataatcgt ctcgatttct tcttccattg
    48721 cttccagata atcactcgta ggcgagtacg caagcgctca tctatgctgg cgactatact
    48781 tttcatattt cccaatgaga aatagtttat ccatcctcga atagacaaat tcagttgctc
    48841 aatacgtctt gttaggtcta tactccattt cctctgtgtt agtttcttca atttaagctt
    48901 aaatctccga acactatctt gatgtggacg acttttccaa ccatctgatg atttccagaa
    48961 cccaaaacct agatatttca actctcttgg tctggtaatc ttagtcttgg tcatgtttac
    49021 tttcaaacct agccgttttt caataaaacg actgactgaa tacatcatac gcttagcggc
    49081 tgcctcgctt acgaccgtaa tcacacaatc atctgcgtag cgcacaaatc gaagtcccct
    49141 cttttctaat tccttgtcca attcattaag catgatattg gataagagag gagataaatt
    49201 tcctccctgt ggtgtaccaa ctagtgtttt ataacgttga ccattaatga taacacctga
    49261 atgaagatac ttacgaatca aggattccgt atctccgtct tcgataatgt tatgtactaa
    49321 ggacatcaat ctatcttgag gaactgtatc gaaaaatttc tctaggtcta tatccactat
    49381 ccactcatag ccgtcattta agtattctaa gagcttcatg atggcttttt cacatgacct
    49441 atttggtctg aaaccataac tcgtatctga gaaatggggt tcacaaatgg ggctcatgac
    49501 ttagacaatg gcctgttgaa tcattctatc cataactgtt ggaattccta gttgacggat
    49561 acctccgtct ggtttaggta tctcaactct aagaactggt tgaggcttat attttctctg
    49621 ttttatcagt tccttagtca agcgccagtt ttgtctgaga taattatcca tctcttcgat
    49681 agtcattcca tcaatcccag ctgagccttt attggatttt acttgattgt aggcttccag
    49741 catattttcg cgtgataata tcttatctag caattttgac atgtgcgtat tcctttcttg
    49801 ttttggtgcc tgagggacat cttatattgg tgagccttca tctagtcaat acgtgacaga
    49861 ctccagttct atcagacctc tcgttttaca gacacaagtg aagtaggatt acttcaatct
    49921 gtcgttttct ctttctagcg acagacctca aacagtctct ccccagactg tttgagtatt
    49981 caccccttcg ctccacttcc attacggaag tttcctcact actatgggtt cggctgactt
    50041 ctcatgattc gttgttacta cgctttcagc actcatgaga cctcacggga taagtcgtac
    50101 atctttcctc gtttatacaa gatatgagga cgttaaaagg ttacagtgaa aataggaaat
    50161 ctgacgcaga gtctttagac tctagaaaga tttatctttt cacacaaacc ttagtccgaa
    50221 ttcaattact ctcgtgattt acgcatatag gttacgacta cctttttgga ctttagagtt
    50281 tgaagcctcc ttatccgcta tatacgcctt actatcacgt tcctgttcgt agagccacga
    50341 tttcgctatc ccttcctctc cctgctacct cacgatagtc aggcttggga atcgctattg
    50401 ggttcaccgg tagcaggtgc ccaccgagga cttacacctc agatatacga catgcccgtc
    50461 gt
//
LOCUS       DAVHIZ010000008        48760 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.008, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000008 DAVHIZ010000000
VERSION     DAVHIZ010000008.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 48760)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 48760)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..48760
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.008"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            160..2793
                     /gene="polA"
                     /locus_tag="VVO18_000470"
     CDS             160..2793
                     /gene="polA"
                     /locus_tag="VVO18_000470"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase I"
                     /protein_id="HEU5585681.1"
                     /translation="MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQ
                     LMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDH
                     MGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
                     EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEG
                     IYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGK
                     FYDEMGFKQLKQALNVSSADVSESLDFTIVDQISQDMLSEESIFHFELFGENYHTDNL
                     VGFAWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAF
                     DIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKL
                     AVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIMVKKETLLEMQAENEL
                     VIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLA
                     PIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQ
                     NIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIH
                     TSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTY
                     FERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQ
                     GSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEA
                     IQLSVPLIADENEGATWYEAK"
     gene            2878..3315
                     /locus_tag="VVO18_000471"
     CDS             2878..3315
                     /locus_tag="VVO18_000471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269962.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CoA-binding protein"
                     /protein_id="HEU5585682.1"
                     /translation="MSQEFINPSDGVIRQYLATSKTLAVVGLSDREETTSNRVTKEMQ
                     ARGYKIIPVNPKAAGGEILGEKAYASLAEIPFPVDIVNVYRRSEFLPDVARDFLKADA
                     KIFWAQLGLESLEAKEILRDGGCDDIVMNRCIKREHTRLIEEA"
     gene            complement(3498..4508)
                     /locus_tag="VVO18_000472"
     CDS             complement(3498..4508)
                     /locus_tag="VVO18_000472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YeiH family putative sulfate export transporter"
                     /protein_id="HEU5585683.1"
                     /translation="MSFLSKNGAGILVCLLISIVSWYLGGFFPVIGAPVFAIFMGMLL
                     HPFLSSYKQLDVGLTFSSKKLLQYAVILLGFGLNISQVFAVGQSSLPVILSTISIALI
                     VAYLFQRFFALDTKLATLIGVGSSICGGSAIAATAPVIHAKEKEVAQAISVIFFFNVL
                     AALIFPTLGTWLHLSNDGFALFAGTAVNDTSSVTATASAWDSLYQTNTLESATIVKLT
                     RTLAIIPITLFLSYWQSREQKNKQGLQLKKVFPLFILHFILASLLTTLLTSLGVSSSF
                     FTPLKQLSKFLIIMAMSAIGLKTNLVAMVKSSGKSIVLGAVCWIAIILTSLGMQTLIG
                     IF"
     gene            4657..5826
                     /locus_tag="VVO18_000473"
     CDS             4657..5826
                     /locus_tag="VVO18_000473"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU5585684.1"
                     /translation="MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTT
                     PDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATE
                     ALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAI
                     LEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAH
                     VSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQH
                     AAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQD
                     SFAFLKDFAQKKAVAFIPGAAFGRYGECYVRLSYAASMETIKEAMKRLEEYMREA"
     gene            5823..6593
                     /gene="recO"
                     /locus_tag="VVO18_000474"
     CDS             5823..6593
                     /gene="recO"
                     /locus_tag="VVO18_000474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000616164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecO"
                     /protein_id="HEU5585685.1"
                     /translation="MIQSITSQGLVLYNRNFREDDKLVKIFTEQVGKRMFFVKHAGQS
                     KLAPVIQPLVLARFLLRINDDGLSYIEDYHEVMTFPKINSDLFVMAYATYVAALADAS
                     LQDNQQDAPLFAFLQKTLELMEAGLDYQVLTNIFEIQILTRFGISLNFNECVFCHRVG
                     QAFDFSFKYGTCLCPEHYHEDERRCHLNPNIPYLLNQFQAIDFETLETISLKPGIKQE
                     LRQFMDQLYEEYVGIHLKSKKFIDSLADWGQLLKEEKK"
     gene            6590..7582
                     /gene="plsX"
                     /locus_tag="VVO18_000475"
     CDS             6590..7582
                     /gene="plsX"
                     /locus_tag="VVO18_000475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000717456.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acyltransferase PlsX"
                     /protein_id="HEU5585686.1"
                     /translation="MKKIAVDAMGGDYAPQAIVEGVNQALSDFSDIEVQLYGDEAKIK
                     QYLTATERVSIIHTDEKIDSDDEPTRAIRNKKNASMVLAAKAVKDGEADAVLSAGNTG
                     ALLAAGFFIVGRIKNIDRPGLMSTLPTVDGKGFDMLDLGANAENTAQHLHQYAVLGSF
                     YAKNVRGIAQPRVGLLNNGTESSKGDPLRKETYELLAADESLNFIGNVEARDLMNGVA
                     DVVVADGFTGNAVLKSIEGTAMGIMGLLKTAITGGGLRAKLGALLLKDSLRGLKKQLN
                     YSDVGGAVLFGVKAPVVKTHGSSDAKAVYSTIRQIRTMLETDVVAQTAREFSGE"
     gene            7588..7821
                     /locus_tag="VVO18_000476"
     CDS             7588..7821
                     /locus_tag="VVO18_000476"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEU5585687.1"
                     /translation="MTEKEIFDRIVTIIQERQGEDFVVTESLSLKDDLDADSVDLMEF
                     ILTLEDEFSIEISDEEIDQLQNVGDVVKIIQGK"
     gene            7867..8157
                     /locus_tag="VVO18_000477"
                     /pseudo
     CDS             7867..8157
                     /locus_tag="VVO18_000477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5/IS1182 family transposase"
     gene            8360..8590
                     /gene="blpU"
                     /locus_tag="VVO18_000478"
     CDS             8360..8590
                     /gene="blpU"
                     /locus_tag="VVO18_000478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-like peptide BlpU"
                     /protein_id="HEU5585688.1"
                     /translation="MNTKKMSQFEIMDTEMLACVEGGGCNWGDFAKAGVGGGAARGLQ
                     LGIKTRTWQGAATGAAGGAILGGVAYAATCWW"
     gene            9305..11458
                     /locus_tag="VVO18_000479"
     CDS             9305..11458
                     /locus_tag="VVO18_000479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="HEU5585689.1"
                     /translation="MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKT
                     TMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTG
                     QDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
                     LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIL
                     QQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSII
                     DALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNR
                     DTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQK
                     ALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQT
                     AQVANNRLNEVYLVASEFEEKKTVEDLSLMKGDMTFKQVHYKYGYGRDVLSDINLTVP
                     QGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGSVNLNQIDKKALRQYINYLPQQ
                     PYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISG
                     GQRQRIALARALLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAE
                     RTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS"
     gene            11471..12820
                     /locus_tag="VVO18_000480"
     CDS             11471..12820
                     /locus_tag="VVO18_000480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801614.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyD family secretion protein"
                     /protein_id="HEU5585690.1"
                     /translation="MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKE
                     MSLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGDLLVQYQEGAEGVQAESY
                     ASQLDMLKDQKKQLEYLQKSLQGGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
                     ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLAGQNLAYSLYQSYK
                     SQGEENPQTKVQAVAQVEAQISQLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQ
                     HLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSSMVAEG
                     TLLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSID
                     ATATKTEKGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     gene            12990..13697
                     /locus_tag="VVO18_000481"
     CDS             12990..13697
                     /locus_tag="VVO18_000481"
                     /EC_number="6.3.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazolesuccinocarboxamide
                     synthase"
                     /protein_id="HEU5585691.1"
                     /translation="MSKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQVAG
                     KGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK
                     RFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINEL
                     LKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLG
                     ELTDVYEIVWEKLQELK"
     gene            13899..17624
                     /locus_tag="VVO18_000482"
     CDS             13899..17624
                     /locus_tag="VVO18_000482"
                     /EC_number="6.3.5.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361233.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase"
                     /protein_id="HEU5585692.1"
                     /translation="MDKRIFVEKKADFQVKSESLVREFQHNLGLSSLKSIRIVQVYDV
                     FDLAEDLFAPAEKHIFSEQVTDHVLDEVSVQADLANYAFFAIESLPGQFDQCAASSQE
                     ALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFS
                     ESDKIIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVL
                     DTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMA
                     TIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPF
                     GGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGY
                     SSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGK
                     TGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDF
                     GAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDTFVA
                     ECNKENIDAVVVATVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKL
                     PEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEA
                     SVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEVTARLVAAGANWSKARF
                     SYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLV
                     AFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEAIQADHKVT
                     SASAVKYGGVVESLALATFGNYIGAEVTLPELKTALTAQLGGFVFTSPEEIAGVEKVG
                     QTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKE
                     KVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDK
                     TNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVK
                     SGLLPYGNFEAANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVS
                     HGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQI
                     IGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK"
     gene            17717..19159
                     /locus_tag="VVO18_000483"
     CDS             17717..19159
                     /locus_tag="VVO18_000483"
                     /EC_number="2.4.2.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyltransferase"
                     /protein_id="HEU5585693.1"
                     /translation="MTYEVKSLNEECGVFGIWGHPDAAKLTYFGLHSLQHRGQEGAGI
                     LSNDQGQLKRHRDMGLLSEVFRNPANLDKLTGAGAIGHVRYATAGEASVDNIQPFLFR
                     FHDMQFGLAHNGNLTNAASLKKELEQRGAIFSATSDSEILAHLIRRSHNPSLMGKIKE
                     ALSLVKGGFAYILLFEDKLIAALDPNGFRPLSIGKMANGAVVVSSETCAFEVIGAEWI
                     RDLKPGEIVIIDDEGIQYDSYTDDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGA
                     QLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELRE
                     QGVRMKLSAVSGVVKGKRVVMVDDSIVRGTTSRRIVQLLKEAGATEVHVAIGSPALAY
                     PCFYGIDIQTRQELIAANHTVEETRQIIGADSLTYLSIDSLIESIGIETDAPNGGLCV
                     AYFDGDYPTPLYDYEEDYRRSLEEKTSFYK"
     gene            19196..20218
                     /locus_tag="VVO18_000484"
     CDS             19196..20218
                     /locus_tag="VVO18_000484"
                     /EC_number="6.3.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine cyclo-ligase"
                     /protein_id="HEU5585694.1"
                     /translation="MTNKNAYAQSGVDVEAGYEVVERIKKHVARTERAGVMGALGGFG
                     GMFDLSKTGVKEPVLISGTDGVGTKLMLAIKYDKHDTIGQDCVAMCVNDIIAAGAEPL
                     YFLDYVATGKNEPAKLEQVVAGVAEGCVQAGAALIGGETAEMPGMYGEDDYDLAGFAV
                     GVAEKSQIIDGSKVVEGDVLLGLASSGLHSNGYSLVRRVFADYTGEEVLPELEGKKLK
                     EVLLEPTRIYVKAVLPLIKEELVNGIAHITGGGFIENVPRMFADDLAAEIDESKVPVL
                     PIFKALEKYGQIKHEEMFEIFNMGVGLMLAVSPENVERVKELLDEAVYEIGRIVKKEN
                     ESVIIK"
     gene            20215..20760
                     /gene="purN"
                     /locus_tag="VVO18_000485"
     CDS             20215..20760
                     /gene="purN"
                     /locus_tag="VVO18_000485"
                     /EC_number="2.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylglycinamide formyltransferase"
                     /protein_id="HEU5585695.1"
                     /translation="MKKIAVFASGNGSNFQVIAEEFPVEFVFSDHRDAYVLERAKQLG
                     VLSYAFELKEFESKADYEAALVELLEEHQIDLVCLAGYMKIVGPTLLSAYEGRIVNIH
                     PAYLPEFPGAHGIEDAWNAGVGQSGVTIHWVDSGVDTGQVIKQVRVPRLADDTIDRFE
                     ARIHEAEYRLYPEVVKALFTD"
     gene            20844..21353
                     /locus_tag="VVO18_000486"
     CDS             20844..21353
                     /locus_tag="VVO18_000486"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000894002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanZ family protein"
                     /protein_id="HEU5585696.1"
                     /translation="MLESKKTTRYVFYVYLMLLTWGILFKFETNPEFIAFFLAPRYIN
                     WIPFSEPLIVDGKIVFAEILFNLISFIPLGVCFPLIKTNLSSLRIVGTGFLISLLFEC
                     LQYILAIGITDITDLTLNTLGVCVGLLIYQIFIRVFKSQTRKWINILGMLSLGFAYLV
                     LLLLHLIGV"
     gene            21378..22925
                     /gene="purH"
                     /locus_tag="VVO18_000487"
     CDS             21378..22925
                     /gene="purH"
                     /locus_tag="VVO18_000487"
                     /EC_number="2.1.2.3"
                     /EC_number="3.5.4.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006146083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional
                     phosphoribosylaminoimidazolecarboxamide
                     formyltransferase/IMP cyclohydrolase"
                     /protein_id="HEU5585697.1"
                     /translation="MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGV
                     DTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNL
                     YPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAAN
                     GETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENP
                     QQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHM
                     NPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSY
                     TDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQV
                     VTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQA
                     KDRLDGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFT
                     GVRHFRH"
     gene            23047..24309
                     /gene="purD"
                     /locus_tag="VVO18_000488"
     CDS             23047..24309
                     /gene="purD"
                     /locus_tag="VVO18_000488"
                     /EC_number="6.3.4.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000772208.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylamine--glycine ligase"
                     /protein_id="HEU5585698.1"
                     /translation="MKLLVVGSGGREHAIAKKLLESKDVEKVFVAPGNDGMTLDGLEL
                     VNISISEHSKLIDFAKTNDVAWTFIGPDDALAAGIVDDFNQAGLKAFGPTRAAAELEW
                     SKDFAKEIMVKYGVPTAIYGTFSDFEEAKAYIEKHGAPIVVKADGLALGKGVVVAETV
                     EQAVEAAHEMLLDNKFGDSGARVVIEEFLEGEEFSLFAFVNGDKFYIMPTAQDHKRAY
                     DGDKGPNTGGMGAYAPVPHLPQSVVDTAVDTIVKPVLEGVIKEGRPYLGVLYAGLILT
                     ADGPKVIEFNARFGDPETQIILPRLTSDFAQNITDILDSKEPNIMWTDKGVTLGVVVA
                     SKGYPLDYERGVELPAKTEGDVITYYAGAKFAENSRALLSNGGRVYMLVTTADTVKEA
                     QASIYQELSQQKIEGLFYRTDIGSKAIK"
     gene            24712..25200
                     /gene="purE"
                     /locus_tag="VVO18_000489"
     CDS             24712..25200
                     /gene="purE"
                     /locus_tag="VVO18_000489"
                     /EC_number="4.1.1.21"
                     /EC_number="5.4.99.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000805607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide mutase"
                     /protein_id="HEU5585699.1"
                     /translation="MKPVISIIMGSKSDWATMQKTAEVLDRFGVAYEKKVVSAHRTPD
                     LMFKHAEEARSRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGVDSLYSI
                     VQMPGGVPVATMAIGEAGATNAALFALRLLSVEDKSIADALANFAEEQGKIAEESSNE
                     LI"
     gene            25187..26278
                     /gene="purK"
                     /locus_tag="VVO18_000490"
     CDS             25187..26278
                     /gene="purK"
                     /locus_tag="VVO18_000490"
                     /EC_number="6.3.4.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000099033.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5-(carboxyamino)imidazole ribonucleotide
                     synthase"
                     /protein_id="HEU5585700.1"
                     /translation="MSSSKTIGIIGGGQLGQMMAISAIYMGHKVIALDPAADCPASRV
                     AEIIVAPYNDVDALRQLADRCDVLTYEFENVDADGLDAVIKDGQLPQGTDLLRISQNR
                     IFEKDFLSNKAQVTVAPYKVVTSSLDLADIDLSKNYVLKTATGGYDGHGQKVIRSEAD
                     LEAAYALADSADCVLEEFVNFDLEISVIVSGNGKEVTFFPVQENIHRNNILSKTIVPA
                     RISESLVDKAKAMAVRIAEQLNLSGTLCVEMFATDDDVIVNEIAPRPHNSGHYSIEAC
                     DFSQFDTHILGVLGAPLPVIKLHAPAVMLNVLGQHVEAAEQYVTENSSAHLHMYGKIE
                     AKHNRKMGHVTLFSDVPDSVDELGEGIDF"
     gene            26288..26515
                     /locus_tag="VVO18_000491"
     CDS             26288..26515
                     /locus_tag="VVO18_000491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270103.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole carboxylase"
                     /protein_id="HEU5585701.1"
                     /translation="MIQIIVNTFIEKDRTGAVVEVLYASADQDKVQAKYEELAAQYPE
                     NYLAIYDVPLDTDLNTLDHYPSVFIEKEEFE"
     gene            26578..27876
                     /gene="purB"
                     /locus_tag="VVO18_000492"
     CDS             26578..27876
                     /gene="purB"
                     /locus_tag="VVO18_000492"
                     /EC_number="4.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate lyase"
                     /protein_id="HEU5585702.1"
                     /translation="MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKED
                     VALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAY
                     GYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSE
                     MKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCDKLGIRAQEISTQVLPRDL
                     HAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSEN
                     MTGLARVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNL
                     TVFPENMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKLL
                     LEADSEVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD"
     gene            complement(27931..31869)
                     /gene="strH"
                     /locus_tag="VVO18_000493"
     CDS             complement(27931..31869)
                     /gene="strH"
                     /locus_tag="VVO18_000493"
                     /EC_number="3.2.1.52"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-N-acetylhexosaminidase"
                     /protein_id="HEU5585703.1"
                     /translation="MKHEKQQRFSIRKYAVGAASVLIGFAFQAQTVAADGVTTTTTEN
                     QPTIHTVSDSPQSSENRTEETPKAELQPEAPKTVETETPATDKVASLPKTEEKPQEEV
                     SSTPSDKAEVVTPTSAEKETANKKEEEASPKKEEAKEVDSKESNTDKTDKDKPAKKDE
                     AKAEADKPETETGKERAATVNEKLAKKKIVSIDAGRKYFSPEQLKEIIDKAKHYGYTD
                     LHLLVGNDGLRFMLDDMSITANGKTYDSDDVKRAIEKGTNDYYNDPNGNHLTESQMTD
                     LINYAKDKGIGLIPTVNSPGHMDAILNAMKELGIQNPNFSYFGKESARTVDLDNEQAV
                     AFTKALIDKYAAYFAKKTEIFNIGLDEYANDATDAKGWSVLQADKYYPNEGYPVKGYE
                     KFIAYANDLARIVKSHGLKPMAFNDGIYYNSDTSFGSFDKDIIVSMWTGGWGGYDVAS
                     SKLLAEKGHQILNTNDAWYYVLGRNADGQGWYNLDQGLNGIKNTPITSVPKTEGADIP
                     IIGGMVAAWADTPSARYSPSHLFKLMRHFANANAEYFAADYESAEQALNKVPKDLNRY
                     TAESVAAVKEAEKAIRSLDSNLSRAQQDTIDQAIAKLQETVNNLTLTPEAQKEEEAKR
                     EVEKLAKNKVISIDAGRKYFTLDQLKRIVDKASELGYSDVHLLLGNDGLRFLLDDMTI
                     TANGKTYASDDVKKAIIEGTKAYYDDPNGTALTQAEVTELIEYAKSKDIGLIPAINSP
                     GHMDAMLVAMEKLGIKNPQAHFDKVSKTTMDLKNEEAMNFVKALIGKYMDFFAGKTKI
                     FNFGTDEYANDATSAQGWYYLKWYQLYGKFAEYANTLAAMAKERGLQPMAFNDGFYYE
                     DKDDVQFDKDVLISYWSKGWWGYNLASPQYLASKGYKFLNTNGDWYYILGQKPEDGGG
                     FLKKAIENTGKTPFNQLASTKYPEVDLPTVGSMLSIWADRPSAEYKEEEIFELMTAFA
                     DHNKDYFRANYNALREELAKIPTNLEGYSKESLEALDAAKTALNYNLNRNKQAELDTL
                     VANLKAALQGLKPAATHSGSLDENEVAANVETRPELITRTEEIPFEVIKKENPNLPAG
                     QENIITAGVKGERTHYISVLTENGKTTETVLDSQVTKEVINQVVEVGAPVTHKGDESG
                     LAPTTEVKPRLDIQKEEIPFTTVTRENPLLLKGKTQVITKGVNGHRSNFYSVSTSADG
                     KEVKTLVNSVVAQEAVTQIVEVGTMVTHVGDENGQAAIAEEKPKLEIPSQPAPSTAPA
                     EESKALPQDPAPVVTEKKLPETGTHDSAGLVVAGLMSTLAAYGLTKRKED"
     gene            complement(32185..32901)
                     /locus_tag="VVO18_000494"
     CDS             complement(32185..32901)
                     /locus_tag="VVO18_000494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001007200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU5585704.1"
                     /translation="MAIPKYQYIKDELKNKIISGQFSSGDKFYTEAELISMYDVSSIT
                     VVRALNDLAKDGYIVRQQGKGTFISRARKHKLVEFSDIELFNAKDDKVTVLSIERGNK
                     LVYLEKLGLRGDQFYYKIERIRESNGVVYIYHTSYIPEQYINANYPNLEYYSSIYNRF
                     KLDYHIHMNDEHFEEINEIVFPTPEHAASVLGVDEHFPTVLQTKITKLESTGQVLEYS
                     ETYKRSDYYKIKFISCDRDH"
     gene            33249..35036
                     /locus_tag="VVO18_000495"
     CDS             33249..35036
                     /locus_tag="VVO18_000495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262529.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-galactosidase"
                     /protein_id="HEU5585705.1"
                     /translation="MTRFEIRDDFYLDGKSFKILSGAIHYFRVPPEDWYHSLYNLKAL
                     GFNTVETYVAWNLHEPREGEFHFEGDLDLEKFLQIAQDLGLYAIVRPSPFICAEWEFG
                     GLPAWLLTKNMRIRSSDPAYIEAVGRYYDQLLPRLVPRLLDNGGNILMMQVENEYGSY
                     GEDKAYLRAIRQLMEECGVTCPLFTSDGPWRATLKAGTLIEEDLFVTGNFGSKAPYNF
                     SQMQEFFDEHGKKWPLMCMEFWDGWFNRWKEPIITRDPKELADAVREVLEQGSINLYM
                     FHGGTNFGFMNGCSARGTLDLPQVTSYDYDALLDEEGNPTAKYLAVKKMMATHFSEYP
                     QLEPLYKESMELDAIPLVEKVSLFETLDSLSSPVESLYPQKMEELGQSYGYLLYRTET
                     NWDAEEERLRIIDGRDRAQLYVDGQWVKTQYQTEIGEDIFYQGKKKGLSRLDILIENM
                     GRVNYGHKFLADTQRKGIRTGVCKDLHFLLNWKHYPLPLDNPEKIDFSKGWTQGQPAF
                     YAYDFTVEEPKDTYLDLSEFGKGVAFVNGQNLGRFWNVGPTLSLYIPHSYLKEGANRI
                     IIFETEGQYKEEIHLTRKPTLKHIKGENL"
     gene            35033..35509
                     /locus_tag="VVO18_000496"
     CDS             35033..35509
                     /locus_tag="VVO18_000496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155184.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEU5585706.1"
                     /translation="MTIVGCRIDGRLIHGQVANLWAGKLNVSRIMVVDDEVVNNDIEK
                     SGLKLATPPGVKLSILPVEKAAANILAGKYDSQRLFIVARKPDRFLGLVEAGVPLETL
                     NVGNMSQTPETRSITRSINVVDKDVEDFHKLAEKGVKLTAQMVPNDPISDFLSLLK"
     gene            35537..36442
                     /locus_tag="VVO18_000497"
     CDS             35537..36442
                     /locus_tag="VVO18_000497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEU5585707.1"
                     /translation="MIQWWQILLLTLYSAYQICDELTIVSSAGSPVFAGFITGLIMGD
                     VTTGLLIGGNLQLFVLGVGTFGGASRIDATSGAVLATAFSVSQGIDAPLAITTIAVPV
                     AALLTYFDVLGRMTTTFFAHRVDAAIERFDYKGIERNYLLGAIPWALSRALPVFFALA
                     FGGAFVQSVVDFVEAYKWVADGLTLAGRMLPGLGFAILLRYLPVKRNLHYLAMGFGLT
                     AMLTVLYSYVTGLGGAVAGIVGTLPAEVAEKIGFVNNFKGLSMIGISIVGIFLAVLHF
                     KNSQKVAVAAPSTPSESGEIEDDEF"
     gene            36429..37244
                     /locus_tag="VVO18_000498"
     CDS             36429..37244
                     /locus_tag="VVO18_000498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU5585708.1"
                     /translation="MTNSNYKLTKEDFNQINKRSLFTFQLGWNYERMQASGYLYMILP
                     QLRKMYGDGTPELKEMMKVHTQFFNTSPFFHTIIAGFDLAMEEKDGVGSKDAVNGIKT
                     GLMGPFAPLGDTIFGSLVPAIMGSVAATMAIAGQPWGIFLWIAVAVAYDIFRWKQLEF
                     AYKEGVNLINNMQSTLTALIDAASVLGVFMMGALVATVINFEISYKLPIGEKMIDFQD
                     ILNQIFPRLLPAIFTAFIFWLLGKKGMNSTKAIGIIIVLALALSALGHFALGM"
     gene            37251..37655
                     /locus_tag="VVO18_000499"
     CDS             37251..37655
                     /locus_tag="VVO18_000499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007284837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5585709.1"
                     /translation="MTKSLILVSHGRFCEELRGSTEMIMGPQDNIYTVALLPEDGPEE
                     FTAKFEAVIEGLDDFLVFADLLGGTPCNVVSRLIMEGRDIDLYAGMNLPMVIEFINAS
                     LTGADADYKSRAAESIVKVNDLLAGFDDDEDE"
     gene            37954..39120
                     /locus_tag="VVO18_000500"
     CDS             37954..39120
                     /locus_tag="VVO18_000500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="HEU5585710.1"
                     /translation="MLHYTKEDLLELGAEITTREIYQQPDVWREAFEFYQAKREEIAA
                     FLQEIADKHDYIKVILTGAGTSAYVGDTLLPYFKEVYDERKWNFNAIATTDIVAKPAT
                     YLKKDVATVLVSFARSGNSPESVATVDLAKSLVDELYQVTITCAADGKLALQAHGDDR
                     NLLLLQPAVSNDAGFAMTSSFTSMMLTALLVFDPTEFAVKSERFEVVSSLARKVLDKA
                     EDVKELVDLDFNRVIYLGAGPFFGLAHEAQLKILELTAGQVATMYESPVGFRHGPKSL
                     INDNTVVLVFGTRTDYTRKYDLDLVREVAGDQIARRVVLLSDQAFGLENVKEVVLGCG
                     GVLNDIYRVFPYIVYAQLFALLTSLKVENKPDTPSPTGTVNRVVQGVIIHEYQK"
     gene            39236..40273
                     /locus_tag="VVO18_000501"
     CDS             39236..40273
                     /locus_tag="VVO18_000501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose mutarotase"
                     /protein_id="HEU5585711.1"
                     /translation="MKAYTERVFGNVEGEDVLAYRFETDGGYQLEVMTYGATILRYVA
                     PDKAGNFANVILGFDDFDSYVGNSPKHGASVGPVAGRIAGATFELNGKTYDLEVNNAS
                     NCNHSGSTGWDSSLFEVEEVSDHGLTLYTERTDGTGGFPGNLKIWISYHLEETGAYEI
                     SYKVTTDQDTLVNPTNHSYFNLSGDFTQTIDRHVFQLNTEGIYSIAPDGVPAKTPEAN
                     RDVVKHIYNGALLKDIFAEEDEQIQLASGLDHPFALPAGHDNAGFLYDQNSGRFLLFK
                     TEAPCFVVYTANFVDESVIIGGQPMLQHNGIALEAQALPDAIHSDLKGQVILKAGQTF
                     TSKTRYELVVK"
     gene            40479..41333
                     /locus_tag="VVO18_000502"
     CDS             40479..41333
                     /locus_tag="VVO18_000502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000220702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family protein"
                     /protein_id="HEU5585712.1"
                     /translation="MTYEYKSHIYLAETVLNVKDLASQTAFYQQVIGLEILSQTETES
                     ILGLGGKVLVQLIQAQESGEVREHYGLYHLAILLPTRKALADVLKHLTDLQIPLVGGA
                     DHGYSEAIYLEDLEGNGIELYRDKPVSTWDIREDGRIIGVTEALAAQDIYELGERVEP
                     FILAEGTRMGHIHLSVKDSRKSSQFYQKVLGLENKFSVPGASWIAAGDYHHHLAVNEW
                     GGKGLASRKQGLPGLAYYVIEVAHKKELLTIAQRAQEVDAPIKWMTSIQLEITDSDGI
                     VTRIRLAR"
     gene            41483..41740
                     /locus_tag="VVO18_000503"
     CDS             41483..41740
                     /locus_tag="VVO18_000503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001845567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="HEU5585713.1"
                     /translation="MTNSKYITCLKRSEGQLCGIQKMIEGDRDCADIVTQLTAVRSSV
                     ERVIEMIITENLTECINQPLDDSEAQKERLEKAIRYLIKRK"
     gene            complement(41953..42036)
                     /locus_tag="VVO18_000504"
                     /pseudo
     CDS             complement(41953..42036)
                     /locus_tag="VVO18_000504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004238277.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lysyl-tRNA synthetase"
     gene            complement(42070..42162)
                     /locus_tag="VVO18_000505"
                     /pseudo
     CDS             complement(42070..42162)
                     /locus_tag="VVO18_000505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(42198..42494)
                     /locus_tag="VVO18_000506"
     CDS             complement(42198..42494)
                     /locus_tag="VVO18_000506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU5585714.1"
                     /translation="METSISMADFYGKYQNENLELIDVREAHEFQAGHAPGAKNLPLS
                     TLEQGYKELKPDHEYYVICQGGVRSASTCQFLSSQGLTVTNVEGGMNAWPGQVE"
     gene            complement(42484..42645)
                     /locus_tag="VVO18_000507"
     CDS             complement(42484..42645)
                     /locus_tag="VVO18_000507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014932007.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(FAD)-dependent dehydrogenase"
                     /protein_id="HEU5585715.1"
                     /translation="MDKKQAYIVSCHSGLRSYIAEPILKQAGFTAQNLDGAYSLYKMV
                     NPEGVEYGN"
     gene            42715..43479
                     /locus_tag="VVO18_000508"
     CDS             42715..43479
                     /locus_tag="VVO18_000508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside phosphorylase"
                     /protein_id="HEU5585716.1"
                     /translation="MIQKHAIPILEFDDNPQAVIMPNHEGLDLQLPKKCVYAFLGEEI
                     DRYAREVGANCVGEFVSATKTYPVYVINYKGEEVCLAQAPVGSAPAAQFMDWLIGYGV
                     EQIISTGTCGVLADIEENAFLVPVRALRDEGASYHYVAPCRYMEMQPEAIAAIEEVLE
                     DRGIPYEEIMTWTTDGFYRETAEKVAYRKEEGCAVVEMECSALAAVAQLRGVLWGELL
                     FTADSLADLDQYDSRDWGSEAFNKALELSLASVHHL"
     gene            complement(43719..43871)
                     /locus_tag="VVO18_000509"
     CDS             complement(43719..43871)
                     /locus_tag="VVO18_000509"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585717.1"
                     /translation="MRTKASLRKLVTGYSKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NIYTAR"
     gene            44089..45468
                     /locus_tag="VVO18_000510"
     CDS             44089..45468
                     /locus_tag="VVO18_000510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000897732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEU5585718.1"
                     /translation="MLFKLSKEKIELGLSRLSPARRIFLSFALVILLGSLLLSLPFVQ
                     VESSRATYFDHLFTAVSAVCVTGLSTLPVAHTYNIWGQIICLLLIQIGGLGLMTFIGV
                     FYIQSKQKLSLRSRATIQDSFSYGETRSLRKFVYSIFLTTFLVESLGAILLSFRLIPQ
                     LGWGRGLFSSIFLAISAFCNAGFDNLGSTSLFAFQTDLLVNLVIAGLIITGGLGFMVW
                     FDLAGHVGRKKKGRLHFHTKLVLLLTIGLLLFGTATTLFLEWNNAGTIGNLPVADKVL
                     VSFFQTVTMRTAGFSTIDYTQAHPVTLLIYILQMFLGGAPGGTAGGLKITTFFVLLVF
                     ARSELLGLPHANVARRTIASRTVQKSFSVFIIFLMSFLIGLILLGITAKGNPPFIHLI
                     FETISALSTVGVTANLTPDLGKLALSVIMPLMFMGRIGPLTLFVSLADYHPEKKDMIH
                     YMKADISIG"
     gene            45482..46147
                     /locus_tag="VVO18_000511"
     CDS             45482..46147
                     /locus_tag="VVO18_000511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001283913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkA family potassium uptake protein"
                     /protein_id="HEU5585719.1"
                     /translation="MSDRTIGILGLGIFGSSVLAALAKQDMNIIAIDDHAERINQFEP
                     VLARGVIGDITDEELLRSAGIDTCDTVVVATGENLESSVLAVMHCKSLGVPTVIAKVK
                     SQTAKKVLEKIGADSVISPEYEMGQSLAQTILFHNSVDVFQLDKNVSIVEMKIPQSWA
                     GQSLSKLDLRGKYNLNILGFREQENSPLDVEFGPDDLLKADTYILAVINNQYLDTLVA
                     LNS"
     gene            46282..46440
                     /locus_tag="VVO18_000512"
     CDS             46282..46440
                     /locus_tag="VVO18_000512"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585720.1"
                     /translation="MKIKDQTRKLATGCSKHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     NIYTARRR"
     gene            46502..47041
                     /locus_tag="VVO18_000513"
     CDS             46502..47041
                     /locus_tag="VVO18_000513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5585721.1"
                     /translation="MKLLSIAISSYNAAAYLHYCVESLVIGGEQVGILIINDGSQDQT
                     QEIAECLASKYPNIVRAIYQKNKCHGGAVNRGLAEASGRYFKVVDSDDWVDPRAYLKI
                     LETLQELESKGQEVDVFVTNFVYEKEGQSRKKSMSYDSVLPVRQIFGWDQVGNFSKGQ
                     YTMMHSLIYRTALLRASQF"
     gene            47108..47518
                     /locus_tag="VVO18_000514"
     CDS             47108..47518
                     /locus_tag="VVO18_000514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262849.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 2"
                     /protein_id="HEU5585722.1"
                     /translation="MYYLPVDFYRYLIGREDQSVNEQVMIKCIDQQLKVNRLLVDQLD
                     LSQVSHPKMREYLLNHIEITTVISSTLLNRSETAEHLAKKRQLWTYIQQENPKVFQAI
                     RKTMLSRLTKHSVLPDRKLSNVVYQITKSVYGFN"
     gene            47634..>48760
                     /gene="pavB"
                     /locus_tag="VVO18_000515"
     CDS             47634..>48760
                     /gene="pavB"
                     /locus_tag="VVO18_000515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat adhesin PavB"
                     /protein_id="HEU5585723.1"
                     /translation="MKFNPNQRYTRWSIRRLSVGVASVVVASGFFVLVGQPSSVRADV
                     VNPTPGQVLPEETSGTKEGDLSEKPGDTVLTQAKPEGVTGNTNSLPTPTERTEVSEET
                     NSSSLDTLFEKDEEAQENPELTDALKETVDTADVDGTQASPAETTPEQVKGGVKENTK
                     DSIDVPAAYLEKAEGKGPFTAGVNQVIPYELFAGDGMLTRLLLKASDNAPWSDNGTAK
                     NPALPPLEGLTKGKYFYEVDLNGNTVGKQGQALIDQLRANGTQTYKATVKVYGNKDGK
                     ADLTNLVATKNVDININGLVAKETVEKAVKDNVKDSIDVPAAYLEKAKGEGPFTAGVN
                     HVIPYELFAGDGMLTRLLLKASDKAPWSDNGEAKNPALSPLG"
BASE COUNT        13553 a         9365 c        11574 g        14268 t
ORIGIN      
        1 tgtactatta tagattcaat atactatatt atagcacatt tttaaatcta ggtttactaa
       61 attctctggc tctatctatt tattcggaaa aagtttgaaa aatacttgct ctagctcttc
      121 ccaatggtat tttttgattc tttcctttat aatgggtgta tggataagaa aaaattatta
      181 ttgattgatg ggtcttctgt agcttttcgg gcgttttttg cgctgtatca gcagttggac
      241 cgttttaaga atgcggctgg tttgcatacc aatgcgattt atggttttca gttgatgttg
      301 agtcatttgt tggagcgggt tgagccgagt catattttgg tggcttttga tgcgggaaag
      361 acgaccttcc ggacagagat gtatgcggac tataagggtg gtcgggccaa gactcctgat
      421 gagtttcgtg agcaatttcc tttcattcgt gagttgctgg atcatatggg gattcgtcac
      481 tatgagctgg ctcagtatga ggcggatgac atcattggga cgctggataa gctagcagag
      541 caggatggtt ttgatattac cattgtcagt ggggacaagg atttgattca gctgacggat
      601 gagcatacgg tggttgaaat ttccaagaaa ggtgtggctg agtttgaggc ctttacgcca
      661 gattacctca tggaagaaat gggcctcaca ccagctcagt ttatcgatct caaggcgctc
      721 atgggtgata agtcggataa tatccctggg gtgaccaaag tcggtgaaaa gacgggtatt
      781 aagctcttgc tggagcatgg ttcgcttgag gggatttatg aaaatattga tggaatgaag
      841 acttctaaga tgaaggaaaa tctcatcaat gacaaggaac aggccttttt atctaaaaca
      901 ctagcgacca ttgataccaa ggcaccgatt gcgattggtt tagaggactt ggtctatagt
      961 ggtccagatg ttgaaaatct tgggaaattc tacgatgaga tgggcttcaa acagctaaag
     1021 caggctttaa atgtgtcgtc agctgatgtg tctgagagtt tggattttac tattgttgac
     1081 caaatcagtc aagatatgct gagtgaagag tctatcttcc actttgagct ttttggtgag
     1141 aattaccata cggataattt ggttggattt gcctggtctt gtggggataa gctctatgcc
     1201 acagacaagc ttgagctgtt gcaagacccg attttcaagg atttcttaga aaaaacatct
     1261 ctgagagttt atgactttaa gaaggttaaa gttcttttgc aacgttttgg tgtggatttg
     1321 caggcgcctg cttttgacat ccgtttggct aaatacctcc tttcgactgt ggaggacaat
     1381 gaaattgcga ccatcgctag tctttatggt cagacttact tggttgatga tgaaactttc
     1441 tacggtaagg gtgttaaaaa ggccattcct gaacgtgaga aattcttgga acacttagct
     1501 tgtaaacttg ctgttttggt agaaacagag cctattttac ttgaaaaact cagcgaaaat
     1561 gggcaattag agcttcttta tgatatggag caacctctgg cttttgtcct tgccaagatg
     1621 gaaattgctg ggattatggt caagaaagag accttgcttg agatgcaggc tgaaaatgag
     1681 cttgtcattg aaaaactgac tcaagagatt tacgagctgg ctggtgagga gtttaatgtc
     1741 aactcgccta agcagttggg cgtgcttctc tttgagaaat tgggacttcc tctagaatac
     1801 actaagaaaa ccaagacagg ttattcgaca gcagtggatg tgttggagcg tctcgctcct
     1861 attgctccga ttgttaagaa aatcctggat taccgtcaaa ttgctaagat tcaatctact
     1921 tatgtaattg gcttgcagga ctggattttg gctgatggaa agattcatac tcgctatgtg
     1981 caggatttga cccagaccgg gcgtttgtct agtgtggatc caaacttgca aaatattcct
     2041 gcccgattgg aacaggggcg cttgattcgg aaggcttttg tgccagagtg ggaggatagt
     2101 gtgctactca gctctgacta ttcacagatt gaattgcgcg ttttggcgca tatttctaag
     2161 gatgagcact tgattaaggc cttccaagag ggggcagata tccatacttc gacagccatg
     2221 cgggtctttg gcattgagcg tcctgatgat gtgactgcaa acgaccgtcg caatgccaag
     2281 gcagttaact ttggagtggt ttatgggatt tcagactttg gcttgtctaa taatttggga
     2341 attagtcgta aggaagccaa agcctacatt gatacctact ttgaacgttt tccaggtatt
     2401 aaaaactaca tggatgaagt ggtgcgggag gcgcgtgata agggctatgt agagaccctc
     2461 tttaagcgtc gccgtgagtt gccagatatc aattcgcgca acttcaatat tcgtggtttt
     2521 gcggagcgaa ctgctatcaa ctcacctatc cagggttcgg cagcagatat tctcaagatt
     2581 gccatgattc agctggataa agccttggtt gcaggtggtt atcagactaa gatgctgtta
     2641 caagtgcacg atgaaatcgt ccttgaagtg cctaaatctg aattggtaga gatgaaaaaa
     2701 ttggtgaaac aaaccatgga agaagccatt caactcagtg ttcctcttat cgcagatgag
     2761 aatgaagggg caacctggta cgaggctaaa taaaaagggg gctagtcctc cttttttgta
     2821 gtataattct gcaaaccttt tcaaaatgtg ctatactgat gaaaaaggag gatttctatg
     2881 agtcaagaat ttatcaatcc aagtgatggc gtgattcgtc agtatctcgc aacgagtaaa
     2941 acccttgctg tggtgggttt gtctgaccgt gaagaaacaa ccagcaatcg agtaacaaag
     3001 gaaatgcagg ctcggggcta taaaatcatc ccagtcaatc ccaaggcggc aggtggcgaa
     3061 atcttgggtg aaaaggctta tgctagcctc gctgaaattc cttttcctgt agatattgtc
     3121 aatgtttatc gtcgcagtga atttctgccc gatgtggcgc gtgattttct caaagctgat
     3181 gccaagattt tttgggcaca gctaggactt gaaagtttag aagcgaaaga gattttgcgt
     3241 gatggtggat gtgatgatat cgtgatgaat cgctgtatca agagagaaca tactcgcttg
     3301 attgaggaag cataagaaaa aggtagctga tgggctacct tttgtgttat actcaatgaa
     3361 aatcaaagag caaactagga aactagccgc gggctgctca aaacaccgtt ttgaggttgc
     3421 agatagaact gacgaagtca gtaacatata tacggcaagg cgacgttgac gtggtttgaa
     3481 gagattttcg aagagtatta gaaaatgccg ataagggtct gcataccaag gctggtgagg
     3541 atgatggcaa tccagcagac ggctccgaga acaatggatt ttccactgga tttgaccata
     3601 gcgaccagat tagttttgag accgatggca ctcatggcca tgataatgag gaatttagag
     3661 agttgtttga gaggggtaaa gaaactacta gacacaccga gagaggtcag aagggtggtt
     3721 aggagcgatg caaggatgaa gtgaaggata aaaagtggga agactttttt cagttgtaag
     3781 ccttgcttat ttttttgctc gcgactttgc cagtaggaga gaaagagagt gatggggatg
     3841 atagctaggg ttcgcgtgag tttgacaatg gttgcggatt cgagggtatt ggtctggtag
     3901 agactgtccc aagcgctagc tgtggcggtt acagaggaag tatcattgac cgcagttcct
     3961 gcaaagaggg cgaagccgtc attggataga tgaagccagg tgccgagggt tggaaagatg
     4021 agcgcagcca agacattgaa gaaaaagata acggagatgg cttgggctac ttccttttcc
     4081 ttagcatgga taacaggcgc tgtcgctgca atggcagaac ccccacagat agaagaacct
     4141 actccaatca aggtagccag ttttgtatcc agggcaaaga agcgctggaa gaggtaggca
     4201 acaatcaagg ctattgaaat ggtggaaagg atgacaggga gtgaagattg cccaactgcg
     4261 aagacttgag agatattgag accaaaacca agcaagataa cggcatactg gagcaatttc
     4321 ttggaactaa aggtcaatcc aacatccagt tgtttataag acgagagaaa gggatgtagg
     4381 agcatgccca taaaaatcgc aaaaacgggc gcgccaatca cagggaagaa tcctcctaag
     4441 taccaagata cgatagaaat gagaaggcag accaagatgc ctgctccatt ttttgataga
     4501 aatgacataa aaacctccaa atagaatctg ttaccattat agacctgtaa acaggaaaag
     4561 taaaatagaa agtggaaagc tattctctaa tgtatttttg cggtcggggg gcttttgtag
     4621 tataatagag atacgttttg aaagtaggag gtatctatgg acttaactaa gcgctttaat
     4681 aaacagttag ataaaattca agtttcgttg attcgtcagt ttgaccaggt tatttcggag
     4741 attcctgggg tcttgcgttt gaccttgggg gaacctgatt ttacaacgcc agaccatgtc
     4801 aaggaggcgg ccaagcgagc gattgatcag aaccaatcct actatacagg gatgagtggt
     4861 ctgctgactc tacgtcaggc ggccagtgat tttgttaagg aaaagtacca actggactat
     4921 gctcctgaaa atgaaatctt ggtcactatc ggagcgacag aggctttatc tgcgactttg
     4981 acggctattt tggaagaggg agacaaggtg ctcttgccag ctcctgctta tccgggttat
     5041 gaaccgattg tcaatctagt tggggcagaa attgttgaga ttgatacgac tgaaaatggt
     5101 tttgtcttga ctcctgagat gttggagaag gccattttgg agcagggtga taagctcaag
     5161 gcggttattc tcaactatcc agccaatccg acaggaatta cctacagtcg agagcagtta
     5221 gaggccttgg cagctgtttt acgcaagtac gaaatttttg ttgtctgtga tgaggtttac
     5281 tcagaattga cctacacagg cgaagcccat gtgtctctag gaacgatgtt gagagaccag
     5341 gctattatta tcaatggttt gtctaaatcg catgccatga caggttggcg tttggggctg
     5401 attttcgctc ctgcggcctt cacagcccag ttaatcaaga gtcaccaata cttggtcact
     5461 gccgcaaata ccatggcgca acatgctgcg gtagaagcct tgacggctgg taaaaatgat
     5521 gcggagccca tgaagaagga atatatccag cgtcgggact atatcatcga aaaaatgact
     5581 gctcttggtt ttgagattat caaaccagac ggtgccttct atatttttgc taaaattcca
     5641 gcgggctaca atcaagactc ctttgctttt ctgaaggatt ttgctcagaa gaaggccgtt
     5701 gcctttatcc ctggtgcagc ctttggacgt tacggggaat gctacgtccg cctatcttat
     5761 gcagccagca tggagactat caaagaagcc atgaaacgac ttgaggagta catgagagaa
     5821 gcatgattca gtctatcacg agtcaaggct tggtgcttta caatcgcaat tttcgtgagg
     5881 atgacaagct cgtcaaaatt tttacagagc aggttggcaa acgcatgttt tttgtcaaac
     5941 acgctggtca gtctaagctg gcgcctgtta ttcagccctt ggtgctggca cgatttctct
     6001 tgcgaatcaa tgatgacgga ctcagttaca tcgaagacta tcatgaggtc atgacttttc
     6061 ccaagattaa tagtgacctc tttgtcatgg cctatgcgac ctatgtggca gctcttgcag
     6121 atgctagttt gcaggacaat cagcaggatg ctcccttgtt tgcttttttg caaaagactt
     6181 tggagttgat ggaagcaggc ttggattatc aggttttgac caatattttt gaaattcaaa
     6241 ttttgactcg atttggaatc agcctcaatt ttaatgagtg tgtcttttgc catcgggttg
     6301 gtcaggcttt tgacttttct ttcaaatatg gaacctgtct ctgtccagag cattatcatg
     6361 aggatgagag acgttgccat ctcaatccca atatccccta tctgctcaat caatttcaag
     6421 ctattgattt tgagactttg gagaccattt cgctcaagcc tggaatcaag caagagctac
     6481 gccaatttat ggatcaacta tatgaagagt acgttgggat tcacctaaaa tcaaagaaat
     6541 ttattgattc cctagcagac tggggacaat tactaaaaga ggaaaagaaa tgaaaaaaat
     6601 cgcagtagat gccatggggg gcgattacgc acctcaggcc atcgttgagg gtgtcaatca
     6661 agccctatct gacttttcag atatcgaggt tcaactctac ggagatgaag ctaaaatcaa
     6721 gcaatatctg acagcgacag agcgcgtcag cattatccat acggatgaga agattgattc
     6781 ggatgatgaa cctacgagag ctattcggaa taagaaaaat gccagtatgg tattggcagc
     6841 caaggctgtc aaagatggtg aagcagacgc tgtcctttcg gctgggaata caggtgcttt
     6901 gttggctgct ggattcttca tcgtgggtcg tatcaagaat atcgaccgtc ctggacttat
     6961 gtcaacattg ccgactgtag atgggaaagg ttttgacatg cttgacctcg gtgctaatgc
     7021 agaaaataca gcccagcacc tccatcaata cgctgtccta ggttctttct atgccaagaa
     7081 tgttcgtggc attgcgcaac cacgcgttgg cttgcttaac aacggaacag agagtagcaa
     7141 gggcgacccg cttcgtaagg aaacttatga attactggcg gctgatgaaa gtttgaactt
     7201 tatcggaaac gtggaagcgc gtgatttgat gaatggcgtt gcagatgttg ttgtggcaga
     7261 tggtttcacg ggaaacgctg tgctcaaatc catcgaaggg acagctatgg gaatcatggg
     7321 cttgctcaag acagctatta caggtggtgg tcttcgagcg aaactaggtg ccctccttct
     7381 caaggacagc ctcagaggtt tgaaaaaaca gctcaattat tcagatgttg gtggagcggt
     7441 cttgtttggt gttaaggcac ctgttgtcaa gactcatggc tcaagcgatg ccaaggctgt
     7501 ttatagtacg attcgtcaga tccgtaccat gctagaaaca gacgtggttg cccagactgc
     7561 gcgtgaattt tcaggagaat aaaagagatg acagaaaaag aaatttttga ccgtattgtg
     7621 accattatcc aagagcgaca gggagaggac tttgtcgtga cagaatcctt gagtctgaaa
     7681 gacgatttgg atgcggattc tgttgacttg atggagttta tcttgactct ggaagatgaa
     7741 tttagtatcg aaatcagcga tgaagaaatt gaccaactcc aaaacgtagg agatgtggtt
     7801 aaaatcattc aaggaaaata gcaatcggag ttccaagtca acggaagtag atggttttta
     7861 gaaatgagaa atatcggaca agctggtaaa atcttggctg acagtggtta tcaagggctc
     7921 atgaagatat atcctcaagc acaaactcca cgtaaatcca gcagactcaa gccgctaaca
     7981 gttgaagata aagcctgtaa tcatgcgcta tctaaggaga taagcaaggt tgagaatatc
     8041 tttgccaaag taaaaacgtt taaaatgttt tcaacaacct atcgaaatca tcgtaaacgc
     8101 ttcggattac gaatgaattt gattgctggt attatcaatc atgaactagg attctagttt
     8161 tgcaggaagt ctaatagtaa aaaagtgatt agaaaacatc ttttttaaaa atagagatga
     8221 ttttgaaaca aaaaagctaa ttcaagacgt ttcgatgcca attcaagatt tggatgaaaa
     8281 aaattaatag atactgttat actaaacttg tcaagtttgt aacaagacaa atattaaaaa
     8341 taaaaaagag gtattcgtta tgaatacaaa aaagatgtca caatttgaaa ttatggatac
     8401 tgagatgctt gcttgcgttg aaggtggcgg atgcaattgg ggagattttg ccaaagcagg
     8461 tgttggagga ggagcagcac gaggtcttca gctaggaatt aaaacaagaa catggcaagg
     8521 tgcagcaact ggtgctgcgg gaggagctat acttggaggt gtggcctatg cagcgacatg
     8581 ttggtggtaa ttatggattt taaaagtttt attattggtt tagtagttgg tatatttggt
     8641 ccttatatgg atgatttaat tagaaaaaaa tttttaaagt cttcggagaa gaaaacagaa
     8701 aaatctgtta aaaaataatc aaaactataa atgatgaatc tgaatcaaaa ttattttgcg
     8761 catgtaaaga ggagtcttat agtaacgagt caaaaaagga gtaactatga atcgtaattt
     8821 agaacggtgt tatctattct gactaggaat agatcatacc agaggtagct tagaaatagc
     8881 agagacatta gaaattgaag taataaatag gatgtcgtaa gtgttactat caatgattta
     8941 tttgtttcaa gcttgcctag ggtgacagta aaaaatcaat ttcctttcaa tagcatattt
     9001 ttagtgggca ggactcttgt tctgcctatt tttttatcca aaaagtgcag ttgggaggga
     9061 gataggcgca tttgggaagg aagtccagtt tttgtttagt gattggggta agatagttgt
     9121 tatcagatga gtttatactc ttcgaaaatc aaattcaaac cacgtcaacg tcgccttgcc
     9181 gtatatatgt gactgacttc gtcagtccta tctacaacct caaaacagtg ttttgagcag
     9241 cctgcggcta gtttcctagt ttgctctttg attttcattg agtattaggg aaaaggagat
     9301 gaatatgaaa tttgggaaac gtcactatcg tccgcaagtg gatcagatgg actgcggtgt
     9361 agcttcatta gccatggttt ttggctacta tggtagttat tattttttgg ctcacttgcg
     9421 agaattggct aagacgacca tggatgggac gacggctttg ggcttggtca aggtggcaga
     9481 ggagattggt tttgagacgc gagccattaa ggcggatatg acgctttttg acttgccgga
     9541 tttgactttt ccttttgttg cccatgtgct taaggaaggg aaattgctcc actactatgt
     9601 ggtgactggg caggataagg atagcattca tattgccgat ccagatcccg gggtgaagtt
     9661 gactaaactg ccacgtgagc gttttgagga agaatggaca ggagtgactc tttttatggc
     9721 acctagtcca gactataagc ctcataagga acaaaaaaat ggtctgctct cttttatccc
     9781 tatattagtg aagcagcgtg gcttgattgc caatatcgtt ttggcaacac tcttggtaac
     9841 cgtgattaac attgtgggtt cttattatct gcagtctatc attgatacct atgtgccaga
     9901 tcagatgcgt tcgacactag ggattatttc tattgggcta gtcatcgtct acatcctcca
     9961 gcaaatcttg tcttacgctc aggagtatct cttgcttgtt ttggggcaac gcttgtcgat
    10021 tgacgtgatt ttgtcctata tcaagcatgt ttttcacctc cctatgtcct tctttgcgac
    10081 acgcaggaca ggggagatcg tgtctcgttt tacagatgct aacagtatca tcgatgcgct
    10141 ggcttcgacc atcctttcga ttttcctaga tgtgtcaacg gttgtcatta tttcccttgt
    10201 tctattttca caaaatacca atctcttttt catgacttta ttggcgcttc ctatctacac
    10261 agtgattatc tttgccttta tgaagccgtt tgaaaagatg aatcgggata ccatggaagc
    10321 caatgcggtt ctgtcttctt ctatcattga ggacatcaac ggtattgaga ctatcaagtc
    10381 cttgaccagt gaaagtcagc gttaccaaaa aattgacaag gaatttgtgg attatctgaa
    10441 gaaatccttt acctatagtc gagcagagag tcagcaaaag gctctgaaaa aggttgccca
    10501 tctcttgctt aatgtcggca ttctctggat gggggctgtt ctggtcatgg atggcaagat
    10561 gagtttgggg cagttgatta cctataatac cttgctggtt tactttacca atcctttgga
    10621 aaatatcatc aatctgcaaa ccaagcttca gacagcgcag gttgccaata accgtctaaa
    10681 tgaagtgtat ctagtagctt ctgagtttga ggaaaagaaa acagttgagg atttgagctt
    10741 gatgaaggga gatatgacct tcaagcaggt tcattacaag tatggctatg gtcgagacgt
    10801 cttgtcggat atcaatttaa ccgttcccca agggtctaag gtggcttttg tggggatttc
    10861 agggtcaggt aagacgactt tggccaagat gatggttaat ttttacgacc caagtcaagg
    10921 ggagattagt ctgggtagtg tcaatctcaa tcagattgat aaaaaagccc tgcgccagta
    10981 catcaactat ctgcctcaac agccctatgt ctttaacgga acgattttgg agaatcttct
    11041 tttgggagcc aaggagggga cgacacagga agatatctta cgggcggtcg aattggcaga
    11101 gattcgagag gatatcgagc gcatgccact gaattaccag acagaattga cttcggatgg
    11161 ggcaggaatt tcaggtggtc aacgtcagag aatcgctttg gcgcgtgctc tcttgacaga
    11221 tgcgccggtc ttgattttgg atgaggcgac tagcagtttg gatattttga cagagaagcg
    11281 gattgtcgat aatctcatgg ctttggacaa gaccttgatt ttcattgctc accgcttgac
    11341 tattgctgag cggacagaga aggtagttgt cttggatcag ggcaagattg tcgaagaagg
    11401 aaagcatgct gatttgcttg cacagggtgg cttttacgcc catttagtca atagctagaa
    11461 agaggagagg atgaaaccag aatttttaga aagtgcggag ttttataatc gtcgttacca
    11521 taatttttcc agtagtgtga ttgtacccat ggcccttctg ctcgtgtttt tacttggctt
    11581 tgcaactgtt gcagagaagg agatgagttt gtccactaga gctactgtcg aacctagtcg
    11641 tatccttgca aatatccagt caactagcaa caatcgtatt cttgtcaatc atttggaaga
    11701 aaataagctg gttaagaagg gggatctttt ggttcaatac caagaagggg cagagggtgt
    11761 ccaagcggag tcctatgcca gtcagttgga catgctaaag gatcaaaaaa agcaattgga
    11821 gtatctgcaa aagagcctgc aaggagggga gaaccacttt ccagaggagg ataagtttgg
    11881 ctaccaagcc acctttcgcg actacatcag tcaagcaggc agtcttaggg ctagtacatc
    11941 gcaacaaaat gagaccatcg cgtcccagaa tgcagcagct agccaaaccc aagccgaaat
    12001 cggcaacctc atcagtcaaa cagaggctaa aattcgcgat taccagacag ctaagtcagc
    12061 tattgaaaca ggtgcttcct tggccggtca gaatctagcc tactctcttt accagtccta
    12121 caagtctcag ggtgaggaaa atccccaaac taaggttcag gcagttgcac aggttgaagc
    12181 acagatttct cagttagaat ctagtcttgc tacttaccgt gtccagtatg caggttcagg
    12241 tacccagcaa gcctatgcgt cagggttaag cagtcaattg gaatccctta aatcccaaca
    12301 cttggcaaag gttggtcagg aattgaccct tctagcccag aaaatcttgg aggcagagtc
    12361 aggtaagaag gtacagggaa atcttttaga caaggggaaa attacggcga gtgaggatgg
    12421 ggtgcttcat cttaatcctg agaccagtga ttctagcatg gttgcagaag gtaccctact
    12481 agcccaactt tatccatctt tggaaagaga agggaaagcc aaactcacag cttatctaag
    12541 ttcaaaagat gtagcaagaa tcaaggtcgg tgattctgtt cgctatacta cgactcatga
    12601 tgccgggaat caacttttcc tagattctac tattacaagt attgatgcga cagctactaa
    12661 gactgagaaa gggaatttct ttaaaatcga ggcggagact aatctaactt cggagcaggc
    12721 tgaaaaactt aggtacgggg tggaaggccg cttgcagatg attacgggca agaaaagtta
    12781 cctacgttat tatttagatc aatttttgaa caaagagtaa tgttcgtgtt tttagagtta
    12841 aataattttt aaactgtgag aaagattctt cttgcagttt tttctttaca atttttgaaa
    12901 aacatctgcc atttattcgg ttaaattctt gtgttttttg gttttttgtg gtaaaatgtg
    12961 ctcaagtaat acgaaaggcg aactttaaaa tgtcaaaaca attgatctat tcgggaaaag
    13021 ctaaagatat ctatacaact gaggatgaaa atcttattat ttcaacttac aaggaccagg
    13081 cgactgcttt caacggtgtc aagaaggagc aggttgcagg taagggagtc ttgaataatc
    13141 agatctcatc ttttattttt gagaaattaa atgcggctgg tgtggcgact cactttgtgg
    13201 agaaactttc agacacggaa caactcaata aaaaagttaa gattattcct ttggaagtcg
    13261 tgctccgcaa ctatactgct ggttcctttt caaaacgttt tggtgtggat gagggaatcg
    13321 ccttggagac tccgattgtc gaattttact acaaaaatga tgatttggat gatccattta
    13381 tcaatgatga acatgtgaaa ttcctacaga ttgcggatga ccagcagatt gcctacttga
    13441 aggaagaaac gcgtcgtatc aatgaactat tgaaagtctg gtttgctgag attgggctta
    13501 aattgattga ctttaagcta gagttcggtt ttgataagga tggcaagatt atcttggcag
    13561 acgaattttc accagataac tgccgcttgt gggatgctga tggcaaccac atggataagg
    13621 atgttttccg tagaggattg ggagaactaa ccgacgttta tgagattgtt tgggaaaagt
    13681 tgcaggaatt gaaataatct gtttgcaatg gaaaaccttc gtctctcaac taaaaggact
    13741 caggctgaaa aggtccccca gaccttttca ctctgtagag aactaggtga actaaccgat
    13801 gtttacgaaa ttgtctggga aaagttgcag ggtttaaaat aacaacctca aggctgttta
    13861 ggaatattgc aagagctgaa ataaaggaat aagaattgat ggataaacgt atttttgttg
    13921 aaaaaaaggc tgattttcag gttaagtcag agagtttggt tagagagttc cagcacaact
    13981 tgggactgtc aagcttgaaa agtattcgta ttgtgcaagt atatgatgta tttgacttgg
    14041 ctgaggactt gtttgcacct gcagagaagc acattttctc tgagcaggta accgaccatg
    14101 ttttagatga agtatctgtg caggcggatc ttgctaacta tgctttcttt gccattgaaa
    14161 gtctgccagg gcagtttgac cagtgtgcag cttcgtcaca ggaagccttg cttttgttgg
    14221 gaagttcgag tgacgtgaca gtcaacacag cccaacttta cttggtgaat aaagatattg
    14281 atgcgactga gttggaagct gtcaaaaact acctgctcaa tccagttgat tctcgtttca
    14341 aggatatcac gacagggatt gccaagcagg agttttcaga gtcagacaag atcattccaa
    14401 aattgacttt ctttgaaagc tatacagcag aagactttgc tcgctacaag gccgaacaag
    14461 ggatggccat ggaagtggat gatttgctct ttatccaaga ctactttaag tcaatcgggc
    14521 gcgtgccaac tgagactgaa ctcaaggttt tggacactta ctggtctgac cactgccgtc
    14581 atacgacttt tgagacagag ttgaaacaca tcgacttttc agcttctaaa tttcaaaagc
    14641 aattgcagtc aacctatgac aagtatattg ccatgcgcga ggaattaggt cggtctgaaa
    14701 aaccacaaac cttgatggat atggcgacta ttttcggtcg ttatgagcgt gctaatggac
    14761 gattggatga tatggaagtc tctgacgaaa tcaatgcctg ctcagttgaa attgaagtgg
    14821 acgttgatgg tgtcaaggaa ccttggcttc tcatgtttaa aaacgaaacc cacaaccatc
    14881 caacagaaat tgagccattt ggtggagcgg ctacctgtat tggtggagct attcgtgatc
    14941 cgttgtcagg ccgttcctat gtttaccaag ccatgcgtat ttcaggtgct ggtgatatta
    15001 cagcaccgat ttcggaaact cgcgctggga aattgccaca acaagtcatt tctaaaacag
    15061 cagctcatgg ttattcttca tatggtaacc agattgggct tgcaacaacc tacgttcgtg
    15121 aatacttcca cccaggcttt gtagctaaac gtatggaact tggtgccgtt gttggtgcgg
    15181 ctcccaaggg caatgttgtc cgtgaaaaac ctgaagcagg tgatgtgatc atccttctcg
    15241 gaggcaaaac aggtcgtgat ggtgtcggtg gtgcgacggg ctcttctaag gttcaaacag
    15301 ttgagtctgt agagactgct ggtgctgagg ttcaaaaagg aaatgccatc gaagaacgca
    15361 agattcagcg cctcttccgt aatggcaatg tcactcgtct gatcaagaag tccaatgact
    15421 ttggggcagg cggtgtctgt gtggctatcg gtgaattggc agacggtctt gaaatcgacc
    15481 tcaacaaggt gcctcttaaa taccagggct tgaatggtac agaaattgcc atctctgaat
    15541 cacaagaacg gatggcggtc gtggttcgtc ctgaagatgt ggataccttc gttgccgaat
    15601 gtaacaaaga aaatattgat gctgttgtgg tggcgacagt aactgaaaaa ccaaatcttg
    15661 tcatgcactg gaatggtgag acaatcgttg acttggagcg tcgtttcctt gacaccaatg
    15721 gtgtgcgcgt ggttgtcgat gccaaagttg tggacaagga tgtcaaactc ccagaagagc
    15781 gtcaaacatc tgctgaaaca ctggaatcag atacccttac ggttctatct gacctcaacc
    15841 atgcaagtca aaaaggatta cagactatct ttgactgctc tgttggacgc tcaacggtta
    15901 atcacccact tggtggtcgt taccaactca caccaactga ggcatctgtg cagaaattgc
    15961 cagttcaaca cggtgtgact catactgcgt cggtcattgc tcaaggtttc aacccatatg
    16021 tagctgaatg gtctccatac cacggtgctg cttatgcggt tatcgaagta actgctcgtt
    16081 tggtggctgc tggtgccaac tggtccaagg ctcgtttctc ttaccaagag tatttcgagc
    16141 gtatggataa acaagcagag cgtttcggtc agccagtagc tgctcttcta ggttctattg
    16201 aagcacaaat tcagcttggc ttgccatcta tcggtggtaa ggactccatg tctggtacct
    16261 ttgaagaatt gaccgttccg ccaaccttgg ttgcctttgg ggtgacgacg gcagatagcc
    16321 gtaaggtgct ctctccagaa tttaaagctg ttggggaaaa tatctactac atcccaggtc
    16381 aagccctctc tgcagagatt gattttgact tgattaagaa aaattttgct cagtttgaag
    16441 ccatccaagc tgaccataaa gtgacatctg catcagctgt caaatacggt ggtgtagttg
    16501 aaagtttggc tcttgctacc tttggaaact atattggtgc agaggtgacc ttgcctgaac
    16561 ttaaaacagc tttgacagct caattaggcg gctttgtctt cacatctcct gaagaaattg
    16621 ctggagtaga gaaggttgga caaacgaaag cagactttac actgactgtc aacggtgtga
    16681 agctagatgg acacaagctt gacagtgcat ttcaagggac attggaagaa gtttacccaa
    16741 cagaatttac ccaagcgaaa gaactagaag aagtaccagc tgtggcatca gatgttgtga
    16801 ttaaagccaa agaaaaggtt gaaaaacctg tggtttacat cccagtcttt ccaggaacca
    16861 actcagaata tgattcagct aaggccttcg aaaaagaagg tgcagaggtc aatttggtgc
    16921 cattcgtgac cttgaatgaa gaagctattg tcaagtcagt tgaaactatg gttgacaata
    16981 tcgacaagac taatattctc ttctttgctg gtggattctc ggctgcggat gaaccagatg
    17041 gttcagctaa gtttatcgtc aatatcctgc ttaatgaaaa agtgcgtgtg gctattgata
    17101 gctttatcgc ccgtggtggt ttgattatcg gtatttgtaa tggattccaa gccttagtca
    17161 aatcgggtct cctaccatac ggaaactttg aagctgctaa cagtactagc ccaaccctct
    17221 tctacaatga tgccaaccaa cacgtggcca agatggtgga aactcgcatt gccaatacca
    17281 actcaccatg gttggctggt gtgcaagtgg gcgatatcca cgctattcct gtttcgcacg
    17341 gtgaagggaa gtttgtcgtg acggctgagg aatttgcaga gctccgtgac aatggacaaa
    17401 ttttcagcca atacgttgac tttaacggta aaccaagtat ggattctaag tacaatccga
    17461 atggttctgt ccatgccatc gaaggaatta ccagcaagaa tggtcaaatc atcggtaaga
    17521 tgggccactc agaacgttat gaggatggtc ttttccaaaa tatcccaggc aataaagacc
    17581 aacacctgtt cgcatcagcg gttaaacatt tcactggaaa ataagactta cagattttct
    17641 aatagatagt atcagtaatg taaaagtcat gtaaatctag ctcttgatga ttacaaatga
    17701 aaattaggta taaaaaatga catacgaagt aaaatctctt aatgaagaat gtggtgtttt
    17761 cggtatttgg ggacatccag atgctgctaa gttgacctat tttggactcc acagtcttca
    17821 acaccgtggt caggaggggg caggaatcct ctccaacgat caaggacaac tgaagcgcca
    17881 tcgtgacatg gggcttttat cagaagtttt cagaaatcca gctaatttgg ataaattgac
    17941 aggagctggt gcgattgggc atgtgcgtta tgcgactgct ggcgaagctt ctgtagataa
    18001 catccagccc ttcctcttcc gttttcacga tatgcagttt ggcttggctc ataatggaaa
    18061 tctgaccaat gcagcctctc tcaagaaaga actggaacaa agaggagcaa ttttcagcgc
    18121 gacttcggac tctgaaatct tggctcacct cattcgtcgc agtcataatc ctagcctgat
    18181 gggcaaaatc aaggaagcgc tcagccttgt caaaggtggt tttgcctata tcttgctgtt
    18241 tgaggacaag ttgattgcgg ctcttgaccc taatggcttt cgtccgcttt ctatcgggaa
    18301 aatggccaac ggagcggtgg ttgtttcctc tgaaacctgt gcttttgagg tcattggtgc
    18361 cgagtggatt cgtgatttga agccaggtga gattgtgatc attgatgacg agggcattca
    18421 gtatgacagc tatacagatg atacccagtt ggcgatttgt tctatggagt atatctactt
    18481 tgcccgccct gattctaata tccacggtgt caatgttcat acggcacgta agagaatggg
    18541 agcgcaattg gcgcgagaat ttaagcatga ggcagatatt gtagttggtg tgcccaattc
    18601 ttccctaagc gcggctatgg gatttgcgga agaatcaggc ttaccaaatg aaatgggtct
    18661 gatcaaaaac caatacaccc agcgaacttt tatccaaccg actcaagaat tgcgggagca
    18721 aggagtgcgg atgaaactgt ctgctgtttc gggtgttgtc aaaggcaaac gtgtggtcat
    18781 ggtggatgat tccattgtac gtggaacaac ctctcgtcgt atcgttcagc tcttgaaaga
    18841 agcgggtgcg actgaggttc acgttgccat tggaagtcct gcactagcgt atccatgttt
    18901 ctacgggatt gatatccaga cccgtcagga gctgattgca gccaatcata cggtcgaaga
    18961 aactcgccaa atcattggtg cggacagtct gacttatctt tcaattgata gcttgattga
    19021 gtcgattggt atcgaaacag atgcgccgaa cggtggtctc tgtgtcgctt actttgacgg
    19081 tgactaccca acgcctctct atgactacga agaagactat cgtagaagtt tggaagaaaa
    19141 gaccagtttt tacaagtagg cgacagattc tccattaaag aaaaggaaaa aacaaatgac
    19201 aaataaaaat gcatatgccc agtcgggtgt ggatgttgaa gcgggttatg aagttgttga
    19261 acggattaaa aagcacgtgg cccgtacgga gcgtgcaggt gtcatgggag ctcttggtgg
    19321 ctttggtggt atgtttgacc tttccaagac tggggttaaa gaacccgtct tgatttcagg
    19381 gactgacggt gtcggaacca agctcatgtt ggctatcaag tacgacaagc acgataccat
    19441 cgggcaggac tgtgtggcca tgtgtgtcaa cgacatcatt gctgcaggtg cggaacccct
    19501 ctattttctc gactacgtag cgacagggaa gaatgagcca gctaagctag aacaagtggt
    19561 tgctggtgtg gcagaaggtt gtgtgcaggc tggtgctgcc ctcatcggtg gggaaacggc
    19621 tgaaatgccg ggcatgtacg gcgaagacga ctatgacttg gctggttttg cggtcggtgt
    19681 ggctgaaaaa tctcaaatca ttgacggttc aaaggtggta gagggagacg ttcttctcgg
    19741 acttgcttca agtgggcttc actcaaatgg ttactctttg gttcgtcgtg tctttgcgga
    19801 ttacacaggt gaggaagtcc taccagaatt ggaaggcaag aaacttaagg aagttctact
    19861 tgagccgact cgtatctatg tcaaggctgt cttgccgctc atcaaagaag agttggtcaa
    19921 cggcattgcc cacatcacag gtggtggctt tatcgaaaat gtccctcgta tgtttgcaga
    19981 tgacctagct gctgaaattg atgaaagcaa agttccagtg cttccaattt tcaaagccct
    20041 tgaaaaatat ggtcagatta aacacgaaga aatgtttgaa atcttcaata tgggtgtggg
    20101 acttatgttg gcggtcagcc ctgaaaatgt agagcgtgta aaagaattgt tggatgaagc
    20161 agtctatgaa attggtcgca tcgtcaagaa agaaaacgaa agtgtcatta tcaaatgaaa
    20221 aaaatagcgg tttttgcctc tggtaatggc tcaaattttc aggtgattgc cgaagaattt
    20281 ccagtggagt ttgtcttttc agaccatcgt gatgcctatg tgcttgagcg tgcaaagcag
    20341 ctcggcgttc tgtcctatgc ttttgaactc aaggagtttg agagcaaggc agactacgaa
    20401 gcagcccttg tcgaactctt ggaagaacac cagattgact tggtttgcct agcaggctac
    20461 atgaaaatcg ttggaccaac cttattgtcg gcttatgaag gtcggattgt caacattcat
    20521 ccagcctact tgccagaatt tccaggagct catgggattg aggatgcttg gaatgctggc
    20581 gtgggtcagt ctggtgtgac cattcactgg gtggattcgg gtgtggatac aggccaggtc
    20641 atcaaacagg ttcgtgtgcc acgactagct gatgatacca ttgacagatt tgaagctcgc
    20701 atccatgaag cagagtacag gttgtatccg gaagtagtga aggctctatt tacagattga
    20761 ctttttgatg attcatatga tatctttgat tttaaattgg agtcagtgtt tgttgaagac
    20821 ggcttcaaac ggaggtattt gtaatgttag aatctaaaaa aacaactcga tatgtatttt
    20881 atgtctatct gatgttatta acttggggaa tcttatttaa gtttgaaaca aatcctgaat
    20941 ttatagcatt tttcttagct ccaaggtata tcaattggat tccattttca gaaccactaa
    21001 tagtcgatgg aaaaattgtt tttgctgaaa tattatttaa tctgatttcc tttattccat
    21061 taggtgtttg tttccctttg ataaaaacta atttatctag tttaagaata gtcgggacag
    21121 gtttcttgat tagtttattg tttgagtgct tacagtatat tttagcaata ggtataacag
    21181 atataacgga tttgacttta aatacgctag gtgtctgtgt aggcttactg atttatcaaa
    21241 tttttataag agtgttcaaa tcacagacta gaaaatggat caatatctta ggtatgctta
    21301 gccttggttt tgcttatctt gttttactgt tactgcattt aattggtgtt taactaatga
    21361 ttaaaaagga gaatataatg actaaacgcg tcttaatcag cgtctcagac aaagcgggca
    21421 ttgttgaatt tgcccaagaa ctcaaaaaac ttggttggga gattatctca acaggtggaa
    21481 ctaaggttgc ccttgataat gctggggtgg ataccattgc tatcgatgat gtgactggtt
    21541 tcccagaaat gatggacggt cgtgtgaaga ccctccaccc aaatatccac ggagggcttc
    21601 tcgctcgtcg tgacttggat agccacttgg aagcggctaa ggacaacaag attgagctca
    21661 ttgaccttgt ggtggtcaac ctttacccat ttaaggaaac tatccttaaa ccagatgtga
    21721 cttatgctga tgcagttgaa aatatcgata ttggtgggcc gtctatgctt cgttcagcag
    21781 cgaaaaatca tgccagtgtt acagttgtgg tagatcctgc tgactacgct gtggttttgg
    21841 acgaattggc agcaaacggc gaaacctctt atgaaactcg ccaacgttta gcagccaaag
    21901 tatttcgtca cacagcggct tatgacgcct tgattgcaga atacttcaca gctcaagtgg
    21961 gtgaaagcaa gcctgaaaaa ctcactttga cttatgacct caagcaacca atgcgttacg
    22021 gtgagaatcc tcaacaagac gcggactttt accagaaagc tttgcctaca gattactcta
    22081 ttgcttcagc caaacagctc aacgggaaag aattgtcatt taataatatc cgtgatgcag
    22141 atgctgctat ccgtatcatc cgtgacttca aagatagtcc aaccgttgtg gctctcaaac
    22201 acatgaatcc atgtggaatt ggtcaagctg atgacatcga gactgcttgg gactacgctt
    22261 atgagtctga cccagtatct atctttggtg ggattgtcgt cctcaaccgt gaggtggatg
    22321 ctgcgacagc tgagaagatg cacggcgttt tcctcgaaat catcattgca ccaagctata
    22381 cggatgaagc gctagccatt ttgatcaata aaaagaaaaa cttgcgtatc cttgccttgc
    22441 catttaatgc tcaagaggct agcgaagtgg aagcagaata cacaggtgta gtcggtggac
    22501 ttctcgtgca aaatcaagac gtggtcaagg aaagcccagc tgactggcaa gtggtgacta
    22561 aacgtcagcc aactgagaca gaagcgactg ctcttgagtt cgcttggaag gctatcaagt
    22621 acgtcaaatc aaatggtatt atcgtgacca acgaccacat gacacttggt gttggtccag
    22681 gtcaaaccaa ccgtgtggct tctgttcgcc ttgccattga ccaagccaaa gatcgtctgg
    22741 acggggcggt ccttgcttca gatgccttct tcccatttgc ggataacgtg gaagaaatcg
    22801 ccaaagcagg aattaaggcc atcatccagc ccggtggctc tgtccgtgac caagaatcca
    22861 tcgaagcagc ggataaatac ggcttgacta tggtctttac aggtgtgaga cattttagac
    22921 attaagaaga taaaagggaa gaaaacagtt tctttccttt tttggcttaa aatgctaact
    22981 gaaacaagat taaaacgaac ttttttgata taatgttggt aaataattcg caaaagaggt
    23041 tgaggaatga aactgcttgt tgtcggttct ggtggtcgtg agcatgcgat tgctaaaaag
    23101 ttacttgaat caaaagacgt ggaaaaagtc tttgtagctc ctgggaatga tgggatgact
    23161 ctggatggtt tggaattggt aaatatctct atttccgaac attctaaatt gattgacttc
    23221 gcaaagacca atgatgttgc ttggaccttt atcggtccag atgatgccct tgctgctggc
    23281 atcgtggatg attttaacca agctggactt aaggcctttg gtccgactag ggctgcagcg
    23341 gagctggagt ggtccaagga tttcgccaag gaaatcatgg tcaaatacgg cgttccgaca
    23401 gcaatatatg gcacattttc agatttcgag gaagccaagg cctatatcga aaagcatggt
    23461 gcgcctatcg tagtcaaggc ggatggcttg gcacttggga agggtgtcgt cgttgctgag
    23521 acggttgagc aagcggtcga agccgctcat gagatgcttt tggacaataa atttggtgac
    23581 tcaggtgcgc gcgtggttat tgaggaattc cttgaaggag aggaattttc actctttgcc
    23641 tttgtcaatg gtgataagtt ctacatcatg ccaacggctc aggaccacaa acgtgcctat
    23701 gatggcgaca aagggcctaa cacgggtggt atgggtgcct atgcgccagt tccacactta
    23761 ccacagagtg tagttgatac agcggttgac accattgtca agccagttct agaaggggtg
    23821 attaaagaag gtcgtcctta tctgggagtt ctttacgcag ggcttatcct gacagctgat
    23881 ggaccgaaag tcattgagtt caacgctcgg ttcggagatc cagaaactca gattatcttg
    23941 cctcgcttga cctctgactt tgctcaaaat atcacagata tcctggatag caaggagcca
    24001 aatatcatgt ggacggacaa gggtgtgact ctgggtgtgg ttgtcgcatc caagggctac
    24061 ccgctagact atgaaagggg cgttgagttg ccagccaaga cagaaggcga tgtcatcacc
    24121 tactatgcag gggctaagtt tgcggaaaat agcagagcac tgctctcaaa cggcggacga
    24181 gtttatatgc tcgttaccac agcagatacc gtcaaagaag cccaagccag catctaccaa
    24241 gaactatccc aacaaaaaat agaaggactc ttctaccgaa cagatatcgg aagcaaggca
    24301 attaagtaaa gatataagaa taacgcgccg tagtcgccaa acacgataat ggtcgtcgtg
    24361 gtgaaaagac cagaacagtg aatgttctgg tcagggggaa acttggagac cgtaggctca
    24421 aagtttagga atgaaaccga aggtttgctt ccgcctccat cacctaagac cattatcaaa
    24481 aagaaaaata aaaattcaca aaatacgtta atggtcgtat ggtttgcgag cgttagcgag
    24541 ctaatataga ataatcaccg ccgttgtgaa agaacgattg gatgacaatc caatcgttca
    24601 gggaaattgg aagaccttgg gtttccaatt taggcatgag acacctttgg tggctgctgc
    24661 cgtccctcac aagctaaggt gattgttgaa aaagaggaaa aaggagaaga aatgaaacca
    24721 gtaatttcca tcatcatggg ctcaaaatcc gactgggcaa ccatgcaaaa aacagcagaa
    24781 gtcctagacc gcttcggtgt agcctacgaa aagaaagttg tttccgcaca ccgtacacca
    24841 gacctcatgt tcaaacatgc agaagaagcc cgtagtcgtg gcatcaagat catcatcgca
    24901 ggtgctggtg gcgcagcgca tttgccaggc atggtagctg ccaaaacaac ccttccagtc
    24961 attggtgtgc cagtcaagtc tcgtgctctt agtggagtgg attcactcta ttctatcgtt
    25021 cagatgccgg gtggggtgcc tgttgcgacc atggctatcg gtgaagctgg agcgactaac
    25081 gcagctctct ttgccctccg tctcctctct gtagaagata agtccattgc ggatgcactt
    25141 gccaactttg ctgaagaaca aggaaaaatc gcagaggagt cgtcaaatga gctcatctaa
    25201 aacaatcgga attatcggtg gcggtcaact gggtcagatg atggccattt ctgctatcta
    25261 catgggccac aaggttatcg cgctggatcc tgcggcggat tgcccggcct ctcgcgtggc
    25321 ggaaatcatt gtggcacctt ataacgatgt ggacgccctc cgtcagttgg cagaccgttg
    25381 cgatgtcctc acttatgagt ttgaaaatgt cgacgctgac ggtttggatg ccgttatcaa
    25441 ggatggacaa ctccctcaag gaacagatct gctccgcatt tcgcaaaatc gtatttttga
    25501 aaaggacttt ttgtcaaaca aggctcaagt cactgtggca ccctacaagg tcgtgacttc
    25561 tagcctagac ttggcagata tcgacttgtc gaaaaactat gtcctcaaga ctgcgactgg
    25621 tggctacgat ggtcatggac aaaaggttat tcgttcagaa gcagacttgg aagcagccta
    25681 tgcgctagca gactcagcag actgcgtctt ggaagaattt gtcaactttg accttgagat
    25741 ttctgtcatc gtgtcaggaa atggcaagga ggtgacgttt ttcccagttc aggaaaatat
    25801 ccaccgcaac aatatcctgt ctaagaccat cgtaccagcc cgcatttctg aaagtctagt
    25861 agacaaggct aaagctatgg cagtgcgaat cgcagaacaa ctcaacttgt ctggaactct
    25921 ctgtgtggaa atgtttgcga ctgatgatga cgttattgtc aatgaaatcg ccccacgacc
    25981 acataactct gggcactatt ctattgaagc ctgtgatttc tctcagtttg acacccatat
    26041 tctcggtgtt ctcggagcac cattaccagt catcaaactc catgcgccag ccgttatgct
    26101 taatgtcctc ggtcagcatg tcgaggctgc tgagcaatat gtgacagaaa attcaagcgc
    26161 ccacctccac atgtatggta aaatagaagc gaagcacaac cgcaagatgg gacatgtgac
    26221 cttgtttagt gatgtaccgg atagtgtgga tgagcttggg gaagggattg atttttagga
    26281 caagtctatg atacaaatta tcgttaatac atttattgaa aaggatagga ctggagcagt
    26341 tgttgaagtg ttgtatgcca gtgctgacca agataaggta caagctaaat atgaagaact
    26401 agctgcacaa taccccgaaa attatttagc tatctatgat gtaccgctgg atacggattt
    26461 gaatacacta gatcattacc cgtctgtgtt tattgaaaaa gaggagtttg agtagaaatc
    26521 ttggtttacc tagatagctt attcccaaca gcttaagaag aaaggaaaaa ttaacacatg
    26581 atcaaccgtt actctcgccc tgagatggcg aatatttgga gtgaagaaaa taaataccgt
    26641 gcttggcttg aggtggaaat cctctctgac gaggcatggg ctgagttggg ggaaatccct
    26701 aaggaagatg tggctttgat tcgcaagaag gcggactttg acatcgaccg tattttggaa
    26761 attgagcagg agacgcgcca cgatgtggtg gctttcacgc gtgcggtttc tgagactctt
    26821 ggtgaagagc gcaagtgggt tcactatggg ttaacttcta ccgacgtggt ggatactgcc
    26881 tatggttacc tctacaagca ggccaacgac atcatccgtc gtgaccttga aaacttcact
    26941 aatatcatcg ctgacaaggc caaggagcac aagttcacca tcatgatggg gcgtactcat
    27001 ggtgtgcacg ctgagccgac aacttttggt cttaaattgg caacttggta tagcgaaatg
    27061 aaacgcaata tcgagcgctt cgagcatgcg gctgctggtg tagaagctgg taagatttct
    27121 ggtgcggttg ggaactttgc caatatccca ccatttgtag aggagtatgt ctgcgataaa
    27181 cttggcatcc gtgcccaaga aatctctaca caagtccttc ctcgtgacct tcacgctgag
    27241 tactttgcgg ttcttgccag cattgcgact tcaatcgaac gtatggcgac tgagattcgt
    27301 ggtctacaaa aatctgagca acgcgaagta gaagagttct ttgctaaagg gcaaaaaggg
    27361 tcttcagcaa tgcctcacaa acgcaaccca atcggttctg aaaatatgac tggtctggcg
    27421 cgtgtcattc gtggtcacat gattacggct tatgaaaacg tcgctctctg gcacgaacgc
    27481 gatatttctc actcatcagc tgagcgtatc atcacaccag atacgaccat tttgattgac
    27541 tacatgctca accgttttgg aaatatcgtc aagaacttga cagtcttccc agaaaatatg
    27601 atccgaaaca tgaactcgac ttttggtctt atctttagcc aacgggctat gttgacattg
    27661 attgaaaaag gcatgacccg tgagcaagcc tatgacttgg tgcaaccaaa aacagcctac
    27721 tcttgggaca accaagtaga ctttaaacta cttcttgagg cagattcaga agtaacatca
    27781 cgtctcacac aagaagaaat cgatgaaatc ttcaacccag tttattacac caaacgagtg
    27841 gatgatatct ttgaacgtct tggactaggt gattaattaa aaaataaaca gcgagcttca
    27901 atctcgctgt ttatttttta tcgaaaagac ttagtcttct tttcttttag tgagtccata
    27961 ggctgctagt gtggacatga gtcctgcgac tactagtcct gcagaatcgt gagttcctgt
    28021 ttcaggaagt tttttctctg ttaccacagg agctggatct tgaggaagag ctttgctttc
    28081 ctcagcggga gcagttgatg gagctggttg gcttgggatt tctagttttg gtttttcttc
    28141 agcaatagcg gcttgtccgt tttcatcgcc tacatgtgtt accatagttc cgacttcgac
    28201 tatttgagta acggcttcct gtgctacgac actatttaca agtgttttca cttccttacc
    28261 atcggcagaa gtgctcacag agtagaagtt gctacgatgt ccattgacgc ccttagtaat
    28321 gacttgtgtt tttcctttga gtaagagtgg attttcacga gtcactgtgg taaatggaat
    28381 ttcttctttt tggatatcca gtctaggttt tacctcagta gttggtgcaa gaccactttc
    28441 atcacccttg tgagttacag gagcgccaac ttcaaccact tggtttataa cttctttggt
    28501 tacctggcta tcaaggactg tttctgttgt ttttccattt tcagtgagta cagagatgta
    28561 atgagttcgt tcacctttga ctcctgctgt gataatattt tcctgaccag ctgggaggtt
    28621 aggattttct ttcttgataa cttcaaatgg aatttcttca gttcttgtga tgagttctgg
    28681 tctggtttca acattggcag ccacttcatt ttcatccagg cttcctgaat gagttgcagc
    28741 tggtttgagg ccttgaagag cggcttttag gttggctaca agtgtgtcaa gctcagcttg
    28801 tttattacgg ttgaggttgt aatttagagc tgttttagct gcgtcaaggg cctcaagact
    28861 ttctttacta tatccttcta agtttgtagg aattttagct aattcttcgc ggagagcatt
    28921 ataattagca cggaagtagt ctttgttgtg gtctgcaaag gcagtcatga gttcaaagat
    28981 ttcctcttcc ttgtattcag cgcttggtct atctgcccag attgaaagca tacttccgac
    29041 tgttggaaga tctacttcag gatatttggt agaagctagt tgattgaatg gtgtttttcc
    29101 agtattctca atagctttct tgaggaaacc accaccatct tctggttttt gaccaagaat
    29161 gtagtaccag tcaccgttgg tattcaagaa tttatagcct ttgcttgcta ggtattgagg
    29221 tgatgcgagg ttatatcccc accagccttt agaccagtaa gaaatcaaga catctttgtc
    29281 aaactgaaca tcgtccttgt cttcatagta gaagccatcg ttgaaggcca ttggttgaag
    29341 ccctctttct ttggccatag ctgcgagggt gttggcatat tcggcaaatt tgccatagag
    29401 ttgataccac ttgaggtagt accagccttg ggcactagtc gcatcgttgg cgtattcgtc
    29461 agtaccaaag ttgaaaatct ttgttttacc tgcaaagaag tccatgtatt taccgatgag
    29521 ggcttttaca aagttcatcg cttcttcgtt tttcaagtcc atagttgttt ttgaaacttt
    29581 atcaaagtgg gcttgaggat ttttaatacc taatttttcc atggcaacca gcatagcatc
    29641 catgtgacct ggactgttaa tagctgggat gagaccgatg tccttagatt tagcgtattc
    29701 aattagctct gtcacttctg cctgtgttag tgcagtaccg tttggatcgt cgtagtaagc
    29761 tttagttcct tcgataatag cttttttaac gtcatcacta gcataggttt ttccgttggc
    29821 agtaatggtc atatcatcga gtagaaagcg aagtccgtca tttcctagaa ggagatggac
    29881 atcagaatat ccgagctcac tggccttgtc tacgatgcgt ttgagctggt ccagagtaaa
    29941 gtatttgcgt ccagcatcga ttgagattac cttgtttttg gcaagttttt caacctcacg
    30001 tttagcttct tcttcttttt gagcttcagg cgtgagggtc aagttgttga cagtttcttg
    30061 aagtttagca atggcttgat caatcgtatc ttgttgggca cggctaaggt tgctatcgag
    30121 agagcgaata gctttttcag cttcttttac ggccgcgacg ctttctgcag tataacggtt
    30181 caggtctttt ggtaccttgt taagtgcttg ctctgcagat tcataatcag ctgcaaagta
    30241 ttcagcgttg gcatttgcaa aatgacgcat gagtttgaag aggtgtgatg gtgaataacg
    30301 tgcagatgga gtgtcagccc aagcagctac cataccaccg atgattggga tatcagctcc
    30361 ttctgttttt ggtacagaag tgattggtgt gtttttaata ccatttagcc cctgatcgag
    30421 attgtaccag ccttggccat cagcgtttcg tccaagaacg tagtaccaag catcattggt
    30481 attaaggatt tggtgacctt tttcagctag tagtttagaa gaagcgacat cgtagcctcc
    30541 ccaaccacca gtccacatag aaacgatgat gtctttgtca aaactaccaa agcttgtgtc
    30601 gctattgtag tagataccgt cgttaaaggc cattggtttg agaccgtgcg attttacaat
    30661 acgagcgagg tcattggcgt aggcaataaa tttttcatag ccttttacag ggtagccttc
    30721 gtttggatag tatttatcag cttgaagcac actccaacct ttagcatctg tcgcatcatt
    30781 ggcatattca tcaagtccga tgttgaagat ttcagtcttt ttcgcgaaat aagcagcata
    30841 cttgtcgata agggcttttg taaaagcgac agcttgttcg ttgtcaagat cgacagtacg
    30901 ggctgattcc ttcccaaaat agctaaagtt agggttttgg attcccaatt ctttcatggc
    30961 attgagaatc gcatccatgt gaccaggact atttactgtc ggaatgagac cgataccttt
    31021 atctttggca tagttaatca gatctgtcat ttgactttct gttaagtgat tgccgtttgg
    31081 atcgttgtaa taatcatttg tacctttttc aatggcgcgt ttgacatcgt cactgtcata
    31141 ggtcttgccg ttagctgtga tgctcatatc gtccaacatg aaacggagtc catcatttcc
    31201 gactaatagg tgtaaatcag tgtagccata atgtttcgct ttatcgatga tttccttgag
    31261 ctgttctggt gagaaatatt tacgtccagc atcaatagaa acaattttct ttttcgctag
    31321 tttttcattt acagttgcag cacgttcctt tcctgtctct gtttccggtt tgtcagcctc
    31381 tgctttcgct tcatcttttt tagctggttt atccttgtca gtcttgtctg tatttgactc
    31441 tttagaatca acctctttcg cttcttcctt tttagggcta gcttcttctt cctttttatt
    31501 agcagtttct ttttcagcag aagttggagt taccacctct gctttatcac taggagttga
    31561 actaacttcc tcttgtggtt tttcttctgt ttttggaaga ctagctacct tatcagtagc
    31621 tggagtttct gtttctacag tttttggagc ttctggttga agctctgctt taggtgtttc
    31681 ctcagtccga ttttcggatg attgagggga atcagaaact gtatggatgg tcggttggtt
    31741 ttctgtagta gtagtagtaa ctccatcggc tgcaacagtc tgtgcttgga aggcaaatcc
    31801 aattagaaca gaagctgctc ctacagcgta tttacgaata gaaaaacgct gttgtttttc
    31861 atgtttcatt gcaaaacctc ctgattgcat tgttatattg atagcgatta tataaatcaa
    31921 cgcccttatt ttatttctta tattaacgag agtcaagagg agatgacaaa aaactataat
    31981 aagtataaaa aaatataaaa tttaaactta agatttcaga ttggtcggaa aaaatgcata
    32041 tatatatcta atataatttt tggttctatt tctataaaat attccacaaa ttatagaatc
    32101 ttccaaaaat aggtaagcgc tacctttttg gtgtggtata ataagcatag aaaaagcccg
    32161 agcgattagg ctcaggcttt cttcttagtg atcacggtca catgagatga atttaatctt
    32221 gtagtaatca gatcgtttgt aagtttcact gtattctaaa acttggccag ttgattcgag
    32281 tttggtgatt ttagtttgta ggacagtagg gaaatgttca tcgactccga ggactgaagc
    32341 cgcatgttct ggagttggaa agactatttc gttgatttct tcaaagtgtt catcattcat
    32401 gtgaatgtgg tagtctaact tgaaacgatt atagatagaa ctatagtatt caaggtttgg
    32461 ataatttgcg ttgatatatt gttctgggat gtaggatgta tggtagatat aaacgacacc
    32521 gtttgattcg cggatacgtt caatcttgta gtagaattga tcgccacgta gacccaattt
    32581 ttccaagtaa acaagcttgt ttccgcgttc aattgaaaga acagttacct tatcatcttt
    32641 agcattgaag agttcaatat ctgaaaactc tacaagcttg tgtttgcgtg cacgtgaaat
    32701 gaaagttcct tttccttgtt ggcggacaat atagccatct ttggcaaggt cgtttaaggc
    32761 gcgaacaact gtgatagagc tgacatcgta cattgaaatg agttctgctt cagtgtaaaa
    32821 tttatctcca ctgctaaact gcccagagat gattttattt tttaattcgt cttttatgta
    32881 ttgatatttg ggaattgcca tatttttacc tctattttcc ttctccatag aaaattttac
    32941 cataaaagcg aaaaaaatag tagtcttttg aataaaaaat tagaataata gtttgaaaaa
    33001 ttaagcgata tagggattgc tcatatttta taaatgcatt ctatacaaaa ttattttagg
    33061 tactatattc caaatttaaa gagcgtttga aatgggtcta aaaatgtttg aaactaattg
    33121 aatgtgtgta taatagtaaa aatgcagtaa atatcccgac aatttctatt gacaattcaa
    33181 acagattggt ttataattaa tataacaaca aatgaaagcg caaactttcg cggtcggaag
    33241 gtagttttat gacacgattt gagatacgag atgatttcta tctcgatgga aaatcattta
    33301 agattttatc tggtgccatt cattatttta gggttcctcc agaggattgg tatcattcgc
    33361 tctataactt gaaggctctt ggttttaata cggtagagac ttatgttgct tggaatttac
    33421 acgagcctcg tgaaggtgag tttcattttg aaggtgatct ggatttagag aaatttctcc
    33481 aaatagcgca ggatttgggt ctctacgcaa ttgtgcgtcc gtctccattt atctgtgcgg
    33541 aatgggaatt cggtggctta ccagcttggc tcttgaccaa gaacatgcga attcgctcat
    33601 ccgacccagc atatatcgag gcagttggtc gctactatga tcagttattg ccaagactgg
    33661 tgcctcgttt gttggacaat ggtggcaata ttctcatgat gcaggttgaa aatgagtatg
    33721 gttcttacgg agaagataag gcttatctga gagcgattcg acagctaatg gaagagtgtg
    33781 gcgtaacctg tcccctcttt acatcagatg gtccatggcg agctactctg aaagctggaa
    33841 ccttaattga agaggacctc tttgtaacag gaaactttgg ttctaaggca ccttacaatt
    33901 tttcgcagat gcaggaattc tttgatgaac atggtaagaa atggccactc atgtgtatgg
    33961 agttctggga tggttggttt aatcgttgga aagaaccgat tatcacacgg gatcctaagg
    34021 aattggcaga tgcagttcga gaagttttgg aacaaggctc catcaatctt tacatgttcc
    34081 acggtggtac aaactttggt ttcatgaatg gttgctcggc tcgaggaact ttggacctgc
    34141 cacaagttac gtcttatgat tacgatgccc ttctggatga agaaggaaat ccaactgcta
    34201 aatatcttgc agtcaagaag atgatggcaa cacatttttc agagtatccg cagttggaac
    34261 cactctacaa agagagtatg gagttggatg ctattccact agttgaaaaa gtttctttgt
    34321 ttgaaacctt agatagcttg tcaagtcctg tagaaagtct ctatcctcaa aagatggagg
    34381 agctgggaca aagttatggc tacctacttt atcgaacaga aacaaactgg gatgcagaag
    34441 aagaaagact tcgtatcatt gatggtcgag atagggccca gctgtatgtc gatggtcagt
    34501 gggttaaaac tcaatatcag acagagattg gggaagatat tttttatcaa ggtaaaaaga
    34561 aagggctatc taggttagat atcttgatag aaaatatggg gcgtgtcaac tatgggcata
    34621 agttcttagc ggatacgcaa cgtaagggaa ttcggacagg ggtctgtaag gatctgcatt
    34681 tcttactaaa ctggaaacac tatccactcc cactagacaa tcctgagaaa attgattttt
    34741 caaaaggatg gactcaagga caaccagcct tttacgctta tgactttaca gtcgaagagc
    34801 caaaagatac ttacctagac ttgtctgagt ttggtaaggg ggttgccttt gtcaatgggc
    34861 agaatctagg acgtttttgg aacgttggcc caactctctc actttatatc cctcatagct
    34921 atctcaagga aggtgccaac cgcatcatta tctttgaaac agaaggtcaa tataaagaag
    34981 agattcattt aactcgtaaa cctacactaa aacatataaa gggggaaaac ttatgacaat
    35041 tgtaggatgc cgtattgatg gacgtttgat ccacggacaa gtagccaatc tttgggctgg
    35101 aaaactaaat gtttcacgca ttatggttgt agacgacgaa gttgtcaaca acgatattga
    35161 aaagagtggt ttgaaacttg cgacaccacc aggtgtgaaa ttgagtattt tgccagttga
    35221 gaaagctgca gccaatattc ttgctggcaa atacgatagc caacgtctct ttatcgtggc
    35281 tcgtaaacca gaccgcttcc ttggtttggt agaagcaggt gtaccacttg aaactcttaa
    35341 tgttgggaat atgtctcaaa caccagaaac tcgttctatt acacgttcta tcaacgtagt
    35401 agacaaggat gtggaagact tccacaaact ggcagaaaaa ggtgttaaac ttactgctca
    35461 gatggttcca aatgatccaa tttcagactt tttgagctta ttaaaatagg aaaaaaattt
    35521 ttaggaggtc attgttatga tacaatggtg gcaaatttta cttctcactt tgtactcagc
    35581 ttatcaaatc tgtgatgagt tgacgatcgt ttcatctgca ggttcccctg tatttgctgg
    35641 tttcattact ggtttaatca tgggagatgt gactactggt ttacttatcg gtggtaactt
    35701 gcaactgttc gttcttgggg ttggtacctt cggtggtgct tctcgtatcg acgcaacttc
    35761 tggtgcggtt cttgcgacag ccttctctgt ttcacaagga attgatgcac cgcttgcaat
    35821 tactacaatc gctgtaccag tagcagctct cttgacttac ttcgacgttc ttggtcgtat
    35881 gactactacc ttcttcgctc accgtgtgga tgctgcaatc gaacgctttg actataaagg
    35941 tattgaacgc aactacttgc ttggtgcgat tccgtgggct ctatctcgtg cccttccagt
    36001 cttctttgcc cttgcttttg gtggtgcctt tgtacaatca gtagtagact tcgttgaagc
    36061 ctacaaatgg gttgcagatg gcttgacact tgcaggacgt atgcttccag gtcttggatt
    36121 tgcaatcttg cttcgttacc ttccagttaa acgtaacctt cactaccttg ctatgggatt
    36181 tggtttgaca gctatgttga ctgttcttta ctcatatgta acaggtcttg gtggcgctgt
    36241 tgctggtatc gtaggtactc ttcctgctga agttgctgaa aaaattggtt tcgtgaacaa
    36301 cttcaaaggt ttgtctatga ttggtatttc tatcgtaggt attttccttg cagtgcttca
    36361 cttcaaaaat agccaaaaag tagctgtagc agcaccttct acaccatcag aaagtgggga
    36421 aatcgaagat gacgaattct aattacaaac ttacaaaaga agattttaat caaatcaaca
    36481 aacgtagctt gtttactttc caattaggtt ggaactacga acgtatgcaa gcttctggtt
    36541 acctttacat gatcttgcct cagttgcgta aaatgtatgg tgatggaact cctgaattga
    36601 aagaaatgat gaaagttcat actcaattct tcaatacttc accattcttc cataccatta
    36661 tcgctggttt tgaccttgcc atggaagaaa aagatggtgt aggttcaaaa gacgctgtta
    36721 acggtatcaa gacaggtttg atgggaccat tcgctcctct tggggataca atctttggtt
    36781 cacttgtacc tgctatcatg gggtcagtcg cagcaactat ggctatcgct ggccaacctt
    36841 gggggatctt cctttggatt gcagttgcag tagcgtatga catcttccgt tggaaacagt
    36901 tggaatttgc ttacaaagaa ggggttaacc ttatcaacaa catgcaaagt accttgacag
    36961 ctttgattga cgctgcatct gtacttggtg tcttcatgat gggtgctctt gtagcaacag
    37021 tgattaactt tgaaatttct tacaagttgc caatcggtga aaagatgatt gatttccaag
    37081 acatcttgaa ccaaatcttc ccacgtttgc ttccagcaat ctttactgcc tttatcttct
    37141 ggttgcttgg taaaaaaggt atgaactcta ctaaagctat cggtattatt atcgtacttg
    37201 ctttggctct ttctgccctt ggtcactttg cacttggaat gtaattcctt atgactaaat
    37261 cattaatttt ggtgagccat ggtcgcttct gtgaggagct tagaggtagc acagaaatga
    37321 ttatgggccc acaagacaac atttacacag tagctcttct tccagaagat ggcccagaag
    37381 aatttactgc taaatttgaa gctgttattg aagggttgga tgatttccta gtctttgcgg
    37441 atcttctcgg tgggacacct tgtaatgtgg tgagtcgctt gatcatggaa ggtcgtgata
    37501 ttgaccttta cgcagggatg aatcttccaa tggtgattga atttatcaat gcgagcctta
    37561 caggcgcaga tgcggactac aagagccgtg ctgcagaaag cattgtgaaa gttaatgacc
    37621 tgttagcggg cttcgatgat gacgaagatg aataatactc ttcgaaaatc tcttcaaact
    37681 acgtcaacgt cgccttaccg taggtatatg ttactgactt cgtcagtctt atccggcaac
    37741 ctcaaaacgg tgttttgagc tgacttcgtc agtcttatcc ggcaacctca aagcagtgct
    37801 ttgagcagcc tgcggctagt ttcctacaga ttttagttgg aactcgattc aattcatgtg
    37861 acaacgtgaa aatcgttaga gcattttata tagaatatac atgggaatgg agcttactcc
    37921 cattcctata tttaatagaa aaagaggaac tcaatgctac attatacaaa agaagacttg
    37981 ctcgaattgg gtgcagaaat cactacgcgt gaaatctacc aacagcctga tgtatggaga
    38041 gaagcttttg aattttatca agcaaaacgt gaagaaattg cagccttcct acaagaaatc
    38101 gctgataaac atgactatat taaggttatc ttgacaggtg ctgggacttc tgcttatgtg
    38161 ggagacacct tgctacctta ttttaaggaa gtctatgacg aacgcaaatg gaatttcaat
    38221 gctattgcga caacagatat cgttgccaaa ccagcaacct atttgaaaaa agatgtggca
    38281 actgtccttg tgtcttttgc tcgtagtggg aactcgcctg aaagtgtggc gactgttgat
    38341 ttggccaaat ccttggtgga tgagctttat caagtgacga ttacttgtgc agcagatggt
    38401 aaattggctc ttcaagctca cggtgatgac cgtaatctct tgctcttgca accagctgtc
    38461 tctaatgatg ctggatttgc catgacttct agctttacgt ctatgatgtt gacagctctc
    38521 ttggtctttg atcctacaga atttgctgtt aagtctgaac gttttgaagt tgtatctagt
    38581 cttgcccgta aagttttaga caaggcagaa gatgtcaaag agctcgttga tttagacttt
    38641 aaccgtgtca tctatctagg cgctggtcct ttctttggac ttgctcatga agctcagctc
    38701 aagattttgg aattaactgc tggtcaagtt gcgaccatgt atgaaagccc agttggcttc
    38761 cgtcacggtc caaaatctct tatcaacgac aatacagttg ttttggtctt tggtacaagg
    38821 acagactaca ctcgtaagta cgacttggac ttggttcgtg aagttgctgg tgaccagatt
    38881 gctcgtcgtg ttgtgctttt gagtgatcaa gcttttggtc ttgaaaatgt caaagaagtg
    38941 gtccttggtt gtggcggtgt cttgaatgat atttaccgtg tcttccctta catcgtttat
    39001 gcccaactct ttgccctatt gacttcactc aaggtagaaa ataaaccaga tacaccgtct
    39061 cctacaggta cagtaaaccg tgtagtacaa ggtgtcataa ttcacgaata tcaaaagtaa
    39121 gacagtgttt atgaattctt gacaagagga tttgtaaatt atcagataaa ccatagattg
    39181 tcagtacgct ttctatggtt tgtttgcttg agagaaatag taaaaggaga acagaatgaa
    39241 agcatacaca gagcgtgtat ttggaaatgt tgagggcgag gatgtcttgg cctatcgatt
    39301 tgagacagac ggtggctacc aacttgaggt tatgacttat ggtgcgacca tcttgcgcta
    39361 tgtcgcacct gacaaggctg gaaattttgc caatgttatc ttgggatttg atgactttga
    39421 tagttatgta ggcaatagtc ccaagcatgg agcaagtgta ggtcctgtag cgggtcgtat
    39481 tgcaggtgcg acctttgagc tcaatggtaa gacctatgac cttgaggtta ataatgctag
    39541 caactgtaat cacagtggtt caactggttg ggattccagc ttgtttgaag ttgaagaagt
    39601 aagcgatcat ggcttgactc tctacacaga gcgtacagat gggacaggag ggttccctgg
    39661 aaatctcaag atttggatca gttatcactt ggaagaaact ggtgcctatg aaatcagcta
    39721 caaggtaacg accgatcagg atacgctggt caatccaacc aaccacagct atttcaactt
    39781 gtctggtgat ttcacgcaga cgattgaccg tcatgtcttc caactaaaca cagagggcat
    39841 ttactcaatc gctcctgacg gtgttcctgc caaaactcca gaagccaacc gtgatgtggt
    39901 caaacacatc tacaatggtg ccttgttgaa ggatatcttt gcagaagaag atgagcaaat
    39961 ccagctggca tcaggtttgg atcatccatt tgcccttcct gcaggtcatg acaatgctgg
    40021 attcctttat gaccaaaatt caggtcgctt cctgcttttc aagacagaag ctccttgctt
    40081 tgtggtctac acagcaaact ttgtggatga aagtgtcatc ataggaggtc agccaatgct
    40141 acagcacaat gggattgctc ttgaagcgca agctttacca gatgccattc acagtgacct
    40201 taaaggccaa gtcattctta aagctggtca aaccttcacc agtaagacac gttatgaact
    40261 tgttgtgaaa taaaaaagct ggtcaaaaag tctttaaatt aaaataatgc atattgtcag
    40321 gtgatgaaaa gtttgataat atgcgtttta ttatgaaatg atttacttta tcttatcctg
    40381 aaatggtgtt atttttgagt tatctggctt gactttcttg atggaaatta tataatagtt
    40441 gtaataacaa taattacaac gagaaaagag gaccatttat gacctatgaa tacaagagtc
    40501 acatttattt ggcagagaca gttttaaatg taaaggattt ggccagtcaa acagcctttt
    40561 atcagcaagt tatcggttta gaaatcttat ctcaaactga gacagagtcc attctaggcc
    40621 ttggtggaaa agtcttggta cagctgattc aagcacaaga gagcggagaa gtgagggaac
    40681 attatggtct ttaccatttg gccattctct tacccacacg caaggctttg gctgatgtct
    40741 tgaaacacct gacagattta cagattcctc ttgtcggcgg tgcagaccat ggttacagtg
    40801 aagctattta cttggaagat ttggagggaa atggcattga actctatcga gataagccag
    40861 tttccacatg ggatattcga gaagatggac gcattatcgg agtgacggag gctcttgcgg
    40921 cgcaggatat ttatgagttg ggggaaagag tagagccctt tatcctggca gaaggtacga
    40981 gaatggggca tattcatctt tccgtcaagg atagtcgaaa gtccagccag ttttatcaaa
    41041 aggtgttagg gctagagaat aaattcagtg tgcctggcgc tagttggatt gcggctggag
    41101 attaccatca tcatttagca gttaacgaat ggggaggaaa aggtctggct tcgcgtaagc
    41161 aaggcttacc aggtttagcc tactatgtca tcgaagtcgc acataaaaaa gaactgttaa
    41221 cgattgccca acgagcacaa gaagttgacg caccaatcaa atggatgaca tcgatccaat
    41281 tggaaatcac agactcagat ggcatcgtga cccgtattcg tttagcaagg taaaattagg
    41341 aatttttaat aagttataag tattgctagt ttgctttttg aacggtcttt ggtaacagaa
    41401 ctgcgtgagc tggatgggcg agaattttga caaagaagct gattagagat ataatgaaga
    41461 aaaatcgagc aaggaaaaag aaatgacaaa ttcaaagtat attacttgtt tgaaacgttc
    41521 agagggccag ttgtgtggga ttcaaaagat gattgaagga gatcgtgact gtgctgatat
    41581 tgtgacgcaa ctgacagcag tgagatctag tgtagagcgc gtgattgaga tgataattac
    41641 cgaaaatctt actgaatgta tcaatcagcc actagatgat tctgaagctc aaaaggaacg
    41701 cctagaaaag gctatccgat acttgattaa acggaaataa atgaatgttt tgagacgata
    41761 tgtgcaaagg tctattaact attagaatag tttaatgtga gtcaaaagaa gttgtaaaaa
    41821 atctttaaaa ttaaaaaaac gcatagtatc aggtgttgaa tgtactgacc cccaaaagtt
    41881 agattttttc tgtctaactt ttggggtgca gttcataaga accttggtac tatgcgtttt
    41941 attatgtaga gacttatact cttcgaaaat ctcttcaaac cacgtcagct tcaccttgcc
    42001 gtagatatgg ttactgactt cgtcagttct atccacaacc tcaaaacagt gttttgagct
    42061 gacttcgtca gttccatcca caaccttaaa acagtgtttt gagcagcttg cggctaactt
    42121 cctagtttgc actttaattt tcattgagta ttacttcatc ttctcatgaa attgagtttt
    42181 tgcccagctc ctcttgatta ttctacttga ccgggccaag cattcatacc accttctacg
    42241 ttggtaacgg tgaggccttg ggagctgaga aattggcagg tagatgcaga gcggactcct
    42301 ccttgacaaa tgacatagta ttcatggtca ggtttgagtt ctttgtagcc ttgctctaag
    42361 gtacttaatg gaagattttt ggcacctggt gcatgtcctg cttggaattc atgtgcttca
    42421 cggacatcga taagttctag attttcattt tggtattttc cataaaagtc agccatgctg
    42481 atactagttt ccatattcta ctccttctgg gttaaccatt ttgtatagtg aataagcgcc
    42541 gtcaaggttt tgggcggtaa atcctgcttg cttgaggata ggctctgcga tatagctgcg
    42601 caaaccactg tggcagctga cgatgtaggc ttgttttttg tccagttcat cagcttcctc
    42661 cttgacactc ggtcagattt tgatacaata gtacaaaatt agaggaggtg ggctatgatt
    42721 cagaaacatg cgattcccat tttagagttt gatgataatc ctcaggcggt tatcatgccc
    42781 aatcacgagg ggttggattt gcagttgcca aagaagtgtg tctatgcttt tttaggtgag
    42841 gagattgacc gctatgcgag ggaagtaggg gcgaactgtg ttggcgaatt cgtttctgct
    42901 accaagacct atccagtcta tgtcatcaac tacaagggtg aggaggtctg tctggctcag
    42961 gctcctgttg gctccgctcc agcagcccag tttatggatt ggttgattgg ctatggtgtg
    43021 gagcagatta tctctactgg gacctgtggt gtcctagctg atatagagga aaatgccttt
    43081 ctagtccctg ttcgcgcttt gcgagatgag ggagccagtt accactatgt ggcaccttgt
    43141 cgttatatgg aaatgcagcc agaggctatt gctgctattg aggaagtttt ggaagacaga
    43201 gggattcctt atgaagaaat catgacctgg acgacagacg gtttttaccg agaaacggct
    43261 gaaaaggtgg cttatcgtaa ggaagaaggc tgtgctgttg tggagatgga gtgttctgct
    43321 cttgcggcag tagctcaatt gcgtggggtt ctctggggtg aattgttgtt cacagcagat
    43381 tctctagcgg acttggacca gtacgacagt cgtgactggg gctcggaagc ttttaataag
    43441 gcgctagaac tgagtttagc aagtgttcac cacctttagt tgtactggca aaggatttgt
    43501 tttatcataa aatgtctagc tcatactttt caaaaatatg tttaaacgag gtcaccttcc
    43561 tcttgtccta ggcatgttga ggttgggaaa aatctttaaa atcagaaaaa cgtatcatat
    43621 caggtgatga aaactttgat actatgcgtt ttatgttggt aagatttaga gtgagatgaa
    43681 atgatactct tcgaaaatct tttcaaacca ggtcagcttc accttgccgt atagatgtta
    43741 ctgacttcgt cagttctatc tgcaacctca aaacagtgtt ttgagctgac ttcgtcagtt
    43801 ctatccacaa cctcaaaaca gtgttttgag taacctgtga ctagctttct aagcgatgcc
    43861 ttggttctca ttgcctataa tcaaaaagag aaattttctc ctgaaaagca tatagagtag
    43921 ctggcgttaa aagctcctgt ctcgcttttt tgacctatag tcacatctat caagtattgt
    43981 tcttgcctaa gctatcaata aaaaggtggc attttttagg cttggtgtta gtagattttg
    44041 ccttatccta tctaagtcat ttcgaacttt ttatggtaca atggaaacat gttattcaaa
    44101 ttatctaagg aaaaaataga gctaggctta tctcgtttat cgccagcccg tcgtattttt
    44161 ttgagttttg ccttggtcat tttactaggc tctcttcttt tgagcttgcc ctttgtccaa
    44221 gttgaaagct cacgagcgac ttattttgat catcttttca ctgctgtctc tgcagtctgt
    44281 gtgacaggtc tctcaaccct tccagtagct cacacctata atatatgggg ccaaataatc
    44341 tgtttgctct tgattcagat cggtggtcta gggctcatga cctttattgg ggttttctat
    44401 atccagagca agcaaaagct tagtcttcgt agccgtgcaa ctattcagga tagttttagt
    44461 tatggagaaa ctcgatcttt gagaaagttt gtctattcta tttttctcac gacctttttg
    44521 gttgagagct tgggagctat tttgcttagt tttcgcctta ttcctcaact tggctgggga
    44581 cgtggtcttt ttagttccat ttttctagcg atctcagcct tctgtaatgc cggttttgat
    44641 aatttaggga gcaccagttt atttgctttt cagaccgatt tactggtcaa tctggtgatt
    44701 gcaggcttga ttattacagg cggccttggt tttatggtct ggtttgattt ggctggtcat
    44761 gtaggaagaa agaaaaaagg acgtctgcac tttcatacga agcttgtact attgttgact
    44821 ataggtttgt tgttatttgg aacggcaact actctctttc ttgagtggaa caatgctgga
    44881 acgattggca atctccctgt tgccgataag gttttagtta gcttttttca aacagtgacg
    44941 atgcgaacag ctggcttttc tacgatagat tatactcagg ctcatcctgt gactcttttg
    45001 atttatatct tacagatgtt tctaggtggg gcacctggag gaacagctgg gggactcaag
    45061 attacgacat tttttgtcct cttggtcttt gcacgaagtg agcttctagg cttgcctcat
    45121 gccaatgttg cgagacgaac gattgcgtcg cgaacggttc aaaaatcctt tagtgtcttt
    45181 attatctttt tgatgagctt cttgatagga ttgattctgc tagggataac agccaaaggc
    45241 aatcctccct ttatccacct catatttgaa accatttcag ctcttagtac agttggtgta
    45301 acggcaaatc tgactcctga ccttgggaaa ttggctctca gtgttatcat gccacttatg
    45361 tttatgggac gaattggtcc cttgaccttg tttgttagct tggcagatta ccatccagaa
    45421 aagaaagata tgattcacta tatgaaagca gatattagta ttggttaaga aaggaaagag
    45481 catgtcagat cgtacgattg gaattttggg cttgggaatt tttgggagca gtgtcctagc
    45541 tgccctagcc aagcaggata tgaatattat cgctattgat gaccacgcag agcgcatcaa
    45601 tcagtttgag ccagttttgg cgcgtggagt gattggtgac atcacagatg aagaattatt
    45661 gagatcagca gggattgata cctgcgatac cgttgtagtc gcgacaggtg aaaatctgga
    45721 gtcgagtgtg cttgcggtta tgcactgtaa gagtttgggg gtaccgactg ttattgctaa
    45781 ggtcaaaagt cagaccgcta agaaagtgct agaaaagatt ggagctgact cggttatctc
    45841 gccagagtat gaaatggggc agtctctagc acagaccatt cttttccata atagtgttga
    45901 tgtctttcag ttggataaaa atgtgtctat cgtggagatg aaaattcctc agtcttgggc
    45961 aggtcaaagt ctgagtaaat tagacctccg tggcaaatac aatctgaata ttttgggttt
    46021 ccgagagcag gaaaattccc cattggatgt tgaatttgga ccagatgacc tcttgaaagc
    46081 agatacctat attttggcag tcatcaacaa ccagtatttg gataccctag tagcattgaa
    46141 ttcgtaaaga gggatgaccc ctcttttttg atgcccaaga tggcaaatag agacagaagc
    46201 cccttgtctt ctagtaaaag ttcttcaaag actggacttt atggtaaaat agaaagaagt
    46261 gacaagagag agtaatactc aatgaaaatc aaagatcaaa ctaggaaact agctacgggc
    46321 tgctcaaaac actgttttga ggttgtggat agaactgacg aagtcagctc aaaacactgt
    46381 tttgaggttg cagatagaac tgacgaagtc agtaacatct atacggcaag gcgacgttga
    46441 cgcggtttga agagattttc gaagagtata agaaaaaatc agtcccctaa aggagcagat
    46501 tatgaagtta ttgtctatcg ccatttctag ctataatgca gcagcctatc ttcattactg
    46561 tgtggagtcg ctagtgattg gtggtgagca agttgggatt ttgattatca atgacgggtc
    46621 tcaggatcag actcaggaaa tcgctgagtg tttagctagc aagtatccta atatcgttag
    46681 agccatctat cagaaaaata aatgccatgg cggtgcggtc aatcgtggct tggcagaggc
    46741 ttctgggcgc tattttaaag tagttgacag tgatgactgg gtggatcctc gtgcctactt
    46801 gaaaattctt gaaaccttgc aggaacttga gagcaagggt caagaggtgg atgtctttgt
    46861 gaccaatttt gtctatgaaa aggaagggca gtctcgtaag aagagtatga gttacgattc
    46921 agtcttgcct gttcggcaga tttttggctg ggaccaggtc ggaaatttct ccaaaggcca
    46981 gtataccatg atgcactcgc tgatttatcg gacagctttg ttgcgtgcta gccagttcta
    47041 attgcctgaa catacttttt atgtcgataa tctctttgtc tttacgcccc ttcagcaggt
    47101 caagaccatg tactatctgc ctgtcgattt ctatcgttat ttgattgggc gtgaggacca
    47161 gtctgtcaat gagcaagtga tgattaagtg cattgaccag caactcaagg tcaatcgact
    47221 cttggtagac cagcttgatt tgtcccaagt gagtcatcct aaaatgcgag aatatctgct
    47281 gaatcatatt gaaatcacga cggtgatttc cagtaccctg ctcaaccgat ctgaaacagc
    47341 ggagcatctg gcaaaaaaac gccaattgtg gacctatatt cagcaggaaa atccaaaagt
    47401 ctttcaggct attcgtaaga ccatgttgag ccgtttgacc aaacattctg tcttgccaga
    47461 tcgcaaactg tccaatgtcg tctatcaaat caccaaatct gtttatggat ttaattaata
    47521 taagtgtttt ataagaggga tttaagaaaa attttaactt tttcttagtc ctttttaatt
    47581 tcaggagatt atactagagt catcaaataa agaaagactc taaggagaat cctatgaaat
    47641 tcaatccaaa tcaaagatat actcgttggt ctattcgccg tctcagtgtc ggtgttgcct
    47701 cagttgttgt ggctagtggc ttctttgtcc tagttggtca gccaagttct gtacgtgccg
    47761 atgtggtcaa tccgacccca ggtcaagtct tacctgaaga gacatcggga acgaaagagg
    47821 gtgacttatc agaaaaacca ggagacaccg ttctcactca agcgaaacct gagggcgtta
    47881 ctggaaatac gaattcactt ccgacaccta cagaaagaac tgaagtgagc gaggaaacaa
    47941 actcttctag tctggataca ctttttgaaa aagatgaaga agctcaagaa aatccagagc
    48001 taacagatgc cttaaaagaa actgtagata cagctgatgt ggatgggaca caagcaagtc
    48061 cagcagaaac tactcctgaa caagtaaaag gtggagtgaa agaaaataca aaagacagca
    48121 tcgatgttcc tgctgcttat cttgaaaaag ctgaagggaa aggtcctttc actgccggtg
    48181 taaaccaagt aattccttat gaactattcg ctggtgatgg tatgttaact cgtctattac
    48241 taaaagcttc ggataatgct ccttggtctg acaatggtac tgctaaaaat cctgctttac
    48301 ctcctcttga aggattaaca aaagggaaat acttctatga agtagactta aatggcaata
    48361 ctgttggtaa acaaggtcaa gctttaattg atcaacttcg cgctaatggt actcaaactt
    48421 ataaagctac tgttaaagtt tacggaaata aagacggtaa agctgacttg actaatctag
    48481 ttgctactaa aaatgtagac atcaacatca atggattagt tgctaaagaa actgtcgaaa
    48541 aagctgttaa agataacgtt aaagacagta tcgatgttcc agcagcctac ctagaaaagg
    48601 ccaagggtga aggtccattc acagcaggtg tcaaccatgt gattccatac gaactcttcg
    48661 caggtgatgg catgttgact cgtctcttgc tcaaggcatc tgacaaggca ccatggtcag
    48721 ataacggtga ggctaaaaac ccagccctat ctccactagg
//
LOCUS       DAVHIZ010000009        47637 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.009, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000009 DAVHIZ010000000
VERSION     DAVHIZ010000009.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 47637)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47637)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47637
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.009"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            1..474
                     /gene="rlmH"
                     /locus_tag="VVO18_000516"
     CDS             1..474
                     /gene="rlmH"
                     /locus_tag="VVO18_000516"
                     /EC_number="2.1.1.177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (pseudouridine(1915)-N(3))-methyltransferase RlmH"
                     /protein_id="HEU5585724.1"
                     /translation="MKVVTVGKLKEKYLKDGIAEYSKRISRFAKFEMIELSDEKTPDK
                     ASESENQKILEIEGQRILSKIADRDFVIVLAIEGKTFFSEEFSKQLEETSIKGFSTLT
                     FIIGGSLGLSSSVKNRANLSVSFGRLTLPHQLMRLVLVEQIYRAFTIQQGFPYHK"
     gene            518..591
                     /locus_tag="VVO18_000517"
     tRNA            518..591
                     /locus_tag="VVO18_000517"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:552..554,aa:Arg,seq:tct)
     gene            756..881
                     /gene="comC"
                     /locus_tag="VVO18_000518"
     CDS             756..881
                     /gene="comC"
                     /locus_tag="VVO18_000518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence-stimulating peptide ComC"
                     /protein_id="HEU5585725.1"
                     /translation="MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK"
     gene            902..2227
                     /locus_tag="VVO18_000519"
     CDS             902..2227
                     /locus_tag="VVO18_000519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000362880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5585726.1"
                     /translation="MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTE
                     IVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQYERDRGLFLSLLLSLLYESTHNF
                     LSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
                     VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIA
                     LKQKKFEQKHLQNYTDEIVGLYNEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEV
                     LVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTLEVKDTITKLPIE
                     LLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFA
                     LGFSTKGRNRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE"
     gene            2224..2976
                     /locus_tag="VVO18_000520"
     CDS             2224..2976
                     /locus_tag="VVO18_000520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000866085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585727.1"
                     /translation="MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEE
                     YIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNPYAIIVFITSRSEFATLTYKYQV
                     SALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
                     IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRK
                     NLEIVFYEDHRCPISRLKIRKLKDILEKKSQK"
     gene            3028..3099
                     /locus_tag="VVO18_000521"
     tRNA            3028..3099
                     /locus_tag="VVO18_000521"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:3061..3063,aa:Glu,seq:ttc)
     gene            3105..3178
                     /locus_tag="VVO18_000522"
     tRNA            3105..3178
                     /locus_tag="VVO18_000522"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:3139..3141,aa:Asn,seq:gtt)
     gene            complement(3219..3761)
                     /locus_tag="VVO18_000523"
     CDS             complement(3219..3761)
                     /locus_tag="VVO18_000523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="HEU5585728.1"
                     /translation="MQESNKRLKTKRTIENAMVQLLMEQPFDKISTVKLVEKAGISRS
                     SFYTHYKDKYDMIEHYQSKLFHTFEYIFQKHAHHKRDAILEVFEYLESEPLLAALLSE
                     NGTKEIQNFLRNKLHIMLSTDLQKRFMQLNLNTTELEYSSIYLTHALFGVCQTWIAHG
                     KKESSQEITDFLMKMLGDTN"
     gene            3847..4993
                     /locus_tag="VVO18_000524"
                     /pseudo
     CDS             3847..4993
                     /locus_tag="VVO18_000524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007518194.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="YhgE/Pip family protein"
     gene            complement(5023..7575)
                     /locus_tag="VVO18_000525"
     CDS             complement(5023..7575)
                     /locus_tag="VVO18_000525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfhO family protein"
                     /protein_id="HEU5585729.1"
                     /translation="MKSFLKTYRTYFISFIIPVVIMSGVYLSQGIYWNSDNSPLLGDG
                     FHQYVIFDVALRNILHGNSSLFYTFTSGLGLNFYALSSYYLGSFLAPLVYFFDLTNMP
                     DAVYLTTLLKFGLIGLSTFFSLNKLFQSIPQTLKLALSTSYALMSFTVSQLEIKTWLD
                     VFILIPLIITGLHLLITEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDF
                     KTRKSSVLDFIVISFLAGMASLIMTLPTLFDLQTHGEKLTEVTKFQTESSWYLDLFAK
                     QFIGSFDTTKYGAIPMIFVGLLPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFYIE
                     ALDLFWQGMHTPNMFLHRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFL
                     ATIYLKSHYSFLTDLNILLTLEFLVVYSLLLLAVIKKFISVNLFAILISLFILVEMSL
                     NASSQMDGIAKEWGFASRSAYSRDIPAMESFSTYIGNQFTRTEKLQTQTGNDSMKFNY
                     NGISQFSSVRNRSSSSTLDKLGFKSSGTNLNLRYANNSILADSLFGIQYNISDSPIDK
                     YGFKDIYQKDNLTLYENQYSLPIAVASQSVYNDVKFNEHTLDNQASFLNQLANVNFDY
                     FSPIPYEKTEKIENTNDLISVTSSSNEDAAIQYQIEVPENSQVYLSFINLHFSNDKQK
                     KVDILVNGEKKTFTTDNVFSFFNLGYTKEKKTFNINVSFPGNSQVSFESPTFYRLDTK
                     TFTEAIQKIKEQPVTVSTSKNKVFATYDVQQDTSIFFTIPYDKGWSAYQDGKKIEIKQ
                     AQTGFMKVDIPKGKGTITLSFIPNGFITGAICSFTSLLLFGIYNHRRKSSKA"
     gene            complement(7637..9259)
                     /locus_tag="VVO18_000526"
     CDS             complement(7637..9259)
                     /locus_tag="VVO18_000526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5585730.1"
                     /translation="MLTVSDVSLRFSDRKLFDDVNIKFTEGNTYGLIGANGAGKSTFL
                     KILAGDIEPTTGHISLGPDERLSVLRQNHFDYEDERAIDVVIMGNEKLYSIMKEKDAI
                     YMKEDFSDEDGVRAAELEGEFAELGGWEAESEASQLLQNLNIPEELHYQNMSELANGE
                     KVKVLLAKALFGKPDVLLLDEPTNGLDIQSITWLEDFLIDFDNTVIVVSHDRHFLNKV
                     CTHMADLDFGKIKLYVGNYDFWKESSELAAKLLADRNAKAEEKIKQLQEFVARFSANA
                     SKSRQATSRKKMLDKIELEEIVPSSRKYPFINFKAEREIGNDLLTVENLTVKIDGETI
                     LDNISFILRPDDKTALIGQNDIQTTALIRAIMGDIDYEGTVKWGVTTSQSYLPKDNSA
                     DFAGGESILDWLRQFASKEEDDNTFLRGFLGRMLFSGDEVNKPVNVLSGGEKVRVMLS
                     KLMLLKSNVLVLDDPTNHLDLESISSLNDGLKNFKESIIFASHDHEFIQTLANHIIVL
                     SKNGVIDRIDETYDEFLENAEVQAKVKELWKD"
     gene            9465..10490
                     /gene="trpS"
                     /locus_tag="VVO18_000527"
     CDS             9465..10490
                     /gene="trpS"
                     /locus_tag="VVO18_000527"
                     /EC_number="6.1.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan--tRNA ligase"
                     /protein_id="HEU5585731.1"
                     /translation="MTKPIILTGDRPTGKLHIGHYVGSLKNRVLLQEEDKYDMFVFLA
                     DQQALTDHAKDPQTIVESIGNVALDYLAVGLDPNKSTIFIQSQIPELAELSMYYMNLV
                     SLARLERNPTVKTEISQKGFGESIPTGFLVYPIAQAADITAFKANYVPVGTDQKPMIE
                     QTREIVRSFNNAYNCDVLVEPEGIYPENERAGRLPGLDGNAKMSKSLNNGIYLADDAD
                     TLRKKVMSMYTDPDHIRVEDPGKIEGNMVFHYLDVFGRPEDAQEIADMKERYQRGGLG
                     DVKTKRYLLEILERELGPIRERRIEFAKDMGEVYNMIQKGSERAREVAGQTLSEVKGA
                     MGLHYFN"
     gene            10642..12120
                     /gene="guaB"
                     /locus_tag="VVO18_000528"
     CDS             10642..12120
                     /gene="guaB"
                     /locus_tag="VVO18_000528"
                     /EC_number="1.1.1.205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IMP dehydrogenase"
                     /protein_id="HEU5585732.1"
                     /translation="MSNWDTKFLKKGFTFDDVLLIPAESHVLPNDADLTTKLADNLTL
                     NIPIITAAMDTVTESQMAIAIARAGGLGVIHKNMSIAQQADEVRKVKRSENGVIIDPF
                     FLTPEHTIAEADELMGRYRISGVPVVETLENRKLVGILTNRDLRFISDYNQPISNHMT
                     SENLVTAPVGTDLATAESILQEHRIEKLPLVDEEGSLSGLITIKDIEKVIEFPNAAKD
                     EFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDR
                     TLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAAVAR
                     EYGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRG
                     MGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMIGGIRSGMGY
                     CGAANLKELHDNAQFIEMSGAGLKESHPHDVQITNEAPNYSM"
     gene            complement(12171..13268)
                     /gene="recF"
                     /locus_tag="VVO18_000529"
     CDS             complement(12171..13268)
                     /gene="recF"
                     /locus_tag="VVO18_000529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000266665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA replication/repair protein RecF"
                     /protein_id="HEU5585733.1"
                     /translation="MWLQHLSLKTFRNYKETKIDFNPKLNVFLGRNAQGKTNMLEAIY
                     FLALTRSHRTRTDKNLIHFDEEQLHLSGLVQKKTGSIPLEIELTQKGRVTKVNHLKQA
                     RLSDYVGHMNVVLFAPEDLQLIKGAPSIRRKFIDMELGQIKPIYLSDLTNYNHILKQR
                     NTYLKSAQKIDETFLSVLDDQLVDYGCRVMNHRLDFIKKLESFGRKKHFELSNQIEEL
                     SISYQSSVNITDKQNLSESFKIALEKSRSRDLFKKNTGVGPHRDDISFYINGMDASFG
                     SQGQHRSLVLSIKLAEIELMESITTESPILLLDDVMSELDNTRQLKLLETISQSIQTF
                     ITTTSLDHLQNLPENLSIFTIQDGKASVNGN"
     gene            complement(13271..13639)
                     /gene="yaaA"
                     /locus_tag="VVO18_000530"
     CDS             complement(13271..13639)
                     /gene="yaaA"
                     /locus_tag="VVO18_000530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S4 domain-containing protein YaaA"
                     /protein_id="HEU5585734.1"
                     /translation="MEYKLFEEFITLQALLKELGITHSGGAIKSFLSEHSVYFNRELE
                     SRRGKKLRIGDKVDIPDMNIDILLTQPTSEEQDEYQADKVEKERIAKLVKKMNKGVKK
                     DKSKPASSPKSQQAPRFPGR"
     gene            13798..15048
                     /locus_tag="VVO18_000531"
     CDS             13798..15048
                     /locus_tag="VVO18_000531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEU5585735.1"
                     /translation="MELVHGISTHFIQSKKFKTNKITVRFTAPLALDTIAGHMLSASM
                     LETANQMYPTSQDLRRHLASLYGTDMSTNCFRRGQSHIIELTFTYVRDEFLSRKNVLT
                     SQILELVKETLFSPVVVDNGFDPALFEIEKKQLLASLAADMDDSFYFAHKELDKLFFH
                     DERLQLEYSDLRNRILDETPQSSYSCFQEFLANDRIDFFFLGDFNEVEIQNVLESFGF
                     KGRKGDVKVQYCQPYSNILQEGMVRKNVGQSILELGYHYRSKYGDEQHLPMIVMNGLL
                     GGFAHSKLFTNVRENAGLAYTISSELDLFSGFLRMYAGINRENRNQARKMMNNQLLDL
                     KKGYFTEFELNQTKEMIRWSLLLSQDNQSSLIERTYQNALFGKSSADFKSWIAKLEQI
                     DKDAICRVANNVKLQAIYFMEGIE"
     gene            15045..16328
                     /locus_tag="VVO18_000532"
     CDS             15045..16328
                     /locus_tag="VVO18_000532"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="insulinase family protein"
                     /protein_id="HEU5585736.1"
                     /translation="MTKVVFEEKYYPAVKEKVYRTRLANGLTVALLPKKEFKEVYGSV
                     TVQFGSVDTFVTEVDGDVKQYPGGIAHFLEHKLFEREDSSDLMSAFTSLGADSNAFTS
                     FTKTNYLFSATDYFLENLYLLDELVTSAHFTEASILTEQDIIQQEREMYQDDPDSCLF
                     FSTLANLYPGTPLATDIVGSEESISQINLTNLQENFTKFYKPVNMSLFLVGNFDVERV
                     QDYFESKELKDSDFQEVAREKLFLQPVKPTDSMRMEVSSPKLAIGVRGKREVSEADCY
                     RHHILLKLLFAMMFGWTSDRFQKCYESGKIDASLSLEVEVTSRFHFVMLTMDTKEPVA
                     LSHQFRKAIRNFTKDLDITEEHLDIIKREMFGEFFSSMNSLEFIATQYDAFENGETIF
                     DLPKILQEITLEDVLDAGHHLIDDGDIVDFTIFPS"
     gene            16370..17191
                     /locus_tag="VVO18_000533"
     CDS             16370..17191
                     /locus_tag="VVO18_000533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5585737.1"
                     /translation="MRKKTIGEVLRLARINQGLSLDELQKKTEIQLDMLEAMEADDFD
                     QLPSPFYTRSFLKKYAWAVELDDQIVLDAYDSGSMITYEEVDVDEDELTGRRRSSKKK
                     KKKTSFLPLFYFILFALSILIFVTYYVWNYIQTQPEEPSLSNYSVVQSTSSTSSVPHS
                     SSSSSSSIESAISVSGEGNHVEIAYKTSKETVKLQLAVSDVTSWVSVSESELEGGVTL
                     SPKKKSAEATVATKSPVTITLGVVKGVDLTVDNQTVDLSKLTAQTGQITVTFTKN"
     gene            17202..17747
                     /gene="pgsA"
                     /locus_tag="VVO18_000534"
     CDS             17202..17747
                     /gene="pgsA"
                     /locus_tag="VVO18_000534"
                     /EC_number="2.7.8.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase"
                     /protein_id="HEU5585738.1"
                     /translation="MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVA
                     SITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSAFIVLIELGMAPAWIVAVIICRE
                     LAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
                     YSGYDYFKGSAYVFKGTFGSK"
     gene            17744..18571
                     /locus_tag="VVO18_000535"
     CDS             17744..18571
                     /locus_tag="VVO18_000535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEU5585739.1"
                     /translation="MKSIIDVKNLSFRYKENQNYYDVKDITFHVKRGEWLSIVGHNGS
                     GKSTTVRLIDGLLEAESGEIVIDGQRLTEENVWNIRRQIGMVFQNPDNQFVGATVEDD
                     VAFGLENQGLSRQEMKKRVEEALALVGMLDFKKREPARLSGGQKQRVAIAGVVALRPA
                     ILILDEATSMLDPEGRRELIGTVKGIRKDYDMTVISITHDLEEVAMSDRVLVMKKGEI
                     ESTSSPRELFSRNDLDQIGLDDPFANQLKKSLSQNGYDLPENYLTESELEDKLWELL"
     gene            18556..19395
                     /locus_tag="VVO18_000536"
     CDS             18556..19395
                     /locus_tag="VVO18_000536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000510406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter ATPase"
                     /protein_id="HEU5585740.1"
                     /translation="MGIALENVNFTYQEGTPLASAALSDVSLTIEDGSYTALIGHTGS
                     GKSTILQLLNGLLVPSQGSVRVFDTLITSTSKNKDIRQIRKQVGLVFQFAENQIFEET
                     VLKDVAFGPQNFGVSEEDAVKTAREKLALVGIDESLFDRSPFELSGGQMRRVAIAGIL
                     AMEPAILVLDEPTAGLDPLGRKELMTLFKKLHQSGMTIVLVTHLMDDVAEYANQVYVM
                     EKGRLVKGGKPSDVFQDVVFMEEVQLGVPKITAFCKRLADRGVSFKRLPIKIEEFKES
                     LNG"
     gene            19388..20182
                     /locus_tag="VVO18_000537"
     CDS             19388..20182
                     /locus_tag="VVO18_000537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU5585741.1"
                     /translation="MDSMILGRYIPGDSIVHRLDPRSKLLAMMLLILIVFWANNPLTN
                     LILFIATGIFIALSGVSLSFFIQGLKSMFFLIAFTTIFQLFFISNGNVLFEFSFVRIT
                     DYALQQAGIIFCRFVLIIFFSTLLTLTTMPLSLASAVEALLAPLKRVKVPVHEIGLML
                     SMSLRFVPTLMDDTTRIMNAQKARGVDFGEGSIVQKVKAMIPILIPLFATSLKRADSL
                     AIAMEARGYQGGKGRSQYRQLKWTLKDTLTILVILVLGCCLFFLKS"
     gene            20241..21059
                     /gene="mreC"
                     /locus_tag="VVO18_000538"
     CDS             20241..21059
                     /gene="mreC"
                     /locus_tag="VVO18_000538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001078980.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreC"
                     /protein_id="HEU5585742.1"
                     /translation="MNRFKKSKYVIIVFVTVLLVSALLATTYSSTIVTKLGDGISLVD
                     RVVQKPFQWFDSVKSDLAHLTRTYNENESLKKQLYQLEVKSNEVESLKTENEQLRQLL
                     DMKSKLQATKTLAADVIMRSPVSWKQELTLDAGRSKGASENMLAIANGGLIGSVSKVE
                     ENSTIVNLLTNTENADKISVKIQHGSTTIYGIIIGYDKENDVLKISQLNSNSDISAGD
                     KVTTGGLGNFNVADIPVGEVVATTHSTDYLTREVTVKLSADTHNVDVIELVGNS"
     gene            21059..21553
                     /gene="mreD"
                     /locus_tag="VVO18_000539"
     CDS             21059..21553
                     /gene="mreD"
                     /locus_tag="VVO18_000539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001249461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rod shape-determining protein MreD"
                     /protein_id="HEU5585743.1"
                     /translation="MRQLKRVGVFLLLPFFVLIDAHISQLLGSFFPHVHLASHFLFLF
                     LLFETIEVSEYLYLVYCFVIGLVYDVYFFHLIGITTLLFILLGAFLHKLNSVILLNRW
                     TRMLAMIVLTFLFEMGSYLLAFMVGLTVDSMSIFIVYSLVPTMILNFLWITVFQFIFE
                     KYYL"
     gene            21647..22825
                     /locus_tag="VVO18_000540"
     CDS             21647..22825
                     /locus_tag="VVO18_000540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CHAP domain-containing protein"
                     /protein_id="HEU5585744.1"
                     /translation="MKKKILASLLLSTVMVSQVAVLTTAHAETTDDKIAAQDNKISNL
                     TAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQ
                     SLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKA
                     ISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLL
                     EQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKV
                     RPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIA
                     CWNDGGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD
                     "
     gene            23049..23828
                     /gene="rpsB"
                     /locus_tag="VVO18_000541"
     CDS             23049..23828
                     /gene="rpsB"
                     /locus_tag="VVO18_000541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000268478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S2"
                     /protein_id="HEU5585745.1"
                     /translation="MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQ
                     QTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLT
                     NWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDV
                     MYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLA
                     DAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA"
     gene            23907..24947
                     /locus_tag="VVO18_000542"
     CDS             23907..24947
                     /locus_tag="VVO18_000542"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003053075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Ts"
                     /protein_id="HEU5585746.1"
                     /translation="MAEITAKLVKELREKSGAGVMDAKKALVETDGDIEKAIELLREK
                     GMAKAAKKADRVAAEGLTGVYVNGNVAAVIEVNAETDFVAKNAQFVELVNTTAKVIAE
                     GKPANNEEALALIMPSGETLEAAYVSATATIGEKISFRRFALIEKTDAQHFGAYQHNG
                     GRIGVISVVEGGDEALAKQLSMHIAAMKPTVLSYKELDEQFVKDELAQLNHVIDQDNE
                     SRAMVNKPALPHLKYGSKAQLTDDVIAQAEADIKAELAAEGKPEKIWDKIIPGKMDRF
                     MLDNTKVDQAYTLLAQVYIMDDSKTVEAYLESVNASVVEFARFEVGEGIEKAANDFEA
                     EVAATMAAALNN"
     gene            25193..25516
                     /gene="tnpB"
                     /locus_tag="VVO18_000543"
     CDS             25193..25516
                     /gene="tnpB"
                     /locus_tag="VVO18_000543"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
                     /protein_id="HEU5585747.1"
                     /translation="MMIQLSDLGQVHIVCGKTDMRQGIDSLAYVVKTHFELDSFSGQV
                     FLFCGGRKDRFKVLYWDGQGFWLLYKRFENGKLTWLSTEKDVKALTSEQVDWLMKGFS
                     ITPQI"
     gene            complement(25657..25965)
                     /locus_tag="VVO18_000544"
                     /pseudo
     CDS             complement(25657..25965)
                     /locus_tag="VVO18_000544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            25956..26354
                     /locus_tag="VVO18_000545"
     CDS             25956..26354
                     /locus_tag="VVO18_000545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000841825.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5585748.1"
                     /translation="MKSPIPKAPLAHNFGSASIIAHTIHQKFNLKVPNYRQEEDWARM
                     GLPITRKEISNRHIKTSQYYLEPLYNLLRERLLTQPLLHADETSYRVLESDSQLTYYW
                     TFLSGKAEKQGITLYHHVLIDLFISYFNPL"
     gene            complement(26551..27471)
                     /gene="cysK"
                     /locus_tag="VVO18_000546"
     CDS             complement(26551..27471)
                     /gene="cysK"
                     /locus_tag="VVO18_000546"
                     /EC_number="2.5.1.47"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine synthase A"
                     /protein_id="HEU5585749.1"
                     /translation="MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVK
                     DRIALSMIEKAEQDGILKLGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVER
                     RKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
                     ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPH
                     KIQGISAGFIPDTLDTKAYDGIVRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIE
                     VAKKLGTGKKVLALAPDNGERYLSTALYEL"
     gene            complement(27756..28391)
                     /locus_tag="VVO18_000547"
     CDS             complement(27756..28391)
                     /locus_tag="VVO18_000547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YigZ family protein"
                     /protein_id="HEU5585750.1"
                     /translation="MEFRTIKEDGQVQEEIKKSRFICHAKRVYSEEEARDFITAIKKE
                     HYKATHNCSAFIIGERSEIKRTSDDGEPSGTAGVPMLGVLENHNLTNVCVVVTRYFGG
                     IKLGAGGLIRAYTSSVALAVKEIGIIEIKEQAGIAIQMSYAQYQEYSNFLKEHDLMEL
                     DTNFTDQVDTMIYVDKEEKETIKAALVEFFNGKVTLTDQGLREVEVPVNLV"
     gene            28447..29745
                     /locus_tag="VVO18_000548"
     CDS             28447..29745
                     /locus_tag="VVO18_000548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU5585751.1"
                     /translation="MKVNLDYLGRLFTENELTEEERQLAEKLPAMRKEKGKLFCQRCN
                     STILEEWYLPIGAYYCRECLLMKRVRSDQTLYYFPQEDFPKQDVLKWRGQLTPFQEKV
                     SEGLLQAVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKR
                     LQQDFSCGIALLHGESEPYFRTPLVVATTHQLLKFYQAFDLLIVDEVDAFPYVDNPTL
                     YHAVKNSVKENGLRIFLTATSTNELDKKVRLGELKRLNLPRRFHGNPLIIPKPIWLSD
                     FNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLEEILQEQFPNEKIGFVS
                     SVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGG
                     RVGRSMDRPTGDLLFFHDGLNASIKKAIKEIQMMNKEAGL"
     gene            29742..30404
                     /locus_tag="VVO18_000549"
     CDS             29742..30404
                     /locus_tag="VVO18_000549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649954.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComF family protein"
                     /protein_id="HEU5585752.1"
                     /translation="MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEEN
                     CPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQAMKDFFSRYKFDGDFLLRKVFA
                     SFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
                     KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSL
                     VR"
     gene            30484..31032
                     /gene="raiA"
                     /locus_tag="VVO18_000550"
     CDS             30484..31032
                     /gene="raiA"
                     /locus_tag="VVO18_000550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000599099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="HEU5585753.1"
                     /translation="MIKYSIRGENLEVTEAIRDYVVSKLEKIEKYFQPEQELDARINL
                     KVYREKTAKVEVTIPLGSITLRAEDVSQDMYGSIDLVTDKIERQIRKNKTKIERKNKN
                     KVATGQLFTDALVEDSNIVQSKVVRSKQIDLKPMDLEEAILQMDLLGHDFFIYVDVED
                     QTTNVIYRREDGEIGLLEVKES"
     gene            31168..33141
                     /locus_tag="VVO18_000551"
     CDS             31168..33141
                     /locus_tag="VVO18_000551"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255323.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DHH family phosphoesterase"
                     /protein_id="HEU5585754.1"
                     /translation="MKKFYVSPIFPILVGLIAFGVLSTFIIFVNNNLLTVLILFLFVG
                     GYVFLFKKLRVHYTRSDVEQIQYVNHQAEESLTALLEQMPVGVMKLNLSSGEVEWFNP
                     YAELILTKEDGDFDLEAVQTIIKASVGNPSTYAKLGEKRYAVHMDASSGVLYFVDVSR
                     EQAITDELVTSRPVIGIVSVDNYDDLEDATSESDISQINSFVANFISEFSEKYMMFSR
                     RVSMDRFYLFTDYTVLEGLMNDKFSVIDAFREESKQRQLPLTLSMGFSYGDGNHDEIG
                     KVALLNLNLAEVRGGDQVVVKENDETKNPVYFGGGSAASIKRTRTRTRAMMTAISDKI
                     RSVDQVFVVGHKNLDMDALGSAVGMQLFASNVIENSYALYDEEQMSPDIERAVSFIEK
                     EGVTKLLSVKDAMGMVTNRSLLILVDHSKTALTLSKEFYDLFTQTIVIDHHRRDQDFP
                     DNAVITYIESGASSASELVTELIQFQNSKKNRLSRMQASVLMAGMMLDTKNFTSRVTS
                     RTFDVASYLRTRGSDSIAIQEIAATDFEEYREVNELILQGRKLGSDVLIAEAKDTKCY
                     DTVVISKAADAMLAMSGIEASFVLAKNTQGFISISARSRSKLNVQRIMEELGGGGHFN
                     LAAAQIKDVTLSEAGEKLTEIVLNEIKEKEKEE"
     gene            33138..33590
                     /gene="rplI"
                     /locus_tag="VVO18_000552"
     CDS             33138..33590
                     /gene="rplI"
                     /locus_tag="VVO18_000552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999581.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L9"
                     /protein_id="HEU5585755.1"
                     /translation="MKVIFLADVKGKGKKGEIKEVPTGYAQNFLIKKNLAKEATAQAV
                     GELRGKQKSEEKAHAEMIAEGKAIKAQLEAEETVVEFVEKVGPDGRTFGSITNKKIAE
                     ELQKQFGIKIDKRHIQVQAPIRAVGLIDVPVKIYQDITSVINLRVKEG"
     gene            33634..34986
                     /gene="dnaB"
                     /locus_tag="VVO18_000553"
     CDS             33634..34986
                     /gene="dnaB"
                     /locus_tag="VVO18_000553"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replicative DNA helicase"
                     /protein_id="HEU5585756.1"
                     /translation="MAEVEELRVQPQDILAEQSVLGAIFIDESKLVFVREYIESRDFF
                     KYAHRLIFQAMVDLSDRGDAIDATTVRTILDNQGDLQNIGGLSYLVEIVNSVPTSANA
                     EYYAKIVAEKAMLRRLIAKLTESVNQAYEASQPADEIIAQAEKGLIDVSENANRSGFK
                     NIRDVLNLNFGNLEARSQQTTDITGIATGYRDLDHMTTGLHEEELIILAARPAVGKTA
                     FALNIAQNIGTKLDKTVAIFSLEMGAESLVDRMLAAEGLVESHSIRTGQLTDEEWQKY
                     TIAQGNLANASIYIDDTPGIRITEIRSRSRKLAQETGNLGLILIDYLQLITGTGRENR
                     QQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIV
                     AFLYRDDYYERGGEEEEGIPNNKVEVIIEKNRSGARGTVELIFQKEYNKFSSISKREA
                     "
     gene            34988..35254
                     /locus_tag="VVO18_000554"
     CDS             34988..35254
                     /locus_tag="VVO18_000554"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001278167.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585757.1"
                     /translation="MSDAFTDVAKMKKIKEEIKAHEGQVVEMTLENGRKRQKNRLGKL
                     IEVYPSLFIVEFGDVEGDKQVNVYVESFTYSDILTEKNLIHYLD"
     gene            35343..36689
                     /gene="cbpD"
                     /locus_tag="VVO18_000555"
     CDS             35343..36689
                     /gene="cbpD"
                     /locus_tag="VVO18_000555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698569.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline binding-anchored murein hydrolase CbpD"
                     /protein_id="HEU5585758.1"
                     /translation="MKILPFIARGTSYYLKMSVKKLVPFLVVGLMLAAGDSVYAYSRG
                     NGSIARGDDYPAYYKNGSQEIDQWRMYSRQCTSFVAFRLSNVNGFEIPAAYGNANEWG
                     HRARREGYRVDNTPTIGSITWSTAGTYGHVAWVSNVMGDQIEIEEYNYGYTESYNKRI
                     IKANTMTGFIHFKDLDGGSVGNSQSSTSTGGTHYFKTKSAIKTEPLVSATVIDYYYPG
                     EKVHYDQILEKDGYKWLSYTAYNGSYRYVQLEAVNKNPLGNSVLSSTGGTHYFKTKSA
                     IKTEPLVSATVIDYYYPGEKVHYDQILEKDGYKWLSYTAYNGSRRYIQLEGVTSSQNY
                     QNQSGNISSYGSNNSSTVGWKKINGSWYHFKSNGSKSTGWLKDGSSWYYLKLSGEMQT
                     GWLKENGSWYYLGSSGAMKTGWYQVSGKWYYSYSSGALAVNTTVDGYRVNSDGERV"
     regulatory      36772..36874
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
     gene            36945..37235
                     /locus_tag="VVO18_000556"
     CDS             36945..37235
                     /locus_tag="VVO18_000556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine-binding protein"
                     /protein_id="HEU5585759.1"
                     /translation="MKASIALQVLPLAQGIDRIAVIDQVIAYLQTQEVTMVVTPFETV
                     LEGEFDELMRILKEALEVAGQEADNVFANVKINVGEILSIDEKLEKYTETTH"
     gene            37198..37956
                     /locus_tag="VVO18_000557"
     CDS             37198..37956
                     /locus_tag="VVO18_000557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009013602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5585760.1"
                     /translation="MRNLKSILRRHISLLGFLGVLSIWQLAGFLKLLPKFILPTPLEI
                     LQPFVRDREFLWHHSWATLRVALLGLILGVLIACLMAVLMDSLTWLNDLIYPMMVVIQ
                     TIPTIAIAPILVLWLGYGILPKIVLIILTTTFPIIVSILDGFRHCDKDMLTLFSLMRA
                     KPWQILWHFKIPVSLPYFYAGLRVSVSYAFITTVVSEWLGGFEGLGVYMIQSKKLFQY
                     DTMFAIIILVSIISLLGMKLVDISEKYVIKWKRT"
     gene            37994..39001
                     /locus_tag="VVO18_000558"
     CDS             37994..39001
                     /locus_tag="VVO18_000558"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5585761.1"
                     /translation="MKKTWKVFLTLVTALVAVVLVACGQGTASKDNKEAELKKVDFIL
                     DWTPNTNHTGLYVAKEKGYFKEAGVDVDLKLPPEESSSDLVINGKAPFAVYFQDYMAK
                     KLEKGAGITAVAAIVEHNTSGIISRKSDNVSSPKDLVGKKYGTWNDPTELAMLKTLVE
                     SQGGDFEKVEKVPNNDSNSITPIANGVFDTAWIYYGWDGILAKSQGVDANFMYLKDYV
                     KEFDYYSPVIIANNDYLKDNKEEARKVIQAIKKGYQYAMEHPEEAADILIKNAPELKE
                     KRDFVIESQKYLSKEYASDKEKWGQFDAARWNAFYKWDKENGILKEDLTDKGFTNEFV
                     K"
     gene            39001..39729
                     /locus_tag="VVO18_000559"
     CDS             39001..39729
                     /locus_tag="VVO18_000559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585762.1"
                     /translation="MTEIRLEHVSYAYGQERILEDINLQVTSGEVVSILGPSGVGKTT
                     LFNLIAGILEVQSGRIVLDGEENPKGRVSYMLQKDLLLEHKTVLGNIILPLLIQKVDK
                     AEAISRADKILATFQLTAVRDKYPHELSGGMRQRVALLRTYLFGHKLFLLDEAFSALD
                     EMTKMELHAWYLEIHKQLQLTTLIITHSIEEALNLSDRIYILKNRPGQIVSEIKLDWS
                     EDEDKEVQKIAYKRQILAELGLDK"
     gene            39848..40306
                     /locus_tag="VVO18_000560"
     CDS             39848..40306
                     /locus_tag="VVO18_000560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211265.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CtsR family transcriptional regulator"
                     /protein_id="HEU5585763.1"
                     /translation="MRFKNTSDHIEAYIKAILDQSGIVELQRSQLADTFQVVPSQINY
                     VIKTRFTESRGYLVESKRGGGGYIRIGRIEFSSHHEILRELLYSIGERVSQEIYEDIL
                     QLLVEQELMTKQEMNLLVSVALDRVLGEEAPVVRANMLRQIIQEVDRKGK"
     gene            40308..42740
                     /locus_tag="VVO18_000561"
     CDS             40308..42740
                     /locus_tag="VVO18_000561"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001109706.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU5585764.1"
                     /translation="MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAG
                     ATLNDYPYEMDRLEEVALELTETDYSQDETFTELPFSRRLQVLFDEAEYVASVVHAKV
                     LGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
                     LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRM
                     IQILSRKTKNNPVLVGDAGVGKTALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAG
                     TRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDSTLDAANILKPALARG
                     TLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQ
                     ITDEAVETAVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKADDSDLSPADKAL
                     MDGKWKQAAQLIAKEEEVPVYKDLVTESDILTTLSRLSGIPVQKLTQTDAKKYLNLEA
                     ELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAKALAEVL
                     FDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVE
                     KAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDI
                     RFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSSDHMQEVVKIMVKPLVASLAE
                     KGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKI
                     GVKAGQLKFDIA"
     gene            43382..44035
                     /gene="rr06"
                     /locus_tag="VVO18_000562"
     CDS             43382..44035
                     /gene="rr06"
                     /locus_tag="VVO18_000562"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001024075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator RR06"
                     /protein_id="HEU5585765.1"
                     /translation="MNILVADDEEMIREGIAAFLTEEGYHVIMAKDGQEVLEKFQDLP
                     IHLMVLDLMMPRKSGFEVLKEINQKHDIPVIVLSALGDETTQSQVFDLYADDHVTKPF
                     SLVLLVKRIKALIRRYYVIEDLWRYQDVTVDFTSYKAHYKNEEIDLKPKELLVLKCLI
                     QHKNQVLSREQILEEISKDVADLPCDRVVDVYIRTLRKKLALDCIVTVKNVGYKISL"
     gene            44032..45363
                     /gene="hk06"
                     /locus_tag="VVO18_000563"
     CDS             44032..45363
                     /gene="hk06"
                     /locus_tag="VVO18_000563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000594665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     HK06"
                     /protein_id="HEU5585766.1"
                     /translation="MIKNPKLLTKSFLRSFAILGGVGLVIHIAIYLTFPFYYIQLEGE
                     KFNESARVFTEYLKTKTSDEIPSLLQSYSKSLTISAHLKRDIVDKRLPLVHDLDIKDG
                     KLSNYIVMLDMSVSTADGKQVTVQFVHGVDVYKEAKNILLLYLPYTFLVTIAFSFVFS
                     YFYTKRLLNPLFYISEVTSKMQDLDDNIRFDESRKDEVGEVGKQINGMYEHLLKVIHE
                     LESRNEQIVKLQNQKVSFVRGASHELKTPLASLRIILENMQHNIGDYKDHPKYIAKSI
                     NKIDQMSHLLEEVLESSKFQEWTECRETLTVKPVLVDILSRYQELAHSIGVTIENQLT
                     DATRVVMSLRALDKVLTNLISNAIKYSDKNGRVIISEQDGYLSIKNTCAPLSDQELEH
                     LFDIFYHSQIVTDKDESSGLGLYIVSNILESYQMDYSFLPYEHGMEFKISL"
     gene            45458..45985
                     /locus_tag="VVO18_000564"
     CDS             45458..45985
                     /locus_tag="VVO18_000564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241939.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenylcysteine carboxyl methyltransferase
                     family protein"
                     /protein_id="HEU5585767.1"
                     /translation="MVLAIILVTFLIRLIFLKRSIENEKRILSNGGKEFGVENTKRLT
                     LAHIVFYLSCLVEAMVHKTIFDGMGMVGLVLLIFSMLMLMLVIHLLGDIWTVKLMLVN
                     NHKYVDHILFRTVKHPNYFLNILPELIGLTLLSHAYVTFVLVFPVYAVILYRRIAEEE
                     KLLHEVIIPNGSIKR"
     gene            46064..>47637
                     /gene="pspC"
                     /locus_tag="VVO18_000565"
     CDS             46064..>47637
                     /gene="pspC"
                     /locus_tag="VVO18_000565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein PspC,
                     choline-binding form"
                     /protein_id="HEU5585768.1"
                     /translation="MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHAEEVGGRN
                     TPTVTSSGQDISKKYADEVESHLKKILSEIQTQLDRKRHTKTVALINELQNIKKTYLY
                     NLNVLKEKSELPSKIKAKLEVAFDQFKKDTLKPGEKVAEAEKKVAEAKKKAEDQKEQD
                     RRNYPTNTYKTLELEIAESDVKVKEAELELVKEEAKESRNEEKVKQAKAKVESEKAEA
                     IRLEEIKTDREEAKRKADAKLKEAVENNAATSEQGEPKRRVKRGVLGEPATPDKKEND
                     AKSSDSSVGEETLPSPSLKPEKKVAEAEKKVAEAEKKAKDQKEEDRRNYPTNTYKTLE
                     LEIAESDVKVKEAELELVKEEAKESRNEEKVKQAKAKVESKKAEATRLEKIKTDRKKA
                     EEAKRKAAEEAKRKAAEEDKVKEKPAEQPQPAPAPKPEKPAPAPKPENPAEQPKAEKP
                     AQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNANGSMATGWLQYNGSWY
                     YLNANGDMATGWLQNNG"
BASE COUNT        15159 a         7663 c        10170 g        14645 t
ORIGIN      
        1 attaaagttg taacagttgg gaaactgaaa gaaaagtatt taaaagatgg tatcgcagag
       61 tattcaaaac gaatttctag atttgctaag tttgaaatga ttgagttatc agatgaaaaa
      121 acaccagata aggccagtga atcagaaaat caaaagattt tagaaataga aggtcagaga
      181 attttatcaa aaattgctga ccgtgatttc gttattgtgt tagccattga agggaaaact
      241 ttcttctcag aagaatttag taagcagtta gaagaaactt ctataaaagg attttctact
      301 cttactttta ttattggggg aagtttagga ttgtcatcat ctgtaaaaaa tagagccaat
      361 ctttctgtca gttttggtcg cctaacctta ccccatcagt taatgagact agttcttgtt
      421 gaacaaatct atcgcgcttt tacgattcag cagggattcc cctaccataa atagaaaatt
      481 gacttttaat tgaatttttg gtagaataat tgtattaggt ctcatagctc agctggatag
      541 agcattcgcc ttctaagcga acggtcgcag gttcgaatcc tgctgggatc aatataatag
      601 caaagctggg aattttcccg gcttttttct taaaaaagta cactttggga gaaaaaaatg
      661 acagttgaga gaattttatc taaaacgaaa ttccattttg tataatggtt tttgtaagtt
      721 agcttacaag aaaaaacatt ttaggagatt ttattatgaa aaacacagtt aaattggaac
      781 agtttgtagc tttgaaggaa aaagacttac aaaagattaa aggtggggag atgaggttgt
      841 caaaattctt ccgtgatttt attttacaaa gaaaaaagta atgaaataag gggaaagagt
      901 aatggattta tttggatttg ggacggttat tgttcatttt ttaattatta gtcacagtta
      961 ccattttatt tgtaaaggtc aaataaatag aaaagaatta ttcgtttttg gtgcttatac
     1021 attactaaca gaaatagtat ttgattttcc cttatatatt ctatatttag atgggttagg
     1081 gattgaaaga tttttatttc ctttgggatt atattcctat tttcgatgga tgaaacagta
     1141 tgagagggat agaggactat tcctaagttt actactatct cttttatatg agagcactca
     1201 taactttctg tccgtaactt tctcctctat aacaggagat aattttgttt tacaatatca
     1261 tttcccattc tttttcgttg tgacggtgtt aacctatttt gttacattaa aaatcattta
     1321 ctatttccat ttggaactag cctattttga cgaggactac ctttatcctt tcttgaaaaa
     1381 agtatttttt gctttactat tgctacatat tgtatctttc gtttcagata tggtaagtac
     1441 gattaaacat ttgaatagtt ttggaagtat tttgtcatct attgtcttta tctctctcct
     1501 tttgaccttc tttgcaatga attctcataa agttcaaatg gagaaagaga ttgctttgaa
     1561 gcagaagaaa tttgaacaga aacatttaca gaattacaca gatgaaattg ttggtctgta
     1621 taatgaaatc cgtggttttc gacatgatta tgctggaatg cttgtcagca tgcagatggc
     1681 aattgacagt ggtaatttac aggaaattga cagaatttac aatgaagttt tagtcaaagc
     1741 aaatcataaa ttgcgttcag ataagtacac ttactttgat ttgaacaaca tagaagactc
     1801 agctttacga agtttggttg ctcagtcaat tgtctatgct cgaaataatg gtgtagagtt
     1861 tacactggaa gtaaaagata cgattaccaa gcttccaatt gaactattgg atttggttcg
     1921 tatcatgagc gttttattga ataatgctgt cgaaggatcg gctgatagct ataaaaagca
     1981 gatggaagta gcagttatta agatggaaac tgaaacagtt attgtgattc agaattcatg
     2041 taaaatgacg atgactcctt caggagatct atttgcctta ggattctcca ctaagggaag
     2101 aaatcgcgga gtcggattaa ataatgtgaa agaactacta gataagtaca acaatattat
     2161 tttagaaaca gagatggaag gcagtacatt tagacaaatc attagattta agagggaatt
     2221 tgaatgaaag ttttaatttt agaagatgtt attgaacatc aagtgagact agagagaata
     2281 ttggatgaaa tttcgaaaga atcgaatatt ccaatatcat acaagacaac gggaaaagtc
     2341 cgtgaatttg aagaatacat tgaaaatgat gaagtaaatc agctttattt cctagatatc
     2401 gatattcatg gaattgagaa aaagggattt gaagtggctc agctcattcg tcattacaat
     2461 ccttacgcta ttatcgtctt tatcactagt cgatcagagt ttgcgactct aacctataaa
     2521 tatcaggtat cagccctaga ttttgttgat aaggatatca atgatgagat gtttaagaag
     2581 agaattgagc aaaatatctt ctacacgaag agtatgttac ttgaaaatga agatgttgta
     2641 gattatttcg actacaatta caagggaaat gatttaaaaa ttccttacca tgatattttg
     2701 tatattgaaa caacaggggt atctcataaa ttgcgcatta ttggtaagaa ttttgcaaaa
     2761 gagttttatg gtaccatgac agatattcag gaaaaggaca aacatactca gcgattttat
     2821 tctcctcaca agtcattttt ggtaaatata ggcaatatca gagaaattga tcgaaaaaac
     2881 ttagaaattg ttttctatga agaccatcgt tgtcctattt caagattaaa aattagaaaa
     2941 ttaaaagata ttttagagaa aaaatctcaa aagtgattga caattagcaa gaaattgata
     3001 taatggttat atctgctaca gatagaaggt ccgttggtca aggggttaag acaccgcctt
     3061 ttcacggcgg taacacgggt tcgaatcccg tacggactat tttatccgcc atagctcagt
     3121 tggtagtagc gcatgactgt taatcatgat gtcgtaggtt cgagtcctac tggcggagta
     3181 tagataaaag ggaacacagc tgtgttcctc tttttgtatc aatttgtatc accaagcatt
     3241 ttcataagga agtctgttat ttcttgagaa ctttcttttt ttccatgtgc aatccaagtt
     3301 tggcagacac caaaaagtgc atgagttaga tagatgctac tatattctaa ttcggtggta
     3361 tttagattca gttgcataaa tcgcttttgt aaatctgtac taagcatgat atgaagttta
     3421 tttcgtaaga aattttggat ttctttagtc ccattttcag aaagaagggc agccagaagt
     3481 ggttctgact ctagatattc aaaaacttct aaaatagcgt ctcttttgtg atgagcatgt
     3541 ttttgaaaaa tatattcaaa tgtatggaat agcttgcttt gatagtgctc aatcatatca
     3601 tacttatcct tatagtgagt atagaagctg gaacgactaa ttccggcttt ttctactaat
     3661 ttgacagtag aaattttatc aaatggctgt tccatcagta attgtaccat agcattttca
     3721 atagttcgct ttgtttttaa gcgtttgtta ctttcttgca tatttcctcc ttgtaaacaa
     3781 attagactat atgtctaaaa atagattttt taatgtataa tctattatat caaaatttta
     3841 gacaatatgt ttaaaaaagg agaaactaag tttaaagaat ggaaagcaat ttaaaaaaaa
     3901 ccaaccttta ttattgtcat gatcgggatt tctcttattc cagatctgta caatatcata
     3961 tttttgtcat caatgtggga tccatatggg caattgtctg acttacctgt ggcagttgta
     4021 aataatgata aagaggcttc ctataatggt aatactatgg caataggaaa agacatggtg
     4081 tccaatttaa aagaaaataa aaccttggat tttcattttg tagatgaaga ggaaggaaag
     4141 aagggattgg aagatggcga ttactatatg gtagtgactt taccaagtga tttatctgaa
     4201 aaaacaacta cattatccaa tattcaatcg acagcagctt atcaatcatt gacaagtgag
     4261 caacaaactg agataagtga ttctgtatct caaaatttaa ctgatagtat tcaatcggct
     4321 cagtcaattg tagctttagt acaagattta cagggaagtt tagaaaactt acaaaatcaa
     4381 tctaatcaag tatcacctat tacttctact tctttgatag gattgtcaag tggattaaca
     4441 gagatacaag gagatgttac tagcaaatta gttcctgcca gtcagtcgat tgcatcaggt
     4501 gtaaacgcat atactacagg tgttgataaa gtttctcagg acgtcatcca gagagccgtt
     4561 gggcttggtt gaaatctcga gctgaaataa atggtattat agctgttttg gcaggaattt
     4621 tggtatatgg aggagttcat cttattggtt taactgctaa tcatgagatg agaatattta
     4681 ttctcatcat cctaacaagt ttagtattca tgtctatggt gaccacttta acaacgtgga
     4741 atagccgtat aggagctttc ttctcactta ttttgctttt actacagtta gcatcaagtg
     4801 caggtactta tccacttgct ttgacaaatg atttctttag atctattaat ccctggttac
     4861 caatgagcta ttcagtttcg ggattacgac aaacaatctc catcaacaag tcattttcct
     4921 agctgtcata ctagctctat ttactggttt aggtatgcta gcctatcaac ataagaaaat
     4981 ggaagaagat taaaaaaatc gaccgattaa ctggtcgatt ttttatgcct tagatgactt
     5041 tcgtctgtga ttatagattc caaatagtaa gagagaagta aaggaacaga ttgctccagt
     5101 aataaaacca ttgggaatga aggaaagtgt aatagttcct ttccccttgg gaatgtcaac
     5161 tttcataaat ccagtttgag cttgtttaat ttctattttc ttaccatctt ggtaggcaga
     5221 ccaacctttg tcataaggaa tggtgaagaa aatagatgta tcttgttgga catcatatgt
     5281 agcaaaaacc ttgtttttag aagttgatac tgtgacaggt tgttctttaa ttttttgaat
     5341 tgcctcggtg aaagttttgg tatctaaacg atagaaggta ggagattcaa atgatacttg
     5401 tgaatttcca gggaaactaa cattgatatt gaaagttttt ttctctttag tatatcctag
     5461 attaaagaag gagaagacat tatcagttgt aaaagtcttt ttttcaccat ttacaaggat
     5521 gtcaaccttc ttttgtttat cgttagaaaa gtgaaggttt atgaaagaga gataaacttg
     5581 gctgttttct ggaacttcaa tttgatactg gattgctgca tcttcatttg aagaacttgt
     5641 gacactaatc aaatcattag tattttctat tttttctgtt ttttcataag gtattggaga
     5701 aaaataatca aaattgacgt tagcaagttg atttaaaaat gaggcctgat tatccaaggt
     5761 atgttcattg aacttgacat cattgtaaac agattgacta gcaactgcaa tcggaagaga
     5821 gtattgattt tcatataggg taagattatc tttttgatag atatctttaa aaccatactt
     5881 atcaatagga ctgtctgaga tattgtactg gataccaaat aaactatcag ccaaaatact
     5941 attatttgca tatcggagat tgagattagt cccagaggat ttaaaaccaa gtttatctaa
     6001 agtagagctt gatgaacgat ttcgaacaga tgaaaattga gagattccat tgtagttgaa
     6061 tttcatactg tcatttcctg tctgagtttg tagtttttca gtacgagtaa attgatttcc
     6121 aatatatgtt gagaaagatt ccatagctgg gatatctcga ctataagcac ttcgagaagc
     6181 aaatccccat tccttagcaa ttccgtccat ttgagatgaa gcatttaaac tcatttcaac
     6241 cagtataaat aaagagatta gaatggcaaa tagattcaca gatataaact ttttgataac
     6301 tgcaaggagt aaaagagaat agacaaccaa aaattcaaga gtaagcagaa tattcaaatc
     6361 tgttaaaaaa gaataatgcg attttagata gatggtagct aaaaatcctg ctactacaag
     6421 aaaaagcgaa actaaaaaat tccagacttt aagttctttc agacgcttta agacttctgc
     6481 tgctgtgtaa attaacaagg tagagaaaat ccaagcatag cgatgtaaaa acatgtttgg
     6541 agtatgcatg ccttgccaaa ataagtcaag agcttctatg taaaagcttg caattagaaa
     6601 tgcaaagaat attacatata tgagtttcac gtgaaactta atagatttca gcgtaaaaaa
     6661 taaaatggtc aaaataaagg gaagtagtcc aacaaaaatc attgggatgg ccccatactt
     6721 tgttgtgtca aaggaaccaa tgaattgctt agcaaagaga tcaagatacc agctactttc
     6781 agtttgaaac tttgtaactt cagtcaattt ttccccatgt gtctgtaaat caaatagagt
     6841 gggaagagtc ataatcaaac tagccatacc agctaaaaag gagataacta tgaaatcaag
     6901 aacagatgat tttcgagtct taaagtccca cgaaatttga cagagatacc agaaaataag
     6961 aaacaatact gtcatatatc caaaataata attttgaata aataagattg acagacttgt
     7021 aaagtacaat aggagtttct tttcagttat cagtagatgt aaaccagtta taattaaagg
     7081 aatcaagata aaaacatcta gccaggtttt tatctctaat tgactgacag tgaaactcat
     7141 cagagcatag gaagtagata aggctagttt taaagtctga gggatagatt gaaacaattt
     7201 attcaaacta aaaaaggttg acagaccaat caatccaaat tttaagagag tggtcagata
     7261 gacagcatct ggcatattcg ttagatcaaa aaagtaaact agaggcgcga gaaaactacc
     7321 caagtaataa ctagataggg catagaagtt tagccctaga ccacttgtaa aggtgtaaaa
     7381 cagactacta tttccatgta ggatatttcg taaggctaca tcaaaaataa cgtattgatg
     7441 aaagccatct cctaatagag gagagttgtc gctattccag tagatacctt gagatagata
     7501 tactccagac ataatcacta caggaatgat gaaagaaata aaataggttc gatatgtttt
     7561 taaaaatgat ttcatgttac ctcgtagaat gatagaaaac tcagttggtt aacccaactg
     7621 agttttgaag ttttatttag tctttccaaa gttctttaac ttttgcttgt acttctgcat
     7681 tttctaggaa ttcatcgtag gtttcatcga tacggtcaat gacgccattt ttagataaga
     7741 caatgatatg gttagccaaa gtttgaataa actcgtggtc atggctggca aagatgattg
     7801 attctttaaa gtttttcaat ccatcattca agcttgagat agattccaag tccaagtgat
     7861 ttgttggatc atcaagtaca aggacatttg attttaagag catgagtttt gaaagcatga
     7921 cacgaacttt ttctccccct gacaagacat ttacaggttt gttaacttca tctccagaga
     7981 agagcatacg gccgaggaag ccacgtagga aagtattgtc atcttcttct ttacttgcga
     8041 attgacgcaa ccagtcaaga attgattctc ctcctgcaaa atcagctgag ttatcttttg
     8101 gtaggtaaga ttgactagtt gtaactcccc acttgacagt tccttcatag tcaatatctc
     8161 ccatgattgc acgaattaat gcagtcgttt gaatatcatt ttgtccaata agtgctgtct
     8221 tatcatctgg acgcaagatg aaactaatat tatccaagat agtttcacca tcaatcttta
     8281 cagttagatt ttctactgtc aagagatcat taccaatctc acgttccgct ttaaagttga
     8341 taaatggata tttacgacta gatggcacaa tctcttctag ctcaatctta tcaagcattt
     8401 tcttacgtga tgttgcctgc cttgacttag aagcattggc agagaaacga gcaacaaatt
     8461 cttgcaattg tttaattttt tcttctgctt tagcattacg gtctgctagc aatttagcag
     8521 caagctcaga agattccttc cagaagtcgt agtttccgac atagagtttg atttttccaa
     8581 agtcaaggtc ggccatgtga gtacaaactt tgtttaagaa gtgacggtcg tgggatacta
     8641 cgataactgt gttatcaaag tcaattaaga agtcttctaa ccaagtaatc gattggatat
     8701 ccaaaccgtt agtaggctcg tccaagagaa gaacatctgg tttaccaaaa agtgctttgg
     8761 cgaggagaac ctttactttt tcaccgttgg ccaattcgct catgttttgg tagtgtaatt
     8821 cttctggaat gtttaggttt tgaagtagtt gagaggcttc actctctgct tcccaacctc
     8881 caagttcggc aaactctcct tcgagttcgg cagcacgaac cccgtcctcg tctgagaaat
     8941 cttccttcat gtagatagca tctttctctt tcatgatgct ataaagtttt tcatttccca
     9001 tgataacgac atcaatggca cgttcatctt cgtagtcaaa gtgattttga cgaagaacag
     9061 agagacgttc atctggacca agagagatgt gaccagtagt aggttcgata tctccagcta
     9121 aaatttttaa aaaggttgat tttccggcac cattagcacc gattaatccg taagtatttc
     9181 cttctgtaaa tttgatattg acatcatcaa aaagtttgcg atcactaaaa cgtagtgaaa
     9241 catcagatac tgtaagcaat atttttctcc tatatgtgta atatatttat tctactagaa
     9301 aatacagaaa tattcaaatt tttatttgtc aattttgtgt aaattatatt tacagtatcc
     9361 tttacacaaa tctgtaaaaa gcaaggctga tttattttga taaattacgg ttatttcatt
     9421 aaaaaaatgc tataattgaa aggactatat cgaaggagaa caaaatgact aaacccatta
     9481 ttttaacagg agaccgtcca acaggaaaat tgcatattgg acattatgtt ggaagtctca
     9541 aaaatcgagt attattacag gaagaggata agtatgatat gtttgtgttc ttggctgacc
     9601 aacaagcttt gacagatcat gccaaagatc ctcaaaccat tgtagagtct atcggaaatg
     9661 tggctttgga ttatcttgca gttggattgg atccaaataa gtcaactatt tttattcaaa
     9721 gccagattcc agagttggct gagttgtcta tgtattatat gaatctagtt tcgttagcac
     9781 gtttggagcg aaatccaaca gtcaagacag agatttctca gaaaggattt ggagaaagca
     9841 ttccgacagg attcttggtc tatccaatcg ctcaagcagc tgatatcaca gctttcaagg
     9901 ctaattatgt tcctgttggg acagatcaga aaccaatgat tgagcaaact cgtgaaattg
     9961 ttcgttcttt taacaatgca tataactgtg atgtcttggt agagccggaa ggtatttatc
    10021 cagaaaatga gagagcaggg cgtttgcctg gtttagatgg aaatgctaaa atgtctaaat
    10081 cactaaataa tggtatttat ttagctgatg atgcggatac tttgcgtaaa aaagtaatga
    10141 gtatgtatac agatccagat catatccgcg ttgaggatcc aggtaagatt gagggaaata
    10201 tggttttcca ttatctagat gtttttggtc gtccagaaga tgctcaagaa attgctgata
    10261 tgaaagaacg ttatcaacga ggtggtcttg gtgatgtgaa gaccaagcgt tatctacttg
    10321 aaatattaga acgtgaactg ggtcctattc gtgagcgccg tattgaattt gctaaggata
    10381 tgggagaagt ttataatatg attcaaaaag gtagtgaaag agcgcgtgaa gttgcgggtc
    10441 aaaccctatc tgaggtaaaa ggggcaatgg gacttcatta ctttaactaa gtttatttta
    10501 caagaaacta tcatttctat ctcgaagaaa agatagtttt ttatttaccc ctgtaacatt
    10561 tgacaaattt ttatagaatg gtatgataga tacaatataa aaagagtcaa gctcaaaaag
    10621 aaagaaaaga ggaaacttcg aatgtctaat tgggacacta aatttttgaa aaaaggtttt
    10681 acctttgatg atgtattgct tattccagct gaaagtcatg tgttgcctaa cgatgcagat
    10741 ttaacaacta aattggcaga taatttgact ttaaatatcc caattattac cgctgccatg
    10801 gacacagtta cagagagtca aatggccatt gctattgctc gtgcaggtgg tctcggagtt
    10861 atccataaaa acatgtcaat tgctcaacaa gcagacgagg ttcgtaaggt aaaacgttct
    10921 gaaaatggag ttattattga tccgttcttc ttgacgcctg aacatacaat tgctgaagca
    10981 gatgagctta tgggtcgtta ccgcatcagt ggtgttccag ttgttgaaac acttgaaaat
    11041 cgtaaattgg ttggtatttt gacaaaccga gatcttcgtt ttatttcaga ttataatcaa
    11101 ccaatttcaa accatatgac tagtgaaaat cttgttactg ctcctgtggg tacggatctt
    11161 gcaacggctg agagtattct tcaagagcat cgtattgaaa aacttccgtt ggtcgatgaa
    11221 gaaggcagtc tttctggttt gatcactatc aaagatattg aaaaagttat tgagtttcca
    11281 aatgcggcta aagatgaatt tggtcgtctt ctagttgcag gtgcagtagg tgttacttca
    11341 gatacatttg aacgtgcaga ggctcttttt gaggcaggag cggatgcgat tgttattgat
    11401 actgcacatg gtcattctgc aggtgtcttg cgtaaaattg ccgagattcg tgctcatttc
    11461 ccagatcgga ctttgattgc tggaaatatt gctactgctg aaggtgcacg tgccctttat
    11521 gaagcgggtg tagacgttgt taaggttggt attggaccag gttctatctg tactactcgt
    11581 gtgattgctg gtgttggtgt tccgcaagta acagctatct acgatgctgc agctgttgcg
    11641 cgcgaatatg gtaaaacgat tattgctgac ggtgggatca agtattctgg agatattgta
    11701 aaagcacttg ctgcaggtgg aaatgctgtt atgcttggat ctatgtttgc tggaactgat
    11761 gaagctccag gcgaaactga aatcttccaa ggacgtaaat tcaagactta ccgtggtatg
    11821 ggatcaattg ctgctatgaa gaaaggttca agcgaccgtt atttccaagg ttctgtcaat
    11881 gaagcaaaca agctcgttcc agaaggaatt gaaggtcgtg ttgcttataa aggagcggca
    11941 gctgatattg ttttccaaat gattggtggt attcgctctg gtatgggtta ctgtggtgca
    12001 gctaacctta aagaactaca cgataatgct caatttattg aaatgtctgg tgctggtttg
    12061 aaagaaagcc atcctcatga tgtgcaaatt actaatgagg caccaaatta ttctatgtaa
    12121 aaaacaatga aaagaactcc agtgaaaaca ggagttcttt tacaatgttg tcaatttcca
    12181 tttacagaag ctttaccatc ctgaatagtg aagatactta gattttctgg cagattttga
    12241 agatggtcta agcttgttgt tgtgataaag gtttggattg attgagaaat cgtttctaat
    12301 aattttaact gtctagtgtt gtcaagttca ctcatcacat cgtcaagcag taatatagga
    12361 gattctgtgg taatgctttc cattaattcg atttctgcta attttatcga gaggacgaga
    12421 ctacgatgtt gaccttggct tccgaaacta gcatccatcc catttatata aaaagaaatg
    12481 tcatctcgat gaggaccgac accagtattc tttttaaata aatctctgga tctacttttt
    12541 tctaaagcaa ttttgaaaga ttcggataag ttttgtttgt cagttatatt gacagaagat
    12601 tgataggata ttgacaactc ttcgatctga ttagagagtt caaaatgttt cttacgccca
    12661 aatgattcta gtttttttat gaaatctaag cggtgattca ttacacgaca tccataatca
    12721 actagctgat catctaacac agaaaggaat gtttcatcta ttttttgagc tgattttagg
    12781 taagtgtttc tttgctttag gatgtggtta taattggtta agtcagataa atagattggc
    12841 ttaatttgcc caagttccat atcaatgaat tttcgtcgaa tcgaaggtgc tcctttaatt
    12901 agttgtaaat cttcaggagc aaataagaca acattcatgt gtcctacata atctgaaagg
    12961 cgtgcctgtt ttaagtgatt aacttttgtt acacggcctt tttgtgttag ttcgatttct
    13021 aggggaatgg atccagtttt tttctgaacg agacctgaaa gatgaagttg ttcctcatca
    13081 aaatgaatga gatttttatc tgttcgagtt cgatgactac gcgttaaggc taaaaaatag
    13141 atagcctcta acatgtttgt ttttccttgt gcattacgtc ccaaaaagac attcaattta
    13201 ggattaaagt ctattttcgt ttctttgtaa ttacgaaaag tcttgagaga tagatgttgt
    13261 agccacatga ttatctacca gggaatcgtg gagcttgttg gcttttaggt gatgaagcag
    13321 gtttcgattt gtctttttta actcccttat tcatcttttt gacaagttta gcgatccgtt
    13381 ctttttcaac tttatcagct tggtattcat cttgttcttc agaagtaggt tgtgtcaaca
    13441 agatgtcaat gttcatgtca gggatgtcaa ctttatcgcc aatacgaagt ttttttccac
    13501 gacgactctc taattcccta ttaaagtaaa cagaatgttc agagagaaat gatttaatag
    13561 ctcctccgct atgtgtaatt ccaagttctt tgagtagtgc ttggagggta ataaattctt
    13621 caaataattt gtattccata attcacctca atctttggta ttataccata ttttcctaaa
    13681 aatagtgaga gagacagcga gaaatgtaag cgatttttat ttcaaaagtg ttacagggaa
    13741 caagaaaatt tcaggttttc gtgatataat agaagtctgt atataaggag gtaaatcatg
    13801 gagttagtgc atggaatttc aacacatttt atccaatcaa aaaagtttaa aacaaacaaa
    13861 attaccgtgc gttttaccgc tccattagcc cttgatacga ttgcaggtca catgttgagt
    13921 gcaagtatgc tagagactgc taatcagatg taccccactt ctcaagattt gaggagacac
    13981 ttggccagtc tatacggtac agatatgtca accaattgtt tcagaagagg gcaaagccac
    14041 attatagaat tgacatttac ctatgttcgt gatgagtttt taagtaggaa aaacgtgcta
    14101 acctctcaga ttttggaact tgtaaaagaa actctttttt cacccgtagt agttgataat
    14161 gggtttgatc cggccttatt tgaaattgag aaaaaacaat tgctagcaag tttagcagct
    14221 gatatggatg attcttttta ttttgcacat aaagaattgg ataaattgtt ttttcatgat
    14281 gaacgtcttc aattggaata tagtgattta cgaaatcgta ttttagatga aactccacaa
    14341 agttcttatt cttgtttcca agaattttta gccaatgatc gaatagattt ctttttccta
    14401 ggtgatttta atgaggttga aattcaaaat gtattagaat catttggctt taaaggtcga
    14461 aaaggagatg tgaaggttca gtattgtcaa ccttattcta atatccttca ggaaggtatg
    14521 gttcggaaaa atgtgggaca atctattttg gaattaggtt atcattaccg ttctaaatat
    14581 ggtgatgagc aacatttacc catgattgta atgaatggtt tacttggtgg atttgctcac
    14641 tctaagctct ttacaaatgt ccgtgaaaat gctggattag cttataccat ttcaagtgag
    14701 cttgatttat ttagtggatt cttgaggatg tatgctggta tcaatcgaga aaatcgtaac
    14761 caggctcgta aaatgatgaa taatcaactg cttgatttaa aaaaaggtta ttttacagag
    14821 tttgagttaa atcagaccaa ggaaatgatt cgttggtcgt tgttactttc tcaagataat
    14881 caatcttcat tgattgaacg tacttatcaa aatgccttat ttggaaaatc ttcagcagac
    14941 tttaaaagtt ggattgcaaa gcttgaacaa attgacaaag atgctatttg tagagtagct
    15001 aataatgtga aactacaagc gatttacttt atggaaggaa tagaatgaca aaggttgttt
    15061 ttgaagaaaa atactatcca gctgtaaaag aaaaggttta tcgaactcgt ttggccaacg
    15121 gattgacagt tgctcttttg cctaaaaagg aatttaaaga ggtttacggg agtgtcactg
    15181 tacagtttgg ttcggtagat acgtttgtca cagaagttga cggagatgta aaacaatatc
    15241 ctggaggaat tgctcatttt cttgaacata aattatttga gagagaagat tctagtgatt
    15301 tgatgtcggc ttttacgagt ctaggtgcag atagtaatgc ctttacaagc tttacaaaaa
    15361 caaactatct tttttcagca acggattatt ttttagaaaa tttatattta cttgatgaat
    15421 tggtaacatc agcacacttt actgaagctt ccattctgac agagcaggat attattcagc
    15481 aagaacgaga aatgtaccaa gatgatccag attcgtgttt attcttttca actttagcga
    15541 atttgtatcc tggtacacct ttagcaactg atatagttgg aagtgaggag tccatttccc
    15601 aaatcaatct aactaatttg caagaaaatt ttacaaagtt ttacaaacct gtaaacatgt
    15661 ctctgttttt agttggtaat tttgatgtgg agcgagtaca ggactatttt gaaagcaaag
    15721 aactgaaaga ttcagatttt caggaagtag caagagaaaa gttgttttta cagcctgtaa
    15781 agccaacaga tagtatgaga atggaagtat cttctcccaa actagcgatt ggagttagag
    15841 gtaagcgaga agtttctgaa gcggattgct atcgacatca tattttatta aaattattgt
    15901 ttgcaatgat gtttggttgg acttcggatc gttttcaaaa atgttatgaa tcaggtaaaa
    15961 ttgatgcatc cttatctctg gaagttgaag taacaagtcg ctttcatttt gtcatgttga
    16021 caatggatac gaaagagcca gttgctttgt ctcatcaatt taggaaggct attcgtaatt
    16081 ttacaaagga tttagatatt acagaggaac atttagatat tatcaaaaga gagatgtttg
    16141 gcgaattttt cagtagcatg aactctcttg aatttattgc aacgcaatat gatgcttttg
    16201 aaaatggtga gacaattttt gatttgccga aaattttaca ggaaattact ttagaggatg
    16261 tccttgatgc tggacatcat ttaatagatg atggtgacat agttgatttt acaatattcc
    16321 catcgtagta acctattata atagacacta gaaagaaggg atgacaagta tgagaaaaaa
    16381 aacaattgga gaggttttac gattagctag aatcaatcag ggattgagtt tagatgaatt
    16441 gcagaaaaag acagaaatcc agttagatat gttggaagca atggaagcag acgatttcga
    16501 tcaacttcca agtccttttt acacgcgttc tttcttgaaa aaatatgcat gggctgttga
    16561 gttagatgac caaattgttt tggatgctta tgattctggg agtatgatta cttatgagga
    16621 agtagatgtt gatgaagatg agttgacagg tcgtagacgt tcaagtaaga aaaagaagaa
    16681 aaaaacatca tttttacctt tattttattt tatccttttt gctttatcga ttttaatttt
    16741 tgtgacttat tatgtttgga actatattca aactcaacca gaggagcctt ctctttctaa
    16801 ttacagtgtg gttcaatcaa caagttcaac tagctctgtt ccccactcct caagtagtag
    16861 ttcttctagt atagaatcag ctataagtgt atcaggcgaa ggaaatcatg tagaaatcgc
    16921 ttataagaca agtaaggaaa cagttaaatt gcaattggca gtttcagatg ttacaagttg
    16981 ggtcagtgtt tcagaaagcg aacttgaggg cggtgtaacc ttatcgccaa agaagaaaag
    17041 tgcagaagca acagttgcaa ctaaaagtcc tgtaacaatt acgttaggtg ttgtaaaagg
    17101 tgttgatttg acagtagata atcagactgt tgatttatcg aaattaacag ctcagactgg
    17161 acaaattact gtaaccttta ctaaaaatta aggaaaaacg aatgaaaaaa gaacaaattc
    17221 ccaatctctt aacaataggt cgaattctct ttatacctat ttttatcttt attttaacga
    17281 taggaaattc gatagagagt catatagttg cagctattat ctttgctgtt gccagtatta
    17341 ccgactattt agatggatat ttagctcgta aatggaatgt ggtcagtaat tttggtaaat
    17401 ttgcagatcc tatggcggat aagttactag ttatgtcggc ttttattgtg ttgattgagt
    17461 taggtatggc tccggcttgg attgttgcag tgattatctg tcgtgagtta gctgtgacag
    17521 gtttaaggct tttattggtt gaaactggtg gaacaatttt agcagcagca atgcctggaa
    17581 aaattaaaac ttttagtcag atgtttgcca ttattttctt gctattacat tggactttgc
    17641 ttggtcaagt tctactttat gtagccttat ttttcactat ctactctggc tatgactatt
    17701 tcaagggtag tgcctatgta tttaaaggga catttggttc gaaatgaaat caataattga
    17761 tgtaaaaaat ctttcttttc gctataaaga aaatcagaac tactacgatg tgaaggatat
    17821 tacgtttcac gtgaaacgtg gagaatggct ttcgattgta gggcataatg gtagtggtaa
    17881 atcaacgacg gttcgattaa ttgatggctt actggaagca gaatccggag agattgtaat
    17941 tgatggccaa cgtttgactg aggaaaatgt ttggaatata cgtcgtcaaa tcggtatggt
    18001 ttttcaaaat ccagacaatc aatttgttgg agcgactgtt gaagatgatg ttgcttttgg
    18061 tttggaaaat cagggacttt ctcgtcaaga aatgaaaaag agagtagaag aagctctggc
    18121 tttagttggc atgttggact ttaaaaagag agagccagcg cgtctatcag gtggccaaaa
    18181 gcaacgtgtg gccattgcag gtgttgtagc cctaagacca gctattttaa tcttagatga
    18241 agcaacgagt atgttggatc ctgaggggcg tagagaactt attgggacag taaaaggaat
    18301 tcgaaaagac tatgatatga cggtcatttc tattacccat gatttggaag aagtcgccat
    18361 gagtgatcgc gtattggtca tgaaaaaagg ggaaattgaa tcaactagta gtccaaggga
    18421 gcttttctct cgaaatgatt tagatcaaat tggattagac gatccttttg ctaatcaatt
    18481 aaaaaaatct ttgagccaga atggctatga tttacctgaa aattatttga cagaaagtga
    18541 gctagaggat aagctatggg aattgctcta gaaaatgtga attttacata tcaagaaggt
    18601 actcccttag cttcagcagc tttgtcggat gtttctttga cgattgaaga tggctcttat
    18661 acagctttaa ttgggcacac aggtagtggt aaatcaacta ttttacaact cttaaatggt
    18721 ttattggtgc caagtcaagg gagtgtgagg gtttttgata ccttaatcac ctcgacttct
    18781 aaaaataaag atattcgtca aattagaaaa caggttggct tggtatttca gtttgctgaa
    18841 aatcagattt ttgaagaaac ggttttgaag gacgttgctt ttggaccgca aaattttgga
    18901 gtttctgaag aagatgctgt gaagactgcg cgtgagaaac tggctctggt tggaattgat
    18961 gaatcacttt ttgatcgtag tccgtttgag ctgtcagggg gacaaatgag acgtgttgcc
    19021 attgcaggca tacttgccat ggagccagct atattagtct tagatgagcc aacagctggt
    19081 ctagatcctc tagggagaaa agagttgatg accctgttca aaaaactcca ccagtcaggg
    19141 atgaccatcg tcttggtaac gcatttgatg gatgatgttg ctgaatatgc aaatcaagtc
    19201 tatgtaatgg aaaagggacg tttagtaaag gggggcaaac caagtgatgt ctttcaagac
    19261 gttgttttta tggaagaagt tcagttggga gtacctaaaa ttacggcctt ttgtaaacga
    19321 ttggctgata gaggcgtgtc atttaaacga ttaccgatta agatagagga gtttaaggag
    19381 tcgctaaatg gatagtatga ttttagggcg ttatatccca ggggattcga ttgttcaccg
    19441 attggatcca cgtagcaaat tgcttgctat gatgctactg attttgattg tgttttgggc
    19501 taataacccc ttgacgaatc tgattctttt tatagcgaca gggatattta ttgccttgtc
    19561 aggagtatct ctttcatttt ttattcaggg cttgaagtct atgtttttct tgattgcctt
    19621 cacaactatt tttcaactat ttttcatttc taatgggaat gttttatttg agttttcgtt
    19681 tgtgagaatc acggattatg ctttgcaaca agctgggatt attttttgtc gctttgtatt
    19741 gattattttc ttttcaactt tgttaacctt aacaaccatg cctttaagtt tggcatcagc
    19801 tgtcgaagct ttattagcac ctttaaagcg tgtgaaagtt ccagttcatg aaattggatt
    19861 gatgctgtct atgagtttgc gttttgtccc aaccttgatg gatgatacga cgcggattat
    19921 gaatgcacag aaagctcgtg gagtggattt tggagaagga agcatcgttc aaaaagtaaa
    19981 ggcgatgatt cccattttga ttcctctttt tgcgacaagt ttaaaacgtg cagattcctt
    20041 ggctatcgct atggaagcgc gtggctatca gggtggaaaa ggcagaagtc aataccgaca
    20101 attgaaatgg actctaaagg atacgctgac cattcttgtt attctcgtac ttggttgttg
    20161 tttatttttc ttaaaatctt agtagctttc aggaattgat aaaaagttac tgtaacagtt
    20221 tttgatataa aggtagggat atgaaccgtt ttaaaaaatc aaaatatgtc attattgttt
    20281 ttgtcactgt tctgcttgtg tcagctctct tagcgacgac ttattcaagt acaattgtga
    20341 caaaattagg agatggaatc tcattggttg atagagttgt acaaaaacct tttcagtggt
    20401 ttgattctgt caaatcagat ttggctcatt tgacacgaac atataatgaa aatgaaagtt
    20461 tgaagaaaca gctttaccaa ttagaagtta aatcaaatga ggtggaaagt ttaaagacag
    20521 aaaatgaaca actgcgccaa ttgcttgata tgaagtctaa attgcaagcc acaaagactt
    20581 tagcagcaga tgttattatg cgttctccgg tatcttggaa gcaggagttg accttagatg
    20641 caggtagatc aaaaggtgct tctgagaaca tgttagctat tgcaaatggt ggcttgattg
    20701 ggagtgtttc aaaagtagag gagaactcta ctatagtcaa ccttctgaca aatacggaaa
    20761 atgctgataa gatttctgtt aaaattcaac atggctctac tacaatttat ggaattatta
    20821 ttggctatga caaggaaaat gacgttctta aaattagcca attaaatagt aatagcgata
    20881 ttagtgcggg agataaggtg actactggtg gattaggaaa ctttaacgtt gctgatattc
    20941 ctgttggtga agtggttgcc acaacgcata gtacagacta tttgacacga gaagtaactg
    21001 ttaaattgag tgcagatact cataatgtag atgtgataga attagtgggg aattcataat
    21061 gagacagttg aagcgagttg gagtattttt attgcttcct ttctttgttc taattgacgc
    21121 ccatattagc cagcttctgg gctcattttt cccccatgta catttggcta gtcattttct
    21181 ttttctattt ctcttatttg agacgataga agtatcagag tatctctacc tagtctattg
    21241 ttttgttata ggcttggttt atgatgttta ctttttccat ctaataggga ttacaactct
    21301 cttatttatc ttattgggag ccttccttca taaattgaat agtgttattt tgttgaatcg
    21361 ttggacaaga atgctagcta tgattgtgct gacattcctg tttgaaatgg gtagttatct
    21421 tttggctttt atggtagggt tgacagtaga tagcatgtcg atttttatag tctatagctt
    21481 ggtaccgacg atgattttaa attttttatg gattactgtt tttcaattta tttttgaaaa
    21541 atattatcta taagaacgac atataaatgt aacaaaggcg taatatttat taggcctttt
    21601 tttggtatac tagtattgtc tttaaaagaa ggagtatcta cgtaatatga agaaaaaaat
    21661 cttagcgtca cttttattaa gtacagtaat ggtttctcaa gtagctgttt taacaactgc
    21721 gcatgcagaa acgactgatg acaaaattgc tgctcaagat aataaaatta gtaacttaac
    21781 agcacaacaa caagaagccc aaaaacaagt tgatcaaatt caggagcaag tatcagctat
    21841 tcaagctgag cagtctaact tgcaagctga aaatgataga ttacaagcag aatctaagaa
    21901 actcgagggt gagattacag aactttctaa gaacattgtt tctcgtaacc aatcgttgga
    21961 aaaacaagct cgtagtgctc aaacaaatgg agccgtaact agctatatca ataccattgt
    22021 aaactcaaaa tcaattacag aagctatttc acgtgttgct gcaatgagtg aaatcgtatc
    22081 tgcaaacaac aaaatgttag aacaacaaaa ggcagataaa aaagctattt ctgaaaaaca
    22141 agtagcaaat aatgatgcta tcaatactgt aattgctaat caacaaaaat tggctgatga
    22201 tgctcaagca ttgactacga aacaggcaga actaaaagct gctgaattaa gtcttgctgc
    22261 tgagaaagcg acagctgaag gggaaaaagc aagtctatta gagcaaaaag cagcagctga
    22321 ggcagaggct cgtgcagctg cggtagcaga agcagcttat aaagaaaaac gagctagcca
    22381 acaacaatca gtacttgctt cagcaaacac taacttaaca gctcaagtgc aagcagtatc
    22441 tgaatctgca gcagcacctg tccgtgcaaa agttcgtcca acatacagta caaacgcttc
    22501 aagttatcca attggagaat gtacatgggg agtaaaaaca ttggcacctt gggctggaga
    22561 ctactggggt aatggagcac agtgggctac aagtgcagca gcagcaggtt tccgtacagg
    22621 ttcaacacct caagttggag caattgcatg ttggaatgat ggtggatatg gtcacgtagc
    22681 ggttgttaca gctgttgaat caacaacacg tatccaagta tcagaatcaa attatgcagg
    22741 taatcgtaca attggaaatc accgtggatg gttcaatcca acaacaactt ctgaaggttt
    22801 tgttacatat atttatgcag attaatttac agagggactc gaatagagcc ctcttttcag
    22861 gttttaccgt gacaatccct attaaaaatt atatcaaaat agcttgaaaa tattggaaaa
    22921 gtatggtaga atgaaaattg tcgtgtgaac gataatactc attcttgatg aattgtgaag
    22981 cagttgccct tgggtcgttt tgcgagttga agtcaagaag aggaaaaaaa caaaaaggag
    23041 aaatactcat ggcagtaatt tcaatgaaac aacttcttga ggctggtgta cactttggtc
    23101 accaaactcg tcgctggaat cctaagatgg ctaagtacat ctttactgaa cgtaacggaa
    23161 tccacgttat cgacttgcaa caaactgtaa aatacgctga ccaagcatac gacttcatgc
    23221 gtgatgcagc agctaacgat gcagttgtat tgttcgttgg tactaagaaa caagcagctg
    23281 atgcagttgc tgaagaagca gtacgttcag gtcaatactt catcaaccac cgttggttgg
    23341 gtggaactct tacaaactgg ggaacaatcc aaaaacgtat cgctcgtttg aaagaaatta
    23401 aacgtatgga agaagatgga actttcgaag ttcttcctaa gaaagaagtt gcacttctta
    23461 acaaacaacg tgcgcgtctt gaaaaattct tgggcggtat cgaagatatg cctcgtatcc
    23521 cagatgtgat gtacgtagtt gacccacata aagagcaaat cgctgttaaa gaagctaaaa
    23581 aattgggaat cccagttgta gcgatggttg acaccaatac tgatccagat gatatcgatg
    23641 taatcatccc agctaacgat gacgctatcc gtgctgttaa attgatcaca gctaaattgg
    23701 ctgacgctat tatcgaagga cgtcaaggtg aggatgcagt agcagttgaa gcagaatttg
    23761 cagcttcaga aactcaagca gattcaattg aagaaatcgt tgaagttgta gaaggtgaca
    23821 acgcttaatt tatacaaata gtaattacct aggagggcgg ggcttagccc ggctctccta
    23881 ttttcaaaaa atataggaga attaaaatgg cagaaattac agctaaactt gtaaaagagt
    23941 tgcgtgaaaa atctggtgcc ggtgttatgg acgctaaaaa agcgcttgta gaaacagacg
    24001 gtgacatcga aaaagcgatt gaattgcttc gtgaaaaagg tatggctaag gcagctaaga
    24061 aagctgaccg tgttgctgca gaaggtttga ctggtgttta tgttaacggt aatgttgcag
    24121 cagttattga agtaaacgct gaaactgact tcgttgcaaa aaacgctcaa ttcgttgaat
    24181 tggtaaatac tacagctaaa gtcattgctg aaggaaaacc tgctaacaat gaagaagctc
    24241 ttgctttgat aatgccttca ggtgaaactc ttgaagctgc atacgtatct gcaacagcaa
    24301 ctatcggaga gaaaatctca ttccgtcgct ttgcattgat tgaaaaaaca gacgcacaac
    24361 actttggagc ataccaacat aacggtggac gtatcggtgt tatttcagtt gttgaaggtg
    24421 gagacgaagc acttgctaaa caattgtcaa tgcacatcgc agcgatgaaa ccaacagttc
    24481 tttcttacaa agaattggat gagcaattcg ttaaagatga gttggcacaa ttgaatcacg
    24541 ttatcgacca agacaacgaa agccgtgcaa tggttaataa gccagctctt ccacacttga
    24601 agtatggatc aaaagctcaa ttaactgatg atgttattgc tcaagctgaa gctgacatca
    24661 aagctgaatt ggctgcagaa ggcaaaccag aaaaaatctg ggacaaaatt attccaggta
    24721 aaatggatcg cttcatgctt gataacacta aagttgacca agcttacaca cttcttgcac
    24781 aagtttacat catggatgac agcaagacag ttgaagcata ccttgaatca gttaacgctt
    24841 cggtagttga gtttgctcgc tttgaagttg gtgaaggtat cgagaaagct gcaaacgact
    24901 tcgaagctga agttgcagct acaatggcag cagccttgaa taactaataa tagaaaggaa
    24961 gcaatttgct tccttttttg tatagggctt atatttttcc tgaaattgtt tttcccccag
    25021 tctcactcga ttagaataat taaaacaaaa agccctataa taagggctaa gtgcatttag
    25081 gagactatac ttcaaattca tagtaagcgc gtcataacaa ggtatctatc ctaattcccc
    25141 aacttccagt atactagata aaaaataatt atcggaggaa aggtattgta ctatgatgat
    25201 tcaactaagt gatttaggtc aagttcacat tgtttgtggc aagacagata tgaggcaggg
    25261 aatagactca ttagcctatg tagttaaaac ccactttgaa ttggattctt tctccggtca
    25321 agtctttctc ttttgtggtg gacgtaaaga ccgctttaaa gtcctttact gggatggtca
    25381 aggattttgg ctactatata aacgctttga gaacggaaaa ctgacttggc taagtacaga
    25441 aaaggatgtc aaagctctca catctgaaca agtagactgg cttatgaagg gcttttctat
    25501 cactccccaa atatagtggt ttgaaactag aatagtacac ctctgcttct aaaacattgt
    25561 tagaaatcga tttgactgtc ctgttcttat ttcattttac tataaattca tcagaaagtc
    25621 gtgatttcta ttgaaatgag gactttcttt ttatactcat ctgttttcac aaagcattct
    25681 agtccatctc cgattaacga tggactttat cacctccttc tccagtcctt gtataacatc
    25741 ttggagttga ttcatgacat cttccaaaat ttgaaaggct ttattcttaa atccacgttt
    25801 acgaatctct ttccacactt gttcaatggg gttcatctct ggtgtgtatg gaggaataaa
    25861 tgcaaagcca atattagtcg gaatctttaa ggtacttgat ttatgccata tagcattgtc
    25921 cataacgagt aaaagataat catctggata agcttgtgaa atctcctatt cctaaagccc
    25981 ctttagcgca taactttggc tcagcttcta ttatcgctca caccatccat cagaagttta
    26041 atctgaaggt acccaattat cgccaagaag aagattgggc taggatgggt ttaccaatca
    26101 cacgtaagga aatctctaat cggcatatca agacgagtca atactatttg gagccccttt
    26161 ataacctctt gcgagagaga ctattgactc agcccttact tcatgcggat gaaacttctt
    26221 atagggtgct agagagtgat agtcagctga cttactattg gacttttttg tctgggaaag
    26281 ctgagaaaca agggattacg ctttaccatc atgtcctaat cgatttgttc atatcttatt
    26341 tcaatccatt ataaatagtg agaaatatct atcctatctt ctagaatgtc ttccaaacgt
    26401 ggaaactctc gtaaacaaag aggttttaga ggcctattta ccatggacta aagttgtaca
    26461 agaaaagtgc aaataagaaa tctccagatt aggaactatc cgtgagttct ctagtctgga
    26521 gatttttcaa tagacttcgt tattggacgg ttacaattca taaagtgctg tagagagata
    26581 acgttcaccg ttatctggtg ctagggcaag gactttttta cctgtaccta attttttggc
    26641 aacctcgatg gctccgtaga tagctgcagc tgaggaaatc cctacaagga agccttcttt
    26701 tccaccaatt tcacgtccga gtgcaagagc gtcatctgat gttacacgaa cgataccatc
    26761 ataggcttta gtatcaagtg tatcaggaat aaatccagct gagatacctt gaattttgtg
    26821 aggaccaggt ttttcaccag atagaatagc agattcatct gcttctactg caaaaacttg
    26881 aatgttagaa ttttctgatt tgagtgcatg agaaacacca gaaatcgttc caccagtacc
    26941 tactccagca acaaaggcat ctaatccatc tttaccgaaa gcagctagta tctcagctcc
    27001 tgttgttctt tcgtgtactt ctggattagc tggattgtca aattgaagag gaaggaaacc
    27061 atcacgttca gcagcgattt cttgagcctt agcaatagca cctttcattc cctcgctacc
    27121 aggagttagg acgagttcag caccataagc ttggataatt ttacgtcgtt ctacactcat
    27181 agtttcaggc ataacgatga cgactttata ccctttagca gcacctaccc atgaaagtcc
    27241 aataccggtg tttccacttg ttgcttcaac aatagtagaa ccaagtttca gaataccatc
    27301 ttgttcagct ttttcaatca tgctaagggc aatacggtct tttacagatg aaccaggatt
    27361 aaatgcttca agctttatat agacgtctgc agcaccttct ggcacgatgt tgttaagttt
    27421 aacaatcggt gtttgaccga ttaattcagt aatgttgtta taaatagaca tatgaatacc
    27481 tctttgtata agatatcttt agtataacgc tatccatacc atttgtaaaa tatagaaatc
    27541 ctatcgaagc gataggattt ctatatatca tagatcaaag tcattaattt tcaagtgatt
    27601 gcgttcagtt aattctagta aataggtgtg aaggaaaacg atatcaggtt tcgtttgaat
    27661 tgcttcattt tctagtatat tttggtacgc atctttttat tttgctcgct aaagtagttg
    27721 tgagaatgtc aacgaaacgc tgtattattc attgtttaca ctaagtttac aggaacttca
    27781 acctctcgta aaccttggtc agttaaagtg acttttccat taaaaaactc cacaagtgca
    27841 gctttaatag tttctttttc ttctttatca acataaatca tcgtatcgac ttgatctgta
    27901 aagtttgtat ccagctccat gagatcatgt tctttaagga agttactgta ctcttggtac
    27961 tgagcataag acatttgaat agcaatgcca gcctgttctt ttatttcaat aataccaatt
    28021 tctttgacag ctaaggcgac actgctggtg taagcacgaa ttagtcctcc agcgcctagt
    28081 ttaataccac caaagtagcg tgtcacgacc acacagacat tggtgagatt gtgattttct
    28141 agtaccccaa gcatgggaac accagcagta ccactaggct caccatcatc acttgtacgt
    28201 ttaatttcac tacgttctcc aataataaag gcagagcagt tatgtgtcgc tttgtagtgt
    28261 tcttttttga tggcagtaat gaagtcacga gcctcttctt cgctataaac acgcttggca
    28321 tggcagataa agcgagattt tttgatttct tcttggactt ggccgtcctc tttaattgtc
    28381 ctaaattcca tgatttaatt gtactaaaaa atcatctaaa gtgctagttt ttacgaataa
    28441 agaagtatga aagtaaattt agattatctc ggtcgtttat ttactgagaa tgaattaaca
    28501 gaagaagaac gtcagttggc ggagaaactt ccagcaatga gaaaggagaa ggggaaactt
    28561 ttctgtcaac gttgtaatag tactattcta gaagaatggt atttgcccat cggtgcttac
    28621 tattgtcgag agtgcttgct gatgaagcga gtcagaagtg atcaaacttt atactatttt
    28681 ccgcaggagg attttccgaa gcaagatgtt ctcaaatggc gcggccaatt aactcctttt
    28741 caagagaagg tgtcagaggg actgcttcaa gcagtagaca agcaaaagcc aaccttagtt
    28801 catgcggtaa caggagctgg aaagacagaa atgatttatc aagtagtggc taaagtgatc
    28861 aatgcgggtg gtgcagtgtg tttggctagt cctcgcatag atgtttgttt ggagctgtac
    28921 aagcgcctgc aacaggattt ttcttgcggg atagctttgc tacatggaga atcggaacct
    28981 tattttcgaa caccactagt tgttgcaaca acccatcagt tattgaagtt ttatcaagct
    29041 tttgatttgc tgatagtgga tgaagtagat gcttttcctt atgttgataa tcccacgctt
    29101 taccatgctg tcaagaatag tgtaaaggag aatggattga gaatcttttt aacagcgact
    29161 tcgaccaatg agttagataa aaaggtccgt ttaggagaac taaaaagact gaatttaccg
    29221 agacggtttc atggaaatcc gttgattatt ccaaaaccaa tttggttatc ggattttaat
    29281 cgctacttag acaagaatcg tttgtcacca aagttaaagt cctatattga gaagcagaga
    29341 aagacagctt atccgttact catttttgct tcagaaatta agaaagggga gcagttagaa
    29401 gaaatcttac aggagcaatt tccaaatgag aaaattggct ttgtatcttc tgtaacagag
    29461 gatcgattag agcaagtaca agcttttcga gatggagaac tgacaatact tatcagtacg
    29521 acaatcttgg agcgtggagt taccttccct tgtgtggatg ttttcgtagt agaagccaat
    29581 catcgtttgt ttaccaagtc tagtttgatt cagattggtg gacgagttgg acgaagcatg
    29641 gatagaccga caggagattt gcttttcttc catgatgggt taaatgcttc aatcaagaag
    29701 gcgattaagg aaattcagat gatgaataag gaggctggtc tatgaagtgc ttgttatgtg
    29761 ggcagactat gaagactgtt ttaactttta gtagtctctt acttctgagg aatgatgact
    29821 cttgtctttg ttcagactgt gattctactt ttgaaagaat tggggaagag aactgtccaa
    29881 attgtatgaa aacagagttg tcaacaaagt gtcaagattg tcaattttgg tgtaaagaag
    29941 gagttggagt cagtcataga gcgattttta cttacaatca agctatgaag gattttttca
    30001 gtcggtataa gtttgatgga gacttcctgt taagaaaagt tttcgcttca tttttaagtg
    30061 aggagttgaa aaagtacaaa gagtatcaat ttgttgtaat tcccctaagt cctgatagat
    30121 atgctaatag aggatttaat caggttgagg gcttggtaga ggcagcaggc tttgagtatc
    30181 tggatttatt agagaaaaga gaagagagag ccagttcttc taaaaatcgt tcagagcgct
    30241 tggggacaga acttcctttc tttattaaaa gtggagtcac tattcctaaa aaaatcctac
    30301 ttatagatga tatctatact acaggagcaa ctataaatcg tgttaagaaa ctgttggaag
    30361 aagctggtgc taaggatgta aaaacatttt cccttgtaag atgaggaaaa aatttgcaaa
    30421 aatagaatga aagcgttata ataaaatcat aaaaacaaaa atgtttagaa agaaggtact
    30481 catatgatta aatatagtat ccgtggtgaa aacctagaag taacagaagc aattcgtgat
    30541 tatgtagttt ctaaactcga aaagatcgaa aagtacttcc aaccagaaca agagttggat
    30601 gcccgaatta acttaaaagt ttatcgtgaa aaaacggcta aagtggaagt aacgattccg
    30661 cttggatcta ttactctccg cgcagaagat gtatctcaag atatgtatgg ttcaattgac
    30721 cttgtaactg ataaaattga acgtcagatt cgtaaaaata aaacaaaaat cgagcgtaaa
    30781 aataaaaata aggtagcaac tggtcaatta tttacagatg ctttggtgga agattcaaat
    30841 attgtccagt ctaaagttgt tcgttcaaaa caaattgatt taaaaccaat ggatttggaa
    30901 gaagcaattc tacaaatgga tttattgggg catgatttct ttatctatgt ggatgttgaa
    30961 gatcagacaa ccaatgtgat ttatcgtcgt gaggatggcg aaattggttt gttagaggtt
    31021 aaagaatctt aatttcaata tgtgtaaagg taggtttact gaattgtaaa ctaccttttt
    31081 cttataattg atagaattac tgattacact tttaaaaagt cgctttttga ggggtattat
    31141 ggtataatgg gtgccaagag gttttgaatg aaaaaatttt atgtaagtcc aatttttcct
    31201 attctagtag gattgattgc gtttggagtc ttatccactt tcattatttt tgttaataat
    31261 aatctgttga cggttttaat tttgtttctt tttgtaggag gctatgtttt tttatttaag
    31321 aaactgagag tgcattatac aaggagtgat gtagaacaga tacagtatgt aaaccaccaa
    31381 gcggaagaaa gtttgacagc tctattggaa cagatgcctg taggtgttat gaaattgaat
    31441 ttatcttctg gagaggttga gtggtttaat ccctatgctg aattgatttt gaccaaggaa
    31501 gatggtgatt ttgatttaga agctgttcaa acgattatca aggcttcagt aggaaatccg
    31561 tctacttatg ccaagcttgg tgagaagcgt tatgctgttc atatggatgc ttcttccggt
    31621 gttttgtatt ttgtagatgt atccagggaa caagccataa cagatgaatt ggtaacaagt
    31681 agaccagtga ttgggattgt ctctgtggat aattatgatg atttggagga tgcaacttct
    31741 gagtcagata ttagtcaaat caatagtttt gtagctaatt ttatatcaga gttttcagaa
    31801 aaatacatga tgttttctcg tcgggtaagt atggatcgat tttatctatt tactgactac
    31861 acggtgcttg agggcttgat gaatgataaa ttttctgtta ttgatgcttt cagagaagag
    31921 tcgaaacaga gacagttgcc cttgacctta agtatgggat tttcttatgg cgatggaaat
    31981 catgatgaga tagggaaagt tgctttgctc aatttgaact tggctgaagt acgtggtggc
    32041 gaccaggtgg ttgttaagga aaacgacgaa acgaaaaatc cagtttattt tggtggtggg
    32101 tctgctgctt caatcaagcg tacacggact cgtacgcgcg ctatgatgac agctatttca
    32161 gataagattc ggagtgtaga tcaggttttt gtagtcggtc acaaaaattt agacatggat
    32221 gctttgggct ctgctgtagg tatgcagttg ttcgccagca atgtgattga aaatagctat
    32281 gctctttatg atgaagaaca aatgtctcca gatattgaac gagctgtttc attcatagaa
    32341 aaagaaggag ttacgaagtt gttgtctgtt aaggatgcaa tggggatggt gaccaatcgt
    32401 tctttgttga ttcttgtaga ccattcaaag acagccttaa cattatcaaa agaattttat
    32461 gatttattta cccaaaccat tgttattgac caccatagaa gggatcagga ttttccagat
    32521 aatgcggtta ttacttatat cgaaagtggt gcaagtagtg ccagtgagtt ggtaacggaa
    32581 ttgattcagt tccagaattc taagaaaaat cgtttgagtc gtatgcaagc aagtgttttg
    32641 atggctggta tgatgttgga tactaaaaat ttcacctcgc gagtaactag tcggacattt
    32701 gatgttgcta gctatctcag aacgcgcgga agtgatagta ttgctatcca ggaaatcgct
    32761 gcgacagatt ttgaagaata tcgtgaggtt aatgaactta ttttacaggg gcgtaaatta
    32821 ggttcagatg tactaatagc agaggctaag gacacgaaat gctatgatac agttgttatt
    32881 agtaaggcag cagatgccat gttagccatg tcaggtattg aagcgagttt tgttcttgcg
    32941 aagaatacac aaggatttat ctctatctca gctcgaagtc gtagtaaact gaatgtacaa
    33001 cggattatgg aagagttagg cggtggaggc cactttaatt tggcagcagc tcaaattaaa
    33061 gatgtaacct tgtcagaagc aggtgaaaaa ctgacagaaa ttgtattaaa tgaaataaag
    33121 gaaaaggaga aagaagaatg aaagtaatct ttttagcaga tgttaaagga aaaggtaaaa
    33181 aaggcgaaat taaggaagta ccaacagggt atgcgcaaaa ctttcttatc aaaaagaatc
    33241 tagccaaaga agcgactgct caagctgtag gtgaacttcg tggtaaacaa aaatcggaag
    33301 aaaaagctca cgctgagatg attgcagaag ggaaagcaat taaagcacaa cttgaagcag
    33361 aagaaactgt tgtagaattt gttgaaaaag ttggtccaga tggtcgtacc tttggttcta
    33421 ttaccaataa gaagattgca gaagaattac aaaagcaatt tggaattaag attgataaac
    33481 gtcatattca agtacaagct ccgattcgag cggttggttt gattgatgtg ccagtgaaaa
    33541 tctatcaaga tatcacaagt gtaatcaatc ttcgtgtgaa agaaggataa gtttacacct
    33601 tcttgacaag attgtaaaag gaagggaagt ctgatggcag aagtagaaga gttacgagta
    33661 caacctcaag atatcttagc tgagcaatcc gttttagggg ctatctttat tgatgagagt
    33721 aaacttgttt ttgtgcgaga atacattgag tctcgggact tttttaagta tgcccatcgt
    33781 ttgattttcc aagccatggt cgatttatcc gatcgtggtg atgccataga tgcaacaacg
    33841 gttcgtacta tccttgataa tcaaggtgat ttacagaata ttggtggctt gtcttacttg
    33901 gttgagattg tcaattctgt gccaacttct gctaatgcgg agtattatgc taagattgtt
    33961 gcagaaaaag caatgctacg tcgtttaatt gccaagttga cagagtctgt caaccaagct
    34021 tacgaagcgt cacaaccagc tgatgaaatt attgctcagg cagaaaaagg gctgattgat
    34081 gtcagtgaaa atgcaaatcg aagcgggttt aagaacattc gagatgtgtt gaatctcaac
    34141 tttggaaatc tggaagctcg ctcgcaacaa acgaccgata ttacaggtat tgcgacaggt
    34201 tatcgtgatt tggatcatat gacaacagga cttcatgagg aggagttgat tatcttagca
    34261 gctcgtccag cagttggtaa gacagcattt gccttgaata tcgctcagaa tattgggact
    34321 aagttggaca aaacggttgc tattttttca ctcgaaatgg gtgcggaaag cttggtagac
    34381 cgtatgttag ctgcagaagg cttggtggag tcacattcta tccgtacagg gcaattgaca
    34441 gatgaggagt ggcaaaaata tactattgct cagggtaatc tagctaacgc cagtatctat
    34501 atcgatgata cgccaggtat tcggattaca gagattcgtt ctcgttctcg taaattggct
    34561 caagaaactg gaaatcttgg tttgattttg atagactatt tgcaacttat cacgggaact
    34621 ggtcgagaaa atcgtcaaca agaagtttct gaaatttctc gtcagttgaa aatactagcc
    34681 aaggaattga aggttccagt aatcgctctg agtcagcttt ctcgtggtgt agaacaacgt
    34741 caggacaaga gaccggtctt gtctgatatt cgtgaatctg ggtctattga gcaggacgct
    34801 gatatcgtag cttttctcta tcgcgatgac tactatgaac gtggtggtga agaagaggag
    34861 ggtatcccaa ataataaggt ggaagttatt atcgagaaaa accgtagtgg agctcgtgga
    34921 acagtggaat tgattttcca aaaagaatac aataaatttt caagtatctc aaagagggag
    34981 gcataagatg tcagatgcat ttacagatgt agccaagatg aaaaaaatca aagaagaaat
    35041 caaggcacat gagggacaag tcgtagaaat gactttggag aatggtcgta agcgccaaaa
    35101 aaatagattg ggtaagctaa ttgaagttta tccatcccta tttattgtgg agtttgggga
    35161 tgtggaagga gataaacaag ttaatgttta cgttgaatcc tttacttact cagatattct
    35221 tacagaaaag aatttgattc attatcttga ctaaagtgag aaattttctc actttttctt
    35281 ttttctccga ataatttagg tgaaggcaat catcgcttta tattattttt taaggaggaa
    35341 gaatgaaaat tttaccgttt atagcaagag gaacaagtta ttacttgaag atgtcagtta
    35401 aaaagcttgt tcctttttta gtagtaggat tgatgctagc agctggtgat agtgtctatg
    35461 cctattccag aggaaatgga tcgattgcgc gtggggatga ttatcctgct tattataaaa
    35521 atgggagcca ggagattgat cagtggcgca tgtattctcg tcagtgtact tcttttgtag
    35581 cctttcgttt gagtaatgtc aatggttttg aaattccggc agcttatgga aatgcgaatg
    35641 aatggggaca tcgtgctcgt cgggaaggtt atcgtgtaga taatacaccg acgattggtt
    35701 ccattacttg gtctactgca ggaacttatg gtcatgttgc ctgggtgtca aatgtaatgg
    35761 gagatcagat tgagattgag gaatataact atggttatac agaatcctat aataaacgaa
    35821 ttataaaagc aaacacgatg acaggattta ttcattttaa agatttggat ggtggcagtg
    35881 ttgggaatag tcaatcctca acttcaacag gcggaactca ttattttaag accaagtctg
    35941 ctattaaaac tgaaccccta gttagtgcaa ctgtgattga ttactattat cctggagaga
    36001 aggttcatta tgatcaaatt ctcgaaaaag acggctacaa gtggttgagt tatactgcct
    36061 ataatggaag ctatcgttat gttcaattgg aggctgtgaa taaaaatcct ctaggtaatt
    36121 ctgttctttc ttcaacaggt ggaactcatt attttaagac caagtctgct atcaaaactg
    36181 aacccctagt tagtgcaact gtgattgatt actattatcc tggagagaag gttcattatg
    36241 atcagatact tgaaaaagac ggctacaagt ggttgagtta tacggcttat aacggaagtc
    36301 gtcgctatat acagctagag ggagtgactt cttcacaaaa ttatcagaat caatcaggaa
    36361 atatctctag ctatggatcc aataatagtt caactgtcgg ttggaagaaa ataaatggta
    36421 gttggtatca tttcaaatca aatggttcta aatcaacagg atggctgaaa gatggttcta
    36481 gctggtatta tttgaaatta tctggtgaaa tgcagacagg atggttaaag gagaatggct
    36541 cgtggtatta tctgggtagt tcaggggcaa tgaaaacagg ctggtaccag gtctctggta
    36601 agtggtatta ttcttactct tcaggcgcct tagctgttaa tacgacggtg gatggctaca
    36661 gagtaaacag tgatggagaa cgagtataga aaattggagt aggagaaatt tcctgctctt
    36721 ttctgtaagc agtttccttg acatttttct tattttgcgc tatcatatat acatataata
    36781 tatgggagtc tgtgtacagt ctgagaggaa gtgttaaact tcgaccgcac ctgatctggg
    36841 taatgccagc ggagggaacg atacttagtc taattttgca ccttttccat gtatggtaaa
    36901 ggtttttctt ttttttaaaa ggaaaacgag aagaggaggt tcttatgaaa gcaagcattg
    36961 ccttgcaagt tttaccccta gcacagggga ttgatcggat agctgttatt gatcaggtca
    37021 ttgcttatct gcaaactcaa gaagtgacga tggtagtgac accatttgaa acggtcttgg
    37081 aaggggagtt tgatgagctt atgcgcattc taaaagaagc gctggaagtg gcagggcagg
    37141 aggcagacaa tgtctttgcc aatgtcaaaa taaatgtagg agagatttta agtattgatg
    37201 agaaacttga aaagtatact gagacgacac attagtctat tgggctttct cggagtattg
    37261 tcaatctggc agttagcagg ttttcttaaa cttctcccca agtttatcct gccgacacct
    37321 cttgaaattc tccagccctt tgttcgtgac agagaatttc tctggcacca tagctgggcg
    37381 accttgagag tggctttact ggggctgatt ttgggagttt tgattgcctg tcttatggct
    37441 gtgctcatgg atagtttgac ttggctcaat gacctgattt accctatgat ggtggtcatt
    37501 cagaccattc cgaccattgc catagctcct atcctggtct tgtggctagg ttatgggatt
    37561 ttgcccaaga ttgtcttgat tatcttaacg acaacctttc ccatcatcgt tagtattttg
    37621 gacggtttta ggcattgtga caaggatatg ctgaccttgt ttagtctgat gcgggccaag
    37681 ccttggcaaa tcctgtggca ttttaaaatc ccggttagcc tgccttactt ttatgcaggt
    37741 ctgagggtca gtgtctccta cgcctttatc acaactgtgg tatctgagtg gttgggaggt
    37801 tttgaaggtc ttggtgttta tatgattcag tctaaaaaac tgtttcagta tgataccatg
    37861 tttgccatta ttattctggt gtcgattatc agtcttttgg gtatgaagct ggtcgatatc
    37921 agtgaaaaat atgtgattaa atggaaacgt acttaaaata gagcgttttt gaaaaagaaa
    37981 agaggaaatc aaaatgaaga aaacatggaa agtgttttta acgcttgtaa cagctcttgt
    38041 agctgttgtg cttgtggcct gtggtcaagg aactgcttct aaagacaaca aagaggcaga
    38101 acttaagaag gttgacttta tcctagactg gacaccaaat accaaccaca cagggcttta
    38161 tgttgccaag gaaaaaggtt atttcaaaga agctggagtg gatgttgatt tgaagttgcc
    38221 accagaagaa agttcttctg acttggttat caacggaaag gcaccatttg cagtgtattt
    38281 ccaagactac atggctaaga aattggaaaa aggagcagga atcactgccg ttgcagctat
    38341 tgttgaacac aatacatcag gaatcatctc tcgtaaatct gataatgtaa gcagtccaaa
    38401 agacttggtt ggtaagaaat atgggacatg gaatgaccca actgaacttg ctatgttgaa
    38461 aaccttggta gaatctcaag gtggagactt tgagaaggtt gaaaaagtac caaataacga
    38521 ctcaaactca atcacaccga ttgccaatgg cgtctttgat actgcttgga tttactacgg
    38581 ttgggatggt atccttgcta aatctcaagg tgtagatgct aacttcatgt acttgaaaga
    38641 ctatgtcaag gagtttgact actattcacc agttatcatc gcaaacaacg actatctgaa
    38701 agataacaaa gaagaagctc gcaaagtcat ccaagccatc aaaaaaggct accaatatgc
    38761 catggaacat ccagaagaag ctgcagatat tctcatcaag aatgcacctg aactcaagga
    38821 aaaacgtgac tttgtcatcg aatctcaaaa atacttgtca aaagaatacg caagcgacaa
    38881 ggaaaaatgg ggtcaatttg acgcagctcg ctggaatgct ttctacaaat gggataaaga
    38941 aaatggtatc cttaaagaag acttgacaga caaaggcttc accaacgaat ttgtgaaata
    39001 atgacagaaa ttagactaga gcacgtcagt tatgcctatg gtcaggagag gattttagag
    39061 gatatcaacc tacaggtgac ttcaggcgaa gtggtttcca tcctaggccc aagtggtgtt
    39121 ggaaagacca ccctctttaa tctaatcgct gggattttag aagttcagtc agggagaatt
    39181 gtccttgatg gtgaagaaaa tcccaagggg cgcgtgagtt atatgttgca aaaggatctg
    39241 ctcttggagc acaagacggt gcttggaaat atcattctgc ccctcttgat tcaaaaggtg
    39301 gataaggcag aagctatttc ccgagcggat aaaattcttg cgaccttcca gctgacagct
    39361 gtaagagaca agtatcctca tgaacttagc ggtgggatgc gccagcgtgt agccttactc
    39421 cggacctacc tttttgggca caagctcttt ctcttagatg aggcctttag cgccttggat
    39481 gagatgacaa agatggaact ccacgcttgg tatcttgaga ttcacaagca gttgcagcta
    39541 acaaccctga tcatcacgca tagtattgag gaggccctca atctcagcga ccgcatctat
    39601 atcttgaaaa atcgccctgg gcagattgtt tcagaaatta aactagattg gtctgaagat
    39661 gaggacaagg aagtccaaaa gattgcctac aaacgtcaaa ttttggcgga attaggctta
    39721 gataagtaga aaaataggga gttggtgaag attatccttt accagcgccc tttttctttt
    39781 aaaaatgaga aaatttcggt ataatagtca aacaaggtca aggtttaaag agagaggtgg
    39841 gtttgttatg agatttaaaa atacatcgga tcatattgag gcctacatca aggcgatttt
    39901 agatcaatct ggtatcgtgg agttgcaacg gagtcagttg gcagatacct ttcaggttgt
    39961 tcctagtcag attaactacg tgatcaagac acgctttacg gaaagtagag gctacttggt
    40021 tgaaagtaag cgtggtggcg gaggctacat tcgtatagga cggattgagt tttctagtca
    40081 tcatgaaata ctccgggagc tgctttactc gattggtgag cgagtcagtc aagaaattta
    40141 tgaggatatt ctccagcttt tggttgagca ggaattgatg accaagcagg agatgaattt
    40201 gctagtatca gtagctttgg atcgcgtttt aggagaagaa gctccagttg ttcgagcaaa
    40261 catgctacgt cagatcatac aagaagtaga tagaaaaggg aagtaagatg aactattcaa
    40321 aagcattgaa tgaatgtatc gaaagtgcct acatggttgc tggacatttt ggagctcgtt
    40381 atctagagtc ttggcacttg ttgattgcca tgtctaatca cagttatagt gtagcagggg
    40441 caactttaaa tgattatccg tatgagatgg accgtttaga agaggtggct ttggaactga
    40501 ctgaaacgga ctatagccag gatgaaacct ttacggaatt gccgttctcc cgtcgtttgc
    40561 aggttctttt tgatgaagca gagtatgtag cgtcagtggt ccatgctaag gtactaggga
    40621 cagagcacgt cctctatgcg attttgcatg atggcaatgc cttggcgact cgtatcttgg
    40681 agagggctgg tttttcttat gaagacaaga aagatcaggt caagattgct gctcttcgtc
    40741 gaaatttaga agaacgggca ggctggactc gtgaagatct caaggcttta cgccaacgcc
    40801 atcgtacagt agctgacaag caaaattcta tggccaatat gatgggcatg ccgcagactc
    40861 ctagtggtgg tctcgaggac tatacgcatg atttgacaga gcaagcgcgt tctggcaagt
    40921 tagaaccagt catcggtcgg gacaaggaaa tctcacgtat gattcaaatc ttgagccgta
    40981 agactaagaa caaccctgtc ttggttgggg atgctggtgt cgggaaaaca gctctggcgc
    41041 ttggtcttgc tcagcgtatt gctagtggtg acgtgcctgc ggaaatggct aagatgcgcg
    41101 tgttagaact tgatttgatg aatgtcgttg cagggacacg cttccgtggt gactttgaag
    41161 aacgcatgaa taatatcatc aaggatattg aagaagatgg ccaagtcatc ctctttatcg
    41221 atgaacttca caccatcatg ggttctggta gcgggattga ttcgactctg gatgcggcca
    41281 atatcttgaa accagccttg gcgcgtggaa ctttgagaac ggttggtgcc accactcagg
    41341 aagaatatca aaaacatatc gaaaaagatg cagcactttc tcgtcgtttc gctaaagtga
    41401 cgattgaaga accaagtgtg gcagatagta tgactatttt acaaggtttg aaggcgactt
    41461 atgagaaaca tcaccgtgta caaatcacag atgaagcggt tgaaacagcg gttaagatgg
    41521 ctcatcgtta tttaaccagt cgtcacttgc cagactctgc tatcgatctc ttggatgagg
    41581 cggcagcaac agtgcaaaat aaatcaaagc atgtaaaagc agacgattct gacttgagtc
    41641 cagctgacaa ggccttgatg gatggcaagt ggaaacaggc agcccagcta atcgcaaaag
    41701 aagaggaagt gcctgtctat aaagacttgg tgacagaatc tgatattttg accaccttga
    41761 gtcgcttgtc aggtatcccc gttcaaaaac tgactcagac tgatgccaag aaatacttaa
    41821 acttggaagc tgaactgcac aaacgtgtca tcggtcaaga ccaagctgtt tcaagtatta
    41881 gtcgtgccat tcgccgcaat cagtcaggaa ttcgcagtca caagcgtccg atcggttcct
    41941 ttatgttcct aggacccaca ggtgtcggta agaccgagtt ggccaaggct ttggcagaag
    42001 ttctctttga tgacgaatca gcccttatcc gctttgatat gagtgagtat atggagaaat
    42061 tcgcagccag ccgtctaaat ggagctcctc caggctatgt gggttacgaa gaaggtgggg
    42121 agttgacaga gaaggttcgc aataaaccct attccgttct cctctttgat gaggtagaga
    42181 aggcccatcc agatatcttt aatgttctct tgcaggttct ggatgacggt gtcttgacag
    42241 atagcaaggg acgcaaggtc gatttttcaa ataccattat cattatgaca tcgaacttag
    42301 gtgcgactgc ccttcgtgat gataagactg ttggttttgg ggctaaggat attcgttttg
    42361 accaggaaaa tatggaaaaa cgcatgtttg aagaactgaa aaaagcttat agaccggaat
    42421 tcatcaaccg tattgatgag aaggtggtct tccatagcct atctagtgac catatgcagg
    42481 aagtggtgaa gattatggtc aagcctttag tggcaagttt ggctgaaaaa ggcattgact
    42541 tgaaattaca agcttcagct ctgaaattgt tagcaaatca aggatatgac ccagagatgg
    42601 gagctcgccc acttcgcaga accctgcaaa cagaagtgga ggacaagttg gcagaacttc
    42661 ttcttaaggg agatttagtg gcaggcagca cacttaagat tggtgtcaaa gcaggccagt
    42721 taaaatttga tattgcataa aagaataaaa gtatcagcat ctgaccataa gtcacagtgg
    42781 agtgaaactc aatgaaaatc aaagagcaaa ctaggcagct agccgcaggt tgctcaaaac
    42841 actggtttga ggttgcagat agagctgacg tggtttgaag agattttcga agagtatgaa
    42901 actaaaacct atagcttcta aacgatccgt ggttttcacc attcaacaca aaattcatat
    42961 gtttattacc ctccgtcgta tttgtcttag agcgtgtgta gtagaaaaag agcagtctta
    43021 tctgaaattt ttattctttc aaaagagacc tgtttctttt ttgcatgtca aatccgttct
    43081 agctggtatt tgaaaaatca aactaatatt caataaaaat caaagaacaa actaggaagc
    43141 tagccgcagg ttgctcaaaa cactgttttg aggttgtaga tagagctgac gtagtttgaa
    43201 gagattttcg aagagtataa gctgcaagat gaatgatttt cttgtattga cgttgttgtt
    43261 gacaaaaagt agcggataaa tgaaatccat tccattatca tagatgatag gctggtagga
    43321 aattttcaaa tagcatacag gaaatagatg tatggagttc tggtagtaga aagggagaga
    43381 gatgaacatt ttagttgcag atgacgagga aatgattaga gaaggaattg cagcatttct
    43441 gacagaagag ggttatcatg tcattatggc taaggatgga caagaggtct tggaaaaatt
    43501 tcaagatctc cctatccatc tcatggtact ggatttaatg atgcctagga agagtggttt
    43561 tgaagtgtta aaagaaatca atcaaaagca cgatattcct gtcatcgtct tgagtgctct
    43621 gggagatgaa actactcagt cacaggtatt tgatctctat gctgatgatc atgtgacaaa
    43681 acctttttct ttggtactgc ttgtcaagcg tattaaggcg cttatcagac gttactacgt
    43741 catagaggat ctttggcgat atcaggatgt aacagtggat tttacctctt acaaagcaca
    43801 ttataaaaat gaagaaattg atctcaaacc aaaggaatta ctggtactaa agtgtttgat
    43861 tcagcataaa aatcaagttt taagtagaga gcagatattg gaagaaattt caaaagatgt
    43921 agctgattta ccttgtgata gggtcgttga tgtctatatt cgtactcttc gcaaaaaatt
    43981 agctttagat tgtatcgtga ctgtgaaaaa tgttgggtat aagattagct tatgataaaa
    44041 aatcctaaat tattaaccaa gtctttttta agaagttttg caattctagg tggtgttggt
    44101 ctagtcattc atatagctat ttatttgacc tttccttttt attatattca actggagggg
    44161 gaaaagttta atgagagcgc aagagtgttt acggagtatt taaagactaa gacatctgat
    44221 gaaattccaa gcttactcca gtcttattca aagtccttga ccatatctgc tcaccttaaa
    44281 agagatattg tagataagcg gctccctctt gtgcatgact tggatattaa agatggaaag
    44341 ctatcaaatt atatcgtgat gttagatatg tctgttagta cagcagatgg taaacaggta
    44401 accgtgcaat ttgttcacgg ggtagatgtc tacaaagaag caaagaatat tttgcttttg
    44461 tatctcccat atacattttt ggttacaatt gctttttcct ttgttttttc ttatttttat
    44521 actaaacgct tgctcaatcc tcttttttac atttcagaag tgactagtaa aatgcaagat
    44581 ttggatgaca atattcgttt tgatgaaagt aggaaagatg aagttggtga agttggaaaa
    44641 cagattaatg gtatgtatga gcacttgttg aaggttattc atgagttgga aagtcgtaat
    44701 gagcaaattg taaaattgca aaatcaaaag gtttcctttg tccgtggagc atcacatgag
    44761 ttgaaaaccc ctttagccag tcttagaatt atcctagaga atatgcagca taatattgga
    44821 gattacaaag atcatccaaa atatattgca aagagtataa ataagattga ccagatgagc
    44881 cacttattgg aagaagtact ggagtcttct aaattccaag agtggacaga gtgtcgtgag
    44941 accttgactg ttaagccagt tttagtagat attttatcac gttatcaaga attagctcat
    45001 tcaataggtg ttacaattga aaatcaattg acagatgcta ccagggtcgt catgagtctt
    45061 agggcattgg ataaggtttt gacaaacctg attagtaatg caattaaata ttcagataaa
    45121 aatgggcgtg taatcatatc cgagcaagat ggctatctct ctatcaaaaa tacatgtgcg
    45181 cctctaagtg accaagaact agaacattta tttgatatat tctatcattc tcaaatcgtg
    45241 acagataagg atgaaagttc cggtttgggt ctttacattg tgagtaatat tttagaaagc
    45301 tatcaaatgg actatagttt tctcccttat gaacacggta tggaatttaa gattagcttg
    45361 tagacagatt agttttttat taaagttcac atagggttaa cataagtgta ttattcttta
    45421 tatagataaa aatatagata aaagaaagga tactaatatg gtattagcga ttattttagt
    45481 aacattcctt attcgattga tttttttaaa gcgttcgata gagaatgaga aacgaatcct
    45541 tagcaatggc gggaaagaat ttggagttga gaatacaaaa cgattaacgt tggctcatat
    45601 tgttttttat ctctcttgcc tcgttgaagc aatggtgcac aagacaattt ttgatggcat
    45661 gggcatggtt ggtttagtct tgcttatttt ttctatgctg atgttgatgt tggtgattca
    45721 cttgttggga gatatttgga cagtgaagct tatgcttgtc aataatcaca aatatgtaga
    45781 tcatatcttg tttaggacag taaaacatcc taattacttt ttaaatattc ttcctgagtt
    45841 gattggcttg accttgttga gtcatgctta tgtgactttt gttttagttt ttccagttta
    45901 tgcagttatt ttgtatcgac gaatagctga agaggaaaag ctattacatg aagttataat
    45961 cccaaatgga agcataaaga gataaataca aaattcgatt tatatacagt tcatattgaa
    46021 gtgatatagt aaggttaaag aaaaaatata gaaggaaata aacatgtttg catcaaaaag
    46081 cgaaagaaaa gtacattatt caattcgtaa atttagtatt ggagtagcta gtgtagtagt
    46141 tgctagcttg ttcttaggag gagtagttca tgcagaagag gttggtggta ggaatacccc
    46201 cacggttaca tctagtgggc aagatatatc gaagaagtat gctgatgaag tcgagtcgca
    46261 tctaaaaaaa atattgagtg agatccaaac acaattagat agaaaacgac ataccaaaac
    46321 tgtagcgcta attaacgagt tgcaaaacat taagaaaacg tatttgtata atttaaatgt
    46381 tttaaaagag aagtctgagt tgccgtcaaa aataaaagca aagttagaag tagcttttga
    46441 tcagtttaaa aaagatacat tgaaaccagg agaaaaggta gcagaagctg agaagaaagt
    46501 tgcagaagct aagaaaaaag ccgaggatca aaaagaacaa gatcgccgta actacccaac
    46561 caatacttac aaaacgcttg aacttgaaat tgctgagtcc gatgtgaaag ttaaagaagc
    46621 ggagcttgaa ctagtaaaag aggaagctaa ggaatctcga aacgaggaaa aagttaagca
    46681 agcaaaagcg aaagttgaga gtgaaaaagc agaggctata aggttagaag aaatcaagac
    46741 agatcgtgaa gaagctaaac gaaaagcaga tgctaagttg aaggaagctg ttgaaaacaa
    46801 tgcagcgact tcagagcaag gtgaaccaaa gaggcgggta aaacgaggag ttcttggaga
    46861 gccagcaaca cctgataaaa aagaaaatga tgcgaagtct tcagattcta gcgtaggtga
    46921 agaaactctt ccaagcccat ccctgaaacc agaaaaaaag gttgcagaag ctgagaagaa
    46981 ggttgcagaa gctgagaaaa aagccaagga tcaaaaagaa gaagatcgcc gtaactaccc
    47041 aaccaatact tacaaaacgc ttgaacttga aattgctgag tccgatgtga aagttaaaga
    47101 agcggagctt gaactagtaa aagaggaagc taaggaatct cgaaacgagg aaaaagttaa
    47161 gcaagcaaaa gcgaaagttg agagtaaaaa agctgaggct acaaggttag aaaaaatcaa
    47221 gacagatcgt aaaaaagcag aagaagctaa acgaaaagca gcagaagaag ctaaacgaaa
    47281 agcagcagaa gaagataaag ttaaagaaaa accagctgaa caaccacaac cagcgccggc
    47341 tccaaaacca gaaaaaccag ctccagctcc aaaaccagag aatccagctg aacaaccaaa
    47401 agcagaaaaa ccagcacaac catctactcc aaaaacaggc tggaaacaag aaaacggtat
    47461 gtggtacttc tacaatactg atggttcaat ggcgacagga tggctccaaa acaatggctc
    47521 atggtactat ctaaacgcta atggttcaat ggcaacagga tggctccaat acaatggttc
    47581 atggtactac ctaaacgcta atggtgatat ggcgacagga tggctccaaa acaatgg
//
LOCUS       DAVHIZ010000010        47627 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.010, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000010 DAVHIZ010000000
VERSION     DAVHIZ010000010.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 47627)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 47627)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..47627
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.010"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1026
                     /locus_tag="VVO18_000566"
     CDS             <1..1026
                     /locus_tag="VVO18_000566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF87 domain-containing protein"
                     /protein_id="HEU5585769.1"
                     /translation="KDNSGYEKIIRSAILKYELDNQNGRIIIKALIRGDEFSKKVQTL
                     DDVLAGVLELELEEKITHPNIVEYHFYYKKPDRLILSPHDHKKEIDSLDIDLGYDITY
                     NPIKCPHILVSGGTGSGKSIFISFLIIELLKRNSTLYIADPKNSDLGSLSHYLSDKYV
                     ATTPNSIARIVRLVVEQMQARYQTMRDNFHYGSNFADHGFKPVWLIFDEMGAFQASAT
                     DKKSKEVITEVMDGIKQIILLGRQAGVFILISAQQMRAETLNTDLRDNLGLRIALGAN
                     SIEGYRMVFGTATPDKFKSIEEKGAGYLYMQGSGKEKAQYWESPYLDTTQFDFIKELQ
                     LYVTKSK"
     gene            1128..1436
                     /locus_tag="VVO18_000567"
     CDS             1128..1436
                     /locus_tag="VVO18_000567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004195544.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585770.1"
                     /translation="MNDFLKPELLGNKFVAVKGYTEVLDRETNKPVALRLNVSIQDED
                     SDFFMEMIQIKVNTLSPTATPQLLSDKKTCPIKLSNLTVGQFNGNLWFSCNDVVPISK
                     "
     gene            1453..2181
                     /locus_tag="VVO18_000568"
     CDS             1453..2181
                     /locus_tag="VVO18_000568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269871.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEU5585771.1"
                     /translation="MAKLFAISDIHGHLDEFLSALSKVDLSDKNNRLILIGDYIDNGH
                     QSFQVISKIIELEELHPNQIITLLGNHEEWFYDWLILENPTSSSFSETIKSFFSPEEL
                     TYILKSNVNNFEAGVRNEIKNNIKFNPFINWFKKRYRDKRYYETDTQIFVHAGIDEEA
                     GKLWKDLTSSEMFTNKFPITTGGFFKDIVSGHIASWEVAKDKTYQGKIYFDGKNHYFI
                     DGDVYHSKTIPVICYDTVTKSYQY"
     gene            2256..3029
                     /locus_tag="VVO18_000569"
     CDS             2256..3029
                     /locus_tag="VVO18_000569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEU5585772.1"
                     /translation="MKTLLIGDLHLKSQLILPIVDRIIQTHNIKRVIFLGDYVDLHGQ
                     TNNIQLYAKDLTFLYSWKIDKEQNGIEVINLIGNHDAYYLLGDQAPFSIQNLEVFFAV
                     QGLLQDLKLQVAYQLDDYLISHAGFNQIFDPQKWHFTPYTKEHEEELDILAYTIGPMR
                     GGEALGGSPLWAHFRELELLPNQDFPKQIVGHTPKESIDISKNVIGIDTFSLYIDKDN
                     KYQFIGNGDLLVYDQGHLEIISTNWATDETLKQLPKPQI"
     gene            3201..3995
                     /locus_tag="VVO18_000570"
     CDS             3201..3995
                     /locus_tag="VVO18_000570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rep protein"
                     /protein_id="HEU5585773.1"
                     /translation="MSYNRKIIRTSSYLEIWEYESPIFSNDTTQIDEEHISLKEKKKR
                     RTFEELTTAEQDERIKRISNTRKNSKWKLQRLIDTNFDDRTSFLTLTTKENIQNRYEF
                     NLLFDKFIKRLNYHMYHSKKRLIKYIAVLERQKRGAWHAHILLFSFPFIPHKELLTIW
                     GLGAVRINKLHNLDDSSNAGRYVGKYMEKGIGQELLESLGKKAFYSSRNLQKPEEIKL
                     FTSESLDNLVKNEDILYESNYISKVFRKGHLIDNKVKYKKIKLSKE"
     gene            4003..4272
                     /locus_tag="VVO18_000571"
     CDS             4003..4272
                     /locus_tag="VVO18_000571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5585774.1"
                     /translation="MQVILPTEQVQEIQSMITNLLQNEISHFKEDLGLDSPYLNKGQT
                     CKYLGISNNTLDGWIQKGLPVIKIGKTVRFNKNEIDKWLCRKAML"
     gene            4314..5534
                     /locus_tag="VVO18_000572"
     CDS             4314..5534
                     /locus_tag="VVO18_000572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014619928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific integrase"
                     /protein_id="HEU5585775.1"
                     /translation="MTVTKTNSNTYNLKVYIPKEIRPKMGIKGNHFVKRYKTRKEAKE
                     AELEILTKIHQLENGEDILLSKTNDILFSEFFNNIWWDSYKAGQTTSTTRPPTQVTID
                     NTKTVFRKHILPMFGNYSINFLNQNKQVVLNLMTAKAEEYANFKVIRSYVNSIFDWAE
                     ELEYIESNRLSKTIKRIKATKKLKLQESKNEEDLYLSSEELQDWFDAFREDLENDKLS
                     LKDYVLFFTTFILSDRKSESYALHWKNIDLENAQIDLRHALDKYKNVKSTKGNKKTIF
                     SIPSYLVSLLSEWKKQQKYELAKFGIMQTSDQLVFTYIDTKGNVNSPLHVDYLNNKMN
                     SVKRRHPKLKHATPHKLRHTGATLAKKAGMSLEAISEALTHSDTITTKTYVNTSNIVP
                     LSAGQVAYQHLKNK"
     gene            complement(5642..6034)
                     /gene="rpsI"
                     /locus_tag="VVO18_000573"
     CDS             complement(5642..6034)
                     /gene="rpsI"
                     /locus_tag="VVO18_000573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002942223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S9"
                     /protein_id="HEU5585776.1"
                     /translation="MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADL
                     RLVINQPFAVTSTVGSYDVFVNVIGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAG
                     LLTRDSRKVERKKPGLKKARKASQFSKR"
     gene            complement(6053..6499)
                     /gene="rplM"
                     /locus_tag="VVO18_000574"
     CDS             complement(6053..6499)
                     /gene="rplM"
                     /locus_tag="VVO18_000574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003083327.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L13"
                     /protein_id="HEU5585777.1"
                     /translation="MNKTTFMAKPGQVERKWYVVDATDVPLGRLSAVVASVLRGKNKP
                     TFTPHTDTGDFVIVINAEKVKLTGKKATDKIYYTHSNHPGGLKQISAGELRSKNAVRL
                     IEKSVKGMLPHNTLGRAQGMKLKVFVGAEHTHAAQQPEVLDISGLI"
     gene            6855..7172
                     /locus_tag="VVO18_000575"
     CDS             6855..7172
                     /locus_tag="VVO18_000575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF960 domain-containing protein"
                     /protein_id="HEU5585778.1"
                     /translation="MAFTNTHMRSASFGIVTSLPDDIIDSFWYIIDHFLKNVFELEEE
                     LEFQLLNNQGKITFHFSSQHLPTAIDFDFNHPFDPRYPPRVLVLDMDGRETILLPEEN
                     DLF"
     gene            complement(7217..8029)
                     /gene="folK"
                     /locus_tag="VVO18_000576"
     CDS             complement(7217..8029)
                     /gene="folK"
                     /locus_tag="VVO18_000576"
                     /EC_number="2.7.6.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-amino-4-hydroxy-6-
                     hydroxymethyldihydropteridine diphosphokinase"
                     /protein_id="HEU5585779.1"
                     /translation="MDQLQIKDLEMFAYHGLFPSEKELGQKFVVSAILSYDMTKAATD
                     LDLTASVHYGELCQQWTTWFQETSEDLIETVAYKLVERTFESYPLVQEMKLELKKPWA
                     PVHLSLDTCSVTIHRRKQRAFIALGSNMGDKQVNLKQAIDKLRARGIHILKESSVLET
                     EPWGGVEQDSFANQVVEVETWLPAQDLLETLLAIESELGRVREVHWGPRLIDLDLLFV
                     EDQILYTDDLILPHPYIAERLFVLESLQEIAPHFIHPILKQPIRNLYDALKK"
     gene            complement(8072..8626)
                     /gene="folE"
                     /locus_tag="VVO18_000577"
     CDS             complement(8072..8626)
                     /gene="folE"
                     /locus_tag="VVO18_000577"
                     /EC_number="3.5.4.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="HEU5585780.1"
                     /translation="MDTQKIEAAVKMIIEAVGENVNREGLQETPARVARMYQEIFSGL
                     GQTAEEHLSKSFEIIDDNMVVEKDIFFHTMCEHHFLPFYGRAHIAYIPDGRVAGLSKL
                     ARTVEVYSKKPQIQERLNIEVADALMDYLGAKGAFVVIEAEHMCMSMRGVRKPGTATL
                     TTVARGLFETDKDLRDQAYRLMGL"
     gene            complement(8607..9929)
                     /locus_tag="VVO18_000578"
     CDS             complement(8607..9929)
                     /locus_tag="VVO18_000578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000658404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional folylpolyglutamate
                     synthase/dihydrofolate synthase"
                     /protein_id="HEU5585781.1"
                     /translation="MKEFENNQWIAHYRTDQPHFGLERMVELLALRGNPHLKLKVIHV
                     GGTNGKGSTIAFLKNMLEKMGLRVGVFSSPYLIHYTDQISINGESIPEARLEALMGDY
                     QSLLEGEAAANLQGTTEFEIITAIAYDYFASEQVDVAIMEVGMGGLLDSTNVCQPILT
                     GITTIGLDHVALLGDTLEAIAEQKAGIIKQGIPLVTGHIAPEALAVIDCIAEGKDAPR
                     LAYGANYHVSHQENVVTGEVFDYTSSLRQGRFQTGLLGLHQIENAGMAIALLDTFCKE
                     DGRELVSNDLLGQALEETSWPGRLEIVSRDPLMILDGAHNPHAIKALLVTLQERFADH
                     HKEILFTCIKTKALEDMLDLLGAMPDTELTLTHFADSRATDESVLKEAAKSRNLSYQD
                     WHDFLDQNLTDKKEEKQTVRIVTGSLYFLSQVRAYLMERKNENGYTKD"
     gene            complement(9931..10908)
                     /gene="folP"
                     /locus_tag="VVO18_000579"
     CDS             complement(9931..10908)
                     /gene="folP"
                     /locus_tag="VVO18_000579"
                     /EC_number="2.5.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydropteroate synthase"
                     /protein_id="HEU5585782.1"
                     /translation="MVKSLEGVTDMLSKANRAKTAICGIINVTPDSFSDGGQFFALEQ
                     ALQQARKLIAEGASMLDIGGESTRPGSSYYVEIEEEIQRVVPVIKAIRKESDVLISID
                     TWKSQVAEAALAAGANLVNDITGLMGDEKMAHVIAKDGAKVVIMFNPVMARPQHPSSL
                     IFPHFGFNQAFTEEELADFETLPIEELMETFFERALARANQAGIAQENILLDPGIGFG
                     LTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFHNRDTA
                     SAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK"
     gene            complement(11002..11709)
                     /locus_tag="VVO18_000580"
     CDS             complement(11002..11709)
                     /locus_tag="VVO18_000580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260476.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5585783.1"
                     /translation="MKEKNIWKELLNRAVWLLVFLLATILYQIPIGVTAILTLNAVPL
                     LQSGLIVTGISIVVLVLFIIGARKTQLASFNFSFFRAKDLARLGLSYLVIICSNILGS
                     ILLQLSNETTTANQSQINDMVQNSSLISSFFLLALLAPICEEILCRGIVPKKIFRGKE
                     NLGFVVGTIVFALLHQPSNLPSLLIYGGMSIVLSWTAYKTQRLEMSILLHMIVNGVAF
                     CLLALVVIMSRTLGISV"
     gene            complement(11762..13180)
                     /locus_tag="VVO18_000581"
     CDS             complement(11762..13180)
                     /locus_tag="VVO18_000581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359314.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NCS2 family permease"
                     /protein_id="HEU5585784.1"
                     /translation="MDKLFKLKENGTDVRTEVLAGLTTFFAMSYILFVNPQILSQTGM
                     PAQGVFLATIIGAVAGTLMMAFYANLPYAQAPGMGLNAFFTFTVVFGLGYSWQEALAM
                     VFICGIISLIITLTNVRKMIIESIPNALRSAISAGIGVFLAYVGIKNAGLLKFTIDPG
                     NYTVVGEGADKAQATIAANSSAVPGLVSFNNPAVLVALAGLAITIFFVIKGIKGGIIL
                     SILTTTVLAIAVGLVDLSSIDFANNHVGAAFEDLKTIFGAALGSEGLGALISDTARLP
                     ETLMAILAFSLTDIFDTIGTLIGTGEKVGIVATNGENHQSAKLDKALYSDLIGTSIGA
                     IAGTSNVTTYVESAAGIGAGGRTGLTALVVAICFAISSFFSPLLAIVPTAATAPILII
                     VGIMMLASLKNIHWDDMAEAVPAFFTSIFMGFSYSITQGIAVGFLTYTLTKLVKGQAK
                     DVHVMIWILDALFILNYISMAL"
     gene            13370..14182
                     /locus_tag="VVO18_000582"
     CDS             13370..14182
                     /locus_tag="VVO18_000582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000162344.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5585785.1"
                     /translation="MTKKIIALDLDGTLLNSDSQISDFTKETIKKVTEKGHQVIITTG
                     RPYRMSKDFYRELGLDTPMINFNGSLTHLPDQVWDFEKCLTVDKKYLLDMVQRSEDIQ
                     ADFIAGEYRKKFYITNPNEEIANPKLFGVEAFQPEDQFQPELVTKDPNCILLQTRASD
                     KYALAKDMNAFYQHQLSINTWGGPLNILECTPKGVNKAFALDYLLKIMNRDKKDLIAF
                     GDEHNDTEMLAFAGKGYAMKNANPELLPYADEQISLTNDQDGVAKTLQDLFL"
     gene            14521..15540
                     /gene="adhP"
                     /locus_tag="VVO18_000583"
     CDS             14521..15540
                     /gene="adhP"
                     /locus_tag="VVO18_000583"
                     /EC_number="1.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase AdhP"
                     /protein_id="HEU5585786.1"
                     /translation="MKAVVVNPESTGVAIEEKVLRPLETGEALVEVEYCGVCHTDLHV
                     AHGDFGQVPGRVLGHEGIGIVKEIAPDVKSLKVGDRVSVAWFFEGCGTCEYCTTGRET
                     LCRTVKNAGYSVDGGMAEQCIATADYAVKVPDGLDPAQASSITCAGVTTYKAIKEAKV
                     EPGQWVVLYGAGGLGNLAVQYAKKVFNAHVIAVDINNDKLTLAKEVGADIVINGLEVE
                     DVAGLIKEKTDGGAHSAVVTAVSKVAFNQAVDSIRAGGRVVAVGLPSEMMELSIVKTV
                     LDGIQVIGSLVGTRKDLEEAFQFGAEGLVVPVVQKRPVEDAVAIFDEMEKGQIQGRMV
                     LDFTH"
     gene            15773..16762
                     /gene="manX"
                     /locus_tag="VVO18_000584"
     CDS             15773..16762
                     /gene="manX"
                     /locus_tag="VVO18_000584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose transporter subunit IIAB"
                     /protein_id="HEU5585787.1"
                     /translation="MSIGIIIASHGEFAAGIHQSGSMIFGEQEKVQVVTFMPNEGPDD
                     LYAKFNNAVAAFDAEDEVLVLADLWSGSPFNQASRVMGENPERKFAIITGLNLPMLIQ
                     AYTERLMDAAAGVEKVAANIIKEAKDGIKALPEELNPVEEVASAAAAPVAQTAIPEGT
                     VIGDGKLKINLARLDTRLLHGQVATAWTPDSKANRIIVASDNVAKDDLRKELIKQAAP
                     GNVKANVVPIQKLIEISKDPRFGETHALILFETPQDALRAIEGGVPIKTLNVGSMAHS
                     TGKTLVNTVLSMDKEDVATFEKMRDLGVEFDVRKVPNDSKKDLFDLINKANVK"
     gene            16790..17593
                     /locus_tag="VVO18_000585"
     CDS             16790..17593
                     /locus_tag="VVO18_000585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter subunit
                     IIC"
                     /protein_id="HEU5585788.1"
                     /translation="MSIISMVLVIVVAFFAGLEGILDQFQFHQPLVACTLIGLVTGHL
                     EAGIILGGSLQMIALGWSNIGAAIAPDAALASVAAAIIMVLGGDFTKTGIGVAQAVAI
                     PLAVAGLFLTMIVRTISVGLVHTADAAAKKGDFGAVERAHFIALLFQGLRIALPAALL
                     LMVPTETVQSILSAMPDWLKDGMAIGGGMVVAVGYAMVINMMATREVWPFFALGFVLA
                     AVSDITLIGFGAIGVAIALIYLHLSKTGGNGGGGAATSNDPIGDILEDY"
     gene            17617..18528
                     /locus_tag="VVO18_000586"
     CDS             17617..18528
                     /locus_tag="VVO18_000586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU5585789.1"
                     /translation="MTEKLQLTKSDRKKVWWRSTFLQGSWNFERMQNLGWAYTLIPAI
                     KKLYTKKEDQIAALERHLEFFNTHPYVAAPVMGVTLALEEERANGVEIDDAAIQGVKI
                     GMMGPLAGIGDPVFWFTVRPILGSLGASLALTGNILGPLLFFVAWNLIRMSFLWYVQE
                     IGYKAGSEITKDMSGGILQDITKGASILGMFILAVLVQRWVNIKFAFDVSKVQLDEKA
                     YIHWDKLPEGSKGIQEAFAQVGQGLSQTPEKVTTFQQNLDMLIPGLSGLLLTLLCMYL
                     LKKKVSPITIILALFAVGIVAHVLHIM"
     gene            complement(18584..19918)
                     /gene="pepC"
                     /locus_tag="VVO18_000587"
     CDS             complement(18584..19918)
                     /gene="pepC"
                     /locus_tag="VVO18_000587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000991632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase C"
                     /protein_id="HEU5585790.1"
                     /translation="MNAIQESFTDKLFANYEANVKYQAIENAASHNGIFAALERRQSH
                     VDNTPVFSLDLTKDKVTNQKASGRCWMFAALNTFRHKLISQYKLENFELSQAHTFFWD
                     KYEKSNWFLEQVIATSDQELTSRKVSFLLQTPQQDGGQWDMVVSLFEKYGVVPKSVYP
                     ESVSSSSSRDLNAILNKLLRQDAQILRDLLVSGADQVTVQAKKEDLLQEIFNFLAMSL
                     GLPPRKFDFAYRDKDNNYKSEKGITPQEFYKKYVNLPLEDYVSVINAPTADKPYGKSY
                     TVEMLGNVVGSRAVRYINVPMERLKELAIAQMQAGETVWFGSDVGQLSNRKAGILATD
                     VYDFESSMDIKLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKSTKWKVENSWGDKVG
                     TDGYFVASDAWMDEYTYQIVVRKELLTAEEQAAYGAEPIVLAPWDPMGALAK"
     gene            complement(20135..20857)
                     /locus_tag="VVO18_000588"
     CDS             complement(20135..20857)
                     /locus_tag="VVO18_000588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397198.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEU5585791.1"
                     /translation="MRLDKFLVACAVGSRTEVKNLLKAGRVTVNGKKEKSAKLQIDEK
                     IDEIRFDGQVLEYEEFVYYMMNKPKGVISATEDPKHRTVLDLLDDLARSKEVFPVGRL
                     DIDTHGLLLLTNDGQLAHVLLSPKRHVDKTYLAQVKGIMTQEDVETFAEGIPLKDFTC
                     QPAILELVSIDTEKNQSQIRVTIAEGKFHQIKRMVGYCGKEVVDLQRLTMGTLVLDEN
                     LERGEWRRLTKEELEILRANII"
     gene            complement(21080..21310)
                     /locus_tag="VVO18_000589"
     CDS             complement(21080..21310)
                     /locus_tag="VVO18_000589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000901571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEU5585792.1"
                     /translation="MLGSMFVGLLVGFLAGAMTNRGERMGCFGKMFLGWIGAFLGHLL
                     FGTWGPVLSGTAIIPAILGAMIVLAIFWRRGS"
     gene            complement(21320..22561)
                     /locus_tag="VVO18_000590"
     CDS             complement(21320..22561)
                     /locus_tag="VVO18_000590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminopeptidase"
                     /protein_id="HEU5585793.1"
                     /translation="MVLPNFKENLEKYAKLLVANGINVQPGHTLALSIDVEQRELAHL
                     IVKEAYALGAHEVIVQWTDDVINREKFLHAPMERLDNVPEYKIAEMNYLLENKASRLG
                     VRSSDPGALNGVDADKLSASAKAMGLAMKPMRIATQSNKVSWTVAAAAGLEWAKKVFP
                     NAASDEEAVDFLWDQIFKTCRVYEADPVKAWEEHAAILKSKADMLNKEQFSALHYTAP
                     GTDLTLGLPKNHVWESAGAVNAQGEEFLPNMPTEEVFTAPDFRRADGYVTSTKPLSYN
                     GNIIEGIKVTFKDGQIVDITAEKGDQVMKDLVFENAGARALGECALVPDPSPISQSGI
                     IFFNTLFDENASNHLAIGAAYATSVVDGAEMSEEELEAAGLNRSDVHVDFMIGSNQMD
                     IDGIREDGTRVPLFRNGNWAN"
     gene            complement(22583..22735)
                     /locus_tag="VVO18_000591"
     CDS             complement(22583..22735)
                     /locus_tag="VVO18_000591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776615.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585794.1"
                     /translation="MKLRIFAEDKPAKKVFEYQLELADRTILLSTALLPGAIALAGIF
                     SALKEK"
     gene            complement(22756..23034)
                     /locus_tag="VVO18_000592"
     CDS             complement(22756..23034)
                     /locus_tag="VVO18_000592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013904578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system YafQ family
                     toxin"
                     /protein_id="HEU5585795.1"
                     /translation="MLKIRYHKQFKKDFKLAMKRGLRAELLEEVLNFLVQEKEHPARY
                     RDHSLTASKHFQGVRECHTQPDWLLVYKVDKSELILNLLRTGSHSDLF"
     gene            complement(23027..23290)
                     /locus_tag="VVO18_000593"
     CDS             complement(23027..23290)
                     /locus_tag="VVO18_000593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelB/DinJ family
                     antitoxin"
                     /protein_id="HEU5585796.1"
                     /translation="MSKMSISIRLDSEVKEQAQQVFSNLGMDMTTAINIFLRQAIQYQ
                     GLPFDVRLDENRKLLQALTDLDQNRNMSQSFESVSDLMEDLRA"
     gene            complement(23392..27783)
                     /locus_tag="VVO18_000594"
     CDS             complement(23392..27783)
                     /locus_tag="VVO18_000594"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PolC-type DNA polymerase III"
                     /protein_id="HEU5585797.1"
                     /translation="MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFH
                     FVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGP
                     CASQGFKFLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQ
                     VEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPVFDFQAKKA
                     AAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSM
                     QKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPE
                     GERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKA
                     GIQLIYGMEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKM
                     YKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVA
                     HNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEH
                     HHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKN
                     QVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVD
                     AAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGN
                     VHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFL
                     GEELARKLVIENTNALAEIFEPVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPL
                     PDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGI
                     TEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLG
                     FDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERD
                     YGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQ
                     TTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVL
                     GVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQD
                     LIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIE
                     AMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAK
                     AFDIKTMGAGLEVIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLD
                     LYRSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSST
                     LVEKMDEMGILGNMPEDNQLSLFDELF"
     gene            complement(27887..29968)
                     /gene="fusA"
                     /locus_tag="VVO18_000595"
     CDS             complement(27887..29968)
                     /gene="fusA"
                     /locus_tag="VVO18_000595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor G"
                     /protein_id="HEU5585798.1"
                     /translation="MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETH
                     EGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGA
                     VTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAH
                     PIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAV
                     AETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVID
                     YLPSPLDIPAIKGINPDTDAEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVL
                     QSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEK
                     SKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVIS
                     GMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDV
                     WIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLY
                     DGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTA
                     RRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQ
                     EEIIKKNKGED"
     gene            complement(30393..30863)
                     /gene="rpsG"
                     /locus_tag="VVO18_000596"
     CDS             complement(30393..30863)
                     /gene="rpsG"
                     /locus_tag="VVO18_000596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S7"
                     /protein_id="HEU5585799.1"
                     /translation="MSRKNRAPKRDVLPDPLYNSQLVTRLINRVMLDGKRGTAASIVY
                     GAFEQIKEATGNDALEVFETAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLR
                     WLVTIARLRGEHTMQDRLAKEILDAVNNTGAAVKKREDTHRMAEANRAFAHFRW"
     gene            complement(30883..31296)
                     /gene="rpsL"
                     /locus_tag="VVO18_000597"
     CDS             complement(30883..31296)
                     /gene="rpsL"
                     /locus_tag="VVO18_000597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002356190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S12"
                     /protein_id="HEU5585800.1"
                     /translation="MPTINQLVRKPRKSKVEKSKSPALNVGYNSHKKVQTNVSSPQKR
                     GVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLLRGGRVKD
                     LPGVRYHIVRGALDTAGVNDRKQGRSKYGTKRPKA"
     gene            31713..35510
                     /gene="spuA"
                     /locus_tag="VVO18_000598"
     CDS             31713..35510
                     /gene="spuA"
                     /locus_tag="VVO18_000598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored pullulanase SpuA"
                     /protein_id="HEU5585801.1"
                     /translation="MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISS
                     DESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPRNANASLEKTEEKPATEPT
                     TSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDDVEKPSENWPNGALSF
                     KDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVEKLVPKMNEAWLDQDY
                     KVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQWPDGTDFTATGKYGRY
                     IDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQIFLKDDDESIYTNPY
                     YVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHLGNKVTITDVAIDEAG
                     KKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGKLGADLKEEGKQVDLT
                     LWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTNKLGITDFTGYYYQY
                     QIERQGKTVLALDPYAKSLAAWNSDDAKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHN
                     FKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVL
                     SYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLI
                     NEIHKRGMGAILDVVYNHTAKVDIFEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMT
                     KRLLVDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYA
                     GDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKN
                     LIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNL
                     MVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHLLRDKDGNPFDYPYFI
                     HDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDR
                     VHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKAREFNLGTAFAHLRNAEV
                     LADENQAGSVEIANPKGLEWTEKGLKLNALTATVLRVSQNGTSHESTAEEKPDSIPSK
                     PEHQNEASHPAYQDPAPEARPDSTKPDAKVADAENKPSQATADSQAEQPAQEAQASSV
                     KEAVQNESVENSSKKNIPATPDRQAELPNTGIKNENKLLFAGISLLALLGLGFLLKNK
                     KEN"
     gene            complement(35610..36659)
                     /locus_tag="VVO18_000599"
     CDS             complement(35610..36659)
                     /locus_tag="VVO18_000599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000229779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="HEU5585802.1"
                     /translation="MVELGISTFGEITELEGTGQTYSHAERIRQLVAEIELADKVGLD
                     VYGIGEHHRADFAVSAPEIVLAAGAVNTKKIRLTSAVSILSSMDPIRLFQQYATIDAL
                     SNGRAEIMAGRGSFTESFPLFGYDLKDYDSLFDEKLDLLQLVNEKTKLDWQGRLTQTI
                     AGKEVYPRPVQDKLPLWIATGGHVESTVKIAQAGLPIVYAIIDGNPRYFKKLIQAYRE
                     IGSEAGHADKDLKVGAHSWGWIAEDGEQAVKDYFHPTKQVVDAISKDRPHWQELRYEQ
                     YLDQVGSNGAMFVGNPDQVAEKLIRMIEDLGLDCFMLHLPLGSMPHDQVLRAIELFGT
                     QVAPKVRAYFAMKEA"
     gene            complement(36778..38586)
                     /gene="glmS"
                     /locus_tag="VVO18_000600"
     CDS             complement(36778..38586)
                     /gene="glmS"
                     /locus_tag="VVO18_000600"
                     /EC_number="2.6.1.16"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014621492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="HEU5585803.1"
                     /translation="MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHL
                     VKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIE
                     NYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
                     VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADS
                     VEVQDYDGNRRERASYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQ
                     VVVDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPVELGISSEWGYGMPL
                     LSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGP
                     EIAVASTKAYTAQIAALAFLAKAVGEANGNAKAQAFDLIHELSIVAQSIESTLSEKET
                     IEAKVRELLETTRNAFYIGRGQDYYVAMEASLKLKEISYIQCEGFAAGELKHGTIALI
                     EEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTTVHPYLS
                     PISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE"
     gene            complement(38778..40157)
                     /gene="bglA"
                     /locus_tag="VVO18_000601"
     CDS             complement(38778..40157)
                     /gene="bglA"
                     /locus_tag="VVO18_000601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000943526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HEU5585804.1"
                     /translation="MLRFPKDFVWGSSTSGPQTEGRVAGDGKGDNLWDYWFQVEPNRY
                     YNGIGSDKTSTFYENWERDIELLLETGHTVFRTSIQWSRIFPQGCGKVNPQGVDFYRK
                     VFEAIKAKGICLLVNLYHFDLPFALQEDGDGWENKATVSAYEDYARFCFETYGDLVDQ
                     WITFNEPIVPVEFGYFYDAHYPHKVDAEAAVKVAYHTQLASSRAVKACHELLPDSKIG
                     IVLNLTPAYPRSQHPADVKAARIAALFQAQSFLDPSVLGTYPQELVEILHEHGLLPDA
                     TEEELELIRDNTVDFLGVNYYQPLRVMAPRFAKHPESPLLPEHFYEPYVMPGRKINSH
                     RGWEIYEQGIYDIAQNIKENYGNIEWMLTENGMGVEGEEKFRQDGMIQDDYRIDFVKG
                     HLRELHRAIEDGANCKGYLIWTFIDCWSWLNSYKNRYGLVELDLETQERRLKKSGHWF
                     KKLSDNNGF"
     gene            complement(40257..42110)
                     /locus_tag="VVO18_000602"
     CDS             complement(40257..42110)
                     /locus_tag="VVO18_000602"
                     /EC_number="6.1.1.15"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="proline--tRNA ligase"
                     /protein_id="HEU5585805.1"
                     /translation="MKQSKMPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLP
                     LANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKS
                     DFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDA
                     YSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSART
                     DLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATN
                     EYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVG
                     NDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVR
                     NAVVGANEDGYHLTGVNPGRDFTAEYVDIREVREGEISPDGQGVLNFARGIEIGHIFK
                     LGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRY
                     AWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKF
                     SDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK"
     gene            complement(42123..43382)
                     /gene="rseP"
                     /locus_tag="VVO18_000603"
     CDS             complement(42123..43382)
                     /gene="rseP"
                     /locus_tag="VVO18_000603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RIP metalloprotease RseP"
                     /protein_id="HEU5585806.1"
                     /translation="MLGILTFILVFGIIVVVHEFGHFYFAKKSGILVREFAIGMGPKI
                     FAHIGKDGTAYTIRILPLGGYVRMAGWGDDTTEIKTGTPVSLTLADDGKVKRINLSGK
                     KLDQTALPMQVTQFDFEDKLFIKGLVLEEEKTFAVDHDATVVEADGTEVRIAPLDVQY
                     QNATIWGKLITNFAGPMNNFILGVVVFWVLIFMQGGVRDVDTNQFHIMPQGALAKVGV
                     PETAQITKIGSHEVSNWESLIQAVETETKDKTAPTLDVTISEKGSDKQVTVTPEDSQG
                     RYLLGVQPGVKSDFLSMFVGGFTTAADSALRILSALKNLIFQPDLNKLGGPVAIFKAS
                     SDAAKNGIENILYFLAMISINIGIFNLIPIPALDGGKIVLNILEAIRRKPLKQEIETY
                     VTLAGVVIMVVLMIAVTWNDIMRLFFR"
     gene            complement(43404..44207)
                     /locus_tag="VVO18_000604"
     CDS             complement(43404..44207)
                     /locus_tag="VVO18_000604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatidate cytidylyltransferase"
                     /protein_id="HEU5585807.1"
                     /translation="MTQDLQKRTLFAGIALAIFLPILMIGGLLLQIAIGIIAMLAMHE
                     LLKMRGLETMTMEGLLTLFATFALTIPLENYLTFLPVDGNVVAYSVLISIMLGTTVFS
                     KSYTIEDAVFPLAMSFYVGFGFNALLDARVAGLDKALLALCIVWATDSGAYLVGMNYG
                     KRKLAPRVSPNKTLEGALGGILGAILVTIIFMIVDSTVALPYGIYKMSVFAIFFSIAG
                     QFGDLLESSIKRHFGVKDSGKFIPGHGGVLDRFDSMLLVFPIMHLFGLF"
     gene            complement(44216..44974)
                     /locus_tag="VVO18_000605"
     CDS             complement(44216..44974)
                     /locus_tag="VVO18_000605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoprenyl transferase"
                     /protein_id="HEU5585808.1"
                     /translation="MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFG
                     HKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPEL
                     HANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLI
                     SQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYS
                     ELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV"
     gene            complement(45205..45777)
                     /locus_tag="VVO18_000606"
     CDS             complement(45205..45777)
                     /locus_tag="VVO18_000606"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001098890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase family protein"
                     /protein_id="HEU5585809.1"
                     /translation="MNTVKNKQEILEAFRENPDMMAILTIIRDLGLKDSWLAAGSVRN
                     FIWNLLSDKSPFDHETDIDVIFFDPDFSYEETLLLEKKLREDFPQYQWELKNQVYMHQ
                     HSPHTASYTSSRDAMSKYPERCTTVGLRLNEESDFELYAPYGLEDILNFQVRPTPHFL
                     ENEDRMELYQTRLSKKNWQEKWKNLIFKNT"
     gene            complement(45758..46729)
                     /gene="ruvB"
                     /locus_tag="VVO18_000607"
     CDS             complement(45758..46729)
                     /gene="ruvB"
                     /locus_tag="VVO18_000607"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000502070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="HEU5585810.1"
                     /translation="MGDEELVERTLRPQYLREYIGQDKVKDQLQIFIEAAKMRDEALD
                     HVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPVIEKAGDLVAILNELEPGDVLFIDE
                     IHRLPMSVEEVLYSAMEDFYIDIMIGAGEGSRSVHLELPPFTLIGATTRAGMLSNPLR
                     ARFGITGHMEYYAHAGLTEIVERTADIFEMEITHEAASELALRSRGTPRIANRLLKRV
                     RDFAQIMGNGVIDDIITDKALTMLDVDHEGLDYVDQKILRTMIEMYSGGPVGLGTLSV
                     NIAEERETVEDMYEPYLIQKGFIMRTRSGRVATAKAYEHLGYEYSEK"
     gene            46890..46982
                     /locus_tag="VVO18_000608"
     CDS             46890..46982
                     /locus_tag="VVO18_000608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269759.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="HEU5585811.1"
                     /translation="MMELVLKTIIGPIVVGVVLRIVDKWLNKDK"
BASE COUNT        14357 a        10596 c         8988 g        13686 t
ORIGIN      
        1 aaggataatt caggttacga aaaaattatt agaagtgcga ttttaaaata tgaattagat
       61 aatcaaaacg gtcgtattat cattaaagcg cttatcagag gtgacgaatt tagtaaaaag
      121 gttcagacac ttgacgatgt attagctgga gttctagaac ttgaactaga agaaaaaatt
      181 actcatccta atattgtgga atatcacttt tattacaaga aacctgatag actaatatta
      241 tcaccccatg atcataaaaa agagatagat agtcttgata tagacttagg atatgatata
      301 acttataatc ctataaaatg ccctcatatt ttagtttcag gtggtacagg tagcggaaaa
      361 tctatattta tatctttctt aattattgaa cttcttaaaa gaaattcaac actatatatt
      421 gcagatccta agaacagtga tttaggtagt ttatctcatt atttaagcga taaatatgta
      481 gctacaaccc ccaatagtat tgctcgtatt gtacgtttag tagttgaaca aatgcaggca
      541 cgatatcaaa ccatgcgtga taactttcat tacggatcaa attttgccga ccatggcttt
      601 aaaccagtat ggcttatatt tgatgaaatg ggagcatttc aagcttcagc aacagataaa
      661 aaatctaaag aagttatcac cgaagtaatg gacggtatca aacaaattat cctactaggg
      721 cgacaagcag gagtatttat tcttatatct gctcaacaaa tgagagctga aactctaaac
      781 actgatctta gagataattt aggactgaga atagctttag gagcaaactc aatagaggga
      841 taccgcatgg tatttggcac ggccacacct gataagttta aatctattga agaaaaagga
      901 gcaggatatc tttatatgca gggctcaggg aaagaaaaag ctcaatattg ggaaagtcct
      961 tatcttgata caacgcaatt cgattttata aaagaactac aattatacgt aacaaagtca
     1021 aaataatttc aatagatatt tttgcttaaa ttcaatagat tttcagcaaa aatatctatt
     1081 cctcatcgct taagcgatga caaaaagaaa cgaggtatta tacgaaaatt aacgattttc
     1141 ttaaaccaga attattggga aataaattcg tggcagtaaa aggatataca gaagttttgg
     1201 acagagaaac aaataaacct gtagcactac gtcttaatgt ttcaattcaa gatgaggatt
     1261 ctgatttctt tatggaaatg atccagataa aagttaatac gttatctcct acggctactc
     1321 ctcaattatt atcagataaa aaaacatgcc ccattaaatt atctaattta acagttggac
     1381 aatttaacgg aaatttatgg ttttcttgta acgatgtagt ccctatttct aaataattcg
     1441 gtgatactat ttatggctaa actttttgca atatctgata tacatggtca cctagatgag
     1501 ttcctatccg ctctcagtaa agtagattta tctgataaaa ataatcgtct tattttaatc
     1561 ggagactata ttgacaatgg acatcaatct tttcaagtta tttccaaaat aattgaactt
     1621 gaggaacttc atcctaatca aattattact cttttaggaa atcacgaaga atggttttat
     1681 gattggttga ttttagaaaa tcctacttct tcttcatttt cggaaacaat aaaaagtttc
     1741 ttctctccag aggaattgac ctatatttta aaatctaatg ttaacaactt tgaagcaggt
     1801 gttagaaatg aaattaaaaa taatatcaag ttcaacccat tcataaactg gtttaaaaaa
     1861 cgatataggg ataaacgcta ttatgaaact gatacccaaa tttttgttca tgctggtatt
     1921 gatgaagaag ctggcaagct ttggaaagac ctaacgagtt cagagatgtt tacaaataaa
     1981 tttcctatta ccactggtgg attttttaaa gatattgttt ctggtcatat tgcttcttgg
     2041 gaagtagcta aagataaaac ttatcagggt aagatttact ttgatggtaa aaatcattac
     2101 ttcattgacg gcgatgtgta tcatagcaaa acaatacctg ttatctgcta tgatacagtt
     2161 acaaaatcct atcaatatta aataacattc taaaaaaatt gatagaattt aattctattc
     2221 ttagactaat atcaaaaata atgaggggaa tctatatgaa gacattatta attggcgact
     2281 tacatttaaa atctcaacta attttaccta ttgttgacag gattatccaa acacataata
     2341 ttaaaagagt catttttctt ggtgattatg ttgatttaca tggacaaact aacaatatcc
     2401 aactatatgc caaagatctc acttttttat actcttggaa aatagataaa gagcaaaatg
     2461 gaatagaggt aattaatctt ataggtaatc acgatgctta ttatttattg ggagatcaag
     2521 ctcctttctc aattcaaaat ttagaagtgt ttttcgcagt tcaaggattg ttgcaggatt
     2581 taaaattaca agtggcttat caactagatg attatttaat cagtcacgct ggtttcaatc
     2641 agatatttga tcctcaaaaa tggcatttta ccccctacac caaagagcat gaagaagaat
     2701 tagatattct agcttataca ataggaccaa tgcgtggtgg ggaagctctt gggggttctc
     2761 ctttatgggc acattttaga gaattagaac tgcttcccaa ccaagacttt cctaaacaaa
     2821 ttgttggaca tactccgaaa gaatctattg atatttctaa aaatgttatt ggtatagata
     2881 ctttttcatt atatattgac aaagataata aatatcaatt tattggtaac ggtgatttgc
     2941 tagtctatga ccaaggccat cttgaaatca tttcaaccaa ctgggctaca gacgaaacat
     3001 taaaacaatt acctaaacca caaatttaac tactacttct catcatgtga ctaagcgaaa
     3061 ctgctgactg gaggtcggca agctggaagc gtgtttagcg gagcgatgct tagaaacaca
     3121 tgatagaagt acggaggagc tttgctcctc ctagtttatt tattatataa gcaaacatta
     3181 cgagaaaagg agatgatttt gtgagttaca atcgcaaaat tatccgaact tcttcgtacc
     3241 ttgaaatatg ggaatacgaa tctccaattt tttcaaatga tactactcaa attgatgaag
     3301 aacacatttc actaaaagaa aagaagaaac gtagaacttt tgaagaactc acaactgctg
     3361 aacaagatga acgaataaaa agaatttcta acactcgtaa aaattctaaa tggaaacttc
     3421 aacgcctaat agatacaaat tttgatgaca gaactagttt ccttaccctt acaaccaaag
     3481 aaaatataca aaacagatat gagtttaatt tactttttga taaatttatt aaacgtttaa
     3541 actatcacat gtaccattca aaaaaaagac ttattaaata tattgcagta ttagaacgac
     3601 aaaaaagggg agcgtggcat gcacacattc tccttttttc atttcctttt atccctcata
     3661 aagaattact gacaatttgg gggttaggtg cagttcggat aaacaaacta cataacttag
     3721 atgattcttc taatgctggt cgttatgttg gaaaatatat ggaaaaaggc ataggacagg
     3781 aattattaga gagtctagga aagaaggctt tttattcttc tcgtaattta caaaagcctg
     3841 aagaaataaa attatttaca agtgaatcct tagataacct tgttaagaat gaagatatcc
     3901 tatatgaaag caactatatt agcaaagtat ttcgaaaagg acacttaatt gacaataaag
     3961 taaaatacaa aaaaataaag ttaagtaagg agtaaggaaa aaatgcaagt tattctacca
     4021 acagaacaag ttcaagaaat acagtcgatg attactaatc tcttgcaaaa tgaaatttct
     4081 catttcaaag aagatttagg tttagatagt ccttacctta acaaggggca aacttgcaaa
     4141 tatctaggga tatctaacaa tacattagat ggctggatac aaaaggggct acccgttatt
     4201 aaaattggta agactgtccg tttcaataaa aatgagattg ataaatggct ttgtagaaaa
     4261 gctatgctat aatatctcta atgatatatc ctgactcgta aaaggagaac atcatgacag
     4321 ttacaaaaac aaatagtaac acttacaatc ttaaagtgta tatacctaaa gaaatccgac
     4381 ctaaaatggg gattaaagga aatcactttg ttaaacgcta taaaacaaga aaggaggcca
     4441 aagaagctga actagaaatt ttaactaaga tacatcaact tgaaaatggt gaggatatcc
     4501 tactttctaa aactaacgat attctattct ctgagttctt taataatatt tggtgggatt
     4561 catacaaagc tggtcaaaca acttcaacaa ctagaccacc aacacaggtt actattgata
     4621 atactaaaac tgttttcaga aagcatatct taccaatgtt cggtaattat tcaatcaatt
     4681 ttctgaatca gaataagcaa gtcgtactaa acttaatgac tgctaaagct gaagaatatg
     4741 ctaatttcaa ggttattcga agttatgtaa actcaatttt cgattgggct gaggaattag
     4801 agtacataga atcaaatcga ttatccaaga caattaaacg aattaaagct accaaaaagc
     4861 taaaactcca agaatccaaa aatgaggaag atttgtatct atctagtgaa gaattacaag
     4921 attggtttga tgcttttaga gaagatttgg agaacgataa attatcacta aaagattatg
     4981 tcctattctt tacaaccttt attctaagcg atagaaaatc tgaatcctat gccctacatt
     5041 ggaaaaacat agacttagaa aacgctcaaa ttgacttaag gcatgcactt gacaaatata
     5101 agaatgtaaa gtcaacaaaa ggaaataaga aaacgatttt ttcaattcct agttaccttg
     5161 tatcacttct ttcagaatgg aaaaaacagc agaaatatga gttagcgaaa tttggtataa
     5221 tgcaaacatc cgatcaacta gtctttacct atatagatac gaaaggtaat gtaaatagcc
     5281 ctctacacgt tgattatctc aataacaaaa tgaactctgt taaaagacga cacccaaagt
     5341 taaaacacgc tacacctcat aaattacgac atactggagc gacacttgct aaaaaagcag
     5401 gaatgagctt agaagccatt tctgaagcat taactcatag cgatacaatt acaacgaaga
     5461 cttatgttaa tacttcaaac atagttccat tatctgctgg acaagttgcc taccaacatc
     5521 ttaaaaacaa gtagggaaaa tttagggcaa attttagggc aaacttttgt agaaagtata
     5581 gaaaaaagca cccatagggc aaacctgtga gtgcttcgaa acgttgatat aatcgagttg
     5641 attaacgttt tgagaattgt gatgctttac gagctttctt aagacctggt ttcttacgtt
     5701 caactttacg tgagtcacgt gtaagaagtc ctgcgcgttt caatgaatcg cggaagtctg
     5761 ggtctacttg aagaagggca cgagcgatac cgtgacggat agctcctgat tgaccagcgt
     5821 atccaccacc tataacgtta acgaaaacgt cgtatgaacc tacagttgaa gtaactgcga
     5881 atggttggtt gatgacaaga cgaaggtcag cgtgtgggat gtactcttca acatcttttt
     5941 tgttaacagt gattttacca gttcctggaa caaggcgaac gcgtgcaaca gcgtttttac
     6001 gacgtccagt acctgcatat tgtgcttgtg acatacttta ttgttccttt ccttagataa
     6061 gtcctgaaat gtcaagaact tctggttgtt gtgcagcgtg agtgtgctca gctccaacaa
     6121 atactttcaa cttcatacct tgagcgcgtc caagtgtatt gtgtggaagc atacctttaa
     6181 ctgatttctc aatcaaacgt actgcatttt tagaacgaag ttcacctgca gagatttgtt
     6241 tcaatccacc tgggtggttt gagtgagtgt agtagatttt atcagttgct tttttaccag
     6301 tcaatttaac tttttcagca ttgataacaa tcacgaagtc acctgtatca gtgtgtggtg
     6361 taaatgttgg tttgtttttt ccgcgaagta cgctagcaac tactgcagaa agacgtccaa
     6421 gtggtacatc agttgcgtca actacgtacc atttacgttc aacttggcct ggtttagcca
     6481 taaatgttgt tttgttcatg atttctccta tatatagttc gatttttgtt tacggtgatg
     6541 ggtgttcctt cccatcgaaa agtatttgga aggttccggg gcctttcaaa tggggtaaac
     6601 aataccgcct actatcatac caaatttcac ccctaaaagt caatagatat aaaaaatatt
     6661 tttcggtaac ttctcaaaat aactgaaagt tatataatca agttaatttg ggaatttacc
     6721 tattaacttc ggtagatttt tgggaatttt ttccctattt ctccctgtaa ctaaaatcct
     6781 tttcaaaaaa tcaccttttc ttgattttta atcctatttg ctgtatgata agggaaaaga
     6841 aaggggacag agatatggct tttaccaata cccacatgcg gtctgctagt tttggcattg
     6901 ttaccagctt gcccgatgac atcattgact ctttttggta tatcatcgat catttcttaa
     6961 aaaatgtctt tgaattggaa gaagaactcg agtttcaatt gcttaataac caaggaaaga
     7021 ttaccttcca cttttcaagt caacacctcc ctacagccat tgattttgac tttaaccatc
     7081 ctttcgaccc tcgttatccc ccaagagtac tggttttaga catggacggt agagaaacta
     7141 tcctcctccc agaagaaaat gacctatttt aaaaactcta gccttcagtt gcaagtaact
     7201 gaaaactaga gtttttctat tttttcaaag catcatacaa gttgcggatc ggttgtttta
     7261 atatcggatg gataaaatga ggcgcaattt cctgtaagga ctcaaggaca aaaaggcgtt
     7321 ccgctatgta aggatgaggc aatatgaggt cgtctgtata aaggatctgg tcctccacaa
     7381 agagcaagtc caaatcaatc aaacgaggtc cccaatgcac ttctctcacc cgtcccagct
     7441 ctgactcaat ggctaacaag gtttctaaca agtcttgtgc tggtagccag gtttccacct
     7501 caaccacttg attggcaaag ctatcctgct ccactccacc ccaaggctcc gtctctaaga
     7561 cactggactc tttgagaata tggatgccac gagctcgcag tttgtcaatg gcttgcttca
     7621 agtttacttg tttatctccc atattgcttc ctagggcgat aaaggctcgt tgcttgcggc
     7681 gatgaatggt taccgagcaa gtatctagtg acaaatgcac cggtgcccaa ggttttttca
     7741 gttccaactt catttcttgg acaagaggat aagactcaaa ggtacgttcc accagtttat
     7801 aggctaccgt ttcaatcaaa tcttcactcg tttcctgaaa ccaagtcgtc cactgctgac
     7861 acaattctcc gtaatggaca gaggctgtta aatccaagtc tgtagctgcc ttggtcatat
     7921 cataggatag gatggctgaa acgacaaatt tctgccccaa ttctttctca ctaggaaaaa
     7981 gaccatgata ggcaaacatt tccaaatcct taatctgcag ttgatccata atgattcctt
     8041 tctagaaaaa tccgcttgaa gcggattctt tttatagccc cattaaacga taagcttggt
     8101 cacggagatc cttatctgtt tcaaatagac cacgagctac tgtcgtcaag gttgcagtgc
     8161 ctggttttct aacaccacgc atactcatac acatatgttc cgcctcaatg acaacaaagg
     8221 ctcctttagc acctagatag tccatcaagg catcggccac ttcgatattc aaacgttctt
     8281 gaatttgtgg ttttttcgaa taaacttcaa ccgtacgggc tagcttagac aagcctgcca
     8341 cacgaccatc tggaatgtag gcaatgtgcg ctctaccata aaatggcaag aagtggtgtt
     8401 cacacatggt atggaaaaag atatcctttt ctaccaccat attatcgtca ataatttcaa
     8461 aggattttga caaatgttcc tctgctgttt gaccaagacc tgaaaaaatc tcttgataca
     8521 tacgggctac acgagcaggt gtttcctgca agccctcgcg attaacgttc tctcctacag
     8581 cctcgataat catttttaca gctgcttcaa tcttttgtgt atccattctc gttcttcctc
     8641 tccatcagat aggccctcac ttggctcaag aaatacaagg aacctgtgac aatcctaact
     8701 gtttgtttct cttctttttt atctgtcaaa ttctgatcta gaaaatcatg ccaatcttgg
     8761 tagctgagat ttctagactt agctgcctct ttcagcacgc tttcatccgt cgcccgacta
     8821 tccgcaaaat gtgttagagt aagctcggta tctggcatgg ctcccagcaa gtccaacata
     8881 tcctccaagg ctttggtttt gatacaagtg aagaggattt ccttatgatg atccgcaaaa
     8941 cgttcttgca aggttaccaa caaggccttg atagcatggg gattatgggc tccatccaaa
     9001 atcatcaagg gatctcttga cacgatttcc aaacgccctg gccaacttgt ttcttccaag
     9061 gcttgaccaa gcaggtcatt gcttactagt tctcgaccat cttctttaca aaaagtatca
     9121 agtaaagcta tggccatccc agcattctct atctggtgta aaccaagcaa acctgtctgg
     9181 aagcgacctt gtctgagaga actagtatag tcaaagactt cacccgttac cacattctct
     9241 tggtgactga catgataatt tgccccatag gcaagtctcg gcgcatcttt cccttccgca
     9301 atgcagtcaa tcacagccaa ggcttctgga gcgatatgac ctgtcaccaa tggaattcct
     9361 tgtttgataa tacctgcctt ctgctctgct atggcttcca aggtgtcacc aagtagggct
     9421 acatggtcca atccaatagt cgtaattcct gtcaaaatgg gctgacagac attggtacta
     9481 tctaaaagtc cacccatgcc gacttccatg atagccacat ctacttgctc tgaagcaaag
     9541 tagtcatagg ctatggctgt gataatctca aactcggttg tgccctgtaa attagcggcc
     9601 gcttctccct ccagcaaaga ctgatagtct cccatgagag cttccagtct agcctcggga
     9661 atagattccc cattgatgct aatctggtct gtgtaatgaa tgagataggg cgaactgaaa
     9721 acaccaactc tcagccccat cttttctagc atatttttca aaaaagcaat ggtcgaaccc
     9781 ttaccattgg tccctccgac atggatgacc ttgagtttga gatggggatt tccacgcaaa
     9841 gctaacagtt ccaccattcg ttctaagcca aaatgcggtt gatccgtccg atagtgggca
     9901 atccactgat tattttcaaa ttctttcatc ttatttatat tgttttaaat ctagattttc
     9961 cgcttcatca gccagacgaa tggcggaggc aatttcaact gccatcctgt gactagctac
    10021 gtcatgcacg cgcaccactt ccacaccctg tctcgcagcg atactggtta catgagccga
    10081 agctgtgtcc cgattgtgga aaccaagttc tgtctcagga ttgacttcaa aaccattttc
    10141 ttcaaggata ttgatgacaa acctcttgcg cgacactcca agaaagattg gatagccctt
    10201 ctgatgtagt ttatccaggt ctcgtaaaag aagcaaattt tctttcttag tcagcccaaa
    10261 gccgattcct ggatccaaca ggatattttc ttgtgcaatt ccagcttgat ttgctctcgc
    10321 tagtgctctt tcaaagaaag tctccatcaa ctcttcgatt ggcaatgttt caaagtcagc
    10381 taactcttcc tctgtaaaag cttgattaaa tccaaaatga gggaatatga gcgagctagg
    10441 atgctgaggt cgagccataa caggattaaa cataatgacc actttcgctc catctttagc
    10501 tatcacatgg gccatttttt catcacccat gagaccagtg atatcattga ctagattggc
    10561 accagcagcc aaagcagcct ctgcaacctg acttttccaa gtatcaatag aaatgaggac
    10621 atcactttcc ttgcgaatcg ctttaatcac tggaacaaca cgctggatct cctcttctat
    10681 ctcaacataa tagctacttc ccggccgagt tgattctcca ccgatatcta gcatgctagc
    10741 cccttctgct atcaatttac gagcctgctg gagtgcctgc tcaagagcaa aaaattgacc
    10801 accgtccgaa aaggagtctg gggttacatt gataattccg caaatagctg tctttgcacg
    10861 attggcttta cttaacatat cggtcactcc ctcaaggctt ttcaccatat tatttctcta
    10921 ttttaccata aaaagaaaaa aatggacacg attgcattca tctttttccc agtagaaaca
    10981 tgtaagcaat tgtcaaaaat cttaaacaga aatccctaat gtccgactca tgatcaccac
    11041 aagagccaac aaacagaaag caaccccatt cacaatcatg tgaagtagga tagacatttc
    11101 caaacgttgg gtcttgtaag ccgtccaaga cagaacgatc gacatacctc cataaatcaa
    11161 taaagaaggt aaattacttg gttgatgcaa taaagcaaac acaatcgtac cgactacaaa
    11221 tcccaagttc tccttgcctc gaaaaatctt tttaggaaca atcccacggc acaagatttc
    11281 ctcacaaatc ggagcaagca aggctagcaa gaagaagcta gaaatcagag aactattctg
    11341 aaccatatca ttaatctgag actggttagc tgttgtcgtc tcatttgaca gttgcaataa
    11401 aatagaacca agtatatttg aacagataat gactaaataa cttaatccca atcgtgctag
    11461 atccttagct ctaaaaaaag aaaaattaaa acttgctaat tgcgttttac gagctccaat
    11521 aataaatagc accagaacca caatcgaaat accagtgact atcagtcctg actgtaacag
    11581 aggtactgca tttaaagtca aaatagcagt aacccctata ggaatctgat ataaaattgt
    11641 cgctagcaag aagaccaaaa gccatactgc acgattcaac aattctttcc atatattttt
    11701 ctctttcatc acctatctcc tttgtattca aaaaggggga aaatccccct gggttatcct
    11761 attatagtgc catactgata tagttaagga taaacaaggc atccaaaatc caaatcatga
    11821 catgaacatc tttagcttga cctttgacaa gtttagtcaa agtgtaagtc aagaaaccaa
    11881 ctgcaatccc ttgagtgata gagtagctga atcccataaa gatagatgtg aagaaagcag
    11941 gaaccgcttc agccatatca tcccaatgga tatttttcaa gctagccaac atcataattc
    12001 cgacgataat caagattgga gctgtagcag ctgttggtac gatagcgaga agtgggctaa
    12061 agaagcttga gattgcaaaa cagattgcca cgaccaaggc tgtcaaacca gtacgtccac
    12121 ctgcaccgat accagcagca gactcaacat aagtcgttac gtttgaagta cctgcgatgg
    12181 caccaataga agtaccaatc aaatcagagt aaagagcctt gtccaactta gctgattggt
    12241 gattttcacc atttgttgct acgataccaa ctttttcacc agtaccgatt aaagtaccaa
    12301 ttgtatcaaa aatatctgtc aacgagaagg caagaattgc cataagagtt tctggtaagc
    12361 gagctgtatc tgaaatcaaa gctcccaaac cttctgaacc aagagctgca ccaaagattg
    12421 tcttcaaatc ttcaaaagct gcaccaacat ggttattagc aaaatcgata ctagacaaat
    12481 ctaccaaacc aactgcgata gcaagaacag ttgttgtcaa gatagaaaga ataattcccc
    12541 ctttaatccc cttgataaca aagaagatag taatggcaag tcctgcaaga gccaccaaaa
    12601 cagctggatt attaaagctg accaatcctg gaactgctga agagtttgct gcaatcgttg
    12661 cttgagcctt gtcagcccct tctcccacaa cagtatagtt gcctggatca atcgtaaatt
    12721 tcaaaagtcc agcattctta attcccacgt aggcaagaaa gacaccgata ccagctgaaa
    12781 tagctgagcg aagggcattt ggaatcgatt caatgatcat tttacgaaca tttgtcaagg
    12841 taataatcaa tgagataatc ccacagatga agaccatagc caaggcttct tgccaagaat
    12901 aaccaagtcc aaatacgacg gtgaaggtaa agaaggcatt cagtcccata cctggcgctt
    12961 gagcgtatgg caagttagca taaaaagcca tcatcaaggt acccgctact gcaccaataa
    13021 tcgttgcgag gaagacaccc tgagcaggca tccctgtttg cgaaagaatt tgtgggttta
    13081 caaagagaat atagctcatt gcaaagaaag ttgttaaacc agcgagaacc tctgtacgaa
    13141 cgtctgtacc gttctctttt agtttaaata atttgtccat tatcaatctc cttttaattt
    13201 ttacgaacaa tatctgtatt atatcattta tcattcactt tttcaatatc tttgtttaat
    13261 ttatttaaga aattgatgga atttcatttt ttgtttggaa tctgcttttc tgtctgcttt
    13321 ttgttataat agaagacatc ttatctggaa agacactaga aaggtttata tgacgaaaaa
    13381 aattattgca ctagatctgg atggaaccct gctcaactca gacagtcaga tttctgactt
    13441 taccaaagaa accattaaaa aagttactga aaaaggccat caggttatta ttacgacagg
    13501 tcgcccttac cgcatgtcaa aagattttta ccgtgaactg ggcttagaca ctcctatgat
    13561 taacttcaac ggatccctta ctcatttacc agaccaagtt tgggattttg aaaagtgttt
    13621 gactgtagac aaaaaatatc tgctagatat ggttcaacgt tcagaggaca ttcaagccga
    13681 ttttatcgct ggagaatatc gtaaaaaatt ctacattaca aatcccaatg aagaaattgc
    13741 caatcccaaa ctatttggtg tagaagcttt ccagcctgaa gatcaattcc agcctgaatt
    13801 ggtgaccaag gaccctaact gtatcctctt gcagaccaga gccagtgaca aatatgcctt
    13861 ggcaaaagac atgaacgcct tctaccagca tcaactttct atcaatacct ggggaggtcc
    13921 gctcaatatc cttgaatgta ccccaaaagg tgtcaacaag gcctttgctt tggactactt
    13981 gctcaagata atgaatcgtg acaaaaaaga tttgattgcc tttggagatg aacacaatga
    14041 taccgaaatg ctcgcttttg ctgggaaggg ttatgccatg aaaaatgcca atccagagct
    14101 actcccttat gcagatgagc aaatttccct taccaacgac caagatgggg ttgccaaaac
    14161 cctacaagac ttattcttat aacctatact gatactcaat gagaatcaaa gagcaaacta
    14221 ggaagctagc cgtaggttgc tcaaagcact gctttgaggt tgtagatgaa gctgacgtgg
    14281 tttgaagaga ttttcgaaga gtatgaccag cttgcaagct ggtctttgtg ctcttttcac
    14341 agtctcatca accagttaat cgattgttct actttttgtc tccaaaacct tggaaaaggc
    14401 ttccttttgt gatatacttc acatataaat acaagagagc tcgtcacact cgactctgtt
    14461 gacaaaaaat caatccagtc ccgttgtccc tgttctcggt caatatcaag gaggatagct
    14521 atgaaagctg ttgttgtaaa tccagaaagc actggtgttg ctattgaaga aaaagtactc
    14581 cgtccacttg aaactgggga agcacttgta gaagttgaat actgtggcgt ttgccacacc
    14641 gacctccacg ttgctcatgg tgactttggt caagtcccag gacgtgttct tgggcacgaa
    14701 ggtatcggta tcgttaaaga gattgctcca gatgtgaaaa gccttaaagt cggtgaccgc
    14761 gtcagcgttg cttggttctt tgaaggatgt ggcacttgcg aatactgtac aactggtcgc
    14821 gaaacccttt gccgtacagt gaaaaatgct ggctactcag tagacggtgg tatggctgaa
    14881 caatgtatcg caactgctga ctatgctgtc aaagttcctg acggacttga tccagcccaa
    14941 gcttcttcta tcacatgtgc tggagtaaca acctataaag ctatcaaaga agcaaaagtt
    15001 gaaccaggcc aatgggttgt tctttacggt gctggtggac ttggtaacct cgctgttcaa
    15061 tacgctaaaa aagtattcaa tgctcatgtt atcgcagtcg atatcaacaa tgacaaactt
    15121 acccttgcaa aagaagtagg cgctgacatt gtgattaacg gcctcgaagt tgaagatgta
    15181 gctggactca ttaaagaaaa aactgatgga ggagctcatt cagctgtcgt aactgctgtg
    15241 tctaaagttg ccttcaacca ggctgttgac tccattcgtg ctggtggtcg cgtcgtcgct
    15301 gttggtcttc cttctgaaat gatggaactc agcatcgtta aaacagtcct cgatggaatc
    15361 caagtcatcg gttctcttgt cggaactcgt aaagacttag aagaagcctt ccaatttggt
    15421 gcagaaggtc tggtagtccc agttgttcaa aaacgtccag tagaagatgc tgttgccatt
    15481 ttcgacgaaa tggaaaaagg ccaaatccaa ggacgtatgg tactcgactt cacccactaa
    15541 tttaatagaa acctatttta aaagttggaa gcttcttcca acttttttat attaaatttt
    15601 aaataagaat tcaagattac tcctcaaaaa ctcaacatat caacatacaa aaataaaaat
    15661 tttttaattt tttatgataa atagttgctt tttttatgaa aacggtttat acttaaacag
    15721 tcttaaagtt ttcttaaatg aaaactaaaa caaaaaagga ggaatgacaa taatgagtat
    15781 cggaatcatt attgcgagcc acggcgaatt tgctgctggt attcatcagt caggatctat
    15841 gatctttggt gaacaagaaa aggttcaagt tgtgaccttt atgccaaatg aaggtcctga
    15901 tgatctatac gctaagttta ataacgctgt tgctgcattt gacgcagaag atgaggttct
    15961 agttttggct gacctttgga gtggttctcc atttaaccaa gctagtcgcg tgatgggaga
    16021 aaatcctgag cgtaagtttg ccatcatcac aggacttaac ttaccgatgt tgattcaagc
    16081 ctacacagag cgcctcatgg acgctgctgc aggtgtagaa aaagtcgctg ctaatatcat
    16141 taaagaagcc aaagatggca tcaaagctct tccagaagag ctaaatccag ttgaagaagt
    16201 tgcaagcgct gcagctgctc cagttgccca aactgctatc ccagaaggaa ctgttatcgg
    16261 agacggtaaa ttgaaaatca atcttgcccg tcttgacaca cgtctacttc acggtcaggt
    16321 tgcaactgct tggactccag attcaaaagc aaatcgtatc atcgttgctt cagataacgt
    16381 ggctaaagac gaccttcgta aagaattgat taaacaagca gctccaggta atgtcaaggc
    16441 taacgtggtt ccaattcaaa aactgattga gatttcaaaa gacccacgtt ttggagaaac
    16501 acatgccctt atcttgtttg aaacacctca agatgccctt cgtgccatcg aaggcggcgt
    16561 gccaatcaag actcttaacg ttggttctat ggctcactca acaggtaaaa cattggtcaa
    16621 taccgttttg tctatggaca aagaagatgt tgctacattt gaaaaaatgc gtgacttggg
    16681 tgttgaattt gatgtccgta aagtaccaaa tgattctaaa aaagatttgt ttgacttgat
    16741 taacaaagcc aatgtcaaat aagccattat ttatgaaagg attttaaaca tgtctattat
    16801 ttctatggtt ttagtaatcg ttgtagcctt ctttgcaggt cttgaaggca tcctcgacca
    16861 gttccaattt caccaaccac ttgtagcctg tacccttatt gggcttgtaa caggtcactt
    16921 ggaagcaggg attatcctcg gtggatcgct tcaaatgatt gcccttggtt ggtcaaatat
    16981 cggtgctgct atcgctcctg atgctgcact tgcttctgtc gctgctgcca ttatcatggt
    17041 tcttggtggt gactttacca agactggtat cggtgttgcc caagcggttg ctatccctct
    17101 tgccgtagct ggacttttct tgacaatgat tgttcgtaca atttcagttg gtttggttca
    17161 tactgcagat gctgccgcta aaaaaggtga cttcggcgct gtggagcgtg cgcatttcat
    17221 tgcgctactt ttccaaggac ttcgtatcgc gcttcctgca gctcttctcc ttatggtacc
    17281 aactgaaact gtacaaagta tccttagtgc catgccagac tggctcaaag atggtatggc
    17341 tatcggtggt ggtatggtcg ttgccgttgg ttacgccatg gttatcaaca tgatggcaac
    17401 tcgtgaagta tggccattct tcgctcttgg tttcgttctc gctgctgtgt cagatattac
    17461 tctaatcgga ttcggtgcta tcggtgttgc tatcgctctt atctaccttc acctttctaa
    17521 aactggtgga aatggtggcg gaggagccgc aacttctaac gacccaatcg gcgatatcct
    17581 agaagactac taagataaga aaggactgaa aacatcatga ctgaaaaact tcaattaact
    17641 aaatcagatc gtaaaaaagt ttggtggcgt tcaaccttct tacaagggtc ttggaacttt
    17701 gaacggatgc aaaacttggg ctgggcttat acactcattc cagctatcaa aaaactctat
    17761 actaaaaaag aagatcaaat cgctgctctt gagcgtcacc ttgagttctt caacactcat
    17821 ccatacgtag ctgctccagt catgggggtt actcttgcgc ttgaagaaga acgtgctaac
    17881 ggtgtggaaa tcgatgacgc tgctatccaa ggggttaaaa tcggtatgat gggacctctt
    17941 gctggtatcg gtgacccagt attctggttt acagtacgcc caatccttgg atctctcggt
    18001 gcttcacttg cccttactgg caatatcttg gggccactcc tcttctttgt tgcatggaac
    18061 ttgattcgta tgtcattctt gtggtatgtt caagagattg gatacaaggc tggatcagaa
    18121 atcactaaag atatgtctgg tggtatcctt caagatatca ctaaaggagc ttctatcctt
    18181 gggatgttca ttcttgctgt ccttgttcaa cgctgggtaa atattaaatt tgctttcgat
    18241 gtttctaaag ttcaactaga tgaaaaggct tatatccatt gggataaatt gccagaaggg
    18301 tctaaaggta tccaagaagc attcgcacaa gtaggacaag gattgtctca aactcctgaa
    18361 aaagttacta ctttccaaca aaacttggat atgttgattc ctggattatc aggactactc
    18421 cttactttac tttgcatgta cttacttaag aaaaaagtat ctccaatcac tattatcctt
    18481 gccctcttcg cagtgggtat tgtggcacat gttcttcaca tcatgtaatc aagcaactaa
    18541 aaaggaacca ggttctaaaa tctgattcct tttttctatg cttttattta gccaaggctc
    18601 ccattggatc ccatggtgca agtacaattg gttctgctcc ataggcagct tgttcttctg
    18661 ctgtcagcaa ttccttacga acaacgattt ggtatgtgta ttcgtccatc caagcgtctg
    18721 aggcaacaaa gtaaccatct gtaccgacct tgtctcccca tgagttttca accttccact
    18781 tggttgattt accattttcg tccaagtcaa cacctgtcaa gaccatggcg tgggtcatca
    18841 agctttcgct atagtccaaa cgtccagcct tgtcttgagt aagtttaatg tccatgcttg
    18901 attcaaagtc ataaacatct gtcgcaagga ttccagcctt acggttactg agctggccga
    18961 catcagaacc aaaccaaaca gtctcacctg cttgcatttg ggcaatcgcc aattctttca
    19021 agcgctccat tggaacgttg atgtaacgaa ctgcacggct accaaccaca ttccccaaca
    19081 tctcaactgt gtaagatttt ccgtaaggtt tatcagcagt tggagcattg ataacagaaa
    19141 cgtagtcttc taaaggaaga ttgacatatt tcttgtagaa ctcttgtggt gtgattcctt
    19201 tttcactttt gtagttgtta tctttatcgc gataagcaaa gtcaaacttg cgtggtggaa
    19261 gtcctaatga catagcaaga aagttaaaga tttcttgcaa gaggtcttct ttcttagctt
    19321 gaacagtcac ttgatctgca ccagaaacaa gcaaatcacg caagatttga gcatcttgac
    19381 gaagcaattt attaaggatc gcatttagat cacgactgct gctagatgaa acagactcag
    19441 gataaactga cttaggcacg acaccgtatt tttcaaagag ggaaacgacc atatcccatt
    19501 gaccaccatc ttgttgaggt gtttggagta agaagctaac cttgcggcta gtcaattctt
    19561 ggtctgaagt cgcaatgact tgctccaaga accagtttga tttctcatac ttatcccaga
    19621 agaaagtgtg ggcttgtgac aactcaaagt tctccaattt gtattgcgag atgagtttgt
    19681 ggcggaaggt gttgagagcc gcaaacatcc agcaacgacc agacgctttc tggttagtga
    19741 ccttgtcctt ggttaaatcc aatgagaaaa caggtgtgtt gtctacatgg ctttggcgac
    19801 gttccagagc tgcaaaaatt ccgttgtggc tggcagcatt ttcaatcgct tggtatttta
    19861 catttgcttc atagttggca aatagtttat cagtaaatga ttcttgaatc gcgttcatag
    19921 attcctcctt ttattctaca gtctattata actcttttca caaaggaagc aactaaaaaa
    19981 cataaaaggt aaggacattc tccctcacct ttttcgaatt tatactcttc gaaaatctct
    20041 tcaaaccacg tcaacgtcgc cttgccgtac tcaagtacag cctgcggcta gtttcctagt
    20101 ttgctctttg attttcattg agtattaaac taaattaaat aatattagcg cggagaattt
    20161 ctaattcttc cttggtcaag cgacgccatt cccctcgttc caggttctca tctaatacta
    20221 aagttcccat agtcaatcgt tgcaagtcca ccacttcctt gccacagtag cccaccatac
    20281 gcttgatctg atgaaacttc ccttctgcaa tggtcacacg gatttggctc tgattctttt
    20341 ctgtatctat ggatacaagc tccagtatag cgggttgaca ggtaaagtct ttgagaggaa
    20401 taccctcagc aaatgtctcc acatcttctt gggtcatgat tcccttgact tgtgccagat
    20461 aagtcttatc cacatgacgc ttgggcgaaa gaagaacatg agccagctga ccatcattgg
    20521 tcaagagcaa aagaccatgc gtgtcaatat ccaagcgtcc tactgggaaa acttccttac
    20581 tccgcgccaa gtcatccaac aagtccagaa cggttctgtg cttgggatcc tcagtcgctg
    20641 agataactcc tttgggcttg ttcatcatgt agtagacaaa ctcttcatac tccaacactt
    20701 gcccatcaaa gcgaatctca tctatttttt catcaatctg caatttagct gatttttctt
    20761 ttttaccatt tacagtcacg cgcccagcct tgagcaagtt tttgacctca gtccgacttc
    20821 ccaccgcaca ggcaactaaa aatttatcta atctcataga actattatat catatcaaaa
    20881 ggaggctggt acaatgacca acctcctttt cgtttcatac tcttcaaaaa tctcttcaaa
    20941 ccgcgtcaac gtcgccttgc cgtatatatg ttactgactt cgtcagttct atctgcaacc
    21001 tcaaagcagt gctttgagca acctgcggct agtttcctag tttgctcttt gattttcatt
    21061 gagtatcaga tttaggaaat taacttcctc gtctccaaaa aatagctaaa acaatcatgg
    21121 ctcctaaaat cgctgggata atagctgttc ctgataaaac tggcccccaa gttccaaaga
    21181 gcaagtgacc tagaaaggct ccgatccaac cgagaaacat ttttccaaaa catcccattc
    21241 gctctccacg attggtcata gcacctgcta aaaatcccac taggagacca acgaacatac
    21301 ttcctaacat attatctcct taatttgccc aattcccatt acggaaaaga ggtacccgcg
    21361 ttccatcctc acgaatacca tcgatatcca tttggttaga accaatcata aagtctacgt
    21421 gaacatctga acggttaagc cctgcagctt caagctcctc ttcgctcatc tccgctccat
    21481 caacaacgct agtcgcatag gctgcaccga tagccaagtg gtttgacgca ttttcatcga
    21541 aaagggtgtt aaagaagata atgcctgact gagaaattgg acttggatct ggtaccaagg
    21601 cacattcacc caaggcacgc gcacccgcat tttcaaagac aaggtctttc ataacctgat
    21661 cacccttctc agcagtgata tctacgattt gtccatcctt aaaggtcacc ttaatgcctt
    21721 caatgatatt tccgttgtag ctaagcggtt ttgtagaagt gacataacca tctgcacgac
    21781 ggaagtcagg cgctgtgaag acctcttctg tcggcatatt tggcaagaat tcttcgccct
    21841 gtgcattgac agcaccagct gattcccaaa cgtggttctt tggcaaacca agtgttaaat
    21901 ctgttcctgg cgctgtgtag tgaagggctg aaaattgctc cttattaagc atatcggcct
    21961 tgctcttgag aatggctgca tgttcctccc aagccttaac aggatctgct tcgtagacac
    22021 gacaagtttt gaagatttga tcccaaagga aatcaactgc ttcttcgtcg ctcgcagcat
    22081 ttgggaagac tttcttagcc cactcaagtc cagcagcggc tgctacagtc cagctaacct
    22141 tgttagattg agttgcgatt cgcattggct tcatggcaag tcccatagct ttagcagaag
    22201 ctgaaagctt gtcagcgtcc actccgttca aggcacctgg atcagatgaa cgaaccccaa
    22261 gacggctagc cttgttctcc aaaagatagt tcatctcagc aatcttgtat tctggcacat
    22321 tgtccaaacg ctccatcggg gcatggagga atttctcacg gttaatcaca tcatctgtcc
    22381 actgaacgat gacctcatgc gcacccaagg cataagcttc tttcacgatt agatgtgcca
    22441 attcacgttg ctccacatca atagagagag ccaaagtgtg accaggttgc acgttaattc
    22501 cgttcgcaac caacaatttc gcatattttt ctagattttc tttaaaattt ggtaaaacca
    22561 ttctgttttc tcttttctat ttttattttt ctttcaaagc agaaaagatt cctgctaaag
    22621 caatagcacc tggcaagagt gctgtcgata gaagaattgt acgatcagca agttctaatt
    22681 gatattcaaa taccttctta gccggcttat cttccgcaaa tattcttagt ttcatgagaa
    22741 cccccttaaa atagattaaa ataaatcact gtgactgcct gtcctcagca aatttaaaat
    22801 caattccgac ttgtctactt tataaaccaa aagccaatct ggctgggtat ggcattcacg
    22861 aactccttga aaatgcttgg atgccgtcaa tgaatgatca cgatatctgg caggatgttc
    22921 tttttcttga accagaaaat tcaaaacttc ttctaataat tctgccctca aaccacgctt
    22981 catagccaac ttaaaatctt ttttaaactg tttatgataa cgaatcttaa gcacgtaagt
    23041 cctccatcaa atctgagact gattcaaaag actggctcat attacgattt tggtctaaat
    23101 ccgttaacgc ttggagcaac ttccgatttt cgtctagtct aacatcaaaa ggtaatccct
    23161 gatattgaat tgcctgacga aggaaaatat taatagctgt tgtcatatcc attcccagat
    23221 tactaaacac ctgttgggcc tgctccttaa cctcactatc cagacggatg cttatactca
    23281 tctttgacat actctcaccc tctttccata gactatttta acaaaaaaga aagctaatgt
    23341 aaatctattg gatatacgtt agcctctttt aatagattat taagcaattt tttaaaacaa
    23401 ctcatcaaac aaactcaact ggttatcctc tggcatattt ccaagaatac ccatctcatc
    23461 catcttttca accaaggttg atgagagtcc accacgcttg cgtagttctg ttttagagag
    23521 gaattctccc tcttcacgcg cccgcaccag ttgcttggca acgttctctc ccagaccatc
    23581 cattgctaca aatggtggga taagggtatc cccgtcgatg aggaactctg tcgcctgact
    23641 acggtagaga tctaatttac caaacttgaa acctcgttcc cacatctcat tgacaatctc
    23701 aagagttgta tagagatcga tttccacatt agaggcttca ttgttcttcc gtttttcaga
    23761 gatttcttcc attctgcgct tgatgacctc caagcccgca cccatggtct tgatatcaaa
    23821 agccttagca cgaatggaga agtaagcaca gtagtaataa ataggatggt gaaccttgaa
    23881 gtaagctaca cgcaaggcca tcataacgta ggctgccgca tgggccttag ggaacatgta
    23941 cttaattttc ccacaggatt cgatatacca ctctggcacc ttattagcct tcatggcttc
    24001 gatatagcca tttctctcct cttctgaaat ctttagccac aaacccttac gtacccgttc
    24061 cataatggta aaagccatct taggttccag acccgcatgc atgaggtaaa ccatgatgtc
    24121 gtcccgacaa ccgataacag tcgataggtc cgctattcct tgcttaatca gatcctgagc
    24181 attccccaac caaacgtcag taccgtggga cagaccagac agctgaagca attccgcaaa
    24241 ggttgtcgga tgggtttcgt ctaccattcc acgtacgaaa tttgttccaa actctggaat
    24301 ccccaacata cccgtaggcg ttccaatttg ttcaggtgtt acccctagta catcagtccc
    24361 agaaaagagt gccatcacgc cttcgtcatc cataggaatt ttattagggt caataccaga
    24421 caaatcctga agttttcgaa tcatggtcgg atcatcatgt cccagtacat cgagtttgag
    24481 gacgttctca tcgatatcgt ggaagttaaa gtgagtggtc tgccattcag ccgtgacatc
    24541 atctgctgga tactggacag gcgtaaaatc gtagacatcc atgtagttcg gaataacaac
    24601 gattcccccc gggtgttggc ctgttgtccg cttgacaccc gccgctcctt gagcgaggcg
    24661 ttctacttct gcatcacgat aaaacttgcc ataatctcgc tcgtaaccct tgacaaatcc
    24721 ataggcagtc ttggcagcta ccgtaccaac cgttcccgca cggaaggcat attcttcacc
    24781 aaagatatca cgcacatcca agtgggcgct aggctgatct tctcccgaga agttcaagtc
    24841 aatatcagga accttatccc catcaaaacc aaggaaggtc tcaaacggaa tatcctgtcc
    24901 gtttttactg agtttgtgac cacagtttgg acagtcctta tggggcatat caaatcctga
    24961 accgtacgaa ccatctgtga taaactcact gtactgacac tgaccacaga catagtgagg
    25021 agagagagga ttgacctccg taatcccaat catggtcgca acgaaactag atccgacaga
    25081 cccacgagaa ccaaccaaat aaccccgttc attagaacgt tgcaccagca tctgcgatgc
    25141 cagataaatc acagcaaatc cattccccag tatggatgtt aattcttttt caatccgcaa
    25201 atcaacaata tctggcagcg gatttccata aatctcaaaa gctttcttat aggtcaactc
    25261 agcaactgtt tcttcagcct tgtcgatgaa aggcgtatac aagtcaccct taacgacttc
    25321 aacgggttca aatatttctg ccaaggcatt ggtgttttca ataaccagtt tacgagccag
    25381 ttcctctccc aaaaaggcaa attcatccaa catctcatta gtcgttcgaa aatgagcctt
    25441 tggaagtggc gctggttggg catgttcacc atgaccgata gttcggttaa tcatcgcacc
    25501 ctgtcccaaa ctacggacga taatttcacg ataaatctct tcttccggtt cgatatagtg
    25561 aacatttccc gtagccagaa caggcttgcc aaggcgatct ccaacctcta tcaaactctt
    25621 gataatggtc tggagttcct ccatatcctt gacctgctct ttggcaatca agggcgcata
    25681 gatagccggt ggcatgacct cgataaagtc ataatacttg gccacctcaa ccgccgcatc
    25741 cacaccttga gaaacgacca cgtcaaaaac ttcaccctct gaacaggctg aacctaaaat
    25801 caagccctct cgatgggcat ctagaaccgt tctcggaatc cgtggcactc cttcaaaata
    25861 cttggtatta gacaaggaaa ccagcttaaa gatatttttt agacctacct gattcttgac
    25921 atagatggtc gcatgcttga tccgagcttt tttgtaagaa tctggactga ttagatcaat
    25981 gttgagtcta gctaaatcgg tcacaccatg tttttctgct acctctttga taaagatgaa
    26041 aagcagacga ccagtcgctt ccgcatcgta gttggccatg tggtgatgtt ccaaggccac
    26101 accaaaacgc ttggtcaaag gccccaaacc atggcgttta tactcaggat agaggtttct
    26161 agcaaactcc agcgtatcaa taactggctg actaatcttt ggaagatcat gacgctcata
    26221 attagcattc ataaagccaa cgtcaaaggt agcattgtgg gcaactagga ccgtatcctt
    26281 gcaaaattct tggaattctt gcaaaacttg ttctagtggt ttggcatttt tgacatgatc
    26341 atctgtaatt ccagttaact ctgtagtaaa agctgacaag ggatgcccag gattgataaa
    26401 ttcatcaaat tcagcaataa cattcccctt gtacatctta gaggccgcaa cctgaatcaa
    26461 gtcattatag atagctgaaa gtcccgtcgt ttccacgtca aagaccacgt aggttgcttc
    26521 tgataagtcc atctccactt cgttatagac gatagggaca cggtcctcca cgatattggc
    26581 ttccatccca tagatcagct ggattcccgc tttcttagcc gccttatagc catgtggaaa
    26641 ggactggaca ttcccatggt ctgtgatagc aaccgccttg tgtccccact tagcagctgt
    26701 tgcaacaatc tcttcgacct ctggcaaagc atccatagtc gacatgttag tatgagcatg
    26761 aaactcaacc cgacgctcac cttctggcat caaatccttc cgctcatagt gaacaacttc
    26821 ctgcagatcc tgtacgttca tagtcaaatc gcgtgtgaag ttattcatct ccacattccc
    26881 tcgaactcgg agccaagaat tcttcttgat gaggtcaaac ttctgggcct cttcctcgtt
    26941 tttaacccac ttttgcatag aaaaacttga agtatagtcc gtcattttaa agttgattaa
    27001 aacacgacct gttctagtca ctttttgctc cacatcaaaa acaacccctt caaataccag
    27061 acgattttcc tctgtcgtca cttcgatcat aggagtaatc tccgccttat ccagcttggg
    27121 tttagctgca gcttttttcg cttgaaaatc aaagactggt ttctcttccg ctggaggagg
    27181 tgccatctgc tccagttgtt ccatagcacg gagcgcttcc tcattggcag cttgaacaat
    27241 ctgctcattt tcagcatgaa aggcctcttc ctgctcttgg gtcaggacat cattcttctc
    27301 gacttgacag ttaaaagttg gaaaaccaaa cttttcaagt tgtttagcta aattaggaag
    27361 atgattcttc ttaaaatgtt ccttatcaat cgcttcagat ccttcaataa atagctgatt
    27421 accctcagca cgaacttgca aattttgata aaggaactta aaaccttgac tagcacatgg
    27481 accttcagag aaagcctccc tatagtagga ctgcaagagc tgatttgaaa attcttgaga
    27541 ccgagcctta atttcaaaaa cagctttatt gcctgtctta gaaaattctt cgctcaaacc
    27601 tttctttaat tctaaaaaga tttcaatcgg taaaatatta gaaaatacaa aatgaaactc
    27661 ccatacctta ctaattttat gaaccacaac tcgctcaata ttggcctgtg ctaaagcagg
    27721 agcctgtctc atttcagcag gcatccccaa ttgattcatc aaaatttcaa aactatttga
    27781 cattcatttt cctcacatta ttcttctact attttaccat atttagaggt attttctaaa
    27841 gacaaaagga agccactaag tgacttcctt ctagagtgag gacggattag tcttcacctt
    27901 tatttttctt aataatttct tcttgtactg acttaggtac atcttcgtag tggtcaaata
    27961 ccatcatgaa tgtaccacgt ccttgagatg cagaacgaag aactgttgcg taaccgaaca
    28021 tttcagcaag tggaacgtaa gcacgaacga tttggctgtt accgtgtgct tccataccat
    28081 ctacacgtcc acgacgagca gttacgtgac ccataacatc accaaggttt tcttctggaa
    28141 cagtgattgt tacaagcatc attggttcaa ggatagctgg ttgtgctgat ttagcagctt
    28201 ctttaaggga aagtgaagcc gcaatcttga aggcagtttc agatgagtcg acatcgtgat
    28261 atgaaccatc ataaagctta gctttaacgt caaccattgg gtaacctgca agaacaccgt
    28321 tagccataga ttctaccaaa cctttttcaa ccgctgggat aaattcacga ggaaccacac
    28381 caccgacgat tgcgttttcg aattcgaatc ctttaccttc ttcgtttgga gtaaattcaa
    28441 tccacacatc accgaattga cctttaccac cagactgacg tttgaagaat ccacgtgctt
    28501 gggtagaagc gcggaatgtt tcacggtaag atacttgagg agcacctacg ttcgcttcaa
    28561 ctttgaactc acgacgcata cgatcaacaa ggacgtcaag gtgaagttca cccatacctg
    28621 agataactgt ttcaccagtt tcaacgtttg tttcaacgcg gaatgttgga tcttcttcag
    28681 ccaatttttg aagggcgata cccatcttgt cttggtcagc tttagatttt ggctcaacca
    28741 tcaattggat aactggttct ggaacgttga ttgactcaag gatgatttta gatttttcat
    28801 ctgtcaatga gtcaccagtt gtagtatctt tcaaaccaac ggcagcagcg atatcacctg
    28861 agtaaacagt gtcgatttct tgacggctgt tagcgtgcat ttgaaggata cgtccgatac
    28921 gttcacgttt acctttagaa gtattcaata cgtatgaacc tgattgaaga acacctgagt
    28981 aaacacggaa gaatgtcaaa cgacctacga atgggtcagt catgatcttg aaggcaagag
    29041 ctgcaaatgg ctcttcgtca gatgctggac gagtttcttc agcgtctgta tctgggttaa
    29101 tacctttgat tgctgggatg tcaagtgggc ttggaaggta gtcgataacc gcatcaagca
    29161 tcaattgaac acctttgttt ttgaaggctg aaccacacaa tactggaaag aattcaacgt
    29221 tgatagtcgc tttacggata ccagctttca attcttcgtt agtgatttct tcaccttcga
    29281 ggtatttcat catcaattct tcgtcagttt cagcaactgc ttcaatcaat ttttcacggt
    29341 attcttgagc ttggtcaagg tattcagctg ggatgtcttc ttcaaggata tccgtaccaa
    29401 ggtcgttagt atagatttca gctttcatct tgatcaagtc aatgatacca cggaagtcat
    29461 cttcagaacc gattggcaat tggattgggt gtgcatttgc ttgaagacga tcgtgaagtg
    29521 tgcttacaga gtaaaggaag tcagcaccga ttttgtccat tttgttggca aatacgatac
    29581 gtggaactcc gtactcagtt gcttgacgcc aaactgtttc agtttgaggt tcaacacctg
    29641 attgtgagtc aagaacggta accgcaccat ccaatacacg aagagaacgt tgtacttcga
    29701 ttgtgaagtc cacgtgtcct ggtgtgtcga tgatgtttac gcggtggttg ttccattgag
    29761 ctgttgtcgc agcagatgtg atcgtgatac cacgttcttg ctcttgctcc atccagtcca
    29821 tttgtgacgc accttcgtga gtttcaccga ttttgtggat tttaccagtg tagtaaagaa
    29881 tacgctcagt agttgttgtt ttaccggcat cgacgtgagc catgataccg atattacgag
    29941 ttttttcaag tgaaaattcg cgtgccatga ggtttgtttc tcctatttat ttttgatttc
    30001 tattctatta taacacgatt ttaataaaaa cggataggca ggacctaccc gttctcaatg
    30061 ttttcatgct attgttggtt tcaacttact agatggtaag ctgagttata gctaatacta
    30121 atcgatttag ctaatttgaa cccgggctaa agttagttag ccgatgtgag ctggaacggg
    30181 atgctgcgtg aaaaagataa aactccttgt attcgttgaa tactgcgtca gtttcctatt
    30241 ttcaccttgc atccttaccg tgcctagcat catgatttag ttgagctcaa gctaaaagtc
    30301 tggagaaaaa gatgaatctc attggttgca accgcaacct gcttcgattc cctattttct
    30361 ctgggacttt cttaacgctt tcgcatccta tcttaccaac ggaagtgtgc gaatgcacgg
    30421 ttagcttcag ccatacggtg agtatcttca cgtttcttaa cagctgcacc agtgttgtta
    30481 acagcatcca agatttcttt tgcaagacgg tcttgcattg tgtgttcacc acgaagacga
    30541 gcgattgtta ccaaccaacg aagtccaagt gttgtacgac gttctggacg aacttcaact
    30601 gggacttggt agttagaacc accaacacga cgtgcacgta cttcaagtac aggcatgatg
    30661 ttttccatag ctgtttcaaa tacttcaagt gcatcgttgc cagtagcttc tttgatttgc
    30721 tcaaaagcac cgtaaacgat tgaagcagca gtaccacgtt taccatcaag cataacgcgg
    30781 ttgataagac gagtaactag ttgtgaattg tatagcggat ctggcaatac gtcacgtttt
    30841 ggagctctat ttttacgact catttctctt tatccccttt ccttatgctt ttggacgttt
    30901 agtaccgtat ttagaacggc cttgtttacg atcgttaaca cctgcagtat caagtgcacc
    30961 acggacgata tggtaacgta cccctggaag gtcttttaca cgtccaccgc gaagaagcac
    31021 cacgctgtgc tcttgcaagt tgtgtccgat acctgggatg taggcagtaa cttcgataag
    31081 gttgctcaaa cgtacacgag cgaatttacg aagggctgag ttaggttttt taggtgtcat
    31141 tgttccaaca cgagttgcaa caccacgttt ttgtggtgaa gaaacgtttg tttgaacttt
    31201 tttatgacta ttgtaaccaa cgttcaaagc tggtgattta gatttttcta cttttgattt
    31261 acgcggtttg cgaaccaatt ggttaattgt aggcatctac attctcctgt gtttttttat
    31321 ttttggtgat gatacacttg gtgacagata tcatctgtgt gtacttttgc aacatttgtc
    31381 agcacgtccc tgtacactct tgagagacca aaagtaaaaa gtaccgtcta tcattgtaac
    31441 aaaattttcc cttgcttgtc aagatatttt tcatttttat tggtaatgtt agagatcaat
    31501 ttctgaataa aaatagctgg gaacacatca tcttcctaat aatacggctt ggcttatgtg
    31561 acatttttat ctccgtcatt tatactgata tataaaatag tacagaaaac ttctcaaaag
    31621 taagaatttt tttcacaaat caaagaaaac gcttgcatat tattttacta catgctatac
    31681 tgatatagaa atttattgat tggagaatca ttatgagaaa aacaccatct cacactgaga
    31741 aaaaaatggt ctacagcatc cgttccctca aaaatggaac tggttctgtc cttatcggcg
    31801 caagccttgt cttgcttgcc atggctacac caactatctc atccgacgaa agtacaccaa
    31861 ccactaacga acccaacaac agaaatacaa ccacccttgc ccaacctctt actgatacag
    31921 cagctggctc tggtaagaac gaaagtgata tttcttcacc tagaaatgca aacgcttccc
    31981 tagagaaaac agaagaaaaa cctgcaacag agccaactac ttctactagt ccagtaacaa
    32041 ctgaaactaa ggcagaagag cccatcgaag ataactactt ccgtatccat gtcaaaaaac
    32101 ttcctgaaga aaacaaggat gctcaaggac tatggacttg ggacgatgtt gaaaaaccat
    32161 ctgaaaactg gccaaacgga gctttgtcct tcaaggatgc caagaaagat gactacggct
    32221 attacctaga tgtcaaatta aagggagaac aagccaagaa aattagcttc ctcatcaaca
    32281 atacagctgg aaaaaatcta accggcgata aatctgtaga aaaactagtt ccaaaaatga
    32341 acgaggcttg gttagaccaa gattacaagg ttttctctta cgagccacag cctgcaggaa
    32401 ctgttcgcgt caactactac cgcacagatg gcaactatga caagaaatct ctctggtact
    32461 ggggagatgt aaaaaatcca agtagcgctc aatggcctga cggaacagac tttacggcta
    32521 caggcaaata tggccgctat atcgacattc ctcttaatga agccgcaaga gaatttggat
    32581 ttttattact agatgagagc aaacaaggag acgacgtgaa aatccgtaaa gaaaattata
    32641 agttcacaga tttgaaaaat catagccaaa ttttcctaaa agacgatgat gaatcgattt
    32701 acacaaatcc atactatgtc catgatatcc gtatgacagg agcccaacac gtaggcactt
    32761 ctagcattga aagtagcttt tcaacacttg tcggtgctaa aaaagaagat atcctcaaac
    32821 actccaacat cactaatcac ctaggaaaca aggtaactat taccgatgtt gcaatcgatg
    32881 aagctggtaa gaaagtgacc tacagcggag atttctctga cacaaaacat ccttatactg
    32941 ttagctacaa ttccgaccaa ttcactacca aaacaagctg gcgcctgaaa gatgagacat
    33001 acagctatga tggcaaactg ggagctgacc taaaagaaga aggaaaacaa gttgatttga
    33061 ccctttggtc accaagtgct gataaggttt ctgttgttgt ctacgacaag aatgaccctg
    33121 acaaagtagt tggaactgtc gctcttgaaa aaggggaaag aggaacttgg aaacaaactc
    33181 tagacagcac aaacaaactc ggaatcacag atttcactgg atactattat caataccaaa
    33241 tcgagcgtca aggtaaaact gttcttgcac tcgatcctta cgctaaatct cttgctgctt
    33301 ggaatagcga cgatgccaag attgacgatg cccataaagt ggctaaagcc gcctttgtag
    33361 atccagctaa actcggacct caagacttga cttatggtaa gattcacaat ttcaagactc
    33421 gtgaagacgc cgttatctac gaagctcatg tgcgtgactt cacttcagat cctgccattg
    33481 caaaagactt gaccaaacca tttgggactt ttgaagcctt cattgaaaaa ctagactatc
    33541 tcaaagactt gggtgtaacc catatccagc tccttccagt cttgtcttac tactttgtca
    33601 atgaattgaa aaaccatgaa cgcttgtctg actacgcttc aagcaacagc aactacaact
    33661 ggggatatga ccctcaaaac tacttctcct tgactggtat gtactcaagc gatcctaaga
    33721 atccagaaaa acgaatcgca gaatttaaaa acctcatcaa cgaaatccac aaacgtggta
    33781 tgggagctat cctagatgtc gtttataacc acacagccaa agtcgatatc tttgaagacc
    33841 tagagccaaa ctactaccac tttatggatg cagatggcac acctcgaact agctttggtg
    33901 gtggacgctt ggggacaacc caccatatga ccaaacggct cctagttgac tctatcaaat
    33961 acctagttga tacctacaaa gtggatggct tccgcttcga tatgatggga gaccatgacg
    34021 ccgcttctat cgaagaagct tacaaggctg cacgcgccct caatccaaac ctcatcatgc
    34081 ttggtgaagg ttggagaacc tatgccggtg atgaaaacat gcctactaaa gctgctgacc
    34141 aagattggat gaaacatacc gatactgtcg ctgtcttttc agatgacatc cgtaacaacc
    34201 tcaaatctgg ttatccaaac gaaggtcaac ctgcctttat cacaggtggc aagcgtgatg
    34261 tcaacaccat ctttaaaaat ctcattgctc aaccaactaa ctttgaagct gacagccctg
    34321 gagatgtcat ccaatacata gcagcccatg ataacttgac cctctttgac atcattgccc
    34381 agtctatcaa aaaagaccca agcaaggctg agaactatgc tgaaatccac cgtcgtttac
    34441 gacttggaaa tctcatggtc ttgacagctc aaggaactcc atttatccac tccggtcagg
    34501 aatatggacg tactaaacaa ttccgtgacc cagcctacaa gactccagta gcagaggata
    34561 aggttccaaa caaatctcac ttgttgcgtg ataaggacgg caacccattt gactatcctt
    34621 acttcatcca tgattcttac gattctagcg atgcagtcaa caagtttgac tggactaagg
    34681 ctacagatgg taaagcttat cctgaaaatg tcaagagccg tgactatatg aaaggtttga
    34741 ttgcccttcg tcaatctaca gatgccttcc gacttaagag tcttcaagat atcaaagacc
    34801 gtgtccacct catcactgtc ccaggccaaa atggtgtgga aaaagaggat gtagtgattg
    34861 gctaccaaat cactgctcca aacggcgata tctacgcagt ctttgtcaat gcggatgaaa
    34921 aagctcgcga atttaatttg ggaactgcct ttgcacatct aagaaatgcg gaagttttgg
    34981 cagatgaaaa ccaagcagga tcagtcgaaa ttgccaaccc gaaaggactt gaatggactg
    35041 aaaaaggctt gaaattgaat gcccttacag ctactgttct tcgagtctct caaaatggaa
    35101 ctagccatga gtcaactgca gaagagaaac cagactcaat cccttccaag cctgaacatc
    35161 aaaatgaagc ttctcaccct gcatatcaag acccagctcc agaagctaga cctgattcta
    35221 ctaaaccaga tgccaaagta gctgatgcgg aaaataaacc tagccaagct acagctgatt
    35281 cacaagctga acaaccagca caagaagcac aagcatcatc tgtaaaagaa gcggttcaaa
    35341 acgaatcggt agaaaactct agcaagaaaa atatacctgc aaccccagat agacaagctg
    35401 aacttccaaa tacaggaatc aaaaacgaaa acaaactcct atttgcagga atcagcctcc
    35461 ttgcgctcct tggtctcggt ttcttactaa aaaataaaaa agagaactaa actagccctc
    35521 ctatagaaaa atcccccaag cattatagct cgggggatta attttcgtac aatatttgtt
    35581 gtcctaataa acttgattag gattttttat taagcctctt tcatagcaaa ataagctcgt
    35641 actttgggtg caacttgtgt tccgaagagt tcaatagctc tcagaacctg gtcatgaggc
    35701 atagaaccaa gcggtagatg aagcatgaag cagtccaatc ctaaatcctc tatcatgcga
    35761 atcaattttt cggccacctg atctggattg ccaacaaaca tggcgccatt tgaccctacc
    35821 tgatccaaat attgctcata acgcaattcc tgccagtgcg gacggtcttt ggaaatagca
    35881 tccaccactt gcttagtcgg atggaaataa tctttcaccg cctgctcacc atcttccgca
    35941 atccaccccc aagaatgggc tcccactttc aagtctttgt cagcatggcc cgcttcgctt
    36001 ccaatctcac gataagcctg aatcaacttt ttaaaataac gtggattacc atcaataata
    36061 gcatatacaa tcggtagacc agcctgagca atcttcactg ttgattcgac atgaccacct
    36121 gtagctatcc acaagggcaa tttgtcctga actggacgag gataaacttc tttaccagca
    36181 atcgtttgag tcaatcgacc ttgccagtct aacttggtct tttcattgac taactgaagc
    36241 aagtctaatt tctcatcaaa aagagagtcg tagtctttca agtcataacc aaacagaggg
    36301 aaagattccg tgaaagagcc ccttccagcc ataatctccg ctcgtccatt tgacaaagca
    36361 tcgatagtgg catactgttg gaacaaacga atcgggtcca tgcttgacag aatgctgact
    36421 gcgctggtca aacggatttt cttggtattg actgccccag cggccaggac aatctctggg
    36481 gctgatactg caaaatccgc ccgatggtgc tcgccaatcc catatacgtc caaaccaacc
    36541 ttgtcagcca gctcaatctc tgccaccaac tggcgaatgc gttcagcatg actgtaagtt
    36601 tgtccagtcc cttcaagctc cgttatttcc ccaaatgttg aaattcccaa ttctaccatt
    36661 gtgattctcc ttgtctatct ctgtccttca atttgaaaaa ttattctaac acgaatctta
    36721 agtacaagca accaatttgc tcattagaaa aagcctagat aactagactt ttttagctta
    36781 ttctaccgtt actgatttag caaggttacg tggtttatcc acatcgaggc cacggtggag
    36841 ggttgcaaag taagcgacta attgcgttgg tacgaccatt gaaattggtg agaggtatgg
    36901 atgtacggtc gtaaggacga tatcgtcggt atctttggct acattctctt ctgcgatagt
    36961 gaggactttg gcaccacggg ctgcgacctc ttggatattt ccacgagtat gattggcaag
    37021 aactggatct gacaagagag ccaaaacagg cgttccttct tcaatcaagg caatggttcc
    37081 gtgcttgagt tctcctgcag caaagccttc acactggata taagaaatct ctttgagttt
    37141 gagacttgct tccatggcta cgtagtaatc ttgaccacgt ccgatgtaaa aggcgttacg
    37201 agttgtttca agaagttcac gaaccttggc ttcaatggtt tctttctctg aaagagttga
    37261 ttcgatagac tgagctacga ttgacaattc atgaatcagg tcaaaggctt gcgctttagc
    37321 attaccattt gcttctccga ctgcttttgc aaggaaggca agggctgcga tttgcgctgt
    37381 ataggcttta gttgatgcca cggcaatttc aggacctgcg tgaaggagca tggtatagtt
    37441 ggcttcacgt gagagggttg agcctggaac atttgtcact gttaagcttg gaattcccat
    37501 ttcattagcc ttgaccaaaa cttgacgact atccgctgtt tcaccagatt ggctgataaa
    37561 gatgaagagt ggtttcttgc tgagaagtgg cataccgtag ccccactcag atgagatgcc
    37621 aagttcaact ggtgtatctg tcaattcttc caacattttc ttagaagcaa atcctgcatg
    37681 gtaagatgtt ccagctgcaa ggatgtagat gcggtctgcg tcttgaacag ccttaatgat
    37741 agcaggatca accactactt gaccagcatc atccgtgtag gcttgaatga gtttacgcat
    37801 aacagttggt tgctcgtcaa tttccttgag catgtagtaa gggtaagttc ccttaccgat
    37861 atctgacaag tcaagttcag cagtgtagct agcacgctca cgacgatttc catcatagtc
    37921 ttgaacttcc acactatcag ccttgacgat taccaactct tggtcatgga tttccatgta
    37981 ttggttagtt tcacgaatca tagccatggc gtctgagcag accatgttat agccttctcc
    38041 aagaccaatc aaaagtggtg atttattttt agctacgtag atgacttcag gatcttgtga
    38101 gtcaaccaag gcaaaggcat aagaaccacg gatgatgtga agggcttttt tgaaggcttc
    38161 aagaactgag agcccttctt cttccgcaaa ttttccaatc aaatgaacgg ctatttcagt
    38221 atctgtctgc cccttgaagt ggtgacctgc aaggtattct tccttgattt caagatagtt
    38281 ctcaatcacc ccattatgca ccaagacaaa acgttctgtc tcagagcggt gtgggtgagc
    38341 attgtcctca gttggttttc cgtgagtagc ccaacgagta tgtccgatac cagttgttcc
    38401 ctcaacacca gctgtcttgg cagacaattc tgcaatacga ccaaccgcct tcaccaaatg
    38461 gttatcagca ccatctagga caaaaattcc cgcagaatca tagccacggt attcaagctt
    38521 ttcaagccct tgaatcaaaa tatcagttgc atttgtgttt ccaacaacac caacaattcc
    38581 acacatagta tatacgacac aggcaagctg tgctttctcc ttaaaattgg tatagtctaa
    38641 ttcatctttt atagaatcag caaaaacagt atatacttgt ttctttcact tgtcaagagt
    38701 aaaaattggt atagttcaaa ttaagctcct gtaagcaaaa aactctgacc gattgggata
    38761 atcagtcaga gtccttttta aaatccatta ttgtcgctta gtttcttgaa ccagtggcct
    38821 gatttcttca gacgacgttc ttgcgtttcc aagtctaatt cgaccaaacc atagcgattt
    38881 ttatagctgt tgagccatga ccagcagtca ataaaggtcc aaatcaagta gcccttacag
    38941 ttggcaccat cttcaatggc acggtgaagt tcacgaagat gaccttttac aaagtcaata
    39001 cggtaatcat cttgaatcat tccatcttga cggaattttt cttccccttc aacacccata
    39061 ccattctcag tcaacatcca ctcaatattg ccataatttt ccttgatatt ttgggcgatg
    39121 tcataaatcc cttgctcata aatctcccaa ccacgatgag aattgatttt acgtccaggc
    39181 atcacataag gctcgtaaaa atgttctggt aagagtggac tctctggatg cttagcaaat
    39241 cgaggagcca taacacgcaa aggttgatag tagttcacac caaggaagtc caccgtatta
    39301 tcacgaatga gttccaactc ttcctctgta gcatcaggta aaagaccgtg ttcatgcaag
    39361 atttctacca actcctgtgg ataagtcccc aagacagatg gatctaagaa agattgggcc
    39421 tgaaaaaggg ccgcaatacg agctgccttg acatcagcag gatgctggct acgtggataa
    39481 gccggtgtca agttgaggac aatcccaatc ttggaatcag gcaaaagttc atggcaagcc
    39541 ttaacagccc ggctgctggc caattgtgta tgataggcta ccttaacagc tgcctctgca
    39601 tccaccttat gtggataatg ggcatcataa aaataaccaa attctacagg aacgatgggc
    39661 tcgttaaagg taatccattg atccactaaa tctccataag tctcaaaaca aaaacgagca
    39721 tagtcttcat aggctgagac tgtcgcctta ttttcccaac catcaccatc ctcttgaagg
    39781 gcaaaaggta aatcaaaatg atagagattg actaacagac aaattccttt agccttaata
    39841 gcctcaaaga ccttacgata aaaatccaca ccttgagggt tgacttttcc acagccttgt
    39901 ggaaaaatcc gtgaccactg aatagaagtc cgaaagactg tgtgaccagt ctctaacaaa
    39961 agctcaatat cccgctccca attttcataa aaagtcgatg tcttatctga accaatccca
    40021 ttatagtaac gatttggctc cacttggaac cagtaatccc agagattgtc tcccttaccg
    40081 tcaccagcta cacgtccttc tgtctgcggt ccagaagtag aggatcccca gacaaaatcc
    40141 tttggaaatc ttagcataac atttacctct ttatctactc atttctccca ttatacagaa
    40201 aaaacaaggt aaaaactagt tacatttttt ccttgttttt cttctgatta tagtttttat
    40261 ttcttgctta ggatttcaag cgtttcaagc acgttatctg catgaacctc aatggtgtca
    40321 ccagttgcct tgatcttaac ttctacaatg ccatcggccg cttttttacc aacagtgata
    40381 cggattggaa gaccaatcaa gtcactatcg ctaaatttaa caccgacacg ttcgttacgg
    40441 tcatctgtca agacttcata accagctccc atcaagcttg cttcaagttt ttctgtcaag
    40501 gcttgcgctt cttcatcctt gacattgaca gtaatcaaat gcacatcaaa tggtgccaat
    40561 tctttaggga aattgattcc ccaagcgtaa cggtattcac cttttggcgt tttgttaaca
    40621 aagaggcgag cgtgttgctc catcactgct gaaagaagac ggctgacacc gataccgtaa
    40681 catcccatga tgattggcac agcacgacca ttttcatcca agacatctgc tcccatgctt
    40741 gctgagtagc gagttccgag tttgaaaata tgaccgatct caataccacg cgcaaagtta
    40801 aggacacctt gtccatctgg ggaaatttca ccctcacgaa cttcacggat atccacatat
    40861 tctgcagtaa aatcacggcc tgggttcaca ccagtcaagt ggtagccatc ttcgttagca
    40921 ccgacaactg cattgcgaac atcttgcacc ttacgatctg caataatttt aatattctct
    40981 ggcaaaccaa ctggtccaag tgaaccaaat cctgcttgaa caacattcgc cacttcttct
    41041 tcgctagcaa cgtcaaagaa atctgctccc aagtggtttt tcaacttgac ttcgttgagt
    41101 tggtcatttc caactagaag ggctgcaaca agctcaccat ctgcaatgta gaagagggtt
    41161 ttaatcgttt gttcttctgg aacattgagg aaagctgcaa cttcatcaat tgatttaaca
    41221 tctggcgttg caacacgagt aacttcttct tcagcgacaa cacggttgct tggtttgtac
    41281 tcgtttgttg ccatttctaa gttagctgca tagctagact cacttgagta agcaatggta
    41341 tcttcaccag agactatcca tttgagcaat tctgccttga tttcttcttg cacttctgca
    41401 ggaatttcgt caaatgaggc aactgacttg tccaagacaa cccagcggtc aaggtctgta
    41461 cgagcagatg taatggccat aaattcttgg ctatccttac cacccatggc tccaccgtca
    41521 ccaataatag ccttgaagtc taaaccacta cgagtgaaaa tacgctcata ggctgctttg
    41581 tactcatcat aaacactatc caaactatca tagttagcgt ggaaactata agcatccttc
    41641 atgataaact cacgtgtacg aagaagtcca ttacgtgggc gtttttcatc acgatacttg
    41701 ggctgaattt gataaaggtt gagtggcaat tgcttgtaag atttaacaga atcacggaca
    41761 atagctgtaa aggtttcttc gtgagttgga cctaagataa agtctgattt ttcacggttt
    41821 ttcagtttgt aaaggtcttc accataggtt tcgtaacgac ctgattcacg ccacaattct
    41881 gcactaagaa gggctggagc caacatctca acagcaccaa tcttttcgaa ttcttggcgc
    41941 atgatgtttt tagctttttc aatcacacgg ttggcaagtg gtagataaga ataaacacct
    42001 gctgaaactt ggcgaacata accagcacgc aacataagag catggctgat aacttgagca
    42061 tcgcttggca tttcgcgaag cgttgggata ggcattttac tttgtttcat aatattcctc
    42121 gattatctaa aaaagagtcg cataatgtca ttccaagtca cagcaatcat caagacaacc
    42181 atgatgacca ctccggccaa ggtgacatag gtttcaattt cttgtttcaa tggtttgcgg
    42241 cggatggctt ctaggatatt gagcacaatc ttaccaccat ccaaggctgg aatcggaata
    42301 agattaaaaa tcccaatatt gatggaaatc attgccaaga agtacaagat attttcaatt
    42361 ccatttttag cagcatcact acttgcctta aagatagcaa caggtccacc caacttgttc
    42421 aaatccggtt ggaaaatcag atttttcaga gctgagagaa ttcggagagc tgagtcagca
    42481 gcagttgtaa aaccacctac aaacatggat agaaaatctg acttaacccc cggttgaaca
    42541 cctagaaggt aacgaccttg actatcttcg ggtgtaacag tgacttgttt gtcactcccc
    42601 ttttcagaaa tagtcacatc caaagtcggt gccgtcttat ctttggtttc tgtttccaca
    42661 gcttggatca agctttccca gttgctaacc tcatgtgagc caatcttggt aatttgtgcc
    42721 gtttctggta ctcctacctt ggccaaggca ccttggggca tgatatggaa ctgattggta
    42781 tcaacatctc tgacaccacc ctgcataaag attaaaaccc aaaaaacaac gacacctaag
    42841 ataaaattgt tcataggacc tgcaaaattg gtaatcagtt tgccccagat agtcgcattt
    42901 tgatattgaa catctaaagg tgcaatccga acctcagtac catctgcttc cacaaccgtt
    42961 gcatcgtgat ccactgcaaa tgttttttct tcttccagaa ccaatccttt gataaagagc
    43021 ttgtcttcaa aatcaaactg ggtcacctgc atagggaggg ctgtttgatc caatttttta
    43081 cctgagagat tgatgcgttt aaccttacca tcatcagcaa gtgtcaaact aacaggcgtt
    43141 cctgtcttga tttcagttgt atcatcaccc caaccggcca tgcggacata gccacccaga
    43201 ggcaaaattc gaatggtata ggccgttcca tccttaccaa tgtgagcaaa aattttaggt
    43261 cccataccga tggcaaattc acgtactaaa atccctgatt tcttggcaaa gtagaagtgc
    43321 ccgaactcgt gcaccactac aataatcccg aaaaccagaa taaaggttaa aattccgagc
    43381 atagcgtttc ctccgtcttt tgattaaaag agtccaaata agtgcatgat tggaaataca
    43441 agcaacatac tatcgaaacg atccaaaaca ccaccatgtc cagggataaa tttcccagaa
    43501 tccttaacac caaaatgacg tttgatcgaa ctttctagta aatcaccaaa ttgtccagca
    43561 atgctaaaga aaatagcaaa gactgacatc ttgtaaattc catatggaag agcaactgta
    43621 ctgtcaacta tcataaagat aatggttact aaaattgctc ctaaaatacc acccaaggca
    43681 ccctcaaggg ttttattagg cgataccctt ggtgctaact ttcgtttccc atagttcatc
    43741 ccaacaagat aggcaccact gtctgtcgcc cagacgatac acaaggctaa gagagccttg
    43801 tccaaacctg caacacgagc atctagtaaa gcattaaatc caaagcccac gtagaagctc
    43861 atagcaagag ggaaaaccgc atcctcaatc gtataagact tgctaaaaac ggtcgttcct
    43921 aacatgattg aaatcaaaac actataggca accacattcc catcaactgg caaaaaagtc
    43981 aggtaattct ccaagggaat ggtcaatgca aaggttgcaa agagggtcaa gaggccctcc
    44041 atcgtcatgg tctctagacc tctcatcttc aaaagttcat gcatggctag catggctatg
    44101 attccgattg ctatctgaag caagaggccc ccaatcatta aaattggtag gaaaatagcc
    44161 agggcaatcc ctgcaaacaa ggttcttttc tgtaaatcct gggtcatatt tcctcctaaa
    44221 ctcctccaaa tcggcgatgg cgacgattat aggcaagaat agcttcctgc aaggctgctt
    44281 cgtcaaaatc aggccataag gtgtccgtaa aataaagctc actataggct ccctgccatg
    44341 gaaggaaatt gctcaaacgt aattctccac tagtacggat aatcaagtct gggtctcgta
    44401 agtccttagg caaatgctga gtaaagagat agttaccaat caattcctct gtgatgtcac
    44461 ctgggttgat tttggcatct aaaacatcct gggaaatcaa cttaagcgcc tgtgtaatct
    44521 cagcacgtcc accatagtta agagcaaaat taagaatcaa tcctgtgttg ttcttagtca
    44581 attcctcagc cttggttaaa gcttcaaagg tttgcttagg caggcggtct gtctccccaa
    44641 tcatttgaat cttaacatta ttcgcatgta gttccgggac ataattatca taaaactcta
    44701 ctggcaagtt catgataaac ttgacttcct gatctggacg ggtccagttt tccgtagaaa
    44761 aagcatagac cgtaataacc ttgacgccca gtttgttggc tgccttggtc acggtttgca
    44821 atgcttccat gcccgccttg tgtccaaaaa ctcgcggttg catacgtttt ttagcccaac
    44881 ggccattgcc atccatgatg atgccgatat gagcaggaac ctgtgtcgga acctctactt
    44941 ccacagcctt atctttctta aaaaatccaa acatgatctt attcctattc aaaaatctat
    45001 cgtttcatta taccatattt ccccattttc ttctatcact aagctattta ttctcaggca
    45061 ccaagcccat ttttcaaaaa aataagccgc ctgattgggc gactttattt ttatagggag
    45121 attattatga aaaagtttta ggagtttaag ttaaggtctt cttaacttat gaacttagtg
    45181 tacactccct agcttaaagt ttccttaagt atttttaaaa atcaaatttt tccatttctc
    45241 ctgccaattt ttcttggata aacgtgtttg atagagttcc attcggtctt cattttctaa
    45301 gaaatgagga gttggacgaa cttgaaaatt caaaatatcc tccaaaccat aaggtgcata
    45361 gagttcaaaa tctgattctt cattcaagcg cagtccaact gtcgtacacc gttctggata
    45421 cttactcata gcatcacgag aactggtata ggaagcagtg tgaggactgt gctgatgcat
    45481 atagacctga tttttcaatt cccactggta ctgaggaaaa tcctctcgca gctttttctc
    45541 cagtaataag gtttcctcat aagaaaaatc tggatcaaag aaaatcacat ctatatctgt
    45601 ttcatgatca aaaggggatt tgtctgacaa aagattccaa atgaaatttc tgacagaacc
    45661 tgctgccaac cacgagtctt tcagaccaag gtctcggatg atcgtcagaa tggccatcat
    45721 atctggattt tctctaaaag cctctaagat ttcttgctta tttttcactg tattcataac
    45781 ctaagtgctc atatgcctta gcagtcgcca cccgtccaga ccgtgtccgc atgataaaac
    45841 ctttttgaat caagtaaggc tcatacatat cttcaactgt ctcacgctct tcggcgatat
    45901 tcacagaaag agttcctaga ccaacaggtc ctccactgta catctcaatc atggtacgaa
    45961 ggattttttg atccacatag tccaaacctt catggtcaac atccagcata gtcaaagcct
    46021 tatcggtaat aatatcatca attaccccat tccccattat ctgggcaaaa tcgcgcacgc
    46081 gcttgaggag acgattggca atacgagggg tcccacgact acgtagggcc aactcagatg
    46141 ctgcctcatg agtgatttcc atctcaaaaa tatctgccgt ccgctcgaca atttctgtca
    46201 agccagcatg ggcataatac tccatatggc ctgtaatccc aaaacgtgcc cgtagcggat
    46261 tggagagcat accagcccga gtcgtcgcac caatcaaggt aaaaggtggt aactccaaat
    46321 gaacactacg actaccctca ccagccccaa tcataatatc gatgtagaag tcctccatag
    46381 cactataaag cacctcttcc actgacattg gcaaacgatg gatctcatca ataaaaagta
    46441 catccccagg ctctaactca ttcaaaatag ctaccagatc tccggctttt tcaatgactg
    46501 gacccgacgt ctgcttaaga ttgactccca gttcgttggc aataacaaag gccatggtcg
    46561 ttttcccgag acctggaggc ccaaataaga gcacatgatc cagcgcttca tcccgcattt
    46621 tggcagcttc aataaagatt tgtagctggt ccttgacctt atcctgtccg atatattcac
    46681 gtaaatactg aggacggagc gtgcgttcta ctaactcctc atcccccatt atctcattat
    46741 ctaaaattct actcatggct ctattatatc aaaaaaccaa gccacaaaca aaaaagccac
    46801 ctgattgggt gactcctaag tttagcactt atgtggtata atattctacg acactgctac
    46861 accgcctacg aaaggaggtg agatagccca tgatggaatt agtactcaaa actatcatcg
    46921 gaccaattgt ggtcggtgtc gttcttcgta tagtcgataa atggctaaac aaggacaaat
    46981 agtgtcaaaa aagaccccaa gcttatttgg tcgtgagctt ggggtctttt ctagcctatg
    47041 atatagaact agtactcaat tcctttttat tatcccatag ttcacgaatt ttgtcaaagg
    47101 tttacatttt cttcaaccgc tgtacgacaa gacggttaag attaagagaa cgttagggat
    47161 tctatcaatt tcatagaaat tttgatttcg taaacgaaga gacaatctta catgtcactt
    47221 ctcatttaat acgccactac tagacaagca aaatcattat tacagtagtt ccagttcttc
    47281 aattaacagt cacttacaat caaattgagt ttgaactagc tgaagcgacc acagacctat
    47341 ttcttagtta tattcgctaa aaaagtcccc gccaattccc cgaccaaaat ccgaaaaata
    47401 ccgaaaaata tcgaaaaatt atttttagaa tagtccccaa aagcctgaaa tagagctaaa
    47461 aaactccacc tgattgggtg gagttaaggg agattattat gaaaaagaaa agtttaggat
    47521 tttattaaat aaagttagga ggtctttatt taataactac atgatacaag acgaaactta
    47581 aaactagctt aacttttcta aaattttact attttgcaaa aaatttc
//
LOCUS       DAVHIZ010000011        46072 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.011, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000011 DAVHIZ010000000
VERSION     DAVHIZ010000011.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 46072)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 46072)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..46072
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.011"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(594..1007)
                     /gene="ndk"
                     /locus_tag="VVO18_000609"
     CDS             complement(594..1007)
                     /gene="ndk"
                     /locus_tag="VVO18_000609"
                     /EC_number="2.7.4.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000438285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-diphosphate kinase"
                     /protein_id="HEU5585812.1"
                     /translation="MEQTFFIIKPDGVKRGLVGEVLKRIEQRGFTIEKLEFRSQVSEE
                     LIDQHYQDLVGQSFYPPIREFMTSGPVLVGVISGPKVIETWRTMMGATRPEEALPGTI
                     RGDFAKAAGENEIIQNVVHGSDSEESAKREIALWF"
     gene            complement(1118..4795)
                     /gene="rpoC"
                     /locus_tag="VVO18_000610"
     CDS             complement(1118..4795)
                     /gene="rpoC"
                     /locus_tag="VVO18_000610"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000228741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta'"
                     /protein_id="HEU5585813.1"
                     /translation="MVDVNRFKSMQITLASPSKVRSWSYGEVKKPETINYRTLKPERE
                     GLFDEVIFGPTKDWECACGKYKRIRYRGIVCDRCGVEVTRTKVRRERMGHIELKAPVS
                     HIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKDTPLEHKSIMTEREYRERLR
                     EYGYGSFVAKMGAEAIQDLLKQVDLEKEIAELKEELKTATGQKRVKAIRRLDVLDAFY
                     KSGNKPEWMILNILPVIPPDLRPMLQLDGGRFASSDLNDLYRRVINRNNRLARLLELN
                     APGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSHMLKGKQGRFRQNLLG
                     KRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVARDIVQNVKAAKRLVE
                     RGDERIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLVCEAYNAD
                     FDGDQMAIHVPLSEEAQAEARILMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEEA
                     GREGEGMVFKDRDEAVMAYRNGYVHLHSRVGIATDSLNKPWTEEQRHKVLLTTVGKIL
                     FNDIMPEGLPYLQEPNNANLTEGVPAKYFLPLGGDIKEAISNLELNPPFKKKNLGNII
                     AEIFKRFRTTETSALLDRMKNLGYHHSTLAGLTVGIADIPVVDDKAEIIEESHKRVEQ
                     ITKQFRRGMITDDERYNAVTAEWRAAREKLEKRLIANQDPKNPIVMMMDSGARGNISN
                     FSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSG
                     YLTRRLVDVAQDVIIREDDCGTDRGLLIRSIAEGKEMIESLEERLNGRYTKKTVKHPE
                     TGAVIIGPNELITEDKAREIVNAGVEEVTIRSVFTCNTRHGVCRHCYGINLATGDAVE
                     VGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNTDITQGLPRVQEIFEARNPKGEAVI
                     TEVKGQVTAIEEDASTRTKKVFVKGETGEGEYVVPFTARMRVEVGGQVARGAALTEGS
                     IQPKRLLAVRDVLSVETYLLGEVQKVYRSQGVEIGDKHIEVMVRQMIRKVRVMDPGDT
                     DLLMGTLMDINDFTDANKDVLIAGGVPATGRPVLMGITKASLETNSFLSAASFQETTR
                     VLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPHAVNEEEYLNPPVEEEG
                     NEETTEVVVDTAVETVEETVE"
     gene            complement(4828..8439)
                     /gene="rpoB"
                     /locus_tag="VVO18_000611"
     CDS             complement(4828..8439)
                     /gene="rpoB"
                     /locus_tag="VVO18_000611"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000907130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEU5585814.1"
                     /translation="MAGHDVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKAFLDHG
                     LKEVFEDVLPISNFTDTMELEFVGYEIKEPKYTLEEARIHDASYSAPIFVTFRLINKE
                     TGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGS
                     TVIPNRGAWLELESDSKDITYTRIDRTRKIPFTTLVRALGFSGDDEIFDIFGDSELVR
                     NTVEKDIHKNPMDSRTDEALKEIYERLRPGEPKTAESSRSLLVARFFDPRRYDLAAVG
                     RYKINKKLNVKTRLLNQTIAEPLVDPETGEILVEAGTIMTRSVIESIESHLDGDLNKI
                     VYIPNDAAVVTEPVVLQKFKVVAPTDPDRVVTIIGNANPDDKVRTVTPADILAEMSYF
                     LNLAEGLGRVDDIDHLGNRRIRAVGELLANQVRLGLSRMERNVRERMSVQDNEVLTPQ
                     QIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVR
                     DVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFVQTPYRKVDRETGVVTNEIV
                     WLTADEEDEYTVAQANSRLNEDGTFAEKIVMGRHQGVNQEYPANIVDYMDVSPKQVVA
                     VATACIPFLENDDSNRALMGANMQRQAVPLINPQAPYVGTGMEYQAAHDSGAAVIAQY
                     DGKVTYADADKVEVRREDGSLDVYHIQKFRRSNSGTAYNQRTLVKVGDVVEKGDFIAD
                     GPSMENGEMALGQNPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEYESETRDT
                     KLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERL
                     LHAIFGDKSREVRDTSLRVPHGADGVVRDVKIFTRVNGDELQSGVNMLVRVYIAQKRK
                     IKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHL
                     GMAARTLGIHIATPVFDGASSEDLWSTVKEAGMDSDAKTILYDGRTGEPFDNRVSVGV
                     MYMIKLHHMVDDKLHARSVGPYSTVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVL
                     QEILTYKSDDINGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDQ
                     EVELRDLDEGMDEDVIHVDDLEKAREKAAQEAKAAFEAEEAEKATKAEATEEAAEQE"
     gene            8855..8925
                     /locus_tag="VVO18_000612"
     tRNA            8855..8925
                     /locus_tag="VVO18_000612"
                     /product="tRNA-Cys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:8887..8889,aa:Cys,seq:gca)
     gene            complement(9123..10454)
                     /locus_tag="VVO18_000613"
     CDS             complement(9123..10454)
                     /locus_tag="VVO18_000613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000390004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HlyC/CorC family transporter"
                     /protein_id="HEU5585815.1"
                     /translation="MEDPSSQNLLLQFVLLFILTVLNAFFSATEMAMVSLNRARVEQK
                     AEEGDRRYIRLLKVLENPNHFLSTIQVGITLITILSGASLTDTLGRVIASWLGNGETA
                     QAVATFLSLAFLTYISIVFGELYPKRIALNLKDALAIRTAPIIIGIGKLVSPFVWLLA
                     ASTNFLSHLTPMSFDDADEKMTRDEIAYMLTNSEETLDADEIEMLQGVFSLDELMARE
                     VMVPRTDAFMVDIQDDSQAIIQSILKQNYSRIPVYDGDKDNVIGIIHTKSLLKAGFVD
                     GFDNIVWKRILQDPLFVPETIFVDDLLKELRNTQRQMAILLDEYGGMAGLVTLEDLLE
                     EIVGEIDDETDKAAIDVHQIGEDTYIVQGTMTLNDFNNYFDVELESDDVDTIAGYYLT
                     GVGTIPTTEKLSYELVSQNKQFILTNDKVKNGRVTKVKVQITEVEIEEETE"
     gene            complement(10745..11569)
                     /gene="endA"
                     /locus_tag="VVO18_000614"
     CDS             complement(10745..11569)
                     /gene="endA"
                     /locus_tag="VVO18_000614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-entry nuclease EndA"
                     /protein_id="HEU5585816.1"
                     /translation="MNKKTRQTLIGLLVLLLLSTGSYYIKQMQSAPNSPKTNLSQKKQ
                     APEAPSQALAESVLTDAVKSQIKGSLEWNGSGAFIVNGNKTNLDAKVSSKPYADNKTK
                     TVGKETVPTVANALLSNATRQYKNRKETGNGSTSWTPPGWHQVKNLKGSYTHAVDRGH
                     LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEYSTGQNYYESKVRKALDQNKRV
                     RYRVTLYYASNEDLVPSASQIEAKSSDGELEFNVLVPNVQKGLQLDYRTGEVTVTQ"
     gene            complement(11608..11796)
                     /locus_tag="VVO18_000615"
     CDS             complement(11608..11796)
                     /locus_tag="VVO18_000615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="HEU5585817.1"
                     /translation="MNKKSSYVVKRLLLVIIVLILGTLALGIGLMVGYGILGKGQDPW
                     AILSPAKWQELIHKFTGN"
     gene            complement(11789..13072)
                     /gene="murA"
                     /locus_tag="VVO18_000616"
     CDS             complement(11789..13072)
                     /gene="murA"
                     /locus_tag="VVO18_000616"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEU5585818.1"
                     /translation="MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQ
                     NVPILSDVFIMNQVVGGLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVL
                     GPILARVGHAKVSMPGGCTIGSRPIDLHLKGLEAMGVKISQTAGYIEAKAERLHGAHI
                     YMDFPSVGATQNLMMAATLADGVTVIENAAREPEIVDLAILLNEMGAKVKGAGTETIT
                     ITGVEKLHGTTHNVVQDRIEAGTFMVAAAMTGGDVLIRDAVWEHNRPLIAKLLEMGVE
                     VIEEDEGIRVRSQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFEN
                     RFQHLEEMRRMGLHSEIIRDTARIVGGQPLQGAEVLSTDLRASAALILTGLVAQGETV
                     VGKLVHLDRGYYGFHEKLAQLGAKIQRIEASDEDE"
     gene            complement(13096..13326)
                     /locus_tag="VVO18_000617"
     CDS             complement(13096..13326)
                     /locus_tag="VVO18_000617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014017351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1146 domain-containing protein"
                     /protein_id="HEU5585819.1"
                     /translation="MVQLLFTLSSHMLFIYVSFYLLKDLVRWEKVLKVTAENTRKVRV
                     LVAFFSIVIGYILSSFFISLYHLWQEALRGLL"
     gene            complement(13384..14421)
                     /locus_tag="VVO18_000618"
     CDS             complement(13384..14421)
                     /locus_tag="VVO18_000618"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PDZ domain-containing protein"
                     /protein_id="HEU5585820.1"
                     /translation="MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLK
                     VNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFTDIRSAQETTGGSSDVEFMRINQ
                     FYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
                     DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVIS
                     NVPISFSTAGIGGPSAGLMFSLAIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGID
                     KKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAKTIKTDMKIVPVKTL
                     QDAIDYLKNNP"
     gene            complement(14405..14893)
                     /gene="coaD"
                     /locus_tag="VVO18_000619"
     CDS             complement(14405..14893)
                     /gene="coaD"
                     /locus_tag="VVO18_000619"
                     /EC_number="2.7.7.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pantetheine-phosphate adenylyltransferase"
                     /protein_id="HEU5585821.1"
                     /translation="MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQ
                     GFLPLENRKRGLEKALGHLENVEVVASHDKLVVDVAKRLGATFLVRGLRNAADLQYEA
                     SFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACHVPESILEEIRNEK
                     KD"
     gene            complement(14883..15422)
                     /gene="rsmD"
                     /locus_tag="VVO18_000620"
     CDS             complement(14883..15422)
                     /gene="rsmD"
                     /locus_tag="VVO18_000620"
                     /EC_number="2.1.1.171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(966)-N(2))-methyltransferase
                     RsmD"
                     /protein_id="HEU5585822.1"
                     /translation="MKIISGIYGGRPLKTLEGKTTRPTSDKVRGAIFNMIGPYFEGGR
                     VLDLYAGSGGLSIEAVSRGMSSAVLVERDRKAQTIVAENIQMTKEVGKFQLLKMDAER
                     ALEQVSGEFDLVFLDPPYAKEQIVADIEKMAERELFSEDVMVVCETDKAVELPEEIAC
                     LGIWKEKIYGISKVTVYVR"
     gene            complement(15487..16479)
                     /locus_tag="VVO18_000621"
     CDS             complement(15487..16479)
                     /locus_tag="VVO18_000621"
                     /EC_number="6.3.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016502595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate--ammonia ligase"
                     /protein_id="HEU5585823.1"
                     /translation="MKKSFIHQQEEISFVKNTFTQYLKDKLEVVEVQGPILSKVGDGM
                     QDNLSGVENPVSVKVLQIPDATYEVVHSLAKWKRHTLARFGFGEGEGLFVHMKALRPD
                     EDSLDATHSVYVDQWDWEKVIPNGKRNIVYLKETVEKIYKAIRLTELAVEARYDIESI
                     LPKQITFIHTEELVERYPDLTPKERENAICKEFGAVFLIGIGGELPDGKPHDGRAPDY
                     DDWTSESENGYKGLNGDILVWNESLGGAFELSSMGIRVDEETLRRQVEITGDEDRLEL
                     EWHKSLLNGLFPLTIGGGIGQSRMAMFLLRKRHIGEVQTSVWPQEVRDTYENIL"
     gene            complement(16590..17273)
                     /locus_tag="VVO18_000622"
     CDS             complement(16590..17273)
                     /locus_tag="VVO18_000622"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545711.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="HEU5585824.1"
                     /translation="MNHTIIHDRAGLNQFYAKVYAFVGLGIGLSALVSGLMLTVFQSQ
                     LVYLLMQGRLWLTIATFAELALVFVASSMASRNSPAALPVFLLYSVLNGFTLSFVVAF
                     YTPGTVLSAFVSSALLFFVMAAVGIFTKKDLSGIGRAMMAALIGLLIAMVVNIFLASG
                     FFDYMISVAMVLVFSGLIAWDNQKIRLAYEQSQGRVATGWVVSMALSIYLDFINLFLS
                     ILRIFGRND"
     gene            complement(17329..18069)
                     /locus_tag="VVO18_000623"
     CDS             complement(17329..18069)
                     /locus_tag="VVO18_000623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA methyltransferase"
                     /protein_id="HEU5585825.1"
                     /translation="MTIITSKANSVVKNAKKLHQKKYRKSAYLIEGWHLFEEAVQAGV
                     TIEKIFALENYRDQLAAFPQTVWISEDILLDLADSQTPQGIVAVVQKEEVGQADLSQG
                     KFLFLEDVQDPGNVGTIIRTADAAGFTGVIVSDKSADIYSLKTLRSMQGSHFHLPIYR
                     MTSQALLDETKKVAIPVLATTLSKDSVDYRELPSIENFVLVMGNEGQGISPLMAESAD
                     QLVHISMKGQAESLNVAVAAGILIFHLS"
     gene            18103..18381
                     /locus_tag="VVO18_000624"
     CDS             18103..18381
                     /locus_tag="VVO18_000624"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001174612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acylphosphatase"
                     /protein_id="HEU5585826.1"
                     /translation="MQKVRMIAQGRVQGVGFRWGVYSLALEIGGITGRVWNNDDGTVE
                     ILAQADSSAIMAKFIQEIRKGPTPFSKVSYLDVKLSNFPPYSDFKIAN"
     gene            18459..19385
                     /gene="yidC"
                     /locus_tag="VVO18_000625"
     CDS             18459..19385
                     /gene="yidC"
                     /locus_tag="VVO18_000625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEU5585827.1"
                     /translation="MKSIKRFAFSAMGVAMLLVLTGCVNVDKTTGQPTGFIWNTIGAP
                     MAEAIKYFATDKGLGFGVAIIIVTIIVRLIILPLGIYQSWKATLHSEKMNALKHVLEP
                     HQTRLKEATTQEEKLEAQQALFAAQKEHGISMFGGVGCFPILLQMPFFSAIYFAAQHT
                     EGVAQASYLGIPLGSPSMILVACAGVLYYLQSLLSLHGVEDEMQREQIKKMIYMSPLM
                     IVVFSLFSPASVTLYWVVGGFMMILQQFIVNYIVRPKLRKKVREELAKNPPKASAFSK
                     PSGRKDVTPEQPTAITSKKKHKNRNAGKQRSR"
     gene            complement(19460..20254)
                     /gene="pflA"
                     /locus_tag="VVO18_000626"
     CDS             complement(19460..20254)
                     /gene="pflA"
                     /locus_tag="VVO18_000626"
                     /EC_number="1.97.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001288284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate formate lyase-activating protein"
                     /protein_id="HEU5585828.1"
                     /translation="MSEETIDYGQVTGMVHSTESFGSVDGPGIRFIVFLQGCHMRCQY
                     CHNPDTWAMESNKSRERTVDDVLTEALRYRGFWGNKGGITVSGGEALLQIDFLIALFT
                     KAKEQGIHCTLDTCALPFRNKPRYLEKFDKLMAVTDLVLLDIKEINEEQHKIVTSQTN
                     KNILACAQYLSDIGKPVWIRHVLVPGLTDRDDDLIELGKFVKTLKNVDKFEILPYHTM
                     GEFKWRELGIPYSLEGVKPPTADRVKNAKKLMDTESYQDYMKRVHG"
     gene            complement(20380..21630)
                     /locus_tag="VVO18_000627"
     CDS             complement(20380..21630)
                     /locus_tag="VVO18_000627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856498.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopimelate decarboxylase"
                     /protein_id="HEU5585829.1"
                     /translation="MKTPFINREELEAIVAEFPTPFHLYDEKGIREKARAVNQAFSWN
                     KGFKEYFAVKATPTPAILKILQEEGCGVDCSSYVELLMSHKLDFLGSEIMFSSNNTPD
                     KEYAYARELGATINLDAFEDIEHLERVAGIPEIISCRYNPGGVFELGTDIMDNPEEAK
                     FGMTKDQLFEAFAILKEKGAKTFGLHSFLASNTVTHLYYPELARQLFELAVEIKEKLG
                     ISLDFINLSGGIGVNYRPDQEPNDIALIGEGVRKVYEEVLTSAGLGQVKIFTELGRFM
                     LAPHGALVTRVTHKKETYRTYLGVDASAVNLMRPAMYGAYHHISNVTHPDGPAEAVDV
                     VGSLCENNDKFAVNRELPHTEIGDLLVIHDTGAHGFSMGYQYNAKLRSAEILYTEEGK
                     ARQIRRAERPEDYFATLYGFDFEE"
     gene            complement(21697..22524)
                     /gene="purR"
                     /locus_tag="VVO18_000628"
     CDS             complement(21697..22524)
                     /gene="purR"
                     /locus_tag="VVO18_000628"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004242125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pur operon repressor"
                     /protein_id="HEU5585830.1"
                     /translation="MKLRRSDRMVVISNYLINNPYKLTSLNTFAEKYESAKSSISEDI
                     VIIKRAFEEIEIGHIQTVTGAGGGVIFTPSISSQDAKEMVEDLRTKLSESDRILPGGY
                     IYLSDLLSTPAILKNIGRIIAKSFMDQKIDAVMTVATKGVPLANAVANVLNVSFVIVR
                     RDLKITEGSTVSVNYVSGSSGDRIEKMFLSKRSLKAGSRVLIVDDFLKGGGTVNGMIS
                     LLREFDSELAGVAVFADNAQEEREKQFDYKSLLKVTNIDVKNQAIDVEVGNIFDEDK"
     gene            complement(22791..23732)
                     /locus_tag="VVO18_000629"
     CDS             complement(22791..23732)
                     /locus_tag="VVO18_000629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260511.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exoribonuclease YhaM family protein"
                     /protein_id="HEU5585831.1"
                     /translation="MKISHMKKDELFEGFYLIKSADLRQTRAGKNYLAFTFQDDSGEI
                     DGKLWDAQPHNIEAFTAGKVVHMKGRREVYNNTPQVNQITLRLPQAGEPNDPADFKVK
                     SPVDVKEIRDYMSQMIFKIENPVWQRIVRNLYTKYDKEFYSYPAAKTNHHAFETGLAY
                     HTATMVRLADAISEVYPQLNKSLLYAGIMLHDLAKVIELTGPDQTEYTVRGNLLGHIA
                     LIDSEITKTVMELGIDDTKEEVVLLRHVILSHHGLLEYGSPVRPRIMEAEIIHMIDNL
                     DASMMMMSTALALVDKGEMSNKIFAMDNRSFYKPDLD"
     gene            complement(23722..24978)
                     /locus_tag="VVO18_000630"
     CDS             complement(23722..24978)
                     /locus_tag="VVO18_000630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombination protein RmuC"
                     /protein_id="HEU5585832.1"
                     /translation="MESLLILLLIANLAGLFLIWQRQDRQEKHLSKSLEDQADHLSDQ
                     LDYRFDQARQASQLDQKDLEVVVSDRLQEVRIELHQGLTQVRQEMTDNLLQTRDKTDQ
                     RLQALQESNEQRLEQMRQTVEEKLEKTLQTRLQASFETVSKQLESVNRGLGEMQTVAR
                     DVGALNKVLSGTKTRGILGELQLGQIIEDIMTPAQYEREYATVENSSERVEYAIKLPG
                     QGDQEYVYLPIDSKFPLADYYRLEEAYETGDKDEIERCRKSLLASVKRFARDIRNKYI
                     APPRTTNFGVLFVPTEGLYSEIVRNPVFFDNLRREEQIIVAGPSTLSALLNSLSVGFK
                     TLNIQKSADHISKTLASVKTEFGKFGGILVKAQKHLQHASGNIDELLNRRTIAIERTL
                     RHIELSEGEPALDLLHFQENEEEYED"
     gene            complement(24980..25642)
                     /locus_tag="VVO18_000631"
     CDS             complement(24980..25642)
                     /locus_tag="VVO18_000631"
                     /EC_number="2.7.6.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000006147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine diphosphokinase"
                     /protein_id="HEU5585833.1"
                     /translation="MSEYKLSENNWTRVAVFAGGNRGHYRTDFDAFVGVDRGSLWVLE
                     EDLPLALAVGDFDSVTAEERQVIQKRAQYFVQARPEKDDTDLELALLTIFEQNPQAQV
                     TIFGALGGRIDHMLANVFLPSNPKLAPYMRQIEIEDGQNLIAYCSEGTSQLEPRSDYD
                     YLAFMPVRDSQLTILGAKYELTEENFFFKKVYASNEYIDREVSVTCPDGYVVVLHSKD
                     RR"
     gene            complement(25605..26261)
                     /locus_tag="VVO18_000632"
     CDS             complement(25605..26261)
                     /locus_tag="VVO18_000632"
                     /EC_number="5.1.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="HEU5585834.1"
                     /translation="MSQYKIAPSILAADYANFEREIKRLEATGAEYAHIDIMDSHFVP
                     QISFGAGVVESLRPHSKMVFDCHLMVSNPEHHLEDFARAGADIISIHVEATPHIHGAL
                     QKIRSLGVKPSVVINPGTPVEAIKHVLHLVDQVLVMTVNPGFGGQAFLPETMDKVREL
                     VALRQEKGLNFEIEVDGGIDDQTIAQAKEAGATVFVAGSYVFKGEVNERVQTLRKQLD
                     "
     gene            complement(26272..27150)
                     /gene="rsgA"
                     /locus_tag="VVO18_000633"
     CDS             complement(26272..27150)
                     /gene="rsgA"
                     /locus_tag="VVO18_000633"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466872.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="HEU5585835.1"
                     /translation="MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVD
                     FSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHK
                     GIHPIVYISKMDLLEDRGELDFYQQTYGDIGYDFVTSKEELLPLLTGKVTVFMGQTGV
                     GKSTLLNKIAPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVS
                     RAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGTIATFRFDNYLQFLSEI
                     ENRRETYKKVSKKIPK"
     gene            complement(27152..28024)
                     /gene="rsmA"
                     /locus_tag="VVO18_000634"
     CDS             complement(27152..28024)
                     /gene="rsmA"
                     /locus_tag="VVO18_000634"
                     /EC_number="2.1.1.182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA
                     (adenine(1518)-N(6)/adenine(1519)-N(6))-
                     dimethyltransferase RsmA"
                     /protein_id="HEU5585836.1"
                     /translation="MRIADYSVTKAVLERHGFTFKKSFGQNFLTDTNILQKIVDTAEI
                     DDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILADTLRDFDNVTVVNEDIL
                     KVDLAQHIQNFKNPDLPIKVVANLPYYITTPILMHLIESGIPFCEFVVMMQKEVADRI
                     SAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRPEPAVAVED
                     ENFFFKVSKASFTHRRKTLWNNLTGYFGKTEEVKDKLTKALDQAGLSPSVRGEALSLA
                     EFAGLADALKGQGL"
     gene            complement(28410..28568)
                     /locus_tag="VVO18_000635"
     CDS             complement(28410..28568)
                     /locus_tag="VVO18_000635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333268.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585837.1"
                     /translation="MCEKIRIRRVSDYPSARGGLEDILIMENMTNHLLLVQIRVHGYL
                     LDFASIEG"
     gene            complement(28561..29202)
                     /locus_tag="VVO18_000636"
     CDS             complement(28561..29202)
                     /locus_tag="VVO18_000636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585838.1"
                     /translation="MIDIQGLEKKFNDRAIFSGLNLKLEKGKVYALIGKSGSGKTTLL
                     NILGKLEKIDGGRVLYQGKDLKTIPTREYFRDQMGYLFQNFGLLENQSIKENLDLGFV
                     GQKISKVERLERQVGALEKVNLGYLDLEQKIYTLSGGEAQRVALAKTILKNPPLILAD
                     EPTAALDPENSEEVMNLLVDLKDENRIIIIATHNPLVWNKADEIIDMRKLAHV"
     gene            complement(29204..31234)
                     /locus_tag="VVO18_000637"
     CDS             complement(29204..31234)
                     /locus_tag="VVO18_000637"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000825281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU5585839.1"
                     /translation="MKRLFILISMVLVSLYMVITSVDHREEILFGNYPSVDVTGMMIN
                     QPVASREEVTEVLSHLAVEHNSLIARRIVEPNEAGETLFTYATYGEGELPEGLTISSK
                     ESAETSDLLGSYLIVSGSLDGVSLQTTLKELGYQGFVSNGEDPFSIVLLLAATPMVLL
                     SLAIFLLTFMSLTLIYRIKSLRQAGIRLIAGESLFGVALRPVLEDVRQFICSVLVSSL
                     LGLGILWYQGALFMATVQLVIIALLLYGLTLAGISTLLSVVYLLGLQENSLVDLLKGK
                     LPLKRMMTLMMVGQLLAVLVVGLSATALLPNYREMQEMEKASDKWSQSSDRYRLSFGW
                     SSAFADEEGMRKDNREWQTFTEERLANTDSFYIMSNVDNFSDGVEVDLDGNRLSDYTP
                     SGNVIYVSPRYLIEEKITVSSEFMDKMQNLSEGEFGLILPESLREQSAYYQGLFTDYL
                     QNFSSESVEVTSQKHYLPQVRLAFTETGQERFLYNDGYKTTRQYLKDPIIVVLTPQAT
                     GTRPVAGMLWGTTANSALKLDRYGDSITALKEQGLYHKVSYLVKSQLFFAKVLNDKRV
                     EFYSLLIGTILTLSTAILLFDSMNLLYFEQFRRELMIKRLAGMTIYELHGKYLLAQGG
                     VLLLGLVLSSILTRDGLISALVVALFTLNALLILVRQDKKEEAGSMAVLKGK"
     gene            complement(31502..32401)
                     /locus_tag="VVO18_000638"
     CDS             complement(31502..32401)
                     /locus_tag="VVO18_000638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5585840.1"
                     /translation="MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPS
                     LPKLDYIARRLGVPVYSLMPDFSALPPAYLELKYQILREPIYGKEEEYDKKEACLEEI
                     YKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEVYSTNDMLL
                     IRLFFYQMLIRKDLAKFINQIEELMLFLLEQKKVTKLENFFIIRDTLISGMCCLEKVG
                     VTDCFNDYLSCLQEIMDKTQDYQKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQ
                     LIGDEFLVKKLTEEWQEDVKKYL"
     gene            complement(32473..33033)
                     /gene="rnmV"
                     /locus_tag="VVO18_000639"
     CDS             complement(32473..33033)
                     /gene="rnmV"
                     /locus_tag="VVO18_000639"
                     /EC_number="3.1.26.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease M5"
                     /protein_id="HEU5585841.1"
                     /translation="MKEKISQVIVVEGRDDTVNLKRYFDVETYETRGSAINDQDIERI
                     QRLHQRHGVIVFTDPDFNGERIRRMIMTVIPTVQHAFLKRDEAVPKSKTKGRSLGIEH
                     ASYEDLKTALAQVTEQFEHESQFDISRSDLIRLGFLAGADSRKRREYLGETLRIGYSN
                     GKQLLKRLELFGVTLAEVEEAMKSYE"
     gene            complement(33033..33806)
                     /locus_tag="VVO18_000640"
     CDS             complement(33033..33806)
                     /locus_tag="VVO18_000640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TatD family hydrolase"
                     /protein_id="HEU5585842.1"
                     /translation="MIFDTHTHLNVEEFAGRETEEIALAAEMGVTQMNIVGFDKPTIE
                     HALELVDEYEQLYATIGWHPTEAGTYTEEVEAYLLDKLKHSKVVALGEIGLDYHWMTA
                     PKEVQEQVFRRQIQLSKDLDLPFVVHTRDALEDTYEIIKSEGVGPRGGIMHSFSGTLE
                     WAEKFVDLGMTISFSGVVTFKKATDLQEAAKELPLDKMLVETDAPYLAPVPKRGRENK
                     TAYTRYVVDFIADLRGMTTEELAVATTANAERIFGLDSK"
     gene            complement(34111..35004)
                     /locus_tag="VVO18_000641"
     CDS             complement(34111..35004)
                     /locus_tag="VVO18_000641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816585.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1542 domain-containing protein"
                     /protein_id="HEU5585843.1"
                     /translation="MVAQDPKAQDSTKPTAEKSTVKAPAQRVDVKDITHLTDEEKVKV
                     AILQANGSALDGATINVAGDGTATITFPDGSVVTILGKDTVQQSAKGESVTQEATPEY
                     KLETTPGGDKGGNTGSSDANANEGGGSQAGGSAHTGSQNSAQSQASKQLATEKESAKN
                     AIEKAAKNKQDEIKGAPLSDKEKAELLARVEAEKQAALKEIENAKTMEDVKEAETIGV
                     QAIAMVTVPKRPVAPNAAPKTTSAPQATAGTMQDVTYQSPAGKQLPNTGSASSAALAS
                     LGLVVATSGFALLGRKTRRRK"
     gene            complement(35283..35417)
                     /gene="rpmH"
                     /locus_tag="VVO18_000642"
     CDS             complement(35283..35417)
                     /gene="rpmH"
                     /locus_tag="VVO18_000642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L34"
                     /protein_id="HEU5585844.1"
                     /translation="MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
                     "
     gene            complement(35562..36776)
                     /locus_tag="VVO18_000643"
     CDS             complement(35562..36776)
                     /locus_tag="VVO18_000643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011836593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="HEU5585845.1"
                     /translation="MKEYNKSSKLEHVAYDIRGPVLEEAMRMRANGEKILRLNTGNPA
                     EFGFTAPDEVIHDLIMNARDSEGYSNSKGIFSARKAIMQYCQLKKFPNVDIDDIYLGN
                     GVSELIVMSMQGLLDNGDEVLVPMPDYPLWTAAVSLAGGNAVHYICDEAVEWYPDIDD
                     IKSKITSNTKAIVLINPNNPTGALYPKELLLEIIEIARQNDLIIFADEIYDRMVMDGH
                     VHTPVASLASDVFCVSMNGLSKSHRIAGFRVGWMVLSGPKTHVKGYIEGLNMLSNMRL
                     CSNVLAQQVVQTSLGGHQSVDELLLPGGRIYEQRNFIYNAIQDIPGLSAVKPKAGLYI
                     FPKIDRNMYRIDDDEQFVLDFLKQEKVLLVHGRGFNWQEPDHFRIVYLPRVDELAQIQ
                     EKMTRFLKQYRR"
     gene            complement(36932..37224)
                     /locus_tag="VVO18_000644"
                     /pseudo
     CDS             complement(36932..37224)
                     /locus_tag="VVO18_000644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014348.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            37386..37838
                     /locus_tag="VVO18_000645"
     CDS             37386..37838
                     /locus_tag="VVO18_000645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="universal stress protein"
                     /protein_id="HEU5585846.1"
                     /translation="MAQRYQNIMVAIDGSKEADLAFVKGVHSALRNDAKLTIAHVIDT
                     RALQSVSTFDAEVYEELQVDAESLMKEYEKRAKDAGVADVHIVIEMGNPKTLLARTIP
                     DAEEVDLILVGATGLNAFERLLVGSSSEYILRHAKVDLLVVREQEKTL"
     gene            complement(37873..39261)
                     /locus_tag="VVO18_000646"
     CDS             complement(37873..39261)
                     /locus_tag="VVO18_000646"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000453140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5585847.1"
                     /translation="MEVKAVFFDIDGTLVNNRKSVLKSTKDAIKIVKEQGVLVGVATG
                     RGPFFVKELMDDLDLDFAVTYNGQYIFSKDRVLFTSPISKLHLRHLISYAKKEGTEIA
                     LGTKDAMLGSKIMSFGLGSFSQRISRFVPSVLTRTVSQSFNRMVSKVVPQKEEDLLHL
                     MNQPIYQVLMLMTPEESEKAAADFEDLKLTRSNPFASDVINQGNSKLEGIRRVGKEYG
                     FDLNQVMAFGDSDNDLEMLAGVGMSVAMGNGSSSVKEAAKHITTSNQQDGIHKALEHF
                     GVLSSEKVFVSRDYHFNKVKTFHHMMDERTQEEPRAWDLEGATHRAGFKIEELVEFVR
                     AASPSEEDFGQAVSQLHQTLDKAADKVAKKTPAQQDLIGQVDALIDTLYFTYGSFVLM
                     GVDPERIFDIVHQANMGKIFPDGKAHFDPVTHKILKPDNWEEKYAPEPAIKKELQRQL
                     KAYERHKERNKS"
     gene            39327..40289
                     /locus_tag="VVO18_000647"
     CDS             39327..40289
                     /locus_tag="VVO18_000647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="asparaginase"
                     /protein_id="HEU5585848.1"
                     /translation="MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQV
                     HALDFFNLPSPHIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPH
                     MPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTH
                     TTNVNTFQTPTHGPLGLIMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELI
                     DMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQG
                     GGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG"
     gene            complement(40318..40566)
                     /locus_tag="VVO18_000648"
     CDS             complement(40318..40566)
                     /locus_tag="VVO18_000648"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585849.1"
                     /translation="MNTIERTRRLVKGCATHCFEVVDRTDEVSSKHCFEVADRTDEVS
                     SKHVFEVVDRTDEVSSKHVFEVVDRTDEVSNHTYGKAT"
     gene            complement(40630..41640)
                     /gene="ccpA"
                     /locus_tag="VVO18_000649"
     CDS             complement(40630..41640)
                     /gene="ccpA"
                     /locus_tag="VVO18_000649"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="catabolite control protein A"
                     /protein_id="HEU5585850.1"
                     /translation="MNADDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFSSLAKGIDDIAEMYKYNIVLANS
                     DEDNEKEVSVVNTLFSKQVDGIIYMGYHLTDKIRSEFSRSRTPIVLAGTVDVEHQLPS
                     VNIDYKQATIDAVSYLAKENERIAFVSGPLVDDINGKVRLVGYKETLKKAGIAYSEGL
                     VFESKYSYDDGYALAERLISSNATAAVVTGDELAAGVLNGLADKGVSVPEDFEIITSD
                     DSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREVLLPHGLTERSSTRK
                     RK"
     gene            complement(42065..42664)
                     /locus_tag="VVO18_000650"
     CDS             complement(42065..42664)
                     /locus_tag="VVO18_000650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585851.1"
                     /translation="MKVLVAEDQSMLRDAMCQLLTLQPDVESVLQAKNGQEAIQLLEK
                     ESVDIAILDVEMPVKTGLEVLEWIRSERLETKVVVVTTFKRAGYFERAVKAGVDAYVL
                     KERSVADLMQTLHTVLEGRKEYSPELMEVVMTRPNPLTEQEIAVLKGIARGLSNQEIA
                     DQLYLSNGTIRNYVTNILSKLDAGNRTEAANIAKESGWL"
     gene            complement(42666..43763)
                     /locus_tag="VVO18_000651"
     CDS             complement(42666..43763)
                     /locus_tag="VVO18_000651"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5585852.1"
                     /translation="MLERLKSIHYMFWTSLIFMLFPILPVVIGELPAWHLLVDILFVV
                     TYLGVLITKNQRLSWLFWGIMLVYVAGNTAFVAGNYIWFFFFLSNILIYHFGVRSLKS
                     LHVWTFLLAQVLVVGRLLIFQRIEVEFLVYMLVILTFVDLMTLGSVRIRLVEDLKEAQ
                     VKQNTQINLLLAENERNRIGQDLHDSLGHTFAMLSVKIDLALQLFQMQAYPQVEKELR
                     EIQQISKESMREVRTIVENLKSRTLTSELETVKKMLEIAGIEVETDNQLDTASLTQEL
                     ESMASMILLELVTNIIKHAKASKAYLKLERTEKELILTVSDDGCGFAFLKGDELHTIR
                     DRVFPFSGEVSVISQKHPTEVQVRLPYKERN"
     gene            complement(43763..44500)
                     /locus_tag="VVO18_000652"
     CDS             complement(43763..44500)
                     /locus_tag="VVO18_000652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5585853.1"
                     /translation="MKRWIALSKIEFLLTKRQLIYYLLSVGMPTAFYLFFSGIYQDTP
                     GEPANFMRDYLISMTAFSMMSTTIFSFPAVLHTDKMNNWQKTLRHSPVNMVEYYLSKI
                     TSMLVDYLVSILVVFTVGHFVRGVDMPLVKWVGAAILLIVGSIAFVALGLTLTLLPTS
                     QLMSVVGNLLYLGLAVLGGLWMPISLFPDWMQAVGKCLPTYQLMELLKTFLNEGGINL
                     SATVYLLVFSAVLFGLTIYLQGHKENA"
     gene            complement(44502..45386)
                     /locus_tag="VVO18_000653"
     CDS             complement(44502..45386)
                     /locus_tag="VVO18_000653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585854.1"
                     /translation="MTVVKVEKLSKKIKDKEILRNISFEINDGECVALIGPNGAGKTT
                     LLDCLLGDKLVTSGQVSIQGLPVTSSKLDYTRAYLPQENVIVQKLKVKELIAFFQRIY
                     PNPLSNQEIDQLLQFVKQQKEQLAEKLSGGQKRLFSFVLTLIGRPKIVFLDEPTASMD
                     TSTRQRFWEIVQELKAQGITILYSSHYIEEVEHTADRILLLNKGELIRDTTPLAMRSE
                     EIEKHFILPIAYKEVVEQSNLVENWTLKQDSLQVVTREADAFWELLAQAGCRMQEIEV
                     NNRSLLNTIFEETQKGDN"
     gene            complement(45373..45567)
                     /locus_tag="VVO18_000654"
     CDS             complement(45373..45567)
                     /locus_tag="VVO18_000654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820182.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585855.1"
                     /translation="MKRGIIYFFIGLSLLVWLVEMFTDWFDQALLRQFIRGALGFGFM
                     IFVVFLMGMEWLKGESHDGG"
     gene            complement(45564..45770)
                     /locus_tag="VVO18_000655"
     CDS             complement(45564..45770)
                     /locus_tag="VVO18_000655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503440.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585856.1"
                     /translation="MGEEEMRNKMIIAVSLVVAGVMTYLMFSGLDEDFYHFPWKVFAG
                     FGIMSWLVREGLKLVRDVKKEFEE"
BASE COUNT        13163 a        10715 c         8752 g        13442 t
ORIGIN      
        1 ggaagatatt gtgaaagtca aagatgatga taaagttgag tggaatttgt tagaatttca
       61 aaaatttaga gcatttttgg cttagtaatc tgtgttgaag gctcaaaacc tatggtaaaa
      121 aagtagcttt gaaaacgtat tgcctccaaa gatttagtta aataatgatt taacacaaaa
      181 agaaattatt gaagttctgg aaagatgttg tttcagtatt gagaaaaggt gggaaaaact
      241 tgcgattttc acagagaaag gaagaaaaag tatagaaata tagtcaattg aaacaagaac
      301 aggataaaag aaccttttgt gccatatttt tctcctttcg ctttacaatt ggattgaaca
      361 cctttattgt atcgcgtttg gagttttttt ggtataacct tcgacgcgca cccgcatagc
      421 gggtgttttt ttgtctcgca cctaacggag cgagacaaac taatagtcac ttaatcaaaa
      481 aacgcaccat atcaaaaact aaaaagtttg atatcatgcg tcatgtctta aactaattga
      541 ctatactttc tattcaaatg agcttttaac caattgattg agccaatcca ctcttaaaac
      601 caaagagcaa tttctcgctt agctgactct tctgaatctg aaccatgtac aacattttgg
      661 ataatctcat tttctccagc agcttttgca aaatcacctc gaatagtgcc tggtaaagct
      721 tcttctggac gagttgcacc catcatggtc cgccaagttt cgattacttt gggaccagaa
      781 atgacaccca caagaactgg acctgaagtc atgaattcac gaatcggtgg gtaaaaactc
      841 tgaccaacca agtcctgata gtgctggtca atcaactctt ctgaaacctg tgaacgaaac
      901 tccaattttt cgattgtaaa tccacgttgt tcgatgcgct ttaacacttc acccactagc
      961 cctcttttta caccatctgg tttgatgata aagaatgttt gttccatacc cgtctccttt
     1021 gtcagcttct ttcttttatt ttaccacatt tcgtggaaaa atggagaaag ttttcagaag
     1081 agagaatgag agaacccgag ggttctctca ttctctctta ttctactgtt tcttccacag
     1141 tttcaacggc agtatccaca actacttctg ttgtttcttc atttccttct tcctctactg
     1201 gaggattaag gtattcttct tcgttgacag catgtggttc aaggttacgg taacgggcca
     1261 taccagtacc agctgggatg atcttaccga tgataacatt ttctttaagt ccaaggagat
     1321 ggtctttctt accacggata gctgcgtcag taaggacacg agttgtttcc tggaaggaag
     1381 ccgctgacaa gaaactgttt gtttcaagtg aggctttggt aattcccata aggactgggc
     1441 gacctgtcgc tggaactcca cctgcgataa ggacatcttt gttggcatct gtaaagtcat
     1501 tgatatccat gagggtaccc atgagaagat ctgtatcacc tggatccatg acacggactt
     1561 tacggatcat ttgacgaacc attacctcga tgtgtttgtc accgatttct accccttggc
     1621 tacggtaaac tttttgtact tcaccgagaa ggtacgtttc aactgacaag acatcacgaa
     1681 ctgcaaggag acgttttggt tggatagaac cttctgtcag agcagcacca cgcgctactt
     1741 ggcccccaac ttcgacacgc atacgagctg taaatggaac gacatattca ccttcgccag
     1801 tttcaccctt aacaaagact ttcttggtac gagttgatgc atcttcttcg atagcagtaa
     1861 cttgtccttt aacctctgtt ataaccgctt cccctttagg attgcgggct tcaaagattt
     1921 cttggacacg aggaagaccc tgagtgatat cggtatttga ggcaacccca cctgtgtgga
     1981 aggtacgcat tgtaagctgt gtaccaggtt ccccgataga ttgggcagcg attgtaccaa
     2041 ctgcttcacc aacttcaacc gcatcaccag tcgccaagtt gataccataa cagtgacggc
     2101 agacaccgtg acgagtgtta catgtaaata cagaacggat agtcacttct tccacaccag
     2161 cattgacaat ttcacgcgcc ttgtcttctg taatcaattc atttggacca ataatcactg
     2221 caccagtttc tggatgttta acagttttct tagtgtaacg accgttgaga cgctcttcga
     2281 gagactcgat catctctttt ccttctgcga tagaacggat caagagacca cggtcagttc
     2341 cacagtcgtc ctcacggatg ataacgtctt gggcaacgtc gaccaaacga cgagtcaagt
     2401 aacctgagtc ggctgtctta agggccgtat cggtcatacc tttacgagca ccgtgagttg
     2461 agaagaacat ttccaatacc gacaaacctt cgcggaagtt tgaaagaatt ggcaattcca
     2521 tgatacgtcc attcggagca gccatcagac cacgcatacc ggcaagctgt gagaagtttg
     2581 agatgttacc acgggctcca gagtccatca tcataacgat tgggttctta ggatcttggt
     2641 tagcaatcaa gcgtttctca agtttttcac gggcagcacg ccattcagct gtaacagcat
     2701 tgtaacgctc gtcgtctgtg atcataccac gacggaattg tttggtgatt tgttcgacac
     2761 gtttgtgtga ttcttcaatg atttcagcct tgtcatcaac gactgggatg tcggcaatac
     2821 ccactgtcaa tcctgcaaga gttgagtggt ggtaaccgag attcttcatg cggtcaagta
     2881 gggcagaagt ttctgtcgta cggaaacgtt tgaagatttc agcgatgata tttccaaggt
     2941 tttttttctt gaatggaggg ttgagctcaa gattgctgat agcttccttg atatctccac
     3001 caagtggcaa gaagtattta gctggaacac cttctgtcaa gttggcattg tttggttctt
     3061 gcaagtatgg tagcccctct ggcatgatat cgttgaagag aattttacca actgttgtaa
     3121 gcaagacctt atgtctttgc tcttctgtcc aaggcttgtt gaggctgtct gttgcgatac
     3181 caacacgtga gtggaggtga acatagccat tgcggtaagc cataaccgct tcgtcacggt
     3241 ctttgaagac cattccttca ccttcgcgac cagcttcttc catggtcaag tagtagttac
     3301 ccaaaaccat gtcctgagat ggagtaacta ccggtttccc atctttcggg ttcaagatgt
     3361 gctcagcagc tagcatgagg atacgagctt ctgcttgtgc ttcttctgaa agtggtacgt
     3421 ggatggccat ttggtccccg tcaaagtcag cattgtaggc ttcacagaca agtgggtgca
     3481 agcgaagagc cttaccatca atcaagactg gctcgaaggc ttggataccc aaacggtgaa
     3541 gggtcggtgc gcggttcaaa agcactgggt gttctttaat cacttcttca aggatatccc
     3601 agatacgctc atctccgcgt tccaccaagc gtttagctgc tttgacgttt tgcacgatat
     3661 cacgggcaac gatttcacgc atgacaaatg gtttaaagag ttcaatcgcc atttcacgtg
     3721 gcacaccaca ttggtacatc ttaagagttg gaccaacagc gataacggaa cgtcctgaaa
     3781 agtcaacacg tttaccgagc aagttttgac ggaagcgtcc ttgtttacct ttaagcatgt
     3841 ggctcaatga tttcaatgga cggctacctg gtcctgtgat tggacgacca cggcgaccat
     3901 tgtcaatcaa agcgtcaact gcttcttgaa gcatacgctt ctcattttga acgatgatac
     3961 ctggtgcatt taactcaagc aaacgagcca aacggttgtt acggttgata acacggcggt
     4021 aaaggtcatt caagtcagat gaggcaaaac ggccaccatc caactgcaac attggacgaa
     4081 gatctggtgg aataaccgga aggatgttaa gaatcatcca ttcaggtttg tttccagact
     4141 tgtaaaaggc atccaaaaca tccaaacgac ggatggcttt gacacgtttt tgtccagtag
     4201 ctgttttcaa ttcttctttg agttcagcaa tttctttttc aagatctact tgcttcaaaa
     4261 ggtcttggat ggcttccgca cccatcttgg caacaaatga accataacca tattcacgca
     4321 agcgctctcg gtattcgcgc tctgtcatga tagacttgtg ctcaagtggt gtatccttag
     4381 gatcaatcac cacataagcc gcaaagtaga taacttcctc gagggcacga gggctcatat
     4441 caagggtcaa gcccatacgg cttggaatcc ccttgaagta ccagatgtga gatacaggag
     4501 ctttcaattc gatatgtccc atacgctcac gacgaacttt cgtacgcgtt acttcaaccc
     4561 cacagcggtc acaaacaatt cctctgtaac gaatgcgttt gtacttacca caagcacatt
     4621 cccagtcttt tgtaggacca aagatcactt catcaaagag tccttcacgt tctggtttca
     4681 aggtacggta attgattgtt tcaggttttt tgacttctcc ataagaccat gaacggactt
     4741 tacttggaga agctagggtg atttgcatac ttttaaaacg atttacatca accactattt
     4801 cttccctttc tattctaagt gaactgctta ttcttgttca gcagcttctt ctgttgcttc
     4861 cgcttttgtt gctttctcag cttcttcagc ttcaaaggct gctttagcct cttgggctgc
     4921 tttttcgcgg gctttttcaa ggtcatctac gtggatgaca tcttcgtcca ttccttcatc
     4981 caagtcgcga agttccactt cttggtcatc ttcgtctagg acacgcatgt caagaccaag
     5041 agattgcaat tctttgacaa gaactcggaa ggattctgga acacctggtt ttggaattgg
     5101 tttgcctttt gtaatagctt cataggcttt caaacgtccg ttgatatcgt cagacttgta
     5161 agtcaagatt tcttgaagga catttgacgc accgtaggct tcaagagccc aaacctccat
     5221 ctcaccgaaa cgttgtccac caaactgagc tttacctccg agtggttgtt gggtaacagt
     5281 tgagtaaggt ccgactgaac gcgcgtgcaa tttatcgtca accatgtggt ggagtttgat
     5341 catgtacatg actccaacag aaacacggtt atcaaatggt tcaccagtac gtccatcgta
     5401 aaggatcgtt ttggcatcgc tatccatacc tgcttcttta acagttgacc aaagatcttc
     5461 agaacttgct ccatcaaaga ctggtgtcgc aatgtgaata ccaagagtac gagctgccat
     5521 accaaggtga agctccataa cctgaccgat attcatacgt gatggcaccc caagtgggtt
     5581 caacatgatg tcgactggag ttccgtctgg aaggtaaggc atgtcttcta caggaacgat
     5641 acgagagaca acccctttgt ttccgtgacg tccggccatt ttatctccga ccttaatctt
     5701 acgtttttga gcgatgtaaa cacgaaccaa catgttaaca cctgattgca actcatctcc
     5761 atttacacgt gtaaagatct taacatcacg aacgacacca tcggcaccgt gtggtacacg
     5821 aagagaagta tcacgcactt cacgagactt gtctccaaag atagcgtgca agagacgttc
     5881 ttcagctgaa agatctttct cacccttagg tgttacttta cctacaagaa tatcaccttc
     5941 tttaacctca gcaccaatac ggataatccc catttcgtca aggtctttga gggcatcttc
     6001 accaacgttt ggaatttcgc gagtgatttc ttcaggccca agctttgtat cgcgcgtttc
     6061 tgattcgtat tcttcaaggt gaacagatgt gtagacatcg tccttcacca agcgttcgct
     6121 catgataacg gcatcctcga agttgtaacc ttcccaagtc atgtaggcaa cgattgggtt
     6181 ttgtccaagc gccatttctc cattttccat agaaggtccg tcagcgatga aatcgccttt
     6241 ttcaacgaca tcaccaactt ttacgagagt gcgttggttg taagcagtac ctgagtttga
     6301 acgacggaat ttttggatgt ggtaaacatc caatgatcca tcttcacgac gaacttctac
     6361 cttgtcagca tctgcgtaag taactttacc atcatactga gcaatcacag ccgcaccaga
     6421 atcgtgggct gcttggtatt ccataccagt accaacgtaa ggtgcctgag gattaatcaa
     6481 tggcacagcc tgacgttgca tattggctcc catgagggca cggttggagt catcgttttc
     6541 caagaaagga atacatgctg tcgcaacggc aactacctgt tttggtgaaa cgtccatgta
     6601 gtcaacaata ttagctggat actcttggtt gaccccttgg tgacgtccca tgacaatctt
     6661 ctcagcaaag gttccatctt cattcagacg agagttagcc tgagctacag tatattcatc
     6721 ttcttcatca gctgtcaacc aaacaatttc gttcgtgaca acacctgttt cacggtcaac
     6781 cttacggtat ggtgtttgaa caaaaccata tttgttcaag tgtccgtaag atgacaagtt
     6841 attgatcaaa ccgatgttag gtccttcagg tgtctcgatt ggacacatac gaccatagtg
     6901 agtgtagtgc acgtcacgta cttcatatcc agcacggtca cgagtcaaac caccaggtcc
     6961 taaggctgac aaacggcgtt tgtgagacaa ctcagaaagc gggttgtgtt ggtccatgaa
     7021 ctgtgacaac tgtgatgaac caaagaattc tttaactgca gctgttacag gacggatatt
     7081 gataatttgt tgtggtgtca agacttcatt gtcctgaaca gacatacgtt cacggacatt
     7141 acgttccata cgagaaagtc ccaaacgtac ttggttggca agcaattcac caaccgcacg
     7201 gatacgacga tttccaaggt ggtcgatatc atctacacgg ccaagtcctt cagccaagtt
     7261 gaggaagtag ctcatctcag caaggatatc tgcaggagtc accgtacgaa ccttgtcatc
     7321 tgggttagca ttaccaatga tcgttacgac gcgatctgga tcagttggag caacaacctt
     7381 gaatttttga agaacaacag gctcagtcac aacggctgca tcgtttggga tgtagacaat
     7441 cttgttcaag tcgccatcca aatggctttc aatgctttca atcacgctac gagtcataat
     7501 cgtaccagct tctaccaaga tttctccagt ttcagggtct accaatggct ctgcaatggt
     7561 ttggttgagc aaacgtgttt taacattgag ttttttattg attttgtaac gaccaactgc
     7621 tgccaagtca tagcgacgtg ggtcaaagaa gcgagccaca agcaagctac gtgagctttc
     7681 agctgtctta ggctcacctg gacgaaggcg ttcgtaaatt tctttcaagg cttcgtctgt
     7741 acgagagtcc attggatttt tgtggatatc tttttcaaca gtgttgcgaa ccaattcgct
     7801 gtcaccaaag atatcaaaga tttcatcatc acctgagaaa ccaagagcac gaaccaaggt
     7861 tgtaaatgga atcttacgag tacggtcgat acgagtgtag gtgatatctt ttgagtcgct
     7921 ttcaagttcc aaccaagctc cacggttagg gataacagtt gaaccatagc ccaccttacc
     7981 atttttgtct actttgtcgt taaagtaaac acctggtgag cggaccaact gagaaacgat
     8041 aatacgttca ccaccattga tgatgaaagt acccatttct gtcatgattg ggaaatcacc
     8101 aaagaaaact tcttgggtct tgatttcgcc tgtttcttta ttgatcaaac ggaaggttac
     8161 aaaaattggt gctgagtagc tagcatcgtg gatacgagct tcttctagcg tgtattttgg
     8221 ttccttgatt tcatatccaa caaattccaa ctccattgtg tctgtgaagt ttgaaattgg
     8281 caatacatct tcaaacactt ccttaagacc gtggtctagg aaagctttga atgagtcagt
     8341 ttgaatttca atcaaatttg gtaagtcaag aacttctttg attcttgaaa aactacgacg
     8401 ggtacgatgt ttcccgtatt gaacgtcatg tcctgccaag atgattctcc tttgtaaata
     8461 agttccaagc cttgtcaatc aggcttttct aatcgtcata tggttgtaaa ccccttatca
     8521 ccgtgtcctt ttgacgaatt ttcagaatct ttaagcctct gttacaaatg ctcaaaatct
     8581 tgaaaaaaag cacaaaaaga gcagctaaat ctgacttttt cagaagattt aactgctgtg
     8641 agccttgtct ggacaatatt tcagacaaaa cctacgacaa atgattaccc atattatacc
     8701 ctatttagct agatttttca aggggtttca gtaggttttt ggtaaatttt ttcccataga
     8761 aaacttggca tcacattcga atcacgctat ggtacaaaaa actgaaaaaa ctattgactg
     8821 aaaatcattt tcaaggtata ataataaacg ttaaggcggt atagccaagt ggtaaggcac
     8881 ggctctgcaa aagcttgatc gtcggttcaa atccgtctac cgccttctat aacttgattt
     8941 atcaggtttc aaatgaacag aaagcccaat ttgaagggct tttcttattt tccctcgaat
     9001 aaatacgtat aactttaaaa acttttggag cgagtttgtg gcagagttct ttccatggca
     9061 taattccctt ttgaaatcaa ttgaaaaaag cttcgtcacg cctggtgaca aaagcctcta
     9121 gtttattctg tttcttcttc tatttcgact tctgtgattt ggacttttac cttggtaaca
     9181 cgtccattct tcactttatc attggttaag ataaactgtt tgttttggct gaccaattca
     9241 tagctgagtt tctcagtcgt tggaatagtt cccactcctg tcaaataata accagcgatg
     9301 gtatcaacgt catcactttc cagttcaaca tcaaagtaat tattgaaatc attgagggtc
     9361 atagttcctt gaacaatgta ggtatcctcg ccaatctgat gaacatctat tgctgctttg
     9421 tccgtttcat catcaatttc accaacaatt tcctctaaga ggtcttccaa agtcaccaaa
     9481 ccagccatac caccgtattc atccagcaag attgccattt gtctttgggt atttcgcagt
     9541 tcttttagca agtcatccac aaaaatagtt tcaggtacaa aaagtggatc ttgtaaaatt
     9601 ctcttccaaa caatattgtc aaaaccgtcc acaaagcctg ccttaaggag actcttggtg
     9661 tgaatgattc caattacatt gtccttatcc ccatcataaa ccgggatacg agaataattt
     9721 tgttttaaaa tactttggat aatggcttga ctatcatcct gaatatccac cataaaggca
     9781 tccgttcgag gcaccataac ctctcgtgcc atcagttcat cgagcgaaaa gacaccttgt
     9841 agcatctcaa tctcatcagc atccaatgtt tcttcactat ttgtcagcat ataggcaatt
     9901 tcatcacggg tcatcttttc atccgcatca tcgaatgaca taggagtcaa atggctcaag
     9961 aaattggtcg aagcagctaa aagccaaaca aaaggactga ctagttttcc gatcccaatg
    10021 ataatcggcg ctgtacgaat tgccaaggca tcctttagat taagagcgat tctcttagga
    10081 tataattccc caaaaacgat ggaaatatag gtcaaaaatg ccaaggatag aaaagttgcc
    10141 acggcttgtg ctgtttcgcc attcccaagc caagaggcaa tcacacgtcc tagagtatca
    10201 gttaaactcg cccctgataa gattgtaatc agggtgattc ctacctgaat ggttgataaa
    10261 aagtggttag gattttctag taccttcagc aggcggatgt agcgtctgtc tccttcttcc
    10321 gccttttgtt caactcgggc acgattaaga gaaaccatgg ccatttctgt ggctgagaaa
    10381 aaggcattta ataccgtcaa gataaacaat aaaacaaatt gtagcaacaa attctgacta
    10441 cttgggtctt ccatagttct tctcctaaaa tagtatctta tcctttatta tatcacaaaa
    10501 tttaatccaa tacatattat ttttttctta gcgtaacttc catctctctc ccaaaactgg
    10561 aagttagtct aagacggatt tccactgatt tcacgcgttt ttctcatact aaaagctagg
    10621 ttgtgggaaa ctggaagtta gttttagaag ttactatttt ttcttagtac ctattctagc
    10681 cctgcttaaa ctagtaaaaa gaactcctac atccataagt gacataggag tttaggctta
    10741 tcttttactg agttacagtt acttctccag ttcggtaatc cagttgaagt cccttttgaa
    10801 cattgggaac tagaacattg aattccaatt ctccatccga agacttggct tcaatctgtg
    10861 aagctgaggg aactaaatcc tcgtttgaag cgtagtaaag ggttacacgg taacggacac
    10921 gcttgttttg gtccaaggct ttacgcacct tgctttcata gtagttttga ccagtcgaat
    10981 actcggcttg tgcctgattt gcccaggctg tctgaacagc aatgttttta ggattgcttg
    11041 ttgaggcatc aaaaccatcc aaaccaccga ttaaggcata gcctaacaaa tgacctctat
    11101 cgactgcatg ggtataagag ccctttagat tcttgacctg atgccaacct ggaggagtcc
    11161 aagaagttga accattccca gtttctttac gattcttgta ctgacgagtg gcattagaca
    11221 agagggcatt agctacggtt ggaacagttt ccttgcccac tgtctttgtt ttattgtcag
    11281 cgtagggctt acttgaaacc ttggcatcta gatttgtttt attaccattg acgataaaag
    11341 cacctgagcc attccactcc agactcccct ttatttgact cttgactgcg tctgttaaga
    11401 cactctctgc caatgcttga ctaggagctt caggcgcttg ttttttctga ctaagattgg
    11461 ttttgggact attaggtgcc gactgcatct gcttgatata atagctccct gtagacaaaa
    11521 gcaataacac tagcagtccg attagtgtct gtcttgtttt tttgttcata tttctcctta
    11581 tctttagaaa aaggctggtt ctccagccta atttcctgta aatttatgaa tcaattcctg
    11641 ccattttgct ggagacagga tagcccatgg atcttgaccc ttgcccaaga ttccataacc
    11701 taccattaga ccgattccta gagccagagt acctaaaatc agtactatga tgactaaaag
    11761 taaacgcttg actacgtagc ttgatttctt attcatcttc atcacttgcc tcaatccgct
    11821 gaatcttagc acctagctga gccaacttct catggaaacc gtagtaacct ctatccaagt
    11881 gaaccaattt accgaccaca gtttctccct gtgctaccaa acctgtcaaa atcaaggctg
    11941 cactggcacg aaggtcagtt gaaagaactt ctgctccctg caaaggctgt ccaccaacaa
    12001 tacgagctgt atcacggata atctcagaat gcaagcccat gcggcgcatc tcttctaggt
    12061 gttggaaacg attttcgaaa actgtctcca ccatggttga ttcgcctttt gcaactgtca
    12121 tcaaggctgt aaattgagcc tgcatatctg ttggaaatcc tgggtggggc aaggttttca
    12181 catgaacagc ttttagattt tctagttgag aacgaacacg aattccttcg tcttcttcaa
    12241 ttacttcaac acccatttca agtaacttgg caatcaaggg acggttgtgc tcccagacag
    12301 cgtctcgaat caagacatca ccaccagtca tggcagcagc taccataaag gttcctgctt
    12361 cgatacggtc ctggactaca ttgtgagtcg taccatgaag tttctcaaca ccagtaatgg
    12421 ttatagtctc tgtaccagca cctttgacct tggctcccat ttcattaagg agaatggcta
    12481 agtcaacaat ctcaggctca cgcgcagcat tctcaatcac tgtcacccca tcagccagag
    12541 tcgctgccat catcaagttc tgcgttgcac caacacttgg aaagtccata tagatatgag
    12601 caccatgcaa gcgttctgcc tttgcttcga tgtaaccagc tgtctgacta atcttaaccc
    12661 ccatagcttc cagacctttc aaatgaagat caataggacg gctaccaatc gtacaaccac
    12721 ctggcatgga taccttggca tgacccacac gggcaaggat tggccctaat acaacgatgg
    12781 aggcgcgcat cttactgaca tacttgtaag gggcttcctc agtgatgtcg ccagtagcat
    12841 ccaccttgac aagatgagct tcctcatcaa agtcaacctt ggcattcaaa ccaccaacta
    12901 cctgattcat aataaagaca tccgacaaaa tcggaacatt ctgcaagacg gtctttcctt
    12961 cacttgctag aatagtcgct gccaacaagg gtaagactgc attttttgct ccctcgatcg
    13021 tcacgcttcc taccagacga ttatcgccac cttgaaccac aattttatcc atactcgttt
    13081 cctttactct tgattttata ataatcctct aagcgcttct tgccacaaat gatacaggct
    13141 aataaagaaa gaactcagga tgtagcctat gacaatgcta aaaaaggcta ctaatacacg
    13201 aacttttctt gtattctcag ctgtcacttt taaaaccttt tcccatctaa caagatcctt
    13261 taaaaggtaa aaactcacat aaataaagag catatgacta cttagagtga ataataattg
    13321 aaccatttga ctattatacc atcttctctg tttgtgcgct agtttggaaa cttcactcaa
    13381 aaattaggga ttgtttttca agtaatcaat cgcatcttgt agggttttaa cgggcacgat
    13441 tttcatatcc gtcttgattg ttttagccgc ttctagggct gtttggtagt tgtttttcgc
    13501 gtccggatgc gccttttgtt cttcttcgct aacagggtta tcaggagcaa agaaaatagc
    13561 agcacctgcc ctagccgaag ctacaacctt cttatcaata cctccaatgt ctcccacatt
    13621 accatcgcgg tcaatggtac ctgtaccggc aacaatacga ccattacgaa gatctgggtg
    13681 agctatttga gtatagatag ctagactaaa catgagacca gcacttggtc cgccaatacc
    13741 agctgttgaa aagctaattg ggacattgct gattacctct gtacgatcaa tcaagccgat
    13801 tccaatccca ttttttccat tttccaaggt gataatcttt ccttctgcag acttggtttg
    13861 cccatcctct tcataggtga ccttgacgga gtcccctaat ttttgagaac tgacgtaatc
    13921 aatcaagtct ttggaactat caaaggtctg atcattgact gctgtgactg tatcagagat
    13981 attgagaatc cctttaaagg ttgaattatc cgtcacattc aaaacataaa ctccaaagta
    14041 cttgagttcg atatccttac cagctgtttt tagtccttga tacttggcca tattttgcga
    14101 tgtttgcatg tagaattgat tgattcgcat aaattcaaca tcggaagaac cacctgtagt
    14161 ctcctgagca ctacgaatat ctgtaaaagg tgtcaaccaa gcataaatca tatgagctaa
    14221 agtagcatgt tgaacaccaa ccgtaacgaa ttgataggca ccagcttcct tatcttctgt
    14281 gtcatttact ttaaggactt ggcgaatatc ttccgaacca cctggaacct ctatatagta
    14341 gggcaaaggc accacaaatg ccaagaaggt cacaatcaag gccgcaatga catacaaggg
    14401 ccatctaatc ttttttttca tttcttattt cctccaaaat actctcggga acatggcagg
    14461 caatatcctg accaaacttc aaaagctctc gaacacctga tgaactgata tagagatgtt
    14521 caggccggct atgtaaataa atagtctcta tatcagaaga cagctgatga ttgtagtaat
    14581 caaaactagc ttcatattgc aaatccgccg cattcctcaa cccccgtact aggaaagtag
    14641 cccccagtct ttttgcaaca tcgaccacca atttatcatg agaagccacg acttcaacat
    14701 tttccaaatg tcccaaagcc ttttctagcc cccgtttacg attttcaaga gggagaaatc
    14761 cttgtttgtg gggattaaaa aaaataccca cataaagctt atcaaaaagt ctgctcgccc
    14821 gttcaatgat atccagatgc ccatttgtca tcggatcaaa tgagcctgtg aataagccaa
    14881 tcttatctga catagactgt caccttacta attccataaa tcttttcctt ccagataccc
    14941 agacaggcaa tttcttctgg aagttcaacg gctttatccg tctcgcacac aaccataaca
    15001 tcttcagaaa aaagctctct ctcagccatt ttttcaatat ctgctacgat ttgttccttg
    15061 gcatagggag ggtctaagaa aacgaggtca aattccccag atacctgttc caatgccctt
    15121 tctgcatcca ttttgaggag ttgaaatttt ccaacttcct tggtcatctg gatattttca
    15181 gccacgatgg tctgagcctt acggtctcgc tccaccaaaa cagcactgga catgccacgc
    15241 gatactgctt cgatagataa accaccacta cctgcataaa ggtccaagac tcgtccccct
    15301 tcaaagtagg gaccaatcat gttaaaaatg gctcccctaa ccttatccga agtaggtctt
    15361 gttgtcttgc cttctagtgt cttaagggga cgtcccccat agattcctga tatgattttc
    15421 atactgttta ttataccaaa ttatagacaa aaagagaaag aaaaccgaac cttgcggttc
    15481 gattctctac aaaatatttt cgtaagtatc gcggacttct tgaggccaaa cacttgtttg
    15541 cacttctccg atgtgtctct tgcgaagtag gaacatggcc atacgagatt gtccaattcc
    15601 tccaccgatt gtcaatggga ataggccatt caacaaagac ttgtgccatt ccaattccaa
    15661 gcggtcttca tcacctgtaa tttccacctg acgtctaaga gtttcttcat ctacacgaat
    15721 tcccatagaa gacaactcaa aggctccacc taaagactca ttccagacaa gaatatcacc
    15781 atttagaccc ttgtagccat tctcagactc gcttgtccag tcatcatagt ctggtgcacg
    15841 tccatcgtgc ggtttaccat ctggcaactc gccaccgata ccaatcaaaa agacggctcc
    15901 aaattcttta caaatcgcat tttcacgttc tttcggtgtc aagtctgggt agcgttctac
    15961 caattcttct gtatggataa aggtgatttg ttttggcaag atagactcga tgtcatagcg
    16021 ggcttcaaca gctagctcag tcaggcgaat agccttataa atcttctcaa ctgtttcttt
    16081 tagataaacg atgttacgct taccatttgg gataaccttc tcccagtccc actggtcaac
    16141 ataaacagag tgggttgcat ccaaggaatc ctcatctgga cgaagggctt tcatgtggac
    16201 aaagagaccc tctccttcac caaagccaaa acgagccaag gtgtggcgtt tccatttagc
    16261 aagtgagtgc accacttcat aagtagcatc agggatttgg agaaccttga ccgatactgg
    16321 attttccaca ccagacaggt tgtcctgcat tccgtcaccg accttactca agataggacc
    16381 ttgaacttcg acaacttcta gcttatcttt caaatactgg gtaaaagtgt ttttgacaaa
    16441 ggaaatttct tcttgttgat ggataaaact tttcttcata gacaactcct caaaaattta
    16501 ataaacgtat tatacaccta tttccaagaa aagaaaagag aaaatttaaa aaaatcagtg
    16561 tcactcaaaa cactgatttc atagaccttt tagtcattgc gaccaaagat acgtagaata
    16621 cttaggaaaa gattgataaa atcaagatag atgctgagag ccattgacac cacccagcct
    16681 gtcgctacac gaccttgtga ttgttcatag gcgaggcgaa tcttttggtt atcccaagca
    16741 atcaaccctg aaaaaaccaa aaccatggct acgctaatca tataatcaaa gaagccacta
    16801 gccaagaaaa tattgactac catagcaatc agtaaaccaa tgagagctgc catcattgct
    16861 cgaccaatcc cactcaagtc tttcttggta aagataccaa ctgccgccat gacaaagaag
    16921 agaagggcgc tcgatacaaa ggcagataaa actgtacccg gagtatagaa agccaccaca
    16981 aaactaaggg taaagccgtt taaaacggag taaagtaaaa atactggaag agcagctgga
    17041 ctatttcttg aagccatgct actggcaacg aaaaccaaag ccaactccgc aaaagtagca
    17101 atggtcaacc agagacgccc ctgcatcaac aagtaaacca actgagactg aaagaccgtc
    17161 aacataaggc ctgataccaa agcagatagt ccgattccca gaccaacaaa ggcataaacc
    17221 ttagcgtaaa attgattgag acctgcacgg tcatgtataa tagtgtgatt catccttttc
    17281 tccttttctg tgaacatctt tccttgatta taacaaaaaa agttaaaatt agcttaaatg
    17341 gaagattaaa ataccggctg caactgcaac attcaaactc tcggcctgcc ccttcatgct
    17401 aatatggacc aactggtctg cactttcagc cataagggga ctaattcctt gaccctcatt
    17461 tcccataact agtacaaaat tttctataga aggcagttct ctgtaatcaa cagaatcttt
    17521 agatagggtt gttgctagca ctgggatagc taccttttta gtttcgtcaa gaagcgcttg
    17581 actagtcatc cggtaaatgg gcagatggaa atgactacct tgcatggaac gtagggtttt
    17641 gagactgtag atgtctgccg acttatctga aacaatcact cctgtaaaac ctgctgcatc
    17701 cgcagttcga atgatagttc ctacattacc aggatcttgc acatcttcca aaaacaagaa
    17761 cttgccctga ctcaaatcag cttgtcctac ttcttctttt tgaaccaccg ccacaattcc
    17821 ctgtggagtc tgagaatccg ccaaatctag caaaatatcc tctgaaatcc agacagtttg
    17881 cggaaaagca gctaactgat ctcgataatt ttctagggca aagattttct caatcgtcac
    17941 tccagcttgg acagcctctt caaacaagtg ccagccttca atcaaatagg cagacttgcg
    18001 gtattttttt tggtgtaatt tcttggcatt ttttaccaca gaattggctt ttgaggttat
    18061 aatagtcata gaaatattat aacacaatca aaggggtttg gtatgcaaaa ggttagaatg
    18121 attgcccaag gtagggtaca gggagtcggc tttcgttggg gtgtttacag cttggcactt
    18181 gaaattggtg gcatcacagg tcgagtatgg aataacgacg atggcacagt ggaaatctta
    18241 gcccaagcag actcatctgc tatcatggca aaatttatcc aagaaatccg aaaaggaccg
    18301 acaccttttt caaaagtaag ctacttagat gtcaaactaa gcaactttcc tccctactct
    18361 gactttaaaa tcgcaaatta ggtctccaga actattgtat attttgtaaa aaaacagtag
    18421 aatagaaagg tataattttt aaagaaggaa taaaaacagt gaaatctatt aaacgttttg
    18481 cattctcggc tatgggagtg gctatgttgc ttgtcttgac tggctgtgtc aatgtcgata
    18541 aaaccacagg tcagccaaca ggatttattt ggaataccat cggagcgcct atggctgaag
    18601 ccatcaagta cttcgctact gataaaggtc taggctttgg tgtcgctatc attatcgtaa
    18661 ccattatcgt acgcttgatt atcttaccac ttggtatcta ccaatcatgg aaggcaacgc
    18721 ttcactctga aaagatgaac gctctcaagc atgtccttga gccacaccaa acacgtctca
    18781 aagaagcaac tactcaagaa gaaaaactcg aagcccaaca agccctcttt gccgctcaaa
    18841 aagagcacgg catcagcatg tttggtggtg taggatgttt ccctatcctc cttcaaatgc
    18901 ctttcttctc tgctatctac tttgctgccc aacatactga aggggttgct caagcaagct
    18961 acctaggcat tcctctaggt tctccaagta tgattttggt cgcctgtgct ggtgtccttt
    19021 actatcttca atcgctcctt tcacttcacg gagtagaaga tgaaatgcaa agagaacaaa
    19081 tcaagaaaat gatttacatg agcccactca tgatcgtcgt cttctccctc ttctcaccag
    19141 ctagtgtcac actttactgg gttgtcggtg gtttcatgat gattctccaa cagtttatcg
    19201 tcaactatat cgttcgtcca aaacttcgca aaaaagtccg tgaagaacta gccaagaacc
    19261 caccaaaagc aagtgctttc tctaaaccaa gtggacgaaa agacgttacc cctgaacaac
    19321 caactgctat cacaagcaag aaaaaacaca aaaatcgcaa cgctggaaaa caacgttcga
    19381 gataagaaga aaaaggctta gctgatttgc taagtctttt tgcaaatcaa aagcccgatg
    19441 tttccatcag gcttcttttc tatccatgta cacgtttcat ataatcttga taactttcgg
    19501 tatccatgag ttttttagcg ttcttgacgc gatctgctgt tggtggtttg actccttcga
    19561 gggaatatgg aattccaagt tcacgccact tgaactcacc catggtgtga taaggtagaa
    19621 tttcaaactt atcaacattt ttgagggtct tgacgaactt accaagttca atcaagtcat
    19681 catctctgtc tgtcaatcct ggaactagca cgtggcgaat ccagacaggt tttccaatat
    19741 ctgatagata ctgggcacaa gccaagatat ttttattggt ttggctagtg acaatcttgt
    19801 gctgttcttc gttgatttcc ttgatatcca aaagaaccaa gtcagtgaca gccatgagtt
    19861 tgtcaaactt ctcaaggtaa cgtggtttat tacggaaagg aagagcacag gtgtccaagg
    19921 tacaatggat tccttgttcc ttagccttgg tgaagagagc aatcaggaaa tcaatctgca
    19981 agagagcttc tcctccactg actgtaatcc cacccttatt tccccagaaa ccacggtagc
    20041 gcaaggcctc tgtcaagaca tcatctaccg tccgttcacg tgacttattg gactccatag
    20101 cccaagtgtc tgggttgtgg caatactggc aacgcatgtg acagccctgc aaaaagacaa
    20161 taaagcgaat accaggccca tctactgacc caaagctttc tgtcgaatgc accatccctg
    20221 tcacttgtcc ataatcaatt gtttcttcag acatatcgtt accttccttg aaaacgtttt
    20281 atagttttat tatatcacga cttgaaggaa aaacaagatt tttgcctatt ttttagaaag
    20341 caatctgttt ttcaatttca ttttcaatct atcatcagat tattcttcaa aatcaaagcc
    20401 atataaggtt gcaaaatagt cctcggggcg ctctgcacgg cggatttgac gggctttacc
    20461 ttcttcggta tagaggattt ccgcagaacg taatttggca ttatactggt agcccattga
    20521 aaatccgtgg gcacctgtat catgaattac cagcaaatca ccgatttctg tatgaggcag
    20581 ttcgcgattg actgcaaatt tatcattgtt ttcacagagt gaaccaacca catctaccgc
    20641 ttcagctggt ccatctggat gggtcacgtt gctaatatga tggtaagccc cgtacatagc
    20701 tggacgcatg aggttgactg ctgaggcatc cacacctaga taggtacggt aggtttcctt
    20761 cttatgagtc actcttgtga ctagagcacc gtgaggtgcc agcataaaac gacccaattc
    20821 ggtgaaaatc ttgacctgac caagacctgc tgacgtaaga acttcttcat acaccttacg
    20881 aactccctca ccaatcaagg cgatatcgtt cggctcctgg tctggacgat aattaacacc
    20941 aataccgcca gaaagattga taaagtctaa cgaaatgccc aacttttcct tgatttcaac
    21001 agccagttca aagagctgac gagccaactc tggataatag agatgggtca cggtattgga
    21061 cgctaggaag gagtgaagcc caaaagtctt ggctcctttt tccttcaaga tagcaaaggc
    21121 ttcaaagagc tggtccttgg tcatgccaaa cttagcctcc tcaggattgt ccataatgtc
    21181 tgtccccagt tcaaaaacgc ctccaggatt ataacgacaa gagatgattt ctggaatgcc
    21241 tgctactctc tccagatgtt caatatcttc aaaggcatcc aagttaatgg tcgcacccaa
    21301 ttcacgtgca taggcgtatt ccttgtctgg cgtgttgttg gaagagaaca taatctcaga
    21361 acccagaaag tccagtttat ggctcatcaa aagctctaca taactagagc agtccacacc
    21421 acaaccttct tcttggagaa ttttcaaaat agctggagtt ggagtagcct taactgcaaa
    21481 atattcctta aagcccttgt tccacgaaaa agcttggttg acagctcttg ccttctcacg
    21541 aatccccttc tcatcataca agtgaaaggg agtcgggaac tcggcaacaa tcgcttctaa
    21601 ctcttctcta ttgataaatg gtgttttcat aagcttcctt ctattctgtt tgcaaagaaa
    21661 ggctgggaca atcgttccaa cctttagttc tatctcttat ttatcttcgt caaagatatt
    21721 gccaacctca acatcgatgg cttggttctt gacatcaata ttagttacct tcaagagtga
    21781 cttgtagtca aactgctttt cacgttcttc ttgggcattg tccgcaaaga ccgctacacc
    21841 tgccagttct gagtcgaact cgcgcaagag actaatcata ccgttgaccg ttccgccacc
    21901 tttcaagaag tcatccacaa tcaagacacg gctgcctgcc ttaagactac gttttgaaag
    21961 gaacattttc tcgatacggt caccacttga acctgaaaca tagttgacgc taacagttga
    22021 accttcggta attttcaggt cacggcgcac aatgacaaaa gagacattga ggacattggc
    22081 aactgcattt gcaagtggca cacccttagt tgctacggtc ataaccgcgt caattttttg
    22141 gtccataaag cttttggcaa taatacgacc aatatttttc aagatggctg gtgtgctaag
    22201 caaatcagac agatagatat aaccacctgg caagatacgg tcactttctg acaacttggt
    22261 acgcaagtct tcaaccattt ccttagcatc ctgactcgag atagacggtg tgaagatgac
    22321 acctccgcca gccccagtca ctgtctgaat atgaccgatt tcaatttcct caaaggcgcg
    22381 tttgataatg acgatatctt ctgagatgga tgatttagca gactcatact tttcagcaaa
    22441 agtattgaga ctagttagtt tataaggatt attaatcaaa tagttggaaa tgacaaccat
    22501 ccgatcactt cttcttaatt tcatttctat ttcctattcc atttttattc aaaaaatcaa
    22561 aaagcaaact agaaagctgg tcgctggtgg ttcaaaacac tgctttgaga ttgtcgatag
    22621 aactgacaaa ccctgtaata tacctgcata tatacatacg acaaggcgat actaccctag
    22681 tttgaagaga ttttcgaaga gtattcattt ttgtctttta cttattatac catattcaca
    22741 taaaaaaacg aacattctta tcctaaaaaa tgctcatttt tcttaaatta ttaatctaaa
    22801 tctggtttat agaaggaacg attatccata gcgaagattt tattggacat ctctccttta
    22861 tccaccaaag ccagagctgt tgacatcatc atcatgcttg catccagatt gtcaatcata
    22921 tggataatct ctgcctccat aatacgtgga cggactggac ttccatattc aagcaagccg
    22981 tggtgactga ggatgacatg acgaagcaaa acgacttctt ccttggtatc atcgatgccg
    23041 agttccataa ctgtcttggt aatttcgcta tcaatgagag cgatatgtcc aagaagattg
    23101 cctctgaccg tgtactcggt ctggtctggt cccgtcaact cgatgacctt agccaagtcg
    23161 tgcaacataa tccccgcata gagcagactc ttattgagct gaggataaac ttcgctaata
    23221 gcgtctgcca aacgtaccat ggtcgccgta tgataagcca accccgtttc aaaggcatgg
    23281 tggttggtct tggcagctgg ataggagtag aattccttat catacttggt gtagagattt
    23341 cggacaatcc gttgccagac aggattttca attttgaaaa tcatttgcga catgtagtca
    23401 cgaatttcct tgacatcaac tggtgacttg accttgaaat cggctgggtc attgggttca
    23461 ccagcttgag gcaggcggag agtaatttga ttgacttgag gggtattgtt ataaacttct
    23521 cggcgtcctt tcatgtggac aaccttacct gcggtaaagg cctcaatgtt atgaggttgg
    23581 gcatcccaga gcttcccatc aatctcgcca ctatcatctt ggaaggtaaa ggctaggtag
    23641 tttttcccag ctcgagtttg cctcaggtca gctgatttga ttaggtaaaa gccttcaaat
    23701 agctcatctt ttttcatgtg actaatcttc atattcttcc tcattttctt gaaaatggag
    23761 tagatcaagc gcaggctcgc cttctgacaa ctcaatgtga cggagcgtcc gctcgatagc
    23821 tatggtacga cggtttaata gttcatcaat attgccagag gcatgttgga gatgtttttg
    23881 tgccttaacc agaatgccac caaacttgcc aaactcggtc ttgacactgg caagagtctt
    23941 gctgatatgg tcggcactct tttggatatt aagggtcttg aaaccaactg atagggagtt
    24001 aagaagggct gatagggtac ttggtcctgc aacgataatc tgttcttccc gtctcaaatt
    24061 atcaaagaag accggattgc ggacgatttc tgagtagaga ccttctgtcg gaacaaacaa
    24121 aactccaaaa ttggtcgtcc gaggtggtgc tatgtacttg ttcctaatat ccctagcaaa
    24181 gcgcttgacg cttgctagga gtgacttacg acagcgttca atctcatcct tgtcacctgt
    24241 ctcataggct tcttccaagc ggtaataatc tgccagtgga aacttagagt caattggcag
    24301 atagacgtat tcttggtcgc cttgtccggg taacttgatg gcatactcca ctcgttcact
    24361 agagttttca accgttgcgt attctcgttc gtactgggca ggtgtcatga tgtcttcaat
    24421 aatttgcccc agttgcaatt ctcccagaat ccctcgcgtc ttggttccag agagaacctt
    24481 gttaagagct ccgacatcac gggcaactgt ctgcatttct ccaaggccac gattgacaga
    24541 ctccagttgt ttagaaactg tctcaaagga agcctgtaag cgtgtctgca aggtcttttc
    24601 tagtttttcc tcgaccgtct ggcgcatttg ttccaaacgt tgctcatttg attcctgcaa
    24661 ggcttggaga cgttggtctg tcttgtctct agtttggagg agattatctg tcatttcttg
    24721 acggacttgg gtcagacctt ggtgcaattc aatccgcact tcttgcaaac ggtcgctgac
    24781 aaccacttcc aaatcttttt ggtctaactg gctggcttgt ctggcttggt caaagcggta
    24841 atccaactgg tctgacaaat gatctgcctg atcctccaag ctcttactta agtgtttctc
    24901 ctgcctatcc tgcctttgcc aaatcagaaa gagaccagct aggttggcaa ttaataatag
    24961 aataagtaaa ctttccatcc tacctcctgt ccttgctatg cagtacgacc acataaccat
    25021 ctgggcaagt caccgacact tccctatcta tatattcgtt agaagcgtac acttttttaa
    25081 agaaaaaatt ctcctctgtc aactcatact tagctccaag aatagtcagc tggctatccc
    25141 gaactggcat aaaggctaga tagtcgtagt ctgaacgagg ttctagctga ctggtccctt
    25201 ctgaacaata ggcaatcaaa ttttgcccat cctcaatttc tatttgacgc atatagggtg
    25261 ccaacttagg attgctaggt agaaagacat tggccaacat atggtcaata cggccaccca
    25321 aggcaccgaa aatagtgacc tgagcctgag gattttgttc aaagatggtt aagagagcca
    25381 attccagatc tgtatcatcc ttttctggtc gggcttggac aaaatactgg gcacgttttt
    25441 gaatcacctg tcgctcttct gcagtcacag aatcaaaatc tccgactgct agagcaagag
    25501 gtaagtcttc ttccaagacc cagagcgagc ctcgatccac cccaacaaaa gcatcaaaat
    25561 ctgtccgata atgaccgcgg tttccgcctg caaaaactgc aaccctagtc cagttgtttt
    25621 ctgagagttt gtactcgctc attgacttct cccttaaaga cataggaacc tgctacaaaa
    25681 acagtcgcac cagcttcttt ggcttgagca atagtttggt catcaatccc accatccact
    25741 tcgatttcaa agtttaaacc tttttcctga cgaagagcaa ccaactcacg aaccttatcc
    25801 atggtttctg gcagaaaggc ttgcccacca aaacctggat taaccgtcat gactaaaact
    25861 tggtcaacta gatgaaggac gtgcttgatg gcttcaactg gtgtgccagg attgataacg
    25921 actgaaggct taactccgag tgaacgaatt ttttggaggg cgccatgaat atgaggcgtt
    25981 gcttctacat ggatactgat gatgtctgca cctgcacgcg caaaatcttc cagatgatgc
    26041 tcagggtttg acaccatcaa gtggcaatcg aaaaccatct tactatgagg acgaaggctc
    26101 tcgaccacac ctgcaccaaa actgatttgc ggtacaaaat gactgtccat gatatcgata
    26161 tgggcatatt ctgccccagt tgcttctaga cgtttgattt cacgttcaaa gttggcataa
    26221 tctgctgcca gaattgacgg agcaatcttg tattgagaca taggtttctc cttattttgg
    26281 aatttttttg ctgacttttt tataggtttc tctacgattt tcaatttcgc tgaggaattg
    26341 caggtagttg tcaaaacgga aggtggcaat ggtcccctct tctacagctg gcttgacggc
    26401 acaagacggc tcatgggtat gggtacaagt acgaaactta caatctcggc tgacagtagc
    26461 aatctctgga aaggcctgat tgaggtcttc agcccttgat acttcatagt ccagagatga
    26521 aaagcctggt gtgtctgcga ttttaccccc attgagattg taaaaactaa cagctcgagt
    26581 agtatggcgc ccacgaccca gactgtctga gatttctcct gtttcaagat tgagatctgg
    26641 tgcgattttg ttgagaagag ttgacttccc aacacctgtc tgccccataa aaaccgtaac
    26701 cttgcctgtt aacaaaggca ggagttcctc tttactggtc acaaagtcat agccgatgtc
    26761 accataggtc tgctggtaaa aatccagttc tcccctatct tccaacaaat ccattttgga
    26821 aatatagaca atgggatgga tgcccttgtg ctccaaaaga accaagaaac gatccagcaa
    26881 attgctgtta aaatcaggtt ccttgacgga catgattact acagcttgat cgatattgac
    26941 aataggcgga cgaaccagac tgtttttccg ttcgtgaatt ttgaggatat agccttctga
    27001 attttcctcg gcagagaaat ctacccagtc cccaacataa ggggtatggc cttttttacg
    27061 gaaattccca cgcgcgcgtg tttgataaac ctggccatca ctctccacat agtagaaacc
    27121 tgccaaggct ttaatgattt gtccctgcat cttagagtcc ttgcccttta agtgcgtctg
    27181 ctagaccggc aaattctgcc aagctgagag cttccccacg cacacttggt gacaagcctg
    27241 cctggtccaa agccttggtc agcttgtcct tgacctcttc agtcttacca aagtaacctg
    27301 tcaagttatt ccacaaggtc ttgcggcgat gggtaaaact agccttggaa accttaaaga
    27361 aaaagttctc atcttctact gctacggctg gctctggacg acgcaccatt ttcaagatgg
    27421 ctgaatccac atttggcgct ggcacaaaga ccgtacgagg cacgataaag gcaaccttgg
    27481 ctgtcatgta atactgcacg gcgatagaca agctaccgta agccttggtg ttaggctggg
    27541 ctgaaatgcg gtccgctact tctttctgca tcatgaccac aaactcacaa aaaggaatgc
    27601 cactctcaat caagtgcatg agaataggcg tcgtgatgta gtaaggcaaa ttagccacta
    27661 ccttgattgg caggtcagga tttttaaaat tctggatatg ttgcgccaaa tcaaccttga
    27721 gaatatcttc gttaactacg gtcacattat caaaatcacg cagagtatct gccaaaattg
    27781 gcaccaaacg gtggtcaatc tcaaaagcca tgacttgggc tgcacgctca gccaaaaatt
    27841 ctgtcaaggc accaatacct ggcccgattt cgatgacatt gacctgatca tcaatttcag
    27901 ccgtatccac aattttttga aggatattgg tatccgtcaa gaaattttgc ccaaaggact
    27961 ttttaaaggt aaaaccgtga cgctccaaca ctgccttggt cacgctataa tctgcaattc
    28021 tcatctattc tcttttctat tatctgttac tactattgta acacattccc cttgtatttt
    28081 gggaatgaaa atcataccaa aaaactatct ttcctcatga agaaagatag tcttggaaat
    28141 ctttaaagag ggacttagcg cttctctcga aacatacgtt catactcttc gaaaatctct
    28201 tcaaatcacg tcagcttcac cttgccgtac tcaagtacag cctgcggcta gcttcctagt
    28261 ttgctctttg attttcattg agtatcaaaa aaatcagctt cttgataact tcgattttcg
    28321 ggtagggtca aatccacatc ctcctccaca tcatccactg tcagttcaac cgtttgaggt
    28381 aaatttttca aacgataatg cttttgcctt tacccttcaa tactagcaaa atcaagcaaa
    28441 tagccatgca ctcggatttg aaccaaaagg agatgattgg tcatattttc catgatgagg
    28501 atatcttcta aaccacctct ggcactagga taatcagata ccctgcgaat acggattttt
    28561 tcacacatga gcaagtttcc tcatatcaat gatttcatca gccttattcc agactagggg
    28621 attatgggtc gcaatgatga taattcgatt ttcatctttc aaatccacca agagattcat
    28681 aacctcctct gaattttcag gatcaagagc tgctgttggt tcatctgcca aaatcaaggg
    28741 tggatttttc aaaatagtct tagcaagggc aactcgttgg gcctctcccc cagataaagt
    28801 atagattttt tgttctaaat ccaaataccc tagattaact ttttctaaag cccccacttg
    28861 cctttccaaa cgttctactt ttgagatttt ctgaccaaca aaacccaaat ccaaattttc
    28921 tttgattgat tggttttcta agaggccaaa attttgaaag agatagccca tctgatctcg
    28981 aaaatactca cgagtgggaa tggtttttaa atctttcccc tgatagagaa cccttcctcc
    29041 atctatcttt tccagctttc ccaagatatt cagcagcgtc gtctttccgc ttccactctt
    29101 tccgattaag gcataaacct tgcccttctc cagcttgaga ttcaaaccag agaaaatcgc
    29161 gcggtcatta aatttctttt ccaatccttg aatatcaatc atcttatttt cctttcaata
    29221 ctgccatgct accagcttct tcttttttgt cctgccttac taaaatcaag agggcgttaa
    29281 gcgtaaacaa agctacaact agagcgctaa tcaaaccatc tcttgtcaaa atactagata
    29341 ggactaggcc aagcaagaga actcctcctt gcgccagtaa atacttgcca tgaagctcat
    29401 agattgtcat accagcaaga cgtttaatca taagctcccg tctgaactgc tcaaaataga
    29461 gaagattcat ggaatcaaat aacaagatag ccgtagacag ggtcaaaatc gtcccaataa
    29521 ggagagagta aaactccacc cgtttgtcat ttagtacctt ggcaaaaaat agctggcttt
    29581 ttaccaagta agaaaccttg tgatacagac cttgctcttt tagagctgtg atgctgtctc
    29641 catatcgatc tagtttcaag gcactattag ccgtagttcc ccacaacatc cctgcaacag
    29701 gtcttgttcc agtcgcttgc ggcgttagaa ctacaataat cggatctttt aggtactggc
    29761 gtgttgtctt gtacccatca ttatagagga aacgttcctg tcctgtttct gtaaaagcta
    29821 gccttacctg tgggaggtag tgtttctgac tcgtcacttc tacactttca gatgaaaagt
    29881 tttgcaggta atctgtaaac aatccttggt agtaggcaga ctgctctcgc aagctctcag
    29941 gcaagatcag cccaaactct ccctcagaca agttttgcat cttgtccata aactctgaag
    30001 aaacggtaat cttttcctct atcagatagc gcggtgagac atagataaca ttccctgacg
    30061 gtgtgtagtc actgagacga ttgccatcta ggtccacttc tactccatct gagaaattgt
    30121 caacattgct cataatataa aaagagtctg tattggctaa ccgttcttca gtaaatgtct
    30181 gccactcacg attatcctta cgcattcctt cttcatcggc aaatgcacta gaccaaccaa
    30241 aggagagacg gtaacggtct gaggactggc tccatttatc gcttgccttc tccatctcct
    30301 gcatttcacg gtagttgggg aggagagctg tcgcactcaa gccgaccacc aatacagcta
    30361 agagttgccc caccatcatt aatgtcatca tacgtttgag agggagtttc cctttcaata
    30421 gatccaccag actattttcc tgtaaaccaa gtagatagac gacacttagt aaggtagaaa
    30481 tccctgccag ggtcaatcca taaagtagaa gagcaatgat gaccagttgc accgttgcca
    30541 taaacaaggc accttgatac cagagaatcc ccaatcccaa aagactggat accagcactg
    30601 agcagataaa ctgtctcaca tcttctaaca ctggtctgag agcaactcca aacaagctct
    30661 caccagctat taagcgaatc cctgcctgac gaagggattt gatccgataa atcagggtca
    30721 gactcataaa ggtcagcaga aaaatagcta aactcagtag caccataggg gtggccgcca
    30781 atagtaagac tatcgaaaat ggatcttctc cattcgaaac aaagccttga tagccaagtt
    30841 ctttcaaggt ggtctgtaag ctcactccat ccaaacttcc tgacacaatc aagtaagacc
    30901 ctaataaatc actcgtttct gcactctcct tggaggaaat ggtcagacct tctggaagct
    30961 ctccctcacc ataagtggca taggtaaaga gtgtttctcc agcttcattt ggctcaacga
    31021 ttcgacgggc gatgagacta ttatgctcta ccgccaagtg actcaaaacc tctgtcacct
    31081 cttcgcgact agctactggt tgatttatca tcattcctgt cacatcaaca gaaggatagt
    31141 taccaaataa aatctcttct cgatggtcaa cggaagttat caccatataa agcgatacca
    31201 ataccattga aatcaaaata aataaacgtt tcatcatttc ctccaaaaag ttacttggtc
    31261 acttagtgag aaggtgacca cagtcactgc gatgttaaga agcttattaa gttctttctg
    31321 ctagcaacat cttcaaatac attatatccg ttttttcaag aactatcaag gacatcaatg
    31381 tccttaaaat ctaaccattt cgtgtcattt ttagcttata tctaaaaaac agccctaaag
    31441 acgaacttta gaactgtttt gatgcgagaa caaggacatt tttgtcactg attcactatg
    31501 tttataaata ttttttgaca tcctcttgcc attcctctgt caatttcttt actagaaatt
    31561 catctccaat tagctgcgca aatgttttag aagactgata aaatgattca gctaaactaa
    31621 aatctctttc ttctcttaat gcttgcttcc acaaaaacat aaatacaaga ggtttctttt
    31681 gataatcttg agttttatcc ataatttctt gtaaacacga tagataatca ttaaaacaat
    31741 cagttactcc taccttttca agacaacaca ttcctgaaat aagagtatct ctaattataa
    31801 agaagttttc taatttagtt acctttttct gttccaaaag aaagagcatt agctcttcga
    31861 tttgatttat aaatttggca agatcttttc taatgagcat ttgataaaaa aacaaacgaa
    31921 tcaacaacat atcatttgtt gaataaactt ctttttctat gatctgaggc atatgttcct
    31981 caagtattaa ctctgcatat tcaggccttc tagttctaga agtatccaaa cacgcctgca
    32041 atacttcaca tgctaattgt tcttctttag gaagattatc aaagtatgtt ttataaatct
    32101 cttccaaaca cgcttccttc ttatcgtact cctcttcttt accatagatt ggttcacgta
    32161 aaatctgata tttcaattct aaataagcag gaggaagagc tgaaaaatcc ggcataaggc
    32221 tataaactgg aactcctagc cggcgagcaa tatagtctaa cttgggcaaa ctcggttgcg
    32281 aagctccact ttcaattcgc gacagttgac gaactgtcag ttcttgctca tctccacaaa
    32341 aatctggacg actaattcct ttttctatcc gaatctcttt aattttttga ccaattaaca
    32401 tcagacgcct cctcttctac ctgcttcgaa aaatactgtg aaacttaaaa aattgtaacg
    32461 gctacatctt tcctactcat aagatttcat agcttcttcc acttctgcca aagtaacccc
    32521 aaacaactct aggcgtttga ggagttgctt gccgttagaa tagccgattc ggagagtctc
    32581 tccgagatat tctctacgct tacggctgtc tgcccctgct agaaaaccaa ggcgaatcaa
    32641 gtcgctacga ctaatgtcaa actgactctc atgttcaaat tgttctgtca cctgagctag
    32701 agccgttttc aggtcttcat agctggcatg ctcaattccc agagaacgcc ccttggtctt
    32761 ggacttggga acagcttcat ctcgcttgag aaaggcatgc tgaactgttg gaatgaccgt
    32821 catgatcatg cgccgaatcc gttccccatt aaaatctggg tctgtaaaga caatgactcc
    32881 atgacgttgg tgcaggcgct gaatccgctc tatatcctga tcattgatgg cagaacctcg
    32941 agtctcatag gtctccacat cgaaataacg tttgagattg accgtatcat cgcgaccttc
    33001 aaccacgata acttgagaaa ttttctcttt cattacttgc tgtccaatcc aaaaattcgt
    33061 tctgcatttg cagtcgttgc taccgccagc tcttctgtcg tcataccacg caagtcagcg
    33121 ataaagtcga ccacatagcg agtataggct gttttatttt cacgaccacg cttgggtaca
    33181 ggtgctaagt aaggcgcatc tgtttccacc aacatcttgt ccaaaggtaa ctctttagct
    33241 gcttcttgga ggtcagttgc cttcttgaaa gtcaccactc ctgagaagga aatggtcata
    33301 ccaagatcca caaacttctc tgcccactca agcgtccctg aaaatgaatg catgatacca
    33361 ccacgaggac caacgccctc actcttgata atctcatagg tatcttccag cgcatcacgg
    33421 gtatggacaa caaaaggcaa atccaagtcc ttagatagct gaatctgacg gcgaaaaacc
    33481 tgctcctgca cctctttggg cgctgtcatc caatggtagt ctaagccaat ttcacctaaa
    33541 gccacaacct tggaatgttt taacttatcc aacaagtaag cctcaacttc ctctgtataa
    33601 gtaccagctt ctgtaggatg ccaaccaata gtcgcataga gctgctcata ctcatctacc
    33661 aactccaagg catgctcaat cgtcggttta tcaaaaccaa caatattcat ctgtgtcaca
    33721 cccatctcag cagccaaggc aatttcttct gtctcacgac ctgcaaattc ttctacattc
    33781 aagtgtgtat gtgtatcaaa aatcatctct tctaacctcg ttttctatct tctattatac
    33841 caaaaaagag gaggggcacc taatttttcg gtttcccctc ctctcttcaa tagagagcta
    33901 ttctgctatc ttttctatcc gatattgccc atctcctatt ccacagttag agacagaaga
    33961 gattggctac attgatagaa tattcctatt cagctaaagt atgtgattat cttgggttct
    34021 cacttttctc acccatcact aggattgatg acttctcaaa atccccctta taatctaact
    34081 ttaagtagag aatagaattt tctagctgtt ctattttcta cgtctagtct ttcttcctag
    34141 caaagcaaaa ccacttgttg ccaccactag accaagacta gcaagtgctg cacttgatgc
    34201 tgaacctgtg ttaggtaatt gtttgccagc aggtgactgg taggtaacat cttgcattgt
    34261 tcctgcagtt gcttgcggtg cacttgttgt cttaggagca gcattaggag ccactggtct
    34321 cttaggaact gtaaccatgg caatggcttg cactccaatc gtttctgctt ccttcacatc
    34381 ttccatagtt ttcgcatttt caatctcttt gagagctgct tgtttttctg cttccactct
    34441 tgctaaaagt tctgcttttt ctttatcaga aagcggtgcg cctttgattt catcctgctt
    34501 gttcttggct gctttttcaa tggcattttt agctgattct ttttcagtag ctaattgctt
    34561 agaagcttgt gattgagctg agttttgtga acctgtgtga gctgatccac ccgcctggct
    34621 accaccgcct tcattcgcat tagcatctga gcttccagta ttgcctccct tatctccacc
    34681 tggtgtagtt tctagcttat actctggtgt agcttcttga gttacagatt cacctttcgc
    34741 agattgttga actgtatctt ttcctagaat cgtcactact gaaccatctg ggaatgtgat
    34801 tgttgctgta ccatctccag ctacattgat tgtcgctccg tctaatgctg aaccatttgc
    34861 ttgtaaaata gcaaccttaa ctttttcttc atctgttaaa tgagttatat cttttacatc
    34921 tactctttga gcaggtgctt taacagttga tttttcagca gtcggtttag tgctatcttg
    34981 tgcttttgga tcttgtgcta ccaattgatt tcctggaatt gtaatagctg aaccatcttt
    35041 aaagacgatt gtcgctgtgc catctccagc tacttcaatt ttatagtaaa ataataacag
    35101 gacaaatcaa tcaggacaat caaatcgatt tctaacaatg ttttagaaac agaggtgtac
    35161 tattctagtt tcaatctact gtaacatcgc ttccgaatcc atttgcatct actgaacttt
    35221 tttacaaaaa taaaaatcag tagactcgag ttcctactga tttttgatag aattcgtttg
    35281 gattatgcag ccaaaacttt gcgtccttta cgacgacgag ctgccaatac gcgacgacca
    35341 tttttagttg acatacggtt acggaatccg tgtttgcgcg cacgacgaag tttacttggt
    35401 tgataagtac gtttcacgat gaatacctcc tcatagattt tgtattcgtt tagccggcta
    35461 taaagtgatc agttactaaa catactttac tattctatct gattctttca cttttgtcaa
    35521 tagctctagg caaatgtttc cagctttttc gaatgcaagc cctatctacg atactgtttc
    35581 aagaaacgag tcatcttttc ttggatttgg gctaactcat caacacgagg aaggtaaacg
    35641 atacggaagt ggtctggttc ctgccagtta aagcctcgac catgaaccaa gagaaccttt
    35701 tcctgcttca agaaatcaag gacaaactgc tcatcatcat cgatacggta catattgcgg
    35761 tcgatttttg ggaagatata gagccccgcc ttgggtttaa cggcagacaa acctggaata
    35821 tcttgaatgg cattatagat gaaatttctt tgctcgtaga ttcgtccacc aggaagaagc
    35881 aattcatcga ctgattggtg accccccaag gaagtttgta cgacttgttg ggccaaaacg
    35941 ttagagcaaa ggcgcatatt ggacagcata ttgagccctt cgatatagcc cttaacatga
    36001 gtcttagggc cagacaagac catccaaccc acacggaaac ctgctatgcg gtgggatttt
    36061 gacagaccat tcatgctgac acagaagaca tctgatgcca agctcgccac aggcgtatgc
    36121 acatgtccgt ccattaccat gcggtcatag atttcatccg caaagataat caaatcgttt
    36181 tgacgggcaa tctcaataat ctccagcaag agttccttag gataaagggc tccagttggg
    36241 ttatttggat tgataaggac aattgccttg gtattggaag tgatttttga cttgatatcg
    36301 tcaatatctg ggtaccattc cacagcttca tcacagatat agtgaacggc atttcctcca
    36361 gctaggctga cagccgccgt ccatagagga tagtctggca ttggcactaa gacctcatcc
    36421 ccattgtcca aaagcccctg catggacatg acaatcaact cactgacacc atttccaagg
    36481 taaatatcat caatatctac gtttgggaat ttcttcagct ggcaatactg catgatggcc
    36541 ttacgggctg agaaaatccc tttggagtta gaatagcctt cactatcacg cgcattcata
    36601 atcaagtcat gaatgacctc gtctggcgct gtaaagccaa attctgctgg atttcctgta
    36661 ttcagacgta aaatcttttc tccattcgct cgcatccgca tggcttcttc caatacagga
    36721 ccacggatat cataagcaac atgctctaac ttactagact tgttatattc tttcatcttg
    36781 tttcctcaat tcatcaggat agtaacatta taccactaga aagagaatgc gacaagttta
    36841 ctgaaatgtg ttactagttt cgtatagaag aaaaaccttg ctaaaggcga ggttaagaac
    36901 gtagagatag caggtatttt gcaaagacac atcacatacc aaaagataaa cctagaaaaa
    36961 gcaagcctag aaaggagtca taaagaagat taaacatgag gaaaagcccc atatcatcaa
    37021 gtaatcccaa cgcccacttc gttttgcaac tagaaataag attagatggt agagtacatg
    37081 aaagactaaa aatccaataa aacctggata aagaagcggt accagactct ctaattgaca
    37141 gatcatgatc acttctacca agactgaaac taggataatt ccataataca ggaaatttga
    37201 tttttgaaaa gagtttttca tcattctccc ttccttcact tctttcctgc tatcctttct
    37261 tttattttat catatattta tatagagttt aagccctaat attcttttga aaaatacttt
    37321 ttttgcttta cttctatagt gaaaaggttt acaattatag taagaaaatt tcaggaggtt
    37381 tcattatggc acaacgttac caaaatatca tggtcgcaat cgatggttct aaggaagcgg
    37441 acttggcttt tgtcaaggga gttcattctg ctctacgaaa cgacgctaaa ctcaccatcg
    37501 cacatgtcat tgacacacgc gctctccaaa gcgtatccac ctttgatgct gaagtttacg
    37561 aagaactcca agtcgacgct gaaagtctga tgaaagagta cgaaaaacgt gctaaagatg
    37621 ctggggtagc agatgttcat atcgtcattg aaatgggaaa tccaaagacc ctgctagcac
    37681 gtactattcc agatgccgag gaagtggacc tcatcctcgt tggcgcaact ggtctcaacg
    37741 cctttgaacg cctcttggtc ggctcttcat ctgaatatat actccgccat gctaaggtcg
    37801 atttgctggt tgtgagagaa caagaaaaaa ccttataatc acaaagaaaa ggagccccta
    37861 gctccttttt gtttacgatt tatttctctc tttatggcgt tcgtaagcct tgagctggcg
    37921 ctgcagttcc tttttaatag caggttctgg agcatatttt tcttcccaat tatctggttt
    37981 taagatttta tgggtcactg gatcaaaatg agccttgcca tctggaaaaa ttttccccat
    38041 attggcctga tggacaatat caaaaatacg ttctgggtcc acccccatca agacaaaact
    38101 gccgtaggtg aagtaaagcg tgtcaatcaa ggcatccact tgccctatca aatcttgctg
    38161 agcaggtgtc ttcttggcta ctttatctgc tgccttatca agggtctgat gaagttgcga
    38221 tacagcttga ccaaaatctt cttcagaagg actggctgct cgaacaaact ccaccaattc
    38281 ttctatttta aaaccagccc tatgggttgc accctctaaa tcccaagctc gaggttcttc
    38341 ttgggttcgt tcatccatca tgtggtggaa ggtcttgacc ttattgaaat gatagtcacg
    38401 gctgacaaag actttttctg aagacaaaac accaaaatgt tccaaggcct tgtggattcc
    38461 atcttgttga ttgctagtgg taatgtgctt ggcagcttcc ttgacactgc tactaccatt
    38521 tcccatagcg accgacatac cgacgccagc cagcatttca agatcattat ctgagtcacc
    38581 aaaagccatg acttggttga ggtcaaagcc atattctttc ccaactcggc gaatgccttc
    38641 taatttagaa tttccctgat tgatgacatc cgatgcaaaa ggattgctac gtgtcaattt
    38701 caagtcttca aaatcagctg ccgccttctc agattcttct ggtgtcatca gcatcaaaac
    38761 ttggtagata ggctgattca tcaggtgaag caggtcctct tccttttggg gaacaacctt
    38821 gctgaccatg cgattaaaag actgactcac cgtccgagtt aaaacagagg gaacgaagcg
    38881 actaattcgt tgggaaaaag aacccagacc aaaggacatg attttagaac ccaacatggc
    38941 atccttggtc cctagagcaa tctccgtgcc ctctttttta gcatagctaa ttagatggcg
    39001 caaatgtaac ttggaaatag ggctcgtgaa caagactctg tctttactaa agatatactg
    39061 gccattatag gttaccgcaa aatccagatc caaatcgtcc atcaattcct taacaaaaaa
    39121 aggtcctcgc cctgtcgcta cgccaactag taccccttgt tctttgacaa tcttaatcgc
    39181 gtccttagtg gatttcaaaa cactcttgcg attgttgacc aaggttccat cgatatcaaa
    39241 aaaaacagct ttgacttcca tcctattcca atctcccctt ttgtgataca atgattatac
    39301 cacatttcag aaagagtgag taaatcatgc ctaagaaaat ccttgtttta catacgggtg
    39361 gaactatttc catgcaggcc gatgcttctg gcgctgttgt gacgagttca gataatccca
    39421 tgaaccatgt gtccaaccca cttgaaggaa tccaagtcca cgccttggac ttttttaacc
    39481 ttccaagtcc ccatatcaaa cccaaacata tgctggtcct ctaccagaaa attaaagagg
    39541 aagcagataa ctacgatgga gtggtgatca cacacggaac cgatacttta gaggaaacag
    39601 cctatttcct tgataccatg gaagttcccc atatgcctat cgttctaaca ggagccatgc
    39661 gtagctccaa tgagctcggt agtgatggtg tttataatta cctaagtgct ttacgagtgg
    39721 ccagcgatga cagggctgct gacaaaggag ttttggtcgt tatgaacgat gaaatccacg
    39781 ctgccaagta tgtcaccaaa acacatacga ctaatgtcaa caccttccag actccaacac
    39841 atggccccct cggtctcatc atgaaacagg aaatcctcta cttcaaaaca gctgaacctc
    39901 gtgttcgctt tgaccttgat cacatacaag gtttagtccc tatcatctcg gcttatgctg
    39961 gtatgacaga tgagctgatt gatatgctgg atttagaaca cttggacggt ttgattatcc
    40021 aagccttcgg agctggtaat attcccaaag aaacggctca aaaattagaa agccttctgc
    40081 aaaaaggaat cccagtcgct ctggtatcac gatgctttaa cggtattgcc gagcctgttt
    40141 atgcctacca aggtgggggc gtacagttgc aaaaagcagg cgttttcttt gttaaagaac
    40201 tcaacgccca aaaagcccgc ttgaaactcc tcatcgccct caatgccgga ctaacaggac
    40261 aggctttgaa agactatatg gaaggctaat actcttcgaa aatctctgca aaccacgtca
    40321 cgtcgcctta ccgtatgtat ggttactgac ttcgtcagtt ctatctacaa cctcaaaaac
    40381 atgttttgag ctgacttcgt cagttctatc tacaacctca aaaacatgtt ttgagctgac
    40441 ttcgtcagtt ctatctgcaa cctcaaagca gtgctttgag ctgacttcgt cagttctatc
    40501 tacaacctca aaacagtgtg ttgcgcagcc tttaaccagc cgcctagtcc gctctatggt
    40561 attcattaag tcaacatctc ttgtttaaga gcacaaaatc aggaaatctt ctcgattccc
    40621 tgattttttc tatttacgtt ttcgtgttga gctacgttct gtcaaaccat gaggtaagag
    40681 aacttcacgt tcttccaact cttccttatg cataatcttg gtcaacatac gcatactaat
    40741 ggcaccaagg tcataaagag gttgggcaat cgttgtcaag tttggacggg taaagcgtga
    40801 gatttgtgaa tcatcactag taataatttc aaaatcttct ggcacagaaa cacccttatc
    40861 agccaaaccg ttcaagactc ctgctgccaa ctcatcacct gtcacaactg ctgcagttgc
    40921 atttgatgaa atcaaacgct ctgctaaggc gtaaccatca tcatagctat atttagattc
    40981 aaataccaaa ccctcactat aagcgattcc tgcttttttc aaggtttcct tgtagccaac
    41041 taaacgaacc ttaccattga tgtcatccac tagcggaccg ctaacgaaag caatacgctc
    41101 attttcttta gcaaggtaac tcactgcatc aattgttgct tgcttatagt caatattgac
    41161 acttggcaac tggtgctcaa catcgacagt tcctgcgaga acaatcggag tacgtgaacg
    41221 cgaaaattct gagcgaattt tatctgtcaa gtgataaccc atatagataa tgccatctac
    41281 ctgctttgaa aagagggtat tgacaacaga aacttctttc tcgttatctt catcgctatt
    41341 agctaggaca atattgtact tgtacatttc tgcaatatca tcaatcccct tagccaaact
    41401 cgaaaaataa ccattggtaa tatttggaat cacgacaccg acagtggttg tctttttact
    41461 tgcaagacca cgcgcaactg catttggacg ataatccaag cgatcaatta cctctagcac
    41521 ttttttacgg gtattctctt ttacattttt attgccattg accacacggc tgaccgtcgc
    41581 catggaaaca cctgcttcac gagcgacatc ataaatggtt actgtatcat ctgcattcat
    41641 tccttttcct gtcctttcta tctcacacat tcttttacaa gtagaggtac tgattgaagc
    41701 tctatatcta cttacaaaag tgaagatgtg aaaatttcgt tttcatattt ctacttattc
    41761 cattctatca ctaattgtaa acactttcaa gtgttttttg aagattgatt gaaaaaattt
    41821 catagaaaac ctaggtttag ctccttgcta ccaccttaga ctaaacaaaa aggaggaaac
    41881 taagccctcc taaagttata gtaaaatgaa ataagaacag gataaatcga tcaggacagt
    41941 caaatcgatt tctaacaatg ttttagaagt agaggtgtac tattctagtt tcaatctact
    42001 ataggtattg ttccattcac taccgtcaat tttagcacat agtcttcatg aaaatattat
    42061 atcatcataa ccaaccagat tcttttgcga tattagctgc ctctgttcga ttaccagcat
    42121 ccaattttga aagaatattg gtgacatagt ttcgaatagt tccgtttgag aggtaaagct
    42181 gatctgcgat ttcttggttg gataagcccc gggcgatccc ctttaagaca gcaatctctt
    42241 gttctgtcaa cggattggga cgggtcatca ccacttccat caattcaggc gaatactcct
    42301 tgcgtccttc gaggacggtg tgcaaggttt gcatgaggtc tgcaacgctt cgttccttta
    42361 atacataagc atccactcca gccttgaccg cacgttcaaa atacccagca cgcttgaagg
    42421 tcgtcaccac aaccaccttt gtttcaagcc tttctgatcg tatccactcc aagacttcaa
    42481 gacctgtctt aacaggcatt tctacgtcaa ggatggcgat atctacagac tccttttcta
    42541 atagttggat tgcttcttgc ccattcttgg cttgaaggac agactccaca tctggttgaa
    42601 gcgtgagtaa ttgacacatg gcatctcgca acatactttg atcttctgcg actaatactt
    42661 tcatcttagt ttctctcctt ataaggtagt cgaacttgca cttccgttgg atgtttctga
    42721 ctgattacac ttacttctcc tgaaaatgga aaaacacgat ctcggattgt atggagctca
    42781 tctcctttta gaaaagcaaa gccgcagcca tcatcactta ctgttaaaat gagttccttc
    42841 tctgtccgtt ctaattttaa gtaagcttta gacgctttgg catgtttgat gatattggtc
    42901 accaactcaa gcaaaatcat agaagccatt gactccaatt cttgagtaag gctagcagta
    42961 tctagttggt tatctgtttc cacctcaatt ccagcaattt ctaacatctt tttcacagtc
    43021 tctagttcgg atgtcaaagt tctagactta agattttcca caatggttcg aacttcacgc
    43081 attgattctt tgctaatttg ctgtatttct cttaattcct tttccacttg tggataagcc
    43141 tgcatttgaa atagctgcaa ggctagatct atcttgacac taagcatagc aaaggtatgt
    43201 cccagactat catgcaaatc ctgaccgata cgattgcgct cattttctgc tagcaataga
    43261 tttatctggg tattttgctt gacctgagct tctttcaaat cctcgacaag gcgaattcga
    43321 accgagccca aagtcatcaa atcgacaaaa gtaagaatta caagcatata gactagaaac
    43381 tcaacttcga ttctctgaaa aatcaaaagt cgccccacaa caaggacttg agcaaggaga
    43441 aatgtccata catgtaaaga ctttaaacta cgtacgccaa aatgataaat taagatattg
    43501 gaaaggaaaa agaaaaacca gatataattc ccagcaacaa aggcggtatt cccagctaca
    43561 tagaccagca tgatccccca gaaaagccaa gataggcgct ggttcttagt tattaaaaca
    43621 cccaaatacg tcactacaaa tagaatatca accaataaat gccaagcagg aagctcccca
    43681 atcactacag gtaggatggg aaaaagcata aaaatcaaac tggtccaaaa catatagtgt
    43741 atgcttttca gtctttcaag cattaagcat tctccttatg accttgaagg taaatagtca
    43801 aaccaaataa aactgctgaa aaaacaagta aataaactgt ggctgataga ttgatgccac
    43861 cctcgtttaa gaaggtcttg agcaactcca tcaattgata ggtcgggaga cacttaccaa
    43921 ctgcttgcat ccagtctgga aataaagaaa tgggcatcca gagtccgcct aaaacagcca
    43981 atcctagata aagaagattg cccacaacag acatcagctg actagttggt aagagagtca
    44041 aggtcaagcc aagtgctaca aaagcaatac tccccacaat cagcaaaatc gcagctccaa
    44101 cccattttac tagaggcatg tctacacctc ttacaaaatg tccaactgta aaaacaacca
    44161 gaattgagac caaataatca accagcatac ttgttatctt tgatagataa tattctacca
    44221 tatttacagg gctatgacgc aatgttttct gccagttgtt catcttatcg gtatgtaaaa
    44281 cagctggaaa tgagaagata gttgtcgaca tcatggaaaa ggcagtcatg gagatgaggt
    44341 aatcacgcat aaaattcgcg ggttcacctg gtgtgtcctg atagatacca gaaaaaaata
    44401 aatagaaagc cgtcggcatc cctaccgaca atagataata gattaattgt cgtttggtca
    44461 ataaaaattc tatcttacta agtgctatcc atcgtttcat cttagttatc tcccttctgc
    44521 gtctcttcaa agattgtatt caacaaacta cgattattaa cttcgatttc ttgcatccta
    44581 catcctgctt gggctaatag ttcccagaaa gcatctgctt ctcgagtgac tacttgtaaa
    44641 gaatcttgct ttagggtcca gttttcaacc aaatttgact gctctacgac ttccttgtaa
    44701 gctataggaa ggataaagtg cttttctatt tcctcgctac gcatagctag aggcgtcgta
    44761 tctcgaatca actctccctt atttaagagc aaaatgcggt ctgcagtgtg ttccacttcc
    44821 tcaatataat gggacgaata gagaatggtg attccttgcg cttttaactc ctggacaatt
    44881 tcccaaaaac gttgacgagt tgaggtatcc atggacgcag taggctcatc taaaaaaaca
    44941 atctttggtc gcccaattaa ggtcaagacg aaagaaaaga gacgcttttg accgcctgat
    45001 aatttttctg ccaactgttc tttttgttgc ttgacaaact gcaatagttg atcaatttcc
    45061 tgattgctca aaggatttgg atagatacgt tgaaagaaag caatcaactc tttaactttt
    45121 aatttctgaa cgattacatt ttcttgaggg aggtaagccc tagtatagtc taacttagaa
    45181 ctcgtcactg gtaaaccttg aatagatact tgaccgcttg tgaccagttt atctccaagc
    45241 aaacaatcta agagtgttgt ctttccggca ccatttggac caattaaggc aacacattca
    45301 ccatcgttga tttcaaagga gatattccgc aaaatttcct tgtcttttat tttcttactc
    45361 aatttctcaa ctttaaccac cgtcatgaga ctctcctttc aaccactcca ttcccataag
    45421 gaaaacgacg aaaatcataa atccaaaccc caaagcacca cgaatgaatt ggcgaagcaa
    45481 ggcttgatca aaccaatcag taaacatttc cactaaccat accaagagtg acaggccgat
    45541 aaagaaatag atgatccctc tcttcattct tcaaactcct ttttcacatc tctgactaat
    45601 ttcaaacctt ctctaacaag ccaagacatg attccaaagc cagcaaagac cttccaagga
    45661 aaatggtaga aatcctcatc caatcccgaa aacatgagat aggtcataac tcctgctact
    45721 actaaactca ctgcgataat cattttattt ctcatctctt cttcccccat ttcatactac
    45781 aattatagtc ttttaaaatc agaggaggca gaagcttctg tcactagaaa atatgacaaa
    45841 tgtcataaaa aattttgttc aaaacaagca agatacacta tacaataaaa cacaatcaga
    45901 aaaatctaag gcaacttcct caaaagagat atcaaaccca attcacacca taatgtaaac
    45961 taatacttat ttaaaatcaa aaagagtaga aatttttatc agacaaacac atatatagtg
    46021 tattgaatct ataacagtag gccttaaata ctaaaatatt tctataaatt aa
//
LOCUS       DAVHIZ010000012        43391 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.012, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000012 DAVHIZ010000000
VERSION     DAVHIZ010000012.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 43391)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43391)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43391
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.012"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(141..1367)
                     /locus_tag="VVO18_000656"
     CDS             complement(141..1367)
                     /locus_tag="VVO18_000656"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001134527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="HEU5585857.1"
                     /translation="MPNYNIPFSPPDITEAEIAEVADTLRSGWITTGPKTKELERRLS
                     QYTQTPKTVCLNSATAALELILRVLEVGPGDEVVVPAMTYTASCSVITHVGATPVMVD
                     IQADTFEMDYDLLEQAITEKTKVIIPVELAGIVCDYDRLFQVVEKKRDLFTASSKWQK
                     AFNRIVIVSDSAHALGSTYKGQPAGSIADFTSFSFHAVKNFTTAEGGSATWKANPAID
                     DEEMYKEFQILSLHGQTKDALAKMQLGSWEYDIVTPAYKCNMTDIMASLGLVQLDRYS
                     GLLQRRKDIVDRYDRGFAGSRIHPLAHKTETVESSRHLYITHVEGASLEERNLIIQEL
                     AKAGIASNVHYKPLPLLTAYKNLGFDMANYPKAYAFFENEITLPLHTKLSDEEVDYII
                     ETFKTVSEKVLTSSKK"
     gene            complement(1410..2102)
                     /locus_tag="VVO18_000657"
     CDS             complement(1410..2102)
                     /locus_tag="VVO18_000657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000922225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEU5585858.1"
                     /translation="MLKWEDLPVEMKSSEVESYYQLVSKRKGSLIFKRCLDWVLALVV
                     LVLTSPIFLIMSIWIKLDSKGPVIYKQERVTQYNRRFKIWKFRTMVTDADKKGSLVTS
                     ANDSRITKVGNFIRRVRLDELPQLVNVLKGEMSFVGTRPEVPRYTEQYSPEMMATLLL
                     PAGITSPASIHYKDEDTIISQMTEKGLSVDQAYVEYVLPEKMRYNLAYLREFSFLGDI
                     KIMFQTVFEVLK"
     gene            complement(2286..4028)
                     /locus_tag="VVO18_000658"
     CDS             complement(2286..4028)
                     /locus_tag="VVO18_000658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585859.1"
                     /translation="MQNKKEQWAVLKRLMSYLKPYGLLTFLALSFLLATTVIKSVIPL
                     VASHFIDQYLSNLNQLAVTVLLVYYGLYILQTMVQYVGNLLFARVSYSIVRDIRRDAF
                     ANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVL
                     DFRLTTLVLIFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFN
                     QEKRLQAEFDEINQEHLVYANRSVALDALFLRPAMSLLKLLGYAVLMAYFGYRGFSIG
                     ITAGTMYAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPLQENGQA
                     VIKEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYE
                     FQSGRVLLDSVDIRAYSQEELRTNIGLVLQDPFLYHGTIKSNIAMYQEISDEQVRAAA
                     AFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANID
                     SETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLALGG
                     TYHKMYSLQAGAMS"
     gene            complement(4018..5763)
                     /locus_tag="VVO18_000659"
     CDS             complement(4018..5763)
                     /locus_tag="VVO18_000659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022567.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585860.1"
                     /translation="MSIIQKLWWFFKLEKRRYLVGIVALVLVSVLNLIPPMVMGRVID
                     AITSGQLTQQDLLLSLFYLLLAAFGMYYLRYVWRMYILGTSYCLGQIMRSRLFKHFTK
                     MSSAFYQTYRTGDLMAHATNDINALTRLAGGGVMSAVDASITALVTLLTMLFSISWQM
                     TLVAILPLPFMAYATSRLGRKTHKAFGESQAAFSELNNKVQESVSGIKVTKSFGYQAD
                     ELKSFQAVNELTFQKNLQTMKYDSLFDPMVLVFVGSSYVLTLLVGSLMVQEGQITVGN
                     LVTFISYLDMLVWPLMAIGFLFNTTQRGKVSYQRIENLLSQESPVQDPEFPLDGIENG
                     RLEYTIDSFAFENEETLTNVHFSLEKGQTLGLVGQTGSGKTSLIKLLLREYDVDKGTI
                     YLNGHDIRDYRLTDLRSLMGYVPQDQFLFATSILDNIRFGNPNLPLSAVEEATKLAQV
                     YQDIVAMPQGFDTLIGEKGVSLSGGQKQRLAMSRAMILDPDILILDDSLSAVDAKTEY
                     AIIDNLKETRKDKTTIITAHRLSAVVHADLILVLQNGQIIERGTHDDLLALDGWYAQT
                     YQSQQLEMKGEEDAE"
     gene            complement(5969..6265)
                     /locus_tag="VVO18_000660"
     CDS             complement(5969..6265)
                     /locus_tag="VVO18_000660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001276342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF421 domain-containing protein"
                     /protein_id="HEU5585861.1"
                     /translation="MSASDVALKLRSQGIFQMKQVKRAVQEQNGQLIVVQMGDENPKY
                     PVVTDGVIQVDVLESIGRSEEWLLDNLSKQGHDNVANIFIAEYDKGAVTVVTYE"
     gene            complement(6418..6873)
                     /locus_tag="VVO18_000661"
                     /pseudo
     CDS             complement(6418..6873)
                     /locus_tag="VVO18_000661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3290 family protein"
     gene            7007..7834
                     /gene="xth"
                     /locus_tag="VVO18_000662"
     CDS             7007..7834
                     /gene="xth"
                     /locus_tag="VVO18_000662"
                     /EC_number="3.1.11.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006596696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease III"
                     /protein_id="HEU5585862.1"
                     /translation="MKLISWNIDSLNAALTSDSARAKLSQEVLQTLVAENADIIAIQE
                     TKLSAKGPTKKHVEILEELFPGYENTWRSSQEPARKGYAGTMFLYKKELTPTVTFPEI
                     GAPSTMDLEGRIITLEFDAFFVTQVYTPNAGDGLKRLEERQVWDVKYAEYLAELDKEK
                     PVLATGDYNVAHNEIDLANPASNRRSPGFTDEERAGFTNLLATGFTDTFRHVHGDVPE
                     RYTWWAQRSKTSKINNTGWRIDYWLTSNRIADKVTKSDMIDSGARQDHTPIVLEIDL"
     gene            7846..8097
                     /locus_tag="VVO18_000663"
     CDS             7846..8097
                     /locus_tag="VVO18_000663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000386134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glyoxalase"
                     /protein_id="HEU5585863.1"
                     /translation="MDYNAVIPELLVSNIEQSRSFYCGLLGFRIEYQRPEENFLFLSL
                     EECQLMLEEGTKDQLAELTYPFGRGVNLSFGIKDVSKLY"
     gene            8104..8232
                     /locus_tag="VVO18_000664"
     CDS             8104..8232
                     /locus_tag="VVO18_000664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646799.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-1-phosphate uridylyltransferase"
                     /protein_id="HEU5585864.1"
                     /translation="MKANYPIYRPLTKRKFRVSDPYIYPHKFAVLDPNGYFLRFSE"
     regulatory      8615..8710
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00167"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="purine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="guanine and/or adenine"
                     /db_xref="RFAM:RF00167"
     gene            9110..9691
                     /locus_tag="VVO18_000665"
     CDS             9110..9691
                     /locus_tag="VVO18_000665"
                     /EC_number="2.4.2.22"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="xanthine phosphoribosyltransferase"
                     /protein_id="HEU5585865.1"
                     /translation="MKLLEDRILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAE
                     KFAAAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQ
                     VTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQD
                     GRDLLEKAGYPVLSLARLDRFENGQVVFKEADL"
     gene            9691..10953
                     /locus_tag="VVO18_000666"
     CDS             9691..10953
                     /locus_tag="VVO18_000666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001194492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine permease"
                     /protein_id="HEU5585866.1"
                     /translation="MQTQEKHSQAAVLGLQHLLAMYSGSILVPIMIATALGYSAEQLT
                     YLISTDIFMCGVATFLQLQLNKYFGIGLPVVLGVAFQSVAPLIMIGQSHGSGAMFGAL
                     IASGIYVVLVSGIFSKVANLFPSIVTGSVITTIGLTLIPVAIGNMGNNVPEPTGQSLL
                     LAAITVLIILLINIFTKGFIKSISILIGLVVGTAIAATMGLVDFSPVAVAPLVHVPIP
                     LYFGMPTFEISSIVMMCIIATVSMVESTGVYLALSDITKDPIDSTRLRNGYRAEGLAV
                     LLGGIFNTFPYTGFSQNVGLVKLSGIKKRLPIYYAAGFLVLLGLLPKFGALAQIIPSS
                     VLGGAMLVMFGFVSIQGMQILARVDFANNEHNFLIAAVSIAAGVGLNNSNLFVSMPTA
                     FQMFFSNGIVVASLLAIVLNAVLNHKKK"
     gene            complement(11004..11465)
                     /locus_tag="VVO18_000667"
     CDS             complement(11004..11465)
                     /locus_tag="VVO18_000667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850937.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein DpnD"
                     /protein_id="HEU5585867.1"
                     /translation="MKTKQLVASEEVYDFLKVIWPDYETESRYDNLSLIVCTLSDPDC
                     VRWLSENMKFGDEKQLALMKEKYGWEVGDKLPEWLHSSYHRLLLIGELLESNLKLKKY
                     TVEITETLSRLVSIEAENPDEAERLVREKYKSCEIVLDADDFQDYDTSIYE"
     gene            complement(11462..12226)
                     /locus_tag="VVO18_000668"
     CDS             complement(11462..12226)
                     /locus_tag="VVO18_000668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type-2 restriction enzyme DpnI"
                     /protein_id="HEU5585868.1"
                     /translation="MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNH
                     FENNRPVADFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLTYT
                     KNFEVNNFLVLPKQFVTPKSIIQRKPLAPTARRAGWIGCNIDLSQVPSKGRIFLVQDG
                     QVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIEGSEFTLEDMYRFESDLKN
                     IFVKNNHIKEKIRQQLQILRDKEIIEFKGRGKYRKL"
     gene            complement(12407..12811)
                     /locus_tag="VVO18_000669"
     CDS             complement(12407..12811)
                     /locus_tag="VVO18_000669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000651202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PaaI family thioesterase"
                     /protein_id="HEU5585869.1"
                     /translation="MKDFHFDAISAFENYEIEKMRDGHVVVTTKVVNSSLNYYGNAHG
                     GYLFTLCDQISGLVVISLGLDGVTLQSSINYLKAGKLDDVLTIKGECVHQGRTTCVMD
                     VDITNQEGRNVCKATFTMFVTGQRSEERRVSI"
     gene            complement(12881..14362)
                     /locus_tag="VVO18_000670"
     CDS             complement(12881..14362)
                     /locus_tag="VVO18_000670"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HEU5585870.1"
                     /translation="MTLVDKFVTHVISESSFEEMDRIYLTNRVLARVGEGVLEVETNL
                     DKLIDLKDQLVEEAVRLEMIEDSQTAREILGTELMDLVTPYPSQVNRDFWEAYVHSPE
                     QAIEDFYQLSQKNDYIKLKAIAKNIAYRVPSDYGELEITINLSKPEKDPKEIAVAKLV
                     QASNYPQCQLCLENEGYHGRVNHPARSNHRIIRFEMVGQEWGFQYSPYAYFNEHCIFL
                     DGQHRPMAISRQSFERLLAIVEQFPGYFAGSNADLPIVGGSILTHDHYQGGRHVFPME
                     LAPLQKTFRFAGFEQVKAGIIKWPMSVLRLTSDSKEDLINLADKIFQEWRQYSDSSVQ
                     ILAETDGTPHHTITPIARKRDGQFELDLVLRDNQTSAEHPDGIYHPHKDVQHIKKENI
                     GLIEVMGLAILPPRLKEEVEQVASYLVGEAVTVADYHQEWADQLKSQHPDLTDKEKAL
                     AIVKDSVGAIFVRVLEDAGVYKQTEQGQTAFMRFVEQVGILLD"
     gene            complement(14381..15559)
                     /locus_tag="VVO18_000671"
     CDS             complement(14381..15559)
                     /locus_tag="VVO18_000671"
                     /EC_number="2.7.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000047000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactokinase"
                     /protein_id="HEU5585871.1"
                     /translation="MTQHLTAETLRKDFLAVFGQEADQTFFSPGRINLIGEHTDYNGG
                     HVFPAAISLGTYGAARKRDDQVLRFYSANFEDKGIIEVPLADLKFEKEHNWTNYPKGV
                     LHFLQEAGHVIDKGFDFYVYGNIPNGAGLSSSASLELLTGVVAEHLFDLKLERLDLVK
                     IGKQTENNFIGVNSGIMDQFAIGMGADQRAIYLDTNTLEYDLVPLDLKDNVVVIMNTN
                     KRRELADSKYNERRAECEKAVEELQVALDIQTLGELDEWAVDQYSYLIKDENRLKRAR
                     HAVLENQRTLKAQAALQAGDLETFGRLMNASHVSLERDYEVTGLELDTLVHTAWAQEG
                     VLGARMTGAGFGGCAIALVQKDTVEAFKEAVGKHYEEVVGYAPSFYIAEVAGGTRVLD
                     "
     gene            15869..16597
                     /locus_tag="VVO18_000672"
     CDS             15869..16597
                     /locus_tag="VVO18_000672"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="substrate-binding domain-containing protein"
                     /protein_id="HEU5585872.1"
                     /translation="MDYDILRYFNDHPFTLSEEVIGILCIGKFSRAQISAFEEYQKPL
                     VFLDSDTLSLGHTCIITDFYTAMKQVVDYFLSQGMDRIGILTGLEETTDQEEIIEDKR
                     LENFRNYSQAKGIYHDELIFQGNFTAQSGYDLMKEAIQNLGDQLPPAFFAASDSLAIG
                     ALRALQEAGISLPDRVSLISFNDTSLTKQVYPPLSSITVYTEEMGRAGMDILNKEVLH
                     GRKIPSLTMLGTRLTLRESTLNQE"
     gene            complement(16643..17680)
                     /locus_tag="VVO18_000673"
     CDS             complement(16643..17680)
                     /locus_tag="VVO18_000673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000833740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic
                     domain-containing protein"
                     /protein_id="HEU5585873.1"
                     /translation="MKSAVYTKAGQVGLASIERPQIIEADDVIIRVVRACVCGSDLWR
                     YRNPETKAGHKNSGHEAIGIVEEAGEAITTVKPGDFVIVPFTHGCGECDACLAGFDGS
                     CDNHIGNNLGGDFQAEYIRFHYANWALVKIPGQPSDYTEGMLKSLLTLADVMPTGYHA
                     ARVANVQKGDKVVVIGDGAVGQCAVIAAKMRGASQIILMSRHEDRQKMAMESGATAVV
                     AERGQEGITKVREILGGGADAALECVGTEAAIEQALGVLHNGGRMGFVGVPHYNNRAL
                     GSTFMQNISVAGGAASATTYDKQFLLKAVLDGDINPGRVFTSSYKLEDIDQAYKDMDE
                     RKTIKSMIVIE"
     gene            complement(17681..18034)
                     /locus_tag="VVO18_000674"
     CDS             complement(17681..18034)
                     /locus_tag="VVO18_000674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MerR family transcriptional regulator"
                     /protein_id="HEU5585874.1"
                     /translation="MNIKSASDLLGISADTIRYYERVGLVPPITRTATGIRDFQDQDI
                     EALEFIKCFRSAGVSVDSLVDYMSLYQKGDETREERLGILEEEKQKLEERLSQLQTAL
                     NRLNLKIKLYKEGKF"
     gene            complement(18278..19168)
                     /locus_tag="VVO18_000675"
     CDS             complement(18278..19168)
                     /locus_tag="VVO18_000675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000645104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation transporter"
                     /protein_id="HEU5585875.1"
                     /translation="MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDV
                     IAIGISAFLETISNREEDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHP
                     QPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
                     RFTDWYILDPLLSLVISFFILSKALSRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNV
                     ASLNQLNLWTMDALEKNAIVHVCLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLE
                     THQTHKRKVCDLERSYEHQH"
     gene            19301..19837
                     /locus_tag="VVO18_000676"
     CDS             19301..19837
                     /locus_tag="VVO18_000676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866629.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="HEU5585876.1"
                     /translation="MTNIDRRISKTKKAIYQAFIQLLNAKGYEATTVQDIIDLADVGR
                     STFYCHYESKELLLDQLCRYLFHHLFEREQAISTEDYLAHLFLHFHKNQDHITSLLFS
                     KNDYFLRQLHKELEHHVYSVLADNLKEAHPNMPTSYLQHLVVSNFIETLTWWLKKGQD
                     FTDQEVVQFYLDLLIPKN"
     gene            complement(20003..20809)
                     /locus_tag="VVO18_000677"
     CDS             complement(20003..20809)
                     /locus_tag="VVO18_000677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="HEU5585877.1"
                     /translation="MHTYLQKKIENIKTTLGEMSGGYRRMVAAMADLGFSGTMKAIWD
                     DLFAHRSFAQWIYLLVLGSFPLWLELVYEHRIVDWIGMICSLTGIICVIFVSEGRASN
                     YLFGLINSVIYLILALQKGFYGEVLTTLYFTVMQPIGLLVWIYQAQFKKEKQEFVARK
                     LDGKGWTKYLSISVLWWLAFGFIYQSIGANRPYRDSITDATNGVGQILMTAVYREQWI
                     FWAATNVFSIYLWWGESLQIQGKYLIYLINSLVGWYQWSKAAKQNTDLLN"
     gene            complement(21154..22674)
                     /locus_tag="VVO18_000678"
     CDS             complement(21154..22674)
                     /locus_tag="VVO18_000678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521043.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease/substrate-binding
                     protein"
                     /protein_id="HEU5585878.1"
                     /translation="MTNLIATFQDRFGDWLTALSQHLQLSLLTLLLAILLAIPLAVYL
                     RYHEKLADWVLQIAGIFQTIPSLALLGLFIPLMGIGTLPALTALVIYAIFPILQNTIT
                     GLKGIDPSLQEAGIAFGMTRWERLKKFEIPLAMPVIMSGIRTAAVLIIGTATLATLIG
                     AGGLGSFILLGIDRNNASLILIGALSSAVLAIAFNFLLKVMEKAKLRTIFSGFALVAL
                     LLGLSYSPALLAQKEKENLIIAGKIGPEPEILANMYKLLIEENTSMTATVKPNFGTTS
                     FLYEALKKGDIDIYPEFTGTVTESLLQPSPKVSHEPEQVYQVARDGIAKQDHLAYLKP
                     MSYQNTYAVAVPKKIAQEYGLKTISDLKKVEGQLKAGFTLEFNDREDGNKGLQSMYGL
                     NLNVATMQPALRYQAIQSGDIQITDAYSTDAELERYDLQVLEDDKQLFPPYQGAPLMK
                     EALLKKHPELERVLNTLAGKITESQMSQLNYQVGVEGKSAKQVAKEFLQEQGLLKK"
     gene            complement(22667..23395)
                     /locus_tag="VVO18_000679"
     CDS             complement(22667..23395)
                     /locus_tag="VVO18_000679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5585879.1"
                     /translation="MIEYKNVALRYTEKDVLRDVNLQIENGEFMVLVGPSGSGKTTMI
                     KMINRLLEPTDGNIYMDGKRIKDYDERELRLTTGYVLQAIALFPNLTVAENIALIPEM
                     KGWSKEEITKKTEELLAKVGLPVAEYGHRLPSELSGGEQQRVGIVRAMIGQPKILLMD
                     EPFSALDAISRKQLQVLTKELHKEFGMTTIFVTHDTDEALKLADRIAVLQDGEIRQVS
                     NPETILKAPATDFVADLFGGSVHD"
     gene            complement(23410..24174)
                     /locus_tag="VVO18_000680"
     CDS             complement(23410..24174)
                     /locus_tag="VVO18_000680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000043863.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="HEU5585880.1"
                     /translation="MSQQVKNAHNLYIHAIQDGRVSEAQAQSVGDTYIQHSTGVPDGK
                     EGFAAFFADFFERHPERQIKIVRTIEDGNLVFVHVHQYLNGGEAQWVTTDTFRADENG
                     RIVEHWDVIDYYRTPENDQLDQIFGDFEIKDLDKKAENKKLVRRFLTEIFQNGELEQW
                     NDYVADDLIQHNHEIGQGSAAYKNYVAEYSVTFDFVFQLLGQGNYVVSYGQTQIDGVA
                     YAQYDIFRLENGKIVEHWDNKEVMPKVEDLTNRGKF"
     gene            complement(24178..24621)
                     /locus_tag="VVO18_000681"
     CDS             complement(24178..24621)
                     /locus_tag="VVO18_000681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000655204.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU5585881.1"
                     /translation="MKYCHLVAHHIRLLNGRIFQKLLRQDPDSLYRSEQGKILAVLWN
                     SETGCATATDIALATGLANNTLTTMIKNLEEQNLVTVSPCGEDKRKKYLVLTELGKSQ
                     KEVGQRVSQRLDTICYKGFSEEEIRQFEGFQERILANLKEKENEV"
     gene            complement(25303..25599)
                     /locus_tag="VVO18_000682"
     CDS             complement(25303..25599)
                     /locus_tag="VVO18_000682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230158.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
                     /protein_id="HEU5585882.1"
                     /translation="MVEPNLESLIKDLYNHARHDLSEDLVAALLETTKKLPTTNEQLQ
                     AVRLSGLVNRELLLNPKHPAPELLNLARFIKREEAKYRGTATSALMYEELFKML"
     gene            complement(25621..26685)
                     /gene="pepA"
                     /locus_tag="VVO18_000683"
     CDS             complement(25621..26685)
                     /gene="pepA"
                     /locus_tag="VVO18_000683"
                     /EC_number="3.4.11.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamyl aminopeptidase"
                     /protein_id="HEU5585883.1"
                     /translation="MTTLFSKIKEVTELAAVSGHEAPVRAYLREKLTPHVDEVVTDGL
                     GGIFGIKHSEAVDAPRVLVASHMDEVGFMVSEIKPDGTFRVVEIGGWNPMVVSSQRFK
                     LLTRDGHEIPVISGSVPPHLTRGKGGPTMPAIADIVFDGGFADKAEAESFGIRPGDTI
                     VPDSSAILTANEKNIISKAWDNRYGVLMVSELAEALSGQKLGNELYLGSNVQEEVGLR
                     GAHTSTTKFDPEVFLAVDCSPAGDVYGGQGKIGDGTLIRFYDPGHLLLPGMKDFLLTT
                     AEEAGIKYQYYCGKGGTDAGAAHLKNGGVPSTTIGVCARYIHSHQTLYAMDDFLEAQA
                     FLQALVKKLDRSTVDLIKHY"
     gene            27086..27805
                     /gene="galE"
                     /locus_tag="VVO18_000684"
     CDS             27086..27805
                     /gene="galE"
                     /locus_tag="VVO18_000684"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167854.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEU5585884.1"
                     /translation="MTKTILVTGGTSYIGSHTVKALLNAGYKVHVLDNLSTGNRAAVD
                     SRASFKELDVYDASALKAYLEENQIDAVLHCAGEIVVSESIENPSKYFTANVAGRNQV
                     LKVLSEVGIQKIMFSSTASLYGNNCIDKPVTEDTLLDPVNPYAETKLMGERMIYWMAN
                     RYDWKYVIFRYFNVAGAEMDASNGLRVKNPTHIIPNINKTALGQNDSLKIFGDDYDTH
                     DGSCIRDYIYVLDLHRLMLKE"
     gene            28209..29168
                     /locus_tag="VVO18_000685"
     CDS             28209..29168
                     /locus_tag="VVO18_000685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5585885.1"
                     /translation="MKLSYYLIGLLLLLVFLSISIGTSDFSWGKLFDFDQQTWLLFQE
                     SRLPRTISILLTASSMSMAGLLMQTITQNQFAAPSTVGTTEAAKLGMVLSLFVFPSAS
                     LTQKMLFAFVSSIVFTLFFLAFMTIFTVKERWMLPLIGIIYSGIIGSVTEVIAYRFNL
                     VQSMTAWTQGSFSMIQTHQYEWLFLGLIILITVWKLSQTFTIMNLGKETSESLGISYS
                     LLEKLALFLVALTTSVTMITVGGLPFLGVIVPNLVRKCYGDNLSQTKLMVALVGANLV
                     LACDILSRVLIRPYELSVSLLLGIIGSLVFILLLWRGGRKDAD"
     gene            29158..30114
                     /locus_tag="VVO18_000686"
     CDS             29158..30114
                     /locus_tag="VVO18_000686"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="HEU5585886.1"
                     /translation="MQTKSKHTKLFWILIILAIGACLLYFWPITHLSAFAWKLRSQKI
                     IVYLLVAIATGISTISFQTLTENRFLTPSILGIESFYVLLQTLLLVFESKFLQLGKSP
                     ILEFLVLLLVQSLFFLALQGYLKTLMKQDLVFILLICLALRSLFRNISTFLQVLMDPN
                     EYDKLQNSLFASFQHLNTSILAIGSLIILALTIFFFRKAVVLDVLHLQRETAQILGLD
                     VEKEQKELLWGIVLLTSTATALVGPMAFFGFILANLTYLIVKDYQHKLLFIVAILVGF
                     ISLTLGQALIERVFALEIRISMIIESVGGFLFFILLYRRSRQ"
     gene            30111..30863
                     /locus_tag="VVO18_000687"
     CDS             30111..30863
                     /locus_tag="VVO18_000687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5585887.1"
                     /translation="MKLENIDKSIQKQDILQGISLEVSPQKLTAFIGPNGAGKSTLLS
                     IMSRLTKKDQGVLSIKGREIESWNSQELAQELTILKQKINYQAKLTVEELVSFGRFPY
                     SRGRLRSEDWEKIRETLNYLELTNLKDRYINSLSGGQLQRVFIAMVLAQDTDFILLDE
                     PLNNLDIKQSVSMMQILRRLVEELGKTIIIVLHDINMASQYADEIVAFKDGQVFSKGR
                     TDQIMQADLLSQLYEIPITLADINDKKICIYS"
     gene            30959..31924
                     /locus_tag="VVO18_000688"
     CDS             30959..31924
                     /locus_tag="VVO18_000688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858258.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="siderophore ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5585888.1"
                     /translation="MKTSLKLYFTALVASFLLLLGACSTNSSTSQTETSSSAPTEVTI
                     KSSLDEVKLSKVPEKIVTFDLGAADTIRALGFAKNIVGMPTKTVPTYLKDLVGTVKNV
                     GSMKEPDLEAIAALEPDLIIASPRTQKFVDKFKEIAPTVLFQASKDDYWTSTKANIES
                     LASAFGETGTQKAKEELAKLDKSIQEVATKNESSDKKALAILLNEGKMAAFGAKSRFS
                     FLYQTLKFKPTDTKFEDSRHGQEVSFESVKEINPDILFVINRTLAIGGDNSSNDGVLE
                     NALIAETPAAKNGKIIQLTPDLWYLSGGGLESTKLMIEDIQKALK"
     gene            complement(32149..32391)
                     /gene="yidD"
                     /locus_tag="VVO18_000689"
     CDS             complement(32149..32391)
                     /gene="yidD"
                     /locus_tag="VVO18_000689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="HEU5585889.1"
                     /translation="MKRILIALVRFYQRFISPVFPPSCRFELTCSNYMIQAIEKHGFK
                     GVLMGLARILRCHPWSKTGKDPVPDHFSLKRNQEGE"
     gene            complement(32391..33113)
                     /locus_tag="VVO18_000690"
     CDS             complement(32391..33113)
                     /locus_tag="VVO18_000690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150169.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEU5585890.1"
                     /translation="MRINKYIAHAGVASRRKAEELIKQGLVTVNGQVVRELATTIKSG
                     DKVEVEGQPIYNEEKVYYLLNKPRGVISSVTDDKGRKTVVDLLPNVKERIYPVGRLDW
                     DTSGVLILTNDGDFTDEMIHPRNEIDKVYVARVKGVANKDNLRPLTRGLEIDGKKTKP
                     AVYEILKVDPVKNRSVVQLTIHEGRNHQVKKMFEAVGLQVDKLSRTRFGHLDLTGLRP
                     GESRRLNKKEISQLHTMAVTKK"
     gene            complement(33100..33669)
                     /locus_tag="VVO18_000691"
     CDS             complement(33100..33669)
                     /locus_tag="VVO18_000691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105309.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein B"
                     /protein_id="HEU5585891.1"
                     /translation="MSTLAKIEALLFVAGEDGIRVRQLAELLSLPPTGIQQSLGKLAQ
                     KYEKDPDSSLALIETSGAYRLVTKPQFAEILKEYSKAPINQSLSRAALETLSIIAYKQ
                     PITRIEIDAIRGVNSSGALAKLQAFDLIKEDGKKEVLGRPNLYVTTDYFLDYMGINHL
                     EELPVIDELEIQAQESQLFGERIEEDENQ"
     gene            complement(33688..34416)
                     /locus_tag="VVO18_000692"
     CDS             complement(33688..34416)
                     /locus_tag="VVO18_000692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000351912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="segregation/condensation protein A"
                     /protein_id="HEU5585892.1"
                     /translation="MDIKLKDFEGPLDLLLHLVSKYQMDIYDVPITEVIEQYLAYVST
                     LQAMRLEVTGEYMVMASQLMLIKSRKLLPKVAEVTDLGDDLEQDLLSQIEEYRKFKLL
                     GEHLESKHQERAQYYSKAPTELIYEDAELVHDKTTIDLFLAFSNILAKKKEEFAQNHT
                     TILRDEYKIEDMMIIVKESLIGRDQLRLQDLFKEAQNVQEVITLFLATLELIKTQELI
                     LVQEESFGDIYLMEKKEESQVPQS"
     gene            complement(34416..35156)
                     /gene="xerD"
                     /locus_tag="VVO18_000693"
     CDS             complement(34416..35156)
                     /gene="xerD"
                     /locus_tag="VVO18_000693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-specific tyrosine recombinase XerD"
                     /protein_id="HEU5585893.1"
                     /translation="MPMRDRISAFLEEKQGLSVNSKQSYKYDLEQFLDMVGERISETS
                     LKIYQAQLANLKISAQKRKISSCNQFLYFLYQKGEVDSFYRLELAKQAEKKTEKPEIL
                     YLDSFWQESDHPEGRLLALLILEMGLLPSEILAIKVADINLDFQVLRISKASQQRIVT
                     IPTALLSELEPLMGQTYLFERGEKPYSRQWAFRQLESFVKEKGFPSLSAQVLREQFIL
                     RQIENKVDLYEIAKKLGLKTVLTLEKYR"
     gene            complement(35147..35608)
                     /locus_tag="VVO18_000694"
     CDS             complement(35147..35608)
                     /locus_tag="VVO18_000694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000560721.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU5585894.1"
                     /translation="MIAKEFETFLLGQEETFLTPAKNLAVLIDTHNADHATLLLSQMT
                     YTRVPVVTDEKQFVGTIGLRDIMAYQMEHDLSQEIMADTDIVHMTKTDVAVVSPDFTI
                     TEVLHKLVDESFLPVVDSEGIFQGIITRKSILKAVNALLHDFSKEYEIRCQ"
     gene            complement(35605..36126)
                     /locus_tag="VVO18_000695"
     CDS             complement(35605..36126)
                     /locus_tag="VVO18_000695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001118598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metallophosphoesterase"
                     /protein_id="HEU5585895.1"
                     /translation="MAKQTIIVMSDSHGDSLIVEEVRDRYVGKVDAVFHNGDSELRPD
                     SPLWEGIRVVKGNMDFYAGYPERLVTELGSTKIIQTHGHLFDINFNFQKLDYWAQEEE
                     AAICLYGHLHVPSAWMEGKILFLNPGSISQPRGTIRECLYARVEIDDSYFKVDFLTRD
                     HEVYPGLSKEFSR"
     gene            complement(36102..37073)
                     /locus_tag="VVO18_000696"
     CDS             complement(36102..37073)
                     /locus_tag="VVO18_000696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000182414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside-triphosphate diphosphatase"
                     /protein_id="HEU5585896.1"
                     /translation="MTNKIYEYKDDQDWYVGSYSIFGGVNSLSDYKTDFPLFEFSKIF
                     GDEEYGFPLSVTVLRYGSTYRLFSFVVDMLNQEMGRNLEVIQRHGALLLVENGQLLYV
                     ELPKEGVNVHDFFETSKVRETLLIATRNEGKTKEFRAIFDKLGYDVENLNDYPDLPEV
                     AETGMTFEENARLKAETISQLTGKMVLADDSGLKVDVLGGLPGVWSARFAGVGATDRE
                     NNAKLLHELAMVFELKDRSAQFHTTLVVASPNKESLVVEADWSGYINFEPKGENGFGY
                     DPLFLVGETGESSAELTLEEKNSQSHRALAVKKLLEVFPSWQSKPSL"
     gene            complement(37070..37864)
                     /gene="racE"
                     /locus_tag="VVO18_000697"
     CDS             complement(37070..37864)
                     /gene="racE"
                     /locus_tag="VVO18_000697"
                     /EC_number="5.1.1.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370386.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate racemase"
                     /protein_id="HEU5585897.1"
                     /translation="MDNRPIGFLDSGVGGLTVVRELMRQLPHEEIVYIGDSARAPYGP
                     RPAEQIREYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKAQLDIPVLGVILPGASA
                     AIKSSQGGKIGVIGTPMTVQSDIYRQKIHDLDPDLQVESLACPKFAPLVESGALSTSV
                     TKKVVYETLRPLVGKVDSLILGCTHYPLLRPIIQNVMGPKVQLIDSGAECVRDISVLL
                     NYFEINRGRDAGPLHHRFYTTASSQSFAQIGEEWLEKEIHVEHVEL"
     gene            complement(38071..38319)
                     /locus_tag="VVO18_000698"
     CDS             complement(38071..38319)
                     /locus_tag="VVO18_000698"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000364981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YneF family protein"
                     /protein_id="HEU5585898.1"
                     /translation="MDLLLAIVLIVLAFLGGALGGMYLVRKQIEKEFADNPRLNAEAV
                     RTLLSANGQKPSEAKVQQVYHQIIRQQKAALANNKKKK"
     gene            complement(38575..40200)
                     /gene="treC"
                     /locus_tag="VVO18_000699"
     CDS             complement(38575..40200)
                     /gene="treC"
                     /locus_tag="VVO18_000699"
                     /EC_number="3.2.1.93"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="HEU5585899.1"
                     /translation="MTLDKGKVVYQIYPKSYKDTTENGIGDFRGIIEKIPYLAKLGVD
                     MVWLNPFYPSPQRDNGYDISDYMAVDPLFGDMADFEEMVCVGKEHKIDFMLDMVLNHC
                     STEHEWFQKALAGDKYYQDFFFIQDQPTDWQSKFGGSAWTPFGDTGKYYLHLFDETQA
                     DLNWRNSNVRKELFKVVNFWRDKGIKGFRFDVINLIGKDEVSVDCPENEGKPAYTDKP
                     IVHNYLRMMNQATFGSDDSFMTVGEMSSTTMENCVLYSSPDRQELSMTFNFHHLKVDY
                     KDGQKWTLAPFDFEELKSLYHSWGKEMSDKDGWSALFWNNHDQPRALNRFVDIQNFRK
                     EGATMLAASIHLSRGTPYIYMGEEIGMIDPDYDSMADYVDVESLNAYQMLLEEGKSQQ
                     EAFQIIQAKSRDNSRIPMQWDASENAGFSTGTPWLKAGKSYKDINVENEIQGPIFTFY
                     QDLIRLRKEMPIISEGSYKPAFEDSKQVYAFERQFEDQKLLVLNNFYAKEVEIDLPAV
                     YQNGQILISNYEDAEVSEKILLKPYQTLAIYVN"
     gene            complement(40378..42345)
                     /gene="treP"
                     /locus_tag="VVO18_000700"
     CDS             complement(40378..42345)
                     /gene="treP"
                     /locus_tag="VVO18_000700"
                     /EC_number="2.7.1.201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864201.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="HEU5585900.1"
                     /translation="MGKFEQEAKDLLQAIGGKENVTAVTHCATRMRFVLGDDKKANVK
                     AIESIPAVKGTFTNAGQFQVIIGNDVPIFYNDFTAVSGIEGVSKEAAKSAAKSNQNVV
                     QRVMTTLAEIFTPIIPALIVGGLILGFRNVLEGVHWSMLDGKTITESSQFWAGVNHFL
                     WLPGEAIFQFLPVGITWSVSRKMGTSQILGIVLGICLVSPQLLNAYAVASTPAADIAA
                     NWVWNFGYFTVNRIGYQAQVIPALLAGLSLSYLEIFWRKHIPEVISMIFVPFLSLIPA
                     LILAHTVLGPIGWTIGQGLSSVVLAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAI
                     DTQLIADAGGTALWPMIALSNIAQGSAVFAYYFMHRHDEREAQVSLPATISAYLGVTE
                     PALFGVNVKYIYPFVAGMTGSALAGMLSVTFNVTAASIGIGGLPGILSIQPQYMLPFA
                     GTMLVAIVVPMLLTFFFRKAGLFTKTEGDTNLQAEFVAQEEAEFVNHEPVELTSVEII
                     SPLTGQVKELSQATDPIFASGVMGQGLVIEPSQGELTSPVNGTVTVLFPTKHAIGIVS
                     DEGVELLIHIGMDTVGLDGKGFESLVVQGDHVTVGQQLIRFDMDVIKAAGLVTETPVI
                     ITNQDAYTATIPGTYPTTIQAGASLMVATRI"
     gene            42530..43240
                     /gene="treR"
                     /locus_tag="VVO18_000701"
     CDS             42530..43240
                     /gene="treR"
                     /locus_tag="VVO18_000701"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trehalose operon repressor"
                     /protein_id="HEU5585901.1"
                     /translation="MKKYQQLFKQIQETIQNETYAVGDFLPSEHDLMEQYQVSRDTVR
                     KALSLLQEEGLIKKIRGQGSQVVKEETVNFPVSNLTSYQELVKELGLRSKTNVVSLDK
                     IIIDKKSSLITGFPEFRMVWKVVRQRVVDDLVSVLDTDYLDMELIPNLTRQIAEQSIY
                     SYIENGLKLLIDYAQKEITIDHSSDRDKILMDIGKDPYVVSIKSKVYLQDGRQFQFTE
                     SRHKLEKFRFVDFAKRKK"
BASE COUNT        12652 a         9992 c         8308 g        12439 t
ORIGIN      
        1 gctagaaatt aatttgacta tcctgattga tttgtcctgt ttttatttca ttttactata
       61 ggactttcaa ttgaaaacaa cagttttaca ctcaattaga ctttttagaa acagaatcac
      121 tattacttga ctgtagtttg tcattttttt gatgaagtta gcactttttc agaaactgtt
      181 ttgaaagtct caatgatata gtccacttct tcatcactta atttagtgtg aagaggaagg
      241 gtaatttcat tttcaaagaa ggcataggcc ttaggatagt tcgccatgtc aaaaccaaga
      301 ttcttatagg ctgtcaagag cggaagcggt ttgtagtgta cgttacttgc aattcctgcc
      361 ttggccaatt cttggatgat aagattgcgt tcttctaagc ttgctccttc tacatgggta
      421 atgtagaggt gacgtgaaga ttcgacagtt tcagtcttgt gtgctaaagg atggatgcga
      481 gaacctgcaa aaccacgatc atagcggtcc acaatgtcct tacgacgttg caacaaacca
      541 gagtaacggt ccaattgcac caaaccaagc gaagccatga tatcggtcat attgcacttg
      601 taggctggtg tgacgatatc gtattcccat gaacccagtt gcatcttagc aagagcatcc
      661 ttagtttgcc cgtgaaggga aagaatttgg aattctttgt acatctcttc gtcgtcaatc
      721 gctggattgg ctttccaagt cgcacttcca ccttctgctg ttgtaaagtt cttaacggca
      781 tggaatgaga aggaagtaaa gtcagcgata gaaccagctg gttgtccttt ataagtagat
      841 cccaaagcat gggcactatc agaaacaatc acgatacggt taaaggcttt ttgccacttg
      901 cttgaagcag taaagaggtc acgtttcttc tccactactt ggaacaaacg gtcatagtcg
      961 caaacaatcc ctgcaagttc tactggaatg attaccttgg tcttttcagt gatagcttgc
     1021 tccagcaagt cataatccat ctcaaacgta tctgcttgga tatccaccat gacaggtgtt
     1081 gctcctacgt gagtgatgac actacatgaa gctgtatagg tcatagctgg aacgacgact
     1141 tcatcaccag gccccacttc caagacgcgc aaaatcaact caagagcggc agtcgcagag
     1201 tttaggcaga cagtcttggg tgtctgtgtg tattgagaca agcgacgctc caattctttt
     1261 gtcttaggac cggttgtgat ccaaccagaa cgaagggtat ccgctacttc agcaatttct
     1321 gcttctgtaa tatcgggtgg tgaaaatgga atattgtaat ttggcattga tttgctcctt
     1381 ttatctgtac tcattttctc atgactactt tattttagca cttcaaacac ggtttgaaac
     1441 atgattttga tgtctccaag gaaactaaac tctcggagat aggctaggtt atagcgcatc
     1501 ttttcaggta gaacgtattc gacataggct tggtcaaccg acagaccttt ctccgtcatt
     1561 tgactgatga tagtgtcctc atccttgtag tgaatgctgg ctggagaggt aatccctgct
     1621 ggcaagagca aggtcgccat catttcaggg ctatactgct ctgtgtaacg aggcacttca
     1681 ggacgcgtcc ctacaaaaga catctcgcct ttaaggacat tgaccaactg aggcagttcg
     1741 tccaaacgca cacggcggat gaaattacca accttggtaa tgcggctatc gttagcagaa
     1801 gtcactagac ttcctttttt atccgcatcc gtcaccatgg tacggaactt ccaaatcttg
     1861 aaccgacggt tgtactgggt cacgcgctct tgcttgtaaa tcactggccc cttgctatcc
     1921 aacttgatcc aaatgctcat gatgagaaag atgggagagg tcagaaccag tacaaccaag
     1981 gccaaaaccc agtccaaaca acgcttgaaa atcagcgaac ccttcctttt agagacaagc
     2041 tggtagtaag actcaacctc gcttgatttc atttccacgg gcaagtcttc ccatttcagc
     2101 atgctgtttc tcctttgttt ttattatact atttgtcaac atttttcatt ataccacaaa
     2161 atggaaaagg cggtgaaaga aatctgtaat ttgaaggatt tccttcttac actcaatgaa
     2221 aatcaaagta cagcttttag gttgcagata aagctgacat ggcttgaata gattttcaaa
     2281 gagtattaag acatggctcc tgcctgcaag ctatacatct tgtgataggt tcctcccaag
     2341 gccaaaagtt cctcatgggt tccgctctcg ataatgcgcc ccttgtccaa aacatagata
     2401 cagttggcgt cttggatggt agagagacga tgggcgatag caatggttgt ccgtccctgt
     2461 ctcatcttag ccagagaagc ctgaaccaga ctttctgttt cagagtcaat attggctgtc
     2521 gcttcatcca aaatcaggat tttaggctgg ctggcgactg ttctggcaaa ggcaagaagt
     2581 tgacgctgac ctgttgaaaa actggagcca cgctcggaaa caggggaatc ataaccctga
     2641 ggaagttctt gaataaagga atctgcatcc acgaaggctg ctgcagcccg gacctgctca
     2701 tcactgattt cttggtacat ggcgatattg gacttaatag ttccgtgata gaggaaggga
     2761 tcctgcaaga ccagaccgat atttgttctc agctcttcct gactgtaggc cctaatatcc
     2821 acactatcca agagaactcg ccctgactga aattcataaa agcgcatgag gacattgata
     2881 atcgaagatt tccctgaacc tgtatgaccc acaaaggcaa tggtttcacc cttattaacg
     2941 gagaaggaaa tgtcatccag aatcggatgt tttccatcat aagagaaaca tacatgttca
     3001 aaacggatat tgccttcttt gatcacggcc tgtccatttt cttgaagagg ctcataggtt
     3061 ctctcgtcaa tcagagcaaa gacacggcct gcagaaacca tggaagtttg aagggttgaa
     3121 aagttttgcg tcacctcaat caaagggtca aagaggcggt taatgtactg aataaaggca
     3181 tacatagtcc cggcagttat cccgatagaa aaaccacggt agccaaagta ggccatcaag
     3241 actgcatagc ctagaagttt cagcaaactc atagcagggc gcaaaaagag ggcatccaag
     3301 gctacagaac ggttggcata gaccaagtgc tcttggttga tttcatcaaa ttctgcctgc
     3361 aggcgcttct cctgattaaa ggcctggatt attctgattc cctcgatgtt ttcagccagc
     3421 ttactattga tatctgataa gagacttctg gttttttcga taatcttgac ggattttttc
     3481 cgatagagat tgaccaaaag gaaaatcaag ggaagaaaga tcaagactaa agtcgtcaaa
     3541 cgaaaatcca acaccaacat ggtataaagg gttgtcagaa agatgaaaac tgctgagata
     3601 aagctggaca aaatccccga aaacatatca ctgatggtct cggtatcatt tgtcaaacga
     3661 gagacgatag agcctgctgg cgtcttgtca aaataggaca tgcccaattt ctccatatta
     3721 gcaaaggcat cccgacgaat atccctaaca atactgtagg acacccgtgc aaagagaaga
     3781 ttaccgacat actgtaccat agtttgtagg atataaaggc catagtagac cagcaaaacg
     3841 gtcacagcga gttggttgag attactcaga tactggtcaa taaagtggga agccacaagg
     3901 ggaatgacac ttttgatgac cgtcgtcgct aggagaaaac tgagtgccaa aaaagtcagg
     3961 agtccataag gcttgagata agacatcaag cgcttcaata cagcccattg ttctttctta
     4021 ttctgcatct tcttctccct tcatttccag ttgctgagac tggtaggttt gggcatacca
     4081 gccatccaaa gctagcaagt catcgtgtgt acctcgttcg atgatttgac cattttgcag
     4141 gactaaaatc aaatctgcat gtacaactgc actgaggcga tgagccgtga taatggttgt
     4201 cttgtcctta cgtgtttcct taagattgtc gataatcgca tactctgtct tggcatccac
     4261 ggccgacaaa gaatcatcca aaatcaagat atcagggtct aaaatcatag cccgactcat
     4321 ggccagacgc tgcttttgac ctccagaaag actgactcct ttttctccaa tcagcgtatc
     4381 aaatccctga ggcatggcta caatatcttg gtaaacttgg gctagcttag ttgcttcctc
     4441 gactgctgaa aggggcaagt taggattgcc aaagcgaata ttgtctaaaa tcgaagtcgc
     4501 aaagaggaac tgatcctgag gaacatagcc cataagacta cgaagatctg tcagacgata
     4561 gtcacgaata tcgtgaccat ttagataaat ggttcccttg tccacatcgt attcacgcaa
     4621 gaggagcttg atcaaagatg ttttcccaga gcctgtttgc ccaaccaagc ccagggtttg
     4681 acctttttcc aaactaaagt gaacatttgt cagtgtttcc tcattttcaa aggcaaagct
     4741 gtcaatggta tactccaaac gcccattttc aataccatcc agaggaaact cagggtcttg
     4801 tacaggagat tcctgagaca aaagattttc aatccgctgg taagaaacct tccctcgctg
     4861 agtagtatta aagaggaagc cgatggccat aagaggccag accagcatat ccaaatagct
     4921 gataaaggtg actagattcc caactgtaat ctgcccttcc tgaaccatca aggagccaac
     4981 caaaagcgtt aaaacatagg acgaaccaac aaacacgaga accatagggt caaagagact
     5041 atcatatttc atggtttgca ggttcttttg gaaggttaat tcattgactg cctgaaaaga
     5101 cttcaactcg tctgcctgat aaccgaaaga cttggtcact ttgatacctg atacggactc
     5161 ctgtaccttg ttattgagtt cagaaaaagc agcttgggat tcgccaaagg ccttatgagt
     5221 ctttctccct aggcgactag ttgcataggc catgaaaggt agggggagaa tggcaacaag
     5281 agtcatctgc catgagatgc taaagagcat ggtcaacaaa gtcaccagag ccgtgataga
     5341 ggcatccacc gcagacatga caccgccacc tgctaaacga gtcaaggcat tgatatcatt
     5401 ggttgcgtgt gccatcagat cacccgtccg ataggtttga taaaaggctg atgacatttt
     5461 tgtgaaatgc ttaaacaagc gagaccgcat gatctgtccc aagcaataag aggtcccaag
     5521 gatatacata cgccacacat agcgcaaata gtacatacca aaggctgcaa gtagcaagta
     5581 aaataggcta agaaggaggt cctgctgggt taattgcccc gatgtgatgg catcaatgac
     5641 ccgccccata accataggag gaatgagatt gaggacggaa accaagacca aggccacaat
     5701 cccgactaga taacggcgtt tttctaactt gaaaaaccac cagagttttt gaataatgga
     5761 cataaaatcc ctttctgatc gcaaatggaa acctgaggcc aatactcaat gaaaatcaaa
     5821 gagcaaacta ggaaactagc cgcaggctgc tcaaagcact gctttgaggt tgtagataga
     5881 actgacgaag tcagtaacct acatacggca aggcgacgtt gacgcggttt gaagagattt
     5941 tcgaagagta caagacccca ggtttttctt attcataagt tacgactgta acagcaccct
     6001 tgtcatattc agcaataaag atattggcta cattgtcatg cccttgtttg ctgaggttat
     6061 caagcaacca ctcttcgcta cgaccaatcg attccaagac atctacttga atcacaccgt
     6121 cagtcacaac tggatactta ggattttcat ctcccatttg cacaacgatg agttgcccat
     6181 tttgctcttg cacagctcgt ttgacttgct tcatctggaa aatcccttgg ctacgaagtt
     6241 tgagggctac atccgatgca gacaaaccaa ctgaacgaca ggcttatggg tcaatattcc
     6301 catttttgat aaggagagtt ggcttaccat caatcaaacg tttcacaaag tgaacattgt
     6361 tgttgagcta tttgagagtc aagaccagtt tgattaaaat ttcgatataa ttaagtgtca
     6421 tttgttcaca tccaccagtt caattgcgtc tgtcttatac aattcgactt tctctaacag
     6481 gtacttgtct ggctcacttc cgtttagggc acgataatag cgatctccca ccttgataag
     6541 tgcgccatct gtgtttgtgg aagtattaac atagacttct gacttgtcta ctcccaaatc
     6601 tttggaaaca acctcgatga aatgaagtga agtttgaaat ttattgttag aaacttgatt
     6661 gttttgataa gtcgtgatgc tgaccaaaag cagagctaaa taaggccaga gctgaaatca
     6721 tgaccaactc acgaaattcg gttccctttt tatcatggta tgccttaaaa gcaaaaaaac
     6781 tgtcacagct aatagaacaa tcccaaagcc aaccatgata ccattttgct gaccgatttg
     6841 gctgagtaca tagtcataag agtagaattt catgtatttt cactcccttt cataaaatca
     6901 ttcttaatta taaacgaaag agagtaattt ttcaaactat acgttgggga aatagatctt
     6961 tttttggtat aataaaatct ataatctgaa tgaaaaaggt aactttatga aacttatctc
     7021 atggaatatt gattccctaa acgctgccct aactagtgac tcagctcgtg ccaaattgtc
     7081 ccaagaagtc ctacaaacct tggtcgctga aaatgctgat atcattgcta tccaagaaac
     7141 caagctttct gccaaaggac ctacaaagaa acacgtggaa attttagaag aactcttccc
     7201 aggctacgaa aacacgtggc gctcttccca agagcctgcc cgtaaaggct atgctggaac
     7261 catgttcctt tataagaaag aacttacacc cactgtcact ttcccagaaa tcggtgcccc
     7321 ttctaccatg gacttggaag gccgcatcat cactctagaa tttgatgcat ttttcgtgac
     7381 ccaagtttac actccaaatg ctggcgatgg tcttaaacgc ttggaagaac gccaagtctg
     7441 ggatgtcaaa tatgcggagt atttggctga actagacaaa gaaaaaccag tccttgcgac
     7501 cggtgactac aacgtagccc acaatgaaat cgaccttgca aatcctgcta gcaaccgccg
     7561 ttcacctgga tttactgacg aggaacgtgc tggatttacc aaccttttgg caactggatt
     7621 tacagacacc ttccgccatg ttcatggcga tgttcctgaa cgctacactt ggtgggcaca
     7681 acgcagcaaa acttctaaaa tcaacaatac aggctggaga atcgactact ggctcacaag
     7741 taaccgtatc gctgacaagg tcactaaatc tgatatgatt gactcaggtg ctcgccaaga
     7801 ccatacaccg attgtcttgg aaattgactt gtaagaattt tctatatgga ctacaatgcg
     7861 gtcattcccg agttgcttgt atcgaatatc gaacagtccc ggtccttcta ctgtggttta
     7921 ctgggtttta ggattgaata ccaacgtcca gaagaaaact ttctctttct ttctcttgaa
     7981 gagtgtcaac taatgttaga ggagggaaca aaggatcaac tagctgaact gacctatcca
     8041 tttggtcgtg gagtcaatct ctcctttggc ataaaggatg tttcaaaact ctattaaaga
     8101 gtgatgaagg caaactatcc tatttatcgc cccttgacca aaagaaagtt tcgtgtcagt
     8161 gatccctata tctatcctca taaatttgca gttttggatc caaatggcta ttttttaaga
     8221 tttagcgagt agaataataa aaattgggaa aagtctttaa agttagaaaa aggcatattg
     8281 tcaggtgttt aaaaacttga tagtatgcct tttatgatgg aaaaatcttc taatactctt
     8341 cgaaaatctc ttcaagccac gtcaacgtcg ccttaccgta ggtatatgat actgactctg
     8401 tcaattctat ccacaacctc aaaacagtgt tttgaggttg tggatagctt cctagtttgc
     8461 tctttgattt tcatttagta taaatattag cttacaatgg agtttttgtt caccctctct
     8521 tctgtttgtt cgttttttaa accaaaacac taacaaaata gttgatttat aaagttattt
     8581 agtataaaat aaaaacattg gctcaagcct atttaaaatt gaatatcgtt ttacttgttt
     8641 atgtcgtgaa ttggcacgac gtttctacaa ggtgccggaa cacctaacaa taagtaagtc
     8701 agcagtgaga tatggccgtt tttgccatgc ctatttgggg gacttactta gagattaagt
     8761 aggtcttttt tgaatatttt taatatttcc cttaattagt gcggacggga ggtgaaatta
     8821 tcctgtgaat aatttcagga atccagggaa tttcatccct aatttttgag cccctagctc
     8881 tttcatttct aggcttaggc taaaatagtt ccccgaacta ttttactctc aaaaatcccg
     8941 tcatagacaa taacaagatc attgtctatg ataccactac aacgggaaat atttgataag
     9001 actattacga gcgaagcgag tcttatcaaa tatatagtat tagcaaaagg gatcactata
     9061 gaaacatttc aacaacaagt aaattagctt ttagacttta ggaggtctta tgaaattatt
     9121 agaagatcgc atcctcaagg atgggcatat cttgggtgat aacatcctca aggtagattc
     9181 ctttttaacc caccaagttg actttagctt gatgcgagag attggtaagg tttttgcgga
     9241 aaaatttgct gctgccggca ttaccaaggt cgtaaccatt gaagcgtcgg gtattgcccc
     9301 agccgttttt acagctgaag ccttaaacgt tcccatgatt ttcgccaaaa aagctaagaa
     9361 catcaccatg aacgaaggca tcttaactgc tcaagtctac tcctttacca agcaggtgac
     9421 cagcaccgtt tctatcgctg gaaaattcct ctcaccagag gacaaggttt tgattatcga
     9481 cgatttcctt gctaatggcc aagctgctaa aggcttgatt caaatcatcg aacaggccgg
     9541 tgccacagtc caagctatcg gtatcgtgat tgagaaatcc ttccaagatg gtcgtgattt
     9601 gcttgaaaaa gcaggctacc ctgtcctatc acttgctcgc ttggatcgtt ttgaaaatgg
     9661 tcaggtcgta tttaaggagg cagatctcta atgcaaactc aagaaaaaca ctcgcaagca
     9721 gccgttcttg gcttgcagca cttactagcc atgtactcag gatctatcct ggttcccatc
     9781 atgattgcga cagcccttgg ctattcagct gagcagttga cctacctgat ttctacagat
     9841 atcttcatgt gtggggtggc aaccttcctc caactccaac tcaacaaata ctttgggatt
     9901 ggactcccag tcgttcttgg agttgcattc cagtcggtcg ctcccttgat tatgattggg
     9961 caaagccatg gtagtggcgc tatgtttggt gcccttatcg catctgggat ttacgtggtt
    10021 cttgtttcag gcatcttctc aaaagtagcc aatctcttcc catctatcgt aacaggatct
    10081 gttattacca cgattggttt aaccttgatc cctgtcgcta ttggaaatat gggaaataac
    10141 gttccagagc caactggtca aagtctcttg cttgcagcta ttactgttct gattatcctc
    10201 ttgatcaaca tctttaccaa aggatttatc aagtctatct ctattttgat tggtctggtt
    10261 gttggaactg ccattgctgc tactatgggc ttggtggact tctctcctgt tgcggtagct
    10321 ccacttgtcc atgtcccaat tccactctac tttgggatgc caacctttga aatctcatct
    10381 attgtcatga tgtgtatcat cgcaacggtg tctatggttg agtcaactgg tgtttatcta
    10441 gccttgtctg atatcacaaa agatccaatc gacagcacgc gccttcgcaa cggttaccgc
    10501 gcagaaggtt tggccgtact tctcggagga atctttaaca ccttccctta caccggattt
    10561 tcacaaaacg ttggtttggt taaattgtca ggcatcaaaa aacgcctgcc aatctactac
    10621 gcagctggtt tcctggttct ccttggactg cttcctaagt ttggtgccct tgcccaaatc
    10681 attccaagct ccgtcctcgg cggtgccatg ctggtgatgt ttggttttgt atctattcaa
    10741 gggatgcaaa tcctagcccg agttgacttt gctaacaatg aacacaactt ccttatcgca
    10801 gctgtttcaa tcgctgcagg tgtcggtctc aacaacagta atctctttgt cagcatgccg
    10861 acagccttcc aaatgttctt ctcaaacgga atcgtcgtag ccagcctact cgccattgtc
    10921 ctcaatgccg tattaaatca taaaaagaaa taagaaaaag aggtgcgagc ctcttttttg
    10981 tgtgacaaaa taaaaacatc tacctattca tatatgctag tgtcatagtc ctgaaaatca
    11041 tctgcatcaa gaacaatttc acaactctta tacttttctc ttacaagtcg ttcggcttca
    11101 tctggatttt cagcctctat acttactaaa cgtgataaag tttctgtaat ttctactgta
    11161 tactttttca gttttagatt gctttccaat aattcaccta ttaacaataa tctatgatag
    11221 gagctatgta gccactctgg caatttatct cctacttccc acccatattt ttccttcatc
    11281 aaagctagtt gtttttcgtc accaaatttc atattttcag ataaccatct cacacaatcg
    11341 ggatctgata aggtacagac gattaaactt aggttatcgt aacggctttc agtttcataa
    11401 tcaggccaga tgacttttaa gaaatcatac acctcttctg atgcaacaag ttgtttcgtt
    11461 ttcataattt ccgatacttt cctctacctt taaattctat tatttctttg tctcttaata
    11521 tttgaagctg ttgcctaatc ttttctttga tatgattgtt cttaacaaag atatttttta
    11581 ggtcactttc aaaacgatac atatcttcaa gggtaaattc tgaaccctct atcttatcta
    11641 tacaatttag aatttctatt gtccaacctc ttgatgacag agagctcttc cttaaaaata
    11701 aaccttgctt aaattctttt gtaacttttt ctggatctct aacttgtcca tcttgcacaa
    11761 gaaatatcct tcctttagaa ggtacttgtg ataaatcaat gttacaacca atccaacctg
    11821 ctcgtctagc agttggtgca agtggttttc tttgaataat cgatttcggt gtaacaaatt
    11881 gcttcggaag gacaagaaag ttatttacct caaaattttt tgtgtaagtt aaaaaaaaga
    11941 aattaggatt attatctgcc tgcacacgct tcatcatcgt tgcataagca ccatcattga
    12001 ttgttgatga aaaatttcct tttttgctct ttagttcaaa ctcctcacta caatgattac
    12061 agtaaaaatc tgctacaggc cgattatttt caaaatgatt taagggattg ttcccacaat
    12121 tagggcaata agactgacga taaacccaat cctccgttaa gatacgtgcc ttttggctat
    12181 tacttttata ggtttctact aattctaaat taaagtgtaa ttccatttaa aaattcctca
    12241 ctaatatgag aactcactcg atataagcaa ttaaaatcta ctataactag tataccacat
    12301 atatgtacct attacatttg tatttcatca ctctctttta tatttccttc taacatatct
    12361 cataaattaa aaatgagtga gataaattta tcccactcac ctttctttat atacttaccc
    12421 gtctttcctc agacctttgg cctgtgacaa acatggtaaa ggttgcttta cagacatttc
    12481 tgccctcttg attggtgata tccacatcca tcacacaggt tgtacgacct tgatggacac
    12541 attctccttt aatggtcaat acatcgtcga gttttcctgc cttaaggtag ttgatagagg
    12601 attggagtgt caccccatca agtcccagcg agataaccac caaaccactg atttggtcac
    12661 atagtgtgaa tagatagcca ccatgggcat tgccatagta gttgagcgac gagttcacta
    12721 ctttggtcgt caccacaacg tgaccatctc tcattttttc aatttcgtaa ttttcaaagg
    12781 cagatatagc gtcaaaatga aagtctttca tcgtttcctc ctgatatttc aaacgacact
    12841 atgatactac tttttatagg actgtgcaag gagaaagctc ctagtctagt aaaattccga
    12901 cctgttccac aaagcgcata aaggctgtct gcccttgttc tgtctgcttg tagactcctg
    12961 catcctcaag tacacgcaca aagatagcac ccacagagtc cttgacgatt gcaagggctt
    13021 tttctttatc cgttaggtct ggatgttggg atttgagttg gtctgcccac tcctgatgat
    13081 aatcggcaac tgtaacagct tctcctacaa gatagctagc gacttgctcc acttcttctt
    13141 tcagacgtgg tggcaagatt gccaagccca tgacctcaat caagccgata ttttccttct
    13201 tgatatgttg gacatccttg tggggatgat agatgccatc aggatgctct gctgaagtct
    13261 gattgtctcg caagaccaag tccaactcaa actgtccatc acgcttacgc gctattggtg
    13321 tgatggtgtg atgcggtgtc ccgtctgtct ctgctaaaat ctgcacacta gaatctgaat
    13381 actgacgcca ttcctggaaa atcttatcag ctaagttaat caaatcctct ttggaatccg
    13441 aagtcaagcg taggacagac attggccact tgataattcc agccttgacc tgctcaaaac
    13501 cagcaaatcg gaaggtcttt tgcaagggag ccaattccat aggaaatacg tgacggcctc
    13561 cctgataatg atcatgagtt agaatagagc cccccacaat cggcaggtcg gcattagatc
    13621 cagcaaaata tcctggaaac tgctctacga tagccaacag acgttcaaaa ctctgacgac
    13681 taatggccat gggacgatgc tggccatcta aaaagataca atgctcatta aagtaagcat
    13741 agggcgaata ctggaacccc cattcctgac caaccatttc aaaacggata atccggtggt
    13801 tgctgcgagc tgggtggttg acccgaccat ggtaaccctc attctctaaa caaagttgac
    13861 actgaggata attactagct tgcaccaact tggctaccgc aatctctttc ggatcctttt
    13921 caggcttaga gagattgatg gtaatttcaa gttctccata atcagatgga acacgataag
    13981 cgatattttt agcaatggcc ttgagtttga tgtagtcatt tttctgactg agttgataaa
    14041 aatcctctat cgcttgctca ggagagtgga cataggcttc ccagaagtca cgattgacct
    14101 gactcggata aggagtcacc aagtccatca gttcagtacc aaggatttca cgcgcagtct
    14161 gactatcctc aatcatctct aatcgaacgg cttcctcaac tagctggtcc ttgaggtcaa
    14221 tcaatttatc cagattggtc tcaacttcca aaacaccttc tcccactcgt gccaaaacac
    14281 ggttggtcag gtagattcga tccatttcct caaatgaact ttcagaaatt acatgtgtta
    14341 caaatttatc tactaaggtc actatagagc ctccttttga ctagtcaagg acgcgagtgc
    14401 cacctgcaac ttcagcgata tagaagcttg gagcgtatcc aactacttcc tcgtagtgtt
    14461 tgcctacagc ttccttaaag gcctcaacag tatctttttg aaccaaggca atggcacagc
    14521 caccaaaacc agcccctgtc atacgagcac cgagaactcc ttcttgtgcc caagctgtgt
    14581 gaacaagagt atccaattcc aaaccagtta cttcataatc acgctccaga gaaacgtgtg
    14641 acgcattcat caaacgacca aatgtttcca aatcacctgc ttgaagggct gcttgagctt
    14701 taagggtacg ttggttttca agcacagcat ggcgagcacg tttcaaacga ttttcatctt
    14761 taatcagata gctatattgg tcaacggccc actcgtccaa ttcacccagg gtctgaatat
    14821 ccaaggcaac ttgcaattct tccactgctt tttcacactc agcacgacgt tcattgtatt
    14881 tagagtccgc caattcacgg cgtttgttgg tgttcatgat aacaacgaca ttgtccttca
    14941 aatcaagtgg caccaagtcg tattctaaag tattggtatc taagtaaata gcacgttggt
    15001 cagcccccat accaatagca aattggtcca taatgccaga atttactccg ataaagttat
    15061 tttctgtttg ttttccgatt ttaaccaaat cgagacgctc tagttttaaa tcaaagagat
    15121 gctctgccac gactcctgtc aagagctcca aggatgctga agaagacaaa ccagcaccat
    15181 ttgggatatt cccataaaca taaaaatcaa aacctttgtc aatcacgtgc ccagcttctt
    15241 gcaagaaatg aaggacacct tttggataat tggtccagtt gtgctctttt tcaaacttga
    15301 ggtcagcgag aggcacttcg ataatgccct tgtcctcaaa gttagctgag tagaaacgca
    15361 agacttggtc gtcacgctta cgagctgcac cgtaagttcc caaggaaata gcagcaggaa
    15421 aaacgtgccc accgttgtag tctgtgtgtt caccaatcaa attgatacga cctggtgaaa
    15481 agaaagtttg gtctgcttct tgaccaaaaa cagcaagaaa gtctttgcga agagtttcag
    15541 cagtaagatg ttgtgtcata tgatttctcc tttgactgtc cgttaagcca ccttaacgtg
    15601 taatcgtttt cttctattgt atccaaggga tttcccaagg tcaatccttt ttactaaaat
    15661 tttactaaac tatcagtaaa aagaagaaac cagacaccgt attttaaccg ttgctgaaga
    15721 gctgggctac accaagcacc tcaagacagg cgagtcccat aaacccaagc aaaagattgc
    15781 cattatccaa tgggtcagcg aacaagggga gctagacgac ctctactact accagattcg
    15841 cctaggaata gaaaaaagag cccaagagtt ggactacgat atcttgcgct attttaatga
    15901 ccaccctttt accctaagcg aggaagtgat tgggattctc tgcatcggaa agtttagtcg
    15961 agctcagatt tctgcctttg aagaatacca aaagcctctt gtatttctag acagcgatac
    16021 actttccctg ggacatacct gtattatcac ggatttttac actgctatga aacaggttgt
    16081 cgattatttc ctcagtcaag gaatggaccg tatcgggatt ctaacaggcc ttgaagaaac
    16141 aactgaccaa gaagaaatca ttgaggataa gcggctggaa aatttcagaa actacagtca
    16201 agcaaaagga atctatcatg atgaactgat ctttcaagga aactttactg cccagtctgg
    16261 ctatgacttg atgaaggaag ccattcagaa cttgggagac caactcccac cagcattttt
    16321 cgcagccagc gatagtttag ccatcggtgc ccttcgtgcg ctccaagaag ctggaatcag
    16381 cctaccagac cgtgtcagcc tcatttcctt taacgacacc agcctgacca agcaggttta
    16441 tcctcccctc tccagcatca cagtctatac tgaagaaatg gggcgagcag gtatggatat
    16501 tcttaacaag gaagtcctcc acggtcggaa aatccctagc ctgaccatgc tgggaaccag
    16561 actgacatta agagaaagta ccctaaatca agaataggat aacataaaaa acgaatagag
    16621 ttctaaaact cctattcgtt ttttattcga ttacaatcat agacttaatt gtcttacgtt
    16681 catccatatc tttataggct tggtcgatat cttccagttt ataacttgaa gtaaagacgc
    16741 gacctggatt gatatcacca tcaaggacgg cttttagtaa aaattgctta tcgtatgttg
    16801 tagcagaagc tgccccacct gctacagaga tattttgcat aaatgtcgaa ccaagagcac
    16861 gattattata gtgtgggact cctacaaagc ccatacgccc tccattatga agaacaccta
    16921 gcgcctgttc tatagcagcc tccgtaccaa cacattcaag tgctgcatct gctcctccac
    16981 cgaggatttc acgcaccttg gtaattcctt cttgaccacg ttctgcaaca acagctgtcg
    17041 cacctgactc catagccatc ttttgacggt cttcatgacg gctcataagg ataatttgtg
    17101 atgctccacg catcttagcc gcgatgacag cacattgacc aacagcccca tcaccgataa
    17161 caacaacctt gtcccctttt tgaacatttg caacacgcgc cgcatgatag cctgtcggca
    17221 tgacatctgc aagagtcaaa agggacttga gcatcccttc tgtatagtca gaaggttgac
    17281 cagggatttt aaccagcgcc cagtttgcat agtggaagcg aatatattct gcctgaaaat
    17341 caccccccaa attattgcca atatgattgt cgcaagaacc gtcaaatcca gcaagacagg
    17401 catcacactc accacatcca tgtgtaaaag ggacaatcac aaaatcacct ggtttcaccg
    17461 tcgtaatggc ttccccagct tcttcaacaa tcccaatcgc ttcgtgtcca ctatttttgt
    17521 gtccagcttt cgtttctgga ttacggtacc tccataaatc tgaaccacaa acgcacgcac
    17581 gaaccacacg aataatcaca tcatccgctt ctattatttg cggacgttca atgctagcaa
    17641 gtccaacctg acctgccttt gtatatactg ctgatttcat ttaaaatttt ccttccttat
    17701 aaagtttaat tttgagattt aaacgattta aagctgtctg tagctgagac aagcgctcct
    17761 ctaatttttg cttttcctct tctaaaatac caagcctctc ctctctcgtt tcatctccct
    17821 tttggtagag cgacatatag tcaactaaac tatctacaga gacacccgcc gaacgaaaac
    17881 acttaataaa ttccagcgct tcgatatcct gatcttgaaa atcacgaatc ccagtagcag
    17941 tacgagtaat cggtggcaca agaccaaccc gttcataata ccgaatcgta tccgctgaaa
    18001 ttcccaacaa atcactggca gatttaatat tcacacgcta acctcctctc atttcattca
    18061 ctgagttcac gctattctaa ctcacttatc ttattatata actttgagtt gactccaagt
    18121 caagcatttt gtatctaatc gaaaaatttt tatcattaac aatcatatat ctggagttta
    18181 tacaatgctc ttctcttacc aatttttgaa atatttaaat aataaagaaa ttactctatt
    18241 ccaaataaga tagtacccaa gtatttttca cttttttcta atgttgatgc tcataactcc
    18301 gttccaagtc acacaccttt cgcttatggg tttgatgagt ttctaggtca gcatcaattt
    18361 caatggtaat attttgaaaa ccacaatctt ttaggaaaat tcgaatagac tctttacaag
    18421 tttccatatg ttccatttct tttagacaaa catggacaat ggcatttttt tccaaagcat
    18481 ccatagtcca gagattaagc tgattaaggc tggccacatt gtccaatcgt tccaggccac
    18541 tctttacttg cttgatatca agaccttctg gcacagcatc caagaaaatc ttgagtgtag
    18601 accaaaaacg tgaaagggct tttgaaagaa taaagaaaga aatgacaagg gacaaaagag
    18661 gatctaggat ataccagtcc gtaaatcgaa gaacaatcgc catcaggata acagctaccc
    18721 accctagcgt atcttccaga aaatgcagac tcagaataga ctcattcttt gtctttccct
    18781 taccaaccac cagactcgct aacagattga tagtaatcgc aataattcct aaccagagaa
    18841 tcccctcatc attgactggt tgcggatgca aaatcttcgt gacattttcc aaaatgacta
    18901 gaacagagcc tgttacgaga atcacagctg ttaccaaggc tcctagtagg ctaaaccgct
    18961 tatagcccaa ggtgtactga ttgtcttctt cacgattgga gattgtttct agaaaagctg
    19021 atattccaat tgcaatcaca tctcccaagt catgcacaga gtcagcaaga acagcgctag
    19081 aaccaaatac tccacctgca ataaactcaa caatggcata agtcaaattt aagaaaaaag
    19141 ccacccaaac agcatatttt gccttcatat ttctcattcc tttgttataa taggtttatg
    19201 aacaccttgt tcattatcat tatccactaa aactcaaaga aaggatagaa gcaaaacgtc
    19261 agctttattc agttctgaac aatttgcctt aagtgtccat atgactaaca ttgaccgccg
    19321 tatcagcaaa accaaaaaag ccatctatca agcttttata caacttttga atgctaaggg
    19381 ctacgaggcc actactgttc aggatatcat tgatctcgca gatgtgggaa gatccacctt
    19441 ttactgtcac tatgaaagta aggagcttct tctggaccag ctctgccgct acctcttcca
    19501 tcatcttttt gaaagagagc aagccatttc aaccgaggac tacctcgccc acctctttct
    19561 ccattttcat aaaaaccaag accatatcac cagtctgcta ttttccaaaa atgactactt
    19621 cctccgtcaa ctccataaag agctagaaca ccatgtctat tccgtgctag ctgataattt
    19681 aaaagaagcc caccctaata tgcctacttc ttacctccaa cacttggtcg tgtccaactt
    19741 tatcgagaca ttgacctggt ggctcaaaaa aggtcaagat ttcacagacc aggaagttgt
    19801 ccaattttat ctagaccttc tcattcctaa aaattgaata tagagtaaag ctcagttgtc
    19861 ttatttctag gttactgagt tttttatctt ttcaacaaca aaagaggacc cgccgatcct
    19921 ctttttcata ctataaatcc ttgattatca actatatctg ttttaatcga aatctcaaaa
    19981 cagcactttc aaacatcttt tcctagttaa gtaaatcagt attctgctta gctgccttgc
    20041 tccattgata ccaaccaact agactgttaa tgagataaat tagatatttc ccttgaattt
    20101 gcaggctttc tccccaccag agatagattg aaaaaacatt ggtagccgcc cagaatatcc
    20161 actgttcacg gtaaacagct gtcatgagga tttgccctac cccattggtt gcatctgtga
    20221 ttgaatcacg atagggacga ttggcaccaa tagactgata aatgaagcca aaggccaacc
    20281 accaaagcac actaatggaa agatactttg tccagccctt gccgtccagt ttacgcgcga
    20341 caaactcctg cttttccttc ttaaactgtg cctgataaat ccaaactaga agtccaattg
    20401 gctgcatgac tgtgaagtaa agtgtcgtca gcacctcacc ataaaagcct ttctgtaggg
    20461 ccaaaataag gtaaataaca gagttaatca agccaaaaag ataattactt gctcgacctt
    20521 ccgatacaaa gattacacag ataatccctg tcaagctaca aatcatccca atccagtcaa
    20581 caatacgatg ttcgtaaacc aactccagcc agagaggaaa acttcctaaa accagcaaat
    20641 aaatccactg ggcaaaacta cgatgggcaa agaggtcatc ccagatagcc ttcatagttc
    20701 ctgaaaatcc taaatcagcc atagccgcaa ccatacgacg gtaaccacct gacatttcac
    20761 ctagggttgt tttgatattt tcaattttct tttgcaaata agtatgcatc atttctcctt
    20821 ttgtttttaa agagccgtgt ctggatagac tttcggacgc aacgctctat tagataatga
    20881 actgcctata cacaagattt ctaaccttag tcgacatgag ctgaaacctc ttatttgtta
    20941 agtagttcac aaaatattat acacctattt tatgaatagt caactgtctt tacagtaaaa
    21001 ttttagaaaa tcatgaaaat tttctctttc tttccatttt aagtgacatt cagtcattct
    21061 cacatcaaaa aagcccagac gaaattgtct gagcattctt ttatctagtc gtttaaggaa
    21121 gttgagttca gtatgtttaa agtctctgtc ccatcatttc ttcaacaaac cttgttcttg
    21181 gagaaactcc ttggctactt gctttgctga cttgccttca acaccgactt ggtagttgag
    21241 ctggctcatc tggctttctg taatcttacc agccaatgta ttaagaactc tttccaactc
    21301 tgggtgtttc ttgagaagag cttctttcat gagtggagcc ccttgataag gtgggaagag
    21361 ttgcttgtca tcttccaaga cctgtaaatc ataacgctcc aattccgcat cagtcgaata
    21421 ggcatccgtg atttgaatat cccctgactg aattgcctga taacgaagag ctggctgcat
    21481 agtcgccaca ttgagattga gaccatacat tgattgcaag cccttatttc catcttcacg
    21541 gtcgttaaac tcaagcgtaa agcctgcctt cagctgccct tccacttttt tcaaatccga
    21601 aatggtcttc aagccatatt cttgagcaat ctttttcgga acagctacag cataggtatt
    21661 ttgataagac ataggtttga gataggctag atgatcctgc ttggcaatgc catcacgcgc
    21721 cacttgataa acctgctctg gctcatgact caccttgggt gatggttgaa gcaaactttc
    21781 agtcaccgta ccggtaaatt caggataaat gtcaatatca ccttttttca gagcttcata
    21841 aaggaaactt gtcgtcccaa aattcggttt aacagtcgca gtcatgctgg tattttcttc
    21901 aatcagcaat ttatacatat tagccaaaat ttctggttct gggcctattt tcccagcaat
    21961 aatcaagttt tccttctctt tttgagccaa aagggctgga ctataagaca gacccagtaa
    22021 taaagccacc aaggcaaaac cagagaaaat cgtccgcaat ttcgcttttt ccattacttt
    22081 tagtaggaag ttaaaggcaa tagctagcac tgcagaagaa agggccccaa tcaaaatcaa
    22141 actggcatta ttacggtcaa ttcccaacag gataaaggaa cccagtcccc ctgccccaat
    22201 caaggtcgcc aaggtagccg taccgataat caagaccgct gccgtccgaa ttccagacat
    22261 gataacaggc atggcaagtg gaatttcaaa cttcttgaga cgctcccatc tggtcatccc
    22321 aaaggcaatc ccagcctctt gaagactcgg atcaattccc ttcagcccag taatagtatt
    22381 ttgtaaaatc ggaaaaatcg cataaatcac tagagctgtc aatgccggta aagtcccaat
    22441 tcccatcaag ggaataaaga gtcccaacaa ggccagagac gggatggtct ggaaaatccc
    22501 tgcaatctgt aagacccaat ccgccaactt ctcatgatag cgaagataaa cagccaaggg
    22561 aatcgcaagc aaaatagcta gtaacaaggt caaaagtgac aactgcaaat gttgagatag
    22621 ggctgtcaac caatcaccaa aacgatcctg aaaagttgca attaaattag tcatgaacac
    22681 tacctccaaa caagtctgca acaaagtctg ttgcaggagc ttttaaaata gtctcaggat
    22741 tcgacacctg acgaatctct ccatcctgca aaacagcaat acgatctgcc aactttaagg
    22801 cttcatccgt atcatgagtc acaaaaatcg ttgtcatccc aaactcttta tgtaattctt
    22861 ttgtcagaac ctgcaactgc ttgcgagaaa tagcatccaa ggctgaaaag ggttcatcca
    22921 tgaggagaat cttgggctga ccaatcatag ctcggacaat accgacccgt tgctgttctc
    22981 caccagataa ttcactaggt aagcgatgcc catactcggc tactggtaaa ccaaccttag
    23041 ccaaaagctc ttctgttttc ttcgtaattt cttccttgct ccaccccttc atttcaggaa
    23101 tgagagcaat attttccgca actgttagat ttggaaaaag agcaatagcc tgtaaaacat
    23161 atccagtagt aagacgaagt tcacgctcat catagtcttt gatgcgcttg ccatccatat
    23221 aaatatttcc atcagttggt tccaagagac ggttaatcat cttaatcatg gtcgtcttac
    23281 ctgacccaga aggcccaact aaaaccatga actccccatt ctcaatctgt aaattgacat
    23341 ctctcaagac atctttttct gtgtagcgca gtgctacatt tttgtattca atcattcttt
    23401 gtcctcaatt taaaacttcc ctcgattagt caagtcttct accttaggca tgacttcctt
    23461 attatcccaa tgctccacaa ttttcccgtt ctctaaacgg aagatatcgt actgggcata
    23521 agcaacgcca tcaatctgag tctgaccata gctaaccaca tagtttcctt gtcctaagag
    23581 ttggaaaaca aagtcaaaag tgacactata ttcagccaca tagtttttat aagcagcact
    23641 tccttgtcca atctcatgat tatgctgaat caaatcgtct gccacataat cattccactg
    23701 ctctagctcc ccattttgga aaatttctgt caagaaacgg cgaaccagct ttttattttc
    23761 tgctttcttg tccaaatcct tgatttcaaa atctccaaaa atttgatcta gttggtcatt
    23821 ttcaggtgtt cgatagtagt caatgacatc ccaatgctca acaatacgac cattctcatc
    23881 cgcacggaaa gtatccgtcg tcacccattg agcttctcca ccattcagat attgatgaac
    23941 atgaacaaag accagattgc catcctcaat ggtgcggaca atcttaatct gacgctctgg
    24001 atgacgctca aagaaatctg caaagaaggc tgcaaatcct tctttcccgt caggaacacc
    24061 tgtcgaatgt tggatatagg tatcccctac agactgggct tgagcctcag aaactcgtcc
    24121 gtcttgaatg gcatggatgt ataggttgtg agcatttttc acttgttgtg acatattcta
    24181 aacctcattt tccttctctt tcagatttgc caaaattctt tcttgaaaac cttcaaactg
    24241 acgaatttct tcctctgaaa atcctttgta acagatagta tccaatctct gactgacacg
    24301 ttgcccaact tctttctggg acttgcccaa ctctgttaaa actaaatact tcttacgctt
    24361 atcttctcca cacggactga cagttacaag attttgttcc tctagatttt ttatcatagt
    24421 cgtcagcgta ttattagcaa gcccagtcgc aagcgcaatg tctgtcgccg tagcacagcc
    24481 tgtctcacta ttccataaaa ccgctaaaat ctttccctgc tcactccgat aaagagagtc
    24541 agggtcttgt cttagtaact tttgaaaaat ccgcccattc aacaaacgaa tatgatgggc
    24601 taccaaatga caatatttca tgaaacctcc aatttatttc tatatcgaaa tagataaagt
    24661 gattataaca ctcatcattc catatgtcaa ctatttcgat ttagaaataa tttttgataa
    24721 ttatttacat caccatactc cggatcaact aacttttaag gagagtttct aaactccttc
    24781 gtcctccagt ctacaaaagc ctttcatccg tactatccta tattttatga ggggacacat
    24841 ttttcctatc agaccattta ttttaaagat agaagtaaat cataattgct tccatctgtt
    24901 cttttatagt atattgaagt tgaactagga cactgtatct tctaaaacat tgataaaaag
    24961 cgacttgaat ttcccaatca atttgttcgt atttatagca tttcgaaact ggaataggac
    25021 accatgactg ctaaaagatt tctataaatt catttgattt ccctaatcaa tttgttcata
    25081 tcttatttca ttccgctata atttcacctt gccctatctt tttcgtagca cccttcaaac
    25141 agcctatccc ctaccgtttg acgattcctc acttcactcc acttccatta cagaagtttc
    25201 ttcactacta tggtctcggc tgacttctca tgattccttg ttactactat ttgaacgctc
    25261 acgagatagg tcttataaaa aatgctttga tccacaatgg aatcaaagca ttttaaaaag
    25321 ttcctcatac ataagcgcag aagtcgcagt tcctctgtac ttggcttctt ctcttttgat
    25381 aaagcgagcc aagttgagca actcaggtgc tggatgtttg ggatttagga gcaattcacg
    25441 attgaccagg cctgagagac gaactgcctg caattgctca tttgtagtag gcagtttttt
    25501 agtagtctct aggagagcag caactaaatc ttcactcaaa tcatgtcgag catgattgta
    25561 aagatctttt ataaggcttt ctaggtttgg ttctaccatc cctaccacct cccttatggt
    25621 ttaataatgt ttaatcaaat caaccgttga acgatccaat ttcttcacca aggcttgtaa
    25681 gaaagcttgc gcttctagga agtcatccat tgcatagagg gtttggtgag aatggatata
    25741 acgagcgcag acaccgatag ttgttgatgg gacaccacca tttttcagat gagctgcacc
    25801 tgcatctgtt ccgcctttac cacagtagta ttggtacttg ataccagctt cttcagccgt
    25861 tgtcaaaagg aaatccttca tccctggaag aagcaagtga cctggatcat agaaacgaat
    25921 caaggttcca tctccaatct tgccttgacc accgtagaca tcacctgctg gtgagcaatc
    25981 aactgcgagg aagacttctg ggtcaaactt ggttgtagag gtatgagcgc cacgcagacc
    26041 aacttcttct tggacgttag aacccagata gagttcattg ccgagttttt gacctgataa
    26101 agcttcagct agctcgctta ccatgaggac accgtagcgg ttatcccaag cttttgagat
    26161 gatatttttt tcattggctg tcaaaattgc agaactatct ggtacgatgg tatcaccagg
    26221 acggatgcca aaactttctg cctcagcctt gtccgcaaaa ccaccatcaa aaacgatatc
    26281 ggcaatggct ggcatggttg gtcccccctt tccacgagtc aaatgcggag gaacagaacc
    26341 tgaaatcaca ggaatttcat gaccatcacg agtcaagagt ttgaaacgtt ggctgctaac
    26401 caccatgggg ttccagccac cgatttctac gacacggaag gtaccatctg gcttgatttc
    26461 gctgaccata aaaccaactt cgtccatatg agaagcgacc aagacgcgcg gtgcatccac
    26521 agcttctgaa tgtttgatac caaaaatacc acccaagcca tctgtcacca cttcatccac
    26581 atgcggtgtc aacttttcac gaagataagc acggacaggc gcttcatgac ctgagactgc
    26641 agcaagttct gttacttctt taatttttga aaataatgtt gtcatttcag ttccttcttt
    26701 ctttcatcca ttttaccact ttttatagga gaaggatagt gggaaggtgg atttctaagt
    26761 tagtatctta gtcctgctct atcttagaaa aggatagtat tctcttgcat gtagtgcaaa
    26821 atctagtaaa cattccaaaa ttaactcgaa tatttatttc caaacaaaaa aacaatacac
    26881 catcaaagtt gtttagattt tttatgaaat ttacagaaaa tagttgactt ccctttcttc
    26941 tttctttaaa tatatagttg gttgagtttg gaatagtacg ctgtagctgc taaaacattt
    27001 ctagaaatta atttgacttt cctaatagag ttgttcatat cttatttcaa tttactatag
    27061 tacaaaacta gaaaaggaaa aaatcatgac caaaacaatt cttgttacag gtgggactag
    27121 ctacattggc tcccataccg ttaaagctct tttaaatgct ggctataagg tgcatgtcct
    27181 cgataatctc tccacaggaa atcgagcggc tgtggatagt cgtgctagct ttaaagaact
    27241 ggatgtttat gatgctagcg ccttaaaggc ttacttagaa gaaaatcaga ttgatgctgt
    27301 cctccattgt gcaggtgaaa ttgttgtgag cgaaagtatt gaaaatccaa gtaaatactt
    27361 cactgccaac gttgctggta ggaaccaagt tctcaaagtc ttatctgaag ttggcattca
    27421 aaaaatcatg ttctcttcga ctgcttctct ctatggaaat aactgtattg acaagccggt
    27481 gactgaagat accctgctcg accctgtcaa cccttatgca gagacaaaac tgatgggcga
    27541 acgaatgatt tactggatgg ccaatcgcta cgactggaaa tatgttattt tccgttactt
    27601 taatgttgct ggggctgaaa tggatgcttc aaacggtctg cgtgtgaaaa atccaactca
    27661 catcattcca aatatcaaca agaccgcatt gggacaaaat gatagcttaa aaatatttgg
    27721 agatgactac gatacacatg acggttcatg tattcgagat tacatttatg tcttggacct
    27781 tcataggctc atgttaaagg aatgaactac ctatttcaag aagacagttc ttctcaaatc
    27841 tttaacttag gaactaaaaa aggctatact atcaaagaaa tctttaaaac tgctgaagaa
    27901 ttactaaatt aaaaaatccc acacgagatt gttgctcgac gtgctagtga cccagccagt
    27961 gtcctagcag atgcttcaaa agctaaacaa tatcttgatt ggacggctag ctactccctc
    28021 gaagatatta ttttatcaga ttaaggtaaa aacattttag aataggataa caaaggagaa
    28081 agtcttgttg ctctctcctt gttgtattta ttaaattgtc agaaatttta ttgacagatt
    28141 agaaaaataa tgttacattt atatccgcag atatctttcg ataccaaatc tacatgaaag
    28201 gacggggtat gaaactttct tattatttaa ttggcttact tctactccta gtctttctct
    28261 ctattagcat tgggaccagt gatttttcat ggggaaagct atttgatttc gaccagcaga
    28321 cctggctcct ctttcaagag tcccgtctcc caagaactat cagtattctc ctgactgcct
    28381 ctagtatgag tatggcaggc cttctcatgc agactattac ccaaaatcag tttgctgcac
    28441 cgagtacagt tggaacgact gaagccgcca aactgggaat ggtgctgagc ctttttgtct
    28501 ttccatcggc tagtctgacc caaaagatgc tcttcgcttt tgtttcatcc atcgtattca
    28561 ccctcttctt cctagccttt atgaccattt ttactgtaaa ggaaaggtgg atgttgcctc
    28621 tgattgggat catctatagc gggattatcg gctcagtcac agaagttatc gcctatcgtt
    28681 tcaatctggt tcagagtatg actgcctgga cccagggctc cttctccatg attcagaccc
    28741 atcagtatga gtggctcttc ttaggcctca tcatcctgat aaccgtttgg aaattatccc
    28801 aaaccttcac catcatgaat ctagggaaag aaaccagcga gagtttgggg atttcctact
    28861 ccctacttga aaaactggcc ctctttctgg tggcgctaac gacaagcgtc accatgatta
    28921 ccgtgggtgg cctaccattt ctcggagtta tcgttcccaa tcttgttcgc aagtgctatg
    28981 gagataatct aagtcaaacc aaactcatgg tcgcactggt tggtgccaat ctagttctgg
    29041 cttgcgatat cctatcccga gttctgatta ggccctatga gttgtctgtc agtctcttgc
    29101 taggaatcat cggtagtctc gtctttatcc tacttctctg gagaggggga cgaaaagatg
    29161 cagactaaaa gcaaacatac caagctcttc tggattctca ttattcttgc catcggagct
    29221 tgtcttctct acttttggcc catcactcac ttgtcagcct ttgcttggaa gttgcgttcc
    29281 caaaagatca tcgtttatct cttggtagcc atcgcgactg ggatttcgac cattagtttt
    29341 caaaccctga cggaaaatcg cttcctgacg cctagtattt tgggaattga atccttctac
    29401 gtcctactac aaaccctact actggttttt gaaagcaagt ttcttcaact tggcaaatcc
    29461 cctatcttag aattcctagt cttacttctt gtccagtccc tcttctttct cgccttacaa
    29521 ggttacttga agacactgat gaagcaagac ctggtcttca tcctgctgat ctgtctagcg
    29581 ctcagaagtc tctttcgaaa tatcagcacc ttccttcaag tcctaatgga tccaaacgaa
    29641 tacgataaac tgcaaaatag tctttttgcc tcctttcaac atctcaacac ttccatccta
    29701 gccatcggtt ctctgatcat cctcgctttg acaatctttt tctttcgaaa agcagtcgtt
    29761 ctagatgtct tgcacctgca aagagaaacg gctcagatat tgggactcga tgttgaaaaa
    29821 gaacagaaag agctcctctg gggaatcgtg cttttgacct caacggccac tgccttggta
    29881 ggacctatgg ccttcttcgg ctttatactg gccaacctca cctacctgat tgtcaaagac
    29941 tatcagcaca agttactctt tatagtggcc attctggttg gatttattag cttaaccttg
    30001 gggcaagcct tgattgaacg agtctttgca ctggaaattc gtatcagtat gatcattgag
    30061 agtgtgggtg gcttcttatt ctttatctta ctatatagga ggtctcgtca gtgaaactgg
    30121 aaaacattga caaatccatt caaaaacagg atattttgca aggcatttcg cttgaagtca
    30181 gtcctcaaaa actgacagcc tttattggtc caaatggtgc tggaaaatcg actctcctct
    30241 ccatcatgag caggctaacc aagaaagatc agggagttct cagtatcaaa ggacgtgaaa
    30301 tcgagagctg gaattcgcaa gaactggccc aagaactaac catcctaaaa cagaaaatca
    30361 attaccaagc caaattgact gttgaagaac tggtcagttt tggacgtttt ccctacagcc
    30421 gaggtcgact tagatcagaa gactgggaaa aaatccgaga aactctgaac tatttagaac
    30481 tgaccaactt aaaagaccgc tacatcaata gcctgtcagg ggggcaactc cagcgcgtct
    30541 ttatcgctat ggtactggcc caggatacgg actttatctt gctggacgaa ccactcaaca
    30601 atctcgatat caagcaaagc gtcagcatga tgcagattct tcgacgactg gtggaggaac
    30661 tcggcaagac cattatcatc gtcctccacg atatcaacat ggccagtcag tatgcagatg
    30721 aaattgtcgc cttcaaggac ggccaggtct ttagcaaggg aagaaccgat caaatcatgc
    30781 aggctgacct gctcagtcaa ctttatgaga ttcccatcac gctagctgat atcaatgaca
    30841 aaaagatctg tatctatagc tagtaacata aaagctcaag ttagagaacc ttcagtctct
    30901 tagtcaataa gattaagaga ctccctaaat cgttatcaca ttttaaaaag gagaaattat
    30961 gaaaacatcc cttaaacttt atttcactgc cctagtggcc agcttcttgc tcctacttgg
    31021 tgcatgtagt acaaactcaa gcactagtca gacagagacc agtagctctg ctccaacaga
    31081 ggtaaccatt aaaagttcac tggacgaggt caaactttcc aaagttcctg aaaagattgt
    31141 gacctttgac ctcggcgctg cggatactat tcgcgcttta ggatttgcaa aaaatatcgt
    31201 cggaatgcct acaaaaactg ttccgactta tctaaaagac ctagtgggaa ctgtcaaaaa
    31261 tgttggttct atgaaagaac ctgatttaga agctatcgcc gcccttgagc ctgatttgat
    31321 tatcgcttca ccacgtacac aaaaattcgt agacaaattc aaagaaatcg ccccaaccgt
    31381 tctcttccaa gcaagcaagg acgactactg gacttctacc aaggctaata tcgaatcctt
    31441 agcaagtgcc ttcggcgaaa ctggtacaca gaaagccaag gaagaattgg ccaagctaga
    31501 caagagcatc caagaagtcg ctactaaaaa tgaaagctct gacaaaaaag cccttgcgat
    31561 cctccttaat gaaggaaaaa tggcagcctt tggtgccaaa tctcgtttct ctttcttgta
    31621 ccaaaccttg aaattcaaac caactgatac aaaatttgaa gactcacgcc acggacaaga
    31681 agtcagcttt gaaagtgtca aagaaatcaa ccctgacatc ctctttgtca tcaaccgtac
    31741 ccttgccatc ggtggggaca actctagcaa cgacggtgtc ctagaaaatg cccttatcgc
    31801 tgaaacacct gctgctaaaa atggtaagat tatccaacta acaccagacc tctggtatct
    31861 aagcggaggc ggacttgaat caacaaaact catgattgaa gacatacaaa aagctttgaa
    31921 ataagccact tcaaactcaa tttaatactc aatgaaaatc aaagagcaaa ctaggaaact
    31981 agccgcaggt tgctcaaaac actgttttga ggttgcagat gaaagctgac gcggtttgaa
    32041 gagattttcg aagagtataa aattttgaca ttctaaaacg catcctatca agttcactca
    32101 aacctgatag gatgcgtttt tatcattttg aaatctattt accccacctc attccccttc
    32161 ttgatttcgt ttaagggaaa agtggtctgg aacggggtcc ttacctgttt tcgaccaggg
    32221 atgacaacgt aaaatccgag ccaagcccat caataccccc ttaaaaccat gtttttcaat
    32281 agcctgaatc atgtagttgg aacaagtcag ctcaaagcga caagagggtg gaaagactgg
    32341 tgagataaaa cgttggtaaa agcgcacaag cgctattaaa attcgtttca ttatttctta
    32401 gttacagcca tggtgtgtag ttggctgatt tcttttttat taagacgacg ggattctcct
    32461 ggacggagtc ctgtcaagtc taggtgtccg aaacgagtcc gagacaactt atctacttgg
    32521 agaccaacag cttcaaacat ctttttaacc tgatggttac gcccttcatg gatggtcaac
    32581 tgcaccacag agcgattttt gactgggtcc actttgagaa tttcataaac agctggcttg
    32641 gttttcttac catcaatctc aagaccacgg gtcaaggggc gaagattgtc cttattggcc
    32701 acacctttaa cacgcgcgac ataaaccttg tcaatctcat tacgagggtg aatcatctcg
    32761 tctgtaaagt ccccatcatt ggtcaaaatc aagactcctg atgtatccca gtctaaacga
    32821 cccacagggt aaatacgctc tttgacattg ggcaagaggt cgacaaccgt cttgcgaccc
    32881 ttatcatctg tcacactgga aatgacaccg cgtggtttgt taagcagata gtagaccttt
    32941 tcttcgttgt agataggttg accttcaact tcgaccttgt cgcctgactt gatagtggtt
    33001 gctagttcac gcaccacttg gccgttaacc gtcaccaagc cttgcttaat cagctcttct
    33061 gcttttctcc tactggccac acctgcgtgg gcaatatact tattgattct catcttcttc
    33121 tatcctttca ccaaataatt ggctttcttg ggcttgaatc tcaagctcat caatcactgg
    33181 taattcttct aaatggttta tccccatgta atctaggaaa taatccgtag tcacatagag
    33241 gttggggcgc cccaatactt cctttttccc gtcttccttt atcaggtcaa aagcctgcaa
    33301 ctttgccaag gctccactcg agttaactcc acggatggca tcaatttcta tccgcgtaat
    33361 cggctgtttg taggcaataa tggacaaggt ctcaagggca gcccgagaca agctctggtt
    33421 gataggcgcc ttagagtatt ccttcaaaat ctctgcaaat tgaggcttgg tcaccaatct
    33481 ataagcacca cttgtctcaa tcaaagccaa actggaatct gggtcctttt catacttctg
    33541 ggctaatttt cctaaacttt gctggatgcc tgtcggtggc agagagagga gttcagctaa
    33601 ctggcggacc cgaatcccat cttcacccgc tacaaacaag agcgcttcta tttttgctaa
    33661 agtactcatc tttcctctct atcaagtcta gctttgaggc acttgacttt cttccttctt
    33721 ttccatgaga tagatatctc cgaaactctc ctcttgcacg aggatcagct cctgggtttt
    33781 gattaactct agggttgcca aaaagagggt gatgacctct tggacattct gggcttcctt
    33841 gaacaaatcc tgcaagcgca attgatctcg tccaatcaag gactctttca cgataatcat
    33901 catgtcctca atcttatact catcccgcaa gatagtcgtg tgattttgtg caaactcctc
    33961 ttttttcttg gctaggatat ttgaaaaagc caaaaagagg tcaatggtcg tcttgtcatg
    34021 cacaagctcc gcatcttcgt aaatcaactc tgtcggcgct ttggaataat actgggcccg
    34081 ttcttggtgc ttggattcca agtgctcacc caagagcttg aacttgcgat attcttcgat
    34141 ttgagagagg aggtcctgct ccaggtcatc ccccaagtct gtcacttctg ctaccttcgg
    34201 aaggagttta cgactcttaa tcagcatgag ctgactagcc atgaccatgt actcacccgt
    34261 cacttccaga cgcatggcct gcagggttga gacataggct agatactgtt cgatgacttc
    34321 cgtaatgggc acatcgtaga tatccatctg gtacttagaa accagatgca agagcaagtc
    34381 caagggtcct tcaaaatctt ttaatttaat atccattatc tatatttttc taaggtcagg
    34441 actgttttta atcctaattt ttttgcaatt tcgtacaaat cgaccttgtt ttctatttgt
    34501 cttagaataa actgttcacg taagacttga gctgataagg atggaaaacc tttctccttg
    34561 acaaaagatt ctaactgacg aaaggcccac tgacgagaat agggtttctc tcctctttca
    34621 aaaagatagg tctgccccat caagggttcc aattctgaaa gcaaggccgt gggaatggtg
    34681 acaatcctct gttgggaagc cttgctgatt cgcaacacct gaaaatccag attgatgtcc
    34741 gcaaccttga tggctaaaat ctcactgggc aagagcccca tttctaggat taagagcgct
    34801 agcaagcggc cctctggatg gtcgctttcc tgccaaaaag agtctaggta tagaatctct
    34861 ggcttttccg tcttcttttc agcttgtttg gctaattcca agcggtaaaa gctgtccacc
    34921 tctccttttt gatagagaaa gtatagaaat tggttacagg acgaaatctt tcgcttctgg
    34981 gcgctgattt ttagattggc tagctgggct tggtaaatct tgagactggt ctcagaaatc
    35041 cgctcaccta ccatgtctaa aaattgctcc aaatcatact tataggactg cttggaattg
    35101 acagacaagc cctgcttttc ctctaaaaag gctgaaatcc tgtctctcat tggcatcgaa
    35161 tctcatattc cttactaaag tcatgcaaga gggcattaac ggccttgagg atggacttgc
    35221 gcgtaataat cccttggaaa ataccctctg aatccacaac cggtaagaag gactcatcta
    35281 ctagcttgtg caagacctcc gtaatggtga aatcaggcga aacaaccgct acgtccgttt
    35341 ttgtcatatg aacgatatcc gtatccgcca tgatttcttg gctcaagtca tgctccatct
    35401 gataagccat aatatctctg agtccaatcg tcccaacaaa ctgtttttca tctgtcacaa
    35461 cgggaacacg ggtataggtc atctgactga gcaagagggt cgcatgatcc gcattgtggg
    35521 tatcaatcaa cacagctaga tttttagcag gggtcaaaaa agtttcctcc tgccccaaca
    35581 agaaagtctc aaactccttg gcaatcatcg gctaaactcc ttggacaaac ctggatacac
    35641 ctcgtgatct cgtgtcaaaa agtccacttt gaagtaacta tcatcaatct ccacacgagc
    35701 atagagacat tctctgatgg tacctcgtgg ttgactgata gaacctggat ttagaaagag
    35761 gatcttgcct tccatccaag cacttggcac atgcaagtga ccatagaggc agatagcggc
    35821 ctcttcctcc tgagcccagt agtccaactt ttgaaagttg aaattgatgt caaacaagtg
    35881 accatgagtt tggataatct tggtcgaacc aagctcagtc accagacgtt ctgggtagcc
    35941 ggcgtagaag tccatgttcc ctttaacaac gcggatgccc tcccaaagtg gagaatccgg
    36001 acgtagttca gaatcgccgt tatgaaaaac ggcatcgact ttgcccacat agcgatcacg
    36061 gacttcttcc acaatcaagc tatcgccatg ggaatcgctc attacaatga tggtttgctt
    36121 tgccatgatg gaaatacctc caaaagtttc ttaacggcta aggcacggtg agattgacta
    36181 tttttttctt ccagggttaa ttcagctgat gactcacctg tctctcctac aaggaagagg
    36241 ggatcatagc caaagccatt ttcaccctta ggttcaaagt taatataacc tgaccagtct
    36301 gcttcaacaa ctaaactttc cttatttggg ctggctacga ctagggttgt gtggaactga
    36361 gccgagcggt ccttgagttc aaagaccatg gccaattcgt gcaagagttt ggcattattt
    36421 tcacggtcag ttgctcccac acctgcgaaa cgagctgacc agacgcctgg taagccacca
    36481 aggacatcga ctttgagacc agaatcatct gccaaaacca tcttgcccgt taattgagaa
    36541 atggtttctg ccttaaggcg ggcattttct tcaaaggtca tacctgtttc tgctacttca
    36601 ggcaggtcag ggtagtcatt aagattttcc acatcgtagc ctaacttatc aaagatagct
    36661 cggaattcct tggttttacc ttcgttacga gtcgcaatca acaaggtttc tctgaccttg
    36721 cttgtctcaa agaaatcatg aacattgacc ccttctttag gcaattctac atacaagagt
    36781 tgcccatttt caaccaagag cagggcccca tgacgttgaa taacttccaa gtttcgtccc
    36841 atttcttgat taagcatgtc taccacaaag gagaacaaac ggtaggtaga accatagcgt
    36901 aaaacagtaa ctgaaagcgg gaaaccatac tcttcatctc caaatatttt ggagaattca
    36961 aacagaggaa aatctgtctt atagtcgctc aaactgttaa cgccaccaaa aatactataa
    37021 gacccaacat accagtcctg gtcatcctta tattcataaa ttttatttgt cataattcta
    37081 catgctccac atgaatctct ttttccagcc attcttcacc aatttgtgca aaactttggc
    37141 tactggctgt tgtgtaaaaa cggtgatgga gtggtccagc atcgcgacca cgattgattt
    37201 caaaataatt gagtaagact gagatatccc gtacgcactc tgccccacta tcgatgagct
    37261 gaacctttgg ccccatcaca ttttggataa tagggcgaag gagtggataa tgagtacagc
    37321 ccaaaatcag gctatccacc tttccaacca agggacgcag ggtttcatag accaccttct
    37381 tggtaacact ggttgacagg gcacctgact caaccaaggg agcaaacttg ggacaggcca
    37441 agctctccac ctgtaagtcg ggatccagat catggatttt ctgacggtat atgtctgatt
    37501 gtaccgtcat gggcgttcca atcactccga ttttcccacc ttgactggac ttgatggctg
    37561 ccgaagctcc tggcaaaatt acacccaaga caggaatatc tagttgagcc ttgatttctt
    37621 cccagacgac cgcagtcgca gtgttacaag caatgacaat cattttgaca tccttggtca
    37681 agagaaagtt gaccagctgc caagtatatt cacgaatttg ctcagcagga cgggggccat
    37741 agggcgcccg cgccgaatct ccaatataga cgatttcttc atggggaagc tggcgcatga
    37801 gctcgcgcac aacggtcaag cccccgacac ccgaatccaa aaaaccaatt ggtcgattat
    37861 ccatacagtc ttctttctag tcttttttct gattgatcgt tcattatgat tccttgtact
    37921 gaacgaactg accgacagct tgatagaatg tcaactacct ctctcttaat cataatcaaa
    37981 tatcaataga atgcaaggaa aaagtctcat ccctaaacca taaccaacat agtgagaagt
    38041 ctggaacttt catcccagac ttttccttat ttattttttc tttttattgt tagcaagggc
    38101 tgccttttgt tggcggatga tttggtggta aacttgttgt accttagctt cgcttggttt
    38161 ttgaccattt gcactcaaaa gagtacgaac tgcttcagca ttcaaacgtg ggttgtcagc
    38221 aaattctttt tcgatttgct tacgaaccaa gtacattcct ccaagagctc ctcctagaaa
    38281 agctagcaca atcaatacaa ttgctaaaag taaatccatc atttttctcc tgtttctttt
    38341 tgaatccctt tcattatacc acaaactagc caccctgacc agtttgttct acactttcaa
    38401 ggatggaata gacagcaaaa agaaccctgc ttttctgaaa aagaggtctc cttgctaagt
    38461 ttatactcaa tgaaaatcaa agagcaaact aggaagctag ccacaggttg ctcaaagcac
    38521 cgctttgagg ttgcagataa aactgacacg gtttgaagag atttgcgaag agtattaatt
    38581 tacataaata gccagtgttt gatagggttt gagtagaatt ttctcagaca cttctgcatc
    38641 ttcatagttt gatatcaaaa tctgtccatt ttggtagact gctggcaagt cgatttccac
    38701 ttctttagca taaaagttat tgagcactag taacttttga tcctcaaact ggcgttcaaa
    38761 agcgtagact tgtttgctat cttcaaaggc tggtttgtaa cttccttctg aaatgattgg
    38821 catttcctta cgcagtcgaa tcaagtcttg atagaaggta aaaatcggac cctggatttc
    38881 attttctaca ttgatgtctt tataggattt accagctttc aaccaaggag tgcctgttga
    38941 aaatcctgca ttttccgaag catcccactg catgggaatg cgtgaattat cacgcgactt
    39001 agcttgaata atctggaagg cttcttgctg actctttcct tcttctaaga gcatctgata
    39061 ggcattaagc gattcgacat ccacataatc agccatagaa tcatagtctg ggtcaatcat
    39121 cccgatttcc tcacccatgt agatataagg tgtcccacgt gacaggtgaa tgctggccgc
    39181 tagcatggtg gctccttcct tgcggaagtt ttgaatatcg acaaaacggt tcaaggcacg
    39241 tggttgatcg tgattgttcc aaaagagggc actccaaccg tctttatcac tcatttcctt
    39301 accccaacta tggtaaagac tcttcaactc ttcaaaatca aagggagcca aggtccactt
    39361 ttgtccatcc ttatagtcca ccttgaggtg atgaaaatta aaggtcatgg ataattcctg
    39421 acgatcaggc gacgaataaa ggacacagtt ttccatggtg gtagaagaca tttccccaac
    39481 tgtcataaag ctatcgtcag atccaaaagt ggcttggttc atcatacgca aatagttatg
    39541 aacgatgggt ttgtctgtat aagctggctt cccttcattt tcaggacagt ccactgaaac
    39601 ctcgtcctta ccgatcaaat tgatcacatc aaatcggaaa cctttgatac ccttgtcgcg
    39661 ccagaaatta acaaccttga aaagctcctt acggacattg gaattgcgcc agttaaggtc
    39721 agcctgggtc tcatcaaata ggtgaagata gtatttccca gtatccccga aaggcgtcca
    39781 tgcagaacca ccaaacttag actgccaatc tgttggttgg tcttggatga agaaaaagtc
    39841 ttgataatac ttatcaccag ctagggcttt ctgaaaccat tcatgctctg tcgaacaatg
    39901 attaagtacc atgtccagca taaagtcaat cttgtgctct ttaccgacac acaccatttc
    39961 ctcaaaatca gccatatcac caaaaagagg atccactgcc atataatctg aaatatcgta
    40021 accattatcc cgttgagggc ttggatagaa tggattgagc cagaccatat ccacacctag
    40081 tttggctaaa tagggaattt tttcgataat cccacggaaa tccccaatac cgttttcagt
    40141 ggtgtctttg taagattttg gatagatttg atagactact tttcctttat caagtgtcat
    40201 ctgtttctcc ttttctgata aaagggagga agcagtcttc cgtccctatt tgtgctattt
    40261 caattatact caatgaaaat caaagaacaa actaggaagc tagccacagg ttgctcaaaa
    40321 cactattttg aggttgcaga tagagctgac gtggtttgaa gagattttcg aagagtatta
    40381 gattcgtgta gcgaccatga gagatgctcc agcttggatc gttgtcggat aagttccggg
    40441 aatagtcgct gtataagcat cttggttggt gatgataaca ggagtttctg tcaccagacc
    40501 tgcagcctta atgacatcca tatcaaaacg aatcagttgc tgaccaactg taacgtgatc
    40561 tccttggact acaagacttt caaaaccttt gccatcaaga cctactgtat ccataccgat
    40621 gtggatgagc aattcaactc cctcgtcaga gacaatgccg atggcatgct tggtagggaa
    40681 aagaaccgtc actgtcccat taactggaga ggtcaactca ccttggcttg gttcaatgac
    40741 cagaccttgc cccatgacac ctgatgcaaa aataggatcc gtcgcttgac tcaattcttt
    40801 cacttggcca gttagtgggc tgataatttc taccgaagta agttctactg gttcatggtt
    40861 cacaaattct gcttcttctt gagcaacgaa ttctgcctgc aagttcgtat cgccctctgt
    40921 ttttgtaaag agaccagcct tgcggaagaa gaaagtcaag agcattggaa caacaatcgc
    40981 aactagcata gttcctgcaa atggcagcat gtattgaggt tgaatagaga gaatacctgg
    41041 caaaccaccg ataccaatag aagccgcagt tacattaaaa gtaacggata acatgcctgc
    41101 aagggctgaa ccagtcatcc cagcaacaaa tggataaata tattttacgt taaccccaaa
    41161 aagagctggt tctgtaacac cgagataggc tgaaatggtt gcaggaagtg aaacctgagc
    41221 ctcacgctca tcatggcgat gcatgaaata ataggcaaac acggctgagc cttgagcaat
    41281 attagaaaga gcaatcattg gccagagggc agtgccacca gcatccgcaa tcaattgtgt
    41341 atcaatggca ttggtcatat ggtgcagacc tgtgatgaca aatggagcgt agagggcacc
    41401 aaaaattgca ccgaagagcc atttaactgg accagttaaa cctgccaaga caactgatga
    41461 aagtccttgt ccaattgtcc aaccgattgg tcccaaaaca gtatgagcca aaatcaaggc
    41521 tggaatcaat gacaaaaaag gtacaaaaat catggaaatg acttctggga tatgtttgcg
    41581 ccagaaaatt tcaagataag acagactcaa acctgcaagc aaggctggga taacttgggc
    41641 ttggtaacca atacgattaa cagtaaaata accaaaattc caaacccagt ttgctgcgat
    41701 atcagctgct ggcgttgaag caaccgcata ggcattgagc aactgaggcg ataccaaaca
    41761 gattccgaga acaattccca aaatttggct ggttcccatc ttacgagaaa cagaccaagt
    41821 aatccctact ggtaagaact ggaagatagc ttcaccaggc aaccagagga agtgattaac
    41881 ccctgcccaa aactgagagg attctgtgat ggtcttgcca tccaacatcg accaatggac
    41941 accttccaag acattacgga aaccgaggat caatccacca acaatcaaag ctggaataat
    42001 cggagtaaag atttccgcca gagtggtcat aacacgttgg accacgtttt gattactctt
    42061 agctgcagac ttggctgctt ctttagaaac accctcaata cctgaaacgg ctgtaaaatc
    42121 attataaaag atgggcacgt catttccaat gattacctga aattgacctg catttgtaaa
    42181 agttccttta acagctggaa ttgactcgat agctttaaca ttagccttct tatcatctcc
    42241 taaaacaaag cgcatccgtg tcgcacagtg agttacggca gtcacatttt ctttgcctcc
    42301 aattgcctga agcagatctt tggcttcttg ttcaaatttt cccatttgat tctccttata
    42361 cttgtcaaag caagtttgat ttgataagta tattgtaaac gataccaaac ttgtctgcaa
    42421 cttgtttggt ataaaaaggg tgtttttttg taaattttct agcacttgta tggtaaaata
    42481 gatacaggtg ttcattaaac tagactaaaa acctatttaa gcaggcaaaa tgaagaaata
    42541 ccaacaatta tttaagcaaa tccaagaaac cattcaaaac gagacttacg ctgtcggaga
    42601 tttccttcct agcgagcacg accttatgga gcaatatcaa gtgagtcgtg ataccgtccg
    42661 aaaggccctg tctctcctcc aagaggaagg attgatcaaa aagataagag ggcaaggttc
    42721 tcaagtcgtc aaagaagaaa ccgtcaattt ccctgtatcc aacctaacca gctaccaaga
    42781 actagttaaa gaacttggac tgcgctctaa aaccaacgtg gtcagtctgg acaagattat
    42841 tattgataaa aaatcctcac tgataaccgg tttcccagag tttcggatgg tttggaaggt
    42901 ggtccgccag cgtgtggtgg atgatctggt atccgttctg gatacagact atctggatat
    42961 ggaactcatc ccaaatctca ctcgccaaat tgctgagcag tctatctatt cttatataga
    43021 aaatggcctc aaactcctta ttgattatgc tcagaaggaa atcaccattg accactcaag
    43081 cgaccgagac aagattctca tggacattgg caaagaccct tatgtcgttt cgattaaatc
    43141 aaaagtctat ctccaagacg gacgccaatt tcagtttacc gaaagtcgcc ataagttaga
    43201 gaaatttaga tttgtagatt ttgcaaaacg caagaaataa aagactgaga caccagatct
    43261 cagccttttt cggctctata atatttgtag tgggtaaccc cccctataga tattatggag
    43321 cctattttat tgtagaaaaa aagtcccata agatctataa tgaaaagcga caaaacaact
    43381 cattagaaag a
//
LOCUS       DAVHIZ010000013        43156 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.013, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000013 DAVHIZ010000000
VERSION     DAVHIZ010000013.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 43156)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 43156)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..43156
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.013"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..169)
                     /locus_tag="VVO18_000702"
     CDS             complement(<1..169)
                     /locus_tag="VVO18_000702"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEU5585902.1"
                     /translation="MNITNLFSIKTGCDETDRQLQKLFFQLDLQLGELTDQLRKLDSN
                     FVPRSQFVDTLD"
     gene            complement(407..643)
                     /locus_tag="VVO18_000703"
     CDS             complement(407..643)
                     /locus_tag="VVO18_000703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585903.1"
                     /translation="MLADQNKADWSYDENAVINIYDDANFEDGRLHMTFEQFFKLAQI
                     AREEGLEIHSPFERAGATKSARYIAKWILRNKKY"
     gene            complement(750..1772)
                     /gene="ilvC"
                     /locus_tag="VVO18_000704"
     CDS             complement(750..1772)
                     /gene="ilvC"
                     /locus_tag="VVO18_000704"
                     /EC_number="1.1.1.86"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEU5585904.1"
                     /translation="MTVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGRDV
                     IIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGN
                     AVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTYEEGFGVPALYAVYQDATGN
                     AKNIAMDWCKGVGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIEAGFEVLTEAG
                     YAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEYGDYVSGPRVITEQVKENMK
                     AVLADIQNGKFANDFVNDYKAGRPKLTAYREQAANLEIEKVGAELRKAMPFVGKNDDD
                     AFKIYN"
     gene            complement(1838..2314)
                     /gene="ilvN"
                     /locus_tag="VVO18_000705"
     CDS             complement(1838..2314)
                     /gene="ilvN"
                     /locus_tag="VVO18_000705"
                     /EC_number="2.2.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002927678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase small subunit"
                     /protein_id="HEU5585905.1"
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATEDPNVS
                     RITIIIDVASHDEVEQIIKQLNRQIDVIRIRDITDKPHLEREVILVKMSAPAEKRAEI
                     LAIIQPFRATVVDVAPSSITIQMTGNAEKSEALLRVIRPYGIRNIARTGATGFTRD"
     gene            complement(2307..4007)
                     /locus_tag="VVO18_000706"
     CDS             complement(2307..4007)
                     /locus_tag="VVO18_000706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate synthase large subunit"
                     /protein_id="HEU5585906.1"
                     /translation="MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIY
                     NFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPL
                     LVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRP
                     GPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAG
                     GGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTE
                     ADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQM
                     LLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDV
                     GQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQM
                     TNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAY
                     GIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
                     "
     gene            complement(4207..5874)
                     /locus_tag="VVO18_000707"
     CDS             complement(4207..5874)
                     /locus_tag="VVO18_000707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DAK2 domain-containing protein"
                     /protein_id="HEU5585907.1"
                     /translation="MSKITTSLFQEMVQAASTRLNKQAEYVNSLNVFPVPDGDTGTNM
                     GMTIENGAKEVADKPASTVGEVASILAKGLLMGARGNSGVITSQLFRGFSQAIKDKDE
                     LTGQDLALAFQSGVEVAYKAVMKPVEGTILTVSRGAAIGAKKKAEQTDDAVEVMRAAL
                     EGAKTALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFVATPANM
                     SEMINVEHHKSVAGHVATEDITFGYCTEIMVALKQGPTYAKDFDYDEFRNYLDELGDS
                     LLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVDNMRNQHEAQVEKEATQVIKS
                     AEEKEYALIAVVAGKGLADIFCSQGVDYVIEGGQTMNPSTEDFIKAVEQVNARNIIFL
                     PNNKNIFMAAQSAAEVLEQPAVVVEARTLPQGMTSLLAFDPSKSIEENQERMTAALSD
                     VVSGSVTTAVRDTTIDGLEIHENDNLGMVDGKILVSNPDMHQTLTETLKHMLDEDSEI
                     VTFYVGEDGSEELANEIAQEIVEEFEDVEVEIHQGQQPVYPYLFSVE"
     gene            complement(5877..6242)
                     /locus_tag="VVO18_000708"
     CDS             complement(5877..6242)
                     /locus_tag="VVO18_000708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU5585908.1"
                     /translation="MTVKINTKDGQIELTDEVIATVVGGAATEIFGVVGMASKNALKD
                     NFQALLGKENYSKGVVVKAAEDGSIAVDVYTVLSYGTKISEVSKNIQERVAFSLENQL
                     GITAQTVNVYIQNIKVVGE"
     gene            complement(6399..6587)
                     /locus_tag="VVO18_000709"
     CDS             complement(6399..6587)
                     /locus_tag="VVO18_000709"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008536053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L28"
                     /protein_id="HEU5585909.1"
                     /translation="MAKVCYFTGRKTVSGNNRSHAMNQTKRAVKPNLQKVTVLIDGKP
                     KKVWASARALKSGKVERV"
     gene            complement(6703..6879)
                     /locus_tag="VVO18_000710"
     CDS             complement(6703..6879)
                     /locus_tag="VVO18_000710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
                     /protein_id="HEU5585910.1"
                     /translation="MDLDIVVRKSIDELWDLDLTAIPLAAVRDDFYTHNFNSGVLLIN
                     NGMWRAENVTQDLI"
     gene            complement(6990..7188)
                     /locus_tag="VVO18_000711"
                     /pseudo
     CDS             complement(6990..7188)
                     /locus_tag="VVO18_000711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808887.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyl transferase family 8"
     gene            complement(7615..9159)
                     /locus_tag="VVO18_000712"
     CDS             complement(7615..9159)
                     /locus_tag="VVO18_000712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011681503.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 3"
                     /protein_id="HEU5585911.1"
                     /translation="MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVK
                     GKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMA
                     VDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILG
                     IASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDD
                     IELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLEIFLKFAPEPHGHKKTDGE
                     IVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNV
                     TQFMAESRENVINAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVS
                     AKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTGEYMLGAVGQLQFEVFKHRMEGEYNAE
                     VVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDV
                     ELEEKM"
     gene            9372..9674
                     /gene="gatC"
                     /locus_tag="VVO18_000713"
     CDS             9372..9674
                     /gene="gatC"
                     /locus_tag="VVO18_000713"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatC"
                     /protein_id="HEU5585912.1"
                     /translation="MKITQEEVTHVANLSKLRFSEEETAAFATTLSKIVDMVELLGEV
                     DTTGVAPTTTMADRKTVLRPDVAEEGIDRDRLFKNVPEKDNYYIKVPAILDNGGDA"
     gene            9674..11140
                     /gene="gatA"
                     /locus_tag="VVO18_000714"
     CDS             9674..11140
                     /gene="gatA"
                     /locus_tag="VVO18_000714"
                     /EC_number="6.3.5.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatA"
                     /protein_id="HEU5585913.1"
                     /translation="MTFNNKTIEELHNLLVSKEISATELTQATLENIKSREEALNSFV
                     TIAEEQALVQAKAIDEAGIDADNVLSGIPLAVKDNISTDGILTTAASKMLYNYEPIFD
                     ATAVANAKTKGMIVVGKTNMDEFAMGGSGETSHYGATKNAWDHSKVPGGSSSGSAAAV
                     ASGQVRLSLGSDTGGSIRQPAAFNGIVGLKPTYGTVSRFGLIAFGSSLDQIGPFAPTV
                     KENALLLNAIASEDAKDSTSAPVRIADFTSKIGQDIKGMKIALPKEYLGEGINPEVKE
                     TILNAAKHFEKLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRAEDA
                     TNLDEIYVNSRSQGFGEEVKRRIMLGTFSLSSGYYDAYYKKAGQVRTLIIQDFEKVFA
                     DYDLILGPTAPSVAYDLDSLNHDPVAMYLADLLTIPVNLAGLPGISIPAGFSQGLPVG
                     LQLIGPKHSEETIYQVAAAFEATTGYHKQQPVIFGGDN"
     gene            11140..12582
                     /gene="gatB"
                     /locus_tag="VVO18_000715"
     CDS             11140..12582
                     /gene="gatB"
                     /locus_tag="VVO18_000715"
                     /EC_number="6.3.5.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="HEU5585914.1"
                     /translation="MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSF
                     PGVLPVLNKGVVDAGIKAALALNMDIHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYN
                     GWIEVELEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMR
                     SPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNS
                     FSNVRKGLEYEVQRQAEILRSGGQIRQETRRYDEANKATILMRVKEGAADYRYFPEPD
                     LPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDASQLTANKVTSDFFEKAVA
                     LGGDAKQVSNWLQGEVAQFLNAEGKTLEQIELTPENLVEMIAIIEDGTISSKIAKKVF
                     VHLAKNGGGAREYVEKAGMVQISDPAVLIPIIHQVFADNEAAVADFKSGKRNADKAFT
                     GFLMKATKGQANPQVALKLLAQELAKLKEN"
     gene            12706..13749
                     /locus_tag="VVO18_000716"
     CDS             12706..13749
                     /locus_tag="VVO18_000716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000224421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2,3-butanediol dehydrogenase"
                     /protein_id="HEU5585915.1"
                     /translation="MATMKAARWHAAKDVRIQEIEVPEVLPHQVKVAVKFTGICGTDL
                     HEFLDGPIFIPTDEHVYSGQKAPVTLGHEFSGEIIEVGSDVTRVKVGDRVAVEPILAK
                     NNLVGDYNLDPNLNFVGLAADGGFAKYCVLDGDLVHVIPDSLSYEQAALTEPAAVAVY
                     AVRQSSLKAGDTAVVFGLGPIGLLIVEALRAAGASKIYAVELSPERQAKAEELGAIVV
                     RPEEGETAVEAIHRLTNGGVDVSYEVTGVPVVLGQALAAVHKAGECMVVSIWEREANI
                     NPNEFAIQEKTLKGIIAYRHIFPKVLELMEQGYFSAEKLVTKKIKLENIVEEDFIELT
                     QDKSQIKILVEPE"
     gene            complement(13885..13968)
                     /locus_tag="VVO18_000717"
                     /pseudo
     CDS             complement(13885..13968)
                     /locus_tag="VVO18_000717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            14127..14687
                     /gene="efp"
                     /locus_tag="VVO18_000718"
     CDS             14127..14687
                     /gene="efp"
                     /locus_tag="VVO18_000718"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000568636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor P"
                     /protein_id="HEU5585916.1"
                     /translation="MIEASKLKAGMTFETADGKLIRVLEASHHKPGKGNTIMRMKLRD
                     VRTGSTFDTSYRPEEKFEQAIIETVPAQYLYKMDDTAYFMNTETYDQYEIPVVNVENE
                     LLYILENSDVKIQFYGTEVIGVTVPTTVELTVAETQPSIKGATVTGSGKPATMETGLV
                     VNVPDFIEAGQKLVINTAEGTYVSRA"
     gene            14709..15098
                     /locus_tag="VVO18_000719"
     CDS             14709..15098
                     /locus_tag="VVO18_000719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU5585917.1"
                     /translation="MGIEEQLGEIVIAPRVLEKIIAIATAKVEGVHSFSNRSVSDTLS
                     KLSLGRGIYLKNVDEELTADIYLYLEYGVKVPKVAVAIQKAVKDAVRNMADVELAAIN
                     IHVAGIVPDKTPKPELKDLFDEDFLND"
     gene            15091..15513
                     /gene="nusB"
                     /locus_tag="VVO18_000720"
     CDS             15091..15513
                     /gene="nusB"
                     /locus_tag="VVO18_000720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000203663.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antitermination factor NusB"
                     /protein_id="HEU5585918.1"
                     /translation="MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDT
                     DVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFD
                     TPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ"
     gene            complement(15563..15799)
                     /locus_tag="VVO18_000721"
     CDS             complement(15563..15799)
                     /locus_tag="VVO18_000721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5585919.1"
                     /translation="MDVILSAIIFGISHLILSHRDPISLLYYSLIGFFFALVYRSTDN
                     LRLTILCHSFFNFLNHAKPIWIFVYNYIYYHFFR"
     gene            complement(16281..16466)
                     /gene="briC"
                     /locus_tag="VVO18_000722"
     CDS             complement(16281..16466)
                     /gene="briC"
                     /locus_tag="VVO18_000722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biofilm-regulating peptide BriC"
                     /protein_id="HEU5585920.1"
                     /translation="MTGTETFTVISTEDLEQTSSGLAVWEDGYSRWLYYREFAPYMRQ
                     GALNSYIDAWKYGFRTG"
     gene            complement(16729..17496)
                     /locus_tag="VVO18_000723"
     CDS             complement(16729..17496)
                     /locus_tag="VVO18_000723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001017399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyl transferase
                     subunit alpha"
                     /protein_id="HEU5585921.1"
                     /translation="MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAV
                     VGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVT
                     FINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRV
                     WMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSS
                     KELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY"
     gene            complement(17493..18359)
                     /locus_tag="VVO18_000724"
     CDS             complement(17493..18359)
                     /locus_tag="VVO18_000724"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001173351.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit beta"
                     /protein_id="HEU5585922.1"
                     /translation="MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTI
                     YQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLA
                     SMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKL
                     PVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAM
                     EGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTI
                     ASLVRLHGGSPR"
     gene            complement(18396..19763)
                     /gene="accC"
                     /locus_tag="VVO18_000725"
     CDS             complement(18396..19763)
                     /gene="accC"
                     /locus_tag="VVO18_000725"
                     /EC_number="6.3.4.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000488661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="HEU5585923.1"
                     /translation="MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLL
                     ADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKF
                     IGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
                     AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEH
                     GHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEF
                     LLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGH
                     AIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKII
                     VHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPK
                     YQEKE"
     gene            complement(19775..20197)
                     /gene="fabZ"
                     /locus_tag="VVO18_000726"
     CDS             complement(19775..20197)
                     /gene="fabZ"
                     /locus_tag="VVO18_000726"
                     /EC_number="4.2.1.59"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="HEU5585924.1"
                     /translation="MIDIQGIKEALPHRYPMLLVDRVLEVSEDTIVAIKNVTINEPFF
                     NGHFPQYPVMPGVLIMEALAQTAGVLELSKPENKGKLVFYAGMDKVKFKKQVVPGDQL
                     VMTATFVKRRGTIAVVEAKAEVDGKLAASGILTFAIGN"
     gene            complement(20194..20679)
                     /locus_tag="VVO18_000727"
     CDS             complement(20194..20679)
                     /locus_tag="VVO18_000727"
                     /EC_number="6.4.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001052236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="HEU5585925.1"
                     /translation="MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVA
                     TQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVATEGNLVESPLVGVVYLAAGP
                     DKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRI
                     K"
     gene            complement(20682..21917)
                     /gene="fabF"
                     /locus_tag="VVO18_000728"
     CDS             complement(20682..21917)
                     /gene="fabF"
                     /locus_tag="VVO18_000728"
                     /EC_number="2.3.1.179"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="HEU5585926.1"
                     /translation="MKLNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHS
                     DFDVHNAAEIQDFPFDKYFVKKDTNRFDNYSLYALYAAQEAVNHANLDVEALNRDRFG
                     VIVASGIGGIKEIEDQVLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSI
                     NTACSSSNDAIGDAFRSIKFGFQDVMLVGGTEASITPFAIAGFQALTALSTTEDPTRA
                     SIPFDKDRNGFVMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEG
                     QGAIKAIKLALEEAEISPEQVAYVNAHGTSTPANEKGESGAIVAVLGKEVPVSSTKSF
                     TGHLLGAAGAVEAIVTIEAMRHNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISN
                     TFGFGGHNAVLAFKRWENR"
     gene            complement(21939..22670)
                     /gene="fabG"
                     /locus_tag="VVO18_000729"
     CDS             complement(21939..22670)
                     /gene="fabG"
                     /locus_tag="VVO18_000729"
                     /EC_number="1.1.1.100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier-protein] reductase"
                     /protein_id="HEU5585927.1"
                     /translation="MKLEHKNIFITGSSRGIGLAIAHKFAQAGANIVLNSRGAISEEL
                     LSEFSNYGIKVVPISGDVSDFADAKRMIDQAIAELGSVDVLVNNAGITQDTLMLKMTE
                     ADFEKVLKVNLTGAFNMTQSVLKPMMKAREGAIINMSSVVGLMGNIGQANYAASKAGL
                     IGFTKSVAREVASRNIRVNVIAPGMIESDMTAILSDKIKEATLAQIPMKEFGQAEQVA
                     DLTVFLAGQDYLTGQVIAIDGGLSM"
     gene            complement(22704..23624)
                     /gene="fabD"
                     /locus_tag="VVO18_000730"
     CDS             complement(22704..23624)
                     /gene="fabD"
                     /locus_tag="VVO18_000730"
                     /EC_number="2.3.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ACP S-malonyltransferase"
                     /protein_id="HEU5585928.1"
                     /translation="MTKTAFLFAGQGAQYLGMGRDFYDQYPIVKETIDRASQVLGYDL
                     RYLIDTEEDKLNQTRYTQPAILATSVAIYRLLQEKGYQPDMVAGLSLGEYSALVASGA
                     LDFEDAVALVAKRGAYMEEATPADSGKMVAVLNTPVEVIEEACQKASELGVVTPANYN
                     TPAQIVIAGEVVAVDRAVELLQEAGAKRLIPLKVSGPFHTALLEPASQKLAETLAQVS
                     FSDFTCPLVGNTEAAVMQKEDIAQLLTRQVKEPVRFYESIGVMQEAGISNFIEIGPGK
                     VLSGFVKKIDQTAHLAHVEDQASLVALLEK"
     gene            complement(23617..24591)
                     /gene="fabK"
                     /locus_tag="VVO18_000731"
     CDS             complement(23617..24591)
                     /gene="fabK"
                     /locus_tag="VVO18_000731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-[acyl-carrier-protein] reductase FabK"
                     /protein_id="HEU5585929.1"
                     /translation="MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGG
                     NAPKEVVKANIDKIKSLTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKY
                     MERFHEAGIIVIPVVPSVALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATA
                     ISIPVIAAGGIADGEGAAAGFMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDT
                     TISAQHFGHAVRAIKNQLTRDFELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVD
                     GGSVMAGQIAGLVSKEETAEEILKDLYYGAAKKIQEEASRWTGVVRND"
     gene            complement(24710..24934)
                     /locus_tag="VVO18_000732"
     CDS             complement(24710..24934)
                     /locus_tag="VVO18_000732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl carrier protein"
                     /protein_id="HEU5585930.1"
                     /translation="MAVFEKVQEIIVEELGKDASEVTLESTFDDLDADSLDLFQVISE
                     IEDAFDIQIEAENDLKTVGDLVAYVEEQAK"
     gene            complement(24994..25968)
                     /locus_tag="VVO18_000733"
     CDS             complement(24994..25968)
                     /locus_tag="VVO18_000733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="HEU5585931.1"
                     /translation="MAFAKISQVAHYVPEQVVTNHDLAQIMDTNDEWISSRTGIRQRH
                     ISRTESTSDLATEVAKKLMAKAGITGEELDFIILATITPDSMMPSTAARVQANIGANK
                     AFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLSKAVDWSDRSTAVLFGDG
                     AGGVLLEASEQEHFLAESLNSDGSRSECLTYGHSGLHSPFSDQESADSFLKMDGRTVF
                     DFAIRDVAKSIKQTIDESPIEVTDLDYLLLHQANDRILDKMARKIGVDRAKLPANMME
                     YGNTSAASIPILLSECVEQGLIPLDGSQTVLLSGFGGGLTWGTLILTI"
     gene            complement(25968..26402)
                     /locus_tag="VVO18_000734"
     CDS             complement(25968..26402)
                     /locus_tag="VVO18_000734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU5585932.1"
                     /translation="MDYQRINEYLTSIFNNVLVIEEVNLRGSRFKDISIKEMHTIDVI
                     GKAPDVTPSQVSKELMVTLGTVTTSLNNLERKGYIERVRSEQDRRVVHLHLTKKGHLI
                     HRLHKRFHKAMVEKIIDGMSEEEIAVMGKGLTNLYQFLEDLK"
     gene            complement(26496..27281)
                     /locus_tag="VVO18_000735"
     CDS             complement(26496..27281)
                     /locus_tag="VVO18_000735"
                     /EC_number="4.2.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase"
                     /protein_id="HEU5585933.1"
                     /translation="MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEEN
                     PAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVL
                     MEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAA
                     QLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWES
                     QFKDWQGYATLELNLQKSLAQTEDFKEGVRAHSERRRPKFTGK"
     gene            27606..28970
                     /locus_tag="VVO18_000736"
     CDS             27606..28970
                     /locus_tag="VVO18_000736"
                     /EC_number="2.7.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251870.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate kinase"
                     /protein_id="HEU5585934.1"
                     /translation="MKVVKFGGSSLASASQLEKVLNIVKSDSERRFVVVSAPGKRNAE
                     DTKVTDALIKYYRDYVAGNDISKSQSWIIDRYAAMVSELGLKPAVLEKISKSIHALAT
                     LPIEENEFLYDTFLAAGENNNAKLIAAYFNQNGIDARYMHPREAGIVVTSEPGHARII
                     PSSYDKIEELTNTNEVLVIPGFFGVTKENQICTFSRGGSDITGSIIAAGVKADLYENF
                     TDVDGIFAAHPGIIHQPHSIPELTYREMRELAYAGFSVLHDEALLPAYRGKIPLVIKN
                     TNNPDHPGTRIVLKHSNDEFPVVGIAGDSGFVSINMSKYLMNREVGFGRKVLQILEEL
                     NIGWEHMPTGIDDLSIILRSRQLTPIKEEEILRQLVQKAKVDHAEIEHDLSIIMIVGE
                     KMKSHIGVTATATRALSENKINIQMMSQGSSEVSIMFVVNKDQEKAAIKALYNAFFGE
                     SKED"
     gene            28973..29344
                     /locus_tag="VVO18_000737"
     CDS             28973..29344
                     /locus_tag="VVO18_000737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000079352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF956 family protein"
                     /protein_id="HEU5585935.1"
                     /translation="MAQSLNKTVLLSTTGTSYLSIAGKVGKFLVGDQALEFYPDVNVE
                     QFIQIPWSHINQIGANVTGCKISRHFEVFTDKGKFLFASKDSGAILKIAREKLGNDKV
                     VKLPTLIQTISQKFKNLFAKK"
     gene            29558..30832
                     /gene="serS"
                     /locus_tag="VVO18_000738"
     CDS             29558..30832
                     /gene="serS"
                     /locus_tag="VVO18_000738"
                     /EC_number="6.1.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884256.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine--tRNA ligase"
                     /protein_id="HEU5585936.1"
                     /translation="MLDIKRIRTDFEAVAEKLATRGVDAAVLNEMKEIDAKRRNILVK
                     VETLKAERNTVSAEIAQAKRNKENTDDKIAAMQNLSAEVKALDAELAEIDAKLTEFTT
                     TLPNIPADSVPVGADEDDNVEVRRWGTPREFDFEPKAHWDLGEDLGILDWERGGKVTG
                     ARFLFYKGLGARLERAIYNFMLDEHGKEGYTEVITPYIVNHDSMFGTGQYPKFKEDTF
                     ELSDTNFVLIPTAEVPLTNYYRDEILDGKDLPIYFTAMSPSFRSEAGSAGRDTRGLIR
                     LHQFHKVEMVKFAKPEESYEELEKMTANAENILQKLNLPYRVVALSTGDMGFSAAKTY
                     DLEVWIPAQNNYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTV
                     AAILENYQNEDGSVTIPEALRPYMGGAEVIKP"
     gene            complement(30857..31756)
                     /locus_tag="VVO18_000739"
     CDS             complement(30857..31756)
                     /locus_tag="VVO18_000739"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000735961.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TDT family transporter"
                     /protein_id="HEU5585937.1"
                     /translation="MKKLPLVFSGCLLGLAGAGNLILDTLPVLSHLFSLTGLVLWIYF
                     LILHLFNWKETKQELTKPPLLSGMATFPMAGMILSTYVFRVFSYLPLVAQGIWWFSFL
                     LDLTLIAGFTIKFACPGRRVHATPSWTVLYVGIAVAALTYPLVGIIEIAYATLSFGFL
                     LTFYLYPLIYSDLKKHPLPLALLGQEGIYCAPFSLLLASLVRVGGTSLPTWVLIVMIL
                     ASQSFFFFVLTRLPNILKQGFQPAFSALTFPTIITATSLKMTQGILKLPFLDYLVLAE
                     TIICLTILFFVLGAYLIWLRKKV"
     gene            complement(31866..32414)
                     /locus_tag="VVO18_000740"
     CDS             complement(31866..32414)
                     /locus_tag="VVO18_000740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000206764.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="HEU5585938.1"
                     /translation="MTTFTIHTVESAPAEVKEILETVEKDNNGYIPNLIGLLANAPTV
                     LEAYQIVSSIHRRNSLTPVEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMNDDLIQA
                     LRNRTPIETDPKLDTLAKFTLAVINTKGRVGDEALSEFLEAGYTQQNALDVVFGVSLA
                     ILCNYANNLANTPINPELQPYA"
     gene            complement(32632..33948)
                     /locus_tag="VVO18_000741"
     CDS             complement(32632..33948)
                     /locus_tag="VVO18_000741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium:alanine symporter family protein"
                     /protein_id="HEU5585939.1"
                     /translation="MLELLKSIDAFAWGPPLLILLVGTGIYLTIRLGLLQVLRLPKAF
                     QLIFIQDKGHGDVSSFAALCTALASTVGTGNIIGVATAIKVGGPGALFWMWMAAFFGM
                     ATKYAEGLLAIKYRTKDDHGAVAGGPMHYILLGMGEKWRPLAVLFAVAGVLVALLGIG
                     TFTQVNSIAESIQNTTTISPAITALVLSVFVAIAVFGGLKSISKVSTTVVPFMAIIYI
                     LGTLTVIFFNIGKIPGTIALVFTSAFSPLAAVGGFAGASVRMAIQNGVARGVFSNESG
                     LGSAPIAAAKTNEPVEQGLISMTGTFIDTLIICTLTGLTILVTGVWSGDLNGVALTQS
                     AFSTVFSHFGPALLTIFLVLFAFTTILGWNYYGERCFEFLFGVRFIWLYRVVFVLMVL
                     LGGFIELDMVWIIADIVNALMALPNLIALLVLSPVVIAETKKYFDK"
     regulatory      complement(34039..34127)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00504"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="glycine riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="glycine"
                     /db_xref="RFAM:RF00504"
     gene            complement(34291..36627)
                     /locus_tag="VVO18_000742"
     CDS             complement(34291..36627)
                     /locus_tag="VVO18_000742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease MutS2"
                     /protein_id="HEU5585940.1"
                     /translation="MNKKILETLEFDKVKALFEPHLLTEQGLEQLRQLAPTAKADKIK
                     QAFAEMKEMQALFVEQPHFTILSTKEIAGVCKRLEMGADLNIEEFLLLKRVLLASREL
                     QSFYANLENVSLEELALWFEKLHDFPQLQGNLQAFNDAGFIENFASEELARIRRKIHD
                     SESQVRDVLQDLLKQKAQMLTEGIVASRNGRQVLPVKNTYRNKIAGVVHDISASGNTV
                     YIEPREVVKLSEEIASLRADERYEMLRILQEISERVRPHATEIANDAWIIGHLDLIRA
                     KVRFIQERQAVVPQLSENQEIQLLHVCHPLVKNAVANDVHFGQDLTAIVITGPNTGGK
                     TIMLKTLGLTQVMAQSGLPILADRGSRVGIFEEIFADIGDEQSIEQSLSTFSSHMTNI
                     VDILGKVNQHSLLLLDELGAGTDPQEGAALAMAILEDLRLRQIKTMATTHYPELKAYG
                     IETAFVQNASMEFDTATLRPTYRFMQGVPGRSNAFEIAKRLGLSEVIVGDASQQIDQD
                     NDVNRIIEQLEEQTLESRKRLDNIREVEQENLKMNRALKKLYNELNREKETELNKARE
                     QAAEIVDMALSESDQILKNLHSKSQLKPHEIIEAKAKLKKLAPEKVDLSKNKVLQKAK
                     KKRAPKVGDDIVVLSYGQRGTLTSQLKDGRWEAQVGLIKMTLEEKEFDLVQAQQEKPV
                     KKKQVNVVKRTSGRGPQARLDLRGKRYEEAMNELDIFIDQALLNNMAQVDIIHGIGTG
                     VIREGVTKYLQRNKHVKSFGYAPQNAGGSGATIVTFKG"
     gene            complement(36731..37279)
                     /locus_tag="VVO18_000743"
     CDS             complement(36731..37279)
                     /locus_tag="VVO18_000743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000622948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CvpA family protein"
                     /protein_id="HEU5585941.1"
                     /translation="MISFLLLLVLVWGFYIGYRRGLLLQVYYLISAMASAFMAGQFYK
                     GLGEQFHLLLPYANSQEGQGTFFFPSDQLFQLDKVFYAGIGYLLVFGIVYSIGRLLGL
                     LLHLIPSKKLGGKLFQVSAGILSMLVTLFVLQMALTILATIPMAVIQNPLEKSIVAKH
                     IIQSIPITTSWLKQIWVTNLIG"
     gene            complement(37276..37578)
                     /gene="zapA"
                     /locus_tag="VVO18_000744"
     CDS             complement(37276..37578)
                     /gene="zapA"
                     /locus_tag="VVO18_000744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150060.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein ZapA"
                     /protein_id="HEU5585942.1"
                     /translation="MANLNRFKFTFGKKSLTLTSEHDNLFMEEIAKVATEKYQAIKEQ
                     MPSADDETIALLLAVNCLSTQLSREIEFDDKEQELEELRHKLVTCKQEQSKIEDSL"
     gene            37665..38546
                     /locus_tag="VVO18_000745"
     CDS             37665..38546
                     /locus_tag="VVO18_000745"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000146880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HIII"
                     /protein_id="HEU5585943.1"
                     /translation="MASITLTPSEKDIQAFLEHYQTSLAPSKNPYIRYFLKLPQATVS
                     IYTSGKILLQGEGAEKYASFFGYQAVEQTSGQNLPLIGTDEVGNGSYFGGLAVVAAFV
                     TPDQHDFLRKLGVGDSKTLTDQKIRQIAPILKEKIQHQALLLSPSKYNEVIGNRYNAV
                     SVKVALHNQAIYLLLQKGVQPEKIVIDAFTSAKNYDKYLAQETNRFSNPISLEEKAEG
                     KYLAVAVSSVIARDLFLENLENLGRELGYQLPSGAGTASDKVASQILQAYGMQGLNFC
                     AKLHFKNTEKAKKRLER"
     gene            38550..39164
                     /gene="lepB"
                     /locus_tag="VVO18_000746"
     CDS             38550..39164
                     /gene="lepB"
                     /locus_tag="VVO18_000746"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="HEU5585944.1"
                     /translation="MNSFKNFLKEWGLFLLILSLLALSRIFFWSNVRVEGHSMDPTLA
                     DGEILFVVKHLPIDRFDIVVAHEEDGNKDIVKRVIGMPGDTIRYENDKLYINDKETDE
                     PYLADYIKRFKDDKLQSTYSGKGFEGNKGTFFRSIAQKAQAFTVDVNYNTNFSFTVPE
                     GEYLLLGDDRLVSSDSRHVGTFKAKDITGEAKFRFWPITRIGTF"
     gene            39292..41658
                     /locus_tag="VVO18_000747"
     CDS             39292..41658
                     /locus_tag="VVO18_000747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent RecD-like DNA helicase"
                     /protein_id="HEU5585945.1"
                     /translation="MEVYFSGTIERIIFENPSNFYRILLLEIDDTDAEDFDDFEIIVT
                     GTMADVIEGEDYTFWGQIVQHSKYGEQLQISRYDRAKPTSKGLVKYFSSSHFKGIGLK
                     TAQKIVDTYGENTIDEILQHPEKLEGIVGLSAKNREAFVSTLRLNYGTEMILAKLANY
                     GIPNKLAFQIQDFYKEETLDVVENYPYQLVEDIKGLGFTIADQLAEELGIESQAPERF
                     RAGLVHSLFQACMETGDTYVEVRDLLEQTLTLLESSRPVELDPSQVAQELSYLIEEDK
                     VQQIDTKIFDNSLFFAEEGIRSHLVRILEKGKQKSHDLETIQKHITTIEEELGIEYDN
                     IQKQAICDAIQNKVFILTGGPGTGKTTVINGIIAVYALLEGLDLRKKSNLPILLAAPT
                     GRAARRMNELTGLPSATIHRHLGMTGDDDTSHLEDYLDTDFIIVDEFSMVDTWLANQL
                     FSNISSNSKILIVGDSDQLPSVSPGQVLADLLHIPLIPQTRLEKIYRQSEESTIVTLA
                     SQIRQGILPADFTQKKADRSYFEIASGHIPATIEKILGAALRNGIPARDIQVLAPMYR
                     GTAGIDAINQLMQDLLNPPQKDQLSFEAPQCHYRKGDKVIHLVNDTEINVFNGDLGAI
                     TDLIPGKYTESKQDEIVIDFDGNEVSYPRNEWYKIRLAYAMSIHKSQGSEFPVVILPI
                     TSASRRMLERNLIYTAITRAKSKLILLGELQAFDHATQHIGTARKTYLVERFSDLLKN
                     VEEKQQAVSETVTSSASEQSYILTEENWDRIPAMIGITDTDLKEIFGK"
     gene            complement(41706..42989)
                     /locus_tag="VVO18_000748"
     CDS             complement(41706..42989)
                     /locus_tag="VVO18_000748"
                     /EC_number="5.2.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="trigger factor"
                     /protein_id="HEU5585946.1"
                     /translation="MSVSFENKETNRGVLTFTISQDQIKPELDRVFKSVKKSLNVPGF
                     RKGHLPRPIFDKKFGEESLYQDVMNALLPNAYEAAVKEAGLEVVAQPKIDVTSMEKGQ
                     DWVIAAEVVTKPEVKLGDYKNLEVSVDVEKEVTDADVEERIERERNNLAELVIKEAAA
                     EDGDTVVIDFVGSIDGVEFDGGKGENFSLGLGSGQFIPGFEDQLVGHSAGETVDVIVT
                     FPEDYQAEDLAGKEAKFVTTIHEVKAKEVPALDDELAKDIDEEVETLADLKEKYRKEL
                     AAAKEEAYKDAVEGAAIDTAVENAEIVELPEEMIHEEVHRSVNEFLGNLQRQGINPDM
                     YFQITGTTQEDLHNQYQAEAESRTKTNLVIEAVAKAEGFDASEEEIQKEVEQLAADYN
                     MEVAQVQNLLSADMLKHDITIKKAVELITSTATVK"
BASE COUNT        12521 a         9861 c         8284 g        12490 t
ORIGIN      
        1 aatccaacgt gtctacaaat tgactacgag gaacaaaatt agaatctaat tttcttagtt
       61 gatctgtcaa ttctcccaat tgtaaatcca actgaaaaaa tagtttttgc agttgcctat
      121 cagtttcatc acatcctgtc ttgatagaaa acaaattggt aatattcata tgatttcaac
      181 ccctaaataa gtacatctaa tatcccacga atagctgaag ctaaagtttt cgcagtccag
      241 tcatttaaac ccgattcttt caatccagat gcaataattt gctctatttg atataaaccg
      301 ccatctatcg tctcatttat tctgcgaaga ggaccttcaa tataggataa agcttctccg
      361 aatctaacag ctgatttagg tcctaatgat ttaccaacta tatttgttaa tattttttat
      421 ttctcaaaat ccatttcgct atataacgag cagatttagt cgcaccagct ctctcaaacg
      481 gagaatgaat ttcaagacct tcttctctag ctatttgtgc caatttgaag aattgttcaa
      541 aggtcatatg caacctacca tcttcaaaat tagcatcatc ataaatgtta attacagcat
      601 tttcatcata cgaccaatct gctttatttt ggtctgctag cactattacc gacggtgtaa
      661 ttacattata caactagaac caataataac gatgcaattt ttctcataat ctttttcata
      721 aaatcatctc cagcgctata tatttctaat tagttataga ttttgaatgc atcatcgtcg
      781 tttttaccaa cgaatggcat tgctttacgc aattctgcac caactttttc aatttcaagg
      841 ttagctgctt gttcacggta agcagtcaat tttggacgtc cagctttata gtcatttaca
      901 aagtcatttg caaatttacc attttggatg tctgccaaga cagccttcat attttcttta
      961 acttgttcag tgattacacg tggacctgat acatagtcac cgtattcagc agtgtttgaa
     1021 atagattgac gcattttctt gaatccacct tcgtagatca agtcaacgat caatttcatt
     1081 tcgtgaagaa cttcaaagta agccaattct ggagcgtaac ctgcttctgt caagacttcg
     1141 aaacctgctt cgataagggc agtcaaacca ccacaaagta cagcttgttc accaaacaaa
     1201 tcttcttcag tttcttcttt gtaagttgtt tcaagaagac ctacacgagc cgctccaaca
     1261 cctttacacc agtccatagc aatgttttta gcatttcctg ttgcatcttg gtatactgca
     1321 taaagagctg gaacaccaaa tccttcttcg taagtacgac gtaccaagtg tcctggtcct
     1381 ttaggagcac acatgaagac atctacatcc gcaggaactt tgataaattc aaagtggatg
     1441 ttgaaaccat gggcaaatcc aactgcgttt ccagcttcca agtttggagc gatttctgct
     1501 tcgtacaatt cttgttgaat ttcgtctggc gccaagatca taataacatc agccaactta
     1561 gtagcttctg ctactgtgta agtatcaaat ccatcttctt ttgctttatc aaaagattta
     1621 cctggacgta caccgataat aacgtcacga cctgaatcac gcaagttttg agcatgcgca
     1681 tgcccttgtg aaccataacc gataacggcg atttttttac cgtcaagtgc tgctacttta
     1741 acatcttttt catattccat ttgaactgtc atagcttttc tctcttttct attatttatt
     1801 gccttttagg ctggtttaat aaatttaagt tggattttta atcgcgggta aatccagttg
     1861 cacccgttcg agcaatattg cgaataccgt atgggcgaat gactcgcaat agggcttcgc
     1921 tcttttctgc atttcccgtc atctgaatgg taatcgagct tggcgctacg tctactactg
     1981 ttgcacggaa aggttgaata atcgctaaaa tctcagctct cttctcagct ggcgctgaca
     2041 tcttaaccaa aatcacctcg cgctccaaat gaggcttgtc tgtaatatct cgaatgcgaa
     2101 tcacatcaat ctgacgattg agctgtttga tgatttgctc cacttcatca tgagaagcaa
     2161 catcaataat aatagtgata cgcgatacat tcggatcttc tgttgctcca acagagatgc
     2221 tttcaatatt aacctgacga cgagatagga cacctgtaaa gcgattgagg actcctgaac
     2281 gattttgtag ttttgctgtt aacattctac gcatggaact gcacccccaa catctcatga
     2341 ttactcttac cagccggtac cattggtaac acctgttcct tacgagaaat atctacctca
     2401 attagcatag gaacatcctc agtgatgact tcaaggtctt gagccaaggt ctcaggattg
     2461 tcaaacttat agtttttaat accataagcc tgcgccatca attggaaatc aggaagggta
     2521 tcaaagaccg actctgatgt tctgccttca tagaaggatt cctgccactg gcgaaccatt
     2581 ccaagtgaat gattgttcag cataaccacc ttgattggca ccttgtaaat attcaaaata
     2641 gccaactcct ggttggtcat ttggaaacca ccatccccaa caaacaagac tacttcctta
     2701 tctgggttag caattttagc accgattgct gctggaattc caaagcccat tgttcccaaa
     2761 ccacctgaag tcactaactg acgttcattt tggtagggat aatactgagc tgtccacatt
     2821 tggtgttgac caacgtctgt taccacaatg gcatctccat tcgtcaattc accaattcgt
     2881 tcaataactg cttgcggttg aaccacacgc tctttcttat cataagaacg aacacgattc
     2941 ttgtctttag tgactttctc aatccacttt tcagtgttgt tgtgaactgt tggttctgct
     3001 agcaacattt gcaaggcctt cttagcatct ccaactacag gaatgtctgc actgataatc
     3061 ttgccaatct cagctgggtc aatatcaatg tgggcaacct tagcattctt agcgaaagtc
     3121 ttaggattcc ccgtcaaacg gtcatcgaaa cgagaaccaa tactaatcat aaagtccgct
     3181 tccgtcatag caatatttgc tgcgaatgac ccgtgcatgc ctcccattcc aagaaagagt
     3241 gggtgactcg ttgcaatcgt tccttgtccc aaaagactgg ttaccactgg aatttgatag
     3301 cgttctgcaa attcatttag ttccgtagca gcctcagcat aactaattcc accaccagct
     3361 aacaagactg gctttttagc cttggacaat tgcttcaaga ttttcttgat ttgcatatca
     3421 ttcggctcaa gagtcggctg ataacttggt aaattcactt ctggtgaata aatgaagtct
     3481 gtttctaaag cagatatgtc ttttggtagg tcaattacaa ctggccctgg acggcctgta
     3541 gttgcgatat ggacagcttc cgtaatgata cgcggaatat cagctgtctc acgaacttgg
     3601 taattgtact tagtgattgg catggtaatt cccacgatgt ctgcctcctg aaaggcatcc
     3661 ttcccaatcc ctgctcgcgc cacctgacct gtaaagacca aaaggggaac gctatcgctc
     3721 atggcatccg caatccctgt aatggcattt gttgctcctg gtccactagt gacgacggca
     3781 acacccaact ttccagttga tttggcataa ccttcagctt catgcaaaca accttgctca
     3841 tggcgcccta gaatgtggcg aatgccttta aaattatata tcgcatcata aaaaggcaaa
     3901 accgcaccac caggataacc aaagatggta tcaactccta aatcacgaag tgtttccaaa
     3961 actaggtccg accccgtctt aggagattct aaactgattt tctccattat tcccctttct
     4021 ttcctcttaa aaataacttg ttactatcat accatttttt caaaattttt caagataaaa
     4081 gaagaaattt tctgaatttt ctattttaac gtttatttat gaatgttatt tttgttttta
     4141 ttaaaaagat accgatttca tttactaaaa agaaaaaaga actgatttct cagtccttca
     4201 ttaatcttat tccacactaa ataggtatgg gtaaacaggt tgttgacctt ggtgaatctc
     4261 gacttcaacg tcttcgaatt cttctacgat ttcttgagcg atttcattgg caagttcttc
     4321 gcttccgtct tcacctacat agaaggttac gatttcactg tcttcatcca acatatgttt
     4381 caaggtttca gtcaatgttt ggtgcatatc agggtttgac acaagaattt ttccatccac
     4441 catacctaaa ttatcgtttt catggatttc taagccatcg atcgttgtat cacgcacggc
     4501 tgttgtgacg cttccgctaa cgacatcgct aagagcagct gtcatacgct cttggttttc
     4561 ttcaatggac ttgcttggat caaaggcaag aagacttgtc ataccttgag gaagagtgcg
     4621 agcctctacc actaccgctg gttgctccaa aacttctgcc gcagattgag ctgccatgaa
     4681 gatgttcttg ttgtttggca agaagatgat gttacgggca ttaacctgtt caacagcctt
     4741 gataaagtct tctgttgaag ggttcatggt ttgaccgcct tcgataacat aatccacgcc
     4801 ttgagaacag aagatatctg ctagaccttt accagccacc acagcaatca aagcatactc
     4861 tttttcttca gccgacttga taacttgagt agcttctttc tcaacctgtg cttcgtgttg
     4921 gttacgcata ttgtcaactt ttaccttgac caagctacca tatttgagac cttcttgcat
     4981 aacaagtcct ggatcttctg tatgaacatg gactttgaca atttcatcat cgttaacaac
     5041 gaggagagaa tctccaagct catccaagta gttacggaat tcatcgtagt caaaatcttt
     5101 agcataggtt ggaccttgct taagagctac catgatttca gtacagtaac caaacgtgat
     5161 gtcctcagtc gctacgtgac cagctacaga cttatgatgc tctacattga tcatctcact
     5221 catgttggca ggagtcgcta caaagtcctc agatgcaata tattcgccag taagggctga
     5281 aaggaaacct tcgtagatga agaccaatcc ttgaccacct gagtccacaa cgccaacttc
     5341 tttcaatact ggaagcatgt ctggtgtttt agctagagct gttttagcac cttccaaggc
     5401 tgcgcgcatg acttcaacag cgtcatctgt ttgctcagct tttttcttag caccgatagc
     5461 agctccacga gaaactgtta aaatcgttcc ttcaacaggt ttcatcactg ccttataggc
     5521 aacttccaca cctgattgga aggccagagc caagtcttga cctgttaact cgtctttatc
     5581 cttgatagct tgggaaaatc cacggaaaag ctgagacgta atcactcctg agttcccacg
     5641 cgcacccatc aaaagccctt tggcaagaat gctcgctact tctccaactg tagaagctgg
     5701 cttgtctgca acttctttag caccattttc aatggtcatt cccatatttg tcccagtatc
     5761 tccatctgga actggaaaga cgtttaatga attgacatat tcagcttgct tattcaagcg
     5821 agttgatgca gcctgcacca tttcttgaaa taagctagta gtaatttttg acacgattat
     5881 tctcctacaa ctttgatatt ttgaatgtag acatttacag tctgagcagt aattccaagc
     5941 tggttttcca agctaaaggc aacacgctct tgaatgtttt ttgacacttc actaatcttt
     6001 gttccgtagc ttaacacggt atatacatca actgcaatac tgccatcttc ggctgccttt
     6061 acgacgacac ctttagaata attttcctta cctagcaggg cttggaaatt atctttgagg
     6121 gcatttttac tagccatacc gaccacacca aaaatctcag ttgctgctcc acctacgacg
     6181 gttgcaatca cttcatctgt tagttcgatt tgaccatctt ttgtattaat ttttacagtc
     6241 atccttttta cctcaactag ttgatactct attttatcat atttcagccc aagtgtaaaa
     6301 gcagaatgat gtatcagcgg atatttactc tatttttcaa acgatgttat acccacaata
     6361 aaagaaaaaa gaccctaagg tctcctttgc ttttattatt aaacgcgttc aactttacct
     6421 gatttcaaag cacgagctga agcccaaact tttttaggtt taccatcgat aagaacagta
     6481 actttttgaa ggtttggttt tacggcacgt tttgtttggt tcatcgcgtg tgaacggttg
     6541 tttcctgata cagtcttacg acctgtaaag taacatactt tagccattgt gttttcctcc
     6601 tattagatct aatatagcgg atgtgctagc accacatacc gtactatgtt atcacacttt
     6661 cttgtttttt gcaagggaat tggaagattt tttatttgtg tcttaaatca ggtcttgcgt
     6721 gacattttct gctctccaca tgccattgtt gattaacaga acaccagaat taaaattatg
     6781 tgtataaaaa tcatctctaa ctgcagctaa gggtatagcc gtcaagtcca aatcccacag
     6841 ctcatctatc gattttctta caacaatatc taaatccaaa tacagtacac gagactcgct
     6901 tacatacttt ggaataaaat atctaaaaaa gccgcatatg aaagtccctc aaaggggaga
     6961 cgataacctt tcagaatact actgtcaatc taaacattca caatctcact attcaaagtc
     7021 tctagtcttt tttccatcaa ttggaaccat tctcgcggaa ggtcatcatt aaaaacataa
     7081 aacttaagat tataatagat gaacacaaag agattttatt gttgtttcaa ctttatccat
     7141 ataagcatta tctgcaccta agacaatcgc ttttttctct tctttcactt tttatctcat
     7201 ttctttttat tcccatcata tgtttctacg taaccattat tttcgcctat tcgttcgtaa
     7261 aaccatacca gtggagattt tagatgaagt cccattacgg tttacaattt ttacattacg
     7321 acacggagtt ttacaaatcg atttcatttg ccaaacgtag ttagtaaggc agttagctag
     7381 gctacctact ttctgctacg acggaaaaat ccacaaatca ataccattcg tggatttttc
     7441 ctagtgaagc gtttaggtaa gccgccatag cggttaccga ttattagatt acgacacgga
     7501 gtttggcaaa tcgattctat ttgccaaacg tagttagtga ggcagttagc tagttcgcca
     7561 aatagcgact agcgtccaac aattggaact ttagttccaa ttgttggtac tgagtcacat
     7621 cttctcctct aactctacgt ctggatactt gtccgcaaac cagcggaggg caaagtcatt
     7681 ttcaaagaga aagactggtt ggtcaaaacg gtctttggct aagatattgc gacttgacga
     7741 catccgttca tccaagtcct caggcttgat ccaacgaacg gtctttttac ccattgggct
     7801 catgaccact tccgcattgt attcgccttc catacggtgt ttaaagactt caaactggag
     7861 ttgaccaaca gctcccagca tgtactcacc tgtttggtaa ttcttataaa gctgaacggc
     7921 tccttcttgc accaattgct caatcccctt gtggaaggat ttttgcttca taacattctt
     7981 agcagaaact ttcatgaaaa tttcaggagt aaaggttggc agtggttcaa attcaaactt
     8041 gttttttcca accgtcaagg tatccccaac ctgataagta ccggtatcgt aaaccccgat
     8101 aatatcacct gccacggcat tgatcacatt ctcacgactt tccgccataa actgggtaac
     8161 attagatagt ttagccccct taccagtacg agggagattg acactcatgc cgcgctcaaa
     8221 ttcgcctgat acgatacgga caaaggcaat acggtcacgg tgacgaggat ccatgttggc
     8281 ttggatttta aagacaaagc ctgagaaatc cttgtcataa ggatccacaa tttcaccgtc
     8341 tgttttcttg tgaccatgtg gttctggagc aaacttgagg aagatttcaa ggaaggtctg
     8401 cacaccaaag tttgtcaggg ctgaaccgaa aaagacaggc gtcaattctc cagccagaat
     8461 agcttcctct gaaaactcat tcccagcttc atttaaaagc tcaatgtcat ccttgacttg
     8521 ctcgtagaaa ggattgctac caaagagttt gtccccgtct tctagactgg caaaacgctc
     8581 atcccctttg taaagctcta aacgttggtt atagaggtca tacaagccct caaaggcttt
     8641 ccccatcccg ataggccagt tcatagggta gctagcaatg cccaagattt cttccaattc
     8701 ttgcaagaga tccaaaggct cacgaccgtc acggtccagc ttgttcataa aggtaaaaac
     8761 tggaatgcca cgatgtttca caacctcaaa caatttcttg gtttgagcct cgatcccctt
     8821 ggcagagtcc acgaccatga ccgcagcatc caccgccatc aaggtacgat aggtatcttc
     8881 tgagaagtcc tcgtgccctg gcgtgtctaa gatattcacg cgcttgccgt cgtagtcaaa
     8941 ttgcataaca gatgaagtaa cagaaatccc acgttgcttc tcgatatcca tccagtcaga
     9001 tttagcaaaa gtccctgttt tcttcccttt taccgtacca gcctcacgaa tctcaccccc
     9061 aaagtagagt aactgctcag tgatggttgt tttccccgcg tccgggtggg agataatggc
     9121 aaaggtacga cgtttcttaa tttcttcttg aatattcata agttctcttt ctttgattct
     9181 ctatttttct tgtttcaata gctgagaatg atttttacat tggattttac cattcctttc
     9241 aacactccat tatatcggat tttagcattt ttttcaattt ctatttcttt tcacttcccc
     9301 ctcccttatt tataggaaaa tatggtaaaa tagaacagac taaaaatcat catttcacga
     9361 aaggatgcaa gatgaaaatt acgcaagaag aggtaacaca cgttgccaat ctttcaaaat
     9421 taagattctc tgaagaagaa actgctgcct ttgcgaccac cttgtctaag attgttgaca
     9481 tggttgaatt gctgggcgaa gttgacacaa ctggtgtcgc acctactacg actatggctg
     9541 accgcaagac tgtactccgc cctgatgtgg ccgaagaagg aatagaccgt gatcgcttgt
     9601 ttaaaaacgt acctgaaaaa gacaactact atatcaaggt gccagctatc ctagacaatg
     9661 gaggagatgc ctaatgactt ttaacaataa aactattgaa gagttgcaca atctccttgt
     9721 ctctaaggaa atttctgcaa cagaattgac ccaagcaaca cttgaaaata tcaagtctcg
     9781 tgaggaagcc ctcaattcat ttgtcaccat cgctgaggag caagctcttg ttcaagctaa
     9841 agccattgat gaagctggaa ttgatgctga caatgtcctt tcaggaattc cacttgctgt
     9901 taaggataac atctctacag acggtattct cacaactgct gcctcaaaaa tgctctacaa
     9961 ctatgagcca atctttgatg cgacagctgt tgccaatgca aaaaccaagg gcatgattgt
    10021 cgttggaaag accaacatgg acgaatttgc tatgggtggt tcaggtgaaa cttcacacta
    10081 cggagcaact aaaaacgctt gggaccacag caaggttcct ggtgggtcat caagtggttc
    10141 tgccgcagct gtagcctcag gacaagttcg cttgtcactt ggttctgata ctggtggttc
    10201 catccgccaa cctgctgcct tcaacggaat cgttggtctc aaaccaacct acggaacagt
    10261 ttcacgtttc ggtctcattg cctttggtag ctcattagac cagattggac cttttgctcc
    10321 tactgttaag gaaaatgccc tcttgctcaa cgctattgcc agcgaagatg ctaaagactc
    10381 tacttctgct cctgtccgca tcgccgactt tacttcaaaa atcggccaag acatcaaggg
    10441 tatgaaaatc gctttgccta aggaatacct cggtgaagga attaacccag aggttaagga
    10501 aaccattcta aatgccgcta aacactttga aaaattgggt gctattgtcg aagaagtcag
    10561 ccttcctcac tctaaatacg gagttgccgt atactacatc atcgcttcat cagaagcttc
    10621 atcaaacttg caacgctttg acggtatccg ttacggctat cgcgcagaag atgcaaccaa
    10681 ccttgatgaa atctatgtaa acagccgaag ccaaggtttt ggtgaagaag tgaagcgccg
    10741 tatcatgctg ggtactttca gtctttcatc aggttactac gatgcctact ataagaaggc
    10801 tggacaggtc cgtacactta tcattcaaga tttcgaaaaa gtcttcgcgg attacgattt
    10861 gattttgggt ccaactgctc caagtgttgc ctatgacttg gattctctca accatgaccc
    10921 agttgccatg tacttagccg acctattgac catacctgta aacttggcag gactgcctgg
    10981 aatttcgatt cctgctggat tctctcaagg tctacctgtc ggtctgcaat tgattggtcc
    11041 caagcactct gaggaaacca tttaccaagt tgctgctgcc tttgaagcaa caacaggcta
    11101 ccacaaacaa caacccgtga tttttggagg tgacaactaa tgaactttga aacagtcatc
    11161 ggacttgaag tccacgtaga gctcaacacc aattcaaaaa tcttctcacc tacttctgcc
    11221 cacttcggaa atgatcaaaa tgccaacact aacgtgattg actggtcttt cccaggagtt
    11281 ctgccagttc tcaataaagg ggttgtcgat gccggaatca aggctgctct tgccctcaac
    11341 atggacatcc acaaaaagat gcactttgac cgcaagaact acttctaccc tgataatccc
    11401 aaagcctacc aaatttctca gtttgatgag ccaatcggtt ataacggctg gattgaagtc
    11461 gaactagaag acggtacgac caagaaaatc ggtatcgaac gtgcccacct agaggaagac
    11521 gctggtaaaa acacccatgg tacagatggc tactcttatg ttgacctcaa ccgccaaggg
    11581 gttcccttga ttgagattgt atctgaggca gatatgcgtt ctcctgaaga agcctatgct
    11641 tatctgacag ccctcaagga agttatccag tacgctggca tttctgacgt taagatggag
    11701 gaaggttcga tgcgtgtgga tgccaacatc tcccttcgtc cttatggtca agagaaattc
    11761 ggtaccaaga ctgaattgaa gaacctcaac tccttctcaa acgttcgtaa aggtcttgaa
    11821 tacgaagtcc aacgccaggc tgaaattctt cgctcaggtg gtcaaatccg ccaagaaaca
    11881 cgccgttacg atgaagcgaa taaagcaacc atcctcatgc gtgtcaagga aggggctgct
    11941 gactaccgct acttcccaga accagaccta cccctctttg aaatttctga cgagtggatt
    12001 gaggaaatgc ggactgagtt gccagagttt ccaaaagaac gtcgtgcgcg ttatgtatct
    12061 gaccttggtt tatcagacta cgatgctagt cagttgactg ctaataaagt cacttctgac
    12121 ttctttgaaa aagctgttgc cctaggtggt gatgccaaac aagtctctaa ctggctccaa
    12181 ggggaagtcg ctcagttctt gaatgctgaa ggtaaaacac tggaacaaat cgaattgaca
    12241 ccagaaaact tggttgaaat gattgccatc atcgaagacg gtactatttc atctaagatt
    12301 gccaagaaag tctttgtcca tctagctaaa aatggcggtg gcgcgcgtga atacgtggaa
    12361 aaagcaggta tggttcaaat ttcagatcca gctgttttga ttccaattat ccaccaagtc
    12421 tttgcggata acgaagctgc tgttgccgac ttcaagtcag gcaaacgtaa tgcagacaag
    12481 gccttcacag gattccttat gaaggcaacc aaaggccaag ccaacccaca agttgccctt
    12541 aaactacttg cacaggaatt ggcgaagttg aaagaaaact agacagaaca aaaccagccc
    12601 taaggttggt tttttcttga caaatagaaa gaaaacgttt gcaatattgc gtgtaaagtt
    12661 tccaaacaag aaaactaaaa atcgcaacaa taaggagtta tttatatggc tacaatgaag
    12721 gcagctcgct ggcatgcagc gaaagatgtt cgtattcaag aaatagaagt tcctgaagta
    12781 cttccgcacc aagtaaaagt tgcagttaag ttcacaggaa tttgtggtac tgacctccat
    12841 gaatttttag atggacctat ctttatccca acagatgagc acgtctattc tggtcaaaaa
    12901 gcaccggtaa cactgggaca tgaattttct ggtgaaatca tagaagtcgg aagcgatgtt
    12961 acccgtgtta aagttggtga tcgtgttgct gtggaaccaa ttctagctaa aaataactta
    13021 gttggtgatt ataatttgga tccaaacctt aattttgtcg gtttggctgc agacggtgga
    13081 tttgccaaat attgtgtttt agacggtgac ttagtacatg tcattccaga tagtttgagc
    13141 tatgagcaag ctgctcttac tgaacccgct gctgttgcag tctatgctgt tcgtcaatct
    13201 tctttgaagg ctggcgatac agctgttgtc tttggtttag gcccgattgg tctattaatt
    13261 gtagaagctc ttcgtgcagc tggtgcttct aagatttatg ctgttgaact atcacctgaa
    13321 cgtcaagcaa aagctgaaga gttaggagct atcgttgtcc gtccggaaga aggtgaaaca
    13381 gctgttgaag ctattcatcg tttaacaaac ggtggtgtag atgtttctta tgaagtaacg
    13441 ggtgtgccag tagttttagg acaagcctta gctgccgtac ataaagcagg tgagtgcatg
    13501 gtggtctcta tctgggaacg agaagcaaat attaatccga atgaatttgc aatccaagaa
    13561 aagacactaa aaggaatcat tgcttatcgt catatcttcc ctaaagtatt agaattgatg
    13621 gaacaaggct acttctctgc tgaaaaatta gttactaaga aaattaaatt ggaaaatatc
    13681 gtcgaagaag actttatcga attaactcaa gataagtcac aaattaaaat tttggtagaa
    13741 ccagaataaa aaatcaatct ttttaagaca atactaacag gtcggagtaa acttacttcg
    13801 gccttttgaa atataatact cttcgaaaat ctcttcagac cacgtcagcg tcacattacc
    13861 gtatatatgg ttactgactt cgtcagttct atccacaacc tcaaaacagt gttttgagca
    13921 gcctgcggct agcttcctag tttgctcttt gatttccatt gagtatgaga agaaatatag
    13981 tggatactct ttaacattaa ccactccacc tgactagcca atattctttt tcgctcctac
    14041 caactcccaa taactatttt ggctttattt ccagagtatt ttatggtaaa atgaagagta
    14101 ataatattta ttaaagaggt aaaaacatga ttgaagcaag taaattaaaa gctggtatga
    14161 cctttgaaac agctgacggc aaattgattc gcgttttgga agctagtcac cacaaaccag
    14221 gtaaaggaaa cacgatcatg cgtatgaaat tgcgtgatgt ccgtactggt tctacatttg
    14281 acacaagcta ccgtccagag gaaaaatttg aacaagctat tatcgagact gtcccagctc
    14341 aatacttgta caaaatggat gacacagcat acttcatgaa tacagaaact tatgaccaat
    14401 acgaaatccc tgtagtcaat gttgaaaacg aattgcttta catccttgaa aactctgatg
    14461 tgaaaatcca attctacgga actgaagtga tcggtgtcac cgttcctact actgttgagt
    14521 tgacagttgc tgaaactcaa ccatctatca aaggtgctac tgttacaggt tctggtaaac
    14581 cagcaacgat ggaaactgga cttgtcgtaa acgttccaga cttcatcgaa gcaggacaaa
    14641 aactcgttat caacactgca gaaggaactt acgtttctcg tgcctaatct ctagaaagag
    14701 gtcattctat gggaattgaa gaacaacttg gcgaaatcgt tatcgcccca cgtgtacttg
    14761 aaaaaatcat tgctatcgct actgcaaagg tagagggtgt tcactctttt tcaaacagat
    14821 cagtgtctga taccctttca aaactttcac tcggccgtgg catttatctt aaaaacgtgg
    14881 acgaagaact cacagcagat atctatctct accttgagta cggagtaaaa gttcctaagg
    14941 tagcggttgc tatccagaaa gctgtcaaag atgccgtccg taatatggct gatgtagaac
    15001 tcgctgctat caatattcac gttgcaggta tcgtcccaga taaaacacca aaaccagaat
    15061 tgaaagatct atttgacgag gacttcctca atgactagtc cactattaga atctagacgc
    15121 caactccgta aatgcgcttt tcaagctctc atgagccttg agttcggtac ggatgtcgaa
    15181 actgcttgtc gtttcgccta tactcatgat cgtgaagata cggatgtaca acttccagcc
    15241 tttttgatag acctcgtttc tggtgttcaa gctaaaaagg aagaactaga taagcaaatc
    15301 actcagcatt taaaagcagg ttggaccatt gaacgcttaa cgctcgtgga gagaaacctc
    15361 cttcgcttgg gagtctttga aatcacttca tttgacactc ctcagctggt tgctgttaat
    15421 gaagctatcg agcttgcaaa ggacttctcc gatcaaaaat ctgcccgttt tatcaatgga
    15481 ctgctcagcc agtttgtaac agaagaacaa taaaaagaaa aagtgtttga tagatatcaa
    15541 acactttttt ctttgcctcc cactatctaa aaaaatgata atagatataa ttgtaaacaa
    15601 aaatccagat aggttttgca tgattgagaa agttaaaaaa actatggcag agaatcgtta
    15661 atctcagatt gtcggtagaa cgataaacaa gggcaaaaaa gaaaccaatc agactataat
    15721 ataataaact aattggatct ctgtgagata gtatcaaatg gctaatccca aagatgatag
    15781 cagataggat aacatccaaa taatacttgg actagggaaa gaaggtgttc ataaaatacc
    15841 ctctatcaag agtctcctca aaaacaggac cgatgattac aggcaggaca aaagataaga
    15901 tagtcgataa aaaggttggt tgtccatttg aaagaaccac ggtaaaatac tcatcatgaa
    15961 tattcctatg attaatcaaa tgagcatagc gtgcccaaaa attaccgaga atctgataaa
    16021 ccacataagt tgcaaataag gagaagacaa atgaccagtc ccagctcttt ttctttttta
    16081 acctccaaat taatagaaaa ggaaacttcc cactaatccc actgttaaaa taagagaata
    16141 gacatcagct cctaacccta aaatgatcgt cacatacaat ccaattgttt gtggtaaata
    16201 ggtagatagt aaaataataa gcaaaaatat tccaaattgt cttagtttct ttgtgtttct
    16261 catcgtactt ttttgaaaga ttaccctgtt cggaagccgt acttccaagc atctatataa
    16321 gaattaagtg ccccttgcct catataggga gcaaattctc tataatataa ccatctacta
    16381 tatccatctt cccaaacagc aagaccactt gaagtttgct ccaagtcctc agttgaaata
    16441 actgtaaatg tttctgtacc tgtcattgca agtaccttct taaaatatag tgatttgaaa
    16501 taagatgtga acaactctat caggaaagtc aaattaattt atagaaatat tttagcagcc
    16561 aaggtgtact gttatagatt caatacacta taaatttttg taagcttaca tctacagtat
    16621 acatcttttt tgtctatttt atagcccatc tcctcaactg tcaatttttc aacctgaatt
    16681 gcatttttcc ataaaaaatg agacctttct agtctcattt agtcattctt agtattttct
    16741 aaatcgttga tagcgttctt ccagcaactc ttctagcggt ttttgtgaaa gtctagccag
    16801 ctccgtttgg agttcttttt tgacactctt aatcagttct ttactagaaa gtcctacttc
    16861 agaaatcacc ttatccacca cgtccatttc taacagttca tgcgaagtga ttttcatcag
    16921 ttctgctgct tccatggcgc gagtaccgtc cttccataaa atggaagcaa agccttctgg
    16981 actgagaatg gcatagatag aattttccag catccagaca cggtccgcga cagctagagc
    17041 cagagccccg cctgaaccac cttcaccgat aataatggcg ataataggaa ctttcaggtc
    17101 actcatttcc atgagattgc gagcgatagc ttccccttga ccacgttctt ccgctccgac
    17161 accaggataa gcacctgctg tattgataaa ggtcacaact ggacggccaa atttctcagc
    17221 ctgtttcatc aaccgcagtg cctttcggta gccttctgga tgtggttggc caaaattccg
    17281 tttgaggttg tcttgcaaac tcttgccttt ttggatacca accactgtta cagcttggtc
    17341 tccaagccaa ccaataccac caacaactgc accatcatca cgaaaagaac ggtcaccatg
    17401 taattggata aattcatcaa aaatgcctgt agcaaagtcc aaggttgtca agcgactctg
    17461 ctcacgcgct tctctgacta tttttgcaat attcatctag gactccctcc atgcaatctg
    17521 actaggctag caatcgtatc tggtaagtct cttcttttga caatagcatc cacaaagcca
    17581 tgttctaata ggaattctgc cttttggaaa tcctcaggca agctttcacg aaccgtattt
    17641 tcaatcacac gacgtccagc aaaaccaacc aagctctgtg gttcagccag aatgatatcg
    17701 ccttccatag cgaaagaagc tgtcacacca ccagtcgttg gatctgtcaa aatggtcagg
    17761 taaaagagac cagcatttga atggcgttta accgccgcag agatcttagc catctgcatg
    17821 agactcatga ttccttcctg catacgggct ccaccagagg ctgtgaatag gacaactggc
    17881 aatttttcga cagtcgcata ctcaaacaaa cgagtgattt tttcacctac aaccgtaccc
    17941 atagaagcca tgataaagtt agaatccata atcccaagag ccacagtctg acctttaata
    18001 agagcagttc ctgtcacaac ggcttcatgc agacctgttt tttcacgcat agatgccagt
    18061 ttcttttggt aaccagggaa atgcaaggga tccttgcttt caatccctgt aaacaattct
    18121 ttgaaggttc ccatatcaat cgtcaaagcc aagcgttctt gggcagaaat acgaaaggta
    18181 tagctacagt gcggacagat acgttcactt cccagatcct tctgatagat ggtatgctta
    18241 cagcctggac actgggaaaa taattcatct ggaacctctg gcttagcttg aggtttttcc
    18301 ctaaccgaac gattgggatt gattcgaata tacttatctt ttttactaaa tagagccatt
    18361 gattcccctt ttcggtttaa actcttaaag tcattttatt ctttttcttg atatttaggt
    18421 aagaaggttt ccatcaagaa ggaagtatca taatccccag caatgacatt gcgatctgaa
    18481 atgaggtcaa gctggaaatc tgcattggtc tgcactcctt caatctctaa ttcatagagg
    18541 gcacgttgca ttttcatcaa ggcgtcaaaa cgattttcgc cgtgtactat gattttggca
    18601 atcatactat cataataagg cggaatggta taacctggat aaactgctga atccacgcgc
    18661 aagccaactc caccacttgg cagatagaga ttagtaatct tacctggact tggagcaaag
    18721 ttaaaggctg ggttttctgc attgatacga cactcgatgg catgaccgcg taggacaata
    18781 tcttcttgct taacagacaa aggctgacct gccgcaatgc aaatctgttc cttaacgata
    18841 tcaacacctg aaacaaactc tgttactgga tgttctacct gaacacgagt attcatctcc
    18901 atgaaataga aattgctact tgcttcatca agaagaaatt caatggttcc tgcattctca
    18961 tagccaacaa actctgccgc tcgaacagca gcagcaccta tttcatgacg cagcgttttt
    19021 ccgattgcaa tcgagggact ttcttccaaa accttttggt tattcctttg aagagaacaa
    19081 tcccgctcac ccaagtgaat cacatgtcca tgctcatcac ctaggatttg aacctcaatg
    19141 tgccgagctg gatagataac ccgttctatg tacatggcac cattgccata attggccttg
    19201 gcctcactag aggcagtttc aaaggcagaa acgaggtcat ctggtttttc aaccttacga
    19261 atccctttac cacctccacc tgctgaagcc ttgagcataa caggatagcc aattttttca
    19321 gcaacaatca aagcttcttc agagttatgc acttctccat ctgaacctgg tataacaggc
    19381 acacctgctt taatcatctg agcacgcgca ttgatcttat cccccatcat atccataaca
    19441 tgaccagatg gaccgataaa cttgatacct acttcttcac acatggtcgc aaatttggaa
    19501 ttttcactga gaaatccaaa accagggtga atagcttctg cctcagtcaa gactgcagct
    19561 gatagaactg cattaatatt gagataagac tctgttgcct tgccaggacc aatacaaact
    19621 gcttcatctg ccaaaagcgt atgaagagct tccttatcag cagttgaata aaccgctacc
    19681 gtcgcaatcc ccaattcacg tgccgcacgg ataatacgaa ccgcaatttc accacgattg
    19741 gcaattaaaa tttttcgaaa catggagaac ctccttagtt cccaattgca aaagtaagga
    19801 taccactggc tgcaagcttg ccatccactt cagcctttgc ttcaaccaca gctatggtgc
    19861 cacgacgttt tacaaaagtc gctgtcataa ccaattggtc gcctggtaca acttgcttct
    19921 tgaacttaac cttgtccata ccagcgtaaa agaccagttt tcctttattt tcaggttttg
    19981 ataactccaa cacaccagca gtttgcgcca aggcttccat aatcagaaca cctggcataa
    20041 ctgggtattg aggaaagtgg ccgttaaaga aaggttcgtt aatggtcaca tttttgatag
    20101 caacaatggt atcctcgctc acttccaaga cacggtccac tagaagcata ggataacggt
    20161 ggggaagagc ttctttgatt ccttgaatat cgatcatttg atacgtacca atcctttacc
    20221 aaactcaacc atttcttcgt tagagacgag aatttccgtt accacaccat ccttaggagc
    20281 tgggatttca ttcatgactt tcatggcttc gataattacc aatgtttgac cttttttgac
    20341 actatcacca actgtaacga aggcaggttt atctggtcca gcagccaagt aaaccactcc
    20401 aacaagtgga ctctctacaa gatttccctc agtagccaca cttgcttcag ctggagctgg
    20461 aacttcttct gctacagtct ctgctggagc agatgtagga gctactggac tcggtgttgc
    20521 tagaacgggt gctggagcga cttgagttgc aacttcaggc acaggtcttg cttcattctt
    20581 gctaaactgc aactcatccg tcccattttt ataagaaaat tctctcaaac ttgactggtc
    20641 aaattgagtc atcaagtctt taatatcgtt taaattcata cttatctatt ctcccaacgt
    20701 ttgaaagcaa gaactgcatt gtggcctcca aaaccaaaag tatttgaaat agcgtatgga
    20761 atttctttct ccaaaccttg tccataaacg acattagctt cgatataatc tgatacttca
    20821 cttgtcccag ctgtcattgg tacaaagtta tgacgcatag cttcgatggt gacgatagct
    20881 tctactgcac ccgcagcccc cagcaaatgt cctgtaaaag acttggttga tgatacaggt
    20941 acttccttac caagaacagc tacgatagca ccactttctc ctttttcatt ggcaggagtt
    21001 gacgttccgt gagcattgac ataggctact tgctctggag aaatctcagc ttcttccaag
    21061 gctagtttga tggccttgat agctccctga ccttctggat gtggagaagt catgtggtag
    21121 gcatcacaag tatttccgta accaaccact tcagccagga tagtagctcc acgtttttca
    21181 gcgtgttcaa gactttctag aaccaacatc cctgaacctt cacccataac aaacccattg
    21241 cgatccttat caaatgggat cgaagcacga gttggatcct ctgtagtaga gagagctgtt
    21301 aaggcttgga aaccagcgat ggcaaaaggt gtgatagaag cttctgttcc tcccaccaac
    21361 atcacatctt ggaaaccaaa cttaatggag cggaaggcat ccccaatcgc atcatttgat
    21421 gaagagcagg cagtattgat agatttacaa acaccgtttg caccaaaacg catggctaca
    21481 ttcccagaag ccatatttgg taaagctttt ggaagagtca ttggtttgac acgtttgggt
    21541 cctttttcat gaaggcgaag tacctgatct tcaatttcct tgattccacc aataccagat
    21601 gcaacgataa caccaaaacg atccctatta agagcctcta catcaagatt ggcatgattt
    21661 acagcctctt gggctgcata caaggcatat aaagaatagt tatcaaaacg gttggtatct
    21721 ttttttacaa agtatttatc gaacggaaaa tcttggattt ctgccgcatt atgcacatca
    21781 aagtcactat gatcaaattt tgtaatgcca ccaatgccga ttttcccagt tgctaaacta
    21841 ttccaaaatt cttctggtgt atttccgatt ggagatgtta ctccataacc tgttaccact
    21901 actcgattta gtttcattct tttcacctct agctttcgct acatacttaa gccaccatca
    21961 atggcaatca cttgaccagt tagataatct tggcctgcta aaaatactgt caaatctgca
    22021 acctgctctg cctgcccaaa ttctttcatc ggaatctgag ctagtgtagc ttccttaatc
    22081 ttatctgata agatagctgt catatcagac tcaatcattc ctggagcaat cacattgact
    22141 cgtatattcc gactagcgac ctcgcgtgcc acagacttgg taaagccaat caagccagcc
    22201 ttagaagcag catagttagc ttgaccaata ttccccatca aaccaacaac actagacata
    22261 ttaatgatag caccttctct ggctttcatc atcggtttca agactgattg tgtcatatta
    22321 aaggcaccag tcagattgac cttgagcact ttttcaaaat ctgcttctgt catcttgagc
    22381 ataagagtat cttgggtaat ccctgcattg ttgaccaaaa catctactga acccagttct
    22441 gcaatagctt gatcaatcat acgcttagcg tctgcaaaat ctgatacatc tcctgaaatg
    22501 ggaaccacct tgataccata gtttgaaaac tcagagagca attcttctga gattgcccca
    22561 cgactgttta agacaatgtt ggctcctgct tgagcaaact tgtgggcgat ggcaagacca
    22621 attccacgac tcgaacctgt aataaagata tttttatgtt ctagtttcat ttttttcctt
    22681 tcaaaacttc tacttatttt agtctatttt tctaaaagtg ctactaaact cgcttgatct
    22741 tccacatgag ctaagtgagc agtttgatca atttttttaa caaaacctga caagactttc
    22801 cccggtccaa tctcgataaa gttgcttatg cctgcttctt gcatgacccc aatactttca
    22861 tagaaacgaa cgggttcctt gacctgacgc gtcaagagct gagcaatgtc ctctttttgc
    22921 atcacagcag cttctgtatt gccgactagg ggacaagtaa aatctgaaaa acttacctga
    22981 gctagagttt cagctagttt ctggctagct ggctcaagga gagcggtgtg aaagggacct
    23041 gacaccttaa gaggaatcaa gcgtttggca cctgcttctt gcaaaagttc aaccgctcga
    23101 tcaactgcaa ccacttctcc agcaatgacg atttgtgcag gtgtgttata gttggctgga
    23161 gtaaccactc caagttcaga agctttttga caggcttctt caatgacctc tactggcgta
    23221 ttgagaactg ctaccatctt gccagagtca gcaggagtcg cttcttccat ataggctcca
    23281 cgcttagcta ccaaggcaac cgcatcttca aaatccaagg cgccgcttgc caccaaggca
    23341 gagtattctc caagagacaa accagcaacc atatcaggct gatagccctt ttcttgcaat
    23401 aaacggtaga tagcaaccga agtcgctaga atggctggtt gcgtatagcg ggtctgattg
    23461 agtttgtcct cttccgtatc gatgagataa cgcaaatcat aaccgagcac ctgactcgct
    23521 cgatcaatcg tttctttaac aatcggatac tgatcataga aatcccgtcc catccctaga
    23581 tactgggcac cttgaccagc aaataaaaag gctgttttag tcatttctta caactcctgt
    23641 ccagcgagag gcttcttctt gaattttctt agcggctccg taatacaaat cttttaggat
    23701 ttcttcagct gtttcttctt tagaaacaag ccctgcgatt tgacctgcca tgacagagcc
    23761 accatccaca tcaccgtgaa caactgcttt ggctagggca cctgctccca tttgttcaaa
    23821 gatttctaaa tcaggatctt cctgcttaaa ggcatctttt tcagccagtt caaaatctct
    23881 agtcaactga tttttaatag cacgaacagc atgaccaaag tgctgagctg aaatcgtagt
    23941 gtcaatatcc cttgctttta aaattttctc cttgtagttt ggatgggcat tcgactcttt
    24001 tgcaactaca aaccgtgtcc ccacctgtac agcctctgca cctagcataa agccagccgc
    24061 agcaccttca ccatccgcaa ttcctcctgc agcaataaca ggaatagata tagctgtggc
    24121 tacctgtcgc accaaggtca tggttgttaa tttaccgata tgccccccag cttccattcc
    24181 ttctgcaata acagcgtctg caccgatttt ttccatgcgt ttagctaaag cgacactagg
    24241 aacaacagga ataacgatta tcccagcttc atggaaacgt tccatatact tgcttggatt
    24301 tcctgctcct gttgtgacaa ctttaacacc ttcttcaata acgagatcca cgatatcttc
    24361 cacaaaggga gataagagca tgatgttgac cccaaagggt ttatcagtca atgatttgat
    24421 tttatcaata ttggccttga caacttcttt cggggcattt cccccaccga taattcctaa
    24481 tcctccagcc ttggaaacag cccctgccaa atcaccatca gcaacccagg ccatccctcc
    24541 ttggaaaata ggatagtcaa tcttcaataa ttctgtaata cgcgttttca tagtgcctcc
    24601 aaccttcctt gcttacgtaa tagttcgatt tcaccataat ttgacagtca aactattacc
    24661 taaacaagag ggagtgggtt tctccctact ccttctacta atattctgct tattttgctt
    24721 gctcttcaac gtaagcaacc aagtcaccaa ctgttttcaa gtcattttct gcttcgattt
    24781 ggatatcaaa agcatcttcg atttctgaga ttacttggaa caagtccaat gaatctgcgt
    24841 ccaaatcatc aaaagttgat tcaagtgtta cttctgatgc gtcttttcca agttcttcaa
    24901 cgataatttc ttgtactttt tcaaatactg ccatgatagg actcctttaa aataaatagt
    24961 ttttttataa caatgtgttc accacatgat tacctaaatt gtaagaatga gcgtgcccca
    25021 ggtcaagcct ccaccaaagc ctgatagaag aacagtctgg ctaccatcta aagggatgag
    25081 accttgttct acacactctg aaagtaaaat cgggatactg gctgcactgg tattgccata
    25141 ttccatcata ttggctggaa gtttggctcg gtcaacacca atttttctag ccatcttatc
    25201 caaaatacgg tcattggctt gatgaagtag cagataatcc aagtctgtca cctctatagg
    25261 agattcatca atagtctgct tgatagactt ggctacatct cgaatggcaa aatcaaagac
    25321 tgtgcgtcca tccatcttca aaaacgaatc tgcactttct tgatctgaaa atggagaatg
    25381 caaacctgaa tgcccataag ttaaacactc gctgcgactt ccatcgctat tgagactctc
    25441 agctaagaaa tgctcttgct cgctagcttc taacaagaca ccaccagcac catctccaaa
    25501 caacacagct gttgatcgat ccgaccaatc gactgcctta gagagggttt cactaccaat
    25561 caccaagcct ttttgaaagc gaccagaagc gataaacttt tcagcagttg aaagagcaaa
    25621 tacaaatcca ctgcaagccg cggttaagtc aaaagcaaag gctttattag cgccaatatt
    25681 agcttgaaca cgagcagctg tagagggcat catcgaatct ggagtaatgg tagctaggat
    25741 gataaaatcc agttcttctc ctgttattcc agcttttgcc atcagtttct tagcaacctc
    25801 tgtagccaaa tcactggtag attctgttct tgaaatatgc ctttgtcgta ttcccgttcg
    25861 acttgaaatc cactcatcat tggtatccat aatctgagcc aagtcgtgat ttgtaaccac
    25921 ttgctctggc acataatgag caacctgact tatttttgca aaagccatta tttcaaatcc
    25981 tccaaaaatt ggtaaagatt agtcaagcct ttacccatga cagcaatttc ttcctcgctc
    26041 atgccatcaa taattttttc taccatggcc ttgtggaagc gtttatgcag tctatgaatc
    26101 aagtgaccct tctttgtcaa atgcagatgc accacacgac gatcctgttc tgaccgaact
    26161 cgctcaatgt agcccttacg ctctaaattg ttcaaacttg tcgtaacagt tccaagagtt
    26221 accatcaact cttttgacac ttgacttgga gtcacatctg gagccttacc gatgacatca
    26281 atcgtatgca tttctttgat ggagatatcc ttaaaacgac tacctctcaa gttcacttcc
    26341 tcaattacaa ggacattgtt aaatatagat gttaaatatt cattgattcg ttggtagtcc
    26401 atttttcata tccctccttc ttcaaaaaac ttttacaatc aaaacatttg acagaaagaa
    26461 ttatatcaaa attcaaagaa tgatgcaagt attttttatt ttcctgtaaa tttaggtctt
    26521 cttctctccg aatgagctcg cactccttct ttgaaatcct ctgtttgagc taaggatttc
    26581 tgtaggttca gttctaaagt agcgtaaccc tgccagtctt taaattggct ctcccaaacc
    26641 aacttcttaa tggcagcata ggaattactt gaagcacgtc ttaatttttt aagaagctgt
    26701 tctctcgtct tttcaagttt ttcagcttca gaaacgcggt aaaccaaccc ccattctagg
    26761 gctttttctg ccgttaaagc ctctcctgtc atagctaatt gagcagcacg cgtcacaccg
    26821 atactgcggc tcaagagatg aattccccct gcatctggag ccaaaccaac accaacaaag
    26881 gcttggataa acttagcctt atccgtcgcc aaacagaaat ctgccgcaac agccatattc
    26941 gctgcggcac ctgcaacagc accgtcaact tccattaaaa caggtttggc tatttgcttg
    27001 attttataag aaatcgtatt gaccaactct gcgatttttg tcaatgatgg aatatcatcc
    27061 tcatccactg cccgcttcat ctctaccaaa tctcccccaa ctgagaagac ctttccattg
    27121 gcattgatta agataaaatg cacagctgga ttttcttctg ccaaagtcag agcttctaaa
    27181 atctcctcac acatgggaat atgaaaacca tttgcgacct caggacggtt caaggtaagg
    27241 attgccaagt cctcttcaag ctgataaata atgtgttcca tcagggctcc tttttatttt
    27301 ataagcagtt tatactcttc gaaaatctct tcaaaccgcg tcagcttcca tctgcaacct
    27361 caaaacagta ttttgagctg acttcgtcta gcttcttagt ttgctctttg atttttattg
    27421 agtgttaaat tatttcactg tcaaagtata tcttttttag gatcagaaag caagaaaaaa
    27481 tcgactgaaa gtgtctcagc cgataagaaa ggctcgcttt aggctagaaa gcatcttatt
    27541 ttcttcattg aaaaaagcct ttctttctgc tataatcgta taaaatactt actttaggag
    27601 ttcttatgaa agttgttaaa tttggaggta gttctcttgc ctctgctagt caattagaaa
    27661 aagttttaaa catcgtcaaa agcgattcag agcgtcgttt tgtagtcgtt tctgcgcctg
    27721 gtaaacgcaa tgctgaagat actaaggtta cggatgccct gattaaatac taccgcgact
    27781 atgttgcggg taacgatatt agcaagagcc aaagctggat tatcgaccgc tatgctgcta
    27841 tggttagtga attgggacta aaaccagctg tgctagaaaa aatttctaaa agcattcacg
    27901 ccttggccac tcttcctatt gaagaaaatg aatttctcta cgatactttc ctagcagccg
    27961 gtgaaaataa caatgccaaa ttgattgctg cctactttaa ccaaaatggt atcgatgcac
    28021 gctatatgca ccctagagaa gctgggattg tggtcacaag tgaacctggt cacgctcgca
    28081 tcattccatc aagttatgac aagattgaag aattgacaaa caccaatgaa gtccttgtca
    28141 ttcctggttt ctttggtgtc actaaggaaa atcaaatctg tactttctca cgtggaggtt
    28201 ctgatattac aggttctatc attgctgctg gtgtcaaagc tgacctctat gaaaacttta
    28261 cggacgttga tggtatcttt gcagctcacc ctggtattat ccaccaacca cactcgattc
    28321 ctgagttgac ctaccgtgaa atgcgcgagt tggcctatgc aggcttctca gtccttcatg
    28381 acgaggctct tcttcctgcc taccgtggaa aaattcctct ggttatcaag aataccaaca
    28441 accctgacca tccaggtact cgtatcgttc taaaacacag taatgatgaa tttccagttg
    28501 tgggaattgc tggtgactca ggctttgtca gcattaacat gtcgaaatac ctcatgaacc
    28561 gtgaggttgg atttggccgc aaggttctgc aaatcctgga agaacttaac atcggttggg
    28621 aacatatgcc aacaggtatc gacgatcttt ctatcattct ccgttctcgc caactaactc
    28681 ccatcaagga agaagaaatc ctgcgtcagt tggttcaaaa ggctaaagta gatcatgcag
    28741 aaatcgaaca cgacctttct atcattatga ttgttggtga aaaaatgaag agccatatcg
    28801 gagtgactgc tactgcgaca cgcgctctat ctgaaaacaa aatcaacatc cagatgatgt
    28861 ctcaaggttc tagtgaagtt tctattatgt ttgttgtcaa taaagaccaa gagaaagcag
    28921 caattaaagc cctctacaat gccttttttg gagaaagtaa ggaagactaa gcatggctca
    28981 atcacttaac aaaacagtac tcctcagtac gacaggcact tcctacctct ctatcgctgg
    29041 gaaagttggg aaattccttg tcggagatca ggctttggaa ttttacccag atgtcaatgt
    29101 cgaacaattt atccagattc cttggagcca tatcaatcag attggagcca atgtcactgg
    29161 atgcaaaatc agccgccact tcgaagtctt tacagacaaa ggaaaattcc tctttgcttc
    29221 aaaagactca ggtgccattc tcaaaattgc acgcgaaaaa ctaggcaatg acaaggtcgt
    29281 caaacttccg accctgattc agacaattag ccaaaaattt aaaaatctat ttgcaaaaaa
    29341 gtagaaactt tagtataatc atagcaacgg ataagtaggt tatcttcttc tttcagaaag
    29401 tctgcgggta ctgcgagcag ataggaggga taggtgaaat tctaccgtta gtaacaatta
    29461 catacacaat caagtgcaca cctgtgaagt tggatggaac cgtggccctg ccactccaac
    29521 gttttgtcag gcgtgctttt ttcataaagg agttcttatg ttagatatca aacgtattcg
    29581 tacagatttt gaagctgtcg cagaaaaatt agctacacgt ggtgtagatg ctgctgtctt
    29641 gaatgaaatg aaagaaatcg atgctaaacg tcgtaacatc ttggtcaagg ttgaaactct
    29701 caaagcagaa cgtaacacag tttctgctga gattgcccaa gctaagcgca acaaggaaaa
    29761 tacagatgac aagattgctg ccatgcaaaa tctatctgct gaggttaaag ccttggatgc
    29821 tgaattggca gaaatcgatg ctaaattgac agaatttaca acgactcttc caaatatccc
    29881 agctgacagc gttcctgttg gggctgacga agacgacaat gtggaagttc gccgttgggg
    29941 tactccacgc gagtttgact tcgaacctaa agctcactgg gatctcggtg aagaccttgg
    30001 tatccttgac tgggaacgcg gtggtaaggt aacaggcgct cgcttcctct tctataaagg
    30061 cctcggtgct cgtttggaac gtgctatcta caactttatg ttggatgaac atggaaaaga
    30121 aggctatact gaagtcatca caccttacat agtcaaccat gattctatgt ttggtactgg
    30181 tcagtatcca aaatttaagg aagatacttt tgaactcagc gataccaact ttgtcttgat
    30241 tccaactgct gaagttcctc tgacaaacta ctaccgtgat gaaatcttag acggcaaaga
    30301 tcttccaatc tacttcactg ctatgagtcc gtcattccgt tctgaggctg gttctgccgg
    30361 tcgtgatacg cgtggcttga tccgtttgca ccaattccac aaggttgaaa tggtcaaatt
    30421 tgccaaacca gaagaatctt acgaagaatt ggaaaaaatg acagccaacg ctgaaaacat
    30481 tcttcaaaaa ctcaaccttc cataccgtgt cgttgctctc tctactggag atatgggctt
    30541 ctcagctgcg aagacttacg acttggaagt gtggattcca gcacaaaaca attaccgtga
    30601 aatctcaagc tgttcaaaca cagaagattt ccaagcccgt cgtgcccaaa tccgttaccg
    30661 tgatgaagca gatggcaagg tgaaactcct tcataccttg aacggttctg gacttgcagt
    30721 tggacgtaca gtggctgcaa ttcttgaaaa ttaccaaaat gaagatggtt ctgtgaccat
    30781 cccagaagca cttcgtccat acatgggtgg agctgaagtc atcaaaccat aaaaaataag
    30841 gtttagctat ttctagctag accttttttc gtaaccaaat cagataagca cctagtacaa
    30901 agaataaaat agttaggcat ataatggttt cagccaatac caggtaatcc agaaatggaa
    30961 gtttcaaaat tccctgagtc atcttgagcg aggtcgctgt gataatggtt gggaaggtga
    31021 gggctgagaa ggctggttga aaaccttgtt ttaaaatgtt gggcagacga gttaaaacaa
    31081 agaaaaagaa ggattgagaa gccaaaatca tgacaatcaa gacccaagtc ggcaggctgg
    31141 ttcctcctac tcgaactaga gaagccaaga gtagagagaa aggagcacag tagattcctt
    31201 cttgtccaag caaggctagt gggagtggat gtttctttaa atcgctataa ataaggggat
    31261 agagatagaa ggtcaagaga aaaccaaaac tcaaggtcgc ataggcaatt tcgataatac
    31321 ctaccagagg ataggtcaag gcagccactg ctatccccac atagagaacc gtccagcttg
    31381 gagtggcatg aaccctccgc cctggacaag caaacttgat ggtaaaacca gcaatcaagg
    31441 tcaaatccaa gagaaatgaa aaccaccaaa tcccttgtgc taccaaagga agataagaga
    31501 atacgcgaaa gacataggtc gataaaatca tcccagccat aggaaaggtt gccattcctg
    31561 acaaaagagg gggcttggtc aattcttgct tggtttcttt ccaattaaag agatgcagaa
    31621 ttagaaagta aatccataaa accaaaccag tcagactaaa aagatgggat agaaccggca
    31681 acgtatctaa aataagattt ccagctcctg ccaaacctag caaacaacct gaaaatacta
    31741 aggggagttt tttcatccta acctccaata atcatgttag tttcagtata acataaaagc
    31801 gcttaaatga ggatttaaaa aaacgaagtc cgcttatttc agacttcatt ttactcagat
    31861 atgaattagg cataaggttg caattctgga ttaattggtg tattagctaa gttgttggca
    31921 tagttacaga ggattgctag gctgacacca aaaaccacat ccaaggcatt ttgttgagtg
    31981 tagccagctt ctaaaaactc agacaaggct tcatctccta cacgaccctt ggtattgata
    32041 actgccaagg taaacttagc tagggtatcc aatttaggat ctgtttcaat tggagtacga
    32101 ttgcgaagag cttgaatcaa gtcatcattc atctggattt gtttgatgga aaaggctgtg
    32161 tgacctgcga cacagaaggc acaaccattg gtcacggctg ccgtgatttg caccacttca
    32221 cgctcaacgg gtgtcaggct gttgcgacgg tggatagatg agacaatttg gtaggcttct
    32281 aaaacagtcg gggcattggc caagagaccg attaggttgg gaatatagcc attgttgtct
    32341 ttttctactg tttcaagaat ttctttcact tctgctggtg ctgactctac tgtatggata
    32401 gtaaatgttg tcataagata cctcttttct tattattgac actaatatta ttggaaaatc
    32461 ttataaaatc ctgattccta agtttatcta agataaagct ttattctctc ataagatttt
    32521 cgttgttata ttagtttatc acacttccaa tcacttgcat aatatatatt atatatcagg
    32581 ctgataaaaa ttatttatag gcaaaaaaat cacacgagct gtgtgattcc attatttgtc
    32641 aaaatacttt ttagtttcag caataacgac tggcgacaag accaagaggg caatcaagtt
    32701 tggcagagcc atcaaggcgt taacgatatc tgcgataatc cagaccatat ccaactcgat
    32761 aaatcctcct aacaagacca tgagcacaaa aaccacacgg tagagccaga taaagcgaac
    32821 cccaaagagg aactcaaaac agcgttctcc gtaatagttc caacctagaa tcgttgtaaa
    32881 ggcaaaaagt acaaggaaga tggtcaagag ggcaggccca aagtgtgaaa agactgttga
    32941 gaaagctgac tgagtcaagg caaccccatt caagtcacca ctccaaactc cagttaccaa
    33001 gatggtcaaa ccagttagag tacaaatgat gagggtatca ataaaggttc ctgtcatgga
    33061 aatcaaacct tgctctactg gttcatttgt cttggcagct gcaataggag cagaacccag
    33121 accagattcg tttgagaaca caccacgcgc cacaccattt tgaatagcca tccgaacgct
    33181 agcaccagca aatccaccta ccgcagcaag gggactaaaa gctgaggtaa agactaaagc
    33241 gattgtgcca gggatttttc caatattaaa gaaaataact gtaagagttc ctaagatata
    33301 aatgatggcc ataaaaggaa caacagtagt tgaaacctta gaaatagact tgagtccacc
    33361 aaagactgca atcgctacaa agacagacaa gacgagagct gtgatggctg gcgaaatcgt
    33421 cgttgtattt tggatagatt ctgcaatcga gttgacttgg gtgaaggttc cgattcccaa
    33481 gagagcaacc aatactcctg ctactgcaaa caaaacagca agtggtcgcc acttttctcc
    33541 catccctaga aggatataat gcatgggacc tcccgctact gcaccatggt cgtccttggt
    33601 gcggtatttg atggccaaga gtccttccgc atacttggta gccattccaa agaaagccgc
    33661 catccacatc caaaatagag ctcctggtcc accaaccttg atagccgtcg caactcctat
    33721 gatatttcct gttccaacag ttgatgccaa ggctgtacac agagctgcaa aactggatac
    33781 atcaccatgt cccttatcct ggataaaaat aagctgaaaa gccttgggca gacgcaaaac
    33841 ctgcaagagt cctagccgaa tagttaggta aatccctgtt ccgaccaata aaatcaagag
    33901 gggcggtccc caagcaaaag catcgattga tttaagcaat tctaacattt ccttctccta
    33961 tcgtttcaac cccaaaagaa agagcacatg caagatacat gtactctgga atgcttagat
    34021 aaatgctaaa aagcggtcta tcctagctct gtccttttac ctgagagttt gagcagttgc
    34081 ctgccttgcc ccttcggtgc ctttacggtc tctccagagt tccgtccatt tacagtcatg
    34141 gaaaatcaaa cgattcccca cttctattaa acttcattcg gtgttggtat ttaattgatt
    34201 ctaattttac aaaaaatgtt ggcttttgtc aatgtgttta ttagtaaaaa ttagttcaac
    34261 agtttttact ttataaagtc cagaatactg ctatccttta aaagtgacaa tagtcgcacc
    34321 actgcctcca gcattttgtg gggcatagcc gaaactcttg acatgtttgt ttctttgcaa
    34381 gtatttggta actccttcac ggatgactcc tgttccgata ccatggatga tatcaacttg
    34441 agccatattg ttaagcaagg cttggtcgat gaagatatct agctcattca tggcttcttc
    34501 atagcgcttg cctcgaagat ccagtctagc ttgaggtcct cgcccagaag ttcgtttcac
    34561 aacattgacc tgcttcttct tgactggttt ttcttgctgg gcttgaacaa gatcaaactc
    34621 tttctcttcc aaggtcatct taatcaagcc aacttgggct tcccagcggc cgtccttgag
    34681 ttgactggtc aaggtaccac gctgaccata actgagaacc acgatatcat ctcccacctt
    34741 tggagctcgt tttttcttgg ccttttgaag gaccttgttt ttagacaagt ccactttttc
    34801 aggagccaat tttttcaact tggccttggc ttcaatgatt tcgtggggct tgagttggga
    34861 tttactgtgg agatttttga gaatctggtc actttcactt agggccatat ccacaatctc
    34921 agcagcctgt tcacgcgcct tgttaagctc ggtttccttt tcacgattaa gctcgttgta
    34981 gagttttttt agcgcacggt tcatcttgag attttcttgc tccacctcac ggatattgtc
    35041 caagcgtttg cggctttcca gcgtctgctc ttctaattgc tcaatgatac gattgacgtc
    35101 attgtcctga tcgatctgct gactggcatc tcctacgata acttcagata ggcctagacg
    35161 tttggcaatt tcaaaggcat tacttcggcc aggaacaccc tgcataaagc gataggtcgg
    35221 gcgaagagtt gcagtatcaa actccatact ggcattttgc acaaaggctg tctcaatacc
    35281 gtaggccttg agttctggat agtgggtcgt cgccatggtc ttgatttgac gcaggcgaag
    35341 gtcctccaga atagccatgg caagggctgc tccctcttgg ggatcagtac cagcccccaa
    35401 ctcatccaaa agtaagagtg aatgttggtt gaccttgcca agaatatcca cgatattggt
    35461 catatggcta gagaaggtag acaagctctg ctcaatagac tgctcatctc caatatcagc
    35521 aaagatttct tcaaaaatac caacacgact tcccctgtct gctaaaatcg gcaatcctga
    35581 ctgggccatg acctgtgtca agcccagagt tttgagcatg atggtcttcc cacctgtatt
    35641 gggacctgta atgacaatag ctgttaaatc ttgaccaaaa tggacatcat ttgcgacggc
    35701 atttttgacc aaaggatggc agacatggag cagttgaatc tcttgatttt ctgacagctg
    35761 aggcacgact gcttgtcttt cttggataaa tcgaaccttg gcacgaatca agtccagatg
    35821 accgataatc caagcgtcat tagcaatctc agtcgcatga gggcggacac gctcagaaat
    35881 ttcttggaga atgcgaagca tttcatagcg ctcatctgct cgcagactag caatttcttc
    35941 gctcagtttg actacctcac gtggttcgat atagacggtg tttccactag cagaaatatc
    36001 atgaacgaca cctgcaatct tattgcggta ggtgtttttg actggtaaaa cctgacggcc
    36061 atttctgcta gcaacaattc cttctgtcaa catctgcgct ttttgcttga gcaagtcttg
    36121 taaaacatcg cgtacctgac tctcgctatc atgtattttt cgacggattc gcgccaattc
    36181 ttcactggca aaattttcaa tgaaacccgc atcattaaag gcctgaagat ttccttgtaa
    36241 ttgcggaaaa tcatgtaatt tctcaaacca aagggctaat tcttccaagc tgacattttc
    36301 cagattggcg taaaaacttt gaagttctcg gctggcaaga agcacgcgtt tcaagagtag
    36361 gaactcctcg atattgagat ccgctcccat ctccaacctc ttgcagactc ctgcaatttc
    36421 cttagttgag agaatagtaa aatgcggttg ctcgacgaaa agagcctgca tttccttcat
    36481 ctcagcaaaa gcctgtttga ttttatctgc tttggcagtc ggagccagtt gtctcaattg
    36541 ctccaagccc tgctcggtca acaaatgagg ctcaaacaag gccttgacct tatcgaactc
    36601 taatgtttct aatattttct tattcatctt tatttccttg tctttgaatg tctaggtgtg
    36661 gtagcttttt acattctgat agattcgagt caaatctgta aacaaagggc taggaaaact
    36721 cctgcccttt ttatccgatt aaatttgtca cccagatttg tttgagccaa ctggttgtta
    36781 tcggtatgct ctggatgatg tgttttgcga cgatactctt ttcaagagga ttttgtataa
    36841 ctgccatggg gatggtcgcc aagattgtca aggccatttg caagacaaat aaggtcacca
    36901 acatggacaa gatacctgct gaaacttgga acaacttacc acccagtttt ttgctaggaa
    36961 tcaagtgtaa gagaagacca agcaaacgac caatgctata gacaatccca aatacaagca
    37021 agtagccgat gcctgcataa aagaccttat ccagctgaaa gagttgatcc gatgggaaaa
    37081 agaaagtccc ctgaccttcc tgcgaatttg cataagggag caataaatgg aattgctctc
    37141 caagcccctt ataaaactgg ccagccataa aagccgatgc catggctgaa atcaggtaat
    37201 aaacctgtaa gagcaggcct ctccgatagc cgatataaaa tccccaaacc aagaccaata
    37261 gaagaaggaa tgaaatcata aggaatcctc aatcttgctc tgttcttgct tacaagtcac
    37321 aagcttgtga cggagttctt ctagctcttg ctccttatcg tcaaattcaa tctcacggct
    37381 gagctgagtt gataaacagt tgactgccaa caaaagagcg attgtttcat catctgcgct
    37441 aggcatttgt tctttaattg cttggtattt ttctgtcgca accttagcga tttcctccat
    37501 aaaaaggtta tcatgttcgc ttgtcaaggt taacgatttt ttcccgaatg taaatttgaa
    37561 tcgatttaga tttgccataa aattcacctc acgatattat accaaaattc gctaattttg
    37621 tcagttttta caaattttac tgcttttgtg gtacaataga aactatggca agtatcacac
    37681 tcacaccaag cgaaaaggat attcaggctt ttcttgaaca ctatcaaacc agtctggctc
    37741 ctagcaagaa tccctatatc cgctactttt tgaaactacc tcaagcaacg gtttctatct
    37801 atacttctgg aaaaatcttg cttcagggtg aaggggctga aaaatacgcc agtttctttg
    37861 gctatcaagc tgtagagcaa accagcggac aaaatcttcc tttaattggg acagatgagg
    37921 tgggaaatgg ttcctacttt ggtgggcttg cagttgtggc tgcctttgtc acacctgacc
    37981 agcacgactt tttacgaaaa ctcggtgtgg gggattctaa gactctgacc gaccaaaaga
    38041 tccgtcagat tgctcctatt ctcaaggaaa aaatccagca ccaggcactc cttctctcac
    38101 ccagcaagta caacgaggtc atcggaaacc gctacaatgc tgtttcggtt aaggttgccc
    38161 tccataatca ggctatctat ctcctccttc aaaaaggtgt tcagcctgag aaaattgtga
    38221 ttgatgcctt taccagtgct aaaaattatg acaagtactt ggcacaagag accaatcgtt
    38281 tcagcaatcc tatcagctta gaagaaaagg ctgagggcaa atacttggct gtcgcagttt
    38341 cttctgtcat tgcgcgtgat ctctttctgg aaaatcttga aaatttggga cgagaactgg
    38401 gttatcagct tccaagtgga gctggaacgg cttctgacaa ggtggctagc cagattttgc
    38461 aagcctatgg tatgcaggga ctcaacttct gcgccaaatt gcactttaaa aacactgaaa
    38521 aagcgaaaaa acgcttagaa aggtaagtta tgaattcatt taaaaatttc ttgaaagagt
    38581 ggggactgtt cctcctaatt ctgtcattac tagctttaag tcgtatcttt ttttggagca
    38641 atgttcgcgt agaaggacat tccatggatc cgaccctagc ggatggcgaa attctcttcg
    38701 ttgtaaaaca ccttcctatt gaccgttttg atatcgtggt ggcccatgag gaagatggca
    38761 ataaggacat cgtcaagcgc gtgattggaa tgcctggcga caccattcgt tacgaaaatg
    38821 ataaactcta catcaatgac aaagaaacgg acgagcctta tctagcagac tatatcaaac
    38881 gcttcaagga tgacaaactc caaagcactt actcaggcaa gggctttgaa ggaaataaag
    38941 gaactttctt tagaagtatc gctcaaaaag cccaagcctt cacagttgat gtcaactaca
    39001 acaccaactt tagctttact gttccagaag gagaatacct tctcctcgga gatgaccgct
    39061 tggtttcgag cgacagccgc cacgtaggta ccttcaaagc aaaagatatc acaggggaag
    39121 ctaaattccg cttctggcca atcacccgta tcggaacatt ttaagagacc taagaggccg
    39181 agaatcacca atctcagcct cttcttctat cgtgagaaaa tgattggtaa ctatctaaac
    39241 ttaccagaac agaaacacct caactctcac ctattcatgc aaaggaattt tatggaagtt
    39301 tatttttcag gaactattga acggattatt tttgaaaatc ccagcaattt ttatcgcatc
    39361 ctcctcctag aaatcgacga tacggacgca gaggattttg atgattttga aatcattgtc
    39421 acaggaacca tggctgatgt aattgagggc gaagactata ctttttgggg gcaaattgtc
    39481 cagcactcca agtatggaga acaactgcaa atcagtcgtt atgatcgcgc aaaaccaact
    39541 agtaagggct tggtcaagta cttttcaagt agccatttca aggggattgg tctcaagaca
    39601 gctcagaaaa tcgtggatac ctatggcgaa aataccattg acgaaatttt gcaacaccca
    39661 gaaaagttag aaggcatcgt aggactctct gccaaaaatc gcgaggcttt cgtctccact
    39721 ctccgtctca actacggaac ggagatgatt ttggccaaac tagccaacta cggcattccc
    39781 aacaaactag cctttcagat tcaagacttt tacaaggaag aaacccttga tgtggttgaa
    39841 aattatccct accagctggt tgaggatatc aagggtttgg gctttaccat tgctgaccaa
    39901 ctagctgagg aactaggcat cgaaagtcag gctcctgaac gcttccgcgc cggtctagtt
    39961 cacagtcttt ttcaggcctg tatggaaaca ggggacacct atgttgaagt acgggatttg
    40021 ctggaacaaa cccttactct ccttgagtct tcccgtcccg tggaactaga ccccagccaa
    40081 gttgcccaag agctctccta cctgatcgaa gaagacaagg ttcagcagat tgataccaag
    40141 atctttgaca acagcctctt tttcgctgag gaaggcatcc gcagtcactt ggttcgtatc
    40201 cttgaaaaag gaaaacagaa gagtcatgat ttagaaacca ttcaaaaaca tatcactact
    40261 atcgaggaag agctgggaat tgagtatgat aacattcaaa aacaggctat ctgtgatgct
    40321 atccagaata aggtctttat cctgacaggt ggacctggta ctggtaagac aactgttatc
    40381 aatgggatca tcgctgttta cgccctgtta gagggacttg acctcaggaa gaaaagcaac
    40441 ctgcccattc ttcttgctgc tccaactgga cgagccgctc gtcgcatgaa tgaattgaca
    40501 ggcttgccta gcgcgaccat acaccgccac ttgggaatga caggtgacga tgataccagt
    40561 catctggaag attacctaga tactgacttt atcatcgtgg atgaattctc tatggtggat
    40621 acttggctgg ccaatcaact cttctccaat atctcttcta acagtaagat cctcatcgta
    40681 ggtgacagtg atcagctacc ttctgtcagt cctggacagg ttctagcgga tctgcttcat
    40741 attcctttga ttcctcagac tcgcttggaa aaaatttatc gacaaagcga agaatcaacc
    40801 atcgtcaccc tagctagtca gattcgacag ggcatcttgc cagctgattt cacccaaaaa
    40861 aaagctgacc gttcctactt tgaaattgct agtggccata ttcctgccac cattgaaaaa
    40921 atcttaggtg ccgccctcag aaatggtatt cctgcccgtg atatccaagt tctggctcct
    40981 atgtaccgag ggacggcagg gattgatgct atcaatcagc tcatgcaaga cctgctcaat
    41041 cccccacaaa aagatcaact cagttttgaa gctcctcagt gccactatcg taagggagac
    41101 aaggtcattc atttggttaa cgatactgaa atcaatgtct ttaatgggga tttaggagct
    41161 atcacagacc tgattcctgg taaatacacc gaatcgaaac aagacgagat tgtcattgat
    41221 tttgatggta atgaagtctc ttacccccgt aacgaatggt acaagattcg cttggcctat
    41281 gccatgagta ttcataagtc tcagggaagt gagttcccag ttgtcatcct accgattact
    41341 agtgctagcc gacgtatgct ggagcgaaat ctcatctaca cagccattac acgtgccaaa
    41401 agcaaactca tcttactagg cgaattacaa gccttcgacc atgctaccca acacatcgga
    41461 actgcccgaa aaacctatct ggttgaacgc ttcagtgatc tactgaagaa tgttgaagaa
    41521 aagcaacaag ctgtctctga aacagtcaca tcaagtgcct ctgaacaatc ctacatccta
    41581 accgaagaaa actgggaccg catcccagcc atgattggga ttacagacac agacctcaaa
    41641 gagatttttg gaaaatagtg catcagaaaa cccacctgaa ttggtgggtt ttctgtttat
    41701 taagattatt ttactgttgc tgtgcttgta atcaattcaa cagctttttt gattgtgata
    41761 tcatgtttca acatgtcagc tgaaagcaag ttttgaactt gtgcaacttc catgttgtag
    41821 tctgctgcca attgctcaac ttctttttgg atttcttctt ctgaagcatc aaatccttca
    41881 gctttggcaa ctgcttcgat aacaaggtta gtcttagtac gtgactcagc ttctgcttgg
    41941 tattggttgt gaaggtcttc ttgagtagtt ccagtaattt ggaagtacat gtcagggttg
    42001 atcccttgac gttgcaagtt cccaaggaat tcatttactg aacggtgaac ttcttcgtgg
    42061 atcatttctt ctggaagttc tacgatttca gcattttcta cagctgtatc aattgctgca
    42121 ccttcaactg catctttgta agcttcttct ttagcagcag ccaattcttt gcggtatttt
    42181 tctttcaagt cagcaagtgt ttcaacttct tcatcaatgt cttttgcaag ttcatcgtca
    42241 agagctggaa cttctttagc ttttacttcg tggatagttg tcacgaattt agcttcttta
    42301 cctgcaaggt cttctgcttg gtagtcttct gggaatgtta cgataacatc aacggtttcg
    42361 ccagctgagt gacctaccaa ttggtcttcg aaaccaggga tgaattgacc tgaaccaagt
    42421 ccaagtgaga agttttcacc ttttccaccg tcaaattcaa caccgtcgat agaaccaacg
    42481 aagtcgatca caacagtgtc gccgtcttca gcagcagctt ccttgataac caattcagcc
    42541 aggttgttgc gttcgcgttc gatacgctct tcgacatcag cgtcagttac ttctttttct
    42601 acatcaactg atacttcaag gtttttgtag tcacccaatt ttacttcagg ttttgtaaca
    42661 acttcagcag cgataaccca gtcttgacct ttttccattg aagttacgtc aatttttggt
    42721 tgggcaacca cttcaagacc agcttctttt acagctgctt cataagcgtt tggcaaaaga
    42781 gcgttcataa cgtcttggta aagtgattct tcaccaaatt ttttatcgaa gataggacgt
    42841 ggaaggtgac ctttacggaa acctggaaca ttaagagatt tcttcactga cttgaagaca
    42901 cggtccaatt ctggtttgat ttggtcttga gagatagtga aagtcaagac accacggttt
    42961 gtttctttgt tttcaaatga tacagacatt ctgtcatttc tccttaaaat tttttaaata
    43021 cagtctatta taacattttc tataaataaa atctagacta atgcagacaa ttatagacaa
    43081 caagcctttt tcctaactaa aacactcata aagtatagac aattttagac tactttggat
    43141 atcttttggt tagtca
//
LOCUS       DAVHIZ010000014        42385 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.014, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000014 DAVHIZ010000000
VERSION     DAVHIZ010000014.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 42385)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 42385)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..42385
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.014"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..71
                     /locus_tag="VVO18_000749"
     CDS             <1..71
                     /locus_tag="VVO18_000749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="PTS fructose transporter subunit IIB"
                     /protein_id="HEU5585947.1"
                     /translation="IPAMSAPVFDNIEAAIKEHGLS"
     gene            119..1594
                     /locus_tag="VVO18_000750"
     CDS             119..1594
                     /locus_tag="VVO18_000750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338710.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS galactitol transporter subunit IIC"
                     /protein_id="HEU5585948.1"
                     /translation="MDAIFDLIGKVFNPILEMGGPVIMLIILTVLALLFGVKFSKALE
                     GGIKLAIALTGIGAIIGMLNGAFSASLAKFVENTGIQLSITDVGWAPLATITWGSAWT
                     LYFLLIMLIVNVVMLAMKKTDTLDVDIFDIWHLSITGLLIKWYADNNGVSQGVSLFIA
                     TAAIVLVGVLKIINSDLMKPTFDDLLNAPSSSPMTSTHMNYMMNPVIMVLDKIFEKFF
                     PGLDKYDFDAAKLNKKIGFWGSKFFIGFILGIVIGIMGTPHPIAGVADADKWRLVIKG
                     WLSLGLTAGVSLELFSLIGSWFIAAVEPLSQGITNVATKRLRGRKFNIGLDWPFIAGR
                     AEIWACANVLAPIMLIEAVLLSKVGNGILPLAGIIAMGVTPALLVVTRGKLLRMIIFG
                     TLLLPLFLLSGTLIAPFATELAKGVGAFPEGVSQTQLITHSTLEGPIEKLLGWTIGNT
                     TTGDIKAILGAVVFLVFYIGIFAWYRKQMIKRNEEYAAKAK"
     gene            1944..8645
                     /locus_tag="VVO18_000751"
     CDS             1944..8645
                     /locus_tag="VVO18_000751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Ig-like domain-containing protein"
                     /protein_id="HEU5585949.1"
                     /translation="MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVY
                     ADETLITHTAEKPKEEKMIVEEKADKALETKNVVERTEQSEPSSTEAIASEKKEDEAV
                     TPKEEKVSAKPEEKAPRIESQASSQEKPLKEDAKAVTNEEMNQMIEDRKVDFNQNWHF
                     KLNANSKEAIKPDADVSTWKKLDLPYDWSIFNNFDHESPAQNEGGQLNGGEAWYRKTF
                     KLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLHKDGRENVI
                     AVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVT
                     SKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLW
                     TVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLH
                     HDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFD
                     TWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIG
                     EANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNY
                     SEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDR
                     VGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAG
                     IPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVE
                     LFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEI
                     ARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHG
                     QGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLK
                     SSQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPTTVPFLYSDGSRAERPVTWSS
                     VDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTDLNSVDKSVSYVLTD
                     GSVQEYEVDSWEITEVDKAKLSVAGSRIQMTGQLAGETIHATLVVEEGNAAAPVVPTV
                     TVGGEAVTGLTSRQPMQYRTLSYGAQLPEVTASAENADVTVLQASAANGMRASIFVQP
                     KDGGPLQTYAIQLLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPAD
                     KVTFSTSGEGEVAIRKGMLELHKPGAVTLKAEYEGAKGQVELTIQANTEKKIAQSIRP
                     VNVVTDLHQKPTLPTTVTVEYDKGFPKAHKVTWQAIPKEKLDSYQTFEVLGKVEGIDL
                     EARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYA
                     KEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVS
                     NVNDKLISYNNQPANRWTNWNRTNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVG
                     APKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHF
                     SFDKVETYAVRIRMVRADNKLGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPD
                     LTDYYLESVDGKVTAVTASVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFT
                     KDKNLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKNLTVEWEEVPAEN
                     LIKAGQFTVRGHVLGSNLVAEITVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKN
                     SHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVAQGKVQFFA
                     DSGTDAPSKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYRADKDIAAG
                     DEINVTFKDIKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELA
                     DFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSLPVLVRLVSESGKQVKEYR
                     IHLTKEKPVSDKTVAAVQEDLPKLEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKVGK
                     ERIFTAINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSE
                     ASQTNKAQLPNTGSAAGQAAVAAGLALLGLSAGLVVTKGKKED"
     gene            complement(8893..9742)
                     /locus_tag="VVO18_000752"
                     /pseudo
     CDS             complement(8893..9742)
                     /locus_tag="VVO18_000752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007722232.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(9953..10312)
                     /locus_tag="VVO18_000753"
     CDS             complement(9953..10312)
                     /locus_tag="VVO18_000753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004249826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3397 domain-containing protein"
                     /protein_id="HEU5585950.1"
                     /translation="MGMILMKLASILLLILTLVVCIILTKLFRLKKLGRNFADLAFPV
                     LVFEYYLITTKTFTHNFLPRLGLALSILAIILVFFFLLKKRSFYYPKFIKFFWRAGFL
                     LTLIMYIEMIVELFLMK"
     gene            10404..11360
                     /locus_tag="VVO18_000754"
                     /pseudo
     CDS             10404..11360
                     /locus_tag="VVO18_000754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002881980.1"
                     /note="This family includes YhcC from E. coli K-12, an
                     uncharacterized radical SAM protein.; internal stop;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01212 family radical SAM protein"
     gene            11344..11901
                     /locus_tag="VVO18_000755"
     CDS             11344..11901
                     /locus_tag="VVO18_000755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828405.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU5585951.1"
                     /translation="MKRPLEMAHDFLAEVVTKEDVVVDATMGNGHDTLFLAKLAKQVY
                     AFDIQKQALEKTQERLHQAGLTNAQLILQGHETLDQFVTKAKAGIFNLGYLPSADKSV
                     ITRPQTTIEALEKLCGLLVKGGRIAIMIYYGHEGGDLERDAVLDFVIQLNQQEYTAAI
                     YRTLNQVNNPPFLVMIEKLERYRHG"
     gene            11894..12148
                     /locus_tag="VVO18_000756"
     CDS             11894..12148
                     /locus_tag="VVO18_000756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000361102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585952.1"
                     /translation="MDKQYLHEKLDAMRQNFVESTYHERAVGVLDQAHMSKKMLKIKK
                     KLVALEMERCQRKIEHKDCSKIDQKIKEQKEIFESCCKKD"
     gene            12160..14214
                     /locus_tag="VVO18_000757"
     CDS             12160..14214
                     /locus_tag="VVO18_000757"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cation:proton antiporter"
                     /protein_id="HEU5585953.1"
                     /translation="MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFL
                     PNTDFHLNTELFLALVIGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGL
                     AHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
                     AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIAS
                     ELLLELSLPLVTFFLAEEVHVSGIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHT
                     VTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYY
                     AYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTL
                     VSFLTGLLVLPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLSLYAAIDNYH
                     GRIENLILSQENQDDQEDWAALKLLILSIESDGLEQAYEEGNISNRAYRVYQRYLKNI
                     EQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKNKEQSRLRALDYDQIAE
                     LYLANTEMIIESLENLKGVYRRSLISFMQESRLRETAIISSGAFVERVINRVKPNNID
                     EMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVR
                     RN"
     gene            14393..15253
                     /locus_tag="VVO18_000758"
     CDS             14393..15253
                     /locus_tag="VVO18_000758"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="HEU5585954.1"
                     /translation="MKKWWKELIDKPLLKAFLHYYQASDSELTSVAVAYYWLISIFPL
                     LLVVVNILPYFQIPVGEFLCFMKDVLPPSLYEGVEKIAREVLTQPSTGLLSFSVLSAL
                     WSFSKSMNFLQKAFNKAYGVEKSRGLISHQMLSLLVSFGLQLLFAFALFLILFGQMIL
                     ALLAHYWTKDGIIYQALQGLAGPLIYALLFAILVMLYYFLPNISNRKISYTLPGSAFV
                     LLVILGLLTLFSSYLNYYVHHLVDVRILGSVLLVVMMFWFILIAKIVILGAVINASMQ
                     SLRDPVFKKD"
     gene            15464..16174
                     /gene="ccdA2"
                     /locus_tag="VVO18_000759"
     CDS             15464..16174
                     /gene="ccdA2"
                     /locus_tag="VVO18_000759"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000509848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEU5585955.1"
                     /translation="MGHIFFFLSVFLAGILSFFSPCILPLLPVYTGVLLDDKDGAQAS
                     SGKFSISVTSLLRTLAFIAGISFIFILLGYGAGFLGDLLYASWFQYLTGAIIILLGLH
                     QMEILHFKGLYKEKRLQLQGQGQNGKGYSQAFLLGLTFSFAWTPCVGPVLGSVLALAA
                     SGGSGAWQGAGLMLVYTLGLALPFLLLALTSSYVLKHFRKLHPYLGILKKVGGFLIIV
                     MGLLVLFGNASILSQLFE"
     gene            16194..16760
                     /locus_tag="VVO18_000760"
     CDS             16194..16760
                     /locus_tag="VVO18_000760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redoxin family protein"
                     /protein_id="HEU5585956.1"
                     /translation="MKKWQTCVLGAGSLLCLTACSGKSVTSEHQTKDEMKTEQTASKT
                     SAAKGKEVADFELMGVDGKTYRLSDYKGKKVYLKFWASWCSICLASLPDTDEIAKEAG
                     DDYVVLTVVSPGHKGEQSEADFKNWYKGLDYKNLPVLVDPSGKLLETYGVRSYPTQAF
                     IDKEGKLVKTHPGFMEKDAILQTLKELA"
     gene            16771..17883
                     /gene="msrB"
                     /locus_tag="VVO18_000761"
     CDS             16771..17883
                     /gene="msrB"
                     /locus_tag="VVO18_000761"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEU5585957.1"
                     /translation="MNDKLKIFLLLGVFFLAITGFYVLLIRNAGQTDASQIEKAAVSQ
                     GGKAVKKTEISEDADLHEIYLAGGCFWGVEEYFSRVPGVTDAVSGYANGRGETTKYEL
                     INQTGHAETVHVTYDAKQISLKEILLHYFRIINPTSKNKQGNDVGTQYRTGVYYTDDK
                     DLEVINQVFDEVAKKYDQPLAVEKENLKNFVVAEDYHQDYLKKNPNGYCHINVNQAAY
                     PVIDASKYPKPSDEELKKTLSPEEYAVTQENQTERAFSNRYWDKFESGIYVDIATGEP
                     LFSSKDKFESGCGWPSFTQPISPDVVTYKEDKSYNMTRMEVRSRVGDSHLGHVFTDGP
                     QDKGGLRYCINSLSIRFIPKDQMEEKGYAYLLDYVD"
     gene            18106..18843
                     /locus_tag="VVO18_000762"
     CDS             18106..18843
                     /locus_tag="VVO18_000762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864667.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5585958.1"
                     /translation="MTYTILIVEDEYLVRQGLTKLVNVAAYDMEIIGQAENGRQAWEL
                     IQKQVPDIILTDINMPHLNGIQLASLVRETYPQVHLVFLTGYDDFDYALSAVKLGVDD
                     YLLKPFSRQDIEEMLGKIKQKLDKEEKEEQLQDLLTNRFEGNMAQKIQSHLADSQFSL
                     KSLASDLGFSPTYLSSLIKKELGLPFQDYLVRERVKQAKLLLLTTDLKIYEIAEKVGF
                     EDMNYFTQRFKQIAGVTPRQFKKGEGR"
     gene            18840..20531
                     /locus_tag="VVO18_000763"
     CDS             18840..20531
                     /locus_tag="VVO18_000763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000831084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5585959.1"
                     /translation="MKRSSLLVRMVISIFLVFLILLALVGTFYYQSSSSAIEATIEGN
                     SQTTISQTSHFIQSYIKKLETTSTGLTQQTDVLAYAENPSQDKVEGIRDLFLTILKSD
                     KDLKTVVLVTKSGQVISTDDSVQMKTSSDMMAEDWYQKAIHQGAMPVLTPARKSDSQW
                     VISVTQELVDAKGANLGVLRLDISYETLEAYLNQLQLGQQGFAFIINENHEFVYHPQH
                     TVYSSSSKMEAMKPYIETGQGYTPGHKSYVSQEKIAGTDWTVLGVSSLEKLDQVRSQL
                     LWTLLGASVTSLLVCLCLVWFSLKRWIAPLKDLRETMLEIASGAQNLRAKEVGAYELR
                     EVTRQFNAMLDQIDQLMVAIRSQEETTRQYQLQALSSQINPHFLYNTLDTIIWMAEFH
                     DSQRVVQVTKSLATYFRLALNQGKDLICLSDEINHVRQYLFIQKQRYGDKLEYEINEN
                     VAFDNLVLPKLVLQPLVENALYHGIKEKEGQGHIKLSVQKQDSGLVIRIEDDGVGFQD
                     AGDSSQSQLKRGGVGLQNVDQRLKLHFGANYQMKIDSRPQKGTKVEIYINRIETS"
     gene            20647..21210
                     /locus_tag="VVO18_000764"
     CDS             20647..21210
                     /locus_tag="VVO18_000764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01440 family protein"
                     /protein_id="HEU5585960.1"
                     /translation="MNETQIQRETRQVVEDVLEKTNLKQGALFVLGLSSSEVLGGQIG
                     KESSQEIGELIVETILGILGSRGIHLAVQGCEHVNRALVVERQVAEQFGLEIVSVHPT
                     LHAGGSGQLAAFKFMQDPVEVEFIKAHAGLDIGDTAIGMHVKHVQVPIRPILREIGHA
                     HVTALASRPKLIGGARAHYPQDAIRKS"
     gene            21232..26940
                     /locus_tag="VVO18_000765"
     CDS             21232..26940
                     /locus_tag="VVO18_000765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU5585961.1"
                     /translation="MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEII
                     SQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKK
                     IASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLD
                     TVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVEAEEAPKEEAPKTEESPKEEP
                     KSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEES
                     KVEPPVEQAKGPEQPVQPTQAEQPRIPKDSSQPEDPKEDRGAEETPKQEDEQPAEAPE
                     IKVEEPVESKEETKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEV
                     VPDDTKYVDEEVVERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPAVPKVVKKG
                     TKPVKGTAVETREEVIPFATKEQEDDTLKRGTRQVAQEGVNGKKQITETYKTIRGEKT
                     NEAPTVEETVLQAPQDEIIKKGTKGLEKPTLEWVKTDKDVLKKSATASYTLNKPDGVE
                     IKSIKVALKDNTGTVIKEVTVEENNLNATLDNLKYYQGYTLSTTMVYNRGEGEETETL
                     EDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSLLTEKPTDVAPLYLRVTTHDNKT
                     TRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRREDDTLSEEYVHYFEKQLPKVDNVYYS
                     FNELITDMQKNPTGTFKLGADLNAANTPTPSKSYVTGEFKGKLSSVDGQHYTIHNTAR
                     PLFNNIVGGTVKNINLNNVNIDMPWADQIASVANVIKGGSLIENVKVKGNVLGRNWVS
                     GFIDKIDSGGRLVNVAFIGNVTSVGDGDKFLTGIVGENWKGYVEKAYVEANIKGKRAK
                     AAGISYWSQNSGDNNAVGRDGAIKKSVVKGSIDVEKPIEVGGAVGSLNYLGYIEDTVA
                     MMKVKNGEIFYGSHDIDTDPYYTGERVNRNFIVDGVSEGKSSYTYSKQQKRIKSISQE
                     EADKKIKELGITADKFTIIDPIVNKLNNIKQKADTYKDTQDYKADRELTYRNIEKLQP
                     FYNKEWIVDQGNKVPSNSKLLTTEVLSVTGIKSGQFVTDLSDIDKIMIHYSDGAKEEL
                     NVTRQESNVQQVREYSITDLDILYTPNMVEKDRAQLMTDVKSKLSSVELESDGVRQLL
                     VKRDTKKDANANSVGRQNGYIRDLFLEESFSEVKANLDKLVKQILENEDHQLNDNELA
                     ERALLKKVEDNKAKIMMGLAYLNQYYAFKYDELSIKDIMMFKPDFYGKTASVIDRLIN
                     IGSAENNLKGDRTQDAYRGIISGATGKGSLHDFLTYNMKLFTNETDINVWFKKAIEKN
                     AYVVEQPSTNPAFANKKYRLYEGINNGQHGRMILPLLNLKNAHLFMISTYNTISFSSF
                     EKYGKDTDEKREKFKSEINKRAKEQVNYLDFWSRLATDNVRDKLLKSQNVVPTPVWDN
                     HNSPNGWASRHGHIDGKPDYAPIREFFGRINKYHGYKYGYGAYAYIFAAPQPMDAVYF
                     VMTDLISDFGTSAFTHETTHVNDRMAYYGGHWHREGTDLEAFAQGMLQTPSVSNPNGE
                     YGALGLNMAYERQNDGNQWYNTNPNDLTTRAEIDNYMKGFNDTLMLLDYLEGEAVLNK
                     ANQDLNNAWFKKVDKQLRGASTKNQYDKVRDLTADEKNITLNSVDDLVDNNFMTKHGP
                     GNNVYDPTGFGTAYVTVPITAGIYGGNTSEGAPGSMSFKHNTFRMWGYYGYEKGFLNY
                     ASNMLKNESRQAGHNTLGDDFIIKKVSDNKFSTLEDWKKAYFKEVVDKAKAGFNPVTI
                     DGTTYSSYDDLKNAFAAAVEKDKATLKNGSVKSDNTVALKEKIYKKLLQQTDSFKTSI
                     FR"
     gene            27001..28722
                     /gene="pabB"
                     /locus_tag="VVO18_000766"
     CDS             27001..28722
                     /gene="pabB"
                     /locus_tag="VVO18_000766"
                     /EC_number="2.6.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="HEU5585962.1"
                     /translation="MHRKTVIDFRTLGERYTFTQPIKELKTRNVEEVADLLAQVESYQ
                     EQGYYVVGYVSYEAAPAFEEKLTVHKVPLLGEYLLYFTVHDRVETSPIPLTYEDIDLP
                     SNWQEVTSAADYEKAIAQIHHHLRQGDTYQVNYTVQLKQKLSANPFAIYNRMVVEQEA
                     GYNAYVEHDEMAVISMSPELFFEQNDRELTTRPMKGTTQRGVTDQEDLEQASWLEQDP
                     KNRSENMMIVDLLRNDMNRISEVGSEHVERLCQVEQYSTVWQMTSTIKSQLREDVDLV
                     EIFRSLFPCGSITGAPKIATMEIIKDLEPQPRGVYCGTIGLLLPNGRRIFNVAIRTIQ
                     LHKDQAIYGVGGGITWDSTWESEYREVHQKAAVLYRKQARFQLITTGKISQKNLLFED
                     QHLERLRKASRYFAFPFDAEDLGHKIEEECQDCEANRDYRLRISLSKSGEIEVNRQVL
                     TPLSTSFCQAQVCLQEAALNQSFTYFKTTHRPHLSLGEQEKIYHNKSGELLETSIGNL
                     VLKIAGKLYTPPIRLGILPGIYRQHLLETGQVEEKVLTLADLAQAEAIYGCNAVRGLY
                     ELSLEEN"
     gene            28723..29340
                     /locus_tag="VVO18_000767"
     CDS             28723..29340
                     /locus_tag="VVO18_000767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000766583.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU5585963.1"
                     /translation="MKLIFLHGLGQSAESWKEVRNLLTDYPSEAIELFPSGVSNYQQA
                     KERVYQHLAQETEPFVLIGLSLGAALTLELSSYDLPNLRALILSGCPLKLAGNILFYL
                     QLLIFKLLPKRVFEKQGADKTLMVGVSEELKTLDLTDIAGTCSYPTLLICGSKDKPNL
                     SSMKALHRLLTDSQFQIIPDGPHVLNKAKPKEFVEKTRSFLELLK"
     gene            29390..30388
                     /locus_tag="VVO18_000768"
     CDS             29390..30388
                     /locus_tag="VVO18_000768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEU5585964.1"
                     /translation="MNKRLFLKMSLVTLPILALFSQPVLAEENIHFSSCKEAWANGYS
                     DIHEGEPGYSAKLDRDHDGVACELKNAPKGAFKAKQAATTQTDTTSSTASGWVKQDGS
                     WYYFDGNGNLVKNAWQGNYYLKADGKMAQSEWIYDSSYQAWYYLKSDGSYARNAWQGN
                     YYLKSDGKMAKGEWVYDATYQAWYYLKSDGSYARNAWQGNYYLKSDGKMAKGEWVYDA
                     TYQAWYYLTSDGSYAYSTWQGNYYLKSDGKMAVNEWVDGGRYYVGADGVWKEGQASTA
                     SSSNDSNSEYSAALGKAKTYNSLFHMSKKRMYRQLTSDFDKFSNDAAQYAIDHLDD"
     gene            30515..31474
                     /locus_tag="VVO18_000769"
     CDS             30515..31474
                     /locus_tag="VVO18_000769"
                     /EC_number="2.7.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002919069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family glucokinase"
                     /protein_id="HEU5585965.1"
                     /translation="MSQKIIGIDLGGTSIKFAILTTAGEIQGKWSIKTNILDEGSHIV
                     DDMIESIQHRLDLLGLAAADFQGIGMGSPGVVDRDKGTVIGAYNLNWKTLQPIKQKIE
                     KALGIPFFIDNDANVAALGERWMGAGDNQPDVVFMTLGTGVGGGIVAEGKLLHGVAGA
                     AGELGHITVDFDQPIACTCGKKGCLETVASATGIVNLTRRYADEYEGDAALKRLIDNG
                     EEVTAKTVFDLAKEGDDLALIVYRNFSRYLGIACANIGSILNPSTIVIGGGVSAAGEF
                     LLQGVQKVYDENSFPQVRTSTKLALATLGNDAGVIGAASLVLQ"
     gene            31571..32410
                     /locus_tag="VVO18_000770"
     CDS             31571..32410
                     /locus_tag="VVO18_000770"
                     /EC_number="2.1.1.45"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003011065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidylate synthase"
                     /protein_id="HEU5585966.1"
                     /translation="MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAF
                     SEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDT
                     GTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMF
                     DVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNL
                     HIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFD
                     LAI"
     gene            complement(32457..32627)
                     /locus_tag="VVO18_000771"
     CDS             complement(32457..32627)
                     /locus_tag="VVO18_000771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001051775.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3042 family protein"
                     /protein_id="HEU5585967.1"
                     /translation="MAKGFAKGLVTGVAGTVAAVAGAVYAFKKKVIEPEEQKAAFIEE
                     NRKKAARRRVSR"
     gene            32748..33632
                     /gene="miaA"
                     /locus_tag="VVO18_000772"
     CDS             32748..33632
                     /gene="miaA"
                     /locus_tag="VVO18_000772"
                     /EC_number="2.5.1.75"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (adenosine(37)-N6)-dimethylallyltransferase
                     MiaA"
                     /protein_id="HEU5585968.1"
                     /translation="MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLD
                     IGTAKASPEEQAAVLHHLIDVREITESYSAFDFVSEAKMTIEDIHSRGKLAIIAGGTG
                     LYIQSLLEGYHLGGETPHEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRA
                     LEIAHFGQDLENQETLYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHS
                     PNVQAAKGIGYKELFPYFRGEQTFEEASESLKQATRRFAKRQLTWFRNRMQVTFYQIG
                     ESGVQDRILSQIEEFLDD"
     gene            33625..34863
                     /gene="hflX"
                     /locus_tag="VVO18_000773"
     CDS             33625..34863
                     /gene="hflX"
                     /locus_tag="VVO18_000773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000573186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase HflX"
                     /protein_id="HEU5585969.1"
                     /translation="MIETEKKEERVLLIGVELQGMDSFDLSMEELASLAKTAGAVVVD
                     SYRQKREKYDSKTFVGSGKLEEIALMVDAEEITTVIVNNRLTPRQNVNLEEVLGVKVI
                     DRMQLILDIFAMRARSHEGKLQVHLAQLKYLLPRLVGQGIMLSRQAGGIGSRGPGESQ
                     LELNRRSVRNQITDIERQLKVVEKNRATVREKRLESSTFKIGLIGYTNAGKSTIMNIL
                     TSKTQYEADELFATLDATTKSIHLGGNLQVTLTDTVGFIQDLPTELVSSFKSTLEESK
                     HVDLLVHVIDASNPYHEEHEKTVLSIMKDLDMEDIPHLTLYNKADLVEDFTPTQTPYT
                     LISAKSEDSRENLQALLLDKIKEIFEAFTLRVPFSKSYKIHDLESVAILEERDYQEDG
                     EVITGYISEKNKWRLEEFYD"
     gene            34856..35479
                     /locus_tag="VVO18_000774"
     CDS             34856..35479
                     /locus_tag="VVO18_000774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cystathionine beta-lyase"
                     /protein_id="HEU5585970.1"
                     /translation="MTDIKTLALKYGGYTSLDKVYLDQLLAGKTEQEQLTLITPPPSV
                     VNAYFAELYQKKSPQAATDYFAELSQELNLYNTEPSFTLENKPFIRLNLSGKSFGFCY
                     ESDGFGRIFSENEEKISDDLLFEIAQIFSHQLVFEESGKIYMKPVKDEEVVSLESLTA
                     LTDLERLADGRKRLKGYSQEDLLQEAAAFSGKRYFRSENRTAMLYID"
     gene            35494..36423
                     /locus_tag="VVO18_000775"
     CDS             35494..36423
                     /locus_tag="VVO18_000775"
                     /EC_number="3.1.26.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000354350.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Z"
                     /protein_id="HEU5585971.1"
                     /translation="MDIQFLGTGAGQPSKARNVSSLALKLLDEINEVWLFDCGEGTQN
                     RILETTIRPRKVSKIFITHLHGDHIFGLPGFLSSRAFQANEEQTDLEIYGPQGIKSFV
                     LTSLRVSGSRLPYRIHFHEFDQDSLGKILETDKFTVYAEELDHTIFCVGYRVMQKDLE
                     GTLDAEKLKAAGVPFGPLFGKIKNGQDLVLEDGTEIKAADYISAPRPGKIITILGDTR
                     KTDASVRLAVNADVLVHESTYGKGDEKIARNHGHSTNMQAAQVAVEAGAKRLLLNHIS
                     ARFLSKDISKLKKDAATIFENVHVVKDLEEVEI"
     gene            36444..37199
                     /locus_tag="VVO18_000776"
     CDS             36444..37199
                     /locus_tag="VVO18_000776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="HEU5585972.1"
                     /translation="MPTILITGASGGLAQEMVKLLPNDQLILLGRNKEKLAQLYGNYS
                     HAELIEIDITDDSALEALVTDLYLRYGKIDVLINNAGYGIFEGFDQIADKDIHQMFEV
                     NTFALMNLSRHLAARMKESSKGHIINIVSMAGLIATGKSSLYSATKFAAIGFSNALRL
                     ELMPYGVYVTTVNPGPIRTGFFDQADPDGTYLKSVDRFLLEADAVAKKIVKIIGKNKR
                     ELNLPILLNLAHKFYTLFPKLADKLAGETFNYK"
     gene            complement(37253..38161)
                     /locus_tag="VVO18_000777"
     CDS             complement(37253..38161)
                     /locus_tag="VVO18_000777"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator"
                     /protein_id="HEU5585973.1"
                     /translation="MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLENEMG
                     IEIFIRNPKGITLTRDGMEFLSYARQVVEQTQLLEERYKNPVAHRELFSVSSQHYAFV
                     VNAFVSLLKKSDMEKYELFLRETRTWEIIDDVKNFRSEVGVLFLNSYNRDVLTKMLDD
                     NHLLAHHLFTAQPHIFVSKTNPLAKKDKVKLSDLENFPYLSYDQGTHNSFYFSEEILS
                     QEHHKKSIVVSDRATLFNLLIGLDGYTIATGILNSNLNGDNIVSIPLDIDDPIELVYI
                     QHEKTSLSKMGERFIDYLLEEVQFDS"
     gene            38225..38494
                     /locus_tag="VVO18_000778"
     CDS             38225..38494
                     /locus_tag="VVO18_000778"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000051789.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqgQ family protein"
                     /protein_id="HEU5585974.1"
                     /translation="MSLFLKKTQNFARMSLMKTFYDVQQFLKRFGIIVYMGKRLYDIE
                     LMKLELSRIYDAGLMDKLDYLEAEAVLRREHKVELDYIEKNGEKN"
     gene            38494..38874
                     /locus_tag="VVO18_000779"
     CDS             38494..38874
                     /locus_tag="VVO18_000779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="HEU5585975.1"
                     /translation="MVTWILWALILAMLAWMGFNYLRIRRAAKIVDNEEFEALIRTGQ
                     LIDLRDPAEFHRKHILGARNIPSSQLKTSLAALRKDKPVLLYENQRAQRVTNAALYLK
                     KQGFSEIYILSYGLDSWKGKVKTS"
     gene            38963..39190
                     /locus_tag="VVO18_000780"
     CDS             38963..39190
                     /locus_tag="VVO18_000780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000660075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585976.1"
                     /translation="MKEKKKNPLFVGILSIILGLLFPIVGLILGIIGLVLAISYQKES
                     QLDYKIEKILNILGIVISVVNWIVAIALIFR"
     gene            complement(39230..39955)
                     /locus_tag="VVO18_000781"
     CDS             complement(39230..39955)
                     /locus_tag="VVO18_000781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001235004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rRNA pseudouridine synthase"
                     /protein_id="HEU5585977.1"
                     /translation="MRLDNLLAQEKISRKAMKQALLKGEILVDGCPARSLAQNIDTGL
                     QELLFQDRIIQGYEHTYLMLHKPAGVVTANKDKELPTVMDLLPSDIQSDKLYAVGRLD
                     RDTTGLLLLTDSGPLGFQLLHPQYHVDKTYQVQVNGLLTPDHIQAFQKGIVFLDGTVC
                     KPAKLEILSASPSLSQASITISEGKFHQIKKMFLSVGVKVTSLKRIQFGDFTLNPDLA
                     ESNYRPLNQKELQIIKNYLEMSR"
     gene            40117..41958
                     /gene="typA"
                     /locus_tag="VVO18_000782"
     CDS             40117..41958
                     /gene="typA"
                     /locus_tag="VVO18_000782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003078415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translational GTPase TypA"
                     /protein_id="HEU5585978.1"
                     /translation="MTKLREDIRNIAIIAHVDHGKTTLVDELLKQSETLDARTELAER
                     AMDSNDIEKERGITILAKNTAVAYNGTRINIMDTPGHADFGGEVERIMKMVDGVVLVV
                     DAYEGTMPQTRFVLKKALEQDLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQ
                     LDFPVVYASAINGTSSLSDDPADQEATMAPIFDTIIDHIPAPVDNSDEPLQFQVSLLD
                     YNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIQEAKAG
                     DLIAVSGMEDIFVGETITPTDAVEALPILHIDEPTLQMTFLVNNSPFAGKEGKWVTSR
                     KVEERLQAELQTDVSLRVDPTDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEV
                     IVKEIDGVKCEPFERVQIDTPEEYQGSVIQSLSERKGEMLDMISTGNGQTRLVFLVPA
                     RGLIGYSTEFLSMTRGYGIMNHTFDQYLPLIPGEIGGRHRGALVSIDAGKATTYSIMS
                     IEERGTIFVNPGTEVYEGMIIGENSRENDLTVNITKAKQMTNVRSATKDQTAVIKTPR
                     ILTLEESLEFLNDDEYMEVTPESIRLRKQILNKAEREKANKKKKSAE"
     gene            41978..42232
                     /locus_tag="VVO18_000783"
     CDS             41978..42232
                     /locus_tag="VVO18_000783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262800.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3165 family protein"
                     /protein_id="HEU5585979.1"
                     /translation="MVYLVLGILLLLLYVFATPESIKGTVNIVAMVCILVALLILLVL
                     SFLKIFQLPTEIFLAIAMLILAYFSVRDITLMPVKKSKRR"
BASE COUNT        13028 a         7888 c         9444 g        12025 t
ORIGIN      
        1 gtatcccagc aatgagcgct ccagtatttg acaatattga agcagctatt aaagaacatg
       61 gattaagcta attctaattt gttaacattc atataacata aaaaagggag gaactgttat
      121 ggatgcaatc tttgacctaa tcggaaaggt tttcaatccc atcttagaaa tgggtggacc
      181 tgtcatcatg ttgatcattt tgacagtatt ggctttactt tttggagtga aattctccaa
      241 agcgcttgaa ggtggtatca aacttgccat cgctcttaca ggtatcggtg ctatcatcgg
      301 tatgctaaat ggtgctttct cagcatcact tgcaaaattc gttgaaaaca ctggtatcca
      361 attgagtatt acagacgttg gttgggcacc actcgcaaca atcacttggg gttctgcttg
      421 gacactatac ttcttgctca tcatgttgat tgtcaacgta gtgatgcttg ctatgaagaa
      481 aaccgataca cttgatgtcg atatctttga tatctggcac ttgtctatca caggtctctt
      541 gattaaatgg tatgctgata acaatggtgt gagtcaaggg gtttcactct ttattgctac
      601 agcagctatc gtccttgtcg gtgtgttgaa aattatcaac tctgacttga tgaaacctac
      661 atttgatgac cttcttaacg ccccaagttc atcaccaatg acatcaactc acatgaacta
      721 catgatgaac ccagttatca tggttttgga taagattttt gaaaaattct tcccaggcct
      781 tgataaatat gactttgatg ctgctaaatt gaacaagaaa atcggtttct ggggatctaa
      841 attcttcatc ggtttcatcc ttggtatcgt tatcggtatt atgggaactc cacatccaat
      901 tgcaggtgtt gcagatgcag ataaatggcg tcttgttatc aaaggatggt tgtctcttgg
      961 tttgactgcc ggtgtatctt tggaactctt ctcacttatc ggttcatggt tcatcgcagc
     1021 cgtagaacca ctatcacaag gtattacaaa cgttgctact aaacgtcttc gaggacgtaa
     1081 attcaatatc ggtcttgact ggccattcat cgctggtcgt gctgaaatct gggcttgtgc
     1141 caacgtactt gcaccaatca tgttgattga agcagtgctt ctttcaaaag ttggaaatgg
     1201 tatcttgcca cttgcaggta tcatcgctat gggtgttact ccagctctct tggttgtaac
     1261 tcgtggtaaa ttgctccgta tgattatctt cggaacactc ttgttgccac tcttccttct
     1321 ttcaggtaca cttattgcac catttgcaac agaacttgct aaaggtgtag gtgccttccc
     1381 agaaggtgtg agccaaactc aattgattac tcactctact cttgaaggac caatcgaaaa
     1441 acttcttggt tggacaattg gtaacactac aactggtgat atcaaagcaa tccttggtgc
     1501 agtagtcttc cttgtattct atatcggtat ctttgcttgg tacagaaaac aaatgatcaa
     1561 acgtaacgaa gagtacgcag caaaagcaaa ataatgcgct cctataaaat ataaactcaa
     1621 tgaaaatcaa agagcaaact aggaaactag ccgcaggttg ctaaaaacac agttttgagg
     1681 ttgtagataa gactgacgaa gtcagctcaa aacatggttt tgaggttgta gatgaaactg
     1741 acgaagtcag ctcaaaacat ggttttgagg ttgtagatga aactgacgaa gtcagtaatc
     1801 atatctacgg caaggcgacg ctgacgaagt ttgaattgga ttttcgcaga gtgtaaattg
     1861 ttgaaactag gttgtcatac catgtatacc acttgggctt tggtagtagc taactgcact
     1921 aaatataata taaggagggt tttatgggga aaggccattg gaatcggaaa agagtttata
     1981 gcattcgtaa gtttgctgtg ggagcttgct cagtaatgat tgggacttgt gcagttctat
     2041 taggaggaaa tatagctgga gaatctgtag tttatgcgga tgaaacactt attactcata
     2101 ctgctgagaa acctaaagag gaaaaaatga tagtagaaga aaaggctgat aaagctttgg
     2161 aaactaaaaa tgtagttgaa aggacagaac aaagtgaacc tagttcaact gaggctattg
     2221 catctgagaa gaaagaagat gaagccgtaa ctccaaaaga ggaaaaagtg tctgctaaac
     2281 cggaagaaaa agctccaagg atagaatcac aagcttcaag tcaagaaaaa ccgctcaagg
     2341 aagatgctaa agctgtaaca aatgaagaaa tgaatcaaat gattgaagac aggaaagtgg
     2401 attttaatca aaattggcac tttaaactca atgcaaattc taaggaagcc attaaacctg
     2461 atgcagacgt atctacgtgg aaaaaattag atttaccgta tgactggagt atctttaaca
     2521 atttcgatca tgaatctcct gcacaaaatg aaggtggaca actcaacggt ggggaagctt
     2581 ggtatcgcaa gactttcaaa ctagatgaaa aagacctcaa gaaaaatgtt cgccttactt
     2641 ttgatggcgt ctacatggat tctcaagttt atgtcaatgg tcagttagtg gggcattatc
     2701 caaatggtta taaccagttc tcatatgata tcaccaaata ccttcacaaa gatggtcgtg
     2761 agaatgtgat tgctgtccat gcagtcaaca aacagccaag tagccgttgg tattcaggaa
     2821 gtggtatcta tcgtgatgtg actttacaag tgacagataa ggtgcatgtt gagaaaaatg
     2881 ggacaactat tttaacacca aaacttgaag aacaacaaca tggcaaggtt gaaactcatg
     2941 tgaccagcaa aatcgtcaat acggacgaca aagaccatga acttgtagcc gaatatcaaa
     3001 tcgttgaacg aggtggtcat gctgtaacag gcttagttcg tacagcgagt cgtaccttaa
     3061 aagcacatga atcaacaagc ctagatgcga ttttagaagt tgaaagacca aaactctgga
     3121 ccgttttaaa tgacaaacct gccttgtacg aattgattac gcgtgtttac cgtgacggtc
     3181 aattggttga tgctaagaag gatttgtttg gttaccgtta ctatcactgg actccaaatg
     3241 aaggtttctc tttgaatggt gaacgtatta aattccatgg agtatccttg caccacgacc
     3301 atggggcgct tggagcagaa gaaaactata aagcagaata tcgccgtctc aaacaaatga
     3361 aggagatggg agttaactct atccgtacaa cccacaaccc tgctagtgag caaaccttgc
     3421 aaatcgcagc agaactaggt ttactcgttc aggaagaggc ctttgatacg tggtatggtg
     3481 gcaagaaacc ttatgactat ggacgtttct ttgaaaaaga tgccactcac ccagaagctc
     3541 gaaaaggtga aaaatggtct gattttgacc tacgtaccat ggtcgaaaga ggcaaaaaca
     3601 accctgctat cttcatgtgg tcaattggta atgaaatagg tgaagctaat ggtgatgccc
     3661 actctttagc aactgttaaa cgtttggtca aggttatcaa ggatgttgat aagactcgct
     3721 atgttaccat gggagcagat aaattccgtt tcggcaatgg tagcggaggg catgagaaaa
     3781 ttgctgatga actcgatgct gttggattta actattctga agataattac aaagccctta
     3841 gagctaagca tccaaaatgg ttgatttacg gttcagaaac atcatcagca acccgtacac
     3901 gaggaagtta ctatcgccct gaacgtgaat tgaaacatag caatggacct gagcgtaatt
     3961 atgaacagtc agattatgga aatgatcgtg tgggttgggg gaaaacagca accgcttcat
     4021 ggacttttga ccgtgacaac gctggctatg ctggacagtt tatctggaca ggtacggact
     4081 atattggtga acctacacca tggcacaacc aaaatcaaac tcctgttaag agctcttact
     4141 ttggtatcgt agatacagcc ggcattccaa aacatgactt ctatctctac caaagccaat
     4201 gggtttctgt taagaagaaa ccgatggtac accttcttcc tcactggaac tgggaaaaca
     4261 aagaattagc atccaaagta gctgactcag aaggtaagat tccagttcgt gcttattcga
     4321 atgcttctag tgtagaattg ttcttgaatg gaaaatctct tggtcttaag actttcaata
     4381 aaaaacaaac cagcgatggg cggacttacc aagaaggtgc aaatgctaat gaactttatc
     4441 ttgaatggaa agttgcctat caaccaggta ccttggaagc aattgctcgt gatgaatctg
     4501 gcaaggaaat tgctcgagat aagattacga ctgctggtaa gccagcggca gttcgtctta
     4561 ttaaggaaga ccatgcgatt gcagcagatg gaaaagactt gacttacatc tactatgaaa
     4621 ttgttgacag ccaggggaat gtggttccaa ctgctaataa tctggttcgc ttccaattgc
     4681 atggccaagg tcaactggtc ggtgtagata acggagaaca agccagccgt gaacgctata
     4741 aggcgcaagc agatggttct tggattcgta aagcatttaa tggtaaaggt gttgccattg
     4801 tcaaatcaac tgaacaagca gggaaattca cccttactgc tcactctgat ctcttgaaat
     4861 ctagtcaagt cactgtcttt actggtaaga aagaaggaca agaaaagact gttttgggga
     4921 cagaggtgcc aaaagtacag accattattg gagaggcacc tgaaatgcct accactgttc
     4981 cgtttctata cagtgatggt agtcgtgcag aacgtcctgt aacctggtct tcagtagatg
     5041 tgagcaagcc tggtattgta acggtgaaag gtatggctga cggacgagaa gtagaagctc
     5101 gtgtagaagt gattgctctt aaatcagagc taccagttgt gaaacgtatt gctccaaata
     5161 ctgacttgaa ttctgtagac aaatctgttt cctatgtttt gactgatgga agtgtacaag
     5221 agtacgaagt agatagctgg gagattacgg aagtagataa agccaaactt tcagtagctg
     5281 gatcacgtat tcaaatgact ggtcagttag ctggagaaac tattcatgca acccttgtgg
     5341 tagaagaagg aaatgctgca gcacctgtag tgccaactgt tactgttgga ggtgaagcag
     5401 taacaggtct tactagtcga caaccaatgc aatatcgtac tctatcttat ggtgcccaat
     5461 tgccagaagt cacagcaagt gctgaaaatg ctgatgtgac agttcttcaa gcaagcgcag
     5521 caaacggcat gcgtgcaagc atatttgttc agcctaaaga tggtggccct cttcaaacct
     5581 atgcaattca attactagaa gaagcaccaa aaattgctca cttgagcttg caagtggaaa
     5641 aagctgacag tctcaaagaa gaccaaactg tcaaattgtc ggttcgagct cactatcaag
     5701 atggaacgca agctgtatta ccagctgata aagtaacctt ctctacaagt ggtgaagggg
     5761 aagtcgcaat tcgtaaagga atgcttgagt tgcataagcc aggagcagtc actctcaaag
     5821 cggaatatga gggagctaaa ggccaagttg aactcactat ccaagccaat actgagaaga
     5881 agattgcgca atctatccgt cctgtaaatg tagtcacaga tttgcatcaa aaacctactc
     5941 ttccaacaac agtaacggtt gagtatgaca aaggtttccc taaagctcac aaagtcactt
     6001 ggcaagctat tccgaaagaa aaactagact cctatcaaac atttgaagta ctaggtaaag
     6061 ttgaaggaat tgaccttgaa gcgcgtgcaa aagtctctgt agaaggtatc gtttcagttg
     6121 aagaagtcag tgtgacaact ccaatcgcag aagcaccaca attaccagaa agtgttcgga
     6181 catatgattc aaatggtcac gtttcatcag ctaaggttgc atgggatgcg attcgtccag
     6241 agcaatacgc taaggaaggt gtctttacag ttaatggtcg cttagaaggt actcaattaa
     6301 caactaaact tcatgttcgc gtatctgctc aaactgagca aggtgcaaac atttctgacc
     6361 aatggaccgg ttcagaattg ccacttgcct ttgcttcaga ctcaaatcca agcgacccag
     6421 tttcaaatgt taatgacaag ctcatttcct acaataacca accagccaat cgttggacaa
     6481 actggaatcg tactaatcca gaagcttcag tcggtgtcct attcggagat tcaggtattt
     6541 tgagcaaacg ttcagttgat aacttaagcg ttggcttcca tgaagaccat ggagttggtg
     6601 caccgaagtc ttatgtgatt gagtattatg ttggtaagac tgtcccaaca gctcctaaaa
     6661 accctagttt tgttggtaat gaggaccatg tctttaatga ttctgccaac tggaaaccag
     6721 ttactaatct aaaagcccct gctcaactca aggctggaga aatgaaccac tttagctttg
     6781 ataaagttga aacctatgct gttcgtattc gcatggtgag agcagacaac aaactaggaa
     6841 cgtctatcac agaggtacaa atctttgcga aacaagttgc ggcagccaag caaggacaaa
     6901 caagaatcca agttgacggt aaagacttag caaacttcaa ccctgatttg acagactact
     6961 accttgagtc tgtagatgga aaagttacgg cagtcacagc aagtgttagc aacaatggcc
     7021 tcgctaccgt cgttccaagc gttcgtgaag gtgagccggt tcgtgtcatc gcgaaagctg
     7081 aaaatggcga catcttagga gaataccgtc tgcacttcac taaggataag aacttacttt
     7141 ctcataaacc agttgctgcg gttaaacaag ctcgcttgct acaagtaggt caagcacttg
     7201 aattgccgac taaggttcca gtttacttca caggtaaaga cggctacgaa acaaaaaacc
     7261 tgacagttga atgggaagaa gttccagcgg aaaatctgat aaaagcaggt caatttaccg
     7321 ttcgaggcca tgtccttggt agtaaccttg ttgctgagat cactgtacga gtgacagaca
     7381 aacttggtga gactctttca gataacccta actatgatga aaacagtaac caggcctttg
     7441 cttcagcaac caatgatatt gacaaaaact ctcatgaccg cgttgactat ctcaatgacg
     7501 gagatcattc agaaaatcgt cgttggacaa actggtcacc aacaccatct tctaatccag
     7561 aagtatcagc gggtgtgatt ttccgtgaaa atggtaagat tgtagaacgg actgttgcac
     7621 aaggaaaagt tcagttcttt gcagatagtg gtacggatgc accatctaaa ctcgttttag
     7681 aacgctatgt cggtccagag tttgaagtgc caacctacta ttcaaactac caagcctacg
     7741 acgcagacca tccattcaac aatccagaaa attgggaagc tgttccttat cgtgcggata
     7801 aagacattgc agctggtgat gaaatcaacg taacatttaa agatatcaaa gccaaagcta
     7861 tgagatggcg tatggagcgt aaagcagata agagcggtgt tgcgatgatt gagatgacct
     7921 tccttgcacc aagtgaattg cctcaagaaa gcactcaatc aaagattctt gtagatggaa
     7981 aagaacttgc tgatttcgct gaaaatcgtc aagactatca aattacctat aaaggtcaac
     8041 ggccaaaagt ctcagttgaa gaaaacaatc aagtagcttc aactgtggta gatagtggag
     8101 aagatagcct tccagtactt gttcgcctcg tttcagaaag tggaaaacaa gtcaaggaat
     8161 accgtatcca cttgactaag gaaaaaccag tttctgataa gacagttgct gctgtacaag
     8221 aagatcttcc aaaactcgaa tttgttgaaa aagatttggc atacaagaca gttgagaaaa
     8281 aagattcaac actgtatcta ggtgaaactc gtgtagaaca agaaggaaaa gttggaaaag
     8341 aacgtatctt tacagcgatt aatcctgatg gaagtaagga agaaaaactc cgtgaagtgg
     8401 tagaagttcc gacagaccgc atcgtcttgg ttggaaccaa accagtagct caagaagcta
     8461 aaaaaccaca agtgtcagaa aaagcagata caaaaccaat tgattcaagt gaagctagtc
     8521 aaactaataa agcccagtta ccaaatacag gtagtgcggc aggccaagca gcagtagcag
     8581 caggtttagc tcttctaggt ttgagtgcag gattagtagt tactaaaggt aaaaaagaag
     8641 actagaaatt ttgatacctt ctttatcatt aaagaccaaa gaaaaactct tgtcctaaat
     8701 agaagataaa gagcctgaga caaaatagtt ctcaaccaca aaaaagctag agattcctaa
     8761 ttgcggaact ctagcttttt aattttgagt cgttctctta ttgtatagta gattgaaagt
     8821 agaatagtac acttctactt ctaaaacatt gttagaaatc gatttgactg tccttatcga
     8881 tttgtcctgt tcttatttca ttttactata ttttaggagg ttattggcca taagtaccaa
     8941 tcccatgtca attctcactt gcccctcaga ttacatctct tgtaacccaa agaagccttt
     9001 atctgcccaa agacaggttc cacatcaatc ttgcgttgag cgaaaatctg tctaccttgg
     9061 ggagataaaa gcgcctgaca ttctttagct ttcaagtttt gatagcgttc gttcatatat
     9121 agtccctttt gaggggctga ttcaggttcg tcggcgtagt aaaccttgat ttcctgttga
     9181 aagtctgtct gtgttttctg atgtttggta tggtgaaaac gataatacca gccatcagga
     9241 tgtgtgtagc tatcctcctt gtcattatag tgccaattcg ctaagttttt agctgactct
     9301 ttataccctc tcttttgttc cttatcaaac atggcatatt taatcaggag gggagtgatt
     9361 tcttcttgaa aatagacttg tatctgttct tgaagtttgg cggagaattt ctctgtcgtt
     9421 ttcttccaca caaaactata cttgttggca ttggcttcaa tcttagttcc gtcaataaac
     9481 aaacaatcta aggtcactaa ctcttccatt tttcaatttt tcgaccagag aaaatccctt
     9541 gtgaataggc aaatagaaga gtagatacaa gcattttaag gtgataagac aggcgatcaa
     9601 aggcatgata gaaggcgtgg aaatgacaat cctccaaggt attcaccact ttttcaatag
     9661 taaagacgag atggtcttgt ggcaagaagg aactgatttc tagtggtaaa gttgtttgat
     9721 ttgtgttata gtgaatatgc atgggatagc ctttctaaat ggtttattgt gcaattctat
     9781 tttaccaaga ctatcgcaac catgcaaaaa agcaacggca aatccgttgc cttttttgga
     9841 tataagagac tattgtccca gactcttttc tttgtataaa attgtatagt gttattgtct
     9901 atactatttt gtagagaaag caaaaatccc tagaaaatgc ttagggattc gactatttca
     9961 ttaagaacaa ttcaacaatc atctctatat acatgataag ggttaataag aatcctgcac
    10021 gccagaagaa tttgatgaat ttaggatagt aaaagctgcg ttttttcaaa aggaagaaaa
    10081 agacgagaat aatggctagg attgagaggg ctagccccag tctagggagg aaattatggg
    10141 taaaggtttt agttgtaatc aagtaatact caaataccaa gactggaaaa gccaaatccg
    10201 caaagtttcg tcctagtttt tttaatctaa aaagtttggt taggataatg cagacgacta
    10261 aggtcagtat caataataaa atagatgcta atttcattaa aatcataccc atattgtatc
    10321 ataaaaaaag gctaatggaa acgagaaaca gaggaattta taggaaagtc aggcttttga
    10381 gattgtgggt gatttttgtt ataatgaaag ttataaaatc ttatgatacc ttgaatgatt
    10441 attatcgaaa actctttgga gaaaagactt ttaaagtccc tattgatgcg ggatttgact
    10501 gtcccaatcg tgatggaact gtggctcatg gaggctgtac tttttgtacg gtttccggtt
    10561 ctggagatgc cattgtagcc ccagatccgc ctatccgtga gcaattttat aaggaaattg
    10621 actttattca tcgtaagtgg ccagatgttc agaagtatct ggtttatttt caaaatttta
    10681 ccaacaccca tgaaaaggtg gaagttattc gagagcgtta tgaacaggct atcaatgagc
    10741 caggtgtggt aggaatcaat attggaacgc gcccagactg tttaccagac gaaaccatcg
    10801 aatatttggc tgagttatcg gagtgcatgc atgtgacggt tgaattgggc ttgcagacta
    10861 cttatgaagc aacctctgac ctgattaacc gtgcgcattc ttatgaattg taggtggaaa
    10921 cggtcaagcg tttgagaaag tatccaaaaa ttgagattgt ttcccatttg atcaatggtt
    10981 tgcctggtga aacccatgag atgatggttg aaaatgtccg ccgttgtgtc acggataacg
    11041 atattcaagg gattaaactg catttgctcc atcttatgac aaatactcgt atgcaacgag
    11101 attaccatga gggacgttta caattgatga gtcaggacga atatgtcagg gtcatctgtg
    11161 accaactgga aattattccc aaacatatcg tcatccatcg aattacagga gatgcgccta
    11221 gggatatgct gattggtcct atgtggagcc tcaataaatg ggaagtcctc aacagcattg
    11281 agatggagat gagacgtcgt ggaagtgttc aaggatgcaa ggctgtaaaa caggagtttg
    11341 aaaatgaaaa gaccacttga gatggcacat gattttttgg ctgaggtcgt gacaaaagag
    11401 gatgtcgtag tggatgcgac tatgggaaat ggtcatgaca cgcttttttt agccaagcta
    11461 gccaagcaag tctatgcctt tgatattcag aagcaagcct tggaaaagac ccaagagcgt
    11521 ttgcatcagg ctggcttgac aaatgcccag ttaatcttgc aaggccatga gacactggac
    11581 cagtttgtga caaaagctaa ggcagggatt tttaatttgg gctatttgcc gtcagctgat
    11641 aagtctgtca tcacccgacc gcagacaacg attgaggcat tagaaaagct atgtggctta
    11701 cttgtcaaag gtggacgaat tgctattatg atttactatg gtcatgaagg aggcgacctc
    11761 gagagagatg ctgtcttgga ttttgtgatc cagttgaacc aacaagagta cacagctgcc
    11821 atttaccgaa ctttaaacca agtcaacaac ccgccgtttt tagtgatgat tgaaaaatta
    11881 gagagataca gacatggata aacaatacct acacgaaaag ctggatgcca tgcgccagaa
    11941 ttttgttgaa tcaacctacc acgaacgagc ggtgggcgtg ctagaccaag cgcatatgag
    12001 caaaaaaatg cttaaaatca agaaaaaatt agttgctctt gaaatggaac ggtgccagag
    12061 aaaaattgag cacaaagact gttccaagat tgaccaaaaa atcaaagagc agaaggagat
    12121 atttgaatcc tgttgtaaaa aagattaagg aggacgtgcg tggaattact gatttacctc
    12181 atcctatttt tactggtctt gattgtctca agtacaacca ataagctcct accctttttg
    12241 cctctccctt tggtgcagat tcttttggga attgtgattg gtctcttttt acccaatact
    12301 gactttcacc ttaatacgga gttgtttttg gcactggtta tcggcccctt gcttttccga
    12361 gaggctgaag aagcagatgt tacggctatt ttaaaacact ggcgaatcat tgtttatctc
    12421 atatttccag tgatttttat ctcgaccctg agtttgggtg gcttggccca tcttctttgg
    12481 ttcagccttc ccttggcagc ttgcttggct gttggggcag cccttggtcc tacggacttg
    12541 gtggcctttg cctctctttc ggagcgtttt agctttccta agcgcgtgtc caatattctt
    12601 aagggcgaag gactcttgaa tgatgcttct ggtttggtgg cttttcaggt agctttgaca
    12661 gcttggacaa ctggagcttt ttctctgggg caagctagca gttcactcat cttttcaatc
    12721 ctaggcggtt ttttaattgg atttttaaca gccatgacca accgcttcct ccataccttc
    12781 ttgctaagtg tgcgtgcaac ggatattgcc agtgaacttt tattagaatt gagtttgcct
    12841 cttgtgacct tctttctggc agaagaagtt catgtttcag gtattattgc cgtcgtagtt
    12901 gctggaattt taaaggcaag tcgtttcaag aaaatcacgc tcctcgaagc ccaagtggat
    12961 acggtgaccg agacggtctg gcatacagtg acctttatgc tcaacggttc tgtctttgtg
    13021 attttaggga tggagctgga aatgatagca gaacctatct tgaccaatcc aatctataat
    13081 cctctacttt tattgctatc tcttatcgcc cttacctttg tcctctttgt cattcgtttt
    13141 attatgatct atggctatta tgcctataga acccgacgcc tcaagaaaaa gctaaataag
    13201 tatatgaagg acatgtttct cttgaccttt tcaggtgtta agggaacggt gtcgattgct
    13261 acgattctct tgataccaag taatctagaa caggagtatc ctctcttgct tttccttgtt
    13321 gcaggtgtga cgcttgttag ctttttaaca ggtctcttgg tcttgcctca tctttctgat
    13381 gaagaggaag aaagcaagga ttatctcatg catatcgcca ttttgaatga agtaacgcta
    13441 gagttggaaa aagagttgga agacaccaga aataaacttt ccctctatgc ggctattgac
    13501 aattatcatg gacgtattga aaatctcatt ttaagccaag aaaaccagga tgatcaagaa
    13561 gactgggctg ctttgaaact cttgattctt agtattgaaa gtgatggttt ggaacaggcc
    13621 tatgaagagg ggaacattag caatcgtgct taccgagttt accaacgtta tctgaaaaat
    13681 atagaacaag gaatcaatcg taaacttgcc tcaagactga cctattattt tcttgtttcc
    13741 ttgaggattt tacgttttct ccttcatgaa gtttttactc tcggaaagac cttccgtagc
    13801 tggaagaaca aggagcaaag ccgtctccgt gctcttgatt atgaccaaat tgcagagctc
    13861 tatcttgcca atacagagat gattattgaa agtttggaaa acctgaaggg agtctacaga
    13921 cgctctttga ttagttttat gcaggagtct cgtcttcgag aaacagctat tatcagcagt
    13981 ggtgcctttg tcgaacgggt tatcaatcgt gtcaaaccca acaatatcga tgaaatgctg
    14041 agaggctatt atctggagcg caagttgatt ttcgaatacg aagaaaaacg attaattaca
    14101 actaagtatg ccaagaaatt acgacaaaat gtaaataact tagagaacta ttccttgaag
    14161 gaagctgcca ataccctgcc gtatgatatg gtggaattgg taagaagaaa ttagttaata
    14221 ctcttcgaaa atctcttcaa accacgtcag cgtcgccttg gattatatat gtgactgact
    14281 tcgtcagttt catctacaac ctcaaagcag ggctttgagc aacctgcggc tagcttccta
    14341 gtttgctctt tgattttcat tgagtataag attataaatg aaggagtatg acatgaaaaa
    14401 gtggtggaaa gagctgatag acaagccttt attaaaagct tttttgcatt attatcaagc
    14461 atcagatagt gagttgacca gtgtcgcagt agcctactat tggttgattt cgattttccc
    14521 cctgcttttg gtggtggtca atatcctccc ctattttcag attcctgtgg gagaatttct
    14581 gtgctttatg aaagacgttc tgcccccaag cctctatgaa ggtgtggaaa aaatagccag
    14641 agaagttttg acgcaacctt caacaggttt attgagtttt tctgttttat cggcgttatg
    14701 gagtttttca aaatctatga atttcttgca aaaagctttt aacaaggctt atggcgtcga
    14761 aaagagtcgt ggacttattt cccatcagat gctaagtctc ctagtcagtt ttggcttgca
    14821 gctcctcttt gcgtttgcct tgtttttgat cttatttggt cagatgattt tggctttact
    14881 tgctcattat tggacaaaag atggcattat ctatcaggct ttacaagggt tggcaggtcc
    14941 tctgatttac gccctcctct ttgctatctt ggtcatgctt tattattttc ttcccaatat
    15001 atctaacagg aaaattagct ataccctacc aggcagtgcc tttgttctct tagtgatttt
    15061 aggtttacta actctgttct ctagttatct caattactat gtccatcatt tggtggatgt
    15121 ccgaatttta ggttccgttc ttcttgttgt tatgatgttt tggtttatct tgattgctaa
    15181 aattgttatc ctaggcgcgg ttatcaatgc cagtatgcag agtttgagag atccggtctt
    15241 taaaaaagac taactattta tccattacaa aagcgcatag tatcaaaact ttatagaacc
    15301 ttgatactat gcgcttttgt gctttgacag ttttttgtat agtttttgtc caagatttct
    15361 aaatcatctg attaaattcc tattttcccc tatcattgtc cctgtttttt cgaaaatgga
    15421 aggagtataa taaatctatc aataaaatga taggaggaac tttatgggtc atattttctt
    15481 ttttctaagt gtctttttgg cagggattct atccttcttt tctccttgta tcttaccttt
    15541 gttaccggtc tatacaggag tgttactaga tgataaggat ggtgctcagg cttctagcgg
    15601 caaattttca atctcagtta ctagtttatt acgaactctg gcctttatag caggaatttc
    15661 ctttatattt attttgttgg gctatggagc tggtttttta ggcgatttgc tttatgcttc
    15721 ttggttccaa tatcttactg gggcaattat tatccttctt ggtttgcacc aaatggagat
    15781 tctacacttt aaggggcttt ataaggaaaa gaggctacaa ctgcaaggac aggggcaaaa
    15841 tggtaagggc tatagtcagg catttttatt gggcttgacc tttagttttg cttggacgcc
    15901 ttgcgtgggg ccggttctgg ggtctgtttt ggccttggcg gcttcaggtg gttcaggagc
    15961 ttggcaggga gctggtctca tgttggtgta tacgctgggc ttggcgctac cattcttgct
    16021 tctagctctg acctctagtt atgttttgaa acatttccga aaacttcatc cctatctcgg
    16081 aatcctcaaa aaagtgggtg gttttctcat tattgtgatg ggactcttgg ttctgtttgg
    16141 aaatgcttca attttaagtc aattatttga ataaaatgga aaggaatatc aatatgaaaa
    16201 aatggcaaac atgtgttctt ggagcaggtt cgctcctttg tttgacggct tgttcaggca
    16261 agtccgtgac tagtgaacac caaacgaaag atgaaatgaa gacggagcag acagctagta
    16321 aaacaagcgc agctaaaggg aaagaggtgg ctgattttga attgatggga gtagatggca
    16381 agacctaccg tttatctgat tacaagggca agaaagtcta tctcaaattc tgggcttctt
    16441 ggtgttccat ctgtctggct agtcttccag atacggatga gattgctaaa gaagctggtg
    16501 atgactatgt ggtcttgaca gtagtgtcac caggacataa gggagagcaa tctgaagcgg
    16561 actttaagaa ttggtataag ggattggatt ataaaaatct cccagtccta gttgacccat
    16621 caggcaaact tttggaaact tatggtgtcc gttcttaccc aacccaagcc tttatagaca
    16681 aagaaggcaa gctggtcaaa acacatccag gattcatgga aaaagatgca attttgcaaa
    16741 ctttgaagga attagcctag gaggtgtctt atgaatgata agttaaaaat cttcttgttg
    16801 ctaggagtat tttttctagc cataaccggt ttctatgttc tattgatacg aaatgcaggg
    16861 cagacagatg cctcgcaaat tgaaaaggcg gcagttagcc aaggaggaaa agcagtgaaa
    16921 aaaacagaaa ttagtgaaga cgcagacttg cacgaaattt atctagctgg aggttgtttc
    16981 tggggagtgg aggaatattt ctcacgcgtt cccggggtga cggatgccgt ttcaggctat
    17041 gcaaatggta gaggagaaac aaccaagtac gaattaatta accaaacagg tcatgcagaa
    17101 accgtccatg tcacctatga tgccaagcaa atttctctca aggaaatcct gcttcactat
    17161 ttccgcatta tcaatccaac cagcaaaaat aaacaaggaa atgatgtggg gacccagtac
    17221 cgtactggtg tttattacac agatgacaag gatttggaag tgattaacca agtctttgat
    17281 gaggtggcta agaaatacga tcaacctcta gcagttgaaa aggaaaactt gaagaatttt
    17341 gtggtggctg aggattacca tcaagactat ctcaagaaaa atccaaatgg ctactgccat
    17401 atcaatgtta atcaggcggc ctatcctgtc attgatgcca gcaaatatcc aaaaccaagt
    17461 gatgaggaat tgaaaaagac cctgtcacct gaggagtatg cagttaccca ggaaaatcaa
    17521 acagaacgag ctttctcaaa ccgttactgg gataaatttg aatccggtat ctatgtggat
    17581 atagcaactg gggaacctct cttttcatca aaagacaaat ttgagtctgg ttgtggctgg
    17641 cctagtttta cccaacccat cagtccagat gttgtcacct acaaggaaga taagtcctac
    17701 aatatgacgc gtatggaagt gcggagccga gtaggagatt ctcaccttgg gcatgttttt
    17761 acggatggtc cacaggacaa gggcggctta cgttactgta tcaatagcct ctctatccgc
    17821 tttattccca aagaccaaat ggaagaaaaa ggctacgctt atttactaga ttatgttgat
    17881 taatactctt cgaaaatctc ttcaaaccac gtcagcgtcg ccttaccgta tgtagggtta
    17941 ctgacttcgt cagttttatc tacaacctca aagctatact ttgagaaacc tgtggctatc
    18001 ttcctagttt actttttgat tttcattgag tataagaggt ctttcctaag cagttagagg
    18061 agaattttgc tatactgata ctagtaagtg gtaaaggagc agatcatgac ctacacaatc
    18121 ttaatcgtag aagatgaata tctggtaaga caaggtttga ctaaactggt caatgtagca
    18181 gcctacgata tggaaatcat cggtcaggct gaaaatggaa ggcaggcttg ggaattgatc
    18241 caaaagcagg tgccagatat cattttaact gatatcaaca tgcctcatct aaatggcatc
    18301 cagttggcca gtctggtacg agaaacctat cctcaggttc atttggtctt tttaacaggt
    18361 tacgatgatt ttgattatgc cttgtctgct gtcaaactag gtgtggacga ctacctgctc
    18421 aaaccctttt ctcgtcagga tattgaggaa atgttgggga aaatcaaaca aaaactagac
    18481 aaggaagaga aagaagagca gttacaagat ttattgacta ataggtttga aggaaacatg
    18541 gcccagaaaa tccagtctca tctggctgat agccaattta gtttaaagtc tttagccagt
    18601 gacttaggtt ttagtccgac ctatctaagt tccttgatta agaaagagtt gggcttgcct
    18661 tttcaggatt atctggtgag agaacgtgtt aaacaagcca agctcttgct tttaactaca
    18721 gatctgaaga tttatgagat cgcagagaag gttggttttg aagatatgaa ctattttacc
    18781 caacgtttta agcagattgc aggtgtgaca cctcgtcagt ttaagaaggg agaaggccga
    18841 tgaagcgttc ttctctttta gttagaatgg ttatttccat ctttctggtc tttctcattc
    18901 tcctagctct ggttggaact ttctactatc aatcaagttc ttcagccatt gaggccacca
    18961 ttgagggcaa cagccaaacg accatcagcc agactagcca ctttattcag tcttatatca
    19021 aaaaactaga aaccacctcg actggtttga cccagcagac ggatgttctg gcctatgctg
    19081 agaatcccag tcaagacaag gtcgagggaa tccgagattt gtttttgacc atcttgaagt
    19141 cagataagga cttgaaaact gttgtgctgg tgaccaaatc tggtcaggtc atttctacag
    19201 atgacagtgt gcagatgaaa acttcctctg atatgatggc tgaggattgg taccaaaagg
    19261 ccattcatca gggagctatg cctgttttga ctccagctcg taaatcagat agtcagtggg
    19321 tcatttctgt cactcaagaa cttgttgatg caaagggagc caatcttggt gtgcttcgtt
    19381 tggatatttc ttatgaaact ctggaagcct atctcaatca actccagttg gggcagcagg
    19441 gctttgcctt cattatcaat gaaaaccatg aatttgtcta ccatcctcaa cacacagttt
    19501 atagttcgtc tagcaaaatg gaggctatga aaccctacat cgagacaggt cagggttata
    19561 ctcctggtca caaatcctac gtcagtcaag agaagattgc aggaactgat tggacggtac
    19621 ttggcgtgtc atcattggaa aagttagacc aggttcggag tcagctcttg tggaccttgc
    19681 ttggggccag tgtcacatct cttcttgttt gtctctgctt agtgtggttc agtcttaaac
    19741 gctggattgc tcctttgaag gatttgagag aaaccatgtt ggaaattgct tctggtgctc
    19801 aaaatcttcg tgccaaggaa gttggtgcct atgaactgag agaagtaact cgccaattta
    19861 atgccatgtt ggatcagatt gatcagttga tggtagctat tcgtagccag gaagaaacga
    19921 cccgtcagta ccaacttcaa gccctttcga gccagattaa tccacatttc ctctataaca
    19981 ctttggacac catcatctgg atggctgaat ttcatgatag tcagcgagtg gtgcaggtga
    20041 ccaagtcctt ggcaacctat ttccgcttgg cgctcaatca aggcaaggac ttgatttgtc
    20101 tctctgacga aatcaatcat gtccgccagt atctctttat ccagaaacaa cgctatggag
    20161 ataagctgga atacgaaatt aatgaaaatg ttgcctttga taatttagtc ttacccaagc
    20221 tggtcctaca accccttgta gaaaatgctc tttaccatgg cattaaggaa aaggaaggtc
    20281 agggccatat taaactttct gtccagaaac aggattcggg attggtcatc cgtattgagg
    20341 atgatggcgt tggcttccaa gatgctggtg atagtagtca aagtcaactc aaacgtgggg
    20401 gagttggtct tcaaaatgtc gatcaacggc tcaaacttca ttttggagcc aattaccaga
    20461 tgaagattga ttctagaccc caaaaaggaa cgaaagttga aatatatata aatagaatag
    20521 aaactagcta actcccagtc aattctggga gttttatgcg taattgggca aactttctag
    20581 gttgtctatc ttgctaaaaa caagaaaaaa cggtatgata gaagagtgac aacagaggta
    20641 acagagatga acgagacaca gattcaaaga gaaacacgtc aggtagtgga agatgtttta
    20701 gaaaagacca atttgaagca gggggccctt tttgttttag gtctatcttc tagtgaggtg
    20761 ctaggtggtc agattgggaa agaatccagt caagagattg gtgagctgat agtggagact
    20821 atcttgggta ttctaggtag tagaggtatc catttagcag ttcaaggttg tgagcatgtc
    20881 aatcgggctc tcgttgttga acgtcaggtg gcagagcagt ttggtctgga aattgtcagt
    20941 gtccatccta ctcttcatgc aggaggttcg gggcagttgg cagcctttaa gtttatgcag
    21001 gatccagttg aggttgaatt tatcaaggct catgctggat tggatatcgg agacactgca
    21061 attggcatgc atgtcaagca tgttcaggtt ccgattcgcc ctattttgag agagattggc
    21121 catgcccatg taacggcact ggctagtcgt ccaaaattaa tcggaggtgc gcgtgcgcac
    21181 tatccgcaag atgctattag gaagtcttga gaatgaataa aggagataaa agtgtttaaa
    21241 aaagaccgtt tttcaattcg taagattaag ggagttgtag gctctgtatt tcttggaagc
    21301 cttttgatgg ctccttctgt agtggacgca gccacctatc actatgtaaa taaagagatt
    21361 atttcacaag aagctaaaga tttaattcag acaggaaagc ctgacaggaa tgaagttgta
    21421 tatggtttgg tgtatcaaaa agatcagttg cctcaaacag ggacagaagc atctgttttg
    21481 acagcttttg gtttgctgac tgttgggagc ttgcttttaa tctacaagag aaagaaaatt
    21541 gctagcgtct ttctagttgg agctatggga ttggtagttc ttcctagtgc aggggctgta
    21601 gacccagttg cgaccctagc actggctagt cgagagggtg ttgttgaaat ggagggctat
    21661 cgctatgttg gttatctatc aggtgacatc ctcaaaacgc ttggcttgga cactgtttta
    21721 gaagaaacct cagcaaaacc tggagaggtg actgtagtcg aagttgagac tcctcaatca
    21781 acaacaaatc aggagcaagc taggacagaa aaccaagtag tagaggcaga ggaagctcca
    21841 aaagaagaag cacctaaaac agaagaaagt ccaaaggaag aaccaaaatc ggaggtaaaa
    21901 cctactgacg acacccttcc taaagtagaa gaggggaaag aagattcagc agaaccagct
    21961 ccagttgaag aagtaggtgg agaagttgag tcaaaaccag aggaaaaagt agcagttaag
    22021 ccagaaagtc aaccatcaga caaaccagct gaggaatcaa aagttgaacc accagtagaa
    22081 caagcaaaag gcccagaaca acccgtgcaa cctacacaag ctgagcaacc aaggatacca
    22141 aaagattcat cacaaccaga agatcctaaa gaagataggg gagcggaaga gacaccgaaa
    22201 caagaagatg aacagccagc agaagcccca gaaatcaagg ttgaagaacc agtagaatca
    22261 aaagaggaga ctaaaacagc taaggggacg caagaagaag gcaaagaagg tcaagcacca
    22321 gtacaagaag taaacccaga atataaagta acaacaggta cagttgagaa gtctaccgaa
    22381 agtgaattag atttcacaac agaagtagtt ccggatgaca caaaatatgt agatgaagaa
    22441 gttgttgaac gtcaagggtc taaaggagtt caagttacga aaacaactta cgaaacagtg
    22501 gaagttgtag agacagacaa agtcctttct acaactacag aagtgaaaac tcctgctgtt
    22561 cctaaagtcg ttaaaaaagg aacaaaacca gttaaaggaa cagcagtcga aacaagagaa
    22621 gaagtcattc cttttgctac gaaagaacaa gaagatgaca ctttaaaacg cggaacaaga
    22681 caagtagctc aagaaggtgt aaatggtaag aaacaaatta ctgaaaccta taaaacaatt
    22741 cgcggagaaa aaacaaacga agctccaaca gtagaagaaa cagttctcca agcacctcaa
    22801 gatgagatta tcaaaaaagg cacaaaaggt ttagaaaaac caaccttaga atgggttaaa
    22861 acagataaag atgtcttgaa gaagagtgcg acagccagtt atacattgaa taaaccagat
    22921 ggggtagaaa tcaaatccat caaagtagct ctaaaagata atactggaac agttattaaa
    22981 gaagtaacgg tagaagaaaa taacttaaac gctactttag acaacttgaa atattatcaa
    23041 ggttatacac tatccacaac catggtctat aatcgaggcg aaggcgaaga aactgaaacg
    23101 ttagaagata aagaagttca gttagacctt aaaaaagttg aaatcaaaaa catcaaagaa
    23161 actagcttga tgagtgtgga tgatgctggt gttgaaacag ataagagctt acttactgaa
    23221 aaaccgacag acgttgctcc actttaccta cgagtgacaa ctcatgataa caaaacaaca
    23281 agactggcag taagttcagt tgaagaagtt gttgttgatg gaaaaacatt gtacaaagtg
    23341 gtagctaaag ctcctgactt agttcaacgt agagaagatg atacactaag cgaagagtat
    23401 gtacattact ttgaaaaaca attaccaaaa gtagataatg tgtactatag ctttaacgag
    23461 ttaattacag atatgcaaaa aaatcctact ggtacattca aactaggtgc agatcttaat
    23521 gcagcgaata ctccaactcc aagtaaatca tatgtaacag gtgaatttaa aggtaaatta
    23581 tcaagtgttg atggtcaaca ttatacgatt cacaatactg cgcgcccatt atttaacaat
    23641 attgttggtg gtaccgttaa aaatattaat cttaacaatg taaatatcga tatgccttgg
    23701 gctgatcaaa ttgcatctgt agcaaatgtg atcaaaggtg gtagccttat tgagaatgtt
    23761 aaagtcaaag gtaatgtgct cggcagaaac tgggtatctg gtttcattga taaaattgac
    23821 agtggtggta gattagttaa tgttgcattt attggtaatg taacttctgt tggagatggg
    23881 gataaattct taacaggtat tgttggagaa aactggaaag gatatgtcga aaaagcatac
    23941 gttgaagcta atattaaagg taagcgagct aaagctgctg gtatatctta ttggtcgcaa
    24001 aatagcggag ataataatgc tgtcggtaga gatggagcaa ttaagaaatc tgtcgttaaa
    24061 ggttcaatag atgtagaaaa accaattgaa gttggtggcg ctgttggaag tttaaattat
    24121 cttggttata tagaagacac tgttgctatg atgaaagtta agaacggtga aattttctac
    24181 ggttcgcatg atatcgatac cgatccatat tacacaggag aacgagtaaa tagaaatttc
    24241 attgttgacg gtgtaagtga aggtaaatct tcgtatacat actctaaaca acaaaagcgt
    24301 attaaatcaa tatctcaaga ggaagcagat aagaaaatta aagaattggg tatcacagca
    24361 gataaattta caattatcga tccaattgta aataaactta acaacatcaa acaaaaagct
    24421 gatacttata aagatactca agattacaaa gcagaccgtg aacttactta tcgtaatatc
    24481 gaaaaacttc aaccattcta caataaagag tggattgtag accaaggtaa taaagttcca
    24541 tcaaattcta aattattaac tacagaagta ttatctgtta caggtataaa gagcggtcaa
    24601 ttcgtaactg atttgtcaga tattgataaa attatgattc actattctga tggagcaaag
    24661 gaagaattga atgttactcg tcaagaatca aacgttcaac aagtgcgtga gtacagtatc
    24721 acagatttag atatactcta tacaccaaat atggttgaga aagatcgcgc tcagttgatg
    24781 actgatgtaa agtctaagct atctagtgta gaattagagt ctgatggagt gcgtcaactt
    24841 ctcgttaaga gagatactaa gaaagatgcg aatgcaaata gtgtaggtcg tcaaaatgga
    24901 tacattagag atttattcct tgaagaaagt ttctctgaag ttaaagcaaa tcttgacaaa
    24961 ttggtaaaac agatacttga aaatgaagat catcaactca acgataacga attagctgaa
    25021 cgtgctttac tgaagaaagt tgaagataat aaagctaaaa tcatgatggg actggcatac
    25081 ttaaatcaat attatgcttt taaatacgat gagttatcaa ttaaagatat tatgatgttt
    25141 aaacctgatt tttatggtaa gacagcaagt gttattgata gattgattaa tattggttct
    25201 gcagaaaata atctaaaagg agatagaacg caagatgctt atcgtggtat aatttcaggg
    25261 gcaacaggta aaggtagttt acatgacttc ttgacctaca atatgaaatt attcacaaat
    25321 gaaacagaca taaatgtttg gtttaagaaa gctattgaaa agaatgctta tgtagttgaa
    25381 caaccatcaa cgaaccctgc atttgccaac aaaaaatatc gtctatacga aggaattaat
    25441 aatgggcaac atgggcgcat gattttacct cttcttaact tgaaaaatgc acatctattt
    25501 atgatttcaa catacaacac tatctcgttt agttcatttg aaaaatatgg caaagacaca
    25561 gatgaaaaac gtgaaaagtt caagagtgag atcaataaac gtgctaaaga gcaggttaat
    25621 tacttagatt tttggtcacg tcttgctact gataatgtcc gtgataaact tcttaagagt
    25681 caaaatgtag ttccaactcc tgtatgggat aatcataata gcccgaacgg atgggctagt
    25741 agacatggtc atatagatgg gaaaccggat tatgctccaa ttcgtgagtt ctttgggcga
    25801 atcaataagt atcatggtta caaatatgga tatggcgcat atgcatatat ttttgcagca
    25861 cctcaaccga tggatgcagt ttatttcgtt atgacagatt taattagtga ctttggaaca
    25921 tctgcattta cacatgaaac tactcacgtt aatgatcgta tggcttacta tggtggtcat
    25981 tggcatcgtg aaggtacgga tcttgaagca tttgctcagg ggatgttaca aacgccatcg
    26041 gtatcaaatc caaacggaga atatggcgca ttaggtctaa atatggcgta tgaacgtcaa
    26101 aatgatggaa atcaatggta taacacaaat ccaaacgacc ttacaactcg tgcagaaatt
    26161 gataactaca tgaaaggttt caacgataca ttaatgcttc ttgattacct tgaaggagaa
    26221 gctgtcctca ataaagcaaa tcaagattta aacaacgctt ggttcaaaaa agtggataag
    26281 caacttcgtg gagctagtac gaagaaccag tatgataaag ttcgtgattt aacggcagat
    26341 gagaaaaata tcactctaaa ttcagtagat gatttagttg ataataattt tatgacgaaa
    26401 cacggacctg gaaacaatgt atatgatcca actgggttcg gaacggccta cgtgactgta
    26461 cctattactg caggtattta tggaggtaac acaagtgaag gtgctcctgg ttctatgtca
    26521 ttcaaacata acacattcag aatgtggggg tactacggat atgaaaaagg attcttaaac
    26581 tatgcttcta acatgctgaa aaatgagtct agacaggctg gtcacaatac tctaggtgat
    26641 gatttcatca ttaagaaagt ttctgataat aaattcagta cattggaaga ttggaagaaa
    26701 gcatacttca aagaagttgt agataaagct aaagcaggat ttaaccctgt tacaatcgac
    26761 ggtactacat atagtagtta cgatgacttg aagaacgcat ttgctgcagc agttgaaaaa
    26821 gataaagcta ctcttaaaaa tggatcagtt aaatctgaca atactgttgc acttaaagag
    26881 aaaatataca aaaaacttct tcaacaaaca gatagcttta aaacttcaat ctttagataa
    26941 tcgaaatctc tcatctgctt tgcggatgag ggttttctta ttttatgcta tacttaaggt
    27001 atgcatagaa aaacagtgat tgattttagg actttagggg agagatatac ctttacccag
    27061 cctattaaag agttgaaaac gagaaatgta gaagaagtgg cagatttgct ggcacaagtg
    27121 gaaagctacc aagagcaagg ttattatgtg gtggggtatg tcagctacga ggctgcacct
    27181 gcttttgagg agaaattaac agttcacaag gttcctctac tgggcgagta cttgctttac
    27241 tttactgttc acgatagggt agagacctcc cctattcctc tgacttatga ggatattgat
    27301 ttgccctcaa attggcagga agtgacgtct gcagcagact atgaaaaggc cattgcccag
    27361 atacaccatc acttgaggca gggagacacc tatcaggtca actacaccgt ccaactcaag
    27421 caaaagttaa gtgccaatcc ttttgctatc tacaatcgta tggtggtaga gcaggaggcg
    27481 ggctacaatg cctacgtgga acatgacgag atggcagtga tttccatgag cccagagctc
    27541 ttttttgagc aaaatgatcg cgagttgaca acacgaccaa tgaaggggac gactcagcgt
    27601 ggggtaactg accaagaaga tcttgaacag gccagttggt tggaacagga tcccaaaaat
    27661 cgctctgaaa atatgatgat tgtggacctc ttgcgcaatg atatgaaccg tatttctgaa
    27721 gttgggagcg agcacgtgga gcgtctgtgt caggtagagc agtattcaac tgtttggcag
    27781 atgacttcga ccatcaagag tcagttgcga gaggatgtgg accttgttga aatcttccgc
    27841 tcactctttc cttgtggttc cataacgggt gcaccgaaaa ttgcgacaat ggagattatc
    27901 aaggacttgg agcctcaacc gcgtggagtc tactgtggaa cgattggtct cttgcttcca
    27961 aatggacgac ggatttttaa tgtggccatt cgtaccattc aacttcacaa agatcaagcc
    28021 atttatggag ttggcggagg gattacttgg gatagcacat gggaatctga ataccgagag
    28081 gttcatcaaa aggcagcagt tctttatcgt aaacaagctc gcttccaact gattacgaca
    28141 gggaaaatca gccagaagaa cctgctgttt gaagatcaac atctggaaag actgagaaaa
    28201 gccagtcgtt attttgcctt tccttttgat gcagaagact tgggacacaa gattgaggaa
    28261 gagtgtcagg attgtgaagc taatcgagat taccgcttgc gaatcagcct tagcaaatct
    28321 ggagagatag aagtcaatcg tcaagtatta acccctctca gtacaagctt ttgtcaggcc
    28381 caagtctgtc ttcaggaagc tgctttgaat caatccttta cctactttaa aaccactcac
    28441 cgaccgcatt tgagcctagg agaacaagag aagatttacc acaataagtc aggagaactg
    28501 cttgaaacct ctataggaaa tttggttctg aaaatcgctg gaaaactcta cacaccgcct
    28561 atccgacttg gaatcttgcc aggaatttac cgtcagcatt tgctagaaac aggacaggta
    28621 gaagagaaag tcttgacctt ggcagattta gcccaagcag aagctattta cggctgtaat
    28681 gcagtgagag gcttgtatga actaagcctt gaggagaact agatgaaatt gatatttttg
    28741 catgggttag ggcagtcagc agagtcttgg aaagaagttc ggaatctact gacagattat
    28801 ccttctgagg ctatcgagtt atttccttct ggagttagta actatcaaca agctaaagag
    28861 cgagtttatc agcacctagc tcaagagaca gaaccttttg ttttgattgg attgtcctta
    28921 ggtgctgccc tgacactaga actttccagt tacgatttac caaatcttcg agctttgatt
    28981 ctgtcaggat gcccgcttaa attagcaggg aatatcctat tttatcttca attgctgatt
    29041 tttaaactac ttcccaaaag agtatttgaa aaacagggag cagacaagac tcttatggtc
    29101 ggagtttctg aggaattgaa gacacttgat ttaacggata tagcagggac ttgctcctat
    29161 ccaaccttac taatttgtgg cagcaaagat aaaccgaatc ttagttctat gaaagctctc
    29221 catagactgt taacagattc gcagtttcag atcattcctg atggccctca tgtcttgaat
    29281 aaggcaaaac caaaggagtt tgtagaaaag accagaagtt tccttgaatt gctgaaataa
    29341 gtttgataaa ataatattga aatcgatatc ataattatgg gagaaagaaa tgaataaacg
    29401 tctattttta aaaatgagtc tggtgacgtt gccaatttta gccttgtttt cacaaccagt
    29461 tttggcggaa gaaaacatcc atttttcgag ctgtaaggaa gcttgggcga atggctattc
    29521 ggatattcac gagggagaac ctggttattc tgccaagtta gaccgtgatc atgatggtgt
    29581 ggcttgcgaa ttgaaaaatg ctcctaaggg tgcttttaaa gcaaaacaag cggctacaac
    29641 tcaaactgat acaacttcat ccacagcaag tggttgggtt aagcaggacg gttcttggta
    29701 ctattttgat ggaaatggaa atctagtgaa aaatgcatgg cagggaaact attacctgaa
    29761 agctgatggt aaaatggcac agagtgaatg gatttatgac tcttcttatc aagcttggta
    29821 ttacttgaaa tcagatggtt catatgctcg caatgcatgg caaggaaact actatttgaa
    29881 atcagatggt aaaatggcta aaggtgaatg ggtttatgat gccacctatc aagcttggta
    29941 ttacttgaaa tcagatggtt catatgctcg caatgcatgg caaggaaact actatttgaa
    30001 atcagatggt aaaatggcta aaggtgaatg ggtttatgat gccacctatc aagcttggta
    30061 ttatttgaca tcagatggtt cttatgctta cagtacatgg caaggaaatt actatctaaa
    30121 atcggatggt aaaatggctg tcaatgaatg ggttgatggt ggacgttatt atgttggcgc
    30181 tgacggagtt tggaaggaag gtcaagcaag tacagcttct tctagtaatg atagcaatag
    30241 tgaatattct gctgctttag gaaaggcaaa gacttataac tcactattcc atatgtcaaa
    30301 aaaacgcatg tatagacaat taacttctga ttttgataaa ttttcaaatg atgcagctca
    30361 atatgccatt gatcatttag atgattaaca gatactggta ggcgaaaaaa ttccttataa
    30421 ttcatttacg caaacctttg cataagtgaa tggattttga tatactagta ctgtaagcat
    30481 tttcaattac tacacaatga aaaaggagaa tatgatgagt caaaagatta ttgggattga
    30541 ccttggcgga acttctatca aatttgcaat cttaacaaca gcaggagaaa tccaaggaaa
    30601 atggtcaatc aagaccaaca ttttggatga gggaagtcat atcgttgatg atatgattga
    30661 gtctattcaa catcgtttgg acttgcttgg attggcagca gcggacttcc aaggcattgg
    30721 aatgggatca ccaggtgtgg ttgaccgtga caaagggact gttatcggtg cctacaactt
    30781 gaactggaaa acccttcaac caatcaaaca aaagattgaa aaagctttgg gcattccatt
    30841 tttcatcgat aatgatgcca acgtagcagc tcttggtgag cgctggatgg gtgctggtga
    30901 taaccaacca gatgttgtct ttatgacact cggtactggt gttggtggtg gtattgtcgc
    30961 agaaggcaaa ttgcttcatg gtgttgctgg tgcagcaggt gaacttggtc atatcactgt
    31021 tgattttgac caaccaattg catgtacttg tggtaaaaaa ggctgtcttg agacagtcgc
    31081 ttctgcaaca ggaattgtca atttgactcg tcgctatgcc gatgaatacg aaggcgatgc
    31141 agccttgaaa cgcttgattg ataacggaga agaagtaact gctaagactg tctttgatct
    31201 cgcaaaagaa ggagacgacc ttgctttgat tgtttaccgt aacttctcac gttacttggg
    31261 aatcgcttgt gctaacattg gttcaatcct aaacccatca acaatcgtca tcggtggtgg
    31321 tgtgtcagct gcgggagaat tccttctaca aggtgttcaa aaagtttacg atgaaaatag
    31381 tttcccacaa gtacgcacat ctactaaatt agctcttgca actctaggaa atgacgctgg
    31441 agttatcgga gcagcatcac ttgtattgca ataagataat gagagaggaa aatgctaacc
    31501 tagagttagt aatgttcctc ttttattttt tatgctatac tagttaggac aatgaatgag
    31561 gtgagagtaa atgacaaaag cagatacgat ttttaaagag aatattgaac gcattctaaa
    31621 ggaaggtgtt ttctcagagc aggctcgtcc taagtacaag gatgggactg ttgctaattc
    31681 caagtatgta actggtgcct tttccgagta cgacttatct aaaggagaat ttcctatcac
    31741 aaccttgcgt cccattgcaa tcaaatccgc catcaaagaa gttctctgga tttaccaaga
    31801 ccagtcaaat agcttagaag tgcttaatga caagtacaat gttcactact ggaatgactg
    31861 ggaagttgga gacacgggaa ccattggtga gcgctatggt gccgttgtta agaaacacga
    31921 cattatcaat aagcttctca aacagttgga aaccaatcct tggaaccgcc gcaatattat
    31981 ttctctctgg gattaccaag ctttcgaaga aacagatggg ctgctcccgt gcgcctttca
    32041 gaccatgttt gatgttcggc gtgttgatgg ggaaatctat ctggatgcga ccttgaccca
    32101 gcgctccaat gatatgctgg tggcccacca catcaacgct atgcagtatg tggctttgca
    32161 gatgatgatt gccaaacatt ttggctggaa ggttgggaag ttcttctact tcatcaacaa
    32221 cctccatatc tatgataatc aatttgaaca agctcaggaa ttgctccgtc gggagccgtc
    32281 aaactgccaa ccacgcttgg ttttaaatgt tcctgatggg actaatttct ttgatatcaa
    32341 agcagaagat tttgagttgg tggattatga ccctgttaag ccacagttga agtttgacct
    32401 agctatttaa aagaatagaa aaagaagttg agaataatcc caacttcttt tgtttcttaa
    32461 cgtgatacgc ggcgacgagc tgctttttta cggttttctt cgatgaaagc tgctttttgc
    32521 tcttctggtt cgattacttt ctttttaaat gcgtatactg cacctgcaac ggcagcgaca
    32581 gttcctgcga cacctgttac aagaccttta gcgaatcctt tagccatgag tcttcctcct
    32641 ttatattctc aatcagccag cctcctcaag aggtcacatt tttctgactg acctttttgt
    32701 gttataataa tagtaacgaa aaaatgggaa tttttcaagg aaaaaagatg aaaacaaaaa
    32761 taattgtgat tgttggaccg actgctgttg gaaagacggc tctagctatt gaagttgcaa
    32821 agcgttttaa tggcgaagtg gttagtggag atagccaaca agtctatcga ggacttgata
    32881 ttgggacggc taaggctagt ccagaagagc aggcagctgt tcttcatcat ttaatcgatg
    32941 ttagagagat aaccgagtct tactcggctt ttgattttgt ttcagaagct aagatgacta
    33001 ttgaggatat tcacagccgt ggcaagctag ccattatcgc cggtgggact ggactttata
    33061 tccagagctt gctagaaggt taccacctag gtggggagac tcctcatgag gagattttag
    33121 cttatcgagc tagtttggag ccatattcag atgaggaatt agcccatttg gtggagcaag
    33181 caggccttga gattccccag tttaatcgtc gtcgtgctat gcgtgcctta gaaattgccc
    33241 attttggtca ggatttggaa aatcaagaga ccttgtatga accgctgatt atctgcttgg
    33301 atgatgaacg tagtcaactt tatgagcgta tcaaccaccg agtggatttg atgtttgagg
    33361 ctgggctttt ggatgaggcc aagtggctgt ttgaccattc ccctaatgta caggctgcta
    33421 aaggaattgg ctataaggaa ctctttcctt atttccgtgg agagcagacc tttgaggaag
    33481 ctagtgagag tcttaaacag gcgacccgtc gttttgccaa gcgtcagctg acctggttcc
    33541 gtaatcgcat gcaggtcacc ttttatcaga ttggagaatc tggtgtacaa gaccgcattt
    33601 taagccagat agaggagttt ttagatgatt gaaacggaga aaaaagagga gcgagtcctg
    33661 ctgattggtg tggaattgca gggtatggac agttttgacc tctccatgga agaattggct
    33721 agtttagcga aaacggcagg ggcagtcgtt gtagatagct acagacaaaa acgtgaaaaa
    33781 tatgattcca agaccttcgt cggctctggt aagttggaag agattgcgct tatggtggat
    33841 gcagaagaaa tcactactgt catcgtcaac aatcgtctga ccccaaggca gaatgtcaat
    33901 ctagaggaag ttctcggtgt taaggtcatt gaccgtatgc agttgatttt ggatatcttt
    33961 gccatgcggg ctcgaagcca tgaagggaag ctccaagtcc acctagccca actcaaatac
    34021 cttttgcctc gcttggttgg tcaggggatt atgctcagcc gtcaggcagg gggaattggt
    34081 tcccgtggtc ctggtgaaag ccagctggag ctgaaccgtc gtagcgttcg caatcaaatc
    34141 acggatatcg agcgccagct caaggtggtt gagaaaaatc gggcgactgt cagagaaaaa
    34201 cgtttggagt ctagcacctt taagattggt ttgattggtt ataccaatgc tgggaaatca
    34261 actatcatga acatcttgac cagtaagacc cagtatgaag cagatgagct ctttgcgact
    34321 ctggatgcga caaccaagag tattcatctg ggaggcaatc tccaagtaac tttgacagat
    34381 accgttggct ttattcaaga tttgccgaca gagttggtgt ccagtttcaa gtcaaccttg
    34441 gaagaaagca agcatgtgga ccttctggtt catgttatcg atgctagcaa tccttaccac
    34501 gaggagcatg aaaaaacggt tctctccatc atgaaagacc tggacatgga agatattcct
    34561 cacttgacgc tttataataa agcggatttg gtggaggatt tcacgcctac ccaaacgcca
    34621 tataccctca tttctgccaa gtctgaggac agtcgtgaaa acttgcaagc attattgcta
    34681 gataagatta aggaaatttt tgaagcattt accctgcgag tgcctttttc aaagtcctac
    34741 aagattcatg atttagagag tgttgcaatt ctggaagaac gtgattatca ggaagacggc
    34801 gaagtgatta caggctacat ttccgagaaa aataaatgga ggttagaaga attttatgac
    34861 tgatattaaa actttggctc taaagtatgg aggttataca agtctggaca aggtctatct
    34921 ggatcagctt ctagctggta aaacagagca ggagcagtta acacttatta cacctccgcc
    34981 aagtgttgtt aatgcctact ttgcagaact ctatcagaaa aaaagtcctc aggctgcgac
    35041 ggattatttt gcagaactca gtcaggaact gaatctttac aatactgaac caagtttcac
    35101 cctagaaaat aagcctttta ttcggcttaa tctgtctggt aaatcctttg gtttttgtta
    35161 tgagagtgac ggctttggtc ggattttctc tgaaaatgag gagaaaatct cggatgactt
    35221 gctctttgaa attgcgcaaa ttttctccca tcaattagtc tttgaagagt ctggtaagat
    35281 ttacatgaag cctgtcaagg acgaggaagt tgtcagccta gaaagtctca cagctttgac
    35341 tgatttggaa agattggctg atggtcgaaa acgtctcaaa ggctacagcc aagaggattt
    35401 attgcaagaa gctgctgctt tttctggcaa acgctatttc cgatcggaaa accgcacagc
    35461 catgttatat attgattaat tagaaagtat cgaatggata ttcaattttt aggaacgggg
    35521 gctggtcagc cctctaaagc ccgcaacgtt tcaagtctcg ccctgaaact tttggacgag
    35581 attaacgaag tttggctctt tgactgtgga gaaggtacgc aaaatcgcat tctggaaacc
    35641 acaattcgac cacgtaaggt cagcaaaatc tttattaccc atctgcatgg agaccacatt
    35701 tttggtttgc caggtttcct ttctagccgt gcctttcagg ccaatgaaga gcagacagat
    35761 ttggaaatct acggacctca aggaatcaag tcatttgtct taaccagcct tcgtgtgtca
    35821 ggttctcgtc tgccctaccg cattcatttc catgagtttg accaagattc tctgggtaaa
    35881 attcttgaaa ccgataaatt cactgtgtat gcagaggagc tggaccacac tattttctgt
    35941 gttggctatc gtgtcatgca aaaggatcta gaagggacgc tggatgctga aaaactcaag
    36001 gctgctggtg ttccgttcgg cccgcttttt ggtaaaatca aaaacggcca ggatcttgtt
    36061 ttggaagacg gaactgaaat caaggcagca gactatatct cagcgccacg tccaggtaag
    36121 attatcacta ttttaggaga cactcgaaaa acggatgcca gtgtgcgtct ggctgtcaat
    36181 gcagatgtcc tagttcatga gtccacttat ggcaagggtg atgaaaaaat tgctcgtaac
    36241 catggtcact caactaatat gcaagctgca caagtagcgg tagaagcagg tgccaaacgc
    36301 ctcctactca accatatcag tgcccgtttc ctctcaaaag atataagcaa actcaagaag
    36361 gacgctgcca caatttttga aaatgtccat gtggtcaaag acttggaaga agtggaaatc
    36421 tagcagtcac agaaaggata agtatgccta ctattctcat taccggagct agcggtggtc
    36481 tagctcaaga aatggtcaaa ctcctgccca atgaccaact catcttgctt ggtagaaata
    36541 aggaaaaatt agcccaactc tacggaaatt attcccatgc agaattgatt gaaattgata
    36601 ttaccgacga ttcagcccta gaagctctgg taactgatct ttatctccgc tatggcaaga
    36661 ttgatgtctt gattaacaac gctggttacg ggatttttga gggatttgac cagattgctg
    36721 ataaagatat tcaccagatg tttgaggtca atacctttgc cctgatgaat ctgtctcgtc
    36781 accttgcggc tcgtatgaag gaaagcagca aagggcatat catcaacatc gtcagcatgg
    36841 caggtctaat agctactggc aagtctagtc tttactcagc gaccaagttt gcggctattg
    36901 gtttttcaaa tgctctgcga ctcgaactta tgccctatgg agtctatgtg acaacagtca
    36961 atccaggtcc aatccgaaca ggattttttg accaagctga cccagatgga acttatctta
    37021 aatcggttga ccgcttcctc ttagaggcag atgcagtggc taaaaagatt gtcaagatta
    37081 taggaaaaaa taaacgagaa ctcaatctcc cgattttgtt gaacctagcc cataagtttt
    37141 atactctctt tcccaagcta gctgataagt tggcagggga aacttttaat tataagtaaa
    37201 aagaaccaat gtgcaggttg ttgctagcct acatattggt tcttatcatt tctcaactat
    37261 caaactgaac ttcttctagt agatagtcga taaagcgttc gcccatctta gataggctgg
    37321 ttttctcatg ctggatatag accagctcaa tcgggtcatc aatatccagt gggatagaaa
    37381 cgatattgtc tccgtttagg ttgctgttca aaatccctgt cgcaatggta taaccatcca
    37441 aaccaatcaa gagattaaag agggtggcac ggtcactgac cacaatggat ttcttgtggt
    37501 gttcttgaga aagaatctct tctgaaaagt agaaggagtt gtgcgtccct tggtcatagc
    37561 tgaggtaagg gaaattctcc aaatcagaca gtttcacctt gtctttcttt gccagagggt
    37621 tggtcttgct gacaaagata tgcggttgcg ctgtgaagag atggtgggct agtaggtgat
    37681 tgtcatccag catcttggtt aaaacatcac ggttgtaact gtttaagaag aggaccccga
    37741 cctcactgcg gaagttcttg acgtcgtcga taatctccca agtccgagtt tcacgaagga
    37801 aaagctcgta tttctccata tcgcttttct tgagcaaaga gacaaaggca ttgaccacaa
    37861 aggcatagtg ttgagacgaa acgctaaaga gttcgcggtg ggcgacagga tttttatagc
    37921 gttcctccag aagctgagtt tgctcgacaa cctgacgggc ataagagaga aactccatcc
    37981 catcacgggt caaggtgatt cccttgggat tgcggataaa gatctcaatg cccatttcat
    38041 tttccaaatc tctcacagca ttggaaagac ttggctgagt gataaagagt tgcttggctg
    38101 cctcattcat agagccagtt tcgacgattt tgataatata atgtaattgt tgaattctca
    38161 tgtttttatt gtaccacact tgccttagaa tcgccaaaga agataggaaa ataaggagca
    38221 ttgtgtgagt ctcttcttga aaaaaacaca aaattttgct agaatgagtc ttatgaaaac
    38281 attctatgat gtgcagcaat tcctcaaacg atttggtatt attgtttaca tgggaaaacg
    38341 cttatatgat attgaactga tgaagttgga actatctcgg atttacgatg cagggttgat
    38401 ggataaatta gactatctag aggcagaagc agttcttcgc agagagcaca aggtagaatt
    38461 ggattatatt gagaaaaatg gagaaaagaa ctaatggtta cttggatttt gtgggcactt
    38521 atactagcaa tgttggcgtg gatgggcttt aactatcttc gtattcgtcg tgcggctaaa
    38581 attgtggaca atgaggagtt tgaagccttg attcgtacgg gtcaattgat tgatttgcgc
    38641 gacccagcag aattccacag aaaacatatc cttggtgcac gcaatattcc ttcaagtcag
    38701 ttgaaaacta gtcttgcagc ccttcgtaaa gataaacctg tccttctcta cgagaaccaa
    38761 cgtgcgcaac gagttacaaa tgcagctctt tacttgaaaa aacaaggttt ttctgagatt
    38821 tatatccttt cttatggctt ggattcttgg aaagggaaag tgaagactag ctaaccttat
    38881 ttccaaatta gtcgaatgat aggatgaagc tattgtttta tagtataatt aatttgtata
    38941 aaatttaaag agttcttaga acatgaaaga aaagaagaaa aatccacttt ttgtgggtat
    39001 cttgtcgatt attcttggtt tgttatttcc aattgtaggc ttgattttgg gtatcatagg
    39061 attggtcttg gctatttcat accaaaaaga gtcacaatta gactataaaa tagaaaagat
    39121 tcttaatatc ttaggaattg tgatttctgt agttaactgg attgtagcaa tcgccttaat
    39181 ttttcggtaa ataaaagaaa aaagctttag ttttaaagct ttttttgttt tatcgactca
    39241 tctctaaata gtttttaatg atttgtaact ctttttggtt caaagggcgg tagttacttt
    39301 ctgctaaatc tgggttcaat gtgaagtccc caaattggat tcttttgagg ctagtcacct
    39361 taacaccaac cgagaggaac attttcttga tttgatgaaa ttttccttct gaaatggtga
    39421 tagaggcttg actgagggag ggacttgcag atagaatctc tagttttgcg ggtttacaga
    39481 cagtaccatc taaaaagaca attccctttt gaaaggcttg gatatggtca ggtgttagaa
    39541 gtccattaac ctggacttgg taagtcttat cgacatgata ttggggatgg aggagctgaa
    39601 agcccaaggg accgctatcg gtcaagagga ggagtcccgt tgtatctcgg tccagtcggc
    39661 caacggcata gagcttgtca gactggatgt cagatggaag caggtccatg acggtcggaa
    39721 gttccttgtc tttgttggct gtaacgacac cagcaggctt atgaagcata agataggtgt
    39781 gttcatagcc ttgaatgatt cgatcctgaa aaaggagttc ttgtagtcct gtatcgatat
    39841 tttgagctag ggatcgggct gggcaaccat cgactagaat ttcccctttg agtaaggctt
    39901 gtttcatggc ctttcggctg attttttctt gagctaataa attatctaaa cgcatactgt
    39961 gcctatctta tcataagtcg cttgctttga aaaggcttga cgtgaaaaga aaagtggagt
    40021 gaaaacattt acacttgctt gagttatgtt atttacttga aattatggta taatcgttca
    40081 gttagaaaat aaattttgaa tattatagag gaaatcatga caaaattaag agaagatatc
    40141 cgtaacattg cgattatcgc ccacgttgac cacggtaaaa caaccctggt tgacgaatta
    40201 ttgaaacaat cagaaacgct tgatgcacgt actgaattgg cagagcgtgc tatggactca
    40261 aacgatatcg aaaaagagcg tgggattacc atccttgcta aaaatactgc cgttgcttac
    40321 aacggaactc gtatcaacat tatggacaca ccaggacacg cggactttgg tggagaagtt
    40381 gagcgtatca tgaaaatggt tgacggtgtt gtcttggtcg tagatgccta tgaaggaacc
    40441 atgccacaaa ctcgtttcgt attgaaaaaa gccttggaac aagaccttgt cccaatcgtg
    40501 gttgttaaca aaatcgataa gccatcagct cgtccagcag aagtagtgga tgaagtcttg
    40561 gaacttttca tcgagcttgg tgcagatgac gaccagcttg atttcccagt ggtttatgct
    40621 tcagcgatca acggaacttc ttcattgtca gatgatccag ctgaccaaga agcgactatg
    40681 gcaccaatct ttgacacgat tatcgaccat atcccagctc cagtagataa ctcagatgag
    40741 cctttgcagt tccaagtgtc acttttggac tacaatgact tcgttggacg tatcggtatc
    40801 ggtcgtgtct tccgtggtac agttaaggtt ggggaccaag ttaccctttc taaacttgac
    40861 ggtacaacta aaaacttccg tgttacaaaa ctcttcggtt tctttggttt ggaacgtcgt
    40921 gaaatccaag aagccaaagc gggtgacttg attgccgttt caggtatgga agacatcttt
    40981 gtcggtgaaa ccatcactcc gacagatgca gtagaagctc ttccaatcct acacatcgat
    41041 gagccaactc ttcaaatgac tttcttggtc aacaactcac catttgctgg taaagaaggt
    41101 aaatgggtaa cttctcgtaa ggtggaagaa cgcttgcagg cagaattgca aacagacgtt
    41161 tcccttcgtg ttgacccaac tgattcacca gataaatgga ctgtttcagg acgtggagaa
    41221 ttgcacttgt caatccttat cgaaacaatg cgtcgtgagg gctatgaact tcaagtatct
    41281 cgtccagaag ttatcgtaaa agaaatcgac ggtgttaaat gtgaaccatt tgaacgtgta
    41341 caaatcgaca ctccagaaga ataccaaggg tctgttatcc aaagcctttc tgaacgtaaa
    41401 ggtgaaatgt tggatatgat ttcaactggt aatggtcaaa ctcgtttggt cttccttgtt
    41461 ccagcgcgtg gtttgattgg atactcaact gagttcttgt caatgactcg tggttacggt
    41521 atcatgaacc ataccttcga ccagtacttg ccattgattc caggggaaat tggtggacgt
    41581 caccgtggtg cccttgtttc tatcgatgct ggtaaggcta caacttactc aatcatgtct
    41641 atcgaagaac gtggtacgat ctttgtcaac ccaggtactg aggtttatga aggaatgatc
    41701 atcggcgaaa actctcgtga aaatgacttg acagttaaca tcacgaaggc aaaacaaatg
    41761 accaacgttc gttcagctac taaggaccaa acagctgtta tcaagacgcc tcgtatcttg
    41821 acacttgaag agtctcttga gttcttgaac gacgatgagt acatggaagt aacgcctgag
    41881 tctatccgtt tgcgtaaaca aatccttaac aaagcagagc gtgagaaagc taacaagaag
    41941 aaaaaatcag ctgaataaga gctagaaaga gagaaagatg gtctatttag tcctaggaat
    42001 tttactgctc ctactctatg tatttgcgac accagaaagc attaaaggga cagtcaatat
    42061 cgtcgctatg gtatgtattt tagtggcact cttgatttta ttggttctat cttttctgaa
    42121 aatttttcaa ttaccaacag aaatattcct agcaatagcc atgttgatcc tagcttactt
    42181 tagtgtgaga gacatcacac tcatgccagt caaaaaaagt aaaagaagat aaaaaagaga
    42241 gttttggctc tcttttttgc taggaatttt acaagattgc aatttatttt tgagttatca
    42301 ccatctcttt tgtttggata atatgaatgg gaaaaacttg aataaaattc tttaatggaa
    42361 tctattttat atttgcttag tactg
//
LOCUS       DAVHIZ010000015        40313 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.015, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000015 DAVHIZ010000000
VERSION     DAVHIZ010000015.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 40313)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40313)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40313
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.015"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            5..75
                     /locus_tag="VVO18_000784"
     tRNA            5..75
                     /locus_tag="VVO18_000784"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:37..39,aa:Gly,seq:tcc)
     gene            110..183
                     /locus_tag="VVO18_000785"
     tRNA            110..183
                     /locus_tag="VVO18_000785"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:144..146,aa:Ile,seq:gat)
     gene            266..355
                     /locus_tag="VVO18_000786"
     tRNA            266..355
                     /locus_tag="VVO18_000786"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:302..304,aa:Ser,seq:tga)
     gene            366..439
                     /locus_tag="VVO18_000787"
     tRNA            366..439
                     /locus_tag="VVO18_000787"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:400..402,aa:Met,seq:cat)
     gene            443..515
                     /locus_tag="VVO18_000788"
     tRNA            443..515
                     /locus_tag="VVO18_000788"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:476..478,aa:Phe,seq:gaa)
     gene            528..608
                     /locus_tag="VVO18_000789"
     tRNA            528..608
                     /locus_tag="VVO18_000789"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:562..564,aa:Tyr,seq:gta)
     gene            613..683
                     /locus_tag="VVO18_000790"
     tRNA            613..683
                     /locus_tag="VVO18_000790"
                     /product="tRNA-Trp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:645..647,aa:Trp,seq:cca)
     gene            698..770
                     /locus_tag="VVO18_000791"
     tRNA            698..770
                     /locus_tag="VVO18_000791"
                     /product="tRNA-His"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:731..733,aa:His,seq:gtg)
     gene            781..852
                     /locus_tag="VVO18_000792"
     tRNA            781..852
                     /locus_tag="VVO18_000792"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:813..815,aa:Gln,seq:ttg)
     gene            862..945
                     /locus_tag="VVO18_000793"
     tRNA            862..945
                     /locus_tag="VVO18_000793"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:896..898,aa:Leu,seq:caa)
     gene            1052..2329
                     /locus_tag="VVO18_000794"
     CDS             1052..2329
                     /locus_tag="VVO18_000794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamylcysteine synthetase"
                     /protein_id="HEU5585980.1"
                     /translation="MSCSIDLLKHRYLKNIKENPELFVGIELEYPVASLEGDATDVEV
                     IKDLFHYLVSTLDLTVAKVDDFGNLIQLVDPISQDAILFEVSYTTIEFAFGKAETIQE
                     VENRFNNYMNVIQRKLAESNHAIVGCGIHPNWDKNENCPVAYPRYQMLMDYLNLSRNI
                     IKSDLHHFPEYGTFICGSQVQLDISKTNYLRVINAFTQIEAAKAYFFANSEFSGADWD
                     TKISRDIFWEESMHGIYPENVGVNARLLNDEADFFDYLNHSAIFTAERDGQTYYFYPI
                     QAGDYLATPEIQAFALNGDEVIISPQEKDFETHRSYQYQDLTTRGTVEFRSVCTQPLD
                     RTFASAAFHLGLLVNLDKLEAYLETAPFFKVFGYDYKSLRRQFSKKNLTDEEETTIIE
                     FSKDLLLLAEEGLVVRNKEEMTYLQPLREELSL"
     gene            2405..3889
                     /locus_tag="VVO18_000795"
     CDS             2405..3889
                     /locus_tag="VVO18_000795"
                     /EC_number="4.2.3.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006595200.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine synthase"
                     /protein_id="HEU5585981.1"
                     /translation="MTLVYQSTRDANNTVTASQAILQGLATDGGLFTPVTYPKVDLDF
                     DKLKDTSYQEVAKLVLSAFLDDFTAEELDYCINNAYDSKFDTPAIAPLVKLDGQYNLE
                     LFHGSTIAFKDMALSILPYFMTTAAKKHGLENKIVILTATSGDTGKAAMAGFADVPGT
                     EIIVFYPKDGVSKIQELQMTTQTGDNTHVIAIDGNFDDAQTNVKHMFNDVALREKLTT
                     NKLQFSSANSMNIGRLVPQIVYYVYAYAQLVKTGEIVAGDKINFTVPTGNFGNILAAF
                     YAKQIGLPVGKLICASNDNNVLTDFFKTRVYDKKREFKVTTSPSMDILVSSNLERLIF
                     HLLGNNAEKTVELMNALNTQGQYKLTDFDAEILDLFAAEYATEEETAAEIKRVCELDS
                     YIEDPHTAVASAVYKKYQSATGDVTKTVIASTASPYKFPVVAVEAVTGKAGLTDFEAL
                     AQLHEISGVAVPPAVDGLEISPIRHKTTVAAADMQAAVEAYLGL"
     gene            3950..5230
                     /locus_tag="VVO18_000796"
     CDS             3950..5230
                     /locus_tag="VVO18_000796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473957.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEU5585982.1"
                     /translation="MFKKNKDILNIALPAMGENFLQMLMGMVDSYLVAHLGLIAISGV
                     SVAGNIITIYQAIFIALGAAISSVISKSIGQKDQSKLAYHVTEALKITLLLSFLLGFL
                     SIFAGKEMIGLLGTERDVAESGGLYLSLVGGSIVLLGLMTSLGALIRATHNPRLPLYV
                     SFLSNALNILFSSLAIFVLDMGIAGVAWGTILSRLVGLVILWSQLKLPYGKPTFGLDK
                     ELLTLALPAAGERLMMRAGDVVIIALVVSFGTEAVAGNAIGEVLTQFNYMPAFGVATA
                     TVMLLARAVGEDDWKRVASLSKQTFWLSLFLMLPLSFSIYVLGVPLTHLYTTDSLAVE
                     ASVLVTLFSLLGTPMTTGTVIYTAVWQGLGNARLPFYATSIGMWCIRIGTGYLLGIVL
                     GWGLPGIWAGSLLDNGFRWLFLRYRYQRYMSLKG"
     gene            5234..5854
                     /locus_tag="VVO18_000797"
     CDS             5234..5854
                     /locus_tag="VVO18_000797"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001172828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU5585983.1"
                     /translation="MQKTAFIWDLDGTLLDSYEAILSGIEETFAQFSIPYDKEKVREF
                     IFKYSVQDLLVRVAEDRNLDVEVLNQVRAQSLAEKNAQVVLMPGAREVLAWADESGIQ
                     QFIYTHKGNNAFTILKDLGVESYFTEILTSQSDFVRKPSPEAATYLLDKYQLNSDNTY
                     YIGDRTLDVEFAQNSGIQSINFLESTYEGNHRIQALADISRIFETK"
     gene            6020..7162
                     /locus_tag="VVO18_000798"
     CDS             6020..7162
                     /locus_tag="VVO18_000798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEU5585984.1"
                     /translation="MKKRMLLASTVALSFAPVLATQAEEVLWTARSVEQIQNDLTKTD
                     NKTSYTVQYGDTLSTIAEALGVDVTVLANLNKITNMDLIFPETVLTTTVNEAEEVTEV
                     EIQTPQADSSEEVTTATADLTTNQVIVDDQTVQVADLSQPIAEAPKEVASSSEVTKTV
                     IASEEVAPSTGTSVPEEQTAETSSAVAEEAPQETTPAEKQETQASPQAASAVEVTTTS
                     SEAKEVASSNGATAAVSTYQPEETKIISTTYEAPAAPDYAGLAVAKSENAGLQPQTAA
                     FKEEIANLFGITSFSGYRPGDSGDHGKGLAIDFMVPERSELGDKIAEYAIQNMASRGI
                     SYIIWKQRFYAPFDSKYGPANTWNPMPDRGSVTENHYDHVHVSMNG"
     gene            complement(7148..7294)
                     /locus_tag="VVO18_000799"
     CDS             complement(7148..7294)
                     /locus_tag="VVO18_000799"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585985.1"
                     /translation="MKFQIKLTWFEEIFEEYDKEKTNENRLPSRKLDLIRQNDVIKSG
                     LSIH"
     gene            7485..7910
                     /locus_tag="VVO18_000800"
     CDS             7485..7910
                     /locus_tag="VVO18_000800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HEU5585986.1"
                     /translation="MLEIQDLLYQLRLSEQASTQLFEKRLGISLTRYQILLFLLEHSP
                     CNQMAIQERLKIDQAALTRHFKILETEGLVERHRNPENQREVLVEAAKYAKEQLVVNP
                     PLQHIKVKEEMESILTEFERTELSRLLNKLVLGIENIEI"
     gene            7921..8322
                     /locus_tag="VVO18_000801"
     CDS             7921..8322
                     /locus_tag="VVO18_000801"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1304 domain-containing protein"
                     /protein_id="HEU5585987.1"
                     /translation="MSIITIILTTIVALEHFYIFYLESIATRSDATSRVFNMEKEELA
                     HPSVSSLFKNQGIYKALLGVFLWYGIYFSQNLEIVTIFVLFVIGAATYGSLTADKKII
                     LKQGGSAILALISILLFKIHLKVDSNLANPF"
     gene            8397..9041
                     /gene="pcp"
                     /locus_tag="VVO18_000802"
     CDS             8397..9041
                     /gene="pcp"
                     /locus_tag="VVO18_000802"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HEU5585988.1"
                     /translation="MKVLVTGFEPFGGEKGNPTLEAIKGLPAEIHGAEVRWLEVPTVF
                     HKSAQVLEEEMNRYQPDFVLCIGQAGGRTSVTPERVAINQDDARISDNEDNQPIDRPI
                     RPDGASAYFSSLPIKAMVQAIKKEGLPASVSNTAGTFVCSHLMYQALYLVEKKFPYVK
                     AGFMHIPYMMEQVVNRPTTPTMSLVDIRRGIEAAIGAMIEHGDQELKLVGGETH"
     gene            complement(9069..9926)
                     /locus_tag="VVO18_000803"
     CDS             complement(9069..9926)
                     /locus_tag="VVO18_000803"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF975 family protein"
                     /protein_id="HEU5585989.1"
                     /translation="MNYPKIDLKTIRQESKHFQADTPRLFLLYILPSMLVILSSFLNP
                     LSRIHGTVLEQPFFSILGQILQAYLFPLLVSFIGTILLTSSVYATLTLMKDSKTEPSV
                     KNSLALFDEERFSQTFLTLLLKRFYLFLWSIPNLLGIYLLFYSSFLAKKFVTLHPEFP
                     NLDLSSVETERFLMVFGLYFLASLILIIVGNILYIPQYYAYSQVEFLLCYSLDLGQVP
                     PRRILKTSRSFMKGYKFQHFVLDLQLLPWYFLNWITFGIASFSLLPYIQCTKIMFYRA
                     VLARKRPKA"
     gene            10056..11198
                     /gene="tgt"
                     /locus_tag="VVO18_000804"
     CDS             10056..11198
                     /gene="tgt"
                     /locus_tag="VVO18_000804"
                     /EC_number="2.4.2.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004298827.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="HEU5585990.1"
                     /translation="MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQAT
                     VKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQV
                     YSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYD
                     YVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSI
                     GGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTR
                     IARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIR
                     LTSYHNLYFLLNLMKQVRQAIMDDNLLEFRKYFVEKYGYNKSGRNF"
     gene            11299..13116
                     /locus_tag="VVO18_000805"
     CDS             11299..13116
                     /locus_tag="VVO18_000805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetyltransferase"
                     /protein_id="HEU5585991.1"
                     /translation="MRIKWFSLIRIIGLLLVLLYHFFQTIFPGGFFGVDVFFTFSGFL
                     ITALLIEEFSKNHEIDLIGFFRRRFYRIVPPVVLMVLVTMPFTFLVRQDYVAGIGGQI
                     AGVLGFMTNFYELLTGGSYESQFIPHLFVHNWSLAVEVHYYILWGLAVWFLSKQAKSN
                     GQLKGMVFLLSAAAFLISFFSMFIGSFLVTSYSSVYFSSLTHVYPFFLGSMLATIVGV
                     RQTTSLVKQLDKIWDLRKTLVVFGGGFGFLVLLTFFVKFTYLFAYLIGFLLASLAALA
                     MILAARVLHEKTHHIQEPKIISFLADTSYAVYLFHWPFYIIFSQLTSNLLAVLLTLIC
                     SYGFASLSFYVLEPWIAGKNTPIVQTLRPLPYIHAILAAGTGILTIIVCTVTLLAPQV
                     GAFETDLTVNGLKQAATNIGQTKVMAERADANSLGIADGTMLIGDSVALRANTALQTA
                     LPGAQINAQVSVTTKTANEIMLNNSQNKFLPKTVVIATGVNNPENYKDDWDSIVKNLP
                     KGHHMILVTPYEGDKTKETYAIVEKAAAYMRELAEKTPYITIADWNQVAKEHPEIWAG
                     TDQVHFGSESSTIEAGAKLYADTIATALQTAQDKPVKSK"
     gene            13269..14420
                     /gene="nagA"
                     /locus_tag="VVO18_000806"
     CDS             13269..14420
                     /gene="nagA"
                     /locus_tag="VVO18_000806"
                     /EC_number="3.5.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="HEU5585992.1"
                     /translation="MPNYIKADQFFYPHGVRRGGYLELVDGKFGKHVEQISEGAEVID
                     YTGYSIAPGLVDTHIHGYAGVDVMDNNIEGTLHTMSEGLLSTGVTSFLPTTLTATYEQ
                     LLAVTENLGNHYKEATGAKIRGIYYEGPYFTETFKGAQNPTYMRDPGVEEFHSWQKAA
                     NGLLNKIALAPERDGVEDFVRTVTGEGVTVALGHSNATFAEAKKAVDAGASVWVHAYN
                     GMRGLTHRELGMVGAMYQLPHTYAELICDGHHVDPKACEILIKQKGTENIALITDCMT
                     AGGLEDGDYMLGEFPVVVANGTARLKSTGNLAGSILKLKDGLKNVVEWGIANPHEAVM
                     MASFNPAKSVHIDDVCGQIREGYDADFIVLDKDLELVATYLDGVKRYQA"
     gene            14583..15641
                     /locus_tag="VVO18_000807"
     CDS             14583..15641
                     /locus_tag="VVO18_000807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000649458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /protein_id="HEU5585993.1"
                     /translation="MKAYTYVKPGLASFVDVDKPVIRKPTDAIVRIVKTTICGTDLHI
                     IKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLISCVCACGKCYYCKKGIYA
                     HCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHTPEDLSDEALVMLSDILPTGYEIGV
                     LKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIMVDLDDNRLETALSFGATHKVN
                     SSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKIIGVDGTVANCGVHGKPVEF
                     DLDKLWIRNINVTTGLVSTNTTPQLLKALESHKIEPEKLVTHYFKLSEIEKAYEVFSK
                     AADHHAIKVIIENDISEA"
     gene            15792..16157
                     /locus_tag="VVO18_000808"
     CDS             15792..16157
                     /locus_tag="VVO18_000808"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1033 family protein"
                     /protein_id="HEU5585994.1"
                     /translation="MYRVIEMYGDFEPWWFLEGWEEDIVASRKFDQYYDALKYYKTCW
                     FRLEQESPLYKSRSDLMTIFWDPEDQRWCDECDEYLQQYHSLALLQDEQVIPDEKLRS
                     GYEKQTSQERNRSCRMKLK"
     gene            16233..17174
                     /locus_tag="VVO18_000809"
     CDS             16233..17174
                     /locus_tag="VVO18_000809"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000249584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II/IV secretion system protein"
                     /protein_id="HEU5585995.1"
                     /translation="MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIG
                     SYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKIASLRLSTVGDYRGHESL
                     VIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
                     VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVV
                     RASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFAN
                     RDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS"
     gene            17122..18138
                     /locus_tag="VVO18_000810"
     CDS             17122..18138
                     /locus_tag="VVO18_000810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000355375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system F family protein"
                     /protein_id="HEU5585996.1"
                     /translation="MDISQVFRLRRKKLATAKQKNIITLFNNLFSSGFHLVETISFLD
                     RSALLDKQCVTQMRVGLSQGKSFSEMMESLGCSSAIVTQLSLAEVHGNLHLSLGKIEE
                     YLDNLAKVKKKLIEVATYPLILLFFLLLIMLGLRNYLLPQLDSSNIATRIIGNLPQIF
                     LGMVGLVSVLALLALTFYKRSSKMSVFSILARLPFIGIFVQTYLTAYYAREWGNMISQ
                     GMELTQIFQMMQEQGSQLFKEIGQDLAQTLKNGREFSQTIGTYPFFRKELSLIIEYGE
                     VKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIVLLYAAMLMPMYQNM
                     EVNF"
     gene            18140..18466
                     /gene="comGC"
                     /locus_tag="VVO18_000811"
     CDS             18140..18466
                     /gene="comGC"
                     /locus_tag="VVO18_000811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738626.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="comG operon protein ComGC"
                     /protein_id="HEU5585997.1"
                     /translation="MKKMMTFLKKSKVKAFTLVEMLVVLLIISVLFLLFVPNLTKQKE
                     AVNDKGKAAVVKVVESQAELYSLEKNEDASLSKLQADGRITEEQAKAYKEYHDKNGVA
                     NRKVND"
     gene            18459..18863
                     /locus_tag="VVO18_000812"
     CDS             18459..18863
                     /locus_tag="VVO18_000812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II secretion system protein"
                     /protein_id="HEU5585998.1"
                     /translation="MIKAFTMLESLLALSLVSILALGLSGSVQSTFAAVEEQIFFMEF
                     EELYRETQKRSVASQQKTSLNLDGQTISNGSQKLPVPKGIQAPSGQSITFDRAGGNSS
                     LAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN"
     gene            18868..19128
                     /locus_tag="VVO18_000813"
     CDS             18868..19128
                     /locus_tag="VVO18_000813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5585999.1"
                     /translation="MILLEAVVALAIFASIATLLLGQIQKNRQEEAKILQKEEVLRVA
                     KMALQTGQNQVNINGVEIQVFSSEKGLEVYHGSEQLLAIKEP"
     gene            19091..19552
                     /locus_tag="VVO18_000814"
     CDS             19091..19552
                     /locus_tag="VVO18_000814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000250539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEU5586000.1"
                     /translation="MVQNSCWQSKSHKVKAFTLLESLLALLVISGGLLLFQAMSQLLI
                     SEVRYQQQSEQKEWLLFVDQLEAELDRSQFEKVEGNRFYMKQDGKDIAIGKSKSDDFR
                     KTDASGRGYQPMVYGLKSAQITEDNQLVHFRFQFQKGLEREFIYRVEKEES"
     gene            19530..19943
                     /locus_tag="VVO18_000815"
     CDS             19530..19943
                     /locus_tag="VVO18_000815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence protein ComGF"
                     /protein_id="HEU5586001.1"
                     /translation="MWKKKKVKAGVLLYAVTMAAIFSLLLQFYLNRQVAHYQDYALNK
                     EKLVAFAMAKRTKDKAEQESGEQVFNLGQVSYQNKKTSLVTTVRTDKSQYEFLFPSVK
                     IKEEKRDKKEEVATDSSEKAEKKKSEEKPEKKENS"
     gene            20080..20667
                     /locus_tag="VVO18_000816"
     CDS             20080..20667
                     /locus_tag="VVO18_000816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU5586002.1"
                     /translation="MKHDFNHKAETFDSPKNIFLANLVCQAVEKQIDILSDKEILDFG
                     GGTGLLALPLAKQAKSVTLVDISEKMLEQARLKAEQQAIKNIQFLEQDLPKNPLEKEF
                     DCLAVSRVLHHMPDLDAALSLFHQHLKEDGKLIIADFTKTEANHHGFDLAELENKLIE
                     HGFSSVNSQILYSAEDLFQGNYSEFFLIVAQKSLA"
     gene            20728..21681
                     /locus_tag="VVO18_000817"
     CDS             20728..21681
                     /locus_tag="VVO18_000817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000345081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU5586003.1"
                     /translation="MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGET
                     ELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQTEPLQANHQFTPDAIALLLVFIV
                     EELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEMDDLLIDLAASMADVIGLQ
                     AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGL
                     KYLKSDGYAIFLAPSDLLTSPQSDLLKEWLKEEASLVAMISLPENLFANAKQSKTIFI
                     LQKKNEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI"
     gene            21732..22922
                     /locus_tag="VVO18_000818"
     CDS             21732..22922
                     /locus_tag="VVO18_000818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetate kinase"
                     /protein_id="HEU5586004.1"
                     /translation="MTKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTV
                     KFDGRSEQQILDIENHTQAVKILLDDLIRFDIIKAYDEITGVGHRVVAGGEYFKESTV
                     VEGDVLEKVEELSLLAPLHNPANAAGVRAFKELLPDITSVVVFDTSFHTSMPEKAYRY
                     PLPTKYYTENKVRKYGAHGTSHQFVAGEAAKLLGRPLEDLKLITCHIGNGGSITAVKA
                     GKSVDTSMGFTPLGGIMMGTRTGDIDPAIIPYLMQYTEDFNTPEDISRVLNRESGLLG
                     VSANSSDMRDIEAAVAEGNHEASLAYEMYVDRIQKHIGQYLAVLNGADAIVFTAGVGE
                     NAESFRRDVISGISWFGCDVDDEKNVFGVTGDISTEAAKIRVLVIPTDEELVIARDVE
                     RLKK"
     gene            23071..23442
                     /gene="rnpA"
                     /locus_tag="VVO18_000819"
     CDS             23071..23442
                     /gene="rnpA"
                     /locus_tag="VVO18_000819"
                     /EC_number="3.1.26.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000739244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P protein component"
                     /protein_id="HEU5586005.1"
                     /translation="MKKNFRVKREKDFKAIFKEGTSFANRKFVVYQLENQKNHFRVGL
                     SVSKKLGNAVTRNQIKRRIRHIIQNAKGSLVEDVDFVVIARKGVETLGYAEMEKNLLH
                     VLKLSKIYREGNGSEKETKVD"
     gene            23417..24241
                     /locus_tag="VVO18_000820"
     CDS             23417..24241
                     /locus_tag="VVO18_000820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein insertase YidC"
                     /protein_id="HEU5586006.1"
                     /translation="MKKKLKLTSLLGLSLLIMTACATNGVTSDITAESADFWSKLVYF
                     FAEIIRFLSFDISIGVGIILFTVLIRTVLLPVFQVQMVASRKMQEAQPRIKALREQYP
                     GRDMESRTKLEQEMRKVFKEMGVRQSDSLWPILIQMPVILALFQALSRVDFLKTGHFL
                     WINLGSVDTTLVLPILAAVFTFLSTWLSNKALSERNGATTAMMYGIPVLIFIFAVYAP
                     GGVALYWTVSNAYQVLQTYFLNNPFKIIAEREAVVQAQKDLENRKRKAKKKAQKTK"
     gene            24260..25246
                     /locus_tag="VVO18_000821"
     CDS             24260..25246
                     /locus_tag="VVO18_000821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398435.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein jag"
                     /protein_id="HEU5586007.1"
                     /translation="MVVFTGSTVEEAIQKGLKELDIPRMKAHIKVISREKKGFLGLFG
                     KKPAQVDIEAISETTVVKANQQVVKGVPKKINDLNEPVKTVSEETVDLGHVVDAIKKI
                     EEEGQGISDEVKAEILKHERHASTILEETGHIEILNELQIEEAMREEAGADDLETEQD
                     QTESQELEDLGLKVETNFDIEQVATEVMAYVQTIIDDMDVEATLSNDYNRRSINLQID
                     TNEPGRIIGYHGKVLKALQLLAQNYLYNRYSRTFYVTINVNDYVEHRAEVLQTYAQKL
                     ATRVLEEGRNHKTDPMSNSERKIIHRIISRMDGVTSYSEGDEPNRYVVVDTE"
     gene            25297..25920
                     /locus_tag="VVO18_000822"
     CDS             25297..25920
                     /locus_tag="VVO18_000822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease P"
                     /protein_id="HEU5586008.1"
                     /translation="MLNKIRDYLDFAGLQYRNPDKAGAEREKMLAFRHKGQEARKAFT
                     ELAKAFQASHPEWQLQQTSQWMNQAQRLRPHFWVYLQRDGQVTEPMIALRLYGNPSDF
                     GISLEVSFIERKKDEQTLGKQAKVLEIPTVKGIYYLTYSNGQSQRWEANEEKRRTLRE
                     KVRSQEVRKVLVKVDVPMTENSSEEEIVEGLLKSYSKILPYYQVTRG"
     gene            26049..27506
                     /locus_tag="VVO18_000823"
     CDS             26049..27506
                     /locus_tag="VVO18_000823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS ascorbate transporter subunit IIC"
                     /protein_id="HEU5586009.1"
                     /translation="MEVVSNVLNWFSSNILQNPAFFVGLLVLIGYALLKKPAHDVFSG
                     FVKATVGYMLLNVGAGGLVTTFRPILAALNYKFQIGAAVIDPYFGLAAANNKIAAEFP
                     DFVGTATTALLIGFGINILLVALRKITKVRTLFITGHIMVQQAATVSLMVLFLVPQLR
                     NAYGTAAIGIICGLYWAVSSNMTVEATQRLTGGGGFAIGHQQQFAIWFVDKVAGRFGK
                     KEESLDNLKLPKFLSIFHDTVVASATLMLVFFGAILLILGPDIMSNKEVITSGTLFNP
                     AKQDFFMYIIQTAFTFSVYLFVLMQGVRMFVSELTNAFQGISNKLLPGSFPAVDVAAS
                     YGFGSPNAVLSGFTFGLIGQLIIIVLLIVFKNPILIITGFVPVFFDNAAIAVYADKRG
                     GWKAAVILSFISGVLQVALGALCVALLDLAAYGGYHGNIDFEFPWLGFGYIFKYLGIV
                     GYVLVCLFLLVIPQLQFAKAKDKEKYYNGEVQEEA"
     gene            27529..27810
                     /locus_tag="VVO18_000824"
     CDS             27529..27810
                     /locus_tag="VVO18_000824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5586010.1"
                     /translation="MVKVLAACGNGMGSSMVIKMKVENALRKLNQRDFTVNSCSVGEA
                     KGLAVGYDIVIASLHLIQELEGRTNGKLIGLDNLMDDKEITEKLSQALQ"
     gene            27886..28371
                     /locus_tag="VVO18_000825"
     CDS             27886..28371
                     /locus_tag="VVO18_000825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5586011.1"
                     /translation="MNLKQALIDNDSIRLGLEANNWKEAVKVAVDPLIESGAILPEYY
                     DAIIESTEEYGPYYILMPGMAMPHARPEAGVQSDAFSLITLQNPVVFSDGKEVSVLLA
                     LAATSSKIHTSVAIPQIIALFELEDSIARLQACQTKEDVLAMIEESKDSPYLEGLDLE
                     S"
     gene            28388..29053
                     /locus_tag="VVO18_000826"
     CDS             28388..29053
                     /locus_tag="VVO18_000826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-keto-L-gulonate-6-phosphate decarboxylase
                     UlaD"
                     /protein_id="HEU5586012.1"
                     /translation="MTKRIPNLQVALDHSDLQGAIKAAVSVGQEVDIIEAGTVCLLQV
                     GSELAEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICCATIPTMEAALK
                     AIKTERGERGEIQIELYGDWTFEQAQLWLDAGISQAIYHQSRDALLAGETWGEKDLNK
                     VKKLIDMGFRVSVTGGLDVDTLKLFEGVDVFTFIAGRGITEAADPAGAARAFKDEIKR
                     IWG"
     gene            29057..29920
                     /locus_tag="VVO18_000827"
     CDS             29057..29920
                     /locus_tag="VVO18_000827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000252119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 3-epimerase"
                     /protein_id="HEU5586013.1"
                     /translation="MVRPIGIYEKATPTHFTWLERLNFAKELGFDFVEMSIDERDERL
                     ARLDWSKEERLEVVKAIYGTGVRIPSICFSGHRRYPLGSKDPVLEEKSLELMKKCIEL
                     AQDLGVRTIQLAGYDVYYEEKSPQTRQRFIKNLRKACDWAEEAQVVLAIEIMDDPFIN
                     SIEKYLAIEKEIDSPFLFVYPDIGNVSAWHNDIYSEFYLGHHAIAALHLKDTYAVTES
                     SKGQFRDVPFGQGCVKWEEAFDILKETNYNGPFLIEMWSENCETVEETRAAIQEAQAF
                     LYPLIKKAGLM"
     gene            29922..30626
                     /locus_tag="VVO18_000828"
     CDS             29922..30626
                     /locus_tag="VVO18_000828"
                     /EC_number="5.1.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001077552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ribulose-5-phosphate 4-epimerase"
                     /protein_id="HEU5586014.1"
                     /translation="MNQVINAMRKRVCDANQSLPKHGLVKFTWGNVSEVNRELGVIVI
                     KPSGVDYDELTPENMVVTDLDGKILEGDLRPSSDLPTHVQLYKAWSEIGSVVHTHSTE
                     AVGWAQAGRDIPFYGTTHADYFYGSIPCARSLTKDEVEVAYEKDTGLVIVEEFEHRGL
                     NPVEVPGIVVRNHGPFTWGKNPENAVYHSVVLEEVSKMNRFTEQINPRVGPAPQYILE
                     KHYQRKHGPNAYYGQK"
     gene            30807..32480
                     /locus_tag="VVO18_000829"
     CDS             30807..32480
                     /locus_tag="VVO18_000829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEU5586015.1"
                     /translation="MVLDKASCDLLQYLMDQETSKTIMAISKDLKESRRKIYYHIDKI
                     NAALGDEALHIISIPRIGIHLTEEQRDACCKLLSEVDSYDYIMSAHERMMIMLLWIGI
                     SKERITIEKLIELTEVSRNTVLNDLNSIRYQLTLEQYQVTLQVSKSQGYHLHAHPLNK
                     IQYLQSLLYHIFMEENATFVSILEDKMKERLDDECLLSVEMNQFFKEQVPLVEQDLGK
                     KINHHEITFMLQVLPYLLLSCHNVEQYQERHQDIEKEFSLIRKRIEYQVSKKLGERLF
                     QKFEISLSGLEVSLVAVLLLSYRKDLDIHAESDDFRQLKLALEEFIWYFESQIRMEIE
                     NKDDLLRNLMIHCKALLFRKTYGIFSKNPLTKQIRSKYGELFLVTRKSAEILEGAWFI
                     RLTDDDIAYLTIHIGGFLKYTPSSQKNMKKVYLVCDEGVAVSRLLLKQCKLYFPNEQI
                     DTVFTTEQFKSVEDIAQVDVVITTNDDLDSRFPILRVNPILEAEDILKMLDYLKHNIF
                     RNKSKSFSENLSSLISSYIVDSKLASKFQEEVQTLINQEIVVQAFLEDI"
     gene            32592..33683
                     /gene="ulaG"
                     /locus_tag="VVO18_000830"
     CDS             32592..33683
                     /gene="ulaG"
                     /locus_tag="VVO18_000830"
                     /EC_number="3.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-ascorbate 6-phosphate lactonase"
                     /protein_id="HEU5586016.1"
                     /translation="MPNVKEITRESWILATFPEWGTWLNEEIEEEVVPEGNFAMWWLG
                     NCGTWIKTPAGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRVQPMVI
                     DPFAINELDYYLVSHFHSDHIDPYTAAAILNNPKLEHVKFIGPYHCGRIWEGWGVPKE
                     RIIVVKPGDTIELKDMKIHAVESFDRTCLVTLPVNGADETGGELAGLAVTDEEMAQKA
                     VNYIFETPGGTIYHGADSHFSNYFAKHGKDFKIDVALNNYGENPVGIQDKMTSIDLLR
                     MAENLRTKVIIPVHYDIWSNFMASTNEILELWKMRKDRLQYDFHPFIWEVGGKYTYPQ
                     DQHLVEYHHPRGFDDCFEQDSNIQFKALL"
     gene            33797..35773
                     /gene="tkt"
                     /locus_tag="VVO18_000831"
     CDS             33797..35773
                     /gene="tkt"
                     /locus_tag="VVO18_000831"
                     /EC_number="2.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185329.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transketolase"
                     /protein_id="HEU5586017.1"
                     /translation="MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLH
                     INPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMDEIKSFRQWGSKTPGHPEF
                     GHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEG
                     VSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGT
                     DLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALG
                     WDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEAHPELAAEVEAIIDGRDP
                     VEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQ
                     DDTNRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGL
                     PVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAWYLAVTSEK
                     TPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVSAAKEL
                     ASQGEKIRVVSMPSTDVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAV
                     LGIDTFGASAPAPKVLAEYGFTVENLVKVVRNLK"
     gene            35890..36189
                     /gene="yajC"
                     /locus_tag="VVO18_000832"
     CDS             35890..36189
                     /gene="yajC"
                     /locus_tag="VVO18_000832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEU5586018.1"
                     /translation="MNPNITFLIMLVGMMALMFFMQRSQKKQAQKRMESLNKLQKGYE
                     VITIGGLYGTVDEVDTEKGTIVLDVDGVYLTFELAAIKTVLPLKETASLEGAIEK"
     gene            36235..36663
                     /locus_tag="VVO18_000833"
     CDS             36235..36663
                     /locus_tag="VVO18_000833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000737444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase"
                     /protein_id="HEU5586019.1"
                     /translation="MKKLVFVCLGNICRSPMAEFVMKSMTDNYEIQSRATSSWEHGNP
                     IHKGTQGIFQEYEIPYDKNKTSLQISKEDFEAFDYIIGMDASNISDLRQMCPVDCQDK
                     IYSFSSESVPDPWYTGDFEETYRRVQEGCQAWLERLEKES"
     gene            36665..37075
                     /locus_tag="VVO18_000834"
     CDS             36665..37075
                     /locus_tag="VVO18_000834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427064.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586020.1"
                     /translation="MENLTNFYEKYRVYLTRPRLELLAVVTIVFCAVLVFFLNIPGKG
                     VLKLDNGTIVYDGSLVRGKMNGQGTITFQNGDQYTGGFNNGAFNGKGTFQSKEGWTYE
                     GDFVNGQAEGKGKLTTEQEVVYEGTFKQGVFQQK"
     gene            37375..40026
                     /gene="adhE"
                     /locus_tag="VVO18_000835"
                     /gene_synonym="adhC"
     CDS             37375..40026
                     /gene="adhE"
                     /locus_tag="VVO18_000835"
                     /gene_synonym="adhC"
                     /EC_number="1.1.1.1"
                     /EC_number="1.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional acetaldehyde-CoA/alcohol
                     dehydrogenase"
                     /protein_id="HEU5586021.1"
                     /translation="MADKKTVTPEEKKLVAEKHVDELVQKALVALEEMRKLDQEQVDY
                     IVAKASVAALDAHGELALHAFEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEE
                     DDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIVFAFHPSAQESSAHA
                     ARIVRDAAIAAGAPENCVQWITQPSMEATSALMNHEGVATILATGGNAMVKAAYSCGK
                     PALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYDEFVAE
                     FKSYHTYFVNKKEKALLEEFCFGVKANSKNCAGAKLNADIVGKQATWIAEQAGFTVPE
                     GTNILAAECKEVGENEPLTREKLSPVIAVLKSESREDGITKARQMVEFNGLGHSAAIH
                     TADEELTKEFGKAVKAIRVICNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVS
                     AINLLNIKKVGRRRNNMQWMKLPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGF
                     LDRIIEQLDLRRNKVVYQIFADVEPDPDITTVNRGTEIMRAFKPDTIIALGGGSPMDA
                     AKVMWLFYEQPEVDFRDLVQKFMDIRKRAFKFPLLGKKTKFIAIPTTSGTGSEVTPFA
                     VISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFVAADTGMDVLTHATEAYVSQMA
                     SDYTDGLALQAIKLVFENLESSVKNADFHSREKMHNASTIAGMAFANAFLGISHSMAH
                     KIGAQFHTIHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIARMLGLPA
                     STPEEGVESYAKAVYELGERIGIQMNFRDQGIDEKEWKEHSRELAFLAYEDQCSPANP
                     RLPMVDHMQEIIEDAYYGYKERPGRRK"
BASE COUNT        12218 a         7228 c         9088 g        11779 t
ORIGIN      
        1 tttagcgggt gtagtttagt ggtaaaacta cagccttcca agctgttgtc gcgagttcga
       61 ttctcgtcac ccgctttgaa ctttgttctt tgtaccaagt ttttgacttg ggcgcgtagc
      121 tcaggtggtt agagcgcacg cctgataagc gtgaggtcgg tggttcgagt ccactcgtgc
      181 ccatagtgtt tagtccatta ctaggggatt ggaatattat ctgttcacta agaggacacg
      241 ggcttgttcc cgtataaact attttggagg attacccaag tccggctgaa gggaacggtc
      301 ttgaaaaccg tcaggcgtgt aaaagcgtgc gtgggttcga atcccacatc ctccttttat
      361 attaacgcgg gatggagcag ctcggtagct cgtcgggctc ataacccgaa ggtcgtaggt
      421 tcaaatcctg ctcccgcaat aaggctcggt agctcagttg gtagagcaat ggattgaagc
      481 tccatgtgtc ggcggttcga ttccgtctcg cgccatttat atattttgga agggtagcga
      541 agaggctaaa cgcggcggac tgtaaatccg ctccttcggg ttcgggggtt cgaatccctc
      601 cccttccatt ttacgggcat agtttaaagg tagaactaag gtctccaaaa ccttcagtgt
      661 gggttcaatt cctactgccc gtgttaatag aattatggcg ggtgtggtga agtggttaac
      721 acaccagatt gtggctctgg catgcgtggg ttcgatcccc atcactcgcc tattttatat
      781 tggggtatag ccaagcggta aggcaaggga ctttgactcc ctcatgcgtt ggttcgaatc
      841 cagctacccc agttactatt tgccggcgtg gcggaattgg cagacgcgct ggactcaaaa
      901 tccagtgtcc gcaaggacgt gccggttcga ccccggccgc cggtatagta tagtgttagg
      961 aacgttgtta ttcttcgttc cttttttata ttatttttgg tataattata gttattcaaa
     1021 ttttatttag attaagaaag tgtagggtag tatgtcttgt tctatcgatt tattaaaaca
     1081 tcggtatttg aaaaatatta aagaaaatcc tgaattgttt gtcggaattg agttggagta
     1141 tcctgttgca agtttagaag gggatgctac agatgttgaa gttataaagg atctatttca
     1201 ttatttagtt tctactttgg atctcaccgt agcaaaggta gatgattttg gcaatctgat
     1261 ccagttagta gatccgataa gtcaggatgc tattttattt gaagtttcct atacaacgat
     1321 tgagtttgca tttggtaagg ctgaaacgat tcaagaggtc gaaaatcgtt tcaataatta
     1381 tatgaatgta attcagagaa agttagctga atcaaatcat gctattgttg gctgtggtat
     1441 ccatcccaac tgggataaaa atgagaattg tccagtggct tatccacgct atcagatgtt
     1501 gatggattat ttgaatttga gtagaaatat tattaaatca gatttacatc atttccctga
     1561 atatggtact tttatctgtg ggagccaggt tcagctggat atttcaaaaa ccaactactt
     1621 acgggtgatt aatgctttta ctcaaattga agcggctaag gcttatttct ttgcaaactc
     1681 tgaattttcg ggtgcggatt gggatacgaa aatttcaagg gatattttct gggaagaatc
     1741 tatgcatggt atctatccag agaatgttgg ggtcaatgct agactcctta atgatgaagc
     1801 tgattttttt gactatctaa atcattctgc gatttttact gcggaacgtg atgggcagac
     1861 ctattatttt tatcctattc aggctgggga ctatttggct acgcctgaaa tccaagcatt
     1921 tgctctgaat ggggatgagg ttattatttc cccccaagag aaggattttg aaactcatcg
     1981 tagttaccag taccaagact taacgactcg aggaacagtt gagtttcgta gtgtgtgtac
     2041 acagccactt gataggactt ttgcttctgc agcttttcac ttgggattat tggttaattt
     2101 agacaagtta gaagcttact tagaaacagc acctttcttt aaagtatttg gttatgatta
     2161 caagtcttta aggagacaat tttctaagaa aaatcttaca gatgaggaag aaactacgat
     2221 tattgaattt tccaaagact tactcctact agctgaggag ggactagtgg tgagaaataa
     2281 ggaagaaatg acctatttac agcctttgag agaagaattg agcctataat ttctcttata
     2341 aagggagaat tttctgaaaa atcatgatat aatggacgag actatagata aaggatagag
     2401 agtaatgaca ttagtttatc aatcaacgcg tgatgccaac aatacagtaa ctgctagcca
     2461 agcaattttg caaggtttgg cgacggacgg cggtttgttt acaccggtta cttatccaaa
     2521 ggtagatttg gactttgaca aattgaaaga tacttcttac caggaagttg ctaagctagt
     2581 tttgtcagca tttttagatg actttacagc tgaggagttg gactactgta tcaacaatgc
     2641 ctacgatagc aaatttgata ctccagctat tgcaccatta gtgaaattag atgggcaata
     2701 caatttggaa cttttccatg gttcaacgat tgcctttaag gatatggcct tgtctatttt
     2761 gccatacttt atgacgactg ctgctaagaa acatggtttg gagaacaaga ttgttatctt
     2821 gacagcaaca tctggtgaca cggggaaagc tgctatggcg gggtttgcgg atgtgcctgg
     2881 tactgagatt atcgtctttt atccaaagga tggtgtcagc aagattcaag agttacaaat
     2941 gaccactcaa actggcgaca atactcatgt tattgctatt gatggtaact ttgacgatgc
     3001 gcaaacaaat gtgaagcaca tgtttaacga cgtggctctt cgtgaaaaat tgactaccaa
     3061 caagttgcaa ttttcatcag ctaactctat gaacattggt cgtctggtgc cacaaattgt
     3121 ttattatgtt tatgcttacg ctcaattggt caagactggt gagatcgtgg ctggtgataa
     3181 gattaacttc acagtaccaa caggaaactt tggaaatatc ttggctgcct tttatgccaa
     3241 acaaatcggt ctcccagttg gtaaattgat ctgtgcttca aatgacaaca atgttttgac
     3301 agacttcttc aagacacgtg tttacgacaa gaaacgtgag tttaaggtaa caaccagccc
     3361 atctatggat atcttggtat cttcaaactt ggagcgcttg attttccatc ttttgggaaa
     3421 taatgctgaa aagacagttg aacttatgaa tgccttgaac acgcaaggac aatataagtt
     3481 gacagacttt gatgcagaga ttttggacct ctttgcagct gaatatgcga ctgaggaaga
     3541 aacggcagca gagatcaagc gtgtttgtga gttagattct tatatcgagg accctcatac
     3601 agctgttgct tcagcagttt ataaaaaata ccaatcggcc actggagatg taactaagac
     3661 agtgattgct tcaacagcta gtccatacaa gttcccagta gttgcagtag aagctgtaac
     3721 tggaaaagca ggtttaacag actttgaagc cttggctcaa ttacatgaaa tctcaggcgt
     3781 tgcagtgcca ccagcagttg atgggcttga aatatctcca attcgtcaca agacaacagt
     3841 ggcagctgct gacatgcaag cagcggttga ggcttattta ggactttaag acagagggag
     3901 caaactcggt tgggaaacca actgagtttc ttttcatcag gaggagagat tgtttaagaa
     3961 aaataaagac attcttaata ttgcattgcc agctatgggt gaaaactttt tgcagatgct
     4021 aatgggaatg gtggacagtt atttggttgc tcatttagga ttgatagcta tttcaggggt
     4081 ttcagtagct ggtaatatta tcaccattta tcaggcgatt ttcatcgctc tgggagctgc
     4141 tatttccagt gttatttcaa aaagcatagg gcagaaagac cagtcgaagt tggcctatca
     4201 tgtgactgag gcgttgaaga ttaccttact attaagtttc cttttaggat ttttgtccat
     4261 cttcgctggg aaagagatga taggactttt ggggacggag agggatgtag ctgagagtgg
     4321 tggactgtat ctatctttgg taggcggatc gattgttctc ttaggtttaa tgactagtct
     4381 gggagccttg attcgtgcaa cgcataatcc acgtttgcct ctctatgtta gttttttatc
     4441 caatgccttg aatattcttt tttcaagtct agctattttt gttctggata tggggatagc
     4501 tggtgttgct tgggggacaa ttctgtctcg tttggttggt cttgtgattt tgtggtcaca
     4561 attaaaactg ccttatggga agccaacttt tggtttagat aaggaactgt tgaccttggc
     4621 tttaccagca gctggagagc gacttatgat gagggctgga gatgtagtga tcattgcctt
     4681 ggtcgtttct tttgggacgg aggcagttgc tgggaatgca atcggagaag tcttgaccca
     4741 gtttaactat atgcctgcct ttggcgtcgc tacggcaacg gtcatgctgt tggcccgagc
     4801 agttggagag gatgattgga aaagagtcgc tagtttgagt aaacaaacct tttggctttc
     4861 tctgttcctc atgttgcccc tgtcctttag tatatatgtc ttgggtgtac cattaactca
     4921 tctctatacg actgattctc tagcggtgga ggctagtgtt ctagtgacac tgttttcact
     4981 acttggaacc cctatgacga caggaacagt catctatacg gcagtctggc agggattagg
     5041 aaatgcacgc ctcccttttt atgcgacaag tataggcatg tggtgtatcc gcattggaac
     5101 aggatatctg ctggggattg tgcttggttg gggcttgcct ggtatttggg cagggtctct
     5161 cttggataat ggttttcgct ggttatttct acgctatcgt taccagcgct atatgagctt
     5221 gaaaggatag gaaatgcaaa aaacagcttt tatttgggat ttagacggga ctttattgga
     5281 ctcttacgaa gcgattttat cagggattga ggagactttt gctcagtttt ctattcctta
     5341 tgataaggag aaggtgagag agtttatctt caagtattcg gtgcaagatt tgcttgtgcg
     5401 ggtggcagaa gatagaaatc tggatgttga ggtgctaaat caggtgcgtg cccagagtct
     5461 ggctgagaag aatgctcagg tagttttgat gccaggtgcg cgtgaggtgc tagcttgggc
     5521 agacgaatca ggaattcagc agtttatata tactcataag gggaacaacg cttttaccat
     5581 tctcaaggac ttgggggtgg aatcctattt tacagagatt ttaaccagtc agagtgactt
     5641 tgtgcggaag ccaagtccag aagcggctac ctatctgcta gataagtatc agttgaattc
     5701 tgataatact tattatatag gggatcggac tctggatgtg gaatttgccc agaatagtgg
     5761 gattcaaagt atcaactttt tagagtctac ttatgaaggg aatcacagga ttcaagcgtt
     5821 agcagatatt tcccgtattt ttgagactaa gtgataaaaa gattgtgtca gttttgtgac
     5881 agagacctaa caaactattt caagtaacct agtttgttac aaggaataga cagttctgtt
     5941 aaataggccc gagagggctt tttttctaca ttttttgtgt tatgatagac aggtactcat
     6001 ttgaaaggaa tttgaaagaa tgaagaaaag aatgttatta gcgtcaacag tagccttgtc
     6061 atttgcccca gtattggcaa ctcaagcaga agaagttctt tggactgcac gtagtgttga
     6121 gcaaatccaa aacgatttga ctaaaacgga caacaaaaca agttataccg tacagtatgg
     6181 tgataccttg agcactattg cagaagcctt gggtgtagat gtcacagtgc ttgcgaatct
     6241 gaacaaaatc actaatatgg acttgatttt cccagaaact gttttgacaa cgactgtcaa
     6301 tgaagcagaa gaagtaacag aagttgaaat ccaaacacct caagcagact ctagtgaaga
     6361 agtgacaact gcgacagcag atttgaccac taatcaagtg atcgttgatg atcaaactgt
     6421 tcaggttgca gacctttctc aaccaattgc agaagctcca aaagaagtag catcaagttc
     6481 agaagttaca aagacagtga ttgcttctga agaagtggca ccatctacgg gcacttctgt
     6541 cccagaggag caaacggccg aaacaagcag tgcagttgca gaagaagctc ctcaggaaac
     6601 gactccagct gagaagcagg aaacacaagc aagccctcaa gctgcatcag cagtggaagt
     6661 aactacaaca agttcagaag caaaagaagt agcatcatca aatggagcta cagcagcagt
     6721 ttctacttat caaccagaag agacgaaaat aatttcaaca acttacgagg ctccagctgc
     6781 gcccgattat gctggacttg cagtagcaaa atctgaaaat gcaggtcttc aaccacaaac
     6841 agctgccttt aaagaagaaa ttgctaactt gtttggcatt acatccttta gtggttatcg
     6901 tccaggagac agtggagatc acggaaaagg tttggctatc gactttatgg taccagaacg
     6961 ttcagaatta ggggataaga ttgcggaata tgctattcaa aatatggcca gccgtggcat
     7021 tagttacatc atctggaaac aacgtttcta tgctccattc gatagcaaat atgggccagc
     7081 taacacttgg aacccaatgc cagaccgtgg tagtgtgaca gaaaatcact atgatcacgt
     7141 tcacgtttca atgaatggat aaacccgact tgataacatc attttgacga atgagatcta
     7201 gctttcgtga tggcaagcga ttctcgttcg ttttttcttt gtcatactct tcgaaaatct
     7261 cttcaaacca cgtcagtttt atctgaaact tcaaagctgt gctttgagca acctgcgact
     7321 agcttcctag tttgcttttt gattttcatt gagtatcaat ttgaatggaa aatggaaagt
     7381 tatcatcttg taatgagtta agcaacattc ttgcaatcta ttttacttta tatcacaatt
     7441 aattagtcaa atattgataa atcaataaaa agagagggga agaaatgcta gagattcaag
     7501 atttactgta tcaactccgc ttgtctgagc aagcgagtac gcaattgttt gaaaaaaggc
     7561 ttgggattag tttgacacgg tatcagattt tactgttttt gctggagcat tctccttgta
     7621 accaaatggc gattcaggag cgtttgaaaa ttgatcaggc tgctttgaca cggcatttca
     7681 agattttgga aacggaaggt ttggtggagc gtcatcgtaa tcctgaaaat cagcgggaag
     7741 tgttggtaga ggctgcgaag tatgccaagg agcagttagt ggtgaatccc cctctgcaac
     7801 atatcaaggt taaggaagag atggaaagta tcttaacaga gtttgagaga acagaactca
     7861 gccgtttatt aaataaattg gttttgggta ttgaaaatat agaaatttaa ggagaaatag
     7921 atgtcaatta ttacaattat tttaacaacg atcgttgctt tggagcattt ttacattttt
     7981 tatttggaaa gtattgctac gcgatcagat gcgactagtc gtgtatttaa tatggaaaag
     8041 gaagaattgg ctcatccgtc agtaagttca ttgttcaaaa atcaagggat ttataaggct
     8101 ctgctaggag tctttctctg gtatggcatt tatttctcac agaatttaga aattgtgact
     8161 atttttgtct tatttgtgat tggtgctgcg acttacggct ctttaacagc ggataaaaaa
     8221 attattttga agcaaggtgg atcagctatt ttggccttga ttagtatttt actctttaaa
     8281 atacacttga aggtcgattc taatctcgct aatccttttt aatccagaat aagggaaata
     8341 tgttatactt gtttttaaga aaaaagtctc attgaattgg ttttgaggag ttagaaatga
     8401 aagtattagt gacaggtttt gagccctttg gaggggaaaa gggcaatcca actttggagg
     8461 ccattaaagg tttaccagct gaaatccatg gtgctgaggt ccgttggcta gaggtgccga
     8521 cagtttttca caaatctgct caagtattgg aagaagagat gaatcgttat caacctgact
     8581 ttgtcctttg tattgggcaa gctggtggaa gaactagtgt gacacctgaa cgagtggcca
     8641 ttaatcaaga cgatgcacgc atttctgata acgaagataa tcaaccgatt gaccgtccca
     8701 ttcgcccaga tggtgcttcg gcctacttta gtagtttgcc gattaaagcg atggttcaag
     8761 ctataaaaaa agagggctta ccggcctctg tttccaatac ggcagggact tttgtctgca
     8821 gccatttgat gtatcaggct ctctatttgg tagaaaagaa atttccatat gttaaggcag
     8881 gttttatgca tattccttat atgatggaac aggtggtgaa cagaccgact actccaacta
     8941 tgagtttagt ggatattcgg cgagggatag aagcagcaat cggcgctatg atagaacatg
     9001 gagatcagga actcaagttg gtaggcggag aaactcattg atagaaaaaa gcttgagggg
     9061 aaaaaccttc aagcttttgg acgttttcga gccaatactg ctcggtaaaa cataatttta
     9121 gtgcattgga tataaggtag gagtgaaaaa ctagcaatgc caaaggtaat ccaattgagg
     9181 aagtaccaag gaagaagctg taaatctagg acaaagtgct ggaacttgta gcccttcata
     9241 aaggaacggc tagtttttag gattcgtctt ggtgggacct gtcctaggtc tagactataa
     9301 cagagaagaa attccacctg tgaataggca taatactgtg gaatatagag gatatttcct
     9361 acaatgatca agatgagact tgcaagaaag tagagtccaa agaccatgag gaaacgctcg
     9421 gtttcaactg atgagagatc tagatttgga aactcaggat gtagggtgac gaattttttg
     9481 gctaaaaagc tactataaaa gaggagataa atcccaagta aattagggat actccataaa
     9541 aagagataga aacgtttgag aagtagggtc aaaaaggttt gagaaaagcg ctcctcatca
     9601 aagagagcta ggctgttttt tacagatggc tccgttttag aatctttcat gagtgtcagt
     9661 gttgcataga cggaactggt caaaagaata gtcccgataa aggagactag tagaggaaag
     9721 aggtaggctt gaagtatttg gccaagtatg ctgaaaaatg gctgttctaa aacagtcccg
     9781 tggatccgag ataagggatt aagaaaacta gataagatga ccagcatact gggaaggata
     9841 tagaggagaa agagacgggg ggtgtcagcc tgaaaatgtt ttgactcctg acgaattgtt
     9901 tttaaatcaa tttttggata gttcattctc ttattatacc atagttctta tacatagttc
     9961 gtgacagttc ctactttttt tgataaaatc atacagtgtg tccttgggca cactgtatga
    10021 actgggactg tctttcccag cttcggaggt aaaaaatgtc agattcacca atcaaatatc
    10081 gtttgattaa gaaagaaaaa cacacaggag ctcgtctagg agaaatcatc actccccacg
    10141 gtacctttcc gacacctatg tttatgccag ttgggacaca agccactgtc aaaactcagt
    10201 cacctgaaga attgaaggag atgggttcgg gaattatcct atcaaacact tatcatctct
    10261 ggcttcgccc tggagatgaa ctcattgcac gcgctggtgg tctccacaag ttcatgaatt
    10321 gggaccagcc tatcttgaca gatagtggtg gttttcaggt ttattcttta gcagatagcc
    10381 gtaatatcac agaagaagga gtaaccttta aaaatcatct aaatggttct aagatgttcc
    10441 tatccccaga aaaagccatc tctattcaga ataatctggg ttcagacatc atgatgtcct
    10501 ttgatgaatg tcctcagttt tatcaacctt atgactacgt taagaaatcg atcgagcgta
    10561 ccagccgttg ggctgagcgt ggtttgaagg ctcaccgtcg tccacatgac caaggtttgt
    10621 ttggaattgt gcaaggtgca ggatttgaag accttcgccg ccaatcagct catgatcttg
    10681 tcagcatgga tttctcaggc tactctatcg gtggtttggc agtgggagaa acccatgaag
    10741 agatgaatgc ggtcttggac tttacaactc aactgctgcc tgaaaataaa cctcgttatc
    10801 tgatgggtgt gggagcgcca gatagcttga tcgatggggt cattcgtggg gtggatatgt
    10861 ttgactgtgt cttaccgact cgaattgctc gtaacgggac ttgtatgacc agtcaaggac
    10921 gtttggttgt gaaaaatgcc cagtttgctg aggactttac gccactggat cctgagtgtg
    10981 attgctacac atgtaataac tatacacgcg cttaccttcg tcacctgctc aaggctgatg
    11041 aaacctttgg tatccgcttg actagctacc acaatcttta cttcttgctt aacctgatga
    11101 agcaagtgcg acaagccatc atggatgaca atctcttgga attccgtaaa tattttgtgg
    11161 aaaaatatgg ctataataag tcaggacgta atttctaaaa tggaattaat ataagctaaa
    11221 aatcctaagt tttctcttag gatttttctt ctttttttga tagaataaag tgtacaatga
    11281 aaggaagaat aaactcgtat gcgcattaaa tggttttcct tgattaggat tataggttta
    11341 cttttggtac tcttgtatca cttctttcag acgatctttc ctggaggatt tttcggggta
    11401 gatgtctttt ttacattttc aggtttcctg attacagctc tactcattga agaattttct
    11461 aagaaccatg agattgattt gataggattt tttagaagac gcttttatcg gattgtgcca
    11521 cctgtggttt tgatggtctt ggtgaccatg ccttttactt tcttggttcg ccaagactat
    11581 gttgctggaa ttggtggcca gattgcgggc gtcttaggct ttatgaccaa cttctatgaa
    11641 ctcctaacag gtgggagtta tgaatctcag ttcattcctc atttgtttgt tcataattgg
    11701 agtttggcag ttgaggttca ctactatatt ctttggggat tggcagtttg gttcttatcc
    11761 aaacaagcta aatcaaatgg tcagttgaag gggatggtct ttctcttatc tgctgctgcc
    11821 ttcttgatca gtttcttctc catgtttatt ggtagttttc tagtgacctc ttattcctct
    11881 gtttatttct ccagtttaac tcatgtctat ccattctttt tgggaagtat gttagcaact
    11941 attgtaggcg ttcgtcagac gacttccctc gtcaagcagt tggataaaat ctgggattta
    12001 cgaaagactt tggtagtttt tggaggaggc tttggtttcc tagttctttt gactttcttt
    12061 gtcaaattca cttatctttt tgcctatctt atcggcttct tacttgccag tcttgcagct
    12121 cttgccatga ttctggcggc gcgtgtctta catgaaaaga cacatcatat acaggagccg
    12181 aagattatca gctttttagc ggatactagc tatgcggttt atcttttcca ttggcctttc
    12241 tatatcattt tctcacagtt gacatcaaat cttcttgctg tattactgac tctgatttgt
    12301 tcttatggct ttgccagtct gtcattttat gtattggaac cttggattgc aggcaagaac
    12361 acacctattg tccaaaccct tcgtcccctg ccttatattc acgcaattct tgcagcaggt
    12421 acaggaatct tgaccatcat tgtctgcacg gtgaccttgt tggcaccaca agtgggagcg
    12481 tttgagacag acttgactgt caatggcttg aagcaagctg caacaaatat tggccagacc
    12541 aaggtgatgg cagaacgggc agatgcaaac agtttgggaa ttgctgatgg cactatgtta
    12601 attggtgact cagtggcttt aagggcaaat acagcactac agacagctct tcctggagca
    12661 cagattaacg cgcaggtcag cgtaacaacc aagaccgcaa atgaaatcat gctaaataat
    12721 agccagaata aatttttacc taagacggtg gtcattgcga ctggggtaaa taatcctgag
    12781 aattacaagg atgactggga cagtatcgtg aaaaatcttc ctaagggaca ccatatgatt
    12841 ttggtgactc cttatgaggg agataagaca aaagagacct atgccatcgt tgagaaggct
    12901 gctgcctata tgagagaatt ggcagagaag acaccttaca ttacgatagc agattggaat
    12961 caagttgcga aagagcatcc agaaatttgg gctggaacag accaggttca tttcgggagt
    13021 gagagtagca ctatcgaagc aggagcaaaa ttgtatgcag atacgattgc cacagctttg
    13081 cagacagctc aagacaagcc ggttaaatca aaataacttg tattaaaaaa gagaagagtt
    13141 ggagaaatcc agctctttta aaatatctcc aaaaaatagg tctataccat ttacaaataa
    13201 aaaagaaagg tttataatgt aattgacata ataaattgta gaatcaatct tttaaggagg
    13261 ttaacattat gcctaactat attaaagcgg atcagttttt ctacccacac ggagttcgtc
    13321 gaggtggtta cttggaactt gtggacggca agtttgggaa acatgtagag cagatttctg
    13381 aaggggctga ggtgattgac tatacaggtt atagcattgc cccaggtctt gtggatactc
    13441 atattcatgg atatgcaggt gtagatgtga tggacaacaa cattgaaggt acattgcata
    13501 ctatgagtga aggacttctt agtaccggtg ttaccagttt cttacccaca actttaacag
    13561 ccacttatga gcaattgctt gcagtcactg aaaatcttgg aaaccattat aaagaagcaa
    13621 caggtgctaa gattcgtggg atttattatg aaggtccata tttcacagaa acttttaagg
    13681 gggcacaaaa tccaacttat atgagagacc cgggtgttga ggagtttcat tcttggcaaa
    13741 aagcggcaaa tggcttgctt aataaaattg cccttgcacc agaacgtgat ggggtggaag
    13801 actttgttcg tacagttacg ggcgaaggtg tgacggttgc tcttggacat tcaaacgcga
    13861 cttttgctga agccaaaaaa gcagtcgatg ctggagcgag tgtttgggtg catgcctaca
    13921 atggaatgcg tgggttgact caccgtgaat tgggtatggt tggagccatg taccaattgc
    13981 cacataccta tgcagagttg atctgtgatg gtcaccacgt agatccaaag gcttgcgaaa
    14041 ttcttatcaa acaaaaagga acagaaaaca tcgctcttat cacagactgt atgacagctg
    14101 ggggattgga agacggagat tatatgttgg gagaattccc agttgtcgtt gcaaatggaa
    14161 ctgcacgcct caaatctaca ggtaacttgg caggttctat cctcaaactc aaagatggtt
    14221 tgaagaatgt ggtcgaatgg ggaattgcga atccgcatga agcagtcatg atggccagct
    14281 tcaacccagc taaatccgtt cacatcgatg acgtctgtgg ccaaatccgt gaaggctacg
    14341 acgctgactt catcgtatta gataaagatt tggaattggt agcaacctac ctagatggcg
    14401 taaaacgtta tcaagcataa gagagaaagc agaagttaga gactaacttc tgctttttta
    14461 tgcagggtac tttactggta aataaaaagt taaaaaaatc acaaaaaaag cttgaagaaa
    14521 caaagaaaaa ggcttacaat tgaactataa atattacaaa taaaaaaacg gaggagtgct
    14581 ttatgaaagc ctatacttat gttaaaccag gacttgcttc ttttgttgat gtagacaaac
    14641 cagttattcg caagccaaca gacgctattg tgcgtattgt aaaaaccact atttgtggaa
    14701 cagacctcca tattatcaaa ggggatgttc ctacttgcca aagtggtacc attcttggcc
    14761 acgaagggat tgggattgtt gaagaagttg gggaaggagt ttccaacttc aaaaaaggtg
    14821 acaaggtctt gatttcttgc gtctgtgcct gtggtaaatg ctactactgt aaaaaaggaa
    14881 tttatgctca ctgtgaagac gaagggggct ggattttcgg tcacttgatt gatggtatgc
    14941 aggctgaata tctacgtgtc cctcatgcag ataatactct ttaccatact ccagaagact
    15001 tgtcagatga agctttggtt atgctgtcag acattctgcc tactggatat gaaattggtg
    15061 tcttaaaagg gaaagtagaa cctggttgca gcgtagccat tattggttca ggtccagttg
    15121 gattggctgc tcttttaaca gcccaattct attcaccagc taaattgatt atggtagacc
    15181 tagacgataa ccgcttggaa actgccctat cattcggtgc gactcataag gttaattctt
    15241 cagaccctga aaaagccatt aaagaaattt atgatttgac agatggtcgt ggtgtggatg
    15301 tcgctatcga agctgttggt attcctgcaa catttgattt ctgtcaaaag attatcggtg
    15361 tagacggaac ggttgccaac tgtggtgtgc atggtaaacc agttgaattc gatttagata
    15421 aactttggat tcgcaacatc aatgtaacaa ctggtttggt atctacaaat acgactccac
    15481 aattgttgaa agcgcttgaa agtcataaga ttgaaccaga aaaattggta actcactatt
    15541 tcaaactcag tgaaattgaa aaagcctacg aagtcttcag taaggcagca gaccaccatg
    15601 ccattaaggt cattatcgaa aacgatatct cagaagccta agtagtaaaa atatttttgt
    15661 acataagtaa atagaaattc agtcatccat cagatggctg gattttttat caaaaaatta
    15721 agaaatgagc atatttcttt ccttgtctgg cggaattggt tataatatac ggtacaaagg
    15781 aatgaatgaa tatgtatcgt gttatagaaa tgtacggaga ttttgaaccg tggtggttct
    15841 tagaaggttg ggaagaagat attgtagcaa gtagaaaatt tgaccagtat tatgatgctc
    15901 tcaaatacta caaaacttgc tggtttagat tggaacaaga atcgcctctt tataaaagta
    15961 gaagcgactt gatgaccatt ttttgggacc cggaagacca acgctggtgt gatgaatgtg
    16021 atgagtattt acaacaatac cattctttgg ctcttttgca ggatgagcag gttatcccag
    16081 acgaaaaact acgctcaggc tatgaaaaac aaaccagtca ggaaaggaat cgttcttgcc
    16141 gtatgaaatt aaaatagaga aaagtaactt ttttggagtt gcttttttta tttttctaac
    16201 tctttgcgaa tagtataggt gaggaggtaa gtatggttca agaaattgca caagaaatca
    16261 ttcgctcggc tcggaaaaaa ggggcgcaag acatttattt tgtccctaag ttagacgcct
    16321 atgagcttca tatgagggta ggagacgagc gctgtaaaat tggtagctat gattttgaaa
    16381 agtttgcagc cgttatcagt cactttaagt ttgtggcggg tatgaatgtg ggagaaaaaa
    16441 gacgtagtca actgggttcc tgtgattatg cctatgacca gaagatagcg tctctacgtt
    16501 tatctactgt aggcgattat cgggggcatg agagtttggt tatccgtttg ttgcacgatg
    16561 aggagcagga cctgcatttt tggtttcagg atattgaaga attaggcaag cagtacaggc
    16621 aacgggggct ctatcttttt gctggtccgg ttgggagtgg taagacgacc ttgatgcatg
    16681 aattgtccaa gtcactcttt aaaggacagc aagttatgtc catcgaagat cctgtcgaaa
    16741 tcaagcagga cgacatgctt cagttgcagt tgaacgaagc aatcggccta acctatgaaa
    16801 atctaatcaa actttccttg cgtcatcgac cagatctctt gattatcgga gaaattcgtg
    16861 acagcgagac ggcgcgtgca gtggtcagag ctagtttgac aggtgcgaca gtcttttcaa
    16921 ccattcatgc taagagtatc cgaggtgttt atgagcgtct gctggagttg ggtgtgagtg
    16981 aagaagaatt ggcagttgtt ttgcaaggag tctgctacca gagattaatc gggggaggag
    17041 gaatcgttga ctttgcaaac agagattatc aagaacacca agcagccaag tggaatgagc
    17101 aaattgacca gcttcttaaa gatggacata tcacaagtct tcaggctgag acggaaaaaa
    17161 ttagctacag ctaagcaaaa aaatatcatc accctattta acaatctctt ttctagcggt
    17221 tttcatctgg tggagaccat ctccttttta gataggagtg ctttgttgga caagcagtgt
    17281 gtaacccaga tgcgtgtggg cttgtctcag gggaaatcat tctcagaaat gatggaaagt
    17341 ttgggatgtt caagtgctat tgtcactcag ttatccctag ctgaagttca tggcaatctc
    17401 cacctgagtt tgggaaagat agaagaatat ctggacaatc tggccaaggt caagaaaaaa
    17461 ttaattgaag tagcgaccta tcctttgatt ttgctgtttt ttcttctctt aattatgctg
    17521 gggctacgga attacctgct cccacaactg gatagtagca atattgccac ccgaattatc
    17581 ggtaatctgc cacaaatttt tctaggcatg gtagggcttg tttccgtgct tgccctttta
    17641 gcactaactt tttataaaag aagttctaag atgagtgttt tttctatctt agcacgcctt
    17701 ccctttattg gaatctttgt gcagacctac ttgacagcct attatgcacg tgaatggggg
    17761 aatatgattt cacagggaat ggagctgacg cagatttttc aaatgatgca ggaacaaggt
    17821 tcccagctct ttaaagaaat cggtcaagat ctggctcaaa ccctgaaaaa tggccgtgaa
    17881 ttttctcaga cgataggaac ctatcctttc tttaggaagg aattgagtct catcatagag
    17941 tatggggaag ttaagtccaa gctgggtagt gagttggaaa tctatgctga aaaaacttgg
    18001 gaagcctttt ttacccgagt caaccgcacc atgaatttgg tgcagccact ggtttttatc
    18061 tttgtggcac tgattatcgt tttactttat gcggcaatgc tcatgcccat gtatcaaaat
    18121 atggaggtaa atttttaaaa tgaaaaaaat gatgacattc ttgaaaaaat ctaaggttaa
    18181 agcttttaca ttggtggaga tgttggtggt cttgctgatt atcagcgtgc ttttcttgct
    18241 ctttgtacct aatctgacca agcaaaaaga ggcagtcaat gacaaaggaa aagcagctgt
    18301 tgttaaggtg gtggaaagcc aggcagaact ttatagcttg gaaaagaatg aagatgctag
    18361 cctaagcaag ttacaagcag atgggcgaat cacggaagaa caggctaaag cttataaaga
    18421 ataccatgat aaaaatggag tagcaaatcg taaagtcaat gattaaggcc tttaccatgc
    18481 tggaaagtct cttggctttg agtcttgtga gtatccttgc cttgggcttg tccggctctg
    18541 ttcagtccac ttttgcggca gtagaggaac agattttctt tatggagttt gaagaactct
    18601 atcgggaaac ccaaaaacgc agtgtagcca gtcagcaaaa gactagtctg aacttagatg
    18661 ggcagacgat tagcaatggc agtcaaaagt tgccagtccc taaaggaatt caggccccat
    18721 caggccaaag tattacattt gaccgtgctg ggggcaattc gtccctggct aaggttgaat
    18781 ttcagaccag taaaggagcg attcgctatc aattatatct aggaaatgga aaaattaaac
    18841 gcattaagga aacaaaaaat tagggcagtg attttactgg aagcagtagt cgctctagct
    18901 atctttgcca gcattgcgac cctccttttg ggacaaattc aaaaaaatag gcaagaggaa
    18961 gcaaaaatct tgcaaaagga agaagtcttg agggtagcta agatggcctt gcagacaggt
    19021 caaaatcagg taaacataaa cggagttgag attcaggtgt tttctagcga aaagggattg
    19081 gaggtctacc atggttcaga acagttgttg gcaatcaaag agccataagg tcaaggcttt
    19141 taccttgtta gaatccctgc ttgccctgct cgtcatcagt ggaggcttac tcctttttca
    19201 agctatgagt cagctcctca tttcagaagt tcgctaccag caacaaagcg agcaaaagga
    19261 gtggctcttg tttgtggatc aacttgaggc agaattagac cgttcgcagt tcgaaaaagt
    19321 ggaaggcaat cgtttctata tgaagcaaga tggcaaggac atcgccatcg gtaagtcaaa
    19381 gtcagacgat tttcgtaaaa ccgatgctag tggacggggg tatcagccta tggtttatgg
    19441 cctcaaatca gctcagatta cagaggacaa tcaactggtt cattttcgtt tccagtttca
    19501 aaaaggctta gaaagggagt tcatctatcg tgtggaaaaa gaagaaagtt aaggcaggtg
    19561 ttctcctcta tgcagtcacc atggcagcta tctttagtct tttgttgcaa ttttacttga
    19621 accgacaagt cgcccactat caagactatg ctttgaataa agaaaaattg gttgcttttg
    19681 ccatggctaa acgaaccaag gataaagccg agcaagaaag tggggaacag gtctttaatc
    19741 taggtcaggt aagctatcaa aacaagaaaa caagcttggt gacgactgtt cgtacggata
    19801 agagtcaata tgagtttctg tttccttcag tcaaaatcaa agaagagaaa agagataaaa
    19861 aggaagaggt agcgactgat tcaagcgaaa aagcggagaa gaaaaaatca gaagagaagc
    19921 ctgaaaagaa agagaattcc tagtcaattc aactataatg cgttgaatcc agaatagtcc
    19981 actgtagttt ctagaaaatt gctggaaatg gatgttaagc tccaattcat ttgtttatat
    20041 cttatttcag tttactatac tttgtgctaa actaaagata tgaaacatga ttttaaccac
    20101 aaagcagaaa ctttcgattc ccctaaaaat atcttcctcg caaacttggt atgtcaagca
    20161 gtcgagaaac agattgatat tttatcagac aaagaaattt tagatttcgg tggtggcacg
    20221 ggtctattag ccttgcccct agccaagcag gctaagtcag ttactcttgt agacatttct
    20281 gagaaaatgt tggagcaagc tcgtttgaaa gcggagcagc aagcaatcaa gaatatccag
    20341 tttttggagc aagatttacc gaaaaatccc ttggagaaag agtttgattg ccttgctgtt
    20401 agtcgggttc ttcatcatat gcctgatttg gatgcggctc tctcactgtt tcatcaacat
    20461 ttgaaggaag atgggaaact catcattgct gattttacca agacagaagc taatcatcat
    20521 ggatttgatt tagctgaact ggaaaacaag ctaattgagc atggtttttc atctgtgaat
    20581 agtcagattc tctatagcgc tgaagacctg tttcaaggaa attactcaga attcttttta
    20641 atagtagccc aaaaatcact cgcctagtca gggagtgatt tttctataag gatggaaaaa
    20701 agaagggaaa tttgataaga taggaatatg gattttgaaa aaattgaaca agcttatacc
    20761 tatttactag agaatgtcca agtcatccaa agtgatttgg cgaccaactt ttatgacgcc
    20821 ttggtggagc aaaacagcat ctatctggat ggtgaaactg agctaaacca ggtcaaagac
    20881 aacaatcagg cccttaagcg tttagcacta cgcaaagaag aatggctcaa gacctaccag
    20941 tttctcttga tgaaggctgg gcaaacagaa cccttgcagg ccaatcacca gtttacacca
    21001 gatgccattg ctttgctttt ggtgtttatt gtggaagagt tgtttaaaga ggaggaaatt
    21061 actatcctcg aaatgggttc tgggatggga attctaggcg ctactttctt gacctcgctt
    21121 gataaaaagg tggattactt gggaatggaa atggatgatt tgctgattga tctggcagct
    21181 agcatggcag atgtaattgg tttgcaggct ggctttgtcc aaggagatgc cgttcgtcca
    21241 caaatgctca aagaaagcga tgtggtcatc agtgacttgc ctgttggcta ttatcctgat
    21301 gatgccgttg cgtcgcgcca tcaagttgct tctagccaag aacatactta cgcccatcac
    21361 ttgctcatgg aacaagggct taagtacctc aagtcagacg gatacgctat ttttctagct
    21421 ccgagtgatt tgttgaccag tcctcaaagt gatttgttaa aagaatggct gaaagaagag
    21481 gcgagtctgg ttgctatgat tagtctgcct gaaaatctct ttgctaatgc caaacaatct
    21541 aagactattt ttatcttaca gaagaaaaat gaaatagcag tagagccttt tgtttatcca
    21601 cttgctagct tgcaagatgc aagtgtttta atgaaattta aagaaaattt tcaaaaatgg
    21661 actcaaggta ctgaaatata aaatagattt tgttataata gttgaaaacg cttaaaaagg
    21721 ggtatcatgt tatgacaaaa acaattgcaa tcaatgcagg aagttcaagt ttgaaatggc
    21781 aattatactt aatgccagaa gaaaaagtat tggcgaaagg tttgattgaa cgtatcggtt
    21841 tgaaagattc aatttcaact gtaaaatttg acggccgttc tgaacaacaa attttggata
    21901 ttgaaaatca tacacaagcc gttaaaattt tattggatga cttgattcgt ttcgatatta
    21961 tcaaggctta tgacgagatt acaggtgttg gacatcgtgt tgttgctggt ggagaatatt
    22021 tcaaagaatc aacagttgtt gagggagatg ttttagaaaa agttgaagag ttgagtttgt
    22081 tggctcctct acacaacccg gccaatgcag caggtgttcg tgccttcaag gaattgttgc
    22141 cagacattac cagtgtagtt gtttttgata cttccttcca cacaagtatg ccagagaaag
    22201 cttatcgcta ccctctacca acaaaatatt acacagaaaa caaggttcgt aaatacggtg
    22261 ctcatggtac aagtcaccag tttgtagcag gagaagctgc aaaactcttg ggacgtccat
    22321 tagaagactt gaagttaatt acctgtcata ttggtaacgg aggctcaatt acagctgtga
    22381 aagccggcaa atctgtagac acttctatgg ggttcactcc tcttggtggt attatgatgg
    22441 gaacgcgtac aggggatatt gatccagcta tcattcctta tttaatgcaa tatacagagg
    22501 attttaacac accagaagat atcagtcgtg ttcttaaccg tgaatcaggt cttttgggag
    22561 tttctgctaa ttctagcgat atgcgcgata tagaagcagc tgtagcagaa gggaatcacg
    22621 aggctagctt ggcttatgaa atgtatgttg accgtatcca aaaacatatc ggtcagtacc
    22681 ttgcagtgct aaatggagca gatgccattg ttttcacagc aggtgtcggt gaaaatgcag
    22741 agagtttccg tcgtgatgta atctcaggga tttcgtggtt tggttgtgat gttgatgatg
    22801 aaaagaatgt ctttggcgtt acaggagaca tctcaacaga ggcagctaaa atccgtgtct
    22861 tggttattcc aacagatgaa gaattagtca ttgcccgtga cgttgaacgc ttgaaaaaat
    22921 aagtgaaact aaaaaaatat tcaatacaag gagttgggaa agttattttt ccagcttctt
    22981 tttctgatga aattgtccaa aaccttgcta tgattggctt ttttgaaaaa tatggtataa
    23041 tagtagtaat ttaatagatg gagttgagtt ttgaagaaaa actttcgtgt aaaaagagag
    23101 aaagatttta aggcgatttt caaggagggg acaagttttg ctaatcgcaa atttgtggtc
    23161 taccaattag aaaaccagaa aaaccatttt cgagtaggtc tatcagttag caaaaaactg
    23221 gggaatgccg tcactagaaa tcaaattaag cgacggattc ggcatattat ccagaatgca
    23281 aaagggagtc tggtagaaga tgtcgacttt gttgtcattg ctcgaaaagg agtcgaaacc
    23341 ttgggatacg cagagatgga gaaaaatcta ctccatgtat taaaattatc aaagatttac
    23401 cgggaaggaa atgggagtga aaaagaaact aaagttgact agtttgctag gactgtctct
    23461 gttaatcatg acagcctgtg cgactaatgg ggtaactagc gatattacag ccgaatcggc
    23521 tgatttttgg agtaaattgg tttacttctt tgcggaaatc attcgctttt tatcgtttga
    23581 tattagtatc ggagtgggga ttattctctt tacggtcttg attcgtacag tcctcttgcc
    23641 agtctttcag gtgcaaatgg tggcttctag gaaaatgcag gaagctcagc cacgcattaa
    23701 ggcgcttcga gaacaatatc caggtcgaga tatggaaagc agaaccaaac tagagcagga
    23761 aatgcgtaaa gtatttaaag aaatgggtgt cagacagtca gactctcttt ggccgatttt
    23821 gattcagatg ccggttattt tggccttgtt ccaagcccta tcaagagttg actttttaaa
    23881 gacaggtcat ttcttatgga ttaaccttgg tagtgtggat acaacccttg ttcttccgat
    23941 tttagcagca gtattcacct ttttaagtac ttggttgtcc aacaaagctt tgtctgagcg
    24001 aaatggcgct acgactgcga tgatgtatgg gattccagtc ttgattttta tctttgcagt
    24061 ttatgcgcca ggtggagtcg ccctatactg gacagtgtct aatgcttatc aagtcttgca
    24121 aacctatttc ttgaataatc cattcaagat tatcgcagag cgcgaggccg tagtacaggc
    24181 acaaaaagat ttggaaaata gaaaaagaaa agccaagaaa aaggctcaga aaacgaaata
    24241 aataaggagg aatctggtaa tggtagtatt tacaggttca actgttgaag aagcaatcca
    24301 gaaaggattg aaagaattag atattccaag aatgaaggct catatcaaag tcatttctag
    24361 ggagaaaaaa ggctttcttg gtctatttgg taaaaaacca gcccaagtgg atattgaagc
    24421 gattagtgaa acgactgttg tcaaagcaaa tcaacaggta gtaaaaggcg ttccgaaaaa
    24481 aatcaatgat ttgaacgagc ctgtgaagac ggttagtgaa gaaaccgttg accttggtca
    24541 tgtggttgat gctattaaaa aaatagagga agaaggtcaa ggtatttctg atgaagtcaa
    24601 ggctgaaatc ttaaaacatg aaagacatgc cagcactatc ttagaagaaa ctggtcacat
    24661 tgagatttta aatgaacttc aaatcgagga agcgatgagg gaagaagcag gcgctgatga
    24721 ccttgaaact gagcaagatc aaactgaaag tcaagaacta gaagacttgg gcttgaaagt
    24781 tgaaacgaac tttgatattg aacaagtagc tacggaagta atggcttatg ttcaaacgat
    24841 tattgatgac atggatgttg aggctacact ttcaaatgat tataaccgtc gtagcatcaa
    24901 tctacaaatt gacaccaacg aaccaggtcg tattatcggc taccatggta aagtcttgaa
    24961 ggccttgcaa ctgttggctc aaaattatct ttacaaccgc tattccagaa ccttctacgt
    25021 tacaatcaat gtcaatgatt atgtcgaaca ccgtgcagaa gtcttgcaga cctatgcgca
    25081 aaaattggcg actcgtgttt tggaagaagg gcgcaatcat aaaacagatc caatgtcaaa
    25141 tagcgaacgc aagattatcc atcgtattat ttcacgtatg gatggcgtga ctagttactc
    25201 tgaaggtgat gagccaaatc gctatgttgt tgtagataca gaataagtaa aatcaggttt
    25261 atcctgattt tttgctagtt agaggaggtt aaactgatgt tgaataagat aagagactat
    25321 ttagactttg ctggtttgca gtaccgtaat cctgataaag cgggagcaga gcgagagaag
    25381 atgctggcat tccgccacaa aggacaagag gctcgaaagg cttttacaga actggccaaa
    25441 gcctttcaag caagccatcc agaatggcaa ctccaacaga ctagtcagtg gatgaatcag
    25501 gcccagcgtt tgagaccaca tttttgggtt tatctacaga gagacggaca agtgacagaa
    25561 cctatgatag ccttgcgttt gtatggaaat ccttctgatt ttggtatttc cttagaagtc
    25621 agtttcatcg aacgtaagaa ggatgagcaa acactgggca agcaggccaa agttttagaa
    25681 attccaaccg ttaaagggat ttattatcta acctactcta atggtcaaag tcaacggtgg
    25741 gaggcgaatg aagaaaagcg tcgtacttta cgcgagaagg tgagaagtca agaagttcga
    25801 aaagttttag tgaaggtaga tgttcctatg acagaaaatt cgtctgaaga agaaatcgta
    25861 gaaggcttat tgaagtctta ttctaaaatt cttccctatt atcaggtgac tagaggataa
    25921 cgtgtcagtc aattattata agattacagt ccaagagtga acagtccgct gtgtaattct
    25981 tggtcttttt gtttgcgctt tcgcattata taataaactt acaaaaacaa ttcaaaagga
    26041 gaacaattat ggaagtcgtt tcaaatgttc taaattggtt ttctagcaat attttgcaga
    26101 atcccgcatt tttcgtaggt ttattggtgt tgataggata tgcacttttg aaaaaacctg
    26161 cccatgacgt tttttcaggg tttgttaaag caacagtagg gtatatgttg cttaacgtgg
    26221 gtgctggtgg tttggttaca acctttcgtc caatcttagc agctcttaac tacaaattcc
    26281 aaattggtgc agcggttatc gacccttact ttggacttgc tgcagcaaac aacaaaattg
    26341 cagcagagtt tccagatttt gttggaactg caactacagc tctattgatt ggttttggaa
    26401 taaatatctt gctcgtagct cttcgaaaga ttacgaaggt aagaaccctc tttattactg
    26461 gtcacatcat ggtacaacaa gctgcaacag tatctcttat ggttctattc ttagtaccac
    26521 aattgcgcaa tgcttacggt acagcagcga ttggtatcat ctgtggactt tactgggcag
    26581 ttagttcaaa tatgactgtt gaggcaactc aacgcttgac tggtggtggc ggatttgcga
    26641 ttggtcacca acagcaattt gcaatctggt ttgtagataa agtagcagga cgctttggta
    26701 agaaagaaga aagtttagac aatcttaaat tacctaagtt cctctcaatc ttccacgata
    26761 cagttgttgc atctgctacc ttgatgctcg tattcttcgg agccattctt ttaatcttgg
    26821 gtccagacat tatgtctaat aaagaagtca tcacttcagg aactctattc aatcctgcta
    26881 aacaagattt ctttatgtac attatccaaa cagcctttac cttctcagtt tacttgttcg
    26941 ttttgatgca aggtgtccga atgttcgtat ctgagttgac aaacgccttc caaggtattt
    27001 caaacaaatt gttgccaggt tcattcccag cggttgacgt tgcagcttct tatggatttg
    27061 gttctccaaa tgctgtcttg tcaggattta cctttggttt gattggtcaa ttgattataa
    27121 ttgtcttgct catcgtcttt aaaaatccga ttcttattat tacaggattt gtaccagtgt
    27181 tctttgacaa tgcagccatt gcggtctacg ctgataaacg cggcggatgg aaagcggctg
    27241 ttatcctttc ctttatatca ggtgtccttc aagttgctct aggagctctt tgtgtggccc
    27301 ttctcgattt ggcagcttat ggtggctacc atggaaatat cgactttgaa ttcccatggc
    27361 ttggatttgg atatatcttc aaataccttg gtattgttgg ttatgtactt gtgtgtctct
    27421 tcttgcttgt tattcctcaa cttcaatttg ccaaagcaaa agataaagag aaatattaca
    27481 acggtgaagt tcaagaagaa gcttagtatc tagaaaagga gaaataaaat ggttaaagta
    27541 ttagcagcgt gcggaaatgg aatgggttca tcaatggtta tcaagatgaa ggttgaaaat
    27601 gctctccgta agcttaatca aagagatttt acagtcaatt catgcagtgt cggtgaagct
    27661 aaaggtttag cagtaggata tgacatcgta atcgcttctc ttcatttgat tcaagaattg
    27721 gaagggcgaa ctaatgggaa gttaattggg cttgataact tgatggatga taaagaaatc
    27781 accgaaaaac tcagtcaagc actacagtaa aaggttggag ggggctggac agaaactgag
    27841 agttatcgtt tctgtccttc tccctcttaa ataaaggagg cagatatgaa tttaaaacaa
    27901 gctttaattg acaatgactc gatccgacta ggtttagagg ctaacaattg gaaagaagca
    27961 gtcaaggtag cagtagatcc cttaattgaa agtggggcaa ttttgccaga gtattacgat
    28021 gctatcattg aatcgactga agagtatggg ccttactata tcttgatgcc aggtatggct
    28081 atgccccacg ctagacctga agctggtgtg caaagtgatg ccttttcatt gattacctta
    28141 caaaatcctg ttgtattttc agatgggaaa gaggtatctg ttttgttggc actagcagca
    28201 acaagctcaa aaattcacac aagtgtagcc attccacaaa ttattgccct gtttgaatta
    28261 gaagattcta ttgcacgttt acaggcttgc cagactaaag aagatgtctt ggctatgatt
    28321 gaagaatcta aggatagccc ttatctcgaa ggattggatt tggaaagtta gaaagaggaa
    28381 taaagaaatg acaaaaagaa tacctaattt acaagttgca ttagaccatt cagacttgca
    28441 aggagcgatt aaagcagctg tttctgttgg tcaggaagta gatattatcg aagctggaac
    28501 tgtttgcttg cttcaagttg gaagtgaact ggctgaagtc ttgcgtagcc ttttcccaga
    28561 taagattatt gtggcagaca caaaatgtgc tgatgctggt ggaacagttg ctaaaaataa
    28621 tgcggttcgt ggagcagact ggatgacttg tatctgttgt gcaaccatcc ctactatgga
    28681 agcagctcta aaggctatca agactgaacg aggagaacga ggcgaaatcc agatcgagct
    28741 ttatggcgat tggacttttg aacaagctca gctttggcta gatgcaggta tctcacaagc
    28801 tatttatcac caatctcgtg atgctcttct tgctggtgaa acttggggtg aaaaagacct
    28861 taataaggtt aaaaaactca ttgacatggg cttccgtgta tctgtaacag gtggtctaga
    28921 tgtagatact ctcaaactct ttgaaggtgt tgatgtcttt acctttatcg caggtcgtgg
    28981 aattacagag gctgcggatc cagcaggagc agcgcgtgcc ttcaaggatg aaatcaaacg
    29041 aatttggggg taaatcatgg tacgtccaat tggaatttat gaaaaggcaa ccccaacaca
    29101 ctttacttgg ctagaacgtt taaattttgc caaggagtta ggctttgatt ttgtcgagat
    29161 gtctattgac gaacgtgacg agcgtttagc aagacttgac tggagtaagg aagaacgctt
    29221 ggaagttgtc aaagcaatct atggaactgg tgttcgtatt ccttctatct gtttttcagg
    29281 ccatcgtcgc tacccattgg gttcaaaaga tccagttcta gaggaaaaat ctctagaact
    29341 catgaaaaaa tgtatcgaat tagctcaaga cttgggagtt cgtacgattc aattagctgg
    29401 ttacgatgtt tactatgagg aaaagtcacc ccagacacgc caacgtttta tcaaaaattt
    29461 gagaaaagcc tgtgactggg ctgaagaagc tcaggtggta cttgctattg aaattatgga
    29521 tgatcctttc atcaatagca tcgaaaaata tttggctata gaaaaagaga ttgactctcc
    29581 cttcctcttt gtatatccag atattggtaa tgtgtctgca tggcataatg atatctatag
    29641 tgagttttat cttggtcatc atgccatcgc agctctccat ctcaaggata cttatgcagt
    29701 gacagaaagt tcaaagggcc agttccgaga tgtacctttt gggcaaggtt gtgtcaaatg
    29761 ggaagaagct ttcgatattt taaaggaaac caattataat ggacctttcc taatcgaaat
    29821 gtggtctgaa aattgtgaaa cagtagaaga aacacgcgca gccattcaag aggcgcaagc
    29881 ttttctctat ccactcatta agaaagcagg tttgatgtaa gatgaatcaa gtaatcaatg
    29941 ctatgcgtaa acgagtctgt gatgccaatc aatcattgcc aaaacatgga cttgtcaaat
    30001 ttacctgggg gaatgtatct gaagtcaatc gcgaactcgg tgtcattgtt atcaaaccat
    30061 caggcgtgga ttatgacgaa ttgacacctg aaaacatggt agtgactgat ctagatggta
    30121 agatcctaga aggggattta agaccatctt ccgacctccc aactcatgtg caattatata
    30181 aggcttggtc agaaattggt agtgtggttc acacccattc gacagaagct gttggttggg
    30241 ctcaggcagg tcgtgatatt cctttctacg gaacaaccca tgcagattat ttctacggtt
    30301 caatcccttg cgcccgtagt ttgaccaagg acgaagtaga agtggcctat gaaaaagata
    30361 ctggcctggt tatcgtagaa gaatttgaac atcgcggact taacccggtt gaagtaccag
    30421 gaattgttgt acgcaatcac ggtccattca cctggggcaa aaatccagag aatgctgttt
    30481 atcactctgt cgtactagag gaagtatcaa agatgaatcg ctttacagaa caaatcaatc
    30541 caagagttgg acctgctccc cagtacatac tagaaaaaca ctaccaacgt aaacatggac
    30601 caaatgctta ttatggtcaa aagtaagaac gatgaaggag gagaaaaaga taaatttagc
    30661 tcctcttttt acatttgatt tttattgaga gtaaagttgg agttgaagta attttgaaag
    30721 attttttaga aatagcgctt gatatatata tatggtaaaa taaaaagaat tgctgtgata
    30781 tcaatagatt tgggggattt tttaatatgg tactggataa ggcaagttgt gatttacttc
    30841 aatatttgat ggatcaagaa acgtccaaaa cgattatggc gatttcgaaa gatttgaaag
    30901 agtcaagaag gaaaatttat tatcacattg acaaaatcaa tgctgctctg ggtgacgagg
    30961 cgcttcacat cattagtatt ccacgaattg gtattcactt aacggaagag cagagagatg
    31021 cttgttgtaa actattatcg gaagtagatt cgtacgatta tatcatgagt gcgcatgaac
    31081 gtatgatgat aatgttatta tggataggta tttctaaaga acgtattacg attgaaaaat
    31141 tgatagagtt aacagaggta tctaggaata ctgttctcaa tgatttgaat agtattcgtt
    31201 atcaactaac tttggaacaa tatcaggtga ccttgcaagt gagcaagtca cagggatacc
    31261 accttcatgc ccaccctctt aataaaattc agtatcttca atcgcttcta tatcatattt
    31321 ttatggaaga aaatgccact tttgtatcta ttttagaaga taagatgaaa gagaggttag
    31381 atgatgagtg tttgctttct gttgaaatga accaattttt taaggaacag gttcctttag
    31441 ttgaacaaga tttagggaag aaaataaacc atcatgaaat aacttttatg ttgcaggttc
    31501 taccttattt gctgttaagc tgtcataatg ttgaacagta tcaagaaaga catcaggata
    31561 tagagaaaga attttctttg ataagaaaaa gaatagagta tcaggtgtct aagaaattag
    31621 gagaacggtt gtttcaaaag tttgaaattt ctttgtcagg acttgaagtt tctcttgtag
    31681 ctgttctcct cctctcctat cgtaaagatt tggatattca tgcagaaagt gatgattttc
    31741 ggcaattaaa acttgcttta gaagaattta tctggtattt tgaatcacaa atccgaatgg
    31801 agattgagaa caaggatgat ttgttacgaa atttgatgat ccactgtaaa gccttgttat
    31861 ttagaaagac ttacggtatt ttttctaaaa atcctctaac aaaacaaatt cgatccaagt
    31921 atggagaatt atttttagtc actagaaaat ctgcggaaat tttagaagga gcatggttta
    31981 ttcggctaac agacgatgat attgcctatt tgacgattca tattggagga tttttaaaat
    32041 atacaccatc gtctcaaaaa aatatgaaaa aagtttatct cgtttgtgat gaaggtgttg
    32101 cggtttcgag acttttgctg aaacaatgca aactttattt tccaaatgag caaattgaca
    32161 ctgtatttac aacagaacaa tttaagagtg tggaagatat tgcacaagtt gatgtagtga
    32221 ttactactaa tgatgatttg gatagcagat ttccgatttt aagggttaat cctatccttg
    32281 aagcagaaga tattttgaaa atgctagact atcttaaaca caatatattt cgtaataaga
    32341 gcaaaagttt cagtgaaaat ctttctagtc ttatttcgtc ttatattgta gacagcaagt
    32401 tggctagtaa gttccaagaa gaggttcaaa cacttataaa tcaagaaata gtagttcaag
    32461 cttttttgga agatatttga aggacagtcc aatgatgaac acaaacctgt gtttttcttg
    32521 gtctttttta gtgttttgaa gggtggtata ctaatctcaa agataacaat tatatccaaa
    32581 ggaggcaaca tatgccaaac gtcaaagaaa ttacaagaga gtcatggatt ttagccactt
    32641 tcccagagtg gggaacatgg ttgaacgaag aaatcgaaga agaagtcgta cctgaaggca
    32701 actttgccat gtggtggcta ggcaactgtg gtacttggat taagacacca gctggtgcta
    32761 acgttgtcat ggacctttgg tcaaaccgtg gaaaatcaac caaaaaagtg aaagatatgg
    32821 ttcgtgggca ccaaatggca aatatggcag gtgttcgtaa gttgcaacca aacttgcgtg
    32881 ttcagccaat ggttatcgat ccatttgcta tcaacgaact agactattac ttagtttcac
    32941 acttccacag tgatcatatc gacccataca cagctgcagc aattctcaac aatcctaagt
    33001 tagagcatgt taagtttatc ggtccttacc actgtggacg aatctgggaa ggatgggggg
    33061 ttccaaaaga acgtatcatc gttgttaaac caggtgacac tatcgaatta aaagatatga
    33121 agattcatgc agtagaatca tttgaccgta cttgcttggt aactctccca gtgaacggtg
    33181 ctgatgagac aggcggtgaa cttgctggct tggctgttac agatgaagaa atggctcaaa
    33241 aggctgttaa ctatatcttt gaaacaccag gtggaaccat ctatcatggt gcagattctc
    33301 acttctcaaa ctattttgca aaacatggta aagactttaa aattgatgtt gctttgaata
    33361 actatggtga aaatccggta ggtatccaag acaaaatgac atctatcgac cttcttcgta
    33421 tggcagaaaa tctgcgtacc aaagtcatta tcccagttca ctatgatatc tggtctaact
    33481 tcatggcttc tactaatgag attctagaac tttggaaaat gcgaaaagat cgcttgcaat
    33541 acgatttcca tccatttatc tgggaagttg gcggtaagta cacttatcct caagatcaac
    33601 acttagtaga ataccatcat ccacgtggtt ttgatgattg ttttgaacaa gactctaaca
    33661 ttcaatttaa agctttgcta taatataaaa atattctttg gaggttatcc gtatgttgca
    33721 tgatacggat aattttcata taatagtaaa atagaatgtg tgattcaata atcacctcaa
    33781 atagaaagga aattctatgt caaatctatc tgttaatgca attcgttttc taggtattga
    33841 cgccattaat aaagccaact caggtcatcc aggtgtggtt atgggagcgg ctccgatggc
    33901 ttacagcctc tttacaaaac aacttcatat caatccagct caaccaaatt ggattaaccg
    33961 cgaccgcttt attctttcag caggtcatgg ttcaatgctc ctttatgctc ttcttcacct
    34021 ttctggtttt gaagatgtca gcatggatga gattaagagc ttccgtcaat ggggttcaaa
    34081 aacaccaggt cacccagaat ttggtcatac ggcagggatt gatgctacga caggtcctct
    34141 agggcaaggg atttcaactg ctactggttt tgcccaagca gaacgtttct tggcagccaa
    34201 atataaccgt gaaggctaca atatctttga ccactatact tacgttatct gtggagacgg
    34261 agacttgatg gaaggtgtct caagcgaggc agcttcatac gcaggtttgc aaaaacttga
    34321 taagttggtt gttctttatg attcaaatga tatcaacttg gatggtgaga caaaggattc
    34381 ctttacagaa agtgttcgtg accgttacaa tgcctacggt tggcatactg ccttggttga
    34441 aaatggaaca gacttggaag ccatccatgc tgctatcgaa acagcaaaag cttcaggcaa
    34501 gccatctttg attgaagtga agacggttat tggatatggt tctccaaaca aacaaggaac
    34561 taatgctgta cacggcgccc ctcttggagc agatgaaact gcatcaactc gccaagccct
    34621 cggttgggac tacgaaccat ttgaaattcc agaacaagta tatgctgatt tcaaagaaca
    34681 tgttgcagac cgtggcgcat cagcttatca agcttggact aaattagttg cagattataa
    34741 agaagctcat ccagaactgg ctgcagaagt agaagccatc atcgacggac gtgatccagt
    34801 cgaagtgact ccagcagact tcccagcttt agaaaatggt ttttctcaag caactcgtaa
    34861 ttcaagtcaa gatgccttga atgttgtggc agctaaatta ccaaccttcc taggtggatc
    34921 agctgacctt gctcactcaa acatgactta tatcaagacg gatggacttc aagacgatac
    34981 caatcgcttg aatcgtaaca ttcagtttgg tgttcgtgaa tttgcaatgg gaacaatctt
    35041 gaacgggatg gcccttcatg gtggacttcg tgtatacggt ggaactttct tcgtcttctc
    35101 tgactatgtg aaggcagctg tccgcttgtc agccttacaa ggacttcctg tgacttatgt
    35161 ctttacccat gattcaatcg cagttgggga agatggtccg actcacgaac cagttgagca
    35221 tttagcaggt cttcgtgcta tgccaaatct aaatgttttc cgtccagcag atgcgcgtga
    35281 aacgcaagca gcttggtacc ttgcagtgac aagtgagaaa acaccaactg cccttgtctt
    35341 gacacgtcaa aacttgactg ttgaagatgg aacagacttc gacaaggttg ctaaaggtgc
    35401 ttatgttgta tatgaaaatg cagccgactt tgataccatc ttgattgcga caggttcaga
    35461 ggttaatctt gctgtctcag ctgctaaaga attggctagt caaggcgaaa aaatccgcgt
    35521 agtcagcatg ccatctacag atgtctttga taaacaagat gcagcttaca aggaagaaat
    35581 tcttccaaat gcagtccgcc gtcgtgttgc agtcgaaatg ggtgcaagtc aaaactggta
    35641 caaatatgtt ggtctcgatg gtgccgttct aggtattgat accttcggag cctctgcccc
    35701 agcaccaaaa gtattggcag aatatggctt tactgtcgaa aatcttgtaa aagttgttcg
    35761 aaatttgaaa taatcctaaa aatcagggcg taagctctgg tttttcttac cagaaaagta
    35821 aggtacaatc ttgtaaaagt agctgaaatt tgatatagta gtcctatgta aaagacaaag
    35881 gagaaaacaa tgaatccaaa tattactttt ttaatcatgc ttgtaggtat gatggccttg
    35941 atgttcttta tgcaacgttc tcaaaagaaa caagctcaaa agcgtatgga aagcttaaat
    36001 aaactacaaa aaggctatga agtgattaca atcggtggac tttatggaac agtcgatgaa
    36061 gtagatacgg agaagggaac aatagttctt gacgtagatg gagtttactt gacttttgaa
    36121 ctagctgcta tcaagacagt attaccgctg aaagaaacag cttcactaga aggcgcaatt
    36181 gaaaaataag acgggatcac gaactcccgt tttctataaa agaaaggaaa tgggatgaaa
    36241 aaattagtct ttgtctgtct gggaaatatt tgccgtagcc ctatggccga gtttgttatg
    36301 aaatcaatga cagataacta cgaaatccaa agtcgagcaa cttcctcttg ggaacatggc
    36361 aatccgattc ataaggggac tcagggaatt tttcaagagt atgagattcc ttatgacaag
    36421 aacaagacat cgcttcagat tagtaaggaa gattttgaag cctttgatta tattatcgga
    36481 atggacgctt caaatatttc tgacttacgt cagatgtgtc cagtagactg tcaagataag
    36541 atttactcat tttcatctga aagtgttcca gacccttggt atacaggaga ttttgaagaa
    36601 acctatcgac gtgttcaaga gggctgtcaa gcttggttag aacgtttaga aaaggagagt
    36661 taaggtggaa aatcttacga atttttacga aaagtatcgt gtctatctga ctcgtccacg
    36721 tttagagctt ttggcagtag ttaccattgt tttctgtgct gtactcgtct tttttctaaa
    36781 tattccagga aaaggtgtct taaaactcga taatggaacg attgtttatg atggcagtct
    36841 tgtccgtggt aaaatgaatg gccaaggtac cattaccttc caaaatggag accaatatac
    36901 aggtggcttc aacaatggag ccttcaacgg aaaaggtacc tttcaatcta aagaaggctg
    36961 gacctacgaa ggtgattttg taaatggtca ggctgaagga aaagggaaac taacaacaga
    37021 acaagaagtc gtttatgaag gaacttttaa acaaggcgtt tttcaacaaa aataaagcct
    37081 ccttatcaaa ggaggtatta ttagaatcac aaggtaagcg cttacctgta aatccctttc
    37141 tttccaaatc cctcttccaa gcaagtttgt gaaataaaaa atatttgaaa taaatttcac
    37201 aaacttcaaa gataaaactt gataagaaaa gaaaatgaga aaagtttcac aagagtttaa
    37261 aaattctttg tgaaatgttt atgaaactgt ttacaaagtt gaaataatgc gttataataa
    37321 acttgtgaaa aaattaacaa aggatatcgt tccttgaaag ctatggagga aaatatggct
    37381 gataaaaaaa ctgtgacacc agaggaaaag aaactcgttg ctgaaaaaca cgtagatgag
    37441 ttggttcaaa aagctctagt tgcccttgaa gaaatgcgta aattggatca agaacaagtt
    37501 gactacatcg ttgccaaagc atcagtagca gctttggatg cccacggaga attggcttta
    37561 catgcctttg aagaaacagg acgtggtgta tttgaagaca aagcaactaa gaacttgttt
    37621 gcctgtgaac acgtagtaaa caacatgcgc cacactaaga cagttggcgt tatcgaagaa
    37681 gacgatgtaa caggattgac tcttattgct gaaccagttg gtgttgtttg tggtattact
    37741 ccaacaacaa acccaacatc aacagcaatc ttcaaatcat tgatttcatt gaagacacgt
    37801 aacccaatcg tctttgcctt ccatccatca gcacaagaat catctgctca tgcagctcgt
    37861 atcgtccgcg atgcagctat cgcagctggt gctcctgaaa actgtgtgca atggattact
    37921 caaccatcta tggaagcaac aagtgccctt atgaaccacg aaggtgttgc gacaatcctt
    37981 gcaacaggtg gtaatgccat ggttaaggcg gcttattcat gtggtaaacc agctcttggg
    38041 gtaggtgccg gaaacgttcc agcttatgtt gaaaaatcag caaacattcg tcaagcagca
    38101 cacgatatcg tcatgtctaa atcatttgat aacggtatgg tctgtgcatc tgaacaagca
    38161 gttatcattg ataaagaaat ttacgatgaa tttgtagcag agttcaaatc ttaccacact
    38221 tactttgtaa acaaaaaaga aaaagctctt cttgaagagt tctgcttcgg cgtcaaagca
    38281 aacagcaaaa actgtgctgg tgcaaaattg aacgctgaca tcgttggtaa acaagcaact
    38341 tggattgcag aacaagcagg atttacagtt ccagaaggaa caaacattct tgctgcagaa
    38401 tgtaaagaag ttggcgaaaa tgagccattg actcgtgaaa aattgtcacc agttattgca
    38461 gttttgaaat ctgaaagccg tgaagatggt attactaagg ctcgtcaaat ggttgaattt
    38521 aacggtcttg gacactcagc agctatccac acagctgacg aagaattgac taaagaattt
    38581 ggtaaagctg ttaaagctat tcgtgttatc tgtaactcac cttctacttt tggtggtatc
    38641 ggggacgttt acaatgcctt cttgccatca ttgacacttg gatgtggttc ttacggacgc
    38701 aactcagttg gggataacgt tagtgccatt aacctcttga atatcaaaaa agtcggaaga
    38761 cggagaaata acatgcaatg gatgaaactt ccttcaaaaa catactttga acgtgattca
    38821 attcaatacc ttcaaaaatg tcgtgacgtt gaacgtgtca tgatcgttac tgaccatgcc
    38881 atggtagagc ttggtttcct tgatcgtatc atcgaacaac tggaccttcg tcgcaataag
    38941 gttgtttacc aaatctttgc ggatgtagaa ccggatccag atatcacaac tgtaaaccgt
    39001 ggtactgaga ttatgcgtgc cttcaaacca gataccatca tcgcactcgg tggtgggtct
    39061 ccaatggatg ctgccaaagt aatgtggctc ttctacgagc aaccagaagt ggacttccgt
    39121 gaccttgtcc aaaaattcat ggatatccgt aaacgtgcct tcaagttccc attgcttggt
    39181 aagaagacta aattcatcgc gattccaact acatctggta caggatctga agtaacacca
    39241 tttgccgtta tctctgataa agcaaacaac cgtaaatacc caatcgctga ctactcattg
    39301 acaccaactg tggcaatcgt agatcctgct ttggtattga cagttccagg atttgttgct
    39361 gctgatactg gtatggacgt attgactcac gcgacagaag catacgtatc acaaatggct
    39421 agtgactaca ctgatggttt agcacttcaa gccattaaat tggtctttga aaatctcgaa
    39481 agctcagtta agaatgcaga cttccactca cgtgagaaaa tgcataacgc ttcaacaatc
    39541 gctggtatgg cctttgccaa tgccttccta ggtatttctc actcaatggc ccataagatt
    39601 ggtgcgcaat tccacacaat ccacggtcgt acaaatgcca tcttgcttcc atacgttatc
    39661 cgttacaacg gtacacgtcc agctaagaca gcaacatggc ctaagtacaa ctactaccgt
    39721 gcagatgaaa aataccaaga tatcgcacgc atgcttggac ttccagcttc tactccagaa
    39781 gaaggggttg aatcttacgc aaaagctgtc tacgaactcg gtgaacgtat tgggatccaa
    39841 atgaatttta gagaccaagg aattgacgaa aaagaatgga aagaacattc tcgtgaatta
    39901 gccttcctgg cttatgaaga ccaatgttca ccagctaacc cacgtcttcc aatggtagac
    39961 catatgcaag aaatcatcga agatgcatac tatggctaca aagaaagacc aggacgccgt
    40021 aaataattgt ttatcagtct agaagcaaga caaaaactca atttgaggga aagaaccagt
    40081 aatttttcta tgataaaagg catcctatca aggtttttga atacctgata ggatgccttt
    40141 ttatgatgtt gaggcctttt tgcccttttt gaaaaactag aatagaaaca aaatatatag
    40201 taggttgaaa ctagaatagt acacatctgc ttctaaaaca ttgttagaat tcgatttgac
    40261 tgtcctgatc gatttgtcct gttcttattt cattttaata tataaaaaat ata
//
LOCUS       DAVHIZ010000016        40296 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.016, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000016 DAVHIZ010000000
VERSION     DAVHIZ010000016.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 40296)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 40296)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..40296
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.016"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..508)
                     /locus_tag="VVO18_000836"
     CDS             complement(<1..508)
                     /locus_tag="VVO18_000836"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU5586022.1"
                     /translation="MKKVKLGEVCEILSGYAFKSSQFNDNKIGLPLIRIRDVERGFSD
                     TYFEGTYPEEYLIKNGDLLITMDGSFILKKWEGDLALLNQRVCKIKITDKSVDEGYIS
                     WLIPKFLKEIEDKTPFVTVKHLSVAKIKDISFVLPNKLEQKLIAKKLNTISQIYDFRK
                     IQSEKFNEL"
     gene            complement(521..2014)
                     /locus_tag="VVO18_000837"
     CDS             complement(521..2014)
                     /locus_tag="VVO18_000837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627753.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEU5586023.1"
                     /translation="MITGELKNKIDQLWEILWTEGNANPLTNIEQLTYLLFMKDLDSV
                     ELGRESDAEFLGIPYEGVFPKDKPEYRWSTFKNIGDAQEVYRLMTQEIFPFIKNLKGD
                     TDDTAFSRYMREAIFQINKPATLQKAISILDVFPTRGLDVDFDNDKQSITDIGDIYEY
                     LLSKLSTAGKNGQFRTPRHIIDMMVELMQPTIKDIISDPAMGSAGFLVSASRYLKRKK
                     DEWETNTDNINHFHNQMFHGNDTDTTMLRLGAMNMMLHGVENPQISYLDSLSQDNEEA
                     DKYTLVLANPPFKGSLDYNSTSNDLLATVKTKKTELLFLSLFLRTLKPGGRAAVIVPD
                     GVLFGSSKAHKGIRQEIVENHKLDAVISMPSGVFKPYAGVSTAILIFTKTGNGGTDKV
                     WFYDMKADGLSLDDKRQPISDNDIPDIIERFHHLEKEAERQRTDQSFFVPVAEIKEND
                     YDLSINKYKEIEYEKVEYEPTEVILKKINDLEKEIQAGLAELEKLLK"
     gene            complement(2522..3688)
                     /locus_tag="VVO18_000838"
     CDS             complement(2522..3688)
                     /locus_tag="VVO18_000838"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001108652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEU5586024.1"
                     /translation="MNYLVISPYYPQNFQQFTIELANKGITVLGIGQESYEQLDEPLR
                     NSLTEYFRVDNLENIDEVKRAVAFLFYKHGPIDRIESHNEYWLELDATLREQFNVFGA
                     KPEDLKKTKYKSEMKKLFKKAGVPVVPGAVIKTEADVDQAVKEIGLPMIAKPDNGVGA
                     AATFKLETEDDINHFKQEWDHSTLYFFEKFVTSSEICTFDGLVDKDGKIVFSTTFDYA
                     YTPLDLMIYKMDNSYYVLKDMDPKLRKYGEAIVKEFGMKERFFHIEFFREGDDYITIE
                     YNNRPAGGFTIDVYNFAHSLDLYRGYAAIVAGEEFPASDFETQYCLATSRRANAHYVY
                     SEEDLLAKYSQQFKVKKVMPAAFAELQGDYLYMLTTPSRQEMDQMIADFGQRQE"
     gene            complement(3701..4440)
                     /locus_tag="VVO18_000839"
                     /pseudo
     CDS             complement(3701..4440)
                     /locus_tag="VVO18_000839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000546805.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="esterase family protein"
     gene            complement(4462..5286)
                     /locus_tag="VVO18_000840"
     CDS             complement(4462..5286)
                     /locus_tag="VVO18_000840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU5586025.1"
                     /translation="MNQSYFYLKMKEHKLKVPYTGKERRVRILLPKDYEKDTDRSYPV
                     VYFHDGQNVFYSKESFIGYSWKIIPAIKRNPDISRMIVVAIDNDGMGRMNEYAAWKFQ
                     ESPIPEQQFGGKGVEYAEFVMEVVKPFIDETYRTKADCQHTAMIGSSLGGNITQFIGL
                     EYQDQIGCLGVFSSANWLHQEAFNRYIECQKLSPDQRIFIYVGTEEADDTDKTLMDGN
                     IKQAYIDSSLCYYHDLIAGGVHLDNLVLKVQSGAIHSEIPWSENLPDCLRFFAEKW"
     gene            complement(5424..6638)
                     /gene="thiI"
                     /locus_tag="VVO18_000841"
     CDS             complement(5424..6638)
                     /gene="thiI"
                     /locus_tag="VVO18_000841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001200101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 4-thiouridine(8) synthase ThiI"
                     /protein_id="HEU5586026.1"
                     /translation="MQYSEIMIRYGELSTKGKNRMRFINKLRNNISDVLSIYTQVKVT
                     ADRDRAHAYLNGADYTAVAESLKQVFGIQNFSPVYKVEKSVEVLKSSVQEIMRDIYKE
                     GMTFKISSKRSDHNFELDSRELNQTLGGAVFEAIPNVQVQMKSPDINLQVEIREEAAY
                     LSYETIRGAGGLPVGTSGKGMLMLSGGIDSPVAGYLALKRGVDIEAVHFASPPYTSPG
                     ALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRITDRIR
                     EVRNGLVIINGESLGQVASQTLESMKAINAVTNTPIIRPVVTMDKLEIIDIAQEIDTF
                     DISIQPFEDCCTIFAPDRPKTNPKIKNAEQYEARMDVEGLVERAVAGIMITEITPQAE
                     KDEVDDLIDNLL"
     gene            complement(6647..7789)
                     /locus_tag="VVO18_000842"
     CDS             complement(6647..7789)
                     /locus_tag="VVO18_000842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU5586027.1"
                     /translation="MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHRLGDQATRI
                     LDASRQQIADLVGKKSDEIFFTSGGTEGDNWVIKGVAFEKAQFGKHIIVSAIEHPAVK
                     ESALWLKSQGFEVDFAPVDKKGLVDVEALAGLIRPDTILVSIMAVNNEIGSIQPIEAI
                     SEFLADKPTISFHVDAVQALAKIPTEKYLTERVDCATFSSHKFHGVRGVGFVYIKSGK
                     KITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIHQALL
                     NYPDIFVFSDEEDFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGT
                     LIAMGVDKDKAKSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR"
     gene            7927..8355
                     /locus_tag="VVO18_000843"
     CDS             7927..8355
                     /locus_tag="VVO18_000843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073927.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586028.1"
                     /translation="MSNYRRTSKPKTEHIKKGFTVFQKTITTIGSILGLITAGITIMN
                     ALDNNKNTKKEPTTSQTTTFVKEIQKESPQENTTPNKENNTSQEKTQQEETPKSSVKE
                     EKKEDQKTATQDSTTPATSKPATENEKQPNTPTSENKSNQ"
     gene            complement(8399..10624)
                     /locus_tag="VVO18_000844"
     CDS             complement(8399..10624)
                     /locus_tag="VVO18_000844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000908822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU5586029.1"
                     /translation="MLISLGIAILLIFAAFKLGAAGITLYNLIRLLVGSLAYLAIFGL
                     LIYLFFFKWIRKQEGLLSGFFTIFAGLLLIFEAYLVWKYGLDKSVLKGTMAQVVTDLT
                     GFRTTSFAGGGLIGVALYIPTAFLFSNIGTYFIGSILILVGSLLVSPWSVYDIAEFFS
                     RGFAKWWEGHERRKEERFVKQEEKARQKAEKEARLEQEETEKALLDLPPVDMETGEIL
                     TEEAVQNLPPIPEEKWVEPEIILPQTELKFPEQEDDSDDEDVQVDFSAKEALEYKLPS
                     LQLFAPDKPKDQSKEKKIVRENIKILEATFASFGIKVTVERAEIGPSVTKYEVKPAVG
                     VRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSDIATVSFRELWEQSQTK
                     AENFLEIPLGKAVNGTARAFDLSKMPHLLVAGSTGSGKSVAVNGIIASILMKARPDQV
                     KFMMVDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFAKVGVRNI
                     AGFNAKVEEFNSQSEYKQIPLPFIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGI
                     HMILATQRPSVDVISGLIKANVPSRVAFAVSSGTDSRTILDENGAEKLLGRGDMLFKP
                     IDENHPVRLQGSFISDDDVERIVNFIKTQADADYDESFDPGEVSENEGEFSDGDAGGD
                     PLFEEAKSLVIETQKASASMIQRRLSVGFNRATRLMEELEMAGVIGPAEGTKPRKVLQ
                     Q"
     gene            complement(10788..12740)
                     /locus_tag="VVO18_000845"
     CDS             complement(10788..12740)
                     /locus_tag="VVO18_000845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5586030.1"
                     /translation="MKIQDLLRKDVMLLDLQATEKTAVIDEMIKNLTDHGYVTDFETF
                     KEGILAREALTSTGLGDGIAMPHSKNAAVKEATVLFAKSNKGVDYESLDGQATDLFFM
                     IAAPEGANDTHLAALAELSQYLMKDGFADKLRQATSADQVIELFDQASEKTEELVQAP
                     ANDSGDFIVAVTACTTGIAHTYMAQEALQKVAAEMGVGIKVETNGASGVGNQLTAEDI
                     RKAKAIIIAADKAVEMDRFDGKPLINRPVADGIRKTEELINLALSGDTEVYRAANGAK
                     AATASNEKQSLGGAFYKHLMSGVSQMLPFVIGGGIMIALAFLIDGALGVPNENLGNLG
                     SYHELASMFMKIGGAAFGLMLPVFAGYVAYSIAEKPGLVAGFVAGAIAKEGFAFGKIP
                     YAAGGEATSTLAGVSSGFLGALVGGFIAGALVLAIKKYVKVPRSLEGAKSILLLPLLG
                     TILTGFVMLAVNIPMAAINTAMNDFLGGLGGGSAVLLGIVLGGMMAVDMGGPVNKAAY
                     VFGTGTLAATVSSGGSVAMAAVMAGGMVPPLAIFVATLLFKDKFTKEERNSGLTNIIM
                     GLSFITEGAIPFGAADPARAIPSFILGSAVAGGLVGLTGIKLMAPHGGIFVIALTSNA
                     LLYLVSVLVGAIVSGVVYGYLRKPQA"
     gene            complement(12737..13648)
                     /gene="pfkB"
                     /locus_tag="VVO18_000846"
     CDS             complement(12737..13648)
                     /gene="pfkB"
                     /locus_tag="VVO18_000846"
                     /EC_number="2.7.1.56"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015605104.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-phosphofructokinase"
                     /protein_id="HEU5586031.1"
                     /translation="MIYTVTLNPSIDYIVRLDQVKVGSVNRMDSDDKFAGGKGINVSR
                     VLKRLNIPNTATGFIGGFTGKFITDTLAEEEIETRFVQVAEDTRINVKIKADQETEIN
                     GTGPTVESVQLEELKAILSSLTAEDTVVFAGSSAKNLGNVIYKDLISLTRQTGAQVVC
                     DFEGQTLIDSLDYQPLLVKPNNHELGAIFGVKLESLDEIEKYARELLAKGAQNVIISM
                     AGDGALLVTSEGAYFAKPIKGTVKNSVGAGDSMVAGFTGEFVKSKDAVEAFKWGVACG
                     TATTFSDDLATAEFIKETYGKVEVEKR"
     gene            complement(13645..14385)
                     /locus_tag="VVO18_000847"
     CDS             complement(13645..14385)
                     /locus_tag="VVO18_000847"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU5586032.1"
                     /translation="MLKTERKQLILEELNQHHVVSLEKLVSLLETSESTVRRDLDELE
                     AENKLRRVHGGAELPYSLQEEETIQEKSVKNLQEKKLLAQKAASLIKEKDVIFIDAGT
                     TTAFLIHELVNKNVTVVTNSIHHAAQLVEKQIPTVMVGGNVKTATDASIGGVALNQIN
                     QLHFDRAFIGINGVDDGYYTTPDMEEGAVKRAILENAKQTYVLVDSSKIGQTCFAKVA
                     PLKRAIVITSQGHELLQVIKEKTEVIEV"
     gene            14548..14635
                     /locus_tag="VVO18_000848"
     tRNA            14548..14635
                     /locus_tag="VVO18_000848"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:14582..14584,aa:Ser,seq:gga)
     gene            complement(14828..15175)
                     /gene="ssrA"
                     /locus_tag="VVO18_000849"
     tmRNA           complement(14828..15175)
                     /gene="ssrA"
                     /locus_tag="VVO18_000849"
                     /product="transfer-messenger RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00023"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00023"
     gene            complement(15821..16930)
                     /locus_tag="VVO18_000850"
     CDS             complement(15821..16930)
                     /locus_tag="VVO18_000850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEU5586033.1"
                     /translation="MFRRNKLFFWTTEILLLTIIFYLWRQMGSLINPFVSVLNTIMIP
                     FLLGGFLYYLTNPIVTFLNKVCKLNRLLGILITLCTLVWGMVIGVVYLLPILINQLSS
                     LIISSQTIYSRVQDLIIDLSNYPALQNLDVEATIQQLNLSYVDILQNILNSVSNSVGS
                     VLSALISTVLILIMTPVFLVYFLLDGHKFLPMLERTILKRDRLHIAGLLKNLNATIAR
                     YISGVSIDAIIIGCLAYIGYSIIGLKYALVFAIFSGVANLIPYVGPSIGLIPMIIANI
                     FTDPHRLLIAVIYMLVVQQVDGNILYPRIVGSVMKVHPITILVLLLLSSNIYGVVGMI
                     VAVPTYSILKEISKFLSRLYENHKIMKERERELAK"
     gene            17033..18274
                     /locus_tag="VVO18_000851"
     CDS             17033..18274
                     /locus_tag="VVO18_000851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="HEU5586034.1"
                     /translation="MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILY
                     EKDATQPVEIASITKLITVYLVYEALENGSITLSTPVDISDYPYQLTTNSEASNIPME
                     ARNYTVEELLEATLVSSANSAAIALAEKIAGSEKDFVDMMRAKLLEWGIQDATVVNTT
                     GLNNETLGDNIYPGSKKDEENKLSAYDVAIVARNLIKKYPQVLEITKKPSSTFAGMTI
                     TSTNYMLEGMPAYRGGFDGLKTGTTDKAGESFVGTTVEKGMRVITVVLNADHQDNNPY
                     ARFTATSSLMDYISSTFTLRKIVQQGDAYQDSKAPVQDGKEDTVTAVAPEDIYLIERV
                     GNQSSQSVQFTPDSKAISAPLEAGTVVGHLTYEDKDLIGQGYITTERPSFEMVADKKI
                     EKAFFLKVWWNQFVRFVNEKL"
     gene            complement(18473..19885)
                     /gene="sufB"
                     /locus_tag="VVO18_000852"
     CDS             complement(18473..19885)
                     /gene="sufB"
                     /locus_tag="VVO18_000852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufB"
                     /protein_id="HEU5586035.1"
                     /translation="MAEERVEPKPIDLGEYKFGFHDDVEPVLSTGKGLNEGVIRELSA
                     VKGEPEWMLEFRLKSYETFKKMPMQTWGADLSEIDFDDLIYYQKPSDKPARSWDDVPE
                     KIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEFQKLGIIFTDTDSALKEYPD
                     LFKQYFAKLVPPTDNKLAALNSAVWSGGTFIYVPKGVKVDIPLQTYFRINNENIGQFE
                     RTLIIVDEGASVHYVEGCTAPTYSSNSLHAAIVEIFALDGAYMRYTTIQNWSDNVYNL
                     VTKRAKAQKDATVEWIDGNLGAKTTMKYPSVYLDGEGARGTMLSIAFANAGQHQDTGA
                     KMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVTFNKNSKKSVSHIECDTIIMDDLSASD
                     TIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELP
                     MEYAVELNRLISYEMEGSVG"
     gene            complement(19939..20379)
                     /locus_tag="VVO18_000853"
     CDS             complement(19939..20379)
                     /locus_tag="VVO18_000853"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SUF system NifU family Fe-S cluster assembly
                     protein"
                     /protein_id="HEU5586036.1"
                     /translation="MALSKLDSLYMAVVADHSKNPHHQGKLEDAEQISLNNPTCGDVI
                     NLSVKFDAEDRLEDIAFLNSGCTISTASASMMTDAVLGKTKQEILELATIFSEMVQGQ
                     KDERQGQLGDAAFLSGVAKFPQRIKCATLAWNALKKTIENQEKQ"
     gene            complement(20366..21592)
                     /locus_tag="VVO18_000854"
     CDS             complement(20366..21592)
                     /locus_tag="VVO18_000854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU5586037.1"
                     /translation="MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINS
                     YYEQDNANVHRGVHTLAERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVAR
                     FAEEILAEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEDLRAKLTD
                     KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFA
                     FSGHKMAGPTGIGVLYGKEKYLEQMSPVEFGGEMIDFVYEQFASWKELPWKFEAGTPN
                     MAGAIGLATAVDYLEKIGMDAVEAHEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVI
                     AFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDK
                     LVDALQKTKEFFNGTF"
     gene            complement(21603..22865)
                     /gene="sufD"
                     /locus_tag="VVO18_000855"
     CDS             complement(21603..22865)
                     /gene="sufD"
                     /locus_tag="VVO18_000855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly protein SufD"
                     /protein_id="HEU5586038.1"
                     /translation="MTRENIKLFSEMHAEPSWLADLRQKAFDKIETLELPVIERVKFH
                     RWNLGDGTITENEPSANVPDFTALDHHLKLVQVGTQTVFEQTPVELAEQGVVFTDFHS
                     ALEEIPELIEEFFMSSVKYDDDKLAAYHTAYFNSGAVLYIPDNVEITEPIEGIFYQDS
                     DSNVPFNKHIMIIAGKNSKISYLERLESRGEGSDKATANITVEVIARSGAQVKFAAID
                     RLGENVTAYISRRGKLGNDASIDWAIGVMNEGNVVADFDSDLIGNGSHADLKVVALSS
                     GRQVQGIDTRVTNYGCNSIGNILQHGVILEKATLTFNGIGHIIKGAKGADAQQESRVL
                     MLSDQARSDANPILLIDENDVTAGHAASIGQVDPEDMYYLMSRGLDKATAERLVVRGF
                     LGSVIVEIPVKEVRDEMIATIEEKLSKR"
     gene            complement(22893..23663)
                     /gene="sufC"
                     /locus_tag="VVO18_000856"
     CDS             complement(22893..23663)
                     /gene="sufC"
                     /locus_tag="VVO18_000856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000114488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fe-S cluster assembly ATPase SufC"
                     /protein_id="HEU5586039.1"
                     /translation="MSVIEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKST
                     LSAAIMGNPNYEVTKGEVLFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLR
                     AAMNAGKEDDEKISVREFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLL
                     MLEPTFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDVVHV
                     MMEGRVVLSGGPELAARLEREGYAKLAEELGYDYKEEL"
     gene            complement(23813..24007)
                     /locus_tag="VVO18_000857"
     CDS             complement(23813..24007)
                     /locus_tag="VVO18_000857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041548.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3272 domain-containing protein"
                     /protein_id="HEU5586040.1"
                     /translation="MNKQQFIIMALFTAAETYFFNEAWMTGRYIMAAFWAILLFRNFR
                     VSYVMGKIVDVIDQHFNRKD"
     gene            complement(24035..25690)
                     /gene="dnaX"
                     /locus_tag="VVO18_000858"
     CDS             complement(24035..25690)
                     /gene="dnaX"
                     /locus_tag="VVO18_000858"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit gamma/tau"
                     /protein_id="HEU5586041.1"
                     /translation="MYQALYRKYRSQNFSQLVGQEVVAKTLKQAVEQEKISHAYLFSG
                     PRGTGKTSVAKIFAKAMNCPNQVGGEPCNNCYICQAVTDGSLEDVIEMDAASNNGVDE
                     IREIRDKSTYAPSLARYKVYIIDEVHMLSTGAFNALLKTLEEPTQNVVFILATTELHK
                     IPATILSRVQRFEFKSIKTQDIKEHIHYILEKENISSEPEAVEIIARRAEGGMRDALS
                     ILDQALSLTQGNELTTTISEEITGTISLSALDDYVAALSQQDVPKALSCLNLLFDNGK
                     SMTRFVTNLLHYLRDLLIVQTGGENTHHSSVFVENLALPQKNLFEMIRLATVSLADIK
                     SSLQPKIYAEMMTVRLAEIKSEPALSGAVENEIATLRQEVARLKQELSNVGAVPKQVA
                     PAPSRPATGKTVYRVDRNKVQSILQEAVENPDLARQNLIRLQNAWGEVIESLGGPDKA
                     LLVGSQPVAANEHHAILAFESNFNAGQTMKRDNLNTMFGNILSQAAGFSPEILAISME
                     EWKEVRAAFSAKAKSSQTEKEVEESLIPEGFEFLADKVKVEED"
     gene            complement(25690..26187)
                     /locus_tag="VVO18_000859"
     CDS             complement(25690..26187)
                     /locus_tag="VVO18_000859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000920162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GAF domain-containing protein"
                     /protein_id="HEU5586042.1"
                     /translation="MLKSEKQSRYQMLNEELSFLLEGETNVLANLSNASALIKSRFPN
                     TVFAGFYLFDGKELVLGPFQGGVSCIRIALGKGVCGEAAHFQETVIVGDVTTYLNYIS
                     CDSLAKSEIVVPMMKNGQLLGVLDLDSSEIEDYDTMDRDYLEQFVAILLEKTAWDFTM
                     FEEKS"
     gene            26381..27663
                     /locus_tag="VVO18_000860"
                     /pseudo
     CDS             26381..27663
                     /locus_tag="VVO18_000860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436408.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(27749..28951)
                     /gene="rpsA"
                     /locus_tag="VVO18_000861"
     CDS             complement(27749..28951)
                     /gene="rpsA"
                     /locus_tag="VVO18_000861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002897515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S1"
                     /protein_id="HEU5586043.1"
                     /translation="MNEFEDLLNSVSQVETGDVVSAEVLTVDATQANVAISGTGVEGV
                     LTLRELTNDRDADINDFVKVGEVLDVLVLRQVVGKDTDTVTYLVSKKRLEARKAWDKL
                     VGREEEVVTVKGTRAVKGGLSVEFEGVRGFIPASMLDTRFVRNAERFVGQEFDTKIKE
                     VNAKENRFILSRREVVEAATAAARAEVFGKLAVGDVVTGKVARITSFGAFIDLGGVDG
                     LVHLTELSHERNVSPKSVVTVGEEIEVKILDLNEEEGRVSLSLKATVPGPWDGVEQKL
                     AKGDVVEGTVKRLTDFGAFVEVLPGIDGLVHVSQISHKRIENPKEALKVGQEVQVKVL
                     EVNADAERVSLSIKALEERPAQEEGQKEEKRAARPRRPRRQEKRDFELPETQTGFSMA
                     DLFGDIEL"
     gene            complement(29113..29184)
                     /locus_tag="VVO18_000862"
     tRNA            complement(29113..29184)
                     /locus_tag="VVO18_000862"
                     /product="tRNA-Gln"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(29150..29152),aa:Gln,seq:ttg)
     gene            complement(29194..29274)
                     /locus_tag="VVO18_000863"
     tRNA            complement(29194..29274)
                     /locus_tag="VVO18_000863"
                     /product="tRNA-Tyr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(29238..29240),aa:Tyr,seq:gta)
     gene            complement(29324..29554)
                     /locus_tag="VVO18_000864"
     CDS             complement(29324..29554)
                     /locus_tag="VVO18_000864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000037109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2969 domain-containing protein"
                     /protein_id="HEU5586044.1"
                     /translation="MSKKDKKIEIQVADAKVNVSKDSFEGYTLTIGKKVIGEIAELDG
                     QFAIIKNGNVDSFYKKLEKAVEILIENYNLAK"
     gene            complement(29722..30366)
                     /gene="pcp"
                     /locus_tag="VVO18_000865"
     CDS             complement(29722..30366)
                     /gene="pcp"
                     /locus_tag="VVO18_000865"
                     /EC_number="3.4.19.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="HEU5586045.1"
                     /translation="MKILVTGFNPFGGEKINPALEAVKLLPSEINGAEVRWVEIPTVF
                     YKSSEVLEAEILRYQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPI
                     RIDGASAYFSSLPIKAMVQAIKKQGLPAVVSNSAGTFVCNHLMYQALYLVDKKFPNMR
                     AGFMHIPYMMEQVVNKPNTAGMSLCDIVRGIEVAIEAIVDYKDKDLQLVGGETH"
     gene            complement(30381..31304)
                     /locus_tag="VVO18_000866"
     CDS             complement(30381..31304)
                     /locus_tag="VVO18_000866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF979 domain-containing protein"
                     /protein_id="HEU5586046.1"
                     /translation="MTELAKQLLELTYIVIGCQFLHTAYCSYKDKTNPVRLGTSAFWT
                     LLSITFIGGSYMPNMSIGIIVILLSLLTLFKQVRIGTLPSLDEMKANIESNRLKNKIF
                     IPVMLMAILALVLAQMIPEFSKISISLAALFATISVLVITNSHPKSLLSENNRMTQQV
                     STSGIVPQLLGALGAIFTVAGVGDVISHLISGIVPSDSRFIGVLAYVLGMVLFTMIMG
                     NAFAAFTVITAGVGVPFVFALGANPIVAGALAMTAGYCGTLLTPMAANFNALPAALMD
                     MKDQNGVIKAQAGVALVMIVIHIFLMYFLAF"
     gene            complement(31301..31990)
                     /locus_tag="VVO18_000867"
     CDS             complement(31301..31990)
                     /locus_tag="VVO18_000867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000454813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF969 domain-containing protein"
                     /protein_id="HEU5586047.1"
                     /translation="MEWIRLIGIAIIVVGFILKFDTIATVVLAGLVTALVSGVSLVEF
                     LEILGKEFSNQRVLTIFMVTLPLVGLSETFGLKQRSIDLIRKIKGLTVGNFYTVYFFI
                     RELAGFFSIRLGGHPQFVRPLVQPMGEAAAESQLGRKLTEVEDETIKARAAANENFGN
                     FFAQNTFVGAGGVLLIGGTLDQLGYESNYAGIASTSIIVAVITLIVVGIYNYLFDKKL
                     ISKKTRGGEQK"
     gene            complement(32055..32759)
                     /locus_tag="VVO18_000868"
     CDS             complement(32055..32759)
                     /locus_tag="VVO18_000868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586048.1"
                     /translation="MVLSTSAILVACGKTDKEADAPTTFSYVYAVDPASLGYSIATRT
                     SRTDVIGNVIDGLMENDKYGNVAPSQKDYDLNSTGWAPSYQDPASYLNIMDPKSGSAM
                     KHLGITKGKDKDVVAKPGLDKYKKLLEDAVSETTDLEKRYEKYAKAQAWSTDSSLLMP
                     TASSGGFPVVSNVVPFSKPYSQVGIKGEPYIFKGMKLQKDIVTTKEYNEVFKKWQKEK
                     LESNSKYQKELEKYIK"
     gene            complement(32815..33837)
                     /locus_tag="VVO18_000869"
     CDS             complement(32815..33837)
                     /locus_tag="VVO18_000869"
                     /EC_number="2.6.1.42"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="HEU5586049.1"
                     /translation="MTVTIDWENLGFSYMKLPYRYLAHFKNGQWDQGELTEDATLHIS
                     ESSPSLHYGQQAFEGLKAYRTKDGSVQLFRPDENAKRLQRTCDRLLMPQVPTDMFVEA
                     CKAVVRANEEYVPPYGIGGTLYLRPLLIGVGDIIGVKPAEEYIFTIFAMPVGNYFKGG
                     LVPTNFLIQDEYDRAAPNGTGAAKVGGNYAASLLPGKMAKSRHFSDVIYLDPSTHTKI
                     EEVGSANFFGITADNEFVTPLSPSILPSITKYSLLYLAEHRLGLTPIEGDVPIDNLDR
                     FVEAGACGTAAVISPIGGIQHGDDFHVFYSETEVGPVTRKLYNELTGIQFGDIEAPEG
                     WIVKVD"
     gene            complement(33969..36440)
                     /gene="parC"
                     /locus_tag="VVO18_000870"
     CDS             complement(33969..36440)
                     /gene="parC"
                     /locus_tag="VVO18_000870"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit A"
                     /protein_id="HEU5586050.1"
                     /translation="MSNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
                     LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMH
                     GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFP
                     NLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAI
                     IQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
                     VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDN
                     FTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALI
                     RASENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLA
                     AIIGDERTMYNLMKKELREVKKKFATPRLSSLEDTAKAIEIDTASLIAEEDTYVSVTK
                     AGYIKRTSPRSFAASTLEEIGKRDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELA
                     DIRWKDIGEHLSQTITNFETNEEILYVEVLDQFDDATTYFAVTRLGQIKRVERKEFTP
                     WRTYRSKSVKYAKLKDDTDQIVAVAPIKLDDVVLVSQNGYALRFNIEEVPVVGAKAAG
                     VKAMNLKEDDVLQSGFICNTSSFYLLTQRGSLKRVSIEEILATSRAKRGLQVLRELKN
                     KPHRVFLAGAVAEQGFVGDFFSTEVDVNDQTLLVQSNKGTIYESRLQDLNLSERTSNG
                     SFISDTISDEEVFDAYLQEVVTEDK"
     gene            complement(36860..38803)
                     /gene="parE"
                     /locus_tag="VVO18_000871"
     CDS             complement(36860..38803)
                     /gene="parE"
                     /locus_tag="VVO18_000871"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522163.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="HEU5586051.1"
                     /translation="MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHL
                     VWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTIL
                     HAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
                     KIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDE
                     AIEFHYENGVQDFVSYLNEDKEILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVN
                     NVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYREGLAAVLSILVPE
                     EHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAA
                     RKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQ
                     AILPLRGKVVNTAKAKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDAD
                     TDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGELEE
                     LRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGD
                     KVEPRRKWIEDNVKFTLEEATVF"
     gene            38939..39580
                     /gene="plsY"
                     /locus_tag="VVO18_000872"
     CDS             38939..39580
                     /gene="plsY"
                     /locus_tag="VVO18_000872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol-3-phosphate 1-O-acyltransferase PlsY"
                     /protein_id="HEU5586052.1"
                     /translation="MITIVLLILAYLLGSIPSGLWIGQVFFQINLREHGSGNTGTTNT
                     FRILGKKAGMATFVIDFFKGTLATLLPIMFHLQGVSPLIFGLLAVIGHTFPIFAGFKG
                     GKAVATSAGVVFGFAPVFCLYLAVVFFGTLYLGSMISLSSVTASIAAVIGVLLFPLFG
                     FILNNYDPLFIAIILALASLIIIRHKDNIARIKNKTENLVPWGLNLTHQDPKK"
     gene            complement(39625..>40296)
                     /locus_tag="VVO18_000873"
     CDS             complement(39625..>40296)
                     /locus_tag="VVO18_000873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU5586053.1"
                     /translation="RVHLELRNRAYLVNHKRVQGLIKVLNLQAKMRQKRKYSSHKGDV
                     GKKAENLIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLPPVLDGFNSEIIAFNLSCS
                     PNLEQVQTMLEQAFKEKHYENTILHSDQGWQYQHDSYHRFLESKGIQASMSRKGNSPD
                     NGMMESFFGILKSEMFYGYEKSFQSFKQLEQAIIDYIDYYNNKRIKVKLKGLSPVQYR
                     TKSFG"
BASE COUNT        11946 a         8894 c         7269 g        12187 t
ORIGIN      
        1 cgagctcgtt aaatttttct gattgaattt tacgaaaatc ataaatttga cttatcgtat
       61 ttagtttttt tgcaattagc ttttgttcta gtttattagg caatacaaat gagatatctt
      121 ttattttagc tactgaaaga tgtttcactg taacaaaagg ggtcttatct tcaatttctt
      181 ttaaaaattt aggaatcaac caagatatat aaccttcatc tacactttta tccgtaattt
      241 taattttaca gacacgttga ttaagtagcg ctaaatcccc ctcccatttt ttcaatataa
      301 aactgccatc cattgtaatc aataagtctc catttttaat aagatattct tcgggataag
      361 ttccttcaaa gtaggtatca gaaaaacctc tttctacatc tcgaattcgt attaagggga
      421 gaccaatttt gttatcatta aattgtgatg atttaaaagc gtaaccagat aaaatctcac
      481 aaacttcccc caacttcact tttttcatac agccacctcc ctacttgagt aatttttcca
      541 attcagccaa gccagcttga atttcttttt ctaaatcatt gattttcttt aatatgactt
      601 ctgttggttc atactcaact ttttcatact caatctcttt atatttattg atagacaaat
      661 cataatcatt ttcctttatc tcagcaactg gaacaaagaa agattgatcc gttctctgac
      721 gttctgcttc tttttcaaga tgatgaaagc gttcgataat atctggaata tcattgtcgc
      781 taatcggttg tcgcttatca tccaaactta aaccatccgc tttcatatcg taaaaccaga
      841 ctttgtcagt accaccatta ccagtttttg taaagatgag aatggcagtt gaaactccag
      901 cataaggctt gaacacacca ctaggcattg agattacagc atcaagctta tgattctcta
      961 caatttcctg acgaattcct ttatgagctt tagacgaacc aaaaaggaca ccatcaggta
     1021 cgataactgc tgctcgtcca cctggtttta aagttcgcaa gaaaagagaa agaaagagta
     1081 attctgtttt tttggttttt acggttgcaa gaaggtcatt agaggttgaa ttgtagtcaa
     1141 gtgagccctt aaaaggagga tttgctaaaa ccaaagtata tttatcggct tcttcattat
     1201 cttgagacag cgagtcaagg taactgattt gtggattttc tactccatgt agcatcatgt
     1261 tcatcgcccc aagtctcaac atagtcgtat ccgtatcatt tccatgaaac atctgattat
     1321 gaaaatgatt gatattatct gtattggttt cccattcatc tttcttacgc tttaagtaac
     1381 ggctagcaga tactaagaag ccagcagaac ccatagcggg atctgagatg atatctttga
     1441 tagtcggttg catcaactca accatcatat cgatgatgtg acgaggtgta cggaactgtc
     1501 catttttacc tgcggtcgac aattttgata acagatattc atagatatct ccgatatcag
     1561 taatactttg tttgtcatta tcaaaatcta catctaatcc cctagttgga aaaacatcta
     1621 agatagaaat tgccttttga agcgtagcag gtttatttat ttgaaaaata gcttctcgca
     1681 tatatcgtga aaaggctgta tcatctgtat cccccttgag atttttaata aacggaaaaa
     1741 tctcctgagt cattaaacga taaacttcct gagcatctcc tatattttta aaagttgacc
     1801 aacggtattc aggtttatct tttggaaaaa ctccctcata aggaatccct agaaattcag
     1861 catcactttc acgtccaagc tcgacactat ccaaatcttt cataaataag agataagtca
     1921 actgttcaat atttgttaaa ggatttgcgt ttccttctgt ccaaagaatt tcccacagct
     1981 gatcgatttt attttttaat tcgcctgtaa tcatatcttc ccttttcttt agtttttaaa
     2041 acttagtaat atcattattt tatcagattt caaacaaagc ttcaattaac tatatctatg
     2101 cgtcacctga atattttata ctcttcgaaa atctcttcaa accacgtcag cttcaccttg
     2161 ccgtaggtat atgatactga ctctgtcagt tctatccaca acctcaaaac agtgttttga
     2221 gcaacctgcg gctagcttcc tagtttgctc tttgattttc attgagtatt aatagacttg
     2281 tttggtatcc tgaaaactat atcgtatagg tgtcgtcatg gatcctttta gctgatttaa
     2341 ggatacgaaa acacaatact atgactaaat tgaaatgtta aaattcaatt tctagccacc
     2401 taatcctgct tcaaatagtt atcgaacaag ttttatgata gctaccttgt taggatgctc
     2461 ttatttttta ccagacaaaa caaaaggatt aagggagtga atttccttaa tccgatagtt
     2521 cttattcttg acgttgtccg aaatcagcaa tcatctgatc catttcttgt cgactcggag
     2581 ttgtcagcat atacaggtaa tctccttgaa gttccgcgaa ggcagctggc atgacttttt
     2641 taaccttgaa ctgctggcta tatttggcaa gcaaatcctc ttctgaataa acatagtgag
     2701 catttgcacg gcgagaagta gccaaacaat actgagtttc aaagtctgac gccgggaact
     2761 cctctcctgc gacaatagct gcatagccac gataaaggtc caaggaatga gcaaagttat
     2821 aaacatcaat ggtaaaacca cctgcagggc ggttattgta ctcgatggta atataatcgt
     2881 ccccctcacg gaagaactca atatggaaaa accgttcttt cataccaaat tctttgacaa
     2941 ttgcttcccc atacttgcgc agtttaggat ccatatcctt gagcacataa taagaattgt
     3001 ccatcttata aatcatgagg tcaagcggtg tataggcgta gtcaaaggtt gttgagaaga
     3061 caatctttcc atccttgtcc acgagcccgt caaaggtaca gatttcgctg gaagtgacaa
     3121 atttttcaaa gaaataaagg gttgaatggt cccattcttg cttgaagtga ttgatatcgt
     3181 cttctgtctc aagtttaaag gttgcggctg ctcccactcc attatcaggt ttggcaatca
     3241 ttggaagacc gatttctttc actgcttgat caacatctgc ttccgtcttg ataacagctc
     3301 caggtaccac aggaacacct gcttttttga aaagtttctt catttcagac ttatatttcg
     3361 tctttttgag atcctctggt ttggcaccaa aaacattgaa ttgttctctg agtgttgcgt
     3421 ctagctcaag ccagtattca ttgtgagact cgatgcggtc aattggacca tgtttataaa
     3481 agagaaaagc aactgcacgt ttgacttcat ctatgttctc aagattatca acacgaaaat
     3541 actcggtcaa gctattgcgc aagggctcat ccaattgctc gtaagactct tgaccaattc
     3601 ccaagactgt gatgccttta ttagctagtt cgatggtaaa ctgttgaaag ttttgtggat
     3661 agtagggaga aataacaagg taattcatag gtaactcctt ttataaatag agattaccga
     3721 ggaaataagg catttgttta cgccaccatt cccagtcatg ggcgacatca tgtccccatt
     3781 cagcaaacca ggctggaatt tgtttcttgt caaaggcttc tttgagcttg taaaaggatg
     3841 gcaaaccatc ttgttcccag gctccaagac ccgtacacag cacaatctct gcctgacggt
     3901 aacggtcaat aaaccagccg tcgttttggt tccaaatata atctactggc gagttttggt
     3961 aaatagcatc atcgttgtag taatcaccga caaagaaacg tgcgtcgtaa acaccactga
     4021 gagcaatcac tttggtaaag acatctggat gttggaggaa gaaattgagt gcatgatagg
     4081 ctcccataga gcaacctgtc gtcatcatgc catcaaacca acctgacttg tgcttgataa
     4141 aagaatggcc tcctcaatca cataacattc gtaggcacgg tgcatttccg cttggtcatg
     4201 agcatttttc caagtagcca accagctctc actatccaaa ctagataggg taaagaactg
     4261 gacacggcct tcctcgataa aggaagcaca ggcatcaatc atgccaaaat catagtattc
     4321 gttgtgacta ccacctgatg aagcaaagac cacaactgga atcccaccat gtccataacg
     4381 gttaaggtac atttcacggt taggatgacc actccagtgg ctaagatgtt caatatgcat
     4441 ttcgtttttt cctttcttaa cttaccattt ttctgcaaaa aatctcagac aatctggtag
     4501 attttctgac caagggattt cactatggat ggcaccagac tgaactttta gcacaagatt
     4561 atccagatgt actccccctg ctatcaaatc atggtaatag caaagcgacg agtcgatata
     4621 ggcttgtttg atattgccat ccatcaaggt cttgtctgta tcatctgctt cttctgttcc
     4681 tacatagatg aagatgcgct ggtcaggcga tagtttctgg cactcgatat agcggttaaa
     4741 ggcttcttgg tggagccagt ttgcagatga aaaaacgccc aagcaaccaa tttggtcttg
     4801 gtattccaaa ccgataaact gggtaatatt gcctcctagt gaggaaccaa tcatagccgt
     4861 atgctggcag tctgcttttg tacgataggt ctcatcgata aaaggcttga ccacctccat
     4921 gacaaactca gcatactcca cacccttacc accaaactgc tgctctggga taggagattc
     4981 ttggaacttc caagccgcat actcattcat tcgccccata ccatcattgt caatagcaac
     5041 gacaatcatg cgactgatat ccggatttcg tttgatagct gggataatct tccatgaata
     5101 tccaatgaaa gactctttgc tataaaaaac attttgcccg tcatgaaagt atacaacagg
     5161 ataggaacgg tctgtatctt tctcataatc tttaggaaga agaatacgta cacggcgctc
     5221 cttacctgta taaggaacct tgagtttgtg ttctttcatt tttagataaa agtaggattg
     5281 attcattgtc agaaaactct ctatattcaa aattttatat cattatatca tgaaaataaa
     5341 aaaaaagtta gttttttacc tgtttttaga aaaaaaaact aacttttttt actgattttc
     5401 gctattcttt tggattttct gaattagagt agattatcaa tcaagtcatc aacttcatct
     5461 ttttcggctt gaggtgtgat ttcagtaatc atgattccag ccactgctcg ctcaaccaag
     5521 ccttcaacat ccatacgcgc ttcgtactgc tccgcattct taattttagg atttgttttt
     5581 ggacgatctg gtgcaaaaat ggtacaacag tcttcaaacg gttggattga aatgtcaaag
     5641 gtatcgattt cctgggcgat gtcaatgatt tccaacttgt ccatggtaac cacaggacga
     5701 atgatgggag tgttggtaac agcattgata gccttcatac tttcaagggt ttggctggct
     5761 acttgaccta gactttcccc attgatgata accaaaccat ttcgtacctc acgaatacgg
     5821 tcagtaatcc gcatcataaa gcgacgagtt agagtcatca aataagcttc tggcgctttg
     5881 gctttgattt cctcttgaat ctctgtgaaa ggcacctcga taaactggat atttccgcca
     5941 aacttggtca atttacgagt caagtcctgc gctttcttga gggcaccagg actagtatat
     6001 ggtggactag caaagtgaac tgcctcgata tccaccccac gcttaagagc aagataacct
     6061 gctacaggtg agtcaatccc tcctgacaac atgagcatcc ctttacctga agttccaact
     6121 ggcaaaccac cagccccacg aatggtttca taagaaagat aggctgcttc ttcacgaatc
     6181 tccacctgaa gattgatgtc aggacttttc atttgaactt gcacatttgg aatggcttcg
     6241 aatacagccc ctccaagtgt ttggttgagt tcacgactat caagttcaaa gttgtggtcg
     6301 ctacgcttgc tagaaatctt aaaggtcata ccttccttgt agatgtcccg cataatctct
     6361 tggacagaag acttcaaaac ttctacagat ttttcaacct tataaacagg agaaaagttt
     6421 tgaattccaa aaacttgttt gagagattct gcaactgctg tgtaatcagc tccattgagg
     6481 taagcgtggg cacggtcgcg atctgctgtt accttaactt gagtatagat agacaaaacg
     6541 tccgaaatat tattacgaag tttattgatg aaacgcatac ggtttttacc cttggttgac
     6601 aactctccgt agcgaatcat aatttctgaa tactgcatga atgctcctat cttacttttc
     6661 tagtttgatt gtaaatcaat tttaacttgg tcaaaaactg ctcgacctga ctcatatcat
     6721 tttccaagtc taggctaaga cgcacagctg acttggcctt atctttgtcc actcccatgg
     6781 caatcaaggt accagctggt tttcctgcct tagatgaaca agctgaggtt gttgagataa
     6841 aaatatcata gtcttcaaag gcgtgaacga tgacttcacc tcgaacacct ttgattccaa
     6901 aagtcagaat atgaggtgca aagtcttcct catctgaaaa gacaaaaata tccggatagt
     6961 tcagaagagc ttggtgaatc actgccttca tctgcccagt cttgctccta aagatatcta
     7021 gcttttccat agataaacga agagccttgg ctgtcgctgc aatccctgcc acattttcag
     7081 ttgtcgaacg ataatctcgc tcctggccac cacctgtaag aagaggtgta atcttcttgc
     7141 cagatttgat atagacaaag ccaacaccac ggacaccatg aaatttatga ctcgagaagg
     7201 tcgcgcaatc cacccgttct gtcagatact tttcagtcgg aattttggca agcgcctgaa
     7261 ccgcatcaac gtggaaggaa atagtcggct tgtctgccaa gaattctgaa atagcctcaa
     7321 taggttggat agagccgatt tcattgttca cagccatgat ggaaacgagg attgtatcag
     7381 gccgtatcaa acctgctaac gcctcaacat cgaccaagcc tttcttatca actggagcaa
     7441 aatccacttc aaatccttga cttttcaacc agagggctga ctctttgact gctggatgtt
     7501 caatggctga aacaatgatg tgcttgccaa actgagcttt ttcaaaggcc acacccttga
     7561 taacccagtt atccccttct gttccaccag aggtaaagaa gatttcatcg cttttcttac
     7621 cgactaaatc tgcaatctgt tggcgagaag catctaagat tcgtgttgct tggtctccca
     7681 aacgatggag actagatggg tttcctaaaa tttttgaagc gacctgcata taggtttcaa
     7741 gggcttcagg ataaggcttg gtcgtcgctg aattatcaaa gtaaatcatg tttctcacgc
     7801 tttctaaaat cactccctct attgtatcat gaaacggagc ttgcgacaag aaagggcaat
     7861 ttctcttttt ttaagatttt tttaaagaaa cagagtataa taagtcataa tcaaaggaga
     7921 gaatgtatgt ctaactatcg tagaacttca aaaccgaaaa cagaacatat caaaaaaggc
     7981 tttactgttt ttcaaaaaac cattactact atcggtagta tccttggttt gattaccgcg
     8041 ggtatcacga tcatgaacgc cttggataat aataaaaata ctaaaaaaga acctacgaca
     8101 agccagacga caacctttgt caaagaaatt caaaaagaat cccctcagga aaatactact
     8161 ccaaataagg aaaataacac ttctcaagaa aaaacacaac aagaagaaac gccaaaatct
     8221 agcgtcaagg aagagaaaaa agaagatcag aaaacagcaa ctcaggactc tactacacct
     8281 gctacaagta aacctgccac tgaaaatgaa aaacagccca atactccaac ttcagaaaat
     8341 aaaagtaatc aataaccaga aaaatagctt ccttccaacc ttggaaagaa gctatttttt
     8401 attgctgcaa tacttttctt ggcttggtac cttcagctgg accaatgaca cctgccatct
     8461 caagctcttc catgagacgg gtcgcacggt taaatccaac tgacaaacga cgctgaatca
     8521 tggatgcact ggctttctgt gtttcgataa ccaaagactt agcttcttca aaaagcggat
     8581 caccaccagc atctccatcc gaaaattctc cttcattttc agaaacctca cctggatcaa
     8641 aactctcatc gtagtctgca tctgcctgag tcttgatgaa gttcacaata cgctcaacat
     8701 cgtcatccga gataaaggag ccttggagac gaactggatg attttcatca atcggtttaa
     8761 agagcatgtc tcctcgacca agaagttttt ctgctccatt ttcatccaaa atcgtacggg
     8821 agtctgttcc tgatgaaacc gcaaatgcta cacgagatgg aacattggcc ttaatcaaac
     8881 cagagatgac atcaacagat gggcgctgag ttgcaagaat catgtggata cctgcagcac
     8941 gcgccttctg cccaagacgg atgatagcat cttccacttc cttgctggcc accatcatga
     9001 ggtcagccaa ctcatccaca atcacgacaa tgaatggtag cggaatttgc ttgtactcag
     9061 actgggaatt gaactcttct accttggcat taaaacctgc aatattccga actcccacct
     9121 tggcaaagag ttcataacgg ttttccattt catccacaac cttttgcaga gccttgctgg
     9181 ctttacgtgg attggtcaca actggaatca agaggtgggg aatatcattg taaacagata
     9241 actcaaccat cttgggatcg accatcataa atttaacttg atctggtctc gccttcatga
     9301 gaatgctagc aataatgccg ttaactgcta ctgacttccc tgaacccgtt gaacctgcaa
     9361 ctagcaagtg gggcatttta gaaaggtcaa aagctcttgc ggttccatta acagccttcc
     9421 ctaaaggaat ttccaagaaa ttttctgctt tcgtttgcga ttgttcccat agttctcgga
     9481 aagatacagt ggcaatatcg gagttgggca cttcaattcc gattagggat ttcccaggaa
     9541 ttggtgcttc aatccggaca tctttggcag ccaaggctag agcgaggtca tctgatagat
     9601 tggaaatgcg gttgaccctt acaccaacag ccggcttgac ttcatacttg gtcactgatg
     9661 gcccaatttc ggcccgttca actgttacct taataccaaa gctagcaaag gttgcttcta
     9721 agattttgat attttctctg acaattttct tctctttaga ctgatctttt ggtttatctg
     9781 gtgcaaagag ttgtaagctt ggaagtttgt attcaagggc ttctttggct gaaaaatcga
     9841 cctgaacatc ttcgtcatct gagtcatctt cctgttcagg gaatttaagt tcagtttgag
     9901 gcaggatgat ttctggttcc acccactttt cttctggaat aggtggaaga ttttgaacag
     9961 cttcctctgt cagaatttca cccgtttcca tatcaacagg aggcaaatcg agtaaggctt
    10021 tttcagtctc ttcttgttct aatctagcct ctttctcagc cttttggcga gctttttctt
    10081 cttgtttgac aaagcgttcc tcttttcgac gctcgtgccc ttcccaccat ttggcaaagc
    10141 ctctactgaa aaattcagca atatcgtaaa cagaccaagg gctgactagg agagaaccca
    10201 ctaaaatcaa gatagaacca ataaagtaag ttccgatatt tgaaaagaga aaggctgttg
    10261 gaatataaag agcgaccccg atcaagcccc ctccagcaaa gctagtcgtt cgaaaaccag
    10321 tcagatctgt cacaacctga gccatggtcc cttttagaac ggacttgtcc aaaccatatt
    10381 tccaaaccaa gtaggcttca aaaatcaaga gtaagccagc aaatatggtg aaaaagccag
    10441 ataagagtcc ttcctgtttt cgtatccact tgaaaaagaa gagatagatt aataggccga
    10501 atatcgccag ataagctagg ctacccacta gcaagcgaat taaattataa agggttatac
    10561 ctgcagcccc taatttgaag gctgcgaaaa tcaataaaat cgcaattcct aacgaaatca
    10621 acattcgttg aatcgcttct tttctttcca gttctgcttt agacggtctc cgtcttgttg
    10681 tacttgtatt cttgtttgcc attcttctat tataccatat ttcacaggca tttcgggaag
    10741 agaaaaagac tgcaccaaac ggttcaatct tttcattttt ctatttttta tgcttgtggt
    10801 ttgcgtaggt aaccataaac cacaccactt acgattgctc ctaccaagac agaaacgagg
    10861 taaaggagag catttgaagt aagggcgata acgaagattc ctccgtgtgg cgccatgagt
    10921 ttgataccag taagaccaac gagtccacct gctactgctg aaccaaggat gaagcttgga
    10981 atcgcacgag ctgggtcagc ggcaccaaat ggaatcgctc cctcagtgat aaatgacaag
    11041 cccatgatga tgtttgtcaa accagagtta cgttcttcct tagtaaattt atctttgaaa
    11101 agaagagttg cgacaaagat tgcaagtggt ggcaccattc ctccagccat aactgctgcc
    11161 atggctacag aaccacctga agaaacagtt gctgcaagcg tacctgtacc aaagacataa
    11221 gctgctttat taactggtcc acccatatca acagccatca ttccaccaag gacgatacca
    11281 agaaggacag ctgaacctcc tccaagaccg cctaggaagt cattcatagc agtgttgatt
    11341 gcagccattg ggatatttac agctagcata acaaatcctg tcaagattgt tccaagaagt
    11401 ggcaatagaa ggattgattt agcaccttcg agtgaacgag gaactttaac gtatttcttg
    11461 atggcaagaa ccaaggcacc tgcgataaat ccaccaacaa gggcacctag gaaaccagat
    11521 gagacacctg caagagttga agttgcttca ccacctgcgg cataaggaat tttaccaaag
    11581 gcaaaacctt ctttggcaat agcaccagcc acgaaacctg ctaccaaacc tggtttttca
    11641 gcaatagagt aggcaacata acccgcaaag actggaagca tcaaaccaaa ggcagctcca
    11701 ccaattttca tgaacataga agctaactca tggtaagaac caagattgcc aaggttttca
    11761 tttggaacac ccaaagcacc gtcaatcaag aaggcaaggg caatcatgat accaccaccg
    11821 ataacgaatg gtaacatttg agatacacca ctcatcaagt gtttgtagaa ggcaccacca
    11881 aggctttgtt tttcgttaga ggctgttgca gcttttgcac cattagcggc acggtagact
    11941 tcagtatctc ctgaaagagc caagttaatt agctcttctg tcttacggat accgtcagca
    12001 actggacgat tgatcaatgg ttttccatca aatcgatcca tttcaacggc cttgtctgct
    12061 gcaatgataa tagctttagc cttacggata tcttctgcag ttagttgatt tccaacaccg
    12121 ctagcaccgt tggtttcgac cttgatacca acccccattt cagcagctac tttttgaagg
    12181 gcttcttggg ccatgtaagt gtgggcaata cctgttgtac aagctgtaac agctacgata
    12241 aagtcaccag agtcattagc aggtgcttga acaagttcct cagttttttc tgaagcttgg
    12301 tcaaaaagtt cgataacttg gtctgcagat gttgcttgac gaagtttgtc tgcaaaaccg
    12361 tctttcatca agtattgaga caattctgcc aaggctgcca agtgagtatc attggcacct
    12421 tctggagctg caatcatgaa gaagaggtca gttgcttgtc catccaagct ctcgtagtca
    12481 acacccttat ttgacttagc aaatagaact gtcgcttctt tgacagcagc gtttttgctg
    12541 tgaggcattg cgattccatc acccaaacca gtagaagtca aagcttcacg cgccaaaatt
    12601 ccttctttaa atgtttcaaa atctgttaca taaccgtggt ctgtcaaatt tttaatcatc
    12661 tcgtcgatga cagctgtttt ttcagttgcc tgcaaatcta gcaacatgac atcttttctc
    12721 aataggtctt gaattttcat cgtttttcta cctcaacttt tccatatgtt tctttaataa
    12781 attccgccgt tgccaagtca tctgagaagg tagttgccgt tccgcaagcc actccccatt
    12841 tgaaggcttc tactgcgtct tttgatttga caaattcacc tgtgaatcca gcaaccatag
    12901 aatcaccagc tccaactgaa tttttgactg ttcctttgat tggtttagcg aagtaagctc
    12961 cctcagatgt gacaagaagg gcaccatcac cagccataga gataataaca ttttgagcac
    13021 ccttagccag taactcacga gcgtatttct caatttcatc taaactttcg agtttaaccc
    13081 caaaaatcgc tccaagttca tgattgtttg gttttacaag aagaggctgg tagtccaaac
    13141 tatcaattaa ggtctgtcct tcaaagtcac agaccacttg cgcaccagtc tggcgcgtca
    13201 aggaaatcaa atccttatag ataacattgc ctagattttt agcacttgaa cctgcaaaga
    13261 caactgtatc ttctgctgtc agactagata aaatagcttt caattcttct agctgaaccg
    13321 attcaacagt tggacccgtt ccgttgattt ctgtttcttg gtctgctttg attttaacat
    13381 tgatacgagt atcttctgcc acctggacaa aacgtgtctc gatttcttcc tctgctaaag
    13441 tatctgtgat aaatttacca gtaaagccac cgataaatcc cgtcgctgta tttggtatat
    13501 tcaaacgttt caagacacgg ctgacattga ttcctttccc accagcaaac ttatcatcac
    13561 tgtccatacg attgacacta ccaactttga cttggtccaa acgaacgata tagtcaatgg
    13621 atggattgag tgtgactgta taaatcatac ttctattacc tccgttttct ccttaataac
    13681 ctgcaagagc tcatgccctt gactagtgat aacgatagcg cgtttgagtg gggctacctt
    13741 ggcaaagcaa gtttgtccaa tttttgacga atccaccaag acgtaggtct gcttggcatt
    13801 ctccaaaata gctcttttca cagctccctc ctccatatca ggagtcgtat aatagccatc
    13861 gtcaacacca tttattccga taaaggcacg gtcaaagtgc aattggttaa tctggttaag
    13921 agcaacgccc ccgatactag catctgtcgc cgtcttgacg tttcctccaa ccatgacagt
    13981 tggaatctgc ttttcaacca actgagcggc atggtgaatg gagttggtca caactgtaac
    14041 attcttattg accaattcat gaatcaaaaa agcagttgtt gttccagcat cgataaagat
    14101 gacatctttt tctttaatga gagaggctgc tttctgagcc agcaatttct tttcttgaag
    14161 gtttttgaca gatttttctt gaatggtttc ttcttcctgt aaggagtagg ggagttctgc
    14221 tccaccatgc acacgacgaa gcttgttttc cgcttccaac tcatccaagt ctcttcgaac
    14281 cgttgattct gacgtttcta gcaaactaac taatttttct agagaaacta catgatgttg
    14341 atttaactcc tctaaaatta gttgtttacg ttctgttttt aacactgaat cacctcctgt
    14401 tatcgtttac actattcatt ctatcatact ttctttcgaa gtcaagcatt ttttatcatt
    14461 ttctttcaaa atctatcatt ttttcttatt tctagaattt ttattgcaag ataagagcct
    14521 ttatggtaga ctatttgagt aagtattgga agattactca agaggcttaa gaggccgtgt
    14581 tggaaacgcg gtaggcgtgt aatagcgtgc gtgggttcga atcccatgtc ttccgtcgaa
    14641 aaaagattat ttctaggatg cgacaaatgt tgtatccttt tttctatcct ttttttaaaa
    14701 tagggtctgt ttgtgactcc ctttttagca aaagaatgca aaggaatacc aaagataaaa
    14761 ataaaaaacg ttgatttaac aacgttttac caaggaatgc aaaagaatgc aaaggaatgc
    14821 aaaggaataa tggagccggt gggagtcgaa cccacgtcca aacacctgcc aacatatttg
    14881 tctacaacca taggttatgt attattttaa cagcccctcg acacataact caagtctaga
    14941 aactgcgagt ctatcaatct cttatcaagc cgctagacaa gacttaatcg tatctcgcta
    15001 ataataagac ctgtcattga acacgagcaa tccaaatcgg gtcacgcctg ctggttttta
    15061 agcagctaga gcgtaagaag tgttattttt tgcagttata tttaactgag cgtttacgtc
    15121 gccacacgag tcgcaaaata tgcctcataa tgcctgtcga atccgtaacg accccaaaag
    15181 acaataaaac cattatacct tatctaactc aaaaatgcaa aaagaaatca catacctaaa
    15241 aaagatacta ttcgagaaat ttagcaaact ggaagactaa ctacaacttt ctcagtgcat
    15301 aactttacga ttgtaaatag agcttacgaa atccaattaa cacataccta agatgaagct
    15361 atctgttttg aagaaattca cgaagagaat tattctaaaa tactttcaga tgagaatttt
    15421 cgtactctct ttattttaat tcatttgagt ttaaaaacta taaaatcaat ccttatatta
    15481 ttcggactac ttttcactta ttgcaccaaa atatagtaaa atgaaataag aataggacga
    15541 atagatcagg acagtcaaat cgatttctaa caatgtttta gaattagagg tgtactattc
    15601 tagtttcaat atactataaa taggtttcat tcgaacttta atagactatg aaaaccagtg
    15661 gaacttaccc tgacacggaa ttccactggt tttttcgatt tttatcagat taacttctac
    15721 tattcttagc tgtgaaaatt agtttaagac tttaacttat tttcagtctt ctaatctaaa
    15781 ggccacttcc agtaaagaaa aatcagggtt ctcctgactt ttacttagct aattctcttt
    15841 ctcgttcttt cattatttta tgattttcat acaaacggga taagaactta gaaatttctt
    15901 tcaagataga ataggttggc actgcgacaa tcattccaac tacaccatag atattgcttg
    15961 acaacaaaag taaaactaaa atcgtgattg gatgaacctt cataacactt cctacgattc
    16021 gaggatataa gatattgcca tctacctgct gaacaacaag catataaatc actgcaatca
    16081 gcagtctatg gggatcagtg aatatatttg cgatgatcat aggaatcaaa ccaatacttg
    16141 gccccacata aggaattaaa ttggctacac cagaaaaaat ggcaaaaact aaagcatatt
    16201 ttaaaccaat aatactatag ccaatataag ctaaacaacc tataatgatt gcgtcaatcg
    16261 aaactccact aatatagcga gcaatcgtcg catttaaatt ctttaataag cctgcaatat
    16321 gcaagcgatc cctctttaga atcgttcttt caagcatggg caagaattta tgtccatcta
    16381 ataagaaata aaccaaaaaa actggagtca taatcaaaat caaaacagta ctgataagag
    16441 ctgacaagac gctccccaca ctatttgata cgctatttag gatattttga agaatatcaa
    16501 cataggataa gtttaactgc tgaattgtag cttctacatc caaattctgg agcgcaggat
    16561 aattagataa gtctatgatt aagtcttgta ctcgactata aatagtttga ctagatataa
    16621 tcaaactaga taactgatta atcaaaatag gtaagagata gacaacacct atgaccattc
    16681 cccagaccaa agtacacaag gtaattaaaa taccaagcaa acgattgagt ttacagactt
    16741 tatttaagaa agtaacaata gggtttgtca aataataaag aaagccccct aataaaaatg
    16801 gaatcataat tgtattaagc acgctaacaa aagggttaat caaagatccc atctgtctcc
    16861 ataggtaaaa gatgatggtt aagagtaaaa tttctgtggt ccaaaaaaat aatttatttc
    16921 tacgaaacat gagttacctc cctcacttta ttttaccata ttttcaaaaa gcttaacaga
    16981 tgaattatta aagcaagaat attttttttc tttatgatag aataagacta ctatgaaaaa
    17041 aatattttta actttgttaa ctgtctctct tttagggggt gcttctactg ctgttgctca
    17101 agattttacc attgccgcta aacatgcgat tgctgttgag gcaaatactg gtaaaattct
    17161 ctatgagaag gatgcaacgc aacctgtcga aattgcttcc ataacaaaat tgattactgt
    17221 ttatctggtc tatgaagctt tggaaaacgg aagtattacc ctctccactc ctgtagatat
    17281 ttctgattat ccttatcaat tgacgacaaa ttctgaagcc agtaatattc ctatggaggc
    17341 ccgtaattat actgtcgaag agttgcttga agcaactctg gtatctagtg ccaacagcgc
    17401 cgctattgcc ctagctgaga aaattgctgg ctcagaaaaa gatttcgtcg atatgatgcg
    17461 ggcaaaactc ttggaatggg gaattcagga tgccactgtt gtcaatacga caggtcttaa
    17521 caatgaaact ctaggggata acatttaccc aggttctaaa aaagatgagg aaaataagct
    17581 tagtgcttat gatgtcgcta ttgttgctcg caacctcatc aaaaaatacc cacaagtctt
    17641 ggaaatcacc aaaaaacctt cttctacttt tgctggaatg acaatcactt caaccaacta
    17701 catgttagaa ggtatgcctg cttaccgtgg tggttttgat gggctaaaaa caggaacaac
    17761 agataaggct ggagagtctt ttgttggtac tactgtcgaa aaaggcatga gagtcatcac
    17821 agttgtttta aatgcagatc atcaagacaa taatccttac gctcgattta cagctacatc
    17881 ttccctaatg gattatattt cttctacatt tacacttcgc aaaatcgttc aacaaggcga
    17941 tgcctatcaa gatagcaaag cccctgtaca agatggaaaa gaagatacag taactgcagt
    18001 ggctccagag gatatctatc taatcgaacg tgttgggaat caatcttccc aatctgttca
    18061 attcacacct gattccaaag caatctcagc accgcttgaa gctggaacag tggttggcca
    18121 tttgacttat gaagacaagg acttgattgg tcaaggttac atcaccacag agcgccctag
    18181 tttcgaaatg gtagcagaca agaaaattga aaaagccttc ttcttaaaag tttggtggaa
    18241 tcagtttgtc cgttttgtta acgagaaatt ataaaaaatc gcgattttaa accgcgattt
    18301 tttgatacaa gttcatcttc aaaatcaaag aacaaactag gaagctagcc gcaggttgct
    18361 caaaacactg ttttgaggtt gtagatgaaa ctgacgaagt cagtaaccat acatacggta
    18421 aggcgatgct gacgtggttt gaagagattt tcgaagagta taaaatcaaa ttttatccaa
    18481 ctgatccctc catttcatag ctaatcaagc ggttcagctc aactgcgtat tccattggaa
    18541 gttcttttgt aaagggttct acaaatccca tgacaatcat ttcagttgcc tcagattctg
    18601 acaatccacg gctcatgaga taatacaatt gctcttctga aatcttagat actttggctt
    18661 cgtgttccaa agccacttgc gagttgtgaa tttcattaaa tggaatagta tctgatgctg
    18721 acaagtcatc catgataatg gtatcacatt caatgtggga aacagatttc ttagagttct
    18781 tgttaaaggt gacttgtcca cggtagtcaa cctttcctcc acctttagcg atggatttag
    18841 acacaataga cgagctggta tgtggagcat tgtgaatcat cttagcaccc gtgtcttggt
    18901 gttgccctgc attagcaaag gcgatagaga gcatggtacc acgcgctcct tctccatcaa
    18961 ggtaaacaga tggatatttc atagtcgttt tggcacccaa gtttccatca atccactcaa
    19021 cagtggcatc cttttgagcc ttagcacgct ttgttaccaa gttatagacg ttatcagacc
    19081 agttttggat agttgtataa cgcatataag ctccgtccaa agcaaaaatt tctacaatgg
    19141 cagcgtgcaa gctattgctt gaatatgttg gtgctgtaca tccttctacg tagtggacgc
    19201 ttgctccctc atcaacgata atcaaggtac gttcgaactg acctatattt tcgttattga
    19261 tacggaaata agtttgaagt ggaatatcta ccttgacacc ttttggcacg tagataaaag
    19321 ttccacccga ccatactgct gagttgaggg ctgccaactt gttatctgtc ggcggtacca
    19381 acttcgcaaa gtattgttta aataagtctg ggtattcctt gagtgcggaa tctgtatctg
    19441 taaagataat acctaatttt tggaactctt ccttcatgtt gtggtaaacc acttctgact
    19501 cgtactgggc agaagcccct gctaaataag cacgttcagc ttctggaatc ccgatacgtt
    19561 caaaggtttc tttaatcttt tcaggtacat catcccaaga acgggctggt ttgtcagatg
    19621 gtttttggta gtagattaag tcatcaaagt caatctctga caagtctgct ccccaagttt
    19681 gcatgggcat ttttttgaag gtttcataag acttcaaacg gaactccaac atccactcag
    19741 gctcaccctt aacagcagat aattcacgaa taacaccttc gttgagtcct tttcctgtcg
    19801 ataagacagg ctctacatcg tcatggaaac caaatttata ttcaccaagg tcaattggtt
    19861 ttggttctac tctttcttca gccatagtat cctttctttc ttcatttcta ataattcata
    19921 agacaaaaga aacttgtctt actgtttttc ttgattttca attgttttct taagggcatt
    19981 ccaagctagg gttgcacact tgattctttg agggaatttg gcaacacctg acaagaatgc
    20041 cgcgtctcca agttggcctt gacgctcatc tttttgccct tgaaccattt cagaaaaaat
    20101 agtcgccagt tctaaaattt cttgtttggt ttttcctaaa acggcatctg tcatcatact
    20161 agcagaagca gttgaaatcg tgcatcctga atttagaaaa gcaatatctt ccaaacggtc
    20221 ctctgcatca aacttgacag agaggttgat gacatcccca caagtcggat tgttgagact
    20281 gatttgctca gcatcttcta acttcccttg gtgatgtgga tttttcgaat ggtctgctac
    20341 cactgccata taaaggctat ctagtttaga aagtgccatt gaaaaactcc tttgtctttt
    20401 gtagggcatc gactagtttg tcgcaatctg ccttggtatt gtagatataa aaacttgcac
    20461 gagctgttgc tgggacttcc aaatactgaa gcaagggttg cgcacaatgg tgaccagcac
    20521 gaacagccac tccttcataa tccagagccg tcgcaagatc gtgaggatgg agatcaccta
    20581 ggttaaaggc aataacaccc gaacgttgag ccaaatcctg agaaccgtaa atggtcaatc
    20641 cctcaattgc ctgcagtttt ggatagacgt acgcaatcaa ttcctgttca tgagcttcaa
    20701 cggcatccat accaatcttt tccagataat caactgcagt cgcaagtcca atagctcctg
    20761 ccatatttgg cgttccagcc tcaaatttcc aaggcaattc cttccaacta gcaaattgct
    20821 cgtagacaaa atcaatcatc tcgccgccaa attctactgg agacatttgc tcaagatact
    20881 tttctttgcc gtaaaggaca ccgataccag tcggaccagc catcttgtga cccgaaaagg
    20941 cgaaaaagtc cagatccaag tcctggacat caatcttcat atgaggtgta gattgagcac
    21001 catccactac cataattgcc ccaacttggt gggctaattg agtgatttcc ttgatcggat
    21061 tgaccacacc aagaacattg gaggcatgag ctagggaaac aaatttaacc ttatcagtca
    21121 atttagctcg caaatcctcc atatccaagg caccgtcttt aagatagaca tagacaagct
    21181 ctgctccagt ctttcgacaa gcttcctgcc atggaatgat attagaatgg tgttccatta
    21241 ctgaaatcaa gacctggtct ccctcagcga gaatttcctc agcaaagcgt gccacccagt
    21301 taaggctggt tgtcgttcct ctggtaaaga gaacttcctt tgtagagcct gcattaataa
    21361 acttacgaat ggtttcacga gcagcttcat aagaagctgt cgctcgttcc gctaaggtat
    21421 ggacaccacg gtgaacattg gcattgtcct gctcatagta gctgttaata gctttcagaa
    21481 ctactagtgg tttttgtgtc gtcgcagcat tgtccagata gaccagaggt tcatcattga
    21541 caatctgatc taaaattgga aaatccttgc gaatcgcttc tacatctaac ataggcttcc
    21601 ccttagcgtt ttgacaattt ctcttcgata gttgcaatca tttcatcacg aacttccttg
    21661 actggaatct ccacgataac agatccaagg aaaccacgaa caaccaaacg ctctgcagtt
    21721 gccttatcca atccacgact catgaggtaa tacatgtctt ctggatctac ctgaccaata
    21781 gaggctgcat gtcctgcagt tacgtcattt tcatcaatca aaagaattgg gttagcatct
    21841 gaacgcgctt ggtctgaaag catgagaaca cggctctctt gttgggcatc tgctccctta
    21901 gcacccttga tgatgtggcc gataccattg aaagtcaaag ttgctttttc aaggataacc
    21961 ccatgttgta gaatgtttcc gattgagttg cagccatagt tagttacacg agtatcaatc
    22021 ccttgtacct gacgaccact tgaaagagct acaaccttga ggtcagcatg gctaccatta
    22081 ccaatcaagt cactatcaaa atcagcaacg acatttcctt cgttcatgac accgatagcc
    22141 cagtcaatac ttgcatcgtt gcctaattta ccacgacggc taatgtaggc agtgacgttt
    22201 tcacctagac ggtcgatagc agcaaacttg acttgcgcac cagaacgtgc aatcacttcc
    22261 actgtgatat tggcagttgc tttgtcactt ccttcaccgc gtgactctaa acgctccaga
    22321 taactaatct tagaattttt accagcgata atcataatat gcttgttaaa cggcacattg
    22381 ctatcgctat cttggtagaa aattccttca attggctctg taatttctac gttatctgga
    22441 atatagagta cagcaccact gttaaagtaa gctgtgtggt aagccgccaa cttgtcatca
    22501 tcatacttaa cagatgacat gaagaattct tcgatcagct ctggaatttc ttctaaagct
    22561 gagtgaaagt ctgtgaagac aacaccctgt tcagctaact caactggagt ttgttcgaaa
    22621 acagtttgag ttcctacttg caccaacttc aagtgatgat ctaaagctgt gaaatctgga
    22681 acatttgctg atggctcatt ttctgtaatc gttccatcac ccagattcca acggtggaat
    22741 ttgacacgct caataactgg taattccaaa gtctcaatct tgtcaaaagc tttttgacgg
    22801 agatcagcca accagcttgg ttcagcgtgc atttctgaaa aaagtttaat attttctcta
    22861 gtcatttact tctcctaaaa gatacgaggg aattacaatt cttccttgta gtcgtagcca
    22921 agttcttcag ctaattttgc gtatccttca cgttccaaac gcgcagccaa ttctggacca
    22981 ccagaaagga caacacgacc ttccatcatc acgtgtacca catcaggtgt gatatagttc
    23041 aaaagacgtt ggtagtgagt gatgatcata gcaccaaaac cttcaccacg catggcattg
    23101 acacctttag acacaacttt aagagcgtca atatcaagac ctgagtcaat ctcgtccaaa
    23161 agagcaaatg ttggctccaa catcaaaagt tgaagaattt cattgcgttt tttctcacca
    23221 ccagagaagc cttcgttgag gtaacgctct gccatttctt ctttcatgtt gagcaattcc
    23281 attttttcat ctagcttagt aataaactca cgaactgaaa tcttctcatc atcttcttta
    23341 cccgcattca tagcggcacg aagaaactca gcattggtaa ttccagggat ttctgatggg
    23401 tattgcatag caaggaaaag tcccatacgc gcacgctcat ccacttccaa ctcaaggatg
    23461 tttacgccat caaacaaaac ttcaccttta gttacttcat agtttggatt tcccatgata
    23521 gcggcagaaa gagtcgattt acctgtacca tttggtccca tgatagcggc aatttctcct
    23581 gttttcaggg tcaggttaac cccttttaaa atttcttttc cttcaatctc aacgtgaaga
    23641 tctttgatct ctattactga catgatagtt cctttctttt tcaaaacttt tacagtactt
    23701 actagaaaaa cgtctgattt ccccagaaat agagcaaaaa ttctataaat atacttttct
    23761 agtataacaa aaaaaagcct aaaaggcttt gattttgtct ggaagctgag ggctagtctt
    23821 tcctattaaa atgctgatcg atgacatcaa cgattttgcc catcacataa ctgactcgga
    23881 aatttctaaa tagtaaaatt gcccaaaagg ctgccataat atagcggcca gtcatccagg
    23941 cttcattgaa aaaataggtc tcagcagctg taaacagcgc cataataata aattgttgtt
    24001 tattcataaa cttattgtat catgaaatct ttctttagtc ttcctctacc ttcactttat
    24061 cagccaaaaa ttcaaatcct tctggaatca ggctttcttc tacttctttt tcagtttgag
    24121 aagatttggc tttggctgaa aaggctgcgc gaacttcttt ccattcctcc atggaaatag
    24181 ctaaaatctc aggtgaaaaa cctgccgcct gactgaggat attaccaaac atggtattga
    24241 gattgtctcg tttcatagtt tgaccagcat tgaagttaga ctcaaaagca agaatagcat
    24301 ggtgttcatt ggcagcaacc ggttgagaac caactagcag agccttgtcc ggcccaccta
    24361 gactttcaat tacctctccc caggcattct gcaaacgaat taaattttga cgtgctaaat
    24421 caggattttc gacggcctct tgtaagatag attgcacttt attgcgatcg acacgataga
    24481 ctgttttgcc cgtagctggt cgactaggag ctggtgcaac ttgtttagga accgcaccta
    24541 cattagaaag ctcttgtttg agacgggcaa cttcctgtct cagcgtagca atttcatttt
    24601 caaccgctcc tgatagagct ggttcggact tgatttccgc caaacggacg gtcatcattt
    24661 cagcataaat cttgggctgc aaactagact taatatctgc taaactcact gttgctaagc
    24721 gaatcatttc aaacagattt ttttgaggaa gtgccaaatt ttctacaaag actgaactat
    24781 gatgagtatt ttctccccct gtttgaacaa ttaacaagtc tcttaaatag tgcaaaagat
    24841 tggtcacaaa acgagtcatg ctcttaccat tgtcaaaaag aagattcaag caagacaaag
    24901 ctttgggaac atcctgttga gacaaggccg ccacataatc atccaaggct gataggctaa
    24961 tggtgccagt aatttcttca gagatagtag tcgtcagctc atttccctgt gtcaaactca
    25021 gggcttgatc caaaatagac aaggcgtccc gcattccacc ttccgcccgt ctggcaatga
    25081 tttccacagc ctctggttca gaactgatat tttctttttc taagatatag tgaatatgtt
    25141 ccttaatatc ctgtgtctta attgatttaa actcaaaacg ttgcacacgg gatagaatag
    25201 tagcaggaat cttgtgcaat tcagtagtgg ccaaaataaa gactacattc tgtgttggtt
    25261 cttccagcgt ctttaggagg gcattaaaag ctcctgtaga cagcatgtga acctcatcta
    25321 tgatataaac cttataacga gcaaggctag gcgcataggt agatttatca cgaatttcgc
    25381 gaatttcatc taccccatta ttagaagctg catccatttc aatgacatct tctaaactac
    25441 cgtccgtcac tgcttgacaa atatagcagt tattgcaagg ttcgccaccc acttgattgg
    25501 gacagttcat agccttggca aagattttag caacactggt ttttcccgtt ccacgaggac
    25561 cagaaaaaag ataagcgtga cttattttct cttgctccac cgcttgttta agagtcttag
    25621 ccacaacttc ttgaccaact aactgggaga agttttgact tctatatttt cgataaagtg
    25681 cttgatacat taagattttt cctcaaacat cgtaaagtcc catgctgtct tttcaagcaa
    25741 aatagcgaca aattgttcca aataatctcg atccatagta tcgtaatcct caatctctga
    25801 agaatccaga tccagaactc caagtaactg accattcttc atcatcggca ccacaatttc
    25861 acttttagct agactatcac aagaaatata gttgagatag gtcgtcacat ctccaacaat
    25921 aacagtttcc tgaaagtgag ctgcctcacc acaaacaccc ttgcctagtg caatacggat
    25981 gcaggaaaca cctccttgga aggggcctaa aaccaattcc tttccatcga acaaataaaa
    26041 gcctgcaaat acggtattag gaaaacgtga ttttatgaga gcactggcgt tggaaagatt
    26101 agccaaaaca ttggtttcgc cttccaatag gaaggacaat tcttcattta acatttgata
    26161 acgtgattgt ttttctgatt ttaacataga actattatat caaaaaagga gcagagacaa
    26221 aagaaaaatc ccttgtttag taaacaaagg attttgggct ctataatatt tgtagtgggt
    26281 aaatccccta tggatattat ggagcctatt ttattgtaga aaaaaagtcc catatgacct
    26341 ataatgaaaa gcgacaaaac aactcattag aaagatttat atggaacaat tacattttat
    26401 cacaaaatta ctagacatta aagaccctaa tatccagatt ttagacatca tcaataagga
    26461 tacacacaag gaaatcatcg ctaagctgga ttatgaggct ccatcttgcc ctgagtgcgg
    26521 aaatcaattg aagaaatatg actttcaaaa accttctaaa attccttatc ttgaaacgac
    26581 tggtatgcct actagaattc tccttagaaa gcgtcgattc aagtgctatc actgttctaa
    26641 aatgatggtc gctgaaactt ctatcgtcaa gaaaaatcac caaattcctc gtattatcaa
    26701 ccaaaagatt gctcaaaagt taattgaaaa gatttctatg actgatattg cccatcagct
    26761 ttccatctca acttcaactg ttattcgtaa gctcaatgat tttcacttta aacatgattt
    26821 ttcttgtctt cctgagatta tgtcttggga tgagtatgct tttacaaagg gaaagatgag
    26881 cttcattgcg caagattttg aaaagctcga tatcatcact gttcttgagg gtagaacaca
    26941 agctgtcatc cgagatcact ttcttaaata tgatagagcc gtccgatgtc gcgtcaaaat
    27001 cattactatg gatatgttta gctcttacta tgacttggct aaacagcttc gcttttaaat
    27061 ttctaggctc aggctgaaac agtctcccag actgtttcac tcccgaatgc taaaatcgtt
    27121 cttgatcgct ttcatattgt acaacatctt agccgtgcta tgagtcgtgt gcgtgtccaa
    27181 atcatgaatc agtttcatcg aaaatcccat gaatacaagg ctatcaagcg ctactggaaa
    27241 ctcattcaac aggatagccg taaactgagt gataagcgat tttatcgtcc tacttttcgt
    27301 atgtacttaa ccaataaaga gattttaaac aagcttttga gctattcaga agacttgaaa
    27361 caccactatc agctctataa taaggaacca gagaaatttt tcggacttat tgaggacaat
    27421 cttaagcagg ttcatcctct ttttcagact gtctttaaaa cctttctaaa ggacaaagag
    27481 aaaatcgtca acgcccttca actaccctat tcaaacgcca aattggaagc gaccaataat
    27541 ctcatcaaac ttatcaagcg caatgccttt ggttttcgga actttgaaaa cttcaaaaaa
    27601 cggattttta tcgctctgaa catcaaaaaa gaaaggacga aatttgtcct ttctcaacct
    27661 tagcttttct tcaacccact acagttgaca aagagccaga aaaatccctt gtttagtaaa
    27721 caaaggattt tgtgaatttt caatttgatt aaagttcgat atcaccaaac aaatcagcca
    27781 ttgaaaatcc tgtttgtgtt tctggaagtt cgaaatcacg cttttcttga cgtcttggac
    27841 gacgtggacg agcagcacgt ttttcttctt tttgtccttc ttcttgggct ggacgttctt
    27901 caagagcttt aatagaaagt gacacgcgtt ctgcatctgc gttaacttca agaactttaa
    27961 cttgaacttc ttgaccaact ttaagagctt cttttggatt ttcaatccgt ttgtgtgaaa
    28021 tttgtgatac gtgaacaagt ccatcgatac ctggcaatac ttcaacaaat gcaccgaagt
    28081 cagtcaaacg tttaactgtt ccttctacta catcaccttt agccaatttt tgctcaacgc
    28141 catcccatgg tcctggtact gttgctttaa gtgaaagtga tacacgtcct tcttcttcgt
    28201 taagatcaag gattttcact tcaatttctt caccaacagt tacaactgat tttggtgata
    28261 cgttacgttc atgtgacaat tcagtcaagt gaaccaatcc gtcaacacca ccaaggtcga
    28321 tgaaagcgcc gaagcttgtg atacgagcaa ctttaccagt tacaacatca ccaacagcca
    28381 atttaccgaa tacttcagcg cgagctgctg cagtagctgc ttcaacaact tcacgacgtg
    28441 aaaggatgaa acggttttct ttagcgttaa cttctttgat tttagtatca aattcttgac
    28501 ctacaaaacg ctcagcgtta cgtacgaaac gagtatccaa cattgaagct gggataaatc
    28561 cacgaacacc ttcaaattct actgaaagtc cacctttaac ggcacgcgtt cctttaacag
    28621 taacaacttc ttcttcgcga ccaacaagtt tgtcccatgc tttgcgagct tcaaggcgtt
    28681 ttttagatac aaggtatgta actgtatcag tatctttacc aactacttga cgaagtacaa
    28741 gaacatccaa tacttctcct actttaacaa agtcattgat atctgcatca cgatcgtttg
    28801 tcaattcgcg aagagtcaag acaccttcaa caccagttcc agagattgca acgttagctt
    28861 gagtcgcatc aactgtcaat acttcagcac taacaacatc accagtctca acttgactaa
    28921 cgctatttag caaatcttca aattcgttca tctaaaaaat cctccaacaa tcaagttttt
    28981 cttaaacttg acatacttat aatttttttc ctaagcaccc gcaaggacat gttcatatca
    29041 ttcacgtctt tcaattataa aaataaaata ccctaagata ttttgctttt tatcttgatt
    29101 attacctaag aactggggta gctggattcg aaccaacgca tgagggagtc aaagtccctt
    29161 gccttaccgc ttggctatac cccattaatg aaatggagag agagggattc gaacccccga
    29221 acccgaagga gcggatttac agtccgccgc gtttagcctc ttcgctatct ctcctacaat
    29281 caacatggac tattatatca tgaaaatttc aaaaaaacaa gacttatttt gctaaattat
    29341 aattttcaat caaaatttcc acagcttttt ccaatttttt ataaaaacta tcgacattcc
    29401 cattctttat aatggcaaat tgtccgtcta attcggcaat ttctccgata acttttttac
    29461 cgatagtcaa tgtataacct tcaaaactgt ctttactaac attaactttg gcatccgcta
    29521 cttgaatttc gattttttta tctttcttgc tcatttcata cctctcttca ctttttctat
    29581 tttacaagaa aatcctaaaa ctagcaagaa aaaactctat atcaggcttc tctgatatag
    29641 agttttatgt aaacaacctc aattgattta gcatagttaa tagttagtaa acaagcataa
    29701 ttgactatcc tttttaggtt atcagtgagt ctcaccgcct actaactgca aatccttatc
    29761 tttgtagtct acaatagctt caatagctac ctctatgcct cttacaatat cacatagact
    29821 cattcctgca gtattcggct tatttactac ttgttccatc atatatggaa tatgcatgaa
    29881 acctgctctc atattaggga attttttatc cactaaataa agagcttggt acatcaaatg
    29941 attgcaaaca aaggttcctg cactattgga tacaactgcc ggaagtccct gttttttgat
    30001 agcttgtacc atcgctttga taggtaaact actaaaatag gccgatgctc catcaatacg
    30061 aatcggtgta tcaattggtt gattgccttc gttatcaggt atgcgagcat catcttgatt
    30121 aatagccact cgttcaggtg ttaagccggt cctgccgcct gcttgtccaa tacaaagtac
    30181 agcatctggt tgatatcgta atatttctgc ctctaaaact tctgacgact tataaaaaac
    30241 cgttggaatt tctacccagc gaacttcagc cccattaatc tcagatggta ataattttac
    30301 agcctccaaa gctggattaa tcttttcacc tccaaaagga ttaaaacctg taaccaatat
    30361 tttcatttta ttttccttta ctaaaatgcg agaaagtaca ttaagaatat gtgaataaca
    30421 atcattacta gagcaacacc tgcttgagcc tttataacgc cattctgatc tttcatatcc
    30481 atcaatgctg ctggtagagc gttaaaatta gcagccattg gggtcaataa ggtcccacaa
    30541 taacctgctg tcatggcaag agcaccagcc acaattggat tagctcccag agcaaataca
    30601 aagggaactc caacacctgc tgtaataacg gtgaatgctg caaaagcatt tcccataatc
    30661 attgtgaata gaaccattcc aagaacatag gccaaaactc ctataaagcg actatctgaa
    30721 ggaacaatac cgctaatcag atgagagata acatcaccaa cacctgctac agtaaaaata
    30781 gcccccaaag cccctaataa ttgaggaaca atcccacttg ttgaaacttg ctgagtcatt
    30841 cgattatttt ctgataacag actcttaggg tgactattgg taatcacaag aacagaaatt
    30901 gtagcaaaca aggcggcaag gctaatcgaa atcttgctaa attctggaat catttgcgct
    30961 aagaccaacg caagtattgc catcagcata actggaataa aaattttatt tttcaacctg
    31021 ttagattcaa tattggcttt catttcatct aaggatggca aggttccgat acggacttgc
    31081 ttaaacaatg ttaacagcga taataggatt acaataatac caatactcat atttggcata
    31141 taggaaccac ctataaacgt aatagacaat agagtccaaa atgcagatgt cccaagtcga
    31201 actgggtttg ttttatcttt ataactacaa taggctgtat ggagaaattg acaaccaatc
    31261 acaatatagg tcaactctaa tagttgcttt gccaactctg tcatttttgt tctcctcccc
    31321 tagtcttttt tgatatcaat tttttatcaa ataaataatt gtaaatcccc actacaataa
    31381 gtgttataac agcaacaata atagatgtag aagcaatccc tgcataattg ctttcatagc
    31441 ctaactgatc taatgttccc cctatcaaga ggactccccc agcacctaca aacgtatttt
    31501 gagcaaagaa atttccaaaa ttttcattcg cagccgcacg cgcttttatt gtctcatctt
    31561 caacctctgt taactttcta cctaattgag actctgcagc tgcttctccc ataggttgaa
    31621 ccaaaggtct gacaaactga gggtgtcctc ctagacgaat tgaaaagaaa ccagctaact
    31681 ctcgaataaa gaaataaact gtatagaagt ttccaactgt cagaccttta atctttcgaa
    31741 tcaaatcgat tgatcgttgc ttgagtccaa aggtttctga cagccccaca agaggcaagg
    31801 taaccataaa aatcgtgagc actcgctgat tgctaaattc ttttcccaaa atctccaaaa
    31861 attcaacgag agaaacacct gaaactaaag ctgtaaccaa accagctaag actactgttg
    31921 caattgtatc aaattttaaa ataaaaccca caacaatgat tgctattcct attaatctaa
    31981 tccactccat atcaaactcc tttatattca aaatgacagt attttaaaaa ttttatcaag
    32041 atcaatacca ttccttattt aatgtatttt tctagttctt tttggtattt gctattggat
    32101 tccaattttt ctttttgcca ttttttaaaa acctcgttat attcttttgt tgtaacaata
    32161 tctttttgca atttcattcc tttaaagata tatggttccc ccttaatacc aacttgtgag
    32221 tatggttttg agaatggtac tacgttactt acaactggaa aaccaccaga tgaagctgtt
    32281 ggcatcaata atgaactatc tgtcgaccaa gcttgagctt tggcatattt ttcatatctc
    32341 ttctctaggt cagtggtctc agaaacagca tcttctaaca atttcttata tttatccaaa
    32401 ccaggtttag ctacaacatc cttatctttt cctttcgtaa tgccaaggtg tttcatggca
    32461 gaaccagatt ttggatccat aatattcaag taagacgctg gatcttgata gcttggagcc
    32521 catcctgtac tgttcaaatc atagtctttt tgagaaggag caacattgcc gtatttatca
    32581 ttttccatca aaccatcaat aacatttcca ataacgtctg tcctcgatgt tcgagtcgct
    32641 atactgtagc ccaatgatgc tggatctact gcatagacat aagaaaatgt tgtcggtgca
    32701 tctgcttctt tatcagtttt tccacaagcc actaaaatag ctgacgtgct caggaccact
    32761 cctgctgtta agagccactt tttctatttc ataaaaaatc tcctttggtt tattttaatc
    32821 tacttttaca atccaacctt ctggcgcttc aatatcgcca aactgaatac ccgtcaattc
    32881 attatataat ttacgcgtca caggacctac ttctgtttca ctatagaata catggaaatc
    32941 atcaccatgt tgaatacctc caattggaga aataaccgct gctgtaccac aggcacctgc
    33001 ctctacaaaa cggtcaagat tatcaattgg aacatcaccc tcaataggag ttaatcccaa
    33061 gcgatgttct gccaaataaa gcaaggaata cttggtaata gatggcaaga tagatggact
    33121 caatggtgtt acaaattcat tatcagctgt aattccaaag aagttagctg atccgacttc
    33181 ttcaatcttt gtatgagttg atgggtccag atagataaca tctgagaaat ggcgtgactt
    33241 ggccattttt cctggtaaga gacttgcagc atagtttcca ccaaccttag ccgcacctgt
    33301 accatttggt gctgcacggt cgtactcatc ctgaatcaag aaattggttg ggaccaaacc
    33361 acctttaaag taatttccaa ctggcatagc aaagatggtg aaaatgtact cttctgccgg
    33421 ttttaccccg ataatatctc cgacaccaat caaaagaggg cgaagatata aggttccacc
    33481 tattccgtat ggtggtacgt attcttcatt cgcacggaca actgctttac aagcttctac
    33541 aaacatgtct gtcggaactt gtggcatcaa gagacggtca catgtacgtt gcaggcgttt
    33601 agcattttca tcaggacgga acagttgaac actgccatcc ttagtacgat aagctttcaa
    33661 accttcaaat gcttgttgtc catagtgaag acttggagaa gactctgaaa tatgcaaagt
    33721 tgcatcctct gtaagctctc cttgatccca ttgtccattt ttgaaatgag caagatagcg
    33781 ataaggtaat ttcatatagg aaaaaccgag gttttcccaa tcaatcgtta ctgtcatatt
    33841 ccactcctta ttctaaaaac ctatttctta tattctacac tatttttcta aaatagcaag
    33901 tatattttgt aattttcaga aaatttctcc aataaaaacc agctcttaga actgattctt
    33961 catttcactt atttatcttc agtaactact tcctgaagat aagcgtcaaa aacttcttca
    34021 tctgaaatcg tgtcagaaat gaagcttcca ttgctagtgc gttctgacaa gttcaagtct
    34081 tgcaatcggc tttcatagat tgttccttta ttggattgga caagcagagt ttggtcgttc
    34141 acatccactt ccgtactgaa gaaatcgcca acaaatcctt gctctgcaac tgctcctgcc
    34201 aagaagacac gatgcggttt gtttttcaac tcacgcaaga cttgtaatcc tcgtttggca
    34261 cggctggttg ctagaatttc ctcaatggaa acacgtttca agcttccacg ctgggtcaag
    34321 aggtagaagg acgaagtatt acagataaag ccagattgga ggacatcatc ttctttcaaa
    34381 ttcatagcct tgacacctgc tgccttagca ccgacaaccg gaacctcttc gatattgaaa
    34441 cgcagggcat aaccattttg actaaccaag acaacatcat ctagtttaat cggagccact
    34501 gctacaatct gatctgtatc gtctttgagc ttagcatact tgacagactt agatctatag
    34561 gtccgccatg gagtgaattc ttttcgctct acccgtttga tttgaccaag gcgagtcact
    34621 gcaaagtagg ttgtcgcatc gtcaaactga tccagtactt ccacataaag gatttcttca
    34681 ttcgtttcaa agtttgtgat ggtttggctc agatgctctc cgatgtcctt ccaacgaata
    34741 tctgccaact catggattgg tctgtagatg acatttccaa gacttgtgaa catcaagagg
    34801 tgctgggttg tcttggcaga ttgaacaaaa atcaaacggt catcatcacg cttgccaatt
    34861 tcttccaagg tggaagccgc aaaggaacgt ggactggtac gcttgatgta acctgccttg
    34921 gtcacgctga cgtaggtatc ttcctcagcg ataagactag ctgtatcaat ctcaattgct
    34981 ttcgcagtgt cttctaaaga actcaaacga ggagttgcaa atttcttctt gacctcacga
    35041 agttctttct tcatgagatt gtacatagtc ctttcatcac cgataatagc cgccagcata
    35101 gcaatcttct cacgaagctc tgcttcttct tcctgcaaga caaccacatc ggtattggtc
    35161 aaacggtaca gttgcaaagt tacgatagcc tcagcctgtt cttccgtaaa atcatagcta
    35221 actttgaggt tttccttggc gtccgcctta ttctcagaag cacggataag agcaatgact
    35281 tcatccaaaa tcgaaatcac acgaatcaaa ccttcgacga tatggagacg tttctcagcc
    35341 ttttctttgt caaagcgtga acgcgccaaa atcacttctc gacggtgagc gatgtagcta
    35401 gacaggattg gaacaatccc aacctgacga ggtgtgaaat tgtcaatcgc caccatatta
    35461 aagttgtagt tgatttgtag gtcggtgtac ttaaataagt agttgagaac aagctcagta
    35521 ttagcgtctt tcttaagttc gatagcgata cgaagaccat cacggtcaga ctcatcacga
    35581 acctcagcaa tcccagctac cttgttatta acacgaacat catcgatttt cttgactaga
    35641 ttggccttat tgatttcata aggaatctca gtaataacga tttgttcctt accacctttt
    35701 agcttttcaa tttcagtctt ggaacgaaca accacgcgcc ctttcccagt ctcataagct
    35761 ttcttgattt catcacgacc ctgaataata gcccctgtag ggaagtctgg tccaggcaag
    35821 aattccatga gtttatcaat ctttgcagtt gggtggtcaa tcatgtaaac tgcagcatct
    35881 atgacctcag ctaaattatg gggaggaatg tctgtggcat aaccagccga aatcccagtc
    35941 gaaccattga ccaagaggtt tggaaaggct gctggcaaga ccgttggttc tttctccgta
    36001 tcgtcaaagt tccatgcaaa aggaactgtc tttttctcga tatcctgaag aaggtagcct
    36061 gcaatttcag acaaacgtgc ctcagtataa cgcatagccg caggaggatc tccgtccata
    36121 gaaccgttat taccgtgcat ttcaactaga atctcacgat ttttccagtt ctgtgacata
    36181 cgaaccatgg catcatagat agaagaatcc ccgtgtgggt ggaaattccc catgatgttc
    36241 ccgactgact tggccgactt acggtagctc ttgtcaaaag tattgctatc cttattcata
    36301 gaataaagaa tacggcgctg aaccggcttc aacccatcac gaatatctgg caaagcccgg
    36361 tcttgaataa tgtacttgga gtagcgacca aagcgctctc ccatgatgtc ctccagggac
    36421 atgttttgaa tgttagacat aagatacaaa gcccataaaa taccaagtga aaatagaaaa
    36481 ttcttgaagt aagcaaactc acaagagaat ttatcttttt cacacagtat ctagggcgtg
    36541 ttcaactcct ttcaaagaat gtagagtagg tttttatgca gtaaaagata ttttacggga
    36601 attcgtcccg tgttcagtta cgataagtaa ccaaactatc ctgtttgtat ttttcaatat
    36661 gaaaatatgg ttttccaaaa ttagtcttag tttgtgtctt agccgctccc ttaaacgcct
    36721 ctttgagata agcactcata gcagattctt cattaataat cctgcaattt tttcaaacca
    36781 agattttcaa actgcttttt cacatagtca ttcacatccg actctaattt ccagtttact
    36841 aacatattat tttctttcat taaaacactg tcgcttcttc tagcgtaaac ttgacattat
    36901 cttcaatcca tttacggcgt ggttctacct tatctcccat gagaacattg acgcggcgtt
    36961 cggcgcgcgc taaatcttca attgtgacac ggatgagggt acgtgtttct gggttcatgg
    37021 ttgtttccca gagctggtcc gcattcatct caccaagtcc tttgtatcgt tggagggtag
    37081 cgcctttacc gaactgttta cggagttctt ctagttctcc gtccgtccaa gcgtaggcca
    37141 cttcttcttt cttgccttta cctttggaca tcttgtaaag aggtgggagg gcaatataga
    37201 catgacctgc ctcgactagc ggacgcatgt aacggtagaa aaatgtcaag agcaaggtct
    37261 ggatatgggc accgtcggta tccgcatcgg tcatgataat gatcttatca tagttggcat
    37321 cttcaataga gaagtctgct ccaacacccg caccaatggt ataaatcatg gtattgatct
    37381 cttcattttt gaggatatcc gccatcttgg ccttggctgt attgacaacc ttaccacgaa
    37441 gaggtagaat agcctggaac ttgcggtcac gaccttgttt ggcagaacca ccggcagagt
    37501 ccccctcaac tagatagagt tcattcttag caggattctt agattgggct ggggtcaatt
    37561 tcccagacaa caagccctta tctttcttgt ttttcttccc atttcggctc tcatcacgcg
    37621 ccttacgtgc tgcttcacga gcatcacggg ccttgatagc cttgcggatg aggttagaag
    37681 ctaattcccc attttccata aggaaaaagg tcaacttatc agccactatt ccatccacaa
    37741 ctgggcgagc tagggggctt cctagtttat ccttggtctg tccttcaaac tgcaagtgtt
    37801 cttcaggaac taagatagaa agaacggccg ctagtccctc acgatagtct gaaccttcaa
    37861 ggtttttatc tttttccttg agaagacctg ttttacgtgc atagtcattc atgaccttgg
    37921 taatggcaga cttgagtcct gtctcgtgcg ttccaccgtc cttggtgcga acgttattga
    37981 caaaggatag aatgttatct gagaatccgt cattgtactg gagggctact tccacttgaa
    38041 aaccattgtc ttccccttca aagtaaagaa ctggcgtcaa gatttcctta tcttcgttga
    38101 gataagaaac aaaatcttgt actccattct catagtggaa ctcaatcgct tcatctgttc
    38161 gcttgtccgt taaagacaag gtcacatttt tcaagagaaa ggctgattca ttaaggcgct
    38221 ctgaaatggt attgtacttg aaatctgtcg tagaaaagat agtcgcgtca ggcataaaag
    38281 taactttggt gcctgtttta gacttgggtg ctgtaccgat tttcttcaaa gtcgtgacag
    38341 gttttccacc attttcaaaa cgttgcttgt aaactgcgcc atcacgggta atttcaactt
    38401 ctaaccagct agaaagggcg ttaacaacgg aagaacccac tccgtgaagt ccacctgatg
    38461 tcttatagcc accttgaccg aatttccctc cggcatgaag aatggtaaag ataacctcaa
    38521 cagttggaat tcccatagcg tgcatacctg tcggcatccc acgtccatgg tcttgaaccg
    38581 ttagactacc gtctttattg atggttacat cgatacgatc accaaaccca gacaaggctt
    38641 catcgactgc attatcaacg atttcccaaa ctaggtgatg aagaccagcg ccatcggtcg
    38701 atccaatata catccctgga cgttttcgga ccgcatccaa cccttctagc acctgaatag
    38761 catcatcatt ataattgtta atattgattt ccttttttga cacaaggaac ctcctattcg
    38821 ttcatcttta ctattctaca ggttttccaa ggattttgca aaatttttct ttctccgatg
    38881 tgacaatttt agcagagatt ctctgctttt ctttcccaat tcatgatata ataggagtat
    38941 gattacaata gttttattaa tcctagccta tctgctgggt tcgattccgt ctggtctctg
    39001 gattggacaa gtattctttc aaatcaatct gcgtgaacat ggttctggaa ataccggaac
    39061 gaccaatacc ttccgcattt taggcaagaa agctggtatg gcaacctttg tcattgactt
    39121 tttcaaagga accctagcaa cgcttcttcc gattatgttt catctacaag gcgtttcgcc
    39181 tctcatcttt ggacttttag ctgtaatcgg ccataccttc cctatctttg caggatttaa
    39241 gggtggtaag gctgtcgcaa ccagtgctgg agtggttttc ggatttgcgc ctgtcttctg
    39301 tctctacctt gcagttgttt tctttggaac cctctatcta ggcagtatga tttcactttc
    39361 cagtgtcaca gcatctatcg cggctgtcat cggagttcta ctctttccac tttttggttt
    39421 tatcctgaac aactatgacc ctctcttcat cgctattatc ttagcacttg ctagtttgat
    39481 tatcattcgt cataaggaca atatagctcg tatcaaaaat aaaactgaaa atttggtccc
    39541 ttggggattg aacctaaccc atcaagatcc taaaaaataa aatgccagtt ctgtgaactg
    39601 caccccaaaa gttagacaat taatttatcc gaaggattta gttctgtatt gcacagggct
    39661 aagtcctttt agttttacct taattcgttt attgttgtag taatcaatat agtctataat
    39721 agcttgttcc aattgcttaa acgactgaaa cgacttctca taaccgtaaa acatttccga
    39781 tttcagaatc ccaaagaagg actccatcat accattgtct gggctgttac ccttacgtga
    39841 catggatgct tgaattccct tactctctag gaaccgatga taagaatcgt gttgatattg
    39901 ccagccttgg tcactatgga gaatcgtatt ctcgtagtgc ttctctttga atgcctgttc
    39961 caacattgtt tgtacttgtt ctaaattagg cgaacaagaa agattaaaag caataatttc
    40021 actgttaaag ccatctaaaa ctggtggtaa gtaaagcttt tgagtacttg ctggaatggc
    40081 aaattctgtc acatctgtgt agcacttttc cattgtttta gagccttcaa attggccttg
    40141 aatgagattc tctgccttct tgccaacgtc tcctttatga gaagaatatt ttcgtttctg
    40201 tcgcatttta gcttgtaaat tgagtacttt tatcaagcct tgaactcttt tatgatttac
    40261 cagataagca cgatttctta gttctaaatg aacccg
//
LOCUS       DAVHIZ010000017        34471 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.017, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000017 DAVHIZ010000000
VERSION     DAVHIZ010000017.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34471)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34471)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34471
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.017"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            115..1461
                     /gene="celB"
                     /locus_tag="VVO18_000874"
     CDS             115..1461
                     /gene="celB"
                     /locus_tag="VVO18_000874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIC"
                     /protein_id="HEU5586054.1"
                     /translation="MDQQNGLFGFLENHVMGPMGKLAQFKVVRAITAAGMAAVPFTIV
                     GSMFLVFSILPQAFSFWPIVADIFSASFDKFTSLYMVANYATMGSLSLYFVLSLAYEL
                     TKIYAEEEELNMNPLNGALLALMAFVMTVPQIIFDGGMMKTVTSLKEGAVIADGWAMG
                     NGVARFGTTGIFTAIIMAIVTVLIYRMCVKHNWVIKMPEAVPEGVSRGFTALVPGFVV
                     AFVVIFINGLLVAMGTDIFKVIAIPFGFVSNLTNSWIGLMIIYLLTQLLWIVGIHGAN
                     IVFAFVSPIALANMAENAAGGHFAVAGEFSNMFVIAGGSGATLGLCLYIAFASKSEQL
                     KAIGRASVVPALFNINEPLIFGLPIIYNPALAIPFILAPMVTATIYYVANSLNFIKPI
                     IAQVPWPTPVGIGAFLGTADLRAVLVALVCAFAAFLVYLPFIRVYDQKLVKEEQGI"
     gene            1842..2018
                     /locus_tag="VVO18_000875"
     CDS             1842..2018
                     /locus_tag="VVO18_000875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866213.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586055.1"
                     /translation="MSLDIDKEKMTIMGIAFENRSVFKSVWYALSTNMIEGWRPTVSD
                     VEKLRDEALALGMT"
     gene            2419..4632
                     /locus_tag="VVO18_000876"
     CDS             2419..4632
                     /locus_tag="VVO18_000876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000688702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-xylosidase"
                     /protein_id="HEU5586056.1"
                     /translation="MKIFKGEFYRISVLTDKLVRLEYSRTGNFEDRTTQLIYNRDFGQ
                     VSLDYIETSNVLDIMTDYFHLHFNKGEFNAENLFIELKGNFAVYGSRWYFGESIETLK
                     GTARTLDKADGAISLEDGIISRNGIALLDDSQGFIWDEQSGYIERENQIDLYFFAYGH
                     DYRGAIRDFYHLTGSIPLLPRYALGNWWSRYWPYTSDEYLDLIDRFETEKIPLSIGVL
                     DMDWHITDIPARFGSGWTGYSWNRNLIPNPEQLLQQLHDRKLKLSLNVHPADGIRAYE
                     EAYPQIAKRLGLNVELEEPAIFDFFNPSFREAYFKDVHYELEKQGVDFWWIDWQQGTQ
                     GMLDPLWLLNHYHYQDSCKNAEGGLILSRYAGPGSHRYPVGFSGDTIISWNSLRFQPY
                     FTATASNIGYSWWSHDIGGHMLGDYDEELQTRWLQFGVFSPITRLHSSRSPFNSKEPW
                     FFSETTSKIMKKYLRLRHQMIPYLYTMNVQTHEEGAPLISPIYYFYPENDESYNVPNQ
                     YFFGTELMVAPIVEKMDLTFQSAKVDVWFPEGEWYDFFSEKKYTGGVKLSVYRDISTT
                     PVFAKSGAIIPLVGSEIDMGVDLPEVVDWYVFPGKQHYFEMLEDQNGQRYKTRLSIDW
                     EMGMVELALQGDSSIVPSNRKHRIHFKGTNVSIIELPNKNDTAKFEWKDNKRTSLNDE
                     VFRLLKTASLPYELKDRLLNQFINAKNSHDLMNILHHQDKELRGRLLEMIFTSQN"
     gene            complement(4854..5330)
                     /locus_tag="VVO18_000877"
     CDS             complement(4854..5330)
                     /locus_tag="VVO18_000877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398949.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione peroxidase"
                     /protein_id="HEU5586057.1"
                     /translation="MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQG
                     LQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKE
                     ADPLYVWLKDHKSGPLGKRIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL"
     gene            5553..8756
                     /locus_tag="VVO18_000878"
     CDS             5553..8756
                     /locus_tag="VVO18_000878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001193686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored hyaluronate lyase"
                     /protein_id="HEU5586058.1"
                     /translation="MQTKTKKLIVSLSSLVLSGFLLNHYMTVGAEETTTNTIQQSQKE
                     VQYQQRDTKNLVENGDFGQTEDGSSPWTGSKAQGWSAWVDQKNSSADASTRVIEAKDG
                     AITISSPEKLRVAVHRMVPIEAKKKYKLRFKIKTDNKVGIAKVRIIEESGKDKRLWNS
                     ATTSGTKDWQTIEADYSPTLDVDKIKLELFYETGTGTVSFKDIELVEVADQPSEDSQT
                     DKQLEEKIDLPIGKKHVFSLADYTYKVENPDVASVKNGILEPLKEGTTNVIVSKDGKE
                     VKKIPLKILASVKDAYTDRLDDWNGIIAGNQYYDSKNEQMAKLNQELEGKVADSLSSI
                     SSQADRIYLWEKFSNYKTSANLTATYRKLEEMAKQVTNPSSRYYKDETVVRTVRDSME
                     WMHKHVYNSEKSIVGNWWDYEIGTPRAINNTLSLMKEYFSDEEIKKYTDVIEKFVPDP
                     EHFRKTTDNPFKALGGNLVDMGRVKVIAGLLRKDDQEISSTIRSIEQVFKLVDQGEGF
                     YQDGSYIDHTNVAYTGAYGNVLIDGLSQLLPVIQKTKNPIDKDKMQTMYHWIDKSFAP
                     LLVNGELMDMSRGRSISRANSEGHVAAVEVLRGIHRIADMSEGETKQRLQSLVKTIVQ
                     SDSYYDVFKNLKTYKDISLMQSLLSDAGVASVPRTSYLSAFNKMDKTAMYNAEKGFGF
                     GLSLFSSRTLNYEHMNKENKRGWYTSDGMFYLYNGDLSHYSDGYWPTVNPYKMPGTTE
                     TDAKRADSDTGKVLPSAFVGTSKLDDANATATMDFTNWNQTLTAHKSWFMLKDKIAFL
                     GSNIQNTSTDTAATTIDQRKLESGNPYKVYVNDKEASLTEQEKDYPETQSVFLESSDS
                     KKNIGYFFFKKSSISMSKALQKGAWKDINEGQSDKEVENEFLTISQAHKQNGDSYGYM
                     LIPNVDRATFNQMIKELESSLIDNNETLQSVYDAKQGVWGIVKYDDSVSTISNQFQVL
                     KRGVYIIRKEGDEYKIAYYNPETQESAPDQEVFKKLEQATQPQVQNSKEKEKSEEEKN
                     HSDQKNLPQTGEGQSILASLGFLLLGAFYLFRRGKNN"
     gene            9104..9468
                     /gene="tnpA"
                     /locus_tag="VVO18_000879"
                     /pseudo
     CDS             9104..9468
                     /gene="tnpA"
                     /locus_tag="VVO18_000879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011148688.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
     gene            complement(9857..10486)
                     /locus_tag="VVO18_000880"
     CDS             complement(9857..10486)
                     /locus_tag="VVO18_000880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000167291.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="HEU5586059.1"
                     /translation="MTKSDTIIELKKQKIVAVIRGNTKEEGLQASIACIKGGIKAIEI
                     AYTNQYAGQIIKQLVDLYQDDQSVCIGAGTVIDAVTARDAILAGANYVVSPSFHAETA
                     KMCNLYSTPYIPGCITLTEITTALEAGSEIIKLFPGSALSPAYISAVKAPIPQVSVMV
                     TGGVGLNNIPQWFAAGADAVGIGGELNKLASQGDFDRISEIAQQYVTLR"
     gene            complement(10496..11497)
                     /locus_tag="VVO18_000881"
     CDS             complement(10496..11497)
                     /locus_tag="VVO18_000881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730651.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar kinase"
                     /protein_id="HEU5586060.1"
                     /translation="MTKILLFGEPLIRISPLDATSIGDHVASSTYFGGSEINIACNLQ
                     ALGISTKVFTALPANEIGDRFLTFLKQHQIDTSSICRLGDRIGLYFLENGFGCRQSEV
                     FYDRKHTSISQIRPNMLDMGSLFQGISHFHFSGITVAIGQEVRTLLLLLLEEAKRRGI
                     IVSMDLNLRTKMISVLEAKYEFSKFARFADYCFGIDPLMIDDQNLEMFPRDRASLKEV
                     ENRMRQLKEAYGFKAIFHTLRSSDEQDKNVYQAYALGERFEESVQLKTAVYQRVGSGD
                     AFISGVLYQLLHHSYLKTTIDFAVASATLKCTLPGDHLSTSETSIEKLLANAQDIIR"
     gene            complement(11528..12169)
                     /locus_tag="VVO18_000882"
     CDS             complement(11528..12169)
                     /locus_tag="VVO18_000882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RpiB/LacA/LacB family sugar-phosphate isomerase"
                     /protein_id="HEU5586061.1"
                     /translation="MKIALINENSQASKNHIIYDSLKEATDKKGYQLFNYGMRGEEGE
                     NPLTYVQNGLMAAILLNTKAVDFVVTGCGTGVGAMLALNSFPGVVCGLAVDPTDAYLY
                     SQINGGNALSIPYAKGFGWGAELTLKLMFERLFAEEMGGGYPRERVIPEQRNARILNE
                     VKQITYNDLMTILKTIDQDFLKDTISGKYFQEYFFENCQDDEVAAYLKEVLAK"
     gene            complement(12188..13003)
                     /locus_tag="VVO18_000883"
     CDS             complement(12188..13003)
                     /locus_tag="VVO18_000883"
                     /EC_number="1.1.1.69"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000185867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gluconate 5-dehydrogenase"
                     /protein_id="HEU5586062.1"
                     /translation="MTNTSFSIEQFSLKGKIALITGASYGIGFAIAKSYAEAGATIVF
                     NDINQDLVNKGIEAYREVGIEAHGYVCDVTDEDGIQAMVKQIEQEVGVIDILVNNAGI
                     IRRVPMCEMSAADFRKVIDIDLNAPFIVSKAVIPSMIKKGHGKIINICSMMSELGRET
                     VSAYAAAKGGLKMLTRNIASEYGGANIQCNGIGPGYIATPQTAPLRELQEDGSRHPFD
                     QFIIAKTPAARWGNPEDLMGPAVFLASDASDFVNGHILYVDGGILAYIGKQPE"
     gene            13275..13709
                     /locus_tag="VVO18_000884"
     CDS             13275..13709
                     /locus_tag="VVO18_000884"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5586063.1"
                     /translation="MKIVLVGHGHFATGIYSSLQLIAGNQENVEAIDFVEGMSADELK
                     QKILLAISNEEEVLILSDLLGGSPFKVSSTIMGENPAKTMNVLSGLNLAMLMEAVFAR
                     MAHSFDEVVNKSVVAAQGGVVNGKELFSTDAEEEEEDFESGI"
     gene            13721..14911
                     /locus_tag="VVO18_000885"
     CDS             13721..14911
                     /locus_tag="VVO18_000885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003074342.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="HEU5586064.1"
                     /translation="MIKKVTIEEIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDY
                     FKENFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYKYSQQDEFKNIAHKNVLSFLDR
                     VNKRVELAHHDLGFLYTPSCMAEYKINGDGEAREAALKAADKLIERYQEKGGFIQAWG
                     DLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHT
                     FYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNY
                     FLNRLPKDHVSYWDLIFNDGSAQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAM
                     HAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDW
                     NLYW"
     gene            14922..15413
                     /locus_tag="VVO18_000886"
     CDS             14922..15413
                     /locus_tag="VVO18_000886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000178618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system
                     mannose/fructose/N-acetylgalactosamine-transporter subunit
                     IIB"
                     /protein_id="HEU5586065.1"
                     /translation="MTTPNIIMTRIDERLIHGQGQLWVKYLGCNTVIVANDEVSTDKM
                     QQTLMKTVVPDSVAMRFFPLQKVIDIIHKANPAQTIFIVVKDVKDALTLVEGGVPIKE
                     INIGNIHNAPGKEQVTRSIFLGEEDKAALKELSQTHQVTFNTKTTPTGNDGAVEVNIM
                     DYI"
     gene            15428..16207
                     /locus_tag="VVO18_000887"
     CDS             15428..16207
                     /locus_tag="VVO18_000887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026606.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS
                     mannose/fructose/sorbose/N-acetylgalactosamine transporter
                     subunit IIC"
                     /protein_id="HEU5586066.1"
                     /translation="MSINVFQAILIGLWTAFCFSGMLLGIYTNRCIVLSFGVGIILGD
                     LPTALAMGAIGELAYMGFGVGAGGTVPPNPIGPGIFGTLMAITSAGKVSPEAALALST
                     PIAVAIQFLQTFAYTVRAGAPETAMKHLKNHNLKKFKFTLNATIWLFAFIGFTLGCLG
                     ALSMDTLLKLVDYIPPVLLTGLTVAGKMLPAIGFAMILSVMAKKELIPFVLLGYVCAA
                     YLNIPTIGIAIVGTIFALIEFYNKPKTANHVVEEEAHDDWI"
     gene            16194..17012
                     /locus_tag="VVO18_000888"
     CDS             16194..17012
                     /locus_tag="VVO18_000888"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000148012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS mannose/fructose/sorbose transporter family
                     subunit IID"
                     /protein_id="HEU5586067.1"
                     /translation="MTGSNKLTKRDYLKTSLRAFFCQNGFNYSNYQGLGYANVMYPAL
                     KKHYGEDQEGFYQALEENCEFYNTNPHFLPFITSLHLVMLENGRPAKETRSIKMALMG
                     PLAGIGDSLSQFCLAPLFSTIAASFAQEGLVVGPILFFLAMNTILTAIKLSTGLYGYK
                     LGTTVIDKLSEQMATISRIANIIGVTVIAGLAATSVKIMVPITFAAGEVKADAKQSIV
                     SIQGMLDKVAPALLPALFTLLVYYLIKEKKWTTYKLVILTVIIGIIGSWLKILA"
     gene            17012..17305
                     /gene="yajC"
                     /locus_tag="VVO18_000889"
     CDS             17012..17305
                     /gene="yajC"
                     /locus_tag="VVO18_000889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000381741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit YajC"
                     /protein_id="HEU5586068.1"
                     /translation="MDTTLFYGIVIVLAVSPLLLSSFHSIRQQKLLRKQMEQRKEYLA
                     SLTSGDEVLLLSGIHGKIISIKDDLVSLQIAKGVVIYVEKESVMGKTKELLFK"
     gene            17327..19228
                     /locus_tag="VVO18_000890"
     CDS             17327..19228
                     /locus_tag="VVO18_000890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000657070.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alginate lyase family protein"
                     /protein_id="HEU5586069.1"
                     /translation="MKEERRQFFERIDGDQYRDYILSHCSKDYEKVKSSLERLMDNRF
                     MFDSPWDMEPCSKIHQIQPMVWDQVFEDDPEWAYMLNRQEYLLQFMIGYLVEGDKGYI
                     QKCKFFLFDWIDQVREFRPQSLMTRTLDTGIRSFTWLKLLLLLLKFDLLEEEELENIL
                     VSLEKQIDFMKSHYRAKYTLSNWGILQTIPILATYHFFSDKMDLEEAYHFASKELKQQ
                     IETQILEDGSQFEQSILYHVEVYKALLDLCLLLPDLQDSFQELLEKMATYIQMMTGLD
                     GRTLAFGDSDSTETTEILSLSAMVLNKEDLLNGLDVKVDLLSLLFLGREKVKRLQEFE
                     KRAWQPKFRSFEDSGHVCIKDEHRYLFFKNGPLGSAHSHSDENSFCLQYQGQPIFIDA
                     GRYSYREVDERYLLKSAWSHSTCIVDGKAPERIVGSWEYEYYPHSLFCHHKEREGVHY
                     IEGAYLSAEPDLPYLHRRKILMLAEDVWLLVDDIRCQGQHEVLTQFILDKDVTYQDGK
                     INQLKLWSEVDFDLEATIISPKYNELEKSSKLTKHQFFENQMLDYTIIAHESFEIIRH
                     SVYQTDGHQVENALAFEVKNDETDKLILLLSEDICVGEKLCLVDGTKMRGKCLVYDKI
                     NERMIRLQC"
     gene            19288..20289
                     /locus_tag="VVO18_000891"
     CDS             19288..20289
                     /locus_tag="VVO18_000891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000412458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5586070.1"
                     /translation="MEKKLTIKDIAEMAQTSKTTVSFYLNGKYEKMSQETREKIEKVI
                     HETNYKPSIVARSLNSKRTKLIGVLIGDITNSFSTQIVKGIEDIASQNGYQVMIGNSN
                     YSQESEDRYIESMLLLGVDGFIIQPTSNFRKYSRIIDEKKKKMVFFDSRLYEHRTSWV
                     KTNNYDAVYDMTQSCIEKGYEHFLLITADTSRLSTRIERASGFVDALTDANMRHARLT
                     IEDKHTNLEQIKEFLQKEINPDEKTLVFVPNCWALPPVFTVIKELNYNLPQVGLIGFD
                     NTEWTCFSSPSVSTLVQPAFEEGQQATKILIDQIEGLNQEERQQVLDCSVSWKESTF"
     gene            complement(20560..21138)
                     /locus_tag="VVO18_000892"
     CDS             complement(20560..21138)
                     /locus_tag="VVO18_000892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3278 domain-containing protein"
                     /protein_id="HEU5586071.1"
                     /translation="MNKEDLTTRLLRNLFHIQGPFDECRQEIIYKACARSMVQIVYSS
                     FFLFLFYLLFGRFIEAVRYAMPYVYSGLIFFITLKTQRAVKELHLEKDDKSEIILKTY
                     SKAQIKFRSWVVFIGIQIGLFTLLIFHKVFVQQMSFSDFGKLLMQFDKSGPFLMYGLI
                     IGSIFGTLTYGFLSLQEEKTPKNTKQKEKSKQ"
     gene            complement(21165..21491)
                     /locus_tag="VVO18_000893"
     CDS             complement(21165..21491)
                     /locus_tag="VVO18_000893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586072.1"
                     /translation="MKSLLTLLTYHLLFSSLLIFIIISGNLPIDETFLVLVFILALNK
                     GLTYLKIDSPKTRTLNLALYFMILSFPQLMLISSDWKYYLLLTIASLSSITYLYYLYQ
                     FVKESQ"
     gene            complement(21502..22044)
                     /locus_tag="VVO18_000894"
     CDS             complement(21502..22044)
                     /locus_tag="VVO18_000894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712356.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3278 domain-containing protein"
                     /protein_id="HEU5586073.1"
                     /translation="MKKETFTEKLIKRIYGISGPLDEHKRREADRIGNQVFIILFYLM
                     IFGNLIPLLLAYKYPQEVALIYPPLILVIALIAAGYVTYKMKKTGITAIDPDMLSEKE
                     SKQLYYPGLKAGLFFGLWMFFITPLLSILIGEGQDYFHSLLTIRNGVSSILGSIFFGA
                     SIQFLISRRIAKAKEDQDED"
     gene            complement(22060..22254)
                     /locus_tag="VVO18_000895"
     CDS             complement(22060..22254)
                     /locus_tag="VVO18_000895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001082472.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5586074.1"
                     /translation="MNRVKEFRKELGISQLELAKDIGVSRQTINMIENDKYNPTLELC
                     LNLARSLQTDLNSLFWEDNF"
     gene            22420..23370
                     /gene="rsmH"
                     /locus_tag="VVO18_000896"
     CDS             22420..23370
                     /gene="rsmH"
                     /locus_tag="VVO18_000896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(1402)-N(4))-methyltransferase
                     RsmH"
                     /protein_id="HEU5586075.1"
                     /translation="MTKEFHHVTVLLHETIDMLDVKPDGIYVDATLGGAGHSEYLLSK
                     LSEKGHLYAFDQDQNAIDNAQKRLAPYIEKGMVTFIKDNFRHLQARLREAGVQEIDGI
                     CYDLGVSSPQLDQRERGFSYKKDAPLDMRMNQDASLTAYEVVNHYDYHDLVRIFFKYG
                     EDKFSKQIARKIEQAREVKPIETTTELAEIIKSAKPAKELKKKGHPAKQIFQAIRIEV
                     NDELGAADESIQQAMDMLALDGRISVITFHSLEDRLTKQLFKEASTVEVPKGLPFIPD
                     DLKPKMELVARKPILPSAEELEANNRSHSAKLRVARKIHK"
     gene            23383..23700
                     /gene="ftsL"
                     /locus_tag="VVO18_000897"
     CDS             23383..23700
                     /gene="ftsL"
                     /locus_tag="VVO18_000897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840841.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsL"
                     /protein_id="HEU5586076.1"
                     /translation="MAERMEKTGQILQMQLKRFSRVEKAFYFSIAVTTLIVAISIIFM
                     QTKLLQVQNDLTKINAQIEEKKTELDDAKQEVNELLRAERLKEIANSHDLQLNNENIR
                     IAE"
     gene            23704..25956
                     /locus_tag="VVO18_000898"
     CDS             23704..25956
                     /locus_tag="VVO18_000898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PASTA domain-containing protein"
                     /protein_id="HEU5586077.1"
                     /translation="MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAVFLVNF
                     AVIIGSGSKFGTDLVKEAKKVHQITRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDK
                     KYKSATGKILYVEDAQFNKVAEVFHKYLDMDEAYVKEQLSQPNLTQVSFGAKGNGITY
                     ANMMAIKKELETAEVKGIDFTTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSG
                     MESSLNSILAGKDGIITYEKDRLGNIVPGTEQVSQQTVDGKDVYTTLSSPLQSFMETQ
                     MDAFLEKVKGKYMTATLVSAKTGEILATTQRPTFNADTKEGITEDFVWRDILYQSNYE
                     PGSAMKVMTLASSIDNNTFPSGEYFNSSEFKIADATTRDWDVNDGLTTGGMMTFLQGF
                     AHSSNVGMSLLEQKMGDATWLDYLKRFKFGVPTRFGLTDEYAGQLPADNIVSIAQSSF
                     GQGISVTQTQMLRAFTAIANDGVMLEPKFISAIYDTNNQSVRKSQKEIVGNPVSKEAA
                     STTRNHMILVGTDPLYGTMYNHYTGKPIITVPGQNVAVKSGTAQIADEKNGGYLVGST
                     NYIFSVVTMNPAENPDFILYVTVQQPEHYSGIQLGEFATPILERASAMKESLNLQSPA
                     KNLDKVTTESSYAMPSIKDISPGELAEALRRNIVQPIVVGTGTKIKETSVEEGTNLAP
                     NQQVLLLSDKVEEIPDMYGWKKETAETFAKWLDIELEFEGSGSVVQKQDVRTNTAIKN
                     IKKIKLTLGD"
     gene            25958..26938
                     /locus_tag="VVO18_000899"
     CDS             25958..26938
                     /locus_tag="VVO18_000899"
                     /EC_number="2.7.8.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000470804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-N-acetylmuramoyl-pentapeptide-
                     transferase"
                     /protein_id="HEU5586078.1"
                     /translation="MFISISAGIVTFLLTLVGIPAFIQFYRKAQITGQQMHEDVKQHQ
                     AKAGTPTMGGLVFLIAAVVVSFLVALFSKQLTNNVGMILFILVLYGLVGFLDDFLKVF
                     RKINEGLNPKQKLALQLLGGVIFYLFYERGGDMLSVFGYQVHLGIFYIIFALFWLVGF
                     SNAVNLTDGIDGLASISVVISLSAYGVIAYVQGQMDILLVIFAMIGGLLGFFVFNHKP
                     AKVFMGDVGSLALGGMLAAISMALHQEWTLLIIGIVYVFETTSVMMQVSYFKLTGGKR
                     IFRMTPVHHHFELGGLSGKGNPWSEWKVDFFFWGVGLLASLLTFAILYLM"
     gene            27502..29607
                     /locus_tag="VVO18_000900"
     CDS             27502..29607
                     /locus_tag="VVO18_000900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001063457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU5586079.1"
                     /translation="MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEF
                     AHYRATGQLPGNAETDVQMPQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEI
                     QETSEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIISIDISGL
                     EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQ
                     HHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREI
                     ETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTG
                     IPVSQMGASDIERLKDMAHRLQDKVIGQDKAVEVVARAIRRNRAGFDEGNRPIGNFLF
                     VGSTGVGKTELAKQLALDMFGTQDAIIRLDMSEYSDRTAVSKLIGTTAGYVGYDDNSN
                     TLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNTVIIATS
                     NAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLA
                     EVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLD
                     AKHLEADMKDGVLVIREKA"
     gene            complement(29902..30384)
                     /locus_tag="VVO18_000901"
     CDS             complement(29902..30384)
                     /locus_tag="VVO18_000901"
                     /EC_number="4.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893508.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteine lyase"
                     /protein_id="HEU5586080.1"
                     /translation="MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLV
                     QPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAV
                     IKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
                     "
     gene            complement(30479..31963)
                     /locus_tag="VVO18_000902"
     CDS             complement(30479..31963)
                     /locus_tag="VVO18_000902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008535024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1846 domain-containing protein"
                     /protein_id="HEU5586081.1"
                     /translation="MKKQAFSSEQYLNLQRDHILERINQFDGKLYLEFGGKMLEDFHA
                     ARVLPGYEPDNKIKLLQELKEQVEVVIAINASNIEHSKARGDLGISYDQEVLRLIDKF
                     NELGIFVGSVVITQYAGQPAADAFRNQLEKNGIDSYLHYPIKGYPTDMDHIISPEGMG
                     KNDYIKTSRNLIVVTAPGPGSGKLATCMSNMYHDQINVIKSGYAKFETFPVWNLPLHH
                     PVNLAYEAATADLDDVNMIDPFHLQTYGETTVNYNRDIEIFPVLKRMLERILGKSPYA
                     SPTDMGVNMVGFAITDDEAAVEASKQEIIRRYYQTVLDFKAEKVGEAAVKKIELLMND
                     LGITPADRKVAVVARQKAEETGGPALAFELPNGEIVTGKNSELFGPTAAALINAIKKS
                     ADIAKEVKLIEPEVVKPIQGLKIDHLGSRNPRLHSNEILIALAITATENPDAARAMEE
                     LGNLKGSEAHSTIILTDEDKNVLRKLGINVTFDPYYQYDRLYRK"
     gene            32116..33723
                     /locus_tag="VVO18_000903"
     CDS             32116..33723
                     /locus_tag="VVO18_000903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glucosidase"
                     /protein_id="HEU5586082.1"
                     /translation="MQEKWWHNAVVYQVYPKSFMDSNEDGIGDLPGITSKLDYLAKLG
                     ITAIWLSPVYDSPMDDNGYDIADYQAIAAIFGTMEDMDQLIAEAKKRDIRIIMDLVVN
                     HTSDEHAWFVEACENPNSPERDYYIWRDEPNDLDSIFSGSAWEYDEKSGQYYLHFFSK
                     KQPDLNWENEKLRQKIYEMMNFWIDKGIGGFRMDVIDMIGKIPDEKVVNNGPMLHPYL
                     KEMNQATFGDKDLLTVGETWGATPEIAKLYSDPKGQELSMVFQFEHIGLQYQEGQPKW
                     HYQKELNIAKLKEIFNKWQTELGVEDGWNSLFWNNHDLPRIVSIWGNDQEYREKSAKA
                     FAILLHLMRGTPYIYQGEEIGMTNYPFETLDQVEDIESLNYAREALEKGVPIEEIMDS
                     IRVIGRDNARTPMQWDESKNAGFSTGQPWLAVNPNYEMINVQEALANPDSIFYTYQKL
                     VQIRKENSWLIRADFELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSV
                     LIENTLAQEVFEKQILVPWDAFCVELL"
     gene            33888..34055
                     /locus_tag="VVO18_000904"
     CDS             33888..34055
                     /locus_tag="VVO18_000904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001022221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-ribosylhomocysteinase"
                     /protein_id="HEU5586083.1"
                     /translation="MKKRILSAGLTFTSALLLAACGQSGSDTKTYSSTFSGNPTTFNY
                     LLDYYADNIVN"
     gene            complement(34048..34471)
                     /locus_tag="VVO18_000905"
                     /pseudo
     CDS             complement(34048..34471)
                     /locus_tag="VVO18_000905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT        10591 a         6073 c         7604 g        10203 t
ORIGIN      
        1 ttgtccaatt ggaaaagaac tcacttagtt tataatcctg atctagtata atttgtattt
       61 gaaaccagtc tttagaaagt aaaaattatt atgttttatt aaggaggtct atttatggat
      121 caacaaaacg ggttgtttgg ttttcttgaa aaccatgtta tgggaccaat gggcaaactt
      181 gctcagttta aagtagtacg tgctatcacg gctgcaggta tggctgctgt accatttact
      241 attgtaggat caatgttttt ggtattcagt attttgccac aagctttctc attttggcca
      301 attgtggcag atattttctc tgcttcattt gataaattca catcacttta catggttgca
      361 aactatgcga ctatgggttc tctatctctt tatttcgttc tatcacttgc atatgaattg
      421 acaaaaattt atgcagagga agaagaactc aatatgaatc ctcttaatgg tgccttgctt
      481 gccttgatgg cttttgtcat gacagtaccg caaatcattt ttgatggtgg aatgatgaag
      541 actgtgacaa gtctaaaaga aggtgcagta attgcagatg gatgggcaat gggaaatgga
      601 gtcgcacgtt ttgggacaac agggattttt accgcaatca ttatggcaat tgtgactgtt
      661 cttatttatc gtatgtgtgt taaacataat tgggttatta aaatgcctga agctgttcca
      721 gaaggagttt ctcgtggatt taccgctttg gttccgggat ttgttgttgc atttgttgtt
      781 atctttatca acggtcttct tgtagcaatg ggaacggata tttttaaagt cattgcaatt
      841 ccatttggtt ttgtatccaa tctgactaat tcgtggattg gtttaatgat tatttatcta
      901 ttgactcaac tactttggat tgtaggtatc cacggtgcga acattgtttt tgcatttgtt
      961 agtccaattg ctcttgctaa catggctgaa aatgctgctg gcgggcactt cgctgttgca
     1021 ggtgaatttt ctaatatgtt tgtaattgca ggtggttctg gtgcaacttt aggactatgt
     1081 ttatatattg cttttgcctc taaatctgaa cagcttaaag caataggacg agcatctgta
     1141 gttccggcct tatttaatat taatgaacca ttaatttttg gattacctat tatctataat
     1201 ccagccttag ctataccatt tattttagca ccaatggtta ctgctactat ttattacgta
     1261 gcgaattctc taaactttat taagccaatt atcgcacagg ttccatggcc aactccagta
     1321 gggattggag ctttcttagg gacagcagat cttcgagctg tattagttgc tctagtatgt
     1381 gcatttgcag cattcctagt ctatcttcca ttcatccgtg tatatgatca aaaattggtg
     1441 aaagaagagc aaggtatcta ataagtaaaa aagtatactc gatgatagaa tccatatagt
     1501 ttaaataatg agcgttaaca ttagcagtga agaggtcttt ttaagatatt cttctctgct
     1561 ttttcatatt ttttcgctat gtagggtatg aagcaaaata gaaagtagtt cgaatagttg
     1621 ataaacaggg aattgctgtt atttaaaaaa aaacaataaa gtaaagtatg ttatcgtaga
     1681 atacgataca atagtaaaaa agcaaaaaga atgcgtttta tatttgggtt tgaggtttat
     1741 aaaataggat aagcatgctg aaaacttaga tatgacaaac aaaataaaat ttttaaaagc
     1801 tacatagaaa catggtataa tgtatctaaa ggaggtagca tatgtcctta gatatagata
     1861 aagaaaagat gacaatcatg ggaatagctt ttgaaaaccg atccgttttt aagagtgttt
     1921 ggtatgcttt aagtacaaat atgattgaag gatggcgacc tacggttagt gatgttgaaa
     1981 aattacgaga tgaagctctt gctctgggga tgacttaatg aagcgcaact gttatgagtc
     2041 ttatgactat gttgatccgg ataatttata taccgatccg ggttcttcag ttctaagaaa
     2101 taagcaggaa ggaaaaaagc acgcgagctt gaatatcgta tgattgctag taagagtttg
     2161 aaattattta tcaatcctat cttagttaat agtttaaaag tagtttgttt cacaactgca
     2221 taagcttaga aaagttgaaa agtgataact ctttaataaa ctcttggttt gttaaaagat
     2281 attttgtcca ctacattttt tcaattgact attatttgtc atagatataa cagatagaac
     2341 attgcattca gaataatgaa aaacgcatca aaaatggtgc gttctgtttt tatgctacca
     2401 taaaaggagg aaaacaaatt gaaaattttt aagggagagt tttatcgaat ctctgtatta
     2461 acagacaagc tagtaaggtt agaatactct cgaactggaa attttgagga tagaacgaca
     2521 caacttatct ataatagaga ttttggccaa gtttcgttag attatatcga gacatcaaat
     2581 gtactagata ttatgacgga ctattttcat ctgcacttta ataaaggaga atttaacgcc
     2641 gaaaatttat ttatagaatt aaaaggaaat tttgccgtat atggtagtcg ctggtatttt
     2701 ggtgaatcta ttgaaacgtt aaaaggaaca gctcggactc tggataaggc agatggagca
     2761 atctcgttag aagatggaat tattagccga aatggtatag ccttattgga tgattctcaa
     2821 ggatttattt gggatgaaca atctggttat attgagagag aaaatcaaat tgacctgtat
     2881 ttctttgcct atgggcatga ttatagagga gcaatcagag acttttacca tttgactggt
     2941 tcaataccct tgttgccaag atatgcttta ggcaattggt ggagtagata ttggccttat
     3001 acgtcggatg aatacttgga tttaatagac agatttgaaa cagagaaaat tccattatct
     3061 atcggtgtgt tagatatgga ttggcatata actgacattc cagctcgttt tggaagtggc
     3121 tggacaggat atagttggaa tagaaactta ataccaaatc cagaacagtt attgcaacaa
     3181 cttcatgata gaaagttaaa actctcctta aatgtccatc ctgctgatgg gatacgggct
     3241 tatgaagaag cttatcctca aatcgcaaaa cgattggggt taaatgtaga actagaagaa
     3301 cctgctattt ttgatttttt taatccctct tttagggaag cctactttaa agatgttcat
     3361 tatgagctag aaaagcaggg agtagatttt tggtggattg actggcaaca ggggacacaa
     3421 ggcatgctag atccactttg gcttttaaac cattatcact atcaggatag ttgtaaaaat
     3481 gcagaaggtg gtttgatttt atcaagatat gcaggtcctg gtagtcaccg ctaccctgtt
     3541 ggtttttcag gggatactat tattagttgg aattccttaa gatttcaacc ctattttaca
     3601 gcgacagcat ctaatatcgg ttatagttgg tggagtcatg atatcggtgg acatatgttg
     3661 ggggattatg acgaagagct acaaactaga tggctacagt ttggtgtttt tagtccgatt
     3721 actcgattac atagttctag aagtcctttt aatagtaaag aaccttggtt tttttcagaa
     3781 acaacatcta agattatgaa gaaatacctt cgtttgagac atcagatgat tccctatcta
     3841 tataccatga atgtacagac acatgaggaa ggtgccccat taatcagtcc aatctattat
     3901 ttctatccag agaatgatga gagctataat gttccaaacc aatacttttt tggaacagaa
     3961 ctgatggtgg ctcccattgt agaaaagatg gatttgacat tccaatctgc aaaagtagat
     4021 gtatggttcc ctgaaggtga atggtatgac tttttttcag agaaaaaata cacaggtggt
     4081 gtgaagttaa gtgtttatag ggacatctcg actacgcctg tgtttgcaaa aagtggtgca
     4141 atcattccct tggttggttc tgagatagat atgggtgttg atttacctga agttgtagat
     4201 tggtatgtat tcccaggaaa acaacattat tttgaaatgc ttgaagatca aaatggtcaa
     4261 agatataaaa caagattatc aatcgattgg gaaatgggaa tggtagagtt agcattacaa
     4321 ggagattcta gtatcgttcc aagcaataga aaacatagaa ttcattttaa aggaacgaat
     4381 gtgtctataa ttgaattgcc aaataagaat gatacagcta aatttgaatg gaaagataat
     4441 aaaaggacat ctttaaatga cgaagttttt agactactaa agacagcttc tcttccatat
     4501 gaattaaaag atagattgtt aaatcaattc atcaatgcga aaaactctca tgacttaatg
     4561 aatatcttgc atcatcagga taaggaattg agagggcgtt tgttggaaat gatatttact
     4621 agccaaaact aattgatata attagaaagt catttgttta gtgtatatga agattctgta
     4681 tggtattcgt tatcactggt cacattgaaa atgtgaaata agcacctaca acatagactt
     4741 tacaacactt catgtttcat atcatggggt gtttttctat ttaagtcaaa gccaatcaaa
     4801 aaatctcact attcatcagg ttaaaggaaa cctaatcata gtgagattgt gaattatagt
     4861 agagtttgta tcgcctcttc aatttgtttt gggtctgttt ttgaagaaaa gcgttcaaag
     4921 acttgcccat cacgactaat gagaaactta gcgaaattcc attcgattcg ttttcctagt
     4981 gggccagatt tatggtcttt taaccagaca tagagagggt ctgcttcctt accgttgacc
     5041 ttaatcttgg caaaacgtgg gaaggtggtt tgaaaatgta ggctacagaa ggcgttgatt
     5101 tcctctgcgc tgccgggtgc ttgtcccata aactgattgc aagggaaatc caatatttcg
     5161 aagccctgat cttgatagcg ttcatagagt tcttgaagtc cctggtactg gggcattaaa
     5221 ccacatccag tagtagtgtt gacaatcaag agaactttgc cacgatagct atccaaggga
     5281 gttgcttggt tgttttggtt caaaacggaa aaatcataaa gtgaagtcat gagggcctct
     5341 tttctttttc tacattgtaa cagtttttac ttttttcgtc gagtcggatg gaagatattg
     5401 ttgaagaata agccctcaat atgatagaaa ccgtttacaa ataactttaa aaatggtatg
     5461 atttaattaa accggtttac ttagttgcta taaatctcta atttgagatt tagttcctat
     5521 tgattttaca atatgtttat tggagtgtat acatgcaaac aaaaacaaag aagctcattg
     5581 tgagtttgtc ttcacttgtt ttatcaggat ttttattaaa ccattatatg acagttggag
     5641 cggaagaaac gactacgaat accattcagc aaagccagaa ggaagttcag tatcagcaaa
     5701 gggatacaaa aaatttagtt gaaaatggtg attttggtca gacggaggac ggaagcagtc
     5761 cgtggacagg aagcaaagct caggggtggt cagcttgggt agaccagaag aatagttctg
     5821 cagatgcctc aactcgagtc attgaggcta aggatggggc tatcactatc tcaagccctg
     5881 agaaattaag ggtagcggtt caccgtatgg ttcctattga agctaagaaa aagtataaac
     5941 tgcgtttcaa gattaaaaca gataataaag tcgggattgc caaagttcgt atcattgagg
     6001 aaagtggtaa ggacaagcga ttgtggaatt ctgcaacgac gtcaggaaca aaggactggc
     6061 agaccattga agcagactat agcccgactt tagatgttga taaaatcaag ctggagttat
     6121 tctatgaaac aggaactggg actgtttcct ttaaggatat tgagctggta gaggtagcag
     6181 accagccttc tgaggattct caaacagata aacagcttga ggaaaagatt gatttaccaa
     6241 ttggaaaaaa acatgttttt tctcttgcgg actatactta taaggtagaa aatcctgacg
     6301 ttgcttcagt caaaaatgga attttagaac ctcttaagga agggacaacc aatgtcattg
     6361 tcagtaaaga tggcaaggaa gtgaaaaaga ttcctttgaa gattctagcc tctgttaagg
     6421 atgcatacac agaccgtttg gatgactgga atggcatcat cgctgggaat caatactatg
     6481 attctaaaaa tgaacagatg gccaaattaa accaggaatt ggaaggaaag gtagctgata
     6541 gcctatccag tatttcaagt caggcggacc gcatctattt gtgggaaaaa ttttcaaatt
     6601 ataaaacgtc tgcaaatctg actgccactt atcggaaatt ggaggagatg gccaagcaag
     6661 tgaccaatcc ttcttctcgt tattataaag atgaaactgt cgttcgaaca gtcagggatt
     6721 ccatggaatg gatgcataaa catgtctaca atagtgaaaa gagcattgtt gggaactggt
     6781 gggattatga aattggtaca cctcgtgcca tcaacaatac cttgtctctg atgaaagaat
     6841 acttctctga tgaggaaatt aaaaaatata cagatgtaat tgaaaaattt gtaccagatc
     6901 ccgaacattt ccgaaagacg actgataacc catttaaggc tctaggtgga aacttagttg
     6961 atatgggaag agtaaaagta atagctggtt tactgcgtaa agatgatcaa gaaatttctt
     7021 ctaccattcg ctcgattgag caagtgttca agttggtaga ccaaggtgaa ggtttttatc
     7081 aagatggatc ctatatcgac cataccaatg ttgcctatac gggtgcttat gggaatgttt
     7141 tgattgatgg cctgtctcaa ctgttgccag tcattcaaaa gaccaagaat ccaatcgata
     7201 aagataaaat gcaaaccatg taccactgga ttgataaatc gtttgctcct ttgctggtga
     7261 atggagagct gatggatatg agtcgtggac gctcgatcag tcgtgcaaat agcgaggggc
     7321 acgtggccgc agtagaagta ctaagaggga ttcaccgaat agcggatatg tctgaaggag
     7381 aaaccaaaca acgtttgcag agtcttgtga agaccattgt tcaatcggat agttattatg
     7441 atgtctttaa gaatttgaag acttataagg atatcagttt gatgcaatcc ttgttaagtg
     7501 atgcaggagt cgcaagtgtt ccaagaacaa gttacctatc tgcctttaac aagatggata
     7561 aaacagccat gtacaatgca gagaaagggt ttggatttgg cttgtcactc ttttccagtc
     7621 gtaccttgaa ttacgaacat atgaacaagg aaaataaacg tggttggtat acgagtgatg
     7681 ggatgttcta tctttacaat ggcgatttga gtcactatag cgatggctac tggccaacag
     7741 tcaatccata taagatgcct ggtacaacag agacggatgc taagagagcg gatagcgata
     7801 caggtaaagt tttaccgtct gctttcgttg gaacgagcaa actagatgat gccaatgcga
     7861 cagcaaccat ggatttcacc aactggaatc aaacattgac tgctcataag agctggttta
     7921 tgctaaagga taagatcgcc tttttaggaa gcaatatcca aaacacttca acagatactg
     7981 ctgcaactac aattgaccag agaaaactgg aatcaggtaa tccatataaa gtctatgtca
     8041 atgataaaga agcctccctt acagaacaag aaaaggatta tcctgaaacc caaagtgtct
     8101 ttttagaatc gtccgattcg aaaaagaata ttggttactt tttctttaag aagagttcaa
     8161 tcagtatgag taaggctttg caaaagggag cctggaagga tatcaatgaa ggacagtcag
     8221 acaaggaagt tgaaaatgaa tttcttacga ttagtcaggc tcataagcaa aatggagatt
     8281 cttatggcta tatgctcatc cctaacgtgg atcgtgccac cttcaatcaa atgataaaag
     8341 agttagaaag tagcctcatc gacaataacg aaacccttca gtctgtttat gatgccaaac
     8401 aaggagtttg gggcattgtg aaatatgatg attctgtctc tactatttcc aaccaattcc
     8461 aagttttgaa acgtggagtc tatatcattc gaaaagaagg ggatgaatat aagattgcct
     8521 actataatcc tgaaacccag gaatcagctc cagatcagga agtctttaaa aagctagagc
     8581 aagcaactca gccacaagta cagaattcaa aagaaaagga aaaatctgaa gaggaaaaga
     8641 accattcgga tcaaaagaat ctccctcaga caggagaagg tcagtcaatc ttggcaagtc
     8701 tagggttctt gctacttggg gcgttttatc tattccgtag aggaaagaac aactaatttg
     8761 ttcatcatct agatgaatta catgaaactg tggaaaatag aaaaatccga agaaggccaa
     8821 atatcttcgg atttttcttt taaaaaagat aagttgatac ttatcctttt ttacttcatt
     8881 atgtgactat agcgttttga aactagaata ggacgttata actgctaaaa gatttctata
     8941 aattcatttg attttcctaa tcaatttgtt cgtatcctat ttcactccac tatattagtc
     9001 cgtctcgctc cgtgaggtgc gcgtcgaagg ttataccaaa aaaactccaa acgcgataca
     9061 ataaaggtgt tcaatccaat tgtaaagcga aaggagaaaa aatatggcac aaaaggctca
     9121 tagtttatca tacacaaagt ggatgtgttc tatcatattg tgttcacccc taagtataga
     9181 cgaaaagtca tctataatca atatagaagt agtttaggcg aaatatttca tcgcttgtgt
     9241 agttataaag gtgttgaaat gatcgagggt cacttaatgc cagaccatgt acacatgtta
     9301 gtcagtattc cgtcgaggct aagtgtgggg tatttaaaag gcaaaagtgc actcatgatg
     9361 tttgacaaac acgccaatct caagtataag tttgggaatc ggcatttctg ggcggaaggt
     9421 tattatgtga gcacagtagg gcttaataaa gccacaatta agaaatatag tcaagattaa
     9481 agaaattatc cagtggatga tttcttcaca agtatgaaaa tttgagaacg agtaaagcat
     9541 gatatatagt aaaatgaaat aagaacagaa caaatcgatc aggacagtca aatcgatttt
     9601 taacaatgtt ttagaagtag aggtgtacta ttccagtttc aatctactat agcactagat
     9661 aaattgagtg taaaagaata tgaagatccg ttttctgatg gcggatttag aacaaggtaa
     9721 aagcccgttg tgacgggcat tagtcaagta atatagcacg acctgaacga agttcagcga
     9781 gcgtttttag acgccgctgg agagaaacgg cttatagctc tgggataaac caccccttag
     9841 acgggtggtt atgattttat ctgagtgtaa catactgttg ggcaatctcg ctgatgcggt
     9901 caaagtcgcc ttgggaagcg agtttattga gttcgccacc aattccaacg gcgtctgcac
     9961 cagcagcgaa ccattgagga atgttgttta ggccgactcc tccggttacc attacggaaa
    10021 cttgtgggat cggtgccttg actgcagaga tatatgctgg actgagagca ctacctggga
    10081 agagtttaat gatttcacta ccggcttcaa gtgcagtcgt tatctctgtg agagtaatac
    10141 agcctggaat gtacggtgtg ctgtagagat tgcacatttt tgcagtttca gcatggaaag
    10201 atggagaaac aacgtaattt gctccggcta gaatagcatc tctagcagtt acggcatcaa
    10261 tcacagtacc tgcaccgata caaacacttt gatcgtcctg atacaagtct acaagttgct
    10321 tgatgatttg ccctgcatac tgattggtat aggcgatttc aatagctttg ataccgccct
    10381 tgatacaagc aatcgaggct tgcagtcctt cttcctttgt atttcctcga ataacagcga
    10441 caattttttg tttttttagt tcaataatcg tatctgattt ggtcatgtaa ttctcctaac
    10501 gaatgatatc ttgtgcattt gccagtaatt tttcaatact agtttcggaa gtggagagat
    10561 ggtctcctgg aagagtacat ttgagagttg cgctcgcaac tgcaaagtca atggtagttt
    10621 ttaagtagga atgatggagt agttgataaa ggacaccaga tataaaggca tccccgctac
    10681 caactcgttg atagactgca gtttttagtt ggacagactc ttcaaatcgt tctcccagag
    10741 cataggcctg atagacattt ttgtcttgtt catcactaga gcggagggta tggaaaatgg
    10801 ccttgaaacc ataggcttct tttaattgtc gcatgcgatt ttccacctct tttaggctgg
    10861 ctctgtctct tgggaacatc tctagatttt ggtcatcaat catgagagga tcaataccaa
    10921 agcaatagtc agcgaaacgt gcaaacttag aaaattcata cttggcttct aggactgaaa
    10981 tcatctttgt tctcagattg aggtccattg aaacgataat ccctcggcgc ttggcttctt
    11041 ccaagagtag gagaaggagc gtacgaacct cttgaccgat agctacagtg attccactaa
    11101 aatgaaaatg gctaatcccc tgaaagagag aacccatatc tagcatgttt ggccgaatct
    11161 ggctgatact cgtatgctta cgatcgtaga aaacttcact ttgacgacaa ccaaagccgt
    11221 tctccaaaaa gtagaggccg attcgatcgc caagccgaca gattgaactg gtatcgattt
    11281 ggtgctgttt caagaatgtg agaaaacgat ctccaatctc gttggcaggg agtgcggtaa
    11341 agactttcgt tgagataccc agggcttgca aattacaagc gatgttaatt tctgatccgc
    11401 caaaataagt cgaactggca acatgatcgc cgatactggt ggcatctaat ggtgagattc
    11461 gaattaatgg ttcgccaaac agtaatattt tcgtcatcca ttagttcctt tctggtttag
    11521 aatagcttta cttggctaat acttctttca aataagcagc gacttcatca tcttggcagt
    11581 tttcaaagaa gtattcttgg aagtatttgc cagagatggt gtctttgagg aagtcttggt
    11641 cgattgtttt aaggatggtc atcaaatcat tgtaggtgat ttgtttcacc tcgtttaaga
    11701 tacgagcgtt gcgttgttca gggattacac gttctcttgg gtagccaccg cccatttctt
    11761 cagcaaataa gcgttcaaac atcaatttga gggtcagttc tgccccccag ccaaatcctt
    11821 tggcataagg gatagacaag gcgttaccac cattgatttg agaataaagg taagcgtcag
    11881 ttgggtccac tgctagacca cagacaacac cagggaagct gtttaaagca agcatagctc
    11941 ctacacccgt accacagccg gtaacaacaa agtcgactgc ttttgtattt aaaaggatgg
    12001 cagccattag gccgttttgt acgtatgtta atgggttttc accttcttct ccacgcatac
    12061 catagttaaa taattggtag ccttttttat ctgttgcttc ttttagacta tcgtaaataa
    12121 tgtgattctt actagcttga ctattttcat tgattaatgc gattttcata agatcctctt
    12181 tctattttta ctcaggttgt tttccgatgt aggctaagat accgccatct acatatagga
    12241 tgtggccatt gacaaagtcg ctggcatcac tagcgagaaa gacagcaggg cccattaaat
    12301 cttcaggatt tccccaacgt gcagcaggtg tttttgcaat gatgaactgg tcaaatgggt
    12361 ggcgagaacc atcttcttgc aactcacgaa gaggtgctgt ttgaggagtg gcaatataac
    12421 ccggtccgat tccgttacat tggatattgg ctccaccgta ttcagacgca atgttgcggg
    12481 tcaacatttt caagccgcct ttagcggcag cataagcgct aaccgtttca cgtcccagtt
    12541 cgctcatcat cgagcaaata ttgataatct ttccatgccc tttctttatc atagaaggaa
    12601 tgactgcttt tgaaacgata aatggtgcgt ttaagtcaat atcgatgacc ttacggaaat
    12661 cagcggcgct catttcgcac attggaacgc ggcggataat accagcgtta ttaacaagga
    12721 tgtcaatgac accaacctct tgttcgattt gcttgaccat ggcttggata ccgtcctcgt
    12781 ctgtcacgtc acagacatac ccatgggctt cgatgccaac ttcacgataa gcttcaatcc
    12841 ctttattgac caggtcttga ttgatatcgt taaagacaat agtagcgccg gcctcagcgt
    12901 aggatttggc aatagcaaat ccaattccat aagaagcgcc ggtgatgaga gcaatttttc
    12961 cttttaaaga aaactgctca attgagaatg atgtatttgt catttgatac ttcctttcaa
    13021 atttgttaag acttctctat aaccaaatta tattctagta aaccggtttt gtcaataatt
    13081 aaatattttt atttctgaaa atctttgttt tcctaaaaaa acggaagatt ttgaagtttc
    13141 tgtctattgc aatggttaaa taagcaatga aagcgctaat atttttttga aaaaactatt
    13201 gacaagataa aaataaaggt ctacaatgta aaatatagag taaaccggta aactcaaaaa
    13261 agaaaggaga aaagatgaaa attgtacttg tagggcatgg acattttgcc acagggattt
    13321 atagttcttt acaattgatt gcaggcaatc aagaaaatgt ggaggcgatt gactttgtgg
    13381 aaggaatgtc agcagatgaa ctcaagcaaa aaatcttact tgcaatttca aatgaagaag
    13441 aagttttaat cctaagtgat ctcttgggag gatcgccatt caaggtttct tctaccataa
    13501 tgggagaaaa tccagccaaa acaatgaatg ttctctcggg tttgaactta gccatgttaa
    13561 tggaagcagt ctttgctaga atggctcata gctttgatga ggttgttaat aaatcagtag
    13621 tggcggccca gggcggagtc gtaaatggta aagaattgtt ttcaacggat gcagaggaag
    13681 aggaagaaga tttcgaatcg ggtatttaaa gggtaaaaga atgataaaaa aggttacgat
    13741 tgaagaaata aaatcgcctg agcgcttctt agaagtacca cttctgacga aagaagaagt
    13801 cggccaggca atcgataagg ttattcggca gttagaactc aaccttgact atttcaagga
    13861 aaatttcccg acgccagcta cctttgataa tgtctatcca atcatggata atacggaatg
    13921 gaccaatggt ttctggacag gagaactgtg gttggcttat aaatacagtc aacaggatga
    13981 atttaaaaac atcgctcata aaaatgttct ttctttcctg gatcgtgtca ataagagagt
    14041 agaattggct caccatgatc tcggcttctt gtacacaccg tcttgtatgg ctgaatataa
    14101 gataaatgga gatggagagg ccagagaggc agccttgaaa gctgcagata agttgattga
    14161 acgctatcaa gaaaaaggtg gttttattca agcttgggga gacttgggca agaaagagca
    14221 ttaccgtttg attatcgact gcttgctcaa tatccaactc ttattctttg cttatcaaga
    14281 aacaggcgat caaaaatact acgatattgc agaaagtcat ttctatgctt cagctaataa
    14341 tgtaatccgt gatgacgctt cgtccttcca caccttctat tttgatcctg agacaggtca
    14401 accctttaaa ggtgtaacga gacaagggta tagtgatgat tcatgctggg cacgtggtca
    14461 atcatgggga gtctatggta ttcctttgac ttatcgtcac ttaaaagacg agtcctgctt
    14521 tgacttgttt aagggtgtga ccaattattt cttgaatcgt ctgccaaaag atcatgtgtc
    14581 ctattgggat ttgattttta atgatggtag tgctcaatca cgagattctt cagcaacagc
    14641 tatcgccgtc tgtgggattc atgaaatgct aaaacatctc ccagaggtgg atgctgacaa
    14701 agatatttat aaacatgcta tgcatgccat gcttcgttct ttgatcgaac attatgcaaa
    14761 tgatcaattt acccctggtg ggacaagtct cctccacggt gtgtactcat ggcattcagg
    14821 taaaggagtg gatgaaggca atatctgggg tgactactat tacctagaag cccttatccg
    14881 tttctacaaa gactggaacc tatattggta ggaggagaaa tatgacaacg ccaaatatta
    14941 ttatgacccg tatcgatgaa cggttgattc atgggcaagg acaactttgg gtaaaatacc
    15001 taggttgtaa tacggtcatt gttgccaatg acgaagtaag cacggacaag atgcaacaaa
    15061 ctctgatgaa aacagttgtg ccagactcag ttgccatgcg tttcttccct ttgcaaaagg
    15121 tgattgatat cattcacaag gctaatcctg ctcaaacgat ctttatcgtt gtaaaggatg
    15181 taaaggacgc tttaaccttg gtagaaggtg gtgtccctat caaagaaatc aatattggga
    15241 acattcacaa tgcccctggt aaagagcaag tgacacgctc catcttcctg ggtgaagagg
    15301 acaaggcagc cctcaaggaa ttaagccaaa ctcatcaagt aacatttaat acgaaaacaa
    15361 ctccaacagg aaatgatgga gctgttgaag tcaacattat ggactatatt taaaagagga
    15421 gatcgttatg tcgattaatg tatttcaagc gattttaatt ggattatgga cagctttctg
    15481 ttttagtgga atgctgttag gaatttacac caatagatgt attgttctgt catttggtgt
    15541 cggaattatt ctaggtgatt tgcctactgc tcttgcaatg ggagctattg gtgaattggc
    15601 ttatatggga ttcggtgttg gtgctggagg tactgttcca ccaaatccaa tcggacctgg
    15661 tatctttggt accttgatgg ctatcactag tgctggtaaa gtcagtccag aagcggctct
    15721 tgccctctct actccgattg ctgtagcgat tcaattctta caaactttcg cctacactgt
    15781 acgtgctggt gcgcctgaaa cggcgatgaa gcacttgaaa aaccataatt tgaagaaatt
    15841 caagttcact ctaaatgcaa caatttggtt gtttgccttt attggattta ccttgggttg
    15901 cttgggtgcc ctttcaatgg ataccttgtt gaaactcgta gactacattc caccagtatt
    15961 gcttacaggt ttgacagttg ctggtaaaat gctcccagct atcggttttg caatgatctt
    16021 gtcagtgatg gctaagaaag agttgattcc gtttgtcttg ttgggatatg tttgtgcggc
    16081 ttatctaaac atcccaacaa ttggtattgc aattgtaggt actatctttg ctttgattga
    16141 attttataac aagccaaaaa cagcgaatca tgtggtagag gaggaagcac acgatgactg
    16201 gatctaacaa attaacaaaa cgtgattatc ttaaaacgtc tttgcgggca ttcttttgtc
    16261 aaaatggatt taactatagt aactatcagg gattaggata tgctaatgtg atgtatcctg
    16321 ctttgaaaaa acactatgga gaggatcagg aaggtttcta ccaagccttg gaagaaaact
    16381 gtgaattcta taataccaac ccacacttcc tgccttttat taccagtttg caccttgtaa
    16441 tgttggaaaa tggccgtccg gcaaaagaga cacgtagcat caagatggcc ttgatggggc
    16501 cattggcagg tattggggat tctctctcac aattttgttt agctccattg ttctcaacca
    16561 tcgcagcttc ttttgctcaa gaaggcctgg ttgtcggtcc aatcttgttc ttcctagcga
    16621 tgaatacgat tttgacagcg attaaattgt caactggtct ctatggatac aaactaggaa
    16681 caactgtgat tgataagctg agcgaacaga tggcaacgat ttctcgtatt gctaatatta
    16741 tcggtgtaac cgtaattgct ggtttggcag cgacatctgt gaagattatg gtgccaatca
    16801 cctttgctgc aggggaagtt aaagcagacg ctaaacaaag tatcgtaagt attcagggaa
    16861 tgcttgataa ggttgctcca gctcttctac cagccctatt tacactttta gtttactact
    16921 tgatcaaaga aaagaaatgg acaacatata aactcgttat tttaacagtt atcatcggaa
    16981 ttatcggaag ctggcttaag attctagctt aatggataca acattgtttt atggaatagt
    17041 gattgtcttg gcagtgagcc cccttttact gtcaagcttt cattctattc gtcagcaaaa
    17101 gttgcttcgc aaacagatgg agcaacgaaa agagtattta gcttctttaa catctggtga
    17161 tgaagtgttg ttattgtctg gaattcatgg aaaaatcatt tctatcaaag atgacttggt
    17221 ctccttgcag attgcaaaag gtgtggtcat ctatgtagaa aaggaaagtg taatgggaaa
    17281 gacaaaagaa ctgcttttta agtagttctt tttctggtaa tagataatga aagaagaaag
    17341 aagacaattt tttgaaagaa ttgatgggga ccaatatcgt gattatatct tgtcccactg
    17401 ttcaaaagac tatgagaaag tcaagagttc ccttgagcgc ttgatggaca atcgttttat
    17461 gtttgatagt ccttgggata tggaaccttg ttcaaaaatc catcaaatcc agccgatggt
    17521 atgggatcaa gtatttgaag atgatccaga atgggcttat atgctcaatc gacaagaata
    17581 tctcttgcag tttatgatag ggtatctggt agaaggagat aagggctata ttcaaaagtg
    17641 caagttcttt ctatttgact ggattgatca ggtgagagaa tttcgtcctc aatctttgat
    17701 gactagaacc ttggatacgg gtattcgttc ctttacttgg ttgaaactac tcttgctcct
    17761 cttgaaattt gacttgctag aggaggaaga actagagaac attttggtca gtctagaaaa
    17821 gcagattgac tttatgaaaa gccattatcg cgccaagtac acccttagta actgggggat
    17881 tttacaaacg attccgatac ttgcaaccta tcatttcttt tcagataaga tggacctaga
    17941 agaagcttac cattttgctt caaaggagtt gaaacagcag atcgagacgc agattttaga
    18001 agatggaagc cagtttgaac agtcgattct ctatcatgta gaggtttata aagccttgct
    18061 ggacttgtgt ctcttgcttc cggacttgca agatagcttt caagagctgc tggaaaagat
    18121 ggcgacttac attcaaatga tgacaggtct agatggacgg accttggctt ttggtgatag
    18181 cgattctaca gaaacgacag agattttgag cctgtctgct atggttttga acaaggaaga
    18241 ccttcttaac ggtctggatg ttaaagtcga tttacttagc ctcttgttcc tggggcgaga
    18301 aaaggtcaag cgactgcagg aatttgaaaa gagagcttgg cagcctaagt tcaggagctt
    18361 tgaagattct gggcatgttt gcattaagga tgaacatcgt tatctatttt ttaaaaacgg
    18421 tccgctggga agtgcccata gccatagtga cgagaatagt ttttgcttac agtatcaagg
    18481 ccaaccgatt ttcatagatg ctgggcgtta ttcttatcgg gaggttgatg aacgttatct
    18541 cttaaagagt gcttggagtc attcgacctg tatagtagat gggaaagctc cagaaaggat
    18601 cgtgggatcc tgggaatatg aatactatcc tcactccctg ttctgccacc acaaagaaag
    18661 agagggagtg cattatattg agggggctta tttgtcagca gaacctgatt tgccttatct
    18721 tcacaggaga aaaatcctca tgttggcaga ggatgtatgg ctcttggtag atgatatcag
    18781 gtgtcaaggt cagcatgagg tgttgactca gtttatcctt gacaaggatg tgacctatca
    18841 agatgggaaa atcaatcagt tgaaactatg gagtgaagtt gattttgatt tggaagctac
    18901 gatcatttct cctaaataca acgagcttga aaaaagtagc aaactcacca aacaccaatt
    18961 ctttgagaat cagatgctgg attatacaat cattgcgcat gagagttttg aaatcatccg
    19021 tcattctgtc taccagacag atggtcatca agtagaaaat gctctggctt ttgaagtgaa
    19081 aaatgacgaa acagacaagc tgattctgtt attaagcgag gatatttgtg taggtgaaaa
    19141 attatgcctc gttgacggaa caaaaatgcg tggaaaatgt ctagtatatg ataaaataaa
    19201 tgagagaatg attcgcttgc agtgctagaa atagacgttt tgaatagtga atatgttata
    19261 atgggtatta gtaggaggtg ttttagattg gagaagaaac tgaccataaa agatattgca
    19321 gaaatggctc agacctcgaa aacaaccgtg tcattttacc taaacgggaa atatgaaaaa
    19381 atgtcccaag agacacgtga aaagattgaa aaagttattc atgaaacaaa ttacaaaccg
    19441 agcattgttg cgcgtagctt aaactccaaa cgaacaaaat taattggtgt tttgattggt
    19501 gatattacca acagtttctc aacccaaatt gttaagggaa ttgaggatat cgccagccag
    19561 aatggctacc aggtaatgat aggaaatagt aactacagcc aagagagtga ggacaggtat
    19621 attgaaagca tgcttctctt gggagtagac ggctttatta ttcagcctac ctctaatttc
    19681 cgaaaatatt ctcgtatcat cgatgagaaa aagaagaaaa tggtcttttt tgatagtcgg
    19741 ctctatgaac accggactag ctgggtcaaa accaataact atgatgccgt ttatgatatg
    19801 acccagtcct gtatcgaaaa aggttatgag cattttctct tgattacagc ggatacgagt
    19861 cgtttgagta ctcggattga gcgggcaagt ggttttgtgg atgctttaac agatgctaat
    19921 atgcgccacg ctaggctaac cattgaagat aagcatacga atttggaaca aattaaggaa
    19981 tttttacaaa aagaaatcaa tcccgatgaa aaaactctgg tatttgttcc taactgttgg
    20041 gccctacctc cagtctttac cgttatcaaa gagttgaatt ataacttgcc acaagttggg
    20101 ttgattggtt ttgacaatac ggagtggact tgcttttctt ctccaagtgt ttcgacgttg
    20161 gttcagcccg cctttgaaga aggacaacag gctacaaaga ttttgattga ccagattgaa
    20221 ggcctcaatc aagaagaaag gcaacaagtc ttggattgta gtgtgagttg gaaagagtcg
    20281 actttctaag atgaaaggga aataactggc aacctctgtt aagaaataaa ataatcccat
    20341 ctagcatgaa ctggatggga ttatttgtct ataaaatgag aaattacggg agtaatctcc
    20401 taaatcaact atttttgatt tacttcttta actacttgat aaaagttata gaagtagacc
    20461 aaacttgaga tgatggttac gactaggaat attggaaatt tccattggat ggagtttctt
    20521 gattttcttg gttcaagact gaaaaatcgt atagtgaagt cattgcttac ttttctcctt
    20581 ctgtttggta tttttaggag ttttctcctc ctgaagtgat agaaatccgt aggtcagggt
    20641 tccgaaaata ctaccgataa tcaggccata catcaggaaa ggaccacttt tatcaaattg
    20701 catgagcaac tttccaaaat ctgaaaagga catctgctga acgaagactt tatgaaagat
    20761 gagtagggta aagaggccaa tctgaatacc gataaacaca acccagcttc ggaatttgat
    20821 ttgggctttg ctgtaggttt tgaggatgat ttctgacttg tcatcttttt ccaagtggag
    20881 ttctttgacg gctctttgag tttttaaggt aatgaaaaaa atgagtccag agtatacgta
    20941 gggcatggca tagcgaacgg cttctatgaa gcgtccaaat aatagataaa acaagaagag
    21001 gaagaaggaa gaataaacga tttgaaccat agaacgggca caagctttgt agataatctc
    21061 ttgtcggcat tcatcaaaag gaccctgaat atgaaagaga tttcgaagca ggcgagtggt
    21121 taagtcttct ttgttcatgc taataacctc ctaaatgagc agttttactg actttctttt
    21181 acgaattgat agagataata aagataagtg atagaagaaa ggctagcaat agtcagcagt
    21241 aaataatatt tccaatcgct tgatatgagc atcagttgtg gaaaagatag aatcataaag
    21301 tatagtgcta agttaagtgt gcgcgttttt ggggagtcaa tctttagata agtcagtcct
    21361 ttgttaaggg ctagaataaa gactagcacg aggaatgtct cgtcgattgg caagttccct
    21421 gaaatgatga tgaagatgag cagagaactg aacaaaagat gataggtaag taaagttagt
    21481 aatgatttca taaggcacct cctaatcctc atcctgatct tccttagctt ttgcaatgcg
    21541 acgggagatg agaaactgta tgctcgctcc gaagaaaata gaaccgagaa tgcttgatac
    21601 accatttctt atagtgagaa gagaatgaaa atagtcctga ccttcaccta tgagtatact
    21661 tagaagagga gttataaaaa acatccatag accaaagaac aaacctgctt taagacctgg
    21721 atagtatagt tgcttacttt ctttctcgct cagcatatct ggatcaatag ctgtaattcc
    21781 tgtttttttc attttgtagg tgacatagcc agcagcgatg agggcaatca ctaaaattag
    21841 aggaggatag attagagcca cttcttgagg gtatttatag gccagaagga gtggaataag
    21901 atttccgaaa atcatcagat aaaagaggat gataaagact tggttgccga tacgatcagc
    21961 ctcgcgtcgt ttgtgttcgt cgagagggcc agaaattccg tatatgcgtt tgatgagttt
    22021 ttcagtgaag gtttcttttt tcatgagttg gctccttttt taaaaattat cctcccaaaa
    22081 gagactattg aggtcagttt ggaggctgcg ggcgagattg agacagagtt ccagagttgg
    22141 gttgtacttg tcgttctcga tcatattgat ggtttgtctc gagacaccga tatccttggc
    22201 tagctcgagc tgggaaatac ccaattcctt gcgaaattct ttcacacgat tcatctggac
    22261 tcctttctga ttcatgtcgt atatatttga ctacattata ttcttctata gagtgaatgt
    22321 caagcatatt tgacatattt cttaaagaaa tcttactttt tttgccctat ttgtctgact
    22381 agtgcaagct agtcagattt gtggtaaaat agataagata tgacaaaaga atttcatcat
    22441 gtaacggtct tactccacga aacgattgat atgctcgacg taaagcctga cggtatctac
    22501 gttgatgcga ctttgggtgg agcgggccat agcgaatatt tattaagtaa attaagtgaa
    22561 aaaggacatc tctatgcctt tgatcaggat cagaatgcca ttgacaatgc gcaaaaacgt
    22621 ttggcacctt acattgagaa gggaatggtg acctttatca aggacaactt ccgtcattta
    22681 caggcacgtt tgcgcgaagc tggtgttcaa gaaattgatg gaatttgtta tgacttggga
    22741 gtgtctagcc ctcaattaga ccagcgtgag cgtggttttt cttataaaaa ggatgcgcca
    22801 ctagacatgc ggatgaatca ggatgctagc ctgacagcct atgaagtggt gaatcactat
    22861 gactatcatg acttggttcg tattttcttc aagtatggtg aggataaatt ctctaaacag
    22921 attgcccgta agattgaaca agcgcgtgaa gtcaagccaa ttgagactac gactgagtta
    22981 gcagagatta tcaagtcggc taaacctgcc aaggagctca agaagaaggg ccatcctgct
    23041 aagcagattt tccaggctat tcgaattgaa gtcaatgatg aactgggagc ggcagatgag
    23101 tccatccagc aggctatgga tatgttggct ctggatggta ggatttcagt gattaccttt
    23161 cattccttag aagaccgctt gaccaagcaa ttattcaagg aagcttcaac agttgaagtt
    23221 ccaaaaggct tgcctttcat cccagatgat ctcaagccca agatggaatt ggtagcccgt
    23281 aagccaatct tgccaagtgc agaagaatta gaagccaata accgctcgca ctcagccaag
    23341 ttgcgcgtgg ccagaaaaat tcacaagtaa gagggaaaaa ggatggcaga aagaatggaa
    23401 aaaacaggtc aaatactaca gatgcaactt aaacggtttt cgcgtgtgga aaaagctttt
    23461 tacttttcca ttgctgtaac cactcttatt gtggccatta gtattatttt tatgcagacc
    23521 aagctcttgc aagtgcagaa tgatttgaca aaaatcaatg cgcagataga ggaaaagaag
    23581 accgaattgg acgatgccaa gcaagaggtc aatgaactat tacgtgcaga acgtttgaaa
    23641 gaaattgcca attcacacga tttgcaatta aacaatgaaa atattcgaat agcggagtaa
    23701 gatatgaagt ggacaaaaag agtaatccgt tatgcgacga aaaatcggaa atcgccggct
    23761 gaaaacagac gcagagttgg aaaaagtctg agtttattat ctgtctttgt ttttgccgtt
    23821 tttttggtca attttgctgt tattatcggg agtggtagta aatttggaac agatctagtc
    23881 aaagaggcta agaaagttca ccaaataacc cgtacagtcc ctgccaaacg tgggactatt
    23941 tatgaccgaa atggagtccc gattgctgag gacgcaactt cctataatgt ctatgctgtt
    24001 attgataaaa aatacaaatc agcaacgggt aaaattcttt atgtagaaga tgcccagttt
    24061 aataaggtag cagaggtttt ccataagtat ctggatatgg acgaggctta tgttaaagaa
    24121 caattgtctc aacctaatct gacccaagtt tcctttggtg ccaaaggaaa tggaattacc
    24181 tatgccaata tgatggctat caaaaaagag ttggaaactg cagaggtcaa ggggattgat
    24241 tttacaacca gtcctaatcg tagttaccca aacggacaat ttgcttctag ttttatcggt
    24301 ctagctcaac tccatgaaaa tgaagatgga agcaagagtt tgctgggaac ttctggaatg
    24361 gagagttcct tgaacagtat tcttgcaggg aaagacggta ttattactta tgaaaaggat
    24421 cgtctgggta atattgtccc tggaacagaa caagtttccc aacaaacggt agatggcaag
    24481 gatgtttata caacattgtc tagtccgctc caatctttca tggaaactca gatggatgcc
    24541 tttctagaaa aagtaaaagg taagtatatg accgcgacct tggtcagtgc aaagaccggt
    24601 gaaatcctcg ctaccaccca acgacctacc tttaatgcag atactaaaga aggaatcact
    24661 gaggactttg tttggcgtga tattctttat caaagtaact atgaaccagg atcagccatg
    24721 aaggttatga cgttagcttc ttctattgat aataatacct tcccaagtgg agaatacttc
    24781 aatagcagtg aattcaaaat agcggatgcg acgactcgag attgggatgt taatgatggt
    24841 ttgactactg gtgggatgat gactttctta caaggtttcg ctcactccag taatgttgga
    24901 atgagtctac ttgaacaaaa aatgggagat gctacttggt tggattatct aaaacgcttt
    24961 aaatttgggg ttccaactcg ctttggcttg acagatgaat acgctggtca acttccagct
    25021 gataatattg ttagtattgc tcaaagctca tttgggcaag gaatttcagt gacacaaaca
    25081 caaatgcttc gtgcctttac agctattgct aatgatggag ttatgctgga gccaaaattt
    25141 ataagtgcta tttatgatac taacaatcag tctgtacgta agtcacaaaa agaaatagta
    25201 ggaaatcctg tttccaaaga ggcagcaagc acaactcgaa atcacatgat cttagttggg
    25261 acggaccctc tatatggaac tatgtataat cactacacag gaaagccaat tataacagtt
    25321 cctggacaaa atgtagcagt taaatccggt acggctcaaa tcgctgatga gaaaaatgga
    25381 ggatacttgg ttggttctac caattatatt ttctcagttg tgactatgaa tcctgctgaa
    25441 aatcctgatt ttatcttgta tgtaacggtt caacagcctg agcattattc aggtatccag
    25501 ttgggagaat ttgccacccc aatcttggag cgggcttcag ctatgaaaga atctctcaat
    25561 cttcaatctc cagccaaaaa tttagataaa gttacgacag aatcttctta tgcaatgcct
    25621 agcatcaagg atatttcacc tggtgagttg gcggaagcct tacgccgaaa tattgtgcaa
    25681 ccaatcgttg taggtactgg aacaaagatt aaagagactt ctgtagaaga agggaccaat
    25741 cttgcaccaa accaacaagt tctcctttta tcggataagg tagaagaaat tccagacatg
    25801 tatggctgga aaaaagagac tgccgagacc tttgctaaat ggttggatat tgaactggaa
    25861 tttgaaggtt caggttccgt tgttcagaag caagatgttc ggactaatac agctatcaaa
    25921 aacattaaaa aaattaaatt aactttagga gactaatatg tttatttcta ttagtgctgg
    25981 aattgtgaca tttttactaa ctttagtagg aattccggcc tttatccaat tttatagaaa
    26041 ggcgcaaatt acaggccagc agatgcatga ggatgttaaa cagcaccagg caaaagctgg
    26101 gactcctaca atggggggac ttgttttcct cattgctgca gttgtggtga gtttcctcgt
    26161 cgctcttttt tcgaaacaat tgaccaataa tgttggtatg attttgttta ttttggtctt
    26221 gtatggcttg gttggttttt tagatgactt tctcaaggtc ttccgaaaga tcaatgaggg
    26281 gctaaacccc aaacagaaat tggctcttca gctgctaggt ggcgtcattt tctacctttt
    26341 ttatgagcgt gggggcgata tgctctctgt ctttggctac caagtgcatt tagggatttt
    26401 ctatattatc ttcgctcttt tctggctagt tggtttttca aacgcagtca acttgacaga
    26461 tggtattgac ggtctagcta gtatttccgt tgtgattagt ttgtctgcct atggagttat
    26521 tgcctatgtg caaggccaga tggatattct cctggtgatt tttgccatga ttggtggttt
    26581 gcttggtttc ttcgtcttta accacaagcc tgccaaggtc tttatgggag atgtgggaag
    26641 tttggctctc ggtggaatgc tggcagctat ctctatggcc ctccaccaag aatggactct
    26701 cttgattatc ggaattgtgt atgtttttga aacaacttcg gtcatgatgc aagtcagcta
    26761 tttcaaactg acaggtggta aacgtatttt ccgtatgacg cctgtacatc accattttga
    26821 gcttggggga ttgtctggta aaggaaatcc ttggagcgag tggaaggttg acttcttctt
    26881 ttggggagtt gggcttctag caagtctcct gaccttcgca attttgtatt tgatgtaaga
    26941 atggcaccct gatgtttcag ggtgtttttg tgtttaaata cacaatgaaa atcaaagaac
    27001 aaactagaaa gctaacttta ggctgctcaa aacatagtag tttgaaacta gaatagtaca
    27061 catctacttc taaaatattg ttagaaatcg atttgactgt cctgatcgat ttgtcctgtt
    27121 cttatttcat tttaatatac agttttgagg ttgtagataa ggagaagctg atgtggtttg
    27181 aagaggtttt cgaagagtgt aaaaaaatat tggtcagtta aagtcaaaac tcttgacctt
    27241 ttctgaccaa tgtagtatat tatgaacgta aggtaaatga aagccttact agaacactta
    27301 tttaaagtaa aatagaaaga ggtgggtcta tgtttcatct agaaatcttc agaagtaaag
    27361 atagtctact cctgcttgaa aaagaaaaac cagaaatagt acgtagggta gcggtttagc
    27421 tagtctaaat tttttaaaac aaaggttaaa gatagtcaat atcagtaatc ataactaagt
    27481 aaacaaaaag aggtaaagaa tatgaataac aactttaata attttaataa catggatgat
    27541 ttatttaacc aattgatggg tggtatgcga ggatacagtt ctgaaaatcg ccgttactta
    27601 attaatggac gcgaagtcac acctgaggaa tttgctcact atcgtgcgac tggtcaatta
    27661 ccaggaaatg cagaaactga tgtgcaaatg ccacaacagg catcaggtat gaaacaagac
    27721 ggtgtccttg caaaactagg tcgaaactta acagcagaag cgcgtgaggg caagttggac
    27781 cctgttatcg gacgaaacaa ggaaattcaa gaaacatctg aaatcctctc acgccgcacc
    27841 aagaacaatc ctgttttggt cggagatgca ggtgttggta agacagcagt tgtcgaaggt
    27901 ctagcgcaag ccattgtgaa cggagatgtt cctgctgcta tcaagaacaa ggaaattatt
    27961 tctattgata tctcaggtct tgaggctggt actcaatacc gtggtagctt tgaagaaaat
    28021 gtccaaaact tagtcaatga agtgaaagaa gcagggaata ttatcctctt ctttgatgaa
    28081 attcaccaaa ttcttggtgc tggtagcact ggtggagaca gtggttctaa agggcttgcg
    28141 gatattctca agccagctct ctctcgtgga gaattgacag tgattggggc aacaactcaa
    28201 gacgaatacc gtaacaccat cttgaagaat gctgctcttg ctcgtcgttt caacgaagtg
    28261 aaggtcaatg ctccttcggc agagaatact tttaaaattc ttcaaggaat tcgtgacctc
    28321 tatcaacaac accacaatgt catcttgcca gacgaagtct tgaaagcagc ggtggattat
    28381 tctgttcaat acattcctca acgtagcttg ccagataagg ctattgacct tgtcgatgta
    28441 acggctgctc acttggcggc tcaacatcca gtaacagatg tgcatgctgt tgaacgagaa
    28501 atcgaaacgg aaaaagacaa gcaagaaaaa gcagttgaag cagaagattt tgaagcagct
    28561 ctaaactata aaacacgcat tgcagaattg gaaaggaaaa tcgaaaacca cacagaagat
    28621 atgaaagtga ctgcaagtgt caacgatgtg gctgaatctg tggaacgaat gacaggtatc
    28681 ccagtatcgc aaatgggagc ttcagatatc gaacgtttga aagatatggc tcatcgcttg
    28741 caagacaagg tgattggtca agataaggcc gtagaagttg tagctcgtgc tatccgtcgt
    28801 aaccgtgctg gttttgatga aggaaatcgc ccaatcggca acttcctctt tgtagggtct
    28861 actggggttg gtaagacgga gcttgctaag caattggcac tcgatatgtt tggaacccag
    28921 gatgcgatta tccgtttgga tatgtctgaa tacagtgacc gcacagctgt ttctaagcta
    28981 attggtacaa cagcaggcta tgtgggttat gatgacaata gcaatacctt aacagaacgt
    29041 gttcgtcgca atccatactc tatcattctc ttggatgaaa ttgaaaaggc tgaccctcaa
    29101 gttattaccc ttctcctcca agttctagat gatggtcgtt tgacagatgg tcaaggaaat
    29161 acagtaaact tcaagaacac tgtcattatt gcgacctcaa atgctggatt tggctatgaa
    29221 gccaacttga cagaagatgc ggataaacca gaattgatgg accgtttgaa acccttcttc
    29281 cgtccagaat tcctcaaccg ctttaatgca gtcatcgagt tctcacactt gactaaggaa
    29341 gacctttcta agattgtaga tttgatgttg gctgaagtta accaaacctt ggctaagaaa
    29401 gacattgact tggtagtcag tcaagcggct aaagattata tcacagaaga aggttacgac
    29461 gaagtcatgg gggttcgtcc tctccgtcgc gtggttgaac aagaaattcg tgataaggtg
    29521 acagacttcc acttggatca tttagatgct aaacatctgg aagcagatat gaaagatggc
    29581 gttttggtta ttcgtgagaa agcctaagac agaattttga ggataaaaaa gaaggagcca
    29641 gctgaaaaaa ctggttcctt ttgaggtacg acgggcatgt cgtatagtag aagtgtacta
    29701 ttctagtttc aatccactat agtagctcag aagtcggtac ttaaacgtgc tatatcaaaa
    29761 ccagtccttg aaaaacgtgg attggtttcg tgtttggatt attaccttga acgacatgcg
    29821 ttaaaagtta gttgaaccgc cgtatgccga acagcacgta cggtggtgtg agaggggcta
    29881 gagattatcc cctactcgat tttaaatcac atgacgttca aaggcatcat ctgaaatccc
    29941 ttgttccaag atgagttttg cccattcttt agcagagaag aggctgtggt ccttgtagtt
    30001 tccgcaagat tcgatggttg tccctgggac atcttcccaa gtagtagttt cagcgatttc
    30061 cttgagcgaa tccttgataa cagctgcgat tttagcactg gtgtgacgtc cccacataat
    30121 catgtggaag cctgtgcggc aaccaaatgg tgaacagtca atcatgccgt caatgcgggt
    30181 acggatgagt ttggctaaga ggtgctcgat agtgtgaagg ccggcggtag ggatagagtc
    30241 ttcgtttggt tgcaccaagc gaatatcata attggagatg atgtctcctt ttggtcctgt
    30301 ttcttcccca atcaagcgaa catagggtgc tttgacaatg gtgtggtcaa gttcaaaact
    30361 ttcgacaata acttcttttg acatggtaaa tcctttcagt tttcttctct cattatatca
    30421 taaaggttgc tcctgagaca gagagaaaac ctctccgagg ctggagaggt tgaaatcttt
    30481 acttacgata taagcggtcg tattggtagt atgggtcaaa ggttacgttg atacccagtt
    30541 tacgaaggac attcttgtct tcatcagtca agatgatggt tgagtgggct tcgcttcctt
    30601 tgaggttgcc gagttcttcc atagcgcggg cagcatcagg attttctgta gctgtgatag
    30661 caagtgcaat caggatttca tttgaatgaa ggcgtggatt gcggctaccg agatgatcga
    30721 ttttaagacc ttggattggc ttaacaactt caggttcgat tagttttact tctttagcga
    30781 tgtcagctga ttttttgatg gcgttgatca aggcagcggc tgtaggacca aagagttctg
    30841 agttcttacc agtgacgatt tccccatttg gcaattcaaa ggctagggct ggtccaccag
    30901 tttcttctgc tttttggcgc gcaacgacag caaccttacg gtcggcaggt gtgatgccga
    30961 ggtcgttcat aagcaactca attttcttga cggcagcttc gccaactttt tcagctttga
    31021 agtcaagaac ggtttgatag taacgacgga tgatttcttg tttagaagct tcgacagcag
    31081 cctcgtcatc tgtaatggca aaaccaacca tgttgacacc catatctgtc ggtgaagcgt
    31141 atggcgattt tccgagaata cgttccaaca tgcgcttgag cactgggaag atttcgatat
    31201 cacggttgta gttgacagtg gtttctccat aggtttgaag atggaagggg tcaatcatgt
    31261 tgacatcgtc aaggtcagct gtggcagctt cataagccaa gttaactgga tgatgaaggg
    31321 gaagattcca aacagggaag gtttcaaatt tagcgtagcc agacttgatg acattgattt
    31381 ggtcgtggta catattggac atacacgttg ccaattttcc agaaccgggt ccaggagcgg
    31441 ttacgacaat caagttgcga ctggttttga tgtagtcgtt tttgcccatg ccttcagggg
    31501 aaatgatgtg atccatatcc gtcggatagc ctttgattgg ataatgaaga taagaatcaa
    31561 ttccattttt ctcaagttgg ttgcggaagg catctgcagc gggctgacca gcgtattgtg
    31621 taatgacaac ggagccgaca aaaatcccca attcattgaa tttatcaatc aaacgaagaa
    31681 cttcttggtc gtaagaaatg cctaggtcgc cacgtgcttt ggaatgctct atgttgctag
    31741 cgttaatagc aatcacaacc tcaacttgct ctttcaactc ttgcaagagc ttgattttat
    31801 tgtcaggctc ataaccagga aggacacgag cagcgtggaa atcttctaac attttgccac
    31861 caaactctag gtaaagcttg ccgtcaaatt ggttaatgcg ctctaagatg tggtcgcgtt
    31921 gtagatttaa atattgttca gaactaaaag cttgtttttt cattttttta cctctggact
    31981 ctattataat aaaaaattgg aagttaggaa actacggagc taaaaaagaa attaaaaaga
    32041 ttaagcaaac gcttgcacaa aattttaaaa agtgctatca tatactatag attattaaaa
    32101 taatgaggta agaagatgca agaaaaatgg tggcataatg ccgtagtcta tcaagtctat
    32161 ccaaagagtt ttatggatag taatgaagat ggaattggcg atttgccagg aattaccagt
    32221 aagttggact atctagccaa gctaggaatc acagcaattt ggctttctcc cgtttatgac
    32281 agccctatgg atgataatgg ctatgatatt gctgattatc aagcgattgc ggctattttt
    32341 ggaaccatgg aggacatgga tcagctgatt gcagaagcta agaagcgtga tatccgtatc
    32401 atcatggact tggtggtcaa tcatacctcg gatgagcatg cctggtttgt agaggcctgt
    32461 gaaaatccta atagccctga gcgagactac tatatctggc gggatgagcc taacgattta
    32521 gattctatct ttagtgggtc tgcttgggaa tacgatgaaa agtcaggtca atactatctc
    32581 cactttttca gcaagaaaca gccggatctc aactgggaaa atgaaaaact tcgccagaaa
    32641 atttatgaga tgatgaactt ctggattgat aagggtattg gtggtttccg tatggatgtt
    32701 attgacatga ttggcaaaat tcctgacgag aaggtagtca ataatggtcc tatgctccat
    32761 ccctatctca aggaaatgaa tcaggcgacc tttggagata aggatctctt gacagtaggg
    32821 gagacttggg gagcaacgcc agagattgcc aagctctact ctgatccaaa ggggcaagaa
    32881 ttgtctatgg tcttccagtt tgaacatatc ggtcttcagt atcaggaagg tcagcctaaa
    32941 tggcactatc aaaaagagct gaatatcgct aagttaaaag aaatcttcaa caaatggcag
    33001 acagagttag gagttgagga cggttggaat tccctcttct ggaacaatca tgacctccct
    33061 cgtatcgtct caatctgggg aaatgaccaa gaataccgcg aaaaatctgc caaagccttt
    33121 gcaatcttgc ttcatcttat gagaggaact ccttatatct accaaggtga ggagattggg
    33181 atgaccaact atccgtttga aacactggat caagtagaag atattgaatc tctcaactat
    33241 gcgcgtgagg ctcttgaaaa aggtgttccg attgaagaaa tcatggacag tatccgtgtt
    33301 attggacgtg acaatgcccg tacccctatg caatgggacg agagcaaaaa tgctggtttc
    33361 tcaacaggtc aaccttggtt ggcggttaat ccaaattacg agatgatcaa tgtccaagaa
    33421 gcgctggcaa atccagattc tattttctat acctatcaaa aactggtcca aattcgcaag
    33481 gagaatagct ggctaattcg agctgacttt gaattgcttg atacggctga taaggtcttt
    33541 gcttatatac gtaaggatgg cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa
    33601 gagcaagact tgacagtaga aggaaaagtc aaatctgtct tgattgaaaa caccctagct
    33661 caagaagtct ttgaaaaaca aatcttagtt ccatgggatg ctttctgtgt ggaattacta
    33721 taaatatttt ttgcagaaaa atttaaaatt gaaatcgtat aaaaacaagg gaggactgta
    33781 taaaaggcag aaatcctttg ttttttataa ccaaggttta taaaccttca ttctcgaaat
    33841 tcaattaact ttacaaattc ccactattaa ggagaaagga gacgaacata aagaagcgta
    33901 tccttagtgc aggcctgact tttacatctg ctttgctttt agctgcttgc ggccaatcag
    33961 gttcagatac aaaaacttac tcatcaacct ttagtggaaa tccaactaca tttaactatc
    34021 tattagacta ttacgctgat aatatagtca attgaaacaa gaacaagaca aaagagcctc
    34081 ataaaaggta ttgcaacttg gtaatacctt ttacgaggct ttttgatgtg agcccatgtt
    34141 ttctcaatag gattgtgctc aggtgagtag ggaggaagag gtaaaaattt atgcccaaac
    34201 tcttcacaca agagttctag cttccccatt ctatggaatc ttacattatc cataataata
    34261 accgatggtg tggttaatgt tggtaagaga aacttctgaa accaagcttc aaaaaagtcg
    34321 ctcgtcatca tctcttcgta agtcattgga gcgattaact caccatttgt tagacctgca
    34381 accaaagaaa tcctctgata tcttcttcca gatactttgc ctcttcttaa ctgacctttt
    34441 aatgagcgac catattctcg ataaaaataa g
//
LOCUS       DAVHIZ010000018        34324 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.018, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000018 DAVHIZ010000000
VERSION     DAVHIZ010000018.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34324)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34324)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34324
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.018"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            463..915
                     /locus_tag="VVO18_000906"
     CDS             463..915
                     /locus_tag="VVO18_000906"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEU5586084.1"
                     /translation="MIITKISRLGTYVGVNPHFATLIDFLEKTGLENLTEGSIAIDGN
                     RLFGNCFTYLADGQAGAFFETHQKYLDIHLVLENEEAMAVTSPENVSVTQEYDEEKDI
                     ELYTGKVEQLVHLRAGECLITFPEDLHQPKVRINDEPVKKVVFKVAIS"
     gene            934..2271
                     /locus_tag="VVO18_000907"
     CDS             934..2271
                     /locus_tag="VVO18_000907"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="HEU5586085.1"
                     /translation="MKKMRKFLCLAGIALAAVALVACSGKKEATTSTEPPTELSGEIT
                     MWHSFTQGPRLESIQKSADAFMQKHPKTKIKIETFSWNDFYTKWTTGLANGNVPDIST
                     ALPNQVMEMVNSDALVPLNDSIKRIGQDKFNETALNEAKIGDDYYSVPLYSHAQVMWV
                     RTDLLKEHNIEVPKTWDQLYEASKKLKEAGVYGLSVPFGTNDLMATRFLNFYVRSGGG
                     SLLTKDLKADLTSQLAQDGIKYWVKLYKEISPQDSLNFNVLQQATLFYQGKTAFDFNS
                     GFHIGGINANSPQLIDSIDAYPIPKIKESDKDQGIETSNIPMVVWKNSKHPEVAKAFL
                     EALYNEEDYVKFLDSTPVGMLPTIKGISDSAAYKENETRKKFKHAEEVITEAVKKGTA
                     IGYENGPSVQAGMLTNQHIIEQMFQDIITNGTDPMKAAKEAEKQLNDLFEAVQ"
     gene            2350..3234
                     /locus_tag="VVO18_000908"
     CDS             2350..3234
                     /locus_tag="VVO18_000908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999669.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5586086.1"
                     /translation="MVKERNLTRWIFVLPAMIIVGLLFVYPFFSSIFYSFTNKHLIMP
                     NYKFVGLANYKAVLSDPNFFNAFFNSIKWTVFSLVGQVLVGFVLALALHRVRHFKKLY
                     RTLLIVPWAFPTIVIAFSWQWILNGVYGYLPNLIVKLGLMEHTPAFLTDSTWAFLCLV
                     FINIWFGAPMIMVNVLSALQTVPEEQFEAAKIDGASSWQVFKFIVFPHIKVVVGLLVV
                     LRTVWIFNNFDIIYLITGGGPANATTTLPIFAYNLGWGTKLLGRASAVTVLLFIFLVA
                     ICFIYFAIISKWEKEGRK"
     gene            3234..4067
                     /locus_tag="VVO18_000909"
     CDS             3234..4067
                     /locus_tag="VVO18_000909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250560.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU5586087.1"
                     /translation="MKKKSSIYLDILSHVLLVGATIVAIFPLVWIIISSVKGKGELTQ
                     YPTRFWPEQFTLDYFTHVINDLHFIDNIRNSLIIALATTLIAIIISAMAAYGIVRFFP
                     KLGAIMSRLLVITYIFPPILLAIPYSIAIAKVGLTNSLFGLMMVYLSFSVPYAVWLLV
                     GFFQTVPIGIEEAARIDGANKFVTFYKVVLPIVAPGIVATAIYTFINAWNEFLYALIL
                     INNTGKMTVAVALRSLNGSEILDWGDMMAASVIVVLPSIIFFSIIQNKIASGLSEGSV
                     K"
     gene            4085..6178
                     /gene="nanB"
                     /locus_tag="VVO18_000910"
     CDS             4085..6178
                     /gene="nanB"
                     /locus_tag="VVO18_000910"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="neuraminidase NanB"
                     /protein_id="HEU5586088.1"
                     /translation="MNKRGLYSKLGISVVGISLLMGVPTLIHANELNYGQLSISPIFQ
                     GGSYQLNNKSIDISPLLLDKLSGESQTVVMKFKADKPNSLQALFGLSNSKAGFKNNYF
                     SIFMRDSGEIGVEIRDAQKGINYLFSRPASLWGKHKGQAVENTLVFVSDSKDKTYTMY
                     VNGIEVFSETVDTFLPISNINGIDKATLGAVNREGKEHYLAKGSIDEISLFNKAISDQ
                     EVSNIPLSNPFQLIFQSGDSTQANYFRIPTLYTLSSGRVLSSIDARYGGTHDSKSKIN
                     IATSYSDDNGKTWSEPIFAMKFNDYEEQLVYWPRDNKLKNSQISGSASFIDSSIVEDK
                     KSGKTILLADVMPAGIGNNNANKADSGFKEINGHYYLKLKKNGDNDFRYTVRENGVVY
                     DETTNKPTNYTINDKYEVLEGGKSLTVEQYSVDFDSGSLRERHNGKQVPMNVFYKDSL
                     FKVTPTNYIAMTTSQNRGESWEQFKLLPPFLGEKHNGTYLCPGQGLALKSSNRLIFAT
                     YTSGELTYLISDDSGQTWKKSSASIPFKNATAEAQMVELRDGVIRTFFRTTTGKIAYM
                     TSRDSGETWSEVSYIDGIQQTSYGTQVSAIKYSQLIDGKEAVILSTPNSRSGRKGGQL
                     VVGLVNKEDDSIDWKYHYDIDLPSYGYAYSAITELPNHHIGVLFEKYDSWSRNELHLS
                     NVVQYIDLEINDLTK"
     gene            6191..7294
                     /locus_tag="VVO18_000911"
     CDS             6191..7294
                     /locus_tag="VVO18_000911"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000241731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEU5586089.1"
                     /translation="MVKYGVVGAGYFGAELARYMQKNDGAEITLLYDPDNAEAIAEEL
                     GAKVASSLDELVSSDEVDCVIVATPNNLHKEPVIKAAQNGKNVFCEKPIALSYQDCRE
                     MVDACKENNVTFMAGHIMNFFNGVHHAKELINQGVIGDVLYCHTARNGWEEQQPSVSW
                     KKIREKSGGHLYHHIHELDCVQFLMGGMPETVTMTGGNVVHEGEHFGDEDDMIFVNME
                     FSNKRFALLEWGSAYRWGEHYVLIQGSKGAIRLDLFNCKGTLKLDGQESYFLIHESQE
                     EDDDRTRIYHSTEMDGAIAYGKPGKRTPLWLSSVIDKEMRYLHEIMEGAPVSEEFAKL
                     LTGEAALEAIATADACTQSMFEDRKVKLSEIVK"
     gene            7468..8166
                     /locus_tag="VVO18_000912"
     CDS             7468..8166
                     /locus_tag="VVO18_000912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398897.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmannosamine-6-phosphate 2-epimerase"
                     /protein_id="HEU5586090.1"
                     /translation="MPQISKEALIEQIKDGIIVSCQALPHEPLYTEAGGVIPLLVKAA
                     EQGGAVGIRANSVRDIKEIKEVTKLPIIGIIKRDYPPQEPFITATMKEVDELAELDIE
                     VIALDCTKRERYDGLEIQEFIRQVKEKYPNQLLMADTSIFEEGLAAVEAGIDFVGTTL
                     SGYTSYSPKVDGPDFELIKKLCDAGVDVIAEGKIHTPEQAKQILEYGVRGIVVGGAIT
                     RPKEITERFVASLK"
     gene            8185..9702
                     /locus_tag="VVO18_000913"
     CDS             8185..9702
                     /locus_tag="VVO18_000913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477452.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU5586091.1"
                     /translation="MFKVLQKVGKAFMLPIAILPAAGLLLGIGGALSNPTTIATYPIL
                     DNSIFQSIFQVMSSAGEVVFSNLSLLLCVGLCIGLAKRDKGTAALAGVTGYLVMTATI
                     KALVKLFMAEGSAIDTGVIGALVVGIVAVYLHNRYNNIQLPSALGFFGGSRFVPIVTS
                     FSSILIGFVFFVIWPPFQQLLVSTGGYISQAGPIGTFLYGFLMRLSGAVGLHHIIYPM
                     FWYTELGGVETIAGQTVVGAQKIFFAQLADPAHSGLFTEGTRFFAGRFSTMMFGLPAA
                     CLAMYHSVPKNRRKKYAGLFFGVALTSFITGITEPIEFMFLFVSPVLYVVHAFLDGVS
                     FFIADVLNISIGNTFSGGVIDFTLFGILQGNAKTNWVLQIPIGLIWSVLYYIIFRWFI
                     TQFNVLTPGRGEEVDSKEISESADSTSNTADYLKQDSLQIIRALGGSNNIEDVDACVT
                     RLRVAVKEVNQVDKALLKQIGAVDVLEVKGGIQAIYGAKAILYKNSINEILGVDD"
     gene            9827..11155
                     /locus_tag="VVO18_000914"
     CDS             9827..11155
                     /locus_tag="VVO18_000914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672126.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586092.1"
                     /translation="MKFRKLACTVLAGAAVLGLAACGNSGGSKDAAKSGGDGAKTEIT
                     WWAFPVFTQEKTGDGVGTYEKSIIEAFEKANPDIKVKLETIDFKSGPEKITTAIEAGT
                     APDVLFDAPGRIIQYGKNGKLAELNDLFTDEFVKDVNNENIVQASKAGDKAYMYPISS
                     APFYMAMNKKMLEDAGVANLVKEGWTTDDFEKVLKALKDKGYTPGSLFSSGQGGDQGT
                     RAFISNLYSGSVTDEKVSKYTTDDPKFVKGLEKATSWIKDNLINNGSQFDGGADIQNF
                     ANGQTSYTILWAPAQNGIQAKLLEASKVEVVEVPFPSDEGKPALEYLVNGFAVFNNKD
                     DKKVAASKKFIQFIADDKEWGPKDVVRTGAFPVRTSFGKLYEDKRMETISGWTQYYSP
                     YYNTIDGFAEMRTLWFPMLQSVSNGDEKPADALKAFTEKANETIKKAMKQ"
     gene            11408..12274
                     /locus_tag="VVO18_000915"
     CDS             11408..12274
                     /locus_tag="VVO18_000915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5586093.1"
                     /translation="MRETVISYAFLAPVLFFFVIFVLAPMVMGFITSFFNYSMTKFEF
                     VGLDNYIRMFKDPVFTKSLINTVILVIGSVPVVVLFSLFVASQTYHQNVIARSFYRFV
                     FFLPVVTGSVAVTVVWKWIYDPLSGILNFVLKSSHIISQNISWLGDKNWALMAIMIIL
                     LTTSVGQPIILYIAAMGNIDNSLVEAARVDGATEFQVFWKIKWPSLLPTTLYIAIITT
                     INSFQCFALIQLLTSGGPNYSTSTLMYYLYEKAFQLTEYGYANTIGVFLAVMIAIVSF
                     VQFKVLGNDVEY"
     gene            12290..13129
                     /locus_tag="VVO18_000916"
     CDS             12290..13129
                     /locus_tag="VVO18_000916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU5586094.1"
                     /translation="MQSTEKKPLTAFTVISTIILLLLTVLFIFPFYWILTGAFKSQPD
                     TIVIPPQWFPKMPTMENFQQLMVQNPALQWMWNSVFISLVTMFLVCATSSLAGYVLAK
                     KRFYGQRILFAIFIAAMALPKQVVLVPLVRIVNFMGIHDTLWAVILPLIGWPFGVFLM
                     KQFSENIPTELLESAKIDGCGEIRTFWSVAFPIVKPGFAALAIFTFINTWNDYFMQLV
                     MLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGA
                     VKG"
     gene            13402..13854
                     /locus_tag="VVO18_000917"
     CDS             13402..13854
                     /locus_tag="VVO18_000917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000575445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhcH/YjgK/YiaL family protein"
                     /protein_id="HEU5586095.1"
                     /translation="MIFDDLKNITFYKGIHPNLDKAIDYLYQHRKDSFELGKYEIDGD
                     KVFLVVQENVLNQVENNQFEHHKNYADLHLLVEGHEYSSYGSRIKDEAVAFDEASDIG
                     FVHCHEHYPLLLGYHNFAIFFPGEPHQPNGYAGMEEKVRKYLFKILID"
     gene            13996..14304
                     /locus_tag="VVO18_000918"
     CDS             13996..14304
                     /locus_tag="VVO18_000918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586096.1"
                     /translation="MDGQGITVDEMAWIIRGIVNALIGRYIKLGTYAAKYGISMARSI
                     LNRAAATAAARVGLLTKIFGWILRIAVLAADVYGNFANNIAAAWDAHDKIPNNGRINF
                     "
     gene            14591..15235
                     /locus_tag="VVO18_000919"
     CDS             14591..15235
                     /locus_tag="VVO18_000919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000057467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEU5586097.1"
                     /translation="MSQKGRSLIKAAFDTDNFLMRISEKVLDIVTVNLLFVVTCLPIV
                     TIGVAKISLYETMFEVKKSRRVPVFRTYLRVFRQNLKLGFQLGMLELGIVFLTLSDLY
                     LFWGQTALPFQLVKAICLGILIFLTIVMLASYPIAARYDLSWKEVLQKGLILASFNFP
                     WFFLMLAILVLIVMILYLSAFTLLLGGSAFILFGFGLLAFLQVGVMEKLFAKYE"
     gene            15409..16326
                     /locus_tag="VVO18_000920"
     CDS             15409..16326
                     /locus_tag="VVO18_000920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002894436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="HEU5586098.1"
                     /translation="MSDLKKYEGVIPAFYACYDDQGEVSPERTRALVQYFIDKGVQGL
                     YVNGSSGECIYQSVEDRKLILEEVMAVAKGKLTIIAHVACNNTKDSMELARHAESLGV
                     DAIATIPPIYFRLPEYSVAKYWNDISSAAPNTDYVIYNIPQLAGVALTPSLYTEMLKN
                     PRVIGVKNSSMPVQDIQTFVSLGGEDHIVFNGPDEQFLGGRLMGAKAGIGGTYGAMPE
                     LFLKLNQLIADKDLETARELQYAINAIIGKLTAAHGNMYGVIKEVLKINEGLNIGSVR
                     SPLTPVTEEDRPAVEAAAALIRETKERFL"
     gene            16344..17228
                     /locus_tag="VVO18_000921"
     CDS             16344..17228
                     /locus_tag="VVO18_000921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398633.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU5586099.1"
                     /translation="MTHYVAIDIGGTNIKYGLIDQEGQLVESYEMPTEAYKGGPHILQ
                     KTKDIVASYLEKGPVAGVAISSAGMVDPDKGEIFYAGPQIPNYAGTQFKKEIEESFTI
                     PCEIENDVNCAGLAEAVSGSGKGASVTLCLTIGTGIGGCLIMDGKVFHGFSNSACEVG
                     YMHMQDGAFQDLASTTALVEYVATAHGDPVDQWNGRRIFKEATEGNKFCMEGIDRMVD
                     YLGKGLANICYVANPEVVILGGGIMGQEAILKPKIRTALKEALVPSLAEKTRLEFAHH
                     QNTAGMLGAYYHFKTKQS"
     gene            complement(17244..18095)
                     /locus_tag="VVO18_000922"
     CDS             complement(17244..18095)
                     /locus_tag="VVO18_000922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398632.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="HEU5586100.1"
                     /translation="MDKPDIATVIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVT
                     QKLHISQAALTRFAKKCGFTGYREFIFQYQHEAENQANQVSKHSPLTKRVLRSYSNMR
                     EQTQDLIDEVQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQD
                     GFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPSKDSPIYTET
                     VLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRR
                     QKRVRKS"
     gene            18289..20346
                     /gene="pbp2b"
                     /locus_tag="VVO18_000923"
     CDS             18289..20346
                     /gene="pbp2b"
                     /locus_tag="VVO18_000923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein 2B"
                     /protein_id="HEU5586101.1"
                     /translation="MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNK
                     DFYEKKLASASQTKVTTSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKEIA
                     KKLLTYVSISSPNLTERQLADYYLADPEIYKKTVEALPSEKRLDSDGNRLSESELYNN
                     AVDSVPTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMP
                     GISISTSWDRKVLETSLSSIVGSVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQ
                     YEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFN
                     SELGNGGAKYSEGVYAVALNPKTGAVLSMSGLKHDLKTGDLTPDSLGTVTNVFVPGSV
                     VKAATISSGWENGVLSGNQTLTDQPIVFQGSAPIYSWYKLAYGSFPITAVEALEYSSN
                     AYMVQTALGIMGQTYQPNMFVGTSNLETAMGKLRATFGEYGLGAATGIDLPDESTGFV
                     PKEYSFANYITNAFGQFDNYTPMQLAQYVATIANDGVRVAPRIVEGIYGNNDKGGLGD
                     LIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTA
                     ESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYH
                     PMN"
     gene            20357..20953
                     /gene="recR"
                     /locus_tag="VVO18_000924"
     CDS             20357..20953
                     /gene="recR"
                     /locus_tag="VVO18_000924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination protein RecR"
                     /protein_id="HEU5586102.1"
                     /translation="MLYPTPIAKLIDSYSKLPGIGIKTATRLAFYTIGMSADDVNEFA
                     KNLLSAKRELTYCSICGRLTDDDPCSICTDPTRDQTTILVLEDSRDVAAMENIQEYHG
                     LYHVLHGLISPMNGISPDDINLKSLMTRLMDSEVSEVIVATNATADGEATSMYLSRLL
                     KPAGIKVTRLARGLAVGADIEYADEVTLLRAIENRTEL"
     gene            21129..22172
                     /locus_tag="VVO18_000925"
     CDS             21129..22172
                     /locus_tag="VVO18_000925"
                     /EC_number="6.3.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000814683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-alanine--D-alanine ligase"
                     /protein_id="HEU5586103.1"
                     /translation="MKQTIILLYGGRSAEREVSVLSAESVMRAVNYDRFTVKTFFISQ
                     SGDFIKTQEFSHAPGQEDRLMTNETIDWDKKVAPSAIYEEGAVVFPVLHGPMGEDGSV
                     QGFLEVLKMPYVGCNILSSSLAMDKITTKRVLESAGIAQVPYVAIVEGDDVTAKIAEV
                     EEKLAYPVFTKPSNMGSSVGISKSENQEELRPALELAFRYDSRVLVEQGVNAREIEVG
                     LLGNYDVKSTLPGEVVKDVAFYDYDAKYIDNKITMDIPAKISDDVVAVMRQNAETAFR
                     AIGGLGLSRCDFFYTDKGEIFLNELNTMPGFTQWSMYPLLWDNMGISYPELIERLVDL
                     AKESFDKREAHLI"
     gene            22256..23629
                     /locus_tag="VVO18_000926"
     CDS             22256..23629
                     /locus_tag="VVO18_000926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778684.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-
                     alanine ligase"
                     /protein_id="HEU5586104.1"
                     /translation="MKLTIHEIAQVVGVKNDISIFEDTQLEKAEFDSRLIGTGDLFVP
                     LKGARDGHDFIETAFENGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDV
                     FAVTGSNGKTTTKDMLAHLLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMG
                     QDHLGDIHLLSELARPKTAIVTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAP
                     ADPIVEDYLPTDKKVVRFGQGAELEITDLVERKDSLTFKANFLEQALDLPVTGKYNAT
                     NAMIASYVALQEGVSEEQIRLAFQDLELTRNRTEWKKAANGADILSDVYNANPTAMKL
                     ILETFSAIPANEGGKKIAVLADMKELGNQSVQLHNQMILSLSPDVLDTVIFYGEDIAE
                     LAQLASQMFPIGHVYYFKKTEDQDQFEDLVKQVKESLGAYDQILLKGSNSMNLAKLVE
                     SLENEDK"
     gene            23616..24227
                     /locus_tag="VVO18_000927"
     CDS             23616..24227
                     /locus_tag="VVO18_000927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU5586105.1"
                     /translation="MKTSDFVKYLQRMIAITDTGLTFTKDPFDRERYEDLRDLLSEML
                     NQGSDLDSEEVAEVLKPTSAYATPLMDVRAWIVEDEKICLVRGQGEDSWALPGGFGEV
                     GYSPTENILKEIEEETGFKAKVERLLAVFDTNRFQLQSKQYTKFVFGCKLLDGQFQEN
                     QEIADLQFFAIDQLPNLSEKRITKEQIELLWQVYQGHRGQYLD"
     gene            24318..25022
                     /locus_tag="VVO18_000928"
     CDS             24318..25022
                     /locus_tag="VVO18_000928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001055242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR02206 family membrane protein"
                     /protein_id="HEU5586106.1"
                     /translation="MNLWDIFFTTQATEPPKFDLFWYVSLFTLLALTFYTAHRYREKK
                     VYQRFFQILQTVQLILLYGWYWVNHMPLSESLPFYHCRMAMFVVLLLPGQSKYKQYFA
                     LLGTFGTLAAFVYPVPDAYPFPHITILSFIFGHLALLGNSLVYLLRQYNARLLDVKGI
                     FLMTFALNALIFVVNLVTGGDYGFLTKPPLVGDHGLVANYLLVSIVLVATISLTKKIL
                     EFFLAQEAEKMIAKEA"
     gene            25241..26614
                     /gene="ftsA"
                     /locus_tag="VVO18_000929"
     CDS             25241..26614
                     /gene="ftsA"
                     /locus_tag="VVO18_000929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000090410.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsA"
                     /protein_id="HEU5586107.1"
                     /translation="MAREGFFTGLDIGTSSVKVLVAEQRNGELNVIGVSNAKSKGVKD
                     GIIVDIDAAATAIKSAISQAEEKAGISIKSVNVGLPGNLLQVEPTQGMIPVTSDTKEI
                     TDQDVENVVKSALTKSMTPDREVITFIPEEFIVDGFQGIRDPRGMMGVRLEMRGLLYT
                     GPRTILHNLRKTVERAGVQVENVIISPLAMVQSVLNEGEREFGATVIDMGAGQTTVAT
                     IRNQELQFTHILQEGGDYVTKDISKVLKTSRKLAEGLKLNYGEAYPPLASKETFQVEV
                     IGEVEAVEVTEAYLSEIISARIKHILEQIKQELDRRRLLDLPGGIVLIGGNAILPGMV
                     ELAQEVFGVRVKLYVPNQVGIRNPAFAHVISLSEFAGQLTEVNLLAQGAIKGENDLSH
                     QPISFGGMLQKTAQFVQSTPVQPAPAPEVEPVAPTEPMADFQQASQNKPKLADRFRGL
                     IGSMFDE"
     gene            26631..27890
                     /gene="ftsZ"
                     /locus_tag="VVO18_000930"
     CDS             26631..27890
                     /gene="ftsZ"
                     /locus_tag="VVO18_000930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000144288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein FtsZ"
                     /protein_id="HEU5586108.1"
                     /translation="MTFSFDTAAAQGAVIKVIGVGGGGGNAINRMVDEGVTGVEFIAA
                     NTDVQALSSTKAETVIQLGPKLTRGLGAGGQPEVGRKAAEESEETLTEAISGADMVFI
                     TAGMGGGSGTGAAPVIARIAKDLGALTVGVVTRPFGFEGSKRGQFAVEGINQLREHVD
                     TLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITNPGLINLDFADVKTV
                     MANKGNALMGIGIGSGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDLTLIEA
                     EEASQIVNQAAGQGVNIWLGTSIDESMRDEIRVTVVATGVRQDRVEKVVAPQARTATN
                     YRETVKPAHSHGFDRHFDMAETVELPKQNPRRLEPTQASAFGDWDLRRESIVRTTDSV
                     VSPVERFEAPISQDEDELDTPPFFKNR"
     gene            27895..28566
                     /locus_tag="VVO18_000931"
     CDS             27895..28566
                     /locus_tag="VVO18_000931"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggS family pyridoxal phosphate-dependent
                     enzyme"
                     /protein_id="HEU5586109.1"
                     /translation="MNVKENTELVFREVAEASLSAHRESGSVSVIAVTKYVDVPTAEA
                     LLPLGVHHIGENRVDKFLEKYEALKDRDVTWHLIGTLQRRKVKDIIQYVDYFHALDSV
                     KLAGEIQKRSDRVIKCFLQVNISKEESKHGFSREELLEILPELARLDKIEYVGLMTMA
                     PFEASSEQLKEIFKAAQDLQREIQEKQIPNMPMTELSMGMSRDYKEAIQFGSTFVRIG
                     TSFFK"
     gene            28576..29115
                     /locus_tag="VVO18_000932"
     CDS             28576..29115
                     /locus_tag="VVO18_000932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053379.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein SepF"
                     /protein_id="HEU5586110.1"
                     /translation="MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTSVNSSQEPALP
                     MNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAG
                     NESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRL
                     PDEDQQGEFGFDMKRNRVR"
     gene            29115..29378
                     /locus_tag="VVO18_000933"
     CDS             29115..29378
                     /locus_tag="VVO18_000933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YggT family protein"
                     /protein_id="HEU5586111.1"
                     /translation="MIFLIRMIYNAVDIYSLILVAFAVMSWFPGAYESSLGRWIVALV
                     KPVLAPLQRLPLQIAGLDLSVWVAIVLVRFLGENLVRFLAMIG"
     gene            29375..30160
                     /locus_tag="VVO18_000934"
     CDS             29375..30160
                     /locus_tag="VVO18_000934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398113.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding protein"
                     /protein_id="HEU5586112.1"
                     /translation="MNKGIYQHFSIEDRPFLDKGMEWIKKVEDSYAPFLTPFINPHQE
                     KLLKILAKTYGIACSSSGEFVSSEYVRVLLYPDYFQPEFSDFEISLQEIVYSNKFEHL
                     THAKILGTVINQLGIERKLFGDILVDEERAQIMINQQFLLLFQDGLKKIGRIPVSLEE
                     RPFTEKIDKLEQYRELNLSVSSFRLDVLLSNVLKLSRNQANQLIEKKLVQVNYHVVDK
                     SDYTVQVGDLISVRKFGRLRLFQDKGQTKKEKKKITVQLLLSK"
     gene            30169..30957
                     /gene="divIVA"
                     /locus_tag="VVO18_000935"
     CDS             30169..30957
                     /gene="divIVA"
                     /locus_tag="VVO18_000935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIVA"
                     /protein_id="HEU5586113.1"
                     /translation="MPITSLEIKDKTFGTRFRGFDPEEVDEFLDIVVRDYEDLVRANH
                     DKNLRIKSLEERLSYFDEIKDSLSQSVLIAQDTAERVKQAAHERSNNIIHQAEQDAQR
                     LLEEAKYKANEILRQATDNAKKVAVETEELKNKSRVFHQRLKSTIESQLAIVESSDWE
                     DILRPTATYLQTSDEAFKEVVSEVLGEPIPAPIEEEPIDMTRQFSQAEMEELQARIEV
                     ADKELSEFEAQIKQEVETPTPVVSPQVEEEPLLIQLAQCMKNQK"
     gene            31305..34097
                     /locus_tag="VVO18_000936"
     CDS             31305..34097
                     /locus_tag="VVO18_000936"
                     /EC_number="6.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000155.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isoleucine--tRNA ligase"
                     /protein_id="HEU5586114.1"
                     /translation="MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEDAKLYQRRQELN
                     QGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIE
                     QVLSKQGVKRKEMDLVEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPDYE
                     AAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGK
                     GVLDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGEARKFVVAAELLTSLSEK
                     FGWADVQVLETYRGQELNHIVTEHPWDTAVEELVILGDHVTTDSGTGIVHTAPGFGED
                     DYNVGIANNLEVAVTVDERGIMMKNAGPEFEGQFYEKVVPTVIEKLGNLLLAQEEISH
                     SYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDEIEKVKFHSEWGKVRLYNMIRDRGD
                     WVISRQRAWGVPLPIFYAEDGTAIMVAETIEHVAQLFEEHGSSIWWERDAKDLLPEGF
                     THPGSPNGEFKKETDIMDVWFDSGSSWNGVVVNRPELTYPADLYLEGSDQYRGWFNSS
                     LITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTS
                     VDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMT
                     IRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQ
                     MQTVFYDILVKITKLLTPILPHTAEEIWSYLEFEAEDFVQLSELPEAQTSANQEEILD
                     TWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIV
                     SELTIAEEPTPEAALSFEDVAFTVERAAGEVCDRCRRIDPTTAERSYQAVICDHCASI
                     VEENFADAVAEGFEEK"
BASE COUNT        10567 a         6053 c         7462 g        10242 t
ORIGIN      
        1 tagtgctaga ataatagatt agaattattt tagaaaaacg aagtgagcag cttataaatt
       61 caagtcccca aatagattca tactagtatc ttttgcaaaa aataaagggc gacttccttc
      121 atgaatatca atttcatcta taaggaaggt agctaattga actaacttat ttattctgtt
      181 tgtcgctaga aaaatcagac ctccttgtga agattgagga gatactgaat gaaaatcaaa
      241 gaagaaacta gcaagctagt agcagattgc ccaaaacacc gctttgaggt tgtagataag
      301 actgacctat ataatccaag gtgaagcgac tgtggtttga agagattttc aaagagtata
      361 ggctagagag tagtgttttt atgtccttct agtagaaaat gctagacaga agaatgggga
      421 acttggatag gaaaaataga ttgagaaagg aggttagaag agatgattat tacaaaaatt
      481 agccgtttag gaacttatgt gggagtaaat ccacattttg caacattaat agattttcta
      541 gaaaaaacag gactagaaaa tttaacagaa ggttcgattg ctatcgatgg taatcgattg
      601 tttgggaatt gctttactta tctagcagat ggtcaagcag gggctttctt tgaaacacac
      661 caaaaatatt tggatattca tttagttttg gaaaacgaag aagccatggc tgttacatcg
      721 ccggaaaatg taagcgttac ccaagaatat gatgaagaga aagatattga attatacaca
      781 gggaaagtgg aacagttggt tcatttgaga gctggcgaat gcctcatcac ttttccagaa
      841 gatttacatc aacccaaggt tcgtataaat gatgaacctg tgaaaaaagt tgtctttaaa
      901 gttgcgattt cttaatgtag aaagagaaga acgatgaaaa aaatgagaaa gtttttatgt
      961 ctagctggaa ttgcgctagc ggctgttgcc ttggtagctt gttcaggaaa aaaagaagct
     1021 acaactagta ctgaaccacc aacagaatta tctggtgaga ttacaatgtg gcactccttt
     1081 actcaaggac cccgtttaga aagtattcaa aaatcagcag atgctttcat gcaaaagcat
     1141 ccaaaaacga aaatcaagat tgaaacattt tcttggaatg acttctatac taaatggact
     1201 acaggtttag caaatggaaa tgtgccagat atcagtacag ctcttcctaa ccaagtaatg
     1261 gaaatggtca actcagatgc tttggttccg ctaaatgatt ctatcaagcg tattggacaa
     1321 gataaattta acgaaactgc cttaaatgaa gcaaaaatcg gagatgatta ctactctgtt
     1381 cctctttatt cacatgcaca agtcatgtgg gttagaacag atttgttaaa agaacataat
     1441 attgaggttc ctaaaacttg ggatcaactc tatgaagctt ctaaaaaatt gaaagaagct
     1501 ggagtttatg gcttgtctgt tccgtttgga acaaatgact taatggcaac acgtttcttg
     1561 aacttctacg tacgtagtgg tggaggaagc ctcttaacaa aagatcttaa agcagacttg
     1621 acaagccaac ttgctcaaga tggtattaaa tactgggtta aattgtataa agaaatctca
     1681 cctcaagatt ctttgaactt taatgtcctt caacaagcta ccttgttcta tcaaggaaaa
     1741 acagcatttg actttaactc tggcttccat atcggaggaa ttaatgccaa cagtcctcaa
     1801 ttgattgatt cgattgatgc ttatcctatt ccaaaaatca aagagtctga taaagaccaa
     1861 ggaattgaaa cctcaaacat tccaatggtt gtttggaaaa attcaaaaca tccagaagtt
     1921 gctaaagcat tcttagaagc actttataat gaagaagact acgttaaatt ccttgattca
     1981 actccagtag gtatgttgcc aactattaag gggattagcg attctgcagc ctataaagaa
     2041 aatgaaactc gtaagaagtt taaacatgct gaagaagtaa ttactgaagc tgttaaaaaa
     2101 ggtactgcta ttggttatga aaatggacca agtgtacaag ctggtatgtt gactaaccaa
     2161 cacattattg aacaaatgtt ccaagatatc attacaaatg gaacagatcc tatgaaagca
     2221 gcaaaagaag cagaaaaaca attaaacgat ttatttgagg ctgttcagta gatgtaaaag
     2281 actagaaaat aggtgggcta gtgagctgaa aagctctagc ccaatcttgt aaaagaaggg
     2341 agaaggagaa tggttaaaga acgtaattta actcgctgga tatttgtttt gccagctatg
     2401 attatcgtag gattactctt tgtttatccg tttttctcga gtatttttta tagctttacc
     2461 aataagcatt tgattatgcc taattataaa tttgttggtt tggctaacta taaagctgtg
     2521 ctatcagatc ccaacttctt taatgcgttc tttaattcaa ttaagtggac cgttttctca
     2581 ttagttggtc aagttttagt agggtttgta ttggctttag ctcttcacag agtacgccac
     2641 ttcaagaaat tatataggac cttattgatt gttccttggg catttcctac aatcgttatt
     2701 gccttctctt ggcagtggat tctaaacggg gtttatggct acttacctaa tctaatcgta
     2761 aaattaggtt taatggaaca tacacctgca tttttgacag atagtacatg ggcattccta
     2821 tgtttggtgt ttatcaacat ttggtttgga gcaccaatga ttatggttaa tgtgctttca
     2881 gctttgcaaa cagtaccaga agaacaattt gaggctgcta agatagatgg tgcttcaagt
     2941 tggcaggtgt tcaagtttat cgtctttcca catattaaag tggttgtagg acttctagtt
     3001 gttttgagaa ctgtatggat ctttaataac tttgacatta tctacctcat tactggtggt
     3061 ggaccagcca atgctacaac gacgcttcca atttttgctt acaacctggg ttggggaact
     3121 aaattgttgg gtcgtgcttc agcagttaca gtattgctct ttatcttctt ggtggcgatt
     3181 tgctttatct actttgctat catcagtaag tgggaaaagg agggtagaaa ataatgaaga
     3241 agaaatccag tatttattta gatattctct cacatgtact tttagttggt gcgaccatcg
     3301 ttgcaatttt cccattggta tggattatca tatcttctgt caaagggaaa ggggaattaa
     3361 ctcagtatcc aacacgattt tggcctgaac agtttacatt agattatttc actcatgtta
     3421 tcaacgattt gcacttcatt gataacattc gaaacagttt aatcattgcc ttggctacaa
     3481 ccctcattgc gattattatt tctgctatgg cagcctatgg tattgttcga ttctttccta
     3541 aattgggagc aatcatgtcg agactactcg tcattaccta cattttccca ccaattttgt
     3601 tagcaattcc ctattcaatt gccattgcta aagttgggtt aacaaatagt ttatttggct
     3661 tgatgatggt ttatctatct tttagtgttc catatgcagt ttggctctta gttggatttt
     3721 tccaaacagt tccaattgga attgaagaag cggctagaat tgatggtgca aataaatttg
     3781 ttacgtttta taaggttgtg ctaccgattg tagcaccagg tattgtagca acagctattt
     3841 atacatttat caatgcttgg aatgaattcc tgtatgcctt gattttgatt aacaatacag
     3901 gaaagatgac agtagcagta gcccttcgtt cacttaatgg ttcagaaata ctagactggg
     3961 gagatatgat ggcagcgtct gttattgtag ttcttccatc aattattttc ttctctatca
     4021 tccaaaataa gattgcaagt ggattatcag aaggatctgt gaagtagacg aaagaaggaa
     4081 aaaaatgaat aaaagaggtc tttattcaaa actaggaatt tctgttgtag gcattagtct
     4141 tttaatggga gtccccactt tgattcatgc gaatgaatta aactatggtc aactgtccat
     4201 atctcctatt tttcaaggag gttcatatca actgaacaat aagagtatag atatcagccc
     4261 tttgttatta gataaattgt ctggagagag tcagacagta gtaatgaaat ttaaagcaga
     4321 taaaccaaac tctcttcaag ctttgtttgg cctatctaat agtaaagcag gttttaaaaa
     4381 taattacttt tcaattttca tgagagattc tggtgagata ggtgtagaaa taagagacgc
     4441 ccaaaaggga ataaattatt tattttctag accagcttca ttatggggaa agcataaagg
     4501 acaggcagtt gaaaatacac tagtatttgt atctgattct aaagataaaa catacacaat
     4561 gtatgttaat ggaatagaag tgttctctga aacagttgat acatttttgc caatttcaaa
     4621 tataaatggt atagataagg caacactagg agctgttaat cgtgaaggta aggaacatta
     4681 cctcgcaaaa ggaagtattg atgaaatcag tctatttaac aaagcaatta gtgatcagga
     4741 agtttcaaat attcccttgt caaatccctt tcagttaatt ttccaatcag gagattctac
     4801 tcaagctaac tattttagaa taccgacact atatacatta agtagtggaa gagttctatc
     4861 aagtattgat gcacgttatg gtgggactca tgattctaaa agtaagatta atattgccac
     4921 ttcttatagt gatgataatg ggaaaacgtg gagtgagcca atttttgcta tgaagtttaa
     4981 tgactatgag gagcagttag tttactggcc acgagataat aaattaaaga atagtcaaat
     5041 tagtggaagt gcttcattca tagattcatc cattgttgaa gataaaaaat ctgggaaaac
     5101 gatattacta gctgatgtta tgcctgcggg tattggaaat aataatgcaa ataaagccga
     5161 ctcaggtttt aaagaaataa atggtcatta ttatttaaaa ctaaagaaga atggagataa
     5221 cgatttccgt tatacagtta gagaaaatgg tgtcgtttat gatgaaacaa ctaataaacc
     5281 tacaaattat actataaatg ataagtatga agttttggag ggaggaaagt ctttaacagt
     5341 cgaacaatat tcggttgatt ttgatagtgg ctctttaaga gaaaggcata atggaaaaca
     5401 ggttcctatg aatgttttct acaaagattc gttatttaaa gtgactccta ctaattatat
     5461 agcaatgaca actagtcaga atagaggaga gagttgggaa caatttaagt tgttgcctcc
     5521 gttcttagga gaaaaacata atggaactta cttgtgtcct ggacaaggtt tagcattaaa
     5581 atcaagtaac agattgattt ttgcaacata tactagtgga gaactaacct atctcatttc
     5641 tgatgatagt ggtcaaacat ggaagaaatc ctcagcttca attccgttta aaaatgcaac
     5701 agcagaagca caaatggttg aactgagaga tggtgtgatt agaacattct ttagaaccac
     5761 tacaggtaag atagcttata tgactagtag agattctgga gaaacatggt cggaagtttc
     5821 gtatattgat ggaatccaac aaacttcata tggcacacaa gtatctgcaa ttaaatactc
     5881 tcaattaatt gatggaaaag aagcagtcat tttgagtaca ccaaattcta gaagtggccg
     5941 taagggaggt caattagttg tcggtttagt caataaagaa gatgatagta ttgattggaa
     6001 ataccactat gatattgatt tgccttcgta tggttatgcc tattctgcga ttacagaatt
     6061 gccaaatcat cacataggtg tactgtttga aaaatatgat tcgtggtcga gaaatgaatt
     6121 gcatttaagc aatgtagttc agtatataga tttggaaatt aatgatttaa caaaataaag
     6181 gagaaaaaac atggttaaat acggtgttgt tggagcaggg tattttggag ctgaattggc
     6241 tcgctatatg caaaagaatg atggagcaga gattactctt ctctatgatc cagataatgc
     6301 agaggcgatt gcagaagaat tgggagcaaa agtagcaagt tccttagatg agttggtttc
     6361 tagcgatgaa gtagattgtg ttatcgtcgc aactccaaat aatcttcata aggaaccggt
     6421 tattaaggct gcacagaatg gtaaaaatgt tttctgtgaa aaaccaattg cgctttctta
     6481 tcaagattgt cgcgagatgg tagatgcatg taaagaaaac aatgtaacct ttatggcagg
     6541 acatattatg aatttcttta atggtgttca tcatgcaaaa gaactcatta atcaaggagt
     6601 tatcggagac gttctatatt gtcatacagc tcgtaatggt tgggaagaac aacaaccgtc
     6661 agtatcatgg aaaaaaattc gtgaaaaatc aggtggtcac ttgtatcacc acatccatga
     6721 attggattgc gttcaattcc ttatgggggg catgcctgaa actgtaacca tgacaggtgg
     6781 aaatgtggtc catgaaggtg aacatttcgg tgatgaagat gatatgattt ttgtcaatat
     6841 ggaattttct aataagcgtt ttgccttgtt agaatggggt tcagcttatc gttggggtga
     6901 acattatgtc ttaatccaag gaagcaaagg tgccatccgc ttagacttat tcaactgtaa
     6961 aggaactctt aagctagatg ggcaagaaag ctatttcttg attcacgaat cgcaagaaga
     7021 agatgatgat cggactcgta tctatcatag tacagagatg gatggagcaa ttgcttatgg
     7081 taaaccaggt aaacgtactc cattatggct atcatctgtc attgataaag aaatgcgcta
     7141 tctgcatgag attatggaag gagctccagt atcagaagaa tttgcaaaac ttttgacagg
     7201 tgaagctgcc ctagaagcaa ttgctactgc agatgcttgt acccagtcta tgtttgaaga
     7261 tcgcaaagta aaattgtcag aaattgtaaa ataaattttg gtattctcct atttataggt
     7321 cgacttgctc ctctgaaagt acttttagag gagctgtttg actttgctag tttttgaaac
     7381 tgaaatctat tatactacaa actattgaaa gcgttttaat tttaaggtat aataatctca
     7441 tagaaataaa gaaaaggagg aaagaggatg ccacagatta gcaaagaagc cttgattgag
     7501 caaatcaaag atggaatcat cgtttcttgt caggctcttc ctcatgaacc gctttataca
     7561 gaagcgggag gggtgattcc cttgctggtc aaagcggctg agcaaggtgg ggcagtcggt
     7621 atccgagcaa acagtgttcg cgatatcaag gaaattaagg aagtcactaa acttccaatc
     7681 attgggatta tcaaacgtga ttatccacct caggaaccct tcatcacggc tactatgaaa
     7741 gaagttgatg aattggcaga actggacatc gaggtgattg ctctggattg taccaagcgt
     7801 gaacgctacg atggtttgga aattcaagag ttcattcgtc aggttaagga gaaatatcct
     7861 aatcagcttt tgatggctga tactagtatc ttcgaagaag ggctagcagc tgtagaagca
     7921 ggaattgact ttgtcggaac aaccttatca ggctacacat cctacagtcc aaaagtagac
     7981 ggtccagatt ttgaattgat taagaaactc tgtgatgccg gtgtagatgt cattgcagaa
     8041 ggaaaaattc atacaccaga acaagccaaa caaatccttg aatatggagt gcgaggcatc
     8101 gttgttggtg gcgctattac tagaccaaaa gagattacag aacgcttcgt tgctagtctt
     8161 aaataagatg tgagggggag ttttatgttt aaagttttac aaaaagttgg aaaagctttt
     8221 atgttaccta tagctatact tcctgcagca ggtctacttt tggggattgg tggtgcactt
     8281 tcaaacccaa ccacgatagc aacttatcca atactagaca atagtatttt tcaatcgata
     8341 ttccaagtaa tgagctctgc aggagaggtt gtattcagta atttgtcact acttctctgt
     8401 gtgggattat gtattggctt agcgaaacga gataaaggaa ccgctgcgtt agcaggagta
     8461 actggttact tagttatgac tgcaacgatc aaagctttgg taaaactttt tatggcagaa
     8521 ggatctgcaa ttgatactgg agttattgga gcattagttg tcggaatagt tgccgtatat
     8581 ttgcacaacc gatataacaa tattcaatta ccttccgctt taggattctt tggaggttca
     8641 cgcttcgttc ctattgttac atcgttctct tctatcttga ttggctttgt cttctttgtt
     8701 atttggccac ctttccaaca acttcttgtt tctacaggtg gatatatttc tcaggcgggt
     8761 ccaattggaa cttttctata tggattttta atgagacttt ctggagcagt aggcttacat
     8821 catataattt accctatgtt ttggtatact gaacttggtg gtgttgaaac tattgcagga
     8881 caaacagtgg ttggagctca aaaaatattt tttgctcaat tagccgatcc ggcccattct
     8941 ggattattta cagaaggaac aaggtttttt gcaggtcgtt tctcaacaat gatgttcggt
     9001 ttaccggctg cctgtttagc gatgtaccat agtgttccta aaaatcgtcg taaaaaatac
     9061 gcgggtttgt tttttggagt tgctttaaca tcttttatta ccggtattac agaaccaatt
     9121 gaatttatgt ttctattcgt cagtccggtt ctatatgttg ttcacgcatt ccttgatggt
     9181 gttagcttct ttattgcaga cgtcttaaat atttcaatag gaaacacatt ttcaggaggt
     9241 gtaatcgatt tcacattatt tggaattttg caggggaacg ctaagacgaa ttgggttctt
     9301 cagattccaa ttggacttat ttggagtgtt ttgtattata ttatttttag atggttcatt
     9361 actcaattca acgttctaac gccaggacga ggagaagaag tagattctaa agaaatttct
     9421 gaatccgcag attcaacttc aaatactgca gattatttaa aacaggatag cctacaaatt
     9481 atcagagcct tgggtggatc aaataatata gaagatgtag atgcttgtgt gacacgttta
     9541 cgtgtagctg taaaagaagt taatcaagtt gataaagcac ttttaaaaca aattggtgca
     9601 gttgatgtct tagaagtgaa gggtggcatt caagcaatct atggagcaaa agcaatctta
     9661 tataaaaata gtattaatga aattttaggt gtagatgatt aagtacttac tgacttaata
     9721 aaaaacagag gagagtgatg gatgagtagg atgaaatgaa atcgcataca agaaataaag
     9781 aactcattat ccaagttgga tacgcttatt acataggaga atacaaatga aatttagaaa
     9841 attagcttgt acagtacttg cgggtgctgc ggttcttggt cttgctgctt gtggcaattc
     9901 tggcggaagt aaagatgctg ccaaatcagg tggtgacggt gccaaaacag aaatcacttg
     9961 gtgggcattc ccagtattta cccaagaaaa aactggtgac ggtgttggaa cttatgaaaa
    10021 atcaatcatc gaagcgtttg aaaaagcaaa cccagatata aaagtgaaat tggaaaccat
    10081 cgacttcaag tcaggtcctg aaaaaatcac aacagccatc gaagcaggaa cagctccaga
    10141 cgtactcttt gatgcaccag gacgtatcat ccaatacggt aaaaacggta aattggctga
    10201 gttgaacgac ctcttcacag atgaatttgt taaagatgtc aacaatgaaa acatcgtaca
    10261 agcaagtaaa gctggagaca aggcttatat gtatccgatt agttctgccc cattctacat
    10321 ggcaatgaac aagaaaatgt tagaagatgc tggagtagca aaccttgtaa aagaaggttg
    10381 gacaactgat gattttgaaa aagtattgaa agcacttaaa gacaagggtt acacaccagg
    10441 ttcattgttc agttctggtc aagggggaga ccaaggaaca cgtgccttta tctctaacct
    10501 ttatagcggt tctgtaacag atgaaaaagt tagcaaatat acaactgatg atcctaaatt
    10561 cgtcaaaggt cttgaaaaag caactagctg gattaaagac aatttgatca ataatggttc
    10621 acaatttgac ggtggggcag atatccaaaa ctttgccaac ggtcaaacat cttacacaat
    10681 cctttgggca ccagctcaaa atggtatcca agctaaactt ttagaagcaa gtaaggtaga
    10741 agtggtagaa gtaccattcc catcagacga aggtaagcca gctcttgaat atcttgtaaa
    10801 cgggtttgca gtattcaaca ataaagacga caagaaagtc gctgcatcta agaaattcat
    10861 ccagtttatc gcagatgaca aggagtgggg acctaaagac gtagttcgta caggtgcttt
    10921 cccagtccgt acttcatttg gaaaacttta tgaagacaaa cgcatggaaa caatcagtgg
    10981 ctggactcaa tactactcac catactacaa cactattgat ggatttgctg aaatgagaac
    11041 actttggttc ccaatgttgc aatctgtatc aaatggtgac gaaaaaccag cggatgcttt
    11101 gaaagccttc actgaaaaag caaacgaaac aatcaaaaaa gctatgaaac aatagtcctt
    11161 agttattcta tgaaaaagta attttttaaa gaacctaaga gtgtataccc ccttttccct
    11221 ctacacagat agtgtaagaa aagggggctt ttgtttaaaa tgtaagaaac tgtcacgaaa
    11281 ttaaaatgaa gttcttacat aagcgaacca taaaaaattt cattttgatt ttaaaacagt
    11341 tcaagaaagt caaaaaatta ttctatttga aagagaggtg ccgactgtga aagtcaataa
    11401 aatccgtatg cgggaaacag tgatttccta cgctttccta gcaccagtat tattcttctt
    11461 tgtcatcttt gtgttggctc cgatggtgat gggcttcatt acaagtttct ttaactactc
    11521 aatgactaaa tttgagtttg taggcttgga taactatatc cgtatgttta aagatcctgt
    11581 ctttacaaaa tctctgatta acacagttat tttggttatt ggatctgtac cagttgttgt
    11641 tctattctca ctctttgtag catctcagac ctatcatcaa aatgtcattg ccagatcctt
    11701 ctaccgtttc gtcttcttcc ttcctgttgt aacgggtagt gttgccgtga cagttgtttg
    11761 gaaatggatt tatgacccac tatcagggat tctaaacttt gtccttaagt caagccacat
    11821 catcagccaa aacatttctt ggttgggaga taaaaactgg gcattgatgg cgattatgat
    11881 tattctcttg accacttcag ttggtcagcc catcatcctt tatatcgctg ccatggggaa
    11941 tattgacaat tcactggttg aagcggcgcg tgttgatggt gcaactgagt ttcaagtttt
    12001 ttggaagatt aaatggccaa gccttcttcc aacaactctt tatattgcaa tcatcacaac
    12061 aattaactca ttccagtgtt tcgccttgat tcagcttttg acatctggtg gtccaaacta
    12121 ctcaacaagt accttgatgt actaccttta cgaaaaagcc ttccaattga cagaatacgg
    12181 ctatgccaac acaattggtg tcttcttggc agtcatgatt gctatcgtaa gctttgttca
    12241 atttaaagta cttggaaacg acgtagaata ctaaagaaag gagacagcta tgcaatctac
    12301 agaaaaaaaa ccattaacag cctttactgt tatttcaaca atcattttgc tcttgttgac
    12361 tgtgctgttc atctttccat tctactggat tttgacaggg gcattcaaat cacaacctga
    12421 tacaattgtt attcctcctc agtggttccc taaaatgcca accatggaaa acttccaaca
    12481 actcatggtg cagaaccctg ccttgcaatg gatgtggaac tcagtattta tctcattggt
    12541 aaccatgttc ttagtttgtg caacctcatc tctagcaggt tatgtattgg ctaaaaaacg
    12601 tttctatggt caacgcattc tatttgctat ctttatcgct gctatggcgc ttccaaaaca
    12661 agttgtcctt gtaccattgg tacgtatcgt caacttcatg ggaatccacg atactctctg
    12721 ggcagttatc ttgcctttga ttggatggcc attcggtgtc ttcctcatga aacagttcag
    12781 tgaaaatatc cctacagagt tgcttgaatc agctaaaatc gacggttgtg gtgagattcg
    12841 taccttctgg agtgtagcct tcccgattgt gaaaccaggg tttgcagccc ttgcaatctt
    12901 taccttcatc aatacttgga atgactactt catgcagttg gtaatgttga cttcacgtaa
    12961 caatttgacc atctcacttg gggttgcgac catgcaggct gaaatggcaa ccaactatgg
    13021 tttgattatg gcaggagctg cccttgctgc tgttccaatc gtcacagtct tcctagtctt
    13081 ccaaaaatcc ttcacacagg gtattactat gggagcggtc aaaggataat actctgcgaa
    13141 aatcgaatgc aaactacgtc agcttcacct tgccatactt aagtattgcc tgtggttagc
    13201 ttcctagttt gttcttcaat tttcattgag tataggaaaa tcaatctatc aaaatacaga
    13261 agtatatttt atagatttag agaatataga agttataagt gtctacaaaa tggagggcat
    13321 gcagttactt tatgaagttt tgtcagacac ttatcaactt aagaatggtt ttagttaact
    13381 atcagaaacg aaggaaagag tatgattttt gacgatttga aaaacatcac cttttacaaa
    13441 gggattcatc ccaatttaga caaggctatc gactatctct accaacatcg taaagattca
    13501 ttcgaattag gaaagtatga gattgatgga gataaagtct ttctagttgt tcaggaaaat
    13561 gtcctcaatc aagttgagaa taatcaattt gaacaccata agaactatgc agatttgcat
    13621 ttgctggtag aaggacatga atattcgagc tacggttcac gtatcaaaga cgaggcagta
    13681 gcattcgacg aagcgagtga cattggcttt gttcattgtc atgaacacta cccactcttg
    13741 ttgggttatc acaattttgc gattttcttc ccaggtgagc cacatcagcc aaatggttat
    13801 gcaggcatgg aagaaaaggt tcgaaaatat ctctttaaaa ttttgattga ttaaaaatag
    13861 gatgaattgt ttttttgtaa agctttgaca atactctacc atgaaattga tctttgtgag
    13921 gtagggaaat gagaataaaa tatttaaaaa ttggtatctt cttgtcagtc tgtgtatgct
    13981 acaagagcta gtttcttgga tggacaggga attacagttg atgagatggc ttggataatt
    14041 aggggcattg tgaatgcatt gattggtaga tacataaaat taggtactta tgcggctaag
    14101 tatggtatta gtatggcgcg ttctatctta aatagggcag ctgcaactgc ggcagcaaga
    14161 gtaggattat tgactaagat ttttggatgg attttacgaa tagctgtgct cgcagctgat
    14221 gtatatggta attttgccaa caatattgct gcagcttggg atgcacatga taaaatccct
    14281 aacaatggtc gtataaactt ttaaaatgcg agaatgaaag cactttgtat ttttttattg
    14341 aatatgttag cttggacagt gcttgcaatg atagtccgtg gagggctaga tggatttaat
    14401 gagcatactt ggagtactat tttaattgct tcgctgtccg ggatatatat agattatatg
    14461 tccatagata aaaatagaaa aaagtccaaa agaaaaaaga aaaaatagct ttgttcatgg
    14521 tagggactta tgaaagcttt actgataaaa aagaaaacag tttacaaaga aaaatgatgg
    14581 aggagcaaac atgtcacaaa aaggaagaag tctcatcaag gctgcatttg atacagataa
    14641 ttttctcatg cgaattagtg agaaggtttt agatattgta acagtcaatc ttctctttgt
    14701 agtaacttgt ttgccaatcg taacgattgg agtggctaaa atcagcctct acgagaccat
    14761 gttcgaagtt aagaagagca gacgtgttcc agtttttaga acctatctaa gagttttcag
    14821 gcaaaatctg aaactaggtt ttcagttggg gatgttagaa ttaggaattg tatttctaac
    14881 tctttcagat ctctatcttt tctggggtca aacagctctg cccttccaat tggtgaaagc
    14941 tatttgtcta ggtattctga ttttcctcac tattgtgatg ttggctagtt accctatcgc
    15001 ggcacgttat gacctatctt ggaaagaagt gttacaaaaa gggcttatct tggcaagttt
    15061 taactttcct tggttcttcc tcatgttagc cattcttgtc ctcattgtga tgattctata
    15121 tctatcagcc tttacccttc tattgggagg atcagctttt attctctttg gttttggact
    15181 ccttgctttt ttacaagtag gagtgatgga aaagctattt gctaagtatg agtaagggtt
    15241 gcaattattt ctgaaactac tttcaaacgt cccaaacgct attctataag caagaaacta
    15301 aaatctaagt gtctacaaga tattgaaagc cttttcggta aagtgtatac taaagaagta
    15361 aagaaagaat ctgctttagc agaaaataaa aataatagga gaaaatctat gtcagatttg
    15421 aaaaaatacg aaggtgtcat tccagccttc tacgcatgtt atgatgatca aggagaagta
    15481 agtccagagc gtacgcgtgc cttggttcaa tacttcattg ataaaggtgt tcaaggtctt
    15541 tatgtcaatg gttcttctgg tgaatgtatc taccaaagcg ttgaagatcg caagttaatt
    15601 ttggaagaag tcatggcagt tgccaagggt aaattgacca tcattgctca cgttgcttgc
    15661 aacaatacca aagatagtat ggaacttgct cgccacgcag aaagcttggg tgtagatgcc
    15721 attgcaacga ttccaccaat ttacttccgc ttgccagaat actcagttgc taaatattgg
    15781 aacgatatca gttctgcagc tccaaataca gactacgtga tttataacat tcctcaattg
    15841 gcaggggttg ctttgactcc aagcctttac acagaaatgt taaaaaatcc acgtgttatc
    15901 ggtgttaaaa attcttcaat gccagttcaa gatatccaaa cctttgtgag ccttggtggg
    15961 gaagatcata tcgtctttaa tggtccagat gaacagttcc taggtggccg ccttatgggt
    16021 gctaaggctg gtatcggtgg tacttatggt gctatgccag aactcttctt gaaactcaat
    16081 cagttgattg ctgacaagga cttggaaaca gcgcgtgagt tgcagtatgc tatcaatgct
    16141 atcattggta aactcactgc tgcacatgga aatatgtacg gtgtcatcaa agaagttttg
    16201 aaaatcaatg aaggcttgaa tattggttct gttcgttcac cattgacacc agtgactgaa
    16261 gaagatcgcc cagctgtaga agcagctgca gccttgattc gtgaaaccaa ggagcgcttc
    16321 ctctaatcca taaggaggta tttatgacac actacgttgc aattgatata ggtggaacca
    16381 acatcaaata tggtttgatc gaccaagaag gccaacttgt tgaatcgtat gaaatgccaa
    16441 ctgaggcgta taagggtgga cctcatatct tacaaaaaac caaagatatc gtagccagct
    16501 atttagaaaa aggcccagta gcaggtgttg ccatttcttc tgctgggatg gtggatccgg
    16561 ataagggaga aattttctat gctgggcctc aaatccctaa ctacgcaggt actcagttca
    16621 aaaaggaaat cgaagaaagc tttactattc cttgtgagat tgaaaatgat gtcaactgtg
    16681 caggtctggc tgaagcggta tctggttcag gcaagggagc aagtgtgacc ctttgcttga
    16741 ccattggaac aggtatcggt ggttgcttga ttatggatgg gaaggttttc catggattta
    16801 gcaattcggc ctgtgaagtc ggttatatgc atatgcaaga tggagctttt caagacttgg
    16861 cttctacgac agcattggtg gagtatgtag caacagctca tggcgatcca gttgatcagt
    16921 ggaatggccg acgcattttc aaggaagcca ctgaaggcaa taaattctgc atggaaggta
    16981 ttgaccgcat ggtagactat ctaggaaaag gtctggcaaa tatttgctac gttgccaatc
    17041 cagaagtggt cattctcggt ggtggtatca tggggcaaga agctattctc aaacccaaga
    17101 tccgtacagc cttgaaagag gccttggtac caagcctagc tgaaaaaaca cgattagaat
    17161 ttgcccatca ccagaataca gcagggatgt tgggagcata ttatcatttt aagacaaaac
    17221 aatcctagtt tggtttaacc aaactaggat tttcttacac gtttttgtct acgatagccg
    17281 ttgagttttt tattttccca gtagctatta aagatttttt ccttgctttc gcgattgatt
    17341 tccaaaaagt aggcataaat caaatcgata aagaagagca taggaagttg agcggatatt
    17401 cgttggatat aggaaggctg gctgtgggtg gctacaagaa cagtctctgt atagatcggg
    17461 ctatctttac tgggaacact tgaaaagagt acagtctttg cccccatctc cttggcatct
    17521 aataaactgt ctaaaataga gggagttgtg ccagaaagtg agaaaccaag tacgagacaa
    17581 ttttcatcca taatgcttgt tgtccaggca aagccatctt ggtctgtcaa agcttcgcag
    17641 accaccccca gacgcatgaa ccgcaatttc atttcacggg caacaaggcc agaactccct
    17701 gttccgaaga agtagatacg ctcagcatct tcgattaact gggcaattcg ttctagttgg
    17761 acttcgtcaa tcaagtcttg tgtttgttcc ctcatattgc tataacttct gaggactcgt
    17821 ttggtcagtg gactgtgctt ggagacttgg ttggcttgat tttctgcctc atgttggtat
    17881 tggaaaataa attctcggta gccagtaaag ccacactttt tagcaaagcg ggtcaaagca
    17941 gcttgagaaa tatgtaattt ttgggtgact tgttgagaag ataaatcatc tgtaatcgtt
    18001 tcagcttgca aaaaatagcg agcgatttct tgctctaggt ctgtcatttc ttcaaaatgt
    18061 gaatcaatga cagttgcgat atctggtttg tccataggga aggctccttt aaatgagtcg
    18121 tgttggaaaa agactagatt attgaacttt tacattcatt ataacatata atatagggat
    18181 ggataaataa aaacgtatct tactgtaaaa acgaaaaaaa gcttcttact tttccataat
    18241 tttctgctca aattgtggta caattaagag taagatttta agttagaaat gagactgatt
    18301 tgtatgagaa aatttaacag ccattcgatt ccgattcggc ttaatttatt gttttcaatc
    18361 gtcattttac tctttatgac cattattggt cgtttgttgt atatgcaggt tttgaacaag
    18421 gatttttatg aaaaaaagct agcctcagct agtcagacca aggtcacaac cagttctgct
    18481 cgtggggaaa tctatgatgc tagtggaaaa cctttggtag aaaatacgtt aaagcaggtt
    18541 gtttccttta cgcgtagcaa taaaatgacg gctacagact taaaagaaat agctaaaaag
    18601 ttactgactt atgtgagcat cagttcgcca aatttgacag aacgccagct ggctgattac
    18661 tatttggctg atcctgaaat ctataaaaaa acagtggaag ctctcccaag tgagaaacga
    18721 ttggattcag atggcaatcg cctatccgaa tcagaactgt ataacaatgc ggtcgatagt
    18781 gtcccaacaa gtcaactaaa ctatacagag gatgaaaaga aagaaatcta tctttttagt
    18841 cagttaaatg ctgttggaaa ctttgcgaca ggaaccattg cgacagatcc tctaaatgat
    18901 tctcaggtgg ctgttattgc ctctatttca aaggagatgc ctggcattag tatttctacc
    18961 tcttgggata gaaaggtttt ggaaacttct ctttcttcta tagtagggag tgtatccagt
    19021 gaaaaagctg gtctcccagc ggaagaagca gaagcctatc ttaaaaaagg ctattctcta
    19081 aatgaccgtg ttgggacttc ttacctggaa aaacaatacg aggaaacctt acaaggaaaa
    19141 cgctcggtaa aagaaatcca tctggataaa tatggcaata tggaaagcgt ggatacaatt
    19201 gaggaaggta gtaagggaaa caatatcaaa ctgaccattg atttggcctt ccaagatagc
    19261 gtggatgctt tgctgaaaag ttatttcaat tccgagctag gaaatggtgg agctaagtat
    19321 tctgaaggcg tgtatgcagt cgcccttaac cccaaaacag gtgctgtttt gtctatgtca
    19381 ggactcaaac atgacctgaa aacgggagac ttgacgcctg attccttggg aacggtaacc
    19441 aatgtctttg tcccagggtc agtagttaag gccgctacca tcagctcagg ttgggaaaat
    19501 ggtgttttat caggaaacca aaccttaaca gatcagccta ttgttttcca aggttcagct
    19561 ccaatttatt cttggtataa attggcatat ggatcttttc ctattacagc tgtggaagcc
    19621 ttggagtatt catctaatgc ttacatggtt caaaccgctc ttggaatcat gggccagacc
    19681 tatcaaccaa atatgtttgt tggaaccagc aatttggaaa cagctatggg aaaacttcgt
    19741 gcgacctttg gcgaatatgg cttgggggct gcgaccggaa ttgacctacc agatgaatct
    19801 actggatttg ttcccaaaga gtatagcttt gctaattaca ttactaatgc ctttgggcag
    19861 tttgataact atacgccgat gcagttggct cagtatgtag caactattgc aaatgatggt
    19921 gttcgtgtgg ctcctcgtat tgttgaaggc atttatggta ataatgataa gggaggactg
    19981 ggtgacttga ttcagcaact gcaaccgaca gagatgaata aggtcaatat atccgactcc
    20041 gatatgagca tcttgcacca aggtttttat caggttgccc atggtactag tggattgaca
    20101 actggacgtg ccttttcaaa tggcgccttg gtatccatta gcggaaaaac aggtacagcc
    20161 gaaagctatg tggcagatgg tcagcaagca accaatacca atgcggtggc ctatgcccca
    20221 tctgataatc cccaaatcgc tgttgcagtg gtctttcctc ataataccaa tctaacaaat
    20281 ggtgtaggac cttccattgc gcgtgacatt atcaatctgt atcaaaaata ccatccaatg
    20341 aactagaaag gaaattatgc tttatccaac acctattgcc aagttgattg acagttattc
    20401 taagttacca ggtatcggga ttaagacggc tacgcgtctg gccttttata cgattgggat
    20461 gtctgctgat gatgtcaatg aatttgcaaa aaatctcctt tctgctaaga gagaattgac
    20521 atattgttct atttgtggac gtttgacaga cgacgatcct tgttctatct gtactgatcc
    20581 gactcgtgac cagacaacaa ttttagttct tgaggatagt agagatgtgg cagccatgga
    20641 aaatatccaa gaataccatg gactctatca tgtccttcat ggcctcattt ctcctatgaa
    20701 tggtatcagt ccggacgata tcaatctcaa gagccttatg actcgtctta tggatagtga
    20761 agtttcagaa gtgattgtgg cgactaatgc tacagcggat ggtgaagcga cttccatgta
    20821 tctttcacgt ttgctcaagc cggctggtat caaggttacg cgtctagcac gaggtctcgc
    20881 tgtgggagcg gacattgagt atgcggacga agtgacactc ttacgagcca ttgaaaatcg
    20941 gacagagttg taagtgtagg caaatttacg aactcccttc atttataaaa aatcaaagag
    21001 gctgaaaatc gttcctatcg gcctcttttt gtatagtgtg atgagtagga tcaggttcaa
    21061 gttttaaaaa accaagcaaa tatgatatac taaagagcga gtattctagt agaattagga
    21121 caaataatat gaaacaaacg attattcttt tatatggtgg acggagtgcg gaacgcgaag
    21181 tctctgtcct ttcagctgag agtgtcatgc gtgcggtcaa ttacgaccgt ttcacagtca
    21241 agactttctt tatcagtcag tcaggtgact ttatcaaaac acaggaattt agtcatgctc
    21301 cggggcaaga agaccgtctc atgaccaatg aaaccattga ttgggataag aaagttgcac
    21361 caagtgctat ctacgaagaa ggtgcagtgg tctttccagt ccttcacggg ccaatgggag
    21421 aagatggctc tgttcaagga ttcttggaag ttttgaaaat gccttacgtt ggttgcaaca
    21481 ttttgtcatc aagtcttgcc atggataaaa tcacgactaa gcgtgttctg gaatctgctg
    21541 gtattgccca agttccttat gtggctatcg ttgaaggcga tgatgtgact gctaaaatcg
    21601 ctgaagtgga agaaaaattg gcttatccag tcttcactaa gccgtcaaac atggggtcta
    21661 gtgtcggtat ttctaagtct gaaaaccaag aagaactccg tccagcctta gaacttgcct
    21721 tccgatatga tagccgtgtc ttggttgagc aaggagtgaa tgcccgtgaa attgaggttg
    21781 gcctcttggg taactacgat gtcaagagca cgctaccagg agaagttgtc aaggatgttg
    21841 ccttttatga ctacgatgcc aagtatattg ataacaagat tactatggat attcctgcca
    21901 aaatcagtga tgatgtggtg gctgtcatgc gtcaaaatgc agaaacagcc ttccgtgcca
    21961 ttggtggcct tggtctatct cgttgcgatt tcttctatac agataaggga gagatttttc
    22021 tcaacgagct caataccatg ccaggtttca cccagtggtc tatgtaccca ctactttggg
    22081 acaatatggg gatcagctac ccagaactaa tcgagcgttt ggttgacctt gccaaggaaa
    22141 gttttgacaa gcgcgaagcg catttgatat aaaatgaaag agagggtaga agccagaacc
    22201 atcactgcaa ggtgactaga gttctcggac ttcagccctt tttaaaggag tagaaatgaa
    22261 attaacaatc catgaaattg cccaagttgt tggagtcaaa aatgatatca gtatctttga
    22321 ggacacccag ttagaaaaag ctgagtttga tagtcgtttg attggaactg gagatttatt
    22381 tgtgccactt aaaggtgcgc gtgatggcca tgactttatt gaaacagcct ttgaaaatgg
    22441 tgcagcagta accttgtctg agaaagaggt ctcaaatcat ccttacattc tagtagatga
    22501 tgttttgaca gcctttcaat ccctagcatc ctactatctt gaaaaaacga ctgttgatgt
    22561 ctttgctgtt acaggttcaa atggcaagac aacgactaag gatatgttgg cgcatttact
    22621 gtcaacaaga tacaagacct acaaaacaca aggaaattac aataacgaga ttggccttcc
    22681 ttacacagtt cttcatatgc ctgaagggac agaaaagttg gtcttggaga tggggcagga
    22741 tcacttggga gatattcatc tcttgtctga attggctcgt ccaaaaacag ccatcgtgac
    22801 cttggttgga gaagctcatt tggccttttt caaagaccgt tctgagattg ctaagggaaa
    22861 aatgcaaatt gcagacggaa tggcttcagg ttccttgctt ttagcgccgg ctgaccctat
    22921 cgtagaggac tatttaccaa ctgataaaaa ggtggttcgt tttgggcaag gggcagagct
    22981 ggaaattact gacttggttg agcgcaaaga tagtctaacc ttcaaggcca atttcttaga
    23041 gcaagccctt gatttgccag taactggcaa gtacaatgcg acaaatgcta tgattgcatc
    23101 ctatgttgcc ttgcaagaag gagtttcaga ggagcaaatt cgtttggcct tccaagatct
    23161 tgaattgacg cgtaaccgta ccgaatggaa gaaagcagcc aatggagcag atatcctgtc
    23221 tgatgtatac aatgccaatc caactgctat gaagttgatt ttagagactt tctctgccat
    23281 tccagccaat gaaggtggca agaaaattgc ggttttagcg gacatgaagg aactgggtaa
    23341 ccagtcagtt caactccata atcagatgat tttgagcctt tctccagatg tgcttgatac
    23401 cgttattttc tatggagaag atattgctga attagcccaa ttggctagtc aaatgttccc
    23461 aataggccac gtttactact tcaagaaaac agaagaccaa gaccaatttg aagacctagt
    23521 caagcaggtc aaagaaagcc ttggagccta tgaccaaatc ttgctaaaag gttctaactc
    23581 tatgaatcta gccaagttgg tagaaagttt agaaaatgaa gacaagtgat tttgtcaagt
    23641 atttgcaaag aatgattgcc attacagata ctggcttaac ctttacaaaa gatccgtttg
    23701 accgtgagcg ctacgaagac ttgcgagacc ttttatctga aatgttgaat cagggatcag
    23761 accttgattc cgaagaagtg gcagaagtct tgaagccaac ttctgcttat gcgactccgt
    23821 taatggacgt ccgtgcttgg attgttgagg acgaaaagat ttgtctggtt aggggacaag
    23881 gagaggatag ttgggctttg ccaggtggct ttggtgaggt tggctattct ccaacagaaa
    23941 atattctcaa ggaaattgaa gaagaaaccg gttttaaagc caaagttgaa agactgctag
    24001 ctgtttttga taccaatcgt ttccaactac agagcaaaca gtatacaaag tttgtttttg
    24061 gatgtaagct tcttgatgga caattccaag aaaatcaaga aattgctgac cttcaatttt
    24121 ttgccattga ccaactgccg aacttatctg aaaaacgcat taccaaggag caaatagagc
    24181 ttctttggca ggtttatcaa ggtcataggg ggcaatatct tgactaagaa gatgattatc
    24241 gtatttctaa atccattttt aacaactagc atggtataat aatatgcagg aaaattttga
    24301 attatgagga agactagatg aatttatggg atattttctt tacgactcag gcaaccgagc
    24361 cgcccaaatt tgaccttttt tggtatgtta gcctatttac gctcttagcc ttaacttttt
    24421 atacagccca tcgctatcgt gaaaagaagg tttaccaacg atttttccaa atcttgcaga
    24481 ctgttcagtt aatccttctt tatggttggt actgggttaa tcatatgcca ctgtcagaaa
    24541 gcctaccctt ttaccattgc cgtatggcta tgtttgtggt actcttgctt cctggtcagt
    24601 ccaaatataa acaatacttt gcattattgg gaacatttgg gacattagca gcctttgttt
    24661 atccagtgcc agatgcttac ccttttccac atattaccat tttatccttt atctttggtc
    24721 atttagcact cttggggaac tctctagttt atctattgag acagtataat gcgcgattgc
    24781 tggatgtgaa gggaattttt ctcatgacct ttgccctaaa tgccttgatt tttgtggtca
    24841 atttggtgac aggtggcgat tacggatttt tgacaaaacc gccattggtt ggggatcacg
    24901 gtctagtagc taattattta cttgtttcaa ttgtgctggt agctactatc agtttgacta
    24961 agaaaatctt agaattcttt ttagctcaag aagcagaaaa aatgattgca aaggaagctt
    25021 aacacagagc tttctttttt gctcttagag agtttttaca agcagcttat aaaataagaa
    25081 tttctgaata gacaaactca aaaaatggct gggaaattta ggaaaaaagc aagcacgatt
    25141 aaattttttg tgttataata ttttgtgaat agctatgcct atgtttagct atggaataat
    25201 acgaagtgcg aaacttggaa gatagagagg aagcgatgta atggctagag aaggcttttt
    25261 tacaggtcta gatattggaa caagctctgt caaggtgctt gtggccgagc agagaaatgg
    25321 tgaattaaat gtaattggcg tgagtaatgc caaaagtaaa ggtgtaaagg atggaattat
    25381 tgttgatatt gatgcagcag caactgctat caagtcagcc atttcccaag cggaagaaaa
    25441 ggcaggcatt tcgattaaat cagtgaatgt cggcttgcct ggtaatcttt tgcaggtaga
    25501 accaactcag gggatgattc cagtaacatc tgatactaag gaaattacgg atcaagatgt
    25561 tgaaaatgtt gtcaaatcag ctttgacaaa gagtatgaca cctgaccgtg aagtcattac
    25621 ctttattcct gaagaattta ttgtggatgg tttccaaggg attcgtgacc cacgtggcat
    25681 gatgggggtt cgccttgaaa tgcgtggttt gctttataca ggacctcgta ctatcttgca
    25741 caatttgcgt aagacggttg agcgtgcagg tgttcaggtt gaaaatgtta tcatttcacc
    25801 actagcaatg gttcagtctg ttttgaacga aggggaacgt gaatttggtg ctacagtgat
    25861 tgatatgggg gcaggtcaaa cgactgtcgc tacaatccgt aatcaagaac tccagttcac
    25921 acatattctc caagaaggtg gagattatgt aactaaagat atctccaagg ttttgaaaac
    25981 ctctcgcaaa ttagcggaag gcttgaaact gaattacggg gaagcctatc cgcctcttgc
    26041 aagcaaagaa accttccaag tagaagttat tggagaagta gaagcagtcg aagtgacgga
    26101 agcctacttg tcagaaatta tttctgcacg aatcaagcac atccttgaac aaatcaagca
    26161 agaattagat agaaggcgtc tattggacct ccctggtggt attgtcttaa tcggtgggaa
    26221 tgccatttta ccaggtatgg ttgagcttgc tcaggaagtc tttggcgtcc gtgtcaagct
    26281 ttatgttcca aatcaagttg gtatccgtaa tccagccttt gcgcatgtga ttagtttatc
    26341 agaatttgcg ggtcaattaa cagaagttaa tcttttggct cagggagcga taaaaggtga
    26401 gaatgactta agtcatcagc caattagttt tggtgggatg ctgcaaaaaa cagctcagtt
    26461 tgtacaatca acgcctgttc aaccagctcc tgctccagaa gtagagccgg tggcgcctac
    26521 agaaccaatg gcggatttcc aacaagcttc acaaaataaa ccgaaattag cagatcgttt
    26581 ccgtggcttg atcggaagca tgtttgacga ataaagagga aaaataaatt atgacatttt
    26641 catttgatac agctgctgct caaggggcag tgattaaagt aattggtgtc ggtggaggtg
    26701 gtggcaatgc catcaaccgt atggtcgacg aaggtgttac aggcgtagaa tttatcgcag
    26761 caaacacaga tgtacaagca ttgagtagta caaaagctga gactgttatt cagttgggac
    26821 ctaaattgac tcgtggtttg ggtgcaggag gtcaacctga ggttggtcgt aaagccgctg
    26881 aagaaagcga agaaacactg acggaagcta ttagtggtgc cgatatggtc ttcatcactg
    26941 ctggtatggg aggaggctct ggaactggag ctgctcctgt tattgctcgt atcgccaaag
    27001 atttaggtgc gcttacagtt ggtgttgtaa cacgtccctt tggttttgaa ggaagtaagc
    27061 gtggacaatt tgctgtagaa ggaatcaatc aacttcgtga gcatgtagac actctattga
    27121 ttatctcaaa caacaatttg cttgaaattg ttgataagaa aacaccgctt ttggaggctc
    27181 ttagcgaagc ggataacgtt cttcgtcaag gtgttcaagg gattaccgat ttgattacca
    27241 atccaggatt gattaacctt gactttgccg atgtgaaaac ggtaatggca aacaaaggga
    27301 atgctcttat gggtattggt atcggtagtg gagaagaacg tgtggtagaa gcggcacgta
    27361 aggcaatcta ttcaccactt cttgaaacaa ctattgacgg tgctgaggat gttatcgtca
    27421 acgttactgg tggtcttgac ttaaccttga ttgaggcaga agaggcttca caaattgtga
    27481 accaggcagc aggtcaagga gtgaacatct ggctcggtac ttcaattgat gaaagtatgc
    27541 gtgatgaaat tcgtgtaaca gttgtcgcaa cgggtgttcg tcaagaccgc gtagaaaagg
    27601 ttgtggctcc acaagctaga actgctacta actaccgtga gacagtgaaa ccagctcatt
    27661 cacatggctt tgatcgtcat tttgatatgg cagaaacagt tgaattgcca aaacaaaatc
    27721 cacgtcgttt ggaaccaact caggcatctg cttttggtga ttgggatctt cgccgtgaat
    27781 cgattgttcg tacaacagat tcagtcgttt ctccagtcga gcgctttgaa gccccaattt
    27841 cacaagatga agatgaattg gatacacctc catttttcaa aaatcgttaa gtaaatgaat
    27901 gtaaaagaaa atacagaact tgtttttcga gaagttgcag aggctagtct gagtgctcat
    27961 cgagagagtg gttcggtctc tgtcattgca gttaccaagt atgtagatgt accgacagcg
    28021 gaagccttgc ttccgctagg tgttcatcat atcggtgaaa atcgtgtaga taagtttctg
    28081 gaaaaatatg aagctttaaa agatcgagat gtgacttggc atttgattgg taccttgcaa
    28141 agacgtaagg tgaaagatat cattcaatac gttgattatt tccatgcatt ggactcagta
    28201 aagctagcag gggaaattca aaaaagaagt gaccgagtca tcaagtgttt ccttcaagta
    28261 aatatttcta aagaagaaag caaacacggt ttttcgagag aggaactgct ggaaatcttg
    28321 ccagagttag ccagactaga taagattgaa tatgttggtt taatgacgat ggcacctttt
    28381 gaggctagca gtgagcagtt gaaagagatt ttcaaggcgg cccaagattt acaaagagaa
    28441 attcaagaga aacaaattcc aaatatgcct atgaccgagt taagtatggg aatgagtcgt
    28501 gattataaag aagcgattca attcggttcc acttttgttc gtataggtac atcatttttt
    28561 aagtaggaga gaaccatgtc tttaaaagat agattcgata gatttataga ttattttacg
    28621 gaggatgagg attcaagtct cccttatgaa aaaagagatg agcctgtgtt tacttcagta
    28681 aattcttcac aggaaccggc tctcccaatg aatcaacctt cacagtcggc tggtacaaaa
    28741 gagaacaata tcaccagact tcatgcaaga caacaggaat tggcaaatca gagtcagcgt
    28801 gcaacggata aggtcattat agatgttcgt tatcctagaa aatatgagga tgcaacagaa
    28861 attgttgatt tattggcagg aaacgaaagt atcttgattg attttcagta tatgacagag
    28921 gtgcaggctc gtcgttgttt ggactatttg gatggagctt gtcatgtttt agctggaaat
    28981 ttgaaaaagg tagcttctac catgtatttg ttgacaccag tgaacgttat tgtaaatgtt
    29041 gaagatatcc gtttaccaga tgaagatcaa cagggtgagt tcggttttga tatgaagcga
    29101 aatagagtac gataatgatt tttttaattc gtatgattta taatgcagtg gatatttact
    29161 ccctgatttt ggtagccttc gctgtcatgt cttggtttcc aggtgcctac gaatccagtt
    29221 taggtcgttg gattgtagcg ttggtgaaac cagtgcttgc tcccttgcaa cgcctgcctt
    29281 tacagatagc gggtcttgat ttatctgttt gggtcgcgat tgttttggtt cgatttttag
    29341 gagaaaacct agtgcgtttt ctggcgatga taggatgaat aaagggattt atcagcattt
    29401 ctccatagaa gatcgtccat ttcttgacaa gggaatggaa tggataaaga aggtagaaga
    29461 tagctatgct ccttttttaa ctccttttat caatcctcat caggagaagc tattaaagat
    29521 tttggccaaa acctatggta ttgcttgtag cagtagtggg gaattcgtct cgagtgagta
    29581 tgttcgagtt ttattatacc cagattattt ccaaccagag ttttcagatt ttgaaatatc
    29641 tctccaggaa attgtgtatt ccaataaatt tgaacattta acgcatgcta agattttagg
    29701 gacagtcatc aatcaattag ggattgaacg gaaacttttt ggagatatcc tagtagatga
    29761 agaacgggcg cagattatga ttaatcagca gtttcttctt ctctttcaag atggactaaa
    29821 gaaaattggt cgtatacctg tttcgctgga ggaacgtcct ttcaccgaga aaatagataa
    29881 gctagaacag tatcgagaac tgaatttatc tgtgtctagt tttcgattag atgttctttt
    29941 atcaaatgtt ttgaaactat ctaggaatca agcaaaccag ttgattgaaa agaaacttgt
    30001 ccaagtaaat tatcatgtgg tagacaaatc agattacact gttcaagttg gagacttgat
    30061 tagtgtgaga aaatttggtc gcttgagatt atttcaagat aagggacaaa cgaaaaaaga
    30121 gaagaaaaaa ataaccgtcc agttattatt aagtaagtga ggaatagaat gccaattaca
    30181 tcattagaaa taaaggacaa gacctttgga actcgattca gaggttttga tccagaagaa
    30241 gtcgatgaat ttttagatat tgtggttcgt gattacgaag atcttgtgcg tgcgaatcat
    30301 gataaaaatt tgcgtattaa gagtttagaa gagcgtttgt cttactttga tgaaataaaa
    30361 gattcattga gccagtctgt attgattgcc caggatacag ctgagagagt gaaacaggcg
    30421 gcgcatgaac gttcaaacaa tatcattcat caagcagagc aagatgcgca acgcttgttg
    30481 gaagaagcta aatataaggc aaacgagatt cttcgtcaag caactgataa tgctaagaaa
    30541 gtcgctgttg aaacagaaga attgaagaac aagagccgtg tcttccacca acgtctcaaa
    30601 tctacaattg agagtcagtt ggctattgtt gaatcttcag attgggaaga tattctccgt
    30661 ccaacagcta cttatcttca aactagtgat gaagccttta aagaagtggt tagcgaagta
    30721 cttggagaac cgattccagc tccaattgaa gaagaaccaa ttgatatgac acgtcagttc
    30781 tcccaagcag aaatggaaga attacaagct cgtattgagg tagccgataa agaattgtct
    30841 gaatttgaag ctcagattaa acaggaagtg gaaactccaa ctcctgtagt gagtcctcaa
    30901 gttgaagaag agcctctgct catccagttg gcccaatgta tgaagaacca gaagtagctc
    30961 cagtgcatcc gacaggtcca acaccagcta cagaaactgt tgattcagca ccgggatttg
    31021 aagcaccgca agaatctgtt acaattttat aagaaatatt ctgagaacaa tatcttatcc
    31081 ttatattccc agcgagcagg agatggtgtg agtcctgcat tccctatcga taagattatc
    31141 ctctcaaaaa ctcaagtctg aatctagtaa gatttgacgt tccccacgtt acgggataag
    31201 agggagaaag actaaaactt tttccgaata aaggtggtac cacgattttc gtcctttttg
    31261 gaagtcgtgg tttttaattt gttattattt ataaaggaga taccatgaaa ctcaaagaca
    31321 cccttaatct tgggaaaact gaattcccaa tgcgtgcagg ccttcctacc aaagagccag
    31381 tttggcaaaa ggaatgggaa gatgcaaaac tttatcaacg tcgtcaagaa ttgaaccaag
    31441 gaaaacctca tttcaccttg catgatggcc ctccatacgc taacggaaat atccacgttg
    31501 gacatgctat gaacaagatt tcaaaagata tcattgttcg ttctaagtct atgtcaggat
    31561 tttacgcacc atttattcct ggttgggata ctcatggtct gccaatcgag caagtattgt
    31621 caaaacaagg tgtcaaacgt aaagaaatgg acttggttga gtacttgaaa ctttgccgtg
    31681 agtacgctct ttctcaagta gataaacaac gtgaagattt taaacgtttg ggtgtttctg
    31741 gtgactggga aaatccatat gtgaccttga ctcctgacta tgaagcagct caaattcgtg
    31801 tatttggtga gatggctaat aagggttata tctaccgtgg tgccaagcca gtttactggt
    31861 catggtcatc tgagtcagcc cttgctgaag cagagattga ataccatgac ttggtttcaa
    31921 cttcccttta ctatgccaac aaggtaaaag atggcaaagg agttctagat acagatactt
    31981 atatcgttgt ctggacaacg actccattta ccatcacagc ttctcgtggt ttgacggttg
    32041 gtgcagatat tgattacgtt ttggttcaac ctgctggtga agctcgtaag tttgtcgttg
    32101 ctgctgaatt attgactagc ttgtctgaga aatttggctg ggctgatgtt caagttttgg
    32161 aaacttaccg tggccaagaa ctcaaccaca tcgtaacaga acacccatgg gatacagctg
    32221 tagaagagtt ggtaattctt ggtgaccacg ttacgactga ctctggtaca ggtattgtcc
    32281 atacagcccc tggttttggt gaggacgatt acaatgttgg tattgctaat aatcttgaag
    32341 tcgcagtgac tgttgatgaa cgtggtatca tgatgaagaa tgctggtcct gaatttgaag
    32401 gtcaattcta tgaaaaggta gttccaactg ttattgaaaa acttggtaac ctccttcttg
    32461 cccaagaaga aatctctcac tcatatccat ttgactggcg tactaagaaa ccaatcatct
    32521 ggcgtgcagt tccacaatgg tttgcctcag tttctaaatt ccgtcaagaa atcttggacg
    32581 aaattgaaaa agtgaaattc cactcagaat ggggtaaagt ccgtctttac aatatgatcc
    32641 gtgaccgtgg tgactgggtt atctctcgtc aacgtgcttg gggtgttcca cttcctatct
    32701 tctacgctga agatggtaca gctatcatgg tagctgaaac tattgaacac gtagctcaac
    32761 tttttgaaga acatggttca agcatttggt gggaacgtga tgccaaagac ctcttgccag
    32821 aaggatttac tcatccaggt tcaccaaacg gcgagttcaa aaaagaaact gatatcatgg
    32881 acgtttggtt tgactcaggt tcatcatgga atggagtggt ggtaaaccgt cctgaattga
    32941 cttacccagc cgacctttac ctagaaggtt ctgaccaata ccgtggttgg tttaactcat
    33001 cacttatcac atctgttgcc aaccatggcg tagcacctta caaacaaatc ttgtcacaag
    33061 gttttgccct tgatggtaaa ggtgagaaga tgtctaaatc tcttggaaat actattgctc
    33121 caagcgatgt tgaaaaacaa ttcggtgctg aaatcttgcg tctctgggta acaagtgttg
    33181 actcaagcaa tgacgtgcgt atctctatgg atatcttgag ccaagtttct gaaacttacc
    33241 gtaagattcg taacactctt cgtttcttga ttgccaatac atctgacttt aacccagctc
    33301 aagatacagt cgcttacgat gagcttcgtt cagttgataa gtacatgacg attcgcttta
    33361 accagcttgt caagaccatt cgtgatgcct atgcagactt tgaattcttg acgatctaca
    33421 aggccttggt gaactttatc aacgttgact tgtcagcctt ctaccttgat tttgccaaag
    33481 atgttgttta cattgaaggt gccaaatcac tggaacgccg tcaaatgcag actgtcttct
    33541 atgacattct tgtcaaaatc accaaactct tgacaccaat ccttcctcac actgcggaag
    33601 aaatttggtc atatcttgag tttgaagccg aagacttcgt ccaattgtca gaattaccag
    33661 aggctcaaac ttctgctaac caagaagaaa tcttggatac atgggcagcc ttcatggact
    33721 tccgtggaca agcacaaaaa gccttggaag aagctcgtaa tgcaaaagtt atcggtaaat
    33781 cacttgaagc acacttgaca gtttatccaa atgaagtggt gaaaactcta ctcgaagcag
    33841 taaacagcaa tgtagctcaa cttttgatcg tgtctgagtt gaccatcgca gaagaaccaa
    33901 ctccggaagc tgcccttagc ttcgaagatg tagccttcac agttgaacgt gctgctggtg
    33961 aagtatgtga ccgttgccgt cgtatcgacc caacaacagc agaacgcagc taccaggcag
    34021 ttatctgtga ccactgtgca agcatcgtag aagaaaattt tgcggatgca gtcgcagaag
    34081 gatttgaaga gaaataagat tgaaaagtct aggcaaaatt caatttgaga agaaaagaca
    34141 actaatttta tagtctatta aacgcattgt atcacgtttt tgaacacctg atatgatgcg
    34201 tttttattta ttttgaaaat ttgtgaggtg tgacttttta tactcaacaa gaatcaaaga
    34261 gaaacttagc aagctaacag tagtaagata aaataggaat ttgatattag ggataagatt
    34321 ggta
//
LOCUS       DAVHIZ010000019        34235 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.019, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000019 DAVHIZ010000000
VERSION     DAVHIZ010000019.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 34235)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 34235)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..34235
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.019"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(227..1861)
                     /locus_tag="VVO18_000937"
     CDS             complement(227..1861)
                     /locus_tag="VVO18_000937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586115.1"
                     /translation="MRLKVIKKLVDINILYSSQEANLANLRKKQAKNPGKKVNVSARV
                     LSSYIFSSLLMLICFSNIAIHFPFEEIPIYFSSMVAILLVIAFSTSLTAFYNVFYESK
                     DLVSYRPYAFKESEIIIAKGLSVLLPALTGIVPILAYFLVLYIRLAPSLWLGLPLMLL
                     SLTLLFVSVALVMVVAVHFLAQTTVFRKYQSIFSNVMIGIGVLIPLIFVFFLQSTFGS
                     IVDKVRDIPFLLYPLHIFYKIAVEPFSIEAILGLLAWIALTVFLLYLTKKKVLPRFYD
                     VILLNSEEKVKKERRSKERISTTKKGFFRMVLRYHLTLLGQGTGVITVLFTSAFLPYL
                     MMISLISKIRDSQIVPDIHPPYWLPLFFVGVFIAVVNNNITSLHSIALSLERENLDFL
                     KSLPFDFARYVKVKFWIIFAVQSFLPILTLLGLSLYLGLSILSMIYLLVVWIIASVIL
                     SCHHYFKDVKNLSTNWSSITDLVNRSNGIVAIVLLFIYSAILMALVIGSIFLVQSLSP
                     ILAINLGVGALIVLLALAIFGYHYYLSRILAEIEKR"
     gene            complement(1842..2591)
                     /locus_tag="VVO18_000938"
     CDS             complement(1842..2591)
                     /locus_tag="VVO18_000938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586116.1"
                     /translation="MIEFQNVSKLYGDKEALSNLNLQIENGEIMGLIGHNGAGKSTTI
                     KSLVSIISPSSGRILVDGQELSENRLAIKRKIGYVADSPDLFLRLTANEFWELIASSY
                     DLSRSDLEASLARLLNVFDFAENRYQVIETLSHGMRQKVFVIGALLSDPDIWVLDEPL
                     TGLDPQAAFDLKQMMKEHAQKGKTVLFSTHVLEVAEQVCDRIAILKKGHLIYCGKVED
                     LRKDHPDQSLESIYLSLAGRKEEVADASQGH"
     gene            2770..4224
                     /locus_tag="VVO18_000939"
     CDS             2770..4224
                     /locus_tag="VVO18_000939"
                     /EC_number="3.2.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-amylase"
                     /protein_id="HEU5586117.1"
                     /translation="MQNQTLMQYFEWYLPHDGQHWTRLAENAPHLAHLGISHVWMPPA
                     FKATNEKDVGYGVYDLFDLGEFNQKGTVRTKYGFKEDYLQAIQALKAQGIQPMADVVL
                     NHKAAADHREAFQVIEVDPVDRTVELGEPFTINGWTSFTFDGRQDTYNGFHWHWYHFT
                     GTDYDAKRSKSGIYLIQGDNKGWANEELVDNENGNYDYLMYADLDFKHPEVIQNIYDW
                     ADWFMETTGVAGFRLDAVKHIDSFFMRNFIRDMKEKYGDDFYVFGEFWNPDKEANLDY
                     LEKTEEHFDLVDVRLHQNLFEASQAGANYDLRGIFTDSLVELKPDKAVTFVDNHDTQR
                     GQALESTVEEWFKPAAYALILLRQDGLPCVFYGDYYGISGQYAQEDFKEILDRLLAIR
                     KDLAYGEQNDYFDHANCIGWVRSGAENQSPIAVLISNDQENSKSMFVGQEWTNQTFVD
                     LLGNHQGQVTIDEEGYGQFPVSARSVSVWAVNTI"
     gene            complement(4314..6932)
                     /gene="alaS"
                     /locus_tag="VVO18_000940"
     CDS             complement(4314..6932)
                     /gene="alaS"
                     /locus_tag="VVO18_000940"
                     /EC_number="6.1.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012130635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine--tRNA ligase"
                     /protein_id="HEU5586118.1"
                     /translation="MKQLSSAQVRQMWLDFWATKGHSVEPSVSLVPVNDPTLLWINSG
                     VATLKKYFDGTIIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRD
                     EAITWAYELLTSPEWFDFPAEKLYMTYYPDDKDSYNRWIEVGVDPSHLIPIEDNFWEI
                     GAGPSGPDTEIFFDRGEAFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRS
                     EYKELPHKNIDTGAGLERLVAVTQGAKTNFETDLFMPIIREVEKLSGKVYDQDGDNMS
                     FKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRASMHGQKLGINEPFLYKLVPTV
                     GNIMESYYPEVLEKRDFIEKIVKSEEESFARTLHSGQHFAQGIVADLKEKGQSVIAGQ
                     DVFKLYDTYGFPVELTEEIAEEAGMTVDREGFEAAMKEQQERARASAVKGGSMGMQNE
                     TLQNITVESVFNHNASQLSSKLVAIVADNAEVEAVSEGTTSLIFAETPFYAEMGGQVA
                     DHGQILDESGKVVATVTNVQKAPNGQALHTVEVLAPLALNQEYTLAIDSNRRHRVMKN
                     HTATHLLHAALHNILGNHATQAGSLNEVEFLRFDFTHFQAVTAEELRAIEQQVNEKIW
                     EALEVKTVETDIDTAKEMGAMALFGEKYGKEVRVVTIGDYSIELCGGTHVGNTSEIGL
                     FKIVKEEGIGSGTRRILAVTGKEAFEAYREQEDALKAIAATLKAPQVKEVPHKVEGLQ
                     EQLRQLQKENAELKEKAAAAAAGDIFKDVKEVNGHRYIASQVSVSDAGALRTFADNWK
                     QKDYSDLLVLVAAIGDKVNVLVASKTKDLHAGNLVKELAPIIDGRGGGKPDMAMAGGS
                     NQAKIQELLDAVAGKL"
     gene            complement(6954..7439)
                     /locus_tag="VVO18_000941"
     CDS             complement(6954..7439)
                     /locus_tag="VVO18_000941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LURP-one-related family protein"
                     /protein_id="HEU5586119.1"
                     /translation="MKTFLVKQKFRLGGERFAIKDDRGEIAYQVEGSFFKIPKTFTIY
                     DAAGEQVSEISKEILTLLPRFEIQLRDGSSFVIRKKLTFWRDKYEFDNLGLRIEGNIW
                     DLNFKLLDDRDQLIAEIKKELFHLTSTYTVTVLEDAYADLVISLCVAIDYVEMLESQS
                     H"
     gene            complement(7714..7953)
                     /locus_tag="VVO18_000942"
     CDS             complement(7714..7953)
                     /locus_tag="VVO18_000942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000784186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586120.1"
                     /translation="MKMSTFFKKSFWPTFMIVNQTVILSHLKDGLDRQYLTTESIYWV
                     IGTFIFGNILVAVFSNMKIWDKKKNGSKKKYILKK"
     gene            complement(8198..9268)
                     /locus_tag="VVO18_000943"
     CDS             complement(8198..9268)
                     /locus_tag="VVO18_000943"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5586121.1"
                     /translation="MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGD
                     YIDPELLTQFTEETGIQVQYETFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDL
                     LVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDL
                     WKLEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDPQQLEETVDKLYKLTPNIKAIVAD
                     EMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQDS
                     AYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYE
                     KFDHKWTGKYSDLFLQFKMYRK"
     gene            complement(9265..10038)
                     /locus_tag="VVO18_000944"
     CDS             complement(9265..10038)
                     /locus_tag="VVO18_000944"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398754.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586122.1"
                     /translation="MKKFANLYLGLVFLVLYLPIFYLIGYAFNAGDDMNSFTGFSWTH
                     FETMFGDGRLMLILAQTFFLAFLSALIATIIGTFGAIYIYQSRKKYQEAFLSLNNILM
                     VAPDVMIGASFLILFTQLKFSLGFLTVLSSHVAFSIPIVVLMVLPRLKEMNGDMIHAA
                     YDLGASQFQMFKEIMLPYLTPSIITGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYS
                     RARKGISLEINALSALVFLFSIILVVGYYFISREKEEQA"
     gene            complement(10035..10841)
                     /locus_tag="VVO18_000945"
     CDS             complement(10035..10841)
                     /locus_tag="VVO18_000945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398755.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586123.1"
                     /translation="MKKTSSKLFVVPYMLWIALFVLAPLVLIFGQSFFNIEGQFSLEN
                     YKSYFASQNLTYLKMSFNSVLYAGIVTFVTLLISYPTALFLTRLKHRQLWLMLIILPT
                     WINLLLKAYAFIGIFGQNGSINQFLEFIGIGSQQLLFTDFSFIFVASYIELPFMILPI
                     FNVLDDMDNNLINASYDLGATKWETFRHVIFPLSMNGVRSGVQSVFIPSLSLFMLTRL
                     IGGNRVITLGTAIEQNFLTNDNYGMGSTIGVILILTMFITMWVTKERRER"
     gene            complement(10822..11979)
                     /locus_tag="VVO18_000946"
     CDS             complement(10822..11979)
                     /locus_tag="VVO18_000946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018372333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586124.1"
                     /translation="MKKPIIEFKNVSKVFEDSNTKVLKDINFELEEGKFYTLLGASGS
                     GKSTILNIIAGLLDATTGDIMLDGVRINDIPTNKRDVHTVFQSYALFPHMNVFENVAF
                     PLRLRKIDKKEIEQRVAEVLKMVQLEGYEKRSIRKLSGGQRQRVAIARAIINQPRVVL
                     LDEPLSALDLKLRTDMQYELRELQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQ
                     SGTPVDIYDEPINHFVATFIGESNILPGTMIEDYLVEFNGKRFEAVDGGMKPNEPVEV
                     VIRPEDLRITLPEEGKLQVKVDTQLFRGVHYEIIAYDELGNEWMIHSTRKAIVGEEIG
                     LDFESEDIHIMRLNETEEEFDARIEEYVEIEEQEAGLINAIEEERDEENKL"
     gene            complement(12038..12988)
                     /gene="murB"
                     /locus_tag="VVO18_000947"
     CDS             complement(12038..12988)
                     /gene="murB"
                     /locus_tag="VVO18_000947"
                     /EC_number="1.3.1.98"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000116191.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramate dehydrogenase"
                     /protein_id="HEU5586125.1"
                     /translation="MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRF
                     ELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGA
                     NLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEI
                     ETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEY
                     PSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQ
                     SVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR"
     gene            complement(13100..13852)
                     /locus_tag="VVO18_000948"
     CDS             complement(13100..13852)
                     /locus_tag="VVO18_000948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000152219.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YhfC family intramembrane metalloprotease"
                     /protein_id="HEU5586126.1"
                     /translation="MTIHIIITMLLLLAFLIGSIWFAKKKYQINLAVLGLGAVAFFVS
                     SQILEKLVHILILHPQKDGSIALLQDHPLVYIIYGLAMAAFFEETARLVFFKWLEKKI
                     SLEKADALAYGLGHGGLELIFLGLTSLLNLYIVLSAVQTQNPQVMQLLSENMLKTIQS
                     LSVWQIYLLGFERILALGFQLLLTVWVYQAVRQKKWIYLLTAYGLHAFFDLAPSLFQV
                     GWLTNPVLVEVILALELVLIAYGTKEIFCKKS"
     gene            complement(13862..14593)
                     /gene="budA"
                     /locus_tag="VVO18_000949"
     CDS             complement(13862..14593)
                     /gene="budA"
                     /locus_tag="VVO18_000949"
                     /EC_number="4.1.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000360290.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acetolactate decarboxylase"
                     /protein_id="HEU5586127.1"
                     /translation="MDKNVQEPVKLFQYNTLGALMAGLYGGTMTVGELLEHGDLGLGT
                     LDSIDGELIVLDGKAYQAKGTGEQPEIVEVSPDALIPYAAVVPHQAEVIFRQRFEMTD
                     KELEERIESYYDGENLFRSIKIRGEFSHMHVRMIPKSTPDTKFADVATHQPEYSRDNV
                     VGTIVGFWTPEIFHGVSVAGYHLHFISDDLTFGGHVMDFVIKEGIIEVGAVDQLDQRF
                     PVQDRQYLFAKFNVDEMKKDIEKAE"
     gene            14735..16006
                     /locus_tag="VVO18_000950"
     CDS             14735..16006
                     /locus_tag="VVO18_000950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="HEU5586128.1"
                     /translation="MKRQSKYKEVVSYLKNGIESGRFPTGSRLPSIRQLSLDFHCSKD
                     TIQRALLELRHEQYLYAKPQSGYYVLEQGQHQDLEIEVTDEHASAYDDFRLCVNETLI
                     GRENYLFNYYDNQEGLEDLRQSIHKLLFEQALYCKANQLVLTSGTQQALFILSQISFP
                     RQAKEILVEQPTYHRMNRLLIAQGLDYQTIERGIDGIDLEELEGHFKTGKIKFFYTIP
                     RFHYPLGHSYSEQDKRSILNLAAKYDVYIVEDDYLGDLDSKKGQTFHYLDTEERVIYI
                     KSFSTSLFPALRITALILPNAIKEAFMAYKNILDYDSNLIMQKALSLYIDSQLFEKNR
                     LARLTNHESYQKQIEERITKTPCPLPHYPLHDGLLLDLRQYPKIASLKHSQLGLDFFE
                     EAYLSTCPYQFAKVSLDNLENVLNYLKAELE"
     gene            complement(16026..16841)
                     /locus_tag="VVO18_000951"
     CDS             complement(16026..16841)
                     /locus_tag="VVO18_000951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU5586129.1"
                     /translation="MKSKKWIFVLCNFLASFFLVACQSGSNGSQSAVEAIKQKGKLVV
                     ATSPDYAPFEFQSLVDGKNQVVGADIDMAQAIADELGVKLEILSMSFDNVLTSLQTGK
                     ADLAVAGISATDERKEVFDFSIPYYENKISFLVRKADVEKYKDLTSLESANIAAQKGT
                     VPESMVKEQLPKAQLTSLTNMGEAVNELQAGKIDAVHMDEPVALSYAAKNAGLAVATV
                     SLKMKDGDANAVALRKNSDDLKEVVDKVIQKLKDEGTYQSYLEKAASLTEVEE"
     gene            complement(16998..17651)
                     /gene="phoU"
                     /locus_tag="VVO18_000952"
     CDS             complement(16998..17651)
                     /gene="phoU"
                     /locus_tag="VVO18_000952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000946475.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate signaling complex protein PhoU"
                     /protein_id="HEU5586130.1"
                     /translation="MLRSQFEEDLEKLHNQFYAMGQEVLSQINRTVRAFVTHDRDLAK
                     EVIEDDAEVNEYEVKLEKKSFEMIALQQPVSQDLRTVLTVLKAVSDVERMGDHAVAIA
                     QATIRMKGEERIPAVEEEIKKMGREVKSVVEAALDLYLNGSVDDAYRVASMDEQINHY
                     FETIRDLATEEIKKNPEAIVTGRDYFQVISYLERIGDYAKNICEWVVYFETGKIVEL"
     gene            complement(17663..18421)
                     /gene="pstB"
                     /locus_tag="VVO18_000953"
     CDS             complement(17663..18421)
                     /gene="pstB"
                     /locus_tag="VVO18_000953"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU5586131.1"
                     /translation="MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGK
                     STLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTI
                     YENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVA
                     RVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTG
                     FFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG"
     gene            complement(18434..19237)
                     /gene="pstB"
                     /locus_tag="VVO18_000954"
     CDS             complement(18434..19237)
                     /gene="pstB"
                     /locus_tag="VVO18_000954"
                     /EC_number="7.3.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000852852.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter ATP-binding protein"
                     /protein_id="HEU5586132.1"
                     /translation="MSTYNWDEKHILTFPEEKVALSTKDVHVYYGKNESIKGIDMQFE
                     RNKITALIGPSGSGKSTYLRSLNRMNDTIDIAKVTGQILYRGIDVNRPEINVYEMRKH
                     IGMVFQRPNPFAKSIYRNITFAHERAGVKDKQVLDEIVETSLRQAALWDQVKDDLHKS
                     ALTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNFTIIIV
                     THNMQQAARASDYTGFFYLGDLIEYDKTATIFQNAKLQSTNDYVSGHFG"
     gene            complement(19248..20132)
                     /gene="pstA"
                     /locus_tag="VVO18_000955"
     CDS             complement(19248..20132)
                     /gene="pstA"
                     /locus_tag="VVO18_000955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009443446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease PstA"
                     /protein_id="HEU5586133.1"
                     /translation="MRAKKLDKLATAVLYTIASIIVTILASLILYILVRGLPHISWSF
                     LTGRSSAFQAGGGIGIQLYNSFFLLVITLIISVPLSMGAGIYLAEYAKKGPVTNFVRT
                     CIEILSSLPSVVVGLFGYLIFVVQFEYGFSIISGALALTVFNLPQMTRNVEDSLKHVH
                     HTQREAGLALGISRWETVVHVVIPEALPGIVTGVVLASGRIFGEAAALIYTAGQSAPA
                     LDWSNWNILSVTSPISIFRQAETLAVHIWKVNSEGTIPDGTIVSAGSAAVLLIFILIF
                     NFGARKFGSYLHKKLTAA"
     gene            complement(20122..21039)
                     /gene="pstC"
                     /locus_tag="VVO18_000956"
     CDS             complement(20122..21039)
                     /gene="pstC"
                     /locus_tag="VVO18_000956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018378778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter permease subunit PstC"
                     /protein_id="HEU5586134.1"
                     /translation="MNQEELAKKMLLPSKNSRLEKLGKGLTFACLSLIVILVAMILVF
                     VAQKGLSTFFVNGVNIFDFLLGGTWNPSSKEFGALPMILGSFIVTILSALIATPFAIG
                     AAVFMTEVSPKGAKILQPAIELLVGIPSVVYGFIGLQVVVPFVRSVFGGTGFGILSGI
                     SVLFVMILPTVTFMTTDSLRAVPRYYREASFAMGATRWQTIWRVILKAARSGIFTAVV
                     FGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSILTMGIGNTVMGTVNNNVLWSL
                     ALVLLLMSLVFNSVIKLITKERGKKNYAR"
     gene            complement(21039..21917)
                     /gene="pstS"
                     /locus_tag="VVO18_000957"
     CDS             complement(21039..21917)
                     /gene="pstS"
                     /locus_tag="VVO18_000957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746338.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate ABC transporter substrate-binding
                     protein PstS"
                     /protein_id="HEU5586135.1"
                     /translation="MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPL
                     VEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVD
                     HKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGS
                     RATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYD
                     LSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMK
                     VEKDAAGTVTVLEGRQ"
     gene            complement(22491..23795)
                     /locus_tag="VVO18_000958"
     CDS             complement(22491..23795)
                     /locus_tag="VVO18_000958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160253.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RsmF rRNA methyltransferase first C-terminal
                     domain-containing protein"
                     /protein_id="HEU5586136.1"
                     /translation="MKFPEGFVEKYKEILGDEARDFLASFEEEAVSAFRVNPLKEEQL
                     SFSDAITQTPWGHYGKVSGKSPEHATGLVYSQEPAAQMVAQVAQPSPGMKVLDLAAAP
                     GGKSTQLAAYLAGEGLLVSNEISSKRAKILVENMERFGATNVVVTNESADRLVKVFKG
                     YFDLIVLDAPCSGEGMFRKQPDAMDYWSLDYPSQCVSLQREILEDAVTMLAEGGRLVY
                     STCTWAPEENEEIVNWLLEEYDFDLLPVEHINGMVAGIDLPETARMYPHQFKGEGQFV
                     AHLQFKGNNPAPKFKASKSNLSREQVALWQEFAQNHLKVNLPGILQIFGDQLYLLPEL
                     LPDLGKLKIARNGLHLGTFKKKRFEPSFALGLALKPSQVEQSVEIGQEEFVKYAAGEI
                     VQLAESLPNGWYQVLVKGNGLGFAKVTGNVLKNYFPKGLRFK"
     gene            complement(23796..24569)
                     /locus_tag="VVO18_000959"
     CDS             complement(23796..24569)
                     /locus_tag="VVO18_000959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="inositol monophosphatase family protein"
                     /protein_id="HEU5586137.1"
                     /translation="MESKFEFAKGLVKKAGQYILDHMQEDLRVETKSSPTDLVTRLDK
                     EVQELLVGEILSRYPEDKICAEEGCLRASVQEGKVWVIDPIDGTNNFVAQQEDFAVMM
                     AYFENGQGQFGLIYDVVKGDCYHGGGEFPVCLNDRPLAPFKTKPLGDFLIAGNSGMLE
                     TNEWGLADLSRAVLGVRVYGSAAISFAKILSGHLLTYLTYLQPWDYAAASILGESLGY
                     RVVTLFGEAPDFQTRQPVMMVPLEMQEEIQSYIYERKRT"
     gene            complement(24559..24837)
                     /locus_tag="VVO18_000960"
     CDS             complement(24559..24837)
                     /locus_tag="VVO18_000960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UPF0223 family protein"
                     /protein_id="HEU5586138.1"
                     /translation="MNKQYSYPLDLSWSTEELASVLSFFNDVEAAYEGKVEAKKLLDS
                     YKGFKAVVPSKSEEKRLGREFETVSGYSLYRAVQAAKEKGEGKISLGK"
     gene            complement(24837..25238)
                     /locus_tag="VVO18_000961"
     CDS             complement(24837..25238)
                     /locus_tag="VVO18_000961"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007556665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Spx/MgsR family RNA polymerase-binding
                     regulatory protein"
                     /protein_id="HEU5586139.1"
                     /translation="MITLFLSPSCTSCRKAKAWLEKHKVPFVEHNIMTSPLTRKELQH
                     ILSLTENGTDDIISTRSKIFQKLNIDVESISVSELLHLIEQYPSLLRRPIIIDAKRMQ
                     IGFNEDEIRAFLPRSYRKQELKEARMRAGIS"
     gene            complement(25448..26065)
                     /locus_tag="VVO18_000962"
     CDS             complement(25448..26065)
                     /locus_tag="VVO18_000962"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850480.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01906 family membrane protein"
                     /protein_id="HEU5586140.1"
                     /translation="MKTKLTFWGSMLFLLSLSILLTIYLAWIFYPMEIQWLNLTNRVY
                     LKPETVQYNFHILMNYLTNPFSQVLQMPDFRSSAAGLHHFAVVKNLFHLVQLVALVTL
                     PSFYVFVNRIVKKDFLSLYRKSLLALVVLPVMIGLGGVLIGFDQFFTLFHQILFVGDD
                     TWLFDPAKDPVIMILPETFFLHAFLLFFALYENFFGYLYLKSRRK"
     gene            complement(26055..26828)
                     /locus_tag="VVO18_000963"
     CDS             complement(26055..26828)
                     /locus_tag="VVO18_000963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258500.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR01457 family HAD-type hydrolase"
                     /protein_id="HEU5586141.1"
                     /translation="MKYKGYLIDLDGTIYKGKDRIPAGETFVHELQKRDIPYLFVTNN
                     TTRTPESVKEMLAQNFNIDTPLSTVYTATLATIDYMNDLGLEKTVYVVGEAGLKEAIK
                     AAGYVEDKENPAYVVVGLDWQVDYEKFATATLAIQKGAHFIGTNPDLNIPTERGLLPG
                     TGSLITLLEVATRVKPVYIGKPNAIIMDKAVEHLGLEREELIMVGDNYLTDIRAGIDN
                     GIPTLLVTTGFTKAEEVAGLPIAPTHVVSSLAEWDFDEN"
     gene            complement(26839..27576)
                     /locus_tag="VVO18_000964"
     CDS             complement(26839..27576)
                     /locus_tag="VVO18_000964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-[acyl-carrier-protein] thioesterase"
                     /protein_id="HEU5586142.1"
                     /translation="MGLTYQMKMKIPFDMADMNGHIKLPDVILLSLQVSGMQSIELGV
                     SDKAILEDYNLVWIIAEYDIEVVRLPRFAEEITIETEALSYNRLFCYRRFTIYNEAGQ
                     ELIHMMATFVLMDRDSRKVHAVEPEIVAPYQSDFDKKLIRGPKYESLEEPISKDYHVR
                     FYDLDMNGHVNNSKYLDWIFEVMGADFLTHYIPKKINLKYVKEVRPGGVITSAVERTG
                     LESKHEITSDGVINAQAIITWQEIKKV"
     gene            complement(27581..28711)
                     /locus_tag="VVO18_000965"
     CDS             complement(27581..28711)
                     /locus_tag="VVO18_000965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxygen-independent coproporphyrinogen III
                     oxidase"
                     /protein_id="HEU5586143.1"
                     /translation="MQKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDSYLEHLLEE
                     FRSYDIEKLSTLYIGGGTPTALSAPQLEVLLNGLTKNLDLSVLEELTIEANPGDLDAD
                     KIAVLKNSAVNRVSLGVQTFDDKMLKKIGRSHLEKDIYENIDRLKLAGFDNISIDLIY
                     ALPGQTMEQVKENVAKAIGLDIPHMSLYSLILENHTVFMNRMRRGKLPLPKEELEAEM
                     FEYIIAELERAGFEHYEISNFSKPGFESRHNLMYWDNAEYYGIGAGASGYVNGVRYKN
                     HGPIRHYLSAVEEGNACITEDHLSQKEQMEEEMFLGLRKKSGVSMARFEEKFGQSFAG
                     LYGEIVRDLVQQGLMQIEGDHVRMTKRGLFLGDTVAERFILE"
     gene            complement(28795..29184)
                     /locus_tag="VVO18_000966"
     CDS             complement(28795..29184)
                     /locus_tag="VVO18_000966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU5586144.1"
                     /translation="MGKLSSILLGTVSGAALALFLTSDKGKQVCSQAQDFLDDLREDP
                     EYAKEQVCEKLTEVKEQATDFVLKTKEQVESGEITVDSILAQAKSYAFQATEASKNQL
                     NNLKEQWQEKAEALDDSEEIVIDITEE"
     gene            complement(29200..29583)
                     /locus_tag="VVO18_000967"
     CDS             complement(29200..29583)
                     /locus_tag="VVO18_000967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF948 domain-containing protein"
                     /protein_id="HEU5586145.1"
                     /translation="MLEVAYILVALAVIVFLVYLIITVQKLGRVIDETEKTIKTLTSD
                     VDVTLHHTNELLAKVNVLADDINVKVATIDPLFSAVADLSLSVSDLNDHARVLSKKAS
                     SAGSKTLKTGASLSALRLASKFFKK"
     gene            complement(29584..30372)
                     /locus_tag="VVO18_000968"
     CDS             complement(29584..30372)
                     /locus_tag="VVO18_000968"
                     /EC_number="2.4.99.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prolipoprotein diacylglyceryl transferase"
                     /protein_id="HEU5586146.1"
                     /translation="MLDPIAIQLGPLAIRWYALCIVTGLILAVYLTMKEAPRKKIIPD
                     DILDFILVAFPLAILGARLYYVIFRFDYYSQNLGEIFAIWNGGLAIYGGLITGALVLY
                     IFADRKLINTWDFLDIAAPSVMIAQSLGRWGNFFNQEAYGATVDNLDYLPGFIRDQMY
                     IEGSYRQPTFLYESLWNLLGFALILIFRRKWKSLRRGHITAFYLIWYGFGRMVIEGMR
                     TDSLMFFGLRVSQWLSVVFIGLGIMIVIYQNRKKAPYYITEEEN"
     gene            complement(30365..31300)
                     /locus_tag="VVO18_000969"
     CDS             complement(30365..31300)
                     /locus_tag="VVO18_000969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HPr kinase/phosphorylase"
                     /protein_id="HEU5586147.1"
                     /translation="MSVLVKEVIEKLRLDIVYGEPELLEKEINTADITRPGLEMTGYF
                     DYYTPERIQLLGMKEWSYLISMPSNSRYEVLKKMFLPETPAVIVARGLVVPEEMLKAA
                     RECKIAILTSRAATSRLSGELSSYLDSRLAERTSVHGVLMDIYGMGVLIQGDSGIGKS
                     ETGLELVKRGHRLVADDRVDIFAKDEITLWGEPAEILKHLIEIRGVGIIDVMSLYGAS
                     AVKDSSQVQLAVYLENYDTHKTFDRLGNNAEELEVSGVAIPRIRIPVKTGRNISVVIE
                     AAAMNYRAKEMGFDATRLFDERLTSLIARNEVQNA"
     gene            complement(31430..31606)
                     /locus_tag="VVO18_000970"
     CDS             complement(31430..31606)
                     /locus_tag="VVO18_000970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000048061.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /protein_id="HEU5586148.1"
                     /translation="MSKTVVRKNESLDDALRRFKRAVTKAGTLQETRKREFYEKPSVK
                     RKRKSEVARKRKKF"
     gene            complement(31746..32453)
                     /locus_tag="VVO18_000971"
     CDS             complement(31746..32453)
                     /locus_tag="VVO18_000971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269928.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="HEU5586149.1"
                     /translation="MKVIKVENQVQGGKVAFEILKEKLANGAQTLGLATGSSPLEFYK
                     EIVESDLDFSNLTSVNLDEYVGLDGDNPQSYRYFMQENLFNQKPFKESFLPRGVKDNA
                     EAEVERYNQILADHPVDLQILGIGRNGHIGFNEPGTPFDSQTHLVELDQSTIEANARF
                     FAKIEDVPTQAISMGIKNILDAKSIILFAYGESKAEAIAGTVSGPVTENLPASSLQNH
                     PDVTIIADAEALSLLEK"
     gene            32604..33632
                     /gene="queA"
                     /locus_tag="VVO18_000972"
     CDS             32604..33632
                     /gene="queA"
                     /locus_tag="VVO18_000972"
                     /EC_number="2.4.99.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="HEU5586150.1"
                     /translation="MNTADFDFHLPEELIAQTPLEKRDASKLLIVNRETGEMQDKHFH
                     SIIDMLEPGDALVMNDTRVLPARLYGQKVETGGHVELLLLKNTSGDEWEVLAKPAKRL
                     KVGTRISFGDGRLSAVVTEELTHGGRIVRFEYQGIFLEVLESLGEMPLPPYIHEKLDD
                     RERYQTVYAKESGSAAAPTAGLHFTKELLAEIQAKGVHLVYLTLHVGLGTFRPVSVDN
                     LDEHEMHSEFYQLSEEAAATLRSVKKNGGRVIAVGTTSIRTLETIGSKFDGQIQADSG
                     WTNIFIKPGYEWKVVDAFSTNFHLPKSTLVMLVSAFAGRELVLDAYHHSIQEHYRFFS
                     FGDAMFIY"
BASE COUNT        10237 a         7817 c         6548 g         9633 t
ORIGIN      
        1 tcaaaaatac ttggatcaca cacattatag gaattaacgt ttttgaaatt gaaaaatatc
       61 ccaataaata aactataaac aacaataata gaactatatt atatttctta ttcaaaacat
      121 tcctccctat atttttgatt accaatctta atcatttaca actacattct aacaaactat
      181 aaaagcgttt gtcgaattga atttatcaag caagcaacca actatctcat cttttttcta
      241 tttctgccaa tatgcgtgac aggtaataat gatagccaaa aatagcaaga gcaagcaaga
      301 cgataagagc tcctactccc aagttgatgg caaggatagg ggagagagac tgaaccaaga
      361 atatgctccc aattacaagg gccatcagga ttgcactata aataaacaat aaaactatgg
      421 cgactatgcc atttgaacga ttcaccaggt ccgtaatgct actccaattg gttgacagat
      481 ttttaacgtc cttaaagtaa tggtggcaag aaaggatgac actggcaatg atccagacta
      541 caagaaggta aatcatcgaa aggatggaca agcctagata tagagaaaga ccgagcaaag
      601 tcagaattgg taaaaaggac tgaacagcaa agataatcca aaatttcact ttcacataac
      661 gagcaaagtc aaagggtaaa ctcttcagaa aatcaagatt ttccctctcc aaggacaagg
      721 caattgaatg caggctggtg atattgttat tgacaactgc tataaacact cctacaaaaa
      781 acaagggtaa ccagtatgga ggatgaatgt ctggaactat ctgagaatct cggattttgg
      841 aaatcagact gatcatcatg agataaggaa ggaaagcact tgtaaaaagc actgtaatca
      901 cgccagtccc ctgtcccaag agggtgaggt ggtagcgtaa aaccatacgg aaaaagccct
      961 ttttagtagt tgaaatcctc tccttgctgc gacgttcttt tttgaccttc tcctcactgt
     1021 taagcaggat cacgtcataa aaacgaggaa ggaccttctt tttggtcagg taaagcaaga
     1081 aaacagttaa agctatccaa gcgagcagac ccaatatggc ttctattgaa aaaggctcca
     1141 ctgctatttt gtaaaagata tgaagaggat aaaggagaaa tggaatgtct ctaactttgt
     1201 caacaatact tccaaaagtc gactgtagaa agaagacaaa tattaaaggt atgagaactc
     1261 ctatcccaat catcacattc gaaaaaatag actgatactt tctgaagacc gtagtttgag
     1321 ccaagaaatg cactgctact accatcacta gagccacaga gacaaataat aaggtcaagg
     1381 acagtagcat caaaggcaaa cccagccata gagaaggagc tagcctaatg tagaggacta
     1441 gaaaataagc taggattggt acaattccag ttagagctgg caaaaggaca gacagtcctt
     1501 tagcaattat aatctctgat tctttaaagg catagggcct atacgatacc aaatccttac
     1561 tctcataaaa gacattgtaa aaggccgtta aagaagttga aaaggcaatc actagtaaaa
     1621 tagcaaccat cgagctaaaa taaataggta tttcctcaaa aggaaaatga atggctatat
     1681 tactaaaaca gatgagcatc aagagactgg aaaaaatgta agaacttagg actctagcgg
     1741 aaacatttac ttttttccca ggattcttag cctgcttctt tcgtagatta gccagattag
     1801 cttcttgaga tgaatagagg atattgatat caactaattt tttaatgacc ttgagacgca
     1861 tccgcaacct cctcttttct accagcaaga ctaaggtaga tactttccaa agactggtct
     1921 gggtggtctt tcctcaagtc ctctacctta ccacaataaa tcaaatgccc ctttttcaaa
     1981 atggcaatcc gatcacagac ttgctctgcc acctctagga catgagttga aaacaagact
     2041 gtcttccctt tttgtgcatg ttccttcatc atctgtttca aatcaaaggc agcctgggga
     2101 tccaaaccag tcaagggttc atccaagacc caaatatcgg gatcagacaa gagtgctccg
     2161 atgacaaaga ctttctgacg cattccgtga gaaagagttt caataacctg atagcgattt
     2221 tcagcaaaat caaaaacgtt caatagccta gctagactag cctccaagtc agatctactc
     2281 agatcatagg atgaggcgat caattcccaa aattcattgg ccgttaagcg taaaaataag
     2341 tcaggcgagt ctgctacgta gccaatcttt cgtttaatag ccaagcgatt ttccgataac
     2401 tcctgaccgt ctaccaaaat acgaccactg ctgggtgaaa tgatactgac tagggatttt
     2461 atggtggtcg attttccagc cccattatga ccaatcaagc ccataatctc tccattttca
     2521 atctgcaaat tgagattact caaggcctct ttatcaccat acaacttact aacattttga
     2581 aattcaatca tgggacaact cctatcttta tctgtattat acatcgctat actagcactt
     2641 tgatacaaaa aaatcaatac tttattttaa gtagttaaaa tagtttcctt ctatcttacg
     2701 caaacgtttg cgccaagaga tactttatga tagaataaag aacaagattg acaagtaaga
     2761 ggaaacatca tgcaaaatca aacactcatg caatactttg aatggtatct gccccacgac
     2821 ggtcaacact ggacgcgtct ggctgaaaat gctccacacc tagctcatct ggggatcagt
     2881 cacgtctgga tgccaccagc cttcaaggca accaacgaaa aagatgtcgg ctatggggtc
     2941 tatgacttat ttgacttagg agagttcaac caaaaaggga ctgtccgcac caagtatggt
     3001 ttcaaagaag actatcttca agccattcaa gcccttaaag cacagggaat tcaacctatg
     3061 gccgatgtag ttctcaacca caaggctgct gccgatcaca gggaagcctt tcaggtcatc
     3121 gaagttgatc ctgtagaccg tacagttgaa cttggagaac ccttcaccat caatggctgg
     3181 actagtttta ccttcgatgg tcgccaagat acctataatg gcttccactg gcattggtac
     3241 cacttcactg gtacagacta cgatgccaaa cgcagtaaat ctgggattta tctgatccaa
     3301 ggggacaaca agggctgggc taacgaggaa ttggtcgata acgaaaacgg aaactacgac
     3361 tacctcatgt atgccgacct agactttaaa catcctgaag tcatccaaaa catctatgac
     3421 tgggctgatt ggttcatgga aacgactggt gtagctggtt tccgtttgga tgccgttaag
     3481 catattgact ctttctttat gcgcaacttc atccgcgata tgaaggaaaa atacggtgac
     3541 gatttctatg tttttggtga attttggaac ccagacaagg aagccaatct ggactatctc
     3601 gaaaaaacgg aagaacactt tgaccttgtc gatgttcgtc tccaccagaa tctctttgaa
     3661 gccagtcaag ctggcgcaaa ctatgacctt cgtggcattt tcacagatag cctggttgaa
     3721 ctcaagcctg acaaggctgt gacttttgtc gacaaccacg atacccaacg aggacaagcc
     3781 cttgagtcta ccgttgaaga atggttcaag ccagcagcct atgccctcat tttgttacgc
     3841 caagacggcc ttccatgtgt cttttacgga gactactatg ggatttcagg ccagtatgct
     3901 caagaagatt tcaaagaaat ccttgaccgc ctcctagcca tccgaaaaga tttggcctat
     3961 ggagaacaaa atgactactt tgaccatgct aactgtatcg gttgggtacg ttcaggtgct
     4021 gaaaatcaat ccccaatcgc agtccttatc tcaaatgacc aagaaaacag caagtcaatg
     4081 tttgtcggtc aagaatggac taatcaaacc tttgtagatt tacttggtaa ccaccaaggt
     4141 caagttacaa ttgatgagga aggttatgga caattccctg tctcagctag atccgtaagt
     4201 gtctgggcag tcaataccat ctaatagctc ataataacca agctaggtcc aagcggattt
     4261 ggcttttttg tattcacaaa aagacctacc caaatggata gatctttact tgattacaat
     4321 ttacctgcta ctgcatccaa caattcttgg atcttagctt ggttgcttcc tcctgccatg
     4381 gccatgtctg gtttaccacc accacgtcca tcgatgattg gtgctaattc tttgacaagg
     4441 tttcctgcat gaaggtcttt tgtcttgctt gctacaagga cattgacttt gtcaccgata
     4501 gcggcaacta ggacaagaag atcagagtag tctttttgtt tccagttatc tgcaaaggta
     4561 cgaagggcac ctgcatcgga tacagacact tgactagcaa tgtaacgatg accgttgact
     4621 tccttaacat ctttgaagat atcgcctgcg gctgcagctg cggctttttc tttcaactca
     4681 gcattttctt tttgaagttg acgaagttgt tcttgaagtc cttctacctt gtgaggtact
     4741 tccttgactt gaggtgcttt caaggttgct gcgatagctt taagagcatc ctcttgttca
     4801 cgataggctt caaaggcttc cttaccagtc actgccaaga tacggcgagt tcctgaaccg
     4861 attccttctt ctttgacaat tttgaagaga ccaatctcag aagtgttgcc aacatgagta
     4921 ccaccacaaa gttcaataga gtagtcaccg atagtcacga cacgaacttc cttgccgtat
     4981 ttctcaccaa agagggccat agctcccatt tctttagcag tgtcaatatc cgtttcaact
     5041 gtcttaactt caagagcttc ccagattttt tcgttgactt gctgttcaat cgcacgcaat
     5101 tcttcagcag ttacagcttg gaagtgggta aagtcaaagc gaaggaattc aacttcgtta
     5161 agagatcctg cctgtgttgc gtggtttcca aggatattgt gaagggcagc gtgaagcaaa
     5221 tgagtcgcag tgtggttttt catgacacgg tgacggcgat tgctatcaat tgccaaggta
     5281 tattcttggt tcaaggcaag cggtgcaagg acttcaactg tatgaagggc ttgaccattt
     5341 ggggctttct gaacattggt cacagtagcc acaaccttac ctgactcatc caagatttgt
     5401 ccgtggtcag cgacctgtcc acccatttca gcatagaatg gcgtttccgc aaagataagt
     5461 gaggtagttc cttctgatac agcttctact tctgcattgt ccgccacgat agctaccaat
     5521 ttagaagaca attggctagc attgtggttg aagacacttt ctacagtgat gttttgaaga
     5581 gtttcatttt gcatacccat tgagccaccc ttgacagctg acgcacgcgc gcgttcttgt
     5641 tgttctttca tggctgcttc aaaaccttca cggtctacag tcataccagc ctcttcagca
     5701 atttcttcag tcaattcaac tgggaatccg tatgtatcat agagtttaaa gacatcttga
     5761 ccagcaatga cagattgacc tttttctttc aagtctgcca caatgccttg ggcaaagtgt
     5821 tgacctgagt gaagggtacg ggcaaatgat tcttcttcgc tcttaacgat tttctcaata
     5881 aagtcacgtt tctcaagcac ttctgggtag tagctttcca tgatgtttcc aacagttgga
     5941 acgagtttgt aaaggaaagg ctcgttgata cccaattttt gaccatgcat agaagcacga
     6001 cggagaagac gacgaagaac ataaccacga ccttcatttc ctggaagggc accatcaccg
     6061 atggcaaatg aaagtgaacg gatgtggtca gcgatgacct tgaagctcat gttgtcgcca
     6121 tcttggtcat aaaccttacc agacaatttc tcgacttcac ggataatcgg catgaagagg
     6181 tccgtttcaa agttggtctt agccccttgg gtaacggcca ccaaacgctc caaaccagcg
     6241 cccgtatcaa tgttcttatg tggcaattcc ttgtattcgc tacgaggaac agcagggtct
     6301 gcgttaaatt gtgacaaaac gatgttccag atttcaatat aacggtcgtt ttcaatatct
     6361 tctgcaagca ggcgaagacc gatattttct gggtcaaagg cttccccacg gtcaaagaag
     6421 atttctgtat ctggtccaga aggtcccgca ccgatttccc agaagttgtc ctcaattgga
     6481 atcaagtgac ttggatccac tcccacttca atccagcggt tgtaagaatc tttatcgtct
     6541 ggatagtagg tcatgtaaag tttttcagca gggaaatcaa accattcagg gcttgtcaaa
     6601 agctcataag cccaagtgat agcttcgtca cggaagtaat ccccgataga gaagttcccc
     6661 aacatttcaa acatggtatg gtgacgcgca gtcttcccta cgttttcgat gtcgttggta
     6721 cggatagcct tttgggcatt ggtaatacgt ggattctcag ggataatggt cccgtcaaag
     6781 tatttcttga gggttgctac cccagagttg atccacaaaa gagttgggtc gtttacagga
     6841 accaaactta ctgatggttc tactgagtga cctttggtcg cccagaaatc aagccacatt
     6901 tggcgtactt gtgcactaga tagttgtttc atattgtctc cttatttact tgtttaatgt
     6961 gattggcttt ccagcatttc cacatagtca atcgcgacac agagggaaat gactaggtct
     7021 gcataagcgt cctcaagaac cgttacggta taggtagagg tcagatggaa gagttccttc
     7081 ttaatttccg caatcagctg atcgcgatca tccagcaatt tgaaattcaa atcccagata
     7141 ttgccctcga tacgaagacc tagattatca aactcatact tatctcgcca gaaggtcaac
     7201 ttcttacgaa tgacaaaact cgagccatcc cgaagctgaa tctcaaaacg aggaagcaag
     7261 gtcaagattt ctttactaat ctcactgact tgttcaccag ccgcatcata gatggtaaag
     7321 gttttaggaa tcttaaaaaa tgatccctcc acctgatagg caatttctcc cctgtcatcc
     7381 ttgatagcga agcgttcgcc tccaagacga aacttttgtt tgacaagaaa tgttttcatc
     7441 aacacctcca aaaatcaaaa gacaagctca tatcacgaag ggcgaaaaac cgcggtacca
     7501 ccttcattca atgaacttgt cattctcttg ttcttatgca attgtatgat tgagtagcat
     7561 gacttcctag cttagatggc tcgcagcacc gccatttctc tggactaaga caagtgaaaa
     7621 tcaattctca actttcttat tataacgttt ttttaagctt gcgtcaactg gaaatgatct
     7681 ccgttgaatt agaccaattc cctacatctc tgattacttt ttcaggatat attttttctt
     7741 actgccgttt ttctttttat cccaaatttt catattacta aacacagcta ctagaatatt
     7801 tccaaatata aaggtgccta tcacccaata tatggactca gttgttaggt attgtcgatc
     7861 caagccatcc tttaaatggg atagtataac agtttggtta acaatcataa aggttggcca
     7921 gaaacttttt ttgaaaaaag tagacatttt cattatttgt tgccgctttc tgtaaggtta
     7981 atactcaata aaaatcaaaa agcaaactag gaagctagcc tcaagctgta cttgagtacg
     8041 gcaaggcaac gctgacgtgg tttgaagaat ataggcttag tatactacta ggcaagcaaa
     8101 taagcaacta gaatagaaaa agatagggtt ctaaaaactg acttctattc cttaaaaacg
     8161 aaccagcttg actgattcgt cttcttacgt ttatctccta cttccgatac attttaaact
     8221 gtaggaagag gtcgctatat ttccctgtcc atttatggtc aaatttctca taaacttcta
     8281 ggtgtttcat ggtttcaaca tctggataga aggccttatc ttcctttgtt tcctctggga
     8341 gcaattcctt cgctggtagg tttggtgttg aatagccgac atactccgca ttttggagag
     8401 cgttttcagg tttcaacata aagttgataa aggcataggc tgagtcttgg tttttaactg
     8461 ttttgggaat gaccatattg tcaaaccaaa gattgctggc ctctgtcggt accacataac
     8521 gtagattttc atttttttct aacatttggc tggcttcacc agagaaggtc acgccgattg
     8581 caacattatt ctgaatcatg tagcccttca tctcgtccgc aacgatagcc ttgatatttg
     8641 gagtcagttt gtagagctta tccactgtct cttccaactg ctgcggatcc ttggagttga
     8701 ggctgtagcc gagggaattg agtcctagtc ccagcacctc acgcgcccca tcaaaaagca
     8761 tgatagaatt cttatactcc agcttccaaa ggtcatccca atgctcaggc gcttcatcta
     8821 ccatggtttc gttgtagaca attcctaagg ttccccagaa gtaagggatg gagaatttat
     8881 tacctgggtc aaaggactgg ttgagaaact ctggtccgat attttcgatt ccttcaattt
     8941 ttgaataatc aagcggaacc aagaggtctt cgtccttcat cttgttaatc atgtattcac
     9001 ttggaatggc aatatcgtag gtcgttccac cctgctttat cttagtgtac atggcttcgt
     9061 tggagtcaaa agtctcgtac tgaacttgaa ttcctgtttc ttctgtaaac tgagtcaaga
     9121 gttcaggatc gatatagtct ccccagttat agataaccaa tttttgacta tctcgactat
     9181 tgattttact atctaaatga gtcgcaattc cccacaagac aaggataatc gctgcaattc
     9241 ctgctaaaaa tgaatagatt tttttcatgc ttgctcctcc ttctcacgag agataaagta
     9301 ataacctaca actaggataa tactaaagag aaagactaga gcagacaggg cattgatttc
     9361 taaggaaatc cccttgcgag cacgagagta aatctcgact gatagggttg aaaagccatt
     9421 tcctgttaca aagaaggtca cggcaaagtc atctaacgaa taggtgaagg ccatgaaata
     9481 accagtaatg atagacggag tcaggtaagg aagcatgatt tccttgaaca tctgaaattg
     9541 actagctccc aagtcatagg ccgcatgaat catgtcgcca ttcatttcct tgagtcgagg
     9601 caagaccatc aagaccacga taggaatgga gaaggccacg tgactagata gaacggtcaa
     9661 aaagccaagt gaaaacttga gttgggtaaa gagaatcaag aagctagcac caatcataac
     9721 gtcaggcgca accatgagga tattattgag tgatagaaag gcttcttggt atttcttacg
     9781 agactggtag atgtaaatgg caccaaaagt cccgataatg gtcgctatca aggctgatag
     9841 gaaggccaag aaaaatgtct gagccaaaat cagcatgagt ctcccatctc caaacatggt
     9901 ttcaaagtga gtccagctaa aacctgtaaa gctattcata tcatcaccag cattaaaggc
     9961 atagccaatc aagtaaaaga taggcaggta gaggaccaga aagaccagtc ccagataaag
    10021 gttggcaaat tttttcatcg ttctctcctt tccttagtca cccacatggt gatgaacatg
    10081 gtcaggatga gaatcacacc gatggttgaa cccataccat agttgtcatt ggttagaaaa
    10141 ttctgctcaa tagccgtccc caaggtgata acgcggttcc caccaatcaa acgggtcagc
    10201 atgaagagac tcaaacttgg gataaagacc gactgaaccc cacttcgcac accgttcata
    10261 gatagaggga agatgacatg acggaaggtc tcccacttag ttgcaccaag gtcataacta
    10321 gcattgatga gattattatc catgtcgtct aagacattga aaatcggcaa aatcataaag
    10381 gggagctcga tgtagcttgc gacaaagata aaggaaaaat cggtaaaaag caactgttgt
    10441 gaaccaattc cgataaattc caagaattgg ttaatagagc cattttgacc aaaaatcccg
    10501 ataaaagcat aggctttaag gagcaaattg atccaggtag gaaggataat cagcatgagc
    10561 cagagttgac ggtgcttgag acgggtcaaa aagagggctg ttggatagct gataagcaag
    10621 gtcacaaagg tcacaatccc tgcataaagc actgagttga aactcatttt gaggtaggtc
    10681 aagttttgtg acgcaaagta agatttataa ttttctaaac taaactggcc ttcaatgttg
    10741 aaaaaggatt gtccgaaaat caagaccaag ggtgccaata caaagagggc aatccaaagc
    10801 atgtagggca ctacaaagag tttagagctt gttttcttca tctctttcct cctcgatcgc
    10861 attgatcaga cctgcttctt gctcttcgat ttccacgtat tcttcgatac gagcatcgaa
    10921 ctcttcttcg gtttcattga gacgcatgat gtggatgtct tctgattcaa agtccagacc
    10981 gatttcctca cccacgatgg ccttacgggt tgagtggatc atccattcat ttccaagttc
    11041 gtcataggcg ataatttcat aatgaactcc acggaagagc tgggtgtcga ccttaacttg
    11101 gagtttgcct tcttcaggaa gggtaatgcg caagtcctct ggacgaataa cgacctcaac
    11161 aggttcattt ggcttcatcc caccatcaac cgcttcaaag cgtttgccgt taaattcgac
    11221 caagtagtcc tcaatcatgg tacctggcaa gatgtttgac tccccgataa aggtggcaac
    11281 aaagtggttg attggctcat cgtagatgtc cacaggggtt ccagactgga caatctcgcc
    11341 atcattcata acgaaaatcc agtcactcat ggcaagagct tcttcctgat cgtgagtgac
    11401 aaagacaaag gtaatgccca atcgttgttg taattcacgc aattcgtact gcatgtctgt
    11461 tctcaatttc aagtccagcg ctgataaagg ctcgtccaac aagaccacac ggggttggtt
    11521 gatgatagca cgggcgatgg ccacacgctg acgttgtcct ccagaaagtt tgcggatgga
    11581 acgtttttca taaccttcca actgaaccat cttgagaact tccgctacac gctgctcgat
    11641 ttctttctta tcaattttac gcaagcgaag tggaaaggca acattttcaa acacattcat
    11701 atgtgggaac aaggcatagg attggaagac ggtatgtacg tcgcgcttgt tggttggaat
    11761 atcattgata cgaacaccgt ctagcatgat atctcctgtc gtcgcatcca gtaaacctgc
    11821 aataatgttt aggatagttg atttccccga accagatgca cctagaaggg tgtagaattt
    11881 cccttcttcc aactcaaagt tgatgtcttt gagaaccttg gtgttgctgt cttcaaaaac
    11941 tttagagacg tttttgaatt cgataattgg ttttttcaat tggcataaat tccttctttt
    12001 tcatagatta accgatcggg gctctgtcag gtccccacta cctcttgcag ggagtaaaac
    12061 cacctgcata catcttcgct accgataggc tttcacccaa gatccggact tctctttcaa
    12121 gcgtaatacc tgagtgttcc ttgacttttt cgataaccga ttggatcaag tcctcgtagt
    12181 ctttggccgt tccatctgcg acattgatca taaatcctgc atgcttttct gacacttcta
    12241 cgccaccgat acgatagcct ttcaagccag cttctgaaat taactgacct gcaaaatgcc
    12301 cgactggacg cttaaagacc gagccacaag atgggtattc caaaggttgc ttgagttcac
    12361 gtaggtgcgt caagcggtcc atttcctgct tgataacctg atgggttcct ggagctaggg
    12421 caaatttaac tgacaagaca actgcaccag actcctgaat agctgaatgg cggtaaccaa
    12481 aagccaagtc tttagcagac agggtttcga tttctccatc cttggtcaag accttacaag
    12541 actgcaagat gtgagcaatc tcgccaccat aggcacccgc attcataaag acagcaccgc
    12601 caacgcttcc tggaatacca caagcaaact caaagccagt taaactatga cggagggcaa
    12661 tgcgagttgt ttcaatcaag ttagccccag cttctgcttc aatggtatag ccatcaacag
    12721 aaacgttatt gagcttgtca cacaagatga caaatccacg aatcccacca tcacgaacga
    12781 tgatattgct tgcattgcca agaaccatcc aagggatatt ttcttggttg gcaaatttca
    12841 caacgcgagc caactcaaaa cgatttcgtg gaaagaccaa ataatcagcc tctccaccta
    12901 cttttgtata actatagcta tgcaagggtt ccttaaaacg gatatcaatt ccttctaaga
    12961 tttcaagcat tttttctctt acagacatgt cactcttcct tttacaaaat tcattccatt
    13021 ataccatttt tagagacatt tgacgaccat aaaaatacct tgtttggatt ttgcataaga
    13081 aaaagaggtt cccccctttt tatgattttt tacaaaagat ttccttggtt ccataggcga
    13141 tcagaacgag ctccagtgct agaatcactt caaccaagac tggatttgtc aaccagccta
    13201 cttggaaaag agatggtgcc agatcaaaga aggcatgcaa gccataggct gttaggagat
    13261 aaatccattt cttctggcga acagcttgat aaacccaaac tgtcaaaagt aattggaaac
    13321 caagcgccaa gattcgctca aaaccaagca aataaatctg ccagaccgaa agtgactgaa
    13381 tggtttttaa catattttca gacagtaatt gcataacctg tggattctga gtttgaactg
    13441 ccgaaagaac aatgtaaaga ttgagtaaac tagtaaggcc tagaaaaatc aactccaagc
    13501 caccatgccc cagtccatag gccaaggcgt ctgccttttc caaacttatc tttttctcca
    13561 accatttgaa gaaaacaaga cgagccgttt cctcaaaaaa tgctgccatg gctaggccat
    13621 agataatata gacaagcggg tgatcttgca agagggcaat actaccgtct ttttgaggat
    13681 gcaaaatcaa gatatgcacc agtttttcca aaatctgcga agagacaaag aaagcgactg
    13741 cacccaagcc caagacagct agattaatct ggtatttctt tttggcaaac caaatgcttc
    13801 ctatcagaaa agctagcaac agcaacatgg taataatgat atgaatggtc attttcttct
    13861 cctattctgc cttttcaata tcttttttca tctcgtcaac attgaactta gcaaacaagt
    13921 attgacggtc ttggactggg aaacgttggt ccaactggtc aactgctccc acctcgataa
    13981 tgccttcctt gatgacaaaa tccatgacat gtccaccgaa ggtcaaatca tctgatatga
    14041 agtgcagatg gtagcctgcc acactgaccc catggaaaat ctcaggcgtc cagaaaccaa
    14101 caatagtccc cacaacattg tcacgactat attccggttg atgggttgcg acatcagcaa
    14161 acttggtatc gggtgttgac ttaggaatca tacgcacatg catatgtgaa aattctcccc
    14221 gaatcttgat agagcggaaa agattttccc catcataata agactcaatt cgttcttcca
    14281 attccttgtc tgtcatctca aagcgctggc ggaaaatgac ctctgcctga tgcggtacta
    14341 ctgctgcata aggaataagg gcatctggtg acacttccac aatttctggc tgttctcctg
    14401 ttccttttgc ctgataagcc ttgccatcta agacaatcaa ttccccatca atagaatcca
    14461 aggttcccaa accaaggtca ccatgctcta gcaattctcc cactgtcatg gtaccaccat
    14521 aaaggccagc catcaaggct ccaagagtat tgtattgaaa taatttcact ggttcctgca
    14581 cgttcttatc cattcacttt cttgtctgtt attctataaa tcttactcct aagtatacca
    14641 catttgcccc tagatgtgaa cgagagaaac gctctagaca ttgccaagaa ggaaaaaaaa
    14701 gggtacaatg taacaaaatc aagggaggtc tggaatgaag agacaaagca agtacaaaga
    14761 ggtcgtttcc tatctgaaaa atggtatcga gtctggacga tttccgacgg gtagtcgcct
    14821 gccttctatc cgtcaactga gccttgactt tcactgcagc aaggacacca ttcaacgagc
    14881 cctgctggaa ttacggcacg aacaatacct ctatgccaag cctcagagtg gctactatgt
    14941 attagaacaa gggcaacatc aagacctaga aatcgaggtt accgacgaac atgccagtgc
    15001 ctatgacgat ttccgactct gtgtcaatga aaccttgatt ggccgagaaa actacctctt
    15061 caactactat gacaatcaag aaggattaga agacctaaga cagtccattc acaaactcct
    15121 ctttgagcaa gctctctact gcaaggctaa ccaactagta ctgacttctg gaacccaaca
    15181 agccttgttt atcctctctc aaatatcctt tcctagacaa gccaaggaaa tcttggtgga
    15241 acagccaacc taccatcgga tgaatcgcct cttgattgca caggggctgg actatcaaac
    15301 gattgaacga ggcattgatg ggattgactt ggaggagctg gaaggccact tcaaaacagg
    15361 aaaaattaaa tttttctaca ccattccccg atttcactat cctctgggac attcctattc
    15421 tgagcaagac aaacgatcta ttcttaactt agctgccaag tatgatgtct atatcgtaga
    15481 ggacgattat ctgggtgatt tggactccaa gaagggccaa accttccact atcttgatac
    15541 agaggagcgt gtcatttata tcaagtcctt ctcgaccagc ctttttcctg cccttcgtat
    15601 tacagcactc attcttccaa atgctatcaa agaagcattt atggcctaca aaaatatcct
    15661 agactacgac agcaacctca ttatgcaaaa ggccctgtca ctctatattg acagtcaatt
    15721 gtttgaaaaa aatcgtttgg ctcgcttgac caatcatgaa tcttaccaaa aacaaatcga
    15781 ggaaaggata actaaaacac cttgtcccct tcctcattat cccctacacg atggtttatt
    15841 gctagacctg agacagtatc ctaaaatcgc cagtctcaaa cacagtcaac tgggcttgga
    15901 cttctttgaa gaggcctatt taagcacctg tccttatcaa tttgccaagg tgtccctaga
    15961 caatctggaa aatgttttaa actatttaaa agcagaattg gaatgacatc caactctgct
    16021 ttttcttatt cttcaacttc agttagactt gctgcttttt caagatagct ttggtaagtt
    16081 ccttcatcct taagtttttg gatgaccttg tctaccactt ctttcaaatc atcactattt
    16141 tttctaagtg caacggcatt ggcgtcgccg tccttcatct tcaagctgac agttgcgaca
    16201 gctaagccag cgtttttagc agcataacta agtgcaacag gctcatccat atgaacagca
    16261 tctatttttc cagcctgcaa ttcattgact gcttcaccca tattagttag ggaagttaat
    16321 tgagcttttg gcaattgttc cttgaccatt gattctggaa cagtcccttt ttgggctgca
    16381 atattagcac tttctaggct agttaaatcc ttgtattttt ccacatcagc cttacgaacc
    16441 aagaaactaa tcttgttttc atagtatggg attgaaaaat caaagacttc ttttctctcg
    16501 tcagtagcac taattcctgc aactgctagg tcagccttac cagtttgaag actggtcaaa
    16561 acattgtcaa aactcatgct taagatttcc aacttaaccc caagttcatc agcgatagct
    16621 tgagccatgt cgatgtctgc accgactacc tggttctttc catcaaccaa tgattgaaat
    16681 tcaaagggtg catagtcagg actggttgcc acaactaatt tccccttttg cttaatggcc
    16741 tcaacagctg actgagaacc attagaacct gactggcaag ctactaagaa gaaacttgca
    16801 agaaaattac ataaaacaaa tatccatttt tttgatttca taaataaaca acctttctgt
    16861 taattttgta taattataac aatatccaag ttacttgtca agtgtttttt aaatttttat
    16921 ctcaaaaata ttttttcgtt caaaaaaagg agccatcagt tgatttcaag ctccttttta
    16981 tacagaatta aactatttta tagttcgaca atcttacctg tttcaaagta gacaacccat
    17041 tcacagatat ttttagcata gtcaccgata cgctccaagt aggaaataac ttggaaataa
    17101 tcacgacccg taacaatggc ttctggattt ttcttaatct cttcagtcgc aaggtcacgg
    17161 atagtttcaa aatagtggtt aatttgctca tccatggagg ccacccggta tgcgtcgtca
    17221 acagaaccat taagataaag atcaagtgct gcttcaacaa cgcttttaac ttcacgtccc
    17281 atttttttaa tttcttcctc tacagctggg atgcgttctt cccccttcat acggatggtt
    17341 gcctgggcaa tggctacagc gtgatccccc atacgctcca catctgatac agccttaagg
    17401 acagtcaaga ctgtacgcaa atcttgagag actggttgtt ggagtgcgat catttcaaat
    17461 gatttctttt ccagtttcac ttcgtattca tttacttctg catcatcttc tatgacctct
    17521 tttgccaggt cacggtcatg cgtgacaaaa gcacgtaccg tacgattgat ttgtgagagc
    17581 acttcttgtc ccatagcgta gaactggtta tgtaatttct ctaaatcttc ttcaaattga
    17641 gatcgtaaca tctttcatct ccttatccaa attttcctgt aatatagtct tccgtttcct
    17701 tgtgttgggg atcaaggaac atctgcttgg tatcattaaa ttcaatcaaa tctccatcta
    17761 ggaaaaatcc tgtcttatca gagatacgtg aagcttgctg catggaacgg gttaccagaa
    17821 gcatggtgta cttgtctttt agaccataca aggtttcctc aattttacca gctgaaatcg
    17881 gatccaaagc cgaagttggc tcatccaaga ggatgatttt aggactagtt gccaagacac
    17941 gggccacgca gacacgctgc tgttgaccac ctgacaatcc aatagctgaa tcatatagac
    18001 gatccttgac ctcatcccag atagaggcac cttgcaaggc tttttctacg gcttcatcca
    18061 gaacctgctt atccttaatt ccattgatac gaagcccgta gacaacattc tcatagatag
    18121 tcatagggaa aggattaggt tgttggaaaa ccattccgat ttccttacgt aattcaaccg
    18181 tatctgtacg cggactgtag atgttgtgac cattgtacac cacggatcca gttgtggtca
    18241 cctctggatt gagatctccc atgcggttga gagacttgag gagggttgac ttccctgatc
    18301 cagatggacc aatcaaggct gtaatttcct taggttggaa agatagggaa acactattca
    18361 aagccttctt tttattataa taaacggaca ggtctgatac ctgtaaaatc gcatctgtca
    18421 tacggtttcc tttctaacca aagtgaccag atacatagtc attggtggac tgtagcttgg
    18481 cattttggaa aatagttgca gtcttgtcat actcaatcaa atcacccaag taaaagaagc
    18541 ctgtatagtc acttgcacga gcagcctgct gcatattatg cgttacaatg atgatggtaa
    18601 agtttttctt gagctcaaac atggtctctt ctagttgcat ggtcgcaatc ggatccaagg
    18661 ctgaggctgg ctcatccatt aagaggatat ctggcttaac agagatggca cgagcgatac
    18721 agagacgttg ttgctgacca cctgataagg tcaaggctga cttgtggaga tcgtctttaa
    18781 cctgatccca gagggcagcc tgacgaaggg aggtttctac gatttcatct aggacttgct
    18841 tatccttaac tccagcacgt tcatgcgcaa aggtaatatt acggtaaatt gacttagcaa
    18901 atggattggg gcgttgaaaa accattccaa tgtgtttacg catttcataa acgttgattt
    18961 ctggacggtt gacatcaatt ccacgataga gaatctgccc agttacttta gcaatatcaa
    19021 tagtatcatt catgcgattg agactgcgta agtaggtaga tttccccgac cccgacggac
    19081 caatcaaagc tgtaatttta tttctttcaa attgcatatc aatcccctta atggattcat
    19141 ttttaccata gtaaacatgg acatccttag tagaaagggc tactttttct tcaggaaagg
    19201 taaggatatg cttctcatcc cagttatatg ttgacatggc ttctccttta ggcagcggtt
    19261 aatttcttgt gtagatagct tccgaactta cgagctccaa agttaaaaat caggataaag
    19321 atcaggagca cagcggcaga acctgctgat acaatggttc catctggaat agtgccttca
    19381 ctattgactt tccagatatg gacagccaag gtttctgctt gacggaagat agagatgggg
    19441 ctagtcacac tgaggatatt ccagttagac cagtcaagag ctggcgccga ttgccctgct
    19501 gtatagatca gagctgcagc ttcgccaaag atacgaccag atgccaagac gacacccgtt
    19561 acaatacctg gaagcgcttc tggaataaca acatgaacca ctgtctccca gcgagaaatc
    19621 ccaagagcca gaccagcctc acgttgggta tggtgaacgt gtttcaaact atcctctaca
    19681 ttacgcgtca tctgaggcaa attaaagact gtcaaggcca aggcacctga aatgattgaa
    19741 aatccatact caaactggac tacaaagatc aagtaaccaa agagacccac caccactgat
    19801 ggtaaagagg acaagatttc aatacaagtc cgcacaaagt tggtaacagg acctttttta
    19861 gcatattcag ccaagtagat cccagctccc atagaaagag gtacagaaat aatcaaggta
    19921 atgaccaata ggaaaaagga attgtaaagc tgaatgccaa tcccaccacc tgcttgaaaa
    19981 gcagaagacc ttccagtcaa gaaagaccaa gagatatggg gcaagccccg aaccaagata
    20041 tagagaatca aggaagccaa gattgtcaca atgatgctag caatcgtata gaggacagct
    20101 gttgcaagtt tatctaattt cttagcgcgc ataatttttc tttcctcttt ctttcgtaat
    20161 caatttaatc acactgttaa aaactaaact catcaagagc agtaccaagg ccagtgacca
    20221 gagaacatta ttatttacag ttcccatgac agtgttccca attcccatag ttaatataga
    20281 agttaaagtt gcagctggtg tggtcaagga agttgggata acagctgagt ttccgacaac
    20341 catctggata gctaaagcct caccaaaggc acgcgccatc ccaaagacca ctgcagtgaa
    20401 aataccagaa cgggccgcct tcaagatcac acgccagata gtctgccagc gagtggctcc
    20461 catagcgaaa ctggcttcac gataataacg aggaaccgca cgcaagctat ccgttgtcat
    20521 aaaggttacg gtcggcaaaa tcatgacaaa gaggacggaa atccctgaca aaatcccaaa
    20581 accagtccca ccaaagacac tgcgaacaaa gggaacgacg acttgcaagc caataaatcc
    20641 gtacactact gaaggaatcc caaccaggag ttcaatagct ggttgcaaaa tcttcgcccc
    20701 ttttggtgat acttcggtca taaaaactgc tgcaccaata gcaaaggggg ttgcgataag
    20761 ggctgagaga atggtaacga taaaggaacc caaaatcata ggaagggcac caaattcttt
    20821 actagaagga ttccaagttc ctcccaaaag aaagtcaaag atattcacac cattgacaaa
    20881 gaaggtcgac aagccttttt gcgctacgaa aaccaaaatc atggccacaa ggatgactat
    20941 caaagaaaga caggcaaagg tcaaaccttt tcctaatttc tccagacgag aattctttga
    21001 tggaagcaac attttcttag ctaattcttc ttgattcatt attgtctccc ttccaacact
    21061 gtcacagttc cggcagcatc tttttcaacc ttcatttcct taatcggaat atacttcaat
    21121 cctttgacaa tcccttcttg ggtctcatcc gagagaacaa aattgagaaa ttctgcagcc
    21181 aactcattgg gctgccccaa tgtatacata tgctcataag accacaaggg ccaattattg
    21241 ctacttatat tttctggact taagtcatag ccattcaact tcatgctttt gaccgaatca
    21301 tctatatagg taagagataa ataagagata gctcctggac tttttgatac gattgatttt
    21361 accgctccat ttgaatcctg ctcctgactt tgcatggcag actgaccttc cataatgaca
    21421 gtatcaaagg tagcacgaga accagagccg gctgcccgat tgataacaga gatgggtaag
    21481 tccttaccac caacctcttt ccaattggtt acctcaccta tgaagatttg acgaagttgc
    21541 tctgtcgtta ggttatcaac atcaacctcc ttattgacaa tcagagccaa gccagctacc
    21601 gcgaccttgt ggtcaacaag agcagaagca tcaattccgt ctttttcctc agcaaataca
    21661 tctgagtttc ctatatcaac tgccccagac tgaacctggg acaagcctgt accagaacct
    21721 cccccttgga cattgaccgt ttttccaaca tggatcgtgc caaattcatc tgccgctact
    21781 tcaaccaagg gttgcaaggc agttgagcca acagccgtta tggattctcc acgatcaatc
    21841 cagctagcac agcctactaa acaagccgtc agccaaaaag cgataagaga cagagcaagc
    21901 ttttttcttt ttttcactgt ttttctcctc gaaaataatt atgaatactg tgaatttttt
    21961 aagtagttct ttatgagttg acgcatgaat tcttaccaaa tttctgcgca attgattatt
    22021 tatataatat aggctatatt actctttcct aacctccttt tttcatatgt ggataaaatc
    22081 tcttgtctat cccttccccc attgtcaccc attatagtca tttcgtgtct ctttttcccc
    22141 tttttaatgc aagggaaatt actctcctta gatgataatc caaaagctag aaaggtatct
    22201 caaacctctc tactctccca gactagttta caactaaaag gaaaagattc gattttatga
    22261 gaaatctagt ttacaagcgg taagaacgct aataactaaa cttcttgtac tctttgaaaa
    22321 tctcttcaaa ccagtgtttt gagctatcta tggctagctt cctagtttgc tctttgattt
    22381 tcattgagta gtaaaactac atgtaatggc aatcaagata tcaagaatca tcctactaaa
    22441 aaaatccata ctttcactat aacatagaat aagatatttg actagcattt tcatttgaat
    22501 ctgaggcctt ttggaaaata atttttcaaa acatttccag taacctttgc aaagcccaag
    22561 ccattgcctt taaccaaaac ttggtaccaa ccatttggca gactttctgc cagctgaacg
    22621 atttctccag ccgcatactt gacaaactct tcttggccaa tttcaaccga ctgttcgacc
    22681 tgactcggtt tcaaggctaa accaagagcg aaactgggct caaagcgttt cttcttaaaa
    22741 gtacccagat gcagtccatt gcgagcaatc ttgagcttcc ctaaatctgg caaaagttct
    22801 ggcaagagat aaagctggtc tccaaaaatc tgcaagatac ccggtagatt gaccttcaaa
    22861 tggttttggg caaattcctg ccacaaggca acttgttcac ggctgaggtt actcttactt
    22921 gccttaaatt taggagctgg attgttaccc ttaaactgta gatgggcaac aaactgaccc
    22981 tctcccttaa actgatgagg gtacatccga gccgtttctg gcaggtcaat accagctacc
    23041 attccattga tatgctctac tggcaacaag tcaaaatcat actcttccag caaccaattg
    23101 acaatctctt cgttttcctc gggtgcccag gtacaggtcg aataaaccag acgaccacct
    23161 tcagctaaca tggtcactgc atcctccaga atttctcttt gcaagctaac acattgactc
    23221 ggataatcta agctccaata gtccatagca tcaggttgct tacgaaacat tccttcacca
    23281 gagcaagggg catcaagaac gattaagtca aaatagcctt taaagacctt gaccaagcgg
    23341 tcggcagatt cattggtcac cacgacattt gtcgctccaa aacgctccat gttttcaacc
    23401 aaaatcttag cccgtttgct tgaaatttca ttggaaacaa gtagcccctc ccctgctaga
    23461 taggctgcca gttgagttga tttgcccccc ggtgcagcag ccaagtccaa gaccttcata
    23521 ccaggactgg gttgggctac ttgagccacc atttgagcag caggttcttg cgaataaact
    23581 aaacctgtag catgctcagg cgatttccct gaaaccttcc catagtggcc ccaaggggtt
    23641 tgagtaatgg catcagaaaa ggaaagttgc tcttctttta agggattgac ccgaaaggcc
    23701 gaaaccgctt cctcctcaaa agaggcaaga aaatctcttg cctcatctcc tagtatttct
    23761 ttatattttt caacaaatcc ttctggaaat ttcatttaag ttcttttcct ttcgtaaata
    23821 taggactgaa tttcctcctg catctcaaga ggcaccatca tgaccggctg tctggtttga
    23881 aaatcaggag cttcaccaaa aagggtcaca acccgatagc ccagactttc ccctaaaata
    23941 ctagctgcgg cataatccca tggttgcaga taggtgagat aggtcaacaa atgccctgac
    24001 aaaatcttgg caaaactaat ggccgcactt ccatagacac gaacaccaag aaccgctcgg
    24061 ctcaaatcag ccagccccca ttcattggtt tccagcatac cactattccc tgcaatgaga
    24121 aaatctccaa gtggtttagt tttaaaagga gctaggggcc tatcatttag acaaactgga
    24181 aattccccac caccgtggta acaatcccct ttgaccacat cataaatcag accaaactgt
    24241 ccctgaccat tttcaaaata agccatcata acagcaaaat cttcctgctg ggctacaaaa
    24301 ttattggtac catcaatggg atcaatgacc caaaccttgc cctcttgaac cgaggctcgc
    24361 agacaacctt cttcagcaca aatcttatcc tcaggataac gagacaaaat ctcaccaacc
    24421 aagagttcct gaacttcttt gtccagtctg gtcaccaaat ctgttggaga ggacttggtt
    24481 tcaacacgca agtcttcctg catatggtca agaatgtact ggcctgcttt cttaacaagc
    24541 cctttagcaa attcaaattt actttccaag agaaatcttt ccttcccctt tttctttggc
    24601 agcctgaact gctcggtaaa gtgaatagcc actaaccgtt tcaaattctc gtcccaaacg
    24661 tttctcttcg ctcttgcttg gcacgaccgc tttgaatccc ttataggagt ccagtaactt
    24721 tttagcctct actttgcctt cataggcagc ttcaacatca ttaaaaaaag aaagcactga
    24781 agcaagttct tcagtgctcc acgacaaatc tagtgggtaa ctatactgtt tgttcattaa
    24841 ctaataccag ctctcattct tgcttctttt agttcttgct tacgataact acgagggaga
    24901 aaagcacgaa tctcatcttc attaaaaccg atttgcatac gcttggcatc aataataatt
    24961 ggacgacgca aaagactagg atactgctca atcaaatgaa gcaattccga taccgaaata
    25021 ctctctacat caatattcaa tttttgaaaa atttttgaac gagttgaaat gatgtcatca
    25081 gtaccatttt cggtcaagga aaggatgtgt tgcaattctt ttcttgttaa aggactggtc
    25141 ataatattgt gttccacaaa gggaacctta tgtttttcta accaggcctt agccttacga
    25201 catgatgtac agctcggtga tagaaatagt gtaatcatgc ttttctcttc ttatctatac
    25261 tttgctactt ctattataca aaaaaataag gcgcttgact agggattttt agaaaaaaag
    25321 cctatttttt caagaaaaat aggctttttg cgaacgattg acacaattgg atttggttaa
    25381 ttcactctta acgatggttt taaacgatat atatatttat atatgtaaat taaaaacatc
    25441 tttcctttca cttcctacga cttttcagat acagatagcc aaagaagttt tcatagaggg
    25501 caaaaaagag gaggaaggcg tgaagaaaga aggtctctgg caaaatcata ataacaggat
    25561 ccttggctgg atcaaaaagc caggtatcat ctcccacaaa gagaatttga tggaaaagag
    25621 taaagaattg gtcaaaacca atcaaaactc ccccaagtcc aatcatcaca ggtaagacta
    25681 ctagagccag gagacttttt cgataaagag acaaaaagtc ctttttcaca atcctattga
    25741 caaagacata gaaacttggc agtgtcacta gagctactag ctgaaccaaa tgaaagagat
    25801 tcttgaccac tgcgaaatgg tgcagaccag ctgctgacga acgaaaatca ggcatctgta
    25861 agacctgact aaaaggattg gtcagataat tcatcaagat atgaaaattg tattgaacgg
    25921 tttctggttt tagatagact cgattcgtta agtttagcca ctgaatctcc ataggataga
    25981 aaatccaagc cagataaatg gtcagaagga ttgagaggga gaggagaaag agcatagagc
    26041 cccaaaaggt caatttagtt ttcatcaaaa tcccactccg caaggctaga aaccacatgt
    26101 gtcggtgcga ttggcaggcc agctacttct tctgccttag taaaacctgt cgtcaccaag
    26161 agcgttggaa tgccattgtc aatcccagcc cggatatcag tcaaataatt gtccccaacc
    26221 atgattaact cttcacgttc caaacctaag tgctcaaccg ccttgtccat aatgatggca
    26281 tttggttttc cgatataaac cggcttcact cgtgtcgcta cttcaagcag cgtaatcagt
    26341 gagccagtac ctggcaaaag accacgttcc gtcgggatgt tgaggtcagg attggttccg
    26401 ataaaatggg cacccttttg aatagcaaga gttgctgtgg caaatttttc atagtcgact
    26461 tgccaatcca gaccaactac cacgtaggca gggttttcct tgtcttccac ataaccagcc
    26521 gccttgatgg cttccttgag tcctgcttct ccgacgacat agacagtctt ttcaagcccc
    26581 aaatcattca tatagtcgat ggttgccaaa gtcgctgtgt agacagtcga tagaggcgta
    26641 tcgatattaa aattctgagc caacatctcc ttaacactct ctggagtgcg ggttgtattg
    26701 ttggttacaa agagataggg aatgtcccgc ttttgcaatt catgaacaaa agtctctcca
    26761 gcagggattc ggtctttccc cttataaatg gttccgtcta aatcaattaa atagccttta
    26821 tatttcatct atttctccct aaaccttttt tatttcttgc caagtaatga ttgcttgggc
    26881 attgataacc ccatcacttg taatttcatg cttgctttcc agtccagtcc gttcaacagc
    26941 cgatgtaatc accccacctg gtcgaacttc cttgacatac ttgaggttga ttttcttggg
    27001 aatatagtgg gtcaaaaaat ccgctcccat gacctcaaaa atccagtcca agtatttact
    27061 gttattgaca tgaccattca tatccaagtc gtaaaaacga acatggtaat ccttgctgat
    27121 cggctcttcc aaggattcat acttcggtcc acggataagt tttttatcaa aatcagactg
    27181 gtaaggagcc acaatctcag gttcaacagc atggactttt cgactgtcgc ggtccatgag
    27241 aacaaaggtc gccatcatat ggatgagctc ctgccccgct tcattataaa tagtaaagcg
    27301 acggtagcaa aaaagtcgat tgtagctcaa ggcttccgtt tcgatggtaa tttcttccgc
    27361 aaaacgaggc aaacgaacca cctcaatatc atattctgcg ataatccaga ccagattata
    27421 gtcttccaaa atggccttat cactaactcc cagttcaatc gattgcatcc ctgaaacttg
    27481 cagtgacagc aaaatcacat ctggaagttt gatatgaccg ttcatatcag ccatatcaaa
    27541 aggaattttc attttcattt gataagttaa gcccatgatc ctactccaaa ataaatcgtt
    27601 ctgctacagt atctcccaaa aagagacctc tctttgtcat gcgaacgtgg tcaccctcaa
    27661 tctgcatgag gccttgttga accaaatctc tgacaatttc tccataaagt ccagcaaaag
    27721 actgtccaaa tttttcctca aatcgcgcca tggaaacccc ggatttcttg cggagtccca
    27781 agaacatttc ttcttccatt tgctcctttt gactcaggtg atcttctgta atacaagcat
    27841 tgccttcctc aaccgcactg agataatgac gaatgggacc atgattttta tagcgtactc
    27901 cattgacata accagatgcc cctgcaccaa taccatagta ttcagcattg tcccagtaca
    27961 tgagattatg acgactttca aagccgggtt tggagaaatt agaaatctca taatgctcaa
    28021 aacccgctcg ctccagctct gcaatgatgt actcaaacat ctccgcttct agttcctcct
    28081 taggcagagg caatttccca cgtcgcatcc ggttcataaa gaccgtatgg ttttctaaaa
    28141 tcaaactata caaactcatg tggggaatat ccaatccaat ggctttagcc acattttcct
    28201 ttacttgctc catggtctga ccaggcagag cataaatcaa atcaatggag atgttgtcaa
    28261 aaccagccag tttcaggcga tcgatatttt cataaatatc cttctccaaa tgactgcgcc
    28321 caatcttttt caacatctta tcatcaaagg tctggacacc tagcgaaaca cgattgacag
    28381 ccgaattttt caaaacagct atcttatccg catccaaatc gcctggattg gcttcaatgg
    28441 tcaactcttc caagacagac aaatccaagt ttttagtcaa gccattcagt aacacctcca
    28501 gttgcggagc cgacagggct gtcggtgttc caccaccgat ataaagggtt gacaactttt
    28561 caatatcata agaacgaaac tcttccagca gatgctctaa atagctgtcg actggctgat
    28621 ttttgatgaa gacctttgaa aaatcacaat aataacaaat ctgggtacaa aatgggatgt
    28681 gcacataggc tgacgttggt tttttctgca tagtaattat tataccacaa agactagatt
    28741 ccagataaaa atcaccatcc ccagatacat agtccgtccg gagatggtga tggtttattc
    28801 ttctgttata tcaatcacaa tctcttctga gtcatcaaga gcttcggctt tttcttgcca
    28861 ttgttccttg agattattta attgattttt tgatgcttct gtcgcttgaa aagcatagga
    28921 tttagcttga gcaagtatac tgtccacagt gatttcacct gactcaacct gttcttttgt
    28981 tttcagaaca aaatctgtag cctgctcctt aacttctgtc agtttttcac agacttgctc
    29041 cttggcatac tccggatctt ctctcaaatc atctagaaaa tcttgagcct gactgcaaac
    29101 ttgtttgccc ttatcacttg ttaaaaacaa ggcaagagct gcacctgaaa cggttcctaa
    29161 aaggattgag gataatttac ccataaggat tctccttttt tattttttga aaaatttact
    29221 tgcaagacga agagctgaca gacttgcacc agtcttgagt gtttttgaac cagctgatga
    29281 agctttcttg ctcaagacac gcgcatggtc attgaggtct gaaacagata gagataaatc
    29341 tgcaacagca ctgaagagtg gatcaatcgt agccaccttg acattgatat catctgccaa
    29401 gacattgacc ttagccaaca actcattggt gtgatgcaag gtcacatcca catctgaagt
    29461 caaggtttta atcgtctttt ctgtttcatc gatgacacga ccaagctttt gtacagtaat
    29521 gatcagatag accaaaaaga caatcacagc tagggcaaca agaatatatg caacttctaa
    29581 catttagttt tcctcctctg taatatagta aggggccttc tttcgatttt gataaataac
    29641 gatcattata ccgagaccga taaagacaac tgacagccat tgggacactc gaaggccgaa
    29701 gaacatgaga ctatctgttc gcataccttc gatgaccata cgaccgaaac cataccaaat
    29761 caagtaaaag gccgtgatat gacctcgtct gagactcttc catttccgtc taaaaatcag
    29821 aatcaaggca aagccaagca gattccatag agactcataa aggaaagtcg gttgacggta
    29881 gctcccctca atatacatct ggtcacggat aaagccaggt agataatcca gattatccac
    29941 tgttgcacca taagcttctt ggttaaagaa attaccccaa cgccccaaac tttgagcaat
    30001 cataacgcta ggcgccgcaa tatctagaaa atcccaagta ttgatgagtt tacggtcagc
    30061 aaagatatag agcacaagag ccccagttat caaaccaccg taaatggcca aaccaccatt
    30121 ccaaatggca aaaatctctc ctaaattctg actatagtaa tcaaatcgga aaataacata
    30181 gtagagacga gctcctaaaa tagccaaggg aaaggctact aagataaaat ctaaaatatc
    30241 gtctggtatg atcttctttc taggtgcttc tttcatggtc aaataaaccg caagaatcaa
    30301 gcctgtcaca atacataagg cataccaacg aatggctagg ggtcctagtt gaatagcaat
    30361 tggatcaagc attttgcacc tcatttcgag ctatgagact tgtcagtcgt tcgtcgaaca
    30421 aacgggtagc atcaaagccc atttccttgg cacgataatt catggcagct gcctcaatca
    30481 caacagagat attacgacct gttttaactg gaatacgaat acgaggaatg gctacgccag
    30541 aaacttcaag ttcctctgca ttgtttccaa gacgatcaaa ggtcttatgc gtatcgtaat
    30601 tttccaaata gacagcaagc tgaacctgtg aagaatcctt gacagcactc gcaccgtaga
    30661 gactcataac atcgataata ccaaccccac gaatttcaat caagtgtttc aaaatttcag
    30721 ctggttcacc ccagagagta atctcatcct tggcaaagat atcgacacgg tcatcggcta
    30781 ccaaacggtg accacgtttg acaagctcaa gacctgtctc gctcttacca attccactat
    30841 ctccctgaat caagacgccc atcccataaa tatccatcaa gacaccgtgc acactggtac
    30901 gttctgccaa acgagaatcc agatagctag ataactctcc agataaacga ctggtagctg
    30961 cacggctggt taaaatagca atcttacatt ctctagcagc ctttaacatc tcctctggaa
    31021 ccaccaaacc acgggcaaca atgactgctg gtgtctcagg tagaaacatt tttttcaaaa
    31081 cttcataacg gctgttggaa ggcatgctga tcagataaga ccactccttc atccccaaaa
    31141 gttgaatccg ctctggtgta tagtagtcaa aatagcctgt catttcaaga ccaggtcgcg
    31201 taatatccgc tgtattgatt tccttttcaa gcaattctgg ttcaccatag acaatatcta
    31261 gtctaagctt ttcaatcact tcttttacta aaaccgacat catttcctcc ttcaaatgaa
    31321 ttcttctctc tattatatca aattgtagga ggaagtttca gatttttgca ggctttggag
    31381 tatttattta aaagaaaaag gactagattt ctctagcctt tcatttcaat tagaattttt
    31441 tacgtttacg agctacttct gatttacgtt tacgttttac agaaggtttt tcatagaatt
    31501 cacgtttgcg tgtttcttga agagtaccag ctttagtaac cgcacgtttg aaacggcgaa
    31561 gtgcgtcgtc aagagattca ttcttacgta ctactgtttt agacattttt ttcactccct
    31621 tcaagttcaa tatctatttc attctacacg taaaaggaat aattgtcaag caaaaatgcg
    31681 gtttaatttt gattttttct tccatttata caagagttga aagcgttcaa tagaacattg
    31741 cttttttatt tttcgagtaa gctaagcgct tcagcatctg cgatgatggt tacatcaggg
    31801 tgattttgga ggctactcgc aggtaggttc tcagtcactg ggccagatac tgttccggca
    31861 atggcttctg ctttcgactc accataagca aaaagaataa tagacttggc atccaaaatg
    31921 tttttaatcc ccattgaaat agcttgggtt gggacgtctt caatcttggc aaagaagcga
    31981 gcattggctt cgatagtaga ctggtcaagt tctactagat gcgtttgact gtcaaatgga
    32041 gtaccaggct cattaaagcc gatatgccca ttgcgaccga ttcccaagat ttggaggtca
    32101 actggatggt cagccaaaat ttggttgtag cgttcaactt cagcttcagc attgtcctta
    32161 acaccacgag gcaagaaact ttctttaaat ggtttttggt tgaacaagtt ttcttgcatg
    32221 aagtaacgat aagactgtgg attgtcccca tcaaggccca catactcatc aaggttgaca
    32281 ctggttagat ttgaaaaatc aaggtcactc tcaacaattt ccttgtaaaa ttcaagtggg
    32341 ctacttcctg tcgcaagtcc tagagtttga gctccattag ccaatttttc cttcaaaatc
    32401 tcaaaagcaa cttttccacc ttgaacttgg ttttcaactt taataacttt catcttttca
    32461 tcctccattt ctgtctatat ttattatatg gtatagacca atttttgtca agtgaaaacg
    32521 atttaatttc taaaaaaaga gcgtccaaac ttgaaacgtg ttataatgga taggattaga
    32581 acttagaaag aatgaacaga tatatgaata cagctgattt tgatttccac ttgccagagg
    32641 aattgattgc ccaaacgccc cttgaaaaac gtgatgcctc caaactcctc atcgtcaacc
    32701 gtgagacagg agaaatgcaa gataaacact tccactctat tattgatatg ctggaacctg
    32761 gtgatgccct tgtcatgaac gacacccgag ttctccctgc ccgcctctat ggtcaaaaag
    32821 tggagacagg aggtcatgtg gaacttctcc tccttaagaa cactagtgga gacgagtggg
    32881 aagttctggc taaacctgcc aaacgcctca aggtcggtac tcgtatcagc tttggtgatg
    32941 gccgcctcag cgctgtcgtt acagaagaat tgacccacgg gggacgcatt gtccgctttg
    33001 aataccaagg aattttccta gaagtcttgg aaagtctggg agaaatgcct ctgccacctt
    33061 atatccacga aaaattagat gaccgtgaac gttatcaaac cgtctacgcc aaggaaagcg
    33121 gctctgctgc agcaccgact gctggtcttc acttcaccaa agaactgctg gcagaaatcc
    33181 aagctaaggg tgttcatcta gtctatctga ctctccatgt cggactcgga acctttagac
    33241 ctgtttctgt ggataatctg gacgaacacg aaatgcactc agagttctat caactttctg
    33301 aggaagctgc tgccaccctt cgctctgtca aaaaaaatgg tggtcgtgtc atcgctgtcg
    33361 gaaccacttc tatccgcacc ttggaaacta ttggttccaa gtttgatggg caaatccaag
    33421 cagattctgg ttggaccaat atctttatca aacctgggta tgagtggaag gtcgtggatg
    33481 ccttctcaac caacttccac ctgccaaaat caactctggt catgttggtt tctgcctttg
    33541 caggccgtga attagtctta gatgcctacc accattccat ccaagaacac taccgcttct
    33601 tcagttttgg tgacgccatg tttatttatt gagaaagaat ttctctaaat cttctaatac
    33661 caataaatcg ctaagatatt atttcaaaga acatctacaa ttgaaactct agctagctgt
    33721 agaagaggcc tagtacattg aaattaaaat gcttccccct agcttcgaaa atattgccat
    33781 agattgcgtt gactctccaa attgattcat ctatatttta tttcagcttc ctatattttc
    33841 ttcgctgttt gtaaatcaaa atgcaagaca catgagtagc accatatttg ttactcttat
    33901 ctgtcctctc aagagactat tatgagttat ttcagaatca ttcactactt tgaccctgac
    33961 tctccttagt ctcaaaatca aagacttata ctcttcaaaa atctcttcaa accgcgtcaa
    34021 cgtcaccttg gattatatat gtgactgact tcgtcagttc tatctacaac ctcaaagcag
    34081 tactttgagc aacctgcgac tagttttcta gtttgctctt tgattttcat tgagtattaa
    34141 acaaaaagtg aacaaatctg aattctaatg tacagaagac taggcttgtt cactttttta
    34201 tagtcgctat aagatgacct tatctatagc ttttt
//
LOCUS       DAVHIZ010000020        33883 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.020, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000020 DAVHIZ010000000
VERSION     DAVHIZ010000020.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 33883)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 33883)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..33883
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.020"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(103..1326)
                     /locus_tag="VVO18_000973"
     CDS             complement(103..1326)
                     /locus_tag="VVO18_000973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000628995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family transcriptional regulator"
                     /protein_id="HEU5586151.1"
                     /translation="MITKQSAFLQNRATILEFLYRNPATSRTDIVNETGLTPATTTNI
                     IKELSEQSLIYETGDEFSEFSGSGRRRKTISITDNIPYVVGGIEINVLGIFLSLCDLQ
                     GKTLFETEILNEDYPISEINSTITNMIKTAIEYVPLETKLLGFGLSIPGHYNKDSGSI
                     ITNNPIWESFNLLNVIKRFNFPFIVKNNIDCMAIGQYLFNPHNTPDNFIFLHAGLGIY
                     TSFFTKEKIGASKNPYIGEIGHTIVELNGQYCECGKKGCLQTYISDAWLIKHAQLLFK
                     NSQLTVLKSLVKTEKDIHLDTLLTAYNLGDSALRQQIDKGVNLLATSIANLLLINPAD
                     KIYINSQLLNYQPFTHEVRDKIQDQLHFVPFTRNIEIEILPYNKHRGSIGACALAIVA
                     FFIEHSNVLQDIISP"
     gene            1493..2815
                     /locus_tag="VVO18_000974"
     CDS             1493..2815
                     /locus_tag="VVO18_000974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU5586152.1"
                     /translation="MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSL
                     FLILISWPQEDFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPS
                     AGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAE
                     IYRMFIQRGITIKMPSGVPDVVSKSFSALLPGFTTFVLWALVLKGLEAAGVAGGLNGL
                     LGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEA
                     VAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFN
                     INTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIG
                     GFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK"
     gene            2817..4703
                     /locus_tag="VVO18_000975"
     CDS             2817..4703
                     /locus_tag="VVO18_000975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000236922.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4838 domain-containing protein"
                     /protein_id="HEU5586153.1"
                     /translation="MVIRVFDQQKNTYSSFALEELSYYMNRVFKTNIELVEEKEADIF
                     VGLVNKEDRKDHVLISLDKGKGRIESNTIVGLLIGIYRMFHEFGVVYTRPGRGHDFVP
                     ELRFEDFLDKQLSIDETASYYHRGVCIEGADSFENILDFIDWLPKIGMNSFFIQFENP
                     YSFLKRWYEHEFNPYLNKEQFSNELVQELSDRLDKELQKRGLIHHRVGHGWTGEVLGY
                     SSKFGWESGLSISEEKKPYVAEINGKRELFNTAPILTSLDFSNPDVADKMVEIIKDYA
                     KKRPDVNYLHVWLSDARNNICECENCRQELVSDQYIRILNQLDRALTSEGLDTKICFL
                     LYHELLWAPQKEKLDNPERFTMMFAPITRTFEMSYADVDFDNSIPTPKPYMRNKIILP
                     NSLEENLSYLFEWQKAFKGDSFVYDYPLGRAHYGDLGYMKISQTIYRDVSYLSNLHLN
                     GYISCQELRAGFPHNFPNYVMGQMLWKKTRSYEELIEEYFSALYGENWQSVVEYLEKL
                     SIYSSCDYFNAIGSRQNDVLANHYYIAYNLADNFLPIIEENISKLLNSQKDEWKQLSY
                     HREYVVKMAKALYLQATGKTRQAQDEWRNVLNYIRGHELLFQSNLDVYRVIEVAKNYA
                     GFHL"
     gene            4871..5215
                     /locus_tag="VVO18_000976"
     CDS             4871..5215
                     /locus_tag="VVO18_000976"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU5586154.1"
                     /translation="MKSKEEINMLGFTIVAYAGDARSDLMDALAFARDGYFEQARELV
                     ESANDSIVSAHREQTNLLAEEAYGDNFEVSFIMIHGQDTLMTTMLLYDQVKFFIDEYE
                     RIRKIEEHIGLQ"
     gene            5225..6637
                     /gene="lacG"
                     /locus_tag="VVO18_000977"
     CDS             5225..6637
                     /gene="lacG"
                     /locus_tag="VVO18_000977"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEU5586155.1"
                     /translation="MENLQFKVLPKEFLLGAATAAYQVEGATRVDGKGINMWDVYLQE
                     NSPFLPDPASDFYYRYEEDIALAAEHGLQALRLSISWVRIFPDIDGDANVLAVHYYHR
                     VFQSCLKHNVIPFVSLHHFDSPQKMLETGDWLNRENIDRFIRYARFCFQEFTEVKHWF
                     TINELMSLAAGQYIGGQFPPNHHFQLSEAIQANHNMLLAHALAVLEFHQLGIEGKVGC
                     IHALKLGYPIDGQKENILAAKRYDVYNNKFLLDGTFLGYYSEDTLFHLNQILEANNSS
                     FIIEDGDLEIMKRAAALNTMFGMNYYRSEFIREYKGENRQEFNSTGIKGQSSFKLNAL
                     GEFVKKPGIPTTDWDWNIYPQGLFDMLLRIKEEYPQHPVIYLTENGTALKEVKPEGEN
                     DIIDDSKRIRYIEQHLHKVLEARDRGVNIQGYFIWSLQDQFSWANGYNKRYGLFFVDY
                     ETQKRYIKKSALWVKGLKRN"
     gene            6706..8385
                     /locus_tag="VVO18_000978"
     CDS             6706..8385
                     /locus_tag="VVO18_000978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU5586156.1"
                     /translation="MDKLVAAIEKQQGKFEKISTNNYMMAIKDGFIATMPLIMFSSFL
                     MIIIMIPKNFGVELPSPAIVWMRKVYMLTMGVLGVIVSGTVAKSLAGNVNRKMPPGKV
                     INDISVMLAAICSYLVLTVTLVVDEKTGSTSLSTNYLGSQGLVTSFVSAFITVNVYRF
                     CIKRDITIHLPKEVPGAISQAFRDIFPFSFVLLISGLLDIVSRFSLDVPFAQVFQQLL
                     TPIFKGVESYPAMMLIWFMCALLWFVGIHGPSIVLPAVTALQLSNMEENAQLLANGQF
                     PYHSLTPNFGNYIAAIGGTGATFVVPFILIFFMRSKQLKSVGKATITPVLFAVNEPLL
                     FGMPVILNPYLFVPFLMTPPVNVFLGKVFIDFFGMNGFYIQLPWAFPGPLGLLIGTNF
                     QSISFVFLSLMLVVDILIYLPFCRAYDRQLLMKEDVVSSNDIILEEETSEIMPGEIDV
                     IKSKELKVLVLCAGSGTSAQLANAINEGAQLAEVRVIANSGAYGAHYDIMGVYDLIIL
                     APQVRSYYREMKVDAERLGIQIVATRGMEYIHLTKSPSKALQFVLEHYQAV"
     gene            complement(8511..9950)
                     /locus_tag="VVO18_000979"
     CDS             complement(8511..9950)
                     /locus_tag="VVO18_000979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrkH family potassium uptake protein"
                     /protein_id="HEU5586157.1"
                     /translation="MNKSMIRYLLSKLLLIEAVLLLVPVAIAVYYRESSQVFTALFST
                     IGILVLLGGSGSLQKPKNQRIYAKEGVLIVALCWILWSFFGGLPFVFSGQIPSLIDAF
                     FEISSGFTTTGASILNDVSVLSRSLLFWRSFTHLIGGMGVLVFALAIMDNAKNSHLEV
                     MKAEVPGPVFGKVVSKLKNTAQILYLLYLALFSLFVIIYYLAGMPLYDSFVIAMGTAG
                     TGGFTVYNDGIAHYGSSLITYLVSIGVLVFGVNFNLYYYLMLRRIKAFFGDEELRAYL
                     VIVLVSTGLISLNTLYLYPGFSKSFEMTFFQVSNIITTTGFGYGDITNWPLFSQFILL
                     FLMAIGGSAGSTAGGLKIIRGLILSKIAKNQILSILSPHRVLTLHVNKTVIDKDTQHK
                     ILKYFVIYAMILLALIFIVSLDSNDFLVVTSAVFSCFNNIGPILGTTSSFSIFSPISK
                     ILLSFAMIAGRLEIYPILLLFMKRTWSKR"
     gene            complement(9954..11303)
                     /gene="trkA"
                     /locus_tag="VVO18_000980"
     CDS             complement(9954..11303)
                     /gene="trkA"
                     /locus_tag="VVO18_000980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Trk system potassium transporter TrkA"
                     /protein_id="HEU5586158.1"
                     /translation="MKIILVGGGKVGFALCRSLVAEKHDVLLIEQDEAVLNHIVSRFD
                     IIGILGNGADFAILEQASVQDCDIFIALTEHDEVNMIAAVLAKKMGAKETIVRVRNPE
                     YSNSYFKEKNILGFSLIVNPELLAARAIANIIDFPNALSVERFAGGRVSLMEFVVKST
                     SGLCQMPISDFRKKFGNVIVCAIERDHQIIIPSGDMTVQDKDRIFVTGNRVDMILFHN
                     YFKSRAVKSLLIVGAGRIAYYLLGILKDSRIDTKVIEINPEIASFFSEKFPNLYIVQG
                     DGTAKDILLEESAQHYDAVATLTGVDEENLITSMFLDRVGVQKNITKVNRTSLLEIIN
                     APDFSSIITPKSIAVDTIMHFIRGRVNAQYSDLQAMHHLANGQIETLQFHIKEANKMT
                     AKPLSQLKLKKGVLIAAIIRKGKTIFPTGEDMLEVGDKLLVTTLLPNITKIYDLIAR"
     gene            11491..12339
                     /locus_tag="VVO18_000981"
     CDS             11491..12339
                     /locus_tag="VVO18_000981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862942.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S-adenosyl-l-methionine hydroxide
                     adenosyltransferase family protein"
                     /protein_id="HEU5586159.1"
                     /translation="MNNNLLVLQSDFGLVDGAVSAMIGVALEESPTLKIHHLTHDITP
                     YNIFEGSYRLFQTVDYWPEGTTFVSVVDPGVGSKRKSVVAKTAKNQYIVTPDNGTLSF
                     IKKHVGIVAIREISEVANRRQNTEHSYTFHGRDVYAYTGAKLASGHITFEEVGPELSV
                     EQIVELPVVATIIEDHLVKGAIDILDVRFGSLWTSITREEFYKLEPEFGDRFEVTIYH
                     ADMLVYQNQVVYGKSFADVRIGQPILYINSLYRLGLAINQGSFAKAYNVGVGSSWTIE
                     IKKIEG"
     gene            12354..12902
                     /locus_tag="VVO18_000982"
     CDS             12354..12902
                     /locus_tag="VVO18_000982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF-type riboflavin transporter
                     substrate-binding protein"
                     /protein_id="HEU5586160.1"
                     /translation="MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQ
                     ALLSIIFGPIIGLLVGLIGHAIKDSLVGYGLWWTWIIASGLFGLVVGLFRKYVRVING
                     VFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAI
                     AGTLLLLAYAGTQTRAGSLKKD"
     gene            12909..13166
                     /locus_tag="VVO18_000983"
     CDS             12909..13166
                     /locus_tag="VVO18_000983"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586161.1"
                     /translation="MKIKEQTRKLAAGCSKQCFEIVDRTDEVSSKHGFEVVDETDEVS
                     NHTYGKAKLTWFEEIFEEYKMMGKAGQLVFFDVYRLVRQVS"
     gene            13268..14950
                     /locus_tag="VVO18_000984"
     CDS             13268..14950
                     /locus_tag="VVO18_000984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000656554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586162.1"
                     /translation="MKEAIIEWKDFSFRYETQQEPTLQGIDLTIYKGEKVLIVGPSGS
                     GKSTLGQCLNGIIPNIYKGQTYGEFLIKGQAAFDMSIYDKSHLVSTVLQDTDGQFIGL
                     SVAEDLAFALENDVTALDEMKGRVYKWAEKLDLLPLLDQRPQDLSGGQKQRVSLAGVL
                     IDESPILLFDEPLANLDPKSGQDIIELIDQIHKEEGTTTLIIEHRLEDVLHRPVDRIV
                     LINDGRILFNGSPDQLLATDLLTQNGIREPLYLTTLRQLGVDLVKEEQLANLDNLSIS
                     KGQVQLQNELAKETPALQSLFRLEEVSFSYDDRPILKSLHLDIKKGEKIAIVGKNGAG
                     KSTLAKAISSFIQTEGRYLWEKQDIKGDSVAERAERVGYVLQNPNQMISTNMIFDEVA
                     LGLRLRGVDEKEIETRVYETLKICGLYEFRNWPISALSFGQKKRVTIASILVLGAEII
                     LLDEPTAGQDQKNYTEIMEFLEELHQKGHTIVMITHDMQLMLDYSDRVLVMVDGELIA
                     DTVPASLLSDPELLVKANLKETSIFNLAKKLDVDPLDLTAFYKERREGCKLN"
     gene            14935..15765
                     /locus_tag="VVO18_000985"
     CDS             14935..15765
                     /locus_tag="VVO18_000985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU5586163.1"
                     /translation="MQAKLIGYQHRDTVIHRLSGAGKLLFFILVSLAAMISYDTRMLL
                     LIAIFSVFLLYLSEIRFKDVSFVAVFATVFAVLNVLMVYLFSPEYGVGLYGERSVIWQ
                     GIGVYTLTSQELFYLLNLAIKYLCTIPLAIIFLMTTHPSQFASSLNQIGVPYKIAYSV
                     SLTLRYIPDLQEEFFTIKMSQEARGMELSKKASLMQRIKGNLLIITPLIFSSLERIDT
                     IATAMELRRFGKEKKRTWYSYQALKKGDYITLLLATLFLVVSLLLILQNQGRFYNPWK
                     "
     gene            15958..16461
                     /locus_tag="VVO18_000986"
     CDS             15958..16461
                     /locus_tag="VVO18_000986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000181367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (cytidine(34)-2'-O)-methyltransferase"
                     /protein_id="HEU5586164.1"
                     /translation="MTNHIVLFEPQIPQNTGNIARTCAATNSPLHIIKPMGFPIDDRK
                     MKRAGLDYWDKLEIYFYESLEDFMSQMKGKLYLISKFAEKIYSEVDLSTDEDHYFLFG
                     REDKGLPEDFMREHPEKALRIPMNDEHVRSLNVSNTVCMIVYEALRQQNFAGLELVHT
                     YEVDKLK"
     regulatory      16515..16749
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
     gene            16914..17477
                     /locus_tag="VVO18_000987"
     CDS             16914..17477
                     /locus_tag="VVO18_000987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU5586165.1"
                     /translation="MTNTRRLSTIAILSAISFVLMYFDFPLLPAASFLKIEFSILPVL
                     VGLVVMDLPAALGVLLLRSLLKLLLNSQGVNTYIGLPMNIVALGVFVIVFALIWKKER
                     TTLRFLLGSLAGTVGLTLAMLVLNYVYAVPLYAKFANFDIGKILGLSNYLMTMVLPFN
                     LIEGVIFSVSFWLLYVLLKPTLKHYER"
     gene            17491..18117
                     /locus_tag="VVO18_000988"
     CDS             17491..18117
                     /locus_tag="VVO18_000988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEU5586166.1"
                     /translation="MKGSFALLLFVILGYMVKFYPETLVGFDQSIQTAIRGDLPDYLT
                     ILFRSLTRLIDIPVIITWVVIIAFVFYRKRWKIESFFMLGNLALAGLLIVTFKNIYQR
                     PRPAILHLVEEKGFSFPSGHSLAVTLMVGTLIVILSQRIKDQVWRKIVQIVLGLYLVS
                     VLVSRVYLGVHYPSDVLASLCVGLGVLFIEFPFYDKLRFQWRFKGKQK"
     gene            18144..18533
                     /locus_tag="VVO18_000989"
     CDS             18144..18533
                     /locus_tag="VVO18_000989"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000867286.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome partitioning protein ParB"
                     /protein_id="HEU5586167.1"
                     /translation="MKVNIADLHPTQLYLSEKKLQDIQMLYQSAETIQVDPISILAFG
                     DCLLITDGHHRAYQALLAGRDTISAEWDRGGGDELYHLYAQACEERKIYSVFDLEDRI
                     LAQDGYEAKWYNWCDGFNQAATLLLKR"
     gene            18538..18987
                     /locus_tag="VVO18_000990"
     CDS             18538..18987
                     /locus_tag="VVO18_000990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000333655.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586168.1"
                     /translation="MCFVPYYKVNYCEEAFAWYQDVNLVYLVDGVKLPYSQATLEAMY
                     SYLDRHGELFWIEVKEKGEWFPIGDITLSQDNLPIVIGNSAYQHRGLGKKILSALIEL
                     ARVKGWKELRVKEIYTYNHASRRCFKSLGFVENGATEKGRSFILELV"
     gene            19115..19702
                     /locus_tag="VVO18_000991"
     CDS             19115..19702
                     /locus_tag="VVO18_000991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418402.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="HEU5586169.1"
                     /translation="MELEVFAGQEKSELSMIEVARAILELRGRDHEMHFSDLVNEIQN
                     YLGTSNSDIREALPLFYTELNFDGSFISLGDNKWGLRSWYGVDEIDEEIIALEENDDD
                     EVAPKAKKKRVNAFMDGDSDAIDYNADDPEDEDAYEADPALSYDDENPDDEKNEVEAY
                     DAEINEIAPDDLGEDVDLNEDDDEFSDDDAETSEE"
     gene            20092..21699
                     /locus_tag="VVO18_000992"
     CDS             20092..21699
                     /locus_tag="VVO18_000992"
                     /EC_number="6.3.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105234.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CTP synthase"
                     /protein_id="HEU5586170.1"
                     /translation="MSTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPY
                     INIDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRK
                     ERRGEYLGATVQVIPHITDALKEKIKRAALTTDSDVIITEVGGTVGDIESLPFLEALR
                     QMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPA
                     GQGIKNKLAQFCDVAPEAVIESLDVEHLYQIPLNLQAQGMDQIVCDHLKLDAPAADMT
                     EWSAMVDKVMNLKKQVKISLVGKYVELQDAYISVVEALKHSGYVNDVEVKINWVNAND
                     VTAENVAELLSDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGVCLGMQLTCIEF
                     ARHVLGLEGANSAELAPETKYPIIDIMRDQIDIEDMGGTLRLGLYPSKLKRGSKAAAA
                     YHNQEVVQRRHRHRYEFNNAFREQFEAAGFVFSGVSPDNRLVEIVEIPENKFFVACQY
                     HPELSSRPNRPEELYTAFVTAAVENSN"
     gene            complement(22258..23889)
                     /locus_tag="VVO18_000993"
     CDS             complement(22258..23889)
                     /locus_tag="VVO18_000993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004251733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Na/Pi cotransporter family protein"
                     /protein_id="HEU5586171.1"
                     /translation="MSINWQEILFHFLGGLGLFLYSIKTMGDGLQQAAGDRLRFYIDK
                     YTSNPFFGVLVGIGMTALIQSSSGVTVITVGLVSAGLLTLRQAIGIVMGANIGTTVTS
                     FLIGFKLGNYALPMLFIGAVCLFFTKNRTVNNIGRILFGIGGIFFALNLMSGAMAPLK
                     DLQVFKDYMIELSKNPVLGVFVGTGLTLLIQASSATIGILQNLYAGNLIDLQGALPVL
                     FGDNIGTTITAIIASLGANIAAKRVAGAHVAFNVIGTVVCVIFLVPFTVLIHWFEATL
                     NLAPEMTIAFAHGTFNITNTIVQFPFIGALAYFVTKIIPGEDEVVKYEPLYLDEHFIK
                     QAPSIALGNAKKELLHLGNYAAKAFDLSYKYIIGLDEKVAEKGHKTEEAINTIDEQLT
                     RYLIALSSEALSQKESEVLTNILDSSRDLERIGDHTEALLNLTDYLQRKNVEFSDAAL
                     KELEEVYRQTSDFIKDALDSVENNDIEKARSLVERHEAINKIERVLRKTHIKRLNKGE
                     CSTQAGVNFIDIISHYTRVSDHAMNLAEKVFAEQI"
     gene            24178..29118
                     /locus_tag="VVO18_000994"
     CDS             24178..29118
                     /locus_tag="VVO18_000994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000795197.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacterial Ig-like domain-containing protein"
                     /protein_id="HEU5586172.1"
                     /translation="MKNPFFERRCRYSIRKLSVGACSLMIGAVLFAGPALAEETAVPE
                     NSGANTELVSGESEHSTNEADKQNEGEHTRENKLEKAEGVATASETAEAASAAKPEEK
                     ASEVVAETPSAEAKPKSDKETEAKPEATNQGDESKPAAEANKTEKEVQPDVPKNTEKT
                     LKPKEIKFNSWEELLKWEPGAREDDAINRGSVVLASRRTGHLVNEKASKEAKVQALSN
                     TNSKAKDHASVGGEEFKAYAFDYWQYLDSMVFWEGLVPTPDVIDAGHRNGVPVYGTLF
                     FNWSNSIADQERFAEALKQDADGSFPIARKLVDMAKYYGYDGYFINQETTGDLVKPLG
                     EKMRQFMLYSKEYAAKVNHPIKYSWYDAMTYNYGRYHQDGLGEYNYQFMQPEGDKVPA
                     DNFFANFNWDKAKNDYTIATANWIGRNPYDVFAGLELQQGGSYKTKVKWNDILDENGK
                     LRLSLGLFAPDTITSLGKTGEDYHKNEDIFFTGYQGDPTGQKPGDKDWYGIANLVADR
                     TPAVGNTFTTSFNTGHGKKWFVDGKVSKDSEWNYRSVSGVLPTWRWWQTSTGEKLRAE
                     YDFTDAYNGGNSLKFSGDVAGKTDQDVRLYSTKLEVTEKTKLRVAHKGGKGSKVYMAF
                     STTPDYKFDDADAWKELTLSDNWTNEEFDLSSLAGKTIYAVKLFFEHEGAVKDYQFNL
                     GQLTISDNHQEPQSPTSFSVVKQSLKNAQEAEAVVQFKGNKDADFYEVYEKDGDSWKL
                     LTGSSSTTIYLPKVSRSASAQGTTQELKVVAVGKNGVRSEAATTTFDWGMTVKDTSLP
                     KPLAENIVPGATVIDSTFPKTEGGEGIEGMLNGTITSLSDKWSSAQLSGSVDIRLTKP
                     RTVVRWVMDHAGAGGESVNDGLMNTKDFDLYYKDADGEWKLAKEVRGNKAHVTDITLD
                     KPITAQDWRLNVVTSDNGTPWKAIRIYNWKMYEKLDTESVNIPMAKAAARSLGNNKVQ
                     VGFADVPAGATITVYDNPNSQTPLATLKSEVGGDLASAPLDLTNQSGLLYYRTQLPGK
                     EISNVLAVSVPKDDRRIKSVSLETGPKKTSYAEGEDLDLRGGVLRVQYEGGTEDELIR
                     LTHAGVSVSGFDTHHKGEQNLTLQYLGQPVNANLSVTVTGQDEASPKTILGIEVSQEP
                     KKDYLVGDSLDLSEGRFAVAYSNDTMEEHSFTDEGVEISGYDAQKTGRQTLTLRYQGH
                     EVNFDVLVSPKAALNDEYLKQKLAEVEAAKNKVVYNFASPEVKEAFLKAIEAAEQVLK
                     DHETSTQDQVNDRLNKLTEAHKALNGQEKFKEEKTELDRLTGEVQELLAAKPNHPSGS
                     ALAPLLEKNKALVEKVDLSPEELATAKQSLKDLVALLKEDKPAVFSDSKTGVEVHFSN
                     KEKTVIKGLKVERVQASAEEKKYFAGEDAHVFEIEGLDEKGQDVDLSYASIVKIPIEK
                     DKKVKKVFFLPEGKEAVELAFEQTDSHVIFTAPHFTHYAFVYESAEKPQPAKPAPQNK
                     VLPKPTYQPASDQQKAPKLEVQEEKVAFHRQEHENTEMLVGEQRVIIQGRDGLLRHVF
                     EVDENGQRRLRSTEVIQEAIPEIVEIGTKVKTVPAVVATQEKPAQNTAVKSEEASKQL
                     PNTGTADANEALIAGLASLGLASLALTLRRKREDKD"
     gene            29208..30404
                     /locus_tag="VVO18_000995"
     CDS             29208..30404
                     /locus_tag="VVO18_000995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate kinase"
                     /protein_id="HEU5586173.1"
                     /translation="MAKLTVKDVDLKGKKVLVRVDFNVPLKDGVITNDNRITAALPTI
                     KYIIEQGGRAILFSHLGRVKEEADKAGKSLAPVAADLAAKLGQDVVFPGVTRGAELEA
                     AINALEDGQVLLVENTRYEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHA
                     SNVGISANVEKAVAGFLLENEIAYIQEAVETPERPFVAILGGSKVSDKIGVIENLLEK
                     ADKVLIGGGMTYTFYKAQGIEIGNSLVEEDKLDVAKALLEKANGKLILPVDSKEANAF
                     AGYTEVRDTEGEAVSEGFLGLDIGPKSIAKFDEALTGAKTVVWNGPMGVFENPDFQAG
                     TIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGL
                     AALTEK"
     gene            30540..31067
                     /locus_tag="VVO18_000996"
     CDS             30540..31067
                     /locus_tag="VVO18_000996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEU5586174.1"
                     /translation="MSYFKKYKFDKSQFKLGMRTFKTGIAVFLVLLIFGFFGWKGLQI
                     GALTAVFSLRESFDESVHFGTSRILGNSIGGLYALVFFLLNTFFHEAFWVTLVVVPIC
                     TMLTIMTNVAMNNKAGVIGGVAAMLIITLSIPSGETILYVFVRVLETFMGVFVAIIVN
                     YDIDRIRLFLEKKEK"
     gene            31144..31500
                     /gene="glnR"
                     /locus_tag="VVO18_000997"
     CDS             31144..31500
                     /gene="glnR"
                     /locus_tag="VVO18_000997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000659547.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor GlnR"
                     /protein_id="HEU5586175.1"
                     /translation="MKEKEFRRNMAVFPIGSVMKLTDLSARQIRYYEDQELIKPDRNE
                     GNRRMYSLNDMDRLLEIKDYISEGYNIAAIKKKYAEREAKSKKAVSQTEVRRALHNEL
                     LQQGRFASVQSPFGRG"
     gene            31537..32883
                     /gene="glnA"
                     /locus_tag="VVO18_000998"
     CDS             31537..32883
                     /gene="glnA"
                     /locus_tag="VVO18_000998"
                     /EC_number="6.3.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glutamate--ammonia ligase"
                     /protein_id="HEU5586176.1"
                     /translation="MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLD
                     KVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEG
                     EPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDL
                     APTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLV
                     VKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAY
                     HFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGT
                     RLELRSVDPMANPYVAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDL
                     PSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY"
     gene            complement(32979..33098)
                     /locus_tag="VVO18_000999"
     CDS             complement(32979..33098)
                     /locus_tag="VVO18_000999"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808898.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase"
                     /protein_id="HEU5586177.1"
                     /translation="MPDIVFEIEFFHSDSLIFFYTSDDKSNSQKSQEDFSKNK"
     gene            33587..33883
                     /locus_tag="VVO18_001000"
                     /pseudo
     CDS             33587..33883
                     /locus_tag="VVO18_001000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187281.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
BASE COUNT        10367 a         5886 c         7410 g        10220 t
ORIGIN      
        1 gtttcctata tggaagtcgt cttgttttca tattgtctaa atacgagata tttactacag
       61 gttatagttg atttaaacag gtgtatagat ttctaatata tattaaggtg aaataatatc
      121 ttgtaataca ttgctatgct ctatgaaaaa agcaacgata gctaatgcac aagctcctat
      181 acttccacga tgtttgttgt aaggtaaaat ttcaatttct atattacgag taaagggaac
      241 gaagtggagc tggtcttgga ttttatccct gacttcatga gtgaaaggtt gataattaag
      301 caattgactg ttgatataga ttttatcagc aggattgatg aggagaagat ttgcaataga
      361 agtggccaat aaattgactc ctttatcaat ttgttggcgt aaagcggagt cgcctaaatt
      421 ataagccgtt aaaagggtgt ctaaatgaat gtctttttca gtctttacaa ggctttttag
      481 tacagttagt tgggaatttt taaataataa ttgggcgtgt ttgattaacc aagcatccga
      541 aatatatgtt tgtaaacaac ctttttttcc gcattcacaa tattgcccat tcaattcgac
      601 aatggtgtgt ccaatttctc cgatataagg atttttagag gctcctattt tttcttttgt
      661 gaaaaaggaa gtgtaaatac ctaatccagc gtgtaggaaa ataaagttat cgggggtatt
      721 gtgtggatta aaaaggtatt gtcctatagc catacaatcg atattatttt ttacaataaa
      781 aggaaaattg aatcttttaa ttacatttaa taaattaaaa gattcccata tggggttgtt
      841 tgtaatgata cttccggagt ctttgttata atgtccaggt attgataagc caaatccaag
      901 taattttgtt tccaaaggga cgtactctat agctgttttt atcatattgg taatggtgga
      961 attgatttct gaaataggat aatcttcatt caaaatttct gtctcgaaaa gagttttccc
     1021 ttgtaagtca catagactga gaaagatacc taggacgttt atttcaatac ctccaacaac
     1081 atacggaata ttatctgtga tagaaatagt ttttctacgt cttccagatc cggaaaactc
     1141 gctaaattca tcaccagttt cgtatatgag ggactgttcg cttagctctt ttatgatgtt
     1201 agtcgttgtt gctggagtaa gtcctgtttc attaacaata tctgtacggg atgttgctgg
     1261 atttcgatat agaaactcca gtatagtggc tctattttgt aaaaaggctg attgttttgt
     1321 aatcatttgt ttcctccttt ggtttatttt atattaaaca taagaaaaaa tcaattaaaa
     1381 ttattattct atacaaagaa aaaatgttgt aaaaacaaca aaaaatatat tgacaacgct
     1441 ttctgttagt ggtatattta atttataaaa aataaaaaaa ggagttccgg tgatgaacaa
     1501 tattttagcg tttttagaaa caaaagtcgc tccgtttggt gaaaaagttg gcaaccaacg
     1561 gcatttgaaa gctattcgtg aaggatttat gatggcaatg cctttgattt tagtcggctc
     1621 tttatttctt attctaatca gttggcctca agaggatttt acaaattggc tgaatagtgt
     1681 tggattgcta agtatcttga caactatgaa tcagtcaaca gtagcgatta tctccttggt
     1741 cgcttgtttc ggtattgcct acaggttgtc ggaaggatat ggtacagatg gtccgtcggc
     1801 agggatcata gccttatcca gttttgtatt gatggcacct cgtttttcga gtatggttta
     1861 tgataaaaat ggggagcagg tcaagcagtt atttggcggc gcaataccat tttctagcct
     1921 gaatgcatct tctttgttta tggcgattac tattggattg gttacagcag agatttatcg
     1981 tatgtttatc cagcgcggaa ttacgataaa aatgccaagt ggtgtcccag atgtggtaag
     2041 taaatcattt tcagctcttt tacctggctt tactactttt gttttgtggg ctctggtctt
     2101 aaaaggtctt gaagcggcag gagttgcagg aggtctcaac ggactcctag gtgcaattgt
     2161 tggaacaccg cttaagttaa ttgcaggaac gcttccaggt atgattctat gtgttattgt
     2221 aaactcattc ttttggttct gtggagttaa tgggggacaa gttttaaatg cttttgtaga
     2281 cccagtttgg ttacaattta ctacagaaaa ccaagaagct gtggctgcag gacaaacact
     2341 ccaacacatt attacattac cgtttaaaga tttatttgta tttattggtg gcggtggagc
     2401 gactattggt cttgcgattt gtctcttcct atttagtaag agtcgtgcga ataaaacatt
     2461 aggtaagcta gctattatac cgtctatttt taatatcaat acagctattc tatttacgtt
     2521 tccaacagtt ttaaatccga ttatgctgat tccgtttatt gctactccta caatcaatgc
     2581 cttgattacc tatgtatcaa tggctgtagg attagtaccc tatacaacag gtgtaatcct
     2641 tccgtggaca atgccaccga ttataggagg cttccttgca acaggggcta gttggcgagg
     2701 agctctatta caagttgttt tgattttggt ttctgtagca atttattatc cattcttcaa
     2761 aattgcagat aaacgcaatc ttgaaaaaga aaaagctact gttggaggga aataagatgg
     2821 ttatcagagt atttgatcaa cagaaaaata cttattctag ctttgcctta gaggaattaa
     2881 gttactatat gaatcgggtc tttaagacta acatagagct tgtcgaggag aaggaagcgg
     2941 atatttttgt aggattagtc aataaagagg acagaaaaga ccatgttctt atctcattag
     3001 acaagggtaa ggggagaatt gagtctaata caattgtagg tttacttatt ggaatttacc
     3061 gaatgtttca tgaatttggg gttgtgtata ctagaccagg gcgcggacat gactttgttc
     3121 cagagttacg atttgaagat tttttagata aacagctatc tatagatgaa acagccagtt
     3181 actatcatag gggagtatgt atagagggag cggattcatt tgaaaatata ctagatttca
     3241 ttgattggct acctaagatt gggatgaaca gttttttcat ccagtttgaa aatccttact
     3301 cttttttgaa acgttggtat gaacatgaat ttaatccata tctaaataaa gaacaatttt
     3361 caaatgaatt agtacaagaa ttgagtgata ggttggataa agaattgcaa aaaagaggtc
     3421 ttattcatca tcgtgttggt catggatgga caggtgaagt tttaggttac tcttcaaaat
     3481 ttggctggga atcaggtctt agtatttcag aggagaagaa accctatgtc gctgaaataa
     3541 acgggaaacg agaattgttt aatacggctc cgattttaac cagcctggat ttttcaaatc
     3601 cagatgtagc tgataagatg gtagaaatta tcaaggatta tgccaagaaa agacctgatg
     3661 ttaactactt acatgtatgg ttgtcggatg ctcgtaataa tatttgtgaa tgcgaaaact
     3721 gtagacaaga attggtttcg gatcagtata ttcgtattct caatcaattg gatagggctt
     3781 taacgagtga gggattagat acaaagattt gttttctgct ttatcatgag ttgttatggg
     3841 cacctcagaa agaaaaatta gataatcctg aacgctttac catgatgttt gcaccgatta
     3901 caagaacatt tgaaatgagt tatgcagatg tagattttga taattccata cctacgccta
     3961 aaccttatat gcgtaataaa attatacttc cgaattctct tgaggaaaat ttatcttatc
     4021 tttttgagtg gcaaaaagca tttaaaggag atagtttcgt atatgactat cctttagggc
     4081 gtgctcatta tggcgattta ggctatatga aaattagtca aactatttac agagatgtat
     4141 cttatctttc caacctacat ttgaacgggt acatttcgtg tcaagaatta cgtgccggat
     4201 tccctcataa ttttcctaat tatgtcatgg ggcaaatgct ctggaagaag acaagaagtt
     4261 atgaagaatt gattgaagaa tacttttctg ctttgtatgg ggaaaattgg cagtctgttg
     4321 ttgaatattt agaaaaatta tccatttatt cctcttgtga ttattttaat gcaattggca
     4381 gtcgtcaaaa tgatgtttta gcgaatcatt attatatagc ttacaatcta gctgataatt
     4441 ttttaccaat tattgaggaa aatatttcta agttattaaa tagtcaaaag gatgaatgga
     4501 aacagctcag ttatcatcgt gaatatgttg ttaagatggc gaaggcttta tatcttcaag
     4561 caactggaaa aacaaggcaa gctcaagatg aatggagaaa tgtgttgaat tatatccgtg
     4621 ggcacgaatt gctatttcaa tctaatttgg atgtttatcg tgtaattgaa gtagcaaaaa
     4681 attacgctgg tttccactta taaatcataa gtatagaaaa tgaactaagg tattcagaga
     4741 agattgaccc taaatattat gaaatttaag gatttttaag atatttaggg tcgactttct
     4801 atttgtatcg tagcgaagtc attttaataa tgatgtgtaa aagatggatc aagattgagg
     4861 aggaagaaag atgaaatcaa aagaagaaat aaatatgctt ggttttacaa ttgtcgctta
     4921 cgcaggagat gcaaggtcag atttgatgga tgctttggcg tttgcgagag atggatattt
     4981 tgaacaggca agagaattgg ttgagtctgc aaacgactca atagtgtctg cccatcgaga
     5041 acagactaat ttattagcgg aggaggcata tggagataat tttgaagtga gctttattat
     5101 gattcatggt caagatactt tgatgacaac gatgctattg tatgatcagg taaagttttt
     5161 tattgatgaa tatgaacgaa ttcgaaagat tgaagaacat attggtttgc aatgaggatt
     5221 agtcatggaa aatttacagt ttaaagtctt accgaaggag tttttattag gagctgctac
     5281 cgctgcttat caagtagagg gtgcaactag ggtagatggc aaaggaataa atatgtggga
     5341 tgtttatttg caagaaaata gtccgttctt accagatcca gctagtgatt tttattatcg
     5401 ttacgaagag gatatagctt tggcggcaga acatggtttg caggctttgc gtttatctat
     5461 ttcttgggtt cgtatatttc ctgatataga tggagatgct aatgtattag ctgttcatta
     5521 ttaccataga gtttttcagt cttgcttaaa acataatgtg attccgtttg tttctttaca
     5581 tcattttgat tcgcctcaga aaatgttaga aacaggggat tggttgaata gagagaatat
     5641 tgatcgtttc atacgatatg ctcgcttttg tttccaagaa tttacagaag tcaagcattg
     5701 gtttacaatc aatgaactga tgtctcttgc tgcaggtcaa tatataggag gtcagtttcc
     5761 tccaaatcat cattttcaat tatctgaagc aattcaagcg aatcataata tgttgttggc
     5821 gcatgctctt gcagtcctcg aatttcatca attagggatt gagggaaagg taggttgtat
     5881 tcatgcttta aagctaggct atcctattga tgggcaaaaa gaaaatattt tggcagctaa
     5941 acggtatgat gtttataata ataaatttct attagatgga acttttttgg gctactacag
     6001 tgaggacacg ctttttcact tgaatcaaat attggaagct aataattcta gctttattat
     6061 tgaagatggt gatttagaaa ttatgaagag agctgcagct cttaatacga tgtttgggat
     6121 gaattattat cgttcagaat ttattcgtga atacaaaggt gaaaatagac aagaatttaa
     6181 ttcaacagga ataaaaggac agtcttcttt taaattaaat gctctaggtg aatttgtaaa
     6241 aaaacctggt attccgacaa cagattggga ttggaatatt tatcctcaag ggttatttga
     6301 tatgttgctt cgtatcaaag aagaatatcc tcaacatccg gtcatttatt taactgaaaa
     6361 tggtacagcc cttaaagaag ttaagccaga gggcgagaat gatattattg atgacagtaa
     6421 gagaatccgt tatattgagc aacatttaca caaagtttta gaggctcgag ataggggagt
     6481 caatattcaa ggctatttta tatggtcttt gcaagatcaa ttttcttggg cgaatggcta
     6541 caataagcga tatggtcttt tctttgttga ttatgaaaca cagaagagat atattaagaa
     6601 aagtgctctt tgggtaaaag ggctaaaacg gaattaaggt tagcgatttg actgatgttt
     6661 aatatatttt aactatgagc ttaaattttt tataagagga gttttatgga taagctagtc
     6721 gctgccattg aaaagcaaca agggaaattt gaaaaaattt ctactaataa ctatatgatg
     6781 gctattaaag atggattcat tgctactatg cctttaatta tgttttcaag ctttttgatg
     6841 attattatta tgattcctaa aaatttcgga gtagagttac cgagtccagc tattgtctgg
     6901 atgagaaaag tgtatatgtt aaccatggga gttttgggtg ttattgtttc agggacagtt
     6961 gcaaagtcat tggctggaaa tgttaataga aaaatgcctc ctggaaaggt aataaatgat
     7021 atttctgtaa tgttggcagc catatgtagt tatctggtat taactgtaac gcttgtagtt
     7081 gatgagaaga cgggatctac aagtttgtcg acaaactatt taggatctca aggattggta
     7141 acttcgtttg tcagtgcctt tattactgta aatgtttacc gattctgtat taagcgagac
     7201 attactattc atttacctaa ggaagttcct ggggctatat cacaagcttt tagagatatt
     7261 tttccttttt cttttgtttt acttattagt ggtttgttag atattgtatc tcggtttagt
     7321 ttagatgttc cttttgccca agtatttcaa caactattga ctcctatttt taagggggta
     7381 gaatcatatc ctgctatgat gttgatttgg tttatgtgtg ctttgctttg gtttgttgga
     7441 attcatggac catctattgt cttacctgct gttacagctt tacaactgag caatatggaa
     7501 gagaatgctc aacttcttgc aaatgggcag ttcccttatc attctttaac acctaatttc
     7561 gggaattata tcgctgctat tggaggaacg ggggctacct ttgttgtacc atttattttg
     7621 attttcttta tgcggtctaa acaattaaaa tcggtaggta aagctacaat tactcctgtt
     7681 ttatttgcgg taaatgaacc tcttctattt ggtatgcctg ttattttgaa tccctatctt
     7741 tttgtccctt ttttgatgac tccaccagta aatgtatttc taggaaaggt ctttattgat
     7801 ttctttggaa tgaatggatt ttatatccag ttaccttggg cctttcctgg tcccttggga
     7861 ttgttaattg gaacgaattt tcaatctatc tcctttgtat ttttatcttt gatgttagtt
     7921 gtcgacatat tgatttattt gccattctgt agagcgtatg atagacagtt actgatgaaa
     7981 gaagatgttg taagctcaaa tgatattatt ttagaggagg agacaagtga aataatgcct
     8041 ggtgagatag atgtaataaa aagtaaggag ttgaaagtac tggttctttg tgcagggtct
     8101 ggaacaagtg cgcaattagc caatgcaatt aacgagggcg ctcaattagc agaagttaga
     8161 gtgattgcga attcaggagc gtacggagct cattatgata ttatgggtgt ttatgattta
     8221 attattctgg ctccacaagt tcggagttat tatagagaga tgaaggtgga tgcagaaaga
     8281 ttaggtattc agatagttgc taccagagga atggaatata ttcatttaac aaagagtcca
     8341 agtaaagcct tacaatttgt attggagcat taccaagctg tgtagtaagt ttttccatct
     8401 tttatttgag taaagatttt gcttacagat aggcttggat ttaaaaacgt tccccctttt
     8461 ttaatataag aatccctctt tcacaattgt aaaaagaggg attttgtatt ttatctctta
     8521 gaccaagttc tcttcataaa gagaaggagg attgggtaaa tctccaagcg ccctgcaatc
     8581 attgcaaagg ataggagaat ttttgagatg ggactaaaga ttgagaaact agaagtggtt
     8641 cctagaatag gcccgatatt attgaaacag ctaaagacag cgctggtcac gaccagaaaa
     8701 tcattgctat ctaggctgac aataaagata agcgctagca aaatcatagc atagatgaca
     8761 aagtacttga gaatcttatg ctgggtatct ttgtcaatca ccgttttatt aacatggagg
     8821 gtcaaaacac ggtggggcga taggattgac aaaatttggt ttttggcaat ttttgaaagg
     8881 atgaggcctc gaataatctt gagtccacct gcagttgatc cagcagagcc accgattgcc
     8941 atgaggaaaa ggaggataaa ctgggagaag aggggccagt tggtaatatc tccatatcca
     9001 aaaccagttg ttgtaatgat gttggaaacc tggaagaagg tcatttcaaa gctctttgaa
     9061 aaccctgggt agaggtagag ggtgttgagg ctaatcaagc ctgtagaaac cagtacaatg
     9121 accaagtaag cccgaagttc ttcgtcacca aagaaggcct tgatgcgacg gagcatgagg
     9181 tagtagtaga ggttgaaatt taccccaaaa accagaactc cgatactgac cagataggta
     9241 atcagtgagc tgccatagtg ggcaattccg tcgttataga cggtaaagcc tccagttccc
     9301 gctgtcccca tagcaatgac aaaactatcg tagagaggca taccagctag ataatagatg
     9361 atgacaaaga gggagaagag agctagataa aggagataga gaatctgggc agtgtttttt
     9421 agtttggata caaccttgcc aaaaacagga cctggaacct cagccttcat cacctctagg
     9481 tggctatttt tggcattgtc cataatagca agtgcaaaaa caagcactcc catccctcca
     9541 atcaagtggg taaaacttcg ccagaagagg agggaacggc tgagaaccga aacgtcgttc
     9601 aaaatacttg ctccagtagt tgtaaaccca gaactaattt caaaaaaggc atcaataagg
     9661 ctggggattt gcccagaaaa gacaaagggg agaccaccaa agaaagacca aaggatccaa
     9721 cagagggcaa cgatcaagac tccctccttg gcataaatcc gttgattttt tggcttctgt
     9781 aaactccctg aaccgcctaa caatacgaga atccctatgg tcgaaaagag ggctgtaaag
     9841 acttggctcg attcacggta atagacagcg atagccacag gaaccaagag gagaacagct
     9901 tcaatcaaaa gtaactttga aaggaggtaa cgaatcatac ttttattcat ttcttacctc
     9961 gcaatcaagt cataaatctt ggtgatgttt ggcaacaagg ttgttactag gagcttgtct
    10021 ccaacttcca acatatcctc cccagttggg aaaatagtct tgccctttcg aataatggct
    10081 gcaataagaa cccctttttt caatttcagt tgagaaagag gtttggcagt cattttattg
    10141 gcttccttga tatggaattg cagggtttcg atttggccat tggctagatg gtgcatggct
    10201 tgaaggtctg aatactgggc attaactcga ccacgaataa agtgcataat cgtatctaca
    10261 gcgatgcttt taggtgtgat gatacttgaa aaatcaggcg cattgataat ctcgaggaga
    10321 ctggtacgat tgaccttagt aatatttttc tgtacaccta ccctgtcaag gaacatagat
    10381 gtaatcagat tttcctcatc gactcctgtt agagtcgcaa cggcatcata gtgttgagca
    10441 ctttcttcca gcaggatatc ttttgcggtt ccatctcctt gaacgatgta gagatttggg
    10501 aatttctcgc taaagaagct ggcgatttca ggattgattt caatgacttt tgtatcgata
    10561 cgactatctt tgagaatacc aagtagataa taggcaattc tacctgctcc aacgatgaga
    10621 aggctcttca cggcgcgtga tttaaaataa ttatggaaga gtatcatatc gacacggtta
    10681 ccagtgacaa agattctatc tttatcctgt acagtcatgt caccgcttgg aatgataatt
    10741 tgatgatccc tctctatcgc acagacaatg acattaccaa attttttacg aaaatcagaa
    10801 atgggcattt ggcaaagacc gctggtggac ttgacgacaa attccatgag gctaacgcgt
    10861 ccaccagcaa agcgttcgac agacagggcg ttggggaagt caatgatatt cgcgatagcg
    10921 cgggcagcca agagctcagg attaacgata agagaaaaac cgagaatatt cttttccttg
    10981 aaataagagt tagaatattc agggttccgc acccgaacga tagtttcttt agctcccatt
    11041 ttcttggcta gaactgctgc aatcatgttg acttcatcgt gctcagtcag ggcgataaag
    11101 atatcacaat cttggacgct ggcttgctca agaatggcaa aatcggcccc gttaccaagg
    11161 ataccaatga tatcaaagcg actgacaata tgattgagaa cagcttcgtc ttgctcaatc
    11221 agcaaaacat catgcttttc tgcaaccaag gagcgacaga gggcaaaacc aacttttccc
    11281 cctccgacaa ggataatttt cataataaaa cctacttttt catgatgtaa ctatcatacc
    11341 ctttttcaag aaaaaatgca cctactagct aataacaaga gcttttagtg aaaattcgct
    11401 ataaggtaaa actataccct aaccaattga aatagctatt agcgactttc tctgaaatat
    11461 ggtatgataa aggatataca aggagataaa atgaataata atttactggt attacaatca
    11521 gactttggtc tggttgatgg tgcggtatcg gctatgattg gagtggcttt agaagagtct
    11581 ccaaccttaa aaatacatca cttgacgcac gatatcacgc cttataatat ttttgagggg
    11641 agctatcgtc tctttcagac ggtggattac tggcctgagg gaacgacgtt tgtatcggtt
    11701 gtcgatccag gtgtcggttc gaaacgtaag agtgtagttg ccaagactgc aaaaaatcaa
    11761 tacattgtca cgccagataa tgggacgctt tcctttatca agaaacacgt tggcattgta
    11821 gccattcgtg agatttctga ggtggccaat aggcgtcaaa acacagagca ttcttatacc
    11881 ttccacggtc gtgatgtcta tgcctatact ggtgctaaac tggccagtgg tcacattact
    11941 tttgaggaag tagggccaga gctcagtgtg gaacagattg tagagcttcc agtcgtagcg
    12001 accatcatag aagatcatct ggtgaaggga gccattgata ttctggatgt gcgtttcggt
    12061 tcgctttgga cctctatcac acgggaagaa ttttacaagc tggaaccaga atttggtgat
    12121 cgttttgaag tgaccatcta tcatgctgat atgctggtct atcaaaatca ggttgtctat
    12181 ggcaaatcat ttgcagatgt gagaattggg caacccatcc tttacatcaa ctctctctat
    12241 cgtttaggtt tggctatcaa ccaaggttcc tttgccaagg cctataatgt aggtgtcggt
    12301 tcatcttgga ccattgaaat aaagaaaata gaaggataaa ataggagaat agtatggaaa
    12361 tcaaatttac aattaaacaa gttgttgctg tcggaattgg cgctgccctc tttgtcgtca
    12421 tcgggatgat caacattcca acccctgttc caaatacaag catccagctt cagtatgcgg
    12481 tacaagcgct actttctatt atttttggac cgattatcgg tttgcttgtc gggttgattg
    12541 gtcatgcaat caaggactct cttgttggtt atggtctatg gtggacttgg attatcgcta
    12601 gcggactctt tggtttagtt gtgggacttt ttagaaagta cgttcgcgtg atcaatggtg
    12661 tttttgactg gaaagatatt cttattttta atctcattca actacttgca aatgcccttg
    12721 tttggggtgt cttggcacca cttggagatg ttgtgattta tcaagaagcg gcagaaaaag
    12781 tatttgcaca agggattgtt gcgggaattg ccaatggtgt atctgtagct attgcaggaa
    12841 ctcttctctt acttgcctat gcaggaactc aaactcgtgc aggaagtttg aaaaaggact
    12901 aatactcaat gaaaatcaaa gagcaaacta ggaagttagc cgcaggttgc tcaaaacagt
    12961 gttttgaaat tgtggataga actgacgaag tcagctcaaa acatggtttt gaggttgtag
    13021 atgaaactga cgaagtcagt aaccatacct acggcaaggc gaaactgacg tggtttgaag
    13081 agattttcga agagtataaa atgatgggga aggctgggca actagtcttt ttcgatgttt
    13141 atagattagt taggcaagta agctaagata ggaatctttt tggcgctaag attttaagag
    13201 aagagactgc aagaagggct tgatttatga taaaatagaa gtctaagaag cgaatgaaga
    13261 gagtaagatg aaagaagcta taattgagtg gaaggatttc tctttccggt atgaaacaca
    13321 acaagaaccg accttgcaag ggatagactt gaccatttac aagggagaga aagtcttaat
    13381 tgttggacca tctggatcag gtaaatctac attgggtcag tgtttgaatg ggattattcc
    13441 caatatttac aagggtcaga catatggaga atttttgata aagggtcaag cagcctttga
    13501 tatgagcatc tatgataagt ctcatctggt tagcacagtt ttgcaggata cagatgggca
    13561 gtttattggc ttgtctgtgg cagaagattt ggcgtttgct ctggaaaatg atgtgacagc
    13621 cctagatgag atgaaaggtc gtgtttataa atgggctgaa aagctggacc ttcttccttt
    13681 actggatcag cgtcctcagg atttgtcagg tggacaaaag cagcgagtca gtctggctgg
    13741 tgtcttgatt gatgaaagtc cgattctctt gtttgatgag ccactcgcca atctagatcc
    13801 caagtcaggt caggatatta tcgaattgat tgaccagatt cataaggaag aggggacgac
    13861 gactcttatt atcgagcacc gtttggagga cgttctgcat cgccctgtgg atcggattgt
    13921 cttgataaac gatggtcgta tcctttttaa tgggagccct gaccagttgc ttgcgactga
    13981 tttattgact caaaatggaa ttcgagaacc cctttatcta acgactctcc gtcaattagg
    14041 tgtggactta gtcaaggaag aacaattagc gaatctggat aacttgtcta tctcaaaagg
    14101 tcaggttcag ttgcagaatg aactggcaaa agaaacccca gcattgcagt cactctttag
    14161 actagaggaa gtatcttttt cttatgatga tagaccgatt ttaaaatccc tacatttaga
    14221 tattaaaaag ggtgaaaaga ttgctattgt cggaaaaaat ggagcaggga aatcaactct
    14281 agccaaggct ataagtagct ttattcagac ggaaggacgc tatctttggg aaaaacagga
    14341 tataaaaggc gattctgttg cagagcgggc ggaacgagta ggatatgtgc tacaaaatcc
    14401 taatcaaatg atttcaacca atatgatttt tgatgaggtg gctctagggc tccgtttgcg
    14461 aggtgtggat gagaaggaaa ttgaaacgag agtatatgaa accttgaaaa tctgtggact
    14521 ttatgaattc cgtaattggc ctatttctgc cctgtcattt ggtcagaaaa aacgtgtcac
    14581 cattgcttca attttggtct taggagctga aattattctc ctagatgaac cgactgcagg
    14641 tcaagatcag aagaactata ctgagattat ggaatttctc gaagagttac atcaaaaagg
    14701 gcataccatt gtcatgatta cccatgatat gcaattgatg ctggattatt cagaccgggt
    14761 ccttgtcatg gtggatggag aattgattgc cgatactgtt ccagccagtc tgttgagcga
    14821 tcctgagctg ttagtaaaag ccaatctaaa agaaacctcc atctttaact tggctaagaa
    14881 actagatgtg gatccactgg atttaacggc attttacaaa gaaaggagag agggatgcaa
    14941 gctaaattaa tcggttacca gcatagagat actgtgattc atcgcttgtc aggagctggg
    15001 aaacttctct ttttcattct ggtatcattg gcggccatga ttagctatga taccagaatg
    15061 ctcttgctga ttgccatctt ttcagtcttt ctcctctatt tatcagaaat tcgctttaaa
    15121 gatgtttcct ttgtagccgt ttttgcgacg gtatttgccg ttttaaacgt tttgatggtc
    15181 tatctctttt ctcccgagta tggggttgga ctttatggag agagaagtgt gatttggcag
    15241 ggaatcggtg tctacactct aaccagccag gagctctttt atctgctaaa tttggccatt
    15301 aagtatcttt gcaccattcc tctggctatt atctttttga tgacaaccca tcctagtcag
    15361 tttgcttcca gtttaaatca aattggtgtg ccctataaga ttgcttattc tgtcagcctg
    15421 accttgcgct atattccaga tttgcaggaa gaattcttta ctatcaagat gtctcaggag
    15481 gcgcgtggga tggaattatc caagaaagct tctcttatgc aacgaatcaa aggcaatctg
    15541 ctcattatta cgcccttgat ttttagctcg ctagaacgca ttgataccat tgcgactgcc
    15601 atggagcttc gccgctttgg gaaagagaaa aaacgcacat ggtatagtta tcaggccttg
    15661 aaaaaaggag actatattac cttgctcttg gcaaccttgt ttttagtagt tagtttacta
    15721 cttatcttgc agaatcaggg acgattttac aacccttgga aatagcttga aaaaattgaa
    15781 aaaatcaagt catttctatt gacaatgatt ctgaaagtgt tatactaaga aagtagtttc
    15841 gctgatttac ttcaaacctg ttgtgaggta agttaacgat gccttaacca cgctgtttgc
    15901 tgagcttgac tccgggcagt gtggctattt ttttgcaatg gtgaaaggaa gcaagtcatg
    15961 acaaatcaca ttgtattatt tgaacctcaa attccacaaa atacaggcaa tatcgcgcgt
    16021 acttgcgctg cgaccaattc tcccctccac atcatcaagc ctatgggctt tcctattgat
    16081 gaccgcaaga tgaagcgggc tggattggat tactgggata agctagagat ttatttttac
    16141 gagagcttag aagatttcat gtctcagatg aagggaaaac tctatctgat ttcgaaattc
    16201 gcggaaaaaa tctattctga ggtggattta tcgactgacg aggaccatta ttttctcttt
    16261 ggacgtgaag acaagggctt acctgaagat tttatgcgag aacatcctga gaaggctctt
    16321 cgtattccca tgaatgatga acatgtccgc agtctcaatg tgtctaatac cgtctgcatg
    16381 attgtctatg aggctcttcg ccagcagaac tttgcaggtc ttgaactcgt ccatacctat
    16441 gaagtggata aattgaaata aaaaatgaaa atgaacaaaa tgcttgcgct tgcaagcgtt
    16501 ttttgttatg ataaaagagt cttcagggca gggtgtgatt cccgaccggc ggtgacttta
    16561 actaggaaat gatcttttcc ttttatactt tgttgacaag ctttgcctaa ccagaagtta
    16621 tgcctacagc ttgtcgccta gtctaaaaga aaaatctcta tttccttctc tttaaagaag
    16681 tccgcgagcg caagctgatg tggtgagatt ccacaaccga cagtatagtc tggatgggag
    16741 aagacgaaag aatagctttg tctgttttga tagatttata gccggattgt aaccacttgc
    16801 tttgtttttc tttaatagag taagagggaa cttttgggat ataaaaagtg agaatagata
    16861 gaggaatcct ttccaacttc ttctgatttt atagaaaatt ggaggaacct gttatgacaa
    16921 acacacgtcg actttcgacc attgcaattc tatcagccat ctcatttgtg ctgatgtact
    16981 ttgactttcc gcttttacca gcggcatctt tcctcaagat cgaatttagt atcttgccag
    17041 tccttgttgg tctggtggtc atggatttgc ctgctgctct aggagtgctc ttgcttcgct
    17101 cactattgaa attgcttctt aacagccaag gagtgaatac ttacattggt ttgccgatga
    17161 atatcgtagc tttgggagtt tttgtcatcg tatttgcttt gatttggaaa aaggaacgga
    17221 caacccttcg tttcctacta ggctctctag ctggaactgt tggtttaacc ttggccatgt
    17281 tggttctcaa ctatgtttat gctgttcctt tgtacgctaa gtttgctaac tttgatattg
    17341 gaaaaatttt gggactttcc aactacctaa tgaccatggt attacctttt aacttgattg
    17401 agggtgtaat cttttccgtt tcattctggt tgttgtatgt tctcttgaaa ccaaccttaa
    17461 aacattatga gagataaaca aacattttta atgaagggca gttttgccct tttacttttc
    17521 gttattcttg gctacatggt caaattttac cctgaaacgc tggtcggttt tgaccaatcg
    17581 attcagactg ccattcgagg agacttacca gattatttga ctattctttt tcgatccctc
    17641 acacgtctga ttgatattcc agtgattatc acttgggttg tcattatagc ttttgtcttt
    17701 tatcgtaagc gatggaagat agaaagtttc ttcatgctgg gaaatctggc tttggcaggt
    17761 cttttaatcg tgacctttaa aaatatctac cagcgcccac gaccagctat tttacatctg
    17821 gtggaggaga agggattttc cttcccaagt gggcattctc tagctgtaac gctgatggta
    17881 gggactttga ttgttattct tagtcagcgg attaaagatc aggtctggag aaaaatcgta
    17941 caaatcgtcc ttggcctcta cctagtcagt gtgctggtat caagagtcta tctgggagtt
    18001 cattacccat cagacgtcct tgccagtctc tgtgtgggct tgggagtcct gtttatcgag
    18061 tttccctttt atgacaagct ccgcttccaa tggcgattta aaggcaaaca gaagtgagta
    18121 tcgaattccc ttgagagaaa gaaatgaaag tcaatatagc agatcttcat ccgactcaac
    18181 tatatttatc agaaaagaag ttgcaagata ttcagatgct ttaccagtcg gcagaaacaa
    18241 tccaagtcga tccaatcagt attcttgcct ttggagattg tttgctgatt acagatgggc
    18301 atcacagggc ttatcaggct ttattggcag gtcgggatac gatttctgct gagtgggata
    18361 gaggtggtgg tgatgaacta tatcatctct atgcgcaagc ttgcgaggaa agaaagattt
    18421 actctgtttt tgatttagaa gatcgtatcc tagctcaaga tgggtatgaa gcaaaatggt
    18481 ataactggtg tgatggtttt aatcaagcag caactctttt gttgaaaagg tagtgcattg
    18541 tgttttgttc cttattataa ggtcaattat tgtgaggaag cttttgcttg gtatcaggat
    18601 gtgaacttgg tttacctcgt agatggggtg aagcttcctt acagtcaagc gaccttggaa
    18661 gccatgtatt cctatttgga tcggcatggt gagctttttt ggattgaagt caaggagaag
    18721 ggagaatggt ttccaattgg ggatattaca ctatctcagg ataatctccc cattgtgatt
    18781 gggaattccg cttaccaaca tcgaggactt ggaaaaaaga ttctaagtgc tttgattgaa
    18841 ttggctcgag taaaaggatg gaaagaattg agagtcaagg aaatctacac ctacaatcat
    18901 gcttctagga ggtgtttcaa gtcgcttgga tttgtggaaa atggagcaac agaaaaagga
    18961 aggagtttta tattggaatt agtctaatcc tgccactttc tcccccttaa cctttgacta
    19021 ttccgcaaaa ttatcgtaaa ataaagagta aatgataaaa tgaggtcaga gtctgttcgc
    19081 tctggcgata gtagtataaa tgaggagaaa cgctttggaa ttagaagtat ttgctgggca
    19141 agaaaaaagt gaactatcta tgattgaggt agcgcgtgct atcttggaac ttcgtggtcg
    19201 cgatcatgag atgcatttta gcgatcttgt aaacgaaatt caaaactacc ttggaacatc
    19261 aaacagcgat atccgcgaag ctttgccttt gttctacaca gagttgaact ttgacggtag
    19321 cttcatctca cttggggaca acaaatgggg tcttcgttca tggtatggtg tggacgaaat
    19381 cgacgaagaa atcatcgctc ttgaagaaaa tgacgacgat gaagtagcac caaaagctaa
    19441 gaaaaaacgt gtcaatgcct ttatggatgg tgattcagat gccattgact acaatgcaga
    19501 tgatccagaa gacgaagatg catacgaagc agatccagct ctttcatacg atgatgaaaa
    19561 tccagatgat gaaaaaaatg aagtggaagc ttatgatgca gaaatcaacg aaatcgctcc
    19621 agatgacttg ggagaagatg tggatctcaa cgaagacgac gacgagtttt cagatgacga
    19681 tgctgaaacc agcgaggaat aagagttagc tattgacaat tatcctattt ttaggtatca
    19741 tattgtttgg gcacctcttt tagaggtcgg ggctccctag ttcttaggga gctatttttg
    19801 ttttttcaag aagttatctt cttgtatttt atactcaatg aaaatcaaag agcaagctag
    19861 gaaactagcc gtaggctgct caaaacacta ttttgaggtt gtagataaga ctgacaaagt
    19921 caggaacaca tatctacggc aaggcgacgt tgacgcggtt tgaagagatt ttcgaagagt
    19981 attagctgtg aatctggtgc agtcgtccca gattattctt attagtaggg tcttgttttc
    20041 tatatcccct cgtagttaac aagaccttga gcattttaga aagaggaatc tatgtctacg
    20101 aaatatattt ttgtaactgg tggtgtggta tcgtctattg ggaaagggat tgtggcagcg
    20161 agtctaggcc gtctcttgaa aaatcgtggt ctcaaagtaa ccattcaaaa gtttgaccct
    20221 tatatcaata ttgatccggg aaccatgagt ccttaccagc acggggaagt ttttgtgaca
    20281 gatgacggag ctgagacaga tttggacttg ggtcactatg aacgtttcat cgatatcaat
    20341 ctcaacaaat attccaacgt gacaactggg aaaatttaca gtgaagttct tcgtaaagaa
    20401 cgccgtggag aataccttgg ggcaactgtt caagtcattc ctcatatcac agatgctttg
    20461 aaagaaaaaa tcaagcgtgc cgctctaacg accgactctg atgtcattat cacagaggtt
    20521 ggtggaacag taggagatat cgagtccttg ccattcctag aggctcttcg tcagatgaag
    20581 gcagatgtgg gtgcggataa tgtcatgtat atccatacaa ccttgcttcc ttacctcaag
    20641 gctgctggtg aaatgaaaac caaaccaacc caacactctg tcaaagaatt gcgtggcttg
    20701 ggaatccaac caaatatgtt ggttattcgt acagaagagc cagctggtca aggaattaaa
    20761 aataaactgg cccagttctg tgatgtggca ccagaagccg ttatcgaatc gttggatgtt
    20821 gaacaccttt accaaattcc actgaacttg caggcacaag ggatggacca aattgtttgt
    20881 gatcatttga aattagacgc accagcagcg gatatgacag aatggtcagc catggtggac
    20941 aaggtcatga acctcaagaa acaagttaag atttcccttg ttggtaagta tgtggagttg
    21001 caagatgcct atatctcagt ggtcgaagcc ttgaaacact ctggctatgt caatgatgta
    21061 gaagttaaaa tcaattgggt caatgccaat gatgtgacag cagagaatgt agcagaactc
    21121 ttgtctgatg cggacgggat catcgtacca ggtggttttg gtcaacgtgg tacagaaggg
    21181 aaaatccaag ccatccgcta tgcgcgtgaa aatgatgttc caatgttggg agtctgcttg
    21241 ggaatgcagt tgacatgtat cgagtttgct cgtcacgttt taggtcttga aggtgccaat
    21301 tctgcagagc ttgcaccaga aacaaaatac cctatcattg atatcatgcg tgatcagatt
    21361 gatattgagg atatgggtgg aacccttcgt ttgggacttt atccgtctaa gttgaaacgt
    21421 ggctctaagg ctgctgctgc ttatcacaat caagaagtgg tgcaacgccg tcaccgtcac
    21481 cgttatgagt ttaataatgc cttccgtgag cagtttgagg cagcaggttt tgtcttttca
    21541 ggagtttctc cagacaatcg tttggtagaa atcgtggaaa ttcctgaaaa taaattcttt
    21601 gtagcttgtc agtatcaccc tgaactgtca agccgtccaa accgaccaga agaactctac
    21661 actgcctttg ttactgcagc ggttgagaac agcaattagc aaaatcagaa cctttgagaa
    21721 aaatctcaga ggttttttgc atacaatgat attgcagtat atctgaggta ggagtcctct
    21781 gtatgtacct gctaccgttg aaattaatag cgactccctc ttgccctgtg ctagtgaatg
    21841 gatttatcag tatattgaaa tgaaataaaa tctgaacaaa ttaattcgga aagccaaatc
    21901 aatttctagc aaagttttag gaactggatt gtatagtgaa ttgaaataag atgtgaacat
    21961 ctctatcagg aaagtcaaat taatttatag aaatatttta gcagtcaaga tggactgtta
    22021 tagattcaat acattatact tttttaattt aatccactat agtaaaatga aataataaca
    22081 ggacaaatcg atcaggacag tcaaatcgat ttctaagaat gttttagaaa tagaggtgta
    22141 ctattctagt ttcaatatac tatatatctg cagaatactc tttcagtttc attcagccta
    22201 gtcttgctta ggaaaaagta agaagccatc caattatgat ggatagcttc ttggttctta
    22261 gatttgttct gcaaaaacct tttcagcaag gttcatagcg tggtctgata cacgagtgta
    22321 gtgtgagatg atgtcgataa agttgacccc agcttgtgtt gaacattcgc ctttgttgag
    22381 gcgtttgatg tgggtttttc tgagaacacg ttctatctta ttgattgctt catgacgttc
    22441 tacaagactg cgtgcttttt caatatcatt gttttccaca ctatccagag catctttgat
    22501 aaagtcacta gtttggcggt aaacttcctc taattctttc aaggcggcat cagaaaattc
    22561 aacatttttc cgttgaagat agtcagtcag attgagtaga gcctccgtgt ggtctccaat
    22621 ccgttccaaa tcacgggagg aatcaaggat attggtaagc acttcacttt ctttttggct
    22681 gagagcttcg cttgaaaggg caatgagata acgtgttaat tgctcatcga tggtgttaat
    22741 tgcttcttcg gttttatgcc ctttttcagc aactttttca tccaagccaa tgatgtactt
    22801 ataggaaagg tcaaaggctt tagcagcgta gtttcctaag tgcaagagct ctttcttagc
    22861 atttcctaga gcgatagatg gggcctgttt gatgaaatgt tcatcaagat ataagggttc
    22921 gtatttgaca acctcgtcct ctccaggaat aatcttggtt acaaagtaag ccagagctcc
    22981 gataaatgga aattggacaa tggtgttggt aatattaaag gttccgtgag caaaggcgat
    23041 ggtcatttcc ggtgctagat ttagcgtagc ttcaaaccaa tgaatcagga cagtaaaagg
    23101 aactagaaaa ataacgcaga cgactgttcc gataacgttg aaggcaacat gagctcctgc
    23161 tacccgttta gctgcaatat tagcccctaa agaggcaatg atggctgtaa tggttgtccc
    23221 gatattgtca ccaaatagaa ctggcaaagc tccctgtagg tcaattagat tgccggcgta
    23281 gaggttttgt aaaatcccaa tggtagccga agaagcttga attagcaagg tcaagccagt
    23341 accgacaaag acacccaaaa caggattctt acttagctca atcatatagt ccttaaagac
    23401 ctgtaaatcc ttgagtggag ccattgcgcc gctcatgaga ttgagggcaa aaaagatacc
    23461 accgatacca aagaggatgc gtccgatatt attgactgtc cgattttttg taaaaaagag
    23521 acagacggca ccgataaaga gcataggtag ggcatagtta cctaatttaa aaccgatgag
    23581 aaaggatgtg acagttgtcc caatattagc acccatgaca atcccgatag cctgacgtaa
    23641 ggttaagaga ccggcactga ccaggccgac tgtaataact gttacaccag aactagactg
    23701 aattagagca gtcatcccaa taccaaccag aactccaaag aaaggattac tagtatattt
    23761 gtcaatgtaa aaacgaaggc gatctccagc agcttgttgt aaaccgtctc ccatggtctt
    23821 gatgctatat aagaatagcc ccagaccacc taaaaagtga aataaaattt cctgccaatt
    23881 aatggacatt tctttttcct ccgaaaaata atcgcggaat atctcctatt ctattttaaa
    23941 ggataaaagt aaatctaaca agtgttaatg tcaagtttgt aaaagaaaat tataattgat
    24001 aagtgtatta tttttaagag tttttaacct tattttagat ttgtgaaaac agctattgtt
    24061 ttttgtctaa aaatgtttta ggataaaaat gtgattatca tgattctaga gttaaaaaac
    24121 tacagaatat aaagcgcttt cttgaaaaca acaaaatcaa tcttttagga ggagaaaatg
    24181 aagaatccat tttttgaaag acgttgtcgt tacagtattc gtaagttatc agtaggagcc
    24241 tgctcgctga tgattggtgc tgttttattt gctggtccag ccttggctga agaaactgca
    24301 gttcctgaaa atagcggagc taatacagag cttgtttcag gagagagtga gcattcgacc
    24361 aatgaagctg ataagcagaa tgaaggggaa catactagag aaaacaagct agaaaaggca
    24421 gaaggagtag cgacagcatc tgaaactgca gaagcagcta gcgcagctaa accagaggaa
    24481 aaagcaagtg aggtggttgc agaaacacca tctgcagaag caaaacctaa gtctgacaag
    24541 gaaacagaag caaagcccga agcaactaac caaggggatg agtctaagcc agcagccgaa
    24601 gctaataaga ctgaaaaaga agtccagcca gatgtcccta aaaatacaga aaaaacatta
    24661 aaaccaaagg aaatcaaatt taattcttgg gaagaattgt taaaatggga accaggtgct
    24721 cgtgaagatg atgctattaa ccgcggatct gttgtcctcg cttcacgtcg gacaggtcat
    24781 ttagtcaatg aaaaagctag caaggaagca aaagttcaag ccttatcaaa caccaattct
    24841 aaagcaaaag accatgcttc tgttggtgga gaagagttca aggcctatgc ttttgactat
    24901 tggcaatatc tagattcaat ggtcttctgg gaaggtctcg taccaactcc tgacgttatt
    24961 gatgcaggtc accgtaacgg ggttcctgta tacggtacac tcttcttcaa ctggtctaat
    25021 agtattgcag atcaagaaag atttgctgaa gctttgaagc aagacgcaga tggtagcttc
    25081 ccaattgccc gtaaattggt agacatggcc aagtattatg gctatgatgg ctatttcatc
    25141 aaccaagaaa caactggaga tttggttaaa cctcttggag aaaagatgcg ccagtttatg
    25201 ctctatagca aggaatatgc tgctaaggta aaccatccaa tcaagtattc ttggtacgat
    25261 gccatgacct ataactatgg acgttaccat caagatggtt tgggagaata caactaccaa
    25321 ttcatgcaac cagaaggaga taaggttccg gcagataact tctttgctaa ctttaactgg
    25381 gataaggcta aaaatgatta cactattgca actgccaact ggattggtcg taatccttat
    25441 gatgtatttg caggtttgga attgcaacag ggtggttcct acaagacaaa ggttaagtgg
    25501 aatgacattt tagacgaaaa tgggaaattg cgcctttctc ttggtttatt tgccccagat
    25561 accattacaa gtttaggaaa aactggtgaa gattatcata aaaatgaaga tatcttcttt
    25621 acaggttatc aaggagaccc cactggccaa aaaccaggtg acaaagattg gtatggtatt
    25681 gctaacctag ttgcggaccg tacgccagcg gtaggtaata cttttactac ttcttttaat
    25741 acaggtcatg gtaaaaaatg gttcgtagat ggtaaggttt ctaaggattc tgagtggaat
    25801 tatcgttcag tatcaggtgt tcttccaaca tggcgctggt ggcagacttc aacaggggaa
    25861 aaacttcgtg cagaatatga ttttacagat gcctataatg gcggaaattc ccttaaattc
    25921 tctggtgatg tagccggtaa gacagatcag gatgtgagac tttattctac taagttagaa
    25981 gtaactgaga agaccaaact tcgtgttgcc cacaagggag gaaaaggttc taaagtttat
    26041 atggcattct ctacaactcc agactacaaa ttcgatgatg cagatgcatg gaaagagcta
    26101 accctttctg acaactggac aaatgaagaa tttgatctta gctcactagc gggtaaaacc
    26161 atctatgcag tcaaactatt tttcgagcat gaaggtgctg taaaagatta tcagtttaac
    26221 ctaggacaat taactatctc ggacaatcac caagagccac aatcgccgac aagcttttct
    26281 gtagtgaaac aatctcttaa aaatgcccaa gaagcggaag cagttgtgca atttaaaggc
    26341 aacaaggatg cagatttcta tgaagtttat gaaaaagatg gagacagctg gaaattacta
    26401 actggctcat cttctacaac tatttatcta ccaaaagtta gccgctcagc aagtgctcag
    26461 ggtacaactc aagaactgaa ggttgtagca gtcggtaaaa atggagttcg ttcagaagct
    26521 gcaaccacaa cctttgattg gggtatgact gtaaaagata ccagcctacc aaaaccacta
    26581 gctgaaaata tcgttccagg tgcaacagtt attgatagta ctttccctaa gactgaaggt
    26641 ggagaaggta ttgaaggtat gttgaacggt accattacta gcttgtcaga taaatggtct
    26701 tcagctcagt tgagtggtag tgtggatatt cgtttgacca agccacgtac cgttgttaga
    26761 tgggtcatgg atcatgcagg agctggtggt gagtctgtta acgatggctt gatgaacact
    26821 aaagactttg acctttatta taaagatgca gatggtgagt ggaagctagc taaggaagtc
    26881 cgtggtaaca aagcacacgt gacagatatc actcttgata aaccaatcac tgctcaagac
    26941 tggcgcttga atgttgtcac ttctgacaat ggaactccat ggaaggctat tcgtatctat
    27001 aactggaaaa tgtatgaaaa gcttgatact gagagtgtca atattccgat ggccaaggct
    27061 gcagcccgtt ctctaggcaa taacaaggta caagttggct ttgcagatgt accggctgga
    27121 gcaactatta ccgtttatga taatccaaat tctcaaactc cgctcgcaac cttgaagagc
    27181 gaagttggag gagacctagc aagtgcacca ttggatttga caaatcaatc tggtcttctt
    27241 tattatcgta cccagttgcc aggcaaggaa attagtaatg tcctagcagt ttccgttcca
    27301 aaagatgaca gaagaatcaa gtcagtcagc ctagaaacag gacctaagaa aacaagctac
    27361 gccgaagggg aggatttgga ccttagaggt ggtgttcttc gagttcagta tgaaggagga
    27421 actgaggacg aactcattcg cctaactcac gcaggtgtat cagtatcagg ttttgatacg
    27481 catcataagg gagaacagaa tcttactctc caatatttgg gacaaccagt aaatgctaat
    27541 ttgtcagtga ctgtcactgg ccaagatgaa gcaagtccga aaactatttt gggaattgaa
    27601 gtaagtcagg aaccgaaaaa agattaccta gttggtgata gcttagactt gtctgaagga
    27661 cgctttgcag tggcttatag caatgacacc atggaagaac attcctttac tgatgaggga
    27721 gttgaaattt ctggttacga tgctcaaaag actggtcgtc aaaccttgac gcttcgttac
    27781 caaggtcatg aagtcaactt tgatgttttg gtatctccaa aagcagcatt gaacgatgag
    27841 tacctcaaac aaaaattagc agaagttgaa gctgctaaga acaaggtggt ctataacttt
    27901 gcttcaccag aagtaaaaga agctttcttg aaagcaattg aagcggccga acaagtgttg
    27961 aaagaccatg aaactagcac ccaagatcaa gtcaatgacc gacttaataa attgacagaa
    28021 gctcataaag ctctgaatgg tcaagagaaa tttaaggaag aaaagacaga gcttgatcgt
    28081 ttaacaggtg aggttcaaga actcttggct gccaaaccaa accatccttc aggttctgcc
    28141 ctagctccgc ttcttgagaa aaacaaggcc ttggttgaaa aagtagattt gagtccagaa
    28201 gagcttgcaa cagcgaaaca gagtctaaaa gatctggttg ctttattgaa agaagacaag
    28261 ccagcagtct tttctgatag taaaacaggt gttgaagtac acttctcaaa taaagagaag
    28321 actgtcatca agggtttgaa agtagagcgt gttcaagcaa gtgctgaaga gaagaaatac
    28381 tttgctggag aagatgctca tgtctttgaa atagaaggtt tggatgaaaa aggtcaagat
    28441 gttgatctct cttacgcttc tattgtgaaa atcccaattg aaaaagataa gaaagttaag
    28501 aaagtatttt tcttacctga aggcaaagag gcagtagaat tggcttttga acaaacggat
    28561 agtcatgtta tctttacagc accacacttt actcattatg cctttgttta tgaatctgct
    28621 gaaaaaccac aacctgctaa accagcacca caaaacaaag tccttccaaa acctacttat
    28681 caaccggctt ctgatcaaca aaaggctcct aaattggaag ttcaagagga aaaggttgcc
    28741 tttcatcgtc aagagcatga aaatactgag atgctagttg gggaacaacg agtcatcata
    28801 cagggacgag atggactgtt aagacatgtc tttgaagttg atgaaaacgg tcagcgtcgt
    28861 cttcgttcaa cagaagtcat ccaagaagcg attccagaaa ttgttgaaat tggaacaaaa
    28921 gtaaaaacag taccagcagt agtagctaca caggaaaaac cagctcaaaa tacagcagtt
    28981 aaatcagaag aagcaagcaa acaattgcca aatacaggaa cagctgatgc taatgaagcc
    29041 ctaatagcag gcttagccag ccttggtctt gctagtttag ccttgacctt gagacggaaa
    29101 agagaagata aagattaaat atcgaaaaat cttgtgaaat ctttccttat atttccaaag
    29161 tgtgatataa tagtttcgaa taaaataaat aaaggagttt ttgtaacatg gcaaaactta
    29221 ctgttaaaga cgttgacttg aaaggtaaaa aagtcctcgt tcgtgttgac ttcaacgtac
    29281 cattgaaaga tggcgtaatc actaacgata accgtatcac agcagctctt ccaactatta
    29341 agtacatcat cgaacaaggt ggacgtgcaa ttcttttctc tcaccttgga cgtgtgaaag
    29401 aagaagctga taaagctggt aaatcacttg ctcctgtagc agctgacttg gcagcaaaac
    29461 ttggtcaaga tgttgttttc ccaggtgtca ctcgtggtgc tgaattggaa gcggcaatca
    29521 acgctcttga agatggacaa gttctcttgg ttgaaaacac tcgttacgaa gatgttgacg
    29581 gcaagaaaga atctaaaaac gatcctgaac ttggtaaata ctgggcatca cttggagatg
    29641 gtatcttcgt aaacgatgca ttcggtacag ctcaccgtgc acacgcatct aacgttggta
    29701 tctcagcaaa cgttgaaaaa gcagttgctg gtttccttct tgaaaacgaa attgcctaca
    29761 tccaagaagc agttgaaact ccagaacgtc cattcgtggc tatccttggt ggttcaaaag
    29821 tttcagacaa gatcggtgtt atcgaaaact tgcttgaaaa agctgataaa gtccttatcg
    29881 gtggtgggat gacttacaca ttctacaaag cacaaggtat cgaaatcggt aactcacttg
    29941 tagaagaaga caaattggat gttgcgaaag ctcttcttga aaaagcaaat ggtaaattga
    30001 tcttgccagt tgactcaaaa gaagctaacg catttgctgg ttacactgaa gtgcgtgaca
    30061 ctgaaggtga agcagtttct gaaggcttcc ttggtcttga catcggtcca aaatctatcg
    30121 ccaaatttga cgaagctttg actggtgcca aaacagttgt atggaacgga cctatgggtg
    30181 tatttgaaaa cccagatttc caagctggta caatcggtgt gatggacgct atcgtgaaac
    30241 aaccaggagt taaatcaatc atcggtggtg gtgactcagc tgccgcagcg attaaccttg
    30301 gccgtgcaga caagttctca tggattagta cgggtggtgg agcatcaatg gaacttcttg
    30361 aaggtaaggt tcttccagga cttgcagcct tgacagaaaa ataagatttt ataaacaaat
    30421 caaagaagag agggatgaaa gttcctcttt tcttttgctt aaaataaaaa cgcttcctct
    30481 caactattac tcataaaaat caccgattta tgataaaatg gaaatagaaa gttgagatta
    30541 tgagttattt taaaaaatat aaattcgata aatcccagtt caaacttggt atgcgaacct
    30601 ttaaaacagg tattgctgtt tttctagttc tcttgatttt tggctttttt ggctggaaag
    30661 gtcttcaaat tggtgctttg acagccgttt ttagcctgag ggagagtttt gatgagagtg
    30721 ttcattttgg gacttcgcgt attctaggaa atagtatcgg tggactctat gccttggtct
    30781 tcttcttatt aaatactttt ttccacgaag ccttttgggt gaccttggta gttgttccaa
    30841 tctgcaccat gttaaccatt atgacaaatg tagccatgaa taacaaagca ggggttattg
    30901 gtggtgtagc agctatgtta atcattaccc tatcaattcc aagtggtgag acaattttgt
    30961 acgtgtttgt gcgtgtatta gaaacgttta tgggagtttt tgtcgcaatt atcgtaaatt
    31021 acgatattga tcgtattcgt ctctttttag agaaaaaaga aaaataatgt tacattttat
    31081 aacattatca attgacgttt gtcttttttt agactataat agacagaaag aaggaaattg
    31141 taaatgaagg aaaaagaatt tcgccgaaat atggctgttt ttcctatcgg cagtgttatg
    31201 aagttgaccg atttatcggc gcgtcagatt cgttattatg aagatcaaga gttgatcaag
    31261 cccgatcgaa acgaaggaaa tcgtcgcatg tattccttga atgacatgga tcgtctgctt
    31321 gaaatcaaag attatatctc tgaaggttat aatatcgctg ccattaagaa aaaatatgct
    31381 gaacgtgaag cgaaatccaa gaaagcggtt agtcagactg aagtacgtcg tgcacttcac
    31441 aatgaactcc tccaacaggg gcgttttgct tcagtacagt caccttttgg tcgcggttag
    31501 gcaaccgcaa gtagtcatag attaaggaga aaacttatgc caatcacagc tgcagatatt
    31561 cgtcgtgaag tcaaggaaaa aaatgttacc tttattcgtc ttatgttctc agatattttg
    31621 ggaaccatga aaaacgtcga aattcctgct acagatgaac agttagataa ggtcttgtcg
    31681 aacaaggtta tgtttgatgg atcttctatt gaaggttttg tacgtatcaa tgagtcggat
    31741 atgtacttgt acccggactt ggatacatgg acagtcttcc cttggggaga tgaaaatgga
    31801 agtgttgcag gtctgatctg tgatgtttat acaacagaag gtgaaccatt tgcgggtgac
    31861 cctcgtggta atttgaaacg agctcttcgt cacatggaag aagttggatt caaatccttc
    31921 aaccttggtc cagagccaga attcttccta tttaagttgg atgaaaatgg ggacccaaca
    31981 cttgaagtga atgacaaggg tggctacttt gatttggcac ctactgacct tgcggacaac
    32041 acacgtcgtg agattgtgaa tgtcttgacc aaaatgggat ttgaagtaga agcgagtcac
    32101 cacgaggttg cggttggaca gcatgagatt gactttaagt acgatgaagt tctccgtgct
    32161 tgtgataaga ttcaaatctt taaacttgtt gttaaaacca ttgctcgcaa acacggactt
    32221 tacgcaacat ttatggcgaa gccaaaattt ggtattgctg gctcaggtat gcactgtaat
    32281 atgtccttgt ttgatgcaga aggaaataac gccttctttg atccaaatga tccaaaagga
    32341 atgcagttgt cagaaacagc ttaccatttc ctaggcggtt tgatcaagca tgcttacaac
    32401 tatactgcca tcatgaaccc aacagttaac tcatacaaac gtttggttcc aggttatgaa
    32461 gcgcctgttt acattgcttg ggctggtcgt aaccgttcgc cacttgtgcg cgtacctgct
    32521 tcacgtggta tgggaactcg tcttgagttg cgttcagtgg atccaatggc gaacccttac
    32581 gttgctatgg ctgttctttt ggaagttggt ttgtatggta ttgaaaataa aatcgaagca
    32641 ccagctccta tcgaagaaaa tatctacatc atgacagcag aagagcgcaa ggaagctggt
    32701 attacagacc ttccatcaac tcttcacaac gctttgaaag ctttgacaga agatgaagtg
    32761 gttaaagctg ctctcggaga tcacatctac actagcttcc ttgaagccaa acgaatcgaa
    32821 tgggcaagtt atgcaacctt cgtttcacaa tgggaaattg ataattattt agacctttac
    32881 taatactaat atagaagaaa gattgcctgt gggtaaacag tcacacagca gtctaagcca
    32941 tcaaatacct ataaccctta aaatagcgat ttcggtcgct atttattttt cgaaaaatcc
    33001 tcttgactct tttgcgaatt agatttatca tcagacgtgt agaagaaaat caaggagtca
    33061 ctatggaaaa attcaatttc aaaaacaata tcgggcaaga aaacaagtta cttcaaatcg
    33121 aaatctacaa gtttactaac ttttacaagc ttcaaaatta cacatctgta aatatttttt
    33181 cgaaagatat atttgaagcc atagtaaatt gagactagaa tagtacacta catctgctaa
    33241 aaatttctag aaactaattt aactttccta atcgatttgt ttacatctta tttcaatcta
    33301 ctatattatc tcaataaatg atgatggcga ctgttttgtt tgtgcttgtc gatttttgaa
    33361 tccctgatcg agcggaagaa tatttctgcc gaggttgcca aggggaaaat actgaagata
    33421 ttgaatttta tgatgaacaa ttacaggcag aaaaggtgga ggttttgaat attcgattgg
    33481 aagtaaaaaa ttgaattatc tacaatctca tcaacaataa acctatttca accccattat
    33541 ctataggcgt atttttacgc ctttttatat acttgaagca cataagaaac attatgggaa
    33601 gtttgctgat ggaagcactc aagaaattga tgttccttat gatattcctg atacttggga
    33661 gtgggtgagg ataaaatcaa tttattggaa ttttgggcaa aataagccag agaaatcctt
    33721 taggtatata gatacgtcta gtattgatag aaaaaagaac ataatcaact acaaaaatct
    33781 acaatatctt tcacctgaac aagcgccttc ccgtgctaga aaattagttt cgcagaatag
    33841 tgtcttattt tcaacagtta gaccatatct aaaaaatatt gct
//
LOCUS       DAVHIZ010000021        32767 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.021, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000021 DAVHIZ010000000
VERSION     DAVHIZ010000021.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32767)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32767)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32767
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.021"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(41..376)
                     /locus_tag="VVO18_001001"
     CDS             complement(41..376)
                     /locus_tag="VVO18_001001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586178.1"
                     /translation="MEHLFKFLLLAPYFYFDNWIEKANRNSKFFPIFYYFYWFYIPFY
                     SLFSLAWTVVSVLFFNTVLRNVTDIKLWGIWFLFILLAIGMNWLTYSCFKEMFRLRQE
                     LGKSKGGRH"
     gene            complement(467..1777)
                     /gene="der"
                     /locus_tag="VVO18_001002"
     CDS             complement(467..1777)
                     /gene="der"
                     /locus_tag="VVO18_001002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018377046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase Der"
                     /protein_id="HEU5586179.1"
                     /translation="MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYA
                     TGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEY
                     VARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIV
                     ENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFT
                     DTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDK
                     RIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQ
                     RLHKLPEMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKP
                     PTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK"
     gene            complement(1791..2504)
                     /locus_tag="VVO18_001003"
     CDS             complement(1791..2504)
                     /locus_tag="VVO18_001003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140867.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent oxidoreductase"
                     /protein_id="HEU5586180.1"
                     /translation="MTETIKLMKAHTSVRRFKEQEIPQVDLNEILTAAQMASSWKNFQ
                     SYSVIVVRSQEKKDALYELVPQEAIRQSAVFLLFVGDLNRAEKGARLHTDTFQPQGVE
                     GLLISSVGAALAGQNALLAAESLGYGGVIIGLVRYKSEEVAELFNLPDYTYSVFGMAL
                     GVPNQHHDMKPRLPLENVVFEEEYQEQSTEAIQAYDRVQADYAGARATTSWSQRLAEQ
                     FGQAEPSSTRKNLEQKKLL"
     gene            complement(2501..3397)
                     /gene="dnaI"
                     /locus_tag="VVO18_001004"
     CDS             complement(2501..3397)
                     /gene="dnaI"
                     /locus_tag="VVO18_001004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398880.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein DnaI"
                     /protein_id="HEU5586181.1"
                     /translation="MESVGDVLKRQPSRFYYQDLVQKIMKDPDVAAFIQQESLTPEEL
                     NRSISKFNQYITERDKFLRGDTDYIAKGYKPILVKNHGYADVSYEETPELIAAEKEAA
                     IKNRLKLINLPASLKKASLAQVDLDDLGRLPVFEKLLAFVEQYPAIRKGLYLYGDFGV
                     GKSFMVAALAHDLSEKRGVSSTLLHYPSFVIDVKNAISDGNVKTLVDEIKLSEVLILD
                     DIGAEQSTVWVRDEILQVILQYRMQENLPTFFTSNFNFEDLEKHFAKVKHGNDETWEA
                     RRVMERIRYLAEETRLEGVNRR"
     gene            complement(3398..4567)
                     /locus_tag="VVO18_001005"
     CDS             complement(3398..4567)
                     /locus_tag="VVO18_001005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation and membrane attachment
                     family protein"
                     /protein_id="HEU5586182.1"
                     /translation="MKPIDRFSYLKNNRVSQDTSSLVQCYLPIIGQEALSLYLYTISF
                     WDNGRKEYLFSSILNHLNFGMDRLIKSLKILSAFNLLTLYQKGDVYQLALHAPLSSQD
                     FLGHPVYRRLLEKKIGDSAVEDLKVESADGEEIPVSLNQVFPELAELGSQEDLGLKKK
                     VANDFDLDHFRQLMARDGLRFADEQSDVLNLFAIAEEKKWTWFETYQLAKSTAVSQVI
                     STKRMREKIAQKPVSSDFSPKETTIIKEAKSKTALQFLAEIKQTRKGTITQTERELLQ
                     QMAGLGLLDEVINIILLLTFNKVDSANINEKYAMKVANDYAYQKIHSAEKAVLRIRER
                     GQKAKTQKQNQTAPVKTNVPKWSNPEYKNETSEETRLELERKKQELLARLEKGGD"
     gene            complement(4568..5041)
                     /gene="nrdR"
                     /locus_tag="VVO18_001006"
     CDS             complement(4568..5041)
                     /gene="nrdR"
                     /locus_tag="VVO18_001006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001203675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor NrdR"
                     /protein_id="HEU5586183.1"
                     /translation="MRCPKCGATKSSVIDSRQAEEGNTIRRRRECDECQHRFTTYERV
                     EERTLVVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSDEINMVVNRIEQKLRGRNENE
                     IQSEDIGSLVMEELAELDEITYVRFASVYRSFKDVSELESLLQQITQSSKKKKER"
     gene            5181..5546
                     /locus_tag="VVO18_001007"
     CDS             5181..5546
                     /locus_tag="VVO18_001007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU5586184.1"
                     /translation="MSWTFDNKKPIYLQIMEKIKLQIVSHTLEPNQQLPTVRELASEA
                     GVNPNTIQRALSDLEREGFVYSKRTTGRFVTKDKELIAQSRKQLSEEELEHFVSSMTH
                     FGYEKEELPGVVSDYIKGV"
     gene            5551..6246
                     /locus_tag="VVO18_001008"
     CDS             5551..6246
                     /locus_tag="VVO18_001008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586185.1"
                     /translation="MSLLAFENVSKSYGATPALENVSLDIPAGKIVGLLGPNGSGKTT
                     LIKLINGLLQPDQGRVLINDMDPSPATKAVVAYLPDTTYLNEQMKVKEALTYFKTFYK
                     DFNLERAHHLLADLGIDENSRLKKLSKGNKEKVQLILVMSRDARLYVLDEPIGGVDPA
                     ARAYILNTIINNYSPTSTVLISTHLISDIEPILDEIVFLKDGKVVRQGNVDDIRYESG
                     ESIDQLFRQEFKA"
     gene            6263..7030
                     /locus_tag="VVO18_001009"
     CDS             6263..7030
                     /locus_tag="VVO18_001009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586186.1"
                     /translation="MFWKLVHYEFKNVNKWYLALYAAVLVLSALIGIQTQGFKNLPYQ
                     ESQATMLLFLATVFGGLMLTLAISTIFLIIKRFKGSVYDRQGYLTLTLPVSEHHIITA
                     KLIGAFIWSLISTAVLALSAVIILALTAPEWIPLSYVITFVETHLPQIFLTGISFLLN
                     TISGILCIYLAISIGQLFNEYRTALAVAAYIGIQIVIGFIELFFNLSSNFYVNSLVGL
                     NDHFYMGAGIAIVKELIFIAIFYLGTYYILRNKVNLL"
     gene            complement(7383..8582)
                     /locus_tag="VVO18_001010"
     CDS             complement(7383..8582)
                     /locus_tag="VVO18_001010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245382.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586187.1"
                     /translation="MRNMWVVIKETYLRHVESWSFFFMVISPFLFLGISVGIGHLQGS
                     SMAKNNKVAVVTTVPSVAEGLKNVNGVNFDYKDEASAKEAIKEEKLKGYLTIDQEDSV
                     LKAVYHGETSLENGIKFEVTGTLNELQNQLNRSTASLSQEQEKRLAQTIQFTEKIDEA
                     KENKKFIQTIAAGALGFFLYMILITYAGVTAQEVASEKGTKIMEVVFSSIRASHYFYA
                     RMMALFLVILTHIGIYVVGGLAAVLLFKDLPFLAQSGILDHLGDAISLNTLLFILISL
                     FMYVVLAAFLGSMVSRPEDSGKALSPLMILIMGGFFGVTALGAAGDNLLLKIGSYIPF
                     ISTFFMPFRTINGYAGGAEAWISLAITVIFAVVATGFIGRMYASLVLQTDDLGIWKTF
                     KRALSYK"
     gene            complement(8579..9472)
                     /locus_tag="VVO18_001011"
     CDS             complement(8579..9472)
                     /locus_tag="VVO18_001011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895295.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586188.1"
                     /translation="MLEVRSLEKSFGSKQVLFGIDFQARPGRILGLVGKNGAGKTTIF
                     HSILKFLEYQGEIGLDGQDIRQETYARIGYLPEERSLMPKLTVLEQVRYLATLKGMDA
                     KEVKEKLPQWMKRLEVKGKLTDKIKSLSKGNQQKIQLIITLIHEPDLIILDEPFSGLD
                     PVNTELLKQVIFQEKERGATIIFSDHVMTNVEELCDDILMIRDGRVVLHGPVQDVRNQ
                     YGKTRLFVSSERSKEELENLPHVKQVSLTKQGSWKLILEDESAGRELFPILTQGQYIA
                     TFDQQAPTIDEIFKLESGVEV"
     gene            9589..9669
                     /locus_tag="VVO18_001012"
                     /pseudo
     CDS             9589..9669
                     /locus_tag="VVO18_001012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            10154..10373
                     /locus_tag="VVO18_001013"
                     /pseudo
     CDS             10154..10373
                     /locus_tag="VVO18_001013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153868.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            10788..11405
                     /locus_tag="VVO18_001014"
     CDS             10788..11405
                     /locus_tag="VVO18_001014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="HEU5586189.1"
                     /translation="MSQDKQMKAVSPLLQRVINISSIVGGVGSLIFCIWAYQAGILQS
                     KETLSAFIQQVGIWGPPLFIFLQILQTVVPIIPGALTSVAGVFIYGHIIGTIYNYIGI
                     VIGCAIIFYLVRLYGAAFVQSVVSKRTYDKYIGWLDKGNRFDRFFIFMMIWPISPADF
                     LCMLAALTKMSFKRYMTIIILTKPFTLVVYTYGLTYIIDFFWQML"
     gene            complement(11725..12612)
                     /locus_tag="VVO18_001015"
     CDS             complement(11725..12612)
                     /locus_tag="VVO18_001015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000164317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ROK family protein"
                     /protein_id="HEU5586190.1"
                     /translation="MTKLYGSLEAGGTKFVCAVGDENFNVVEKTQFPTTTPIETIDKT
                     IEFFSKFDNLAGLAVGSFGPIDIDKNSKTYGFITTTPKPNWANVDLLGALRRALNVPM
                     YFTTDVNSSAYGEVVARNNAGGRIENLVYYTIGTGIGAGVIQRGEFIGGVGHPEMGHY
                     YVARHPMDIEKEFKGVCPFHKGCLEGYAAGPSLEARTGVRGETIELNNPVWDVQAYYI
                     AQAAVNATVTFRPDVIVFGGGVMAQQHMLDRVREKFTSLLNGYLPVPDVRDYIVTPAV
                     AGNGSATLGNFVLAKEVSK"
     gene            complement(12761..14644)
                     /locus_tag="VVO18_001016"
     CDS             complement(12761..14644)
                     /locus_tag="VVO18_001016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864794.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU5586191.1"
                     /translation="MNNQEIAKKVIDALGGRENVNSVVHCATRLRVMVKDEEKINKEV
                     IENLEKVQGAFFNSGQYQIIFGTGTVNKMYDEVVVLGLPTSSKDDMKAEVAKQGNWFQ
                     RAIRTFGDVFVPIIPVIVATGLFMGVRGLFNALEMPLPGDFATYTQILTDTAFIILPG
                     LVVWSTFRVFGGNPAVGIVLGMMLVSGSLPNAWAVAQGGEVTAMNFFGFIPVVGLQGS
                     VLPAFIIGVVGAKFEKAVRKVVPDVIDLLVTPFVTLLVMSILGLFVIGPVFHVVENYI
                     LIATKAILSMPFGLGGFLIGGVHQLIVVSGVHHIFNLLEVQLLAADHANPFNAIITAA
                     MTAQGAATVAVGVKTKNPKLKTLAFPAALSAFLGITEPAIFGVNLRFRKPFFLSLIAG
                     AIGGGLASILGLAGTGNGITIIPGTMLYVGNGQLPQYLLMVAVSFALGFALTYMFGYE
                     DEVDATAAAKQAEVAEEKEEVAPAALQNETLVTPIVGDVVALADVNDPVFSSGAMGQG
                     IAVKPSQGVVYAPADAEVSIAFPTGHAFGLKTRNGAEVLIHVGIDTVSMNGDGFEAKV
                     AQGNKVKAGDVLGTFDSNKIAAAGLDDTTMVIVTNTADYASVAPVATGSVAKGDAVIE
                     VKI"
     gene            15021..16475
                     /locus_tag="VVO18_001017"
     CDS             15021..16475
                     /locus_tag="VVO18_001017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEU5586192.1"
                     /translation="MEWTTERRYRLYQDWTQEEIQHIKENMAQSPWHTHYHVEPKTGL
                     LNDPNGFSYFDGKWILFYQNFPFGAAHGLKSWAQLESDDLIHFKETGIKVLPDTPLDS
                     HGAYSGSAMQFGDNLFLFYTGNVRDENWIRHPYQIGALMDKEGKITKIDKILIDQPAD
                     STDHFRDPQIFNFKGQYYAVVGGQDLEKKGFVRLYKAVNNDYTNWQAVGDLDFANDRT
                     AYMMECPNLVFIEEQPVLLYCPQGLDKKVLDYDNIFPNMYKIGASFDPKNAKMVDVSQ
                     LQNMDYGFEAYATQAFNAPDGRALAVSWLGLPDVSYPSDRFDHQGTFSLVKELTIKDD
                     KLYQYPVAAIKDLRASEEAFSNRSQTKNTYELELNLEANSQSEIVLLADKEGKGLSIN
                     FDLVNGQVTVDRSQAGEQYAQEFGTTRSCPIENQATTATIFIDNSVFEIFINKGEKVF
                     SGRVFPHADQNGILIKSGNPTGTYYELDYGRKTN"
     gene            16456..17421
                     /locus_tag="VVO18_001018"
     CDS             16456..17421
                     /locus_tag="VVO18_001018"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002929307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5586193.1"
                     /translation="MVAKLTDVAKLAGVSPTTVSRVINKKGYLSEKTIQKVNEAMREL
                     GYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDS
                     EKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAG
                     GVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKE
                     MEIKNILTREKPDAIFASDDLTAILIIKIAQELGISVPKELKVIGYDGTYFIENYYPQ
                     LATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI"
     gene            complement(17456..18730)
                     /locus_tag="VVO18_001019"
     CDS             complement(17456..18730)
                     /locus_tag="VVO18_001019"
                     /EC_number="1.1.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000704367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA reductase,
                     degradative"
                     /protein_id="HEU5586194.1"
                     /translation="MKISWNGFSKKSYQERLELLKAQALLSPERQASLEKDEQMSVTV
                     ADQLSENVVGTFSLPYSLVPEVLVNGQEYTVPYVTEEPSVVAAASYASKIIKRAGGFT
                     AQVHQRQMIGQVALYQVANPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVE
                     QIKGEPDFLVVYIHVDTQEAMGANMLNTMLEALKPVLEELSQGQSLMGILSNYATDSL
                     VTASCRIAFRYLSRQKDQGREIAEKIALASQFAQADPYRAATHNKGIFNGIDAILIAT
                     GNDWRAIEAGAHAFASRDGRYQGLSCWTLDLEREELVGEMTLPMPVATKGGSIGLNPR
                     VALSHDLLGNPSARELAQIIVSIGLAQNFAALKALVSTGIQQGHMKLQAKSLALLAGA
                     SESEVAPLVERLISDKTFNLETAQRYLENLRS"
     gene            complement(18730..19902)
                     /locus_tag="VVO18_001020"
     CDS             complement(18730..19902)
                     /locus_tag="VVO18_001020"
                     /EC_number="2.3.3.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004181031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydroxymethylglutaryl-CoA synthase"
                     /protein_id="HEU5586195.1"
                     /translation="MTIGIDKIGFATSQYVLKLQDLAEARGIDPEKLSKGLLLKELSI
                     APLTEDIVTLAASASDSILTEQERQEVDMVIVATESGIDQSKAAAVFVHGLLGIQPFA
                     RSFEIKEACYGATAALHYAKLHVENSPESKVLVIASDIAKYGIETPGEPTQGAGSVAM
                     LITQNPRMMAFNNDNVAQTRDIMDFWRPNYSTTPYVNGVYSTQQYLDSLKTTWLEYQK
                     RYQLTLDDFAAVCFHLPYPKLALKGLKKIMDKSLPQEKKDLLQKHFDQSILYSQKVGN
                     IYTGSLFLGLLSLLENTDSLKAGDKIALYSYGSGAVAEFFSGELVEGYEAYLDKDRLN
                     KLNQRTVLSVADYEKVFFEEVNLDETNSAQFAGYENQDFALVEILDHQRRYSKVEK"
     gene            complement(20033..20236)
                     /locus_tag="VVO18_001021"
     CDS             complement(20033..20236)
                     /locus_tag="VVO18_001021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586196.1"
                     /translation="MNLIAEKVSKTLDKTFDKDVREIPTSQFYQKFVDEMGRTYSGNL
                     ILQELITVNGAYKATYIGELSSN"
     gene            complement(20222..20785)
                     /locus_tag="VVO18_001022"
                     /pseudo
     CDS             complement(20222..20785)
                     /locus_tag="VVO18_001022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(20847..21296)
                     /locus_tag="VVO18_001023"
     CDS             complement(20847..21296)
                     /locus_tag="VVO18_001023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEU5586197.1"
                     /translation="MTLTTFLLQAVASFLAIITFLIVLNVQRSMLLPGGILGMTVWLI
                     YLLLKEPTNVIVATFIAAIIGSCVSQILSILYKTPAVVFILAILAPLVPGYLSYRTTA
                     FFVTGDYNKALASATLVVMLALVISIGMASGTVILRLYHYIKTHRVS"
     gene            complement(21298..22056)
                     /locus_tag="VVO18_001024"
     CDS             complement(21298..22056)
                     /locus_tag="VVO18_001024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine/serine exporter family protein"
                     /protein_id="HEU5586198.1"
                     /translation="MEESKELNAVIDVIMLAGTILLKSGSEIHRVEDTMIRIAHSQGI
                     VDCNVLAMPAAIFFSIENTNISRMKRVTSSSYNIEKVCDVNQISRQLVGGQIDLETAF
                     KQLTALQAQPLPYTKLQVTLAATFSAPFFSVMFSGNIYDALGAGVATLFGFAFSLYVE
                     KFIRIPFVTAFAGAFVFGIIAQFWARYTGFPSTADLIIAGAVMPFVPGIALTNAVRDI
                     MTNHINSGMSKMFESLLITLALGAGTSVALVLMN"
     gene            complement(22171..24150)
                     /gene="pknB"
                     /locus_tag="VVO18_001025"
     CDS             complement(22171..24150)
                     /gene="pknB"
                     /locus_tag="VVO18_001025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398866.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="HEU5586199.1"
                     /translation="MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVL
                     RTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYI
                     KEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
                     FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAV
                     TIALQHFQKPLPSVIAENPSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYN
                     RRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQ
                     APKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANF
                     EIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSD
                     VIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKAT
                     TIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVS
                     KPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAE
                     GMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP"
     gene            complement(24147..24887)
                     /locus_tag="VVO18_001026"
     CDS             complement(24147..24887)
                     /locus_tag="VVO18_001026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Stp1/IreP family PP2C-type Ser/Thr phosphatase"
                     /protein_id="HEU5586200.1"
                     /translation="MEISLLTDVGQKRTNNQDYVNHYVNRAGRTMIILADGMGGHRAG
                     NIASEMAVTDLGVAWVDTQIDTVNEVREWFAHYLEIENQKIHQLGQDEAYRGMGTTLE
                     VLAIIDNQAIYAHIGDSRIGLIRGEEYHQLTSDHSLVNELLKAGQLTPEEAEAHPQKN
                     IITQSIGQKDEIQPDFGTVILESGDYLLLNSDGLTNMISGSEIRDIVTSDIPLADKTE
                     TLVRFANNAGGLDNITVALVSMNEEDAE"
     gene            complement(24902..26215)
                     /gene="rsmB"
                     /locus_tag="VVO18_001027"
     CDS             complement(24902..26215)
                     /gene="rsmB"
                     /locus_tag="VVO18_001027"
                     /EC_number="2.1.1.176"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (cytosine(967)-C(5))-methyltransferase
                     RsmB"
                     /protein_id="HEU5586201.1"
                     /translation="MTKVETARSLALAVLEDVFVNQAYSNIALNKHLKGSQLLAADKG
                     LVTELVYGTVARKLTLEWYLSHFIEDRDQLDSWLYVLLLMSAYQLRYLDKIPDHAVVN
                     EAVELAKLRKKGSEKLVNALLRRILREGWPDISSIKRKNKRDSIAYSLPVWLVAKLKE
                     EYGEERAKAIFESLLVRNKASIRVTDLSRKEEIQALLEANNSLLATTGLVKEQGHFAG
                     HNLFADGAITIQDESSQLVAPTLDLQGDERVLDACAAPGGKTAHIASYLTTGQVTALD
                     LYDHKLDLIQENAQRLGVEDRVQTQKLDARKVHEFFDQDSFDKILVDAPCSGIGLLRR
                     KPDIKYNKETADFASLQEIQLEILGSVCQILGKGGIITYSTCTIVSEENFQVVKAFLE
                     SHPEFEQVKLEHECKDIMKDGCILITPELYGSDGFFISQFRKISD"
     gene            complement(26208..27143)
                     /locus_tag="VVO18_001028"
     CDS             complement(26208..27143)
                     /locus_tag="VVO18_001028"
                     /EC_number="2.1.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="HEU5586202.1"
                     /translation="MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKV
                     IQETPVKQAAKEAGLSIYQPEKLSGSPEMEDLMKLGADGIVTAAFGQFLPSKLLDSMD
                     FAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDED
                     NVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKPEEEKLDWNKTN
                     RQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSIGKKELIVATAEGA
                     LSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD"
     gene            complement(27156..29552)
                     /locus_tag="VVO18_001029"
     CDS             complement(27156..29552)
                     /locus_tag="VVO18_001029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001162119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primosomal protein N'"
                     /protein_id="HEU5586203.1"
                     /translation="MALAKIIVDVPLMQTDQPYSYRIPEEFEGMLEVGMRVHVPFGKG
                     NRLIQGIVLGLESQSDGEEMEQDLKDIAEVLDFSPVLTPEQLWLAEELRKSVFSYKIS
                     ILKAMLPGFLNSSYDKILYPLEGLSQEERVRLFGSEDSLAFSSLDLAKQAEMMRLTRK
                     GLLVLEYQAVDQKKVKTQSWYEVDHAQLEGVEISTRAKKKLELRDYLLSHPESASLAS
                     LLESYSREQVNFFVDQGAVTIVQKEVQRSAAYFEGIEASRPLELNPEQRQARDAVVSS
                     IGSSQPPFLLQGITGSGKTEVYLQIIQGALDKGKTAILLVPEISLTPQMTERFIARFG
                     DKVAILHSGLSNGEKYDEWRKVERGDAQVVVGARSAIFAPLKNLGVMIIDEEHEAAYK
                     QDSNPRYHAREVAILRAQYNQATLVLGSATPSLESRARAGKGVYQHLRLTQRANPLAT
                     IPEVQVIDFRDYIGQNETSNFTPPLLEAIQDRLVKKEQVVLMLNRRGYSSFVMCRECG
                     TVDTCPNCDISLTLHMDTKTMNCHYCGFSKDIPQVCPNCKSRSIRYYGTGTQKAYDEL
                     AELFPQARILRMDVDTTRKKGSHQALLDQFGRGEADILLGTQMIAKGLDFPNVTLVGV
                     LNADTALNLPDFRSSERTFQLLTQVAGRAGRAEKAGQVLIQSYNSQHYAIRFAKDQDY
                     EGFYAYEMGIRRQLGYPPYYFTIGITLSHKKEEEVFKRAYEVMNILRSGLSETSPILG
                     PTPKPIARTHNLYHYQILIKYRLEDELGPTLNQVLALTQERENSELRLSIDHEPQQFL
                     "
     gene            complement(29618..29932)
                     /locus_tag="VVO18_001030"
     CDS             complement(29618..29932)
                     /locus_tag="VVO18_001030"
                     /EC_number="2.7.7.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817694.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-directed RNA polymerase subunit omega"
                     /protein_id="HEU5586204.1"
                     /translation="MMLKPSIDTLLDKVPSKYSLVILEAKRAHELEAGAPATQGFKSE
                     KSTLRALEEIESGNVTIHPDPEGKREAVRRRIEEEKRRKEEEEKKIKEQIAKEKEDGE
                     KI"
     gene            complement(29957..30583)
                     /gene="gmk"
                     /locus_tag="VVO18_001031"
     CDS             complement(29957..30583)
                     /gene="gmk"
                     /locus_tag="VVO18_001031"
                     /EC_number="2.7.4.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775037.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="guanylate kinase"
                     /protein_id="HEU5586205.1"
                     /translation="MADRGLLIVFSGPSGVGKGTVRREIFESSENQFQYSVSMTTRAQ
                     RPGEVDGVDYFFRTREEFEELIRQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLE
                     IEVQGALQVKKKVPDAVFIFLTPPDLDELQDRLVGRGTDSAEVIAQRIEKAKEEIALM
                     REYDYAIVNDQVSLAAERVKCVIEAEHFCVDRVIGHYQEMLPKSPTTR"
     gene            complement(30713..32326)
                     /locus_tag="VVO18_001032"
     CDS             complement(30713..32326)
                     /locus_tag="VVO18_001032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520539.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease Y"
                     /protein_id="HEU5586206.1"
                     /translation="MEIMSLAIAVFAVIIGLVIGYVSISAKMKSSQEAAELMLLNAEQ
                     EATNLRGQAEREADLLINEAKRESKSLKKEALLEAKEEARKYREEVDAEFKSERQELK
                     QIESRLTERATSLDRKDDNLTSKEQTLEQKEQSISDRAKNLDAREEQLEEVERQKEAE
                     LERIGALSQAEARDIILAQTEENLTREIASRIREAEQEVKERSDKMAKDILVQAMQRI
                     AGEYVAESTNSTVHLPDDTMKGRIIGREGRNIRTFESLTGVDVIIDDTPEVVTLSGFD
                     PIRREIARMTMEMLLKDGRIHPARIEELVEKNRQEIDNKIREYGEAAAYEIGAPNLHP
                     DLMKIMGRLQFRTSYGQNVLRHSIEVAKLAGIMASELGENAALARRAGFLHDIGKAID
                     HEVEGSHVEIGMELARKYKEPPVVVNTIASHHGDVEAESVIAVIVAAADALSAARPGA
                     RSESLESYIKRLHDLEEIANGFEGVQTSFALQAGREIRIMVNPGKIKDDKVTILAHKV
                     RKKIENNLDYPGNIKVTVIRELRAVDYAK"
     gene            complement(32595..>32767)
                     /locus_tag="VVO18_001033"
     CDS             complement(32595..>32767)
                     /locus_tag="VVO18_001033"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000388575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="type II toxin-antitoxin system
                     prevent-host-death family antitoxin"
                     /protein_id="HEU5586207.1"
                     /translation="NDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDK
                     VLRGMDKIRAGH"
BASE COUNT         9194 a         7503 c         6343 g         9727 t
ORIGIN      
        1 gtaccataag ccacctccta caaatagaaa ccgatataaa tcaatgcctt ccacccttag
       61 acttccctag ttcctgtctc aagcgaaaca tttctttgaa acaggaataa gttaaccaat
      121 tcataccaat agctagcaga ataaaaagaa accaaatgcc ccataacttg atatctgtca
      181 catttctcaa gacggtattg aaaaacagaa ctgaaacaac tgtccaagca aggctaaaaa
      241 gagaatagaa ggggatgtaa aaccagtaaa aataataaaa aattggaaaa aacttactat
      301 ttctgttggc cttttcaatc cagttatcaa aataaaagta cggtgctaaa agtaagaatt
      361 taaacaaatg ttccatcacc gacatcaccc tccttctttt gatagcgttt tctattattt
      421 tattatatca aaaaaatccg gaactgtcat tccagattct acttttttat ttgcgttttc
      481 ttgcgatgag atgaatcggt gttccctcaa aaacaaaggc cttgcggatt tgattttcca
      541 agaaacgcag gtaagaaaag tgcatgagtt cttcttcatt gacaaagatg acaaaggttg
      601 gtggtttggt tgccacttgg gtcgcataga aaatcttgag acgttttcct ttgtctgtcg
      661 gtgttgggtt gatggcaatg gcatccatga tgacatcgtt caagacagct gatggaatac
      721 gtgtattttg actttcgctg atttgcttaa tcatctcagg aagtttgtgg agacgttgct
      781 tggttaaagc tgatacaaag ataatcggtg cgtaaggcag gtattggaac tgctcacgga
      841 tatcttcttc ccagtttttc atagtgtggt tatctttttc aagcgtatcc cacttgttga
      901 ccacgataat catcccttta ccagcttcat gggcaaatcc tgcgatacgc ttgtcgtact
      961 cacgaatgcc ttcttccgca ttgatgacca tcaagaccac atctgaacgg tcaatagcac
     1021 gcatggcacg cataacagag tatttctcag tattttcata aaccttacca gacttacgca
     1081 taccagccgt atcaatcatg gtaaactctt gaccatctgt atctgtaaag tgggtatcaa
     1141 tggcatcacg agttgttcca gcaacaggac tagcaataac acggtcttcg cccaagatag
     1201 cattgatcaa gcttgatttt ccaacgtttg gacgaccaat caggctaaac ttaatgacat
     1261 ctggattttc ttcttcatat tcatttggaa ggttttccac aatcgcatct agtacatccc
     1321 ctgtaccgat accatggaca gatgagatag gcagtggttc acccaaaccg agggcataga
     1381 aatcatagat atcatttcgc atctcagggt tgtccacctt gttaactgcg aggataactg
     1441 gtttgtgggt cttataaagc ttacgggcta cgtattcgtc tgcatcggta attccttcct
     1501 taccggacac gacaaagacg ataacatctg cttcttccat ggcaatttct gcctggtgct
     1561 tgatttgttc catgaaagga gcatcgacat catcaattcc tcctgtatca atcatgctaa
     1621 aagaacgatt gagccactca cccgttgcat aaatacggtc acgtgtcact ccttcgacat
     1681 cttctacaat ggagattcgc tcaccagcga tccgattaaa tagggttgat ttcccaacat
     1741 tgggacgtcc tacaatggca atagttggta gggccataat ttctcacttt ctacaataat
     1801 ttcttctgtt caagattttt tctagttgag cttggttcag cttgaccaaa ctgttctgct
     1861 aggcgctgac tccagcttgt ggtcgcacgc gccccagcat agtcagcctg aacacggtca
     1921 taagcttgga ttgcctcagt tgactgttct tggtattctt cctcaaagac aacattctct
     1981 agtggcagtc tcggtttcat atcatgatgt tgatttggca cacccagtgc catcccaaag
     2041 acagaatagg tgtagtcagg caggttaaag agctctgcca cttcttcaga cttgtatcga
     2101 accaaaccga taatcacacc accatagccc aagctttcag ctgccaacaa ggcgttttgt
     2161 ccagcaagag ctgcaccgac cgaactaatc aagagacctt ccacaccttg gggttggaag
     2221 gtgtcggtat gaagtcgggc tcccttttct gctcggttca aatctccgac aaagagaagg
     2281 aaaacagcag actggcgaat ggcttcttga ggtaccaatt catacaaggc atctttcttc
     2341 tcttgacttc gtaccacaat cacagagtag gattggaaat tcttccaaga tgatgccatc
     2401 tgggctgctg tcaaaatctc atttaagtct acttggggaa tttcttgctc tttaaacctg
     2461 cgcactgaag tatgagcctt catcaattta atggtttctg tcatcgacgg tttactcctt
     2521 ctaaacgagt ctcctcagcc aaataacgga tgcgttccat gacccgtctg gcttcccagg
     2581 tttcgtcatt tccatgtttc actttcgcaa aatgcttctc caaatcttca aagttgaagt
     2641 tggatgtgaa aaaggtcggt aaattttcct gcatccgata ttggagaatg acctgcagga
     2701 tttcgtcacg cacccaaacg gttgattgct cggcgccaat atcatctaaa atcaggacct
     2761 cagacagctt aatctcatcc accaaggtct taacattgcc atcactgata gcatttttga
     2821 catcaatgac aaagctagga tagtggagga gagttgatga aacaccacgt ttttctgata
     2881 aatcatgagc taaggccgcc accatgaaac ttttacccac accaaagtct ccatataagt
     2941 aaagaccttt tcgaatagct ggatattgct ccacgaaggc tagtagcttt tcaaaaactg
     3001 gtaagcgccc caaatcatcc aagtcaactt gagccaaact agctttcttg agactggctg
     3061 gtagattgat taacttgaga cggttcttaa tagccgcttc tttttcagcc gcgattagct
     3121 caggagtttc ttcatatgaa acatctgcat agccatgatt cttaaccaaa atcggcttgt
     3181 agcctttggc aatataatcc gtatccccac ggagaaactt gtcacgctcg gtgatgtact
     3241 gattaaactt ggagatactg cgatttaatt cctctggagt caaggattct tgctggataa
     3301 aagccgcaac atcagggtcc ttcatgattt tctggaccaa atcttgataa taaaaacggc
     3361 tgggttgacg tttgagtacg tctccgacac tttccatcta atctcctcct ttttctaatc
     3421 gagctaatag ttcttgcttc ttacgttcta gttccagacg agtttcctcg ctggtttcat
     3481 tcttatattc aggattactc catttaggaa cattggtttt tactggggca gtctgattct
     3541 gtttttgtgt ttttgctttc tgtcctcgct cacggatgcg caagactgcc ttttctgccg
     3601 aatgaatctt ttgataggca tagtcattgg ctaccttcat ggcatatttc tcattgatat
     3661 ttgccgaatc gaccttatta aaggtcaata aaagaatgat attgatgact tcgtccagca
     3721 agcccaagcc agccatctgt tgcaagagtt ctctttctgt ttgggtaatg gttcccttgc
     3781 gtgtttgctt gatttctgcc aagaactgca gggcagtttt acttttagct tccttgataa
     3841 tggttgtttc cttaggacta aagtccgagg aaactggttt ttgagcaatt ttttcccgca
     3901 tgcgtttggt tgaaataacc tgggaaacag ctgttgactt ggccaattga taggtctcaa
     3961 accaagtcca cttcttctcc tcagcaatag caaacaagtt caagacatca gactgctcat
     4021 ccgcaaaacg aagtccatct cgagccatca gctgacgaaa atgatccaag tcaaaatcat
     4081 tggccacttt cttcttgaga ccaaggtctt cttgactgcc tagttctgcc aattctggaa
     4141 agacttgatt gagtgagaca ggtatttctt caccatcagc actttcaact ttcaaatcct
     4201 ccacagcaga gtcgccaatc tttttctcta agagtctgcg ataaacagga tgccccaaga
     4261 agtcttgact agatagagga gcatggaggg ctaactgata aacatccccc ttttgataga
     4321 gggtcaagag attaaaagca gataagattt tcaatgattt tatcagtcta tccatcccaa
     4381 agttgagatg attgaggata cttgaaaaaa gatattcctt tctaccatta tcccaaaaac
     4441 tgattgtata aagataaagg ctcagtgcct cctgaccgat aatcgggagg tagcactgta
     4501 ccagagatga ggtatcttgc gacacccgat tattctttag ataagaaaaa cggtcaattg
     4561 gcttcattta tctttccttt ttctttttag aggactgggt gatttgttgg agcaagctct
     4621 ctaactcact gacatcctta aaactacgat agacactagc aaaacgtaca taggtaatct
     4681 cgtccaattc agccaactcc tccatgacga gtgaaccaat gtcctcactt tgaatttcat
     4741 tttcatttcg accacggagt ttctgttcga tacgattgac taccatgttg atttcatcac
     4801 ttgacacagg acgtttctgg gctgagcgga taatcccatt aaagatttta tctctggaga
     4861 attgttcccg tgtgccatct tttttaacaa ccactaaggt tctttcttct actcgttcgt
     4921 aggttgtaaa acggtgttgg cactcgtcgc actctcgtct tctacgaatg gtgttccctt
     4981 cttctgcttg gcgactatcg ataacacttg acttggtagc cccacatttt ggacaacgca
     5041 tcctttccct ccttatcgtt ttcttttcat tataccattt tttaagcgat tcccaaaaca
     5101 attcttcttt ttgcttgaca agttttttgt tttgttgtat tatttaatta agacaaaaga
     5161 ataagagaaa ggagactaag atgtcctgga catttgacaa caaaaaaccc atctatttac
     5221 agattatgga gaaaatcaag cttcagattg tttcccatac actggaaccc aatcaacaac
     5281 ttccaaccgt gagggagcta gctagcgagg ctggtgtcaa tcccaatacc atccaaagag
     5341 ccttatcaga ccttgaacga gaaggatttg tctacagcaa gcgaacaact ggacgatttg
     5401 tgactaagga taaggagcta atcgctcagt cacgcaaaca attatcagaa gaagaattgg
     5461 aacacttcgt ttcctccatg acccattttg gctatgaaaa agaagaacta ccaggcgtag
     5521 tcagtgatta tattaaagga gtttaagcct atgtcattac tagcatttga aaatgtatcc
     5581 aaatcatatg gagcaacacc agcccttgaa aatgtttctc ttgacattcc agctggaaaa
     5641 attgtcggcc ttcttgggcc aaacggctca ggaaaaacaa ccctgattaa actaattaat
     5701 ggcctcttac aaccagatca aggacgtgtc ctcatcaacg acatggaccc aagcccagca
     5761 accaaggccg ttgtagctta tttgcctgat acgacctatc tcaatgagca aatgaaggtc
     5821 aaagaagccc taacctactt caagaccttc tataaagatt tcaatcttga acgcgctcat
     5881 catctacttg cagacctggg cattgatgaa aatagtcgtc tcaagaaact atcaaaagga
     5941 aacaaagaaa aggttcaact gattttggtt atgagccgtg atgctcgtct ctatgttttg
     6001 gatgaaccca ttggtggggt ggatccagca gcccgtgctt atatcctcaa taccattatc
     6061 aacaactact caccaacttc taccgttttg atttctaccc acttgatttc tgatatcgag
     6121 ccaatcttgg atgaaattgt cttcctaaaa gacggaaaag tcgtccgtca aggaaatgta
     6181 gatgatattc gctacgagtc aggtgaatcc attgaccaac tcttccgtca ggaatttaag
     6241 gcctaagcaa aggagattat ttatgttttg gaagttagtt cactacgaat ttaaaaatgt
     6301 taacaagtgg tatttagccc tctacgcagc cgtgctagtc ctttctgccc tcatcggaat
     6361 acagacacaa ggctttaaaa atctacctta ccaagaaagt caggctacta tgctactttt
     6421 tctagctaca gtctttggtg gcttgatgct tacacttgcg atttcaacca ttttcttgat
     6481 tattaaacgc ttcaaaggta gtgtctacga ccgacaaggc tatctgactt tgaccttgcc
     6541 agtttctgaa caccatatca tcacagccaa actaatcggt gcctttatct ggtcattgat
     6601 tagcaccgct gtattggctc taagtgctgt tattattctg gctttaacag ctccagaatg
     6661 gattcctctt tcttatgtga ttacatttgt agaaacacat ctccctcaga tctttcttac
     6721 aggtatatcc ttcctactaa ataccatttc aggaatcctc tgcatctacc tggctatttc
     6781 cattggacag cttttcaatg aataccgtac agcactcgct gttgcagcct acattggtat
     6841 ccaaatcgtc attggattta ttgaactttt cttcaatctt agttctaatt tctatgtcaa
     6901 ttcactggta ggactcaatg accatttcta tatgggagca ggtatagcca ttgttaaaga
     6961 actcatattc atagctatct tttatctcgg aacctactac atcttgagaa ataaggttaa
     7021 tttgctttaa ataattttta cctagatatg taacatactc atagaacaaa agagaccagg
     7081 caaaaagtct ttaaaattag aaaacgcata gtatcaagtg ttaaaaatcc ttgatattat
     7141 gcgttttttg tgagttgact tatttccttt cactatatcg caaaatgaaa taagaacgga
     7201 acgatgggat tttggaattc aaatcaattt gtaagaatgt tttagaagta atattatcct
     7261 attccagatt cagttcacta tacaattgag ttttcaagca acttgtttac ataatgtgta
     7321 cataattagg ttcgtgattc cacccttttc acctttaaaa acctcgcttt cgcaaggctc
     7381 ttctatttat aagataaggc acgtttaaag gttttccaaa tccctaaatc atccgtttga
     7441 agaacgagac tagcatacat gcgtccgata aatcctgttg ctaccaccgc aaaaatcact
     7501 gtaatagcaa gtgaaatcca tgcttccgct ccccccgcat agccattaat cgttcgaaac
     7561 ggcataaaga aggtcgaaat aaagggaata taagaaccaa tcttcaagag gagattgtca
     7621 ccagctgcac ctagagctgt cactccaaaa aaaccaccca taatcaaaat catcaaaggc
     7681 gacaaggctt tccctgagtc ctcaggacga gaaaccatag atcctaggaa ggctgccaag
     7741 actacataca tgaaaagact gatcaaaata aagagcaggg tattcagtga gatagcatct
     7801 cccaagtgat ccaaaatacc agactgagcc aagaatggca aatctttaaa gagcaaaacg
     7861 gcagccagac cacctacaac atagatccca atatgcgtta aaatcactag aaacagagcc
     7921 atcatccgcg catagaaata gtgacttgcc cttatgctag aaaaaacgac ttccataatt
     7981 ttggtgcctt tttcactggc aacttcctga gctgttacac ccgcataggt aatcagaatc
     8041 atataaagaa agaatcctaa ggcacctgct gcaattgttt gaataaactt tttattttcc
     8101 ttggcttcat caatcttttc tgtgaattga attgtctgcg ctaagcgttt ttcctgctct
     8161 tgagacaagg aagcagttga acgattaagc tgattttgca gttcattgag tgtacctgta
     8221 acctcaaatt taattccatt ttcaagcgat gtttcgccat gataaactgc ctttagaaca
     8281 ctatcttctt gatcaatggt caaataacct tttaattttt cttctttaat tgcttctttg
     8341 gcacttgctt cgtctttata gtcgaagtta acaccattta cattcttcag tccttctgct
     8401 acagatggca ctgttgtcac tactgccact ttattatttt tagccataga agaaccttgg
     8461 agatgcccaa ttcctacaga gattcctaaa aagaggaacg gcgaaatcac cataaagaag
     8521 aaactccatg actcgacatg tcgaagatag gtttccttga ttacaaccca catatttctc
     8581 atacttccac tcctgattct agtttaaaga tttcatcgat agttggcgct tgttggtcaa
     8641 atgttgcgat atattgacct tgagtcaaga ttgggaagag ttcccttcca gcgctctcat
     8701 cctccaaaat caatttccaa ctgccttgtt tggtcaagct cacctgtttg acatgaggaa
     8761 gattttccaa ttcttccttg cttcgttcac ttgaaacaaa gagacgcgtt ttcccgtatt
     8821 gattgcggac atcctgaact ggtccgtgca agaccacacg gccatctcgg atcatcagaa
     8881 tatcgtcaca aagttcctca acattggtca tgacatggtc agaaaagata atggttgctc
     8941 cgcgctcttt ttcctgaaaa atgacttgtt tgagcaattc tgtattaact gggtccaatc
     9001 cactaaaagg ctcatccaag ataatcaggt ctggttcatg aatcagagta ataatgagct
     9061 gaatcttctg ctgatttcct tttgacagac tcttgatttt atctgtcagc tttcctttca
     9121 cttccaacct cttcatccat tgagggagtt tttctttgac ttctttggca tccatgcctt
     9181 ttagagtcgc caagtagcga acttgttcaa gaactgtcaa tttaggcatg agactgcgtt
     9241 cttcaggcag ataaccaatc cgagcatagg tctcctgacg aatatcctga ccatccagac
     9301 cgatttctcc ctgatattct aggaatttca aaatactatg gaaaatcgtt gtttttccag
     9361 caccattttt tccgactagt cccaaaatac gacctggtcg cgcttgaaag tcaataccaa
     9421 acaaaacttg cttggatcca aaacttttct ctagacttct tacttctagc atctttcacc
     9481 tccgaaattt ctttcactca ttatactcct ttttgatagc ctttacaatg atttctgtcc
     9541 atttttagaa gactattgct gtgtaaaata tagcctggag cacttttata ctcaatgaaa
     9601 agcaaagagc aaactaggaa gctagtcgta ggctgctcaa agtacagctt tgaggttgca
     9661 gataaaactg acgaagtcag ctcaaaacac tgttttgagg ttgtggatag aactgacgaa
     9721 gtcagtaact atatctacag caaggcgaag ctgacgtggt ttgaagagat tttcgaagag
     9781 tattagtgat aaatccatta tacagtagca aactcaattt ataccttccg ctcctcaact
     9841 gtctattttt aatcctgaat tgttatttga gtaactcctt tttcctcata aagttttctt
     9901 cctctaaaac ttctggaaaa aggcgaatag tttcagacaa catttttata agaaacaagt
     9961 tcatctgtca tttcaagaag gagtaatcct ttatttacta atggacggaa cggaattcaa
    10021 ccgcttgtcc gatatgtttt ctaaggatta tatagtaaaa tgaaataaaa acaggacaaa
    10081 tagatcggga cagtcaaatc gatttctaac aatgttttag aagtagatgt atactattct
    10141 agtttcaatc tgctatatct attatgcaca cccctatagg atctaatgaa aatcacaaca
    10201 ggctcattca tagatggtta cctaagccta agggaactaa gaaaacgact acaaaggaag
    10261 tcgcattcat cgaaaagtgg attaacaact atcctaaaaa atgcttgaac tacaagtccc
    10321 ccagagaaga cttctggatg actaacttga acttgaaatt tagcaataat taattcacca
    10381 tctaactata tttagtaatt atttcagaac tgattaatat taaaattaac taacgattca
    10441 aaggattcat actagccata aattacgtcc atcagagaga gactcttact acttttagat
    10501 tttagtcttt ctagcttcag aatacatcta aactttaggg aaaatgacta ttcgaaagcg
    10561 cgaatgcctc aaaattatct cagataagct attcgaaact tagaatgctt ttaaatttat
    10621 ggaattgcga ttattcgaaa cctagaatgc atataacctt tagttgacag acctattcta
    10681 agtctcgaag ggctatttac tttctattcc ttatcaaaaa agactcattc cccctttctc
    10741 ctccaaaata tggtatagta gaaatatact atctatgagg agtttacatg tcacaggata
    10801 aacaaatgaa agctgtttct ccccttctgc agcgagttat caatatctca tcgattgtcg
    10861 gtggggttgg gagtttgatt ttctgtattt gggcttatca ggctgggatt ttacaatcca
    10921 aggaaaccct ctctgccttt atccagcagg taggcatctg gggtccacct ctctttatct
    10981 ttttacagat tttacagact gtcgtcccta tcattccagg ggccttgacc tcggtggctg
    11041 gggtctttat ctacgggcac atcatcggga ctatctacaa ctatatcggc atcgtgattg
    11101 gctgtgccat tatcttttat ctggtgcgcc tatacggagc tgcctttgtc caatctgtcg
    11161 tcagcaagcg cacctacgac aagtacatcg gctggctaga taagggcaat cgttttgacc
    11221 gcttctttat ttttatgatg atttggccca ttagcccagc tgactttctc tgtatgctgg
    11281 ctgccctgac caagatgagt ttcaagcgct acatgaccat catcattctg accaaaccct
    11341 ttaccctcgt ggtttatacc tacggtctga cctatattat tgactttttc tggcaaatgc
    11401 tttgacacgt aaaaaatccg tttggtttcc caagcggatt tttaaagcgt agattaacta
    11461 tagcttgata ctaaatatac tttggtatgg aaattatgca tatttttcga tagtgaggcg
    11521 aggacttacc tagcctttcc accgtgatag aaacacctga aatctaatgg tttcaggtgt
    11581 tcggaaactt tgagcctagt gtctcaaagt ttaggtatgg aatttcgaag aaagtcgcta
    11641 ccgtccgtaa tcacttaagg aaaggctcaa aaatattgtt ttcaaccaca aaatccgttt
    11701 ggtttcccaa gcggattttg tgctttattt tgaaacttct tttgcaagaa caaagttccc
    11761 aagtgtggca gaaccatttc ctgcgactgc tggcgtcacg atatagtcac gcacatctgg
    11821 tactggtagg taaccattaa gaagagatgt aaatttctca cggacacggt ccagcatatg
    11881 ttgttgagcc atgacccctc caccaaagac aatcacgtct gggcggaaag tcactgtcgc
    11941 attaaccgca gcttgagcga tatagtaggc ttgaacatcc caaacagggt tgttgagttc
    12001 aatagtttcc ccacgtacac ctgtacgagc ttccaaactt ggaccagctg catagccttc
    12061 cagacatccc ttatggaaag gacaaacacc cttaaactct ttttcaatat ccattgggtg
    12121 tctagcaaca taataatgac ccatttcagg gtgacccaca ccaccgataa actcaccacg
    12181 ttggatgacg cctgcaccga tacctgtacc gattgtgtag taaaccaagt tttcgatacg
    12241 accaccagca ttgttacggg caaccacttc accgtaagca gagctgttta cgtctgttgt
    12301 gaagtacatt ggcacgttta gggcgcgacg aagggcacca agcaagtcca catttgccca
    12361 gtttggtttt ggagtcgtcg tgataaagcc ataagttttt gagtttttgt caatatcaat
    12421 cggcccaaat gaaccaactg caagaccagc aaggttatcg aattttgaga agaactcaat
    12481 ggttttatcg attgtttcga ttggagttgt tgttggaaat tgtgtttttt ctacgacgtt
    12541 aaagttttca tcaccgacag cacagacaaa ctttgtaccg cccgcttcca agcttccata
    12601 taattttgtc atgataaacc tcttgttttt attttcttta ttatagcata cttcgaaagt
    12661 ctaaatgtct ctatttttta gattttcctc tgtaaatctt actatctaat aaaaacgaac
    12721 aaacatgtca tttgttcgtt ttcacattag agaggattga ttagattttc acttcgatca
    12781 cagcatcccc cttcgcaact gaacctgttg cgactggagc tactgaagcg tagtcagctg
    12841 tatttgtaac gataaccatt gttgtatcat caagtccagc tgcagcgatt ttgtttgagt
    12901 caaatgttcc aagaacatca ccagctttca ccttattacc ttgagcaact tttgcttcaa
    12961 aaccgtcacc gttcatagat acagtgtcaa taccaacgtg aatcaaaact tcagcaccat
    13021 ttcttgtttt caaaccaaaa gcgtgccctg ttggaaaggc aattgaaact tcagcatcag
    13081 ctggtgcata gaccacgcct tggcttggtt tcacagcgat accttgtccc atagctccac
    13141 ttgagaagac tgggtcattg acatcagcaa gagcgacaac atcaccgacg ataggagtta
    13201 caagtgtttc attttgaaga gctgctggcg caacttcttc tttttcttca gccacttcag
    13261 cttgttttgc agctgcagtt gcgtctactt catcttcgta accaaacatg taagtaagag
    13321 caaaaccaag ggcaaatgat acagctacca taagaaggta ttgtggaagt tgtccgttac
    13381 caacataaag cattgtacca gggatgatgg tgataccatt accagtacca gcaagtccaa
    13441 ggatagaagc caatccacca ccgattgcac cagcaatcaa tgaaaggaag aatggtttac
    13501 ggaagcgcaa gttcaccccg aagatagcag gctctgtaat acctaggaag gcagaaagag
    13561 cagccgggaa agcaagtgtt ttcagttttg gattttttgt tttaacacca accgcaacag
    13621 tagcagcacc ttgagctgtc atagcagctg tgatgatagc gttgaatggg ttagcatggt
    13681 cagcagcaag taattgcact tcaagcaagt tgaagatgtg gtgcacacct gacacgacga
    13741 tcaattggtg aaccccacca atcaagaaac caccaagacc aaatggcatg ctaagaatcg
    13801 cttttgtagc aataaggatg tagttttcaa caacgtggaa aactggtcca atgacaaaga
    13861 gtccaaggat agacatgacc aaaagtgtca cgaatggtgt taccaatagg tcaatgacat
    13921 ctggaacaac cttgcggaca gctttttcaa atttagctcc gacaaccccg atgatgaagg
    13981 ctggaagaac ggaaccttgc aaaccaacaa cagggatgaa accaaagaag ttcatcgctg
    14041 ttacttcacc accttgagca actgcccaag cgtttggaag tgagccagag acaagcatca
    14101 taccaagaac gataccaacg gcaggatttc caccaaatac acggaaggtt gaccacacaa
    14161 ccaaacctgg caagatgatg aaggctgtat ctgtcaagat ttgtgtgtaa gttgcaaagt
    14221 cacctggaag tggcatttca agagcgttga aaagaccacg cacacccatg aagagacctg
    14281 tcgctacgat aactgggatg attggaacga aaacatcacc gaaagtacgg atagcacgtt
    14341 ggaaccagtt cccttgttta gcaacttctg ctttcatgtc atccttagat gatgttggta
    14401 agccaagtac aacaacttca tcgtacattt tgttaactgt acctgtacca aagataattt
    14461 ggtattgccc tgagttaaag aaagcacctt gaactttttc caagttctca atcacttctt
    14521 tattgatttt ctcttcatct ttgaccatga cacgtagacg agtcgcacag tggacaacac
    14581 tattgacatt ttcacgtccg cccaaggcat cgatgacttt ttttgcaatt tcctgattgt
    14641 tcatttgcaa aaatctcctt atataacatt ttgttcttgt ttgaaagcga ttttattcgc
    14701 ccttacgact attattttat catgttttaa aaatatgtca agcgttttgc agaaaaaata
    14761 ttctatccac ttagtgggca agctttagat tgattgtttt tgactgtttc atcaggaatt
    14821 ccttgaaaaa taagtttgaa accttggtta aaaagtattt tatttcatta tctttcacat
    14881 tttcgtaaaa atttgattga tttcctgtat ttattttatg ataatcgttt gacagttttt
    14941 tctctttttt aatataaaag gcttgtattt tttatcgaaa acagttacta ttaaaagtga
    15001 taagattttt ggaggaatga atggaatgga caactgagcg tcgttacaga ctttatcaag
    15061 attggacgca agaagaaatt caacatataa aggaaaatat ggcacaatct ccatggcata
    15121 ctcattacca tgttgagcca aaaacaggac ttctcaacga cccaaatggc ttttcttact
    15181 ttgatggcaa gtggatcctc ttttaccaga attttccttt tggtgcagcc cacggtttaa
    15241 aatcttgggc acagctagaa agtgatgatt tgattcactt taaagaaact ggaatcaaag
    15301 ttttaccaga tactccatta gatagccacg gtgcctactc tggttctgcc atgcaatttg
    15361 gcgataactt attcctattt tatacaggaa atgttcgcga tgaaaactgg atccgtcacc
    15421 cataccaaat cggtgctttg atggacaagg agggtaagat tacaaagatt gacaagatct
    15481 tgattgacca gccagcagac tctactgacc acttccgcga tccacaaatt tttaacttta
    15541 aaggtcaata ctatgctgtc gtcggtggac aggacttgga gaaaaaaggc ttcgtccgtc
    15601 tctacaaggc tgtcaataac gactacacaa actggcaagc agttggcgac cttgactttg
    15661 ctaacgaccg tactgcctac atgatggaat gtcctaatct ggtctttata gaggaacaac
    15721 ctgtccttct ctactgtcca caaggattgg ataagaaagt tctagactac gataatatct
    15781 ttccaaatat gtataagatc ggggcttcct ttgaccctaa aaatgccaaa atggtagatg
    15841 tgtctcaact tcaaaacatg gattacggtt tcgaagccta tgcaactcaa gccttcaacg
    15901 ctcctgatgg gcgtgctcta gcagttagct ggcttggttt gccagatgtt tcttacccat
    15961 ctgaccgttt tgaccaccaa ggaaccttct ctttggtcaa ggaactcact atcaaagacg
    16021 acaagctcta ccagtatcca gtcgctgcta ttaaggacct tcgtgcttct gaagaagcct
    16081 tctcaaaccg ttcccaaacc aagaacactt acgaacttga actcaacttg gaagctaata
    16141 gccagagcga gattgtctta cttgctgata aagaaggtaa gggactttca atcaactttg
    16201 accttgtaaa cggtcaagtg acagtggatc gtagccaggc tggagaacaa tatgcccaag
    16261 aatttgggac aactcgttct tgccctatcg agaatcaggc tactactgct acaatcttca
    16321 tcgataactc tgtctttgaa attttcatca ataaaggaga aaaagtattt tctggtcgtg
    16381 tcttcccaca tgcggaccaa aatggtatcc tgatcaaatc tggaaaccca actggaactt
    16441 actatgaatt agattatggt cgcaaaacta actgatgtcg ccaaacttgc aggcgtcagt
    16501 cctactaccg tttctcgggt tatcaataaa aaaggatatc tatctgagaa aaccatccaa
    16561 aaagtcaatg aagccatgag agaattaggc tataaaccca acaacctggc tcgtagtctg
    16621 caaggaaaat cagctaagtt aatcggcttg attttcccca atatttccaa tgttttctat
    16681 gcagaattga ttgataaatt ggaacaccaa ctcttcaaaa atggttacaa gaccatcatc
    16741 tgcaacagtg aacatgattc tgagaaggaa cgcgaataca tcgaaatgtt ggaagccaat
    16801 caggtagacg gcatcatttc tggtagtcac aacctaggaa tcgaagacta caatcgtgtg
    16861 acagcgccga ttatttcctt tgaccgaaac ctatcgccag acatccctgt tgtctcctct
    16921 gacaactatg ctggtggggt tcttgctgcc caaaccttgg tcaagacagg tgcccagtct
    16981 atcatcatga ttacagggaa tgacaattcc aattcgccaa ccggactgcg ccacgctggt
    17041 tttgcatccg tactcccaaa agctcctatt atcaatgttt ccagtgactt ttctcccgtc
    17101 agaaaagaaa tggaaatcaa gaatatcttg acccgggaaa aaccagatgc catttttgct
    17161 tcggatgatt tgacagctat tctgatcatt aaaatcgctc aagaattggg catttctgtc
    17221 ccaaaagagc tcaaggttat cggctatgat gggacctact ttatcgaaaa ttactaccct
    17281 caattggcta ctatcaagca acctttggaa gagattgctt gtctcactat tgatcttctc
    17341 ttgcaaaaga ttgaaggcaa ggaagtcgcc acaactggtt acttcttacc agttacacta
    17401 ttaccaggaa aaagtattta aacacaagaa aactcagacc gattcgtctg agtttttatg
    17461 atcttaaatt ttcgagatag cgctgggctg tctctaggtt aaaggtttta tctgagatga
    17521 ggcgctctac taggggagca acttcagatt cactagcccc agctaggaga gctagggatt
    17581 tggcctgtag tttcatgtgg ccttgctgga tgcccgtact taccaaggct ttgagggctg
    17641 caaaattttg ggcaagaccg atggacacga taatctgggc taattctctg gcagaaggat
    17701 ttcctagtag atcatgactg agagctacac gtgggttgag gccgatagag ccacccttag
    17761 tcgctacagg catgggcagg gtcatctcac cgaccaattc ttctctttca aggtccagcg
    17821 tccagcaact aagaccttga tagcgtccat ctcgactggc aaaggcatgg gccccagctt
    17881 cgatggcacg ccagtcatta ccagtggcaa tcaaaatcgc atcaatacca ttaaaaattc
    17941 ctttattatg agtagcagct cggtaaggat cagcctgcgc aaactgacta gccaacgcaa
    18001 ttttctccgc aatctctcgt ccttgatcct tttggcggct caagtagcga aaggcgatgc
    18061 gacagcttgc agtcaccaga gaatcggtcg cgtagttgga caggattccc atgagactct
    18121 gtccctgact gagttcttct aagactggtt tcaaggcttc cagcatggtg ttgagcatat
    18181 tggcacccat ggcttcctgg gtatcgacat gaatataaac aacgagaaag tctggttcgc
    18241 cttttatctg ctcgacatgc agatcacgcg ccccacctcc acgtttaacg atagaaggat
    18301 aggcttgatt ggcaagctcc aagagctccg ctttcttgct ggcaatcttc tcttgcgcta
    18361 gtttaggatt agcaacttga taaagggcta cctgcccaat catctgtcgc tgatggactt
    18421 gtgcagtaaa accacctgca cgcttgatga ttttgctggc atagctggcc gccgcaacca
    18481 cagagggttc ttctgtcaca tagggaacgg tgtattcctg accgttgaca agtacctccg
    18541 gaaccagtga ataaggcaga gaaaaagttc ccactacatt ctcactcagc tggtctgcca
    18601 cagtcacgct catctgttca tccttctcca gactagcttg tctctcagga ctaaggagcg
    18661 cctgagcttt taacagctcg aggcgctctt ggtatgattt tttagaaaat ccattccaac
    18721 ttatcttcat tatttttcaa ccttgctata acggcgttgg tggtcgagaa tttcaaccaa
    18781 ggcaaaatct tgattttcat agccagcaaa ctgggcagag tttgtttcat ccaagtttac
    18841 ttcctcaaaa aagacctttt catagtctgc aacggataag acagttcgtt ggttgagctt
    18901 gttcaagcgg tctttatcca aataagcttc atatccttca accaattcac cactgaagaa
    18961 ctcagccaca gctccacttc cgtaactata aagggcgatt ttatccccag ctttcaagct
    19021 atctgtattt tccaagagag acaaaagtcc aaggaaaagt gaacctgtgt agatattccc
    19081 caccttttga ctgtagagaa tagactggtc aaaatgcttt tgtaagaggt cttttttctc
    19141 ttgaggcagg ctcttatcca tgattttttt caagcctttt agcgctaatt taggataagg
    19201 caagtggaaa caaacagccg caaaatcatc caaagtaagc tggtagcgtt tttgatattc
    19261 aagccaagtc gttttcaaac tatccaagta ttgttgggta gaatagacac catttacata
    19321 aggagttgtc gagtaatttg gtcgccagaa atccatgatg tcacgggtct gagctacatt
    19381 gtcattatta aaggccatca tgcgtggatt ttgtgtaatc aacatagcca cacttccggc
    19441 accctgagtg ggttctcccg gagtttcaat accgtatttg gcaatatcac ttgcaatgac
    19501 caagaccttg gactccggag aattttccac atgcaatttg gcataatgga gggcagcagt
    19561 cgccccatag caggcttctt taatctcgaa actacgagca aagggctgga tgcccagcaa
    19621 gccatgcaca aagacggccg cagccttact ctggtcaatt cctgactcgg tcgccacaat
    19681 gaccatgtca acttcttgtc tttcttgctc agttaaaata gagtcactag cactggccgc
    19741 caaggtcacg atgtcctcag ttaggggcgc aatactcaat tccttgagta agagtccttt
    19801 acttaatttt tcagggtcaa ttcccctcgc ttctgctaag tcttgtaatt tcaagacata
    19861 ttgactggtc gcaaaaccaa tcttatcaat accgattgtc atatttacct ctgttttatc
    19921 attcatgtaa aaaatcgttc tatactattt tatcacaaat ggcagtaaaa gagagaaaaa
    19981 agacttgatt caccaaatca agcctcttat tggtcatcat tttaaagaat gattagttgc
    20041 tagagagttc accgatataa gtagctttat aagctccatt cacagttatc agctcctgga
    20101 ggatcaaatt tcctgagtaa gtccttccca tctcatctac aaatttttga taaaactgac
    20161 tggtcggaat ttctctgaca tccttatcaa atgtcttgtc aagtgtttta ctaaccttct
    20221 cagcaatcaa attcattcgt aatccgaagc gtttacgatg atttcgatag gttgttgaaa
    20281 tcattttaaa cgtttttact ttggcaaaga tgttctcaac cttgcttctc tccttggata
    20341 gcgcatggtt ataggtttta tcttcagctg ttagtggctt gaggatatat cttcatgagc
    20401 ccttgataac cactgtcagc caagatttta ccagcttgtc cgatatttct gcaactcatt
    20461 ttgaacaact tcatatcatg acaatagttc acagtgatat ccaaagaaac aattctccct
    20521 tgacttgtga caatcgcttg agccttcata gcgtggcatt tctttttacc agaatcattc
    20581 gctaattctt tttttagggc gattgatttg tacttccgtc gcatcaatca ttaccgtgtc
    20641 ctcagaactg agaggagttc ttgaaatcgt aacaccacct ttgaacaaga gttacttcaa
    20701 cccattggct ccgacggagt aagttgcttt cgtggatacc aaaatcagcc gcaatttctt
    20761 cataagtgcg gtattctcgc acatatagaa agcgttgtta atttatttat ctcatttttc
    20821 agaaaattct tttatttctg taaagtctac gatactcgat gtgtttttat ataatgatac
    20881 agtctgagaa tcactgttcc gctagccatt ccaatagaga ttaccaaagc caacatgaca
    20941 accaaggtcg cacttgccag tgctttatta tagtcccctg tcacaaaaaa ggcagttgtt
    21001 cggtaggaga gataacctgg aaccagcggt gccaaaatgg ccaagataaa gaccacagca
    21061 ggtgtcttat aaagaatact taaaatctgg ctgacacaag aaccaataat ggctgcaatg
    21121 aaggtagcta caatgacatt ggtcggttcc ttgagcaaga gatagattag ccagacagtc
    21181 atgcccaaaa tccctccagg taagagcata gaccgttgca cattgagtac aattaaaaaa
    21241 gtgataatgg caagaaaact tgctactgct tgtaataaaa aggttgttag tgtcatatta
    21301 gttcatcaat accaaggcga cagaagttcc tgcccctaaa gcgagggtaa tgagcaggga
    21361 ttcaaacatc ttactcatac cagagtttat gtggttggtc ataatatcac ggaccgcatt
    21421 ggtcaaggca atacctggta caaacggcat gaccgcacca gctataatca aatctgccgt
    21481 tgaaggaaaa cctgtgtagc gagcccaaaa ctgggcaatt atcccaaaga caaaggctcc
    21541 agcaaaggct gtcacaaagg gaattcggat aaatttttcc acatagaggg aaaaggcaaa
    21601 accaaataag gtcgccactc ctgccccaag tgcgtcgtag atatttccgc taaacataac
    21661 tgaaaagaaa ggagcactaa aggtcgcagc cagagttacc tgcaacttag tatagggaag
    21721 gggttgagct tgcaaggccg tcaattgctt aaaggctgtt tctaagtcaa tctgcccccc
    21781 aactagctga cgagaaatct ggttcacatc gcagactttt tcaatgttat aagaagagga
    21841 ggtcacgcgc ttcatgcgcg aaatattggt attttcaata gagaaaaaga tagcggcagg
    21901 catggcaagg acattgcaat ccacaatccc ctgcgaatgc gcgattcgaa tcatggtatc
    21961 ttctacacga tggatttctg agccactttt aaggagaata gtccccgcta gcataatcac
    22021 atcaatgacg gcatttaatt cttttgattc ttccatgctt tcctcctttt atcaactccc
    22081 tctattctat cacaaatccg gactcaaaaa aaatctttgc catgaaatca tgacaaagat
    22141 tgattactca ttttgattat ccatctgctt ttaaggagta gctgaagttg ttttaggttt
    22201 gtagattgaa atcttgactc tagtcttatt gaggtctacc ttttcacctg ctctaggact
    22261 ttgttcaaca accatgcctt ctgcactacc tgcaggcgct gtcgtcactt ctacaacttc
    22321 tatattagct tccttaatcc caacaatttg aatcaaattg ttcttagtaa actccaagct
    22381 ggaaccaatg taactcggca tggcaacact tgtaactttt ttagctactg tcaagacaat
    22441 ttgagtaggt ttactcacat cataagtcgt tccggcacct ggactttgtt tcataatcgt
    22501 tcctggttcg ctttcgctgg actcttcttc ctctatctta atcaaattct caggaacctt
    22561 cttctgctta agttctgaga ttacttctgt agagttccgt ccaatatagt tccctaattg
    22621 aatcgtcgta gcttttttag ctactgtcaa aacaatttga gttgccttgc tcaagtcata
    22681 ggtcgtacct tctggtagac tttgcttcaa gaccgttcca gcctcactct cattcgactc
    22741 ttcttcctca attttaatca aattatctgg aacttttttc tcttttaatt ccgcgataac
    22801 atcagaagat ttccggccga cataattact aatttggaag gattgtttgc ctgatgagac
    22861 aaccaaattg attttcgttc cttcttttcg accagttcca gcgccaggat ctgtacggat
    22921 aatccgccct tcttccacct tttcactagc ctctgtcttc tcctcaccaa tctcaaaatt
    22981 ggcttttttg agcgttgcct tggcctctgc aactgtctga cctgccacat ctggaatggc
    23041 aatggttgca ggagttctgg atagtatcca aataagagaa gctgccacca atacaaggct
    23101 ggccaacaaa atcaggtaac gcatcttaaa tctatgtttt ttcggtgctt gtggttggta
    23161 agtttcctct gtcacagcct gacttgggtt tttgattgat ttgtgttctg tctgcgcttg
    23221 aaccttagga atagatgtca aggtactctg agaaaccttc ggcaaggtct tggtatctgc
    23281 cttgctcgtt tcatcaaaga ttaacttact ttcatttcta cgattgtagg acaagctact
    23341 agacaagtcc acatacatct ctgaaaccga gcggtagcga ttggtcaact ttttagcagt
    23401 tgccttgata ataacatttt ctaaagcctg aggtacagat ggattttctg caataacgga
    23461 cggcaggggt ttctggaaat gctggagggc aatggtcacc gcgctatccc cgtcataagg
    23521 gatatggcct gtcaacatct catagaaaat aatccccatg gcatagatat cactctgcac
    23581 agtcgccttc gaaccacgcg cctgctctgg tgacaagtaa tgaactgagc ccaacatcga
    23641 gttagtctgg gtcagacttg tctctgcaaa ggctacagca atcccaaagt ctgtgacctt
    23701 ggcagtccca tctggtgtca aaaggatatt ttgaggtttc aagtccctgt gaacaattcc
    23761 tcgagtatgg gccaagcgca tagccaagag aatttgtccc atgatacgga ctgcttcttc
    23821 attagaaaga ggataatgtt ccttgatata gcgtttgagg tccagtccag ccacatactc
    23881 catagctagg tactgttgac cgtcttcctc gccaatatct gttatccgaa cgatatgagg
    23941 atggtctaga tctgccatag ctctcgcttc acgctgaaaa cgagctacag ctatcgggtc
    24001 cgtctggtag ttggtcctca gaaccttcac tgccacttct tccccatcta agattaagtc
    24061 tttggctagg tagacatccg ccatgcctcc tcgaccaatc tgtttgacaa tccgatagcg
    24121 tccggcaaaa atcttgccga tttggatcat tctgcatcct cctcgttcat agaaacaagg
    24181 gcaaccgtaa tgttgtctaa acctcctgca ttgttagcaa aacgaacaag tgtctccgtt
    24241 ttatctgcta aaggaatatc actggttaca atatcacgaa tctcactgcc tgaaatcatg
    24301 ttggtcaagc cgtcactatt gagcaagaga tagtcacctg actcaaggat aactgtccca
    24361 aaatcaggct gaatttcatc tttttgccca atagactggg tgataatatt tttttgcgga
    24421 tgagcttctg cctcttctgg tgtcaattga ccagccttga gcaattcatt aaccaaggaa
    24481 tgatcgctcg tcaactgatg gtattcttct ccacgaatca agccgatacg cgaatcacca
    24541 atatgagcat agatagcctg attatcaata atagcaagga cttccaaagt agttcccatg
    24601 cctctgtaag cttcatcctg accaagctgg tgaatctttt gattttcaat ttctaggtaa
    24661 tgggcgaacc attcacgcac ttcattgact gtatcgatct gggtatcaac ccaagctaca
    24721 cccaggtctg tgaccgccat ttcactagcg atattccctg cacgatgacc tcccatccca
    24781 tcagctaaaa taatcatggt acgtccagct ctattgacat agtggttgac atagtcttgg
    24841 ttatttgttc gtttctgacc aacatctgtt aataatgaaa tttccatgtg tcagttcctt
    24901 cctaatccga tatcttgcga aattgactga tgaagaatcc atcacttcca tacaattcag
    24961 gtgtaatgag gatacagccg tctttcatga tatccttaca ttcatgttct agttttacct
    25021 gctcgaactc gggatgactc tctaaaaagg ccttaacgac ttgaaaattc tcctctgaga
    25081 cgatagtgca ggtgctataa gttattatac cacctttgcc tagtatttga caaacactac
    25141 ctaatatttc taactgaatt tcctgcaagg acgcgaaatc tgccgtttct ttattgtatt
    25201 tgatatctgg ttttcggcgc aaaagaccga ttcctgaaca aggagcatcc accaaaatct
    25261 tatcaaagga atcctggtca aaaaactcat gcacctttct ggcatccaat ttttgagttt
    25321 gaacccgatc ttcaactccc agacgttggg cattttcttg aattaaatcc aacttgtggt
    25381 cgtacaagtc cagagcagta acctgacctg tcgtaagata agaggctata tgggctgttt
    25441 tcccacctgg agccgcacag gcatcaagca ctcgctcatc accttgtaaa tcaagcgtcg
    25501 gagcaaccag ctgactggac tcgtcttgga tggtaatggc tccatccgca aacaagttat
    25561 gccctgcaaa atgcccttgc tccttaacca gaccagtggt tgctaaaagg gaattattcg
    25621 cctccaacaa ggcttggatt tcctcttttc gacttaggtc tgttacacga atactggctt
    25681 tgtttcgcac taacaagctt tcaaagatgg cttttgctct ctcctctccg tattcttcct
    25741 tgagtttggc aactagccaa actgggagag aataggcaat ggagtcacgc ttgttttttc
    25801 gcttgatgct agaaatatct ggccagcctt cacgcaagat acggcgaagg agggcattga
    25861 ccaatttttc actgcctttt ttacgaagtt tggccaattc cactgcttca ttgaccacag
    25921 catgatctgg aatcttgtcc aaatagcgga gttggtaggc actcatgaga agaaggacat
    25981 agagccagct gtctaactgg tctctgtctt cgataaagtg ggataggtac cattccagag
    26041 tcagtttacg ggctaccgtt ccatagacca gctcggtcac taagcccttg tctgctgcca
    26101 aaagttgact cccctttaga tgcttattta aggcgatatt tgagtatgct tggttcacaa
    26161 aaacatcctc tagcactgct agagctaaac ttctagccgt ttctacttta gtcaccaaat
    26221 cgttctccta cagtcaatgt acgtccaact ccgttgagga aggaagcaat gtccatctta
    26281 ggcttaccag ctggctgcac ttgtttgagg gatagagccc cttcagccgt tgcgacaatc
    26341 aattctttct tgccgataga gagaatctca cctggatttc cctgaccttc tactggtagg
    26401 gcttcataaa tcttaaagcg gtcgccctta aggaaagtat gggcaacagg ccaggggttc
    26461 attccacgaa tttggttaaa gagttgacga ttggttttgt tccagtccag tttttcttcc
    26521 tctggcttta tatttggaga gaaggtaacc tgactcgtat cctgcggttc aggtttgata
    26581 tcaccagcaa tataggcagg cagagtgtcc aaaagcaaat cacgaccaac tagcgccaat
    26641 ttttcaaaca aggtgccaac attgtcctca tctgtgatcg gaatgctgcg acgagaaatc
    26701 atatctcctg catccatttc cttaaccatt tccatgatgg tcacaccagc ttcctcatcc
    26761 ccttgaatca aggcataatg gataggcgca ccaccacggt gtctaggaag gagggaggca
    26821 tgaacgttga cagcaaagtc catgctatca aggagtttgc ttgggagaaa ctgcccaaaa
    26881 gcagcagtca caattccatc tgctcctagc ttcataagat cttccatctc tggacttcca
    26941 gataattttt caggttggta gatagatagt cctgcttcct tggcagcctg cttgactggg
    27001 gtttcttgga taactttttt acgaccaaca gcacggtctg gctgggtcac aacggctaga
    27061 atttcgtaac ggtcatctgt caaaagtcct tttaagactg ttgctgaaaa gtcgggggtc
    27121 cccataaaga ttagttttgt catatcttct ccttcttata aaaattgctg cggctcatgg
    27181 tcaatgctga gacggagctc actattttcc cgttcttgag tcaaggccaa gacctggttg
    27241 agggtcggcc ccagctcatc ttctaaacgg tatttaatta aaatctggta atgatagagg
    27301 ttgtgggtac gggcaatcgg ttttggcgtt ggccccagaa tgggactggt ctctgacaag
    27361 cctgaccgca aaatgttcat gacttcatag gcacgtttga aaacctcttc ttctttcttg
    27421 tgagaaaggg taataccaat cgtgaaatag taaggtggat agccgagttg tcgtctgatt
    27481 cccatttcat aggcataaaa gccttcgtaa tcttgatcct tggcaaatcg aatagcatag
    27541 tgctgcgaat tgtaggactg tatcaagact tgacctgctt tttcagcccg acctgctcga
    27601 cctgccacct gagtcaagag ctggaaggtt ctctcagaag aacggaaatc aggcagattc
    27661 aaggccgtat ccgcatttag aactccgact agggtaacat tgggaaaatc caaacccttt
    27721 gcaatcatct gagtaccaag taaaatatcc gcttcccctc gcccaaactg gtcaagcaag
    27781 gcttggtgac tgcctttctt tcgagtcgta tccacatcca tcctcaaaat gcgagcttgg
    27841 ggaaagagtt ctgctagctc atcataagcc ttctgagttc ccgtcccata gtaacgaata
    27901 ctgcggctct tacagttagg acagacctga ggaatatcct tcgagaaacc acaataatgg
    27961 cagttcatag tcttggtatc catatgcaag gtcagagaaa tatcgcagtt gggacaagta
    28021 tccaccgtcc cacactcccg acacatgaca aagctagaat aaccacggcg attgagcatg
    28081 agaaccacct gctctttttt aaccagacgg tcttggatag cctctagcaa aggaggcgta
    28141 aagtttgacg tctcattttg tccgatatag tctcgaaagt caatcacttg aacctcaggg
    28201 attgtagcca aaggattggc acgttgggtt agacgtaagt gttgatagac gcctttgcca
    28261 gcacgtgccc ggctctctaa gctcggcgtt gcagatccaa gtaccagagt tgcttgatta
    28321 tactgagccc gtaaaatagc tacctctctg gcatggtaac ggggattgct gtcctgctta
    28381 taagccgctt catgctcttc atcaataatc atgacaccca gatttttcag aggagcaaag
    28441 atagcagatc tggcaccaac aacaacttgg gcatcgccac gctccacctt gcgccattca
    28501 tcatactttt caccattgga taatcctgag tgaagaatgg ctaccttgtc cccaaaacgt
    28561 gctataaaac gctcggtcat ctgaggagtc aaggaaatct caggtaccag caaaatagct
    28621 gtcttgccct tatccagggc accttggata atctgcaagt aaacctcggt cttcccactt
    28681 cctgtaatcc cttgaagtag aaagggaggt tgagaactgc caatagaact cacaaccgca
    28741 tcacgcgcct gtctttgttc tggatttaac tccaaaggtc tacttgcttc aattccttca
    28801 aaataagcag ccgagcgttg aacttccttt tggactatgg taacagcacc ttgatccaca
    28861 aagaagttga cttgctctcg cgagtaggac tctaacaagc tagccaagga agcgctctct
    28921 ggatgagaca gcagataatc tctcagttcc aactttttct tggcacgtgt agaaatctca
    28981 acaccttcta attgagcatg gtcaacctca taccaagact gggtcttgac cttcttttga
    29041 tcgactgcct gatattccag aacaagcagg ccttttctag tcaaacgcat catttcagct
    29101 tgcttggcaa ggtctagtga agaaaaggct agcgaatctt ctgaaccaaa caggcgcact
    29161 cgttcttcct gactcaagcc ttccagagga tagagaatct tgtcatagct agaattcaga
    29221 aatcctggaa gcatggcctt gaggatagaa attttgtagg agaagacaga tttgcgtaac
    29281 tcctcagcca gccagagttg ttctggcgtg agaacaggag aaaaatccag cacctctgca
    29341 atatctttta aatcttgctc catctcttct ccatctgatt gggactccaa accaagaaca
    29401 atcccttgaa tcaggcgatt acccttacca aaaggcacat gaacccgcat cccaacttcc
    29461 agcattccct caaattcctc cggaatcctg taactatagg gctggtccgt ctgcatcaag
    29521 ggcacatcta cgataatctt agctagggcc atcttctcac ctcctccttg tcagtacatt
    29581 cttgcaatag aaaaaataag attgagtccc cccaacctta aattttttca ccatcttctt
    29641 tttctttagc aatttgctct ttgattttct tttcttcttc ttctttgcgg cgtttttctt
    29701 cttcgatacg gcgacgcact gcttcacgtt ttccttctgg atctgggtga attgtaacgt
    29761 ttcctgattc gatttcttct aaagcgcgaa gagttgattt ttcagacttg aaaccttgag
    29821 ttgctggggc acctgcttcc aattcgtggg cacgttttgc ttccaagatt acgagtgaat
    29881 attttgaagg aaccttgtcg agcaaggtat caatagaggg ttttaacatc atttgcttgt
    29941 acctattttc taaattttat cgggtagttg gagattttgg taacatctcc tgatagtgac
    30001 caatgacacg atccacacag aagtgttctg cttcaatcac acatttgaca cgttcagcag
    30061 ctagggacac ctgatcgttg acaatggcat aatcatactc acgcatgagg gcaatttctt
    30121 ccttggcctt ttcgattcgt tgggcaatca cttctgcact atctgttcca cgacctacca
    30181 agcgatcttg caattcatcc aaatctggtg gtgtcaggaa gataaagaca gcatctggaa
    30241 cctttttctt gacctgaaga gcaccctgaa cttcaatttc aaggaaaaca tcgattccct
    30301 tgtccaaggt ttcattgaca taggtcagag gagttccata gtagttaccg acatattctg
    30361 cgtattccaa catctgtcct tgacgaatca gctcttcaaa ttcttcacga gtacggaaga
    30421 aatagtcaac accgtccact tctccaggac gttgtgcgcg tgtcgtcatc gatacagagt
    30481 attgaaattg gttttcagaa ctctcaaaaa tctctcttct aaccgttcct tttccaaccc
    30541 ctgaaggacc agaaaaaacg attagtaagc ctcggtctgc cattgtgtct ccttttagtc
    30601 aatctgtgaa ataacatttc tctagaataa tggcaaaaag ccagattatc ctttacagtc
    30661 tttctatcta gtgtaacaaa aaagcagtaa tttttcaact gctctttctt atttatttag
    30721 cataatctac tgcacgaagc tcgcgaatca cggttacctt gatatttcct ggataatcga
    30781 gattgttttc aattttctta cgaactttgt gagccaagat tgtgactttg tcgtccttga
    30841 tttttcctgg attgaccatg atacgaattt cacgtcctgc ttgaagggca aagctagttt
    30901 gcactccttc aaagccgtta gcaatttctt ccaaatcatg gagacgcttg atgtagcttt
    30961 caagagactc actacgagca cctggacggg ctgcgctcaa ggcatctgct gcagcgacga
    31021 taactgctat cacgctctca gcttcaacat ctccgtggtg actagcaatc gtattcacca
    31081 caactggggg ttccttgtac ttacgggcca attccatacc gatttcaacg tggctacctt
    31141 caacctcatg gtcaatggct ttcccgatat cgtgaaggaa tccagcacga cgggcaagag
    31201 ccgcattttc accaagttcg ctcgccatga taccagccaa cttagcaacc tcaatcgaat
    31261 ggcgcaaaac attttgtcca tatgaagtac ggaactgcaa acgtcccata atcttcatca
    31321 agtctggatg aaggtttggc gcaccaattt cataggcagc agcctcaccg tattcacgaa
    31381 tcttattgtc aatctcttga cggtttttct caaccaactc ttcgatacga gctggatgta
    31441 tacgaccatc tttgagcaac atttccatag tcatacgggc aatctcacga cgaatcggat
    31501 caaatcctga caaggtcacc acttctggtg tatcgtcgat aatcacatcg acccctgtca
    31561 aactttcaaa ggtacgaatg ttacgacctt cacgaccaat aatgcgtccc ttcatagtat
    31621 cgtctggcag atgaactgtt gagtttgttg actccgctac atattcacca gcgatacgtt
    31681 gcatagcttg aaccaagatg tccttggcca ttttgtcaga acgttccttg acctcttgct
    31741 cagcttcgcg aatgcgactg gcaatctccc tggtcaagtt ttcctctgtc tgagccaaga
    31801 taatatctcg tgcttctgcc tgagacagag caccaatacg ctctagttct gcttcttttt
    31861 gtctttcgac ttcctctaat tgctcttcac gcgcatcaag gtttttcgct ctatcagaaa
    31921 tactttgttc tttttgttca agtgtttgtt ctttactcgt caaattgtcg tccttacggt
    31981 caaggctagt agctctctct gtcaaacgac tttcgatttg tttgagttct tgacgttctg
    32041 atttgaattc agcgtccact tcttcacggt attttctggc ttcttctttg gcctccaata
    32101 gtgcttcttt tttaagagac ttgctttcac gtttggcttc attaataagt aaatccgctt
    32161 cacgctcagc ttgtccacgt aaattagttg cttcttgttc agcatttaaa agcatcaact
    32221 ctgcagcttc ctgagatgat ttcatcttag ctgagatgct gacatatcca atgactaaac
    32281 caatgatgac ggcaaaaaca gcaatcgcaa gcgacatgat ctccatgttt ttacctcatt
    32341 ttattgttat tccgaatgac atacattctt ttacattcta ccataaaaaa gtgattttca
    32401 caaacctaaa atagaatatg ttttggggaa tttggaacac atttaccaaa ataaacttgt
    32461 tttttagaaa tagtagttta gtagagactt gagaaaaagc ctactttgca gtagacttcc
    32521 taatgattat gaaatacaag aagtttgttt ctaacaacag caagatttca ctcaggtatt
    32581 ctctgtaaat tagactagtg tcctgcgcga attttatcca ttcctcgtaa aaccttgtct
    32641 gataactcct tattttgggc gattctcagg gtttcctgaa tactgtccca ttcgctcttt
    32701 gaaagaacta caatgtcctc atctggattt ttattgacca ccgtcaaagg ctcaaattca
    32761 tcattta
//
LOCUS       DAVHIZ010000022        32731 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.022, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000022 DAVHIZ010000000
VERSION     DAVHIZ010000022.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 32731)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 32731)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..32731
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.022"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(137..1699)
                     /gene="guaA"
                     /locus_tag="VVO18_001034"
     CDS             complement(137..1699)
                     /gene="guaA"
                     /locus_tag="VVO18_001034"
                     /EC_number="6.3.5.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065723.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="HEU5586208.1"
                     /translation="MSNISTDLQDVEKIIVLDYGSQYNQLISRRIREIGVFSELKSHK
                     ISAAEVREVNPVGIILSGGPNSVYEDGSFDIDPEIFELGIPILGICYGMQLLTHKLGG
                     KVVPAGDAGNREYGQSTLTHTPSALFESTPDEQTVLMSHGDAVTEIPADFVRTGTSAD
                     CPYAAIENPDKHIYGIQFHPEVRHSVYGNDILRNFALNICKAKGDWSMDNFIDMQIKK
                     IRETVGDKRVLLGLSGGVDSSVVGVLLQKAIGDQLICIFVDHGLLRKGEADQVMDMLG
                     GKFGLNIVKADAAKRFLDKLAGVSDPEQKRKIIGNEFVYVFDDEASKLKDVKFLAQGT
                     LYTDVIESGTDTAQTIKSHHNVGGLPEDMQFELIEPLNTLYKDEVRALGTELGMPDHI
                     VWRQPFPGPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVR
                     SVGVMGDGRTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYD
                     ITSKPPATVEWE"
     gene            1841..2539
                     /locus_tag="VVO18_001035"
     CDS             1841..2539
                     /locus_tag="VVO18_001035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000936186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU5586209.1"
                     /translation="MLPAYMKIHDQIKKDIDEYRWAIGERLPSERDLAEQFAVSRMTL
                     RQAVSLLVEEGVLERRVGSGTFVSSTRVQEKMRGTTSFTEIVKSQGKVPSSQLISYKK
                     TIPNEQEVAKLGIFPTDNIIRMERVRYADQVPLVYEVASIPERFIKDFKKEEITSHFF
                     QTLQKHGYRIGKSQQTIYARLAKEKIAHYLEVEKGHAILGLTQVSYLEDGTAFEYVKS
                     QYVGERFEFYLENN"
     gene            complement(2582..3478)
                     /locus_tag="VVO18_001036"
     CDS             complement(2582..3478)
                     /locus_tag="VVO18_001036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000071673.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EamA family transporter"
                     /protein_id="HEU5586210.1"
                     /translation="MSNSLKGTLLTVVAGIAWGLSGTSGQYLMAHGISALVLTNLRLL
                     IAGGILMLLAYATAKDKILVFLKDRKSLLSLLIFALIGLFLNQFAYLSAIQETNAGTA
                     TVLQYVCPVGILIYSCIKDRVAPTLGEIVSIIFTIGGTFLIATHGQLDQLSMTPAGLF
                     WGLFSALTYALYIILPIALIKKWGSSLVIGVGMVIAGLVALPFTGVLQADIPTSLDFL
                     LAFAGIILIGTVFAYTAFLKGASLIGPVKSSLLASIEPISAVFFAFLIMNEQFYPIDF
                     LGMAMILFAVTLISLKDLFLEK"
     gene            complement(3487..4422)
                     /locus_tag="VVO18_001037"
     CDS             complement(3487..4422)
                     /locus_tag="VVO18_001037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000872223.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-lactamase family protein"
                     /protein_id="HEU5586211.1"
                     /translation="MKWTKIIKKIEEQIEAGIYPGASFAYFKDNQWTEFYLGQSDPEH
                     GLQTEAGLVYDLASVSKVVGVGTVCTFLWEIGQLDIDRLVIDFLPESDYPDITIRQLL
                     THATDLDPFIPNRDLLTAPELKEAMFHLNRRSQPAFLYSDVHFLLLGFILERIFNQDL
                     DVILKDQVWKPWGMTETKFGPVELAVPTVRGVEAGIVHDPKARLLGRHAGSAGLFSTI
                     KDLQIFLEHYLADDFARDLSQNFSPLDDKERSLAWNLEGDWLDHTGYTGTFIMWNRQK
                     QEATIFLSNRTYEKDERAQWILDRNQVMNLIRKEE"
     gene            complement(4419..5144)
                     /locus_tag="VVO18_001038"
     CDS             complement(4419..5144)
                     /locus_tag="VVO18_001038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001102210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CppA family protein"
                     /protein_id="HEU5586212.1"
                     /translation="MNVNQIVRIIPTLKANNRKLNETFYIETLGMKALLEESAFLSLG
                     DQTGLEKLVLEEAPSMRTRKVEGRKKLARLIVKVENPLEIEGILSKTDSIHRLYKGQN
                     GYAFEIFSPEDDLILIHAEDDRASLVEVGEKPEFQTDLASISLSKFEISMELHLPTDI
                     ESFLESSEIGASLDFIPAQGQDLTVDNTVTWDLSMLKFLVNELDIASLRQKFESTEYF
                     IPKSEKFFLGKDRNNVELWFEEV"
     gene            complement(5228..5863)
                     /locus_tag="VVO18_001039"
     CDS             complement(5228..5863)
                     /locus_tag="VVO18_001039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1-alkyl-2-acetylglycerophosphocholine esterase"
                     /protein_id="HEU5586213.1"
                     /translation="MAVQLLENWLLKEQEKIQTKYRHLNHISVVEPNILFIGDSIVEY
                     YPLQELFGTSKMIVNRGIRGYQTGLLLENLDAHLYGGAVDKIFLLIGTNDIGKDVPVN
                     ETLNNLEAIIQSVARDYPLTEIKLLSILPVNEGEEYQQAVYIRSNEKIQNWNQAYQEL
                     ASAYMQVEFVPVFDCLTDQAGQLKKEYTTDGLHLSIAGYQALSKALKDYLY"
     gene            complement(5865..6692)
                     /locus_tag="VVO18_001040"
     CDS             complement(5865..6692)
                     /locus_tag="VVO18_001040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5586214.1"
                     /translation="MMIKVIATDMDGTLLDARGQLDLPRLEKILDQLDQRGIRFVIAT
                     GNEIHRMRQLLSPLVDRVVLVVANGARIFENNELIQAQTWDDAIVNKALAHFKGRACQ
                     DQFVVTGMKGDFVKEGTIFTDLESFMTPEMIEKFYQRMQFVDELTSDLFGGVLKMSMV
                     VGEERLSSVLEEINALFDGRVRAVSSGYGCIDILQAGIHKAWGLEELLKRWDLKSQEI
                     MAFGDSENDVEMLEMAGIAYAMENADEKAKAVATALAPANSQGGVYQVLENWLEKGE"
     gene            complement(6714..7049)
                     /locus_tag="VVO18_001041"
     CDS             complement(6714..7049)
                     /locus_tag="VVO18_001041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="poly-gamma-glutamate biosynthesis protein"
                     /protein_id="HEU5586215.1"
                     /translation="MGNFISNQRIESMGDEENAKWTERGVLMDVTIKKKDGKTTIGTA
                     KAHPTWVNRTPKGTFSPEGYPLYHYQTYILEDFIEGGSHRDQLDEATKERIDTAYKEM
                     NEHVGLKWY"
     gene            complement(7050..7766)
                     /locus_tag="VVO18_001042"
     CDS             complement(7050..7766)
                     /locus_tag="VVO18_001042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001843873.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CapA family protein"
                     /protein_id="HEU5586216.1"
                     /translation="MAHGDLLYHDGLFFSAKKEDGTYDFHENFEYVTPWLKQADLAIG
                     DFEGTINKDHYLAGYLLFNAPVEVMDAIKEAGYHVLDLAHNHILDSQIEGVISTADII
                     EKAGITPIGVYTHEPRDQAPLVIKEVNGIKAALLAYSYGFNGIEQYISKEDYNRYLSD
                     LNEDKMKAEIERAEKEADITIIMLQMGVEYQLEPTEEQKALYHKMIDWGADIIFGGHP
                     HVVEPSETVEKDGDKKLIIY"
     gene            8279..8890
                     /locus_tag="VVO18_001043"
     CDS             8279..8890
                     /locus_tag="VVO18_001043"
                     /EC_number="3.5.1.88"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015058782.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide deformylase"
                     /protein_id="HEU5586217.1"
                     /translation="MSAIERITKAAHLIDMNDIIREGNPTLRAIAEEVTFPLSDQEII
                     LGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEA
                     YDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHR
                     IKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE"
     gene            8935..9663
                     /gene="rlmB"
                     /locus_tag="VVO18_001044"
     CDS             8935..9663
                     /gene="rlmB"
                     /locus_tag="VVO18_001044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151108.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA
                     (guanosine(2251)-2'-O)-methyltransferase RlmB"
                     /protein_id="HEU5586218.1"
                     /translation="MKTNDIVYGVHAVTEALLANTGNKLYLQEDLRGKNVEKVKELAT
                     EKKVSISWTSKKSLSEITEGAVHQGFVLRVSEFAYSELDYILAKTRQEENPLLLILDG
                     LTDPHNLGSILRTADATNVSGVIIPKHRAVGVTPVVAKTATGAIEHVPIARVTNLSQT
                     LDKLKDEGFWTFGTDMNGTPCHKWNTKGKIALIIGNEGKGISSNIKKQVDEMITIPMN
                     GHVQSLNASVAAAILMYEVFRNRL"
     gene            complement(9701..10612)
                     /gene="trxB"
                     /locus_tag="VVO18_001045"
     CDS             complement(9701..10612)
                     /gene="trxB"
                     /locus_tag="VVO18_001045"
                     /EC_number="1.8.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847397.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="HEU5586219.1"
                     /translation="MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSD
                     IENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRT
                     VIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLT
                     RFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKT
                     GQVTEQVFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLK
                     DLRQVTTAVGDGAIAGQEAYKFITEHS"
     gene            complement(10678..10902)
                     /locus_tag="VVO18_001046"
     CDS             complement(10678..10902)
                     /locus_tag="VVO18_001046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4059 family protein"
                     /protein_id="HEU5586220.1"
                     /translation="MLLQLFSLYFESLILTTILVLIFLGIWIGLRAMSGVDKTARARQ
                     AHLYDMIMIGVLVVPVLSFAVMSLILVFKA"
     gene            complement(10980..11723)
                     /locus_tag="VVO18_001047"
     CDS             complement(10980..11723)
                     /locus_tag="VVO18_001047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397450.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5586221.1"
                     /translation="MIKISNLSKSFSGQTVLDHLNLDIQKGEVVALIGSSGAGKSTFL
                     RSLNYLETPDSGSIQIDGFSVDFSKITQEEILALRRKLSMVFQQFNLFERRTALDNVK
                     EGLVVVKKLSDQEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDV
                     LLLDEPTSALDPELVGEVEKSIADAAKSGQTMILVSHDMSFVAQVADKILFLDKGKII
                     ESGTPDEIIHTPKEERTKEFFASYKRTYI"
     gene            complement(11723..12523)
                     /locus_tag="VVO18_001048"
     CDS             complement(11723..12523)
                     /locus_tag="VVO18_001048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001103446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5586222.1"
                     /translation="MNVTTILASDWYQNLMQLIPDGKLFSLRSVFDGIPRIVQQLPTT
                     IMLTIGGALFGLVLALLFAIVKINRVKILYPLQAFFVSFLKGTPILVQLMLTYYGIPL
                     ALKALNQQWGTGLNINAIPAAAFAIVAFAFNEAAYASETIRAAILSVNPGEIEAARSL
                     GMTRAQVYRRVIIPNAAVVATPTLINSLIGLTKGTSLAFSAGVVEVFAQAQILGGADY
                     RYFERFISVALVYWVVNIGIESLGRFIERKMAISAPDTVQTDVKGDLR"
     gene            complement(12681..13037)
                     /locus_tag="VVO18_001049"
     CDS             complement(12681..13037)
                     /locus_tag="VVO18_001049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arsenate reductase family protein"
                     /protein_id="HEU5586223.1"
                     /translation="MLEFIEYPKCSTCKKAKQELNQLGVDYKAVHIVEETPSQEVILN
                     WLETSGFELKQFFNTSGIKYRELGLKDKVGSLSNQEAAELLASDGMLLKRPILVENGT
                     VKQIGYRKSYEELGLK"
     gene            complement(13031..13561)
                     /locus_tag="VVO18_001050"
     CDS             complement(13031..13561)
                     /locus_tag="VVO18_001050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398798.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="HEU5586224.1"
                     /translation="MQKKYVKILYSSPIGILSLVADDHYLYGIWVQEQKHFERGLGDE
                     TIEEVVSHPILDPVIACLDDYFKGKPQDLSNLLLAPIGTNFEKRVWDYLQGIPYGQTV
                     TYGQIAQDLQVASAQAIGGAVGRNPWSILVPCHRVLGAGKRLTGYAAGVEKKAWLLEH
                     EGVDFKDRNNRRRSTC"
     gene            complement(13561..14055)
                     /locus_tag="VVO18_001051"
     CDS             complement(13561..14055)
                     /locus_tag="VVO18_001051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586225.1"
                     /translation="MEIRLAFPNEVDAIMQVMEDAKKCLADAGSDQWQNGYPNADVII
                     DDIISGQAYVALEEGELLAYAAVTKSPEEAYEAIYEGNWQAGESEYLVFHRIAVAADV
                     QGKGVAQTFLEGLIEGFDYLDFRSDTHAENKVMQHIFEKLGFKQVGKVPVDGERLAYQ
                     KLKK"
     gene            14190..14636
                     /locus_tag="VVO18_001052"
     CDS             14190..14636
                     /locus_tag="VVO18_001052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000858725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1836 domain-containing protein"
                     /protein_id="HEU5586226.1"
                     /translation="MKTTFSYPKWAEIPNIDLYLDQVLLYVNQVCAPISPNKDKGLTA
                     SMVNNYVKNGYLTKPDKKKYQRQQIARLIAITTLKSVFSIQEIAQTLNTLQTQASSDQ
                     LYDAFVDYMNQGIDPANPIIQTSCQTVKLYHQTLDLIDHTQEEVIQ"
     gene            14633..15280
                     /locus_tag="VVO18_001053"
     CDS             14633..15280
                     /locus_tag="VVO18_001053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001097995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin III family protein"
                     /protein_id="HEU5586227.1"
                     /translation="MNTSLKLSKQLSFGEEIANSVTHAVGAVIMLILLPISSIYSYEA
                     HGFLSSIGVSIFVISLFLMFLSSTIYHSMAYGSTHKYVLRIIDHSMIYVAIAGSYTPV
                     VLTLMNNWFGYLIIVIQWGTTIFGILYKIFAKKVNEKFSLALYLIMGWLVLAIIPAII
                     NQTTPVFWSLMVTGGLCYTVGAGFYAKKKPYFHMIWHLFILAASVLQYIAIVYYM"
     gene            complement(15301..15882)
                     /gene="pdxT"
                     /locus_tag="VVO18_001054"
     CDS             complement(15301..15882)
                     /gene="pdxT"
                     /locus_tag="VVO18_001054"
                     /EC_number="3.5.1.2"
                     /EC_number="4.3.3.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000689933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase glutaminase
                     subunit PdxT"
                     /protein_id="HEU5586228.1"
                     /translation="MKIGILALQGAFAEHAKVLDQLGVESVELRNLDDFQQDQSDLSG
                     LILPGGESTTMGKLLRDQNMLLPIREAILSGLPVFGTCAGLILLAKEITSQKESHLGT
                     MDMVVERNAYGRQLGSFYTEAECKGVGKIPMTFIRGPIISSVGEGVEILATVNNQIVA
                     AQEKNMLVSSFHPELTDDVRLHQYFINMCKEKS"
     gene            complement(15883..16758)
                     /gene="pdxS"
                     /locus_tag="VVO18_001055"
     CDS             complement(15883..16758)
                     /gene="pdxS"
                     /locus_tag="VVO18_001055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012054698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal 5'-phosphate synthase lyase subunit
                     PdxS"
                     /protein_id="HEU5586229.1"
                     /translation="MTENRYELNKNLAQMLKGGVIMDVQNPEQARIAEAAGAAAVMAL
                     ERIPADIRAAGGVSRMSDPKMIKEIQEAVSIPVMAKVRIGHFVEAQILEAIEIDYIDE
                     SEVLSPADDRFHVDKKEFQVPFVCGAKDLGEALRRIAEGASMIRTKGEPGTGDIVQAV
                     RHMRMMNQEIRRIQNLREDELYVAAKDLQVPVELVQYVHEHGKLPVVNFAAGGVATPA
                     DAALMMQLGAEGVFVGSGIFKSGDPVKRASAIVKAVTNFRNPQILAQISEDLGEAMVG
                     INENEIQILMAERGK"
     gene            complement(16910..18289)
                     /locus_tag="VVO18_001056"
     CDS             complement(16910..18289)
                     /locus_tag="VVO18_001056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="HEU5586230.1"
                     /translation="MSKIVVVGANHAGTACINTMLDNFGNENEIVVFDQNSNISFLGC
                     GMALWIGEQIDGAEGLFYSDKEKLEAKGAKVYMNSPVLSIDYDNKVVTAEVEGKEHKE
                     SYEKLIFATGSTPILPPIEGVEIVKGNREFKATLENVQFVKLYQNAEEVINKLSDKSQ
                     HLDRIAVVGGGYIGVELAEAFERLGKEVVLVDIVDTVLNGYYDKDFTQMMAKNLEDHN
                     IRLALGQTVKAIEGDGKVERLITDKESFDVDMVILAVGFRPNTALADGKIELFRNGAF
                     LVDKKQETSIPDVYAVGDCATVYDNARKDTSYIALASNAVRTGIVGAYNACGHELEGI
                     GVQGSNGISIYGLHMVSTGLTLEKAKAAGYNATETGFNDLQKPEFMKHDNHEVAIKIV
                     FDKDSREILGAQMVSHDIAISMGIHMFSLAIQEHVTIDKLALTDLFFLPHFNKPYNYI
                     TMAALTAEK"
     gene            18583..19506
                     /locus_tag="VVO18_001057"
     CDS             18583..19506
                     /locus_tag="VVO18_001057"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000175414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FAD:protein FMN transferase"
                     /protein_id="HEU5586231.1"
                     /translation="MTLRSHSERLMGTTITISLVDEQADIFLQKSFDLLKELEYRFNA
                     NSQESELMEINYQAGIAPVTVHPDLFELISLGLEHSLALSSHLNISIGPLIQTWRIGF
                     SDAKVAQPQEIESVLPLINPHGIELDSSTSTVFLKQKGMKIDLGCLAKGYSADKVAQF
                     LRKEGVTSALINLGGNILTIGKNQARGDNPWQIGIQDPANPRGNHLMTIPVVNKSVVT
                     SGIYERHLTVDGQDYHHIFDSQTGYPVETELASLTIISDKSVDGEIWTTRLFGERPAS
                     ILWQVESLEGIEVILIDKEGHLSCSSGIPTL"
     gene            19566..20171
                     /locus_tag="VVO18_001058"
     CDS             19566..20171
                     /locus_tag="VVO18_001058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU5586232.1"
                     /translation="MLKLIAIVGTNSKRSTNRQLLQYMQKHFADKAEIELVEIKAIPV
                     FNKPADKQVPAEILEIAAKIEETDGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNK
                     PIMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFNPSGDLVDLD
                     VIKKLDAIFDDFRIFVKITEKLRNAQELLRKDAEDFDWENL"
     gene            20190..21434
                     /locus_tag="VVO18_001059"
     CDS             20190..21434
                     /locus_tag="VVO18_001059"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000673688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="HEU5586233.1"
                     /translation="MKFVGLVGSNYDQSYNRKLLEFIRRYFKLKFELEVLEIDEVPMF
                     NQDEKWDESFQLRYLYNKITRADGVIIATPEHNHTISASLKSVLEWLSYEVHPFENKP
                     VMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDNNGNITNEG
                     TVKFLETCLDNFVKYVGVVSKLKKPKPIESEDLDCGKPIATTITEVDPDDPEWVEKVA
                     AITGAVSGDTYVKLDHGILTVNQIDMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMF
                     AKRVPPQSGSRMSTVHGSLPPARMKNVEWVIGTLRNGNQEYVRTIVPGSPAGVINTHN
                     YQAMYYPDGSYAGINEIVFNFQPWLDWYLKETGQRLVGGSGPFAPAAGSHGDADATSG
                     ASDSGDAGGHGGDADATAGASY"
     gene            complement(21551..21808)
                     /locus_tag="VVO18_001060"
     CDS             complement(21551..21808)
                     /locus_tag="VVO18_001060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002901318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF896 family protein"
                     /protein_id="HEU5586234.1"
                     /translation="MDPKKIARINELAKKKKTEGLTPEEKVEQAKLREEYIEGYRRAV
                     RHHIEGIKIVDEEGNDVTPEKLRQVQREKGLHGRSLDDPNS"
     gene            complement(21850..23886)
                     /locus_tag="VVO18_001061"
     CDS             complement(21850..23886)
                     /locus_tag="VVO18_001061"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit beta"
                     /protein_id="HEU5586235.1"
                     /translation="MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAI
                     QTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVE
                     DIEFREIKGEEYVYVTKEEVGQSVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVH
                     TLTVLLDEQEFDLDFLDIKGSRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCER
                     EQMIVDQIKEIEAKHGVHIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTS
                     MKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQ
                     KLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIY
                     KFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAV
                     LAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYA
                     LKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEV
                     SKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQ
                     LKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK"
     gene            complement(24146..25063)
                     /gene="glyQ"
                     /locus_tag="VVO18_001062"
     CDS             complement(24146..25063)
                     /gene="glyQ"
                     /locus_tag="VVO18_001062"
                     /EC_number="6.1.1.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018163989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycine--tRNA ligase subunit alpha"
                     /protein_id="HEU5586236.1"
                     /translation="MSKKLTFQEIILTLQQFWNDQGCMLMQAYDNEKGAGTMSPYTFL
                     RAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLESLEK
                     LGINPLEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATGPVTAE
                     VTYGLERLASYIQEVDSVYDIEWADGVKYGEIFIQPEYEHSKYSFEISDQEMLLENFD
                     KFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIARIRNLARVVA
                     KTFVAERKRLGYPLLDEETRVKLLAEDAE"
     gene            complement(25256..26017)
                     /locus_tag="VVO18_001063"
     CDS             complement(25256..26017)
                     /locus_tag="VVO18_001063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEU5586237.1"
                     /translation="MDNLYLVKDDSQLATFRDFVVRNTEKLKDYQSFLKNELAVCDLP
                     QAVIWSDFNAATQIIRESAVPAYTNNRRMVMAPDLAVWKELYLYQLMDYECSQQTQAI
                     ESHYHSLSENFLLQIVGHELAHWSEHFLDDFDGYDSYIWFEEGMVEYISRKYFLTEEE
                     FQAEKICNQSLVELFQKKYGWHSLNDFGFSTYDKNYASIFYEYWRSFLTVDKLVENLG
                     SVQAVLDSYHLWANTEKTFPLLDWFVQQKLIEKEI"
     gene            complement(26290..27132)
                     /locus_tag="VVO18_001064"
     CDS             complement(26290..27132)
                     /locus_tag="VVO18_001064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397460.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase"
                     /protein_id="HEU5586238.1"
                     /translation="MNTYQLNNGVEIPVLGFGTFKAKDGEEAYRAVLEALKAGYRHID
                     TAAIYQNEKSVGQAIKDSGVPREEMFVTTKLWNSQQTYEQTRQALEKSIEKLGLDYLD
                     LYLIHWPNPKPLRENDAWKTRNAEVWRAMEDLYQEGKIRAIGVSNFLPHHLDALLETA
                     TIVPAVNQVRLAPGVYQDQVVAYCREKGILLEAWGPFGQGELFDSKQVQEIAANHGKS
                     IAQIALAWSLAEGFLPLPKSVTTSRIQANLDCFGIELSHEERENLKTIAVQSGAPRVD
                     DVDF"
     gene            complement(27246..28637)
                     /locus_tag="VVO18_001065"
     CDS             complement(27246..28637)
                     /locus_tag="VVO18_001065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013193417.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="HEU5586239.1"
                     /translation="MNKSRLGRGRHGKTRHVLLALIGILAISICLLGGFIAFKIYQQK
                     SFEQKIESLKKEKDDQLSEGNQKEHFRQGQAEVIAYYPLQGEKVISSVRELINQDVKD
                     KLESKDNLVFYYTEQEESGLKGVVNRNVTKQIYDLVAFKVEETEKTSLGKVHLTEDGQ
                     PFTLDQLFSDASKAKEQLIKELTSFIEDKKIEQDQSEQIVKNFSDQDLSAWNFDYKDS
                     QIILYPSPVVENLEEIALPVSAFFDVIQSSYLLEKDAALYQSYFDKKYQKVVALTFDD
                     GPNPATTPQVLETLAKYDIKATFFVLGKNVSGNEDLVKRIKSEGHVVGNHSWSHPILS
                     QLSLDEAKKQITDTEDVLTKVLGSSSKLMRPPYGAITDDIRNSLDLSFIMWDVDSLDW
                     KSKNEASILTEIQHQVANGSIVLMHDIHSPTVNALPRVIEYLKNQGYTFVTIPEMLNT
                     RLKAHELYYSRDE"
     gene            complement(28872..29249)
                     /locus_tag="VVO18_001066"
     CDS             complement(28872..29249)
                     /locus_tag="VVO18_001066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001833802.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEU5586240.1"
                     /translation="MICQFIRDMLDLPAKNVTILEGSNIHVLPSMPYSAQDFYTSIDV
                     LAELDNGIQVIIEIQVHHQNFFINRLWAYLCSQVNQNLEKIRQREGDTHQSYKQIAPV
                     YAIAIVDSNYFSDDLAFHSFIVK"
     gene            29464..30441
                     /locus_tag="VVO18_001067"
     CDS             29464..30441
                     /locus_tag="VVO18_001067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="HEU5586241.1"
                     /translation="MLKLGVIGTGAISHHFIEAAHTSGEYQLVAIYSRKLETAATFAS
                     RYQNIQLFDQLEVFFKSSFDLVYIASPNSLHFAQAKAALSAGKHVILEKPAVTQPQEW
                     FDLIQTAEKNNCFIFEAARNYHEKAFTTIKNFLADKQVLGADFNYAKYSSKMPDLLAG
                     QTPNVFSDRFAGGALMDLGIYPLYAAVRLFEKANDATYHAQQLDNSIDLNGDGILFYP
                     DYQVHIKAGKNITSNLPCEIYTTDGTLTLNTIEHIRSAIFTDHQGNQVQLPIQQAPHT
                     MTEEVAAFAHMIQQPDLNLYQTWLYDAGSVHELLYTMRQTAGIRFEAEK"
     gene            30438..31520
                     /locus_tag="VVO18_001068"
     CDS             30438..31520
                     /locus_tag="VVO18_001068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase"
                     /protein_id="HEU5586242.1"
                     /translation="MKTKLPTEWQELSDQLGFQEFTPIQTQLFEPLLAGENLLGVSQT
                     GTGKTLAYLLPSLLRLQKKKAQQLLILAPNTELAGQIFDVCKTWAEAIGLTAQLFLSG
                     SSQKRQIERLKKGPEILIGTPGRIFELIKLKKIKMMNVETIILDEFDQLLDDSQIHFV
                     EKITHYAPRDHQLVYMSATTKFDQEKIVPNTRTIDLSDQKLDNIQHFYMQVDQRHRVD
                     ILRKLAHVEDFRGLVFFNSLSDLGNAEEKLQYRDILAVSLASDVNVKFRKVILEKFKD
                     NQLTLLLATDLLARGIDIDSLECVVNFDIPRDSETYTHRAGRTGRMGKEGYVITLVTH
                     TEEIKKLKKFASIREIVLKNQELYIK"
     gene            complement(31584..32614)
                     /locus_tag="VVO18_001069"
                     /pseudo
     CDS             complement(31584..32614)
                     /locus_tag="VVO18_001069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT         9662 a         7327 c         5887 g         9855 t
ORIGIN      
        1 ttttttgtcc aaatgtaaac cacttggaac tattattcaa tttattcttt ttagtaaatg
       61 ttcccgtttt aatcccagtt acagttttta atcctctgta accgttgatt ttacaaagct
      121 tttaattttt ttgcgattac tcccactcaa ctgttgcagg tggtttactt gtaatatcgt
      181 agacgatacg gttaacatga tccacttcat ttacgatacg tactgagatt ttttgaagta
      241 cttcccatgg aattttggca aaatcagcag tcataccatc gatagaagtg atagcacgga
      301 ttgcaatcgt gtagtcatac gtacgaccgt cacccataac accgactgaa cgaacgcctg
      361 tgttaacagt gaagtattgc caaatatcgc ggtcaagtcc agctttagcg atttcttcac
      421 gaagaatagc gtctgattca cgaacggttt caagtttctc ttcagtgatt tcacccatga
      481 cacggatagc aagtcctggt cctgggaatg gttggcgcca tacgatatgg tctggcatac
      541 caagctctgt accaagagca cgaacttcat ccttgtaaag agtattgagt ggttcaatca
      601 attcaaactg catatcttct ggaagaccac ccacgttgtg gtgtgacttg atagtttgag
      661 ctgtatccgt accagactcg ataacatctg tatataaagt accttgagca aggaatttca
      721 catctttgag cttgcttgct tcgtcatcga atacatagac aaactcgtta ccgatgattt
      781 tacgtttttg ttcagggtca gaaacgccag caagtttgtc aaggaaacgt ttagcagcgt
      841 ctgctttgac gatattcaaa ccaaacttac caccgagcat gtccataact tgatcagctt
      901 cgcctttacg aagaagaccg tggtctacga agatacagat caattgatcg ccaatcgctt
      961 tttggagaag aaccccaacg acagatgagt caacaccacc tgatagacca agaaggacac
     1021 gtttatcacc gacggtttca cgaatttttt tgatctgcat gtcaatgaaa ttatccattg
     1081 accagtcacc tttagcctta caaatgttaa gggcaaagtt acgaaggata tcatttccgt
     1141 atacagaatg acgaacttct gggtggaatt ggataccgta aatgtgttta tctgggtttt
     1201 cgatggctgc gtatgggcag tcagctgatg tacctgtacg aacaaagtca gcaggaatct
     1261 cagtaaccgc atcaccatgg ctcatcaaaa cagtctgttc atcaggtgtt gattcaaaaa
     1321 gcgctgatgg tgtgtgagtt agggttgatt gaccgtattc acgatttcca gcatcacctg
     1381 caggaacaac ttttcctcca agtttatggg tcaataactg cataccataa cagattccca
     1441 aaattggaat tccgagttcg aagatttctg ggtcaatatc aaatgaacca tcttcatata
     1501 cagaatttgg accacctgat agaataattc ctacaggatt gacttcacga acttcagcag
     1561 ctgaaatttt atggcttttt agttctgaaa aaacaccaat ctcacggata cggcgtgaaa
     1621 tcagctggtt gtactggcta ccatagtcca atacgatgat tttttctaca tcttgcaaat
     1681 cagttgaaat gttgctcatc tttttccttt ctcaaaagaa atatcttttc ccaatattct
     1741 atcacaaata agggcgaatt accaactaaa caaggcaaag tttgactttt tctagtttat
     1801 tggggtacaa tagagaaaag atagaaatga agtgaaaaat atgctacctg cttatatgaa
     1861 aatccatgat cagataaaaa aggatattga cgagtaccgt tgggctattg gtgagaggct
     1921 tccaagtgaa agagatttag ctgagcagtt tgcggtcagt cgtatgaccc tccgccaagc
     1981 cgtatctcta ttagtcgaag aaggcgtctt agagcgccgt gtaggaagcg gcacctttgt
     2041 ttccagtact cgagtacaag aaaagatgcg agggacaacc agttttactg aaattgtcaa
     2101 atcccaaggt aaagttccct ctagccagct catttcctac aaaaaaacca ttcccaatga
     2161 gcaagaagtt gccaagctag gaatttttcc aacggacaat attatccgaa tggagcgggt
     2221 ccgctatgcc gaccaagttc ccctagttta tgaagttgct tctattcctg aaagattcat
     2281 taaggacttt aaaaaagaag aaatcaccag tcatttcttc caaaccttgc aaaaacatgg
     2341 ttatcgtatc ggcaaatctc aacagaccat ctatgctcgc cttgctaaag aaaagattgc
     2401 ccactatttg gaagttgaaa aaggacatgc tattcttgga ttgacccagg tttcctacct
     2461 agaagatggt actgcttttg aatacgtaaa aagtcaatat gtaggcgaac gttttgaatt
     2521 ttatcttgaa aataattaga ttaccacgca aaaactctct gtcacggaca aagagtcttt
     2581 tttatttttc taagaataaa tctttcaaag aaatcaaagt tacagcaaac aatatcattg
     2641 ccataccaag aaaatcaatg ggataaaatt gttcattcat tattaagaag gcaaagaaaa
     2701 ccgccgatat tggctcaatt gaagccaaca agcttgactt gaccggtcct atcagactgg
     2761 ctcctttaag gaaagctgta taggcaaaga cagtcccgat aaggataatg cctgcaaacg
     2821 caaggagaaa atcaagacta gtcgggatat cggcctgtag aacccctgta aaaggaaggg
     2881 cgaccaaacc tgctatgacc attcccacac caatgaccaa gctgctcccc cactttttaa
     2941 tcaaggctat gggtaaaatg atatacagag cataagtcaa ggcagaaaag agaccccaga
     3001 acagaccagc aggtgtcatg gataactggt ccaactgccc atgtgttgcg atcaggaagg
     3061 ttcctccgat ggtgaatatg atggaaacta tctctcccag tgtcggtgcc accctatcct
     3121 tgatacagct ataaattaaa attccgacag gacaaacata ctgaagcacc gtcgctgttc
     3181 ccgcattggt ctcctgaata gcagacagat aggcgaattg gttgagaaaa agaccaatca
     3241 gagcaaaaat aagaagagac agcaaactct ttctatcctt taaaaagacc agtattttat
     3301 cctttgcagt agcataagcc aagagcatga gaattccacc agcgattaaa agacgcaagt
     3361 tggttaagac cagagccgaa attccgtgtg ccatcaggta ttggccactc gttcctgaca
     3421 acccccaagc aataccagcc acaactgtta gtaaagtccc ttttaaacta tttgacatgt
     3481 ctctccttac tcttctttgc gaatcaagtt catcacttga ttgcggtcta atatccattg
     3541 agctctctcg tccttttcat aggtacgatt cgataggaaa atagtggctt cttgcttctg
     3601 acgattccac atgataaagg tacctgtata gcccgtatgg tctagccaat ctccttccaa
     3661 attccatgct aaagaacgtt ccttgtcatc caaaggagaa aaattttgac ttaagtctct
     3721 tgcaaaatca tctgctaaat agtgttctaa aaagatttgt aaatccttta tagtcgaaaa
     3781 taaaccagcg ctcccagcat gtctacccag gagacgagcc ttgggatcat gcactatgcc
     3841 tgcctctaca cctctaactg ttggaacagc aagctcaact ggcccaaact tggtttccgt
     3901 cattccccaa ggtttccaga cttgatcctt taaaatcaca tccaaatctt gattaaaaat
     3961 tctttccaaa ataaagccca acagcaaaaa atggacatcc gaataaagaa aggctggctg
     4021 acttcgtctg ttgagatgaa acatcgcttc ctttaattca ggggctgtta aaagatcacg
     4081 attaggaata aaaggatcaa ggtctgttgc atgagtcaag agctggcgaa tagtaatgtc
     4141 tggataatca ctctcaggta aaaaatctat taccagtcta tcaatatcta attgacctat
     4201 ttcccacaag aaggtacaaa ctgtgccaac cccaacaacc ttgctgacac tagctaggtc
     4261 ataaactagt cctgcctcag tctgcaagcc atgctctggg tcactctggc ctaaatagaa
     4321 ctctgtccat tgattgtcct taaaatacgc aaaagaggct ccgggataaa ttcctgcctc
     4381 gatttgttct tctatttttt taataatctt ggtccacttc atacttcttc aaaccacaat
     4441 tcaacattat ttctatcttt accaaggaag aatttttcag acttaggaat aaaatattca
     4501 gtagactcaa acttctggcg aagacttgct atgtctaatt cattgaccaa gaacttgagc
     4561 atagataagt cccaggtaac cgtattgtcc acagtcaaat cctgcccctg agctggaata
     4621 aaatcaaggg atgccccaat ttcagatgat tccaagaaac tttcgatatc agttgggaga
     4681 tgtaattcca tagaaatctc aaatttactt aaagaaattg atgccaaatc tgtttgaaat
     4741 tcaggctttt ctcctacttc tactagactt gctctgtcat cttccgcatg aatcaaaatc
     4801 aaatcatctt ctggtgagaa aatttcaaaa gcgtagccat tttgaccttt atataatcga
     4861 tgaatcgaat ctgttttaga taagattcct tcaatttcta agggattttc caccttgaca
     4921 atcaatctag ctagtttttt tcttccctct accttacgag tacgcatact gggagcttct
     4981 tctaaaacca gcttttcaag acccgtttgg tcacctagtg acagaaaggc cgattcttct
     5041 aacaaggcct tcattccaag ggtttcaata taaaatgttt catttaattt tctattatta
     5101 gcttttaaag taggaataat ccgtacaatc tgatttacat tcataaattc ctccgtcact
     5161 ttttatttta aaggatttta gaatttttta caagatatta tgctcaaatt taacattatt
     5221 tagctattta gtaaagatag tctttcaagg cttttgacaa agcctgataa ccagcaatac
     5281 tgaggtgcag tccatcagtt gtatattctt ttttgagttg gcctgcttgg tctgtcaaac
     5341 aatcaaatac tggcacaaat tccacctgca tataggcaga tgcaagctct tgataggctt
     5401 gattccaatt ctgaattttt tcattcgagc ggatatagac tgcctgctgg tactcctctc
     5461 cctcattgac aggcaaaatg gaaagcaatt taatctctgt caatggataa tcgcgagcaa
     5521 cggattgaat gatagcttcg agattattga gagtctcatt cacaggaaca tcctttccga
     5581 tatcatttgt cccaatcaga agaaaaattt tatctactgc tccaccatat agatgagcat
     5641 caaggttctc tagtaacagt cctgtctgat agccacgaat tcctcgattg acaatcatct
     5701 ttgaagttcc aaatagctcc tgtagaggat aatactcgac aatggaatcc ccaataaaaa
     5761 gaatgtttgg ttctacaaca gaaatgtgat ttaggtgacg atatttggtt tgaatttttt
     5821 cttgttcctt tagaagccaa ttttctaata actgtactgc cacttcattc tcctttttct
     5881 aaccagtttt ccaagacttg ataaactcct ccttggctgt tggctggtgc tagagcagtc
     5941 gccacagctt tggctttctc atcagcattt tccatcgcat aggcaattcc agccatttca
     6001 agcatttcaa catcattttc actatcacca aaagccatga tttcttggga tttcaagtcc
     6061 cagcgcttga gtaattcctc caagccccat gctttatgaa tcccagcttg gaggatatca
     6121 atgcaaccat agccactgga tacagctcgg acacggccat caaagagagc attgatttct
     6181 tccaaaaccg aactcaaacg ttcctcacca acaaccatgc tcatcttgag cacaccacca
     6241 aagaggtcag atgttaattc atccacaaat tgcatccgtt ggtagaattt ttcaatcatt
     6301 tctggagtca taaaactttc aagatctgta aaaatcgtac cttccttgac aaaatcaccc
     6361 ttcatccccg ttacaacaaa ctggtcctga cacgctcgac ccttgaaatg agccaaagcc
     6421 ttgttgacaa tggcgtcatc ccatgtctga gcctgaatca attcattgtt ttcaaaaata
     6481 cgagcgccat tagcaacaac cagaaccact cgatccacca agggactcag tagttgtctc
     6541 atgcggtgaa tttcattgcc cgtcgcaatg acaaaacgaa tgcccctttg atccaactga
     6601 tctaaaatct tttccaatcg tgggagatca agctgacctc tagcatccag caaggtccca
     6661 tccatatctg tcgcaattac cttaatcatc atttactttc ctctggattc aagctaatac
     6721 cacttcaatc ccacatgttc attcatttct ttataggctg tatcaattcg ttccttagtc
     6781 gcttcatcta actggtcacg atgactgcca ccctctataa aatcttccaa aatataagtt
     6841 tggtaatgat acaagggata tccttctggt gaaaaggttc cctttggtgt tcgattgacc
     6901 caagtaggat gagctttagc tgttccgata gttgtttttc catccttctt cttgatggtg
     6961 acatccatga gaacaccacg ttcagtccac ttagcattct cttcatctcc catagattca
     7021 atccgttgat tggaaatgaa gttccccatt taatagataa tgagcttctt atctccatct
     7081 ttttcaaccg tttcagatgg ttcaacaacg tgaggatgcc ctccaaagat aatatccgct
     7141 ccccaatcga tcatcttgtg ataaagagct ttttgttctt cagttggttc caattgatac
     7201 tcaacaccca tctgaagcat gataatggtg atatctgctt ccttctctgc ccgttcaatt
     7261 tcagccttca tcttatcttc gtttaaatct gaaagataac gattatagtc ttccttagaa
     7321 atatactgct caattccatt gaaaccatag gaataggcta acaatgcagc cttgatacca
     7381 ttcacttcct taatgaccag cggagcctga tcacgtggtt cgtgcgtata aactccgatt
     7441 ggagtgattc cagctttctc aataatatcg gccgttgaaa taactccctc aatttgcgaa
     7501 tccaaaatat gattatgagc taaatccagc acatgataac ctgcctcctt aatagcatcc
     7561 ataacttcaa caggagcatt aaagagaaga taacccgcta aataatgatc cttattaatg
     7621 gttccttcaa aatcaccaat agctaaatct gcttgcttga gccaaggagt cacatactca
     7681 aaattttcat gaaagtcata ggtaccgtct tcttttttag ctgaaaagaa aagtccatcg
     7741 tggtagagca aatccccatg ggccataatt ctggcagttt tttcctcttc ctactcctga
     7801 gacttttgct tagtcccctc ttgagaaata gtatctcgtt tttgactagt caagggattc
     7861 cttggaagct ttcaaacaac aagatcaagc ccattgataa accaactgct agcaagagta
     7921 tcgccacaaa tcccttattg ctccacttgc gataactcct aaaaagttta ccaagccctt
     7981 cataaaacga aaagctaaac caccctgatt tcgattttgt cttctttgta tcttcgttct
     8041 ccctactttc ttatgcaagc cttttctttt tattatatca cagataagta tttctttcac
     8101 aattgaattg aacttcccat ctattttcta taaatcctaa atgccataat gctttcaatt
     8161 cttgtcattt tgtgatatca tgtagaggaa atgaactaat ccacagtggc ttattccaag
     8221 tataccactt gggctttggc agtaactaac tgcactaaac ataatataag gagagaaaat
     8281 gtctgcaata gaacgtatta caaaagctgc tcacttaatt gatatgaacg atattatccg
     8341 tgaagggaat cctactctac gcgcgattgc tgaggaagtc actttccccc tatctgacca
     8401 ggaaatcatc ctaggcgaaa agatgatgca attccttaaa cattcccaag atcctgtcat
     8461 ggctgaaaaa atgggactcc gcggtggtgt tggactggct gctccccagt tagatatctc
     8521 aaaacgcatt atcgctgttt tggtacctaa tattgttgaa gaaggcgaaa ctccacagga
     8581 agcctacgat ttggaagcca ttatgtacaa tccaaaaatc gtctctcact ctgttcaaga
     8641 tgctgctctt ggcgaaggag aaggttgcct gtctgttgac cgtaacgtgc ctggctatgt
     8701 tgttcgccat gcccgcgtta ctgttgacta ctttgacaaa gatggagaaa aacaccgtat
     8761 caaactcaaa ggctacaact ccattgttgt tcagcatgaa attgaccaca ttaacggtat
     8821 catgttttac gatcgcatca atgaaaaaga cccatttgca gttaaagatg gtttactgat
     8881 tcttgaataa agaaaatccc gttgcaagac ggggttttgt gttataatag aggcatgaaa
     8941 acaaatgata ttgtctatgg cgtccacgcc gttaccgaag ccctccttgc aaatacagga
     9001 aacaaactct acctccaaga agatctccga ggtaagaatg ttgagaaagt caaggaacta
     9061 gctacagaaa agaaggtgtc catttcttgg acatcaaaaa aatctctctc tgagattact
     9121 gaaggtgctg ttcatcaagg ttttgttcta cgagtgtctg aatttgccta tagcgagcta
     9181 gattacatcc ttgcaaaaac acgccaagaa gaaaatccac ttctattgat tctagatggt
     9241 ctaaccgatc cccataatct aggttctatc ttgcgaacag ccgatgcgac caatgtttca
     9301 ggtgtcatca ttcccaagca ccgtgctgtc ggagtaactc ctgtcgttgc caaaacagcc
     9361 acaggtgcta ttgaacacgt tccaattgcc cgagtgacca acctcagtca aaccttagat
     9421 aaacttaagg atgaaggttt ctggaccttt ggaacggata tgaacggtac tccttgccac
     9481 aagtggaata caaaagggaa aatcgccctc atcattggaa atgaaggaaa aggtatctct
     9541 agcaacatca aaaaacaagt cgatgagatg attaccattc cgatgaatgg acatgttcaa
     9601 agccttaatg ccagtgttgc tgcggccatt ctcatgtacg aagttttccg aaatagacta
     9661 taaaaagttt ccagtcatct gattggaaac ttttttataa ttaactatgt tctgtaatga
     9721 atttataggc ttcttgacca gcgatagctc catctccaac cgctgttgtt acttggcgaa
     9781 ggtctttcaa gcgaacatct ccaactgcaa agataccgtc gactgcagtt ttcatgtggt
     9841 tatctgtcac aatccatcct gcctgatctt ggatattcaa ttctttaaca aaatcgctaa
     9901 gagggtccaa accaacatag ataaagacac caccgaagac ttgttctgtc acttgacctg
     9961 ttttcacatt ttcaaatacg actgattcta ctcggttttc acccttgatt tcccttacta
    10021 cagaatccca gataaagctg attttttcat tcgcaaaggc gcgatcttgt aaaacctttt
    10081 gggcacgaag ttggtcacga cggtgaacaa tggtaacagt cttagcaaaa cgagtcaaga
    10141 agagggcttc ttcaacagct gaatctccac caccaactac caataaatct tggtcacgga
    10201 agaaagcacc atcacacaca gcacagtaag aaacaccacg actgttcagt tcttcttctc
    10261 caggtactcc caaaggacgg tgtttagaac cagttgctac gataactgta cgtgtttcat
    10321 atgtttggtc atcagtcatc actttcttaa aatcaccatg gtcttcgaca ttttcaacat
    10381 aaccataaat gtgctccaca ccaagatttt caagtggttc aaacatcttt tcagccaatt
    10441 caggtccact aatattagcg tatcctgggt aattttcgat atcagatgta ttattcatct
    10501 gaccacctgg cagaccacct tcaatcaaag ctacttttag attgcttcga gcagcataca
    10561 aggccgcagt catccctgca ggtccagcac cgataataat agtatcgtac atatagattc
    10621 cttctttctt gttgtaacta tctttattct aactctttct tgtcaatcac gcaaggatta
    10681 tgccttgaaa acaagaatta aactcataac cgcaaaggat aatactggga caaccaagac
    10741 tccaatcata atcatatcat agagatgggc ttgacgagcc ctggctgtct tatcaactcc
    10801 cgacatggct ctcagaccaa tccaaatccc taaaaaaatc agaacaagga tggtggtcaa
    10861 gatcaaactc tcgaaatata aagaaaatag ttgcagtagc atgatttctc tcatttctat
    10921 cttttttaaa gagtaaactc agctagtcca actaactgag ttttccttta tctattatat
    10981 caaatataag tccgtttgta actagcgaag aattcttttg tccgctcttc tttaggggtg
    11041 tggataatct catccggagt tccagactcg atgattttcc ccttatctaa gaagagaatt
    11101 ttatccgcaa cttgggctac aaaggacatg tcatgactga ccaaaatcat ggtctgacct
    11161 gacttagcag catctgcaat agacttttct acttcaccga ccaattctgg gtcaagggct
    11221 gaagttggtt cgtctaagag caaaacatct ggtttcatag caagcgcacg cgctagggca
    11281 acccgttgct tctgtccacc tgataaatgg cgaggataat ggttttcacg gtccgaaagc
    11341 ccaaccttag ccaactcttc cttggcaatc ttagtcgctt cttggtcaga taatttcttg
    11401 acaacaacca agccttcttt cacattatca agtgctgttc ggcgttcaaa caaattaaac
    11461 tgttggaaaa ccatagacaa cttacggcgt agggcaagga tttcttcttg agtgatttta
    11521 gaaaaatcaa ctgaaaaacc atcaatctga atagagccac tgtcaggtgt ttcaagataa
    11581 ttgagactgc gaagaaaggt tgattttcca gctcctgaag aaccaatcaa ggctacgact
    11641 tctccttttt gaatatccaa gttcagatga tccaagacag tctgtcctga aaaggatttg
    11701 cttaaattcg aaatcttaat cattaacgaa ggtctccttt cacatctgtt tgcactgtat
    11761 caggtgcaga aatagccatt tttctctcga tgaaacgacc gaggctttca attccgatat
    11821 tgactaccca ataaacaagg gcaacggaga tgaagcgttc aaaatagcga taatcagctc
    11881 cacctagaat ctgagcttgg gcaaagactt ccacaacacc cgcactaaaa gctagagatg
    11941 ttcccttggt caaaccgatg agggaattaa tcaaggttgg agtagctacc accgctgcat
    12001 taggaataat cactcgtcga taaacttgcg ctcgggtcat acccagactg cgtgccgcct
    12061 caatctcacc aggattaact gagagaatgg ctgcacgaat ggtttcacta gcataagctg
    12121 cctcattaaa ggcaaaggcg acaatcgcaa aagctgcagc tggaatcgca ttgatattga
    12181 gaccagttcc ccattgctga ttgagggctt tcaaagccaa aggaattccg tagtaggtca
    12241 acatgagttg caccaaaatc ggtgtccctt ttaagaaact aacaaagaag gcctgcaagg
    12301 gatataaaat cttgacacga ttgatcttca caatggcaaa aagaagcgcc aaaaccaagc
    12361 caaaaagggc accgccaatt gtcaacataa ttgttgttgg aagttgttgg acaattctag
    12421 ggattccatc aaagaccgaa cgtaggctaa acagcttgcc atccggaatc aattgcatca
    12481 agttttggta ccaatctgat gctaaaatcg ttgtaacatt cataaaaaca tcctcttctg
    12541 ataatgattc attctaccat gcttctgccg tcaatgaaat tatttgctac ggtcagatac
    12601 agactttgtc tacctactag tttatcatac tttgaaacag ggaagttata tattttatct
    12661 atcaaagaga tagataaaaa ctatttcagt cccagttctt cataagattt tcgataaccg
    12721 atttgcttaa cagttccatt ttctactaaa atgggccgtt ttaacaacat accgtcactt
    12781 gctagcaact cagccgcttc ttggtttgac aaacttccta ccttatcttt tagccctaat
    12841 tcacggtatt tgataccact ggtgttgaaa aattgcttca attcaaatcc tgaggtttct
    12901 agccaattca aaatgacttc ttggctaggt gtttcttcca cgatatggac ggctttatag
    12961 tccacaccta attgatttaa ttcttgtttt gcttttttac aagttgaaca tttggggtat
    13021 tcgataaatt ctaacatgtg cttctccttc tattgtttct atctttaaaa tctactcctt
    13081 catgctccaa gagccaagct ttcttttcca ctcctgcagc ataacctgtc agacgcttgc
    13141 ctgctcccaa cacacgatga caaggtacta ggatagacca aggattgcgt cccactgctc
    13201 caccaattgc ttgagcagaa gccacttgca ggtcttgagc aatttgtcca taggtcactg
    13261 tctgaccata aggaatgccc tgtaaatagt cccaaactct cttttcaaaa ttcgttccga
    13321 ttggcgccaa gagcaagttg gataaatcct gaggcttgcc tttaaagtaa tcatctaagc
    13381 aagcaataac tgggtctaaa ataggatgac taacaacttc ttctatcgtt tcatctccta
    13441 gtcccctctc aaaatgcttc tgctcctgaa cccaaattcc atacaaataa tggtcatcag
    13501 ctacaagtga tagaatacca attggtgagg agtagaggat ttttacatac ttcttttgca
    13561 ttatttcttt aatttttgat aggccaagcg ttcgccatct actggcacct taccaacttg
    13621 tttaaaacca agtttttcaa aaatatgttg cataaccttg ttttcagcat gcgtatctga
    13681 gcgaaaatca agataatcaa aaccttcaat caagccctct aagaaggttt gagcaactcc
    13741 ttttccctgc acatctgctg ccacagcaat acggtgaaag actagatact ctgactctcc
    13801 cgcttgccag tttccctcat aaatagcttc ataggcctcc tctggactct tggtcacagc
    13861 agcataggct agcagttctc cctcttccaa ggctacgtag gcttgccctg agatgatatc
    13921 atcgataata acatctgcat ttggatagcc attttgccac tggtcactac cagcatctgc
    13981 taaacatttt ttggcatcct ccatcacctg catgatggca tctacttcat ttggaaaagc
    14041 taaacgaatt tccatctttt ttcctcattt ctgactagtt tctcccatca tagcataatt
    14101 taagtatttc tacaagcagt taaaacttga ctttgtgttt ttgttatttt ataatctagt
    14161 tatcaaaact atataaaaag gagttgaaaa tgaaaactac cttttcctac ccaaaatggg
    14221 cagaaattcc aaacattgac ctctatctgg accaggtttt gctctatgtc aatcaggtct
    14281 gcgcccctat ctctcctaat aaagacaagg gcctaacagc atctatggtc aacaattatg
    14341 tgaaaaatgg ttacctgaca aagcctgaca aaaaaaaata ccaacgccaa cagattgccc
    14401 gtttgattgc tatcacaacc ctcaagtctg tattttctat tcaagaaata gcccagacac
    14461 ttaatactct acaaactcaa gcaagttcag accaactcta cgatgctttt gtggactaca
    14521 tgaaccaagg aattgaccca gctaacccta ttatccaaac cagctgccaa accgttaaac
    14581 tctatcatca aactctagac ttaatcgatc atactcaaga ggaggtaatc caatgaacac
    14641 tagtcttaaa ctcagcaaac aactcagttt tggagaggag attgctaata gcgtgaccca
    14701 tgctgtgggt gcagtcatca tgcttatctt gctgcctatt tcatccatct atagttatga
    14761 agcacacgga tttttatcct ctatcggcgt ttccattttc gtcatcagtc tctttctcat
    14821 gttcctatca tccaccattt atcactctat ggcctatggt tcgacccaca aatatgtttt
    14881 gcgaatcatt gaccattcta tgatttacgt tgccattgcc ggctcataca cgcccgttgt
    14941 cttgaccttg atgaataact ggtttggcta tctgattatt gtcatccaat ggggaacgac
    15001 catctttggt attctctata aaatctttgc taaaaaggtc aatgagaaat ttagccttgc
    15061 tctttacctg attatgggct ggttggttct ggctatcatt cctgccatta tcaatcaaac
    15121 gacacccgtt ttctggagtc tcatggtaac tggcggactc tgttatacag ttggagctgg
    15181 attttatgcc aagaaaaaac cttatttcca catgatttgg catctcttta tcctagctgc
    15241 gtccgtactc caatacatcg ctattgttta ttacatgtaa aaaagttgag aaattcaatc
    15301 tcaacttttt tctttacaca tattgataaa gtactggtgc aagcgcacat catcagtcaa
    15361 ttctggatga aaagaactta ccaacatatt tttttcttgg gctgcaacaa tttgattgtt
    15421 cactgttgct agaatttcta caccctcacc aacactactg ataatcggac cacggataaa
    15481 ggtcattgga atcttgccaa ctcccttaca ttctgcttcc gtgtagaaac ttcctaattg
    15541 gcgcccataa gcattacgct cgaccaccat atccatagtt cctagatgac tctctttctg
    15601 agaagtgatt tccttagcca gcaaaattaa gcccgcacag gtcccaaaca ctggtaagcc
    15661 agatagaatg gcttctcgga tgggaagtag catgttctgg tcacgtaaga gcttgcccat
    15721 ggttgtagac tcaccaccag gcaaaatcaa acccgacaag tcactctgat cttgctgaaa
    15781 atcatctaga tttctgagtt ctacactctc gacacctaat tgatctagca cttttgcatg
    15841 ttctgcaaag gccccttgca aggccaatat tccgattttc atctattttc ctcgttcagc
    15901 catgaggatt tggatttcat tttcattaat accaaccatg gcttctccta aatcttcaga
    15961 gatttgagct aggatttgag gattacggaa gttagtcaca gccttaacaa tggcactcgc
    16021 tcgtttaaca ggatctcctg acttgaaaat acctgaaccg acaaagaccc cctctgcccc
    16081 tagttgcatc attaacgcag catctgctgg cgttgcaaca cctccagcag cgaaatttac
    16141 aactggcaat tttccatgtt catgaacata ttggaccaat tctacaggga cttgcaaatc
    16201 cttggcagca acataaagct cgtcctcacg taagttttga atgcggcgaa tttcctgatt
    16261 catcatacgc atatgacgaa cagcttggac tatatcccct gtccctggtt ctcctttggt
    16321 acgaatcatg gaagcacctt cagcgatacg acgcaaggct tcacccaaat ccttagcacc
    16381 acagacaaaa ggaacttgga attctttctt gtccacatgg aaacggtcat cagctggaga
    16441 tagaacttca ctctcgtcga tataatcaat ttcaatagcc tctaaaatct gagcttcaac
    16501 aaaatgcccg attctgacct tagccattac tggaatacta accgcttctt ggatttcctt
    16561 aatcatcttt gggtcgctca tgcgggaaac tcctccagct gcacgaatat cagccggaat
    16621 tcgttccaag gccatcacag ctgccgcacc agcagcttct gcgatacgag cctgttcagg
    16681 attctgcaca tccataataa caccaccctt gagcatctgt gccaagtttt tatttagttc
    16741 ataacgattt tcagtcattt gttttatcct catcatttgt attggtagct accttttcat
    16801 tttaagtcag aacagaatga agcacaagat aaaaaaacta taattgtatg gggacaaatt
    16861 agctaaaaac tatctgacct taacttaagg ccagatagct cattcatttt tatttttcag
    16921 ccgtaagggc agccattgtg atgtagttgt atggtttgtt gaagtgtggc aagaagaaga
    16981 ggtctgtcaa tgccaattta tcaattgtca catgctcttg gatagcaagt gagaacatgt
    17041 ggattcccat gctaattgca atatcatgtg aaaccatttg ggcaccaaga atttcacggc
    17101 tatctttgtc aaagacaatc ttaattgcta cttcatggtt gtcatgtttc atgaattctg
    17161 gtttttgaag atcgttaaag cctgtttcag ttgcgttgta accagcagct ttcgcttttt
    17221 caagagtcaa accagttgaa accatgtgaa gaccgtagat tgagatacca tttgaacctt
    17281 gaacaccgat tccttccaat tcatgtccac aagcattgta ggcaccaacg ataccagtgc
    17341 gaacagcatt tgaagcaaga gcgatatagc ttgtatcttt acgagcattg tcataaacag
    17401 tcgcacagtc accaacagcg taaacgtctg ggatagatgt ttcttgtttc ttgtctacaa
    17461 ggaaggcacc gttgcggaag agttcgatct taccatctgc aagggctgtg tttggacgga
    17521 aaccaactgc aaggataacc atatccacgt caaagctttc tttgtcagta atcaagcgtt
    17581 caactttacc gtcaccttcg attgctttaa cagtttgacc tagagccaag cggatgttgt
    17641 gatcttccaa gttcttcgcc atcatttgtg tgaagtcttt gtcatagtaa ccgttcaaga
    17701 cagtatcaac gatatcaaca aggacaactt cttttccaag acgttcaaag gcttcagcaa
    17761 gttcaacacc gatgtaacca ccaccaacaa cggcgatacg gtcgaggtgt tggctcttgt
    17821 cagaaagttt attgataact tcttcagcat tttggtacaa tttcacgaat tgtacgtttt
    17881 caagagttgc tttaaattcg cggtttcctt taacaatttc aacaccttcg attggtggca
    17941 agattggtgt agaacctgta gcgaaaatca atttttcgta tgattctttg tgctcttttc
    18001 cttcaacttc cgctgtaact actttgttat catagtcgat tgaaagaaca ggtgagttca
    18061 tgtaaacttt agcaccttta gcttccaatt tttctttatc agaatagaac aagccttcag
    18121 caccgtcaat ttgttcacca atccaaagag ccattccaca tcctaggaaa gagatgttag
    18181 agttttggtc aaatacaaca atttcgttct catttccaaa attatccaac atggtattga
    18241 tacatgctgt accagcgtgg ttagcaccga ctacaacgat tttactcata aaaatttcct
    18301 gccttcattc taaatttacc ttactagtat accatttacc gttagcgttt acaagggggg
    18361 tactattatt tcagcatttt ttatcaaaaa taattcccca tttatcctgt tttcaagcct
    18421 catgaatttt atgagcatat ttcttgactt tttccaaatt ttgtttgtga aaattctaac
    18481 tttatggtat tataataaca tgaaaatgaa atgtaagggc ttcaatttag atgattattt
    18541 gatattacaa cttattttct ataagagaaa ggagttggta gcttgactct tcgttcacat
    18601 tctgaacggc taatggggac tactatcact atttcattag tggatgagca agccgatatc
    18661 tttctccaaa aatcctttga cttgctcaaa gaacttgaat accgcttcaa cgccaatagt
    18721 caagaatctg agttgatgga aatcaattat caagcaggaa tagcccccgt cacggttcat
    18781 ccagacctgt ttgagctgat ttcacttggg ttagagcata gcctagcgct ctctagccac
    18841 ctcaatatca gcattggtcc cttaattcaa acctggcgta tcggtttttc agatgccaag
    18901 gtcgcccagc ctcaagaaat tgaatcggtg ctgcctctaa tcaatcctca tggtatcgag
    18961 ttagattctt ctacttctac tgtgttttta aaacagaaag gaatgaagat cgatctaggt
    19021 tgtttagcca aaggatacag tgcggataag gttgcccaat ttcttaggaa agagggggtg
    19081 acttctgcct tgatcaatct gggagggaat atcctgacca ttggaaaaaa tcaggcaaga
    19141 ggggataacc catggcaaat cgggattcaa gacccagcca atcctagggg aaatcattta
    19201 atgaccatcc ctgttgtcaa taaatctgtc gtgacttcag gcatttatga acgtcacctg
    19261 accgtcgatg gacaagatta ccatcacatt tttgacagtc aaacaggata tcctgttgaa
    19321 acggaactag cgagtctaac aatcatctct gataaatcag tcgatggcga aatctggacg
    19381 actcgactct ttggagaaag acctgcttct atcctctggc aagtcgaaag tttggagggc
    19441 atcgaagtca tcctcatcga taaagaaggc cacctaagct gttcttcagg aattcctact
    19501 ctatagagac aactgtttca atggaatttt aaaattgtat tatgtaaaaa gagaaaggaa
    19561 atctcatgtt aaaacttatt gctattgttg gaacaaattc aaaacgttct acaaaccgtc
    19621 aattgctcca atacatgcaa aaacactttg ctgacaaagc tgaaattgag cttgttgaaa
    19681 tcaaggccat tcctgtcttc aacaaaccag ctgacaagca agtacctgct gaaatattgg
    19741 aaattgctgc taaaatcgaa gagacagatg gcgttattat cggtactcct gagtatgatc
    19801 actctattcc agctgttttg atgagcgctc ttgcttggtt gtcttatggt atttacccac
    19861 ttttgaacaa accaatcatg attacaggtg cttcttacgg tacgcttggt tcatctcgtg
    19921 cccaattgca acttcgtcaa atcttgaatg ctcctgaaat caaggcaaat gttcttccag
    19981 atgaattctt gctctcacac tctcttcaag catttaaccc aagtggcgac ttggttgacc
    20041 ttgatgttat caagaaattg gatgccatct ttgatgactt ccgtatcttc gtgaagatta
    20101 ctgagaaatt acgtaatgca caagaattac ttcgcaaaga tgctgaagac tttgactggg
    20161 aaaatttgta agataggaga ccaaaaagaa tgaaatttgt tggacttgtt ggatcaaact
    20221 acgatcaatc atataaccgt aagctcttgg aatttatccg tcgctacttc aaactcaaat
    20281 ttgaattaga agttcttgaa attgacgaag ttccaatgtt taaccaagat gaaaaatggg
    20341 atgaaagttt ccaattacgt tatttatata acaaaattac tcgtgcagat ggtgttatca
    20401 ttgctactcc tgagcataac cacactatct cagcttcact caaatctgta cttgaatggc
    20461 tttcatacga agttcatcca tttgaaaaca agcctgttat gattgtgggt gcatcatact
    20521 atgaccaagg aacatcacgt gctcaagttc accttcgtaa aatccttgat gctccaggtg
    20581 ttaatgccta cacgcttcca ggtaacgaat tccttcttgg taaagctaag gaagcttttg
    20641 ataacaacgg aaatatcacc aacgaaggca ctgttaaatt ccttgaaact tgcttagata
    20701 actttgttaa atacgtagga gtcgtttcga aattgaaaaa accaaaacca atcgaatcag
    20761 aagacttgga ttgtggaaaa ccaatcgcta caaccatcac agaagttgac cctgacgatc
    20821 cagaatgggt agaaaaagtt gcagcaatca ctggtgctgt ttctggtgat acctatgtca
    20881 aattggacca cggtatccta acagttaacc aaattgatat gttcttgaaa gctatgccat
    20941 ttgaattgac atacgctgac gacaacaacc aattcctcta ctacaacaac gctcaccaag
    21001 atccagacac tatgttcgct aaacgtgtac cacctcaatc aggtagccgt atgtcgactg
    21061 ttcatggttc tcttccacca gcacgtatga agaacgtaga gtgggttatc ggaacacttc
    21121 gcaacggaaa ccaagaatac gtccgtacga tcgttccagg ttctcctgca ggtgttatca
    21181 acactcacaa ctaccaagca atgtactatc ctgatggatc atacgctggt atcaatgaaa
    21241 tcgtctttaa cttccaacca tggcttgact ggtacctaaa agagactggt caacgtttgg
    21301 tgggtggtag cggaccattt gctcctgctg ccggaagtca tggagacgcc gatgctactt
    21361 ctggcgcttc tgattcaggg gatgctggag gccacggtgg tgacgcagac gctacagccg
    21421 gtgcaagtta ctaatgatag tttttaggaa ccattatggt tcctttttta gcgaaaaaag
    21481 actagcaaac acaaactgct agtctctttg ttatcgtttc atctatcttt gttaaaagaa
    21541 agaatacata ttatgaattt ggatcatcaa gactacggcc atgtaatcct ttttcacgtt
    21601 gtacttggcg tagtttttct ggtgtaacat cgtttccttc ttcgtccaca attttgattc
    21661 cttcaatgtg gtgacgaaca gcgcggcgat aaccttcgat gtactcctca cgtagtttgg
    21721 cttgttccac tttttcttct ggtgttaagc cttctgtttt tttcttttta gcaagctcat
    21781 tgatacgagc aatttttttc ggatccattt cttctccttt gtaataagat aaagtccgtt
    21841 tatcaaattt tatttagtgt taatttggtt aaaacaagca aacttagctg ctttcttggt
    21901 tagttgtgac aagattgcca aacgattttg acggacagcc tgatcttcag ccattaccat
    21961 agtattttca aagaaagcat caatgactgg gctaagcgca aagagttgtt tcaattgctg
    22021 acttgcaggt cctgataaaa cgagtgtttc tactgcttct gccaaagctt tttcttggtc
    22081 attctcaaat agtgctgaat caaccgtagc aaccccttct gccttctcag ccaggttaaa
    22141 ggcacgagaa agtgattcaa cagatggttt aaaatcttct tccttgctta cttctacgag
    22201 agcacttgct gcttccaaca tatctgccac aacaaagttt gaacctgcaa gaactgcttc
    22261 tttgatatct tttggagtag agcccatcat cttatcaaca cgagccttga taaagtccat
    22321 aacctctgct ttattttcat aagtcaaact gtcaaatttc aatgcataaa ggctatcaat
    22381 cagctcatcc atagcaatgt gccaaccaaa ggcatccaag atacgaacca caccttgagt
    22441 tgcacgacga agggcataag ggtcattaga acctgatgga atcaatccta ctgagaagaa
    22501 actcaaaatc gtatccaatt tgtctgcaat ggctagaact gcgccgacct tgctctctgg
    22561 aagttctcct tcagctgatg taggcatgta gtgttcacga atagcagctg ccaccgctgg
    22621 agtttcacca gcaagaaggg tgtatttttc acccataatt ccttggagtt cgtcaaattc
    22681 accaaccata cctgtcaaca agtcaaactt gtaaatggct gctgcacgag caaggtcaac
    22741 tgtttcatcc actgacaaac cagctttttc tgccaaaagt acagtgattt gacccgtacg
    22801 aatcatgtgt tcacgaaggg aaccaatctt ctcatggaag gtgacattgt ttaatttttc
    22861 aacaagatct gaaatcacca atttttggtc ttcacgccag aagaattctc cgtcttccaa
    22921 gcgggctacc aagacttttt catttccttt gatgacattt ttcaaacgct ctgcgtttcc
    22981 gttacgaaca gaaatgaagt ttggcaagag ttttccatct tgatcacgaa caacaaagta
    23041 acgctggtgt tccttcatag aagtcaccaa gacttcttct ggaacttcaa ggtatttagc
    23101 atcaaaactt cccatgaagg cagttgggta ttcaaccaaa ttcaagactt cattcagcaa
    23161 atccgcatca atttcgatat gtacaccatg ttttgcctca atttccttga tttggtcaac
    23221 aatcatttgc tcacgttcac atggatctgc gattacaaac tgcttacgaa ggtcttcttc
    23281 atagctcaat gctgactgaa ttttggtttc tttccccaag aaacgatggc cacggctcac
    23341 acgacttccc ttgatatcaa ggaaatccaa gtcaaactct tgctcatcca agagaacagt
    23401 taaagtgtga acagggcgga tgtattcaaa gctatttcca gcccagtgca tgctgacagg
    23461 gaaagtcaat gacttcaaga catctacaac accaggaaca atggcttcaa ctgattggcc
    23521 aacttcttcc ttagtgacat agacatattc ttcacccttg atttcacgga attcgatatc
    23581 ttcaacagtc aaacctttcc cacggacaaa tccttgagct gctttggtga agtttccatc
    23641 actatccaag gcaattttct ttgctggtcc cttgaaatct tctgtcaaat cagactgttt
    23701 gtctgataaa ccagtcacac gaacagccaa acgacgtggt gttgagaagg tttgaatggc
    23761 ttcaaaagac aggcggtttt ccttgaggaa ggctgccatt ttttcgccta gttgtttttc
    23821 acttggtgtg acaacatagg ctggtaattc ttcaagaccg agttctacta ataagttttt
    23881 tgtcatgttt tttcctttac attttcttca atcttttttg atatgcacct taggtactgg
    23941 ggacgtcgct aactaactct gtgagtctgt atggaaatcc aatgctaaat ttatcaagat
    24001 ttccaacaat ctcatcaaag tggatttagc tgactgattt ttgaacctaa ggtttcaaaa
    24061 atccccacat aacagtacgg cggtgcatat ccctctagca agtcttcgac ttgcctctaa
    24121 cgattttaga gtacagtatt actcactatt ctgcgtcttc tgctaaaagt ttaactcgtg
    24181 tttcttcatc caaaagtggg taacctaggc gtttgcgttc tgcaacaaag gttttggcta
    24241 caacacgggc caagttacgg atacgagcga tatagcctgc acgctctgtt acagatacgg
    24301 caccacgcgc gtcaagcaga ttaaaggtat gtgaacattt gagaacatag tcataggcag
    24361 ggtgtaccaa gccttcttct aatgcacgac cagcttcttt ttcaaactta tcaaagtttt
    24421 caagcaacat ttcttggtcc gaaatttcaa atgaatattt tgagtgctca tactcaggct
    24481 ggataaagat ttctccgtat tttacaccat cagcccactc gatatcatag acagagtcta
    24541 cttcttgaat gtaagaagcc aagcgctcca aaccataggt aacttccgca gtcacagggc
    24601 cagttgccaa tccaccgact tgttggaaat aagtgaactg agtgatttcc attccgtcaa
    24661 gccaaacttc ccaaccaaga ccagctgaac cagttgatgg gttttcccag ttgtcctcaa
    24721 caaaacgaat atcgtgctcc aaaggattga ttcccaattt ttccaaagat tcaaggtaaa
    24781 gttcttggat atttgatgga gaaggcttca tgaccacctg gaattggtgg tgttggtaga
    24841 gacggttagg gttttcccca taacgaccgt cagcaggacg acgtgatggc tctacataag
    24901 ctgcattcca tggctcaggt ccgatagcac gaaggaaagt gtaaggactc attgttcccg
    24961 cacctttttc attatcataa gcctgcataa gcatacaacc ttggtcattc caaaattgtt
    25021 gcaaagtaag gatgatttcc tggaaagtca atttcttaga cattgtttac tcctttttat
    25081 ataaattact tgcgacatga gtctgcctcg tcgatcatac gaggcaagac gagttagtac
    25141 tgcgtctagc tcaggcactc tagtgctgag cgtggggcag tccgactgta aggaggtttc
    25201 tgccactgac gcagtgaaat gtcaatttct tagacattgt ttactccttt agtttttata
    25261 tttctttttc aattaatttc tgctgaacaa accaatctaa caagggaaaa gttttttctg
    25321 tatttgccca taaatgataa gaatctaaga ccgcttgtac actacctaaa ttttctacca
    25381 acttatctac tgtcaaaaag ctgcgccagt attcataaaa aatacttgca tagttcttat
    25441 cataagtcga aaaaccaaaa tcattcaatg aatgccaacc atacttcttc tgaaaaagtt
    25501 ctacgagaga ttgattacaa attttttccg cttgaaattc ctcttctgtc aagaaatact
    25561 tgcgactaat atattcaacc atcccctctt cgaaccagat ataagagtca taaccatcaa
    25621 aatcatctaa aaaatgctcc gaccaatgag ctaactcatg tcctacaatc tgtaagagga
    25681 aattttcaga taaagaatga tagtgacttt ctattgcttg agtttgctga gaacactcgt
    25741 agtccatcaa ttgatacaaa tacaactctt tccaaacagc taaatcaggc gccataacca
    25801 ttcgtctatt atttgtatag gctggaacag cgctttccct aataatctgt gtagcagcat
    25861 taaaatctga ccaaataacg gcttgcggta aatcacagac tgcaagttca ttctttaaaa
    25921 aagattgata atctttcaac ttttcagtat ttcttactac aaaatcacga aatgtagcta
    25981 gttgactatc gtcttttaca agataaaggt tgtccacggc tctcctttct ttcacacaat
    26041 agactgaata agcaaaagaa ccgcgtccga caatcctagg ttgatttaac ctaggggcgt
    26101 cagaaacgcg gttccaccct aatttattac ttcattgttt ttgaaaatac tacagaaagc
    26161 gccagctcat tattttgccc tacttggctc ccactatccc aagctcgctt gaagaacgcc
    26221 ataagacttt ctttcctgct gactattata tcaaaaatta gaataatgta caattctttt
    26281 tatgattttc tagaaatcca catcatcaac tcgtggagca cccgattgaa cagcaatcgt
    26341 ttttaagttt tctctctcct catgactcag ttcaattcca aagcaatcaa gattagcttg
    26401 aatacgagag gttgtgacag attttggaag tggtaaaaat ccttctgcca agctccaggc
    26461 caaggctatc tgagcaatcg attttccgtg atttgctgcg atttcttgca cttgcttgct
    26521 atcaaatagt tctccctgac caaaaggccc ccaagcttcc aataaaattc ccttttcacg
    26581 acagtaagct acgacttgat cttgatacac acctggcgcc aagcgaactt gattgaccgc
    26641 aggaacgata gttgcagttt caagcaaggc atccaaatga tggggaagaa aattgctaac
    26701 gccgatagca cggattttcc cttcttgata gaggtcttcc atcgctctcc aaacttccgc
    26761 attgcgagtt ttccatgcgt cattttctct gagcggtttt gggttcggcc aatgaatcaa
    26821 atacaaatcc aaataatcca agcccagttt ttctatagat ttttccaaag cttgacgagt
    26881 ttgctcatag gtttgctgac tattccaaag cttggtagtt acgaacattt cttcacgtgg
    26941 aactccgcta tctttgattg cttgaccaac acttttttca ttctgataaa tcgccgccgt
    27001 atcaatatga cgataaccag ccttcaaggc ttctaacact gcacgatagg cttcttctcc
    27061 atccttagcc ttaaaagttc caaatcccaa tactggaatt tctactccat tatttaattg
    27121 ataggtattc atatgcttct ccttctattt tattcatcaa ttatagcata aaacattttt
    27181 taagtagtac tatcttctgt aaaaaataag tctgtcaaat atctaacaga cctatttttt
    27241 cttgcttatt catcacgact atagtacagc tcatgagctt ttaggcgagt attgagcatc
    27301 tctggtatgg tcacaaaggt ataaccttga tttttcaaat actcaatgac ccttggcaag
    27361 gcattgactg tcggactgtg aatatcatgc atcaaaacga tagagccgtt agctacttga
    27421 tgctgaattt ctgtcaaaat agatgcttca tttttactct tccagtccag actatccaca
    27481 tcccacatga taaagctcaa atccaagcta ttgcgaatat catctgtaat agcaccataa
    27541 ggtggacgca tgagtttaga actagaaccc agcactttag ttagcacatc ctcagtatca
    27601 gtaatctgct ttttagcttc atcaagagag agttgcgaga gaatcggatg gctccaacta
    27661 tggtttccaa caacatgacc ttcagatttt atcctcttca ccaagtcctc attcccagaa
    27721 acatttttcc caagcacaaa gaaagtcgct ttaatatcat atttagctag ggtctctaat
    27781 acctgcgggg tcgttgctgg atttggacca tcatcaaagg ttagagcgac aactttttga
    27841 tatttcttat caaagtaaga ttggtacaag gccgcatctt tttcgagtaa gtacgaagat
    27901 tggataacat caaagaaagc agatactggc aaggctatct cttctaaatt ttcaaccaca
    27961 ggacttggat aaaggataat ctgactatcc ttgtaatcaa aattccatgc agacaagtct
    28021 tggtcagaga agttttttac aatctgctca ctctggtctt gctctatttt tttatcctct
    28081 atgaaggagg tcaactcttt tatcagctgt tccttagcct tactagcatc tgaaaacagt
    28141 tggtcaagtg taaaaggttg gccatcttct gttaagtgaa cctttcctag actggtcttt
    28201 tcagtctctt caaccttaaa agcaactaaa tcatagattt gtttggtcac attacgatta
    28261 acgactccct ttaaacctga ctcttcttgc tctgtatagt agaaaacaag attgtcctta
    28321 ctttctagct tgtccttaac atcttgattt atcaactccc taacagagga aatcactttc
    28381 tccccttgga gaggataata ggcaatcact tcggcttgcc cctgacgaaa atgctccttc
    28441 tgatttccct cactcaattg atcatctttc tcttttttga gcgattcaat cttttgctca
    28501 aaactttttt gctggtagat cttaaaagca ataaatccgc ctaataggca aatagaaatt
    28561 gctaaaatac caatcaaagc caataataca tgtctcgttt tcccgtgtct gccacgtcct
    28621 agtctacttt tattcatatt tatatcataa caaatttgag caataatttc aatgatacaa
    28681 tttggcaatc cacaattcct ctagcaagcc aaagcatctt acatcaactc caacatccgt
    28741 atctgtagag attatgtagt tttctatcta tggaatttct agtagattga agctagaata
    28801 gtagacctat acttctaaaa cattgttaga aatcgatttg attgtcctga tcgatttgtc
    28861 ctgttctcat ttcattttac tataaaacta tgaaaagcta ggtcatctga gaagtaatta
    28921 ctatcgacaa ttgcgatagc gtatactggt gcgatttgtt tgtagctctg gtgggtatca
    28981 ccttcacgtt ggcgaatttt ttctaggttt tgattaacct gactgcacag ataagcccat
    29041 aggcgattga tgaaaaaatt ctgatgatga acctgaattt cgatgataac ttggattcca
    29101 ttatctaact ccgccaagac gtctatacta gtatagaaat cttgcgctga gtagggcatg
    29161 gaaggcaaga cgtgaatgtt acttccctcc aaaatcgtca cattttttgc tggcaagtcc
    29221 agcatatcgc ggataaattg acaaatcatt agttgggctg atacctggat gtctgagaat
    29281 cctccttttc ctccttctat tatagcacat ttttaaatct aggtttgcta gattctatgc
    29341 ttctatctat ttattcggaa aagaaagcta atagcttatt tgaaattttc tcctctctgt
    29401 tggatagtcc cgtctatcta tgttataatg aaagaaggat ttaaaatcgg aaaaggagta
    29461 tttatgctaa aattaggtgt catcggaact ggcgctatca gccatcattt catagaagca
    29521 gcccatacca gtggagaata ccaactggtc gcaatctatt ctagaaaact agaaactgca
    29581 gcaacctttg cttctcgcta tcagaatatc caactattcg atcaattaga agtcttcttc
    29641 aaatcttctt ttgatttagt ctatatcgcc agtccaaact ccttacattt tgctcaggca
    29701 aaagctgcct tgtctgctgg taaacatgtt attctcgaaa agccagctgt cactcaacca
    29761 caagaatggt ttgatttgat tcaaacagct gaaaaaaata actgttttat ctttgaagca
    29821 gctcgtaatt accacgagaa agcctttact actatcaaaa actttttagc agataagcaa
    29881 gtgttaggag cagatttcaa ctatgccaaa tactcttcca agatgcctga cttgttggct
    29941 ggacaaacac caaatgtctt ttcagaccgt tttgctggtg gagccctcat ggatttgggg
    30001 atttatcccc tctatgctgc tgttcgtctt tttgaaaaag ctaatgacgc gacttaccat
    30061 gctcaacagc ttgacaatag cattgaccta aatggagatg gtatcctctt ctacccagac
    30121 tatcaagttc acatcaaggc tggaaaaaac atcacttcca atcttccttg cgagatttat
    30181 acaacagatg gaaccttgac tctcaacacg attgagcata ttcgctcagc tatttttacc
    30241 gaccaccaag gaaatcaagt ccagcttcct atccaacagg ctcctcatac gatgactgag
    30301 gaagtcgctg catttgcaca catgatccag caaccagatc tgaatctcta ccaaacttgg
    30361 ctgtatgatg caggctctgt tcatgagcta ctatatacca tgcgccagac tgctggcatt
    30421 agatttgagg cagaaaaatg aaaaccaaac taccgactga atggcaagaa ctgagtgacc
    30481 aactcggttt ccaagaattc acccccattc aaactcaact atttgagccc cttcttgctg
    30541 gagaaaacct cctaggagtg agccaaaccg gaactggtaa gaccctagct tatctcctac
    30601 caagtcttct cagactacaa aagaaaaaag cccaacaact cttgattcta gcaccaaata
    30661 cggaacttgc tggacagatt tttgatgtat gtaaaacgtg ggcagaagct atcggattga
    30721 ctgctcaact cttcctttca ggttcaagtc agaaacgaca aattgaacgt cttaaaaagg
    30781 ggccagaaat tctgattgga actcctggcc gtatctttga actcattaaa cttaaaaaaa
    30841 tcaagatgat gaatgtggaa accatcatcc tggatgaatt tgaccaatta ctagatgatt
    30901 ctcagattca ctttgtagaa aaaatcactc actacgcacc tcgtgaccac caactggtct
    30961 acatgagtgc cacgaccaag tttgatcaag aaaagattgt accgaataca cgcactattg
    31021 atctctctga tcaaaaattg gacaatatcc agcatttcta catgcaggta gaccaacgtc
    31081 atcgagtgga tatactacga aaactggctc atgtagagga tttccgtggt ctagtcttct
    31141 tcaatagcct gtcagacctt gggaatgccg aggaaaaact acagtatcgt gatatattgg
    31201 ctgtttccct cgctagtgat gttaatgtta aatttagaaa agtcatctta gaaaagttta
    31261 aagataacca actaaccctg cttcttgcaa ctgacctttt ggctcgtgga attgatatcg
    31321 atagcctaga atgtgtcgta aactttgata ttcctagaga tagcgaaacc tacacacacc
    31381 gtgctggccg tactggccgt atgggcaagg aaggatatgt tattactctc gtcactcata
    31441 cagaagaaat caaaaaactt aaaaagtttg caagtatccg agaaattgtc ctaaaaaacc
    31501 aagaactcta tatcaaataa agccccattg ctctatacac atccagtgta tggagctttt
    31561 ttacaagcaa ttcaatttta tactcatctg ttttcaaaaa gcattctaat ccatctccga
    31621 ttaacgatgg actttatcac ctccttctcc agttcttgta taatatcttg aagttgattc
    31681 atgacatctt ccaaagttcg aaaggcttta ttcttaaatc cacgtttacg aatctctttc
    31741 cacacttgtt caacggggtt tatctctggt gtgtatggag gaataaatgc aaagccaata
    31801 ttagtcggaa tttttaaggt acttgattta tgccatatag cattgtccat aacgagtaaa
    31861 agataatcat ctggataagc ttgtgaaagc tcttctaaaa aggcgttcat ccactcagta
    31921 ttacatccac cagctcttaa gaaaaatgat tcgcctgtat gggcatcaac agctccataa
    31981 caatagcgaa attctcgtat atagtgacta tggacatgtg gacctactcc tattggagac
    32041 caacaagatc ccagtttact gattctaccg aaaccagcct catcttggta catcgagcga
    32101 accttatgaa aacgtctact ggttttaaag cgctttcttt tcttcttgaa ttgagatttt
    32161 atttttagac gcgacaatgg tttgagcgtc tgctttctta ggatgttctg gacgtggcat
    32221 aatatttcgc caaccatggc gcttcaacag ttgatagaag gcatcacgtg tgtaggaacg
    32281 atataagcct gaaataaggt attgtaacaa attctcctgc ctctgtagcc ttcaaatggc
    32341 gggcaagaaa ggctttctct tcctcaactg tcatatatgc atggttacga ccaccacgtg
    32401 tttcttgaag gagagagtcg agtccgaact cctcatattt ttttacattt cgccaaatcg
    32461 ttgtttgatt acagtctaaa agctctataa tctctttata agatttgccc atcagacgaa
    32521 atagaacgat ttgaaggcgt ttatgatatt tagctgtacg agagtctttt aaaagtgttt
    32581 tgatggtttg gatttcttct ttagttgatt tcatattact attgtataat gctttttgat
    32641 ttgagtctag tattatactc ttcgaaaatc tcttcaaacc gcgtcagctt cgccttgtcg
    32701 tatagatgtt actgacttcg tcagttctat c
//
LOCUS       DAVHIZ010000023        31744 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.023, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000023 DAVHIZ010000000
VERSION     DAVHIZ010000023.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 31744)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 31744)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..31744
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.023"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(122..895)
                     /locus_tag="VVO18_001070"
     CDS             complement(122..895)
                     /locus_tag="VVO18_001070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000731134.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ion transporter"
                     /protein_id="HEU5586243.1"
                     /translation="MKKKWFFADYYDTTIILLALISVILVLLGFAEMIDLDNPPYSII
                     DLVIWGVFVIDYSWRFFITKRKWRFILENVFDLLAILPLNAIFTVFRLGRIFRLVKLT
                     KLLKLTRLLRIIGLTGKLERKISRFLRTNGLIYILYVNIFIILVGSSILSVVEEKSFS
                     DSLWWTLVTVTTVGYGDIVPVSLLGKWLAVLLMLVGIGTIGMLTSALTNFFVKDNPDE
                     QIKLDKLQDELSSPRILLEKQSKKIEELHKMIQDLIEKT"
     gene            complement(942..1196)
                     /locus_tag="VVO18_001071"
     CDS             complement(942..1196)
                     /locus_tag="VVO18_001071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="HEU5586244.1"
                     /translation="MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKAL
                     VGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHRRDIY"
     gene            complement(1198..1440)
                     /locus_tag="VVO18_001072"
     CDS             complement(1198..1440)
                     /locus_tag="VVO18_001072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001853822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="HEU5586245.1"
                     /translation="MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYD
                     ARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE"
     gene            complement(1531..2340)
                     /locus_tag="VVO18_001073"
     CDS             complement(1531..2340)
                     /locus_tag="VVO18_001073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861619.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEU5586246.1"
                     /translation="MSEIGFKYSILASGSSGNSFYLETSKKKLLVDAGLSGKKITSLL
                     AEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMDLYANEKTWQAMENSKYLGKVDS
                     SQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
                     IVENADGYLIEANHDVEILRSGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKK
                     IYLGHLSKENNIKELAHMTMVNQLAQADLGVGVDFKVYDTSPDTATPLTEI"
     gene            complement(2342..3691)
                     /gene="vicK"
                     /locus_tag="VVO18_001074"
     CDS             complement(2342..3691)
                     /gene="vicK"
                     /locus_tag="VVO18_001074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886221.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall metabolism sensor histidine kinase
                     VicK"
                     /protein_id="HEU5586247.1"
                     /translation="MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQI
                     NQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFY
                     MTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
                     LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSH
                     ELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATS
                     HLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDN
                     ILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSR
                     AQGGTGLGLFIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED"
     gene            complement(3684..4388)
                     /locus_tag="VVO18_001075"
     CDS             complement(3684..4388)
                     /locus_tag="VVO18_001075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000722069.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586248.1"
                     /translation="MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAE
                     QPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSAKDSEFDKVIGLELGADDYVTKP
                     FSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
                     HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPE
                     YILTRRGVGYYMRNNA"
     gene            complement(4443..5618)
                     /gene="mutY"
                     /locus_tag="VVO18_001076"
     CDS             complement(4443..5618)
                     /gene="mutY"
                     /locus_tag="VVO18_001076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000886125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="HEU5586249.1"
                     /translation="MLDLKEYGIVMWPEEKVISFREKLLAWYDENKRDLPWRRSKNPY
                     HIWVSEIMLQQTRVDTVIPYYERFLDWFPTVESLATAPEESLLKAWEGLGYYSRVRNM
                     QAAAQQIMTDFGGQFPNTYEGISSLKGIGPYTAGAISSIAFNLPEPAVDGNVMRVLAR
                     LFEVNHDIGIPSNRKIFQAMMEILINPDRPGDFNQALMDLGSDIESPVNPRPEESPVK
                     DFSAAYQNGTMDRYPIKSPKKKPVPIYLKALVVKNSQGQFLLEKNESEKLLAGFWHFP
                     FIEVDNFSQEEQFDLFHQVAEESVNSGPSPEESFQQDYDLDVDWLDVCFDTVQHVFSH
                     RKWHVQIVAGQVSDFHDFSDREVRWLSPEEFKNYPLAKPQQKIWQAYAQANLDSSQD"
     gene            complement(5947..7617)
                     /locus_tag="VVO18_001077"
     CDS             complement(5947..7617)
                     /locus_tag="VVO18_001077"
                     /EC_number="6.3.4.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate--tetrahydrofolate ligase"
                     /protein_id="HEU5586250.1"
                     /translation="MKTDIEIAQSIELKPIVDVVEKLGISYDDLELYGKYKAKLSFDK
                     IRAVESNPVGKLILVTAINPTPAGEGKSTLTIGLADALNKIGKKTMIAIREPSLGPVM
                     GIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRR
                     ILWKRVVDLNDRALRHVTVGLGGPLNGIPREDGFDITVASEIMAILCLATDIEDLKRR
                     LANIVIGYRYDRTPVSVGDLQVEGALALILKDAIKPNLVQTIYGTPAFVHGGPFANIA
                     HGCNSVLATTTALHLADYTVTEAGFGADLGAEKFLDIKTPNLPTSPDAVVIVATLRAL
                     KMNGGVAKDALTEENVEAVRAGFANLKRHVENIRKFGIPAVVAINEFVSDTEAEIAAL
                     KELCASIDVPVELASVWADGAEGGVALAETVVKTIAENPANYKRLYDNDLSVQEKIEK
                     IVTEIYRGSKVNFEKKAQTQIAQIVQNGWDKLPICMAKTQYSFSDNPNALGAPENFEI
                     TIRELVPKLGAGFIVALTGDVMTMPGLPKRPAALNMDVESDGTVLGLF"
     gene            7847..8536
                     /gene="coaB"
                     /locus_tag="VVO18_001078"
     CDS             7847..8536
                     /gene="coaB"
                     /locus_tag="VVO18_001078"
                     /EC_number="6.3.2.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000699493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenate--cysteine ligase"
                     /protein_id="HEU5586251.1"
                     /translation="MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLFAGHEVC
                     LITTKRALKPEPHPNLSIREITNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGL
                     EEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
                     VDVTEDHLVDIARKSLIKNQADLIIANDLTQISTDQHRAIFVEKNQLQTVQTKEEIAE
                     LLLEKIQAYHS"
     gene            8548..9099
                     /gene="coaC"
                     /locus_tag="VVO18_001079"
     CDS             8548..9099
                     /gene="coaC"
                     /locus_tag="VVO18_001079"
                     /EC_number="4.1.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopantothenoylcysteine decarboxylase"
                     /protein_id="HEU5586252.1"
                     /translation="MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQ
                     PLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNM
                     VTSTALALPSHIPKLITPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
                     RGALADLTIILERIKETIDEKTL"
     gene            9083..9646
                     /locus_tag="VVO18_001080"
     CDS             9083..9646
                     /locus_tag="VVO18_001080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000747407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU5586253.1"
                     /translation="MKKRSNIAPIAIFFATMLVIHFLSSLIFNLFPFPIKPTIVHIPV
                     IIASIIYGPRVGVTLGFLMGLLSLTVNTITILPTSYLFSPFVPNGNIYSAIIAIVPRI
                     LIGLTPYLVYKLMKNKTGLILAGALGSLTNTIFVLGGIFFLFGNVYNGNIQLLLATVI
                     STNSIAELVISAILTLAIVPRLQTLKK"
     gene            9942..10469
                     /locus_tag="VVO18_001081"
     CDS             9942..10469
                     /locus_tag="VVO18_001081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ECF transporter S component"
                     /protein_id="HEU5586254.1"
                     /translation="MNTRKKTQFMTMTALLTAIAILIPIVMPFKIVIPPASYTLGSHI
                     AIFIAMFLSPLMAVFVILASSFGFLMAGYPMVIVFRAFSHISFGALGALYLQKFPDTL
                     DKPKSSWVFNFVLAVVHALAEVLACVLFYATSGTNVENMFYVLFVLVGFGTIIHSMVD
                     YTLALAVYKVLRKRR"
     gene            10481..10996
                     /locus_tag="VVO18_001082"
     CDS             10481..10996
                     /locus_tag="VVO18_001082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522046.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription repressor NadR"
                     /protein_id="HEU5586255.1"
                     /translation="MTKDRKQALLQLLKEAPKALNGQSLAEHFHVTRQVIVQDIAILR
                     ADGAPILSTNRGYIYKQIDTNPYVHKLFKVKHEVEEIGQELLAIVDNGGHVQNTLIDH
                     PVYGEIETLLKLSCRRDVQHFLEQVEHSDFRPLSELTDGVHYHLVEAETQQDLHYIEE
                     ALDQLGYLVKD"
     gene            complement(10993..11460)
                     /locus_tag="VVO18_001083"
     CDS             complement(10993..11460)
                     /locus_tag="VVO18_001083"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEU5586256.1"
                     /translation="MSRSQLTILTNICLIEDLETQRVVMQYRSPDTNRWSGYAFPGGH
                     VENGESFAESVIREIYEETGLTIQNPQLVGIKNWPLDTGGRYIVVCYKATEFSGTLRS
                     SDEGEVSWIQKDQIPNLDLAYDMLPLMEMMEAPDKSEFFYPRRTEDDWEKEIF"
     gene            complement(11533..12021)
                     /locus_tag="VVO18_001084"
     CDS             complement(11533..12021)
                     /locus_tag="VVO18_001084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254187.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586257.1"
                     /translation="MVITVKQMETPEEIEGKSLVHWKAWRESYDDLLPAEFQETMTLE
                     RCRLFSQKYPENTLIAMDGLKVVGFISYGNFRDETIQAGEIIALYVLKDYYGKGIAQK
                     LMKAALTALDHFSEIFLWVLKDNKRAIAFYQKMGYTFDGQEKILELGKPIKEKRMVFY
                     SK"
     gene            complement(11987..12550)
                     /locus_tag="VVO18_001085"
     CDS             complement(11987..12550)
                     /locus_tag="VVO18_001085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586258.1"
                     /translation="MIYLRKLKKEDLMSLWEMAYSQLNPVWKQYDAPYYDDYQYFSNF
                     KEFELQKSESILSNSNRLGIFVDDKLVGTVSRYWVCKQTRWMELGIGIYDKKFWNTGI
                     GKVAMLQWIDRTFQDYLELEHLGLTTWSGNFGMMKLAEKLRMKKEAHIPKVRYYQGVY
                     YDSIKYGILREEWEEANGHHCQTDGNS"
     gene            complement(12560..14548)
                     /gene="uvrB"
                     /locus_tag="VVO18_001086"
     CDS             complement(12560..14548)
                     /gene="uvrB"
                     /locus_tag="VVO18_001086"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excinuclease ABC subunit B"
                     /protein_id="HEU5586259.1"
                     /translation="MINRITDNKFKLVSKYQPSGDQPQAIEQLVDNIEGGEKAQILMG
                     ATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYGEFKEFFPENAVEYFVSYYDYYQ
                     PEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYA
                     DSVVSLRPGLEISRDKLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFR
                     VEFFGDEIDRIREVEALTGQVLGEVDHLAIFPATHFVTNDDHMEVAIAKIQAELEEQL
                     AVFEKEGKLLEAQRLKQRTEYDIEMLREMGYTNGVENYSRHMDGRSEGEPPYTLLDFF
                     PDDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVH
                     QIVYVSATPGDYENEQTETVIEQIIRPTGLLDPEVEVRPTMGQIDDLLGEINARVEKN
                     ERTFITTLTKKMAEDLTDYFKEMGIKVKYMHSDIKTLERTEIIRDLRLGVFDVLVGIN
                     LLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVIMYADTVTQSMQ
                     RAIDETARRRKIQMAYNEEHGIVPQTIKKEIRDLIAVTKAVSKEEDKEVDINSLNKQE
                     RKELVKKLEKQMQEAVEVLDFELAAQIRDMMLEVKALD"
     gene            complement(14625..15578)
                     /locus_tag="VVO18_001087"
     CDS             complement(14625..15578)
                     /locus_tag="VVO18_001087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000792120.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5586260.1"
                     /translation="MKNKRIFKDFQASKMSLNIYTSPLLAFVFVFIGEFVAFTLYGIG
                     LLALIGLARNFGEAGQNLASYLQTLHQSLTDKTSDFRLILGLLAFGFILNTVFRWTRK
                     VEKRPIRTLGFYRENFLSNLLKGFSLGLALFLLTLLGLVALGQYRLDSIHLDTYSLAF
                     TLFTIPFWILQGTAEELVTRAWLIPQLAKRTNLKVAIIISSSLFTLLHLGNPGITFLS
                     AIDLFLFGVAMSLYLLKTDTIWGIGGIHGAWNFAQGNLFGVLVSGQSSGTSIMKFTPQ
                     GNQDWLSGGSFGIEGSIVSSIILFLLILYLAYQLKKENERM"
     gene            15748..17913
                     /locus_tag="VVO18_001088"
     CDS             15748..17913
                     /locus_tag="VVO18_001088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEU5586261.1"
                     /translation="MKKKFLAFLLILFPIFSLGIAKAETIKIVSDTAYAPFEFKDSDQ
                     TYKGIDVDIINKVAEIKGWNIQMSYPGFDAAVNAVQAGQADAIMAGMTKTKEREKVFT
                     MSDTYYDTKVVIATTKSHKISKYDQLTGKTVGVKNGTAAQRFLETIKDKYGFTIKTFD
                     TGDLMNNSLSAGAIDAMMDDKPVIEYAINQGQDLHIEMDGEAVGSFAFGVKKGSKYEH
                     LVTEFNQALAEMKKDGSLDKIIKKWTASSSSAVPTTTTLAGLKAIPVKAKYIIASDSS
                     FAPFVFQNSSNQYTGIDMELIKAIAKDQGFEIEITNPGFDAAISAVQAGQADGIIAGM
                     SVTDARKATFDFSESYYTANTILGVKESSNIASYEDLKGKTVGVKNGTASQTFLTENQ
                     SKYGYKIKTFADGSSMYDSLNTGAIDAVMDDEPVLKYSISQGQKLKTPISGTPIGETA
                     FAVKKGANPELIEMFNNGLANLKANGEFQKILDKYLASESSTASTSTVDETTLWGLLQ
                     NNYKQLLSGLGITLALALISFAIAIVIGIIFGMFSVSPYKSLRVISEIFVDVIRGIPL
                     MILAAFIFWGIPNFIESITGQQSPINDFVAGTIALSLNAAAYIAEIVRGGIQAVPVGQ
                     MEASRSLGISYGKTMRKIILPQATKLMLPNFVNQFVIALKDTTIVSAIGLVELFQTGK
                     IIIARNYQSFKMYAILAIFYLVIITLLTRLAKRLEKRIR"
     gene            17913..18653
                     /locus_tag="VVO18_001089"
     CDS             17913..18653
                     /locus_tag="VVO18_001089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5586262.1"
                     /translation="MAKLKIDVNDLHKHYGKNEVLKGITTKFYEGDVVCIIGPSGSGK
                     STFLRSLNLLEEVTSGHITVNGYDLTEKTTNVDHVRENIGMVFQHFNLFPHMSVLDNI
                     TFAPIEHKLMTKEEAEELGMELLEKVGLADKANANPDSLSGGQKQRVAIARGLAMNPD
                     IMLFDEPTSALDPEMVGDVLNVMKELAEQGMTMIIVTHEMGFARQVANRVIFTADGEF
                     LEDGTPDQIFDNPQHPRLKEFLDKVLNV"
     gene            18802..20289
                     /locus_tag="VVO18_001090"
     CDS             18802..20289
                     /locus_tag="VVO18_001090"
                     /EC_number="1.1.1.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096131.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="HEU5586263.1"
                     /translation="MSSKVIVTIFGASGDLAKRKLYPSLFRLYKSGNLSKHFAVIGTA
                     RRPWSKEYFESVVVESILDLADSTEQAQEFASHFYYQSHDVNDSEHYIALRQLQAELN
                     EKYQAEHNKLFFLSMAPQFFGTIAKHLKSENIVDGKGFERLIVEKPFGTDYATASKLN
                     DELLATFDEEQIFRIDHYLGKEMIQSIFAVRFANLIFENVWNKDFIDNVQITFAERLG
                     VEERGGYYDQSGALRDMVQNHTLQLLSLLAMDKPASFTKDEIRAEKIKVFKNLYHPTD
                     EELKEHFIRGQYRSGKIDGMKYISYRSEPNVNPESTTETFTSGAFFVDSDRFRGVPFF
                     FRTGKRLTEKGTHVNIVFKQMDSIFGEPLAPNILTIYIQPTEGFSLSLNGKQVGEEFN
                     LAPNSLDYRTDATATGASPEPYEKLIYDVLNNNSTNFSHWDEVGASWKLIDRIEKLWA
                     ENGAPLHDYKAGSMGPQASFDLLEKFGAKWTWQPDIAYRQDGRFE"
     gene            complement(20333..21622)
                     /gene="ftsY"
                     /locus_tag="VVO18_001091"
     CDS             complement(20333..21622)
                     /gene="ftsY"
                     /locus_tag="VVO18_001091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522312.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle-docking protein
                     FtsY"
                     /protein_id="HEU5586264.1"
                     /translation="MGLFDRLFGKKEEPKIEEVVKEALENLDLSEDVDPTFTEADEVP
                     QEEAEVEIVEQAVFQEEEIQDTVEESQDSEPAVGVSQEEIEELPNSEELPEEEKLEHE
                     GTIEENNSEVLEPERPQTEETVQEKYDRSLKKTRTGFGARLNAFFANFRSVDEEFFEE
                     LEELLIMSDVGVQVASNLTEELRYEAKLENAKKPDALRRVIIEKLVELYEKDGSYDES
                     IHFQDNLTVMLFVGVNGVGKTTSIGKLAHRYKRTGKKVMLVAADTFRTGAVAQLAEWG
                     RRVDVPVVTGPEKADPASVVFDGMERAVAEGIDILMIDTAGRLQNKDNLMAELEKIGR
                     IIKRVVPEAPHETFLALDASTGQNALVQAKEFSKITPLTGIVLTKIDGTARGGVVLAI
                     REELNIPVKLIGFGEKIDDIGEFNSENFMKGLLEGLI"
     gene            complement(21626..22444)
                     /locus_tag="VVO18_001092"
     CDS             complement(21626..22444)
                     /locus_tag="VVO18_001092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465979.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5586265.1"
                     /translation="MADIKLIALDLDGTLLTTDKRLTDRTKETLKAARDRGIKVVLTT
                     GRPLKAMDFFLHELGTDGQEDEYTITFNGGLVQKNTGEILDKTVFSYDDVARLYEETE
                     KLSLPLDAISEGTVYQIQSDQESLYAKFNPALTFVPVDFEDLSNQMTYNKCVTAFAQE
                     PLDAAIQKISPELFDQYEIFKSREMLLEWSPKNVHKATGLAKLISHLGINQSQVMACG
                     DEANDLSMIEWAGLGVAMQNAVPEVKAAANVVTPMTNDEEAVAWAIEEYVLKEN"
     gene            complement(22444..23238)
                     /locus_tag="VVO18_001093"
     CDS             complement(22444..23238)
                     /locus_tag="VVO18_001093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000153012.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Cof-type HAD-IIB family hydrolase"
                     /protein_id="HEU5586266.1"
                     /translation="MTIKLVATDMDGTFLDGNGRFDMDRLKSLLASYKEKGIYFAVAS
                     GRGFLSLEKLFADVRDDIIFIAENGSLVEYQGQDLYEATMSRDFYLVTFEKLKTSPYV
                     DINKLLLTGNKGSYVLDTVDETYLKVSQHYNENIQKVASLEDITDDIFKFTTNFTEET
                     LEDGEAWVNENVPGVKAMTTGFESIDIVLDYVDKGVAIVELVKKLGITMDQVMAFGDN
                     LNDLHMMQVVGHPVAPENARPEILELAKTVIGHHKDQSVIAYMEGL"
     gene            complement(23235..26774)
                     /gene="smc"
                     /locus_tag="VVO18_001094"
     CDS             complement(23235..26774)
                     /gene="smc"
                     /locus_tag="VVO18_001094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280891.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein SMC"
                     /protein_id="HEU5586267.1"
                     /translation="MYLKEIEIQGFKSFADKTKVVFDQGVTAVVGPNGSGKSNITESL
                     RWALGESSVKSLRGGKMPDVIFAGTESRKPLNYASVVVTLDNHDGFIKDAGQEIRVER
                     HIYRSGDSEYKIDGKKVRLRDIHDLFLDTGLGRDSFSIISQGKVEEIFNSKPEERRAI
                     FEEAAGVLKYKTRRKETESKLQQTQDNLDRLEDIIYELDNQIKPLEKQAENARKFLDL
                     EGQRKAIYLDVLVAQIKENKAELESTEEELTQVQELLMSYYQKREKLEEENQTLKKQR
                     QDLQAEMAKDQGSLMDLTSLISDLERKLALSKLESEQVALNQQEAQARLAALEDKRNS
                     LSKEKSDKESSLALLEGNLVQNNQKLNRLEAELLAFSDDPDQMIELLRERFVALLQEE
                     ADVSNQLTRIENELENSRQLSQKQADQLEKLKEQLAIAKEKASQQKEELETAKEQVQK
                     LLADYQAIAKEQEEQKTSYQAQQSQLFDRLDNLKNKQARAQSLENILRNHSNFYAGVK
                     SVLQEKDRLGGIIGAVSEHLTFDMHYQTALEIALGASSQYIIVEDENAATKAIDFLKR
                     NRAGRATFLPLTTIKARTISSQNQDAIAVSPGFLGMADELVTFDTRLEAIFKNLLATT
                     AIFDTVEHARAAARQVRYQVRMVTLDGTELRTGGSYAGGANRQNNSIFIKPELEQLQK
                     EIAEEEASLRSDEVSLKNLQDELARLTERLEAIKSQGEQARIQEQGLSLAYQQTSQQV
                     EELETLWKLQEEEIDRLSEGDWQADKEKCQERLAAIASDKQNLEAEIEEIKSNKNAIQ
                     ERYQNLQEELAQARLLKTELQGQKRYEVADIERLGKELDNLNIEQEEIQRMLQEKVDN
                     LEKVDTDLLNQQAEEAKTQKTNLQQGLIRKQFELDDIEGQLDDIASHLDQARQQNEEW
                     IRKQTRAEAKKEKVSERLRHLQSQLTDQYQISYTEALEKAHELENLNLAEQEVKDLEK
                     AIRSLGPVNIEAIDQYEEVYNRLDFLNSQRDDILSAKNLLLETITEMNDEVKERFKST
                     FEAIRESFKVTFKQMFGGGQADLILTEGDLLTAGVEISVQPPGKKIQSLNLMSGGEKA
                     LSALALLFSIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKDSQFIVVTHRKGT
                     MAAADSIYGVTMQESGVSKIVSVKLKDLESIEG"
     gene            complement(26765..27463)
                     /locus_tag="VVO18_001095"
     CDS             complement(26765..27463)
                     /locus_tag="VVO18_001095"
                     /EC_number="3.1.26.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007522086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease III"
                     /protein_id="HEU5586268.1"
                     /translation="MKELQTVLKNHFAIEFTDKNLLETAFTHTSYANEHRLLKISHNE
                     RLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKL
                     GKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
                     YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQE
                     AAKNAVEKGLDSCI"
     gene            complement(27646..27717)
                     /locus_tag="VVO18_001096"
     tRNA            complement(27646..27717)
                     /locus_tag="VVO18_001096"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(27682..27684),aa:Arg,seq:ccg)
     gene            complement(27781..28767)
                     /locus_tag="VVO18_001097"
     CDS             complement(27781..28767)
                     /locus_tag="VVO18_001097"
                     /EC_number="1.7.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516839.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GMP reductase"
                     /protein_id="HEU5586269.1"
                     /translation="MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVV
                     PANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEY
                     DFVRQLKTDAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
                     AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIA
                     KSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRIL
                     LPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH"
     gene            complement(28942..30258)
                     /locus_tag="VVO18_001098"
     CDS             complement(28942..30258)
                     /locus_tag="VVO18_001098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001223073.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrC family protein"
                     /protein_id="HEU5586270.1"
                     /translation="MRITDNQHKIIKEKFVEEYPKLSNLLLDRTLESLSQDERIFIFP
                     NDLTHTPDLDKDQKIFETVNQKIKTGNVIGFLGYGQERLTISSRFSDESNDHFLHYLL
                     NKVLYINLTSLDVALSREERLYQLLMYLFPKYLQAAIRKGLYKEYHRFSHNDSHVKGV
                     IDVRNHLKKNLPFTGNIAYTTREFTYDNPLMQLVRHTIEYIKNQKSIGQGVLDNLSTS
                     RENVSEIVRVTPSYKLADRAKIIRGNQSKPIRHAYFHEYRNLQELCLMILNQEKHGLG
                     YQDQKIYGILFDVAWLWEEYVYTLLPKGFVHPRNKDKTDGISVFFVGKRKVYPDFYDR
                     ERKIVLDAKYKKLELTEKGINREDLFQLISYSYILKTEKAGLIFPSMEQSVNSEIGKV
                     AGYGAQLKKWSIRIPQNASSYSAFCKMMENSEENFKAIIDEEVGRK"
     gene            complement(30245..>31744)
                     /locus_tag="VVO18_001099"
     CDS             complement(30245..>31744)
                     /locus_tag="VVO18_001099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042398.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="McrB family protein"
                     /protein_id="HEU5586271.1"
                     /translation="KRSTNEFIGRSAMVTKLLCIYSEGDPFFGVNINSQKEFWNHFVS
                     QTNQGGPYLQNHKIIELVSKTYPELEPSKLGTMLFEYSKLFMENKEDNSTMDSSNNFR
                     HQLTQSLLKSPNLILRGAPGTGKTYLAKEIAKELTDGNEDQIGFVQFHPSYDYTDFVE
                     GLRPVSNGDGAIEFRLQDGIFKDFCQKAKETQLIGGQDNFDEAWDSYLEYINVAEEKE
                     YITKTSYLSVNSRQNLSVNYDSGVPGWSLPSKYVYELYKDKNYNKQEYYKSGGKTVLE
                     TLRKRFGLKDYVSPTEIDTDKKFVFIIDEINRGEISKIFGELFFSIDPGYRGEKGSVS
                     TQYANLHETDEKFYIPENVYIIGTMNDIDRSVDTFDFAMRRRFRFVEVTAEGQVGMLD
                     KELNIHAEEAKIRLRNLNAAIENVQELNSHYHIGPSYFLKLKDVDFDYELLWSDYIKP
                     LLEDYLRGSYDEVETLETLKKAFELTNNEQKDQAVADDNEGDENDDADY"
BASE COUNT         9306 a         7056 c         5623 g         9759 t
ORIGIN      
        1 atacatcttc ccacaataaa acgcatagta tcaagttttt atacctgata atatgcgttc
       61 tattgtgtca aaacttactt gatttctcct cagttcaaac tttttctcat ctttattttt
      121 attatgtttt ttcaatcaaa tcttgtatca ttttatgtag ttcttctatc tttttagatt
      181 gtttctctag taatattctc ggactagata attcatcttg gagtttatca agttttatct
      241 gttcatctgg attatccttt acaaaaaagt tcgtcaaagc acttgttaac atccctattg
      301 ttccaatacc gacaagcatc agtaaaactg ctagccattt ccccaaaagg gaaactggaa
      361 caatatcacc ataaccaaca gtagttactg tcacaagagt ccaccaaaga ctatctgaga
      421 aggatttttc ttcaactaca gataaaattg aacttcctac tagaataata aagatattaa
      481 catataagat ataaatcagg ccatttgtcc gtaagaatct actaattttt ctttctaatt
      541 tacctgtaag tccaattatt ctaagtaaac gagtcagttt cagtaatttt gttagtttaa
      601 ctaaacgaaa gatacgccct aatcgaaaaa ctgtgaaaat agcatttaaa gggagaatag
      661 ccaataaatc aaaaacattt tcaagaataa agcgccattt tcttttagta ataaaaaagc
      721 gccaactata atcaattaca aaaacacccc agattactaa atcaataata ctataaggcg
      781 gattgtccaa atcaatcatc tcagcaaatc caagtaatac cagaataaca gagattaaag
      841 caagtaaaat aattgttgta tcataataat ctgcaaaaaa ccattttttc ttcaaatttt
      901 tactctcctt actttctata ttgttattac tcagctttaa ttcaataaat atctctccga
      961 tgaccaactt ctagagtagc aacaactaat tcatcatcta caatttgtac gataactcga
     1021 taattaccaa ttctatagcg ccattgacca acgcgattac caaccaaagc ctttccgtgt
     1081 cgtcttgggt cttccaaaac attgatttgt aaatagtttg taattagctt ctgcgtataa
     1141 cggtccaatt ttttcaattg cttgatgaaa cgtcttgttg gaactaattt atacaaatta
     1201 ttcatccttc aagcctaaat catgcatcat ttcttcccaa gtaatgggtt caactccttt
     1261 ttccaagtct tctaaatact cttgataggc taaatctgcc acacgagcat cgtattcatc
     1321 ttctagggct tcaagagttt tggtgcgaat aagttccgaa agggaaactc cttcaaactt
     1381 agccattgct ttcataaatg ttttatcagc ttcagaaact tttaatgtaa tagtagtcat
     1441 cttttgtgct ccctttttta atggtaacac cattgtatta ctttttaggt gttcagtcaa
     1501 tataaaaaga acaccttctc agcgttcttt ctatatctct gtcaatggtg ttgcggtatc
     1561 tggtgaggta tcataaacct taaagtctac tccgactccc agatcagctt gagccagctg
     1621 attgaccatg gtcatatgag ccagttcctt gatattgttt tccttagata aatgcccaag
     1681 gtaaatcttc ttagtacgat ttcctagcgt ccgaatcata gcttcagcac cgtcctcgtt
     1741 agaaaggtga ccaaggtcag ataggattcg ttgtttgagt cgccaagcgt aagaacctga
     1801 tcgcaaaatc tctacatcat ggttggcctc gataagatag ccatccgcat tttcgacaat
     1861 gcccgccata cggtcactga cataacctgt atctgtcaaa aggacaaaac tcttatcatc
     1921 cttcataaag cgatagaact gcggtgcgac tgcatcatgg cttacaccaa aactctcgat
     1981 gtcgatatct ccaaaggttt tggttttacc catttcaaaa atatgctttt gcgaagaatc
     2041 caccttgcca agatatttac tattttccat agcttgccag gtcttttcat tggcataaag
     2101 atccatacca tacttgcgag ccaaaacgcc tactccatgg atatgatctg aatgctcatg
     2161 ggtaatcaag atggcatcca ggtcttctgg cttacggtta atttcagcta gcagactggt
     2221 aattttcttg ccagacaagc ctgcatctac taaaagcttc ttttttgagg tttccagata
     2281 aaaagaattt ccactggaac ccgacgctaa aatactgtat ttaaagccta tttcactcat
     2341 tctagtcttc tacttcatcc tcccatactt cttctttcac tgcatcctta tcataaggga
     2401 gcacaatggt aaaggttgaa cccttgccgt attcactctt ggcccaaata aagcccttat
     2461 gttgtttgat aatttcttta gcgataaaca gtcctagacc tgtaccacct tgtgcacgac
     2521 ttctagcacg atccacacga tagaaacggt caaagatacg tggtaaatcc tgcttaggaa
     2581 tccccaaacc gtggtcagaa atggataaaa tcatctggtc ttcagttgtc ttcattctga
     2641 cagtgatttt acccccatct ggcgaatact taatagcatt atttaaaata ttgtcgacaa
     2701 cctgcgtcat cttatctgta tcaatttcca tccagataga attgatggga taatctctca
     2761 ccaactcata ttttttctcc ttttcctgtc ctttcatctt gtcaaaacga ttgaggataa
     2821 aggtaataaa agcagtgaag ttaatcagtt ccacatctag gtgactggta gcattatcaa
     2881 tacgtgaaag atggaggaga tccgtcacca tgcgcatcat acggttggtc tcatcaagag
     2941 aaaccttgat aaagtctggt gctacagttt cacacaaagc cccctcatcc aaggcttcaa
     3001 gataggattt tacgctagtc agaggagtcc gtaactcatg gctaacattg gaaacaaaga
     3061 gtcttcgttc gcgttcttcc ttctcctgct ccgtcgtatc atgcaaaaca gccaccaaac
     3121 ctgaaataaa gccagactct cgacgtatca aggcaaagcg aactcgaagg ttcaaatatt
     3181 cgccattgat atcttgggaa tctagcaaca attctggact ttgggtaatc aaatcacgca
     3241 attcatagtt ttcttctatc ttgagcaatt ccaaaatgct tctattcaga acatcttcct
     3301 taaccaaccc cagttgcttc ttggctgtat cgttaatcat gataatctga ccccgacggt
     3361 tggtcgcaag aaccccatct gtcatataaa acagaatact atttagcctc ttactctctt
     3421 gttctagatt ttcctgagtg agacgaataa cctccgacaa gtcattcaaa ttattggtaa
     3481 tattggtgat ttcagaccca ccttgcatat caagaacctt ggaataatct cctgcaatca
     3541 aatctttaac cttttgattg atttgcttca actgaatatt atcacgtcta ttttccagta
     3601 ataagagggt cacaacaagg atgaaaccta acaaaatcag gataaagata aaatctctgg
     3661 taaaaatggt ttgtttcagt aaatcaagca ttatttctca tgtaataccc tacaccacgg
     3721 cgcgtcaaga tatactctgg tcggctgggc gtatcttcaa tcttctcacg cagacgtcgt
     3781 acagtcacat caactgtacg gacatcacca aaatagtcat aaccccagac agtctcaagc
     3841 aagtgttcgc gcgtgatgac ttgacctgta tgcgatgcta aatgatacaa aagctcaaat
     3901 tcacgatggg ttaagtctag ttcttcgcca tattttttag ccacgtaggc gtctggaaca
     3961 atttctaaat ccccaatttg gataggttga ggtttactat ctgcttcctg accatctact
     4021 ggcataggtt gagaacgacg cagaagagct ttaacacgcg cctgcaactc acgattggag
     4081 aagggtttcg ttacatagtc atctgcccca agttccaaac cgataacctt atcaaattca
     4141 ctatctttgg ctgaaagcat aagaatgggc acactgcttg tcttacgaat ggtcttagca
     4201 acttctaaac catcaatttc tggaagcatc aaatccagaa taataatatc tggttgctct
     4261 gcttcaaatt gctctagcgc ttcacgacca ttaaaagcag ttacaacttc gtaaccttcc
     4321 ttggtcatat taaacttgat aatatccgag attggtttct catcatctac aattagtatt
     4381 tttttcatat gttcaccttt ttctctacta ttataccaaa aaatagtcag aagacacaat
     4441 agctagtctt ggctactgtc taagttggct tgtgcataag cctgccagat tttttgttgg
     4501 ggtttggcaa gtgggtaatt cttgaattct tctggtgaaa gccaacgaac ttccctatct
     4561 gaaaaatcat ggaagtcact cacctgacct gctacaatct gtacatgcca ttttcgatga
     4621 ctaaaaacat gctggactgt atcaaaacaa acatcaagcc aatcaacatc taggtcatag
     4681 tcctgctgga aactctcttc tggactgggg ccagagttca cactttcttc cgcaacctga
     4741 tgaaagaggt caaactgctc ttcttgcgaa aagttatcaa cttctataaa ggggaaatgc
     4801 caaaaacctg ccaagagctt ttcgctttca tttttttcaa gtaaaaattg tccttgagaa
     4861 tttttcacaa ctaaggcttt aagataaata ggaaccggct ttttcttagg agatttaatt
     4921 ggataacggt ccatggttcc attctgatat gccgcactaa agtccttgac tgggctttct
     4981 tcaggtctgg gatttacagg agactcaata tcagacccta agtccatcaa ggcttgatta
     5041 aaatcacccg gacgatctgg attaatcaag atctccatca ttgcctgaaa aatttttcga
     5101 ttacttggaa tcccaatatc gtggttgact tcaaacagac gcgccaagac ccgcatgaca
     5161 ttaccatcta cagctggctc aggcaagtta aaagcaatac tggaaatggc tcctgctgtg
     5221 taaggtccaa tccctttcaa gctggaaatt ccttcatagg tatttggaaa ttggccacca
     5281 aagtcagtca taatttgctg ggctgcagcc tgcatattgc gaactcgaga ataataaccc
     5341 aagccctccc aagctttcag taaactctcc tcaggcgcag ttgccagact ttcgacagtt
     5401 ggaaaccagt ccaaaaatct ttcgtagtaa gggataactg tatccaccct ggtctgctga
     5461 agcatgattt cagataccca gatgtgataa ggatttttac ttctcctcca aggcaaatct
     5521 cttttgtttt catcatacca agcgagaagt ttctcacgga aagaaatgac tttctcctcc
     5581 ggccacatga cgataccgta ttctttcaaa tctaacatat ctctagtata acacagaagg
     5641 tttcacctgt ctttgtatct gatttataat attttcaata gatagtatat aacttttcta
     5701 tctacttata ctcaatgaaa atcaaagagc aaactaggaa gctagccgca ggttgctcaa
     5761 aacactgttt tgaggttgtg gatagaactg acagagtcag tatcatatta cctacggcaa
     5821 ggtgaagctg acgtagtttg aaaagatttt cgaagagtat aaatcttatt gatgaactgc
     5881 ttgcagtctg agaaaaaatg agcttggata ttatttccaa actcacttaa agtcaatttc
     5941 aatccactag aacaagccta gtacagttcc atcgctttca acatccatgt tgagagctgc
     6001 tggacgtttt ggaagacctg gcatggtcat aacatcacca gttaaggcaa cgatgaagcc
     6061 tgcacctaat tttggtacca attcacgaat ggtaatttca aagttttctg gtgctccaag
     6121 cgcatttgga ttgtctgaga aactgtattg agttttagcc atacaaattg gcaatttgtc
     6181 ccaaccgttt tgaacgattt gagcaatttg tgtttgagct ttcttctcaa agttcacttt
     6241 gctaccacga tagatttcag tgacaatttt ttcaatcttt tcttggacag aaaggtcatt
     6301 atcgtacaaa cgtttatagt tagctggatt ttcagcaatt gtcttaacaa ctgtttcggc
     6361 aagtgctact ccaccttctg ctccatcagc ccagacacta gccaattcaa ctggtacatc
     6421 gattgaggca cagagttctt ttaaggctgc aatttcagct tctgtatcag atacaaattc
     6481 gttaatagct acaactgctg gaataccgaa cttacggata ttttcaacgt ggcgtttcaa
     6541 gttagcaaaa cctgcacgaa ctgcctctac attttcttca gtcagagcgt ctttagccac
     6601 accaccattc atcttaaggg cacgaagggt tgcgacaata acaactgcat ctggagatgt
     6661 tggcaagttt ggtgtcttga tatcaaggaa tttctcagca ccaaggtccg caccaaaacc
     6721 agcttcagta acagtgtaat cagccaagtg aagggctgtt gtcgtcgcca aaacagagtt
     6781 acagccatga gcgatattgg caaatggacc accgtgtaca aaggcaggtg taccgtaaat
     6841 tgtctgaacc aagtttggct taatagcatc cttcaaaatc aaagccaagg caccctcaac
     6901 ctgcaaatca cctacagaaa caggcgtacg gtcatagcga taaccaataa cgatattcgc
     6961 caaacgacgt ttcaagtcct cgatgtccgt tgccaagcaa agaattgcca tgatttctga
     7021 agcaactgta atatcaaaac catcctcacg tggaataccg tttagaggac caccaagacc
     7081 aacagtcaca tggcggagcg cacggtcgtt caagtccaca acgcgtttcc agaggatacg
     7141 acgttgatca attcccagct cattcccttg gtgcaagtgg ttgtcaatca aggcagaaag
     7201 ggcattgttg gcagttgtaa tagcatgcat atctccagta aagtggaggt tgatgtcttc
     7261 cattggcaga acttgtgcat acccaccacc agcagcacca cccttgatcc ccatgactgg
     7321 accaagagac ggttcgcgga tagcaatcat ggttttcttg ccaatcttgt tcaaggcatc
     7381 cgcaagacca atggtaagcg tcgactttcc ttcacctgca ggtgttgggt tgatggcagt
     7441 aaccaagatc aatttaccga ctggattgct ctcaactgca cgaattttat caaagctgag
     7501 tttagccttg tactttccgt acaactccaa atcgtcgtaa gaaataccaa gtttctctac
     7561 aacatcaaca attggcttca actcaatact ctgtgcgatt tcaatatctg ttttcattca
     7621 aaattcctct aacctcttat atgataattc attatatcac aaaacaagat ttttaacatc
     7681 ctaaaactct ctaaacgttc gtaaatatct ctgtttttaa gacttttaga gtcctttctt
     7741 aaattttata tggctttata gtttgaaact ataataaatt ttcgttttta ccaaaaattt
     7801 atcactttca ttttacttac cgcttatttt tgtgtacaat agtgctatga aaattttagt
     7861 tacatcgggc ggtaccagtg aagctatcga tagcgtccgc tctatcacta accattctac
     7921 aggtcacttg gggaaaatta tcacagagac tttgcttttt gcagggcatg aagtttgttt
     7981 aattacgaca aaacgagctc tgaagccaga gcctcatcct aacctaagta ttcgagaaat
     8041 taccaatacc aaggaccttc taatagaaat gcaagaacgt gttcaggatt atcaggtctt
     8101 gatccactca atggctgttt ctgactacac tcctgtttat atgacagggc ttgaggaagt
     8161 tcaggctagc tccaatctaa aagaattttt aagcaagcag aatcatcagg ccaagatttc
     8221 ttcaactgat gaggttcagg ttttgttcct taaaaagaca cccaaaatca tatccctagt
     8281 caaggaatgg aatcctacta ttcatctgat tggtttcaaa ctgctggttg atgttaccga
     8341 agatcatctg gttgacattg cacgaaaaag tcttatcaag aatcaagcag atttaatcat
     8401 cgcgaatgac ctgactcaaa tttcaacaga tcagcaccga gctatatttg ttgagaaaaa
     8461 tcagcttcaa acagtccaga ctaaagaaga aattgcagaa ctcctccttg aaaaaattca
     8521 agcctatcat tcttagaaag gaaaactatg gcaaacattc tcttggctgt aacgggttca
     8581 atcgcctctt ataagtcggc agatttagtc agttctctaa aaaaacaagg ccatcaagtc
     8641 actgtcttaa tgactcaggc tgctacagag tttatccaac ctttgacact acaggtactc
     8701 tcacagaatc ctgtccactt ggatgtcatg aaggaaccct atcctgatca ggtcaatcat
     8761 atcgaacttg gaaaaaaagc agatttattt atcgtggtac ctgcaactgc taacactatt
     8821 gcaaaactag ctcacggatt tgcggacaac atggtaacca gtacagctct agccctacca
     8881 agtcatattc ccaaactaat aactcctgct atgaatacaa aaatgtatga ccatccagta
     8941 actcagaata atctgaaaac attagaaacc tacggctatc agctgattgc tcctaaggaa
     9001 tccctactag cttgtggaga ccacggacga ggagctttag ctgacctcac aattatttta
     9061 gaaagaataa aggaaactat cgatgaaaaa acgctctaat attgcaccca ttgctatctt
     9121 ttttgctacc atgctcgtga tacactttct gagctcactt atctttaacc tttttccatt
     9181 tccaatcaaa ccgaccattg ttcatattcc tgtcattatt gccagcatta tttatggtcc
     9241 acgagttggg gttacacttg gatttttgat gggattactt agcttgacgg ttaacacgat
     9301 tacgattcta ccgacaagct acctcttctc tcccttcgta ccaaacggaa acatctactc
     9361 agctatcatt gccattgtcc cacgtatttt gattggttta actccttact tagtctataa
     9421 actgatgaaa aacaagactg gtctgatttt agctggggcc cttggttcct tgacaaatac
     9481 tatctttgtc cttggaggaa tcttcttcct atttggaaat gtttataatg gaaatatcca
     9541 acttcttctg gcaaccgtta tctcaacaaa ttcaattgct gaattggtca tttctgcaat
     9601 tctaacccta gccattgttc cacgactaca aaccttgaaa aaataaaaac aatctccgct
     9661 ttcaaacctg aaggtggaga ttttgctcta tacagtttct ttttaatgaa atctttacta
     9721 tagtaaaacg aaataagaac aggacaaatc gaacaggaca aatcgatcag gacagccaaa
     9781 tcgatttcta acaatgtttt agaagtagag gtgaactatt ctagtttcaa tctactataa
     9841 cttttaacta aaaaatgatc tataaaccca agtaaattct tgctttattg tctggtttat
     9901 tgtaccatac tagtgtatat gcagttaaaa aggagattct tgtgaataca cggaaaaaga
     9961 cacaatttat gacaatgaca gcccttttaa cggctattgc gattttgatt ccaattgtta
    10021 tgcctttcaa gattgtcatt ccacctgctt cctatacttt ggggagccac atcgctattt
    10081 ttatagccat gttcttgtcg cccttgatgg cagtttttgt catcctagcc tctagttttg
    10141 gatttttgat ggctggctat cccatggtta tcgtttttag ggctttttcc catatatctt
    10201 ttggtgcttt aggagctctt tacctacaaa aattccccga taccctagat aaaccaaaat
    10261 cttcctgggt tttcaacttt gttttggctg ttgttcatgc ccttgctgaa gtattagcct
    10321 gtgtcctttt ttacgcaact tcgggtacca atgtagaaaa catgttctat gttctatttg
    10381 tactagttgg atttggcaca attatccata gtatggtaga ctatacatta gcactagctg
    10441 tctataaagt gcttcgaaaa cgccgttaaa aggaaaagct atgacaaaag atcgcaaaca
    10501 agccctgctc caactcttga aagaagctcc taaagccctt aatggccaaa gtttggcgga
    10561 acattttcat gtcacacgtc aggtcattgt gcaggacatt gcaattttga gagccgatgg
    10621 cgctcctatc ctatccacca atcgtggcta catctataag caaattgata ccaatcctta
    10681 tgttcacaaa cttttcaaag tgaaacatga agttgaagaa atcggtcagg aactccttgc
    10741 tattgtcgat aatggcgggc atgtccagaa taccttgatt gaccatcccg tttatggaga
    10801 aattgaaacc ttgcttaaac tgtcttgtcg cagagatgtg caacattttc tagaacaagt
    10861 cgagcattct gactttagac ctctatctga attgacagat ggcgtccatt accacctagt
    10921 cgaagccgaa acacaacaag acctccacta tatcgaggag gccttggatc agctaggtta
    10981 tttagtaaaa gactaaaaaa tttctttctc ccaatcgtct tctgtacggc gagggtagaa
    11041 aaattcagat ttgtccggag cttccatcat ctccatcaaa ggtagcatat cataggccag
    11101 atccaagttt ggaatctggt ctttttgaat ccaagaaacc tctccttcat ctgaagagcg
    11161 aagggtacca gagaactcag tcgccttata acaaacgaca atatagcgcc cacctgtatc
    11221 tagtggccaa tttttaatgc cgacaagttg aggattttgg atagtcaacc ctgtttcttc
    11281 atagatttca cgaatgacag actctgcgaa agattcgcca ttttctacat gacctcctgg
    11341 aaaggcataa cctgaccagc gattggtgtc aggagagcga tactgcatga ctacgcgctg
    11401 agtttcgagg tcttcaatca gacagatatt tgttaaaatt gttaattggg aacgggacat
    11461 aaatttactc gctttctaag ttattaaatt tttagacttg gtaccagtgc catgagcttc
    11521 tactttttaa aattatttag aatagaatac catccgtttt tcctttatag gctttccaag
    11581 ttcaagtatt ttttcttgtc catcaaaagt ataacccatt ttttgataga aagcaatggc
    11641 gcgcttatta tctttcaata cccataagaa aatttcagaa aaatgatcaa gagcagtcaa
    11701 agctgctttc attaactttt gtgcgatgcc ttttccgtaa tagtctttta aaacatataa
    11761 agcaataatt tcaccagctt gaatagtctc atcacgaaag ttgccataac tgataaaacc
    11821 aactaccttc aggccatcca tcgcaatcaa tgtattttct ggatactttt gactaaagag
    11881 tcgacacctt tctaatgtca tcgtctcttg aaattctgca ggcaaaaggt cgtcataaga
    11941 ttctctccac gctttccagt gaacaaggga tttaccttct atctcttcag gagtttccat
    12001 ctgtttgaca gtgatgacca tttgcttcct cccattcttc tctcaaaatg ccgtatttaa
    12061 tactatcata ataaacacct tgataataac gaacttttgg aatatgagct tcttttttca
    12121 ttcttaattt ttcagccaat ttcatcatac caaaatttcc tgaccaagtt gtcaaaccca
    12181 gatgctccaa ctccaagtaa tcctgaaacg tcctatctat ccactgcaac atagcaactt
    12241 tcccaatacc agtgttccag aattttttat cataaatacc aattcccaat tccatccatc
    12301 ttgtttgttt acatacccaa taacgcgaaa cagtcccaac tagtttatca tcaacaaaaa
    12361 taccaaggcg atttgagttg cttaaaatgg attctgattt ttgtagttcg aattctttaa
    12421 aatttgaaaa atactgataa tcatcataat agggagcatc atactgtttc caaactggat
    12481 taagttgtga ataagccatt tcccataaag acatcaaatc ttctttcttt aactttctta
    12541 aataaatcat actattcccc taatccaacg ccttcacttc cagcatcata tcacgaatct
    12601 gagctgctag ttcaaagtca agcacttcga cggcttcttg catttgtttt tcgagtttct
    12661 taacaagttc tttgcgctct tgtttgttga ggctattgat atcaacttcc ttgtcttctt
    12721 ccttagaaac tgccttggtc acagcaatca ggtcacggat ttctttcttg attgtctgtg
    12781 gtacgatacc atgctcttca ttataggcca tctggatttt gcgacggcgg gcagtttcat
    12841 cgatagcacg ttgcatagac tgggtaaccg tgtccgcata catgataaca tgaccttcac
    12901 tgttacgggc ggcacgtcca atggtctgga tgagtccacg ttcgttacga aggaaacctt
    12961 ccttgtcagc atcaagaatc gctacgaggc tcacttcagg aacgtcaatc ccttcacgaa
    13021 ggaggttgat tccgaccaag acatcaaaga cacccaagcg caggtcacgg ataatctcag
    13081 tccgctccaa tgtcttgata tccgagtgca tgtacttgac cttgataccc atttccttga
    13141 agtagtcggt caagtcttct gccattttct tggtcaacgt ggtgataaag gttcgttcgt
    13201 tcttctcaac acgagcatta atttcaccta agaggtcatc aatctgtccc atagtcggac
    13261 ggacttccac ctctggatcc aagagtcccg ttggacgaat gatttgctca atcactgtct
    13321 cagtctgttc attttcatag tcaccaggtg tcgctgaaac gtaaacaatc tggtgcacat
    13381 ggctttcaaa ctcctcccga cggagaggac gattgtccag agcagacggc aaacggaaac
    13441 cgtaatttac taacatttcc ttacgagaac ggtctccatt gtacatgccc ttgatttgtc
    13501 ccatggtcat gtggctctcg tcaatcatga ttaagaaatc atctggaaag aaatcaagaa
    13561 gtgtgtaagg aggctctcct tcgctccgtc catccatgtg acgtgaatag ttctcaaccc
    13621 cgttggtata gcccatctca cgcagcattt cgatatcgta ctctgtccgt tgtttcaagc
    13681 gctgggcttc aagcagtttg ccttcctttt caaagacagc tagttgctct tctaattctg
    13741 cttgaatctt ggcaatagca acttccatgt ggtcgtcatt ggtcacaaag tgagtcgcag
    13801 ggaaaatcgc taaatgatcc acttctccaa ggacttgacc tgtcaaagct tcaacctcac
    13861 gaatacggtc aatttcgtct ccaaaaaatt ctactcgaaa agcgtgttca tcacgggaag
    13921 cagggaaaat ctccaccaca tccccacgaa cgcgaaatct tccccgttgg aaatcaatat
    13981 catttcgctc aaattggata tccaccaagt cattcaagag tttatcacgg gaaatttcaa
    14041 gacctggacg gagactaacg acactatcag cgtattcctt gggcgaaccc agaccataga
    14101 tacaagagac cgaggccacg acaataacat cattgcgctc caatagggct gaagtcgctg
    14161 agtgacgaag cttgtcaatc tcgtcattga cagaactatc cttctcaata taggtatcac
    14221 tagaagggac ataggcttct ggctggtaat agtcatagta ggatacgaag tactcaactg
    14281 cattttcagg gaaaaattcc ttgaactccc catagagctg accagccaga gttttattgt
    14341 gggcaatgac tagagtgggt ttattgactt tggaaatgac ctgactcatg gtataggtct
    14401 tccctgttcc ggtcgccccc atcagaatct gagctttttc tccaccctcg atattatcta
    14461 ccaactgctc gatagcttgg ggttgatctc ctgatggttg atattttgat actagtttaa
    14521 atttattatc tgtaatgcgg ttaatcataa gaatcctctc tccatgtgct attcctattt
    14581 tagcatactt gtatcatttt cacgaagaaa aggacgaacc gaagtcacat cctttcattt
    14641 tctttcttta attggtaagc gagataaaga atcagcagaa acaaaataat actggacacg
    14701 atggaaccct caataccaaa agacccacca gatagccagt cttgattgcc ttgtggagta
    14761 aatttcatga ttgaggttcc tgaagactga ccactaacta atactccaaa gaggttgccc
    14821 tgtgcgaaat tccaagctcc atgaatacca cctatacccc atatagtatc tgttttaaga
    14881 agatataggg acatggcaac cccaaataaa aagagatcaa ttgcagataa gaaagttatg
    14941 cctggatttc ctaaatgaag taaggtaaag agactactag atatgataat agcgacttta
    15001 agattggttc tcttagccaa ttgtggaatc agccaagcac gagtaaccaa ttcttctgcc
    15061 gttccttgta aaatccaaaa aggtattgta aataaagtaa aagctagcga ataagtatcc
    15121 aagtgaatgg agtccaaacg atattgccct aaggccacca aacctaacaa ggtcagaaga
    15181 aaaagtgcca gacctagact aaatcctttc agaagattgc tgaggaaatt ctctctataa
    15241 aatcccaagg ttcgaatagg tcttttctca acttttcttg tccatctgaa cacagtgtta
    15301 agaataaaac caaaggccag taatcctaaa attaaacgaa agtcacttgt tttatccgtc
    15361 aagctctgat gcaaggtctg caagtagctt gcaagatttt gaccagcctc tccaaaattt
    15421 ctagcaagtc cgatgagagc taacaagcca ataccataca aagtaaaagc cacaaactct
    15481 cctatgaaga caaaaacaaa ggctaacaag gggcttgtgt aaatgtttaa actcattttt
    15541 gaagcttgga agtctttaaa tattcttttg ttcttcatat ccccgtcctc ttttcttcta
    15601 tatatactat tattatagca ctttttaata gcaattcaag gaaaggaaaa aatcaatgtt
    15661 atattttctg acacgaaaaa tataaaaatt tgcctttttt tactttttct gatataatga
    15721 gagaatattc ggaaaaggag actaaaaatg aagaaaaaat ttctagcatt tttgctaatt
    15781 ttattcccaa ttttctcatt aggtattgcc aaagcagaaa cgattaagat tgtttctgat
    15841 accgcctatg caccttttga gtttaaagat tcagatcaaa cttataaagg aattgatgtt
    15901 gacattatta acaaagtcgc tgagattaaa ggctggaaca ttcagatgtc ctatcctgga
    15961 tttgacgcag cagtcaatgc ggttcaagct gggcaagccg acgctatcat ggcagggatg
    16021 acaaagacta aagaacgtga aaaagtcttc accatgtctg atacttacta tgatacaaaa
    16081 gttgtcattg ctactacaaa gtcacacaaa attagcaagt acgaccaatt aactggcaaa
    16141 accgttggtg ttaaaaacgg aactgccgct caacgtttcc ttgaaacaat caaagataaa
    16201 tacggcttta ctattaaaac atttgacact ggggatttaa tgaacaacag cttgagtgct
    16261 ggtgccatcg atgccatgat ggatgacaaa cctgttatcg aatatgccat taaccaaggt
    16321 caagacctcc atattgaaat ggatggtgaa gctgtaggaa gttttgcttt cggtgtgaaa
    16381 aaaggaagta aatacgaaca cctggttact gaatttaacc aagccttggc tgaaatgaaa
    16441 aaagatggta gtcttgataa aattatcaag aaatggactg cttcatcatc ttcagcagtg
    16501 ccaactacaa ccactctcgc aggattaaaa gctattcctg ttaaggctaa atatatcatt
    16561 gccagcgatt cttcttttgc accttttgtt ttccaaaatt caagcaacca atacactggt
    16621 attgatatgg aattgattaa ggcaatcgct aaagaccaag gttttgaaat tgaaatcacc
    16681 aaccctggtt ttgatgctgc tatcagtgct gtccaagctg gtcaagccga tggtatcatt
    16741 gctggtatgt ctgtcacaga tgctcgtaag gcaacttttg acttctcaga atcatactac
    16801 actgctaata ccattcttgg tgtcaaagaa tcaagcaata ttgcttctta tgaagatcta
    16861 aaaggaaaga cagtcggtgt taaaaacgga actgcttctc aaaccttcct aacagaaaat
    16921 caaagcaaat acggttacaa aatcaaaacc tttgctgatg gttcttcaat gtatgacagt
    16981 ttaaacactg gtgccattga tgccgttatg gatgatgaac ctgttctcaa atattctatc
    17041 agccaaggtc aaaaattgaa aactccaatc tctggaactc caatcggtga aacagccttt
    17101 gccgttaaaa aaggagcaaa tccagaactg attgaaatgt tcaacaacgg acttgcaaac
    17161 cttaaagcaa acggtgaatt ccaaaagatt cttgacaaat acctagctag cgaatcttca
    17221 actgcttcaa caagtactgt tgacgaaaca acgctctggg gcttgcttca aaacaactac
    17281 aaacaactcc ttagcggtct tggtatcact cttgctctag ctcttatctc atttgctatt
    17341 gccattgtca tcggaattat cttcggtatg tttagcgtta gcccatacaa atctcttcgc
    17401 gtcatctctg agattttcgt tgacgttatt cgtggtattc cattgatgat tcttgcagcc
    17461 ttcatcttct ggggaattcc aaacttcatc gagtctatca caggccaaca aagcccaatt
    17521 aacgactttg tagctggaac aattgccctc tcactcaatg cggctgctta tatcgctgaa
    17581 atcgttcgtg gtggtattca ggccgttcca gttggccaaa tggaagccag ccgaagcttg
    17641 ggtatctctt atggaaaaac catgcgtaag attatcttgc cacaagcaac taaattgatg
    17701 ttgccaaact ttgtcaacca attcgttatc gctcttaaag atacaactat cgtatctgct
    17761 atcggtttgg ttgaactctt ccaaactggt aagattatca ttgctcgtaa ctaccaaagt
    17821 ttcaagatgt atgcaatcct tgctatcttc tatcttgtaa ttatcacact tttgactaga
    17881 ctagcgaaac gcttagaaaa gaggattcgt taatggcaaa attaaaaatt gatgtaaatg
    17941 atttacacaa gcactatgga aaaaatgaag tcctaaaagg aattacgact aagttctatg
    18001 aaggagatgt tgtttgtatc atcggtcctt caggttctgg taagtcaact ttcctccgta
    18061 gcctcaatct tttagaagaa gtcactagcg gtcacatcac tgtgaacggc tatgatttaa
    18121 ctgaaaaaac aaccaatgtt gaccacgtcc gtgaaaatat cggcatggta ttccaacact
    18181 tcaacctctt ccctcatatg tctgtattgg acaacatcac ctttgctcct attgagcaca
    18241 agttgatgac taaggaagaa gctgaggaat tgggaatgga gttgcttgaa aaggttggac
    18301 tagcagataa agctaatgcc aatccagata gcctatcagg tggtcaaaaa caacgtgtgg
    18361 ccatcgctcg tggcctagca atgaatccag acatcatgct cttcgatgaa ccaacttctg
    18421 cccttgaccc tgagatggtt ggagacgtac ttaacgttat gaaggaattg gctgagcaag
    18481 gcatgaccat gattatcgta acccatgaga tgggatttgc tcgtcaggtt gccaaccgcg
    18541 ttatctttac tgcagatggc gagttccttg aagacggaac acctgaccaa atctttgata
    18601 acccacaaca ccctcgtctg aaagagttct tagataaggt cttaaacgtc taaactcaaa
    18661 ctgtaaggat ttccttgcag tttttctacc tcgtattgga atttttgatt tttcggaaaa
    18721 ttatgttaga attaagttta tgaaatgagg tttcctcata cctagcaaga ctaggaataa
    18781 aaatagaaat taggtagcta gatgtcatct aaggttattg ttacaatttt cggtgcgagt
    18841 ggagacctgg ctaaacgcaa gctctaccct tcccttttta gactatataa atccggcaat
    18901 ctttccaagc actttgccgt tattggaact gcccgtagac cttggagtaa ggaatatttt
    18961 gaatctgtag ttgtcgagtc catccttgat ttggcagata gtaccgagca agcccaagaa
    19021 tttgctagcc acttctacta tcaaagccat gatgtcaatg attcggaaca ttatattgct
    19081 ttgcgtcaat tacaagctga gcttaatgaa aaataccaag ctgaacacaa taagctcttc
    19141 ttcttgtcta tggcacctca gttctttgga accattgcca aacacctcaa atctgaaaac
    19201 attgtcgatg gcaaaggttt tgagcgcttg atcgttgaaa aaccatttgg tacagattac
    19261 gcaactgcaa gcaagttgaa tgacgaactc ctagcaacat ttgacgaaga acaaattttc
    19321 cgtatcgacc attatcttgg taaggaaatg atccaaagca tctttgcagt tcgctttgca
    19381 aacttgattt ttgaaaacgt ttggaacaag gattttatcg acaatgttca aattaccttt
    19441 gcggagcgct tgggtgtaga agaacgtggt ggctactatg accaatccgg tgccctccgt
    19501 gacatggtcc aaaaccacac tctacaactt ctttcgctcc tcgctatgga caaaccagca
    19561 agcttcacaa aagacgagat tcgtgctgaa aagattaagg tctttaaaaa cctctatcat
    19621 ccaactgatg aagaactcaa agaacacttt atccgtgggc aataccgctc tggtaagatt
    19681 gatggcatga aatacatctc ttatcgtagc gaaccaaatg tgaatccaga atcaacaact
    19741 gaaaccttta catctggtgc cttctttgta gacagcgatc gattccgtgg tgttcctttc
    19801 tttttccgta caggtaaacg actgactgaa aaaggaactc atgtcaacat cgtctttaaa
    19861 caaatggatt ctatctttgg agaaccactt gctccaaata ttttgaccat ctatattcaa
    19921 ccaacagaag gcttctctct tagcctaaat gggaagcaag taggagaaga atttaacttg
    19981 gctcctaact cacttgatta tcgtacagac gcgactgcaa ctggtgcttc tccagaacca
    20041 tacgagaaat tgatttatga tgtcctaaat aacaactcaa ccaactttag ccactgggat
    20101 gaagttggtg cgtcatggaa gttgattgat cgtattgaaa agctctgggc tgaaaatggt
    20161 gccccacttc atgactataa agctggaagc atgggacctc aagccagctt tgacctactt
    20221 gaaaaattcg gtgccaaatg gacttggcaa ccagatatcg cctatcgtca agatggtcgt
    20281 ttcgaataaa aaaatcctgc aagtttgtac cttgcaggat ttttgcttct gattagatta
    20341 agccttccaa gagacctttc ataaagtttt ctgagttaaa ctctccaata tcatcgattt
    20401 tttcaccaaa accaatcaat tttacaggaa tattgagttc ttcacgaatg gctagaacca
    20461 cacctcctcg agcagttcca tcaatcttag tcaaaacaat tcccgttaaa ggtgtgattt
    20521 tcgaaaattc tttggcctgt actagggcat tttgacctgt tgatgcatca agtgccaaga
    20581 aggtttcatg tggtgcttct ggcacaacac gtttgataat acgaccaatc ttttccaact
    20641 cagccataag gttatcctta ttttgcagac gaccagcagt atcaatcatg agaatatcga
    20701 taccttcagc cacggcacgt tccataccat caaagaccac gctggctgga tcagcttttt
    20761 caggtccagt tactactgga acatctactc gtcggcccca ttcagctagc tgagctactg
    20821 cacccgtacg gaaggtatct gctgcaacca gcatgacctt cttaccagtt cgtttgtagc
    20881 ggtgggctag ttttccaata gaagttgttt tcccaacacc attcacacca acaaagagca
    20941 taactgtcaa gttatcttgg aagtggatgc tttcatcgta gctaccatcc ttttcataaa
    21001 gctcaaccaa tttctcaatg atgacacgac gaagtgcatc aggtttcttg gcattttcaa
    21061 gcttggcttc gtaacgtagt tcctccgtta agttagaagc gacttggaca ccaacatcac
    21121 tcataatcag cagttcttcc agttcctcga aaaattcttc gtcaacagag cggaagttag
    21181 caaagaaggc gttcaagcga gcaccgaagc ccgtacgagt cttcttgaga ctgcggtcat
    21241 atttttcctg aacagtttct tctgtttgag gcctttctgg ttcaagaact tcagaattat
    21301 tttcttctat agttccttcg tgctcaagct tctcttcctc tggtaattct tctgagtttg
    21361 gtaattcttc tatttcttct tgagaaaccc ctacagctgg ctctgaatcc tgactttctt
    21421 caactgtgtc ttggatttcc tcctcttgga acacagcttg ttcaacaatt tcaacctctg
    21481 cttcttcctg aggaacttca tcagcttctg tgaaggtagg atcaacatct tcagacaaat
    21541 caagattttc cagagcttct tttacaactt cttcgatttt aggttcttct ttttttccga
    21601 atagacggtc aaacaatccc atatcttagt tctcctttag cacatattct tcgatagccc
    21661 aggcgacagc ttcctcatcg ttggtcatcg gcgttactac atttgcggct gcctttactt
    21721 caggaacagc gttttgcata gcaacaccaa gacctgccca ttcaatcata gaaaggtcat
    21781 tggcctcgtc accacaggcc ataacttggc tttggttgat tccaagatgg ctgattagtt
    21841 ttgccaaacc tgttgcttta tgaacattct ttggtgacca ctctagcaac atttcacgtg
    21901 atttaaagat ttcatattgg tcaaacaatt ctggagaaat cttctgaatg gctgcatcca
    21961 agggttcttg agcaaaggcg gtcacgcatt tgttgtaggt catttgatta gacaggtctt
    22021 caaaatcaac tggaacaaaa gtcaaagctg gattgaattt ggcataaaga ctttcttggt
    22081 ccgattgaat ttgataaaca gttccttctg agatagcgtc aagaggcagt gataatttct
    22141 ctgtttcttc atacaagcgt gccacatcat catatgaaaa gactgtctta tcaaggattt
    22201 cacctgtatt tttctgaacc aaaccaccat taaaagtaat ggtatactca tcttcctgac
    22261 cgtcagtccc tagctcatgg agaaagaaat ccatagcttt taagggacga ccagttgtca
    22321 atacgacctt gataccacga tcacgcgcag ctttcaaggt ttccttggta cgatccgtca
    22381 gccttttatc agtagtcagc aaggtcccgt ccaagtccaa tgcgattaat tttatatctg
    22441 ccattataag ccctccatat aagctataac cgactggtcc ttatggtgac caatcacagt
    22501 ctttgctaat tctaaaattt caggtcgtgc attttcagga gctacaggat gtcccacaac
    22561 ctgcatcata tgtaagtcat taagattgtc tccaaaagcc atgacctgat ccattgtgat
    22621 accaagtttt ttaactaatt caacaatggc cactccctta tcgacatagt ccagaacaat
    22681 atcaatagat tcaaagccag ttgtcatagc cttaacacca ggaacgtttt cgtttaccca
    22741 agcctcccca tcttccagcg tttcttctgt gaagttggtt gtaaatttga aaatgtcatc
    22801 tgtgatatct tccaaactcg ctactttttg gatattttca ttataatgct gactcacttt
    22861 caaataggtc tcatcaaccg tatctagaac atatgaaccc ttattacccg tcaagagcag
    22921 tttattgata tctacataag gtgacgtttt cagcttttca aaagttacca gataaaagtc
    22981 acgagacata gtcgcttcat acaagtcctg accttgatac tctaccaaac tgccattttc
    23041 cgcgatgaaa ataatgtcat cacgaacatc agcaaataat ttttccagag acagaaatcc
    23101 ccgacccgaa gccaccgcaa agtaaatccc tttttccttg taggaagcca agagagactt
    23161 gagacgatcc atatcaaagc gtccattccc atctaggaag gttccgtcca tatccgttgc
    23221 tactagttta attgtcatcc ttcaatactt tctaaatctt ttaacttaac tgaaacaatt
    23281 tttgagacac ctgattcttg catggtcact ccatagatag aatcagccgc tgccatggtt
    23341 cccttacggt gggttacgac gatgaactgg ctgtccttgt caaagcggtt gaggtaatcc
    23401 ccaaaacgtt taacattagc ttcatccagc gcagcttcca cctcatccaa gataacaaat
    23461 ggaatagtct tgacacgaat aatggagaag agcaaggcaa gagccgatag agctttttca
    23521 ccaccactca tgaggttaag cgactggatt ttcttacctg gaggttgaac agaaatctcc
    23581 acaccagctg ttaaaaggtc gccctcagtc aatatcaagt ctgcctgacc tccgccaaac
    23641 atctgcttaa aggtcacttt aaaggactca cgaatagctt caaaggttga tttaaagcgt
    23701 tccttaacct catcattcat ctctgtaatg gtttcaagga gcagattttt cgctgacaaa
    23761 atatcatctc gctgactatt tagaaagtcc agacggttgt aaacttcttc gtactggtca
    23821 atagcttcta tattgacagg acccagtgag cgaatagcct tctctaaatc cttaacttct
    23881 tgctctgcca gattgaggtt ttccaattca tgcgcttttt ctagagcttc agtatagcta
    23941 atctggtact ggtctgttaa ttgactttgt agatggcgca agcgttcgct gaccttttct
    24001 ttcttagctt cagcacgtgt ttgcttgcga atccactcct cattctgctg gcgagcctga
    24061 tccaaatgac tagcaatatc atccagctgc ccttcaatat catccaactc aaactgcttg
    24121 cgaatcaaac cttgttggag atttgttttc tgagttttgg cttcttcggc ctgctgattg
    24181 agcaaatccg tatcaacttt ctcaagattg tcaacttttt cttggagcat gcgctggatt
    24241 tcttcttgtt cgatattaag attatccaat tccttgccta aacgctcaat atcagcaact
    24301 tcataacgtt tttgcccttg cagttctgtc ttaagcaaac gagcttgcgc tagctcttcc
    24361 tgcaagtttt gatagcgttc ttggatggca tttttgttag acttaatctc ttcaatctca
    24421 gcttccagat tttgcttgtc actggcgatt gcagcaagac gctcttggca tttttcctta
    24481 tccgcttgcc aatctccctc ggaaagacga tctatttcct cttcttggag tttccaaaga
    24541 gtttccagtt cttcaacttg ctgactggtc tgctgatagg cgagggacaa gccttgctcc
    24601 tgaatacgag cctgctctcc ctgagatttg atggcttcta atctttctgt caatctagct
    24661 agctcatctt gcaagttctt caaactcact tcatctgaac gcaaacttgc ttcttcttca
    24721 gcaatttctt tttgtaattg ctccagttct ggcttgatga aaatactgtt gttctgacga
    24781 ttggctccac ctgcgtaaga accacccgtg cgtaattctg tcccatccaa tgtcaccata
    24841 cgaacctgat aacgaacttg gcgagctgct gcacgcgcat gttctacggt atcaaagata
    24901 gccgtcgtag ctagcaagtt cttgaaaatg gcttccagtc tagtatcaaa agtcaccaac
    24961 tcatctgcca tcccaaggaa acctgggctt acagcgatag catcttggtt ctgactagaa
    25021 atcgtacgcg ccttaatagt ggtcaaagga agaaaggttg cacgaccggc tctgtttcgt
    25081 ttgaggaaat caatggcttt ggttgccgca ttctcatctt ctacaataat gtactgactg
    25141 ctcgctccaa gcgcaatttc tagggcagtt tgataatgca tatcaaaggt cagatgctca
    25201 ctgactgcac caataatccc acctaggcga tctttttctt ggagaacact cttaacacct
    25261 gcataaaagt tactatgatt tctcaggata ttttccaaac tttgagctct ggcctgcttg
    25321 tttttgagat tatccagacg gtcaaagagt tggctttgtt gagcttgata ggaagttttc
    25381 tgctcctctt gctccttggc aatagcttgg tagtcagcca ataatttctg aacctgctcc
    25441 ttggcagttt caagctcttc cttttgctga ctagccttct ctttagctat agctaattgc
    25501 tctttcagct tttctagttg atctgcttgt ttttgagaaa gctgacgact attttccaac
    25561 tcattctcaa tacgggtcaa ctggtttgag acatccgctt cttcttgtaa aagagctaca
    25621 aagcgttcac gtaagagctc aatcatctga tcaggatcgt ctgagaaagc cagcaattca
    25681 gcttctaaac gattgagttt ttgattattt tggactagat ttccctctaa cagagctaaa
    25741 gagctttctt tatcagactt ttctttgctg agtgaatttc tcttatcctc caaagcagcc
    25801 aaacgggctt gtgcctcctg ttgattcaag gccacttgct cggactccag tttcgatagg
    25861 gctaattttc tttctaaatc actaatcaga ctagtcaagt ccatcaaact gccttggtct
    25921 ttggccattt cagcctgtaa atcttggcgt tgctttttaa gagtttgatt ttcttcttct
    25981 aatttttcac gcttttggta ataactcatc aagagttctt gaacctgagt caactcttct
    26041 tctgtcgact ctagttcagc cttattttcc ttgatttgag caaccagaac atctaaataa
    26101 atagccttac gttgtccttc caagtctaaa aacttacggg cattctcagc ttgcttctca
    26161 agaggcttga tttgattatc caactcgtag ataatgtcct ctaagcggtc cagattatcc
    26221 tgagtttgtt gcagtttact ctcagtttct tttctacgag tcttgtattt taaaactcct
    26281 gcagcttctt caaaaatagc tcggcgttcc tcaggcttag aattaaaaat ctcctcaacc
    26341 ttgccttggg aaatgataga gaaggaatct cgtcccaatc cagtatccaa gaagaggtca
    26401 tgaatatcac gcagacggac tttcttgccg tcaatcttgt attcgctatc tccactacga
    26461 tagatatggc gttccaccct gatttcttga cctgcatcct tgataaatcc gtcatgatta
    26521 tccagagtca caactacaga agcataattg agcggtttgc gactttcggt tccagcaaag
    26581 atgacatccg gcatcttgcc cccacggaga ctcttgacac tagactcccc caaagcccaa
    26641 cgcagacttt ctgtaatatt ggactttcca gatccattgg gtccaacaac tgccgtcaca
    26701 ccttggtcaa aaacgacctt ggtcttatca gcaaaagact tgaacccctg aatttcgatt
    26761 tcctttaaat acatgaatcc agccccttct caacggcatt tttggcagct tcctgctctg
    26821 ctaatttctt agaacgacct tggccttgac cgatgctctt accttcaaca agaacttcta
    26881 catcaaagac cttatcgtga gcaggccctg tttcagaaat cacctgataa cgaatagcca
    26941 catcaccatt gacctgaagc aactcttgga gatgggtttt atagtctgta atcatctcaa
    27001 actcgcctgc ttcaacctta ggaatcatga cttgatagat aaattccttg accttggcca
    27061 catccttatc caaaagaagg gcaccaagaa aggcttcaaa ggcatcacca agaatggtgt
    27121 cacgattgcg accaccagat ttttcttccc ctttacccaa cttgataaac tggtcaaact
    27181 ggcaatcacg cgcaaaacca gctaaactct cctcacggac aatcatagca cggagttttg
    27241 ataggtcacc ttcaggcttt ttaggatatt ttttatacag atattctgaa atcaataact
    27301 gtagaacagc gtctcctaaa aattccaagc gttcattgtg tgaaattttt aagaggcggt
    27361 gctcattggc ataactcgta tgagtaaagg cagtttccag taaatttttg tctgtaaatt
    27421 cgattgcaaa atggttcttt agtacagttt gtaattcttt cataccaacc tctttctaac
    27481 tgataacagt cctttttatt atatcaaaaa aagccccctg agtcactcta aaacgggact
    27541 ggaaagcatt tgggaattct ttagacagag attctcagtt ttagcggcaa atttagatca
    27601 gtgtaaagaa aaaagcccta ttaaaggctt tttaggatgt ttacatccac cctgagggaa
    27661 tcgaaccccc atctcaagaa ccggaatctt acgtgatatc cattacacta agggtggaaa
    27721 cttgttttat tataacagaa atttgctcta ataacaagtt ttttagtcaa agcccccgtc
    27781 ttagtgggaa gcatccccat tccagatgga gtttttcacg atcacataat caacgtgttt
    27841 aaggtcagca acctgacgtc cacctgcata agaaatagca ctttgaaggt cttgttccat
    27901 ctcagttaaa gtgtcttgca gatgaccttt agcaggaagc aagatacgtt tgccttccac
    27961 atttttgtaa gcaccttttt gatattgtga ggctgaacca taatattctt tgaactgttc
    28021 accatcgact tcaatcgttt tccctggact ttcaatgtgt cctgcaaaga gggaaccaat
    28081 catgatcatg ctagcaccga agcggataga cttggcaata tcaccgtgag tacgaattcc
    28141 tccatcagcg ataatcggtt tacgcgcagc cttggcacac cagcgtagag cagccaactg
    28201 ccaaccacct gtaccaaaac cagtcttaac cttggtgata caaaccttac caggaccgat
    28261 tccgacctta gtagcatccg caccagcatt ttccaattca cgcacagctt ctggtgttcc
    28321 cacatttcca gcaatgacaa aggtatctgg caattctttc ttgatgtgtt gaatcataga
    28381 aatcacgcta tccgcatgac catgagcaat atcaatagtg atatactcag gagcatcagt
    28441 cttgagctgt ctaacgaaat catactcata gtccttaaca ccgacagaga tagaagcaat
    28501 gagcccttga tcgtgcattc gtttaataaa aggaatgcgt cctgcctcat caaaacggtg
    28561 cataatgtag aagtaaccac ctttagccag ttgctctgct acattttcat ccaaaatcgt
    28621 ctgcatattc gctggcacaa caggtagttt aaaggtgtga tttcctaaag tgacacttgt
    28681 atccgcttct gcacggcttt taatgacaca tttatttgga atcaattgaa tatcttcgta
    28741 atcaaaaatt ggaaattcat ttaacatatc gatgtctcgt ttcttttgta atgacctacc
    28801 tatgctctcg catcactacg tcttttccga cgtttcctta atttattata aaccaaagta
    28861 cagtttttgt caaattattt tatgaattaa aatatatcgt tcgggtttta cttgtgttaa
    28921 aaataaaaga aagaggggaa attattttct ccccacttct tcatcaataa tcgctttaaa
    28981 attttcttct gaattttcca tcattttaca aaatgcacta taggatgagg cattctgagg
    29041 gattcgaata gaccacttct tcaattgagc tccatagcca gctacttttc ctatttcact
    29101 atttactgac tgctccatac taggaaaaat cagtccagcc ttctcagttt ttaaaatata
    29161 agaataggaa atcagctgga ataagtcctc acggttgatt cctttttcag tcaattccag
    29221 ttttttatat tttgcatcta gaacaatctt tcgttctctg tcataaaaat ctggatatac
    29281 ttttcgtttc ccaacaaaaa atactgaaat tccatccgtc ttatccttat ttctgggatg
    29341 tacaaaacct tttggcaaca aggtgtaaac atactcttcc caaagccagg caacatcaaa
    29401 gagaatacca tagatttttt gatcttgata ccctaaaccg tgcttttctt ggtttaggat
    29461 catcagacaa agttcttgta agtttctgta ctcgtgaaag tatgcatgac gtataggttt
    29521 agattgattt ccccgaataa tcttagcacg atcagctagt ttataagagg gcgttacacg
    29581 cacgatttca gatacgtttt cacgactagt tgagagatta tctagtaccc cttgaccaat
    29641 gcttttctga ttcttaatgt attcaatagt gtgacggacc aactgcatga ggggattatc
    29701 ataggtgaac tctctcgttg tgtaggcaat atttcccgtg aaaggaagat ttttcttgag
    29761 atggtttctt acatcaatca ctcccttaac atgactgtcg ttatgagaaa atcgatgata
    29821 ttccttataa agaccttttc gaatagcggc ttgtagatac ttggggaaga gatacatcaa
    29881 aagttgataa agcctctctt cacgagacaa agcaacatct aaactagtga gattgatata
    29941 aagaaccttg tttaagagat aatgcaaaaa atggtcatta ctctcatcag aaaatcgtga
    30001 ggaaatcgtt aatctttcct gaccatatcc aagaaaacca atcacgttcc ctgtcttgat
    30061 tttctgattg actgtttcaa aaatcttttg gtccttatcc aaatcaggag tatgagtcaa
    30121 atcatttgga aaaatgaaaa tacgttcatc ttgggataga ctttccaagg ttctgtctaa
    30181 aaggagattg cttagtttag gatattcttc aacaaatttt tctttaataa tcttgtgttg
    30241 attatcagta atccgcatca tcgttttcat caccttcatt gtcatcagct actgcctgat
    30301 ctttttgctc attatttgtc agttcaaatg cttttttcaa agtttccaaa gtttcaacct
    30361 catcataaga acctcgcaag tagtcttcta ggagaggctt aatataatca gaccagagta
    30421 attcatagtc aaaatctaca tccttcaact taagaaaata acttggtcca atatgataat
    30481 gactgtttaa ttcctgaaca ttttcgatag cagcgttcaa gtttcttaga cgaatttttg
    30541 cttcttctgc atggatattc agctctttat ccaacatgcc aacttgaccc tcggcagtaa
    30601 cttcaacaaa acgaaaacga cgacgcatag caaaatcaaa ggtatccact gaacgatcaa
    30661 tatcattcat agttccgatg atgtaaacat tttcggggat atagaacttt tcatcagttt
    30721 cgtgtagatt tgcatattgg gtagaaacac ttcctttttc accacgatag ccagggtcga
    30781 tagagaaaaa gagttcgcca aaaatcttag aaatctcccc acgattgatt tcatcgatga
    30841 tgaagacgaa tttcttatca gtatcaattt ctgttgggga aacatagtct ttcaaaccaa
    30901 atctctttct caatgtttct aggacagttt ttccaccact tttgtagtat tcttgcttat
    30961 tataattttt atctttatac aactcgtaaa catatttgct aggtagtgac catcctggaa
    31021 caccactatc ataatttact gacaaatttt gtctactatt aacagataag taagatgttt
    31081 ttgttatata ttctttttct tcagcaacat ttatatattc taagtaagaa tcccaagcct
    31141 catcaaaatt atcttgtcct ccaatcaatt gggtttcttt tgctttctga caaaaatctt
    31201 taaaaatacc gtcctgtagc ctaaactcaa tagctccatc cccatttgat actggtctta
    31261 aaccttctac aaaatccgta taatcatatg atgggtgaaa ttgtacaaat ccgatttggt
    31321 cttcgttgcc atccgttaat tctttggcaa tttctttagc aagataagtc tttcctgtgc
    31381 caggagcacc acgaaggata aggtttggag actttaatag agattgagtt aattgatgac
    31441 gaaaattgtt tgatgaatcc attgtactat tgtcttcctt attttccata aaaagcttag
    31501 aatactcaaa aagcatagtt cctaatttcg atggctccaa ctcaggataa gttttggaca
    31561 ccagttcaat tattttatga ttttgcagat aaggtccacc ttgatttgtc tgagaaacaa
    31621 agtggttcca aaattctttc tgactattaa tatttacacc aaagaaagga tctccctcag
    31681 aatagataca aagtaatttt gtcaccatag cagaacgacc aataaattca tttgttgatc
    31741 tttt
//
LOCUS       DAVHIZ010000024        30804 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.024, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000024 DAVHIZ010000000
VERSION     DAVHIZ010000024.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 30804)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 30804)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..30804
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.024"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            338..764
                     /locus_tag="VVO18_001100"
                     /pseudo
     CDS             338..764
                     /locus_tag="VVO18_001100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014295150.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            835..993
                     /locus_tag="VVO18_001101"
     CDS             835..993
                     /locus_tag="VVO18_001101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase domain-containing protein"
                     /protein_id="HEU5586272.1"
                     /translation="MSLLETAKRHQLNSEKYLSYLLECLPNEETLVNKEVLEAYLPWT
                     KVVQEKCK"
     gene            complement(1361..3088)
                     /gene="ezrA"
                     /locus_tag="VVO18_001102"
     CDS             complement(1361..3088)
                     /gene="ezrA"
                     /locus_tag="VVO18_001102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septation ring formation regulator EzrA"
                     /protein_id="HEU5586273.1"
                     /translation="MSNGQLIYLMVAIAVILVLAYVVAIFLRKRNEGRLEALEERKEE
                     LYNLPVNDEVEAVKNMHLIGQSQVAFREWNQKWVDLSLNSFADIENNLFEAEGYNHSF
                     RFLKASHQIDQIESQITLIEEDIAAIRNALADLEKQESKNSGRVLHALDLFEELQHRV
                     AENSEQYGQALDEIEKQLENIQSEFSQFVTLNSSGDPVEAAVILDNTENHILALSHIV
                     DRVPALVTTLSTELPDQLQDLEAGYRKLIDANYHFVETDIEARFHLLYEAFKKNQENI
                     RQLELDNAEYENGQAQEEINALYDIFTREIAAQKVVENLLATLPTYLQHMKENNTLLG
                     EDIARLNKTYLLPETAASHVRRIQTELESFEAAIVEVTSNQEEPTQAYSVLEENLEDL
                     QTQLKDIEDEQISVSERLTQIEKDDINARQKANVYVNRLHTIKRYMEKRNLPGIPQTF
                     LKLFFTASNNTEDLMVELEQKMINIESVTRVLEIATNDMEALETETYNIVQYATLTEQ
                     LLQYSNRYRSFDERIQEAFNEALDIFEKEFDYHASFDKISQALEVAEPGVTNRFVTSY
                     EKTRETIRF"
     gene            complement(3170..5116)
                     /gene="gyrB"
                     /locus_tag="VVO18_001103"
     CDS             complement(3170..5116)
                     /gene="gyrB"
                     /locus_tag="VVO18_001103"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283665.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase (ATP-hydrolyzing) subunit B"
                     /protein_id="HEU5586274.1"
                     /translation="MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLH
                     HLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVF
                     TVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVAD
                     LEVVGDTDRTGTTVHFIPDPKIFTETTTFDFDKLNKRIQELAFLNRGLQISITDKRQG
                     LEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVM
                     SFANNIHTHEGGTHEQGFRTSLTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISV
                     KHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARV
                     AAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQ
                     AILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDAD
                     VDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQ
                     EALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDM
                     LMGDRVEPRREFIEENAVYSTLDV"
     gene            complement(5131..5694)
                     /locus_tag="VVO18_001104"
     CDS             complement(5131..5694)
                     /locus_tag="VVO18_001104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU5586275.1"
                     /translation="MKYHDYIWDLGGTLLDNYETSTAAFVETLALYGITQDHDSVYQA
                     LKVSTPFAIETFAPNLENFLEKYKENEARELEHPILFEGVSDLLEDISNQGGRHFLVS
                     HRNDQVLEILEKTSIAAYFTEVVTSSSGFKRKPNPESMLYLREKYQISSGLVIGDRPI
                     DIEAGQAAGLDTHLFTSIVNLRQVLDI"
     gene            complement(5779..6333)
                     /locus_tag="VVO18_001105"
     CDS             complement(5779..6333)
                     /locus_tag="VVO18_001105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DJ-1/PfpI family protein"
                     /protein_id="HEU5586276.1"
                     /translation="MVKVAVMLAQGFEEIEALTVVDVLRRANITCDMVGFEEQVTGSH
                     AIQVRADHVFDGDLSDYDMIVLPGGMPGSAHLRDNQTLIQELQSFEQEGKKLAAICAA
                     PIALNQAEILKNKRYTCYDGVQEQILDGHYVKETVVVDGQLTTSRGPSTALAFAYELV
                     EQLGGDAESLRTGMLYQDVFGKNQ"
     gene            complement(6344..7567)
                     /locus_tag="VVO18_001106"
     CDS             complement(6344..7567)
                     /locus_tag="VVO18_001106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000830656.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEU5586277.1"
                     /translation="MKRSLDSRVDYSLLLPVFFLLVIGVVAIYIAVSHDYPNNILPIL
                     GQQVAWIALGLVIGFVVMLFNTEFLWKVTPFLYILGLGLMILPIVFYNPSLVASTGAK
                     NWVSINGITLFQPSEFMKISYILMLARVIVQFTKKHKEWRRTVPLDFLLIFWMILFTI
                     PVLVLLALQSDLGTALVFVAIFSGIVLLSGVSWKIIIPVFVTAVTGVAGFLAIFISKD
                     GRAFLHQIGMPTYQINRILAWLNPFEFAQTTTYQQAQGQIAIGSGGLFGQGFNASNLL
                     IPVRESDMIFTVIAEDFGFIGSVLVIALYLMLIYRMLKITLKSNNQFYTYISTGLIMM
                     LLFHIFENIGAVTGLLPLTGIPLPFISQGGSAIISNLIGVGLLLSMSYQTNLAEEKSG
                     KVPFKRKKVVLKQIK"
     gene            complement(7604..10054)
                     /locus_tag="VVO18_001107"
     CDS             complement(7604..10054)
                     /locus_tag="VVO18_001107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional DnaQ family
                     exonuclease/ATP-dependent helicase"
                     /protein_id="HEU5586278.1"
                     /translation="MKTIGNRYVVVDLEATSTGSKAKIIQVGIVVIEDGEIVDHYTTD
                     VNPHEPLDAHIKELTGLTDQRLAQAPDFSQVARKIFDLVEDGIFVAHNVQFDANLLAE
                     NLFFEGYELRNPRVDTVELAQVFFPELEKYSLPILCRELGIPLKHAHTALSDAQATAE
                     LLLFLREKMTQLPKGLLERLLEMADALLYESYLVIEETYRNQSILSSPDLVQVQGLYF
                     KKTAASLEPRKLSQDFSKNISLLNLEVREEQESFAKEVGLLLKDEPVSLIQAPTGIGK
                     TYGYLLPALSQSKERQIVLSVPTKILQNQIMEEEGKRLKEVFHTDIHSLKGPQNYLKL
                     DAFYHSLQKNDENRLFRRFKMQVLVWLTETETGDLDEIGQLYRYQHFLADLRHDGNLS
                     SQSLFVTEDFWKRSQERAETCKLLVTNHAYLVTRLEDNPEFVSDRLLIIDEVQKILLA
                     LENLLQETYDIQSIIDLIDKALVGEENRVQQRILESIRFECLYLIEQFQSGKSRKNIL
                     DSLDNLHQYFSELEVEGFDELVRYFTAEGDYWLEVTETSQKKIQISSTKSCRTLLSSL
                     LPESCQVLGVSATLEISQRVSLADLLGYPEAKFVKIESRGKQEQEVVMVKDFPLVTET
                     SLEVYAREVAALLVEIQAFQQPILVLFTAKDMLLAVSDLLTVSHLAQYKNGDVHQLKK
                     RFEKGEQQILLGAASFWEGVDFSSHPFVIQVVPRLPFQNPQEPLTKKINQELNQEGKN
                     AFYDYQLPMAIIRLKQALGRSMRREYQRSLTLILDRRIIGKRYGKQIVASLAEEATVK
                     TISRSEVDEAIDRFFNEL"
     gene            complement(10254..11183)
                     /locus_tag="VVO18_001108"
     CDS             complement(10254..11183)
                     /locus_tag="VVO18_001108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006154193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEU5586279.1"
                     /translation="MEKIVITATAESIEQVEQLLEAGVDRIYVGEKDFGLRLPTTFSY
                     DQLREIAKLVHDAGKELIVAVNALMHQDMMDRIKPFLDFLEEIKTDYITIGDAGVFYV
                     VNRDGYSFKTIYDASTMVTSSRQINFWGQKAGASEAVLAREIPSAELFKMPEILEIPA
                     EVLVYGASVIHHSKRPLLQNYYNFTHIDDEKTHKRDLFLAEPSDPESHYSIFEDNHGT
                     HIFANNDLDLMIKLTELVEHGFTRWKLEGLYTPGQNFVEIAKLFIQARNLIQEGNFSH
                     DQAFLLDEEVRKLHPKNRFLDTGFYDYDPDMVR"
     gene            11323..11610
                     /locus_tag="VVO18_001109"
     CDS             11323..11610
                     /locus_tag="VVO18_001109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001145225.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3270 domain-containing protein"
                     /protein_id="HEU5586280.1"
                     /translation="MPVRKLQSYEVDYQEELNQQLPHYQAYTPEAQSDANLKEILFFI
                     NIAVFCICIAIFSFIFLALKLSTALAFSAAIGFSLLVLKVQRSIIKRKRRR"
     gene            complement(11644..12978)
                     /gene="ciaH"
                     /locus_tag="VVO18_001110"
     CDS             complement(11644..12978)
                     /gene="ciaH"
                     /locus_tag="VVO18_001110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000491790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system sensor histidine kinase
                     CiaH"
                     /protein_id="HEU5586281.1"
                     /translation="MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLY
                     TSVDDKLHGLSENPQAVIQLAINRATEEIKDLENARADASKVEIKPNVSSNTEVILFD
                     KDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
                     IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQ
                     SFVENASHELRTPLAVLQNRLETLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLN
                     LARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRIHRTIVTDQLLLKQL
                     MTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKA
                     RTRQKGGFGLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK"
     gene            complement(12968..13642)
                     /gene="ciaR"
                     /locus_tag="VVO18_001111"
     CDS             complement(12968..13642)
                     /gene="ciaR"
                     /locus_tag="VVO18_001111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256510.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="two-component system response regulator CiaR"
                     /protein_id="HEU5586282.1"
                     /translation="MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGV
                     YDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKP
                     FYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
                     FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGY
                     LLKDVQ"
     gene            complement(13751..16297)
                     /locus_tag="VVO18_001112"
     CDS             complement(13751..16297)
                     /locus_tag="VVO18_001112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001149089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M1 family metallopeptidase"
                     /protein_id="HEU5586283.1"
                     /translation="MQAVEHFIKQFVPEHYDLFLDLSRETKTFSGKVTITGQAQSDRI
                     SLHQKDLEITSVEVAGQARPFTVDHDNEALHIELAEAGQVELVLAFSGKITDNMTGIY
                     PSYYTVDGVKKEVLSTQFESHFAREAFPCVDEPEAKATFDLSLRFDQAEGELALSNMP
                     EIDVENRKETGIWKFETTPRMSSYLLAFVAGDLQGVTAKTKNGTLVGVYSTKAHPLSN
                     LDFSLDIAVRSIEFYEDYYGVKYPIPQSLHIALPDFSAGAMENWGLVTYREVYLVVDE
                     NSTFASRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVCVDTIEPSWN
                     IFEDFQTGGVPLALERDATDGVQSVHVEVKHPDEINTLFDGAIVYAKGSRLMHMLRRW
                     LGDADFAKGLHAYFEKHQYSNTIGSDLWDALGQASGRDVAAFMDSWLEQPGYPVLTVK
                     VENDVLKISQKQFFIGENEDKNRLWVVPLNSNWKGLPDTLETESIEIPGYAALLAENE
                     GALRLNTENTAHYITDYQGDLLEAVLAELETLDNTSKLQIVQERRLLAEAGHISYADL
                     LPVLDKLAKEESYLVVSAVSQVISALERFIDEGTDAETAFKGLVAKLARHNYDRLGFE
                     AKDGESDEDELVRQLAVSMMIRSNDAEARQVASQIFATHKENLAELPAAIRSQVLINE
                     MKHHETKDLLALYLDTYTHATDAVFKRQLAAALAYSTDADNIQNLITSWKDKFVVKPQ
                     DLSAWYYQFLAHQATQKTAWSWARENWAWIKAALGGDMSFDSFVILPAHVFKTQQRLA
                     EYKEFFEPQLSDLALSRNIGMGIKEIAARVDLISREKAAVEAVVLQYGNA"
     gene            complement(16420..16860)
                     /locus_tag="VVO18_001113"
     CDS             complement(16420..16860)
                     /locus_tag="VVO18_001113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512572.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ASCH domain-containing protein"
                     /protein_id="HEU5586284.1"
                     /translation="MIPQEMWNKYKQINPLIGDEIDAWAFGVEPDLLADLVFKGEKTA
                     TASAYDLYVLEDEPLPQVGTFDIILDSQNQSVCIVEITKVSVELFNQVSAQHAFKEGE
                     GDKSLAYWRQVHEDFFTNCLGEVGLTFTPESKVVLEEFRKVYPL"
     gene            complement(16835..17704)
                     /locus_tag="VVO18_001114"
     CDS             complement(16835..17704)
                     /locus_tag="VVO18_001114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PEP-utilizing enzyme, TIM barrel domain protein"
                     /protein_id="HEU5586285.1"
                     /translation="MRNQLALSGEKILEKIYPQLFHHVGMIRGEYLLRELNQNIILAS
                     CQQFVKDYLETICSLYSDEEVWYRFTELTNTEANCLVGTKEFFDEGHPLFGYRGTRRL
                     LACLDEFQAEAHVVTEVYQTNSNLSVIFPFVNDADQLKQAITVLRQYGFTGKVGTMIE
                     LPSAYFDLSSILETGISKIVVGMNDLTSFVFATMRNSQWHDMESPIMLDMLRDMQDKA
                     RKNKINFAVAGYLNTSFIQKMNQLGIKCIIHYSSIPEIFDLEIDHPDHLKHIKEESKK
                     LQRSTHDTARNVE"
     gene            complement(17746..18474)
                     /locus_tag="VVO18_001115"
     CDS             complement(17746..18474)
                     /locus_tag="VVO18_001115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586286.1"
                     /translation="MELFKTWKKNMVLYGLKSQIGTVYRNNDRTTSFYDVGNFLYLAG
                     ELDSRFWEDFVRKYGLDYKIIISENTNWQDFLHRKVGLNSFTRYSFKDKANFQVEFLN
                     NLVTHLEEGYNIVPIDNHIYNCFSTEEWSQDLQGDFESYQDFVLKGGFGFVILKNNEL
                     IAGISSGLVYRKAVEVEVATRPNEQGNGFAKKLGAAMILESLNRDMFPLWDAHNEASK
                     KVAEFLGYELSEPYEAFELEEILI"
     gene            complement(18482..18961)
                     /locus_tag="VVO18_001116"
     CDS             complement(18482..18961)
                     /locus_tag="VVO18_001116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000403355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU5586287.1"
                     /translation="MEIKKHFGVYAVCLENGKLLCIEKTRGPYQHRYDLPGGSQQLGE
                     GLTETLTREVMEETGFTVRSYSNPRIYDVFVREELKNFMVHHVMALYDVEMNESAPQV
                     TTSEAVSDGANDSLGYIWMDIQEITEENASPLVLKVKSELLGFPELDKTSYMNWKVK"
     gene            complement(18972..19670)
                     /locus_tag="VVO18_001117"
     CDS             complement(18972..19670)
                     /locus_tag="VVO18_001117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151199.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="HEU5586288.1"
                     /translation="MTKRVLITGVSSGIGLAQARLFLEKGYQVYGVDQGEKPLLEGDF
                     HFLQRDLTLDLEPIFDWCPQVDVLCNTAGVLDAYKPLLEQTAQDIQEIFEINYIIPVE
                     LTRYYLTQMLENKKGIIINMCSIASSLAGGGGHAYTSSKHALAGFTKQLALDYAEAGI
                     QVFGIAPGAVKTAMTAADFEPGGLADWVASETPIKRWIEPEEIAELSLFLASGKASAM
                     QGQILTIDGGWSLK"
     gene            complement(19663..19929)
                     /locus_tag="VVO18_001118"
     CDS             complement(19663..19929)
                     /locus_tag="VVO18_001118"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2829 domain-containing protein"
                     /protein_id="HEU5586289.1"
                     /translation="MKNVELKEKNMTFEEILPGLKAKRKYVRTGWGGAENYVQLFDTI
                     EQNGLALEMTPYFLINVSGEGEGFSMWSPTVCDVLATDWVEVHD"
     gene            complement(19995..20921)
                     /locus_tag="VVO18_001119"
     CDS             complement(19995..20921)
                     /locus_tag="VVO18_001119"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001269463.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldo/keto reductase family oxidoreductase"
                     /protein_id="HEU5586290.1"
                     /translation="MRYITLGQDDKELSEIVLGMMRIKDKSVKEVEELVETALSVGIN
                     AFDLADIYGRGRCEELLGLVLKNRPDLREKMWIQSKCGIRIEEFTYFDFSKDYIIKSV
                     DGILQRLKINHLDSLLLHRPDALMESDQVAEAFDLLYKQGKVRDFGVSNQNPMMMELL
                     KKDVKQPLAVNQLQLSAAFTPGFESAFHVNMEDSQAAMRDGSIFEYCQLHDVVIQAWS
                     VLQFGYFKGNFVGNEKFQALNQVLDRLAIKYGVTSSTIAISWILRYPAKMQAVVGTTN
                     PKHLREVSRAANFSLTRKEWYEIYLAAGNNLP"
     gene            complement(20996..21811)
                     /locus_tag="VVO18_001120"
     CDS             complement(20996..21811)
                     /locus_tag="VVO18_001120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586291.1"
                     /translation="MKKMKYYEETSALLHEFSEENQKYFEELWESFNLAGFLYDEDYL
                     REQIYLMMLDFSEAERDGMSAEDYLGKNPKKIMKEILKGAPRSSIKESLLTPILVLAV
                     LRYYQLLSDFSKGPLLTVNLLTFLGQLLIFLIGFGLVATILRRSLVQDSPKMKIGTYI
                     VVGTIVLLVVLGYVGMASFIQEGVFYIPAPWDSLSVFTISLVIGIWNWKEAVFRPFVS
                     MIIAHLVVGSLLRYYEWMGISNVFLTKVIPLAVLFIGIFVLFRGFKKIKWSEV"
     gene            complement(21815..22135)
                     /locus_tag="VVO18_001121"
     CDS             complement(21815..22135)
                     /locus_tag="VVO18_001121"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665424.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEU5586292.1"
                     /translation="MKETQLLKGVLEGCVLDMIGQKERYGYELVQTLREAGFDTIVPG
                     TIYPLLQKLEKNQWIRGDMRPSPDGPDRKYFSLMKEGEERVSVFWQQWDDLSQKVEGI
                     KNGG"
     gene            complement(22342..22422)
                     /locus_tag="VVO18_001122"
                     /pseudo
     CDS             complement(22342..22422)
                     /locus_tag="VVO18_001122"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(22466..24463)
                     /gene="metG"
                     /locus_tag="VVO18_001123"
     CDS             complement(22466..24463)
                     /gene="metG"
                     /locus_tag="VVO18_001123"
                     /EC_number="6.1.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006155678.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine--tRNA ligase"
                     /protein_id="HEU5586293.1"
                     /translation="MSEKNFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRLMGYDV
                     FYLTGLDEHGQKIQQKAEEAGITPQAYVDGMAVGVKELWQLLDISYDKFIRTTDDYHE
                     KVVAQVFERLLAQDDIYLGEYSGWYSVSDEEFFTESQLAEVFRDEAGNVTGGIAPSGH
                     EVEWVSEESYFLRLSKYQDRLVEFFKAHPEFITPDGRLNEMLRNFIEPGLEDLAVSRT
                     TFTWGVPVPSNPKHVVYVWIDALLNYATALGYAQDEHGNFDKFWNGTVFHMVGKDILR
                     FHSIYWPILLMMLDVKLPDRLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRY
                     YLMRNLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVSMINKYFDGQIPAYVEGVT
                     EFDHVLAEVAEQSIADFHTHMEAVDYPRALEAVWTLISRTNKYIDETAPWVLAKDEAL
                     RDQLASVMSHLAASIRVVAHLIEPFMMETSRAVLTQLGLEEVSSLENLSLADFPADVT
                     VVAKGTPIFPRLNMEEEIAYIKEQMEGNKPAVEKEWNPDEVELKLNKDEIKFEDFDKV
                     EIRVAEVKEVSKVEGSDKLLQFRLDAGDGEDRQILSGIAKYYPNEQELVGKKVQIIAN
                     LKPRKMMKKYVSQGMILSAEHDGKLTLLTVDPAVPNGSVIG"
     gene            complement(24587..25846)
                     /locus_tag="VVO18_001124"
     CDS             complement(24587..25846)
                     /locus_tag="VVO18_001124"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586294.1"
                     /translation="MQNLKFAFSSIMAHKMRSLLTMIGIIIGVSSVVVIMALGDSLSR
                     QVNKDMTKSQKNISVFFSPKKSKDGSFTQKQSSFTVSGKEEEIPVEPPKPQESWVQEA
                     AKLKGVDSYYVTNSTNAILTYQDKKVENANLTGGNRTYMDAVKNEIIAGRSLREQDFK
                     EFASVILLDEELSISLFESPQEAINKVVEVNGFSYRVIGVYTSPEAKRSKIYGFGGLP
                     ITTNISLAANFNIDEIASIVFRVNDTSLTPTLGPELARKMTELAGLQQGEYQVADESV
                     VFAEIQQSFSFMTTIISSIAGISLFVGGTGVMNIMLVSVTERTREIGLRKALGATRAN
                     ILIQFLIESMILTLLGGLIGLTIASGLTALAGLLLQGLIEGIEVGVSIPVALFSLAVS
                     ASVGMIFGVLPANKASKLDPIEALRYE"
     gene            complement(25848..26549)
                     /locus_tag="VVO18_001125"
     CDS             complement(25848..26549)
                     /locus_tag="VVO18_001125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586295.1"
                     /translation="MKQLISLKNIFRSYRNGDQELQVLKNINLEVNEGEFVAIMGPSG
                     SGKSTLMNTIGMLDTPTSGEYYLEGQEVAGLGEKQLAKVRNQQIGFVFQQFFLLSKLN
                     ALQNVELPLIYAGVSSSKRRKLAEEYLDKVELTERSHHLPSELSGGQKQRVAIARALV
                     NNPSIILADEPTGALDTKTGNQIMQLLVDLNKEGKTIIMVTHEPEIAAYAKRQIVIRD
                     GVISSDSAQLGKEEN"
     gene            complement(26533..27732)
                     /locus_tag="VVO18_001126"
     CDS             complement(26533..27732)
                     /locus_tag="VVO18_001126"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="efflux RND transporter periplasmic adaptor
                     subunit"
                     /protein_id="HEU5586296.1"
                     /translation="MKKKNGKAKKWQLYAAIGAASVVVLGAGGILLFRQPSQTALKDE
                     PTHLVVAKEGSVASSVLLSGTVTAKNEQYVYFDASKGDLDEILVSVGDKVSEGQALVK
                     YSSSEAQAAYDSASRAVAKADRHINELNQARNEAASAPAPQLPAPVGGEDATVQSPTP
                     VAGNSVASIDAQLGDARDARADAAAQLSKAQSQLDATTVLSTLEGTVVEVNSNVSKSP
                     TGASQVMVHIVSNENLQVKGELSEYNLANLSVGQEVSFTSKVYPDKKWTGKLSYISDY
                     PKNNGEAASPAAGNNTGSKYPYTIDVTGEVGDLKQGFSVNIEVKSKTKAILVPVSSLV
                     MDDSKNYVWIVDEQQKAKKVEVSLGNADAENQEITSGLTNGAKVISNPTSSLEEGKEV
                     KADEATN"
     gene            27997..29343
                     /gene="gor"
                     /locus_tag="VVO18_001127"
     CDS             27997..29343
                     /gene="gor"
                     /locus_tag="VVO18_001127"
                     /EC_number="1.8.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutathione-disulfide reductase"
                     /protein_id="HEU5586297.1"
                     /translation="MREYDIIAIGGGSGGIATMNRAGEHGAKAAVIEEKKLGGTCVNV
                     GCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDFATLRRNREAYIDRARSSYDGSF
                     KRNGVDLIEGHAEFVDSHTVSVNGELIRAKHIVIATGAHPSIPNIPGAELGGSSDDVF
                     AWEELPESIAILGAGYIAVELAGVLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEME
                     RTNLPLHTHKVPVKLEKTTDGITIHFEDGTSHTASQVIWATGRRPNVKGLQLEKAGVT
                     LNERGFIQVDEYQNTVVEGIYALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDY
                     STIPTVVFSHPAIGTVGLTEEQAIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLI
                     TAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGATKADFDATVAIHPTASEEFVTMR"
     gene            complement(29509..30009)
                     /locus_tag="VVO18_001128"
     CDS             complement(29509..30009)
                     /locus_tag="VVO18_001128"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000727305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586298.1"
                     /translation="MKKKIYIALIFVTGVLAIFFFGKQMITKENINKPTVELTIYTLS
                     SSDTEKWNKVRQVETEEAIYFITVKEVSSSEEVFSNIIANGAATGFGVREEEVKKFNN
                     GLGDTIEDSKHNKLIEIEFFTFSDDGAGFVVANFDYGKEELNSQKKDIKELYKKIYES
                     FKEKNK"
     gene            complement(30006..30629)
                     /locus_tag="VVO18_001129"
     CDS             complement(30006..30629)
                     /locus_tag="VVO18_001129"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012679836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5586299.1"
                     /translation="MTIDLLNVSKSFGSKKIFTDLNLIFESGKSYALIGGSGSGKSTL
                     LNIIGRLEKIDSGNVLVDKQDIWKIKERTFFKNTVGYVFQNYSLIDNKTVYDNLSLIT
                     KDKKTITDVLEKVGLSSDYLHQKIYELSGGQAQRVAIARMLMKPRKIILADEPTGALD
                     GEIGKEIIRLLLNETAEDKYVIIATHDPAVYNEVDVIIDMKDIGYKV"
BASE COUNT         9259 a         6673 c         5467 g         9405 t
ORIGIN      
        1 tgctataaac tccaaaaaac ttgattttgg agtagttata aaaactcatt cagataattt
       61 attatttgat tttgatacga ttcctgaaaa tataatagta gttgaccatt ttgaacttac
      121 aatcgaaaaa tggttaagta aaagtcaaca gttactatag tttgcaaatt atttacagaa
      181 agaacaaaaa ttcctaggag attattctgg ctatgtgcat tgtgatatgt tgcggcagta
      241 acttaggact ttagtcctct agttctgcct atgcgatagc agtccaaggt ttaggagcaa
      301 ggcgacgcta agcttggtaa actacgaacc gctagaagct tatcgtcaac tggaagaagc
      361 tgcacttgtt ggatgttggg cgcatgtgag aaggaagttt tttgaagcgc cccccaagca
      421 agcggataaa tcatcgttag gagctaaagg tttagcttat tgtgatcagt tatttgcctt
      481 ggaaagagac tgggaggaca ttgtcagctg atgaacgact acagaaacgt caagaagagc
      541 tccaacccct aatggaagac ttctttgctt ggtgccgtcg tcagtcagtt ttagcaggtt
      601 caaaactagg aagggcaatt gaatacagcc tcaagtataa agaaaccttt aagactattt
      661 tgaaagacgg acatctggtc ctttccaata atctagctga atgcgccatt aaatcattgg
      721 ttatgggacg gagtaaaaga gtccagtgga ctcttttagc ctaagctcag tttaaaaaag
      781 cgagggtggt tgttttctca aagttttgaa ggagctaaag caagagctat tattatgagc
      841 ttattggaaa cagctaaacg tcatcaacta aatagtgaga aatatctatc ctatcttcta
      901 gaatgtcttc caaacgagga aactctcgta aacaaagagg ttttagaggc ctatttaccg
      961 tggactaaag ttgtacaaga aaagtgcaaa taagaaatct ccagattagg aactatccgt
     1021 gagttctcta gtctggagat ttttcaatag acttcgttat tggacagtta ccaagttact
     1081 caaagtacag atttgaagct gcagataaga ctgacgaaat cactttaata ctaaatgaaa
     1141 atcaaaaagc aaactaagag cctcaggctg tacttgagta cggtaaggcg acgctgacgt
     1201 gatttgaaga gattttcgaa gagtataaaa cactgttttg aggtggtgga taaatcggct
     1261 gggcaaaaac tcaatctcag gagaaaatga agtaaatctc cccacaacta tagaaaaaga
     1321 tttgattctg ctcctcacac aataaaatct ttttctttta ttaaaaacga atcgtttcac
     1381 gtgttttctc atatgaggta acaaagcgat tggttacacc aggctctgcc acttccaatg
     1441 cttgagaaat cttgtcaaat gaagcgtgat aatcaaattc tttttcaaaa atatctaaag
     1501 cttcgttaaa tgcttcttga atgcgttcat caaatgagcg atagcggtta gaatattgca
     1561 agagttgctc tgtcaaagtt gcatattgta caatattata agtttccgtt tctaaagctt
     1621 ccatatcatt cgttgcaatt tcaagaactc gggtaacaga ttcaatgtta atcatttttt
     1681 gttctaactc aaccattaaa tcctcggtat tattgcttgc cgtaaagaat aacttcaaga
     1741 aagtttgtgg aatacctggc agattgcgtt tttccatgta tcgcttgata gtatggagac
     1801 gattgacata aacattggcc ttttgacgtg cattaatatc atctttctca atttgtgtca
     1861 ggcgctcact aactgaaatt tgctcatctt caatatcttt tagttgagtt tgtaaatcct
     1921 caagattttc ttcaagaact gaataagctt gggttggttc ttcttgattt gaagttacct
     1981 caacaatagc tgcctcaaaa ctctctaatt ctgtctgaat acgacgaaca tggcttgcag
     2041 ctgtctcagg aagtaaatag gtcttgttca aacgtgcaat atcttctccc aataaagtat
     2101 tattctcttt catatgttga aggtaagttg gaagagttgc aagtagattt tccactactt
     2161 tctgagcagc aatttctcga gtaaaaatat catacaaggc attgatttcc tcttgtgcct
     2221 gtccattctc atattcggca ttatccaatt ccaactgacg aatattctct tggtttttct
     2281 tgaatgcttc ataaagcaag tggaaacgcg cttcaatatc cgtttcaaca aaatgataat
     2341 tagcatcaat tagtttacga taaccggctt ccaaatcctg taattgatct ggcaattctg
     2401 tagaaagcgt cgtaaccaag gctggaacac gatccacaat atgacttaag gccaaaatgt
     2461 gattttctgt attatccaaa atcactgcgg cttccacagg gtcacccgat gaattcaagg
     2521 ttacaaattg tgaaaattca gattggatat tttctaattg tttttcaatt tcatccaagg
     2581 cttgaccata ctgttctgaa ttttcagcaa ctctatgctg aagttcctca aataaatcca
     2641 aagcatgaag aacacgacca ctatttttag attcttgctt ctctaagtct gccaaagcat
     2701 tgcgaattgc cgcaatatct tcttcaatca aagtaatttg actctcaatt tggtcaattt
     2761 gatgactggc cttgagaaaa cgaaatgaat ggttatagcc ttctgcttca aagagattat
     2821 tttcaatatc ggcaaaagag ttgagagata aatcgaccca tttttgattc cattcacgga
     2881 aagccacttg actttgtcca atcaagtgca tattttttac agcttctact tcatcattta
     2941 ctggaagatt gtatagttct tcttttcttt cttctagcgc ctctaatctc ccctcgtttc
     3001 gcttacgtag aaagattgcc actacataag ccagaactaa aatgactgca attgcaacca
     3061 ttaaataaat tagttgtcca ttagacatat caaactcctt ttttacttga aacaatcgta
     3121 acgattatat catatttttt agaccaaggg aactacttct ccctattttt tagacatcaa
     3181 gtgtactata gacagcattt tcttcgataa actcacgacg aggctctact cgatccccca
     3241 tcaacatatc aaagatttta tctgcttctg cagcatcatc tacagaaact ctagccatca
     3301 agcgatgttc gggatccatg gttgtttccc acagctgatg atcgtccatt tcacctagcc
     3361 ccttataacg ctgaatagtc ggtttggtac gaccttcact ataacgggct aaagcttctt
     3421 ggagtttgat ttcttgatct gcacccggct ggatatattc tttaatctcg cttccaacct
     3481 tgacaccata gattggtggt tgggcaatat aaacataacc agcttctagg attggtttca
     3541 tataacgata aatcaaggtt aaaagaaggg tacgaatatg ggctccatcg acatcggcat
     3601 cggtcatcaa aacgagtttt tggtaacggg ctttcgaaac atcaaattct gcgccaaatc
     3661 ctgttcccat ggctgtgaaa agactacgaa tttcttcgtt agctagaatc ttatccatac
     3721 ttgctttttc aacgttcaaa atcttaccgc gaattggaag gatagcctga aactcacggt
     3781 tacgaccaga tttggctgat ccaccagctg agtctccttc gacgatgaag agttctgttt
     3841 cagcagggtt attagaagaa cagtctgcta gtttccctgg aaggttggaa atttccaaac
     3901 cagatttttt acgtgtgact tcacgcgcac gcttggcagc cacacgagcc ttggcagcta
     3961 aaatcccttt ttccacgata cgtttggcaa tctgtggatt ttccatgagg aaatcggaga
     4021 aggcttcact gaagaggcga ttggtaatct tgaccacttc gctatttccc aatttggtct
     4081 tggtttgtcc ttcaaactgt ggatttgggt gtttaactga gataactgca gttaagcctt
     4141 cgcgaacatc ttcccctgtt aaattatctt cattgtcttt cagtaactta ttcttacgag
     4201 cataatcatt gataacacga gtcagtgacg tacggaaacc ttgttcatgc gttccacctt
     4261 catgggtatg aatattattg gcgaaactca tgacattttc atggtaacct gttgtgtact
     4321 gcatggctac ctcaactgtg atatcatcca tctcaccgtc tgtatagatt ggtgtatcaa
     4381 agattacatc cttgttctcg ttgatatatt caacgtaact agcaatccca ccttcataat
     4441 gataatgctt ggtttgttcc aaaccttggc gcttatcagt gatagaaatt tgaagaccgc
     4501 gatttagaaa ggccaactct tgaatccgtt tatttaattt atcaaaatca aaggttgttg
     4561 tttcagtaaa gatttttggg tccggtatga agtgaaccgt tgttccagtt ctatctgtat
     4621 ccccaaccac ctcaaggtct gcaacaacat gaccacgacg gtattcttgg taatgaatct
     4681 taccgttttt atggacatga acgtctaatt gagtggaaag ggcattaact actgacgacc
     4741 ccaccccgtg aagaccacct gaaaccttgt atccaccacc gccgaacttt cctccagcgt
     4801 gaaggactgt aaagacggtc tcaacagcag gacggcctgt tttttcctga atatcgactg
     4861 ggataccacg cccatcatcc acaacagtaa tcgaatcatc tggctcaata aaaacttgaa
     4921 tatggctggc aaatcctgcc aaggcctcgt caattgagtt atcaacaatt tcccagacta
     4981 gatggtgaag accttctttt gaggttgatc caatgtacat ccctggacgc atacgaacag
     5041 cctctaagcc ctctaaaact tgaatttgac tggcatcata atcctgtgcc tgcagatttt
     5101 tgatttcttc tgtcatctta ttcctttttc ttatatgtct aatacttgtc ttaaattcac
     5161 gatactggta aacaagtggg tatcaagtcc tgcagcttga cctgcttcga tatcaatcgg
     5221 ccgatcacca atgacaagac cagagctaat ctgatacttt tctcttaaat aaagcatgga
     5281 ttcgggattt ggctttctct taaagcctga gctagaagtc accacttctg taaaataagc
     5341 tgctatagag gttttttcta aaatttccaa aacctgatca tttcgatgag agaccaaaaa
     5401 atgacggcca ccttgatttg aaatgtcttc caataggtca gaaactcctt caaataaaat
     5461 cgggtgttca agctctctgg cttcattttc cttgtacttt tctaaaaaat tctctaaatt
     5521 gggagcgaat gtctcaatcg caaaaggagt agaaaccttt aaagcttgat agacactgtc
     5581 atggtcttgt gtgataccat acagtgccaa tgtttcaaca aatgcagctg ttgaagtttc
     5641 ataattatcc agtaaagttc cacctaaatc ccagatgtaa tcgtgatatt tcataccctt
     5701 cattatagca tttttttatg aaaaaagcga tgatttccct gagttttcca cataaaaaac
     5761 gagagaataa ctcccgtttt actgattttt accaaagaca tcttgataga gcattcctgt
     5821 tcgtaaactc tctgcgtccc ctcctagttg ctccaccaac tcgtaggcaa aggcaagggc
     5881 tgttgaagga ccccgactgg ttgtcaactg accatctacc actactgttt ccttgacgta
     5941 gtgaccatca aggatttgct cttgaacgcc gtcataacaa gtgtatcgct tatttttcaa
     6001 tatctctgct tgattgaggg caattggtgc cgcacaaatg gctgctagtt tcttcccttc
     6061 ttgctcgaag ctttgcaatt cttgaatcaa ggtctgatta tcacgtaaat gtgcagaacc
     6121 aggcatacct ccaggaagaa caatcatatc atagtctgat aaatctccat caaagacatg
     6181 atctgctctt acttggattg catgcgaacc cgttacttgc tcttcaaaac caaccatatc
     6241 acatgtgata ttggctcgac gcaagacatc tacaactgtc aaggcttcaa tttcttcaaa
     6301 gccctgagct aacataactg ctacttttac catgattttc tccttattta atttgtttta
     6361 atacaacctt tttccgtttg aatgggactt ttccgctctt ttcttcagct agattagtct
     6421 ggtaactcat cgataaaagc aaaccaacac caatcagatt actgataata gctgatcccc
     6481 cttgcgaaat gaaaggcaag ggaatccccg tcaaaggaag tagtccagtc acagcaccga
     6541 tattctcaaa gatgtggaag agcaacatca taatcaaacc tgtggaaata taagtgtaga
     6601 actggttatt tgatttaaga gtaatcttca acatacggta aatcaacatg agatagaggg
     6661 caataaccag gacagagcca ataaagccaa aatcttctgc aataaccgta aaaatcatat
     6721 ctgactctcg aactgggata agcagattcg aagcattaaa tccctgacca aataagccac
     6781 cactcccaat ggcaatctgc ccttgagcct gctggtaagt cgttgtttgg gcaaactcaa
     6841 agggattgag ccaagccaaa atccgattga tttggtaggt cggcattcca atctggtgaa
     6901 gaaaagctcg tccgtccttg ctaataaaga tagctaagaa accagcaact cctgttacag
     6961 cagtcacaaa tactgggata ataattttcc aagaaacccc tgataataaa acgattcctg
     7021 agaaaatggc tacaaaaacc aaagccgtcc ccaagtcact ttgaagtgct aaaagaacta
     7081 ggactggaat ggtaaagaga atcatccaga aaattaacaa aaagtccagc ggaaccgtgc
     7141 gtctccattc cttatgtttc tttgtaaatt ggacaatgac acgagccaac atgaggatat
     7201 aggatatctt cataaattct gacggttgaa atagggtaat tccatttatt gatacccagt
     7261 ttttggcacc cgttgatgca actaagcttg gattataaaa tacaatcggc aagatcataa
     7321 gtcccaagcc taaaatatat agaaaggggg tcaccttcca aagaaattct gtattaaaga
     7381 gcatgaccac aaaaccaatc acaagcccca aggcaatcca ggcgacctgc tgccctaaaa
     7441 tgggcagaat attattggga taatcatgac taacggctat atagatagcc accacaccga
     7501 tgaccagtag aaaaaatact ggcaagagca aactataatc gactctagag tcgagagaac
     7561 gtttcatata tactaacctt atactttcat acaatactat ttatcaaagt tcattaaaaa
     7621 atctatcaat agcctcgtca acttcggatc gagagatggt tttaacagtt gcttcttctg
     7681 ctagagatgc tactatttgt ttgccgtatc gttttccgat gattctccta tccaaaataa
     7741 gagttaagga acgttggtat tcacgtctca tacttcttcc caaagcctgt tttaaacgaa
     7801 taatggccat tggcaattga taatcataaa aggcattttt cccttcttga ttcagttctt
     7861 gattaatctt tttcgtcaag ggttcttgag gattttggaa aggaagcctc ggtacaactt
     7921 gaatcacaaa aggatggctt gaaaaatcaa ctccctccca gaaacttgct gcaccaagca
     7981 agatttgttg ttcacctttt tcaaagcgtt tctttagctg atgaacatcc ccatttttat
     8041 actgggccaa gtggctaact gtaagtaaat ccgatactgc tagaagcatg tctttagcgg
     8101 taaagagaac caaaatcggt tgctggaaag cttgaatttc cactagtaaa gcagctacct
     8161 ctctggcata gacttctaag gaggtttctg ttaccagagg gaaatctttg accataacca
     8221 cttcttgttc ctgttttccc cgagattcaa tcttgacaaa tttggcttca ggatagccta
     8281 aaaggtctgc caaagaaacc ctctgactaa tctcaagagt agccgatact cccaagactt
     8341 ggcaactctc aggaagtaaa gaggacagaa gagtacggca tgattttgta gaagaaatct
     8401 gaattttctt ttgactcgtt tcagttactt caagccagta atcaccttca gctgtaaaat
     8461 agcgaaccag ctcatcaaag ccttctactt ctaattctga aaaatactga tggagattgt
     8521 ccagagaatc taagatattt ttcctagatt taccagactg aaattgttct atcaagtaga
     8581 gacactcaaa gcgaatactt tctagtatcc gttgttgaac cctgttttct tctcctacta
     8641 aagccttatc aattaaatcg ataatagatt gtatatcgta ggtctcttga agcagatttt
     8701 ctagagctaa caaaatcttt tggacttcat caataatcag taaacggtca ctgacaaatt
     8761 caggattatc ttcaagtctg gtcacgagat aggcatgatt agtcactaaa agcttgcaag
     8821 tctctgccct ttcttgacta cgtttccaaa aatcttccgt cacaaataag ctctgggatg
     8881 ataaattccc atcatgacga aggtctgcta gaaaatgttg gtaacggtag agttgcccga
     8941 tttcatccaa atctcctgtc tctgtctcag taagccagac caagacttgc attttaaagc
     9001 gtctaaataa gcgattttca tcatttttct gcaaggaatg ataaaaggca tccaacttca
     9061 gataattttg tggtcccttt aagctatgaa tatctgtatg gaacacttcc ttgaggcgtt
     9121 taccttcttc ttccatgatt tgattttgaa gaatctttgt cggaacacta agaacaattt
     9181 gtcgctcttt ggattgagat aaagcgggta agagatagcc ataggttttc ccaatccctg
     9241 tcggcgcttg aatcagagag acaggttcat ctttcaatag caagccaacc tctttagcaa
     9301 aactttcttg ttcctccctc acttcaaggt tcaacagaga aatattttta gaaaagtctt
     9361 gagatagttt tcgtggctcc agagaagctg ccgttttctt aaaatacaga ccttgaactt
     9421 ggaccaagtc tggagaactc aggatagatt ggttgcgata agtttcctca ataaccaggt
     9481 aggactcata taggagagcg tcagccattt ccagcaagcg ttccaagaga cctttaggaa
     9541 gctgggtcat cttttcccgt aaaaaaagaa gtaattctgc tgtagcttgg gcatctgaaa
     9601 gggctgtgtg tgcgtgttta agaggaattc ctaattctcg acacaaaatc ggcaagctat
     9661 atttttccag ttcagggaaa aagacctggg ccaattcgac cgtatcaaca cgagggtttc
     9721 ttagctcata gccttcaaaa aataaatttt ccgccaagag attagcatca aactgaacat
     9781 tatgggctac aaaaatccca tcctccacca agtcaaatat ttttctggca acttgcgaaa
     9841 aatcaggtgc ttgcgccaga cgttggtctg tcaatcctgt cagttctttg atatgagcat
     9901 ccaagggttc atgtggattg acatccgtcg tatagtgatc gacgatttct ccgtcctcaa
     9961 tcacgacaat tcccacttgg ataattttag ccttactacc tgtgctagtt gcctctaaat
    10021 ccaccacaac atagcgatta ccaatcgttt tcattataaa aaattatacc aaaaaaaggg
    10081 ccatttggca cctgcaaaca taggataatt ttcaaactca agaacactac ttttcttaaa
    10141 aatcccatcg aatagagcat tctagcctgc tgatttttgt aaaatagtga agaaatacga
    10201 aaaattgaga gaagaaatgt ttgcatcttc cttctctcaa cgaatcatgt attttatcta
    10261 accatgtcag gatcgtagtc ataaaatcct gtatcaagga aacggttttt agggtgaagt
    10321 ttacgaactt cttcatccag caagaaggct tgatcatggc taaagttgcc ctcttgaatc
    10381 aagttacgcg cttggataaa gagttttgca atctcaacaa agttctgacc aggagtgtag
    10441 agcccttcta gtttccagcg agtaaagcca tgctccacca attctgttaa tttgatcatc
    10501 aaatcaaggt cattgttggc aaagatatgg gtcccatgat tatcttcaaa aatggaatag
    10561 tggctctctg gatcacttgg ctcagccaag aagaggtcac gtttatgcgt cttttcatca
    10621 tcgatatgtg taaagttata gtagttttgc aagagtggac gtttagaatg atggatgacg
    10681 ctagcaccgt aaaccaaaac ttcagcagga atttccaaaa tctctggcat tttgaaaagt
    10741 tcagctgatg gaatttcacg cgccaaaaca gcctcagatg cgccagcctt ttgtccccag
    10801 aagttaatct gacgactgct agttaccatg gttgaagcat cgtagatggt cttaaatgaa
    10861 taaccatcgc ggttaactac gtaaaagacg cctgcatccc caatcgtaat atagtctgtc
    10921 ttgatttctt ccaagaagtc taagaaaggc ttgatacggt ccatcatatc ttggtgcatg
    10981 agagcattga ccgcaacgat caattcctta ccagcatcat gaaccaactt agcgatttca
    11041 cgtaattggt cataactaaa ggtcgttggc agacgaaggc caaaatcttt ctcaccgaca
    11101 tagatacggt ctacgccagc ttcgagtagt tgttcaactt gttcaatact ttcagcagtt
    11161 gctgtaatga caatcttttc cataagaaaa attataccac atttctccaa aatcatccat
    11221 gctttgaaaa tgaaaaggga ctttattctt tttgtaacct ttctgtaata attctctgcc
    11281 gaaaaaatga taaaataggt atgtactgtt aaggagagaa ttatgcccgt aagaaaatta
    11341 caatcctatg aggtagacta tcaagaagaa ttaaaccagc agcttcctca ttaccaagct
    11401 tatacacctg aagcgcaatc tgatgccaat ctcaaggaaa tcctattttt tattaatatc
    11461 gctgtttttt gtatctgtat tgctatcttt agttttatct ttttagcatt aaaattatca
    11521 actgctcttg ccttttccgc agcaatcgga ttcagcttac ttgttttaaa agttcaacgg
    11581 tctattatca aacgaaaacg tagaagataa atccaaaata tcgccccagt tggagcgata
    11641 tttttatttt ttctttttag atggtgtctg aatggcaatc ttcacttcaa agattgttcc
    11701 cttgggttta ttatctttga cagtaacagt tccttttaga gcatctacaa tttgcttggc
    11761 tagggataat cctaaaccaa aaccaccttt ttgccgggtt ctagctttgt ctactcgata
    11821 aaaacggtca aaaattttct ttttatcttc tgtcgaaata ccgattccat tatcagaaac
    11881 aagtaaataa agattgcgat cggtcgccga gataagaaaa tcaatttcac catcctcctc
    11941 agtatacttg acggcattat cgaaaagaat ggtcatcagt tgtttcagaa gaagctgatc
    12001 tgtgacaatt gttcgatgga tacgattttc aaaacggaag acacgattat tttccgaagc
    12061 aatcatctcg tagtttgtga aagttgtatt aaaaaagcta gttggaactt ctgcaagctc
    12121 cggcttaatc ccatcatctc tccgagctaa gttcagcaag cttgtcgtta aaaaacgcat
    12181 atttcggact tcttccaaac tcgatgcaat gctttcgctc acatccataa tggtagcttc
    12241 tggcttacga aaaagggtct ctaagcgatt ttgcaaaact gcgagtggag ttcgtaactc
    12301 atgactggca ttttccacaa aagactgttg cttctgcata ctctcaagca ggggcctaac
    12361 actgacccta gctagataga gactggcaag taaagacaaa atccagaaac tagccatcac
    12421 gaccacaatc aattgctcat gcttttgact agcctgctcc aactgactgg tattaatcaa
    12481 gacagcagca tacttgatat tggttgaaac cgaactaata ttggtctcca tcaaaatcac
    12541 acgatagatt tcttcctgcc catagctatt aaaaacctga atctggtaga tatgtcctag
    12601 ttctttcttt tctaacttaa tcttatccaa gcccaaaaat cgatttccag aaagaagttg
    12661 agtaaagtct ttatcaaaga gaatgacttc cgtattggaa ctgacattag gttttatttc
    12721 tactttacta gcgtccgccc tagcattttc taaatcttta atctcttctg ttgccctatt
    12781 tatagccagc tgaataactg cttgaggatt ttcactcagt ccatgaagct tatcgtccac
    12841 cgaagtataa agactcgaat gcatgacttg taaaataatc agagtcattg tagaaaaaat
    12901 cagggtgaag acaccgaagt tgcggataaa ataactaaag tcatccgcat accatgtttt
    12961 tttaagttta ctgaacatct tttaaaagat acccaacact acgcaaggtt tgcaaattct
    13021 ctgcaaaagt ggttcccttt aatttcttac ggacttttga aacatagact tcgacaaccg
    13081 aaatcgttgt atcactatca aatccccata gacggtcaaa aatctgcgtc ttaggcaaaa
    13141 tcacattttg attttgaagg aaataaacta gtaaatcgaa ctctttcccc agcaattcga
    13201 caggagtatc ttcaacttta acggtattgg ttgataaatt aaccacgata ttcccataag
    13261 tcaaggtgtt ttcattaaac ttccctgaac gtttgagaag ggcctgaatc cgcattttaa
    13321 gttcttctag gtagaaaggt ttggtcagat aatcatccgc tcccagttca aatccatgtc
    13381 ccttgtcatc caaactttcc ttggcagtca taatcagaac tggtgtcgta attccctttt
    13441 cacgcaattc ttttaagact tggaaaccat ttttttctgg caacatcaaa tccagcaaaa
    13501 tcaagtcata gacaccactc tcagcttcgt agagaccttc ttctccatca aatacctgca
    13561 taacatccgc aaaatcgtct aaaaagtcaa atactgaatt tgacagacct aggtcatcct
    13621 caaccaataa gatttttatc atgagaaact cctccttatt aaaactatta taccaaattt
    13681 gccttaaaaa aaactcaact ctctgcattt tacatgagat agctgagttt tctttttatt
    13741 ttaggcttat ttatgcattt ccgtattgaa gaacaactgc ttcgactgca gctttttcac
    13801 ggctaatcaa gtcaacacgt gctgcaattt ccttgattcc cataccgatg ttacggctaa
    13861 gagcaaggtc agaaagttgc ggctcaaaga actccttgta ttccgccaag cgttgctgag
    13921 tcttaaatac atgagcagga aggataacaa agctatcaaa gctcatatct cctccaaggg
    13981 ctgccttaat ccaagcccag ttttcacgcg cccaagacca agctgttttc tgagttgctt
    14041 gatgagctag gaattggtaa taccaagcag acaagtcctg tggtttgacc acaaatttgt
    14101 ccttccaaga agtaatcaag ttttggatat tatccgcatc tgtactgtat gcaagagctg
    14161 ctgccaactg gcgtttaaag acagcatctg ttgcgtgagt ataagtatca agataaagtg
    14221 ctaacaagtc tttagtctca tgatgtttca tctcattaat cagaacttgt gaacgaatag
    14281 ctgctgggag ttctgcaaga ttctccttgt gtgttgcgaa gatttggcta gcgacttgac
    14341 gagcttctgc atcatttgag cgaatcatca tcgaaacagc cagctgacga accaattcat
    14401 cctcatctga ttctccgtct ttagcttcaa aaccaagacg gtcatagtta tgacgagcca
    14461 atttagcaac cagtcctttg aaggctgttt cagcatccgt tccttcatca ataaagcgct
    14521 caagggctga aatcacttga gaaacagctg aaaccaccag ataagactct tccttagcaa
    14581 gtttatcaag aactggaagc aagtctgcat aagaaatgtg ccctgcctca gccaacaaac
    14641 gacgttcttg aacaatttgc agtttgcttg tgttatcaag tgtctctagc tcagcaagaa
    14701 cagcttctaa caagtctcct tgatagtcgg taatatagtg ggcagtattt tcagtgttga
    14761 gacgaagagc tccttcattt tcagcaagaa gagctgcgta gccagggatt tcgatacttt
    14821 cagtttcgag tgtatcaggc aagcctttcc agttgctatt gaggggcacc acccagagac
    14881 ggttcttgtc ttcgttctca ccgatgaaga attgtttttg tgaaatcttc aagacatcat
    14941 tttcaacttt gacagtaaga actgggtaac caggctgttc caaccaagaa tccatgaagg
    15001 ctgcgacatc acgtcctgac gcttgaccaa gggcatccca aaggtcacta ccaatggtgt
    15061 tgctgtattg gtgtttttca aagtaggcat gcaaaccttt agcaaaatca gcatctccta
    15121 gccaacggcg aagcatgtgc atgagacggc ttcctttggc atagacgata gcgccgtcaa
    15181 agagtgtatt gatttcatct ggatgtttaa cttcgacgtg gacagactga acgccatcag
    15241 tagcgtcacg ttcaagagca agaggtactc cacctgtttg gaaatcttca aagatattcc
    15301 agcttggttc gatggtatcc acacagacgt attccatcat attagcgaaa ctttcattga
    15361 gccaaaggtc atcccaccat ttcatagtca cgaggttccc aaaccattgg tgagccaatt
    15421 catgggccac aacaagggca acttgttgac ggctagcaaa tgtagagttc tcatcgacaa
    15481 ccaagtaaac ttcacggtag gtcacaagac cccagttttc catagcacca gctgagaagt
    15541 caggaagggc gatgtggaga gattgaggaa ttggatactt aactccatag taatcttcgt
    15601 aaaactcgat agagcgaaca gcgatatcca gtgagaaatc aagatttgaa agtggatgtg
    15661 ctttggttga gtagacacct accagggtac catttttagt tttagcggtc accccttgca
    15721 aatcaccagc aacaaaggcc aacaagtaag aagacatgcg aggtgttgtc tcaaacttcc
    15781 agatacctgt ttccttacgg ttttcaacat cgatttctgg catgtttgac aaggccaatt
    15841 caccttctgc ttggtcaaag cgaagagaga ggtcaaaagt tgctttggct tcaggctcat
    15901 ccacacatgg gaaagcttcg cgcgcaaaat ggctctcgaa ctgagtagac aagacctcct
    15961 tcttgactcc atcaactgta taataagaag ggtaaatccc tgtcatgttg tctgtaattt
    16021 taccagaaaa ggcaagaacc aattcaactt gaccagcctc agccaattcg atatgaaggg
    16081 cttcattgtc atggtcaact gtaaatggac gagcttgacc tgcaacttct acagaggtga
    16141 tttccaagtc tttttggtgg agggagatgc ggtcactctg tgcttgacca gtgatggtca
    16201 ctttcccaga aaaagtcttg gtctcacgac tcaaatctaa aaataaatca taatgttcag
    16261 gaacaaattg cttaataaaa tgttcaactg cttgcatagt tttctcctat tctaagttta
    16321 agagctgctg ctcttcttca aacaaactta ttatatcata ttttgcttga gaaaaaagga
    16381 ttggacagcg atttccaaaa ctttcttcct tctaatagtc tacagtgggt agaccttgcg
    16441 aaattcttct aaaacaacct tgctttcagg tgtaaaagtc agccctactt cacccaaaca
    16501 gtttgtgaaa aagtcctcat gaacctggcg ccaataggca agtgatttgt ctccctcacc
    16561 ttccttaaag gcatgttgcg cagaaacttg attgaagagt tcaacagaaa cctttgtaat
    16621 ttcgacaatg cagacagact gattttgact atctaaaatg atatcgaagg tccctacttg
    16681 gggaagtggt tcgtcttcta gtacatagag gtcataggct gatgctgttg ctgtcttttc
    16741 tcctttaaac accaaatccg ctaaaaggtc tggttcaact ccaaaagccc aagcatcgat
    16801 ttcatctccg atcaaaggat tgatttgctt gtatttattc cacatttctt gcggtatcat
    16861 gggtactcct ttgtaatttt ttactttctt cttttatgtg tttaagatga tctggatggt
    16921 caatctctaa atcaaaaatc tctggaatag aactgtagtg gataatgcac ttgataccca
    16981 actgattcat tttttgtatg aaagaagtat tcagatagcc tgctacagca aaattaatct
    17041 tgttctttct tgctttatcc tgcatatctc ttagcatatc taacattatt ggactttcca
    17101 tatcatgcca ttgactgttt ctcatagtcg caaaaacaaa ggaagtcaaa tcattcattc
    17161 caactacaat ctttgaaatg cccgtttcca gtatactaga taagtcaaaa tacgctgacg
    17221 gtaattcaat catcgttccg actttcccag taaagccata ctgacgcaat actgtaatag
    17281 cttgttttaa ttggtcggca tcattgacaa aaggaaagat aacagataga ttggagttgg
    17341 tttgataaac ttctgtaacg acatgtgctt cagcctgaaa ttcatccaaa cacgccagta
    17401 aacgcctagt tcctctatag ccaaacaagg gatgcccttc gtcaaaaaac tctttagtcc
    17461 ccactaaaca attggcttct gtattcgtta attcagtaaa acgataccaa acttcttcat
    17521 ctgagtacag ggagcagata gtctctagat aatcttttac aaattgctga caacttgcta
    17581 atatgatgtt ttgattaagc tctctcaaca aatattcccc acgaatcatg ccgacgtggt
    17641 gaaatagttg aggataaatt ttttcaagaa ttttttcgcc actaagggca agttgatttc
    17701 tcatagccat tcacctcgtc ttaaaagata caatatcata tataattata tcaaaatttc
    17761 ctctagttca aaagcttcat aaggttcaga taactcatat cctaaaaatt ctgctacttt
    17821 tttggaagcc tcattatgag catcccaaag tggaaacata tctctattta aactctctag
    17881 aatcattgca gcaccaagct ttttagcaaa tccatttcct tgttcgtttg gtctagttgc
    17941 aacttccact tcaactgctt tacggtaaac taaccctgag gaaatcccag caatcagttc
    18001 attattttta agaatcacaa agccaaatcc accttttaaa acaaaatcct gataggactc
    18061 aaaatccccc tgtaaatcct gtgaccattc ttccgtagaa aagcagttat aaatatgatt
    18121 atcaataggc acaatattgt aaccttcctc taaatgagta actagattat ttaaaaattc
    18181 aacttgaaaa tttgccttat ctttaaaaga atagcgagta aaagaattta gccccacttt
    18241 tcgatgcaga aaatcttgcc aattagtatt ttctgaaata ataatcttat aatctaaacc
    18301 atattttcta acaaaatctt cccaaaatct ggaatccaac tcccctgcta ggtatagaaa
    18361 attcccaaca tcataaaagc ttgttgtcct atcattgttt cggtagacag ttccaatttg
    18421 agatttaaga ccatagagaa ccatattttt cttccatgtt ttaaatagtt ccattatccc
    18481 tctacttcac cttccaattc atgtaagaag tcttgtccag ttctggaaat cctaataatt
    18541 cagacttaac cttcaagact aatggcgatg cattttcttc tgtaatctct tgaatatcca
    18601 tccaaatata tccaagtgaa tcattcgcac catcagacac agcttccgaa gtcgtaactt
    18661 gaggtgcact ctcattcatt tcaacatcat acaaggccat gacatggtga accataaaat
    18721 tttttaactc ttctctgacg aaaacatcgt agattcgagg attagagtag cttctaacag
    18781 taaatcccgt ctcttccata acttctctag tcagcgtttc cgtcagtcct tcaccaagtt
    18841 gctgactgcc tccaggtaga tcataccgat gttgataagg gcctctcgtt ttttcaatgc
    18901 agagtaactt cccattttct aagcaaacag cgtagactcc aaagtgtttt ttgatttcca
    18961 tccaactcct cctacttcaa agaccagcca ccatctattg tcaagatttg tccttgcatg
    19021 gcgctcgctt ttccacttgc taaaaaaaga ctaagctctg ctatttcctc tggctcaatc
    19081 cagcgcttga ttggggtttc actagccacc cagtcagcca aaccacctgg ttcaaaatcc
    19141 gcagcggtca tagctgtctt gactgctcct ggagcgatac caaagacctg aatcccagct
    19201 tcagcatagt ctagagccaa ctgcttggtg aagccagcca aggcatgctt ggatgaagta
    19261 taggcgtgac cacctccacc tgctaggcta gaagcaatgg aacacatatt gatgatgatt
    19321 ccctttttat tttccagcat ttgtgtcaaa taataccgag tcaactctac tggaataatg
    19381 tagttgattt caaaaatctc ttgaatgtcc tgcgccgttt gttccaacag tggtttgtaa
    19441 gcatccaaaa ctccggcagt attacacaaa acatccacct gagggcacca gtcaaaaata
    19501 ggttccaagt ccaaggtcaa atctctctgt aaaaagtgaa aatcaccctc taagagtggc
    19561 ttttcacctt ggtcaactcc ataaacttga tagcccttct ctaaaaagag gcgagcttga
    19621 gccaatccga tccctgaact cactcctgta atgagtacac gtttagtcat gcacttctac
    19681 ccaatccgtt gccaaaacat cacaaactgt cgggctccac atggaaaaac cttctccttc
    19741 tccagaaacg ttgattagga aataaggtgt catttcaagt gcaagcccat tttgctcgat
    19801 ggtatcaaag agttggacat agttttccgc acctccccaa ccagttcgta catattttct
    19861 cttagccttt aacccaggca ggatctcttc aaatgtcatg tttttctcct ttaattctac
    19921 attcttcatt taattatagc aaaaaaccac tttatacggc tttttgactg tgagttattc
    19981 aaacctgcta ctacttacgg caaattattc cctgcagcaa gataaatttc ataccattct
    20041 tttcttgtta agctaaagtt tgccgctcgg ctaacttctc tcaagtgctt aggatttgtt
    20101 gtacctacga ctgcctgcat ttttgctgga taacgcaata tccaagaaat ggcaatagtt
    20161 gaagaggtta ctccatattt aatagctaaa cgatcaagta cttgatttaa agcttgaaat
    20221 ttctcatttc caacaaagtt ccctttaaaa tacccgaatt gcaagacaga ccatgcttga
    20281 atgaccacat cgtgtaattg gcaatattca aaaatgctgc catctcgcat agctgcttga
    20341 ctatcttcca tattaacatg aaaagctgat tcaaatcctg gagtaaaagc cgcactcaat
    20401 tgtagctgat taacagctaa cggctgcttg acatcttttt taagcaactc catcatcata
    20461 ggattttgat tagaaactcc aaaatctcga actttacctt gtttataaag gagatcaaag
    20521 gcttctgcta cttggtcaga ttccatcaaa gcatctggtc gatgaaggag caagctatct
    20581 agatgattaa tcttcaatct ttgcaaaata ccgtctactg attttataat atagtcctta
    20641 gaaaaatcaa aataggtaaa ttcttcaatg cgaatgccac atttggactg aatccacatc
    20701 ttttctctta aatctggacg attttttagg acaagaccta acagttcttc acaacgacca
    20761 cgaccataaa tatcagccaa gtcgaaggca ttgattccaa cagaaagtgc tgtttctaca
    20821 agctcttcaa cttcttttac agatttatct tttattctca tcattccgag aacaatttct
    20881 gataattctt tgtcatcttg accaagagtt atgtatctca tcaaattttt ctcctttaat
    20941 ttctaacatt cttcccttca ttataacaaa aaaccgcttt gcaacggctt tttgactata
    21001 cttcactcca ttttatcttc ttaaacccac ggaacaagac aaagattcca ataaagagga
    21061 cagctaaagg aataactttt gtaaggaaaa catttgaaat tcccatccac tcataataac
    21121 ggagcagaga acccaccaca agatgggcaa taatcatact gacaaatgga cgaaagaccg
    21181 cttctttcca attccaaata ccgataacta gcgaaatcgt aaagacagac aaactatccc
    21241 agggagccgg aatataaaag actccttctt gtatgaagct tgccattcct acatatccta
    21301 aaacaactag aagaactata gtcccaacaa caatgtaagt gccaattttc attttaggag
    21361 aatcttggac taaacttctt cgtaaaattg tggccacaag tccaaatcca atcagaaaaa
    21421 taagaagttg ccctaaaaat gtgagcaaat tgactgttaa tagaggacct ttagaaaaat
    21481 cacttagtag ttgataataa cgtaataccg ccaggacaag aattggcgtc aaaagggact
    21541 ctttgataga actgcgaggt gctcccttga gaatctcttt cattattttt ttaggattct
    21601 tacctagata atcctctgca ctcatgccat ctcgttctgc ttctgagaaa tctagcatca
    21661 tcaaatagat ctgctctctg agatagtctt catcatagag aaatccagca agattaaaac
    21721 tttcccacaa ctcctcaaaa tacttttgat tctcctcaga aaactcatgt agcaaagcgc
    21781 ttgtttcttc gtaatacttc attttcttca tggtttaacc cccattctta atcccttcta
    21841 ctttttgact caaatcgtcc cattgttgcc aaaagactga gacacgctct tctccttctt
    21901 tcattaatga aaaatacttc cgatctggac catctggcga cgggcgcatg tcgcctctta
    21961 tccattgatt tttttctaac ttttgcaaca aaggataaat agttcctgga acgatagtat
    22021 caaatccagc ctctcgcaaa gtctgaacca actcataacc ataccgctct ttttgaccaa
    22081 tcatatccaa gacacaacct tcaagaacac cttttaatag ctgagtttct ttcatcactt
    22141 ttcccttcta atctattttg taatacctac tagtaacttc acctatagta tatcacttct
    22201 acactagttt gtaaagcata atagttaata ctcttcgaaa atctcttcaa accacgtcag
    22261 cgtcgcccta ccttatgtat ggttactgac ttcgtcagtt tcatctacaa cctcaaaact
    22321 gtgttttgag ctgacttcgt cagtttcatc tacaacctca aaactgtgtt ttgagcaacc
    22381 tgcggctagc ttcctagttt gctctttgat tttcattgag tataaataaa aaaacagaac
    22441 tagcctgaac tagtcctgtc tacttttacc caatcacact tccatttggt acagctggat
    22501 caactgtgag aagggttaat ttgccatcat gttcagctga gagaatcata ccctggctga
    22561 catatttttt catcatttta cgtggtttga ggttagcaat gatttgaact ttcttgccga
    22621 ccaattcttg ttcatttgga tagtattttg caattcctga aagaatctga cgatcttctc
    22681 catcaccagc atccaagcgg aattgaagca acttatctga accttctact ttagacactt
    22741 ctttgacttc tgcgacacgg atttcaacct tgtcaaagtc ttcaaacttg atttcatcct
    22801 tgtttagttt gagctcaact tcgtccggat tccattcttt ttcgactgct ggtttattgc
    22861 cttccatttg ttccttgata taggcgattt cttcttccat atttagacgt ggaaagatag
    22921 gtgttccttt ggcaactaca gtcacatctg ctgggaagtc agccaaactc aagttttcaa
    22981 gactagaaac ttcttccaaa ccaagttgag tcaaaactgc acgactagtt tccatcataa
    23041 atggttcaat caagtgagca actacacgaa tgctggctgc caagtggctc atgacacttg
    23101 ccaattggtc acgaagagct tcatccttgg ccaagaccca tggtgcagtc tcatcgatgt
    23161 atttattggt acgagagatc agagtccaga ctgcttcaag cgcacgtgga tagtcaactg
    23221 cttccatgtg tgtatggaag tctgcgattg attgttctgc aacctcagca agaacatgat
    23281 caaattcagt cacaccttct acataggcag ggatttgtcc atcaaagtac ttattaatca
    23341 tggaaaccgt acggttaagg aggttcccaa ggtcattagc caattcatag ttgatacggc
    23401 cgacatagtc ttcaggagta aaggttccgt ctgaaccaac tggaaggtta cgcatgaggt
    23461 agtaacgaag tggatctagt ccataacgct ctaccaacat ttcagggtaa acgacattcc
    23521 cttttgactt agacattttt ccgtctttca tgacaaacca accatgggca atcaaacgat
    23581 caggtaattt aacatccaac atcataagaa ggattggcca gtagatagag tggaagcgaa
    23641 ggatatcttt tcctaccata tggaagactg ttccattcca gaacttgtca aagttaccat
    23701 gttcgtcttg agcgtagcca agagctgtcg catagttaag aagggcatca atccaaacgt
    23761 agacaacgtg ttttggattt gatgggacag gcactcccca tgtaaaggtt gtacgagata
    23821 ccgccaaatc ttccaaacct ggctcgatga agttgcgtag catttcatta aggcgaccat
    23881 ctggcgtgat aaattcagga tgagctttga aaaattcgac caaacggtct tggtatttgc
    23941 taaggcgaag gaagtatgat tcttcagaaa cccattcaac ctcatgacct gatggagcaa
    24001 taccaccagt cacatttcca gcttcatcac ggaaaacttc tgccagctgg ctttctgtaa
    24061 agaattcttc gtctgatact gaataccaac cagagtattc acccaagtag atatcatctt
    24121 gagcaagtaa gcgttcaaag acttgtgcga caactttttc atggtagtca tcagttgtac
    24181 ggataaattt atcgtatgag atatctagta attgccagag ttctttaact ccaaccgcca
    24241 ttccatcaac ataggcttga ggtgtaatac cagcttcttc cgctttctgc tggattttct
    24301 gaccatgttc atcaagacct gtcagataaa atacatcgta gcccatcagg cgtttgtaac
    24361 gtgctaggac atcacatgcg atagttgtgt aggcagaacc gatatgaagt ttcccagatg
    24421 gatagtaaat cggcgttgta atataaaaat ttttttcaga cataattttt cctttccagg
    24481 caaatgaaac ctgtttttct aacacttcat tatatcacat ttttaatgaa tttcgatagg
    24541 gaaatccata caaaaacaag atagacgagt gtccatcttg ttgatctcat tcataacgaa
    24601 gggcttcaat tggatcaagt ttcgatgcct tgttggctgg caagactcca aaaatcatac
    24661 caacactagc cgaaactgca agactaaata gggcaactgg gattgatact ccaacttcta
    24721 taccttctat taaaccttgc agtaacaaac ctgctaaggc agttaaacca cttgcaattg
    24781 tcaagccaat taagccacct aacaaggtca aaatcatgga ttcaatcaaa aactgaatta
    24841 aaatattggc acgtgttgcg cccaaagcct tacgaagacc aatctcacga gtgcgctctg
    24901 tcaccgaaac cagcatgatg ttcatgacac cagttcctcc aacaaagaga gaaatccctg
    24961 cgatggaact aataatcgtc gtcataaaac taaacgattg ttgaatttct gcaaatacaa
    25021 cggactcatc tgccacctgg tattctccct gttgtaagcc tgcaagctct gtcatttttc
    25081 gtgccagttc tggacccaga gttggggtta aactggtatc attcactcga aagacaatac
    25141 tagctatttc atctatatta aaattcgcag caagggagat attggtagta ataggcaagc
    25201 caccaaaccc atatattttt gaccttttag cctccggact agtataaacc ccaatgaccc
    25261 ggtaactaaa tccattgact tctacaacct tgttaatagc ctcttgagga gattcaaata
    25321 aactaatgga caattcctca tctagcaaaa taacacttgc aaactctttg aaatcttgct
    25381 ctctcagact acgacctgca ataatttcat tcttaacagc gtccatgtaa gttctgtttc
    25441 cacctgtcaa attagcattc tcaacctttt tatcttgata ggtcaagatg gcattcgttg
    25501 aattggttac atagtaacta tccactccct tcagtttagc tgcctcttgg acccaggatt
    25561 cttgcggttt tggcggttca acaggaattt cctcttcctt tccagaaacc gtaaaagatg
    25621 attgtttctg agtaaaagaa ccatctttac tttttttagg agagaaaaag acgctaatat
    25681 ttttctgaga tttagtcata tctttattga cttgacgaga tagggaatca cccaaagcca
    25741 taatcacaac aactgatgaa acaccgataa taatcccaat catagtaagc aaagaacgca
    25801 tcttgtgagc catgatagat gaaaaggcaa atttcagatt ctgcatctta gttttcctcc
    25861 tttcctaact gagcactgtc agacgaaatg accccatccc gaatgacaat ctgacgttta
    25921 gcataggcag caatctcagg ctcatgcgtt accatgataa tggtttttcc ttctttattc
    25981 aaatcaacca ataattgcat aatttggtta cctgttttgg tatccaaggc tcctgtcggt
    26041 tcatccgcta ggataataga aggattgttt accaaggcac gcgcaatggc tacacgttgc
    26101 ttttgaccac cagataattc tgaaggtaaa tggtgactac gttctgtcaa ttcaaccttg
    26161 tctaaatatt cctcagccaa cttgcgacgt tttgaagacg aaactcctgc gtaaatcaag
    26221 ggcaattcta cattttgcag agcattgagc ttcgatagaa gaaagaactg ctgaaagaca
    26281 aaaccgattt gttggttacg gaccttagcc agttgttttt caccaagccc agccacttct
    26341 tgaccttcaa gataatattc tccactggtt ggtgtatcca acatgccaat cgtattcatc
    26401 agagtggact taccagaccc agatggtccc atgatggcta caaattcacc ctcattcact
    26461 tctagattga tatttttgag aacctgcagt tcttggtcac cattacggta gcttctgaag
    26521 atatttttta gactaattag ttgcttcatc agccttcacc tcttttcctt cttccaagga
    26581 agatgttgga ttactgatga ccttagcacc attcgttaaa ccagaagtga tttcttgatt
    26641 ttctgcgtca gcatttccca atgaaacctc aactttttta gccttttgtt gttcatccac
    26701 aatccagaca taatttttac tatcatccat tactagactg ctaacaggaa caagaatagc
    26761 cttagttttg cttttaacct caatgttgac agaaaaaccc tgtttcaaat caccaacctc
    26821 gcctgtcaca tcaatagtat aagggtattt agaacctgta ttattcccgg ctgctggact
    26881 agctgcttca ccattgtttt taggatagtc agaaatatag cttaatttcc cagtccattt
    26941 tttatcagga tacactttag aagtaaagct tacttcttga cctacagaaa ggttggctag
    27001 attgtactca gacaattctc ccttgacttg taaattttca ttgctgacaa tatgaaccat
    27061 aacttggctc gcccctgttg gagatttaga aacattgcta ttgacttcga ctacagttcc
    27121 ctctagggta ctgagaacag ttgttgcatc caattgactt tgagccttgc ttaattgcgc
    27181 tgcagcatct gcacgcgcat cacgggcatc acccaattga gcgtcaatag aagcaacaga
    27241 atttccagcc actggagttg ggctttgcac cgttgcatct tctcctccta ctggcgctgg
    27301 taactgtgga gccggagctg aagcggcttc atttcgtgct tgattgagtt cattgatatg
    27361 acgatctgcc ttagctactg ctcgactagc tgaatcatag gccgcctgcg cttctgaact
    27421 actgtacttg actaaagcct gcccttcgct gaccttatcg cccacagaaa caaggatttc
    27481 atctaaatca cccttactag catcaaaata aacatattgt tcattttttg ctgttactgt
    27541 ccctgacaat aaaacagagg aggccacgct tccttccttg gcaacaacaa gatgagtagg
    27601 ctcatctttt agagcagtct gagaaggttg tctaaagagt aaaatccccc cagcacccaa
    27661 tacaactaca ctcgcagcac cgattgctgc atacagttgc cactttttag ctttaccatt
    27721 ctttttcttc ataatgaaac tccttttctt ttttacaata ctttgctatt ataccaaatt
    27781 tccctccagc aaacaataca gttcaggatt aaacaatcgt tcggaatttt gcttttctat
    27841 tgtactagat atataataca ctatcttgac ttatttggca agcttttttg caattttttg
    27901 tgcgtagcag atttttgcaa tcaaatcaaa aaaagaataa aatataacta tcaaaaaaga
    27961 cgctctacta tttaaaagat tacaaaggag ttttcaatga gagaatatga tatcattgct
    28021 atcggtggag gtagcggagg aatcgctacc atgaaccgtg ctggtgaaca tggagccaaa
    28081 gcagccgtta ttgaggaaaa gaaattaggt ggaacctgtg tcaacgtcgg ttgtgttcct
    28141 aaaaaaatca tgtggtacgg ggcgcaaatc gctgagactt tccatcaatt tggagaagac
    28201 tacggcttta agactactga tcttaacttt gactttgcaa ccctacgtcg caatcgtgaa
    28261 gcctacattg atcgcgctcg ttcttcttat gatggtagtt ttaaacgcaa cggtgtagac
    28321 ttgattgaag gtcatgctga atttgtagat tctcatactg taagcgtaaa tggtgaactg
    28381 attcgtgcta aacatatcgt gattgctaca ggtgcccatc caagtattcc taatattcct
    28441 ggtgctgagc taggtggctc ttctgatgat gtatttgcct gggaagaact tccagagtca
    28501 attgccattc taggcgctgg ttatatcgcc gttgaattag ctggcgtact ccacactttt
    28561 ggtgtcaaga cagatctctt tgttcgccgc gatcgtcctt tacgtggttt tgattcctac
    28621 atcgttgaag gtttggtcaa ggaaatggaa agaacaaact taccacttca cactcacaaa
    28681 gtccctgtca agttagaaaa aactactgac ggcattacca ttcatttcga agatggtact
    28741 agtcacacag ctagccaagt tatctgggct acaggtcgcc gtccaaacgt taagggcttg
    28801 caacttgaaa aagctggagt gactctgaac gaacgtggct ttatccaagt ggatgaatac
    28861 caaaatactg ttgttgaggg aatctatgct ctaggtgatg taacgggcga gaaagaactg
    28921 actccagttg caatcaaggc cggacgtacc ctatctgaac gtctctttaa cggaaaaact
    28981 actgcaaaaa tggattactc aactattcca actgttgtct tttcacaccc tgctatcgga
    29041 actgttggtt tgacagaaga gcaagctatt aaagaatacg gtcaagacca aatcaaggtt
    29101 tataaatcaa gctttgcatc tatgtactct gcttgcactc gcaaccgtca agaatcccgt
    29161 ttcaaactca taacagctgg ttcagaggaa aaagttgtcg gacttcatgg aattggctac
    29221 ggcgttgatg aaatgattca aggatttgcc gttgctatca aaatgggagc aaccaaggct
    29281 gactttgatg caactgtggc aattcaccca actgcatctg aagaatttgt aaccatgcgt
    29341 taatcgaaac aaaagaagca aagcaaaaaa cacttctaaa tatcaaaaag cgagtatttc
    29401 cgtagttgga gatactcgtt ttcttatgtt ttattttata gtatgttgaa gtaagatatg
    29461 caaaaatcaa ttaacaaacc atagcaaaat acaaggatta taatacaatc atttattctt
    29521 ttctttaaaa gattcatata tttttttata taattctttt atatcttttt tctgagaatt
    29581 caactcttct ttaccgtagt caaagtttgc taccacaaat cccgcgccat catcagaaaa
    29641 agtaaaaaat tctatttcaa ttagtttatt atgcttagag tcctctatgg tgtctcctaa
    29701 accattattg aatttcttca cttcttcttc acgaactccg aaccccgtag cagctccatt
    29761 tgcaatgatg tttgaaaata cttcttctga agatgatact tctttcacag ttatgaagta
    29821 tatagcttct tccgtttcta cttgtctcac tttattccat ttttctgtat cactagaaga
    29881 aagcgtatag attgttaact ctaccgttgg cttattgata ttttcttttg taatcatttg
    29941 ttttccaaaa aagaaaatgg cgagtacccc agttacaaag atcaaagcaa tataaatttt
    30001 ctttttcata ccttataccc tatatctttc atgtcaatta tcacatcaac ttcgttatag
    30061 acagctggat catgtgtcgc tataatgaca tatttatctt cagctgtttc attcaatagt
    30121 aaacgaataa tttcttttcc aatctcacca tctaaagctc ctgtaggttc atctgctaag
    30181 ataattttac gtggtttcat taacattctg gcaatagcta cacgttgagc ctgccctcca
    30241 gacaattcat atattttttg gtgtaaatag tcacttgaca gtcctacttt ttcaagtacg
    30301 tcagttattg tttttttgtc tttagtgata aggctcagat tatcatacac tgttttgtta
    30361 tctattaaag aataattctg aaatacatat ccaacagtat ttttaaaaaa agttctttct
    30421 tttatcttcc aaatatcttg tttatcaact aaaacattcc cactgtcaat tttttctaat
    30481 cttcctataa tattaagaag ggtactttta ccggagccag aacctccaat caatgcatag
    30541 ctttttccag attcaaatat taaatttaag tctgtaaaga tcttctttga gccgaaactt
    30601 tttgaaacgt tcaaaaggtc aattgtcatg attcatctcc ttttaaaatt ttagtgtagc
    30661 tttcagataa ttttctaaaa ctcattatga ttgacaacat caaaactagc agagaagccg
    30721 ctccaatata tagcaactct atttgccctg tcataagaaa tgtaaataga ataaccattg
    30781 taatagtcat cataaaatat ttga
//
LOCUS       DAVHIZ010000025        27345 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.025, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000025 DAVHIZ010000000
VERSION     DAVHIZ010000025.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 27345)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27345)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..27345
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.025"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            333..1496
                     /locus_tag="VVO18_001130"
     CDS             333..1496
                     /locus_tag="VVO18_001130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent rRNA methyltransferase"
                     /protein_id="HEU5586300.1"
                     /translation="MNRIRVSKRVEKKLAKGLVLLEASDLENVNLKDQEVEVQGQEGN
                     FLGTAYLSQQNKGLGWFVSKDKVAFNQAFFETLFRKAKEKRSAYYQDDLTTTYRLFNQ
                     EGDGFGGLTVDLYGDYAVFSWYNSYVYQIRQTISEAFRQVFPEVLGAYEKIRFKGLDY
                     ESAHVYGQEAPDFFTVLENGVLYQVFMNDGLMTGIFLDQHEVRGSLVDGLAMGKSLLN
                     MFSYTAAFSVAAAMGGASQTTSVDLAKRSRELSQAHFQANGLSTDEHRFIVMDVFEYF
                     KYAKRKNLTYDVIVLDPPSFARNKKQTFSVAKDYHKLISQSLEILNPGGIIIASTNAA
                     NVSRQKFTEQIDKGFAGRSYQILNKYGLPADFAYNKKDESSNYLKVISMKVSK"
     gene            1493..2170
                     /locus_tag="VVO18_001131"
     CDS             1493..2170
                     /locus_tag="VVO18_001131"
                     /EC_number="4.2.1.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="HEU5586301.1"
                     /translation="MKLIVSVMPRSLEEAQALDATRYLDADIIEWRADYLPKEAILQV
                     APAIFEKFAGRELVFTLRTRSEGGEIDLSPEEYIHLIKEVAQLYQPDYIDFEYYSYKD
                     VFEEMLDFPNLVLSYHNFQETPENMMEILSELTILNPKLVKVAVMAHTEQDVLDLMNY
                     TRGFKTLNPEQEYVTISMGKVGKVSRITADVTGSSWSFASLDEVSAPGQISLASMKKI
                     REILDEA"
     gene            2160..3014
                     /locus_tag="VVO18_001132"
     CDS             2160..3014
                     /locus_tag="VVO18_001132"
                     /EC_number="1.1.1.25"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate dehydrogenase"
                     /protein_id="HEU5586302.1"
                     /translation="MKLDGYTRLTAVVANPIKHSISPFIHNRAFEATATNGAYVAWEI
                     EASDLAETVANIRRYQMFGINLSMPYKEQVIPYLDKLSDEARLIGAVNTVVNENGNLI
                     GYNTDGKGFFKCLPSFTISGKKMTLLGAGGAAKSILAQAILDGVSQISVFVRSVSMEK
                     TRPYLDKLQEQTGFKVDLCALEYVSELQARIAESDLLVNATSVGMDGQSSPVPENIVL
                     PETLLVADIIYQPFETPFLKWARSQGNPAVNGLGMLLYQAAEAFQLWTGKEMPTEEIW
                     QSLTEKYQ"
     gene            3033..4100
                     /locus_tag="VVO18_001133"
     CDS             3033..4100
                     /locus_tag="VVO18_001133"
                     /EC_number="4.2.3.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002308136.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-dehydroquinate synthase"
                     /protein_id="HEU5586303.1"
                     /translation="MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNH
                     VASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVAL
                     GGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQP
                     DGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLI
                     EHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISK
                     IAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVP
                     ELGSATIHPVSLEEMKDYLVK"
     gene            4110..5276
                     /gene="aroC"
                     /locus_tag="VVO18_001134"
     CDS             4110..5276
                     /gene="aroC"
                     /locus_tag="VVO18_001134"
                     /EC_number="4.2.3.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate synthase"
                     /protein_id="HEU5586304.1"
                     /translation="MRYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYG
                     RGGRMKIENDQVVFTSGVRHGKTTGAPITMDVINKDHQKWLDIMSAEDIEDRLKSKRK
                     ITHPRPGHADLVGGIKYRFDDLRNSLERSSARETTMRVAVGAVAKRLLAELDMEIANH
                     VVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQIKRDGDTIGGVV
                     ETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGVEFGLGFEAGYRKGSQVMDEI
                     LWSKEDGYTRRTNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKAT
                     VERSDPTALPAAGMVMEAVVATVLAQEILEKFSSDNLEELKEAVAKHRDYTKNY"
     gene            5286..6389
                     /locus_tag="VVO18_001135"
     CDS             5286..6389
                     /locus_tag="VVO18_001135"
                     /EC_number="1.3.1.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydrogenase"
                     /protein_id="HEU5586305.1"
                     /translation="MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIAL
                     KEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKST
                     IVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKE
                     MKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAG
                     GFRDMTRIAESEPGMWTSILLSNSETILDRIEDFKERLEVIGQAISKGDEEQIWNFFN
                     QAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENRED
                     IHGILQISFKNAQDLERAEHLITENTDYTVVIK"
     gene            6400..6738
                     /locus_tag="VVO18_001136"
     CDS             6400..6738
                     /locus_tag="VVO18_001136"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000065990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlbF/YmcA family competence regulator"
                     /protein_id="HEU5586306.1"
                     /translation="MSNIYDSANELSRGLRGLPEYKTVKAAKDAIAADAEASKIFTEY
                     LAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKI
                     VFEPVSELLK"
     gene            6830..8113
                     /gene="aroA"
                     /locus_tag="VVO18_001137"
     CDS             6830..8113
                     /gene="aroA"
                     /locus_tag="VVO18_001137"
                     /EC_number="2.5.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="HEU5586307.1"
                     /translation="MKLKTNIRHLHGSIRVPGDKSISHRSIIFGSLAEGETKVYDILR
                     GEDVLSTMQVFRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNMGNSGTSIRLISGVL
                     AGADFEVEMFGDDSLSKRPMDRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHY
                     ELPIASAQVKSALMFAALQAKGASVIIEKECTRNHTEDMLKQFGGHLSVDGKKIIVQG
                     PQKLTGQKVVVPGDISSAAFWLVAGLIVPNSRLVLQNVGINETRTGIIDVIRAMGGKL
                     EITEIDPVAKSATLIVESSDLKGTEICGALIPRLIDELPIIALLATQAQGVTVIKDAE
                     ELKVKETDRIQVVADALNSMGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAI
                     AALLVADGEVELDRAEAINTSYPSFFDDLESLIHG"
     gene            8106..8582
                     /locus_tag="VVO18_001138"
     CDS             8106..8582
                     /locus_tag="VVO18_001138"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="shikimate kinase"
                     /protein_id="HEU5586308.1"
                     /translation="MAKVLLGFMGAGKSTIARGLDTNYLDMDALIEKRLGMSIANFFA
                     EKGEAAFRHVESEVLADLLQTDQVVSTGGGVVISQRNRDLLKTNTDNIYLKADFETLY
                     LRIAADKDNQRPLFLNNSKEELVAIFQERQAWYEEVASRVLDVTKLSPEEIIEELR"
     gene            8579..9427
                     /gene="pheA"
                     /locus_tag="VVO18_001139"
     CDS             8579..9427
                     /gene="pheA"
                     /locus_tag="VVO18_001139"
                     /EC_number="4.2.1.51"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEU5586309.1"
                     /translation="MKIAYLGPKGSFSHHVVQTAFPHEELQAFANITDVIKAYEQGLV
                     DYSVVPVENSIEGSVHETLDYLFHQAHIQAVAEIVQPIHQQLMVVPGHTKIEKIFSHP
                     QALAQGKKFIDEQYPEAQIEVTASTAYAARFISEHPDQPFAAIAPRSSTEEYGLELIA
                     EDIQEMEANLTRFWVLGAEKPSIPLQAQTEKMSLALTLPDNLPGALYKALSTFAWRGI
                     DLTKIESRPLKTALGEYFFIIDVDYTDKDLVHFAQKELEAIGIQYKILGAYPIYPISD
                     HGKERR"
     gene            9424..10698
                     /gene="psr"
                     /locus_tag="VVO18_001140"
     CDS             9424..10698
                     /gene="psr"
                     /locus_tag="VVO18_001140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyisoprenyl-teichoic acid--peptidoglycan
                     teichoic acid transferase Psr"
                     /protein_id="HEU5586310.1"
                     /translation="MSKENPLSHHEQLRYDYLLKNIHYLNEREKNEFAYLQEKLTLAR
                     GNSSSSLEQEREEQVDLPSYANRSRSQSKSQALSFPPKKKRRKLRLKRIFMVIFSLLV
                     CVALAMVFMFLRGYQDASAKKTADARAAQVEVFNGQDTRDGVNILIMGTDGRIGQNSV
                     ETRTDSIMVLNVGGSDKKMKLVSFMRDNLVYIDGYSQVINGRKQTDNKLNVAYELGEQ
                     EGQKGAEMVRQVLKDNFDLDIKYYALVDFQAFATAIDTLFPDGVTIDAQFSTLNGRPL
                     TEATVGDDLYATETESPTQTIKVGKQQMNGSTLLNYARFRDDDEADYGRTKRQQQVLT
                     AILEQIKDPTKLFTGSEALGKVFAMTSTNVPYTFLLTNGLSVLDGAKNGIEKLTIPEL
                     GDWVDAYDVYGGLGLLVDQNKYQTKLAQMGLR"
     gene            10977..11822
                     /locus_tag="VVO18_001141"
     CDS             10977..11822
                     /locus_tag="VVO18_001141"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001061982.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU5586311.1"
                     /translation="MNNMTDLKAIQARSLEMAEYFVAFCKEHDLLCYLCGGGAIGALR
                     NKGFIPWDDDLDFFMPRKDYEKLAELWPRYADERYFLSKSHKNFVDRNLFITIRDKET
                     TCIKPYQQDLDLPHGLALDILPLDYYPKNPAERKKQVRWALIYSLFCAQTIPEKHGAL
                     MKWGSRILLGLTPKSLRYRIWKKAEKEMTKYDLADCDGITELCSGPGYMRNKYPITSF
                     EDNLFLPFEGTEMPIPIGYDVYLRTAFGDYMTPPPADKQVPHHDTVIADMDKSYTKYK
                     GEYGG"
     gene            11812..12915
                     /locus_tag="VVO18_001142"
     CDS             11812..12915
                     /locus_tag="VVO18_001142"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase"
                     /protein_id="HEU5586312.1"
                     /translation="MVAKKKILFFMWSFSLGGGAEKILSTIVSNLDPEKYDIDILEME
                     HFDKGYESVPKHVRILKSLQDYRQTRWLRAFLWRMRIYFPRLTRRLLVKDDYDVEVSF
                     TIMNPPLLFSKRREVKKISWIHGSIEELLKDSSKRESHRSQLDAANTIVGISKKTRNS
                     IKEVYPDYASKLQTIYNGYDFQTILEKSQEKIDIEIAPQSICTIGRIEENKGSDRVVE
                     VIRLLHQEGKNYHLYFIGAGDMEEELKKRVKEYGIEDYVHFLGYQKNPYQYLSQTKVL
                     LSMSKQEGFPGVYVEALSLGLPFISTDVGGAEELSQEGRFGQIIESNQEAAQAITNYM
                     TSASNFDVDEASQFIQQFTITKQIEQVEKLLEE"
     gene            12917..13903
                     /locus_tag="VVO18_001143"
     CDS             12917..13903
                     /locus_tag="VVO18_001143"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000446977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5586313.1"
                     /translation="METALISVIVPVYNVAQYLEKSIASIQKQTYQNLEIILVDDGAT
                     DESGRLCDSIAEQDDRVSVLHKKNEGLSQARNDGMKQAHGDYLIFIDSDDYIHPEMIQ
                     SLYEQLVQEDADVSSCGVMNVYANDESPQSANQDDYFVCDSQTFLKEYLIGEKIPGTI
                     CNKLIKRQIATALSFPKGLIYEDAYYHFDLIKLAKKYVVNTKPYYYYFHRGDSITTKP
                     YAEKDLAYIDIYQKFYNEVVKNYPDLKEVAFFRLAYAHFFILDKMLLDDQYKQFEAYS
                     QIHRFLKGHAFAISRNPIFRKGRRISALALFINISLYRFLLLKNIEKSKKLH"
     gene            13919..15352
                     /locus_tag="VVO18_001144"
     CDS             13919..15352
                     /locus_tag="VVO18_001144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen polysaccharide polymerase Wzy family
                     protein"
                     /protein_id="HEU5586314.1"
                     /translation="MIDGKRLLFSLTIVSYALTLVSGIVYLFNNNNVSLLSTLLFLLV
                     SSLIACWNDIKYYLIHFIFYLTIFVFLVSRPTIDYFRDGALDTYHPIAYRFAFIVVMV
                     SILGLTTGGILARYFIARKKIKVANIGNSLKEVYIKRLRFVSLVVFLLTYPFYFIRLF
                     ERLLYRLQTSYYAYYANFESKLPYFTYILSTFTVYAMCMYLATKPKKLQATAVLVSFI
                     AANTIHLAIGTRNPFILSILFAFVYYFMREQTEKGKWIGFKEKLAIFVGSPILMLAMG
                     VLNYVRDNVQVSHTGFWDILLDFIYKQGTSFGVLARGFLFNSSLPYRDFRNFTFGPVL
                     DYFARGSLGAIFGGKAFEHTTNSVELAIDSNSYAHNLSYLVLNKEYLKGHGIGSSYIM
                     ELYTDYGMIGVFLLSFLLGVLFIAMLQVAYRSRTILFALSLLILNNLFFMPRSSFSES
                     FFNLFTMQFWGIVLVIIFVAKMLTKEN"
     gene            15381..16415
                     /locus_tag="VVO18_001145"
     CDS             15381..16415
                     /locus_tag="VVO18_001145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prephenate dehydratase"
                     /protein_id="HEU5586315.1"
                     /translation="MFEHYSVADLFANLYKKRKANILALIALFALIAVPFTIKAVRNK
                     NTVKDTTSYSTYLIYKITPPEDSAKTILNHQIGGYSDFYGKLIDGNLNGAYLFNDVEP
                     SELKKIASELDTTETTLKNSTNDYWWKKLTVYYMIDDAGVGVKILTSSKDANDLLEKK
                     IDGLIEKFKHAYANVKIEKLETINSKELNANGETALGLNVKNLILRLVVIGVVCVILV
                     VMGNVLVYLFNPTINRVGDFSQYQIDFVTEITTIANLADVLSYKNTGQELTIVSSNKA
                     ILDKLKQSQEALKGMHFVDLQDVSSLLERDTVLLVEEYGVTRYKKFEQSLQILRNLNR
                     SILGVATFKL"
     gene            16615..17352
                     /gene="mecA"
                     /locus_tag="VVO18_001146"
     CDS             16615..17352
                     /gene="mecA"
                     /locus_tag="VVO18_001146"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782680.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adaptor protein MecA"
                     /protein_id="HEU5586316.1"
                     /translation="MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAI
                     LDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKIDQNLDFEDLSDLPDMEELAQMS
                     PDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
                     KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDS
                     DISRSVLQEYGQVLMSHDAVLNLQKIG"
     gene            17503..18789
                     /locus_tag="VVO18_001147"
     CDS             17503..18789
                     /locus_tag="VVO18_001147"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine dehydrogenase"
                     /protein_id="HEU5586317.1"
                     /translation="MTVKIALLGFGTVASGVPFLLKENGGKINQSAHSDIKVAKVLVK
                     DEDEKNRLLAAGNDFNFVTNVDDILSDHDITIVVELMGRIEPAKTFITRALEAGKHVV
                     TANKDLLAVHGAELLEIAQANKVALYYEAAVAGGIPILRTLANSLASDKITRVLGVVN
                     GTSNFMVTKMVEEGWSYDDALAEAQRLGFAESDPTNDVDGIDAAYKMVILSQFAFGMK
                     IAFDDVAHKGIRNITPEDVAVAQELGYVVKLVGSIEETSSGIAAEVTPTFLPKAHPLA
                     SVNGVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADIVRIVRRLNDGTIGKDFNEY
                     SRDLVLANPEDVKANYYFSILALDSKGQVLKLAEIFNAQDISFKQILQDGKEGDKARV
                     VIITHKINKAQLENVSAELKKVSEFDLLNTFKVLGE"
     gene            18791..19660
                     /locus_tag="VVO18_001148"
     CDS             18791..19660
                     /locus_tag="VVO18_001148"
                     /EC_number="2.7.1.39"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000692406.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="homoserine kinase"
                     /protein_id="HEU5586318.1"
                     /translation="MKIIVPATSANIGPGFDSVGVAVTKYLQIEVCEERDEWLIEHQI
                     GKWIPHDERNLLLKIALQIVPDLQPRRLKMTSDVPLARGLGSSSSVIVAGIELANQLG
                     QLNLSDHEKLQLATKIEGHPDNVAPAIYGNLVIASSVEGQVSAIVADFPECDFLAYIP
                     NYELRTRDSRSVLPKKLSYKEAVAASSIANVAVAALLAGDMVTAGQAIEGDLFHERYR
                     QDLVREFAMIKQVTKENGAYATYLSGAGPTVMVLASHDKMPIIKAELEKQPFKGKLHD
                     LRVDTQGVRVEAK"
     gene            19730..19810
                     /locus_tag="VVO18_001149"
                     /pseudo
     CDS             19730..19810
                     /locus_tag="VVO18_001149"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            20001..20939
                     /gene="msrB"
                     /locus_tag="VVO18_001150"
     CDS             20001..20939
                     /gene="msrB"
                     /locus_tag="VVO18_001150"
                     /EC_number="1.8.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="HEU5586319.1"
                     /translation="MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLL
                     KETDHAETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDEAD
                     LPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYCHIDVTDADKP
                     LIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAYDQTFEEGIYVDITTGEPL
                     FFAKDKFASGCGWPSFSRPISKELIHYYKDLSHGMERIEVRSRSGSAHLGHVFTDGPR
                     ELGGLRYCINSASLRFVAKDEMEKAGYGYLLPYLNK"
     gene            20997..22721
                     /locus_tag="VVO18_001151"
     CDS             20997..22721
                     /locus_tag="VVO18_001151"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398743.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586320.1"
                     /translation="MKYLLSYFKPYIKESILAPLFKLLEAVFELLVPMVIAGIVDQSL
                     PQGDQGHLWMQIGLLLIFAVIGVLVALIAQFYSAKAAVGFAKELTNDLYRHILSLPKD
                     SRDRLTTSSLVTRLTSDTYQIQTGINQFLRLFLRAPIIVFGAIFMAYRISAELTFWFL
                     VMVAILTIVIVGLSRLVNPLYSSLRKKTDQLVQETRQQLQGMRVIRAFGQEKRELQIF
                     QTLNQVYARLQEKTGFWSSLLTPLTYLIVNGTLLVIIWQGYISIQGGVLSQGALIALI
                     NYLLQILVELVKLAMLINSLNQSYISAKRIEEVFVEAPEDIHSELEQKQATRDKVLQV
                     QELTFTYPDAAQPSLRDISFDMTQGQILGIIGGTGSGKSSLIQLILGLYPVNKGRIDL
                     YLDGLSPLNLEQWRSWIAYVPQKVELFKGTIRSNLTLGFNQEVSDQELWQALEIAQAK
                     DFVSEKEGLLDALVEAGGRNFSGGQKQRLSIARAVLRQAPFLILDDATSALDTITESK
                     LLKAIRENFPNTSLILISQRTSTLQMADQILLLEKGELLAVGKHDDLMKSSQVYCEIN
                     ASQHGKED"
     gene            22723..24471
                     /locus_tag="VVO18_001152"
     CDS             22723..24471
                     /locus_tag="VVO18_001152"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586321.1"
                     /translation="MKRQTVNQTLKRLAVDLASHPFLLFLAFLGTIAQVGLSIYLPIL
                     IGQVIDQVLVAGSSPVFWQIFLQMLLVVIGNTLVQWANPLLYNRLIFSYTRNLRERII
                     HKLHRLPIAFADRQGNGEMVSRVTTDIEQLAAGLTMIFNQFFIGVLMILVSILAMLQI
                     HLLMTLLVLLLTPLSMVISRFIAKKSYHLFQKQTETRGIQTQLIEESLSQQTIIQSFN
                     AQTEFIQRLREAHDNYSGYSQSAIFYSSTVNPSTRFVNALIYALLAGVGAYRIMMGSA
                     LTVGRLVTFLNYVQQYTKPFNDISSVLAELQSALACVERIYGVLDSPEVAETGKEVLT
                     SDQVKGAISFKHVSFGYHPEKILIKDLSIDIPAGSKVAIVGPTGAGKSTLINLLMRFY
                     PISSGDILLDGQSIYDYTRVSLRQQFGMVLQETWLTQGTIHDNIAFGNPEASREQVIA
                     AAKAANADFFIQQLPQGYDTKLENAGESLSVGQAQLLTIARVFLAIPKILILDEATSS
                     IDTRTEVLVQDAFAKLMKGRTSFIIAHRLSTIQDADLILVLVDGDIVEYGNHQELMDR
                     KGKYYQMQKAAAFSSE"
     gene            24728..25987
                     /locus_tag="VVO18_001153"
     CDS             24728..25987
                     /locus_tag="VVO18_001153"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TRZ/ATZ family protein"
                     /protein_id="HEU5586322.1"
                     /translation="MKVFQHVNIVTCDQDFHVYLDGILAVKDSQIVYVGQDKPAFLEQ
                     AEQIIDYQGAWIMPGLVNCHTHSAMTGLRGIRDDSNLHEWLNDYIWPAESEFTPDMTT
                     NAVKEALTEMLQSGTTTFNDMYNPNGVDIQQIYQVVKTSKMRCYFSPTLFSSETETTA
                     ETISRTRSIIDEILKYKNPNFKVMVAPHSPYSCSRDLLEASLEMAKELNIPLHVHVAE
                     TKEESGIILKRYGKRPLAFLEELGYLDHPSVFAHGVELNEREIERLASSQVAIAHNPI
                     SNLKLASGIAPIIQLQKAGVAVGIATDSVASNNNLDMFEEGRTAALLQKMKSGDASQF
                     PIETALKVLTIEGAKALGMENQIGSLEVGKQADFLVIQPQGKIHLQPQENMLSHLVYA
                     VKSSDVDDVYIAGEQVVKQGQVLTVEL"
     misc_feature    26063..26198
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00557"
     gene            26237..26737
                     /locus_tag="VVO18_001154"
     CDS             26237..26737
                     /locus_tag="VVO18_001154"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001287276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L10"
                     /protein_id="HEU5586323.1"
                     /translation="MSEAIIAKKAELVDVVAEKMKAAASIVVVDARGLTVEQDTVLRR
                     ELRGSEVEYKVIKNSILRRAAEKAGLEDLASVFVGPSAVAFSNEDVIAPAKILNDFSK
                     NAEALEIKGGAIEGAVASKEEILALATLPNREGLLSMLLSVLQAPVRNVALAVKAVAE
                     SKEDAA"
     gene            26813..27181
                     /gene="rplL"
                     /locus_tag="VVO18_001155"
     CDS             26813..27181
                     /gene="rplL"
                     /locus_tag="VVO18_001155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="HEU5586324.1"
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAA
                     DAADAGAAKDSFDVELTSAGDKKVGVIKVVREITGLGLKEAKELVDGAPALVKEGVAT
                     AEAEEIKAKLEEAGASVTLK"
BASE COUNT         8096 a         5104 c         6164 g         7981 t
ORIGIN      
        1 aaattttcca gatatctatt gaagcagatt tatttcttca tctttcttct actacctttg
       61 tcactaaatt tgacagacac atattgctga tacaacctct ctacctataa tctcacagtt
      121 aacctgaggc tagtttcata gtttgctatt tgattttcgt tgataataaa aaatgctcct
      181 ccaagacgga agagcatttt ttattgtgat tcttacacat ttacttccta gttttgcagg
      241 aagtctagta taccattttt taaaagaaga gtaaaaaagc aagggtagtt tcttttttga
      301 gaattgtcta aaagtttgat ataatggtag ttatgaatag aataagagtc agcaaaaggg
      361 ttgaaaagaa gcttgctaag gggctagttt tactagaagc cagtgatctt gagaatgtca
      421 atcttaagga tcaggaagta gaggtgcagg gtcaggaagg aaactttctt gggactgcct
      481 acctttctca gcaaaacaag ggcttgggct ggtttgtcag caaagacaag gtggccttca
      541 atcaagcttt ctttgaaacg ttgtttagaa aagccaaaga aaagagaagc gcctactatc
      601 aagatgattt aacaactacc tatcgtctct ttaatcaaga gggagatggc tttgggggtc
      661 tgacagtgga cctttatggc gactacgccg tcttttcttg gtataactct tatgtttatc
      721 agattcgtca gactatatca gaagccttta gacaggtttt ccctgaggtt ttaggggctt
      781 atgagaaaat tcgctttaag ggtttggact atgaatctgc ccatgtttat ggtcaagaag
      841 cacctgactt tttcactgtt ttagaaaatg gtgtcctgta tcaagtcttt atgaatgatg
      901 gcttgatgac aggaattttc ctagaccagc atgaggttcg cggtagttta gttgacggct
      961 tggctatggg taaatccttg ctcaatatgt tttcctacac agcggctttt tcagtagctg
     1021 cggccatggg aggagctagc cagacaactt ctgttgatct agccaaacgt tcacgagaat
     1081 tgtctcaagc gcattttcag gcaaatgggc tcagcacaga cgagcatcgt tttatagtca
     1141 tggatgtctt tgagtatttc aaatatgcca aacgcaaaaa cttgacctac gatgtgattg
     1201 tcctagatcc gcctagcttt gctcggaata aaaaacaaac tttctctgtg gccaaggatt
     1261 atcacaagtt gatttcccag agtcttgaga ttttaaatcc gggagggatt atcattgcca
     1321 gtaccaatgc tgccaatgtt tcccgtcaga aatttacaga acaaattgat aaaggctttg
     1381 caggaagaag ttaccagatt ttaaacaaat atggtcttcc agcagatttt gcctataata
     1441 aaaaagatga aagtagtaat tacctcaagg tgattagtat gaaggttagt aaatgaaatt
     1501 aatcgtttca gtaatgccaa gaagtttaga ggaggctcag gctctggatg ccacgaggta
     1561 cctggatgcc gacatcattg aatggcgtgc cgactatctg cctaaagaag cgattttgca
     1621 ggtagctcca gccatttttg aaaaattcgc aggccgtgag ttggttttca cgttacgaac
     1681 tcgctccgaa ggtggagaaa tcgacctttc tccagaagag tatatccatc taatcaagga
     1741 agttgcgcaa ctctatcaac cagactatat tgattttgag tactatagct acaaggatgt
     1801 ttttgaggaa atgctggact tcccaaatct tgttttgagt taccataatt tccaagaaac
     1861 acctgagaac atgatggaaa tcttgtcaga gttgacgatc ctaaatccaa aacttgttaa
     1921 ggttgcggtg atggctcaca cggagcagga tgtcttagac ttgatgaact atacacgagg
     1981 ctttaaaacc ctcaatcctg aacaggaata tgtgaccatt tctatgggta aggtgggcaa
     2041 ggtctctcgt atcactgcgg atgtgactgg ttcgagttgg tcttttgcca gtctggatga
     2101 ggttagtgcc cctgggcaga tttctctagc tagcatgaaa aaaatcaggg agattttgga
     2161 tgaagcttga tggctataca cgtttaactg cagttgttgc caatcctatt aagcattcta
     2221 tttctccctt catccacaat agagcctttg aggcgacagc taccaacggt gcttatgtgg
     2281 cttgggagat tgaagcgagt gacttggcag aaacagtggc caatattcgt cgctaccaga
     2341 tgtttggcat caatctgtcc atgccctata aggagcaggt gattccttat ttggataagc
     2401 tgagcgatga agcgcgcttg attggtgcgg ttaatacggt tgtcaatgag aatggcaatt
     2461 taattggata taatacagat ggcaagggat tttttaagtg cttgccttct tttacaattt
     2521 caggtaaaaa gatgaccctg ctgggtgcag gtggtgcggc taaatcaatc ttggcacagg
     2581 ctattttgga tggtgtcagt cagatttcgg tctttgttcg ttccgtttct atggaaaaaa
     2641 caagacctta cctagacaag ttacaggagc agacaggctt taaagtggat ttgtgtgctt
     2701 tagaatatgt ttctgaactg caagcaagga ttgccgagtc ggatttgcta gttaatgcca
     2761 ccagtgtggg catggatggc caatcctctc ctgttcctga aaacatagtc ttaccagaaa
     2821 ctctcttagt tgcagatatc atataccaac cctttgaaac accgtttttg aaatgggcta
     2881 gaagtcaggg caatccagca gtcaatggtc tgggaatgtt actctatcaa gctgcagaag
     2941 cttttcaact gtggacaggc aaggaaatgc cgacagaaga gatttggcag tctttaacag
     3001 aaaaatacca ataaagaaag ggagactctc ctatgaaaat cagaatcgat attcctcatc
     3061 atccttatga tattcagatt gaaaaaggtt gtatggccca ggctggtcag tggttgcgag
     3121 aactctggca accgcaaaag gtagtcattg tgacagataa ccatgtagcc tctctctatg
     3181 cagagaaggt caagctcagc ctagaagatg ctggttttca ggtagctgtt tttgatttct
     3241 tggaaggtga agaaagaaag aatttaacta ctgttcagaa agtctatgaa tttctagtca
     3301 agcaaggtct gactcgtagc gatggaatcg tggctcttgg tggtggcgtt gttggggacc
     3361 tggctggctt tgtagcctct acctatatgc ggggtattca ctttgttcag attccgacta
     3421 gtttgacagc tcaggttgat tcttctatcg gtggaaagac aggcgttaac acaccatttg
     3481 ctaaaaatat ggtggggacc tttgctcaac cagatggggt tctgattgat ccacttgttc
     3541 ttgaaaccct cggaaaaaga gagttgattg aagggatggg tgaagttatc aagtatggct
     3601 tgattgagga tccagaactg tgggctctct tgacggggct gaatggttct gttgagagca
     3661 ttttggaaca tgcagagacc ttgattgaac attcttgtca ggtgaagcgc aagatggtgg
     3721 ttgaagatga gttggacaat ggtattcgtc tttacctcaa ttttggccac actattggcc
     3781 atgccatcga agcgactgcc ggttatggca aggtcatgca tggagaggct gttgccatgg
     3841 gaatggtaca gatttccaag attgctgagg aaaaaggcct catgccagct ggcattaccc
     3901 aatctatcac agagatgtgt cagaaattcg gcttgcctgt tgactatgaa aattgggaag
     3961 ttgacaagct ttatcaggct cttactcatg acaagaaagc gcgtggtaac accttgaaat
     4021 tggtcttggt gccagagctt ggttcagcga ccattcatcc agtttctctg gaagagatga
     4081 aagactactt ggtaaaataa ggagagtgta tgagatattt aactgcagga gaatcacacg
     4141 gcccccgtct aacagctatt attgagggaa ttccagctgg acttccattg acagctgagg
     4201 atatcaatga ggaccttaga cgccgtcagg gtggctacgg tcgtggtggt cgtatgaaga
     4261 ttgagaatga ccaggttgtc tttacttcgg gcgttcgcca cgggaagacg acaggggcgc
     4321 ctattactat ggatgtcatc aataaggacc accagaaatg gctggacatc atgtctgcgg
     4381 aggacattga agaccgtctt aaaagcaagc ggaaaattac tcatcctcgc ccaggtcatg
     4441 ccgatttggt tggggggatt aagtaccgtt ttgatgattt gcgaaattct ttggagcgtt
     4501 catcagctcg tgaaaccacc atgcgggtgg cagttggtgc agtagccaaa cgcctcttgg
     4561 ctgagctgga tatggagatt gccaaccatg tcgtggtctt tggtggcaag gaaatcgatg
     4621 ttcctgaaaa tctgacagtc gctgaaatta agcaaagagc tgcccagtct gaagtttcta
     4681 ttgtcaacca agaacgagaa caggaaatca aggactatat tgaccaaatc aaacgtgatg
     4741 gtgataccat cggtggggtt gtggagacag tcgtcggagg cgttccagtt ggtcttggtt
     4801 cctatgtcca atgggataga aaattggatg caagattggc tcaagctgtt gtctctatca
     4861 atgcctttaa aggggtggaa tttggtcttg gctttgaggc tggttatcgt aaaggcagcc
     4921 aagttatgga tgaaattctc tggtctaaag aagacggtta tactcgccgt accaataatc
     4981 taggtggttt tgaaggtggt atgactaatg ggcaacccat cgttgttcgt ggggtcatga
     5041 aacccattcc tactctttat aaacctctta tgagtgtgga tatcgaaacc cacgaacctt
     5101 acaaggcaac cgtggagaga agtgatccga ctgctcttcc agctgcagga atggtcatgg
     5161 aagcagttgt agcaacggtt ctggcgcaag aaatcctcga aaaattctca tcagataatc
     5221 ttgaggaact aaaagaagcg gtagccaaac accgagacta tacaaagaac tattaaggag
     5281 ttcctatggc aaaaacaatc tatatcgcag gtcttgggtt gattggagcc tctatggcac
     5341 ttggtatcaa acgcgatcat ccagattatg aaattttagg ttataatcgt agtcaagctt
     5401 cgagagatat cgccttgaaa gaaggcatga ttgaccgtgc aacggatgat tttgctagtt
     5461 ttgctccttt ggcagatgtc attatactca gcttgccaat caaacaaact attgctttca
     5521 ttaaggagtt ggccaatttg gatttgcgag aaggcgttat tatttcagat gctggttcga
     5581 ccaagtcaac cattgtggat gcggcggagc agtatttggc tggcaagtct gttcgctttg
     5641 tcggggccca tcccatggct ggtagtcaca agacaggggc tgcttcggca gatgtcaatc
     5701 tttttgaaaa tgcctattat atctttacac cttcaagcct gacaagtcag gacacgctta
     5761 aggaaatgaa ggatctgctt tcaggtcttc atgctcgttt tatcgagatt gatgccaagg
     5821 agcatgatcg tgtcacttct cagattagcc attttcctca tattttggct tctagtctca
     5881 tggagcagac tgcggtctat gctcaagagc atgagatggc aaggcgcttt gcggcaggtg
     5941 gttttcgaga tatgacccga attgcggaaa gcgagccagg aatgtggacc tccattctct
     6001 tgtccaatag cgagaccatt ctggatagaa ttgaggattt caaggaacgt ttggaagtga
     6061 ttggtcaggc cattagtaag ggagatgaag agcaaatttg gaactttttt aaccaagcgc
     6121 gtgaacaacg ccagaccatg gaaatccata agcgtggtgg tgtggatagc tcttacgacc
     6181 tctatgttga cgttcctgat gaagaagatg tcatcctgcg gattttggaa ctgctacgtg
     6241 gaacttcctt ggttaacatc cacatcaacg aggaaaatcg tgaggatatt cacggaatcc
     6301 tacaaatttc atttaaaaat gctcaagact tggaaagagc tgagcatctc ataacagaaa
     6361 ataccgacta tacagtcgtc atcaaataag gagaagaaca tgtcaaatat ttacgatagt
     6421 gcaaacgaac tcagtcgcgg tctacgcgga ttaccagaat acaagactgt taaagcagct
     6481 aaagatgcga ttgcagcaga tgctgaggca agcaaaatct ttacagaata tcttgccttt
     6541 caagaggaaa ttcaaaaact agcacagaca ggtcaaatgc cagatgcgtc cttccaagct
     6601 aagatggaag gctttggtaa acagattcaa ggaaatagcc tcttgtcaga attctttacc
     6661 aagcaacaac aattggccat ttacctttct gacattgaaa aaattgtttt tgaaccagtt
     6721 tcagaattgc tgaaataaga aaagaacgat cctaaagtca ggaattttta aggaatttct
     6781 ggctttttat gataaaatag gtaaaagtat tgcaagtatg aggtccagta tgaaactaaa
     6841 aacaaacatt cgccatttac atggtagtat ccgcgtccca ggtgacaagt ctatcagcca
     6901 ccgttccatt atctttggaa gtttggctga gggtgagacc aaggtttatg atattctgcg
     6961 aggtgaagac gtcctttcga ccatgcaggt ttttcgtgac cttggtgttg aaattgagga
     7021 taaagatggg gttattacca ttcaaggtgt aggcatggct ggcttaaaag cgccacaaaa
     7081 tgcccttaat atgggaaatt ctggcacctc gattcgcctg atttcaggtg tccttgctgg
     7141 tgcagatttc gaagtagaga tgtttggaga tgatagtctt tccaaacgtc ctatggaccg
     7201 tgtgaccctt ccactgaaaa aaatgggcgt cagcatttca ggacaaactg aacgagactt
     7261 gcctcccctt cgcttaaaag ggacgaaaaa cctaagacct attcattatg agttgccaat
     7321 tgcctctgcc caagtcaagt cagccttgat gtttgcagcc ttacaagcta agggggcgtc
     7381 agttattatc gaaaaagagt gcactcgtaa tcatactgaa gatatgttga aacaatttgg
     7441 tggtcattta agtgtggacg gtaagaaaat catagtccaa ggaccacaaa aattgacagg
     7501 acagaaggtg gtcgtaccag gagatatttc cagtgcagcc ttttggttag tcgcaggttt
     7561 gattgttcca aattctcgtc tagtgctgca gaatgtgggg atcaacgaaa ctcgcaccgg
     7621 tattattgat gtcattcgtg ccatgggtgg aaaattggaa ataactgaaa tcgatccagt
     7681 cgctaaatct gcaaccttga ttgttgagtc ttctgacttg aaaggaacag agatttgtgg
     7741 cgctttgatt ccacgtttga ttgatgaatt gcctattatt gccctacttg cgacccaagc
     7801 ccaaggtgta acagttatca aggatgctga ggagctcaag gtcaaggaaa cagaccgtat
     7861 tcaggttgtg gcagacgcct taaatagtat gggagcagat attactccta cggcagatgg
     7921 gatgattatc aaaggaaaat cagctcttca cggtgctaga gtcaatacgt ttggtgacca
     7981 ccgtatcggc atgatgacag ctatcgcagc cctcttggtt gcagatggag aggtggagct
     8041 tgaccgtgca gaagccatca ataccagcta tcctagtttc tttgatgatt tggagagctt
     8101 gattcatggc taaggtgtta ttagggttta tgggggctgg aaaatcgact attgcaagag
     8161 gcttggacac taattacctt gatatggatg ctctgattga gaagcgccta ggtatgtcca
     8221 ttgcgaattt tttcgctgaa aagggagaag cagcctttcg tcatgtagaa tcagaagtcc
     8281 tagctgattt actacaaaca gaccaagtcg tgtcaactgg aggaggagtg gttatttctc
     8341 agagaaatcg tgacttactc aagactaata cagataacat ctacctgaaa gcagattttg
     8401 aaaccctcta cctacgtatc gcagctgata aggacaatca gcgaccgctt tttctaaata
     8461 atagcaagga agaactagta gctatttttc aagaaagaca ggcttggtat gaggaagtgg
     8521 ctagtcgggt tttggatgtg accaagctaa gcccagagga aattatagag gaactaagat
     8581 gaaaattgct tatctaggtc ccaagggatc attttcacac cacgttgtgc agacagcttt
     8641 tcctcatgag gaattgcagg cttttgccaa cattacagat gtcatcaagg cttatgagca
     8701 aggattagtg gactattctg tggtgccagt tgaaaactct attgagggta gtgttcatga
     8761 aaccttggac tatctttttc atcaggctca catccaagca gtagcagaaa tcgttcagcc
     8821 tattcatcag cagttgatgg tggttccagg ccatactaag attgaaaaga ttttttcaca
     8881 tccacaggcc ttggctcaag gaaagaaatt catcgatgaa caatatccag aggctcaaat
     8941 cgaggtaaca gctagtacag cttatgcggc ccgttttatt tccgaacatc cagatcagcc
     9001 ctttgcagca attgcaccta gaagttctac tgaagaatat ggattggaac tgattgccga
     9061 ggatattcag gaaatggaag ccaatttaac acgtttctgg gttctaggag ctgaaaagcc
     9121 tagtattccc ttgcaagcac aaactgaaaa gatgagtttg gccttgacat tacctgacaa
     9181 ccttccaggt gcactttata aggccctgtc gacctttgct tggcgaggaa ttgacttgac
     9241 aaaaattgaa agtcgtccac tcaagacagc actgggtgaa tactttttca ttatcgatgt
     9301 ggattatacc gataaggact tggtccactt tgcccaaaaa gaattagaag cgattggaat
     9361 ccagtataaa attctgggtg cctatcctat ttatccaata tcagaccatg gaaaggagag
     9421 aagatgagta aagaaaatcc cttaagtcat catgagcagt tgcgttatga ttatttgcta
     9481 aaaaatattc actatctcaa tgagagagaa aaaaatgagt ttgcctattt gcaagaaaag
     9541 ctaactcttg ctaggggaaa tagtagctct agcttggaac aagaaagaga agagcaggtt
     9601 gacttaccaa gctatgcgaa ccggagtcgc tcacaatcca aatcacaagc actctctttc
     9661 cctccaaaaa agaaaagacg gaagctccgt cttaaacgaa tttttatggt gattttttca
     9721 cttttggtct gtgtggcttt ggccatggta ttcatgtttt tgcgtggtta ccaagatgct
     9781 agcgcaaaga aaactgctga tgcccgggca gctcaagtag aagtctttaa tggtcaggac
     9841 actagagatg gagttaatat tttaatcatg ggtactgatg gtcgaatcgg ccagaacagt
     9901 gttgagacac gaactgactc tattatggta ttaaatgtcg ggggctcaga taagaaaatg
     9961 aagctagtca gtttcatgcg tgataatttg gtctatatag atggttatag tcaagtgatt
    10021 aacggtagaa aacagacaga taacaagtta aacgtagcct acgagttagg agaacaagag
    10081 gggcaaaaag gggcagaaat ggttcgccaa gtcttgaaag ataattttga cttggacatt
    10141 aagtactacg ccttggttga tttccaggcc tttgccacag cgattgacac gcttttccct
    10201 gatggggtga cgattgatgc tcaattttca acattgaatg ggcgtcccct aacagaagct
    10261 acagtcggag atgatttata cgctaccgag actgagtctc caacccaaac cattaaagtc
    10321 ggaaaacagc agatgaatgg ctcgaccctg ctcaattatg ctcgtttccg tgatgatgat
    10381 gaggcggatt acggccgtac aaaaagacag caacaagttt taacagcaat tttagagcaa
    10441 attaaagatc ccactaaact tttcactggt tctgaagctc ttggaaaggt ttttgctatg
    10501 acctcaacca acgtccccta tactttcctc ctaacaaacg gtttatctgt tttggatgga
    10561 gcaaaaaatg gtattgaaaa attgacgatt ccagaactgg gtgactgggt agatgcctat
    10621 gatgtttatg gaggcttggg cttgctggtt gatcaaaaca aatatcaaac caagctcgct
    10681 caaatgggct tgagataaga taatactcaa tgaaaattaa agtgcaaact aggaagctag
    10741 ccgcaggctg ctaaaaacac agttttgagg ttgtagataa gactgacgaa gtcagttacc
    10801 tatacctacg gcaaggtgaa gctgacgtgg tttgaagaga ttttcgaaga gtataagaca
    10861 gaaaaatcaa agtttgatag ctatttggat agcagtcagg ctttgatttt ttacagtctg
    10921 caatagattt tcaccccttg tttgtggtat aatgaaacga tacgatagaa agaataatga
    10981 acaatatgac tgatttaaaa gcaattcagg ctcgtagtct ggagatggct gaatattttg
    11041 tggccttttg taaagaacat gatttgctct gttatctctg tggcggaggc gctattggtg
    11101 cccttcgaaa caagggattt attccttggg acgacgacct agactttttt atgcctcgta
    11161 aagattatga gaaattagca gaattatggc ctcgttatgc agatgaacgt tatttcttgt
    11221 caaagagtca taagaatttt gttgatcgta atctttttat taccattcgt gacaaggaaa
    11281 ccacctgtat caagccttat cagcaggatt tggatttgcc acatggtctg gccttggata
    11341 ttttgccttt ggattattat ccgaaaaatc cagctgagcg gaaaaaacag gttcgttggg
    11401 ccttgattta ttcactcttt tgtgcgcaaa ctattccaga aaagcatggt gctctcatga
    11461 aatggggaag tcgcatttta ctgggtttga ctccaaaatc tctccgttat cgcatctgga
    11521 aaaaagctga gaaagaaatg actaagtatg atttggctga ttgtgatggc attacagaat
    11581 tatgctcagg tcctggctac atgagaaaca agtacccaat cacatctttt gaagacaatc
    11641 ttttcttgcc atttgaagga acagagatgc ctattccaat cggctatgat gtctatctca
    11701 gaactgcttt tggggattat atgacgcctc caccagcaga caagcaggta ccgcatcatg
    11761 atactgtcat tgctgatatg gataagtctt atacaaaata caagggagaa tatggtggct
    11821 aagaaaaaaa tcttattttt tatgtggtct ttttctcttg gaggtggtgc agagaagatt
    11881 ctatcaacca ttgtttcaaa tctggatcca gaaaagtatg atattgatat tcttgaaatg
    11941 gagcactttg acaagggata tgaatctgtt ccaaagcatg tacgcatttt aaaatccctt
    12001 caagattatc gccaaaccag atggttacga gcttttttgt ggagaatgag aatttatttt
    12061 ccaagactga ctcgtcgttt gcttgtaaaa gatgattatg atgttgaagt ttcttttacc
    12121 attatgaatc caccactgtt gttctctaaa agaagagaag tcaagaagat atcttggatt
    12181 catggaagta ttgaagaact tcttaaggat agctctaaaa gagaatcaca tagaagccag
    12241 ttggatgctg cgaatacaat tgtagggatt tcaaaaaaga ccaggaattc tatcaaggaa
    12301 gtttatccag attatgcttc taaattacag acaatctaca atggatatga ttttcagact
    12361 attctagaaa aatctcaaga gaagatcgat atcgagattg ctcctcaaag tatctgtact
    12421 atcggacgga ttgaggaaaa taagggttct gaccgtgtag tggaagtgat acgattatta
    12481 caccaagagg gaaaaaacta tcatctctat tttatcgggg ctggtgatat ggaagaggaa
    12541 ctgaaaaaac gagtcaaaga gtatgggatt gaggactatg tacatttcct tggttatcaa
    12601 aaaaatcctt atcagtatct atctcagacg aaagttctct tgtctatgtc taaacaagaa
    12661 ggttttcctg gagtgtatgt ggaggccttg agtctgggac tcccttttat ctctacggac
    12721 gttggagggg ctgaggaatt atcccaagaa ggacgatttg gacaaatcat tgagagcaat
    12781 caagaggcag ctcaggcgat tactaattac atgacttctg cctcaaactt tgatgtcgat
    12841 gaggctagcc aattcattca acaatttaca attacaaaac aaatcgaaca agtagaaaaa
    12901 ctattagagg agtagcatgg aaactgcatt aattagtgtg attgtgccag tctataatgt
    12961 ggcgcagtac ctagaaaaat cgatagcttc cattcagaag cagacctatc aaaatctgga
    13021 aattattctt gttgatgatg gtgcaacaga tgaaagtggt cgcttgtgtg attcaatcgc
    13081 tgaacaagat gacagggtgt cagtgcttca taaaaagaac gaaggattgt cgcaagcacg
    13141 aaatgatggg atgaagcagg ctcacgggga ttatctgatt tttattgact cagatgatta
    13201 tatccatcca gaaatgattc agagcttata tgagcaatta gttcaagaag atgcggatgt
    13261 ttcaagctgt ggtgtcatga atgtctatgc taatgatgaa agcccacagt cagccaatca
    13321 ggatgactat tttgtctgtg attctcaaac atttctaaag gaatacctca taggtgaaaa
    13381 aatacctggg acgatttgca ataagctaat caagagacag attgcaactg ccctatcctt
    13441 tcctaagggg ttgatttacg aagatgccta ttaccatttt gatttaatca agttggccaa
    13501 gaagtatgtg gttaatacta aaccctatta ttactatttc catagagggg atagtattac
    13561 gaccaaaccc tatgcagaga aggatttagc ctatattgat atctaccaaa agttttataa
    13621 tgaagttgtg aaaaactatc ctgacttgaa agaggtcgct tttttcagat tggcctatgc
    13681 ccacttcttt attctggata agatgttgct agatgatcag tataaacagt ttgaagccta
    13741 ttctcagatt catcgttttt taaaaggcca tgcctttgct atttctagga atccaatttt
    13801 ccgtaagggg agaagaatta gtgctttggc cctattcata aatatttcct tatatcgatt
    13861 cttattactg aaaaatattg aaaaatctaa aaaattacat tagaacgggg gtgaccaagt
    13921 gattgatggg aaacgattat tatttagttt gaccatagtc agttatgcct tgacgctagt
    13981 aagtggaatt gtgtatctgt ttaataataa taatgttagc ttactttcta ctttattgtt
    14041 cttgttggtt agtagcttaa ttgcttgttg gaatgatatc aagtattact taatccattt
    14101 tattttctat ttaaccattt ttgtatttct ggtatcaaga ccgaccattg attattttag
    14161 ggatggtgct ttggatacct atcatccaat agcctatcgt tttgccttta tagttgtcat
    14221 ggtttcgatt ctgggcttga ccacaggagg cattctggct cgttacttca tagctaggaa
    14281 gaaaataaaa gtagcaaata taggaaattc tctaaaagag gtttatatca agcggttacg
    14341 ctttgtatca ctagtagttt ttcttctaac ctatcctttc tatttcattc ggttatttga
    14401 acggctcttg tatcgtttgc agacttccta ctatgcctac tatgcaaatt ttgaaagtaa
    14461 actgccttat tttacctaca ttttgtctac ctttacggtc tatgcaatgt gtatgtatct
    14521 ggcaaccaag ccaaagaaat tgcaggccac agcagtgctt gtctccttta ttgcagctaa
    14581 tactattcat ttggcaattg ggacacgaaa tccctttatt ttaagtattt tatttgcttt
    14641 tgtttattac tttatgcggg agcaaactga aaaaggaaaa tggattgggt ttaaagaaaa
    14701 gttagcgatt tttgtaggtt ctcctattct catgttagcg atgggagtac tcaattatgt
    14761 acgggataat gtccaagttt cccatacagg tttctgggat atcttacttg actttatcta
    14821 taaacaaggg actagttttg gtgttctggc tcgaggtttt ctatttaaca gtagcctccc
    14881 ttaccgagat ttccgtaatt ttacttttgg tcctgttctt gattattttg caagggggag
    14941 tttgggagcc attttcggag gaaaagcctt tgaacataca accaatagtg tggaactagc
    15001 tattgatagt aatagttatg cccacaatct atcctatctt gtcttgaaca aggaatactt
    15061 gaaagggcat ggtatcggaa gtagttatat catggagttg tataccgact atggtatgat
    15121 tggagtcttt ctgcttagtt tcttactcgg cgtattattt atagccatgc tgcaagtagc
    15181 ctatcgctca aggacaatcc tatttgcttt atccctactc atcttgaata atctattctt
    15241 tatgccaaga agcagctttt cagaaagttt cttcaattta tttacaatgc aattctgggg
    15301 aattgttctt gtgattatat ttgtagcaaa aatgcttaca aaggaaaact agtatctact
    15361 aaacaaagga gaaaaaaatc atgtttgaac attattcagt agctgatttg tttgcaaatc
    15421 tttataaaaa gcgaaaagca aatattttag ctctcatcgc tttatttgct ctcattgctg
    15481 taccatttac aattaaagca gttaggaata aaaacactgt caaagataca acaagttatt
    15541 caacttatct tatctataaa atcactcctc cagaagattc ggccaaaacg attttgaatc
    15601 atcaaattgg tggttatagt gatttttatg ggaaattgat tgatggtaat ttgaatggag
    15661 cttatctttt caatgatgta gaacccagtg agttgaaaaa aattgccagt gaattagaca
    15721 cgacagaaac aaccttgaaa aattcaacga atgactattg gtggaaaaaa ttgaccgtct
    15781 actatatgat tgacgatgca ggggttggtg tgaaaatttt gacatcaagt aaagatgcca
    15841 atgacttgtt agagaaaaaa attgatgggt tgattgagaa atttaaacat gcttatgcaa
    15901 atgtgaaaat tgaaaaactg gaaaccatca actctaaaga attgaacgca aatggtgaaa
    15961 cagcgcttgg cttaaatgtg aaaaatctga ttcttcgttt agttgttatt ggagtggttt
    16021 gtgtgatttt ggttgtgatg ggaaatgtgt tagtttatct ctttaatcca acaatcaata
    16081 gagtaggtga tttttctcag tatcaaattg attttgtaac agagattaca acaattgcta
    16141 acctagcaga tgttttgtca tacaaaaata ctggacagga attgaccatc gttagctcaa
    16201 ataaagctat cctagataaa ttgaaacaga gtcaagaagc tttaaaagga atgcattttg
    16261 tagatttaca ggatgtatca tctcttttgg aaagagatac agtccttctt gttgaagagt
    16321 acggagtgac tcgttataag aaatttgagc aaagtcttca aattctcaga aacttaaatc
    16381 gttctatcct cggtgtagca acctttaaat tataagtatt ctgatgtata gggtcttcaa
    16441 agtcggctaa gagccgattt tgaaggcttt ttctatctgt ctgcagaaat tttctcttgg
    16501 agtctcctat agaaagaccc tagggaaaat ctatccgtat agaggagcct tcttttgata
    16561 aaatcgtaaa aatctagtat aatagataga actgaaagta tgaggttact agcaatgaaa
    16621 atgaaacaaa ttagtgatac aactttaaaa atcacgatgt ctttagagga tttgatggat
    16681 cgtggaatgg agattgctga ctttctcgtt cctcaagaaa aaacagaaga gttcttttat
    16741 gctatcttgg atgagctaga gatgcctgat agctttctgg atacaggcat gttgagcttc
    16801 cgtgtgactc caaaacctga taaggtagat gtctttgtga ccaagtcaaa gattgaccaa
    16861 aatctagatt ttgaagactt atcggatttg ccagatatgg aagaattggc tcaaatgtct
    16921 ccagatgaat ttatcaaaac cctggaaaaa agcatcgcag acaaaaccaa ggatgatatc
    16981 gaagccattc aatctcttga gcaagttgaa gccaaggaag aagagcaaga gcaggctgaa
    17041 caagaagctg agagtaagaa agaaccttac atctactaca tcctttcttt tgctaagttg
    17101 gctgacttgg tagcttttgc caagacagtg acttttgaaa tggaaacttc tgaactctac
    17161 aaaatgaacg agcgctatta tttgaccatt ttagtggata ttgaaaatca tccaagccca
    17221 tatccagctt ggctgttggc ccgtatgcgc gagtttgcag acgatagtga tatcagtcgc
    17281 tcagtcttac aagagtatgg tcaagtcttg atgagtcacg atgcagtgct caatctgcaa
    17341 aaaatcggct aatcctttct ggaaagctat tttcagattt taagaagagc gaatcgtctg
    17401 attcgttttt tctttttata ctgaaatagt gatttactat aataggaatt ttcacaaaat
    17461 tctgttataa tggctatatt agaaaatttc gaggagataa agatgacagt taaaattgct
    17521 ttactaggat ttggtaccgt tgcaagtggt gtgcctttcc tcctaaagga aaatggagga
    17581 aaaatcaatc aatcagcaca ttcagatatc aaagttgcta aggtattggt caaggatgaa
    17641 gatgaaaaaa atcgcttgct tgcagcaggg aatgacttta actttgtaac caatgtggat
    17701 gatattttat cagaccatga tattactatc gtagtggaat tgatggggcg tattgagcct
    17761 gctaaaacct ttatcactcg tgccttggaa gctggaaaac acgttgttac tgctaacaag
    17821 gaccttttag ctgtccatgg cgcagaattg ctagaaatcg ctcaagctaa caaggtagca
    17881 ctttactacg aagcagcagt tgctggtggg attccaattc ttcgtacttt agcaaattcc
    17941 ttggcttctg ataaaattac gcgcgtgctt ggagtagtca acggaacttc caacttcatg
    18001 gtgaccaaga tggtggaaga aggctggtct tacgatgatg ctcttgcgga agcacaacgt
    18061 ctaggatttg cagaaagcga tccgacgaat gacgtagatg ggattgatgc agcctacaag
    18121 atggttattt tgagtcaatt tgcctttggc atgaagattg cctttgatga tgtagcccac
    18181 aagggaatcc gcaatatcac accagaagac gtagctgtag ctcaagagct tggttacgta
    18241 gtgaaattgg ttggttctat tgaggaaact tcttcaggta ttgctgcaga agtgactcca
    18301 accttcctac ctaaagcgca cccacttgct agtgtgaatg gcgtaatgaa cgctgtcttt
    18361 gtagaatcta tcggtattgg tgagtctatg tactacggac caggtgcggg tcaaaaacca
    18421 actgcaacaa gtgttgtagc tgatattgtc cgtatcgttc gtcgtttgaa tgatggtact
    18481 attggcaaag acttcaacga atatagccgt gacttggtct tggcaaatcc tgaagatgtc
    18541 aaagcaaact actatttctc aatcttggct ctagactcaa aaggtcaggt cttgaagttg
    18601 gctgaaatct tcaatgctca agatatttcc tttaagcaaa tccttcaaga tggcaaagag
    18661 ggtgacaagg cgcgtgtcgt tatcatcaca cacaagatta ataaagccca gcttgaaaat
    18721 gtctcagctg aattgaagaa ggtttcagaa ttcgacctct tgaatacctt caaggtgcta
    18781 ggagaataag atgaagatta ttgtacctgc aaccagtgcc aatatcgggc caggttttga
    18841 ctcggtcggt gtagctgtaa ccaagtatct tcaaattgag gtctgcgaag aacgagatga
    18901 gtggctgatt gaacaccaga ttggcaaatg gattccacat gatgagcgta atctcttgct
    18961 caaaatcgct ttgcaaattg taccagactt gcaaccaaga cgcttgaaaa tgaccagtga
    19021 tgtccctttg gcgcgcggtt tgggttcttc cagctcggtt atcgttgctg ggattgaact
    19081 agccaaccaa ctgggtcaac tcaacttatc agaccatgaa aaattgcagt tagcgaccaa
    19141 gattgaaggg catcctgaca atgtggctcc agccatttat ggtaatctcg ttattgcaag
    19201 ttctgttgaa gggcaagtct ctgctatcgt agcagacttt ccagagtgtg attttctagc
    19261 ttacattcca aactatgaat tacgtactcg cgacagccgt agtgtcttgc ctaaaaaatt
    19321 gtcttataag gaagctgttg ctgcaagttc tatcgccaat gtagcggttg ctgccttgtt
    19381 ggcaggagac atggtgaccg ctgggcaagc aatcgaggga gacctcttcc atgagcgcta
    19441 tcgtcaggac ttggtaagag aatttgcgat gattaagcaa gtgaccaaag aaaatggggc
    19501 ctatgcaacc tacctttctg gtgctgggcc gacagttatg gttctggctt ctcatgacaa
    19561 gatgccaata attaaggcag aattggaaaa gcaacctttc aaaggaaaac tgcatgactt
    19621 gagagttgat acccaaggtg tccgtgtaga agcaaaataa agaatagaat ataggatggg
    19681 gaaactcttg accagagggg ttcatatcct ttttgtgaaa agaagtttat actcaatgaa
    19741 aatcaaagag caaactagga agctagccgc aggttgctca aagcactgct ttgaggttgt
    19801 agataagact gacgacgtca gctcaaaaca gtgttttgag gttgtggata gaactgacga
    19861 cgtcagctca agacactgtt ttgaggttgc agatagaact gacgaagtca gtaaccatac
    19921 ctacggtaag gtgacgctga cgtggtttga agagattttc gaagagtatt agttaaaaac
    19981 gtgataaagg agaaataaaa atggcagaaa tttatctagc aggtggttgt ttttggggcc
    20041 tagaggaata tttttcacgc atttctggag tgctagaaac cagtgttggc tacgctaatg
    20101 gtcaagtcga aacgaccaat taccagttgc tcaaggaaac agaccatgca gaaacggtcc
    20161 aagtgattta cgatgagaag gaagtgtcac tcagagagat tttactttat tatttccgag
    20221 ttatcgatcc tttatctatc aatcaacaag ggaatgaccg tggtcgccaa tatcgaactg
    20281 ggatttatta tcaggatgaa gcagatttgc cagctatcta cacagtggta caagagcagg
    20341 aacgcatgct gggtcgaaag attgcagtag aagtggagca attacgccac tacattctgg
    20401 ctgaagacta ccaccaagat tatctcagga agaatccttc aggttactgt catatcgatg
    20461 tgaccgatgc tgataagcca ttgattgatg cagcaaacta tgaaaagcct agtcaagagg
    20521 tgttgaaggc cagtctatct gaagagtctt atcgtgtcac acaagaagct gctacagagg
    20581 ctccatttac caatgcctat gaccaaacct ttgaagaggg gatttatgta gatattacga
    20641 caggtgagcc actctttttt gccaaggata agtttgcttc aggttgtggt tggccaagtt
    20701 ttagccgtcc gatttccaaa gagttgattc attattacaa ggatctgagc catggaatgg
    20761 agcgaattga agttcgttct cgttcaggca gtgctcactt gggtcatgtt ttcacagatg
    20821 gaccgcggga gttaggcggc ctccgttact gtatcaattc tgcttcttta cgctttgtgg
    20881 ccaaggatga gatggaaaaa gcaggatatg gctatctatt gccttactta aacaaataaa
    20941 acagagagtg gggcttccca ctttcttcat ttctagaata tgaatagaag ggatttatga
    21001 aatacctatt atcttacttc aaaccctaca tcaaggaatc aattttagcc cccttgttca
    21061 agctgttaga agctgttttt gagctcttgg ttcccatggt gattgctggg attgttgacc
    21121 aatctttacc tcagggagat caaggtcatc tctggatgca gattggcctg ctccttatct
    21181 ttgcagtaat tggcgtttta gtggccttga tagctcaatt ttactcagca aaggcagcag
    21241 taggctttgc taaggaattg acaaacgatc tttatcgtca tattctttcc ttgcccaagg
    21301 acagcagaga ccgtctgaca acttctagtt tggtcactcg cttgacttcg gatacctacc
    21361 agattcagac tggtatcaat caattcctgc gtctcttttt gcgagcgccc attatcgttt
    21421 ttggtgccat ttttatggct tatcgaatct cagctgagtt gactttctgg ttcttagtca
    21481 tggttgccat tttgaccatt gtaattgtag ggttatctcg attggtcaat cctctctaca
    21541 gtagtctcag aaagaaaacg gaccaactgg ttcaggaaac gcgccagcaa ttgcaaggga
    21601 tgcgggttat tcgtgctttt ggtcaagaaa aacgagagtt acagattttt caaaccctta
    21661 accaagttta tgctagatta caagaaaaga caggtttctg gtctagttta ttaacacctc
    21721 tgacctatct gattgtcaat ggaactcttc tcgttattat ctggcaaggc tatatttcaa
    21781 ttcaaggagg agtgctcagt caaggtgctc tcattgctct tatcaattac ctcttacaga
    21841 ttttggtgga attggtcaag ctagccatgt tgatcaattc cctcaaccag tcctatatct
    21901 cagccaagcg aatcgaggaa gtctttgttg aggctccaga ggatatccat tcagagttag
    21961 aacaaaagca agctaccaga gataaggttt tacaagtcca agaattgacc tttacctatc
    22021 ctgatgcggc ccagccttct ctgagagaca tttcctttga tatgactcaa ggacaaattc
    22081 taggtatcat cgggggaact ggttctggta aatcaagctt gattcaactc atacttggac
    22141 tttatccagt aaacaaggga agaattgacc tttatctaga tggattgagt cctcttaatt
    22201 tggagcaatg gagatcttgg attgcctatg tgccacaaaa ggtcgaactc tttaagggaa
    22261 ctattcgttc caacttgact ctaggtttca atcaagaagt atctgaccag gaactctggc
    22321 aggccttgga gattgcgcaa gctaaggatt ttgtcagtga aaaggaagga ctcttggatg
    22381 ctctagttga ggcagggggg cgaaatttct caggtggaca aaaacaaaga ttgtctatcg
    22441 cccgagcagt cttgcgccag gctccgtttc tcatcctaga tgatgcaacc tcggcactgg
    22501 ataccattac agagtccaag ctcttgaaag ctattagaga aaattttcca aacacgagct
    22561 taattttgat ctctcaacga acctcaactt tacagatggc ggaccagatt ctcctcttgg
    22621 aaaaaggtga gttgctagct gttggcaagc acgatgactt gatgaaatcc agccaagtct
    22681 attgtgaaat caatgcatcc caacatggaa aggaggacta gaatgaaacg acaaactgta
    22741 aaccagacgc tcaaacgttt agccgtagat ttagcaagcc atcctttcct ccttttccta
    22801 gcctttctag gaactattgc ccaagttggc ttatcaattt acctacctat tctgattggg
    22861 caggtcattg accaagtcct agtggctggt tcatcaccag ttttttggca gatttttctc
    22921 cagatgctct tggtggtaat aggaaatact ctggtacaat gggccaatcc tctcctctat
    22981 aatcgtctaa tcttctctta taccagaaat ttacgagagc gaatcatcca taaactccat
    23041 cggttaccga ttgcttttgc ggatcggcaa ggcaatggag agatggtcag tcgtgtaacc
    23101 acggatatcg aacagttggc agctggcttg accatgattt ttaaccaatt tttcattggt
    23161 gttttgatga ttttggttag tattctagcc atgctccaaa ttcatctcct catgactctc
    23221 ttagtcttgc tgttgacgcc actgtccatg gtgatttcac gctttattgc caagaaatcc
    23281 tatcatctct tccagaagca aacagagacg aggggaattc agactcagtt gattgaagaa
    23341 tcgcttagtc agcagactat aatccagtcc ttcaatgctc aaacagaatt tatccaaaga
    23401 ttgcgtgagg ctcatgacaa ctactcaggc tattctcagt cagccatctt ttattcttca
    23461 acggtcaatc cttcgactcg ctttgtaaat gcactcattt atgccctttt agctggagta
    23521 ggagcttatc gtatcatgat gggttcagcc ttgaccgtcg gtcgtttagt gacttttttg
    23581 aactatgttc agcaatacac caagcccttt aacgatattt cttcagtgct agctgagttg
    23641 caaagtgctc tggcttgcgt agagcgtatc tatggagtct tagatagccc tgaagtggct
    23701 gaaacaggta aggaagtctt gaccagtgac caagttaagg gagctatttc ctttaaacat
    23761 gtctcttttg gctaccatcc tgaaaaaatt ttgattaagg acttgtctat cgatattcca
    23821 gctggtagta aggtagccat cgttggtcct acaggtgctg gaaaatcaac tcttatcaat
    23881 ctccttatgc gtttttatcc cattagctcg ggagatatct tgctggatgg gcaatccatt
    23941 tatgattata cacgagtatc attgagacag cagtttggta tggtgcttca agaaacctgg
    24001 ctcacacaag ggaccattca tgataatatt gcctttggca atcctgaagc cagtcgagag
    24061 caagtaattg ctgctgccaa agcagctaat gcagactttt tcatccaaca gttgccacag
    24121 ggatacgata ccaagttgga aaatgctgga gaatctctct ctgtcggcca agctcagctc
    24181 ttgaccatag cccgagtctt tctggctatt ccaaagattc ttatcttaga cgaggcaact
    24241 tcttccattg atacacggac agaagtgctg gtacaggatg cctttgcaaa actcatgaag
    24301 ggccgcacaa gcttcatcat tgctcaccgt ttgtcaacca ttcaggatgc ggatttaatt
    24361 cttgtcttag tagatggtga tattgttgaa tatggtaacc atcaagaact catggataga
    24421 aagggtaagt attaccaaat gcaaaaagct gcggctttta gttctgaata agccattctc
    24481 ttttgaaagt ttatggacga aaaaagttgc cttcgagtga cttttttgtt acaatagcta
    24541 gaaaaattgt ttactgtaat actcaatgaa aatcaaagag caaactagga agctagccgt
    24601 aggttgctca aagcacagct ttgaggttgt agatagaact gacgaagtca gtaaccacac
    24661 ctacggcaaa gtgaatctga agtggtttga agagagtaaa acttgtcttt tagaaaagga
    24721 gcctataatg aaagtctttc agcatgtaaa tatcgtgact tgtgatcaag atttccatgt
    24781 ttatcttgat ggaatcttag cagtcaagga ttctcaaatc gtctatgtcg gtcaagataa
    24841 gccagcgttt ttagagcaag ctgagcagat tatagactat cagggagctt ggattatgcc
    24901 tggtttggtc aattgtcaca cccattctgc aatgacaggt ctgagaggga tccgagatga
    24961 cagcaatctc catgaatggc tcaatgacta tatctggcca gcagaatctg agtttactcc
    25021 cgacatgact accaatgcgg tcaaagaagc cctgacagag atgctccagt caggaacaac
    25081 aacctttaac gatatgtata atcccaatgg tgtggatatt cagcaaattt atcaggtggt
    25141 gaaaacttcc aagatgcgtt gttatttttc tccgactctc ttttcttcag agacagaaac
    25201 aactgctgag actataagca gaactcgatc catcatagac gaaatcttaa aatataaaaa
    25261 tccaaatttc aaggttatgg tagcacctca ttctccgtat agctgcagta gagacttgct
    25321 ggaagcgagt ttggaaatgg caaaagagct aaatattccg ctccatgtcc atgtggcgga
    25381 gaccaaggag gagtcaggaa ttatcctcaa acgatacggc aaacgccccc ttgcttttct
    25441 tgaagaactg ggttatttag atcatccgtc cgtatttgct cacggggtcg aattaaacga
    25501 gagagaaatt gaacgcttgg catcttctca agtggctatc gcccacaatc ctatcagtaa
    25561 cctcaaactg gcatcaggaa ttgctccaat tatccagctc caaaaagcgg gagtagcagt
    25621 cggaattgcg actgactcgg ttgcttccaa taacaatcta gatatgtttg aggaaggaag
    25681 gactgcagct cttcttcaga agatgaaaag tggggatgcc agccagtttc caatcgaaac
    25741 agctctcaag gtactgacaa tcgaaggggc taaggccctt ggaatggaaa atcagatagg
    25801 aagtctggaa gtcggcaagc aagcagattt tctggtcatt caaccacaag ggaaaattca
    25861 tctccaacct caggaaaata tgctgtctca cctggtttat gcagttaaat ctagtgatgt
    25921 agatgatgtt tatatcgccg gagaacaggt tgttaagcaa ggtcaagtcc tgacagtaga
    25981 actttaaaag aaaaatcacg aaaaatttta aaaaaagttt gcaaaaatct tgcattcttt
    26041 ttttgactat gctatactta tatacggttt aaaaaaactg cctaagacag taggggagct
    26101 cgactcataa atatcctacc gaggacaaga cgtatcatgt aaaaagaagc gtattgtact
    26161 ttcgtgtcta ggtttgggcg cgtttttctt tttgaaaaat tccccaagca aaataattac
    26221 ggaggtgaac acactaatga gtgaagcaat tattgctaaa aaagcggaac tagttgacgt
    26281 agtagctgaa aaaatgaaag ctgctgcatc tatcgtcgtt gtagacgctc gtggtttgac
    26341 agttgagcaa gatacagttc ttcgtcgtga gcttcgtgga agcgaagttg agtataaagt
    26401 tattaaaaac tcaatcttgc gtcgtgcagc tgaaaaagct ggtcttgaag atcttgcatc
    26461 tgtatttgtt ggaccatctg cagtagcatt ttctaatgaa gatgttatcg caccagcgaa
    26521 aatcttgaac gacttttcta aaaacgctga agcacttgaa attaaaggtg gtgcaatcga
    26581 aggcgctgtc gcatctaaag aagagattct tgcacttgca actcttccaa accgcgaagg
    26641 acttctttct atgctccttt ctgtacttca agcgccagtg cgcaacgttg ctcttgcagt
    26701 caaagcggtt gcagaaagca aagaagacgc ggcttaatct taagctacat agcgtagcct
    26761 agctacgaaa aaaactatta taaaatttaa aacttatttg gaggaaataa caatggcatt
    26821 gaacattgaa aacattattg ctgaaattaa agaagcttca atccttgaat tgaacgacct
    26881 tgtaaaagct atcgaagaag aatttggtgt aactgcagct gctcctgtag ctgttgctgc
    26941 agctgatgca gctgatgctg gtgctgctaa agattcattc gacgttgaat tgacatctgc
    27001 aggcgacaaa aaagttggtg ttatcaaagt tgtacgtgaa atcactggtc ttggtcttaa
    27061 agaagctaaa gaacttgttg acggtgcacc agcacttgtt aaagaaggcg ttgcaactgc
    27121 agaagctgaa gaaatcaaag ctaaattgga agaagctgga gcttcagtta ctcttaaata
    27181 atagagcaac tacattagta gcttaaaaac atgattaaac cgctattctt aggagtagcg
    27241 gtttttcttt ttgtttaaaa aggggcaaac tttttatata gttgtttagg aaataaataa
    27301 tttttgtata attggtttac tactctaaat taacgtagta caaga
//
LOCUS       DAVHIZ010000026        26952 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.026, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000026 DAVHIZ010000000
VERSION     DAVHIZ010000026.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26952)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26952)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26952
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.026"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1032
                     /locus_tag="VVO18_001156"
     CDS             <1..1032
                     /locus_tag="VVO18_001156"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU5586325.1"
                     /translation="SLEYCLPSRTILLNWLAQYRKNGYTIVEKTRGRVPESGKCHPKK
                     VKRTPIEGGKRERRKTEIVQELMTEFSLDILLKAIKLARSTYYYHLKQLDKTDKDQEL
                     KAEIQSIFIEHKGNYAYRRIYLELRNRGYLVNHKRVQGLIKVLNLQAKMRQKRKYSSH
                     KGDVGKKAENLIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLLPVLDGFNSEIIAYN
                     LSTSPNLEQVQTMLEQAFKEKHYENTILHSDQGWQYQHDSYHQFLEGKGIQASMSRKG
                     NSPDNGMMESFFGILKSEMFYGYEKSFQSLKQLEQAIVDYIDYYNNKRIKVKLKGLSP
                     VQYRTKSFG"
     gene            complement(1141..1440)
                     /locus_tag="VVO18_001157"
     CDS             complement(1141..1440)
                     /locus_tag="VVO18_001157"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1827 family protein"
                     /protein_id="HEU5586326.1"
                     /translation="MKLINTTNSHSQLVKSQLESTDATLVEVYSAGNTDVIFTQAPLH
                     YEILISNKHRAIREPEIETIQEFFLKRKIDKASVDEANIKTLYSEKLIGISIPIK"
     gene            complement(1605..2012)
                     /locus_tag="VVO18_001158"
     CDS             complement(1605..2012)
                     /locus_tag="VVO18_001158"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU5586327.1"
                     /translation="MARYGVYAVIPNPEQKQIVLVQEPNGAWFLPCGEIEAGENHQEA
                     LKRELIEELGFTAEIGTYYGQTDEYFYSRHRDTYYYNPAYLYEATSFKEVQKPLENFN
                     HIAWFPIDEAIQNLKRGSHKWAIESWKKQHKIG"
     gene            2138..3011
                     /locus_tag="VVO18_001159"
                     /pseudo
     CDS             2138..3011
                     /locus_tag="VVO18_001159"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="programmed frameshift; internal stop; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            complement(3213..5471)
                     /locus_tag="VVO18_001160"
     CDS             complement(3213..5471)
                     /locus_tag="VVO18_001160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="HEU5586328.1"
                     /translation="MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSL
                     FKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPPTQSGGGYGGNGGYGSQNRGSAQ
                     TPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
                     GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEI
                     RKREDIILFIDEIHEIVGAGSASDGNMDAGNILKPALARGELQLVGATTLNEYRIIEK
                     DAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAAIEAAATLSNRYIQD
                     RFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRD
                     QIAKYKEMQKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKS
                     HVIGQDDAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSA
                     DSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDEVEKAHP
                     DVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSV
                     LGELGNFFSPEFMNRFDGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKV
                     KEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENPSEKDLKAVMTSKGNIQIKSA
                     KKAEVKSSEKEK"
     gene            complement(5700..5930)
                     /locus_tag="VVO18_001161"
     CDS             complement(5700..5930)
                     /locus_tag="VVO18_001161"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005592360.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YkuJ family protein"
                     /protein_id="HEU5586329.1"
                     /translation="MESHLVRIINRLEAMANDGGNLKRNFEREGVVVAEVAYSHDEEN
                     GPIFTLRDVEDRETYTFDSIDLIAMEIYELLY"
     gene            6120..6803
                     /locus_tag="VVO18_001162"
     CDS             6120..6803
                     /locus_tag="VVO18_001162"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001011621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5586330.1"
                     /translation="MNFSFLPKYLPYFNYGAVVTILISICVIFLGTILGVVLAFGQRS
                     KFKPLVWLANLYVWIFRGTPMMVQIMIAFALMHINAPTIQIGILGVDFSRLIPGILII
                     SMNSGAYVSETVRAGINAVPKGQLEAAYSLGIRPKNAMRYVILPQAVKNILPALGNEF
                     ITIIKDSSLLSAIGVMELWNGATTVSTTTYLPLTPLLFAAFYYLIMTSILTVALKAFE
                     KHMGQGDKK"
     gene            6803..7537
                     /locus_tag="VVO18_001163"
     CDS             6803..7537
                     /locus_tag="VVO18_001163"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000140960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5586331.1"
                     /translation="MTETLIKIENLHKSFGKNEVLKGINLEIKRGEVVVIIGPSGSGK
                     STLLRSMNLLEEATKGKVIFEGVDITDKKNDLFAMREKMGMVFQQFNLFPNMTVMENI
                     TLSPIKTKGESREVAEKRAQELLEKVGLPDKADAYPQSLSGGQQQRIAIARGLAMEPD
                     VLLFDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAREVADRVIFMADGVV
                     VEDGTPEQIFEQTQEQRTKDFLSKVL"
     gene            7691..8548
                     /locus_tag="VVO18_001164"
     CDS             7691..8548
                     /locus_tag="VVO18_001164"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000192112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="HEU5586332.1"
                     /translation="MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGDNP
                     ASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPK
                     HIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKN
                     AVVIGRSNIVGKPMAQLLLAKNATVTLAHSRTHNLAKVAAKADILVVAIGRAKFVTAD
                     FVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQ
                     AALRTLDRK"
     gene            8690..9562
                     /locus_tag="VVO18_001165"
     CDS             8690..9562
                     /locus_tag="VVO18_001165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000864675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD(P)H-hydrate dehydratase"
                     /protein_id="HEU5586333.1"
                     /translation="MKVINQTLLEKVIIERSRSSHKGDYGRLLLLGGTYPYGGAIIMA
                     ALAAVKSGAGLVTVGTDRENILALHSHLPEPMAFSLQDQQLLKEQLEKAEVVLLGPGL
                     RDDASGENLVKQVFVNLSQNQILIVDGGALTILARTSLSFPSSQLILTPHQKEWEKLS
                     GITIEKQKEDATASVLTSFPQGTILVEKGPATRIWEVGQSDYYQLQVGGPYQATGGMG
                     DTLAGMIAGFVGQFRQASLYERVAVATHLHSAIAQELSQENYVVLPTEISRYLPKIMK
                     IICQQERARKDKLV"
     gene            9844..10527
                     /gene="rpiA"
                     /locus_tag="VVO18_001166"
     CDS             9844..10527
                     /gene="rpiA"
                     /locus_tag="VVO18_001166"
                     /EC_number="5.3.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000429260.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-5-phosphate isomerase RpiA"
                     /protein_id="HEU5586334.1"
                     /translation="MENLKKMAGIKAAEFVSDGMVVGLGTGSTAYYFVEEIGRRIKEE
                     GLQITAVTTSSVTTKQAEGLNIPLKSIDQVDFVDVTVDGADEVDSQFNGIKGGGGALL
                     MEKVVATPSKEYIWVVDESKLVEKLGAFKLPVEVVQYGAEQVFRHFERAGYKPSFREK
                     DGQRFVTDMQNFIIDLALDVIENPIAFGQELDHVVGVVEHGLFNQMVDKVIVAGRDGV
                     QISTSKKGK"
     gene            10541..11752
                     /locus_tag="VVO18_001167"
     CDS             10541..11752
                     /locus_tag="VVO18_001167"
                     /EC_number="5.4.2.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259464.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopentomutase"
                     /protein_id="HEU5586335.1"
                     /translation="MSKFNRIHLVVLDSVGIGAAPDANNFVNAGVPDGASDTLGHISK
                     TVGLNVPNMAKIGLGNIPRETPLKTVAAESNPTGYATKLEEVSLGKDTMTGHWEIMGL
                     NITEPFDTFWNGFPEEILTKIEEFSGRKVIREANKPYSGTAVIDDFGPRQMETGELII
                     YTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFTRT
                     ANRRDLAVSPFSPTVLDKLNEAGIDTYAVGKINDIFNGAGINHDMGHNKSNSHGIDTL
                     LKTMGLAEFEKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMRENDLL
                     LITADHGNDPTYAGTDHTREYIPLLAYSPAFKGNGLIPVGHFADISATVADNFGVETA
                     MIGESFLDKLV"
     gene            11754..12296
                     /locus_tag="VVO18_001168"
     CDS             11754..12296
                     /locus_tag="VVO18_001168"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1697 domain-containing protein"
                     /protein_id="HEU5586336.1"
                     /translation="MTRYALLVRGINVGGKNKVVMAELRQELTNLGLEKVESYINSGN
                     IFFTSIDSKAQLVEKLGTFFAVHYPFIQSFSLLSLEDFEAELENLPAWWSRDLARKDF
                     LFYTEGLDVDQVIATVESLELKDEVLYFGKLGIFWGKFSEESYSKTAYQKYLLKVPFY
                     RHITIRNAKTFDKIGQMLKK"
     gene            12312..13121
                     /locus_tag="VVO18_001169"
     CDS             12312..13121
                     /locus_tag="VVO18_001169"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEU5586337.1"
                     /translation="MTFLNKIHETATFLKEKGIAAPEFGLILGSGLGELAEEIENPVV
                     VDYAEIPNWGRSTVVGHAGKLVYGELAGRKVLALQGRFHFYEGNPLEVVTFPVRVMKV
                     LGCEGVIVTNAAGGIRFGPGTLMAISDHINMTGQNPLMGENLDDFGPRFPDMSRAYTP
                     EYRATAHEVAKKLNIKLDEGVYIGVTGPTYETPAEIRSYKTLGADAVGMSTVPEVIVA
                     AHSGLKVLGISCITNFAAGFQEELNHEEVVEVTERVKGDFKGLLKAILAEL"
     gene            13597..13992
                     /locus_tag="VVO18_001170"
     CDS             13597..13992
                     /locus_tag="VVO18_001170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000887334.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="topology modulation protein"
                     /protein_id="HEU5586338.1"
                     /translation="MLDSKEELKESENDAPKLETPLREEPRLAPQTLPEASEVLENKR
                     EESKVEITEPAQADDIRKVVGELAKDISITKLYMTGHSLGGYLAQIAAVEDYQKYPDF
                     YNHVLRKVTTFSAPKVITSRTVWDAKNGF"
     gene            14002..14577
                     /locus_tag="VVO18_001171"
     CDS             14002..14577
                     /locus_tag="VVO18_001171"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000445853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="discoidin domain-containing protein"
                     /protein_id="HEU5586339.1"
                     /translation="MESRKLAVSGKIKHYVVDNDNVVTPLIHNNRDIVTFTGNSRFKH
                     RSRGYFESPMNDIPNFNIGKQATLDKHGYRDPKLDKVRFFKKQALPQSSSQPSAEPME
                     NIALGKQVTQSSTAFGGDARRAVDGKVDGNYGHNSVTHTNFQSKPWWQVDLAKEETIR
                     QINIYNRTDTAQDRLANFDVILLDSSGKEIE"
     gene            14602..15114
                     /locus_tag="VVO18_001172"
     CDS             14602..15114
                     /locus_tag="VVO18_001172"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001275913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin"
                     /protein_id="HEU5586340.1"
                     /translation="MSAQITINHKKARYVRIELEGYNALSLAEVEVFRFIATNAETAT
                     QVSKPVQPISQTPVKDKTLTIQHSGAYIARYSITWEEVPVDKDGNQVVRSHSWEGNGC
                     NQTAGFVLNLPIKENMRNLRVKIEKKTGLLWNRWQTIYENRPILAQPHRKITHWGTTL
                     NSKVSDDDVL"
     gene            15772..16482
                     /gene="deoD"
                     /locus_tag="VVO18_001173"
     CDS             15772..16482
                     /gene="deoD"
                     /locus_tag="VVO18_001173"
                     /EC_number="2.4.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007519526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="purine-nucleoside phosphorylase"
                     /protein_id="HEU5586341.1"
                     /translation="MSIHIAAQQGEIADKILLPGDPLRAKFIAENFLDDAVCFNEVRN
                     MFGYTGTYKGHCVSVMGTGMGMPSISIYARELIVDYGVKKLIRVGTAGSLNEEVHVRE
                     LVLAQAAATNSNIVRNDWPQYDFPQIASFDLLDKAYHIAKKLGMTTHVGNVLSSDVFY
                     SNYFEKNIELGKWGVKAVEMEAAALYYLAAQYHVDALAIMTISDSLVNPDEDTTAEER
                     QNTFTDMMKVGLETLIAE"
     gene            complement(16505..17029)
                     /locus_tag="VVO18_001174"
     CDS             complement(16505..17029)
                     /locus_tag="VVO18_001174"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topology modulation protein"
                     /protein_id="HEU5586342.1"
                     /translation="MKITIIGYSGSGKSTLAEKLSNYYSIPKLHMDTLQFQPGWQDSD
                     CEWMLTEIKNFLTKHKAWVIDGNYSWCYYQERMQEADQIIFLNFLPLTCLFRAFKRYL
                     KYRGKVRESMAADCPERFDWEFIRWILWDGRSKTQKENYQKLCQEYSHKVTILRNQRE
                     LDQFLDKKRKSYNS"
     gene            complement(17082..17318)
                     /locus_tag="VVO18_001175"
     CDS             complement(17082..17318)
                     /locus_tag="VVO18_001175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S20"
                     /protein_id="HEU5586343.1"
                     /translation="MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELF
                     RAASSAIDKAETKGLIHKNKASRDKARLSTKLAK"
     gene            complement(17386..18306)
                     /locus_tag="VVO18_001176"
     CDS             complement(17386..18306)
                     /locus_tag="VVO18_001176"
                     /EC_number="2.7.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261526.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pantothenate kinase"
                     /protein_id="HEU5586344.1"
                     /translation="MTNEFLHFEKISRQTWQSLHRKTTPPLTEEELESIKSFNDQISL
                     QDVTDIYLPLAHLIQIYKRTKEDLAFSKGIFLQRESKSQPFIIGVSGSVAVGKSTTSR
                     LLQILLSRTFTDATVELVTTDGFLYPNQTLIEQGILNRKGFPESYDMEALLNFLDRIK
                     NGQDVDIPVYSHEVYDIVPEKKQSVKAADFVIVEGINVFQNPQNDRLYITDFFDFSIY
                     VDAGVDDIESWYLDRFLKMLSLAQNDPDSYYYRFTQMPIGEVESFAHQVWISINLTNL
                     QNYIEPTRNRAEVILHKSKNHEIDEIYLKK"
     gene            18496..18899
                     /locus_tag="VVO18_001177"
                     /pseudo
     CDS             18496..18899
                     /locus_tag="VVO18_001177"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698118.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            19115..19696
                     /locus_tag="VVO18_001178"
     CDS             19115..19696
                     /locus_tag="VVO18_001178"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU5586345.1"
                     /translation="MYYAENPDAAHDIHELRVDLLGEKMTFLTDAGVFSKKMVDFGSQ
                     LLLKCLDVNQGETVLDVGCGYGPLGLSLVKVYGVQATMVDINTRALDLAQRNAEKNNA
                     KATIFQSNIYARVQGRFDHVISNPPIRAGKQVVHEIIEKSKDFLEIGGDLTIVIQKKQ
                     GAPSAKSKMEDVFGNCEILKKDKGYYILRSVKE"
     gene            19693..20970
                     /locus_tag="VVO18_001179"
     CDS             19693..20970
                     /locus_tag="VVO18_001179"
                     /EC_number="2.4.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001202959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyrimidine-nucleoside phosphorylase"
                     /protein_id="HEU5586346.1"
                     /translation="MRAVDLIQKKRDGQELTSSEIEWLIEGYVSGTVPDYQMSAFAMA
                     VYFKGMTTREISDLTMNMVKTGQEFDLSAIDGVKVDKHSTGGVGDKVTLILAPLVASF
                     GVPVAKMSGRGLGHTGGTIDKLESIKGYQVERSQEDFIRQVQDIGVSVIGQSDQLVKA
                     DKLLYALRDVTATVDTIPLIASSVMSKKIAAGADAILLDVTVGEGAFMKTVDEARELA
                     QTMVDLGKVVGRKTVAVITDMSQPLGRAIGNRLEILEALEILQGQGRQDITHFICELA
                     QIMLGLANVNKTVEEVRQHLENGQALAKFEEMVQAQGGDLEDLYRPVNVAHVVEIPAQ
                     ETGVISALPAMDFGLYAMRLGAGRAVKSDVLDYETGIVFEKKIGDSVQKGEIVAKVYT
                     NEKIPPQLVTDFQKCVKISDEVKKIREIVEIIS"
     gene            20988..21650
                     /gene="deoC"
                     /locus_tag="VVO18_001180"
     CDS             20988..21650
                     /gene="deoC"
                     /locus_tag="VVO18_001180"
                     /EC_number="4.1.2.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773666.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="HEU5586347.1"
                     /translation="MKLNKYIDHTLLKQDAKKKQIDSLLSEAREYDFASVCVNPTWVE
                     HAKKGLEGTDVKVCTVVGFPLGATTSAVKAFETKEAIQNGADEIDMVINVGALKSGNL
                     ALVESDIRAVVEASGDKLVKVIIEACLLTDQEKIVVCQLAQKAGADFVKTSTGFSTGG
                     ATIADVRLMRETVGSDMGVKAAGGARSYADALAFVEAGATRIGTSAGVAILKGELADG
                     DY"
     gene            21637..22026
                     /locus_tag="VVO18_001181"
     CDS             21637..22026
                     /locus_tag="VVO18_001181"
                     /EC_number="3.5.4.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytidine deaminase"
                     /protein_id="HEU5586348.1"
                     /translation="MATTELIELAIETSKHAYVPYSHFPIGAVLVAKDGSVYTGVNIE
                     NASYPLTNCGERTAVFKAISEGQREFSELIVYGQTEKPILPCGACRQVMVEFFEQDLK
                     VTLVAKDKSTVEMTVGELLPYSFTDLN"
     gene            22117..23169
                     /locus_tag="VVO18_001182"
     CDS             22117..23169
                     /locus_tag="VVO18_001182"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BMP family protein"
                     /protein_id="HEU5586349.1"
                     /translation="MNKKQWLGLGLVAVAAVGLAACGNRSSRNAASSSDVKTKAAIVT
                     DTGGVDDKSFNQSAWEGLQDWGKEHNLSKDNGFTYFQSTSEADYANNLQQAAGSYNLI
                     FGVGFALHNAVEEAAKEHTDLNYVLIDDVIKDQKNVASVTFADNESGYLAGVAAAKTT
                     KTKQVGFVGGIESEVISRFEAGFKAGVASVDPSIKVQVDYAGSFGDAAKGKTIAAAQY
                     AAGADIVYQVAGGTGAGVFAEAKSLNESRPENEKVWVIGVDRDQEAEGKYTSKDGKES
                     NFVLVSTLKQVGTTVKDISNKAEKGEFPGGQVIVYSLKDKGVDLAVTNLSEEGKKAVE
                     DAKAKILDGSVKVPEK"
     gene            23313..24848
                     /locus_tag="VVO18_001183"
     CDS             23313..24848
                     /locus_tag="VVO18_001183"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000929819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586350.1"
                     /translation="MAHENAIEMRDITKVFGGFVANDKINLHLRKGEIHALLGENGAG
                     KSTLMNMLAGLLEPTSGEIAVNGQVVNLDSPSKAASLGIGMVHQHFMLVEAFTVAENI
                     ILGSELTKNGVLDIAGASKEIKALSERYGLAVDPSAKVADISVGAQQRVEILKTLYRG
                     ADILIFDEPTAVLTPSEIDELMAIMKNLVKEGKSIILITHKLDEIRAVSDRVTVIRRG
                     KSIETVEIAGATNADLAEMMVGRSVSFKTEKQASKPKEVVLSIKDLVVNENRGVPAVK
                     NLSLDVRAGEIVGIAGIDGNGQSELIQAITGLRKVESGSIELKGDSIVGLHPRQITEL
                     SVGHVPEDRHRDGLILEMMISENIALQTYYKEPHSKNGILNYSNITSYAKKLMEEFDV
                     RAASELVPAAALSGGNQQKAIIAREIDRDPDLLIVSQPTRGLDVGAIEYIHKRLIEER
                     DNGKAVLVVSFELDEILNVSDRIAVIHDGKIQGIVSPETTNKQELGVLMAGGNLGKEK
                     SDV"
     gene            24841..25899
                     /locus_tag="VVO18_001184"
     CDS             24841..25899
                     /locus_tag="VVO18_001184"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586351.1"
                     /translation="MSKKLQQISVPLISVFLGILLGAIVMWIFGYDAIWGYEELFYTA
                     FGSLRGIGEIFRAMGPLVLIGLGFAVASRAGFFNVGLPGQALAGWILSGWFALSHPDM
                     PRPLMILATIVIALIAGGIVGAIPGILRAYLGTSEVIVTIMMNYIVLYVGNAFIHAFP
                     KDFMQSTDSTIRVGANATYQTPWLAELTGNSRMNIGIFFAIIAVAVIWFMLKKTTLGF
                     EIRAVGLNPHASEYAGISAKRTIILSMIISGALAGLGGAVEGLGTFQNVYVQGSSLAI
                     GFNGMAVSLLAANSPIGILFAAFLFGVLQVGAPGMNAAQVPSELVSIVTASIIFFVSV
                     HYLIERFVKPKKQVKGGK"
     gene            25902..26858
                     /locus_tag="VVO18_001185"
     CDS             25902..26858
                     /locus_tag="VVO18_001185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586352.1"
                     /translation="MSIITLLPLLVSSMLIYSAPLIFTSIGGVFSERGGVVNVGLEGI
                     MVMGAFSGVVFNLEFAEQFGAATPWLSLLVAGLVGSVFSIIHAAATVHFRADHVVSGT
                     VLNLMAPALAVFLVKVLYNKGQTDNLSQTFGRFDFPVLANIPVIGDIFFKSTSLLGYL
                     AIAFSFLAWFILFKTQFGLRLRSVGEHPQAADTLGINVYKMRYLGIIISGFLGGIGGA
                     IYAQSISVNFSVTTIVGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGSQLPF
                     LQGVPAVYLQIAPYVLTILVLAAFFGKAVAPKADGINYIKSK"
BASE COUNT         7969 a         4845 c         6011 g         8127 t
ORIGIN      
        1 tctcttgaat actgtctccc aagtcgtacg atacttctta actggctagc acaatacagg
       61 aaaaacgggt atactattgt tgagaaaaca agagggagag tacctgagag cggaaaatgc
      121 catcctaaaa aagttaagag aactccgatt gaaggaggaa aaagagaaag aagaaagaca
      181 gaaattgttc aagaattaat gactgagttt tcgttagata ttcttctaaa agccattaaa
      241 ctagctcgtt cgacctacta ctatcacttg aaacagctag ataaaacaga taaggaccaa
      301 gagcttaaag ctgaaattca atccattttt atcgaacaca agggaaatta tgcttatcgt
      361 cggatttatt tagaactaag aaatcgtggt tatctggtaa atcataaaag agttcaaggc
      421 ttgataaaag tactcaattt acaagctaaa atgcgacaaa aacgaaaata ttcttctcat
      481 aaaggagacg ttggtaagaa agcagagaat ctcattcaag gccaatttga aggctctaaa
      541 acaatggaaa agtgctacac agatgtgaca gaatttgcca ttccagcaag tactcaaaag
      601 ctttacttat taccagtttt agatggcttt aatagcgaaa ttatcgccta taatctttca
      661 acttcaccca acttagaaca agtacaaaca atgttggaac aggcattcaa agagaagcac
      721 tacgagaata cgattctcca tagtgaccaa ggctggcaat atcaacacga ttcttatcat
      781 cagtttcttg agggtaaggg aattcaagca tccatgtcac gtaagggtaa cagcccagac
      841 aatggtatga tggagtcctt ctttgggatt ctgaaatcgg aaatgtttta cggttatgag
      901 aagtcgtttc agtcgcttaa gcaattggaa caagccattg tagactatat tgattactac
      961 aacaataaac gaattaaggt aaaactaaaa ggacttagcc ctgtgcaata cagaactaaa
     1021 tccttcggat aaattaattg tctaactttt tggggtcagt acaaaactct tgctactatg
     1081 cgttttatta ttgaaagact tattggactt tctctcaaat cgagttttta ctcaattttc
     1141 ttacttgatt gggattgaaa ttccaattaa tttctctgag tagagtgtct tgatattggc
     1201 ttcatcaaca gaggccttat caattttacg tttcaagaaa aattcttgaa tggtttcgat
     1261 ttcaggctca cgaatagcac ggtgtttgtt tgagatgagg atttcatagt gaagcggagc
     1321 ttgggtaaaa ataacatctg tattccctgc agaataaacc tcaacaaggg ttgcatcggt
     1381 actttctagt tgacttttta caagttgcga gtgtgagttt gtcgtattga taagcttcat
     1441 aatatttcct ccgattttct aattctatta tagcactttt tgaataaagt cgcttgattt
     1501 atactcaatg aaaatcaaag agcaaactag gaagctagcc gcaggctata cttgagtacg
     1561 gtaaggcgac gctgacgtgg tttgaatttt attttcgaag agtattagcc aatcttatgc
     1621 tgttttttcc aagattcaat ggcccattta tggctaccac gtttaaggtt ttggatagcc
     1681 tcgtcaatag ggaaccaggc aatatgatta aagttttcta gtggcttttg tacttctttg
     1741 aaagaagttg cttcatagag gtaggcagga ttgtagtagt aggtatcacg atgacgagaa
     1801 tagaaatatt cgtcagtttg tccgtaatag gtaccaattt ctgctgtgaa accaagctct
     1861 tcaatcaact cacgctttag ggcttcctga tgattttcac ctgcttcaat ttctccacat
     1921 ggtaggaacc aagcaccatt tggttcttga acaagaacaa tttgtttttg ttcaggatta
     1981 gggataactg catatacgcc atagcgagca atatagtctg tattcgcttt ttttctccga
     2041 gagttgggtt tgccattgca ttttcctcat tatctagtat cgttattatt atagtaaaat
     2101 gaaccaaaaa tagtacacaa tgtggtataa tcttcttatg gcatattcaa tagattttcg
     2161 taaaaaagtt ctctcttatt gtgagcgaac aggtagtata acagaagcat cacacgtttt
     2221 ccaaatctca cgtaatacca tttatggctg gttaaagcta aaagagaaaa caggagagct
     2281 aaaccaccaa gtaaaaggaa caaaaccaag aaaggttgat agagatagac ttaaaaacta
     2341 tcttactgac aatccagatg cttatttgac tgaaatagct tctgaatttg gctgtcatcc
     2401 aactaccatc cactatgcgc tcaaagctat gggctacact cgaaaaaaag aaccacacct
     2461 actatgaaca agacccagaa aaagtagcca tatttcttaa gaattttaat agattaaagc
     2521 acctagcacc tgtttagatt gacgaaacag gattcgatac ttatttttat cgagaatatg
     2581 gtcgctcatt aaaaggtcag ttaataagag gtaaagtatc tggaagaaga tatcagagga
     2641 tttctttggt tgcaggtcta acaaatggtg agttaatcgc tccaatgact tacgaagaga
     2701 tgatgacgag cgactttttt gaagcttggt ttcagaagtt tttcttacca acattaacca
     2761 caccatcggt tattattatg gataatgtaa gattccatag aatggggaag aatgtaagat
     2821 tccatagaat ggggaagcta gaacttttat gcgaagagtt tgggcataaa cttttacctc
     2881 ttcctcccta ctcgcctgag tacaatccta ttgagaaaac atgggctcat atcaaaaagc
     2941 acctcaaaaa ggtattacca agttgcaata ccttttacga ggctcttttg tcctgttctt
     3001 gtttcaattg actatagcag attgaaatga gaacaaatcg attgggaaag taaaattaat
     3061 ttctataaat gttttagcaa ttgtttcgta ctatttcaga ttcagtctac tatatatcat
     3121 aatggacaaa gggcaagctg tcaagaaatt acagttattt tagtaaaaaa agaagcagaa
     3181 aaatttcatt ttctactcct tttctatagg atttattttt ctttttcaga acttttaact
     3241 tcagcttttt tggcagattt aatctgaatg tttcccttgc tagtcataac tgctttgaga
     3301 tctttttcgc ttggattttc aaggtagtag tcagtgattg tgtcctcaat atagtcttga
     3361 atagtccgac gaagtgggcg tgctcccatt tttggatcat aacctaggtc aaccaacttt
     3421 tccttgacct tatcagttac atccaaacga atgttgttgc tagagaggcg cttgttaaca
     3481 tctgctagca tgagctcgac aatctgaagg aggttatcct tgctgagagc cttaaattcg
     3541 ataatgccat caaaacggtt cataaactct gggctaaaga agttaccgag ttcaccgagg
     3601 acagaattgg tacgtccttc tctagcagca ccaaatccaa cgctagcttc ggtctttcct
     3661 gtacctgcat ttgaggtcat gataatgatg gcatccttga agctaacggt gcgtccttgc
     3721 ccgtctgtca aacgaccatc gtccaagact tgaagaaaca tgtgcataac atctgggtga
     3781 gctttttcca cttcatcgag aaggatgaga gaatatggat tgtggcgaac tttttcagtt
     3841 aattgaccag cctcatcata gccaacataa cctggagggg cgccgaccaa cttagccaca
     3901 ctatgttttt ccatgtattc actcatatca aagcgaatca tactatcagc agaaccaaaa
     3961 agttcgatag ccagttgttt ggaaagttct gtcttaccga caccagttgg cccaacgaag
     4021 aggaagcttc cgattgggcg gttaggggta ccaagtccga cacgattacg gcgaatagcc
     4081 ttggcaatct tatcgactgc atcatcttgg ccaataacat gagacttgag atcttcggct
     4141 agatggatga gttgagattg ttctttctct ttcaaatcac caacagggat attggttttc
     4201 tgctcgataa tgtgctcaat agttttctcg ctgatgatag gagtatcctg gtctgtgatc
     4261 tttttctttt gcatttcctt atacttggca atctggtcgc ggaagtaggc cgccttctca
     4321 aaatcttctt ctcgtgtagc ttgagacttg agattttcag cctcaatcaa gcgctgatca
     4381 attactttag gatccacaaa attcaaggtc aagttcatct tagaaccagc ttcatctagg
     4441 aggtcaatgg ccttgtcagg caagaagcga tcttggatgt agcgattgga aagagttgca
     4501 gctgcttcaa tcgcagcatc tgtatattga acgtggtggt aatcttcgta tttcttttga
     4561 atccctttga gaatagtgat tgtttcgtcc accgttggtt catcgacttt aacaggctgc
     4621 atacgacgct cgagggcagc atccttttca atgatacggt attcattgag ggtagtagca
     4681 ccgactagtt gcagttctcc acgagcaagg gctggcttga ggatatttcc tgcgtccata
     4741 ttaccatcac tcgcagaacc agcaccaaca atttcatgga tttcatcgat aaagaggatg
     4801 atgtcttcac gtttgcgaat ttcttccatg agtttttgca tgcgttcttc aaattgtcct
     4861 cgaatccccg ttccttgaac taagctaacc acatccagac ggatgacttg tttaccttgg
     4921 agtttatgtg gcacatcgcc atcgacaatt ttctgagcta gaccttcgac aacggccgtt
     4981 tttcctacac caggttcacc gataaggaca ggattattct tggttctacg attgagaatc
     5041 tcgatgacac ggataatctc atcgtcgcgc ccaataacgg ggtcaatgtc tccacgacgg
     5101 gcaatttcag ttacattaat accaaattct tccagcaggc ctttttcttg gctaggtggc
     5161 ggagtttgag cagatccacg attttgggaa ccataaccgc cgtttccacc gtaacctcca
     5221 cctgattggg ttgggggaat aggcggagta ttgctagaag gtctgaaatt gtttagatca
     5281 ttgaagaaat caccaaaggg atcgaagtca cgattgttca gatccgtcat acctttgaag
     5341 aggctattgt taggatctgt tttgataatc ttatagcagt tttgacagag gtcaatttgt
     5401 ttttgttttc cattgagatt ggtgtaaaga tgaattgttg agtcgttaat tttacagttt
     5461 tgacaaagca tacatctacc tcatttcttt ctttagcctg acttgtttaa aggtcaaaaa
     5521 tagtcaaatt ctatactctc attataacag gattggggtg taaagcaagt aaaaagattg
     5581 aagctttgag aagttgttac aatgaaaatt tttgtgaatt tggactataa aaaaatccta
     5641 tttgtgagac aaaaaggatt ttacttagac atgcagggac aatcccagct tgttttagat
     5701 tagtagagaa gttcgtaaat ttccattgcg attaagtcaa tgctatcaaa cgtatacgtt
     5761 tcgcgatctt ctacgtcacg aagggtaaag attgggccgt tttcttcgtc gtggctgtac
     5821 gcaacttctg caacaacaac tccttcgcgt tcaaaattac gttttaaatt tccgccatcg
     5881 tttgccattg cttcaaggcg gttgatgatt ctaaccaaat gtgattccat tttgattctc
     5941 cttcatttct tatcgttact attttaccat aaaggaggcc aacttgacta gaaaaaacta
     6001 agatttctcg ctaattctgc tagtttaaag atttttaaat aaattggata aaaaatttaa
     6061 attttaattc aaaacatgtt ataatcatac agtattctat tttagaaagc agtgtgacta
     6121 tgaatttttc ttttttacct aagtatttac cttattttaa ctatggggct gttgtgacga
     6181 ttcttatttc tatctgtgtt atctttttgg gaactatttt gggtgttgtc ttggcttttg
     6241 ggcaacgttc aaagtttaaa ccgcttgttt ggttggccaa cttgtacgtt tggattttcc
     6301 gtgggacacc gatgatggtt caaattatga ttgcctttgc tcttatgcat atcaatgctc
     6361 cgactattca gattggaatt ttaggtgttg atttttcgcg tctgattcca gggattttga
     6421 ttatctctat gaatagtggt gcttatgttt cggagactgt tcgtgccgga atcaatgcgg
     6481 ttccaaaagg tcagctagag gcggcttatt cgctagggat tcgtcctaaa aatgcgatgc
     6541 gttatgtgat tttgccacaa gcagtcaaaa atatcttgcc agcattgggg aacgaattta
     6601 tcaccattat caaggacagc tccctcttat cagctattgg ggtcatggag ttgtggaatg
     6661 gggctacaac agtttctaca acaacctatc tacctttaac accgctttta tttgcagcat
     6721 tttattactt gattatgacc tctattctga cagtagcctt gaaagctttt gaaaaacata
     6781 tgggacaagg agataagaaa taatgacaga aaccttgata aaaattgaaa atttacataa
     6841 atcttttgga aagaatgaag tattgaaggg aatcaacctc gagattaaaa gaggagaagt
     6901 tgtcgttatc atcggtcctt cagggagtgg gaaatctacc ttgcttcgct ctatgaattt
     6961 gttggaggaa gcaaccaagg ggaaggttat ctttgaggga gtcgatatta cggacaagaa
     7021 gaatgacttg tttgccatgc gtgagaagat gggcatggtt ttccaacaat ttaacctctt
     7081 tcctaatatg actgtgatgg aaaatattac cttgtcacct atcaagacta aaggtgaaag
     7141 cagggaagtt gctgagaaga gagcccaaga gcttttggaa aaagttggtt tgccagataa
     7201 ggcagacgct tatccacaga gtctgtcggg tgggcaacaa caacggattg ccatcgcgcg
     7261 tgggttggct atggaaccag atgttttgct ctttgacgaa ccaacttcag ccttggatcc
     7321 tgaaatggta ggtgaggtat tggctgttat gcaagacctt gccaagtcag ggatgactat
     7381 ggttatcgta acacatgaga tgggatttgc ccgtgaggtg gcagatcgtg ttatctttat
     7441 ggcagacggt gtggttgttg aagatgggac acctgagcaa atttttgaac aaacccaaga
     7501 acaacggact aaagatttct tgagtaaggt tttataatct attttaaaat ttcaagacaa
     7561 gattagtgaa aagttcaacc agagcttttt cttatagttt gaaactatag gataacctag
     7621 gaaagaagtg ttagagggca ctagcagttt ttggtataat ggaagatatt tgaaagaaaa
     7681 gagaagtgat atgacacaga ttattgatgg gaaagcttta gcggccaaat tgcaggggca
     7741 gttggctgaa aagactgcaa aattaaagga agaaacagct ctagtgcctg gtttggtagt
     7801 gattttggtt ggggataatc cagccagcca agtctacgtt cgcaacaagg agaggtcagc
     7861 tcttgcggct ggttcccgta gcgaagtagt gcgagttcca gagaccatta ctcaagagga
     7921 attgttagac ctgattgcta aatataatca ggatccagct tggcatggga ttttggtcca
     7981 gttgccatta ccaaaacata tcgatgaaga ggcggtttta ttagccattg acccagaaaa
     8041 ggatgtggat ggtttccatc ccctaaacat gggacgtctt tggtctggac atccagtcat
     8101 gattccctcg acacctgcag gaattatgga aatgtttcat gaatatggga ttgacttgga
     8161 aggtaaaaat gcggtcgtaa tcggtcgttc aaatatcgtt ggaaaaccta tggctcagct
     8221 tcttttggct aaaaatgcga cagtaacctt ggcccactca cgaactcata atcttgccaa
     8281 ggtggctgct aaagcagata ttcttgtagt cgcaatcggc cgcgccaagt ttgtgactgc
     8341 tgactttgtc aaaccaggtg cggttgtcat tgacgttggg atgaatcgag atgaaaatgg
     8401 gaagctctgt ggagatgttg attatgaggc agttgcacca cttgctagcc atatcactcc
     8461 agtccctgga ggtgtcggtc ctatgaccat taccatgctg atggagcaaa cttatcaagc
     8521 agcacttcgg acattggata gaaaataaga gaaacattcg attaatagag tgtattttct
     8581 atagctatat ctaaaatggt agaaatgaat attaaatttt agatataaga ttacaaaagg
     8641 aggtctgcgt ctccttttta ttgtataata aaagtgagag gaaaaaagga tgaaagtgat
     8701 taatcaaacc ttattagaaa aagttattat tgaacgttct cgttcaagtc ataaaggaga
     8761 ttatggtcgt ctgctgctgc ttggtggtac ttatccttat ggaggtgcca tcatcatggc
     8821 tgctttagca gctgtaaaaa gcggtgcagg attggtgacc gttggaacgg acagggaaaa
     8881 tatcctggct ctgcacagcc atttacctga gcctatggcc ttttctcttc aagaccagca
     8941 attgttaaaa gagcaattgg agaaggcaga agttgtcttg ctggggcctg gtttacgaga
     9001 cgatgcttct ggagaaaatc tagtaaaaca ggtctttgtt aatttaagcc aaaatcagat
     9061 tttgattgta gacggaggtg ccttgaccat tcttgctagg acaagtttgt catttccctc
     9121 aagccagctt atcctaactc ctcaccaaaa agaatgggaa aaattatctg gaattacgat
     9181 tgaaaagcaa aaggaagatg caacggctag tgttctgact tccttccctc aaggaacaat
     9241 tttggtggag aaaggcccag ctactcgtat ttgggaagtt ggccaatctg attattacca
     9301 gttacaggtt ggtggtcctt atcaggcgac tgggggaatg ggagatactc tggctgggat
     9361 gatcgcagga tttgtaggcc aattccgaca ggccagtctc tacgagcgtg tggcagtagc
     9421 gacccatctt cattcagcca tagcccaaga actatctcaa gaaaattatg tggtcttacc
     9481 gacggaaatc agcaggtatc ttcccaaaat aatgaaaatt atttgtcaac aagagagggc
     9541 aagaaaagat aaacttgttt aaaatagaca gataaatcta cttccttctc ttaatttatg
     9601 attcttgaaa tgcgcctgct ttaaggctaa actagacgta tcaaagttaa gagtttgttt
     9661 ttgtaactgg aaagagatga acaaatcaaa tacataaaag ataaactcat ttttatttgt
     9721 ttggtaaaaa taaaatgcat atttttaaag aaagattgat gaaaaatgta gatttgatgt
     9781 ttttacttga ataaaaagcg gtttcatagt aaaataagaa ctgagaatga tggaggtaaa
     9841 tcggtggaaa atctgaagaa aatggcaggt atcaaggctg ctgagttcgt gagcgatgga
     9901 atggtcgttg gacttggaac aggctcgact gcctattatt ttgtcgaaga aatcggtcgt
     9961 cgtatcaagg aagaaggatt gcagattaca gctgtaacaa cttctagtgt gaccactaaa
    10021 caggcagaag gccttaatat cccgctcaag tctattgacc aagtagactt tgtcgatgtg
    10081 acggttgatg gcgcggatga agtggatagt cagtttaatg gaatcaaagg cggtggtggt
    10141 gcccttctca tggaaaaggt ggtcgcaaca ccatcaaaag aatacatttg ggtggtggat
    10201 gaaagcaagc tggtcgaaaa actaggtgct tttaaattgc cagtagaagt ggttcagtat
    10261 ggtgcagagc aggtctttcg tcattttgaa cgagctggct acaaaccaag tttccgtgaa
    10321 aaagacggcc aacgttttgt gacggatatg cagaatttta tcattgacct cgccttggat
    10381 gtcattgaaa atccaattgc ttttggacaa gaattggatc atgtcgttgg tgttgtggag
    10441 catggtttat tcaaccaaat ggtggataag gtaatcgttg ctggacggga tggagttcag
    10501 atttcaactt caaaaaaagg aaaatagaag ggggcataag atgtctaaat ttaatcgtat
    10561 tcatttggtg gtactggatt ctgtaggaat cggtgcagca ccagatgcta ataactttgt
    10621 caatgcaggg gttccagatg gagcttctga cacactggga catatttcaa aaacagttgg
    10681 tttgaatgtc ccaaacatgg ctaaaatagg tcttggaaat attcctcgtg aaactcctct
    10741 taagactgta gcagctgaaa gcaatccaac tggatatgca acaaaattag aggaagtatc
    10801 tcttggtaag gatactatga ctggacactg ggaaatcatg ggactcaaca ttactgagcc
    10861 tttcgatact ttctggaacg gattcccaga agaaatcctg acaaaaatcg aagaattctc
    10921 aggacgcaag gttattcgtg aagccaacaa accttattca ggaacggctg ttatcgatga
    10981 ttttggacca cgtcagatgg aaactggaga gttgattatc tatacttcag ctgaccctgt
    11041 tttgcagatt gctgcccacg aagacattat tcctttggat gaattgtacc gtatctgtga
    11101 atacgctcgt tcgattaccc ttgagcgtcc tgcccttctt ggtcgcatca ttgctcgccc
    11161 ttatgtaggt gaaccaggta acttcactcg tacggcaaac cgtcgtgact tggctgtatc
    11221 tccattttcc ccaactgttt tggataaatt gaatgaggct ggtatcgata cttatgctgt
    11281 gggtaaaatc aacgatatct ttaacggtgc tggtatcaac catgacatgg gtcacaacaa
    11341 gtcaaatagt catggaattg atacactatt gaagactatg ggacttgctg agtttgaaaa
    11401 aggattctca ttcacaaacc tagttgactt tgatgccctt tacggccatc gtcgtaatgc
    11461 tcacggttac cgtgattgct tgcatgagtt tgatgaacgc ttacctgaaa ttatcgcagc
    11521 tatgagagag aatgaccttc tcttgattac tgcggaccat ggaaatgacc caacgtatgc
    11581 aggaacggat cacactcggg aatatattcc attgttggca tatagccctg cctttaaagg
    11641 aaatggtctc attccagtag gacattttgc agatatttca gcgactgttg ccgataactt
    11701 tggtgtggaa actgctatga ttggggaaag tttcttagat aaattggtat aatatgacgc
    11761 gctatgcttt gctggtgaga ggtatcaatg ttggtggtaa gaataaggtc gtcatggcgg
    11821 agcttcgtca agaattgaca aacttgggac tggaaaaggt tgagagctac atcaacagtg
    11881 gcaatatttt ctttacttcg atagattcca aagcccaatt ggttgaaaag ctagggactt
    11941 tctttgcagt ccattatcca tttattcaga gcttttcttt actgagtcta gaggactttg
    12001 aggcggaact tgaaaatcta ccagcttggt ggagcagaga cttggcacga aaagattttc
    12061 tcttttacac tgagggtttg gatgtggacc aagtcatcgc gacagttgaa agtttagagc
    12121 tgaaagatga agtgctttat tttggaaaac ttgggatttt ctgggggaaa ttttctgaag
    12181 aatcctattc taagactgcc tatcagaagt acttgctgaa ggtgcctttc taccgccaca
    12241 ttactattcg taatgctaaa acctttgaca aaattggtca aatgctaaaa aaataataaa
    12301 ggagacacac aatgacattt ttaaacaaaa tccatgaaac tgctactttc ctgaaagaaa
    12361 agggaattgc agcccctgag ttcggtctaa tccttggatc aggacttgga gaattggcag
    12421 aagaaatcga aaatccagtt gtagtagact atgctgagat tccaaactgg ggccgttcaa
    12481 cagtagtcgg tcatgctggt aaattggtat atggtgaact ggcaggtcgc aaggtcttgg
    12541 ctcttcaagg tcgtttccat ttctatgaag ggaatcctct ggaagtggtg actttcccag
    12601 ttcgtgtgat gaaagttctt ggatgtgaag gtgttattgt aaccaatgca gctggcggta
    12661 tcagatttgg tcctggtacc ttgatggcta tctcagacca tatcaacatg acggggcaaa
    12721 atccattgat gggtgaaaac ttggatgact ttggcccacg tttcccagat atgtctaggg
    12781 cctacacacc agaataccgt gccactgccc atgaagtggc taaaaaactt aatatcaagc
    12841 ttgatgaagg tgtctatatc ggagttactg gtccgactta tgaaacacca gcagaaattc
    12901 gttcctataa gacactggga gcagatgcag ttggtatgtc tacggttcct gaagttatcg
    12961 tggcagccca ctctggcttg aaagttctgg gaatttcatg tatcactaac tttgcggctg
    13021 gtttccaaga agaactcaat cacgaagaag ttgtagaagt gactgaacgt gttaaaggtg
    13081 atttcaaagg cttgcttaaa gcgattcttg ctgaattgta agaaaaaaga tttaaaaggg
    13141 gtagtgtctc tgtcttttca ggattgactg cctatccgta ttaaagaaga aacagaggaa
    13201 tactatgagc ttcttcctgc tcttataact gaaagaagcg gaagaatagg tatgtctgat
    13261 ctgatagcca gcattgtgaa agacaagatt ctaggatact agcattagct ttctagccaa
    13321 gcagactagt atgataagga gagatgagaa tgaattgact ttctgaattt ctcagtctta
    13381 tcatatatag cacaatgaga tttcgcttga gtctgcttgt aaataaacga aaagaaagat
    13441 aataaataat gaaaattggt caacgaatta tgcgctttgg cataaaaaat taagtatcgg
    13501 agttgtatct gttgtagtcg gctttgattt ctagctccag ctggaatttc agccaatgaa
    13561 gtaaagcaag atgtaacatc tgaagtggta ataggtgtgc tagattctaa ggaggaattg
    13621 aaagagtcag aaaatgatgc tccaaaacta gaaactcctc ttagagagga gccaagacta
    13681 gctcctcaaa cgcttccgga agcaagtgaa gttcttgaaa acaaaaggga agagtcaaaa
    13741 gtagagataa cagagccagc tcaagcggat gatatccgca aggttgttgg ggaattagcc
    13801 aaggatataa gtattactaa gttgtatatg acaggtcatt ctcttggagg ctacctagct
    13861 cagattgcag cggttgaaga ttaccaaaaa tatcctgatt tttataacca tgtattgagg
    13921 aaagtgacaa ctttcagtgc tcctaaagtc attacttcca gaactgtttg ggatgctaag
    13981 aatggtttct gagatgttgg tttggaaagt cgtaaattag ctgttagtgg aaaaattaag
    14041 cattatgtgg ttgataatga caatgttgtg actcccttga ttcataataa tcgtgatatt
    14101 gttacattta caggtaattc acgctttaaa caccgttctc gtggctattt tgaaagtcca
    14161 atgaatgata ttcctaactt taatattggt aaacaagcta ccttggataa acatggttat
    14221 cgtgatccga aattggataa agtgcgattc tttaagaaac aggctctacc tcaatcttct
    14281 agtcaaccaa gcgctgaacc aatggaaaat attgccttag gaaaacaggt tactcaaagt
    14341 tcgacagctt tcggaggaga tgctagaaga gctgtggatg gcaaagtcga tggtaactat
    14401 ggtcacaatt ctgtcactca tacaaacttc caatctaagc cttggtggca agtagatttg
    14461 gctaaagaag aaaccattcg ccaaatcaat atttacaacc gaacagacac tgcccaggat
    14521 agattggcaa actttgatgt cattctttta gacagttctg gtaaagaaat tgagtgaaaa
    14581 cgtataatat ctcctaaaga tgtgtcagca caaattacga ttaaccataa aaaagcgcgc
    14641 tatgttcgga ttgagctaga aggctataat gccctcagtc ttgcagaagt tgaagttttc
    14701 cgctttatag ctacgaatgc tgaaacggcg acacaagttt ctaagccagt tcaaccaatc
    14761 agtcagactc ctgtgaaaga taaaacattg acaattcaac acagtggagc ttacattgcc
    14821 cgctactcca taacttggga agaagttcca gtagataaag atggaaacca agttgttcgt
    14881 agtcattctt gggaaggaaa cggttgcaac cagactgcag gttttgtcct caacctccca
    14941 atcaaagaaa atatgagaaa tctgcgagtt aagattgaga aaaagacggg cctactatgg
    15001 aatagatggc aaacaatcta tgaaaacaga ccaattttag ctcaacccca ccgtaaaatt
    15061 acccattggg gtacgacatt gaattccaag gtgagtgacg atgatgtctt gtaatctgat
    15121 ggtagaatga cagttagttt gtctagttta taagaaagta ctacctgagc ttgaatagaa
    15181 ctcaggtagc tctctatgaa agaacaaaat taatactcaa tgaaaatcaa agagcaaact
    15241 aggaaactag ccgcaggttg ctcaaagcac tgctttgagg ttgtagataa gactgacgaa
    15301 gtcagtcaca tatataatcc aaggcgacgt tgacgtggtt tgaagagatt ttcgaagagt
    15361 ataaacagaa aggtagagcg cgtgttctaa tttgaacacg agtagaaaac ttttctaaaa
    15421 acaaaaacga aaggatgggt aaactgtatt cgctgaactg aatacgggcg actctcctct
    15481 aaatcaaaat taagaaagaa aggaattgcc cccaccctaa aagcagtggg aaaaagatag
    15541 ttgatctagc gagcatcgct cactgcgccc aactcctatt ttcccttcgc tttttgatgg
    15601 gtttggtatc tttctcaata taaaatataa aataaagaaa ggtagagcgt gtgttttgat
    15661 ttgaacacga gcggaaaact cggaaaatag ataatctgac tgaaaaatca ggatttctcg
    15721 tcaggttcct aattttcagt cgttttcttc tcgctctttg tatcataaat tatgtctatc
    15781 catattgctg ctcagcaggg tgaaattgct gataaaattc ttcttcctgg ggatcctctt
    15841 cgtgctaagt ttattgcgga gaatttcctt gatgatgctg tttgttttaa cgaagtgcgt
    15901 aacatgtttg gttacactgg tacttacaag ggtcactgtg tatctgtcat gggaactggg
    15961 atgggaatgc catctatttc gatttatgcg cgtgagttaa tcgtagacta cggtgtgaag
    16021 aaattgattc gtgtgggaac tgcaggttct ttgaatgaag aggttcatgt tcgtgaatta
    16081 gttttggcgc aggcggctgc aaccaactca aacatcgttc gtaatgactg gccacagtac
    16141 gattttccac aaattgctag ctttgatttg cttgataaag cctaccatat cgccaaaaaa
    16201 cttggtatga ctactcacgt tgggaacgtt ttgtcatctg atgtctttta ctcaaattac
    16261 tttgaaaaga atatcgagct tggtaaatgg ggagtcaagg ctgtggaaat ggaagcagca
    16321 gctctttact atcttgctgc ccaataccat gttgatgcgc tagctatcat gaccatctct
    16381 gatagcttgg tcaatccaga cgaagacaca actgcagaag aacgtcaaaa taccttcact
    16441 gatatgatga aggttggttt ggaaaccttg attgcagaat aattatagcc aaaaaggaag
    16501 ccctttatga attgtaggac ttccttttct tatccagaaa ttgatctagc tctctctgat
    16561 ttcgaagaat agtgacttta tgtgaatatt cttggcaaag tttttggtaa ttttcttttt
    16621 gagttttgct acgcccatcc caaagaatcc atctgataaa ctcccagtca aagcgttcag
    16681 ggcaatctgc cgccatactt tctctgactt ttccacggta tttaagataa cgcttaaagg
    16741 ctctaaagag acaggtcaat ggcaaaaaat tgagaaagat gatttggtca gcttcttgca
    16801 ttcgttcttg gtagtagcac caagaataat taccatcgat gacccaagct ttatgcttgg
    16861 tgagaaagtt ttttatctcg gttaacatcc attcgcagtc actgtcttgc caaccaggtt
    16921 gaaattggag tgtgtccatg tgcagttttg gaatggagta gtagttagat aacttttctg
    16981 ctagagttga cttaccagaa ccagaatatc cgataattgt gattttcatt ttctaccttt
    17041 tcctatttgg agacaaaaaa acagcctcta tggactgttt cttatttagc aagtttagtt
    17101 gaaagacgag ctttatcgcg gcttgctttg tttttgtgaa tcaaaccttt agtttctgct
    17161 ttatcgatag ctgagctagc agcacggaaa agttcttcag atgggtttgc ttcgaaagct
    17221 tttatagcag tacgcatagc tgatttttga gctgagttct tttcgttttg tttaacgttc
    17281 aattcagcgc gtttgatagc tgatttaatg tttgccaatg ttcttacctc catatttact
    17341 aactatacca ttatatatga aaacttacgt tttgacaagg gaaaattact tttttaagta
    17401 aatttcatcg atttcatggt tcttgctttt atgaagaatc acttctgcac gatttctggt
    17461 tggttcaata taattttgca gatttgtgag attgatactg atccagacct gatgggcaaa
    17521 ggactccact tccccaatcg gcatctgagt aaaacgataa tagtagctat cagggtcgtt
    17581 ttgggctagg ctcagcattt tcaagaaacg gtccagatac caactttcaa tatcatccac
    17641 tccagcatct acatagatgg aaaagtcaaa gaagtcagtg atatagagac gatcgttttg
    17701 tggattttga aagacattaa ttccctcaac aattacaaaa tcagcagctt tgacactttg
    17761 tttcttttcg ggtacgatgt cgtaaacttc atgagaatag acaggaatat ctacatcttg
    17821 tccatttttg atgcggtcca agaagttgag aagagcttcc atatcatagc tttcaggaaa
    17881 tcctttacga tttaaaatcc cctgctcaat caaggtttga ttgggatata gaaaaccatc
    17941 agttgtaacc aactcaaccg tagcatctgt aaacgtacgg gacagtagga tttgaagtag
    18001 gcgactggtt gtggattttc caacggcaac actcccagaa accccaataa taaaaggttg
    18061 agatttactt tcacgttgga ggaaaattcc ttttgaaaag gctaaatctt ccttagttcg
    18121 cttgtaaatc tgaatcagat gagccaaggg gagatagata tctgtaacgt cttggagact
    18181 gatttggtca ttaaaactct tgatagattc caattcttct tctgtcaaag gaggtgttgt
    18241 ctttcgatgt aaagattgcc aagtctggcg gctgattttt tcaaaatgta aaaattcgtt
    18301 ggtcatttgt tttcccctag atattttgtc tatcatacca taaaaagcta aaaaaataaa
    18361 gcggtttctt gaatgtggta agtcaatggt atatagtata agtgatcaat ttattgatga
    18421 aataggagat agattctact gatttataag cttataaagg gggcttttta gttcacaact
    18481 tataggaggt gtactatgaa aatcttaaaa cgttacatat tggaactctg ttttatttta
    18541 agttttgctt taccttttat aaaaggaacc aatgcagata atggtagatg ctttgtggaa
    18601 acctattacg gttttacttt tttgatggaa catgctattg taacagctgt ctttatctgt
    18661 tcgttcttaa ttgctttctt actaaaaaac gatggacgaa atggattgct gcgggtagtt
    18721 attgcttttt agtcctacgg attgcgacag agggttattt cttccacatg tcactagaag
    18781 atttgatacg actttggaca agtttggaaa tcctgacaca aacgtatcag ttgggctttt
    18841 atctaaacat tttgttagga attttgttga taataaagta ttttaaggtt aagcaataga
    18901 aataataatc tgcctgatta tagatgataa actttttgtt tttatctgga ctgtgatatt
    18961 tatagttcta aatggtttat tatttataag tgttgaaaga gattgaagaa aatggcttcg
    19021 tgacttgctt tcttcggtct ttttcgtttt attatcaatt tgtaaacgat ttacaatttg
    19081 agtcaaatta tggtaaaata gtgtcatgag taaaatgtac tatgcagaaa atcctgacgc
    19141 tgctcacgac attcatgagt tgagagtgga cttgttggga gaaaaaatga cttttttgac
    19201 agatgcgggt gtttttagca agaaaatggt tgactttgga agtcaactct tgctcaagtg
    19261 tctggatgtc aaccaaggag agacagtcct agatgtaggc tgtggctatg gtccattagg
    19321 tttgtccttg gtcaaggttt acggagttca ggcgaccatg gttgatatta acactcgtgc
    19381 cctggattta gctcagagaa atgctgaaaa aaataatgca aaagcgacga tatttcaatc
    19441 taatatttat gcaagagttc aagggcgatt tgaccatgtc atttccaatc ctcctatccg
    19501 tgcgggcaag caagtcgttc atgaaatcat cgagaaaagt aaagatttct tggaaattgg
    19561 tggagatttg accatcgtca tccagaaaaa acaaggagct ccaagtgcca agtctaagat
    19621 ggaagatgtg tttggcaatt gtgaaatcct taaaaaagac aagggatact atatccttag
    19681 aagtgtgaaa gaatgagagc agttgattta atccaaaaaa aacgagacgg tcaagaactg
    19741 acttcaagtg aaattgaatg gctgatagaa ggctatgtat caggaactgt tcctgattat
    19801 cagatgtctg cctttgctat ggctgtttat tttaaaggaa tgacgactcg agaaatctct
    19861 gatttaacga tgaatatggt taagactggg caagagtttg acctgtcagc cattgatggt
    19921 gtgaaagttg acaagcattc tactggtggt gtcggcgata aggtaacctt gattttagct
    19981 cctcttgttg ctagcttcgg tgtgcctgta gcaaaaatga gtggtcgtgg tcttggccat
    20041 acaggcggaa caattgataa attggagtcc attaagggct atcaagtaga acgtagtcaa
    20101 gaggatttta ttcgtcaggt tcaggatatt ggagtatctg tcattgggca atcagaccag
    20161 ctggtcaaag cagataagct tctctatgcc cttcgtgatg tgaccgcaac tgtcgacaca
    20221 attcctttga ttgcgagttc ggtgatgagc aagaaaattg cggcaggggc ggatgctatt
    20281 ttgctagacg tgactgtcgg tgagggtgcc ttcatgaaga cggttgatga ggcgcgtgag
    20341 ttggctcaaa ctatggtaga tcttggtaag gttgttggac ggaagacagt agcagtgatt
    20401 acggatatga gccagccttt gggacgagcg attggaaatc gtctggaaat ccttgaagca
    20461 ttggagattt tgcaaggtca aggacgtcag gatattaccc actttatttg tgaattggct
    20521 caaattatgc ttggtttggc aaatgttaac aaaactgttg aagaagttcg ccaacatctt
    20581 gaaaatggtc aagcactggc taagtttgag gaaatggtgc aagcccaagg tggagacttg
    20641 gaagacctct atcgtcctgt aaatgtagct catgtggtgg aaatccctgc tcaggaaacg
    20701 ggtgtcattt cagctcttcc agctatggac tttggtcttt atgccatgag gctgggtgct
    20761 ggtcgtgcag ttaagtctga tgtcttggac tatgaaacag gaattgtttt tgaaaagaag
    20821 attggagact ccgttcaaaa gggtgaaatt gttgcaaaag tatacacaaa tgaaaaaatt
    20881 ccacctcaac tagttacaga tttccaaaaa tgtgttaaaa taagtgatga agtgaaaaaa
    20941 atccgtgaaa ttgtagaaat catctcctaa atggagggaa aaccgaaatg aaattaaata
    21001 aatatataga tcatacgctt ttaaaacaag atgcaaagaa aaaacaaatt gatagtttgt
    21061 tgtctgaggc tagagagtat gactttgcca gtgtttgcgt taatccgacc tgggttgaac
    21121 atgctaaaaa aggacttgaa ggcacagatg ttaaggtttg cacagtagta ggtttccctt
    21181 tgggagcaac aacttcagcc gtgaaagcat ttgagacaaa agaagctatc caaaatggtg
    21241 cagatgagat tgatatggtg atcaatgttg gagctctcaa atcaggtaat ttagccttgg
    21301 ttgagtcaga tattcgcgca gtagtggaag caagtggtga taagttagtg aaagtcatta
    21361 ttgaagcttg ccttctgaca gaccaagaaa aaattgttgt ttgccaattg gcccaaaaag
    21421 ctggggctga ctttgttaaa acatctactg gcttttcaac tggtggtgct acgatagcag
    21481 atgttagatt aatgcgtgaa acagttggat ctgatatggg agtcaaggct gctggtggag
    21541 ctcgttctta tgcagatgct cttgcctttg tcgaagcagg tgcgacccgt atcggaacgt
    21601 cagctggggt agctatttta aaaggagaat tggcagatgg cgactactga gttgattgaa
    21661 ctggcaattg aaaccagcaa acatgcctat gtcccctatt ctcactttcc tatcggagca
    21721 gttttagtag ccaaagacgg aagtgtttac acgggagtga atatcgaaaa tgctagctat
    21781 cctttgacca attgcggtga gagaacagct gtttttaagg ctatatctga aggccaaaga
    21841 gaattttcag aattgattgt ctatggtcaa actgaaaaac cgattttacc atgtggtgct
    21901 tgtcgccaag taatggtcga attttttgaa caagatttaa aagtgacctt agtcgcaaaa
    21961 gataaatcga cggtcgagat gacggtcggg gagttacttc catactcttt tacagactta
    22021 aattagtctg agtcgctctt tgagtggcaa gggtctttgt gaccaatcaa tccatacttg
    22081 caacatcgtt gcacatctta tttaggaggt tcagtaatga acaagaaaca atggctaggt
    22141 cttggcctag ttgcagtggc agcagttgga cttgctgcat gtggtaaccg ctcttctcgt
    22201 aacgcagctt catcttctga tgtgaagaca aaagcagcaa tcgtcactga tactggtggt
    22261 gttgatgaca aatcattcaa ccaatcagct tgggaaggtt tgcaagactg gggtaaagaa
    22321 cacaatcttt caaaagataa cggtttcact tacttccaat caacaagtga agctgactac
    22381 gctaacaact tgcaacaagc ggctggaagt tacaacctaa tctttggtgt tggttttgcc
    22441 cttcacaatg cagttgaaga agcagctaaa gaacacactg acttgaacta tgtcttgatt
    22501 gatgatgtga ttaaagacca aaaaaatgtt gctagcgtaa ctttcgctga taatgagtca
    22561 ggttaccttg caggtgtggc tgcagcaaaa acaactaaga caaaacaagt tggttttgta
    22621 ggtggtatcg aatctgaagt tatctctcgt tttgaagcag gattcaaggc tggtgttgcg
    22681 tcagtagacc catctatcaa agtccaagtt gactacgctg gttcatttgg tgatgcggct
    22741 aaaggtaaaa caattgcagc cgcacaatac gcagccggtg cagatattgt ttaccaagta
    22801 gctggtggta caggtgcagg tgtctttgca gaggcaaaat ctctcaacga aagccgtcct
    22861 gaaaatgaaa aagtttgggt tatcggtgtt gatcgtgacc aagaagcaga aggtaaatac
    22921 acttctaaag atggcaaaga atcaaacttt gttcttgtat ctactttgaa acaagttggt
    22981 acaactgtaa aagatatttc taacaaggca gaaaaaggag aattccctgg cggtcaagtg
    23041 atcgtttact cattgaagga taaaggggtt gacttggcag taacaaacct ttcagaagaa
    23101 ggtaaaaaag ctgtcgaaga tgcaaaagct aaaatccttg atggaagcgt aaaagttcct
    23161 gaaaaataat ggatggaagt catttcttag gaagcggcca agggccgctt ttttaagagt
    23221 tgagacaaag tcattttgtc tcagtaaagc ttgctactag acaaactagc aagttttatt
    23281 gaaataaaat aagactctga aaggaagagc acatggcaca cgaaaatgcc attgagatgc
    23341 gtgatattac caaggtgttt ggtggatttg ttgccaacga caaaatcaac ttgcacctac
    23401 gaaaaggtga aattcatgca cttttaggag aaaatggggc tggtaagtcc acgctaatga
    23461 acatgttagc aggccttctt gaaccaacta gtggtgaaat cgcggtcaac ggtcaagttg
    23521 tcaatctcga ctccccatct aaagcagcta gcttgggaat cgggatggtt caccagcact
    23581 ttatgttggt tgaagccttc acagtggctg aaaacatcat tttaggtagt gaattgacta
    23641 aaaatggtgt gctagatatc gctggagcta gcaaagaaat caaggctctt tctgaacgtt
    23701 atggcttagc tgttgaccct tctgccaagg tagcagatat ctcagttgga gcccaacaac
    23761 gtgtagaaat tttaaaaaca ctttatcggg gggctgatat ccttatcttt gacgaaccaa
    23821 cggctgtttt gactccatca gaaattgatg agttgatggc tattatgaaa aatcttgtca
    23881 aagaaggaaa atcaattatc ttgattaccc acaaattgga tgaaattcga gcagtttctg
    23941 accgtgttac agttatccgt cgtgggaaat caattgaaac cgttgaaatt gcaggggcta
    24001 ccaatgctga tttggcggaa atgatggtag gacgttctgt ttcctttaaa acagagaagc
    24061 aagcctctaa accaaaagaa gtggttttgt ctatcaaaga tttggtggtc aatgaaaacc
    24121 gtggtgttcc agctgttaaa aatctgtcct tggatgttcg tgctggagag attgttggta
    24181 ttgcggggat tgatggaaat ggtcagtctg aactgattca agccattaca ggtcttcgca
    24241 aggttgaatc tggtagcatt gagctaaaag gagattcaat tgtaggcttg cacccacgtc
    24301 agattacaga actaagtgtt gggcacgttc cagaagaccg tcaccgtgat ggcttgattt
    24361 tggaaatgat gatatctgaa aatattgccc ttcaaaccta ctataaagaa ccacatagta
    24421 aaaatggaat tttgaattat tcaaatatta cttcttatgc taaaaagctg atggaagagt
    24481 ttgatgttcg cgctgccagt gaattagttc ctgcagctgc actctcagga ggaaatcaac
    24541 aaaaagcaat tattgctcgt gaaattgatc gagatcctga tctccttatc gttagccagc
    24601 caactcgtgg gttggatgtc ggtgccattg agtatatcca caaacgcttg attgaagagc
    24661 gtgataatgg caaggctgtc cttgttgtca gctttgaatt ggatgagatt ttaaacgtct
    24721 cagaccgtat tgccgttatc cacgatggta agattcaagg tattgtatca ccagaaacaa
    24781 ccaataaaca agaacttggt gtcttgatgg ctggtggaaa cttgggaaag gagaagagtg
    24841 atgtctaaaa aattacaaca aatttcggtt cccttgattt ctgtattcct aggaatttta
    24901 ctcggagcca ttgtcatgtg gatcttcggt tatgatgcta tttggggcta cgaagaattg
    24961 ttctatacag cctttggcag tctgcgtggg attggagaaa tcttccgtgc tatgggtcct
    25021 ctggtcttga ttggtcttgg ttttgccgtt gccagtcgag ctggtttctt taacgtcgga
    25081 cttcctggtc aggctttggc aggttggatt ctcagtggtt ggtttgccct gtcgcatcca
    25141 gatatgcccc gtcccttgat gattctagca accatcgtga ttgccttgat tgctggtggg
    25201 attgtcggag cgattccagg tattcttagg gcctatctag ggacgtcaga ggttattgta
    25261 accatcatga tgaactacat tgtcttgtat gtagggaatg cctttatcca tgctttccct
    25321 aaagacttca tgcaaagtac agattcgacc attcgtgttg gggctaatgc aacctatcag
    25381 acaccttggt tggctgagtt gactggtaac tcacggatga atattggtat tttctttgcc
    25441 atcattgccg ttgcagttat ttggttcatg ctcaagaaaa caactcttgg ttttgaaatc
    25501 cgtgcagttg gtcttaatcc acatgcttca gaatatgctg gtatttctgc caagcggact
    25561 attatcctat ctatgattat ttcaggtgcc ttggcaggtc ttggtggagc tgttgaaggt
    25621 ttgggaacct tccagaacgt ctatgttcaa ggttcgtcat tagctatcgg atttaacgga
    25681 atggcggtta gtttgcttgc ggccaactca ccaattggta tactttttgc agccttccta
    25741 tttggcgttc tccaagttgg ggctcctggt atgaatgcgg cgcaggtacc atctgagctt
    25801 gtcagcattg taacagcgtc tattatcttc tttgtcagtg ttcattacct tatcgaacgc
    25861 tttgtcaaac cgaaaaaaca agttaaagga ggtaagtaaa gatgtctatt ataaccttgc
    25921 tccccctctt ggtgtcttct atgctgattt actcagcacc tctcatcttt acaagtatcg
    25981 gtggtgtttt ctctgaacgt ggtggtgtgg taaacgttgg ccttgaagga attatggtta
    26041 tgggtgcctt ttctggagtt gtctttaacc ttgaatttgc agaacaattt ggagcagcaa
    26101 ctccatggct atccttgctt gtagcaggat tggttggtag tgttttctct atcatccacg
    26161 cagcagcgac ggttcatttc cgtgcagacc atgttgtcag cggtacggta ttgaacttga
    26221 tggcgcctgc cttggctgtt ttcttagtta aagttcttta taacaaagga caaaccgaca
    26281 acctaagtca aacttttgga cgctttgatt tcccagtctt ggcaaatatc ccagtgattg
    26341 gtgatatctt cttcaagtca actagtctac ttggttatct ggcgattgcc ttctcattcc
    26401 ttgcttggtt tattctcttt aagactcaat ttggtcttcg tctccgctct gtcggtgaac
    26461 atcctcaagc agcggatacc ttgggaatca acgtctacaa gatgagatat ttagggatta
    26521 ttatttcagg ttttctaggt ggaattggcg gagcgattta tgcgcaatca atctcagtta
    26581 acttctcagt gacaactatt gttggacctg gatttatcgc ccttgctgcg atgatctttg
    26641 ggaaatggaa tccaatcggt gctatgcttt ctagtctctt ctttggactt tcacaaagtt
    26701 tggctgttat cggttctcaa ttgccgttcc tacaaggagt gccagcggtt tatcttcaaa
    26761 ttgcacctta tgttttgaca attcttgtct tagcagcctt ctttggaaaa gcagtcgcac
    26821 caaaagcaga tggtatcaac tacatcaaat caaaataagc atacaaaaaa acgtcagtcc
    26881 aatgactgaa ctgcccccca aaagttagac agaaaaaatc taacttttgg ggtgttttta
    26941 ttatgaaatt aa
//
LOCUS       DAVHIZ010000027        26557 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.027, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000027 DAVHIZ010000000
VERSION     DAVHIZ010000027.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26557)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26557)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26557
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.027"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..269)
                     /locus_tag="VVO18_001186"
     CDS             complement(<1..269)
                     /locus_tag="VVO18_001186"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818355.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU5586353.1"
                     /translation="MSEYWFSTNVDQIDEVDGKQCLIYSYYNVKASRNVEVLKGRSGT
                     KKGLDYWEPYAPQKQYEMERLPKNKYIGSSSTDRWDGIEKNVVFC"
     gene            complement(320..484)
                     /locus_tag="VVO18_001187"
     CDS             complement(320..484)
                     /locus_tag="VVO18_001187"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516551.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA cytosine methyltransferase"
                     /protein_id="HEU5586354.1"
                     /translation="MGKIVAIDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLN
                     NPEVSVIDME"
     gene            complement(565..3216)
                     /locus_tag="VVO18_001188"
     CDS             complement(565..3216)
                     /locus_tag="VVO18_001188"
                     /EC_number="6.1.1.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009732359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="valine--tRNA ligase"
                     /protein_id="HEU5586355.1"
                     /translation="MSKELSPKYNPAEVEAGRYQKWLDADVFKPSGDQKAKPYSIVIP
                     PPNVTGKLHLGHAWDTTLQDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEERLRGEG
                     ISRYDLGRESFLTKVWEWKDEYATTIKEQWGKMGLSVDYSRERFTLDEGLSKAVRKVF
                     VDLYKKGWIYRGEFIINWDPAARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVAT
                     TRPETMFGDVAVAVNPEDPRYKDLIGKNVILPIANKLIPIVGDEHADPEFGTGVVKIT
                     PAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAFEFSGMDRFEARKAVVAKLEEIGALV
                     KIEKRVHSVGHSERTGVVVEPRLSTQWFVKMDQLAKNAIANQDTEDKVEFYPPRFNDT
                     FLQWMENVHDWVISRQLWWGHQIPAWYNADGEMYVGEEAPEGDGWTQDEDVLDTWFSS
                     ALWPFSTMGWPEVDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGRQPFQNVL
                     IHGLIRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLSNGSAPGQDVRFSYEKMDA
                     SWNFINKIWNISRYILMNNEGLTLDVVHDNVTKVATGEAGNVTDRWILHNLNETIGKA
                     TANFDKFEFGVAGHILYNFIWEEFANWYVELTKEVLYSDNEDDKVITRSVLLYTLDKI
                     LRLLHPIMPFVTEEIFGQYAEGSIVTAAYPTVNPAFEDLAAHTGVESLKDLIRAVRNA
                     RAEVNVAPSKPITILVKTSDSDLEAFFNSNVNYIKRFTNPEHLEIASTIPAPELAMSS
                     VITGAEIYLPLADLLNVEEELARLDKELAKWQKELDMVGKKLSNERFVANAKPEVVQK
                     ERDKQADYQAKYDATVARIDEMKKLVK"
     gene            complement(3209..3787)
                     /locus_tag="VVO18_001189"
     CDS             complement(3209..3787)
                     /locus_tag="VVO18_001189"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000550018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEU5586356.1"
                     /translation="MHLFIIGAPASGKMTIGQELSRLTDATLFYNHQAIDFALEIYQD
                     YTEEMWEFVRGITFSFLGASARNQRSVILTDVIDFSNQYHLIYLKQIQSLLDDYHQEI
                     LFVELETSLEECIRRNRTENRLKYKPLKRHIEVSEREIIETAETLQLNSQHQPNELNH
                     YFKINNTNLSAEEAAKQIQNKINKIEKGHTHV"
     gene            complement(3787..4347)
                     /locus_tag="VVO18_001190"
     CDS             complement(3787..4347)
                     /locus_tag="VVO18_001190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000124561.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586357.1"
                     /translation="MARTELPDKIETECLVLRVRTVADAEDIFDYASLPEVAYPAGFP
                     PVKTLEDEIYYLEHILPERNQKENLPAGYGIVVKGTDKIVGSVDFNHRHEDDVLEIGY
                     TLHPDYWGRGYVPEAARALIDLAFKDLGLHKIELTCFGYNLQSQRVAEKLGFTLEARI
                     RDRKDAQGNCCDDLRYAFLKSEWEVI"
     gene            complement(4334..4783)
                     /locus_tag="VVO18_001191"
     CDS             complement(4334..4783)
                     /locus_tag="VVO18_001191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavin reductase"
                     /protein_id="HEU5586358.1"
                     /translation="MIGVVARENAAEQIKQYQKFTVNISDETSMLAMEQAGFISHQEK
                     LERLGVHYEISERTQTPILDACPLVLDCRVDRIVEEDGICHIFAKILERLVVPELLDE
                     KGHFKNQLFAPTYFMGDGYQRVYRYLDKRVDMKGSFIKKARKKDGKN"
     gene            complement(5196..5591)
                     /locus_tag="VVO18_001192"
     CDS             complement(5196..5591)
                     /locus_tag="VVO18_001192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000038635.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase"
                     /protein_id="HEU5586359.1"
                     /translation="MSKKLNRKKQLRNGLRRAGAFSSTVTKVVDETKKVVKRAEQSAS
                     AAGKAVSKKVEQAVEATKEQAQKVANSVEDFAANLGGLPLDRAKTFYDEGIKSASDFK
                     NWTEKELLALKGIGPATIKKLKENGIKFK"
     gene            complement(5687..5941)
                     /locus_tag="VVO18_001193"
     CDS             complement(5687..5941)
                     /locus_tag="VVO18_001193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000119704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1912 family protein"
                     /protein_id="HEU5586360.1"
                     /translation="MSYEQEFMKEFEAWVNTQIMINDMAHKESQKVYEEDQDERAKDA
                     MIRYESRLDAYQFLLGKFENFKAGKGFHDLPEGLFGERNY"
     gene            complement(5951..7285)
                     /locus_tag="VVO18_001194"
     CDS             complement(5951..7285)
                     /locus_tag="VVO18_001194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000752887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF438 domain-containing protein"
                     /protein_id="HEU5586361.1"
                     /translation="MADERIHVLRDILLELHNGASPESVQDRFDATFTGVSAIEISLM
                     EHELMNSDSGVTFEDVMELCDVHANLFKNAIKGVEVSDTEHPGHPVRVFKEENLALRA
                     ALIRIRRLLDTYELMEDEEMLAEMRKGLVRQMGLVGQFDIHYQRKEELFFPIMERYGH
                     DSPPKVMWGVDDQIRELFQTALTTAKSLPEVSISSVKEAFEAFATEFESMIFKEESIL
                     LMILLESFTQDDWLQIAEESDAYGYAIIRPSEKWVPERQSFIEEKIAEEPVQLDTAEG
                     QVQQVIDTPEGHFTITFTPKEKEAVLDRHSQQAFGNGYLSVEQANLILNHLPMEITFV
                     NKEDIFQYYNDNTPADEMIFKRTPSQVGRNVELCHPPKYLDKVKTIMKGLREGSKDKY
                     EMWFKSESRGKFVHITYAAVHDEDGEFQGVLEYVQDIQPYREIDTDYFRGLE"
     gene            complement(7285..7518)
                     /locus_tag="VVO18_001195"
     CDS             complement(7285..7518)
                     /locus_tag="VVO18_001195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1858 domain-containing protein"
                     /protein_id="HEU5586362.1"
                     /translation="MDNIIDVSIPVAEVVDKHPEVLEILVELGFKPLANPLMRNTVGR
                     KVSLKQGSKLAGTPMDKIVRTLEANGYEVIGLD"
     gene            7549..7623
                     /locus_tag="VVO18_001196"
                     /pseudo
     CDS             7549..7623
                     /locus_tag="VVO18_001196"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829418.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            complement(7831..7983)
                     /locus_tag="VVO18_001197"
     CDS             complement(7831..7983)
                     /locus_tag="VVO18_001197"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000668195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586363.1"
                     /translation="MKFFWGLLAIIFIKPIIGIVKFFWMIISFAVQLLFYKIVFKILD
                     WLFKLI"
     gene            complement(7980..8162)
                     /locus_tag="VVO18_001198"
     CDS             complement(7980..8162)
                     /locus_tag="VVO18_001198"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000522940.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586364.1"
                     /translation="MGLIKTLAKIYGNYFLTVQGVKVMKTIKKDDHVVVGLGKLFIAD
                     KLMDTARWLIKPEDKK"
     gene            complement(8164..8943)
                     /locus_tag="VVO18_001199"
     CDS             complement(8164..8943)
                     /locus_tag="VVO18_001199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000840413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586365.1"
                     /translation="MAEQDLAMQVLQQVVKLPVVKVDRSKFLVDKFSKELDPKDIPTL
                     LEQGPTTLLSQEILDRVANACIRDNVLLASGTSVLAGLPGGLAMAITIPADVAQFYAF
                     SLKLAQELGYIYGYEALWTSREELSEDAQNTLLLYLGVMLGVNGTAALLRAGGITIAK
                     QVMKTVPNKALTKTLWYPILKKVLRIFGVNLTKGGLAKGMGKFIPILGGIISGGLTFA
                     TMKPMGESLQKELSKLVNYSEVQYQEDVETIRKEAEIIEGE"
     gene            complement(9222..9572)
                     /gene="rbfA"
                     /locus_tag="VVO18_001200"
     CDS             complement(9222..9572)
                     /gene="rbfA"
                     /locus_tag="VVO18_001200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001273594.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosome-binding factor RbfA"
                     /protein_id="HEU5586366.1"
                     /translation="MANHFRTDRVGMEIKREVNEILQKKVRDPRVQGVTITDVQMLGD
                     LSVAKVYYTILSNLASDNQKAQIGLEKATGTIKRELGRNLKLYKIPDLTFVKDESIEY
                     GNKIDEMLRNLDKN"
     gene            complement(9823..12615)
                     /gene="infB"
                     /locus_tag="VVO18_001201"
     CDS             complement(9823..12615)
                     /gene="infB"
                     /locus_tag="VVO18_001201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="translation initiation factor IF-2"
                     /protein_id="HEU5586367.1"
                     /translation="MSKKRLYEIAKELGKESKEVVARAKELGLDVKSHSSSVEEAVAA
                     KIAASFKPAAAPKVEAKPAAPKVSAEKKAEKSEPAKPAVAKEEAKPAEPVAPKTEKVA
                     AKPQSRNFKAEREARAKEQAERRKQNKGNNRDQQQNGNRQKNDGRNGGKQGQSNRDNR
                     RFNDQAKKQQGQQKRRNERRQQEDKRSNQAAPRIDFKARAAALKAEQNAEYARSSEER
                     FKQYQAAKEALAQANKRKEPEEIFEEAAKLAEQAQQVQAVVEVVPEKKEPAVDTRRKK
                     QARPDKNRDDYDHEEDGPRKQQKNRSSQNQVRNQKNSNWNNNKKNKKGNNKNNRNQTP
                     KPVTERKFHELPTEFEYTDGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGET
                     IELLMVDYGIEAKQKVEVDNADIERFFVEDGYLNEDELVERPPVVTIMGHVDHGKTTL
                     LDTLRNSRVATGEAGGITQHIGAYQIVENGKKITFLDTPGHAAFTSMRARGASVTDIT
                     ILVVAADDGVMPQTIEAINHSKAANVPIIVAINKIDKPGANPERVIGELAEHGVMSTA
                     WGGDSEFVEISAKFNQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAV
                     ATLLVQQGTLNVQDPIVVGNTFGRVRAMTNDLGRRVKVAGPSTPVSITGLNEAPMAGD
                     HFAVYEDEKSARAAGEERAKRALMKQRQATQRVSLENLFDTLKAGELKSVNVIIKADV
                     QGSVEALSASLQKIDVEGVKVTIVHSAVGAINESDVTLAEASNAFIVGFNVRPTPQAR
                     QQAEADDVEIRLHSIIYKVIEEMEEAMKGMLDPEFEEKVIGEAVIRETFKVSKVGTIG
                     GFMVINGKVARDSKVRVIRDGVVIYDGELASLKHYKDDVKEVTNGREGGLMIDGYNDI
                     KMDDVIEAYVMEEIKR"
     gene            complement(12632..12931)
                     /locus_tag="VVO18_001202"
     CDS             complement(12632..12931)
                     /locus_tag="VVO18_001202"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399195.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxQ-related RNA-binding protein"
                     /protein_id="HEU5586368.1"
                     /translation="MNKQKISNLLGLAQRAGRIISGEELVVKAIQDGKAKLVFLAHDA
                     GPNLTKKIQDKSHYYQVEIVTVFSTLELSIAVGKSRKVLAVTDAGFTKKMRSLME"
     gene            complement(12924..13217)
                     /locus_tag="VVO18_001203"
     CDS             complement(12924..13217)
                     /locus_tag="VVO18_001203"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000857559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YlxR family protein"
                     /protein_id="HEU5586369.1"
                     /translation="MKTRKIPLRKSVVSNEVIDKRDLLRIVKNKEGQVFIDPTGKANG
                     RGAYIKLDNAEALEAKKKKVFNRSFSMEVEESFYDELIAYVDHKVKRRELGLE"
     gene            complement(13239..14375)
                     /gene="nusA"
                     /locus_tag="VVO18_001204"
     CDS             complement(13239..14375)
                     /gene="nusA"
                     /locus_tag="VVO18_001204"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000032293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusA"
                     /protein_id="HEU5586370.1"
                     /translation="MSKEMLEAFRILEEDKGIKKEDIIDAVVESLRSAYRRRYGQSDS
                     VAIDFNEKTGDFTVYTVREVVDEVFDSRLEISLKDALAINSAYELGDKIKFEEAPAEF
                     GRVAAQSAKQTIMEKMRKQTRAITYNTYKEHEQEIMSGTVERFDNRFIYVNLGSIEAQ
                     LSKQDQIPGEVFASHDRIEVYVYKVEDNPRGVNVFVSRSHPEMIKRLMEQEIPEVYDG
                     TVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRGGANIKKITSKFHPARYDAKNDR
                     MVPIEENIDVIEWVADPAEFIYNAIAPAEVDQVIFDENDSKRALVVVPDNKLSLAIGR
                     RGQNVRLAAHLTGYRIDIKSASEFEAMEDAASVELEVENDTVEE"
     gene            complement(14419..14898)
                     /gene="rimP"
                     /locus_tag="VVO18_001205"
     CDS             complement(14419..14898)
                     /gene="rimP"
                     /locus_tag="VVO18_001205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000338698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimP"
                     /protein_id="HEU5586371.1"
                     /translation="MDAIATIVELVREVVEPVIEAPFELVDIEYGKIGSDMILSIFVD
                     KPEGITLNDTADLTEMISPVLDTIKPDPFPEQYFLEITSPGLERPLKTKDAVAGAVGK
                     YIHVGLYQAIDKQKVFEGTLLAFEEDELTMEYMDKTRKKTVQIPYSLVSKARLAVKL"
     gene            complement(15024..15659)
                     /gene="trmB"
                     /locus_tag="VVO18_001206"
     CDS             complement(15024..15659)
                     /gene="trmB"
                     /locus_tag="VVO18_001206"
                     /EC_number="2.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001266107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(46)-N7)-methyltransferase TrmB"
                     /protein_id="HEU5586372.1"
                     /translation="MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVE
                     VGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEAGVSNIKLLWVDGSDLTD
                     YFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFE
                     YSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF"
     gene            complement(15656..16450)
                     /locus_tag="VVO18_001207"
     CDS             complement(15656..16450)
                     /locus_tag="VVO18_001207"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000363010.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphotransferase family protein"
                     /protein_id="HEU5586373.1"
                     /translation="MDLGDNELTLTPIPGKSGKAYMGSYPDGKRIFVKMNTSPILPGL
                     AREQIAPQLLWSRRLADGRDMCAQEWLTGKILTPYDMNRKQIVNILTRLHRSRPLMTQ
                     LSRLGYAMETPVDLLQSWQETAPDALRKNHFISEVMADLRQTIPGFREDHATIVHGDV
                     RHSNWIETDSGLIYLVDWDSVRLTDRMFDVAHMLCHYISEHQWKEWLTYYGYKYNQTV
                     LSKLYWYGQLSYLSQISKYYMNQDLENVNREIHGLRHFRDKYGKRR"
     gene            complement(16611..17222)
                     /locus_tag="VVO18_001208"
     CDS             complement(16611..17222)
                     /locus_tag="VVO18_001208"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5586374.1"
                     /translation="MEFFDKFHALCFGFLVLIIVITVPYTINHGDFFQNESALIIVSL
                     LVTSLSVAYARKFEMISFGMLSKKQLLLFIAIFLLSVLETLVYIHFFAVSSGSGVQHL
                     AEVSRGISLSLILTTSVFGPIQEELIFRGLLQGAVFDNSWLGLVLTSSLFSFMHGPSN
                     VPSFIFYLLGGLLLGLAYKKSQNLWVSTLVHMFYNSWPLLYYL"
     gene            complement(17373..17606)
                     /locus_tag="VVO18_001209"
     CDS             complement(17373..17606)
                     /locus_tag="VVO18_001209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809974.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586375.1"
                     /translation="MYKHLFFLDSKTLDRLTPYILVLASDTIAFNVFVLTFVSAVVFN
                     FLNSMLALMAIFIGAGYVVGFWLLILNENQRAN"
     gene            complement(17648..18337)
                     /locus_tag="VVO18_001210"
     CDS             complement(17648..18337)
                     /locus_tag="VVO18_001210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760553.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5586376.1"
                     /translation="MKKYQLLFKISAVFSYLFFVFGLSQMTLIIQNYWQFSSQIGNFV
                     WIQNFLSLLFSGVMIWILVKTGHGYLFHIPRKKWLWYSILTVLVVVLQISFNVQTAKH
                     VQSTAEGWAVLIGYSGTNFAELGIYVTLFFLTPLMEELIYRGLLQHAFFKHSRFGLDL
                     LLPSILFALPHFLSLPSLLDIFVFATFGIIFAGLTRYTKSIYPSYAVHVINNIVATFP
                     FLLTFLHRVLG"
     gene            complement(18369..18602)
                     /locus_tag="VVO18_001211"
     CDS             complement(18369..18602)
                     /locus_tag="VVO18_001211"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ComC/BlpC family leader-containing
                     pheromone/bacteriocin"
                     /protein_id="HEU5586377.1"
                     /translation="MDTKMMSQFAVMDNEMLARIEGGDVSDIYRGYANQVSPFGSYPP
                     ILKNSGPFPVSGYCPRGYHDRGYIGAGFHLCGI"
     gene            complement(18846..19079)
                     /locus_tag="VVO18_001212"
     CDS             complement(18846..19079)
                     /locus_tag="VVO18_001212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000379965.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEU5586378.1"
                     /translation="MDTKIMEQFHEMDITMLSSIEGGKNNWQTNVLEGGGAAFGCAAG
                     GVKYGRLLGPWGAAIGGIGGAVVCGYLAYTATS"
     gene            complement(19229..20032)
                     /locus_tag="VVO18_001213"
                     /pseudo
     CDS             complement(19229..20032)
                     /locus_tag="VVO18_001213"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(20235..20639)
                     /locus_tag="VVO18_001214"
     CDS             complement(20235..20639)
                     /locus_tag="VVO18_001214"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="immunity protein"
                     /protein_id="HEU5586379.1"
                     /translation="MKKIFATKRNVFLVRLLLGQIPLVVSTYLFLSRQFLNFSLVFQF
                     LLVIINLASILATVYLTREMRIRKFEDDDLVSPRTNQLMFIGLTGFMSIICLYRGITA
                     AESYQQIIAYIGAVLCLLIMLLLIWGLKYYKK"
     gene            complement(20669..20857)
                     /locus_tag="VVO18_001215"
     CDS             complement(20669..20857)
                     /locus_tag="VVO18_001215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586380.1"
                     /translation="MAALNTSLTTNIKFGLVGTVGGRFAGYGMYVLGYPGDYLDITNH
                     RVVSAKTSHKSYQILEND"
     gene            complement(21084..21659)
                     /locus_tag="VVO18_001216"
     CDS             complement(21084..21659)
                     /locus_tag="VVO18_001216"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000497530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5586381.1"
                     /translation="MFVGFLVYVIVATVGYTINQGDYFQNEHLFIIAKTFLISLSVAY
                     AKWFDMISLRRLTKKEVLLFIASFLLCVLVNIGYHSLFTVSSGAGYQHLEAASTGISL
                     SFIASATVFGPILEEFVFRGILQGVVFENSWLGLVLTASLFSFLHAPYDFPSFIYYLF
                     GGFMLGFAYKKSQKLSVAILVYICYNCLSFL"
     gene            complement(21679..21783)
                     /locus_tag="VVO18_001217"
                     /pseudo
     CDS             complement(21679..21783)
                     /locus_tag="VVO18_001217"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_037603748.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
     gene            complement(22975..23184)
                     /locus_tag="VVO18_001218"
     CDS             complement(22975..23184)
                     /locus_tag="VVO18_001218"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000483697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEU5586382.1"
                     /translation="MFNYKIVDNQELSNISGGGLGGDVVVGALSGAFQAGQSCIAGGP
                     QAYLICATGGAIVGGILAYGLRPPK"
     gene            complement(23200..23448)
                     /locus_tag="VVO18_001219"
     CDS             complement(23200..23448)
                     /locus_tag="VVO18_001219"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Blp family class II bacteriocin"
                     /protein_id="HEU5586383.1"
                     /translation="MNTKMMSQFSVMDNEMLASIEGGTDWGTVGKGAVYGAGIGVAMC
                     AVGGLLTGGSTWAMTAGCAWAGAKLGGSFTAIADNLWP"
     gene            23723..24981
                     /locus_tag="VVO18_001220"
                     /pseudo
     CDS             23723..24981
                     /locus_tag="VVO18_001220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458604.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
     gene            24992..26353
                     /locus_tag="VVO18_001221"
     CDS             24992..26353
                     /locus_tag="VVO18_001221"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001069090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin secretion accessory protein"
                     /protein_id="HEU5586384.1"
                     /translation="MNPNLFRSVEFYQRRYHNYATVLIIPLSLLFTFILIFSLVATKE
                     ITVTSQGEITPTSVIASIQSTSDNPILANHLVANQVVEKGDLLIKYSETMEESQKTAL
                     ETQLQRLEKQKEGLGILKQSLEKATDLFSSEDEFGYHNTFMNFTKQSHDIELGISKTN
                     TEVSNQANLTNSSSSAIEQEITKVQQQIGEYQELRDTIVNKRARLPTGNPHQSILNRY
                     LIASQEQTQGTAEEPFLSQINQSIAGLESSIASLKIQQAGIGSVATYDNSLATKIEVL
                     RTQFLQTASQQQLTVENQLTELKVQLDQATQRLGNNTLTAPSKGIVHLNSEFEGKNRI
                     PTGTEIAQIFPVITDTREVLITYYVSSDYLPLLDKGQTVRLKLEKIGNHGTTIIGQLQ
                     TIDQTPTRTEQGNLFKLTALAKLSNEDSKLIQYGLQGRVTSVTAKKTYFDYFKDKILT
                     HSD"
     gene            26410..>26557
                     /gene="blpC"
                     /locus_tag="VVO18_001222"
     CDS             26410..>26557
                     /gene="blpC"
                     /locus_tag="VVO18_001222"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quorum-sensing system pheromone BlpC"
                     /protein_id="HEU5586385.1"
                     /translation="MDKKQNLTSFQELTTTELNQITGGGLWEDILYSLNIIKHNNTKG
                     LHHPI"
BASE COUNT         7840 a         5894 c         4758 g         8065 t
ORIGIN      
        1 tcacaaaaga caacattttt ttcaatgcca tcccatctgt ctgtcgaaga acttccaata
       61 tatttatttt tgggtaatct ttccatctca tattgttttt gaggagcata tggttcccaa
      121 taatctaatc ctttttttgt tccagaacgg cctttaagaa cttctacatt tctagaagct
      181 ttaacgttat aatatgaata gattaaacat tgtttcccat ccacttcatc tatttgatca
      241 acatttgtac taaaccaata ttcagacaca cttttattgg ctggagaacc atataaagct
      301 tgtaaaattg aagttttatt tactccatat ctattacaga cacctcagga ttatttaact
      361 tataagtttt aacagctacg gaatcaattt caacagcaac ttgaacatct atgcctgatt
      421 ttttaaggcc acttgtagtg ccacctgcac cgctaaataa atcaatagca acaattttcc
      481 ccatagtatt ctcctaaagt ttctcctttt tattataaca ttatcaaatg taaaacccaa
      541 cccgagaggg ttaggttttt aacatcattt caccaacttc ttcatctcat caatacgtgc
      601 tacggtcgca tcatacttgg cttggtagtc agcttgtttg tcgcgttctt tttggacgac
      661 ttctggtttg gcgttggcta cgaagcgttc gttagagagt ttcttaccaa ccatgtccag
      721 ttctttttgc catttagcaa gttccttgtc gagacgggcc agttcttctt caacattgag
      781 gagatcggcc agtggcaggt agatttctgc tcctgtgatg acacttgaca tagccagttc
      841 aggtgcaggg atggttgatg cgatttccaa atgttctgga tttgtaaagc gtttgatgta
      901 gttgacattg ctgttaaaga aggcttccaa gtcactatcg ctagtcttaa caaggattgt
      961 gataggtttg cttggtgcta catttacttc cgcacgcgca ttacgaacgg cacggatcaa
     1021 gtctttgaga ctttccacac cagtgtgggc agcaaggtcc tcaaaggctg ggttgacagt
     1081 tgggtatgct gctgtcacga tagagccttc agcgtactga ccaaagattt cttctgtcac
     1141 gaatggcatg attgggtgaa gaagacggag gattttatcc agcgtataga ggagaacaga
     1201 tcgagtaatg accttatcgt cttcattgtc gctgtaaaga acttccttgg tcaactcaac
     1261 ataccagttg gcaaattctt cccaaatgaa gttgtagagg atgtggccag caacaccaaa
     1321 ctcaaactta tcaaagttag cagttgcttt tccaatcgtt tcattgaggt tgtggagaat
     1381 ccagcggtcc gtcacattac cagcctcacc tgttgcaact tttgtgacat tgtcatgcac
     1441 cacatccagc gtcaaacctt cattgttcat aaggatgtag cgagagatgt tccagatctt
     1501 gttaatgaag ttccatgaag catccatttt ctcataagag aaacgcacgt cttgtcctgg
     1561 cgcagaaccg tttgaaagga accatcgaag ggcatcggca ccgtatttct cgataacatc
     1621 cattgggtca atcccgttac cgagagactt agacatcttg cgtccttgct cgtcacgaat
     1681 aagaccgtgg ataaggacgt tttggaatgg ttgacggcct gtgaattcca atgactggaa
     1741 gatcatacga gacacccaga agaagatgat gtcgtaacct gttaccaagg ttgaagttgg
     1801 gaaataacgt ttaaagtctt ctgagtcgac ttcaggccag cccatggttg aaaatggcca
     1861 gagggcagaa ctgaaccaag tatccaagac gtcttcgtcc tgagtccatc cgtcaccttc
     1921 tggagcttct tcgccgacat acatttcacc atcagcattg taccaggcag ggatttggtg
     1981 accccaccaa agctgacgag agataaccca gtcgtggaca ttttccatcc attgaaggaa
     2041 ggtatcgttg aaacgaggtg ggtagaattc gaccttgtcc tctgtgtctt ggttggcaat
     2101 ggcgttctta gccaattggt ccatcttgac gaaccattga gtagacaagc gtggctcaac
     2161 tacgacacct gtccgttctg agtgaccgac tgaatggaca cgtttttcga ttttgacaag
     2221 ggcaccgatt tcttccaact tagcaacgac tgccttacga gcttcaaaac gatccatgcc
     2281 tgaaaattca aaggcaagct cattcatagt tccgtcgtcg ttcatgacgt tgacttgtgg
     2341 caagttatga cgttggccaa ccaagaagtc atttggatcg tgggcaggtg tgattttcac
     2401 gacaccagta ccaaactcag gatctgcgtg ctcatctcca acgattggga tgagtttatt
     2461 agcgattgga aggatgacgt ttttaccaat caagtccttg tagcgcgggt cttctggatt
     2521 aaccgcaacc gcaacgtccc caaacatagt ctcaggacga gttgtagcaa cttcaagggc
     2581 gcgtgaacca tcttccagca tgtaattcat gtggtagaag gcaccttcca catccttgtg
     2641 aatcacctca atatcagaaa gggctgtgcg agctgctggg tcccagttga tgataaactc
     2701 accacggtag atccagcctt tcttgtaaag gtccacaaag accttacgaa cagcttttga
     2761 caaaccttcg tcaagagtga aacgctcacg agaatagtct acagagagcc ccatcttgcc
     2821 ccattgttcc ttgatggtag tggcatattc gtctttccat tcccagactt tcgtcaagaa
     2881 agactcacga ccaaggtcat agcgggaaat gccctcacca cgcaagcgct cctcaacctt
     2941 agcctgagtc gcaataccag cgtggtccat tcctggaagc caaagggtat caaaaccttg
     3001 catgcgtttt tgacggatga taatatcttg caaagttgta tcccaagcgt gaccaaggtg
     3061 aagtttacct gtaacgtttg gtggtggaat aacgattgaa taaggcttag ccttttgatc
     3121 gcctgaaggc ttgaaaacat cagcatcaag ccatttttga taacgaccag cctcaacctc
     3181 ggctggattg tatttaggtg aaagttcttt agacatgtgt gtgtcctttc tctattttgt
     3241 ttattttatt ttgaatttgc ttagcagctt cttctgcaga caaattcgta ttatttattt
     3301 taaagtagtg gttcaactca ttcggttgat gttgggaatt taattgaagt gtttcagcgg
     3361 tctctataat ttctctttca gatacctcaa tatgtcgttt taagggtttg tactttaatc
     3421 gattctccgt tcgatttcga cgtatgcact cttcaagact tgtttccaac tcaacaaaaa
     3481 gaatctcttg atgataatca tccaacaaac tctgaatttg ctttaaatat atcagatgat
     3541 actgatttga aaaatcaatt acatctgtta aaattactga tcgctgattt cttgcactcg
     3601 ctccaaggaa tgaaaaagtg attccacgaa caaattccca catttcctct gtatagtcct
     3661 gatagatttc tagtgcaaaa tcaatggctt gatggttata aaagagggta gcatccgtca
     3721 gtcgagataa ttcttgacca atggtcattt ttcctgatgc tggagcacca atgatgaaaa
     3781 gatgcatcaa atcacctccc actcactctt cagaaaggca tatctcaaat catcacagca
     3841 gttgccttga gcatctttgc ggtctcttat gcgagcttcg agggtaaagc caagtttttc
     3901 cgcgactcgt tgactttgaa ggttatatcc aaagcaagtt agttcaatct tgtgaagacc
     3961 caaatcttta aaggctaagt caatcaaggc acgcgcagct tctggcacat aacctcgccc
     4021 ccaatagtct gggtgtaagg tatagccgat ttccagcaca tcatcttcat ggcgatggtt
     4081 gaaatcgaca gagccaacga tcttatccgt tcctttgacg acaatcccgt agcctgctgg
     4141 gagattttcc ttttgattac gctccggaag aatgtgctcc agataataaa tctcatcttc
     4201 caaggtcttg actggaggaa aacctgctgg ataggcgacc tctggcaaac tagcatagtc
     4261 aaagatatcc tcagcatccg ccacagtacg gactcgtaaa acgagacatt ctgtttcgat
     4321 tttatctggt agctcagttc ttgccatcct tcttcctcgc ttttttgatg aaactgccct
     4381 tcatatctac acgcttgtcc agatagcgat aaacgcgctg atatccatct cccatgaaat
     4441 aggttggggc aaacagttga tttttaaaat gtcccttttc atccaggagt tctggaacaa
     4501 caagtcgctc aagaatcttg gcaaagatgt ggcaaatacc gtcttcctca acaatcctat
     4561 ctacccgaca atctaaaaca agtggacagg cgtctaaaat aggagtctga gttcgttcag
     4621 aaatttcata atgcactccc aaacgttcca atttctcctg atgactgata aaaccagcct
     4681 gctccatcgc aagcatagaa gtttcatcag aaatattcac agtaaatttt tgatactgtt
     4741 tgatctgctc tgcggcattc tctctcgcaa cgactccaat cacaacccaa tctcctagac
     4801 tataagagga actacaggtc gtgatgttat agccaaaatt ctaatcttga tatcctaaaa
     4861 taaaaacagg aaaaccataa tatagtttac ttgtgttaaa agattgcttc ataacaaccc
     4921 cctttgacta agacgtaaaa gaaaagccct gccatctaca tgacagggac gaatgtgttt
     4981 atccgcggta ccacccaatt tcgggcagtt gcccgcaact ctcgtcttta aagcaaaaag
     5041 acacttttat ttcaattttt catccattag caaccagttt tgacacattt gtggacttct
     5101 cagcgccgcc actttctgta aaatgtggga ttcaaaacac ctctaatggc tctattgtag
     5161 caagattttt tcggaaatgc aaggctcaag aaaaattact tgaacttgat gccattttct
     5221 ttcaatttct tgatggtagc tgggccgatt cctttcaagg caaggagttc tttttcagtc
     5281 cagtttttga aatctgaagc agacttgatt ccttcatcat agaaagtctt ggcacgatca
     5341 agtggaagtc cacccaaatt tgctgcaaaa tcttctacag aattagctac tttttgagct
     5401 tgctctttgg tagcttctac tgcttgttca acttttttag aaacagcctt accagctgcg
     5461 cttgctgact gttctgcacg cttcacgact ttttttgtct catctacaac cttagtcaca
     5521 gtacttgaaa aggcacctgc gcgacggagg ccatttcgta attgtttttt acgattgagt
     5581 ttctttgaca tgataaaatc ctttcaataa aaaatccctg ctctgacaag gatttaacat
     5641 aaacattcta tcaagatttt agtgaaaaat caagaatctt tctcgtttaa taatttcgct
     5701 caccaaacaa gccttctggc aaatcatgga atcccttgcc tgctttgaag ttttcaaact
     5761 taccaagcaa gaactgataa gcatccaagc gactctcgta gcgaatcatg gcatctttgg
     5821 cacgctcgtc ctggtcttct tcgtaaactt tttgactttc cttgtgcgcc atatcgttaa
     5881 tcatgatttg ggtattgacc caagcttcaa attccttcat aaattcttgt tcgtaactca
     5941 ttttttctcc ttattctaat ccacgaaaat agtccgtatc aatctcacgg tagggctgga
     6001 tatcctgaac atactccaac actccttgga attctccgtc ttcatcgtgt actgcagcat
     6061 aggtgatgtg gacaaactta cctcgcgact cagacttgaa ccacatttca tacttgtctt
     6121 tgcttccctc acgaagcccc ttcatgatag ttttgacctt gtccaagtac ttaggcggat
     6181 ggcagagttc gacattgcgc ccgacttggg acggcgtccg tttgaaaatc atctcatcag
     6241 ctggcgtatt gtcattgtaa tactggaaaa tatcttcttt attgacaaag gtaatctcca
     6301 tagggagatg attgaggatg agattggcct gctcgactga aagatagcca ttaccaaaag
     6361 cctgttgact atggcggtcc agcacagctt ccttttcctt aggggtaaag gtaatggtaa
     6421 aatggccttc tggcgtatct atgacttgtt gaacttgacc ttctgccgta tctagctgta
     6481 caggttcctc tgcaatcttt tcctcaataa agctctgtcg ttctggcacc catttctctg
     6541 acggacggat gatggcatag ccataggcat cgctctcctc cgcaatctga agccagtcat
     6601 cctgagtaaa agactcaagg agaatcatga ggaggatgga ctcttccttg aaaatcatac
     6661 tttcaaactc tgtcgcaaaa gcttcaaaag cttcctttac actgctaatt gacacttctg
     6721 gtagtgactt ggctgtcgtt agagctgttt gaaagagttc cctaatctga tcatccactc
     6781 cccacataac tttgggaggt gaatcgtgtc catagcgctc catgatagga aagaagagtt
     6841 cttccttacg ttggtaatgg atgtcaaatt gccccacaag ccccatctga cgcaccaagc
     6901 ccttgcgcat ctccgcaagc atttcctcgt cttccatcaa ctcataggta tctaacaatc
     6961 tacgaatgcg aatcaaagct gcacggagag ccagattttc ttctttgaag acacgaactg
     7021 ggtgacctgg atgctcagta tctgaaactt cgacaccttt gatagcattt ttaaaaagat
     7081 tggcatggac atcacagagt tccataacat cttcaaaagt gacgcccgaa tccgagttca
     7141 tcagctcgtg ctccataagg gaaatctcga tggctgacac gcccgtaaag gtcgcatcaa
     7201 agcgatcttg aaccgactca ggagaggcgc cattgtgcaa ttctaacaaa atatcccgta
     7261 ggacatgaat ccgttcatct gccattagtc taatccaatc acttcgtagc cattcgcttc
     7321 cagtgtgcgt acaatcttgt ccataggagt tcctgctagc ttagaaccct gtttaagtga
     7381 tactttacga ccaactgtat tgcgcattaa gggattggca aggggtttaa aacccaactc
     7441 cactagaatt tccaagactt ctggatgctt gtccaccact tctgcaacag gaattgacac
     7501 atcgatgata ttgtccatga cgacctccat tgtatgttct aatactcaat gaaaatcaaa
     7561 gagcaaacta ggaagctagc cgcaggttgc tcaaaacagt gctttgaggt tgtagataga
     7621 actgacgaag tcagctcaaa acaccgtttt gaggttgtgg atagaactga cgaagtcagt
     7681 aacatatata ctgcaaggtg aagctgacgt ggtttgaaga gattttcgaa gagtataaaa
     7741 tgattttact gcttatatta taccatatgg aaagagaata aaaaactagc agtggagttc
     7801 ctgctagttc tctgcgactt ggattaccat ctagataagt ttaaagagcc aatccaatat
     7861 cttaaacact atcttgtaaa acagcaattg gactgcaaaa gagatgatca tccaaaagaa
     7921 tttcacaatc ccaataatcg gtttgataaa aataatggca agaagtcccc agaaaaattt
     7981 cattttttat cctctggctt aatgagccac cgagccgtat ccattagctt atctgcaata
     8041 aagagttttc ccagaccaac aacgacatgg tcatctttct ttatcgtttt cattactttt
     8101 acaccttgca cggtcaaaaa gtaattacca taaattttag ctagagtttt tatgagtccc
     8161 atattactct ccttcgatga tttcagcctc ttttcggatt gtttcaacat cttcttgata
     8221 ttgaacttca ctatagttaa ctagcttgga caattctttc tgcaagcttt cacccatcgg
     8281 tttcatagtt gcaaaggtta aaccacctga aatgatacca cccaagatag gaataaattt
     8341 ccccattcct ttggccagcc ctcccttggt aagattcaca ccaaatattc ttaagacttt
     8401 tttcaaaata ggataccaaa gcgtctttgt taaagcttta ttaggtactg ttttcattac
     8461 ctgtttggca attgttatac caccagcacg tagcaaagca gcagttccat tcacccccaa
     8521 catgacgcct agataaagca agagggtatt ttgagcatct tcacttaact cctcacgtga
     8581 agtccaaaga gcctcataac cataaatata acctaattct tgagccaatt tcagagagaa
     8641 agcataaaat tgagccacat cagctggaat ggtaattgcc atagcaagcc ctccaggtaa
     8701 tcctgccaaa acagaagtcc cactcgctaa taatacattg tcccgaatac aagcattagc
     8761 tacacgatct aatatttctt gagatagaag agtcgttgga ccttgttcca ataaggtagg
     8821 aatatctttt ggatccaatt ctttggaaaa cttatccact aaaaatttcg aacgatcaac
     8881 cttaacaaca ggtagtttca ccacttgttg caatacttgc atagctaagt cttgttcagc
     8941 catatacaaa ctccttattt cttttttgca ccttatcata ttatatttcc tacaaaaaaa
     9001 gcattttcta attagataac attaaaaaat acagaacccc ttttttatat taaaatgaaa
     9061 caagaacagg acaaatcgat caggacagtc aaatcgattt ctaacaatgt tttagaagta
     9121 gaggtgtact attctagttt caatctatta taaaagaata tttttccatt tcaaattcaa
     9181 cctattttcc tccaccaaaa aagaggggca acccctcttc tttagttctt atccagattg
     9241 cgtagcatct cgtcaatctt gtttccatac tcgatggact cgtctttgac gaaggtcaaa
     9301 tctgggattt tgtacaattt caaattgcga ccaagttcac gtttgatggt accagttgct
     9361 ttttcaagcc cgatttgggc tttttggtta tccgaagcaa ggttactcaa aatggtgtaa
     9421 taaaccttgg caacagacaa gtcacccagc atctgaacat ctgtgatggt cacaccttgg
     9481 acacgtggat cacggacttt cttttgcaaa atctcattga cttcacgctt gatttccatg
     9541 cccacacgat ctgtacggaa atgatttgcc atgatattcc tttctctact ttgaaccaaa
     9601 agctaggcca gcagacctag ctattttaaa cttcttgatt ttcagtttaa attgaaacga
     9661 agttcaattt gaagtcatct gcttctttcg ccgtggtgaa agtgatggaa ctgatttatc
     9721 agtcccatca caggggattt ttgagaccct aggctcaaaa ataagcaatg aaaccatcgg
     9781 tttgcttgcg tccctcacca cctaagaaag gagcaaaaaa tcttatctct tgatttcttc
     9841 catgacatac gcctcaatca catcatccat cttaatatca ttgtagccgt cgatcatcaa
     9901 tccaccttca cgaccgtttg tcacttcttt cacgtcgtct ttatagtgtt tcaagcttgc
     9961 gagttcacca tcatagataa cgacaccatc acggataaca cggactttag agtcacgggc
    10021 aaccttaccg ttgataacca taaatccacc gatagttccc actttagaca ccttgaaggt
    10081 ttcacggata accgcttcac caataacttt ttcttcaaat tctggatcaa gcatcccttt
    10141 catagcttct tccatctctt cgataacctt gtagataatg ctgtgaagac ggatttccac
    10201 atcgtcagct tctgcttgtt gacgagcttg tggtgtaggg cgtacgttga aaccaacgat
    10261 aaaggcattt gaagcttcgg caagggtcac gtctgattcg ttgatagcac cgaccgctga
    10321 gtggacgata gtcactttga caccttccac gtcaatcttt tgaagtgagg cagaaagggc
    10381 ttcaacagaa ccttgtacat cagccttgat gataacatta acagatttga gttccccagc
    10441 tttaagggta tcaaagaggt tttcaaggct aacacgttgg gtagcttgac gttgtttcat
    10501 gagggcacgt ttggcacgct cttcacctgc tgcacgcgca gatttttcat cctcgtaaac
    10561 ggcaaagtgg tcacccgcca tcggtgcttc gttcaaacct gtgatagaga ctggtgttga
    10621 tggtccagca actttaacac gacgaccaag gtcgttggtc atagcacgga cacgaccgaa
    10681 ggtatttccg acaacgattg ggtcttgaac attcaaggta ccttgttgta caagaagggt
    10741 tgcgaccgca ccttttcctt tatccaagcg cgcttcgata accgtaccga ttgcacgcac
    10801 tgttgggtct gccttgagtt cttggatttc agctacaaga aggactgttt ccaacaattc
    10861 ttcgatattt tggttgaatt tagctgagat ttcaacaaat tcagaatctc caccccaagc
    10921 ggttgacata actccatgct ctgccaattc accgataacg cgttctgggt tagcacctgg
    10981 tttatcaatc ttgttaatgg ctacgatgat tggaacgttg gccgcttttg agtggttaat
    11041 ggcttcgata gtctgaggca taaccccgtc atctgccgct acgaccaaga tcgtaatatc
    11101 ggtaacagaa gcaccacgcg cacgcattga tgtaaaggcc gcgtgtcctg gtgtatcaag
    11161 gaaggtaatc ttcttaccat tttccacgat ttggtaggca ccgatatgct gagtaatacc
    11221 acctgcttca cctgtcgcaa cacgtgagtt acgaagagta tccaaaaggg ttgttttacc
    11281 gtggtcaacg tgtcccatga tagtaacaac tggtggacgc tcaaccaatt catcttcatt
    11341 gagataacca tcttcgacaa agaaacgttc gatgtcagca ttatccactt caaccttttg
    11401 tttggcttcg ataccgtaat ccaccatgag gagttcaatt gtttccccat ctaaggattg
    11461 gttttgtgtg gccatgacac ccatcatgaa aagtttctta acgatttcag ctggttcacg
    11521 tttgatacgt tttgcgattt ccgcaacggt cataccatct gtatattcaa attctgttgg
    11581 caattcatgg aatttacgct ccgtaacagg ttttggagtc tgattacggt tgttcttgtt
    11641 attgcctttt ttgttctttt tgttgttatt ccagttacta ttcttttgat ttctcacttg
    11701 attttgacta cttcgattct tttgttgttt tctaggacca tcttcttcat gatcataatc
    11761 gtcacgattt ttgtctggtc gagcttgttt tttacgacgt gtatccactg caggttcttt
    11821 tttctcaggg acgacttcaa ccactgcttg aacttgctgt gcttgttcag ctaacttagc
    11881 cgcttcttca aagatttcct ctggttcctt gcgtttgtta gcttgagcca aggcttcttt
    11941 agcagcctga tactgcttga agcgttcctc acttgaacga gcgtactctg cattttgctc
    12001 tgcttttagg gctgctgcac gggctttaaa gtcaatacgt ggagccgctt gatttgaacg
    12061 tttatcctct tgctgacggc gctcatttct acgtttttgc tgaccttgct gcttcttagc
    12121 ttggtcatta aagcgacgat tgtcgcggtt gctttgacct tgttttccac cattacggcc
    12181 gtcgtttttc tgacggtttc cgttttgttg ttggtcacgg ttattgccct tattttgctt
    12241 gcgtcgttct gcctgctctt tagcacgggc ttcacgctca gccttgaaat tacggctttg
    12301 cggtttcgct gctacttttt ctgttttcgg agcaactggc tcagccggtt ttgcctcttc
    12361 cttagctaca gctggtttag ctggctcaga tttttcggct ttcttttctg cacttacttt
    12421 tggtgctgca ggttttgctt ctactttcgg agcagctgca ggcttaaagc tggcagcaat
    12481 ttttgcagcg acagcttctt ccacacttga tgagtggctt ttcacatcca agcccaactc
    12541 ttttgcacgc gctacaactt ctttactttc ttttccaagt tcttttgcga tttcgtacaa
    12601 tcttttctta gacaaatcat gtcctcctct tctattccat aagagacctc attttctttg
    12661 taaatccagc atctgttaca gccaaaacct ttctcgattt cccgactgct atgcttaatt
    12721 ccagtgttga aaacacggtt acaatttcta cttgataata atgactttta tcttgaatct
    12781 tcttggtcag attgggtcca gcatcatgag ctagaaagac caacttggcc ttgccgtctt
    12841 gaatggcctt gaccaccaat tcttcacccg atatgatgcg ccctgctcgc tgagcaagcc
    12901 ccaagagatt acttatcttt tgcttattca agtcccaact ctcttctttt cactttgtga
    12961 tccacataag cgatcaactc gtcataaaag ctttcttcca cttccatgct aaagctgcgg
    13021 ttaaagacct tcttcttttt cgcctctagg gcttctgcat tgtctagttt gatataagcg
    13081 ccgcggccat tggccttgcc cgtaggatca ataaagactt gtccttcctt gttcttgaca
    13141 atgcggagca aatcacgctt atcaatcact tcgttagaca caacagactt gcgcaaaggg
    13201 atttttcttg ttttcatctt tccctcctct agcagctttt attcttctac agtatcgttt
    13261 tctacttcca actctactga agcagcgtct tccatggctt caaattcgct agcagacttg
    13321 atatcgatac ggtaaccagt caagtgagcc gccaagcgca cgttttgtcc acgacgacca
    13381 atggcaagag aaagcttgtt atctggaaca accaccaagg cacgtttgct gtcgttttca
    13441 tcaaagataa cttggtcaac ctcagcagga gcgatggcat tgtagataaa ttcagctgga
    13501 tctgctaccc actcgataac atcgatattt tcttcgattg gtaccatgcg gtcattttta
    13561 gcatcgtaac gagctgggtg gaatttgcta gtaatcttct tgatattagc accaccacgt
    13621 ccaacgattg taccgatagc atccacgttt ggattgtggc tacgaacagc aaccttcgta
    13681 cggtcacctg cttcacgagc cacgctcatg atttcaacag ttccatcata aacttctgga
    13741 atttcttgct ccatcaaacg tttgatcatt tctggatggc tacggctaac aaagacgttc
    13801 acaccacgag ggttgtcttc aaccttgtaa acataaactt cgatacgatc atgagaagca
    13861 aaaacttctc caggaatttg gtcttgtttt gacaattggg cttcgatgct accaaggttg
    13921 acatagataa agcgattgtc aaagcgttct actgtaccag acatgatttc ttgctcatgt
    13981 tctttgtaag tattgtaagt gatggcacgt gtttgcttgc gcattttttc catgatggtt
    14041 tgtttggcag attgggctgc tacacgacca aactcagctg gtgcttcttc aaacttgatt
    14101 ttgtctccaa gttcataagc tgaattaatg gcaagagcat ctttcaaact gatttccaaa
    14161 cggctatcaa atacttcatc aacaacttca cggacagtat aaactgtaaa gtcacctgtt
    14221 ttttcgttga agtcaatagc tacgctgtct gactgaccat agcgtctgcg ataagcggaa
    14281 cgaagcgact ctactactgc gtcgatgata tcttcttttt tgattccctt gtcttcttcc
    14341 aaaatgcgga aggcctctag catttcttta ctcatgtttt cttcactttt gaatcctcaa
    14401 aagctatcct ttctttttct ataatttaac tgctaaacgt gcttttgata ctaaactgta
    14461 tggaatttgg acggttttct tacgcgtctt gtccatatat tccatagtca actcgtcctc
    14521 ttcgaaggcc aacaaggttc cttcaaagac cttttgctta tcgatggctt ggtagagccc
    14581 gacatggatg tattttccaa ccgctccagc gacggcatcc ttggttttca aaggacgttc
    14641 caaacctgga ctggtaattt ctaggaaata ttgttctggg aagggatctg gcttgatggt
    14701 gtctaggaca ggactgatca tttctgtcaa gtctgccgtg tcgttcaagg taattccttc
    14761 gggtttatct acaaaaatac tgagaatcat gtcactgcca atctttccat actcgatatc
    14821 cacgagttca aaaggagctt ctatgacagg ttctacaact tctctgacta attctacgat
    14881 tgttgcgatt gcgtccacct cctcataagc aagaggcgaa gatatttccc cgcctcactt
    14941 ttcatattct tactatcagt atagcacgtt tgccaactta tgtaaagcaa aagcacttgt
    15001 acagcctaat tttaggttat ctcttaaaat tctgcctcaa ctcggtagat aacttgcccc
    15061 ttgtttgaga atttttgctc gtattctgtc atgacattgc cttcaaaatc actggcatgc
    15121 aaatctaacc agacaccatt gagtttcatg ccatattgag aaaagctcac taaactgtac
    15181 tcaaacaagc cacggttatc cgtcttgaaa tgaatttctc cattttcagg caagatacgt
    15241 ttgaaggtat ccaagaaggt cttgtaggtc aaacgacgct tttcatggcg ttttttcggc
    15301 catggatctg aaaagttcag atacaagcga tcaatctcac cgtcttcaaa gtagtcagtc
    15361 aagtcagaac catctaccca caagagcttg atgttagaca ctccagcttc aagcaccttg
    15421 tccaaagcgt agctcaaaac agacttttga atatcaatcc cgatatagtt gatgtcaggg
    15481 ttttgcttgg ccatacctga aacaaaggca ccctttccac ttccaacttc cacatgaatg
    15541 ggattatcat tgccaaacaa gtcccgccat tttgccttgg cttccaaggg attgaggacc
    15601 acatactggg gatttgcctc tagtaattct gttgcccctt tacgatttct aactctcatc
    15661 ttctctttcc atacttgtct cggaaatgac gcaaaccatg aatctcccga ttgacatttt
    15721 ctaaatcttg gttcatataa tacttggaaa tctgactcaa ataagacaat tgaccatacc
    15781 aatacaattt acttaatacc gtttgattgt acttgtaacc gtagtaggtc aaccattcct
    15841 tccactgatg ttctgaaata taatggcaga gcatatgggc cacatcaaac atgcgatcgg
    15901 tcaagcgaac cgaatcccaa tctactaaat aaatcaagcc actatctgtc tcaatccaat
    15961 tactatgtcg tacatctcca tggacaatgg tcgcatggtc ctctctaaat cctggaatag
    16021 tctgacgtaa atcagccatc acttcactga taaaatgatt tttacgcaaa gcatctggag
    16081 ccgtttcttg ccaagactgt agtaaatcta caggtgtttc catggcatag cccaaacgac
    16141 tcaattgtgt catcaacgga cgtgagcgat gaagacgggt taaaatattg acgatttgct
    16201 tacgattcat atcatagggg gtcaatatct tgcctgtcaa ccattcttga gcacacatat
    16261 cacgcccatc tgccaaacga cgactccata ataattgtgg agcaatttgt tctctagcta
    16321 gaccaggtag gattggagag gtgttcattt ttacaaagat gcgcttccca tcaggatagc
    16381 tacccatata agccttgcca cttttcccag gtatgggagt cagtgttagc tcattatcac
    16441 ccaaatccat ttctttcctc cgtataaagt ttccttacta ttctactagt ttttggccta
    16501 ttcgtcaacc actctaaccc gattctcaaa gaaaagcctc tggattggct tgggtatcat
    16561 tatagcttga aaaaggtaag caccgtcttc tgcttacctt ttcataattt ttataaataa
    16621 tataggagtg gccaactgtt gtaaaacatg tggactagag tagaaaccca taagttttgg
    16681 ctctttttat aagcaaggcc cagcaacaag cccccaagta gataaaaaat aaacgaaggg
    16741 acattagaag gtccatgcat gaaagaaaag agagaggaag ttagcacaag tcctaaccaa
    16801 gaattgtcaa aaaccgcacc ttgaagaagt cctctgaaaa tgagttcctc ctggatgggg
    16861 ccaaaaactg aggtagtcaa aatcaaagac agggaaattc ctctgctgac ttccgccaag
    16921 tgttggaccc ctgagccaga agaaacagcg aagaaatgaa tataaaccag cgtctcaagt
    16981 acacttagaa gaaagattgc aatgaaaagc aaaagttgtt tcttgcttaa catcccaaaa
    17041 gaaatcattt caaactttct agcataagca acactcagcg aggttacaag aagacttaca
    17101 ataatcaatg cagattcatt ttgaaaaaaa tccccatggt taatcgtata aggaactgta
    17161 atgacaatta ttagtactaa aaatccaaaa cacaaggcat gaaatttatc aaaaaactcc
    17221 ataaaattat cctcctcaac aaacagactt cctacacgtc attctttagt tctagccttt
    17281 ccaaaacaaa ccattttata ctcttcgaaa atcaaattca aaccacgtca acgtcgcctt
    17341 gccgtactca agtacagcct gcggctagtt tcctagtttg ctctttgatt ttcattgagt
    17401 attagtaacc aaaatccgac cacatagcca gcccctatga atatagccat taaagctagc
    17461 atggaattta ggaaattaaa aaccaccgca gatacaaagg ttagcacaaa aacattaaaa
    17521 gcaatggtgt cagaagccaa gactagaata tagggtgtca accgatctaa agttttggaa
    17581 tctaggaaaa ataagtgttt atacatgatg acctcctcta tggctgaaaa gcaagccttt
    17641 tgttttttta ccccaagacc ctatgtagaa aagtgagcaa aaacgggaag gtcgctacaa
    17701 tattattgat cacatgcacc gcataggatg gataaatact cttggtatag cgggtcaaac
    17761 cggcaaagat gattccaaat gttgcaaaga cgaagatatc taacagacta ggcagactca
    17821 aaaaatgagg aagagcaaac aaaatggaag gaagaagcaa atcaaggcca aatcgcgaat
    17881 gcttaaagaa ggcgtgttga agtaatcccc tataaatcaa ctcttccatt agtggagtca
    17941 ggaaaaacag ggttacatag atacctagct cagcaaagtt ggtcccacta taacctatca
    18001 atacagccca accttcagca gttgactgaa catgtttagc tgtctgaacg ttaaaagaga
    18061 tctggagcac taccactaat actgtcaaaa tcgaatacca aagccatttt tttcttggaa
    18121 tgtgaaagag ataaccatga cctgtcttaa ccagaatcca aatcatgact ccgctaaata
    18181 gcaaactcaa gaaattttga atccagacga aattgccaat ctgggaagaa aattgccaat
    18241 aattttgaat aataagcgtc atctgagaaa gaccaaatac gaaaaataag taagagaaaa
    18301 ctgcacttat tttgaataga agttgatact ttttcataga aattcttcct catttcttgt
    18361 atttcagcct atattccaca taaatgaaaa cctgctccta tataaccacg gtcatgataa
    18421 ccgcgcgggc agtaaccact tactggaaaa ggacctgaat tttttaatat aggagggtaa
    18481 gaaccgaatg gacttacctg attagcgtac cctctataaa tatcagatac atccccaccc
    18541 tctatacgag caagcatttc attatccata actgcaaatt gtgacatcat ttttgtatcc
    18601 atatagtata tcacttttca gttacggaac aagtttaata taaaaattat caaaaaaaca
    18661 taggcaataa agagaaaaat taatttatca tagattagaa ataatatgac aaaacaattc
    18721 aatgatgtta attcaatagt cttttgtttt ttatcggaga tacttatgga tagataaata
    18781 agataggttt gaaaagcgaa gagaataata aagaatatag ccttcataaa atttagcttt
    18841 catttttatg atgtagcggt ataggctaaa tatccacaaa ccactgctcc tccaattcct
    18901 cctattgcag cgccccatgg tcctagaagt ctcccatatt tcactccacc cgctgcacaa
    18961 ccaaaagcag caccaccacc ttctaagaca ttagtttgcc aattattctt gcctccttca
    19021 atactagata acatagttat atccatttca tgaaattgtt ccataatttt tgtatccatg
    19081 acaaatactc ttttttattt ttaatttttg tcttgttgta actttgacaa gtttagtata
    19141 tcatcgtttt ttaaaatttt tcatccagat cttgaatagt catcgaaacg tcttgaattg
    19201 caaaaattac attagacttc ctgcaaaact agaatcctag ttcatgattg ataatgccag
    19261 caatcaaatt cattcgtaat ccgaagcgtt tacgatgatt tcgataggtt gttgaaaaca
    19321 ttttaaacgt ttttactttg gcaaggatgc tctcaacctt gcttctctcc ttagataacg
    19381 catggttata ggctttatct ttaactgtta gcggtttgag tttgctggat ttacgtggag
    19441 tttgtgcttg aggatatatc ttcatgagcc cttgataatt actgtcagcc aaggttttac
    19501 cagtttgtcc gatatttctg cgactcattt tgaacaactt catatcgtgg caatagttca
    19561 cagtgatatc caaagaaaca attctccctt gacttgtgac aatcgcttga gccttcatag
    19621 cgtgaaattt ctttttacca gaataattgg ctagttgatt tttttaggac gatttatttt
    19681 tacctctgtt gcatccacaa tcaccgtatc ctcagcacta agatgagttt ttgaaatcgt
    19741 aacaccactt tgaacaagag ttacttcaac ccattggctc cgacggatta agttgctttc
    19801 gtgaatacca agatcagccg caatttcttc ataagtgcgg ttctcacaca tattgaagag
    19861 tggccataag aaggtcttct aggcttaatt taggttttcg tccacctttt gcgtgtttaa
    19921 gttgataagc tgtttttaat acagctaaca tctcttcaaa agtggtacgc tgaacaccaa
    19981 caagacgctt aaatcgtgca tcagttagtt gtttacttgc ttcataattc atagaactat
    20041 agtaaaatga aataagaaca ggataaatcg atcaggacag tcaaatcgat ttctaacaat
    20101 gttttagaag tagaggcgta ctattctagt ttcaatatac tatactatac catattttgt
    20161 ttcgcaggga atctattata aaagggtaag tattgcgaaa acacttaccc ttttctttta
    20221 tacttcatta agctctactt tttataatac ttcaaacccc aaatgagcaa aagcatgata
    20281 agcaagcaga gaaccgcgcc aatataagcg attatttgtt gataggattc tgctgctgtg
    20341 atccctctat acaaacatat aatagacata aaacctgtca agccgataaa catgagttga
    20401 ttggttctag gactaaccaa atcatcatct tcaaactttc ttatcctcat ttccctagtg
    20461 agataaacag tagccaaaat agaagccaag ttaataatca ctaaaagaaa ttggaaaacc
    20521 aaggaaaaat ttaaaaactg acgagataga aatagataag tagaaacaac caaaggtatc
    20581 tgtcctaaca acaacctcac taagaaaaca ttgcgttttg ttgcaaatat ttttttcata
    20641 cctaaactcc attacaatta aatgatatct aatcattttc taaaatttga taacttttgt
    20701 gagatgtttt agcagaaaca actctatgat tggtgatatc tagataatca cctgggtaac
    20761 caagaacata cataccataa ccagcgaatc ttcctccaac tgttccaacc agaccaaact
    20821 tgatattagt tgtgagagaa gtattaagag ccgccataag aatgcgcaca tgattatcca
    20881 accaaaccat ataatttttt gaaaagctac ctcttcccaa cctcctaaac ctccttcaac
    20941 tttcgcaaaa atttcggtat ccataatctc aaattgtgac atcatttcat ttaatgttgt
    21001 taatctaaac agtaatagta tccatttccc tattttttaa gattttttgt ccaatattat
    21061 gtcatattga ttacttacat atactacagg aatgataaac agttataaca gatataaact
    21121 aaaatagcca ccgatagttt ttgactcttt ttataagcaa agcccagcat gaaacctcca
    21181 aatagataat agataaacga aggaaaatca taaggagcat gcaggaaaga gaagagagag
    21241 gcagtcagta caagccccaa ccaagaattt tcaaaaacca caccttgaag gattcctctg
    21301 aaaacaaatt cctccagaat agggccaaaa actgtcgcgc ttgcaataaa ggataaggaa
    21361 attcctgtac tagcagcctc aaggtgttga tatcctgcac cagaagaaac tgtgaaaaga
    21421 ctatgataac ctatatttac cagcacgcaa agaagaaagc ttgcaataaa aagtagaact
    21481 tcttttttcg ttaaccttct tagcgaaatc atatcaaacc atttcgcata ggcaacactc
    21541 agtgaaatca agaaagtctt tgcaataata aataggtgct cgttttgaaa ataatcacct
    21601 tgattgatgg tatagcctac tgtagcgact attacataga ctaaaaatcc aacaaacacg
    21661 gcatgatatt tattaaacag gtttgagtcc tacgcttaaa taagcttcaa tttctcctct
    21721 ttcagcttca gataagtgat tgtattattg atttgtggta gaatagtttg tggacatgtt
    21781 catcttcctt tatactgttt ttcgcaactc tagtatatca gatgaacatg tcttttgtgt
    21841 tgcacttcat tttacaacag agcgaatata tttagttgta aaagtaccaa ttatgatatt
    21901 tttcgctctg cagaatagaa atatcatttg ctttcaaaat aatgattaac acaatcatat
    21961 ttatttgtta caaagatttc ttaactaact cctctctcag gctacataag cgttctattc
    22021 gtgtgtcctt ttttttatga acaatagtca ccgtttatat tttcatacta ccatcctatc
    22081 aaacaaataa tcaaaacaga caattctact ttcaattgtt caccccttcg ctccacttcc
    22141 actacagaag tttcctcact actatgggtt cggctgactt ctcatgattc gttgttacta
    22201 cgcttttagc gctcatgaga cctcacggga taagtcgtac atctttcctc gtgtatacaa
    22261 gatatgagga cgttaaaagg ttacagtgaa aataggaaat ctgacgcaga gtctttagac
    22321 tctagaaaga tttatctttt tcacacaaac cttagtccga attcaattac tctcgtgatt
    22381 tacgcatata ggttacgact acctttttgg actttagagt ttgaggcccc cttatccgct
    22441 atatacgcct tactatcacg ttcctgttcg tagagccacg atttcgctat cccttcctct
    22501 ccctgctacc tcacgatagt caggcttggg aatcgctatt gggttcaccg gtagcaggtg
    22561 cccaccgagg acttacacct cagatatacg acatgcccgt cgtacatcaa aaaagaaagg
    22621 acgaaattcg tcctttctcg atcttagatt ttcttcaact cactacagtt gacaatgagc
    22681 caaaggatag ctaataacct attgaagtgt caaacgttgc taactccatt tatcttcaaa
    22741 tttaaatagg cacattatcg gagttatcag taagaaaaaa tctaaccagt tcagataatt
    22801 cataatatag gatataatac cagccataac gaaaaggtac aaagctgtac gatatcctct
    22861 cttttggttt ttatcagcct tggtgttaaa aataatgtac acacaacaaa ttgcaatgag
    22921 tacaagctga atcatagttt catttaacat attaacactc attccttttt aaaactattt
    22981 tggtggtctc aatccataag ctaaaatgcc acctactata gcgccccctg ttgcgcaaat
    23041 caagtaagct tgagggcctc cagcaataca agattgtcct gcctgaaatg cacccgacaa
    23101 ggctcctaca actacatctc ctcccaatcc acctccagaa atattactta attcttgatt
    23161 atctactatt ttgtaattaa acataatttc tattcccttc tatggccaaa gattatcagc
    23221 aattgcagta aaagaaccac caagtttagc tccagcccaa gcacagccag cagtcatagc
    23281 ccatgtggaa ccaccagtaa ggagtcctcc taccgcacac atagcaactc cgatacctgc
    23341 tccatagaca gctccttttc ctactgttcc ccaatcagtt cctccctcaa tgctagccag
    23401 catttcatta tccataacag aaaattgtga catcattttt gtattcatga caaatactcc
    23461 ttttttattt ttgtcttgtt gcaactttga caagtttagt atatcatttt ttttttaaat
    23521 ttttcatcca aatcttgaat tgtcatcgaa acgtcttgaa ttagcttttc atttgaaacc
    23581 acctctaaat gtttaaaaaa aaaataattt ctaatcactt ttttaccatt caggaagttt
    23641 caatgactat tcaagattta ataaaatatg aacttatttt tatggcataa tatacctatc
    23701 tactatatga aaggaattgc caatgacttc ttataaacgt acatttgttc ctcaaataga
    23761 tgcgagagac tgcggtgttg ctgccttagc ctcgattgct aaattctatg gttcagattt
    23821 ttctctagct cacttgagag aacttgcaaa gaccaataaa gaaggaacga ctgctcttgg
    23881 cattgtaaaa gccgctgatg aaatgggctt tgaaacaaga cctgttcaag cagataaaac
    23941 tctctttgac atgagtgatg tcccctatcc atttatcgtt cacgttaaca aagaagaaaa
    24001 actccaacat tactatgttg tctatcaaac aaagaaagac tatctggtta ttggtgatcc
    24061 tgacccttct gtaaaaatca ccaaaatgtc aaaagaacgc tttttctctg aatggactgg
    24121 agtagctatt tttctagctc ccaaacccag ctatcaaccc caaccaaact ccaatctgcg
    24181 aaggtcgcta ataaccgttt gaacgaagtc tatctagtcg aatctgaatt tcaagttcaa
    24241 gaaaaccctg ttcattcaca ttttttgatg ggcgatattg aatttgatga cctttcttat
    24301 aagtatggtt ttggacgaga taccttaaca gatattaatc tcacgattaa acaaggagat
    24361 aaggttagcc tagttggagt tagtggttct ggtaaaacaa ctttagccaa aatgattgtc
    24421 aatttctttg aaccctacaa agggcatatt tccatcaatc atcaggatat taaaaacatt
    24481 gataaaaaag tcttgcgccg tcatattaat tacctacccc aacaagccta tatctttaat
    24541 ggctctatct tggaaaattt aaccttgggc ggtaatcata tgattagcca agaagatatt
    24601 ctaagagctt gtgaattagc tgaaatccgt caagacattg aaagaatgcc tatgggctat
    24661 caaactcagc tctctgatgg agctggtcta tcaggaggac agaagcaacg aatagccctc
    24721 gctcgtgctc ttttaactaa atctcctgtt ttaatactag acgaagctac tagcggtctt
    24781 gatgtcttga ctgagaaaaa agttatagat aatcttatgt ccctaactga taaaaccatt
    24841 ctctttgtag cccatcgtct cagtatagcc gaacgaacta accgtgtcat tgttcttgac
    24901 caggggaaaa tcattgaagt tggtagtcac caagagttaa tgcaggcgca aggcttctac
    24961 catcatctgt tcaataaata aggagaatgt catgaatcct aatcttttta gaagcgtcga
    25021 gttttatcag agacgttacc ataactatgc gacagtatta atcatacctc tttcattatt
    25081 atttactttc atcttgattt tctcccttgt tgccacaaaa gaaattactg ttacttccca
    25141 aggggaaatc acccctacaa gtgtcattgc atctattcag tcgaccagtg ataatcctat
    25201 ccttgctaat catttagtgg caaatcaagt agttgagaaa ggtgacttac tcatcaaata
    25261 ctctgaaaca atggaagaga gtcagaaaac tgccttagaa actcaattac aaagacttga
    25321 gaagcaaaaa gaaggacttg gaatcttgaa acaaagctta gaaaaagcga ctgatctttt
    25381 ttctagcgag gatgagtttg gctaccataa tacttttatg aattttacta aacaatccca
    25441 tgatattgaa ctgggtatct caaagactaa cactgaagtt tcaaatcaag ctaatcttac
    25501 caatagcagt tcatcagcca tcgaacaaga aattacaaaa gttcaacaac aaattggaga
    25561 atatcaagag ctgagagata ctatcgtaaa taaaagagct cgcttaccaa ctggcaatcc
    25621 gcaccagtca attttaaatc gttatcttat agcctctcaa gaacaaacac aaggaacggc
    25681 agaggagcca tttttatctc aaattaatca aagtattgca ggtctggaat catctatcgc
    25741 aagcctcaaa attcagcaag ctggtatcgg aagtgtagca acttatgata atagtttagc
    25801 aaccaaaatt gaagtactcc gcactcagtt tttacaaaca gcctcacagc aacaactaac
    25861 cgtggagaat caattaacag aattaaaagt acaactagat caagcaacgc agcgcttagg
    25921 aaacaatacc ttaaccgctc caagtaaagg tatcgttcat ctgaacagcg aatttgaagg
    25981 taaaaataga attccaactg gtacagaaat tgctcaaata ttccctgtca tcacagatac
    26041 aagagaagta ctaatcactt actacgtatc ttctgactat ctacctctac tagataaagg
    26101 acaaactgta agattaaaac tggagaagat tggaaatcac ggcaccacca tcatcggcca
    26161 acttcagaca attgatcaaa ctcctaccag aacagagcaa ggtaatctct ttaaattaac
    26221 cgctcttgca aaactatcta atgaggatag taaactcatc caatatggct tacaaggtcg
    26281 cgtcactagt gtaactgcaa agaaaacata ttttgattat ttcaaagata aaattttaac
    26341 ccattctgat taattttcag ataacactct ataactattt attatcttat caaaaaggag
    26401 aatcataaca tggataagaa acaaaaccta acttcatttc aagaactaac aactaccgaa
    26461 ctcaaccaaa ttacaggtgg aggactgtgg gaagatatct tatacagcct taatataatt
    26521 aagcataaca atacgaaagg acttcatcat ccaatac
//
LOCUS       DAVHIZ010000028        23080 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.030, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000028 DAVHIZ010000000
VERSION     DAVHIZ010000028.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23080)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23080)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23080
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.030"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(86..235)
                     /locus_tag="VVO18_001223"
                     /pseudo
     CDS             complement(86..235)
                     /locus_tag="VVO18_001223"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007895229.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
     gene            complement(389..2020)
                     /gene="rlmD"
                     /locus_tag="VVO18_001224"
     CDS             complement(389..2020)
                     /gene="rlmD"
                     /locus_tag="VVO18_001224"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000914584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEU5586386.1"
                     /translation="MLKKNDIVEVEIVDLTHEGAGVAKVDGLVFFVENALPSEKILMR
                     VLKVNKKIGFGKVEKYLVQSPHRNQDLDLAYLRSGIADLGHLSYPEQLKFKTKQVKDS
                     LYKIAGIADVEVAETLDMEHPVKYRNKAQVPVRRVNGVLETGFFRKNSHNLMPLEDFF
                     IQDPVIDQVVVALRDLLRRFDLKPYDEKEQSGLIRNLVVRRGHYSGQIMVVLVTTRPK
                     VFRVDQLIEQVIKQFPEIVSVMQNINDQNTNAIFGKEWRTLYGQDYITDQMLGNDFQI
                     AGPAFYQVNTEMAEKLYQTAIDFAELKKDDVIIDAYSGIGTIGLSVAKHVKEVYGVEL
                     IPEAVENSKKNAQLNNISNAHYVCDTAENAMKNWLKDGIQPTVILVDPPRKGLTESFI
                     KASAQTGADRIAYISCNVATMARDIKLYQELGYELKKVQPVDLFPQTHHVETVALLSK
                     LDVDKHISVEIELDEMNLTSAESKATYAQIKEYVWNKFELKVSTLYIAQIKKKCGIEL
                     REHYNKSKKDKQIIPQCTPEKEEAIMDALRHFKMI"
     gene            complement(2094..3068)
                     /locus_tag="VVO18_001225"
     CDS             complement(2094..3068)
                     /locus_tag="VVO18_001225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1002 domain-containing protein"
                     /protein_id="HEU5586387.1"
                     /translation="MRKKLFLTSAAVLWAVTAMNSVHAATDVQKVIDETYVQPEYVLG
                     SSLSEDQKNQTLKKLGYNASTDTKELKTMTPDVYSKIMNVANDSSLQLYSSAKIQKLG
                     DKSPLEVKIETPENITKVTQDMYRNAAVTLGMEHAKITVAAPIPVTGESALAGIYYSL
                     EANGAKVPQANKDLAQEELKALSDINAENKDKSGYDANKLNVALADIKSGLAKAKESK
                     GNLTEEDIRKIVEDTLKNYKLDQVITGNQINIIINFALNLSKSDILSNADFTKTLNDL
                     KQSIVSQAGDSFKNINLNFDADKALEDGGNFLSSLWQALVNFFKSFGS"
     gene            complement(3142..3756)
                     /gene="pmp23"
                     /locus_tag="VVO18_001226"
     CDS             complement(3142..3756)
                     /gene="pmp23"
                     /locus_tag="VVO18_001226"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000476388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall hydrolase Pmp23"
                     /protein_id="HEU5586388.1"
                     /translation="MFKRIRRVLVLAVFLFAGYKAYRVHQDVKQVMTYQPMVREILSE
                     KDTPANEELVLAMIYTETKGKEGDVMQSSESASGSTNTINDNASSIRQGIQTLTGNLY
                     LAQKKGVDIWTAVQAYNFGPAYIDFIAQNGKENTLALAKQYSRETVAPLLGNTTGKTY
                     SYIHPISIFHGAELYVNGGNYYYSRQVRLNLYIIKCFTLFSTSG"
     gene            complement(3756..4730)
                     /locus_tag="VVO18_001227"
     CDS             complement(3756..4730)
                     /locus_tag="VVO18_001227"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid-associated protein"
                     /protein_id="HEU5586389.1"
                     /translation="MDIYIKKAIIHQFSPDDTELFLADKFLNITPKIEEYLRKKIEHV
                     YSDEAKTGIFEEENPFFNHITDDLLETSVTLANLWKEEFSISENLKTNDLIFVQFSKE
                     GVEHFAFLRIALRETLTHLGGEVDNPIKLTQNNLPGFGTGADEALVVNLQSSKYHLIE
                     KRIKYNGTFLNYFSDNLLAVAPKISPKKSIKELEKTAQRIAESFNTDDFQFQSKVKSA
                     IFNNLEESNELSPEKLANDLFDNNLTARLSFIDQVKEAVPEPVQFDEIDASRQLKKFE
                     NQKLSLSNGIELIVPNNVYQDAESVEFIQNENGTYSILIKNIEDIQSK"
     gene            complement(4738..5994)
                     /locus_tag="VVO18_001228"
     CDS             complement(4738..5994)
                     /locus_tag="VVO18_001228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863152.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine hydroxymethyltransferase"
                     /protein_id="HEU5586390.1"
                     /translation="MIFDKDDFKAYDADLWNAIAKEEERQQNNIELIASENVVSKAVM
                     AAQGSILTNKYAEGYPGRRYYGGTDVVDVVETLAIERAKEIFGAKFANVQPHSGSQAN
                     CAAYMSLIEPGDTVMGMDLASGGHLTHGAPVSFSGQTYNFVSYSVDPETELLDFDAIL
                     KQAQEVKPKLIVAGASAYSQIIDFSKFREIADAVGAKLMVDMAHIAGLVAAGLHPSPV
                     PYAHITTTTTHKTLRGPRGGLILTNDEELAKKINSAIFPGIQGGPLEHVVAAKAVSFK
                     EVLDPAFKEYAANVIKNSKAMADVFLQDPDFRIISGGTENHLFLVDVTKVVENGKVAQ
                     NLLDEVNITLNKNSIPYETLSPFKTSGIRIGAAAITARGFGEEESRKVAELIIKTLKN
                     SENEAVLEEVRSAVKELTDAFPLYED"
     gene            complement(6056..6487)
                     /locus_tag="VVO18_001229"
     CDS             complement(6056..6487)
                     /locus_tag="VVO18_001229"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000942930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586391.1"
                     /translation="MLRDLQETDVKAICDINQEALGYTFSPEETASQLARLSQDSHHF
                     LLGYEDAANHVLLGYVHAEVYESLYSKAGFNILALAVSPQAQGQGIGKSLLQGLEEEA
                     KRCGYGFIRLNSANHRLGAHAFYEKVGYTCDKMQKRFIRIF"
     gene            complement(6489..7091)
                     /locus_tag="VVO18_001230"
     CDS             complement(6489..7091)
                     /locus_tag="VVO18_001230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000969297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonylcarbamoyl-AMP synthase"
                     /protein_id="HEU5586392.1"
                     /translation="MMDRIRQELENGGAVVLPTETVYGLFAKALDEKAVDHVYQLKRR
                     PRDKALNLNIASFEDILHFSKNQPTYLQKLVETFLPGPLTIILEANDRVPYWVNSDLA
                     TIGFRMPSHPITLDLIRETGPLIGPSANISGQASGVTFEQILKDFDQEVLGLEDDAFL
                     TGQDSTIVDLSGDKVKILRQGAIKREDILARLPEISFEEA"
     gene            complement(7075..7914)
                     /gene="prmC"
                     /locus_tag="VVO18_001231"
     CDS             complement(7075..7914)
                     /gene="prmC"
                     /locus_tag="VVO18_001231"
                     /EC_number="2.1.1.297"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor N(5)-glutamine
                     methyltransferase"
                     /protein_id="HEU5586393.1"
                     /translation="MKLAQLFSNFEEELIRQGEEAESLSFVYRSLKNLSFTDFIFALQ
                     QEVTTEEEKQFVEDIYQQLAAHKPAQYIIGQADFYGMHLKVDERVLIPRPETEELVEL
                     ILTENLETNLSVLDIGTGSGAIALALAKNRPDWSVTAADVSQEALELASENASDQNLN
                     IFFKKSDCFAEISEKYDIIVSNPPYISREDESEVGLNVLHSEPHLALFADEDGLAIYC
                     RIAEDAKDYLKDGGKIYLEIGYKQGQSVPELFRKHLPEKKVRTLKDQFGQNRMVVVDD
                     GQD"
     gene            complement(7914..8993)
                     /gene="prfA"
                     /locus_tag="VVO18_001232"
     CDS             complement(7914..8993)
                     /gene="prfA"
                     /locus_tag="VVO18_001232"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide chain release factor 1"
                     /protein_id="HEU5586394.1"
                     /translation="MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSKEEASNR
                     DTVIAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILL
                     LPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGG
                     FKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMLEVEEVEYDI
                     DPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIR
                     ARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTIL
                     SGKLDEVVDALVLYDQTQKLEELNK"
     gene            complement(8990..9580)
                     /locus_tag="VVO18_001233"
     CDS             complement(8990..9580)
                     /locus_tag="VVO18_001233"
                     /EC_number="2.7.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000068157.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thymidine kinase"
                     /protein_id="HEU5586395.1"
                     /translation="MAQLYYRYGTMNSGKTIEILKVAYNYEEQGKGVVIMTSALDTRD
                     GVGYVSSRIGMKRPALAIEETTDIFGYIRDLPEKPYCVLVDEAQFLKRHHVYDLARVV
                     DELDIPVMAFGLKNDFRNELFEGSKYLLLLADKIDEIKTICQYCKKKATMVLRTQDGL
                     PVYDGEQIQIGGNETYISVCRKHYFAPEINKENEEK"
     gene            9704..9886
                     /locus_tag="VVO18_001234"
     CDS             9704..9886
                     /locus_tag="VVO18_001234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005589823.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-oxalocrotonate tautomerase"
                     /protein_id="HEU5586396.1"
                     /translation="MPFVRIDLFEGRTLEQKKALAKEVTEAVVRNTGAPQSAVHVIIN
                     DMPEGTYFPQGEMRTK"
     gene            10022..11395
                     /gene="mnmE"
                     /locus_tag="VVO18_001235"
     CDS             10022..11395
                     /gene="mnmE"
                     /locus_tag="VVO18_001235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002906470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="HEU5586397.1"
                     /translation="MITREFDTIAAISTPLGEGAIGIVRLSGTDSFAIAQKIFKGKDL
                     NKVASHTLNYGHIIDPLTGKVMDEVMVGAMKSPKTFTREDIIEINTHGGIAVTNEILQ
                     LAIREGARLAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMNIAVKQLDGSLSD
                     LINNIRQEILNTLAQVEVNIDYPEYDDVEEATTAVVREKTMEFEQLLTKLLRTARRGK
                     ILREGISTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNINGVPLKLI
                     DTAGIRETDDIVEQIGVERSKKALKEADLVLLVLNASEPLTAQDRQLLEISQDTNRII
                     LLNKTDLPETIETSKLPEDVIRISVLKNQNIDKIEERINNLFFENAGLVEQDATYLSN
                     ARHISLIEKAVESLQAVNQGLELGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLF
                     SQFCLGK"
     gene            complement(11442..12377)
                     /gene="dapA"
                     /locus_tag="VVO18_001236"
     CDS             complement(11442..12377)
                     /gene="dapA"
                     /locus_tag="VVO18_001236"
                     /EC_number="4.3.3.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002935444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="HEU5586398.1"
                     /translation="MSYQDLKECKIITAFITPFHEDGSINFDAIPALIEHLLAHHTDG
                     ILLAGTTAESPTLTHDEELELFAAVQKVVNGRVPLIAGVGTNDTRDSIEFVKEVAEFG
                     GFAAGLAIVPYYNKPSQEGMYQHFKAIADASDLPIIIYNIPGRVVVELTPETMLRLAD
                     YPNIIGVKECTSLANMAYLIEHKPEEFLIYTGEDGDAFHAMNLGADGVISVASHTNGD
                     EMHEMFTAIAESDMKKAAAIQRKFIPKVNALFSYPSPAPVKAVLNYMGFEAGPTRLPL
                     IPAPEEDAKRIIKVVVDGDYEATKATVTGVLRPDY"
     gene            complement(12433..13509)
                     /locus_tag="VVO18_001237"
     CDS             complement(12433..13509)
                     /locus_tag="VVO18_001237"
                     /EC_number="1.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000542485.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate-semialdehyde dehydrogenase"
                     /protein_id="HEU5586399.1"
                     /translation="MGYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKS
                     LKFKDQDITIEETTETAFEGVDIALFSAGGSTSAKYAPYAVKAGVVVVDNTSYFRQNP
                     DVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGA
                     GMGAILETQRELREVLNDGVKPRDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYT
                     YEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAF
                     PGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNS
                     VQIAETLHERGLVRPTAELKFELK"
     gene            complement(13852..13924)
                     /locus_tag="VVO18_001238"
     tRNA            complement(13852..13924)
                     /locus_tag="VVO18_001238"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(13889..13891),aa:Thr,seq:ggt)
     gene            complement(14024..14533)
                     /locus_tag="VVO18_001239"
     CDS             complement(14024..14533)
                     /locus_tag="VVO18_001239"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262434.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="QueT transporter family protein"
                     /protein_id="HEU5586400.1"
                     /translation="MKKLTIRDVADIAIVAAIYVVLTVTPPLNAISYGAYQFRISEMM
                     NFMAFYNPKYIIGVTIGCMIANFFSFGLLDVFVGGGSTLVFLSLGVWLFAKYSKDYLF
                     NGLIRKDHFFFSILFSISMFTIAAELNIVAELPFFLTWFTTGIGEFASLIIGAIIIGK
                     IGRRIDLSK"
     regulatory      complement(14531..14627)
                     /regulatory_class="riboswitch"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
     gene            14656..15087
                     /locus_tag="VVO18_001240"
     CDS             14656..15087
                     /locus_tag="VVO18_001240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GtrA family protein"
                     /protein_id="HEU5586401.1"
                     /translation="MKKPIQKFFNNEILAYLFFGLATTLVSILSRLVIYQLSHQELLA
                     TALANIIGILFAFITNDTIVFKQKKKNRLIRLVKFSLARLSTFLLDLFLTFLFVTQFP
                     HIIGQFVTENIDKINAIETIIAQIFIIIINYILSKVYIFRK"
     gene            15169..15546
                     /gene="mscL"
                     /locus_tag="VVO18_001241"
     CDS             15169..15546
                     /gene="mscL"
                     /locus_tag="VVO18_001241"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="large conductance mechanosensitive channel
                     protein MscL"
                     /protein_id="HEU5586402.1"
                     /translation="MLKNLKSFLLRGNVIDLAVGVVIASAFGAIVTSLVNDIITPLIL
                     NPALKTAKVERIAQLSWHGVGYGNFLSAIINFIFVGTALFFIIKGIEKAQKLTGIKEE
                     KTAEKKPTELEVLQEIKALLEKK"
     gene            complement(15588..16682)
                     /gene="hemH"
                     /locus_tag="VVO18_001242"
     CDS             complement(15588..16682)
                     /gene="hemH"
                     /locus_tag="VVO18_001242"
                     /EC_number="4.98.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ferrochelatase"
                     /protein_id="HEU5586403.1"
                     /translation="MKKAILMMTFGSPEEISFEGVAEFFTNIRRGVRPQDHEIQTLYD
                     NYIRIGGTPLQRITREEVNLVKERLGEEYGIYFANKFSRPFIPDVIKQMETDGVEECI
                     CLILEPHYSFYSVMGYEKFLESQQIRFLVIKDWYQQQSLLDFWTDEIRKILRNEVGEE
                     SFKVIFSAHSVPIFALDYGDPYIDQIFDNSRLIAEQLGLMTDQYTNTWQSESDIGIPW
                     IKPDVLEYLREQKQHPEHYIFVPISFISEHIEVLFDNDVECYDLCQELGVTYHRPPMP
                     NTDSRLIDALVATVRANEDKEFKTFLPEEETFDELAPSATTKDIMKETDDLQMPEFVK
                     KLIEKKGRENVKMPYLIKKMLEKAGKLPKE"
     gene            complement(16760..17546)
                     /gene="srtB"
                     /locus_tag="VVO18_001243"
                     /pseudo
     CDS             complement(16760..17546)
                     /gene="srtB"
                     /locus_tag="VVO18_001243"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000856390.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="class B sortase"
     gene            complement(17661..18659)
                     /gene="srtG1"
                     /locus_tag="VVO18_001244"
     CDS             complement(17661..18659)
                     /gene="srtG1"
                     /locus_tag="VVO18_001244"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000851047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-2 pilus system class B sortase SrtG1"
                     /protein_id="HEU5586404.1"
                     /translation="MKTKREKPKKSLSRRLVLAVDGVINHLLLIFAALIFLFGFYALW
                     DSNQVYSLASSSEYEAYRPVTTQQDELASFSGFSKLQELNPEVLGWINVYGTNIDYPL
                     VQAKDNEKYLNKDSKGEFAATGAIFLDARNNPKFEDFNTIIYGHHVENGVMFGDVAKF
                     ADQEFFDQHRYGSIYYNGVEKGLEIFEMLEVDAYDFNIYDPGIQGEDRQQAYLDHLLS
                     VAMHKRDISLSPSDRIILLSTCFLDVTNGRHIVVAKITDTVPKNTFHTKKSKPFPYSV
                     FDDSSLGRFLSSIPLWIWYLILFVLFLLLIFLLLVLYLILRRRRESKKNARSRPFY"
     gene            complement(18677..19873)
                     /gene="pitB"
                     /locus_tag="VVO18_001245"
     CDS             complement(18677..19873)
                     /gene="pitB"
                     /locus_tag="VVO18_001245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750612.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-2 pilus major pilin PitB"
                     /protein_id="HEU5586405.1"
                     /translation="MKKTFFKKLFTASIAAITALSVFRGVPTFADDNSAITKANGENN
                     AVVKINKTLNIAEGITTPTATFTFKFTEKTGQSSNGAPYQTGVAIPDRNVEYNKNDHP
                     TADKIQKATEDIFSGVAYGHAGEYVYDVAEAKTGWQAITKNGKTIDAMRYDKRTYEMH
                     VIVKNKVNGGVYISSVYFKENNKSNAPKVEPSEQGVYNLFDNTYTKDASKEPNPDDPS
                     QVDPNAKALTITKKVDGASGDKTRDFQFHIKIQLPSTNKTAETPVTNIIVKHGSKSEV
                     LAVVTPADTVEYNFTLKDGETFTVEQLPAGSKYTVTETGVAGYTDSSIYTTNGAEQTS
                     QGQKNVDFTLTDILIGEKKNDNKVTNKIDDVTPTGLLIDNLPFILMIGLGLAGFVVLS
                     KKRREA"
     gene            complement(19918..20469)
                     /gene="sipA"
                     /locus_tag="VVO18_001246"
     CDS             complement(19918..20469)
                     /gene="sipA"
                     /locus_tag="VVO18_001246"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-2 pilus system signal peptidase SipA"
                     /protein_id="HEU5586406.1"
                     /translation="MLLKKKHKKPVTQVNRDKSPPSVWGDILYLVSKLLMVGFVLATL
                     YFFVFGLLRYNDDGMKPALKDGDLVVYYRLDKRYSIGDLLVYSYKGKERVARVIATEG
                     STIDINENGLIINGSPQQEQDIYKETLLYKEGATFSMKVPAGQLFVLGDNRTTAVDSR
                     AFGTIPIQDTQGKVVTVIRRRGF"
     gene            complement(20469..23054)
                     /gene="pitA"
                     /locus_tag="VVO18_001247"
                     /pseudo
     CDS             complement(20469..23054)
                     /gene="pitA"
                     /locus_tag="VVO18_001247"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516426.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PI-2 pilus tip adhesin PitA"
BASE COUNT         6580 a         4870 c         4382 g         7248 t
ORIGIN      
        1 tttgagtttt aaactttggt agaagtcttg aactccttat atttacataa ctatttgcct
       61 ctataactat tatgacacga aaccaacaag caagttcaag cacctccata tctttattca
      121 aatgaggact aagatattca caaactttat cataaacctc tttatctttt ttcataaaag
      181 gggcatacaa cttagcaaat ttatcctaaa attttttgtt gcctttatca atcatttcaa
      241 cactccttta aatataaaaa tgatcctatc aatctttata ttgagcctat tttctaattg
      301 ataccttgca agaaaggaat aatagctgtt cctataccaa gtaggaatgt aataaatgca
      361 gaaagtcata tactgtcatt cttttctatt aaatcatttt gaagtgtctc aaagcatcca
      421 tgatggcttc ttctttttca ggtgtacact gtggaataat ttgtttatcc tttttagact
      481 tgttgtaatg ttctcgtaat tctattccac atttcttttt tatctgtgca atatataatg
      541 tcgaaacttt taattcaaat ttattccaaa catattcttt gatttgagca tatgttgctt
      601 tgctctccgc acttgtcaaa ttcatctcat ccagctcaat ttcaacactt atgtgcttat
      661 cgacatcgag tttggacaaa agtgctaccg tctcgacgtg atgcgtttga ggaaatagat
      721 ccaccggctg gactttcttc aattcatatc ccaattcttg gtagagtttg atatcacgcg
      781 ccatggttgc gacattgcag gagatatagg cgatgcgatc ggctcctgtt tgggcgcttg
      841 ctttgataaa gctttctgtc aagcccttgc gtggaggatc aaccaagata acggttggtt
      901 gaatcccatc tttaagccaa ttcttcatag cattttcagc tgtgtcacag acatagtggg
      961 cgtttgaaat attgttcagc tgagcatttt ttttactatt ctctactgct tctggaatca
     1021 gttcaacacc gtagacttct ttgacatgct tggcgactga taaaccaatg gttccaatac
     1081 cagaataggc atcaataatc acatcatctt tttttaactc tgcaaagtca atggctgttt
     1141 gatagagttt ctccgccatt tcagtattga cttggtaaaa ggctgggcca gcgatttgga
     1201 agtcatttcc caacatctgg tccgtaatat agtcttgacc ataaagagtg cgccactcct
     1261 taccaaaaat cgcattggta ttctggtcgt tgatattttg catgacagac acaatctctg
     1321 ggaactgctt gataacttgt tcaatcaatt ggtcaacacg aaaaactttt ggacgagttg
     1381 tcaccaaaac gaccatgatt tgtcctgaat agtgaccacg acgcaccaca agattccgaa
     1441 tcaatccaga ttgttccttt tcgtcataag gttttaaatc aaaacgacgg agcaggtctc
     1501 gaagagctac tacgacttgg tcaatgacag gatcctggat aaagaaatct tcaaggggca
     1561 tgaggttatg cgaattctta cggaaaaatc ctgtttccaa gacaccattc actcgacgaa
     1621 cgggcacctg cgccttattg cgatacttga ctggatgttc catatcaagc gtttcagcaa
     1681 cttctacatc tgcaattcca gcaatcttgt agagactgtc cttgacttgc ttggttttaa
     1741 acttgagctg ttctggataa gaaaggtgtc ctaaatccgc gattcctgaa cgcaggtaag
     1801 ccaaatctag atcttgatta cggtgtggtg actggacaag gtatttttca acttttccaa
     1861 agccaatctt tttattgacc ttgaggacac gcatgagaat tttttcactc ggtaaagcat
     1921 tctctacaaa aaagaccaaa ccatctacct tggcaactcc tgccccttca tgggtcaaat
     1981 caacaatttc aacttctaca atatcatttt tctttaacat tcttttctct ttctattggc
     2041 cgacaaaaaa gacggcaacg ttacggttac catccattat accatgaaat ttcttaagaa
     2101 ccaaaactct tgaagaagtt gacaagggct tgccagaggg agcttaagaa gttaccaccg
     2161 tcctctagcg ccttatccgc atcaaagtta aggttgatat ttttaaaact gtcgccagct
     2221 tgtgatacga tgctttgttt aaggtcattt agggttttag tgaaatctgc attgctgagg
     2281 atatcactct ttgagagatt caaggcaaaa ttgatgatga tattgatctg gtttcctgtt
     2341 atgacctgat caagtttgta attttttaag gtatcttcaa caatcttgcg gatatcttct
     2401 tctgtcagat ttcccttgct ttctttagct ttggcgagtc ctgacttgat atcagctagg
     2461 gcaacgttta atttattagc atcatagcct gatttgtcct tgttttcagc attgatatct
     2521 gacaaagctt ttagctcttc ttgagccaaa tctttattag cttgtggcac cttggctcca
     2581 ttagcctcta gcgaatagta aatccctgct aaagcacttt ctcctgtaac tggaataggg
     2641 gctgctacag tgattttggc atgttccata cccagcgtta ctgctgcgtt tcggtacata
     2701 tcctgagtca ccttagtgat attttctggt gtttcaatct tgacctcaag tggcgatttg
     2761 tcacctagct tttgaatctt ggctgatgaa tacaactgta agctagagtc attggccaca
     2821 ttcatgattt tagaataaac atcaggtgtc atggtcttga gttctttggt atctgttgag
     2881 gcattgtagc ccagtttttt aagagtttga tttttttggt cttcagatag ggaggaacct
     2941 aggacatatt caggttggac ataggtttca tcgataactt tttgaacatc tgttgctgca
     3001 tggacgctat tcatagctgt tactgcccac aagaccgcag cactagtcag aaagagtttc
     3061 tttctcatag ggaatttcct cctttacttc tttatagtaa tatatctatc ttaaagaaaa
     3121 cttataacaa aaacacctgg tctagccaga tgttgaaaag agagtgaaac atttgatgat
     3181 gtaaaggtta agtcgtacct gtctagaata ataatagttt cctccattta catagagttc
     3241 agcaccgtga aaaatggaaa tggggtgaat ataactataa gtctttccag tcgtattacc
     3301 aagcaagggg gcaacagtct cacgagagta ctgtttggct agagccaagg tattttcctt
     3361 gccattttgg gcgataaaat cgatataggc aggtccaaaa ttataggctt gaacagctgt
     3421 ccagatatct acacccttct tctgcgccag atagagattg cctgtcagag tttgaatgcc
     3481 ttgccgaatg ctagaggcat tatcattgat ggtgttggtg gaaccacttg cagactcact
     3541 agactgcata acatcgcctt cttttccttt tgtttcagta taaatcatag caagcacaag
     3601 ctcttcgttt gctggggtgt ctttttcact caatatttct cgcaccatgg gttgataggt
     3661 catgacttgt ttgacatctt gatgaacgcg gtaagcttta tagccagcaa aaaggaagac
     3721 tgctagtaca agcactcttc gaattcgttt aaacattatt tactttggat atcctcgata
     3781 tttttgatta agatagagta ggttccattt tcgttttgga taaactcaac agactcggcg
     3841 tcttgataga cgttattggg aacgatgagc tcaattccat ttgataagga gagtttttgg
     3901 ttttcaaatt tctttaattg gcgactggca tcaatttcat caaattgaac aggttctggt
     3961 acggcttctt tgacttggtc aataaagctc aaacgagccg tcagattgtt gtcaaaaagg
     4021 tcattagcca atttctcagg tgacaattca ttgctttctt ctaggttgtt gaaaatagct
     4081 gatttgacct tggattgaaa ttgaaaatca tctgtgttaa aagattcagc aattctctgg
     4141 gctgtttttt ccagttcctt gatagatttt ttaggagaaa tcttaggagc gacagcaaga
     4201 agattatctg aaaaatagtt caaaaaagtc ccgttgtact tgattcgttt ttcaatcagg
     4261 tgatacttgc tactctgaag attgaccacc aaggcctcat cagctcctgt tccaaatcca
     4321 ggcaggttat tctgagttag cttgattgga ttatcaactt ctcctccgag gtgggtcaag
     4381 gtctcccgca gggcaattcg caagaaagcg aaatgttcta caccttcttt agaaaattga
     4441 acaaaaatca agtcattggt cttgagattt tcagaaatgc taaactcctc tttccagaga
     4501 ttagccagcg ttactgatgt ctccaacaaa tcgtctgtaa tatgattgaa gaagggattt
     4561 tcttcttcga aaatcccagt cttggcttca tctgaataca catgttcaat ttttttacgt
     4621 aggtattctt cgatttttgg agtaatattg agaaacttat ctgctaagaa cagctcggta
     4681 tcatccggac tgaactggtg aataatggct ttcttaatat aaatatccat aaaagtttta
     4741 gtcctcgtat aatgggaagg catctgtcaa ttctttgact gcacttctca cttcttctaa
     4801 tacagcctca ttttctgaat tcttaagggt tttaatgatg agttcagcca ctttgcgact
     4861 ttcttcttca ccaaatccac gtgcagtaat agctgctgct ccgatacgaa tcccacttgt
     4921 cttgaatggc gacaaggttt cgtaagggat tgaattttta tttagggtaa tattgacttc
     4981 atccagcaag ttttgagcaa cttttccgtt ttctacaacc ttagtcacat caacaaggaa
     5041 gagatggttt tcagttccac ctgaaataat acggaaatca gggtcttgca agaagacatc
     5101 tgccatagcc ttgctgttct taattacatt ggcagcatat tccttgaagg ctggatccaa
     5161 aacttctttg aaggaaactg ccttagccgc cacaacatgc tctaaaggac cgccctgaat
     5221 acctgggaaa atagctgaat tgattttttt agcaagttct tcgtcattgg tcaaaatcaa
     5281 accaccacga ggtccacgaa gggttttgtg ggtcgttgtt gttgtgatat gagcgtatgg
     5341 aactgggctt ggatgaaggc cagccgcaac caaaccagcg atatgggcca tgtccaccat
     5401 gagcttcgca ccgacagcat ctgcgatttc acggaatttt gaaaaatcga taatttgaga
     5461 atatgctgaa gcaccagcta caatcagttt tggttttact tcttgggctt gtttcaagat
     5521 agcatcaaag tctaagagtt ccgtttcagg atcaacacta taagaaacaa agttgtaggt
     5581 ttgaccagag aagctaacag gagccccatg agtcaaatga ccacctgatg ccaaatccat
     5641 tcccataacc gtatcacctg gctcaatcaa ggacatgtaa gccgcacagt tagcttggct
     5701 tcctgaatgt ggttggacat tggcaaattt agcaccgaaa atttcttttg cgcgttcaat
     5761 agcaagagtc tctacaacgt ctactacatc agttccacca taataacggc gtcctgggta
     5821 accctcggca tatttatttg tcaagataga cccttgagct gccataacag ccttggaaac
     5881 tacgttttcc gaagcaatta actcgatatt attttgttgg cgttcttctt ctttggcaat
     5941 agcattccag agatcagcat catatgcttt aaaatcatct ttgtcaaaaa tcataggtct
     6001 tctcctttat tgtgtgacta gtccattagt ttgattttac aataagaaaa tcaaactaaa
     6061 agatgcgaat aaaccgtttc tgcattttat cacaagtata gccaactttt tcataaaatg
     6121 catgagcacc cagacgatga ttggcagaat ttaagcggat aaacccataa ccacatcttt
     6181 ttgcttcttc ttccaaccct tgtagtaaac ttttaccaat accttgacct tgcgcttgag
     6241 gtgaaactgc taaagctaag atattaaatc ctgctttgga atagagtgat tcgtaaactt
     6301 cagcgtggac atatccaagt aagacatgat tagctgcatc ctcatagcca agtaggaaat
     6361 gatgggaatc ctgagacagt ctagctagtt ggctagccgt ttcctctgga ctaaaagtat
     6421 aacccaaagc ctcttggttg atgtcacata tcgctttcac atctgtttct tgcaaatctc
     6481 ttagcatttc aagcctcctc aaaagaaatc tctggcaacc gagcaagaat atcttctcgt
     6541 ttaattgcgc cttggcgtaa gattttcacc ttgtctccag acaaatccac aatagttgaa
     6601 tcctgtccag ttagaaaagc atcgtcttcc agacccagaa cctcttggtc aaaatccttc
     6661 agaatttgtt caaaggttac accacttgcc tgacctgaga tattggcaga cggcccaatc
     6721 aagggacctg tctctcgaat taaatccagt gtgatagggt gactgggcat ccgaaatcca
     6781 atagttgcaa ggtcagaatt tacccaatag ggaactcggt cattggcttc gagaataatg
     6841 gtcaagggac ctggcaaaaa ggtctctaca agtttttgta gataagttgg ctgattctta
     6901 gaaaagtgca agatatcctc gaaagaggcg atattgagat tgagtgcctt atctctagga
     6961 cgacgtttga gttggtaaac atggtcaact gctttttcat ctaaggcctt ggcaaaaaga
     7021 ccataaacag tctctgtagg tagaacgaca gctccaccat tttccaactc ttgtctaatc
     7081 ctgtccatca tcaaccacaa ccatcctatt ttgaccaaat tggtctttga gtgttcgaac
     7141 ttttttttca ggaagatgtt ttctaaaaag ttcgggaaca ctttgacctt gcttgtatcc
     7201 aatttcaagg taaatcttac caccatcctt gagatagtct tttgcatctt ccgcaattct
     7261 acagtaaata gctaggccat cctcgtctgc aaagagagct agatgaggct ccgaatgcaa
     7321 aacattcaag cctacctctg actcatcttc acgagagata tagggtggat tggatacaat
     7381 tatatcatat ttttcagaaa tttctgcaaa acaatcagat tttttaaaaa atatattaag
     7441 attttgatcg ctagcattct ctgatgcaag ctctaaggcc tcttgagaaa catctgctgc
     7501 tgtcactgac caatctggtc tattttttgc tagagcgaga gcaatagctc cactacctgt
     7561 tccaatatcc agaactgaga gattcgtctc aagattttca gttagaataa gctccactaa
     7621 ctcctctgtt tctggacgag gaatcaaaac ccgttcatcc acctttaaat gcattccata
     7681 aaaatctgcc tgtccaatga tgtactgagc tggcttgtga gctgctagtt gctggtaaat
     7741 atcttctaca aattgttttt cttcctctgt tgtcacctcc tgctggaggg caaaaataaa
     7801 gtctgtaaaa gatagatttt tcagactacg atagacaaaa gagaggcttt ccgcttcctc
     7861 tccttgtctt atcaactctt cttcaaaatt tgaaaataat tgagctaatt tcattatttg
     7921 tttaattctt ctagtttttg tgtttggtca taaagcacca aggcatccac aacttcgtcc
     7981 aatttaccag acaaaatcgt atctagtttt tggagggtca agccgatacg gtggtctgtg
     8041 acacggtttt gtgggaagtt ataagttcgg atccgttctg aacggtcacc agtaccgatt
     8101 gtcgacttac gctcagcgtc ttgttcatcc tgagcaatct gagcaaagtg gtcagcgacg
     8161 cgtgcacgga taatcttcat agccttctcg cggttcttct gctgggtacg ttcttcctgc
     8221 atctcaacct tgatattggt tggcaagtga acgatacgaa cggcagtcgc aaccttattg
     8281 acgttctgtc caccagcacc agaggcgtga tagatgtcga cacgaaggtc ttttggatca
     8341 atgtcgtatt caacctcttc aacttctagc ataacaagaa ctgtcgctgt cgaagtatga
     8401 acacggcctt ggctttctgt cacaggaaca cgttgcacac ggtgggcacc tgattcatac
     8461 ttaagcttag agtatacaga ctgacctgaa accatagcaa ccacttcttt aaaaccaccg
     8521 acaccattca tagaggcttc catgacttca aagcgccaac cttgggcttc cgcatacttt
     8581 tggtacatag ttagcaaatc tccagcgaaa agtgccgctt cgtctccacc agctgctcca
     8641 cggatttcaa ggatgatatt cttgtcatcg tttggatcct ttggaaggag caaaattttc
     8701 agtttttctt catattcttc tttttcagcc ttggcatctt tgagttcttg cttggccatt
     8761 tcttccaagt ccgcatctcc gcctgattcc ttaatcatct cttcggcatc gacgatattt
     8821 tgaaggactt gtttatactc acggtaggct attacggtgt cacgattgga agcttcttct
     8881 tttgaaagct ccataaaacg cttggtgtct gaaacgacat cagggtcact cagcaattct
     8941 cctagttctt cataacggtc ttctacagct tgtagttgat catagatgtt catttttctt
     9001 cattctcctt attgatttca ggggcaaaat aatgtttacg gcaaaccgag atataggttt
     9061 cattaccacc aatctggatc tgttctccat cgtaaacggg cagtccatcc tgtgttcgca
     9121 acaccatggt cgcctttttc ttgcaatact gacatatggt cttgatttcg tcaatcttgt
     9181 ctgctaaaag caagagatat ttggaacctt cgaacaattc attgcgaaag tcatttttca
     9241 agccaaaagc catgacgggt atgtctaact cgtccacaac acgagctagg tcgtaaacat
     9301 ggtggcgttt gagaaactgg gcttcatcga ccaaaacaca gtaaggtttt tctggtaggt
     9361 ctcggatata gccaaagata tccgttgttt cctcaatcgc aagggcaggg cgtttcatgc
     9421 caattcgact cgacacatag ccaacaccgt cacgcgtatc cagagccgaa gtcataatga
     9481 caacaccttt tccttgctcc tcgtagttat aggccacttt gagaatctca atcgttttac
     9541 cagagttcat ggtcccataa cgataataca actgtgccat gtttcttgct tcacgtccat
     9601 ttctaaattt ttgctacatt ctagtatatc ataattttct taagctttaa acggcaaaat
     9661 gtggtaaaat agaagaaatc aaaaactagt ggaggaagct attatgccat ttgtacgcat
     9721 cgatttattt gaaggacgca cgctcgagca aaagaaagct cttgctaagg aagtaacgga
     9781 agcggttgtt cgcaacactg gagcccctca atctgctgtt catgtcatca tcaacgacat
     9841 gccagaagga acttatttcc cacaggggga aatgcgcacc aaataagcta gcttaagcag
     9901 aattgcttag gctttttcaa tctccaagta gcacccattg aagaaatagt ctaaatttgt
     9961 tacaatttga aaagagactt ggaaaattcc aagaaaagag caattaatta aaggaaatat
    10021 tatgattaca cgtgaatttg ataccatcgc tgctatctct actccactag gtgaaggagc
    10081 tattggtatt gtccgcctga gcggaacaga cagttttgct attgcgcaaa agatttttaa
    10141 aggaaaagac ttgaacaagg ttgccagcca cactctcaac tacggtcaca ttattgatcc
    10201 tctgactggt aaagtcatgg acgaggttat ggttggggct atgaagtctc caaagacctt
    10261 cactcgtgag gatattatcg agattaacac ccacggtggt attgcggtga ccaatgagat
    10321 tctccagcta gctatccgtg aaggagctcg gttggcagaa cctggtgaat ttaccaaacg
    10381 tgccttttta aacggtcgcg tagatttgac acaggccgag gcggtgatgg atatcatccg
    10441 agccaagaca gacaaggcca tgaacatcgc ggtcaaacaa cttgatggtt ccctttctga
    10501 tcttatcaat aatatccgtc aagaaatcct taacacactt gcccaagttg aggtcaatat
    10561 cgactatcct gagtatgacg atgttgagga agccactact gctgttgtcc gagagaagac
    10621 aatggagttt gagcaattac taaccaagct ccttaggaca gcacgtcgtg gtaaaatcct
    10681 tcgtgaagga atttcaacgg ctatcattgg acgtcccaac gttgggaaat caagccttct
    10741 caacaacctc ttgcgtgagg acaaggctat cgtaacagat atcgctggga caacacgaga
    10801 tgtcatcgaa gagtacgtca acatcaatgg tgtacctctc aaattgattg atacagccgg
    10861 tattcgtgaa acagatgaca tagtggaaca aatcggtgtt gagcgttcga aaaaagccct
    10921 caaggaagcc gacttggttc tactagtgct aaatgccagt gaaccactga ctgcgcaaga
    10981 cagacaactt cttgaaatta gccaagatac caatcgcatt attctactta ataaaaccga
    11041 cctgccagaa acgattgaaa cttcgaaact acctgaagac gttatccgta tttcagtcct
    11101 taaaaaccaa aacatcgata agattgaaga gcgaatcaac aacctcttct ttgaaaatgc
    11161 tggtttggtt gagcaagatg ctacctactt gtcaaacgcc cgtcacattt ccttgattga
    11221 gaaggccgtt gaaagcctac aagctgttaa ccaaggtctt gaactaggga tgccagttga
    11281 cttgcttcaa gttgacttga cccgtacttg ggaaattcta ggagaaatca ctggagatgc
    11341 tgctccagat gaactcatca cccaactctt tagccaattc tgtttaggaa aataagaaaa
    11401 atccatgatc cttcattcgg tcatggattt tattgtcttt attagtaatc tggtcttaag
    11461 acccctgtta cagttgcctt agttgcttcg tagtcgccat ctacgacaac cttgataatg
    11521 cgtttggcat cttcttctgg tgctggaata agaggtagac gagtgggtcc agcttcaaat
    11581 cccatatagt taagaactgc cttaactgga gcaggacttg gataagagaa gagagcatta
    11641 accttaggaa tgaatttacg ctgaattgct gcggctttct tcatatcgct ttctgcaatg
    11701 gcagtaaaca tctcgtgcat ttcatcccca tttgtatgag aggcaacaga aataacccca
    11761 tccgccccaa ggttcatggc atggaaagca tctccatcct cacctgtata aatcaagaac
    11821 tcttcaggct tgtgctcaat caagtaagcc atattagcca agctagtaca ttctttgaca
    11881 ccgataatat ttggatagtc agccaagcga agcatggttt ctggagtcaa ttcgacaact
    11941 acacgccctg gaatgttata gataataatt ggtaggtcag aagcatctgc aatagcctta
    12001 aagtgctgat acatcccttc ttgagaaggt ttgttgtagt aaggaacaat agcaagccca
    12061 gctgcgaaac caccaaattc cgctacttct ttgacaaact caatagagtc acgcgtatca
    12121 ttagtaccta cacccgcaat caaaggaacg cgtccattga caaccttttg tacagccgca
    12181 aacaactcca actcctcatc gtgggtcaaa gttggactct cagcagtcgt tcctgcgaga
    12241 agaattccat ccgtatgatg ggccaataaa tgctcaatca aggctggaat agcatcaaag
    12301 ttaatggaac catcctcatg gaagggggta ataaaggctg taatgatttt acattctttt
    12361 aaatcttgat aagacacgaa aacacctctc tatttcaaag aaggagttca tctgaactcc
    12421 taaacgatat gactatttta attcaaattt caattcggct gttggacgaa ccaatccacg
    12481 ttcatgaaga gtttcagcaa tctgaactga gttccaagca gcacctttga gaaggttatc
    12541 tgaaacaacc cacatgtgaa ttcctttttc tgcatccaag tctttacgga tacgaccaac
    12601 aaaggtatca cgcgaaccaa ctgcattgat ggcttgagga tagatttgat gagctacatc
    12661 atcttcaaga acagcacctg ggaaggctgc gatagctgct tttacttctt cgattggagc
    12721 cacttctttt gtttcgatat aaacagactc agagtgagct gacaagactg gaatacgcac
    12781 acatgttgca gatactgcaa tgctatcatc ttccataatt ttcttagttt ccttggtcat
    12841 cttcatctct tcgtaagtgt aatcattgtc agtgaagaca tcgatttgtg gaagagcatt
    12901 gaaggcgata ggataatgtt tcttgtcacc gcctgaaggt aagatttccg catgcaaatc
    12961 acgtggtttc actccatcat tcaagacctc acgaagttca cgttgtgtct caagaattgc
    13021 tcccatacca gcacctgaaa cggcttgata agttgaaaca atgatacggt ccaagcccca
    13081 tttttggcga accggctcaa gagccaccat catttggatt gttgaacagt tagggcaggc
    13141 aatgattccg ttgtgggcat caagtgcatg agcattgacc tctggaacaa ccaaaggaac
    13201 atctggattt tgacggaaat aagatgtatt atccactact accacgccag cttttactgc
    13261 gtatggtgca tacttagctg atgtcgaacc acctgctgaa aagagagcaa tatcaactcc
    13321 ttcaaaagct gtttcagtcg tttcttcaat cgtaatatct tgatctttaa atttcaatga
    13381 cttacctgct gaacgtgcag aagcaaggta acggatttta tcgattggaa gtgttgattc
    13441 ttccaacatt tttatcatct gagcaccgac agcacctgtc gcgccgacta cagcaactgt
    13501 atatcccata aataacctct ttcggaattt tctaaaaatt tctataatag aagtattata
    13561 ctactttttc catgaattgc aaagcttttt catcattttt tggaaaataa aaatccccaa
    13621 tcgctagact agggattaag aggcatcttc atgtgatgag caggttcaca caactcatca
    13681 aggtccgctc ctgcgttatg acctccttat gctcaatagt agtccgaaga ctacctatcg
    13741 actcatcgca tattctatat tactagagat acttgatttt gtcaataaga aattttttcg
    13801 atcgagtata acaaaaaact ctcgtattca agagtttccc tatacatatc atgctaattg
    13861 ccgggattga accggcgacc tcatccttac catggatgcg ctctgccaac tgagctaaat
    13921 cagcttactt aagaagtata ctatattcag aaaaacttgt caagtttcct tagaaatttt
    13981 ccataggaaa aagccaggta agaactacct agcttatctt cttctattta cttaaatcaa
    14041 ttcgacgacc aattttacca ataataatcg ctccaataat caatgaagca aattcaccga
    14101 ttcctgttgt aaaccaagta aggaagaatg gtaattctgc tacaatattt aactctgcag
    14161 cgatagtaaa catggaaatt gaaaagagga ttgaaaagaa gaaatgatct tttcgaatca
    14221 atccgttaaa gaggtaatcc ttgctatatt ttgcaaaaag ccaaacacct aaactgagga
    14281 atactaaggt tgaaccacca ccaacaaaga catctagcag tccgaagcta aagaaattag
    14341 caatcataca accgatggta actccgatga tgtacttagg attgtaaaaa gccataaagt
    14401 tcatcatttc tgaaatacga aactgataag caccatagct gatggcattt aggggcggtg
    14461 tgacagtcaa aacgacgtag atagcagcga cgattgcaat atctgcaaca tcacgaatag
    14521 ttaatttttt catcttttct cctttggcgg ttatccgcgt gtaatatgct tggtgaaaga
    14581 agctaagcac caagggttga ttcattcaac cttactagta tagcacaata gcctgcttta
    14641 tgctatactt aaagcatgaa aaaacctatt caaaaatttt ttaacaatga aatcttagcc
    14701 tatctctttt ttggccttgc gacaactcta gtttcgattc tctcacgact agtcatttat
    14761 caactaagtc atcaggaact ccttgctacg gccttggcaa atattatcgg tatcttattt
    14821 gcctttatca caaatgatac gattgtattt aagcaaaaaa agaaaaatag acttatccgt
    14881 ttagtgaaat tttctcttgc tcgcctttct acttttctgt tagacttgtt tttaactttt
    14941 ctctttgtaa cccaatttcc tcacattata gggcaattcg taactgaaaa cattgataag
    15001 ataaatgcta ttgaaacaat aattgcacaa atattcatta ttatcatcaa ttatatcttg
    15061 agcaaggtct atatttttag aaaataatgc tccatttatg agccttttaa ttgccttcta
    15121 taatgattta ggatacaatg aaacacgaaa cattgaaagg aaaacagtat gttaaaaaat
    15181 ctaaaatcgt tcttgcttcg aggaaatgtt attgaccttg ctgtcggtgt tgtcattgcc
    15241 tctgcttttg gtgctatcgt tacttcactt gtaaacgaca ttatcactcc tcttatttta
    15301 aatcccgctt tgaaaactgc taaagtcgaa cgtatcgctc aactttcttg gcatggagtc
    15361 ggctatggta actttttaag tgctattatc aattttatct ttgtgggtac cgccctcttc
    15421 tttattatca agggcattga aaaagcacag aaactgactg gcataaagga agaaaaaact
    15481 gccgaaaaaa aaccaaccga attggaagtc cttcaagaaa taaaagctct ccttgagaaa
    15541 aaataatcga ttaaaaggat ctagcgcaaa gctaaatcct tttttcttta ctctttgggt
    15601 aacttgcctg ctttttcaag cattttcttg atcagataag gcatcttaac attttcacga
    15661 ccttttttct caatgagttt tttgacaaat tctggcatct gaaggtcgtc tgtctctttc
    15721 atgatgtcct tggtagttgc cgaaggcgct aactcatcaa aggtttcttc ttctgggaga
    15781 aaagttttaa attctttgtc ttcgttggct cttacagtag caactaaagc gtcaattaaa
    15841 cggctatccg tattgggcat cggtggacga tggtaagtga cacctaattc ttgacacaaa
    15901 tcataacatt ccacatcatt atcgaacaag acttcgatgt gctcactgat aaagctaatc
    15961 ggaacaaaaa tataatgttc tggatgttgc ttttgttctc gtaaatattc taagacatct
    16021 ggcttgatcc aagggattcc aatatcgctt tcgctctgcc aagtattggt atactggtct
    16081 gtcattaggc ctagttgttc agcaatgagc ctgctattat cgaaaatctg atcgatataa
    16141 ggatctccat agtccaaggc aaaaatggga acgctatggg ctgaaaagat taccttgaag
    16201 gattcttctc ccacctcatt tcgtaaaatt tttctaatct catctgtcca gaagtccagc
    16261 aaagactgtt gttgatacca gtccttaata actaaaaatc ggatctgctg gctttccaga
    16321 aacttttcat accccatgac tgagtaaaaa gaataatgag gttccaaaat caagcagata
    16381 cattcttcaa caccatcagt ttccatctgc ttgatcacgt ctggaataaa gggacgagaa
    16441 aatttgttgg caaagtagat accgtactcc tcccctaaac gttctttgac taaattgacc
    16501 tcctcacgtg taatccgctg caaaggcgtc ccaccgatac gaatatagtt gtcatagaga
    16561 gtctggattt cgtggtcttg gggtctaact ccacgacgaa tgtttgtaaa gaattctgct
    16621 actccttcaa aactaatctc ctctggagat ccaaaggtca tcattaatat ggcttttttc
    16681 atgttatcat ccttatgata ttattttctc tatccattct atcatgaaag aaaaaaatag
    16741 taaacgtttc ctacgtctac tatttctttt gctcttttgt ttttttatct cgtcttataa
    16801 ttaggatgat aaggacaaga agtgggaatt ccgtgatcga aataccgtgt tcctactgct
    16861 tccccacttt catcctgtgc tactttcacc ggtgcatccg ttattttagc taaaaggata
    16921 tgtcgtccat tagttatgtt aaggaaacag gtgcttaata aaacaatctt gtccgttgag
    16981 gtcaaggaaa catctcgctt gtacttggct ttacttagca gatattgata gtaagcctgg
    17041 tgttcctcat ccttggaact caaggttcga taaatctccg tgtcataggc atccacttct
    17101 aaaatcccaa aaatttcaag accacgttct cgaccattgt agtagataga accgtagcga
    17161 tgctggtcga agaattcctt atcagcaaat ttcttaatct caccgaacat agcccctgaa
    17221 gccatagagt gtccgtagat gatcgtatta aaatcagtaa agttgggatt aaagcgatag
    17281 tcgagaaaaa ttgatcccgt tatcgtataa tcgccaaagg cattgcggtc aaggtatttg
    17341 acattatcct gactttgtag aagcggatag tctaccttgg tcccatcaag gctaatccaa
    17401 ccgcaaacat ctttgttcaa gtgctgtagg gtttcaaaac ctgtgctcga agcatccttt
    17461 tcaataggat tatagtgatc atagtcactt gcttctacta ctctctgcca actaaaaaga
    17521 gctacaaaaa cacagaagaa taccagaaat acgtttttaa atcgcgctct tttgaaccgt
    17581 catcagcact cctttctatg cgagatttct taaaaggaaa ggaggcggga caaaaccgcc
    17641 tcttttctat tcacccttag tcagtaaaag ggtctgcttc ttgcattttt tttactctct
    17701 cttctacgac gtaggatcaa gtagaggaca aggagtaaga aaatcaagag caagaacaat
    17761 acaaacaaga taaggtacca aatccatagt gggattgatg agaggaaacg tccaagagac
    17821 gagtcatcaa agacactgta tggaaatggt tttgattttt ttgtatggaa agtattttta
    17881 gggacagtgt ctgtaatctt tgcgactacg atatgacgac cattggtcac atcgagaaaa
    17941 caggtactga gtaggatgat acgatcactc ggtgagagtg agatatcccg cttgtgcatg
    18001 gcgactgaga gcaggtggtc tagataggcc tgctggcggt cctcaccctg tattcctgga
    18061 tcatagatgt taaagtcata ggcatcaacc tccaacatct caaagatctc gagccctttt
    18121 tccacaccat tgtagtatat actaccgtaa cgatgctggt caaaaaattc ctgatcagca
    18181 aacttagcca catcaccaaa catgacccca ttttctacgt ggtgcccgta gataatggta
    18241 ttaaagtctt cgaacttagg attatttcgt gcatcgagaa agatagcgcc tgtcgctgca
    18301 aactcacctt tggagtcctt gttgagatac ttttcattgt ccttggcttg gactaaggga
    18361 tagtcgatat tggtgccgta gacattgatc caaccgagga cttcgggatt gagttcttgg
    18421 agtttgctga agcctgaaaa actggccagc tcatcctgtt gcgtcgtgac aggtcgataa
    18481 gcttcgtact cacttgacga agctaaggag tagacttggt tggaatccca aagggcgtag
    18541 aaaccaaaga gaaagatcaa agctgcaaaa atgagcagca agtgattgat caccccatcc
    18601 acagcaagaa cgagacgcct agacagactc ttttttggtt tctcacgctt ggttttcatc
    18661 atctgccccc agccgtttag gcttctctac gttttttaga caagacaaca aatccagcca
    18721 aaccaagacc aatcatcaaa atgaatggaa ggttatcaat caagagacca gtaggagtaa
    18781 cgtcgtcgat tttgttagta actttgttgt cgtttttctt ttcacctatg aggatatctg
    18841 ttaatgtaaa atctacattt ttttgtcctt gagatgtttg ttctgcacca tttgtagtat
    18901 aaattgatga atctgtataa cctgctactc cagtttcagt tactgtatat ttagaacctg
    18961 ctggtagttg ttcaactgta aatgtttcac catctttaag agtaaaattg tactcaactg
    19021 tatctgctgg ggtcactact gccaacacct ctgacttaga tccatgtttt actataatat
    19081 tcgtaacagg ggtttctgct gttttatttg tacttggaag ttgaatcttg atatggaatt
    19141 ggaaatctct tgttttatcc cctgaagctc catcaacttt tttagtaatt gttaatgctt
    19201 tcgcattggg gtctacttga ctcggatcat caggattagg ctccttactt gcgtctttgg
    19261 tatatgtgtt atcaaataaa ttataaacgc cttgttcact tggttctact ttaggggcgt
    19321 tagatttatt attttcctta aagtatactg atgaaatata gacaccacca tttactttat
    19381 tcttaacaat aacgtgcatt tcatatgtac gtttgtcgta tctcatggca tcaattgttt
    19441 taccattttt ggtaatcgcc tgccatccag tttttgcttc cgctacatca taaacgtatt
    19501 caccagcatg gccataagca actcccgaaa aaatgtcttc tgttgctttt tgaatcttat
    19561 cagcagttgg gtgatcattt ttattgtatt ctacatttct atctggaatt gcaactccgg
    19621 tttgatatgg cgcaccgtta gaagattgtc ctgttttttc tgtaaactta aatgtaaatg
    19681 tcgctgttgg tgttgttatt ccctctgcaa tattcaacgt tttattaatc ttcacaacag
    19741 cattattttc accatttgct ttggttattg ctgaattatc atccgcaaaa gtcgggacac
    19801 ctctgaatac ggacaaagcg gttatagctg caatgcttgc agtgaatagc tttttaaaga
    19861 atgttttttt catgattatt tcttttgttt ttttattttc ttttttcatt atgatcatca
    19921 aaagcctcgt cttctaatta ctgttacaac ttttccttga gtatcctgta tagggatggt
    19981 tccaaaagca cgactgtcta cagccgttgt tcgattgtcc ccgaggacaa aaagttgtcc
    20041 tgctgggact ttcatcgaga aggttgcccc ttccttatag agcagcgttt ctttgtagat
    20101 atcttgctct tgttgaggag aaccgttgat gatgagacca ttttcgttta tatcgattgt
    20161 acttccttcg gttgctatga cacgcgccac tctttcctta cctttataac tatagactag
    20221 caaatcacca atcgaatagc gtttatccaa cctataatag acgaccaagt cgccatcttt
    20281 taaggcgggc ttcatgccat cgtcattgta tcttaataat ccaaagacga aaaagtaaag
    20341 ggtggctagt acaaatccaa ccatcagaag tttactgact aagtaaagga tatctcccca
    20401 gacactcggc ggagacttat cccgattgac ttgtgttact ggtttcttat gtttcttttt
    20461 aagcagcatc acttcctcct attcaccaca aggtgaccaa gtaagatgat aaagaagatc
    20521 cctcctagag gaagaacgac tccaagcacg agagtgctac tcaagaagtc aattcccgtt
    20581 tcaggtacgc tgtttttatt attcgtgact gtcgcagact tatttgcatc aagagttcct
    20641 tcttttttat cataggacac ctgataccca cgagacgaac ttgcttcttc ttcgatacta
    20701 taacgagcat ttagaggaag gtcgagaatc ttgatggttt tatctttctt tagatcaact
    20761 gtcgccttac cattggtgaa ttgtagcgtt gttttttgat tatttactat tgcactatac
    20821 gatccattca atggtttatt ttgcgcatcc tttacgttaa tggtaatctt aaaggattgc
    20881 agaagattag caaaagcacc tgtaactttt tttgtgactg aaagtgtcgg aagtctgtgg
    20941 ttggtgacga ttgtttgaac atcctctgac aaagtcccct cttgtttttc ataggtgaca
    21001 tgatatcccg ttctagagtt ctctacttct tccaccttat agtgggtatc acgaggcaga
    21061 taactgaggg cagtttcctg actatttttg agagaaatct gtgctttccc gttagtcact
    21121 gttgtattcc caaacttgcc gttaatcggc ttgccatcct tatctgaaag ggtaacatta
    21181 attgtgaaag atttattagg tgattgttca ccttctagga ttttctttac ggtgagactt
    21241 ggaagctgtc ggtaaataac tttgaaggat ggtttctctt tcgtacctgt cttttgaact
    21301 tcgactgtgt atcccggagc gtctggtgct ttcagttcgt agtcatatcc cttagctacc
    21361 tttgcaaaac tagtattttc agtaaaacta ttcgtttgaa ctggactagt gacctttcga
    21421 taggaatcct ttatacttcc atctttcttt tggtttaagt ttaattcgac actaggtgga
    21481 cgatttgctg atggatttga ttttccatcc acacctttcc actcaatctc tacaggaacc
    21541 gtcaatggat ctgacggctt gaaagtgggc ttctcagaat agtcttttat tttggtacgt
    21601 gaggtcccaa taccatagga ataggcaact tttgccccct tgttggagta gagtttagta
    21661 gcatcggctt cttcggcatc atcactagta agtgtcttat cacccgcaat cgcatcaaat
    21721 gcctcttggc tagaggtgac agtaaacttg agaacgtact tggcgtcatc ctccaaagtg
    21781 taactcggat taaacttggc tgttacttcc actaatccct gttcgttctt cttagtttca
    21841 atcgtaactt gattgtcatt cagttcttgc tcgttaccat ccttgatttt gacgacacga
    21901 aggtgtgaag catcaccagg taacagctgc acgtacttgg acaagacatc tgatatagtt
    21961 acatggtgta cgcctagagg tagaatttta tctgtgattt ctttgaattt ttgttgcaag
    22021 tcattttcat tattggcaga aaatatttcg ttggggattc cagaattata accactgata
    22081 tatcctttaa gagatgtgat actatcgttt gaacctatat atctgaattt gattgaataa
    22141 aagccatcta tttttggagc tattaaacta gatatattca gcattcctct ctctaaacca
    22201 gaggtaaacc aatatggagt atcaatcata cgtcccacat ttggattaga ataatagtta
    22261 tatattgttc tcccactatt agactcgtaa tacatattag cttcgccatc tgacagcaga
    22321 ataactactt tttttgcccc agcccttgca ctttgcaaca atctttgagc ttcagttaac
    22381 ccagcattta tatttgtccc agtgccaatg cccgcgtcca taccataaga atgactagag
    22441 tcagcaattg ttaacgaact aacaatattt tttgagctat tagaatccgt gctccaagat
    22501 actaaagttt tagcatcatc atatgaagag atatttgaat accaaccagc tcaatttggc
    22561 caagttccat attgataact cagataatat tcattataat aacggccatt atactgatta
    22621 tcaatctttc cggcaaaacc aactatagac agacggtttt gggaattaga aagaattgta
    22681 tcaatgagcc cctgacgacc attcacacct ttcagtgtat gttttagtgc ttcaatccta
    22741 ctaatgtatc gtctactaga gtaagaccac acatctcgct cttccatact ccctgaaaaa
    22801 tcggcaacca agactacatc caagggttct gactgggtct ccgttcccag tttagatgtg
    22861 atatccagtg acaactcata ctggtcttct tgccctgata tcggagtaat cgttttgtgc
    22921 agagttgtct gaggttcagt tgttgaatct gcacgtaaag aattaattgg tgcacacaaa
    22981 aaaagaatag cgagaaagat aactaaacta ctggtaaaat attgaatctt cttaaaatca
    23041 tattgaacgt tcatgctatc tcccttgcta gaatatgttt
//
LOCUS       DAVHIZ010000029        21591 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.031, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000029 DAVHIZ010000000
VERSION     DAVHIZ010000029.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 21591)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 21591)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..21591
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.031"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(267..1463)
                     /gene="tuf"
                     /locus_tag="VVO18_001248"
     CDS             complement(267..1463)
                     /gene="tuf"
                     /locus_tag="VVO18_001248"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014335040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor Tu"
                     /protein_id="HEU5586407.1"
                     /translation="MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSSV
                     NQPKDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQM
                     DGAILVVASTDGPMPQTREHILLSRQVGVKHLIVFMNKVDLVDDEELLELVEMEIRDL
                     LSEYDFPGDDLPVIQGSALKALEGDSKYEDIVMELMNTVDEYIPEPERDTDKPLLLPV
                     EDVFSITGRGTVASGRIDRGIVKVNDEIEIVGIKEETQKAVVTGVEMFRKQLDEGLAG
                     DNVGVLLRGVQRDEIERGQVIAKPGSINPHTKFKGEVYILTKEEGGRHTPFFNNYRPQ
                     FYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGM
                     VTEIEA"
     gene            complement(2374..3243)
                     /locus_tag="VVO18_001249"
     CDS             complement(2374..3243)
                     /locus_tag="VVO18_001249"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000348128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEU5586408.1"
                     /translation="MDFTWALKYATEFLGTAILIILGNGAVANVELKGTKGHQSGWIV
                     IAVGYGMGVMIPALMFGNVSGNHINPAFTLGLAVSGLFPWAQVVPYIIAQVLGAIFGQ
                     ALVVATYRPFYLKTEKPNNILGTFSTISSIDHGTKESRYAATVNGLINEFVGSFVLFF
                     AALGLTKNFFGAEVLQFMKQKAIEAGQTVDFSDLAIKAQVAPHTASGLSVAHLALGFL
                     VMALVTSLGGPTGPALNPARDLGPRLLHAFLPKSVLGEHKGDSKWWYSWVPVVAPIAA
                     AIAAVAVFKFLYL"
     gene            complement(3466..3987)
                     /locus_tag="VVO18_001250"
     CDS             complement(3466..3987)
                     /locus_tag="VVO18_001250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU5586409.1"
                     /translation="MVPKTATSTETKTITRIIHYVDKVTNQNVKEDVVQPVTLSRTKT
                     ENKVTGVVTYGEWTTGNWDEVISGKIDKYKDPDIPTVESQEVTSDSSDKEITVRYDRL
                     STPDKPTPEPGTPKTETPVNPDPEVPTYETGKREELPNTGTEANATLASAGIMTLLAG
                     LGLGFFKKKEDKK"
     gene            complement(3959..5050)
                     /locus_tag="VVO18_001251"
     CDS             complement(3959..5050)
                     /locus_tag="VVO18_001251"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MucBP domain-containing protein"
                     /protein_id="HEU5586410.1"
                     /translation="MNIILIAKLLRENTNTKANALNNGWARSGSEEFKKFSHFVGVDK
                     GIVRTNVLTGKKLSDKIRKEVGSGDSKLGKGGYFSTGDVLLGKDVVSYTVQVFSENNE
                     RVGVNTQSHRVQYNLPILADFSVIQDTVEPSRTVVEKIIPKLNIPEEEKGKITEEIKK
                     KKKTSELAELISENVKVRYVDEQGRLLSLKNDTGIGEKESDGTYITNKKQLIGTSYNV
                     TDKKLSSMTTTDGKYYTFKEADTNSASLTGNIVSEGRTVTLVYRESEAPTTATVTANY
                     YKEGSQEKLAESVIKADLAIGSEYTTESKTIEGKTTTEDKEDRVITRKTTYTLVATPA
                     NAYQKTVQQLTIITVRMLRKSGSQNSNLY"
     gene            complement(5161..5415)
                     /locus_tag="VVO18_001252"
     CDS             complement(5161..5415)
                     /locus_tag="VVO18_001252"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586411.1"
                     /translation="MLNVDQDFMSISKSNKSGSDWKKTFTVRTTNRLANDLNNVLKQA
                     DKDTPNTPTWLNSAASKAKDDDRAYKLLKTLIPGENYLSC"
     gene            complement(5755..6288)
                     /locus_tag="VVO18_001253"
     CDS             complement(5755..6288)
                     /locus_tag="VVO18_001253"
                     /inference="COORDINATES: protein motif:HMM:NF024751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
                     /protein_id="HEU5586412.1"
                     /translation="MTSFKEQEPEKVAEFLDILDNLKDLPIVYIDETGIDRYLYRPYA
                     GAPRGEKVYEKISGRRFERTSIVAGQVDGEFIAPMIYKKSMTSDFFVEWFKTQLLPAL
                     KTPHVIVMGNASFHPKNILDELCIQDKHFFLPLPPYSPDLNPIEQAWAILKKKVTDLL
                     REVPTIFECLERFFKTR"
     gene            complement(6275..6490)
                     /locus_tag="VVO18_001254"
     CDS             complement(6275..6490)
                     /locus_tag="VVO18_001254"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808732.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5586413.1"
                     /translation="MGKERCEQGHIERKKRVVKNRKIPLEELKAFVEAHPDAFLREIA
                     AHFDCAVPSVWAALKQIKVTLKKDDEL"
     gene            complement(6457..6600)
                     /locus_tag="VVO18_001255"
     CDS             complement(6457..6600)
                     /locus_tag="VVO18_001255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tnpB"
                     /protein_id="HEU5586414.1"
                     /translation="MAYSTDFKQRALDYIKEGHSHVEAAKFFGVGVRTLFTWEKKDVN
                     KDT"
     gene            6834..8552
                     /locus_tag="VVO18_001256"
     CDS             6834..8552
                     /locus_tag="VVO18_001256"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252698.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phospho-sugar mutase"
                     /protein_id="HEU5586415.1"
                     /translation="MSYQENYQKWVDFVELPDYLRQDLENMDEKTKEDAFYTNLEFGT
                     AGMRGLVGAGTNRINIYVVRQATEGLARLIESKGGNEKERGVAIAYDSRHFSPEFAFE
                     SAAVLAKHGIKSYVFESLRPTPELSFAVRHLNCFAGIMVTASHNPAPFNGYKVYGEDG
                     GQMPPHDADALTTYIRAIENPFAVEVADVETEKASGLIEVIGEAVDVEYLKEVKDVNI
                     NPALIEEFGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQATADPDFSTVTSP
                     NPESQAAFALAEELGRQVGADVLVATDPDADRVGVEVLQKDGSYLNLSGNQIGAIMAK
                     YILEAHKNAGTLPENAALCKSIVSTDLVTKIAESYGATMFNVLTGFKFIAEKIQEFEE
                     KHNHTYMMGFEESFGYLIKPFVRDKDAIQAVLVVAELAAYYRSRGLTLADGIEEIYKE
                     YGYYAEKTISVTLSGVDGAEQIKAIMAKFRNNAPTEWNATAITVVEDFKAQTATVADG
                     TVTNLTTPPSDVLKYTLADGSWIAVRPSGTEPKIKFYIAVVGETNEESQAKITNIEAE
                     INAFVK"
     gene            8663..9010
                     /locus_tag="VVO18_001257"
     CDS             8663..9010
                     /locus_tag="VVO18_001257"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000434646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEU5586416.1"
                     /translation="MEQFLDNIKDLEVTTVVRAQEALDKKETATFFIGRKTCPYCRKF
                     AGTLSGVVAETKAHIYFINSEEPSQLNDLQAFRSRYGIPTVPGFIHITDGQINVRCDS
                     SMSAQEIKDFAGL"
     gene            complement(9289..10125)
                     /locus_tag="VVO18_001258"
     CDS             complement(9289..10125)
                     /locus_tag="VVO18_001258"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586417.1"
                     /translation="MKKWMLVLVSLMTALFLVACGKNSSETSGDNWSKYQSNKSITIG
                     FDSTFVPMGFAQKDGSYAGFDIDLATAVFEKYGITVNWQPIDWDLKEAELTKGTIDLI
                     WNGYSATDERREKVAFSNSYMKNEQVLVTKKSSGITTAKDMTGKTLGAQAGSSGYADF
                     EANPEILKNIVANKEANQYQTFNEALIDLKNDRIDGLLIDRVYANYYLEAEGVLNDYN
                     VFTVGLETEAFAVGSRKEDTTLVKKINEAFSSLYKDGKFQEISQKWFGEDVATKEVKE
                     GQ"
     gene            complement(10138..10767)
                     /locus_tag="VVO18_001259"
     CDS             complement(10138..10767)
                     /locus_tag="VVO18_001259"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000891751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5586418.1"
                     /translation="MLELRNINKVFGDKQILSDFSLSIPEKQILAIVGPSGGGKTTLL
                     RMLAGLETIDSGQIFYNGQPLELDELQKRNLLGFVFQDFQLFPHLSVLENLTLSPVKT
                     MGMKQEEAEKKASGLLEQLGLGGHAEAYPFSLSGGQKQRVALARAMMIDPEIIGYDEP
                     TSALDPELRLEVEKLILQNRELGMTQIVVTHDLQFAENIADVLLKVEPK"
     gene            complement(10777..11418)
                     /locus_tag="VVO18_001260"
     CDS             complement(10777..11418)
                     /locus_tag="VVO18_001260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5586419.1"
                     /translation="MSYLFEILPSLLNGASTTVQVFALVLLFSIPLGVLIAFALQVHW
                     KPLHYLINIYIWVMRGTPLLLQLIFIYYVLPSIGIRLDRLPAAIIAFVLNYAAYFAEI
                     FRGGIDTIPRGQYEAAKVLKFSPFDRVRYIILPQVTKIVLPSVFNEVMSLVKDTSLVY
                     ALGISDLILASRTAANRDASLVPMFLAGAIYLILIGIVTIISKKVEKKYSYYR"
     gene            complement(11564..12793)
                     /locus_tag="VVO18_001261"
     CDS             complement(11564..12793)
                     /locus_tag="VVO18_001261"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864303.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetratricopeptide repeat protein"
                     /protein_id="HEU5586420.1"
                     /translation="MNNSQQMLQALEEQDLTKAEHYFAKALENDSSDLLYELATYLEG
                     IGFYPQAKEIYLKIVEDFPEVHLNLAAIASEDGQIEEAFTYLEEIQADSDWYVSSLVL
                     KADLYQLEGLTDVAREKLLEALTYSEDSLLILGLAELDSELENYQAAIQAYAQLDNRS
                     IYEQTGISTYQRIGFAYAQLGKFETATEFLEKALELEYDDLTAFELASLYFDQEEYQK
                     ATLYFKQLDTISPDFEGYEYGYSQALHKEHQVQEALHIAKQGLEKNPFETRLLLAASQ
                     FSYELHDASGAENYLLTAKEDAEDTEEILLRLATIYLEQERYEDILDLQSEEPENLLT
                     KWMIARSYQEMDDLDTAYEHYQELTGDLKDNPEFLEHYIYLLRELGHFEEAKVHAHTY
                     LKLVPDDVQMQELFERL"
     gene            complement(12783..13949)
                     /locus_tag="VVO18_001262"
     CDS             complement(12783..13949)
                     /locus_tag="VVO18_001262"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435446.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AI-2E family transporter"
                     /protein_id="HEU5586421.1"
                     /translation="MEQKEKHFSLSWFFKWFLDNKAITVFLVTLLLGLNLFILSKISF
                     LFSPVLDFLAVVMLPVILSGLLYYLLNPIVDWMEKHKVNRVIAITIVFVIIALFIIWG
                     LAVAIPNLQRQVLTFARNVPVYLEDIDRIVNGLVAQHLPDDFRPQLEQVLTNFSSQAT
                     VLASKVSSQAVNWVSAFISGASQVIVALIIVPFMLFYLLRDGKGLRNYLTQFIPRKLK
                     EPVGQVLSDVNQQLSNYVRGQVTVAIIVAVMFIIFFKIIGLRYAVTLGVTAGILNLVP
                     YLGSFLAMLPALVLGLIAGPVMLLKVVIVFIVEQTIEGRFVSPLILGSQLNIHPINVL
                     FVLLTSGSMFGIWGVLLGIPVYASAKVVISAIFEWYKVVSGLYELEGEEVKSEQ"
     gene            14093..15106
                     /locus_tag="VVO18_001263"
     CDS             14093..15106
                     /locus_tag="VVO18_001263"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000665618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactonase family protein"
                     /protein_id="HEU5586422.1"
                     /translation="MKETVYFGTYTRRTSQGIYKADFDTETGQLSNLELFAAEPSPTY
                     LAFDQHQHLYTVGSQDDKGGIAAYQTDGTVLNHVVEEGAPHCYVAVDEKRDLVYAANY
                     HKGQVLVYKRQEDGSLLLSDMDQHSGQGPHENQASPHVHYTDLTPDHYLVTCDLGTDQ
                     VITYDLDQEGKLSKLYTYHSKPGAGSRHIIFHNHYKIAYLICELNSTIEVLIYDGVGE
                     FVRMQVISTLPEAYEGFNGTAAIHLSKDGKYLYASNRGHDSIAVYTILADGSLELLEI
                     VPTHGQTPRDFDLTPDQKFLIVVHQDSDNATVFKRNCDNGRLAELSNDFHVPEAVCIR
                     FAP"
     gene            complement(15151..15570)
                     /locus_tag="VVO18_001264"
     CDS             complement(15151..15570)
                     /locus_tag="VVO18_001264"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397408.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="HEU5586423.1"
                     /translation="MAQLTVQIVTPDGLVYDHHASYVSVRTLDGEMGILPRHENMIAV
                     LAVDEVKVKRIDDKDHVNWIAVNGGVIEIANDMITIVADSAERARDIDISRAERAKLR
                     AERAIEEAQDKHLIDQERRAKIALQRAINRINVGNRL"
     gene            complement(15581..16987)
                     /gene="atpD"
                     /locus_tag="VVO18_001265"
     CDS             complement(15581..16987)
                     /gene="atpD"
                     /locus_tag="VVO18_001265"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit beta"
                     /protein_id="HEU5586424.1"
                     /translation="MSSGKIAQVIGPVVDVLFAAGEKLPEINNALVVYKNDERKTKIV
                     LEVALELGDGMVRTISMESTDGLTRGMEVLDTGRPISVPVGKETLGRVFNVLGDTIDL
                     EAPFTEDAERQPIHKKAPTFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVG
                     KTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEP
                     PGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQP
                     TLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLVQ
                     LGIYPAVDPLASSSRALAPEIVGEEHYAVAAEVKRVLQRYHELQDIIAILGMDELSDE
                     EKTLVARARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILDGKYDHLPEDAF
                     RGVGSIEDVIAKAEKMGF"
     gene            complement(17073..17951)
                     /locus_tag="VVO18_001266"
     CDS             complement(17073..17951)
                     /locus_tag="VVO18_001266"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002895995.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit gamma"
                     /protein_id="HEU5586425.1"
                     /translation="MAVSLNDIKTKIASTKNTSQITNAMQMVSAAKLGRSEEAARNFQ
                     VYAQKVRKLLTDILHGNGAGASTNPMLISRSVKKTGYIVITSDRGLVGGYNSSILKAV
                     MELKEEYHPDGKGFEMICIGGMGADFFKARGIQPLYELRGLADQPSFDQVRKIISKTV
                     EMYQNELFDELYVCYNHHVNTLTSQMRVEQMLPIVDLDPNEADEEYSLTFELETSREE
                     ILEQLLPQFAESMIYGAIIDAKTAENAAGMTAMQTATDNAKKVINDLTIQYNRARQAA
                     ITQEITEIVAGASALE"
     gene            complement(17967..19472)
                     /locus_tag="VVO18_001267"
     CDS             complement(17967..19472)
                     /locus_tag="VVO18_001267"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011889023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit alpha"
                     /protein_id="HEU5586426.1"
                     /translation="MAINAQEISALIKQQIENFKPNFDVTETGVVTYIGDGIARAHGL
                     ENVMSGELLNFENGSYGMAQNLESTDVGIIILGDFTDIREGDTIRRTGKIMEVPVGES
                     LIGRVVDPLGRPVDGLGEIHTDKTRPVEAPAPGVMQRKSVSEPLQTGLKAIDALVPIG
                     RGQRELIIGDRQTGKTTIAIDTILNQKDQDMICIYVAIGQKESTVRTQVETLRQYGAL
                     DYTIVVTASASQPSPLLFLAPYAGVAMAEEFMYQGKHVLIVYDDLSKQAVAYRELSLL
                     LRRPPGREAFPGDVFYLHSRLLERSAKVSDELGGGSITALPFIETQAGDISAYIATNV
                     ISITDGQIFLGDGLFNAGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRIDLASYREL
                     EAFTKFGSDLDAATQAKLNRGRRTVEVLKQPVHKPLPVEKQVTILYALTHGFLDTVPV
                     DDIVRFEEEFHAFFDAQHPEILETIRDTKDLPEEAVLDAAITEFLNQSSFQ"
     gene            complement(19487..20023)
                     /locus_tag="VVO18_001268"
     CDS             complement(19487..20023)
                     /locus_tag="VVO18_001268"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358986.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit delta"
                     /protein_id="HEU5586427.1"
                     /translation="MDKKTVKVIEKYSMPFVQLVLEKGEEDRIFSDLTQIKQVVEKTG
                     LPSFLKQVAVDESDKEKTIAFFQDSVSPLLQNFIQVLAYNHRANLFYDVLVDCLNRLE
                     KETNRFEVTITSAHPLTDEQKTRLLPLIEKKMSLKVRSVKEQIDESLIGGFVIFANHK
                     TIDVSIKQQLKVVKENLK"
     gene            complement(20023..20517)
                     /gene="atpF"
                     /locus_tag="VVO18_001269"
     CDS             complement(20023..20517)
                     /gene="atpF"
                     /locus_tag="VVO18_001269"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006145707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit B"
                     /protein_id="HEU5586428.1"
                     /translation="MHVTVGELIGNFILITGSFILLLVLIKKFAWSNITGIFEERAEK
                     IASDIDRAEEARQKAEVLAQKREDELAGSRKEAKTIIENAKETAEQSKANILADAKLE
                     AGHLKEKANQEIAQNKVEALQSVKGEVADLTISLAGKIISQNLDSHAHKALIDQYIDQ
                     LGEA"
     gene            complement(20531..21247)
                     /gene="atpB"
                     /locus_tag="VVO18_001270"
     CDS             complement(20531..21247)
                     /gene="atpB"
                     /locus_tag="VVO18_001270"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit A"
                     /protein_id="HEU5586429.1"
                     /translation="MEESINPIISIGPVIFNLTMLAMTLLIVGVIFVFIYWASRNMTL
                     KPKGKQNVLEYVYDFVIGFTEPNIGSRYMKDYSLFFLCLFLFMVIANNLGLMTKLQTI
                     DGTNWWSSPTANLQYDLTLSFLVILLTHIESVRRRGFKKSIKSFMSPVFVIPMNILEE
                     FTNFLSLALRIFGNIFAGEVMTSLLLLLSHQAIYWYPVAFGANLAWTAFSVFISCIQA
                     YVFTLLTSVYLGNKINIEEE"
     gene            complement(21282..21482)
                     /locus_tag="VVO18_001271"
     CDS             complement(21282..21482)
                     /locus_tag="VVO18_001271"
                     /EC_number="7.1.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015545704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="F0F1 ATP synthase subunit C"
                     /protein_id="HEU5586430.1"
                     /translation="MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLM
                     FLGVAFIEGTFFVTLVFSFIIK"
BASE COUNT         6463 a         4661 c         3921 g         6546 t
ORIGIN      
        1 tacaacctaa aaacagtgtt ttgagcagtc tgcagctaac tttctataac aaaatgaaat
       61 aagaacaaga caaatcaatc aagataatca aatcgatttc taacaatgtt ttagaagtag
      121 atgtgtacta ttctagtttc aatatattat agtttgctct ttgattttca ttgagtatta
      181 gttcaatatc taaaaaaaga accttgccaa gcaagattct tttagtgtct gacttaaata
      241 attgttcttc tgggaactaa atcgaattaa gcttcgattt ctgtaaccat acctgaacca
      301 acagtacgtc caccctcacg gatagagaat gtagtacctt gttctacggc gattgggtga
      361 atcaactcaa cgtcgattgt cacgttatca ccaggcatta ccatttcagt acctgctgga
      421 agttcgattg aacctgtaac gtcagtagta cggaagtaga attgtggacg gtagttgttg
      481 aagaatggag tgtgacgtcc accttcttct ttagtaagga tgtagacttc acctttgaat
      541 ttagtgtgtg ggttgattga acctggttta gcgataactt gtccacgttc gatttcatca
      601 cgttgaacac cacgaagaag gacacctacg ttatctccag caagaccttc gtcaagttgt
      661 ttacggaaca tttcaacacc agtaacaact gctttttgag tttcttcttt gataccaaca
      721 atttcgattt cgtcgttgac tttaacgata ccacggtcga tacgtcctga agcaactgta
      781 ccacgtccag tgattgagaa tacgtcctcg actggaagaa gcaatggttt gtcagtgtca
      841 cgttctggtt ctgggatata ctcatcaact gtgttcatca attccataac gatgtcttcg
      901 tatttagagt caccttcaag agctttaagt gctgaacctt ggataactgg aagatcgtca
      961 cctgggaagt cgtattctga caataggtca cggatttcca tttcaaccaa ttcaagcaat
     1021 tcttcgtcgt caaccaagtc aactttgttc atgaagacga taaggtgttt aacaccaacc
     1081 tgacgtgaaa gaaggatgtg ctcacgagtt tgtggcattg gtccgtcagt tgaagctact
     1141 acaaggatag ctccgtccat ttgagcagca ccagtgatca tgtttttaac gtagtccgcg
     1201 tgtcctggag cgtcgatgtg agcgtagtga cgtttttcag tttcgtactc aacgtgcgca
     1261 gtgttgatag tgataccgcg ttcgcgttct tctggagcag catcgataga cgcatagtct
     1321 ttaggttggt taactgatga aggcaagcga cgtgccaaaa cagttgtgat agctgcagtt
     1381 agggtagttt taccgtggtc aacgtgtccg atagtaccaa tgttaacgtg tggtttacta
     1441 cgatcgtatt tttcttttgc catttgagta aaagcctcca ataaaatata ttttatagat
     1501 agacagtagg caatacagtc taactttcct tactatttta tcaaatttca gctaaattgc
     1561 aagtgtttta caacgttttt gtgaattatt cttggtaaaa atttaactaa ttaatagaaa
     1621 gtactaaata gacttatcct tcaaggagtt ttcagcatta tccatccact cacttgctga
     1681 aaatgtaaac agtctctggt ttatatagta aaatgaaaca agaatagggc aaatcgatca
     1741 ggacagtcaa atcgatttct aacaatgttt tagaagtaga tgtgtactat tctagtttca
     1801 atctactata caacctcaaa actgtgtttt gaacaacctg cggctagctt cttagtttgc
     1861 cctttgattt tcattgagta taaaattgca gataaaacga taacaatcat aggactcagc
     1921 agagtcaatg taggtcgaag aatagccccc ctaatcgctt attttatagc aaaatgaaat
     1981 agaaactgaa cattttgttg aggaaggtaa atcaattcct cacaatgttt gagaaagaag
     2041 gggggactat tccaacttca acccactata aagcagactt acaagatagg gaacccatct
     2101 ccgataatat atagtagaat gaaaactgca caatttgatt ggagaattca aaccaatttc
     2161 taacaatgtt ttagaaacaa gggtctatta tttcaactgc aacctactat agcccattga
     2221 agctggaata gcccactgag acttctaaac cactgctgga gaggagtttg tttagagttt
     2281 ctttcatttc cctaaaaaat caaaaagaga gaaccagtct gatcctctct tacttataga
     2341 tggtgctcac tcaaatgtta aaggagctat ttcttagaga taaaggaatt tgaatacagc
     2401 tactgccgca attgctgctg cgataggtgc tactactggt acccaagaat accaccattt
     2461 tgaatcgcct ttatgctcac caagaactga ttttggaagg aaagcatgaa ggagacgtgg
     2521 tcccaagtca cgggctgggt tcaaggcagg tcctgtaggt cctccaagtg atgttaccaa
     2581 agccataacg aggaatccaa gtgccaagtg agccacagaa agtcctgaag cagtgtgtgg
     2641 agccacctgt gctttaatag ccaagtcaga aaaatcaact gtttgtcctg cttctattgc
     2701 cttttgtttc atgaattgaa gcacttcagc accaaagaag tttttagtca aaccaagagc
     2761 tgcaaagaac aaaacaaatg aaccaacaaa ctcattaatc aaaccattga cagttgctgc
     2821 atagcgactt tcttttgtac catggtcaat acttgaaata gttgagaaag ttcccaagat
     2881 gttatttggt ttttcagttt tcaagtagaa tggacggtat gttgccacaa ctaaggcttg
     2941 gccaaagata gcccccaaga cttgcgcgat aatgtaaggt accacttgtg cccaagggaa
     3001 aagaccgcta actgcaagcc ctagagtgaa agcagggttg atgtgattcc cagatacgtt
     3061 accaaacatc aaggctggga tcataacccc cataccataa ccaacagcga tgacgatcca
     3121 gccactttgg tgacctttcg tacctttaag ttcaacgttg gcaactgcac cattcccaag
     3181 aatgatcaaa atggcagttc ccaaaaattc agtggcatac ttcagtgccc atgtgaaatc
     3241 catttgctag attctcctta aaatttttta gatattcctt attttatcaa tttttaccct
     3301 atttagcaac tgatttctgg aaatattttt aaaaaaatag gattcatagt ttcccagttc
     3361 aacgtacttg taagcgtttt tattcttcac gaaagacctc attctcaaaa ccaggaaaaa
     3421 gcccacatct gtgatctttt ccttgttcct agattctaaa atctattatt ttttatcttc
     3481 ttttttcttg aagaatccta atcctagacc agctaacaag gtcatgatac cagcactagc
     3541 caaggtagca ttagcttctg tacctgtgtt tggcaattcc tctctcttac ctgtctcata
     3601 agtcggaact tctgggtctg gattcactgg agtttcagtt tttggagtac ctggttctgg
     3661 agttggttta tctggtgttg ataaacggtc ataccttacc gttatttctt tatcactaga
     3721 gtctgacgta acttcttgtg attcaactgt tggaatatct ggatctttgt acttgtcaat
     3781 cttaccagat ataacctcgt cccagtttcc tgttgtccat tcaccgtagg ttacaactcc
     3841 cgtgaccttg ttctcagttt ttgtacggct taaggttaca ggttgaacaa catcttcttt
     3901 tacattttgg ttcgtaactt tatcaacgta atgaatgata cgcgttatag tcttcgtctc
     3961 agtagaggtt gctgttttgg gaaccacttt tcctcaacat tctcacggta ataatagtca
     4021 actgttgcac cgtcttctgg tacgcatttg caggagttgc taccaaggtg tatgttgttt
     4081 tccttgtgat aactcggtct tctttgtcct cagttgttgt tttcccttca atagtttttg
     4141 attctgtggt atactcagaa cctatcgcta aatcagcttt tataacagac tctgccaact
     4201 tctcttggct accttcttta tagtaattgg ctgttactgt agcagtggtt ggcgcttcgc
     4261 tttctctata aactaaggtc actgttctac cttcgcttac aatattccca gttaaacttg
     4321 cagaatttgt atctgcttct ttaaaagtat aatattttcc gtcagtagta gtcatgctac
     4381 tgagtttttt atctgtgaca ttgtagctgg taccaatcag ttgtttttta ttggtaatgt
     4441 aggttccgtc actttctttt tctccaattc cagtatcatt tttcaatgat agcaaacgcc
     4501 cttgttcatc aacatagcga actttcacat tttctgagat tagttctgcc aattctgagg
     4561 tttttttctt tttcttgatt tcttcggtta ttttcccttt ctcttcttcg ggaatattta
     4621 gttttggaat gattttttca acaacggttc gtgatggttc cacagtatct tggatgactg
     4681 aaaagtcagc tagaattggg agattatact gaacacggtg actttgagtg tttactccta
     4741 ctctttcatt attctctgaa aatacttgta cggtataaga aacaacatct tttcctaata
     4801 gaacatcccc agtagagaaa tagccgcctt ttcctagttt gctatctcca gagcccactt
     4861 ctttcctaat cttatcagat agttttttac cagtcagtac attcgttcgc acaatccctt
     4921 tgtctacccc tacaaagtgg gagaactttt tgaactcttc agaaccagat ctagcccaac
     4981 cattattaag ggcatttgct tttgtatttg tattctctct caaaagtttg gcgattagaa
     5041 ttatattcat cggcacttag agttgctgct atatctgact cttgaatacc aacttcctta
     5101 ctaccatttc tagcggcagt atatgtgtat ttatttgttt ctacttctag ctgattatcc
     5161 ttaacatgat aggtaatttt ctcctggtat aagagtcttc agtagtttat atgctctgtc
     5221 atcatcttta gctttagaag cagctgagtt tagccaagtt ggggtattag gagtatcttt
     5281 atcagcctgt ttcaagacat tattcaagtc atttgctagc ctattggttg tcctcactgt
     5341 gaaagttttc ttccagtctg aaccactttt attagactta gatatgctca tgaaatcctg
     5401 gtcaacattc aacacaatat cgccttgttt tttagcatct tccgttgctt ctgcttcaaa
     5461 ttgatcatgg aatttttgtt gctctggtgt atagtttttt tatttacacg atttaatgta
     5521 ctatttttta ttttagtatt aagaactcca ttaatacgat ttttaaactc tgcttcaaaa
     5581 aatcccttaa tttgttggtg cgcaagttca acattcaaac ctttcttata caagtcttca
     5641 ttctgaacga tttcggctac acggtgaatg gtttgatcgt ataccgtctt ctcttaacca
     5701 gcagtatcct tagttttaat gactactcga taagttcctt tagaaccgtt atagtcatct
     5761 agttttaaaa aagcgttcca aacattcaaa aatagttgga acttccctta ataaatccgt
     5821 cactttcttt ttcaagatag cccaagcttg ctcaatagga ttcaaatccg gtgaataagg
     5881 tggtagaggt aagaaaaagt gtttatcttg gatgcagagt tcatccaaaa tgttcttggg
     5941 atgaaaacta gcattgccca tgacaataac atgaggtgtc ttcaaagcag gtaggagttg
     6001 cgttttgaac cactccacaa agaaatcgct tgtcatgctt ttcttgtaaa tcatgggagc
     6061 tataaactct ccgtctactt gtcctgcaac aattgaagtt cgctcaaaac gacgtccgct
     6121 aatcttttca tagactttct cccctctagg agcccctgca taaggacgat agaggtagcg
     6181 gtcgattcct gtttcgtcaa tatatacgat tggtaaatct tttaggttat ccaaaatatc
     6241 aagaaactca gcgactttct ctggctcttg ttccttaaag ctcgtcatct ttttttaaag
     6301 tgaccttaat ctgctttaaa gctgcccata ctgaaggaac agcacaatca aaatgtgccg
     6361 caatttcccg taaaaaagca tctggatgag cctctacaaa ggctttcaat tcctctaaag
     6421 gaatctttcg gtttttgacg actcgctttt tcctctctat gtgtccttgt tcacatcttt
     6481 cttttcccac gtgaagagag ttctgacgcc aacaccaaaa aacttggctg cctcgacatg
     6541 gctgtgcccc tctttgatgt aatctaatgc tcgctgttta aaatcagtac tatatgccat
     6601 agctttatta taatatgctt gtttaaaact aagcaactat atcaatgttt tgttattaga
     6661 agacttactt tttttactga aatcgaattt ttcctaacct caacatcata taaccccaaa
     6721 attcaatctg acctggtttg aagagatgtt cgaagcagat aaggttttac taaaactaaa
     6781 aaaaatgata taatcaaact gattaaatgt tttaaaaata aaggagaatt tgaatgtctt
     6841 accaagaaaa ttaccagaaa tgggttgatt ttgtggagct tcctgactac cttcgtcaag
     6901 atttggaaaa tatggacgaa aaaactaagg aagatgcctt ctatacaaat cttgaatttg
     6961 gtactgcagg tatgcgtggc ttggttggtg ctggtacaaa ccgtatcaac atctacgttg
     7021 ttcgccaagc tactgaagga ttggctcgtt tgattgagtc aaaaggtgga aacgagaaag
     7081 aacgcggtgt agcaattgcc tacgatagcc gtcacttctc acctgagttt gcctttgaat
     7141 ctgcggcagt tcttgctaaa cacggcatca aatcttacgt atttgaaagc cttcgtccga
     7201 ctccagaact atcatttgca gttcgtcatc tcaactgttt cgcaggtatc atggtcacag
     7261 ccagccacaa ccctgctcca tttaacggtt acaaggttta cggtgaagac ggtggacaaa
     7321 tgcctccaca cgatgcggac gctttgacta cttatatccg tgcaatcgaa aacccatttg
     7381 cagttgaagt tgctgatgtg gaaactgaaa aagcttctgg cttgattgaa gttatcggcg
     7441 aagctgttga cgtagaatac cttaaagagg ttaaggacgt aaacatcaac ccagccttga
     7501 ttgaagaatt tggtaaagac atgaagattg tctacacacc acttcatggt actggtgaaa
     7561 tgttggctcg tcgtgctctt gcccaagcag gatttgactc tgttcaagtt gttgaagcgc
     7621 aagcaactgc tgacccagac ttctcaactg taacatctcc aaacccagaa agccaagcag
     7681 cctttgccct tgctgaagaa cttggtcgtc aagttggtgc agatgttctt gtcgcaactg
     7741 acccagacgc tgaccgtgtt ggtgttgaag ttcttcaaaa agatggtagc tacctcaacc
     7801 tttcaggtaa ccaaatcggt gctatcatgg ctaaatacat cttggaagct cacaaaaacg
     7861 ctggaactct tcctgaaaat gccgctctct gcaaatctat cgtttcaact gacttggtaa
     7921 cgaagattgc tgaaagctac ggcgcaacta tgttcaacgt cttgacaggt ttcaaattta
     7981 tcgctgaaaa aatccaagaa ttcgaagaaa aacacaacca cacttacatg atgggatttg
     8041 aagaaagctt cggttacttg attaaaccat ttgtacgtga taaagatgcc atccaagccg
     8101 ttcttgtcgt tgctgaactt gctgcctact accgttctcg tggtttgaca cttgctgacg
     8161 gtatcgaaga aatctataaa gaatatggct actacgcaga aaaaacaatc tctgttactc
     8221 tttcaggtgt cgatggtgct gaacaaatca aagcgattat ggctaaattc cgcaacaatg
     8281 ctccaacaga atggaacgca acagctatca ctgtcgtaga agacttcaag gcacaaactg
     8341 ctactgttgc tgacggtact gttacaaact tgacaactcc tccaagtgat gtgttgaaat
     8401 acacacttgc tgacggttca tggattgccg ttcgcccttc aggtacagaa ccaaaaatca
     8461 agttctacat tgcagttgta ggggaaacca acgaagaatc acaagctaag attactaaca
     8521 tcgaagcaga aatcaatgca tttgtaaaat aaagacctat aaaagatgag accaaccaac
     8581 ctcatctttt ttcgtatcaa atctaagcaa ttttagaaac tttatggcat actagactta
     8641 tcaatgaaag cgaggtaatc tcatggaaca atttttagat aacatcaaag accttgaagt
     8701 cactacagtt gtgcgtgcgc aagaagctct tgataaaaaa gaaactgcaa ccttctttat
     8761 cggtcgcaaa acttgccctt actgccgtaa atttgcaggt acattgtcag gtgtcgtagc
     8821 tgaaaccaaa gctcacattt acttcatcaa tagtgaagaa ccaagccaac tcaatgattt
     8881 gcaagcattc cgctcacgtt atggaatccc aactgtacca ggttttattc atattacaga
     8941 tggacaaatc aacgtccgtt gcgactcttc aatgtcagca caagaaatca aagatttcgc
     9001 aggattgtaa aaaatcagct aacaagtctt aaaatcacaa aaacgcataa tgtaaggtgc
     9061 aaaaaccttg atattatgcg ttttattgtt cctaaaacag ttacatcagc atttcattac
     9121 agaacatttt aattttggaa gtcaaatcaa tttttaacaa tgttttagaa atcacagtgg
     9181 gctattccat attcaattat ccagattcaa tcgctattat cgttttccta gattacaaaa
     9241 aaaactacgt tttgctaatc aaaacgtagt ctcagccact attttatctt actgtccttc
     9301 ttttacttct ttggttgcta catcttctcc aaaccatttt tggctgattt cttggaactt
     9361 gccgtccttg taaagactag aaaaagcttc atttatcttc ttaaccaagg ttgtatcttc
     9421 cttacgggat ccaaccgcaa aagcttctgt ttctagtcca actgtaaaga cattataatc
     9481 gtttaaaaca ccttctgctt ctaaataata gtttgcatag acacggtcaa tcaatagacc
     9541 atcaattcga tcgtttttca aatcaatcaa ggcttcatta aaggtttggt attgattcgc
     9601 ttccttatta gcgacaatat tcttcaaaat ttctggattt gcttcaaagt ccgcataacc
     9661 agatgaacca gcttgagctc ctaatgtctt tccagtcata tcctttgcag tcgtgatacc
     9721 agatgatttc ttcgtaacca atacctgctc attcttcata tatgagttac tgaaagccac
     9781 cttttcacgg cgttcgtctg tagcggaata gccattccaa atcagatcaa tcgttccttt
     9841 tgtcaattca gcttctttca aatcccaatc aatcggttgc caatttaccg tgattccgta
     9901 tttttcaaaa acagctgtag ctaaatcaat atcaaatcct gcataagaac catctttctg
     9961 agcaaatccc attggaacaa aagtactatc aaatccaata gtaatagact tgttagactg
    10021 gtactttgac caattatctc cactagtttc gctagaattt ttcccacaag ctactaagaa
    10081 caaagcagtc atcagactga ctaatacaag catccatttt ttcatccatt tttcctccta
    10141 tttaggttct actttcaata atacatctgc gatattttca gcaaactgca aatcatgggt
    10201 aaccacaatc tgggtcatcc caagttccct attttgcaag attagcttct ccacttccaa
    10261 acgtaattct ggatccaggg cagaagttgg ttcatcgtag ccaatgattt ctgggtcaat
    10321 catcatagca cgcgccaaag ccacccgctg cttttgccca ccagatagtg agaaaggata
    10381 ggcctctgcg tgtcctccta gtcctaactg ttccaagagc ccactcgcct tcttctcagc
    10441 ctcttcctgc ttcattccca tggtcttcac aggcgataaa gtcaaatttt ccagaactga
    10501 tagatgagga aatagttgaa aatcttggaa gacaaatccc agtaggttgc gcttctgcaa
    10561 ttcatccagc tctaaaggtt gtccattata aaagatttgc cctgaatcaa tggtttcaag
    10621 acctgcaagc atacgtaaaa gagttgtctt acctccacca gaaggtccaa cgatagccag
    10681 gatttgcttt tcaggaatac ttagactgaa atcagacagg atttgtttgt ctccaaagac
    10741 tttattgata tttcgtaatt ctaacatagc tgccccctat ctataataac tatacttctt
    10801 ctcaactttt ttggaaataa ttgtcacaat cccaattaaa atcaagtaaa tggctcctgc
    10861 caagaacata ggaaccagac tagcatcgcg gttagcagct gttcgactag ccaagataag
    10921 gtctgaaatt ccgagagcat agaccaaaga agtatccttg accaaactca taacttcatt
    10981 aaagacacta ggaagaacga tcttggtcac ttggggcaag ataatatagc gcactctgtc
    11041 aaaagggcta aacttcaaga ccttggcagc ctcatactgt cctcttggaa tagtgtcaat
    11101 tcccccacgg aaaatttctg caaagtaagc tgcatagttg agaacaaagg caataatagc
    11161 tgcaggaagg cggtctaaac gaatcccaat acttgggagc acataataga taaaaatcag
    11221 ttgcaagagt aagggggttc ctcgcataac ccagatgtaa atgttaatca gataatggag
    11281 gggcttccaa tggacttgca aggcaaaggc aatcaaaacg cccaacggaa tcgaaaatag
    11341 caagaccagt gcaaagacct gtacagtcgt gctcgcacca ttcagtaaac tcggtaatat
    11401 ctcaaataaa taagacatac tgcacctcct aaaagtaatt gttcctatta tagcatgaat
    11461 aaacaagatt accaagtatt tttgtaaaaa gattctacca tatacaaata aaaaccgtag
    11521 ctatcaaaag agataaacta cagttctata tgtttaaaca ttcttacaat ctctcaaaca
    11581 gttcttgcat ttgcacatca tctggaacca gttttaagta agtgtgagca tggacttttg
    11641 cttcttcaaa atgtcccaat tcacgcaaga gatagatata gtgttccaga aattctggat
    11701 tgtccttcaa atctcctgtc aactcttgat aatgctcata agcagtatcc aaatcgtcca
    11761 tttcttgata agaacgagca atcatccact tggtcaaaag attttctggc tcctcactct
    11821 gcaagtctag aatatcctca taacgctcct gctccagata aatagtggct aaacgaagca
    11881 agatttcttc tgtatcctca gcgtcttctt ttgcagtaag gagataattt tctgcaccac
    11941 tagcatcatg caattcataa gaaaattgtg aagcagctag caagaggcga gtttcaaagg
    12001 gatttttctc taatccttgc ttagcgatat gcagggcttc ttgaacttga tgttccttat
    12061 gtaaagcctg actgtaccca tactcatagc cttcaaagtc aggagaaatg gtatcaagct
    12121 gcttaaagta gagggtggct ttttgatatt cttcttgatc aaaataaaga ctggccaact
    12181 caaaagctgt taagtcatcg tattctaact ccagggcttt ttctaaaaac tcagtagccg
    12241 tttcaaattt ccctaactga gcataggcaa agccaattcg ttgataggtg gaaatgcccg
    12301 tttgctcata aatcgagcga ttatctaact gggcataggc ttgaatagcc gcttggtaat
    12361 tttccaactc actatccaac tctgccaaac ccaatatcaa gagagaatcc tctgagtagg
    12421 tcaaggcctc caataatttc tcacgtgcca catctgtcaa accttccagc tggtaaaggt
    12481 ctgccttcaa aaccaaagac gagacatacc agtcactgtc agcttggatt tcctcaagat
    12541 aggtaaaggc ttcttctatt tgaccatcct cgctagcaat tgcagctaga ttaagatgaa
    12601 cctctggaaa atcctctaca attttcaggt aaatttcctt ggcctgagga tagaaaccaa
    12661 tcccttcaag ataagttgcc aactcataca gaagatcact tgaatcattt tctaaagctt
    12721 tggcgaaata atgctcagcc ttagttaaat cttgctcctc caaagcctgt aacatctgtt
    12781 gactattgtt cactcttgac ttcctcaccc tctaattcat atagaccact gactacctta
    12841 taccattcga aaatggctga aatgacaacc ttagcagagg cataaactgg aataccaagt
    12901 aaaactcccc agataccaaa catagatcct gaagttaaca aaacaaagag aacattaata
    12961 gggtggatgt ttaattgact tcccaaaatc aatggagaga caaaacggcc ttcaatagtt
    13021 tgttctacaa taaagacaat cactactttc aaaagcatga ctggaccagc aatcaaaccc
    13081 aatactaggg caggaagcat ggctagaaag ctaccaagat aagggaccag atttaaaata
    13141 ccagcagtaa cccccagcgt aaccgcatag cgtagaccaa taatcttgaa gaagatgata
    13201 aacattactg ctacaataat agccactgtc acttgccctc gaacatagtt ggacaactgt
    13261 tgattcacat ctgatagaac ttgtccaaca ggttccttca attttcttgg aatgaattgg
    13321 gtcaaatagt tacgcaagcc tttcccatca cgcaagagat aaaagagcat gaaaggaacg
    13381 ataatcaagg caacaatcac ttgagaagcc ccgctaataa aggcactcac ccagttgact
    13441 gcctgagatg aaaccttact tgccaaaact gtagcctggc tagaaaaatt ggtcaaaact
    13501 tgctctaatt gaggtctgaa atcatctggc agatgctggg ctaccaatcc attaacaatc
    13561 ctatctatat cttctaagta aacaggaacg tttcttgcaa aggtcaaaac ctgacgttgc
    13621 agatttggaa tggcgactgc caagccccaa atgataaaga gagcgatgat aacaaagaca
    13681 atagtgatag ctataacacg attaacctta tgcttctcca tccaatcaac aataggattc
    13741 aacaaataat ataacaaacc agacaaaatg actggcaaca tcacaactgc taaaaagtct
    13801 aaaacaggtg aaaatagaaa actaatctta cttaaaataa aaagattcaa tcccaataat
    13861 aaggttacta aaaataccgt aattgccttg ttatctaaaa accacttgaa aaaccaagat
    13921 aggctaaaat gtttctcttt ttgctccata aatacttcct ttctattgtt ctctcattat
    13981 accatttttg aaacaaaata actctttttt aaagtgctta catctaattg gatgtcttta
    14041 atttgcttgt ttttgtgata taatagtctt atctttacat agaggtatag taatgaaaga
    14101 aactgtttat tttggaactt atacacgtcg tacttctcaa gggatttaca aggcagactt
    14161 tgatacagaa actggtcagc tttcaaatct agaacttttt gcagctgagc caagtccaac
    14221 ctaccttgcc tttgaccagc accaacattt atacactgtt ggtagccaag acgataaggg
    14281 gggaattgca gcctatcaaa ctgacgggac tgtgttaaat catgttgttg aagaaggagc
    14341 tccccactgt tatgttgctg tcgatgaaaa gcgtgatttg gtttacgcag ccaactatca
    14401 caagggacaa gtccttgttt ataaacgcca ggaagatggt agtcttctac ttagtgatat
    14461 ggatcaacac agtggccaag gtccacatga aaatcaagct tccccccatg ttcactatac
    14521 agatttaaca cctgaccact atctagtgac ctgcgacttg ggaactgacc aagtcatcac
    14581 ctatgatctc gatcaagaag gaaaattatc taagctctat acctatcaca gcaagccagg
    14641 agcaggctca cgccatatca ttttccataa ccactataaa atcgcttatc tcatttgtga
    14701 actcaatagt actatcgaag ttttaatcta cgatggcgtt ggcgaatttg tacgtatgca
    14761 ggttatttca actttaccag aagcttacga aggctttaat ggaaccgctg ctattcatct
    14821 ctctaaagac ggtaaatacc tctacgcttc taaccgtggc catgattcta tcgcagtata
    14881 taccatcctt gcggacggta gcttagagtt attagaaatc gttccaacgc atggtcagac
    14941 tccacgtgat tttgatttga cacccgacca aaaatttctc attgttgtcc atcaagactc
    15001 tgacaatgca actgtcttta aacgtaattg tgacaatggt cgtctagcag aactctccaa
    15061 cgacttccat gttcccgaag cagtctgcat ccgttttgct ccttaaaaca ccataaaaaa
    15121 tgaacttggt attttcaagt tcattttttc ttatagtcta tttccgacat taatacggtt
    15181 aatggcacgt tgcaaagcaa tcttagcacg acgttcttgg tcaatcaaat gtttgtcttg
    15241 tgcttcttca attgcacgtt ctgcacgaag tttggcacgt tctgcacgac tgatatcgat
    15301 atcacgagca cgttctgcag agtcagcgac gattgtaatc atatcattgg caatttcaat
    15361 aacgccaccg tttactgcaa tccagttcac gtgatcttta tcatcgatac gttttacctt
    15421 tacttcatca actgctaaaa ccgcaatcat attttcatgt cgtggcaaga tccccatctc
    15481 accatccaga gttcgaaccg atacatagct ggcatggtga tcatagacga gaccatctgg
    15541 tgtcacgatc tggacagtta actgagccat aggtcacctc ttaaaatccc attttttcag
    15601 cttttgcaat cacatcttcg atagaaccta caccacggaa ggcatcttct ggcaagtggt
    15661 cgtatttacc atcaaggatt tccttaaagc cacgtacagt ttcagcaact ggaacataag
    15721 aacctggctg accagtaaat tgttccgcaa cgttgaagtt ttgtgacaag aagaactgga
    15781 tacgacgggc gcgagcaacc aaggtctttt cttcatcaga aagctcatcc ataccaagga
    15841 tagcaatgat atcttgcaat tcatggtaac gttgaaggac acgttttact tcagcagcaa
    15901 ctgcatagtg ctcttctcca acgatttcag gtgccaaggc acgtgagctt gaagcaagtg
    15961 ggtcaacggc tgggtagata cccaattgta ccaatttacg ttccaagttt gttgttgaat
    16021 ccaagtgagc gaaggctgtt gctggcgctg ggtcagtata gtcatccgct ggcacataga
    16081 tagcctggat agaggttaca gaacccttct tggttgatgt gatacgttct tgcaattgac
    16141 ccatttccgt agcaagtgtt ggttggtaac caacggctga tggcatacga cccaaaaggg
    16201 cagatacttc tgaaccagcc tgagtgaaac ggaagatatt atcgataaag agaagcacgt
    16261 cttggccttc cacatcacgg aagtattcag cgattgtcaa accagtaagg gcaacacgca
    16321 tacgtgctcc tggtggctca ttcatctgac caaagaccat ggctgttttc tcgataacgc
    16381 ctgattcttt catttcccag taaaggtcat tcccctcacg agtacgttcc ccaacaccag
    16441 taaatactga aataccaccg tgctcttggg caatgttgtg aatcaattct tggattaaga
    16501 cggttttacc aactccggca ccaccgaaaa gtccaacttt accaccttta aggtaagggg
    16561 caagaaggtc aataaccttg atccctgttt caaggatttc agaagaggta gacaactcat
    16621 caaaagttgg agctttttta tgaattggct gacgctctgc gtcttctgta aaaggagctt
    16681 ccaaatcaat ggtatctccc aaaacgttga agacacgtcc caaagtttct ttacctactg
    16741 gtacagagat tggacgacct gtgtccaata cttccattcc acgagtcaac ccatctgttg
    16801 attccatgga gatagtacga accataccat ctcctaactc caaggctact tcaaggacga
    16861 tttttgtttt tctttcgtca tttttgtaga cgacaagtgc attgttaatc tcaggaagtt
    16921 tttcccctgc tgcaaacaaa acgtctacaa cgggaccgat aacctgagca attttacctg
    16981 aactcatctc cttctcctat tctatataag atactgtcgg ttcctagctc aactaggtcc
    17041 taagttcatt ttcatacgag ctggactaga gcctattcta aggcactagc acctgctacg
    17101 atttctgtaa tttcttgtgt aatcgccgcc tgtctggcac ggttatactg aattgtcaaa
    17161 tcattgatga ctttcttagc attatctgtc gctgtttgca tggctgtcat acccgcagca
    17221 ttctcagctg tcttggcatc gataatggca ccgtaaatca tactttctgc aaactgaggc
    17281 aacaactgct ccagaatttc ttctcggctg gtttccaatt caaaagtcaa gctgtactct
    17341 tcatccgcct catttggatc caagtcaaca atcggaagca tttgttccac acgcatttga
    17401 ctggttagcg tattgacatg gtggttgtag caaacataaa gctcatcaaa gagttcattt
    17461 tggtacattt caacagtttt tgaaataatc ttacgaactt gatcaaagct aggttggtct
    17521 gccaagccac gtaattcata aagtggttga ataccgcgag ccttaaagaa atcagctccc
    17581 atcccaccga tacagatcat ttcaaaacct ttaccgtctg ggtggtattc ttctttcaac
    17641 tccataacag ctttcaaaat agaggaatta taacctccaa ccaaaccgcg gtctgaagtg
    17701 ataacgatat agcctgtctt cttcacagaa cggctaatca acatcggatt agttgaagca
    17761 ccagctccat taccatgaag gatatctgtc aaaagtttac gcactttctg agcgtaaact
    17821 tggaagttgc gagcagcttc ttcagagcga cctaacttag cagccgatac catttgcata
    17881 gcattagtga tttgactcgt attttttgtt gaggcgattt ttgttttaat atcatttaga
    17941 gacactgcca tctgacacct ctattcttat tggaagctag attgattgag aaactctgta
    18001 atcgcagcat ccaagactgc ttcttctggc aagtcttttg tatcacgaat ggtttccaaa
    18061 atctctggat gttgagcatc aaagaaggca tggaactctt cctcgaaacg aacaatatca
    18121 tctactggaa cagtatccaa gaaaccatgt gtcaaagcat aaagaatggt tacttgtttc
    18181 tcaacaggta atggtttgtg aacaggttgt ttcaagacct caacggtacg acgtccacgg
    18241 ttcaacttag cctgtgttgc tgcgtccaag tcagaaccaa acttagtaaa ggcttccaac
    18301 tcacggtatg aagcaaggtc gatacgaagt gtaccagcaa ccttcttcat ggctttgatt
    18361 tgtgcagaac cacctacacg agatacagat gaacccgcat cgatggctgg acgaatacct
    18421 gcattgaaga ggccatcgcc aaggaagatt tgtccatcag tgatagaaat cacgttggtt
    18481 gcgatatagg ctgagatatc tcctgcttgt gtctcgataa atggtagggc tgtaattgat
    18541 ccaccaccaa gttcatcaga aactttagct gagcgctcaa gcaaacggct gtggagatag
    18601 aaaacatccc ctgggaaggc ttcacgacct ggaggacgac gaagcaagag cgacagttca
    18661 cgataagcta ccgcttgttt tgatagatca tcgtatacaa tcaaaacatg cttaccttga
    18721 tacataaatt cttccgccat agcaacccca gcataaggag ctaggaagag caatggagat
    18781 ggttgtgaag cagaggctgt cacaacgatt gtgtagtcca aggcaccgta ctgacgaagt
    18841 gtttctactt gcgtacgaac tgttgattct ttttgtccaa tcgcgacgta gatacagatc
    18901 atatcttgat ctttttggtt caagattgta tcaatcgcaa tggttgtttt ccctgtctga
    18961 cggtcaccga taatcaactc acgttgacca cgaccaatcg gtacaagggc gtcaatagct
    19021 ttcaaaccag tttgcaatgg ttctgaaaca gacttacgtt gcataacacc aggagctggt
    19081 gcttctactg gacgagtttt atcagtgtgg atttctccaa gaccgtcaac tggacgacca
    19141 agcggatcca caacacgacc aatcagactt tcacctacag ggacttccat gattttccct
    19201 gtacggcgga ttgtatcgcc ttcacggata tctgtaaagt cacctaggat gataatacca
    19261 acgtctgttg actccaagtt ttgagccata ccataagagc cgttttcaaa attcaacaac
    19321 tctccactca tgacattttc aaggccgtga gcacgcgcga taccgtcccc gatataggtt
    19381 acaacacctg tttcagtcac atcaaaattg ggtttgaaat tttcaatttg ttgcttaatt
    19441 aaagcgctga tttcttgtgc gttaattgcc aaaagaacac cactttctat ttcaaatttt
    19501 ctttaacaac tttaagttgt tgtttaatac tcacatcaat tgtcttgtga ttggcaaaaa
    19561 tgacaaaacc accaatgaga ctttcatcga tttgttcttt tacactcctt actttcagag
    19621 acattttttt ctcaatcaaa gggagcaaac gagtcttctg ttcatcagtt agaggatgag
    19681 cagacgtaat cgtcacttca aatcgatttg tttctttttc aagtcggttc aagcaatcta
    19741 caagcacatc ataaaaaaga tttgctctgt gattgtaggc cagaacctgg ataaagtttt
    19801 gtaataaagg cgacacagaa tcttggaaaa aagcaattgt tttttcctta tccgactcgt
    19861 ctactgccac ttgttttaaa aaagaaggca gacctgtttt ttcaacaact tgcttgattt
    19921 gagtcaagtc tgaaaagata cggtcttctt ctcctttttc aagtaccaat tggacaaaag
    19981 gcatgctgta tttttcaatt acctttactg ttttcttgtc cattaagctt ctcctagctg
    20041 atcgatatac tgatcaatga gtgctttatg ggcatgactg tcaaggtttt gtgagatgat
    20101 tttaccagct aagctgatgg tcaaatctgc gacctcaccc ttaacactct gtaaagcttc
    20161 tactttattt tgagcaattt cttgattggc tttttctttt aagtgtcctg cttctagttt
    20221 agcatctgct aagatattag ccttactttg ctcagctgtt tcctttgcat tttcaatgat
    20281 tgtcttagct tctttacggc taccagccaa ttcatcttcg cgtttttgag ccaatacttc
    20341 tgctttttga cgggcttctt cagctctgtc aatatctgaa gcaatttttt cagctctttc
    20401 ttcgaaaatg cctgtaatat tagaccatgc aaatttttta atcaagacta gcaaaagaat
    20461 aaaagagcca gtgattaaaa taaaattacc aattaattca cctactgtta cgtgcatcag
    20521 ttactccttt ctattcctct tcaatattaa tcttattccc taaatacaca gatgtcaaaa
    20581 gagtaaaaac ataagcttgg atgcaggaaa taaagacaga aaatgcagtc caagccaaat
    20641 tagctccaaa ggctactgga taccaataaa tagcttggtg ggaaagaaga agtaacaaac
    20701 tcgtcatgac ctctcctgca aagatattcc caaaaatccg caaagccaaa gataagaagt
    20761 ttgtaaattc ttccaagata ttcatcggta tgacaaaaac aggactcata aaagatttta
    20821 tacttttttt aaatccacga cgacgaacgc tttctatatg tgtcaacaaa atgacaagaa
    20881 aagataaggt taagtcatac tgtaaattag cggttggcga actccaccag ttagtcccat
    20941 cgatcgtttg aagctttgtc attaagccaa ggttattggc aatcaccatg aaaaggaata
    21001 aacaaaggaa aaagagtgag taatctttca tgtagcgcga accaatgtta ggttctgtaa
    21061 atccaataac aaagtcatag acatactcaa gtacattttg ctttcctttg ggtttcaagg
    21121 tcatattgcg gcttgcccaa taaataaaga caaaaataac tcccacaatc aacaaagtca
    21181 tggctaacat agtcagattg aagataacag gaccaataga gatgattgga ttaatacttt
    21241 cttccatcta aaatcctccc ttttcttctc gttccatgta tttatttgat aataaatgag
    21301 aagacaagag ttacaaagaa agttccttca ataaaggcaa cacctaaaaa catcaaacta
    21361 cgaaactcag aaagcatatc tggttggcgt gctactgatt taaacagtcc attcatcaat
    21421 aaaccttcac cgacagatac gcccatacag gcaatacata agcctaaaaa tgttaaattc
    21481 ataacaaatt ctcctttaaa ataaaattta cttacttagt gtagtcctaa aatttaaatt
    21541 tgtcaacttt taaccgctat tggaagcgtt taataaaaat tatttccatt t
//
LOCUS       DAVHIZ010000030        20782 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.032, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000030 DAVHIZ010000000
VERSION     DAVHIZ010000030.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20782)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20782)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20782
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.032"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(309..647)
                     /locus_tag="VVO18_001272"
     CDS             complement(309..647)
                     /locus_tag="VVO18_001272"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000915343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase C39"
                     /protein_id="HEU5586431.1"
                     /translation="MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTD
                     MYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIK
                     EKIKGTRITK"
     gene            1113..1976
                     /locus_tag="VVO18_001273"
     CDS             1113..1976
                     /locus_tag="VVO18_001273"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001268160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5586432.1"
                     /translation="MRYDFGKVYKEIRESKGLTQEEVCGGVLSRTSLSKIESGKTTPK
                     YENMEFLLRQINMSFEEFEYICQLYQPSQRTEIMQTYLNMRSIIGTSDLVNLFQKCQD
                     YLKTHHDLPIEEIRDMLEVVIYIRQHGAGELSDHAEQVVKKLWRKIEKQDTWYESDLK
                     ILNTILFSFPIEYLHLITGKILQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMC
                     KQICYTLLEDAKNKKSYDRLAICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKK
                     EVEIYYQAKER"
     gene            complement(2376..2744)
                     /locus_tag="VVO18_001274"
     CDS             complement(2376..2744)
                     /locus_tag="VVO18_001274"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SP_0115 family bacteriocin-like peptide"
                     /protein_id="HEU5586433.1"
                     /translation="MELVLPNNYVALEQEEMMYLDGGGVGCNWWNSRGSFATVLDVDL
                     AIYSGGATIYSAYAIKKAISANRGAITRTLRSLIIKHVGSAAGHLVNTALTVTGFSLG
                     GAIAYGVDWADGSLDGYIFA"
     gene            3503..3823
                     /locus_tag="VVO18_001275"
     CDS             3503..3823
                     /locus_tag="VVO18_001275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861316.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU5586434.1"
                     /translation="MQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTL
                     LEDAKNKKSYDRLAICYVRIGICRDNAKLIQKGFSLLELTEETSMLSHLKKEVETHYQ
                     PKKL"
     gene            complement(4113..4583)
                     /locus_tag="VVO18_001276"
     CDS             complement(4113..4583)
                     /locus_tag="VVO18_001276"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012386596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate synthase"
                     /protein_id="HEU5586435.1"
                     /translation="MRMPLKRPLKNRKKEKNMSKEKVILAYSGGLDTSVAITWLKKDY
                     DVVAVCMDVGEGKDLDFIHDKALKVGAVESYVIDVKDEFATDYVLVALQSHAYYEQKY
                     PLVSALSRPLISKKLVEIAHQTGATTIAHGCTGKGNDQVEYQIAVAKKANEAKK"
     gene            complement(4549..5355)
                     /locus_tag="VVO18_001277"
     CDS             complement(4549..5355)
                     /locus_tag="VVO18_001277"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="HEU5586436.1"
                     /translation="MNKMKKVLMTMFGLVMLPLLFACSNNQSAGIEAIKSKGKLVVAL
                     NPDFAPFEYQKVVDGKNQIVGSDIELAKAIATELGVELELSPMSFDNVLASVQSGKAD
                     LAISGVSKTDERSKVFDFSTPYYTAKNKLIVKKSDLATYQSVNDLAQKKVGAQKGSIQ
                     ETMAKDLLQNSSLVSLPKNGNLITDLKSGQVDAVIFEEPVAKGFVENNPDLAIADLNF
                     EKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKLIEDAFKASIEK"
     gene            complement(5562..6203)
                     /locus_tag="VVO18_001278"
     CDS             complement(5562..6203)
                     /locus_tag="VVO18_001278"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586437.1"
                     /translation="MIELKNITKTIGGKVILDNLSLRIDQGDLVAIVGKSGSGKSTLL
                     NLLGLIDGDYSGRYEIFGQTNLAVNSAKSQTIIREHISYLFQNFALIDDETVEYNLML
                     ALKYVKLPKKDKLKKVEEILERVGLSATLHQRVSELSGGEQQRIAVARAILKPSQLIL
                     ADEPTGSLDPENRDLVLKFLLEMNREGKTVIIVTHDAYVAQQCHRVIELGEGK"
     gene            complement(6200..8308)
                     /locus_tag="VVO18_001279"
     CDS             complement(6200..8308)
                     /locus_tag="VVO18_001279"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU5586438.1"
                     /translation="MKKISHLCMLLLLLCTTFFVFNVNYTREVVRIQEMGKTVDSLDL
                     YLKDINEPAASVLRFFEDVSKEYKVSIIKTDSGDEVVKSGVFDKDTFPYQEFGISSLD
                     FTTDGEGVYSNKEISNKLGTIPTFLKAKPIQLMTFQTYIKDTSRSLNGRYTITSTQEM
                     DKDRIVQKWSDFFKIDQATLLEPTYKSAVEVINRDLLLSAIVFVLAILLLVLVTVYQP
                     MMEMKRVGVQKLLGFQDRAVLADVVKGNLYLLLGGALVINLGVFFLLDYKPKDLFPML
                     WLSHFLLLQLYLFISWLTYLLIQKMTISSLLKGFSSFKFGLLFNYLMKIGTTILLTVL
                     LVGVGKSLEQENKELDYQKQWISQGNYLTLETFQLNDNLWQEQLAGSGKALDYFYRFY
                     QDLVEKTQAGYVQSSSLPVKNFVQSEQIQQYQLTDTVDVYYANRNFLKSKGFKLPDTG
                     IKKVILMPASTKGEEDKNQLLGKLIAFHSMKYEEQQKRTIEEMDVEIAYYEGDWSFFP
                     YSDKRKENLSNPIISLVNDSDMMWDEKASLSTTGLNNPIKIENTVQHQKEITELVEKL
                     SDGNYLKFSSIQAIQQEKVDSYRDAVRNFNLLFALFGLLSMMISYFLLVTTFLLKRRD
                     IITKKFMGWKLVDRYRPLLVLLLLGYSFPLLVLIFFAHAFLPLLLFAGFTCLDILFVL
                     GLASRMEKRSLVELLKGGIL"
     gene            complement(8363..8656)
                     /locus_tag="VVO18_001280"
     CDS             complement(8363..8656)
                     /locus_tag="VVO18_001280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEU5586439.1"
                     /translation="MIGEINHEKIGVASLMVCSILASTSVLAVWVDGGQWNYGVGWSG
                     NFGYSDYLHSTRSHTATVKDGNKFSKDRAEAEAWARASIFKFPPTGMEYFYGF"
     gene            9063..9383
                     /locus_tag="VVO18_001281"
     CDS             9063..9383
                     /locus_tag="VVO18_001281"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="HEU5586440.1"
                     /translation="MQRLEVYKNYQHLYDLRIAILLNLSTLYLYNQDKNMCKQICYTL
                     LEDAKNKKSYDRLVICYVRIGICTDDSKLIQKGFSLLELTEETSMLSHLKKEVEIYYQ
                     AKER"
     gene            complement(9435..10022)
                     /locus_tag="VVO18_001282"
     CDS             complement(9435..10022)
                     /locus_tag="VVO18_001282"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843467.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysM peptidoglycan-binding domain-containing
                     protein"
                     /protein_id="HEU5586441.1"
                     /translation="MKSITKKIKATLAGVAALFAVFAPSFVSAQESSTYTVKEGDTLS
                     EIAETHNTTVEKLAENNHIDNIHLIYVGQELVIDGPVAPVATPAPATYAAPAAQDETV
                     SAPVAETPVVSETVVSTVSGSEAEAKEWIAQKESGGSYTATNGRYIGRYQLTDSYLNG
                     DYSAENQERVADAYVAGRYGSWTAAKNFWLNNGWY"
     gene            10264..10935
                     /gene="sdaAB"
                     /locus_tag="VVO18_001283"
     CDS             10264..10935
                     /gene="sdaAB"
                     /locus_tag="VVO18_001283"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606087.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent
                     subunit beta"
                     /protein_id="HEU5586442.1"
                     /translation="MKSLRFQSVFDIIGPVMIGPSSSHTAGAVRIGKIVSSIFDDTPT
                     EVEFQLFNSFAKTYRGHGTDLALVAGILGMDTDDPEIPNSLEIAHKRGIKIVWTIQKD
                     SNAPHPNTTKITVKNAHKTISVTGISIGGGNIQVTELNGFAVSLNMNTPTIIIVHQDI
                     PGMIALVTEALSRYGINIAQMNVTREKAGEKAIMIIEVDSRNCDEAIEEIRKIPHLHN
                     VNFFK"
     gene            10944..11816
                     /gene="sdaAA"
                     /locus_tag="VVO18_001284"
     CDS             10944..11816
                     /gene="sdaAA"
                     /locus_tag="VVO18_001284"
                     /EC_number="4.3.1.17"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000500050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-serine ammonia-lyase, iron-sulfur-dependent,
                     subunit alpha"
                     /protein_id="HEU5586443.1"
                     /translation="MFYSIKELVEQADLDFQGNVAELMITTEFELTGREREEVFLLME
                     RNLEVMKASVQLGLNENKSRSGLTGGDAAKLDHYIENGKTLSDYTILSAARNAIAVNE
                     HNAKMGLVCATPTAGSAGCLPSVLTAAIEKLDLSHEQQLDFLFAAGAFGLVIANNASI
                     SGAEGGCQAEVGSASAMSAAALTLAAGGTPYQASQAIAFVIKNMLGLICDPVAGLVEV
                     PCVKRNAMGASFAFIAADMALAGIESKIPVDEVIDAMYQVGASMPTAFRETAEGGLAT
                     TPTGRRLQKEIFGE"
     gene            11838..12470
                     /locus_tag="VVO18_001285"
     CDS             11838..12470
                     /locus_tag="VVO18_001285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200889.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU5586444.1"
                     /translation="MTSITAIFFDLDGTLVDSSIGIHNAFTYTFKELGVPSPDAKTIR
                     GFMGPPLESSFATCLSKDQISEAVQIYRSYYKAKGIYEAQLFPQIVELLQELSKNYPL
                     YITTTKNTPTAQDMTKNLGIHHFFDGIYGYSPEAPHKADVIHQALQIHQLAPEQAIII
                     GDTKFDMLGARETGIQKLAITWGFGEQADLLNYQPDYIAHKPLEVLEYFQ"
     gene            12520..12924
                     /locus_tag="VVO18_001286"
     CDS             12520..12924
                     /locus_tag="VVO18_001286"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586445.1"
                     /translation="MKIKEQTRKVTAGCSKHCFKVVDGTDEVSSKHCFEVADRTDEVS
                     SKHCFEVADRTDEVSNHIYGKATLTWFEEIFEEYKSLHNKTHSTKVNKLDTMRFSFLF
                     NVGCLISKGDNSLLQLISTESAELSNLLIDGF"
     gene            complement(12820..14670)
                     /locus_tag="VVO18_001287"
     CDS             complement(12820..14670)
                     /locus_tag="VVO18_001287"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /protein_id="HEU5586446.1"
                     /translation="MNKKLTDYVIDLVEILNKQQKQVFWGIFDIFSMVVSIIVSYILF
                     YGLINPAPVDYIIYTSLAFLFYQLMIGFWGLNASISRYSKITDFMKIFFGVTASSVLS
                     YSICYAFLPLFSIRFIILFILLSTFLILLPRITWQLIYSRRKKGSGDGEHRRTFLIGA
                     GDGGALFMDSYQHPTSELELVGILDKDSKKKGQKLGGIPVLGSYDNLPELAKRHQIER
                     VIVAIPSLDPSEYERILQMCNKLGVKCYKMPKVETVVQGLHQAGTGFQKIDIMDLLGR
                     QEIRLDESRLGAELTGKTILVTGAGGSIGSEICRQVSRFNPERIVLLGHGENSIYLVY
                     HELIRKFQGIDYVPVIADIQDYDRLLQVFEQYKPAIVYHAAAHKHVPMMERNPKEAFK
                     NNIRGTYNVAKAVDEAKVSKMVMISTDKAVNPPNVMGATKRVAELIVTGFNQRSQSTY
                     CAVRFGNVLGSRGSVIPVFERQIAEGGPVTVTDFRMTRYFMTIPEASRLVIHAGAYAK
                     DGEVFILDMGKPVKIYDLAKKMVLLSGHTESEIPIVEVGIRPGEKLYEELLVSTELVD
                     NQVMDKIFVGKVNVMPLESINQKIGEFRTLSGDELKQAIIAFANQTTHIE"
     gene            complement(14712..15869)
                     /locus_tag="VVO18_001288"
     CDS             complement(14712..15869)
                     /locus_tag="VVO18_001288"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000096189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5586447.1"
                     /translation="MSSKVSGFQDKNGKVLKIMIEWWKEKFRRVVVTQNVESLLVSIV
                     ISAYNEEKYLPGLIEDLKNQTYPKENIEILFINAMSTDGTTAIIQQFIKEDTEFNSIR
                     LYNNPKKNQASGFNLGVKHSVGDLILKIDAHSKVTETFVMNNVAIIQQGEFVCGGPRP
                     TIVEGKGKWAETLHLVEENMFGSSIANYRNSSEDRYVSSIFHGMYKREVFQKVGLVNE
                     QLGRTEDNDIHYRIREYGYKIRYSPSILSYQYIRPTFKKMLHQKYLNGLWIGLTSHVQ
                     FKCLSLFHYVPCLFVLSLVFSLALLPITFVFITLLLGAYFLLLSLLTLLTLLKHKNGF
                     LIVMPFLLFSIHFAYGFGTIVGLIRGFKWKKEYKRTIIYLDKISQINKNML"
     gene            15927..17093
                     /locus_tag="VVO18_001289"
     CDS             15927..17093
                     /locus_tag="VVO18_001289"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CynX/NimT family MFS transporter"
                     /protein_id="HEU5586448.1"
                     /translation="MKKQSLFFVPGIILIGVSLRTPFTVLPIILGNISQGLEVEVSSL
                     GVLTSLPLLMFTLFSPFSTQLAQKIGLEHLFTYSLFFLTIGSLIRLINLPLLYLGTLM
                     VGASVAVINVLLPSLIQANQPKKIGFLTTLYVTSMGIATALASYLAVPITQASSWKGL
                     ILLLTLLCLATFLVWLPNHRYNHRLAPQTKQKSQIKVMRNKQVWAIIIFSGFQSLIFY
                     TVMTWLPTMSIHAGLSSHEAGLLTSILSLISIPFSMTIPSLTTSLSTRNRQLMLTLVS
                     LAGVVGISMLFFPINNFIYWLAIHLLIGTATSALFPYLMVNFSLKTSAPEKTAQLSGL
                     SQTGGYILAAFGPTLFGYSFDLFHSWVPSVAALLLIDILMTVALFTVDRADKIL"
     gene            17232..17558
                     /locus_tag="VVO18_001290"
     CDS             17232..17558
                     /locus_tag="VVO18_001290"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="HEU5586449.1"
                     /translation="MYFPTSSALIEFLILAVLEKGDSYGYEISQTIKLIANIKESTLY
                     PILKKLEGNSFLTTYSREFQGRMRKYYSLTNGGIEQLLTLKDEWALYTDTINGIIEGS
                     IRHDKN"
     gene            17545..18138
                     /locus_tag="VVO18_001291"
     CDS             17545..18138
                     /locus_tag="VVO18_001291"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000198695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1700 domain-containing protein"
                     /protein_id="HEU5586450.1"
                     /translation="MTRTEYLTQLELYLKKLPEADQIEAMDYFRELFDDAGVEGEEEL
                     IASLGTPKEAAHEVLSNLLDKKINEAPAQKNNRQILHVALLALLAAPIGIPLGIAILV
                     SLFAILVAALTVILAFFAVSILGIIGGFLFLVESFTVLAQAKSAFILIFGSGLLAIGA
                     SSLVLLGISYVARFFGLLIVRLVQFVLKKGKRGDQHA"
     gene            18131..19042
                     /locus_tag="VVO18_001292"
     CDS             18131..19042
                     /locus_tag="VVO18_001292"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001233690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4097 family beta strand repeat protein"
                     /protein_id="HEU5586451.1"
                     /translation="MRKLTKGFLIFGVVTTVIGFILLFVGIQSDGIKSLLAMSKEPVY
                     DSRMEELTFGKEVENLEITLHQHALTITDSFDDQIHISYHPSLSAHHDLITNQNDRTL
                     SLTDKKLSESPFISSGIDGILHIVSSSSNRFNDVIIGLPKGRTLKGINISANRGQTTI
                     INASLENATLNTNGYILRIEGSRIKNSKLTTPNIVNIFDTDLTDSQLESTEHHFHAEN
                     IQVHGKVELTAKDYLRIILDQKESQRINWDVSSNYGSIFQFTREEPESRGTELSNPYK
                     TEKTDVKDQLIARSDDDIELISTPSRR"
     gene            19105..20169
                     /locus_tag="VVO18_001293"
     CDS             19105..20169
                     /locus_tag="VVO18_001293"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000808437.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586452.1"
                     /translation="MKQEWFESNDFVKTTSKNKPEEQAQEVADKAEERIADLDTPIEK
                     NTQVEEEVSQAEVELESQQEEKMETPEDSEARTEIEEKKASNSTEEEPDLSKETEKVT
                     IAEESQEALPQQKATTKEPLLISKSLESPYIPDQAPKSRDKWKEQVLDFWSWLVEALK
                     SPTSKLETSSTHSYTAFLLLILFSASSFFFSIYHIKHAYYGHIATINSHFPEQLAPLT
                     LFSIISILVATTLFFFSFLLGSFVVRRFIYQEKDWTLEKILQQYSQLLAIPIFLTAIA
                     SFFAFFDSLRFSALLCVISIGIILLASLHIITRPSQASEADSFYQLFLSVLVNGVIIL
                     LFFVAEVALIGNYLRILAFL"
     gene            complement(20406..20603)
                     /locus_tag="VVO18_001294"
     CDS             complement(20406..20603)
                     /locus_tag="VVO18_001294"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001257240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide ABC transporter ATP-binding protein"
                     /protein_id="HEU5586453.1"
                     /translation="MRSLSQEKDIYSFDEPTGNLDRNSTELFLNEVEKLVNEEKIVIV
                     VTHDKDVIARASKVINMDEFH"
BASE COUNT         6456 a         4546 c         3477 g         6303 t
ORIGIN      
        1 ctccttttca ttaccttact tgccttaaag attctgttta atagaacctt tatcgtagta
       61 tctacacaaa tttttatcaa aaagataaga gccaatacac ctgctgctgc accaataagc
      121 caacctccaa ggcctccaac cttaatatag tttattagtt tttttgttaa aactgcagct
      181 ccagtcaatg ctataaaagt tcctggactc atagctaaag ctgcgcaaat tccttgacaa
      241 gcactcttgc ttaaataagc ccccccccat caagatacat catctcctct tgctcaagag
      301 caacataatt atttggtaat acgagttccc tttattttct cctttatact atgtaatacc
      361 acaaaatgat tttgacctaa atcattctta acttgaagaa tcgcaggaaa tgttaatttt
      421 ggagtcaaat cttccagtgc tactcgaaca gcttttactg taaaattcaa cttattcaga
      481 cctgaaacaa taccactgac agtcgttcca tacatgtctg taccaataat ttcccgaatc
      541 ttcatgattg atagttcctt tttgtaagat aaaagaactg ttgaaacaac tgccgcagca
      601 caatctgact gatcatgttg catcgtacaa ggatattttt ttaacataga aatactcaat
      661 tctttagaat taatctaact tttctttgat gtcacccaaa cctcaatcac tgcccagtag
      721 ttcttgaatc agtttagttt caatcgtatc attctttgtt cttgatatct ttccaagcat
      781 tgtagtacag cagatttttg tccaaggact aagcctcctt taacaactca agctccctta
      841 cattatatcg accagcccca tggaaagatt atggccagac taatcaatga tataatacat
      901 actagaatac aaaatatttt tttattcata ctttttctcc tatctttatt ttctacctac
      961 atcatacctc ttattaagct cattttaaaa ttacgttaac ttttttcaca aatttatttc
     1021 gactttcttt tttacttttt acattgctat gatacaatat ttttaacaag attttattat
     1081 ttgttaactt ttttcacaga aaggagaaaa tcatgcgtta tgatttcgga aaggtctata
     1141 aagaaatacg tgagtcaaag gggctgaccc aagaagaggt ctgtgggggt gttctctcaa
     1201 gaaccagctt atcaaaaatc gaaagtggca agacaacccc aaaatatgaa aatatggaat
     1261 ttcttctccg tcaaatcaat atgagttttg aagagtttga atatatctgt caactttatc
     1321 aaccaagtca acgcacagag attatgcaaa cctatctcaa tatgcgttct attatcggga
     1381 ccagcgatct tgtcaattta tttcaaaaat gccaagacta cctcaagacc caccacgatc
     1441 tccctataga agaaatcaga gatatgcttg aagttgtcat ttatatccgt caacacgggg
     1501 caggggaact atcagatcac gcagaacagg ttgtcaaaaa actttggaga aaaattgaaa
     1561 aacaagatac atggtatgag agtgatctaa aaatcctcaa taccattctt ttcagttttc
     1621 ccattgaata cctccatctc atcactggaa aaatattgca acgcctagaa gtctataaaa
     1681 actatcaaca tttatatgac ttgcgaatag caatcctgct caacctttcc acactctatc
     1741 tatacaatca agataaaaac atgtgtaagc aaatctgcta cactttactg gaggacgcca
     1801 agaataagaa aagctacgat aggctggcta tctgctatgt ccgcattggg atttgtacag
     1861 acgattctaa acttatccaa aaagggttct cccttctgga gctgaccgag gaaacttcta
     1921 tgctgtctca tctcaaaaaa gaagtagaga tctattacca agcgaaggaa agataaaaaa
     1981 gccgagggag ctcctcgacc ttttcataga atcgccgaac gatttaacga gaaagtatga
     2041 cttttacgtt tatcccaact caattatgac atttttttca aaagtcaata tatctcactt
     2101 tttcaacgac aagaaagagg ctgataatct accaacctct tgtttttaaa tacatttcaa
     2161 gtccaaacta ttctttatag aaaaaagtcc tataaattcg agcaatagtt aaaatacaaa
     2221 caaatataat tcccaaaata gataacacta ttttcacaaa attcatttca gaacctatta
     2281 tatatacgtg aaaaaaaggg gctattccta cacatatata caataaataa cttacaaagt
     2341 ttatttcacc aattcctgca aaaaaatgtt tcattttaag caaaaatata accatctaag
     2401 ctaccgtcag cccaatcaac cccatatgcg attgctccac ctagtgaaaa tccagtaaca
     2461 gttagtgcag tattgactaa atggccagct gcactaccta catgtttaat tattaaacta
     2521 cgtaatgttc tcgtaatagc ccctctatta gctgagatag ctttttttat cgcataagca
     2581 gaataaattg ttgcaccacc actatagatg gccaaatcta catccagaac tgttgcaaaa
     2641 ctacctctac tattccacca gttacaacca acaccacccc catcaaggta catcatctct
     2701 tcttgctcaa gagcaacata attatttggt aatacgagtt ccatttattt tctccttttt
     2761 ttattaagca tggttaggat ggtttcctaa caagtgatcg caggctttgt ttagttacct
     2821 aaattagact tccttccttt atcttatttt aaatatttaa aaccagttac tgcttgaagc
     2881 ttaacagttt acttaattca aataacagct aatcactgat tccctgattt tatcaaatat
     2941 actaataaca acaattgtga tacgatcatc attataagaa caacatttaa cgaatcaaag
     3001 tttttccgag ataataataa agcaacagca agcagtatta ttactaaaga ttgaataact
     3061 actattactc ttaacatttt atcctccact aacaactcaa gctcccttac attatatcga
     3121 ccagccccat ggaaagatta tagctagact aatcaatgat ataatacata ctagaataca
     3181 aaatattttt ttattcatac tttttctcct atctttattt tctacctaca tagtacctct
     3241 tattaagctc atttcaaaat tacgttaact tttttcacga aaaggagaaa attatgcgtt
     3301 atgattatgg atagcgcttt caaattttta aactcctatc ccatcctttt atctatataa
     3361 taagtgaaaa tataataact gtcaagtaac tgaagtgaat tttataaaaa aattacaagc
     3421 caaatttgta aagtttacac taagccgcta gggcaatcgt ctatcagaat gtccgtttat
     3481 ttgtcaataa tccgagaaaa tcttgcaacg cttagaagtc tataaaaact atcaacattt
     3541 atatgacttg cgaatagcaa tcctgctcaa cctttccaca ctctatctat acaatcaaga
     3601 taaaaacatg tgtaagcaaa tctgctacac tttactggag gacgccaaga ataagaaaag
     3661 ctacgatagg cttgctatct gctatgttcg tattgggatt tgtagggata atgctaaact
     3721 tatccaaaaa ggtttctcac tcctagagct gaccgaggaa acttctatgc tgtctcatct
     3781 caaaaaagaa gtagagaccc attatcaacc aaagaaatta taaaaaaagt cgagggattt
     3841 cctcgactct ttacatatta tttgttcgtt agttcttaat accagccatt gttaaaccag
     3901 aagtttttag ctctgccaag ccacatagtg tgtttactac tatgtgtcca tgtcaccatg
     3961 aatcgccgaa cgatttaacg agaaagtatg acttttacgt ttatcccaac tcaattatga
     4021 catttttttc aaaagtcaat atatctcact ttttcaacga caagaaagag gctgccaatt
     4081 gaccaacctc ttattctgaa cccatcactc catcactttt tagcttcatt cgctttctta
     4141 gcgactgcaa tctggtattc gacttggtca ttccccttac ctgtacaacc atgagcaatt
     4201 gtagtcgctc ctgtctgatg cgctatttca accaattttt tagaaataag agggcggctc
     4261 aaggcagata ccaaggggta cttttgttca tagtaggcat gtgactggag agctactagc
     4321 acataatctg tagcaaattc gtccttaaca tcaatgacat aagattcgac tgccccaacc
     4381 ttaagagcct tatcatggat gaaatctaag tctttccctt cacccacatc catacaaact
     4441 gcaacaacat catagtcttt cttcagccag gtaatagcaa ctgatgtgtc taaaccgcca
     4501 gaataggcca aaattacttt ttctttactc atgttctttt ccttctttct atttttcaat
     4561 ggacgcttta aaggcatcct caatgagttt gtctaattcc ccagactcct tcaacttttg
     4621 aatggtttta tcgactgcct ctttcaattc cttgctatct tttttcatgg ctaccgcata
     4681 ggaatcatct tgctcttttt caaaattgag gtctgcgatt gctaaatcag gattattttc
     4741 cacaaatccc ttggcaacgg gttcttcaaa aataacggca tccacttgcc ctgattttaa
     4801 atctgtgatt aaattcccat ttttaggcag agatacgagg gaagaatttt gtagcaaatc
     4861 tttcgccatc gtctcttgaa tcgaaccttt ctgcgctccg acctttttct gcgccaaatc
     4921 gttgacagac tgataagtgg ctaaatcaga ttttttgaca atgagtttat tttttgcagt
     4981 atagtaggga gttgaaaaat caaacacctt gctccgttca tctgtcttag aaacacctga
     5041 tatggcaagg tcagcttttc ctgattgaac gctagccagt acattgtcaa aactcatagg
     5101 agatagttcc aattcgacac ctagttctgt tgcgatagcc ttggctaatt cgatatctga
     5161 acccacaatc tgatttttcc catcaaccac tttttgatat tcaaatggag caaaatctgg
     5221 attgagggct acaaccaatt ttcctttgga cttgatggct tcaattccag ccgattgatt
     5281 gttactacaa gcaaatagta gggggagcat cactaaacca aacatcgtca tcaacacctt
     5341 cttcatctta ttcataataa agcctccttt atgtttattc ttttttattg tataaataat
     5401 actcctatac tcatcctttg tcaagcctaa attgaaaaaa ttttcaattt gaaacaaaaa
     5461 aaacctagaa atactacata aaatgtcatt cctaggcgta tttatgctat ttttctctgg
     5521 aaaacatgag tattcagcca gtcaaaagga gctgaatgaa ctcattttcc ctcgcccaat
     5581 tcaatgacac gatgacattg ttgggctaca taagcatcgt gggtcacaat aatgactgtt
     5641 ttcccttctc gattcatctc taagagaaac ttcaagacca aatctctatt ttcaggatcc
     5701 agcgaacctg taggttcatc ggctaaaatc agctggctgg gttttaagat ggctctagca
     5761 actgcaattc gttgttgttc gcccccagac aactcggaga ccctttgatg caaagtagct
     5821 gacaaaccta ctctctctaa aatctcttcc acctttttga gcttgtcttt cttaggcaat
     5881 ttcacatatt tcagcgccag catgagattg tactcgaccg tttcatcatc aatcagggca
     5941 aaattttgaa acagataaga gatatgttca cggattattg tttgcgactt agcagaatta
     6001 accgctagat ttgtctgacc aaaaatctca taccgtccgc tataatcacc atctatcaaa
     6061 cccaataaat ttaacaaggt cgacttccca ctaccactct taccaacaat agctaccaaa
     6121 tccccctgat caatcctgag agataagtta tccaaaatca cttttccccc aatggttttg
     6181 gtaatatttt tcaactcaat cataagatgc cccctttcaa taactctact agacttcttt
     6241 tctccatcct agaagctaag cctagcacaa atagtatatc cagacatgta aaacctgcaa
     6301 acagtagaag tggtaagaac gcatgggcaa agaaaatcaa gactagaaga gggaaactat
     6361 agcccagcaa gagcagaacg aggagaggac ggtagcgatc gaccagtttc caccccataa
     6421 acttcttggt aatgatatcc ctgcgcttca ataagaaagt tgttactagt aagaagtagg
     6481 aaatcatcat gctaaggaga ccaaacaaag caaagagtag gttaaaattc cgaacagcat
     6541 ctcgataaga atccactttc tcttgttgaa tggcttgaat agatgaaaat tttaaataat
     6601 ttccatctga caatttctca actaactctg taatctcttt ttgatgttga accgtatttt
     6661 caattttaat cggattattt aagccagttg ttgacaggga ggctttctca tcccacatca
     6721 tatcagaatc attgaccaag ctaataattg gattggagag attttccttt cgcttatcac
     6781 tatatgggaa aaatgaccaa tctccttcat aataggcaat ctcgacatcc atctcctcta
     6841 tcgttcgttt ttgctgctct tcatacttca tcgaatgaaa ggcaattaac ttccccaaga
     6901 gctgattttt atcttcttca cctttcgtac ttgctggcat caaaataact tttttaatac
     6961 cggtatctgg tagcttgaat cccttgctct ttagaaaatt gcgattggca tagtaaacat
     7021 ccaccgtatc tgttaactga tattgctgaa tctgttctga ttggacaaaa ttttttacag
     7081 gaagactgct actctgcaca tagcccgcct gcgttttttc taccaaatcc tgataaaatc
     7141 gatagaaata atccaatgcc ttccctgagc ctgccaactg ctcttgccac aagttatcat
     7201 tgagttggaa agtttctaag gtcagataat ttccttggct gatccactgt ttctggtaat
     7261 ccaactcttt gttttcttgc tccaaacttt ttcctacccc aactagcaag actgtcagta
     7321 aaatggtagt tccaattttc atcaaataat taaagagtag accaaatttg aaagatgaaa
     7381 aacctttcag cagagagctg attgtcattt tttggattaa gaggtaagtc aaccaactga
     7441 taaagagata aagctgcaac agcaaaaaat gagacaacca cagcatagga aacaaatctt
     7501 ttggcttata atcaagcaag aaaaacacgc ctagattgat cacaagagcc ccacctagga
     7561 ggaggtaaag gttgcctttt acaacatcag ctaaaacagc cctatcttga aaaccaagta
     7621 atttttgtac cccaactcgt ttcatctcca tcatcggttg atacactgtc actaacacaa
     7681 gaagcaaaat agccaagaca aaaacaatgg cagataaaag caaatctcga tttatgactt
     7741 ccactgcact tttgtaggtc ggctctagca aggtagcctg gtctatcttg aaaaaatcgc
     7801 tccatttctg tacaatccta tccttgtcca tctcttgtgt agaagttatc gtatagcgac
     7861 catttaaact acgagatgta tccttgatat aggtttgaaa agtcataagc tgaataggtt
     7921 tggcttttag aaaggtcgga atcgtaccaa gtttattgga aatttcttta ttactataga
     7981 ctccttcacc atctgtggta aaatcaagag aagaaatccc aaactcttgg taggggaagg
     8041 tatctttatc aaaaacacca gacttgacca cctcatcacc actgtctgtt ttgatgatgg
     8101 agactttata ctcctttgat acatcctcaa aaaatcgaag aacagacgct gcaggttcgt
     8161 taatatcttt caaatacaaa tccaaagaat ctacagtctt tcccatttct tgaatccgaa
     8221 ccacttctcg tgtatagttt acattaaaaa caaaaaaagt ggtacacaga agcaggagta
     8281 acatacaaag atgactgatt tttttcatag agatacctcc cgtgaagaaa ctccctctcc
     8341 aaaaggggag ggagaatttt aattaaaatc catagaaata ttccattccc gttggtggga
     8401 atttgaagat tgaagcccga gcccatgcct cagcttctgc acgatcctta gagaatttat
     8461 ttccatcttt aacagttgct gtatgagagc gagtagaatg taaataatca gaataaccaa
     8521 aatttcctga ccatcctact ccatagttcc attgaccacc atcaacccat actgccaaaa
     8581 cacttgtaga agcaagtata ctacatacca ttaaagatgc aacaccaatt ttctcatgat
     8641 ttatttctcc tattatcgag agctattccg tagaaacagc tatagtaatt tgtcaacaag
     8701 tatcgtagtc cattggactc accttccttc tatctcattt catttttaaa caacgaactt
     8761 actcttaact agaagaatag ttctcttctg tatcaggtct ttgaacaacc agagtagtat
     8821 taatcacact ctaactatta ctcaagaatc agcccaataa acaatatgga tagcgctttc
     8881 aaatttttaa actcttatcc catcctttta tctatataat aagtgaaaat ataataactg
     8941 tcaagtaatc gaagtgaatt ttataaaaaa aattacaagc caaatttgca aagtttacaa
     9001 taagccgcta gggcaatcgt ctatcagaat gtccgtttat ttgtcaataa tccgagaaaa
     9061 tcttgcaacg cttagaagtc tataaaaact atcaacattt atatgacttg cgaatagcaa
     9121 tcctgctcaa cctttccaca ctctatctat acaatcaaga taaaaacatg tgtaagcaaa
     9181 tctgctacac tttactagag gacgccaaga ataagaaaag ctacgatagg ctggttatct
     9241 gctatgtccg tattgggatt tgtacagacg attctaaact tatccaaaaa gggttctccc
     9301 ttctggagct aaccgaggaa acttctatgc tgtctcatct caaaaaagaa gtagagatct
     9361 attaccaagc gaaggaaaga taaaaaagcc gagggatttc ctcgactctt tacatattat
     9421 ttgttcgtta gttcttaata ccagccattg ttaagccaga agtttttagc agcagtccat
     9481 gaaccgtaac gtcctgcaac gtaggcatct gctacacgtt cttggttttc agctgagtag
     9541 tcaccgttca ggtatgaatc tgttaattgg taacgtccga tataacgtcc atttgtagct
     9601 gtatagctac cacctgattc tttttgagcg atccattctt tggcttctgc ttcagatccg
     9661 cttacagttg aaacaactgt ttcacttact actggagttt ctgctactgg agctgaaaca
     9721 gtttcatctt gagcggctgg tgccgcataa gtagctggcg ctggtgttgc aacaggcgct
     9781 acagggccat cgataaccaa ctcttgacca acataaatca aatgaatgtt atcaatgtgg
     9841 ttgttttctg ccaatttttc aactgttgtg ttgtgagttt cagcgatttc tgaaagtgta
     9901 tcaccttctt taacagtgta agttgatgat tcttgagcag atacaaatga tggagcaaat
     9961 actgcaaaca aggcagctac tcctgcaaga gttgctttaa tctttttagt tattgatttc
    10021 atattcgaaa attctccttc tttctatagt tctatcatac cctttaaata ttaccgtttc
    10081 ttgacacttt tatgtagaaa tattacaaaa ttatttttta tttccctaaa taaggtgttt
    10141 tttgtcataa aagatactat ttttatgcta tttgaggtat tagaaaggtt ttcatccaca
    10201 attaaagcca agcccctcat tctttgatat aatagagata agaattttta taaggggaaa
    10261 ctgatgaaat cacttcgttt tcaatctgtc tttgatatca tcggaccagt tatgattggc
    10321 ccatctagta gccataccgc tggtgctgtt cgtattggga agattgtctc ttccattttt
    10381 gatgatactc cgacagaagt tgaattccaa ctttttaact catttgccaa gacctatcgt
    10441 ggtcacggaa cagacctagc ccttgttgca ggtattttgg gaatggatac agatgatcct
    10501 gaaattccaa atagtctgga aattgcccac aagcgtggta tcaagattgt ctggaccatt
    10561 cagaaagaca gcaatgcccc tcaccctaac accactaaaa ttactgttaa aaatgcccac
    10621 aagaccatca gcgtgactgg tatttctatc ggtggaggaa atattcaggt aaccgaactc
    10681 aatggttttg ccgtctctct caatatgaat acaccgacta tcatcatcgt tcatcaagat
    10741 attccaggta tgattgccct tgttacagag gcgctttccc gctatggtat caatatcgcc
    10801 cagatgaatg tcactcgtga aaaagctggt gaaaaagcca ttatgattat cgaagttgac
    10861 agtcgcaact gtgatgaggc tatcgaagaa attcgaaaaa tccctcatct ccacaatgtc
    10921 aatttcttta aataggagga agcatgtttt attctatcaa agaattggtc gagcaagcag
    10981 atctagactt tcaaggaaat gtcgcagaac tcatgattac aacagagttt gaattgaccg
    11041 gtcgcgaacg tgaagaagtc ttccttctca tggaacgcaa tctggaagtt atgaaagcct
    11101 ctgtccaact tggcctcaat gaaaataaat ctcgtagtgg cctgacaggt ggagatgctg
    11161 ccaaattgga tcactacatc gaaaacggaa aaactctgtc agattatacg attctctcgg
    11221 ctgcccgaaa tgccatcgca gtcaatgaac acaatgccaa aatgggcttg gtctgtgcca
    11281 ctccaaccgc tggaagtgct ggctgtctgc catccgttct cactgctgct attgaaaaat
    11341 tagacctcag ccacgagcaa caattggatt tcctctttgc tgctggtgcc tttggactag
    11401 tcatcgcaaa caatgcctcc atctcaggtg ctgagggtgg gtgtcaagct gaagttggtt
    11461 cagcctctgc tatgagtgct gccgccttga ctctggctgc aggtggaaca ccttatcagg
    11521 ccagtcaagc tattgccttt gtcattaaaa atatgctagg cctcatctgt gaccctgttg
    11581 caggtttggt cgaagttccc tgtgtcaaac gtaatgccat gggagctagc tttgctttca
    11641 tcgcagcaga catggccttg gcaggtatcg aatctaaaat ccctgtggat gaagtgatcg
    11701 atgccatgta ccaagtagga gcaagcatgc caactgcctt tcgtgaaaca gctgaaggtg
    11761 gactcgctac cacccctact ggtcgtcgcc tccaaaaaga aattttcgga gaataagctt
    11821 atcaaatagg agaaaccatg acctctatca cagcgatttt tttcgatttg gatggaaccc
    11881 tcgttgatag ttctatcggg attcacaatg cctttaccta tacctttaaa gagctggggg
    11941 tgcctagccc tgatgccaaa actattcgtg gttttatggg accacctctc gaaagtagtt
    12001 ttgcgacctg cctgtccaaa gaccaaattt ctgaagccgt gcagatatat cgttcttact
    12061 ataaggcaaa aggcatctat gaagctcaac tctttcctca gattgtagaa ttacttcaag
    12121 aactatccaa gaattaccct ctctacatca ccactacaaa gaatacacct accgctcaag
    12181 acatgacaaa aaacttggga atccatcatt tctttgatgg catttatggt tacagccctg
    12241 aagcacccca taaggcagat gtcattcacc aagccttgca gatacatcaa ctagcaccag
    12301 aacaagccat catcatcgga gataccaagt ttgatatgct gggagctcga gaaacaggta
    12361 ttcagaaatt ggccatcact tggggatttg gagagcaagc agatctacta aactatcaac
    12421 ctgattatat cgctcacaaa cccttagaag ttttggagta ttttcaataa catagactag
    12481 gcaacaactc catttcagaa gaaaatgaag taatactcaa tgaaaatcaa agagcaaacc
    12541 aggaaagtaa ccgcaggctg ctcaaaacac tgttttaagg ttgtagatgg aactgacgaa
    12601 gtcagctcaa aacactgttt tgaggtggca gatagaactg acgaagtcag ctcaaaacac
    12661 tgttttgagg tggcagatag aactgacgaa gtcagtaacc atatctacgg caaggcgacg
    12721 ttgacgtggt ttgaagagat tttcgaagag tataagtctc tacataataa aacgcatagt
    12781 accaaggtta acaaacttga tactatgcgt ttttcttttt tattcaatgt gggttgtttg
    12841 attagcaaag gcgataatag cttgcttcaa ctcatctcca ctgagagtgc ggaactctcc
    12901 aatcttttga ttgatggatt ctaaaggcat gacattaacc ttaccaacga aaatcttatc
    12961 cataacttga ttgtcaacga gttcggttga taccaagagt tcttcgtaga gtttttcacc
    13021 tgggcggatt ccaacttcaa cgattggaat ttcactttca gtgtggccac ttagaagcac
    13081 catcttcttg gccaagtcat aaatcttgac tggtttgccc atatcaagga taaagacttc
    13141 cccatctttg gcataagcac cagcatggat aaccagacgg ctagcttctg gaatggtcat
    13201 aaagtaacgg gtcatgcgga agtctgtcac cgttacaggc ccaccttcag caatctgacg
    13261 ttcaaagact ggaatgacac taccacggct accaagaaca ttcccaaaac gaactgcaca
    13321 gtaggttgat tggctacgtt ggttaaagcc agtgacaatc aactccgcca cgcgcttggt
    13381 tgctcccata acatttggtg gattgactgc cttatctgtc gaaatcataa ccatcttaga
    13441 cactttagct tcatcaacag ccttagcaac attgtaagtt ccacggatat tgtttttgaa
    13501 ggcttctttt ggattgcgct ccatcatagg aacatgcttg tgggctgccg catgataaac
    13561 aatagcaggt ttgtactgct caaagacttg caacaaacga tcatagtctt gaatgtccgc
    13621 aatcacaggt acataatcaa tcccttggaa cttacgaatc aattcatgat aaacaaggta
    13681 gattgagttt tccccatgac cgagcaagac aatgcgttca ggattgaagc gactaacttg
    13741 acgacagatt tcagaaccga ttgaacctcc agctcctgtg actaagatgg tcttacctgt
    13801 cagttctgca cccagacgcg attcgtcaag acggatttcc tgacgaccca aaaggtccat
    13861 aatatcaatt ttttggaagc cagtacctgc ttggtgaagg ccctgaacaa cagtttcaac
    13921 cttaggcatc ttgtaacatt tgacacccag cttattacac atctgcaaga tacgctcata
    13981 ttctgacgga tccagcgacg gaatcgcaac gatgacacgc tcgatttgat ggcgtttggc
    14041 taattcaggc agattgtcat aagagcccaa aacaggaata ccaccaagtt tttgaccctt
    14101 tttcttagaa tccttatcca aaataccgac cagttctaat tcactggttg gatgttggta
    14161 actatccata aagagagccc caccatcacc ggcaccaatc aagaaggtcc gacggtgttc
    14221 tccatcacca ctaccttttt tgcgtctgga gtagattaac tgccaagtaa tccgtggcaa
    14281 taaaatcaag aaggtactca acaagataaa gagaatgata aaacggatgg agaagagtgg
    14341 caagaaggca taacagatac tatatgacaa gacactgcta gcagtcacac caaaaaagat
    14401 tttcatgaaa tccgtaatct tgctgtaacg actaatgctc gcgttcaacc cccaaaaacc
    14461 aatcatcaat tgatagaaca ggaaggccaa actcgtatag ataatgtagt caacaggtgc
    14521 tggattaatc agcccataaa ataaaatata agatacaatg atggaaacca ccatactgaa
    14581 aatatcaaat attccccaga aaacctgctt ttgttgttta tttaaaattt ccaccagatc
    14641 aatcacataa tctgttagtt ttttattcat agaaatctac tcctccttaa aagagtttta
    14701 ctatattgtt attatagcat atttttattt atttggctta ttttatccaa ataaattatt
    14761 gttctcttgt actccttctt ccatttaaat cctctaatta aacctacaat cgtcccaaag
    14821 ccataagcaa agtgaatgga aaataaaaga aagggcatca caattagaaa tccattttta
    14881 tgttttaata aagtcagcaa agtgagtagt gacaaaagta gaaaataggc acctaatagt
    14941 aaagttatga atacgaatgt gatcggtaac aatgctagac taaacacaag actcaaaaca
    15001 aataaacaag gaacatagtg aaataatgat aaacacttaa actgaacatg acttgtcaag
    15061 ccaatccaca aaccatttaa atacttttga tgcagcattt tcttgaatgt tggtcgaata
    15121 tactgataag atagaatact tgggctatag cggattttat aaccatattc tcgaattcta
    15181 taatgaatat cattatcttc agttcggcca agttgctcat ttactaaacc aaccttctgg
    15241 aaaacctctc gtttatacat tccatgaaaa atagaagaaa catatctatc ctcagaacta
    15301 tttcgataat tggcaatgct actgccaaac atattttcct caacaagatg caaggtctct
    15361 gcccattttc cttttccttc gacaatcgtc ggtctaggcc ccccacagac aaattcacct
    15421 tgttgaataa tagccacatt gttcattaca aaagtctcag taacttttga atgagcatca
    15481 atttttaaaa taaggtcccc tacagaatgt ttaactccca ggttaaaacc actagcttga
    15541 tttttcttag gattgttata caatctaatt gagttaaact ctgtatcttc ctttataaat
    15601 tgctgaatga tagctgtggt cccatctgtg gacatagcat ttataaatag aatttcaata
    15661 ttctctttag gataggtttg attttttaag tcttcaatta gaccaggcag atatttttct
    15721 tcattgtatg cactgattac aatggatacg agaagacttt caacattttg agtcactact
    15781 actctcctga atttttcctt ccaccattct atcataattt tcaagacttt cccattttta
    15841 tcttgaaagc cagaaacctt acttgacatt atagtgaaaa agccttaaaa taagctgtta
    15901 ttaaaatcag ctagaagagg tattatatga aaaagcaatc actctttttt gttccaggta
    15961 ttatcctgat tggtgtttcc ttgcgaactc cttttactgt tttacccatt attttgggaa
    16021 atatttcgca aggtctggag gtagaagtta gttcgcttgg tgtcttgacc agcctgcctc
    16081 tccttatgtt taccctcttt tcaccatttt ctacccaact ggctcagaaa atcggcttgg
    16141 agcatctctt cacctacagc ctcttcttct tgaccatcgg ctcacttatt cgactaatca
    16201 atctgcccct gctctatcta ggaaccttga tggttggggc aagtgtcgca gtcatcaatg
    16261 tcctgcttcc tagtcttatc caagccaatc aaccaaagaa aattggtttt ctgaccacct
    16321 tatatgtaac gtctatgggg attgcaacgg ctctggcttc ctatctagct gtgcccatta
    16381 cacaagccag ttcttggaaa ggacttatcc tcctcctcac gttactctgt ctagcaactt
    16441 ttttggtctg gctcccaaat caccgctata atcatagact agctccacaa accaaacaaa
    16501 aaagtcaaat aaaggtcatg cgtaataaac aggtttgggc aattattatc ttttcaggtt
    16561 ttcaatcctt gatcttttac accgtcatga cctggttacc taccatgtct atccatgcag
    16621 gtctatccag tcacgaagct ggcttgctga cttctatctt atctctgatt agcattcctt
    16681 tttcaatgac catcccaagc ctgacaacca gtttatctac tcgcaaccgt cagctcatgc
    16741 tcactctggt ttcactagct ggtgtggtcg gcatttccat gctctttttc ccaatcaata
    16801 atttcattta ctggcttgcc atccatctcc tcatcggaac cgcaaccagc gccctcttcc
    16861 cttatctcat ggtcaacttt tcactcaaga caagcgcccc tgaaaagaca gcccaattgt
    16921 ccggcctatc tcaaacagga ggctatatcc tagcagcctt tgggccaacc ctctttggtt
    16981 acagttttga cctgttccac tcttgggtac catctgtagc tgccctcttg ctcatcgata
    17041 tcctgatgac tgtggccctc tttacagtgg acagagcgga taagatcctt taaacttcta
    17101 gttttagcta gaagtttttt atatataaaa attttacaca tttctcttga cagggctttc
    17161 ttttagatgt acaatgtatg tgtagaaaaa ttatatataa aaatcctaca cattagaaaa
    17221 ggaggtttcc catgtacttt ccaacatcct ctgccttgat tgaatttctc atcttggccg
    17281 tactggaaaa aggggattct tatggttatg agattagcca aaccattaag ctgatcgcta
    17341 atatcaaaga atccacactc tatcccattc tcaaaaaatt ggaaggcaat agctttctga
    17401 caacctattc tagagagttc caaggtcgca tgcgcaaata ctactccttg acaaatggtg
    17461 gtatagaaca gctcttgacc ctaaaagatg aatgggcact ctatacagac accatcaatg
    17521 gcatcataga agggagtatc cgccatgaca agaactgaat acctgactca gctagaactc
    17581 tatctcaaaa aactgcctga agctgaccaa attgaagcca tggactattt cagggaactc
    17641 tttgatgatg ctggagtcga aggagaggaa gaactcatcg ctagcttggg aactcccaaa
    17701 gaagcagccc acgaagttct ctctaatctt cttgataaaa aaatcaatga agcacctgct
    17761 caaaaaaata accgacaaat tttacatgtc gccttattag ccctccttgc agcacccatc
    17821 ggtattcctc tgggaatcgc catcctcgtg tccctgttcg caatccttgt ggcagccttg
    17881 actgtcatct tggctttctt tgcggtttcc atactgggta tcatcggtgg attcctattt
    17941 ttagttgaaa gtttcactgt cctagcccaa gccaaatcag cctttatctt gattttcggt
    18001 tctggtttac tggctatcgg tgcttcttca ctagtcttac taggtatttc ctatgtagcc
    18061 cgcttcttcg gtctactcat tgttcgcttg gtgcaatttg ttcttaaaaa aggaaagaga
    18121 ggtgaccagc atgcgtaaat tgacaaaagg atttctcatt tttggtgtcg tgactaccgt
    18181 tatcggcttt atcctgctct ttgtaggtat ccaatctgac gggattaaga gcctacttgc
    18241 catgtccaag gagcctgtct atgatagtcg gatggaagag ttaacctttg gcaaggaagt
    18301 cgaaaactta gagatcactc ttcaccagca cgcgctgacc atcacagact ctttcgatga
    18361 tcaaatccac atttcttacc atccatcact ttctgctcac catgatctta tcaccaatca
    18421 gaacgataga actctgagtc tcactgataa gaaactgtct gaaagtccat ttatctcttc
    18481 tggaattgat gggattctcc atattgtaag tagttcatct aatcgtttta atgatgtcat
    18541 catcggacta ccgaaaggga gaactctaaa agggatcaac atctcagcca atcgcggaca
    18601 aaccaccatc ataaatgcta gccttgaaaa tgcgaccctc aatacaaacg gctatatcct
    18661 ccgaattgaa ggaagtcgta tcaaaaacag taaactcaca acgcccaata tcgttaatat
    18721 ctttgataca gatcttacag atagtcagct agagtcaaca gaacatcact tccacgctga
    18781 aaatatccaa gtccatggta aggttgaact gactgccaaa gattatctcc gaatcatcct
    18841 agaccagaaa gagagccaac gaattaattg ggatgtctca agtaactatg ggtctatctt
    18901 ccaattcaca agagaagagc ctgaatcaag aggtacggaa ttaagcaacc cttacaaaac
    18961 tgaaaaaacc gatgtcaagg atcaactcat tgcgagatct gatgatgata ttgagctaat
    19021 atccacacca agcagacgtt gacaaaaacg cttacatctg ctactatgga aacatattta
    19081 tctaactaaa aaggaggttc taccatgaaa caagaatggt ttgaaagtaa tgattttgta
    19141 aaaacaacaa gcaagaacaa gcctgaagag caagctcaag aggttgcaga caaggctgaa
    19201 gaaaggatag ccgatctcga tacaccaatt gaaaaaaata ctcaagtaga ggaggaagtc
    19261 tctcaggctg aagtcgaact ggaaagccag caagaagaga aaatggaaac tcctgaagac
    19321 agtgaagcga gaacagaaat agaagaaaag aaggcatcta attctactga agaagagcca
    19381 gacctttcta aagaaacaga aaaagtcact atagctgaag agagccaaga agctcttcct
    19441 cagcaaaaag caaccacgaa agagcccctt cttatcagta aatctttaga aagtccttat
    19501 atccccgacc aagctccaaa atctagggat aaatggaaag agcaagtgct tgatttttgg
    19561 tcttggctag tggaggctct caaatctcct acaagcaagc ttgaaacaag tagcacacac
    19621 agctacacag cctttctctt gctcattctg ttttctgcat cttccttttt ctttagtatc
    19681 taccacatca aacatgctta ctatggacat atagcaacta taaacagcca cttccctgag
    19741 caactagcac ctttaactct cttttctatc atctctatcc tagtagcgac aacactcttc
    19801 ttcttttcat tcctcttggg tagtttcgtc gtgagacgat ttatctacca agaaaaggac
    19861 tggacgctgg aaaagattct ccaacaatat agtcaactct tggcaattcc aatcttcctc
    19921 actgccattg ctagtttctt tgctttcttt gacagcctac gattttcagc ccttttatgt
    19981 gtgattagca ttggaatcat tctgcttgct agtctccata tcattaccag accaagtcaa
    20041 gcaagtgaag ccgactcctt ctatcagtta ttcttgtctg tccttgtgaa cggagttatt
    20101 atcctcctct tctttgtagc tgaagtggca ctgattggaa attatcttcg tatcttggcc
    20161 tttctttaaa cttcaatcct gtcatccttg gcaggatttt ttctatgtca aaaaagcaag
    20221 tcgattgacc tgcttctgct ttacttttct tgtgctaatg ttttaaaatc ttgtcctagg
    20281 atgggtttta ttcctagagt tcaaagtatg atagcgttgc tataaagttc gttattccaa
    20341 atattatgca aactagttat atgtaaaatt aagattagaa accaccaatc tccatttatt
    20401 aacttttaat gaaattcgtc catattaata actttacttg ctctagcaat aacatccttg
    20461 tcatgagtca cgacaataac aatcttttcc tcgttcacta atttctcaac ctcgtttaga
    20521 aataattcag ttgagtttct gtccaaattt cctgtaggct catcgaatga atagatatcc
    20581 ttttcttgcg ataaactcct catgaataga attttttgtt tctgacctta cgaaatattg
    20641 gtggctttcc catcaatctg atgactcaga gctatattga gattcaaact atcaagatta
    20701 tttgattcat agttttcctt atcaaatagg gtgaaattaa tattttttgt catgcttcat
    20761 cacctccaga tatagtatta aa
//
LOCUS       DAVHIZ010000031        20140 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.033, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000031 DAVHIZ010000000
VERSION     DAVHIZ010000031.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 20140)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20140)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..20140
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.033"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            198..497
                     /locus_tag="VVO18_001295"
     CDS             198..497
                     /locus_tag="VVO18_001295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808250.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaB/EbfC family nucleoid-associated protein"
                     /protein_id="HEU5586454.1"
                     /translation="MMNMQNMMRQAQKLQKQMEQSQAELAAMQFVGKSAQDLVQATLT
                     GDKKVVSIDFNPAVVDPEDLETLSDMTVQAINSALEQIDETTKKKLGAFAGKLPF"
     gene            749..2075
                     /locus_tag="VVO18_001296"
                     /pseudo
     CDS             749..2075
                     /locus_tag="VVO18_001296"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436265.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(2390..3364)
                     /gene="pta"
                     /locus_tag="VVO18_001297"
     CDS             complement(2390..3364)
                     /gene="pta"
                     /locus_tag="VVO18_001297"
                     /EC_number="2.3.1.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004252952.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /protein_id="HEU5586455.1"
                     /translation="MEVFESLKANLVGKNARIVLPEGEEPRILQATKRLVKETEVIPV
                     LLGNPEKIKIYLEIEGIMDGYEVIDPQHYPQFEEMVSALVERRKGKMTEEDVRKVLVE
                     DVNYFGVMLVYLGLVDGMVSGAIHSTASTVRPALQIIKTRPNVTRTSGAFLMVRGTER
                     YLFGDCAININPDAEALAEIAINSAITAKMFGIEPKIAMLSYSTKGSGFGESVDKVVE
                     ATKIAHDLRPDLEIDGELQFDAAFVPETAALKAPGSTVAGQANVFIFPGIEAGNIGYK
                     MAERLGGFAAVGPVLQGLNKPVNDLSRGCNADDVYKLTLITAAQAVHQ"
     gene            complement(3408..4304)
                     /locus_tag="VVO18_001298"
     CDS             complement(3408..4304)
                     /locus_tag="VVO18_001298"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209987.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU5586456.1"
                     /translation="MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQ
                     NATYLLDVGDYVTIDIPAEKGFETLEAIELPLDILYEDDHFLVLNKPYGVASIPSVNH
                     SNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIE
                     KRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLV
                     DIRLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLDDGIQRQALHCHYLSFYHPFLEQDL
                     QLESPLPDDFSNLITQLSTNTL"
     gene            complement(4301..5119)
                     /locus_tag="VVO18_001299"
     CDS             complement(4301..5119)
                     /locus_tag="VVO18_001299"
                     /EC_number="2.7.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000799053.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD kinase"
                     /protein_id="HEU5586457.1"
                     /translation="MKNTGKRIDLIANRKPQSQRVLYELRDRLKRNQFILNDTNPDIV
                     ISIGGDGMLLSAFHKYENQLDKVRFIGLHTGHLGFYTDYRDFELDKLVTNLQLDTGAR
                     VSYPVLNVKVFLENGEVKIFRALNEASIRRSDRTMVADIVINGVPFERFRGDGLTVST
                     PTGSTAYNKSLGGAVLHPTIEALQLTEIASLNNRVYRTLGSSIIVPKKDKIELIPTRN
                     DYHTISVDNSVYSFRNIERIEYQIDHHKIHFVATPSHTSFWNRVKDAFIGEVDE"
     gene            complement(5103..5774)
                     /locus_tag="VVO18_001300"
     CDS             complement(5103..5774)
                     /locus_tag="VVO18_001300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000171686.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTP pyrophosphokinase family protein"
                     /protein_id="HEU5586458.1"
                     /translation="MTLEWEEFLDPYIQAVGELKIKLRGIRKQYRKQNKHSPIEFVTG
                     RVKPIESIKEKMARRGITYATLEHDLQDIAGLRVMVQFVDDVKEVVDILHKRQDMRII
                     QERDYITHRKASGYRSYHVVVEYTVDTINGAKTILAEIQIRTLAMNFWATIEHSLNYK
                     YQGDFPDEIKKRLEITARIAHQLDEEMGEIRDDIQEAQALFDPLSRKLNDGVGNSDDT
                     DEEYR"
     gene            5902..6471
                     /locus_tag="VVO18_001301"
     CDS             5902..6471
                     /locus_tag="VVO18_001301"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CYTH domain-containing protein"
                     /protein_id="HEU5586459.1"
                     /translation="MKHLEIELKTLLKKDEYNRLKDQFTGVTPVLQTNYYIDTPDFEL
                     REKKVAMRIRTFEDWAELTLKVPQSVGNMEYNQKLQLKDAENYLSKEELPQGLVLDEL
                     AKHGIQSKNWQVLGCLTTLRYEMKTAIGLMALDQSRYFDMTDYELELEVENHEQGKQD
                     FRQFLEKNQISYQKAPSKLVRFVKSMKNS"
     gene            6584..7543
                     /locus_tag="VVO18_001302"
     CDS             6584..7543
                     /locus_tag="VVO18_001302"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001280885.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEU5586460.1"
                     /translation="MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQ
                     VNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDR
                     IACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD
                     KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKA
                     ILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS
                     VATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK"
     gene            7553..8668
                     /locus_tag="VVO18_001303"
     CDS             7553..8668
                     /locus_tag="VVO18_001303"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000639661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine desulfurase"
                     /protein_id="HEU5586461.1"
                     /translation="MIYLDNAATTPMSAVAISAMTKVMQETHGNPSSIHGHGRQAGKL
                     LREARQELAQLLRTKPQHIFFTSGGTEGNNTTIIGYCLRHQEQGKHIITTAIEHHAVL
                     ETIDYLVQHFGFEATIIQPENQEITAQQIQKALRDDTILVSTMFANNETGNLLPIAEI
                     GQILKQHPAAYHVDAVQAIGKIPIHSEELGIDFLTASAHKFHGPKGIGFLYASSMDFD
                     SYLHGGDQEQKKRAGTENLPAIVGMVAALKEDLEKQEEHFQHVQNLETAFLAELEGIQ
                     YYLNRGKHHLPYVLNIGFPGQKNDLLLLRLDLAGISISTGSACTAGVVQSSHVLKAMY
                     GANSERLKESLRISLSPQNTVEDLQTLAKTLKEIIGG"
     gene            8673..9020
                     /locus_tag="VVO18_001304"
     CDS             8673..9020
                     /locus_tag="VVO18_001304"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1831 domain-containing protein"
                     /protein_id="HEU5586462.1"
                     /translation="MAFEKIIQLKNCRYDYTLSPSVKKFTLKDNTFFETKVGNYELTR
                     LLEKVPNSGEGFQLKIIINKELTGAKINITDKFGLRLVDIFKSEDHHIHQEKFYFLMD
                     SLVERGVFTKSER"
     gene            9028..9243
                     /locus_tag="VVO18_001305"
     CDS             9028..9243
                     /locus_tag="VVO18_001305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000462494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEU5586463.1"
                     /translation="MFELTYKDCYHVERTLKYEDHEALMLTLSGCVTLPDTLYVTSLT
                     FRGKKVYQGLVGDLYRFLSHADFLHQN"
     gene            9326..9967
                     /locus_tag="VVO18_001306"
     CDS             9326..9967
                     /locus_tag="VVO18_001306"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000653420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-sensing transcriptional repressor Rex"
                     /protein_id="HEU5586464.1"
                     /translation="MKDKQFAIPKATAKRLSLYYRIFKRFHAEKIERANSKQIAEAIG
                     IDSATVRRDFSYFGELGRRGFGYDVKKLMTFFADLLNDNSITNVMLVGIGNMGHALLH
                     YRFHERNKMKIIMAFDLDDHPEVGTQTPDGIPIYGISQIKDKIKDADVKTAILTVPSV
                     KSQEVANLLVDAGVKGILSFSPVHLHLPKDVVVQYVDLTSELQTLLYFMRKED"
     gene            9985..10674
                     /locus_tag="VVO18_001307"
     CDS             9985..10674
                     /locus_tag="VVO18_001307"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="gamma-glutamyl-gamma-aminobutyrate hydrolase
                     family protein"
                     /protein_id="HEU5586465.1"
                     /translation="MKKPVIGITGNEKTHPDDDIMMSYAAKGFVEGVKDAGGIPIILP
                     IGDQEMACHYISLIDKLILTGGQNVDPKFYGEPKTIDSDDYHLQRDIFELALIKEAIK
                     QKKPIFSVCRGTQLFNVAMGGTLYQDIEDHWQDSSVEYTTQRLVTEPDTVLQEIYGEI
                     SHINSFHHQSIKDLAPNLKVVAHDPKDGIIEAVMSTDDVAFLGVQWHPELLFENRPKD
                     KKLFDYVVNEL"
     gene            complement(10671..11351)
                     /gene="radC"
                     /locus_tag="VVO18_001308"
     CDS             complement(10671..11351)
                     /gene="radC"
                     /locus_tag="VVO18_001308"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000286923.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadC"
                     /protein_id="HEU5586466.1"
                     /translation="MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQASV
                     FEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEME
                     SILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILH
                     YAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFS
                     YREKTDLI"
     gene            complement(11394..13685)
                     /gene="pcrA"
                     /locus_tag="VVO18_001309"
     CDS             complement(11394..13685)
                     /gene="pcrA"
                     /locus_tag="VVO18_001309"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000992850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA helicase PcrA"
                     /protein_id="HEU5586467.1"
                     /translation="MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYL
                     IDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHI
                     GYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA
                     GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVD
                     EYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVL
                     LEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYRADDELDEAVFVART
                     IDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIA
                     YLNLIANLSDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKG
                     KAAQSIWDFANMMLDLREQLDHLSITELVESVLEKTGYVDILNAQATLESKARVENIE
                     EFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMTLHAAKG
                     LEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFG
                     RTNYNRPTRFINEISSDLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKR
                     GAAPKSIQSSGLPFGQFTAGAKSASSEANWSIGDIALHKKWGEGTVLEVSGSGARQEL
                     KINFPEVGLKKLLASVAPIEKKI"
     gene            complement(13876..14679)
                     /locus_tag="VVO18_001310"
                     /pseudo
     CDS             complement(13876..14679)
                     /locus_tag="VVO18_001310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            complement(15059..15919)
                     /locus_tag="VVO18_001311"
     CDS             complement(15059..15919)
                     /locus_tag="VVO18_001311"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903404.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionyl aminopeptidase"
                     /protein_id="HEU5586468.1"
                     /translation="MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYV
                     RRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLG
                     GPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDVTKEA
                     MYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAG
                     RGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVI
                     LTSQGEEGTY"
     gene            complement(15935..17212)
                     /locus_tag="VVO18_001312"
     CDS             complement(15935..17212)
                     /locus_tag="VVO18_001312"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain-containing protein"
                     /protein_id="HEU5586469.1"
                     /translation="MSKHQEILSYLEELPVGKRVSVRSISNHLGVSDGTAYRAIKEAE
                     NRGIVETRPRSGTIRVKSQKVAIERLTFAEIAEVTSSEVLAGQEGLEREFSKFSIGAM
                     TEQNILSYLHDGGLLIVGDRTRIQLLALENENAVLVTGGFQVHDDVLKLANQKGIPVL
                     RSKHDTFTVATMINKALSNVQIKTDILTVEKLYRPSHEYGFLRETDTVKDYLDLVRKN
                     RSSRFPVINQHQVVVGVVTMRDAGDKSPSTTIDKVMSRSLFLVGLSTNIANVSQRMIA
                     EDFEMVPVVRSNQTLLGVVTRRDVMEKMSRSQVSALPTFSEQIGQKLSYHHDEVVITV
                     EPFMLEKNGVLANGVLAEILTHMTQDLVVNSGRNLIIEQMLIYFLQAVQIDDILRIQA
                     RIIHHTRRSAIIDYDIYHGHQIVSKANVTVKIN"
     gene            complement(17205..17756)
                     /locus_tag="VVO18_001313"
     CDS             complement(17205..17756)
                     /locus_tag="VVO18_001313"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521687.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586470.1"
                     /translation="MNIWTKLAMFSFFETDRLYLRPFFFSDSQDFREIASNPENLQFI
                     FPTQASLEESQYALANYFMKSPLGVWAICDQKNQQMIGSIKFEKLDEIKKEAELGYFL
                     RKDAWSQGFMTEVVRKICQLSFEEFGLKQLSIITHLENEASQRVALKSGFSLFRQFKG
                     SDRYTRKMRDYLEFRYVKGEFNE"
     gene            complement(17772..19031)
                     /locus_tag="VVO18_001314"
     CDS             complement(17772..19031)
                     /locus_tag="VVO18_001314"
                     /EC_number="2.5.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864372.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="HEU5586471.1"
                     /translation="MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCV
                     PDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLL
                     GRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYM
                     DTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIID
                     GVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMT
                     VSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN
                     HVFELAKMDADISTTNGHILYTGGRDLRGASIKATDLRAGAALVIAGLMAEGKTEITN
                     IEFILRGYSDIIEKLRNLGADIRLVED"
BASE COUNT         6154 a         4373 c         3641 g         5972 t
ORIGIN      
        1 ttattttaat ttatttctaa tcactccttg acataaataa ctctcaccaa taaaagacta
       61 tgtcttaaaa aaatggtata ataaaatcaa tacttgggct tgatggctat gctactaata
      121 acaattagga gagaaaatca ggcacttgtt aacaacaagg attatcccct tgagatgaaa
      181 ggaactttag aaatcttatg atgaacatgc aaaacatgat gcgtcaagca caaaaacttc
      241 aaaaacaaat ggaacaaagc caagctgaac ttgctgctat gcaatttgtt ggcaaatctg
      301 ctcaagatct tgtccaagcg accttaactg gcgataagaa agttgtcagc attgatttca
      361 atccagctgt cgttgaccca gaggaccttg agactctttc tgatatgacc gttcaagcca
      421 tcaactctgc tcttgaacaa atcgatgaaa ctaccaagaa aaaactgggt gctttcgctg
      481 ggaaattacc tttctaaaaa caaggagcta gaacaatgct tgtcgataac aaaggctaag
      541 aaaggtgcaa aaatgactct ataatatttg tagtgggtaa atccactata gatattatgg
      601 agcctatttt attgtagaaa aaaagggctc tataatattt gtagtgggta aatcccctat
      661 ggatattatg gagcttattt ttgtgtagaa aaaaagtccc atatgaccta taatgaaaag
      721 cgacaaaacc atcattagaa agattcatat ggaacaatta cattttatca caaaactgct
      781 cgatattaaa gacccaaaca tcaagattct agatatcatc aatatggata cccacaaaga
      841 aattatcgct aagctggatt atgaggctcc atcttgccct gattgtggaa gtctaatgaa
      901 gaaatatgac tttcaaaaac cgtctaagat cccttacctc gaaacaactg gtatgccttc
      961 tagaattctc cttagaaaac gccgtttcaa gtgctatcac tgttcaaaaa tgatggttgc
     1021 tgagactccc ctgataaaga aaaatcacca aatccctcgt atcatcaacc aaaagattgc
     1081 tcaaaagtta attgaaaaga tttctatgac tgatattgcc catcagcttt tcatctcaac
     1141 ttcaactgtt attcgtaagc tcaatgattt tcactttaaa catgattttt cttgtcttcc
     1201 tgagattatg tcttgggacg ttgaaacagt ccgggtagtg actgtttcaa tcgggagatg
     1261 gagatgagct ttattgcgca agattttgac aagctcaata tcatcactgt tcttgaggga
     1321 agaacacaag ctatcattcg aaatcacttt cttcgctacg atagagccgt ccgatgtcgc
     1381 gtcaaaatca ttactatgga tatgtttagc ccttactatg gcttggctaa acagcttcgc
     1441 tttcaaattt ctaggctcag gctgaaacag tctcccagac tgtttcactc ccgaatgcta
     1501 aaatcgttct tgatcgcttt cacattgtac aacatcttag ccgtgctatg agtcgtgtgc
     1561 gtgttcaaat catgaatcag tttcatcgaa aatcccatga atacaaggct atcaagcgct
     1621 actggaaact cattcaacag gatagccgta aactgagtga taagcgattt tatcgtccta
     1681 cttttcgtat gcacttaacc aataaagaga ttttaaacaa gcttttgagt tattcggaag
     1741 acttgaaaca ccactatcaa ctctatcagc tcttgctttt tcacttccag aataaggaac
     1801 cagagaaatt tttcgggctt attgaggaca atctaaagca ggttcatcct ctttttcaga
     1861 ctgtctttaa aacctttcta aaggacaaag agaaaatcgt caacgccctt caactaccct
     1921 attcaaacgc caaattggaa gcgaccaata atctcatcaa acttatcaaa cgcaatgcct
     1981 ttggttttcg aaactttgaa aacttcaaaa aacggatttt tatcgctctg aacatcaaaa
     2041 aagaaaggac gaaatttgtc ctttctcgag cttagctgac ttcaacccac tacagttgac
     2101 aaagagccag aaaacgcata atagcaggtg tcaagacact taatattatg cgttttctca
     2161 tgaaaaaatt ctcttttcat actcatttaa aatcaaaaag ggaaattatc gttttacgga
     2221 catacatatt acagatttct ataggtcgtg tatagacagg atatcatcgc ttggaagttt
     2281 tcctttttga caccaatcag taatttagtt ctcaggaatt aatggcagtg cttttcgtac
     2341 atagtttcat aactacagta tagcatagta tatcgcttta tagttttcac tattgatgaa
     2401 ctgcttgagc tgctgtgatg agggtcaact tgtaaacatc atctgcatta catccacgag
     2461 aaagatcatt aactggcttg tttaaacctt gcaaaacagg tcctacagcc gcaaagccac
     2521 ccaggcgttc agccatcttg taaccgatat ttcctgcctc gatacctggg aagatgaaga
     2581 catttgcttg accagctacc gtacttccag gagctttcag agctgcagtt tcaggaacaa
     2641 aggctgcatc aaattgcaac tcaccatcga tttcaaggtc aggacgcaag tcgtgagcaa
     2701 ttttagttgc ttcaacgacc ttatcaacgc tttcaccaaa ccctgaacct ttagtagaat
     2761 agctcaacat ggcaatttta ggttcgatgc caaacatctt agctgtgatt gctgagttga
     2821 tggcaatttc agccaaggct tctgcatctg gattgatgtt aatggcacag tctccaaata
     2881 ggtaacgttc cgtaccacga accatgagga aggctcctga agtacgagtt acatttggac
     2941 gagttttgat gatttgtaga gctggacgaa ctgttgaagc tgttgagtga atcgctcctg
     3001 acaccattcc atcaaccaag cccaagtaaa ccaacatcac accaaagtag ttgacatctt
     3061 caaccaaaac cttgcgtaca tcttcttcag tcattttgcc cttgcgacgc tccaccaagg
     3121 cagaaaccat ttcttcaaat tgaggataat gttgagggtc gatgacctca taaccatcca
     3181 tgatcccttc aatttcaaga taaattttaa ttttttcagg atttcctaac aaaacaggaa
     3241 tcacttctgt ttcttttacc aaacgtttag tcgcttgaag aatacgtggc tcttcccctt
     3301 cagggagaac gatacgagca tttttaccaa caaggttggc tttgagactt tcaaaaactt
     3361 ccatgagttt tctcctttaa gataataatt atactctgaa acagttttta tagagtatta
     3421 gttgataact gggtaataag gttgctgaaa tcatccggca agggactttc taactgcaaa
     3481 tcttgctcta aaaatggatg ataaaaggat aggtaatggc aatgcagggc ctgacgttgg
     3541 atgccgtcgt ccagactacc accgtacaaa tcatcgccca acaaaggaaa accaatatga
     3601 gaaaagtgga ctcgaatttg gtgggttcga ccagtgtgca gccgaatgtc gaccaagtgg
     3661 atatttccat aagaagctac aatcttgtag gaagtatggg catattttcc acctttagcc
     3721 acccgtctgg taataatgga gtcttcatca cgcgcaatcg gagcaataat ttccccttct
     3781 ggctccaaat gtccatctcc cttaaccaaa gcaaagtagc gtttctcgat agatttcttc
     3841 tgcaactgct tgtctaatcg tgcatgggca taaccgtgct tggcaaagag catcaagcca
     3901 gaagtgtccc tatctagtct ggtaacaatg tgaacctgct gattttcata attttgcttg
     3961 acatagtaac ccttgataaa attggcaatg gtattagagt gattgacact aggaatagaa
     4021 gccactccat agggtttatt caagactaga aagtggtcat cctcatagag aatatctaat
     4081 ggaagctcaa tagcctccaa ggtttcaaag cctttctcag cgggaatgtc aatggtaacg
     4141 tagtctccaa cgtccaatag atacgttgca ttttgcggtt gattattgac cagaatagct
     4201 ccacctcgaa acttaatctt ggccagcaat cccttagaaa cctcgtgctt ttttaaaaag
     4261 gtcttaacct tgacatgttc atctgcgata aattcaaacc tcattcatcc acctcaccga
     4321 taaaggcatc cttaacacgg ttccagaaac tggtatggct aggagtcgcg acaaagtgaa
     4381 tcttatgatg gtcgatttga tactcaatac gctcaatatt acggaaagaa taaacgctat
     4441 tgtcaaccga aatagtatga taatcgtttc ttgttggaat aagttcaatc ttatccttct
     4501 taggcacaat aatggaagag cccagtgttc gataaacacg attattaagg ctggcaattt
     4561 ccgttaattg caaagcttca atggtagggt gtaaaacagc accgccaaga gacttgttat
     4621 aggcagtact accagtcggt gtcgaaactg ttagcccgtc tccacgaaaa cgttcaaagg
     4681 gaacaccatt tattacaata tctgccacca tggttcgatc agacctgcgg atgctggctt
     4741 cgttgagtgc tctgaaaatc ttaacttcac cattttcaag aaagaccttc acattcagaa
     4801 cagggtaaga aacccttgcc ccagtatcta gctgcaaatt agtcactagc ttgtccaact
     4861 caaaatcacg ataatctgta tagaagccca aatgtccagt atgaagaccg ataaagcgga
     4921 ccttgtcaag ctgattttcg tacttatgaa aggccgacaa gagcatacca tccccgccaa
     4981 tggaaatgac aatatccgga ttggtatcat tgagtataaa ctgatttctc ttcaaacgat
     5041 ctcgcaattc atacaaaacc ctttgactct gcggttttct attggctatc agatcaattc
     5101 gtttacctgt attcttcatc tgtatcgtca ctgtttccta caccgtcatt taattttcta
     5161 ctcaaaggat caaaaagtgc ctgggcttct tggatatcat cacgaatttc acccatttct
     5221 tcatccaact gatgggcgat tctagctgta atttccagtc gcttcttaat ctcatctggg
     5281 aaatcccctt ggtacttgta gttgagagaa tgttctatcg ttgcccagaa attcatggcc
     5341 aaagtacgaa tttgaatttc tgccaaaata gtcttagctc cattgatggt atcaaccgta
     5401 tattctacta ccacatgata ggaacgatag cctgatgctt ttctatgagt aatataatct
     5461 cgctcctgta tgattcgcat atcctgacgc ttgtgcaaaa tatccactac ttccttgacg
     5521 tcatctacaa actgaaccat cacacgtaag ccagcaatat cctgcaaatc gtgttccaag
     5581 gtcgcataag taatgccacg acgagccatt ttttctttga tgctctcaat tggcttgact
     5641 cgaccggtca caaactcaat tggagaatgc ttattttgct tacgatattg cttacgaata
     5701 ccacgaagtt taatctttaa ctcaccaaca gcttgaatgt aaggatctag aaattcttcc
     5761 cattctaagg tcatatattc tcccttgttc tcatattatc cgtcaaaaat atctttgatt
     5821 ttttctccag attcatatac aataaataca atgcttatta taccataaat ccgctttcaa
     5881 cgataaaaaa aggtaagaaa aatgaaacat ttagaaattg aattgaaaac actattgaaa
     5941 aaagatgaat acaatcgtct aaaagaccag ttcacaggtg tcactcctgt tcttcaaaca
     6001 aattactaca tcgacacgcc tgattttgaa ctgcgagaaa agaaagtcgc tatgcgcatt
     6061 cgaacctttg aagactgggc tgagttgaca ctcaaagtcc cgcagagtgt tggaaacatg
     6121 gaatacaacc aaaaattgca actaaaagat gctgagaact atctgagtaa ggaagaactt
     6181 cctcaagggc tagtactgga tgaattggcg aaacatggta tccaaagtaa gaactggcag
     6241 gttcttggtt gtctaacaac gcttcgctat gaaatgaaaa cagctattgg tctcatggca
     6301 ctggatcaga gccgatactt tgatatgaca gattacgaat tggagcttga agtggaaaat
     6361 catgagcaag gcaaacagga tttccgacaa tttttagaga aaaatcagat ttcctaccaa
     6421 aaagctcctt caaaattggt tcgatttgtc aaaagtatga aaaatagctg aaataatctc
     6481 cattttttgg taaaatagaa aagataaaaa tacacaaatc ccagttcata tatgtaaggt
     6541 aaatataact aggatttata aagtttacag aggacggtct ataatgtcag atagaaaaaa
     6601 catgaaactt ttcgcactca actctaacca agagattgca caaaaaattg cccaagctgt
     6661 tggtgtccca cttggaaaac tatcatcacg tcaattttca gacggagaaa tccaagtaaa
     6721 tatcgaagaa agtgtccgtg gttatgatgt ttacatcatc caatcaacaa gtttccctgt
     6781 caacaaccac ctaatggaat tgttaatcat ggtcgatgct tgtgtgcgtg caagtgccca
     6841 cagtatcaac gttgtccttc catattttgg ctatgcacgt caagaccgca ttgcttgtcc
     6901 tcgtgagcca cttacagcaa aactagttgc caatatgctg gttaaggctg gagttgatcg
     6961 tatcctgact cttgatttgc atgccgttca ggttcaaggt ttctttgata ttccagtgga
     7021 taatcttttc actgttcccc tattcgcaaa acattactgc gataaaggat tgcttggttc
     7081 agatgttgtt gtcgttagcc ctaaaaattc aggtgtcaaa cgtgcgcgta gcctggctga
     7141 atatcttgat gctcctatcg ccattatcga ctaccctcaa gacgatgcaa ctcgtaacga
     7201 aggttatatt attggtgatg ttgaaggtaa gaaagctatc ttgattgatg atattttaaa
     7261 tacaggacgt accttctctg aagcttctaa aatcgttgaa cgtgaaggag ctacagaaat
     7321 ttatgctgtt tctagccacg gtctcttcgt cgagggagct gctgagcttc ttgacaatac
     7381 taatattaaa gaaattcttg tgactgattc agtagcaaca aaagaaaaaa ctcctaaaaa
     7441 tgtatgctac atcactgcta gtgagttaat tggtgatgct atcgtccgta ttcacgaaag
     7501 aaaaccagtc agcccactct ttgcctacaa taaaaagaaa taaggtgatt ctttgattta
     7561 tttggacaat gctgcaacga ctcctatgtc agcagttgct atttcagcta tgaccaaggt
     7621 tatgcaagaa acccacggaa atccttctag tattcatggt catggtcgtc aagctggcaa
     7681 actcttgcga gaagcccgtc aggaactagc ccagttacta aggacaaaac ctcaacatat
     7741 ctttttcact tctggtggga ctgaaggcaa taatactacc atcattggct actgtcttcg
     7801 tcaccaagaa caaggaaaac atatcatcac aactgccatc gagcaccatg ctgtccttga
     7861 aacaattgat tacttggttc aacactttgg gtttgaagca accattatcc agccagaaaa
     7921 tcaagaaatc acagcccagc aaattcaaaa ggctttacgt gacgatacga ttttggtttc
     7981 tactatgttt gccaataatg agacaggaaa cctacttccc atcgctgaaa ttggccaaat
     8041 actcaagcaa caccctgctg cctatcatgt tgatgcagtt caggctattg gtaaaatccc
     8101 aattcattca gaagaattgg gcattgattt tctcactgct tctgcccaca aattccatgg
     8161 tcctaaggga atcggttttc tctacgcatc tagcatggac tttgattcct atctacatgg
     8221 cggagatcag gaacagaaaa aacgtgcagg aactgaaaat ctgcctgcca tcgtaggcat
     8281 ggttgcagcc ctaaaagaag acctagaaaa acaagaagaa cattttcaac atgtacaaaa
     8341 tctagaaact gcctttctgg cagagctgga gggcattcag tattacttga atagaggaaa
     8401 acatcatctc ccttatgttc tcaatattgg atttcctggt cagaaaaatg acctcttact
     8461 ccttcggcta gatttagctg gaatttcaat ctctactggc tcagcctgta ctgcaggcgt
     8521 tgtccaatcc agccatgttc ttaaagccat gtatggcgca aattcagaac gcttgaagga
     8581 atcccttcgc atcagtttgt cgccacaaaa taccgttgaa gacctacaaa ccctcgcaaa
     8641 aaccttaaaa gaaattatcg gaggttagcc atatggcatt tgaaaaaatc attcagttaa
     8701 aaaattgtcg ttacgattac actcttagcc cttctgttaa aaaattcacc ctcaaagata
     8761 acaccttttt tgaaactaag gttggtaact atgaactgac tcgccttttg gaaaaagtgc
     8821 caaacagcgg tgaaggcttc caactcaaaa tcatcattaa caaggaactt acaggggcta
     8881 aaatcaatat cactgacaag tttggccttc gtctagttga tattttcaaa tcagaagacc
     8941 accatattca tcaggaaaaa ttctacttcc tcatggatag cttggtagaa cgtggtgtct
     9001 ttacaaaatc ggaaagatag agccaaaatg tttgaactga cctataagga ctgctatcat
     9061 gtagagcgta ctctcaagta tgaggatcat gaggctctca tgttgacttt gtcaggatgt
     9121 gtaaccttac cagatacact ttatgtgact tctctgactt ttaggggcaa aaaagtttat
     9181 caggggctgg tcggagacct ctaccgtttt ctatctcatg cagatttttt acatcaaaac
     9241 taagattttt cttagttttt tcttattttt gttgattttt tcacaatgtt tctataaaat
     9301 agaagaatag aaaggttgtg attttgtgaa agataaacag tttgctattc caaaagctac
     9361 agcaaaaaga ctctctctct actatcgaat ttttaagaga tttcatgcag aaaagattga
     9421 acgtgccaac tctaagcaaa ttgcagaggc tatcggtatt gattcagcga ccgtacgtcg
     9481 tgatttttcc tattttggtg aacttggtcg tcgtggtttt ggctatgatg tcaaaaaact
     9541 aatgacattt tttgccgatt tgctcaatga caactctatt accaatgtca tgctggttgg
     9601 tattggaaat atgggccatg cccttctcca ctaccgcttc cacgaacgta acaagatgaa
     9661 gattatcatg gcctttgacc tagacgacca tcctgaagtc ggtacccaaa ctcctgacgg
     9721 gattcccatt tacgggattt ctcagatcaa ggataaaatc aaggatgctg atgtgaagac
     9781 tgctatccta actgttccca gcgtcaagtc acaagaggtt gctaatctct tggttgatgc
     9841 tggtgtgaaa ggaattctca gtttttcacc agtccatctg catttaccaa aagacgtggt
     9901 cgttcagtat gtcgatttga caagtgaact ccaaaccctc ctctacttca tgcgaaaaga
     9961 ggattagaaa gcgaaaatca ttttatgaaa aaaccagtta ttgggattac aggaaacgaa
    10021 aaaactcatc cagatgatga catcatgatg agctacgcag caaaaggctt tgttgaaggc
    10081 gttaaagatg ctggagggat tcccatcatc ctaccgattg gtgatcaaga aatggcctgc
    10141 cactatatca gtttgattga caagctcatc ttgacaggtg ggcaaaatgt cgatccaaaa
    10201 ttctatggcg aacccaaaac cattgatagc gatgattatc accttcaaag agatatcttc
    10261 gaactggccc tcatcaagga agctattaaa cagaaaaagc ccattttctc tgtctgccgt
    10321 ggtacccaac tctttaacgt tgccatgggt ggaactttgt accaagatat cgaagaccat
    10381 tggcaggatt cttctgttga gtacacaact caacgcttgg taacagaacc agataccgtt
    10441 ctccaagaaa tctatggaga aatctctcat atcaactcct tccaccacca gagcatcaag
    10501 gacttagcac caaatttaaa agttgtggct catgatccta aagatggtat cattgaggct
    10561 gtcatgagta cggatgatgt cgcctttctc ggtgtccaat ggcatccaga acttcttttt
    10621 gaaaatcgtc ccaaagataa gaaactcttt gactatgtcg ttaatgaact ttagattaaa
    10681 tctgtctttt cacgataact aaagtaatta gaatgagaga caatcaaatg gtccaagaga
    10741 acaatcccca tcagttcgca ggcttcttta acaagtttag tgacatgatc atcattttgg
    10801 ctaggcgcta ccgctcctga aggatgattg tggaccaaga taagagaagt cgccatatgc
    10861 ttgattgcat agtgcagaat ctctcgcggt tcagcgatac tacgagttac agaaccgata
    10921 aaaatggtct gctgatggat gatttgattt tgagtattga gatagagtgc caccaggtgc
    10981 tcttgttttt tatcccctaa ttcctgctgc atcttcttgg ccaacttttg actgctgaga
    11041 atactttcca tttcaagagt ctcgtgtttg tgaatacgat gccccagttc aatcatagct
    11101 tgtaattcta tggccttaac acgcccaata ccagacaaac tctgcaattc ctgcagggtc
    11161 atttttttca aatccgttag gcttgaaaga ttgttcaaga ctttttgggc aatttcaaaa
    11221 acgctagctt gacgtgttcc tgtcctgagt aaaatagcta gcaactcttg gttactaagc
    11281 gcttcaactc cttccttggc cagcctttct cttggtaata gtgaatcttc ttggaatgaa
    11341 atactgtaca taaaaatcct cctcacttta ttattcgtga gaaggatgga aaattagatt
    11401 tttttctcaa ttggagccac actggctaaa agttttttca aacctacttc tgggaaattg
    11461 attttcaatt cctgcctagc accgctacct gaaacttcca gaacagttcc ctctccccat
    11521 ttcttgtgga gagcaatgtc accaatggac caatttgcct cgctagatgc tgattttgcg
    11581 ccagctgtaa attgaccaaa tggaagaccg cttgactgga ttgattttgg ggcagcaccg
    11641 cgtttacggt cttgaagagc ctgagccaaa ctcatacctt gaccaaagga aatactacca
    11701 ctgctatatg atgccttaaa gcttgtattt gcaggacgag ccagaccttg atactcaagc
    11761 aagtctgaac tgatttcgtt aataaaacga gtcggacggt tataattggt acgaccaaaa
    11821 agcaagcgtg agttggcatt ggtcagatag agaattttct ctgcacgcgt gatacctaca
    11881 taggctagac ggcgctcttc ttctaattca tctggatctt cagtcgcacg actaagtgga
    11941 aagacatttt cttccatccc aatcaaaaag acaactggaa attcgagacc tttggcagca
    12001 tgcagggtca tcaaggtcac ttctgatgtc tcctgactac ctgaatctgt gtcggcaatc
    12061 aaagccaagt catttaagaa acgactcagt ttgtccagac cagtttcctc ttctgtcaca
    12121 tccgtggtgt catcaaagtt cttcgtaaca gaaagaaact cttcgatatt ttcaacccgt
    12181 gccttgcttt ctagagtcgc ttgggcgtta agaatatcga cataacctgt tttttctagg
    12241 acggactcaa ccaactctgt aatgcttaag tggtctagct gctcccgcaa atcaagcatc
    12301 atattggcaa aatcccagat agattgggct gccttaccct tgataccaga caacataata
    12361 ttagcagaag catccagcat agacatattt tgcaaatttg caaaatcacg gattttctca
    12421 actgtaccta gaccaattcc acgtttaggc tcgttgataa tacgctcaaa actaatattg
    12481 tcactcaaat tagcaataag gttgagataa gcaataatat cgcgaatttc cttacggctg
    12541 tagaatttgg ttccgccaac catggtataa ggaatgttag acttgagcag ggcttcctca
    12601 attgtacggg actgggcatt agtccgatag agaactgcaa aatccttatg aaggaagttt
    12661 tgactgcgac taagttcatc gatggttctg gctacaaata cagcctcatc cagctcatca
    12721 tcggcacgat agtaaacgat ttgctcccca tcagcgtttt gagtccagag atttttagga
    12781 cggcgatttt tattgttttt aataacctcg ttggccgctt ggagaatggt tttggttgag
    12841 cggtaatttt cctccaacaa aacaaccttg gctttggggt aatccttttc aaagtccaag
    12901 atattctgca tatcagcacc acgccaaccg tagatagact ggtccgcatc cccaaccaca
    12961 cagatatttt taaaacggga agccaagagt ttgaccaatt ggtactgagc gtggttggta
    13021 tcttggtact catcaacgtg gatgtattgg aatttttgct ggtagtaggt caaaacatca
    13081 ggattttgat caaagagacg caaggtcagc ataatcaaat catcaaagtc aacggattcg
    13141 gactgacgaa gttctttttg ataggctgta taacactggg ccacaatttg cgtatacata
    13201 tcgccagctt gggcagcata agcaacatca tcaatcaaat cattcttagc attggaaatg
    13261 gtccccaaaa tagttcgttc attccatttt ttaggatcca agttcaactg ttttagaata
    13321 cgtttcatga gcgttcgctg ttcaccagga tccacaattg taaaattacg attgtagcca
    13381 atatggtccg catctcgacg caaaatacgc acacacatgg agtggaaggt cgcaatcaga
    13441 cagtcctgag tagctggatt gaggctataa gcacgctctt tcatctcacg cgcagccttg
    13501 ttggtaaagg taatggccaa gatattccaa ggattgacca gcttttcatc aatcaaataa
    13561 gcgatacggt gggttaaaac acgagtcttt ccagaaccag cccctgccat gattagcaag
    13621 ggaccttctg tcgtttgcac cgcctcagcc tgacggtcat tcattccatt taataatgcg
    13681 ttcatcttct cttccttact cttgaagtca atatttctat tatatcagaa atcagggaaa
    13741 atagaaactt tacggggagt agcaaaatat agtggattga aactagaata ctacactgtg
    13801 ggtttctaaa acactcgact tttcacccaa ttttttcata aactagctca atacctcaat
    13861 agacttcctg caaaactaga atcctagttc atgattgata ataccagcaa tcaaattcat
    13921 tcgtaatccg aagcgtttac gatgatttcg ataagttgtt gaaaacattt taaacgtttt
    13981 tactttggca aagatgttct caaccttgct tctctcctta gatagcgcat ggtttaagcc
    14041 ttatcttcaa ctgttagcgg cttgagtttg ctgaatttac gtggagtttg tgcttgagga
    14101 tatatcttca tgagcccttg ataaccactg tcagccaaga ttttaccagc ttgtccgata
    14161 tttctgcgac tcattttgaa caacttcata tcatgacaat agttcacagt gatatccaaa
    14221 gaaacaattc ttccttgact tgtgacaatc gcttgagcct tcatagcgtg aaatttcttt
    14281 ttaccagaat aattcgctaa ttcttttttt agggcgattg gtttttactt ccgtcgcatc
    14341 aatcattacc gtgtcctcag aactgagagg agttcttgaa atcgtaaaac cactttgaac
    14401 aagagttact tcaacccatt ggctccgacg gattaagttg ctttcgtgaa taccaagatc
    14461 agccgcaatt tgttcataag ttcgatattc tcgcacatat tgaagagtgg ccataagaag
    14521 gtcttctagg cttaatttag gttttcttcc accttttgca tgtttaagtt gataagctgt
    14581 ttttaataca gctaacatct cttcaaaagt ggtacgctga acatcaacaa gacgcttaaa
    14641 tcgtgcatca gttagttgtt tacttgcttc atcattcata gaactactat accatgtttt
    14701 gtttcgcagg aagtataata taaaaaaata aatttaagat tggcaatacg aacgttaaac
    14761 agaattccat ttctcttttt agaatcaaaa cgacaatatt gtgaaatctc tacaggaaca
    14821 atagactgcg acactaaaat atcctccctt agttttactt tactaatagt atataggagg
    14881 agagccctga atcctagacc ctttgttatg atgcgcttac aaacagagtt ggaaaaaatc
    14941 ttaaaagcag aaaaacgcat gatatcagcc cctaacactt gatacaatac gttttattat
    15001 gaaaagatct actggatttt ttatcaaaat aaacttccag tagtcttttc actttttatt
    15061 aataagttcc ttcttcacct tggctagtca agataacagg tccatctttc gtaatgacaa
    15121 attggtgttc atactgacat gacaatccac cgtcaatggt cttatgcgcc caaccagttt
    15181 tcatatctgt atcaatttcc caatcgcctg tattgatcat tggttcaatg gttaagacca
    15241 ttccttcacg aagacggagt ccacgacctg caataccata gttaggaacc attggttctt
    15301 cgtgcatagt tgggccaaca ccatgaccaa ccaaatcacg cactacaccg taaccacgac
    15361 tttcagcgta ttcttgaata gccgcaccga tatcaccgat acgatttcca acaacagctt
    15421 gctcaatacc cttgtacata gcttctttgg ttacatccat caagtttttg acttcttcgg
    15481 acggtgtacc aacagcataa gcccaacatg agtctgctaa accaccagaa tagctctgag
    15541 tatatttttt catttgttca acattgttga agtttaattt tgagacattc aggtcagatt
    15601 tagcaatggg acctcccaaa accatatcaa ctttgagcaa atcaccatct ttcaagatat
    15661 aatgacgagg gaaagcgtga gccacttcat cgttaagaga gcaacaggta gcataaggat
    15721 agtccatcat ggcaccgtca accccaatct gaagtggaag gaaattttct tctttacaac
    15781 gacggcggac atattcttca acttcccaca tatctacgcc tggcttaatc aaatcacgta
    15841 agcctatatg aatacttgct agaaaatcac cagccttgtc catagcttcg atttcacgag
    15901 ctgattttaa tgttatcatc ttttctccta gtttctaatt aattttaaca gtcacatttg
    15961 cttttgaaac aatctggtga ccatgataaa tatcgtaatc aattatagct gaccgtctcg
    16021 tatgatgaat aatccgtgcc tgaatgcgca atatatcatc tatctgaaca gcctgcaaaa
    16081 agtagatcag catctgctcg ataatgagat tgcgaccact attaacaact aaatcttggg
    16141 tcatgtgggt cagaatttct gccaatacac cattagccaa aactccattt ttttctagca
    16201 taaagggttc cactgtaatg actacttcat catggtgata agagagcttt tgtccaatct
    16261 gctcagaaaa agttggtaga gccgaaactt gggaacggct catcttctcc atgacatctc
    16321 gtcgcgtcac aacgccaagc aaagtttgat tgcttcgaac aactggtacc atttcaaagt
    16381 cttctgcgat catccgttga ctcacattgg caatatttgt cgataatcca accaaaaata
    16441 gactacgaga cataacctta tcaattgtcg tgcttggtga tttatcacca gcgtctctca
    16501 tggttacaac gccaacaacg acctgatgtt gattgataac agggaaacgg ctgctacgat
    16561 tcttacgaac caagtccaaa taatctttaa ctgtatctgt ctctctcaga aaaccatact
    16621 catgactagg gcgataaagt ttctcaactg tcagaatatc agtcttgatt tggacatttg
    16681 acaaggcttt attgatcatg gtcgcgacgg taaaggtatc atgcttactt cttagaacag
    16741 gaatcccttt ttgattggcc agtttaagca catcatcatg aacctgaaat ccccctgtaa
    16801 ccagaactgc attttcattt tccaaggcta gcaactgaat acgggttcgg tctccgacaa
    16861 tcaagagccc cccatcatga aggtaagaca agatattttg ttcagtcatg gcaccaattg
    16921 aaaacttact aaattctctc tctaaacctt cttgcccagc cagaacctca gaagaagtca
    16981 cttctgcaat ttcagcaaac gttaatctct ctatagcaac tttctgggat ttaacacgaa
    17041 ttgttccact tctaggacgg gtctccacaa ttccacggtt ttcagcttct ttaatagccc
    17101 gataggctgt tccatcacta actcctagat gattcgaaat gctacgaaca ctgacccttt
    17161 tacctactgg taattcctcc aaatagctta gaatttcctg atgcttactc attgaactct
    17221 ccttttacat accgaaattc aagataatcc cgcatttttc ttgtgtaacg atcacttccc
    17281 ttaaactgac ggaacaaact aaatccagac ttaagagcaa ctctttggct agcttcattt
    17341 tcaaggtggg taatgataga taattgtttt aagccaaatt cctcaaaaga aagctgacaa
    17401 atttttctaa caacctctgt cataaatcct tgcgaccaag catcttttct caaaaaatag
    17461 ccaagctcag cttctttttt gatttcatct aacttctcaa atttaataga accaatcatt
    17521 tgttgatttt tctggtcaca aattgcccac actcccaaag gggacttcat aaagtaattg
    17581 gccagtgcat attgactttc ttccagactt gcctgcgttg ggaaaataaa ttgaagattt
    17641 tctggatttg aagctatctc gcggaagtcc tgactatcac taaaaaagaa aggacgcaaa
    17701 tacaagcgat ccgtttcaaa aaaagaaaac attgctaatt tggtccaaat attcataaac
    17761 acctctacgg tttaatcctc aacaagtcta atatccgctc ctaaattacg taatttttcg
    17821 ataatatcag aataaccacg taagataaac tcgatattgg taatttcagt tttaccttca
    17881 gccataagcc cagcaatgac tagtgcagcc ccagctctta agtcggtcgc tttaatactg
    17941 gccccacgta aatcacgtcc acccgtgtac aaaatatgac catttgttgt cgaaatatcc
    18001 gcatccatct ttgctagttc aaaaacatga tttacacgtt tttcgtaaat cgtatcgaca
    18061 attgtaccac gaccattcgc tcttagtaaa agaggggtaa gcggttgttg caaatcagtt
    18121 gcaaagcctg ggtaaggagc tgtcttaata ttgattgctt tcaaattaga ctgttcctcg
    18181 acaaaaatgc tgtcttcaga tacagtcatt ctcactccca tttcttccaa cttagcaata
    18241 aacccttcca ggtgttcgta aagaacatta tttatacgaa ttcctttacc aactgcagca
    18301 gctaaagata tatatgttcc agcttcaatg cggtctggaa tcacctgatg acgtgtccca
    18361 tgtaatcttt caacaccatc aataatgatg atattagttc ctgccccacg gatatgggca
    18421 cccatattat tcaagagagt agctacatca ataatctcag gttcacgggc tgcattttca
    18481 ataatagtac gaccatttgc tttaaccgca gcaatcatcg tattaatcgt tgctcccaca
    18541 ctaaccgtat ccatgtaaat acttgcacca tgaagtcctg tatctttagc agataacttc
    18601 atgttatctc cctcgtagct agcagtggca cccatagctt caaacgcctt aaggtgtaag
    18661 tcaatcggac gaggaccaag atcacatcct cccggtagac caactgtcgc ttcaccaaaa
    18721 cggcctaaga ggctcccata aaaatagtaa gatgcacgaa gactgttaat tttaccataa
    18781 ggcattggaa tattttgaac acctcttgga tcaatctcca agacatcgtc ataacgctta
    18841 acagtagctc ccattaattc catgatttcg acaagactgg ctacatccga aatatctgga
    18901 acacaatcca aagtcaccac atcatcagcc aatataatag ctggaattaa ggccacaaca
    18961 ctatttttag caccactaat agtaatttca ccttgcagtg gtaatccacc attgataaca
    19021 atttttctca ttctaagttt tcaatactct ttcaagattt ctaataaggt cttcaaaata
    19081 aagtatatca taaatttatc cttttttcca tccttttcaa ttttattgga taaatcagag
    19141 ttgacgagtt agtaactgaa ttactaatac tcaatgaaaa tcaaagatca aactaggaaa
    19201 ctagccgcag gttgctcaaa acactgtttt gaggttgtag atggaactga cgtagtcagt
    19261 atcctacaca tacggcaagg cgatattgac gtgatttgaa gagattttcg aagagtataa
    19321 tctttctcga atcgctattg cccctttttt atcccctaaa actgagtagg atctaagact
    19381 agatctctta tctaagtatc ggaatacggc tgttcaacta aattttagca agaacttctc
    19441 cccttctctc agttcacaga agcgttttat acataccgtc cctatatttc atgaacaaga
    19501 cgttttcagg ctagcatcct atcagacaat ctattttaaa gataaccgtg actcaggatc
    19561 acttctatct gtcgttttct ctttatagtg atagacctca cgggataagt cgtacatctt
    19621 tcctcgtgta tacaagatat aaggacgtta aaaggttaca gtgaaaatag aaaatcttag
    19681 tacgaattca attactctcg tgatttacgc atataggtta cgactacctt tttggacttt
    19741 agagtttgag acccccttat ccgctatata cgccttacta tcacgttcct gttcgtaaag
    19801 ccacgatttc gctatccctt cctctgacga ttcttatttc cagcgtcaga cttaaaacgg
    19861 tctatcccca gaccgtttta atccactacc tcacgatagt cgggcttggg aatcgctatt
    19921 tgactcgccg agaactttga catcagatat actataacaa attgaaataa gaatcaaaca
    19981 atttaatttt gaaattcaaa tcaatttata acaatatttt agaagatatg ctgtgctatt
    20041 ccagattcag tttgctatac atgcctgtcg taccacaaaa tccggttcta taatatttgt
    20101 agtgggtaaa tcccctatag atattatgga gcctatttta
//
LOCUS       DAVHIZ010000032        19325 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.034, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000032 DAVHIZ010000000
VERSION     DAVHIZ010000032.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19325)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19325)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19325
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.034"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(1..309)
                     /locus_tag="VVO18_001315"
                     /pseudo
     CDS             complement(1..309)
                     /locus_tag="VVO18_001315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            434..892
                     /locus_tag="VVO18_001316"
     CDS             434..892
                     /locus_tag="VVO18_001316"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000186958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4231 domain-containing protein"
                     /protein_id="HEU5586472.1"
                     /translation="MTPEEMYLTERLDVQIAHFLKKSVQHRRRYKVLKITEIVAGFLI
                     AVFCAIPMPGDRYRLISVALSSLGLLCEGIINLYNAKENWISYQKTAQLLEKEKFLYQ
                     CQTEKYAGKTKAFALFVKTCEGLISEEINQWESIQSKEVAASADAPVKKE"
     gene            905..1513
                     /locus_tag="VVO18_001317"
     CDS             905..1513
                     /locus_tag="VVO18_001317"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000083609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586473.1"
                     /translation="MSQSSYLSPLLWLKKEADKEKMSATQCQIFFFYYQMFELLFARE
                     SDMKDLCLGTKGFYFSQLEKNLLSGVSRFLKNLEGKVTLKANQEVSARKALFLALTTS
                     QSDWQELAPVFDFYQTIGRLENPSLLSSQDRQHLMWIYQSALEKDYIVKVIGDKHFVL
                     KRQDATKLTARQTQTLEILSQSEDLVNPVYVTLGEKGVLLLD"
     gene            1584..1916
                     /locus_tag="VVO18_001318"
     CDS             1584..1916
                     /locus_tag="VVO18_001318"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586474.1"
                     /translation="MYICIDNSMTKNKELVKNQTFKPALLTRRLVKNFMIEEPDLARN
                     PFTRPTLIDLDKVFMLDNTVIPTSYLARRRRNVSEELYEEILDHLVQSRLISLNKSEF
                     MQLNPGTY"
     gene            1927..3342
                     /gene="ply"
                     /locus_tag="VVO18_001319"
     CDS             1927..3342
                     /gene="ply"
                     /locus_tag="VVO18_001319"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cholesterol-dependent cytolysin pneumolysin"
                     /protein_id="HEU5586475.1"
                     /translation="MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFV
                     VIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSID
                     LPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQ
                     LKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTV
                     TVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQT
                     EWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTS
                     FLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVL
                     TPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRK
                     RTISIWGTTLYPQVEDKVEND"
     gene            4223..4939
                     /locus_tag="VVO18_001320"
     CDS             4223..4939
                     /locus_tag="VVO18_001320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015604432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YebC/PmpR family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5586476.1"
                     /translation="MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKKGDPDPESN
                     SALKFVIDRAKQAQVPKHIIDKAIDKAKGNTDETFTEGRYEGFGPNGSMLIVDTLTSN
                     VNRTAANVRAAFGKNGGNMGASGSVSYLFDNKGVIVFGGEDADAVFEQLLEADVDVDD
                     VEAQEGTITVYTAPTDLHKAIVALRESGIEEFQVTELEMIPQSEVELSGEDLETFEKL
                     YSVLEDDEDVQKIYTNVDGF"
     gene            5063..5512
                     /locus_tag="VVO18_001321"
     CDS             5063..5512
                     /locus_tag="VVO18_001321"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="HEU5586477.1"
                     /translation="MDKPMLVFKRFGHQIHLMVQKEAKRCGIEFMGGPQGQVVHFLDN
                     REKNQDLVLIKDIEQELNITKSVASNLVKRIVQNGLVELEASPVDKRAKFVRLTDKAR
                     SQMQQVKAFFERIDKQLMEDIDEDELLIFEKVLGQLQAKYQGNRRRE"
     gene            5551..6372
                     /locus_tag="VVO18_001322"
     CDS             5551..6372
                     /locus_tag="VVO18_001322"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000601671.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586478.1"
                     /translation="MILLAILFTCFLVYLELEVPTYISKITDLLGSQETNLDELWQPA
                     SMMMGMSFLAFLSVVAVGFFASRVAASYISRLRSDIFNRVLDYSQTEIKKFSIPSLLT
                     RTTNDITQVQMLITMGLQVVTRGPIMAIWAIGKILGHSEYWLWAVLVVVIVNVLMTTV
                     LMTLAFPKQSLIQGLTDKLNSITRESLTGIRVVRAYNAEDYQNEKFAAVNDELTRLNL
                     FVNRLMAILNPIMMGISSGLSVAIYWIGAYVINDAAPIARLPLFSDMIIFMSYAM"
     gene            6379..7410
                     /locus_tag="VVO18_001323"
     CDS             6379..7410
                     /locus_tag="VVO18_001323"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000506433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5586479.1"
                     /translation="MGFLLMGALFIVFPRTMVSAKRINQVLDLHSSIQNPVQVQLTDE
                     NFKGQVEFKDVTFRYAANSEAVIEHVSFKAETGQTVAFIGSTGSGKSTLVNLIPRFYD
                     VSAGEILVDGVNVQDYDFSVTAHAGQRVAIVGPTGAGKTTIVNLLMKFYEIDKRSIRI
                     DGVDTKAMTRSEVHDAFSMVLQDTWLFEGTIRDNLIYNQIGISDERMMEASKAVGIHH
                     FIMTLPDGYDTILDDTVTLSVGQKQLLTIACALLKDASLLILDEATSSVDTRTEELIQ
                     KAMDRLMEGRTSFVIAHRLSIIRNADLILVMKDGNIIEQGNYEELMAQGGFYADLYNS
                     QFTEDEAEE"
     gene            7476..7838
                     /locus_tag="VVO18_001324"
     CDS             7476..7838
                     /locus_tag="VVO18_001324"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2200 family protein"
                     /protein_id="HEU5586480.1"
                     /translation="MSQKLYNMKFAAVYLALIAKVERKGGKAESVHQVTSWLTGYEVS
                     DVLACLDRDVTYGDFFLQAPYYVPERIAITGKICGVHIEEIDDPLMQEIRRLDKLVDW
                     LAKGKTSQQVLEKYEKHK"
     gene            7835..8338
                     /locus_tag="VVO18_001325"
     CDS             7835..8338
                     /locus_tag="VVO18_001325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800945.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphatase PAP2 family protein"
                     /protein_id="HEU5586481.1"
                     /translation="MKNYQEWYRNISSRLTSRPILLFLLRSFNRLMTVAMPLVYLILL
                     VTTYLQLGLGQQVGVYVLIPASGFVALSLFRKKINHPRPYETWDICPLLDKDSSGRSM
                     PSRHVFSATIISMACLHASLPIGLVCLIFSALLGLVRVLGGVHYPKDVLVGYACGLVW
                     GFLFFLF"
     gene            8452..8898
                     /locus_tag="VVO18_001326"
     CDS             8452..8898
                     /locus_tag="VVO18_001326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000776610.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586482.1"
                     /translation="MKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKAPRLTF
                     YKGTGEYYLDLSEILFFETEGSKIYAHNQKEAYEVRLKLYELESILPRYFNRVSKSTI
                     ANIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR"
     gene            8903..9577
                     /locus_tag="VVO18_001327"
     CDS             8903..9577
                     /locus_tag="VVO18_001327"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000725744.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586483.1"
                     /translation="MKKKAFGIVFLVLAALILVQGNFGIPSLGGHIWPLIGIAFFAYQ
                     SVGALLRRHLTSASFTALVALMIANHFYGILPIPNQTLIWAGVLIVLGVNMLTHSNRT
                     WNGKKWWYDGEKNILIDKEVAFGTGTFYKQDQELVEDQVEVGFGNAKIYYDNAEMLGD
                     FATLNIEVAFGNATVYVPQHWCVDLKVETSFGAAKADAPVAPTSKTLIIRGDVAFGKL
                     ELVYVK"
     gene            9829..10017
                     /locus_tag="VVO18_001328"
                     /pseudo
     CDS             9829..10017
                     /locus_tag="VVO18_001328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647592.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein A"
     gene            10267..10566
                     /locus_tag="VVO18_001329"
     CDS             10267..10566
                     /locus_tag="VVO18_001329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4651 domain-containing protein"
                     /protein_id="HEU5586484.1"
                     /translation="MNGMKAKKMWMAGLALLGIGSLALATKKVADDHKLMKTQEELTA
                     IVRDHFSDMGEIATLYVQVYESSLESLVGGVIFEDGRHYTFVYENEDLVYEEEVL"
     gene            10563..10880
                     /locus_tag="VVO18_001330"
     CDS             10563..10880
                     /locus_tag="VVO18_001330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000615765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin family protein"
                     /protein_id="HEU5586485.1"
                     /translation="MIQPASLEELASLVEKAGKKVFLFVADWCGDCRYIYPALPEIEE
                     TNPEFTFIRMDRDQYMDLAKLWDVYGIPSLVVLEKDKEIGRFVNRDRKSKEQINDFLA
                     GLK"
     gene            10896..11522
                     /locus_tag="VVO18_001331"
     CDS             10896..11522
                     /locus_tag="VVO18_001331"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4479 and tRNA-binding domain-containing
                     protein"
                     /protein_id="HEU5586486.1"
                     /translation="MIFTYNKEHVGDVLMVIVKNSGDAKLNVERKGKVARVFLKENGE
                     TVAWNIFEVSSLFEIAERGQVFLSDEQVARLNQELQAEGFTEEIVNDKEPKFVVGEIV
                     EMVAHPDSDHLNICQVAVASDKIVQIVAGAPNARVGLKTIVALPGAMMPKGNFIFPGE
                     LRGEKSFGMMCSPRELHLPNAPQKRGVLELSEDQVVGTPFDPAKHWTA"
     gene            11555..12316
                     /locus_tag="VVO18_001332"
     CDS             11555..12316
                     /locus_tag="VVO18_001332"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="HEU5586487.1"
                     /translation="MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEILKS
                     EFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYE
                     ELDMLTMLDTNVKGLMAVTRCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAA
                     VKTFSDGLRIDTIATDIKVTTIQPGIVETDFSTVRFHGDKERAASVYQGIETLQAQDI
                     ADTVVYVTSQPRRVQITDMTIMANQQATGFMVHKK"
     gene            12394..12789
                     /locus_tag="VVO18_001333"
     CDS             12394..12789
                     /locus_tag="VVO18_001333"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282444.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="HEU5586488.1"
                     /translation="MYNKVILIGRLTSTPELHKTNNDKSVARATIAVNRRYKDQNGER
                     EADFVNMVLWGRLAETLASYATKGSLISVDGELRTRRFEKNGQMNYVTEVLVTGFQLL
                     ESRAQRAMRENNAGQDLADLVLEEEELPF"
     gene            12945..13229
                     /gene="groES"
                     /locus_tag="VVO18_001334"
     CDS             12945..13229
                     /gene="groES"
                     /locus_tag="VVO18_001334"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="co-chaperone GroES"
                     /protein_id="HEU5586489.1"
                     /translation="MLKPLGDRVVLKVEEKEQTVGGFVLAGSAQEKTKTAQVVATGQG
                     VRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE"
     gene            13245..14867
                     /gene="groL"
                     /locus_tag="VVO18_001335"
     CDS             13245..14867
                     /gene="groL"
                     /locus_tag="VVO18_001335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018166362.1"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES;
                     misfolded proteins enter the barrel where they are
                     refolded when GroES binds; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chaperonin GroEL"
                     /protein_id="HEU5586490.1"
                     /translation="MSKEIKFSSDARSAMVRGVDILADTVKVTLGPKGRNVVLEKSFG
                     SPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREG
                     IKNVTAGANPIGIRRGIETAVAAAVEALKNNAIPVANKEAIAQVAAVSSRSEKVGEYI
                     SEAMEKVGKDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDSEKMVADLENPYI
                     LITDKKISNIQEILPLLESILQSNRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKA
                     PGFGDRRKAMLEDIAILTGGTVITEDLGLELKDATIEALGQAARVTVDKDSTVIVEGA
                     GNPEAISHRVAVIKSQIETTTSEFDREKLQERLAKLSGGVAVIKVGAATETELKEMKL
                     RIEDALNATRAAVEEGIVAGGGTALANVIPAVATLELTGDEATGRNIVLRALEEPVRQ
                     IAHNAGFEGSIVIDRLKNAELGIGFNAATGEWVNMIDQGIIDPVKVSRSALQNAASVA
                     SLILTTEAVVANKPEPVAPAPAMDPSMMGGMM"
     gene            15005..15760
                     /locus_tag="VVO18_001336"
                     /pseudo
     CDS             15005..15760
                     /locus_tag="VVO18_001336"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000567550.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="epoxyqueuosine reductase QueH"
     gene            complement(16198..16731)
                     /locus_tag="VVO18_001337"
     CDS             complement(16198..16731)
                     /locus_tag="VVO18_001337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000775318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF402 domain-containing protein"
                     /protein_id="HEU5586491.1"
                     /translation="MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDH
                     TLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYI
                     DYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFS
                     EAYVNIWYKRYVELKNR"
     gene            complement(16820..17596)
                     /gene="recX"
                     /locus_tag="VVO18_001338"
     CDS             complement(16820..17596)
                     /gene="recX"
                     /locus_tag="VVO18_001338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000705102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombination regulator RecX"
                     /protein_id="HEU5586492.1"
                     /translation="MKITKLEKKKRLYLMELDNGDKCYITEDTIVRFMLSRDKVISEE
                     ELKEIQDFAQFSYGKNLALYHLSFKARTEKEVREYLKKYDIDKNIVSQVIANLKEDKW
                     INDGQYAYAIINTNQLSGDKGPYVLTQKLAQKGISKSTIEENLKEFDFSEVAQRVANK
                     LLKKYEGKLPARALQDKIIQNLTNKGFSYSDAKIAFDDLDSQVDQETTQELIFKELDK
                     QYTKYARKYEGYELKQRLTQVLARKGYDFSDIASALREYL"
     gene            17634..18989
                     /gene="rlmD"
                     /locus_tag="VVO18_001339"
     CDS             17634..18989
                     /gene="rlmD"
                     /locus_tag="VVO18_001339"
                     /EC_number="2.1.1.190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA (uracil(1939)-C(5))-methyltransferase
                     RlmD"
                     /protein_id="HEU5586493.1"
                     /translation="MNLKVKQKIPLKIKRMGINGEGIGFYQKTLVFVPGALKGEDIYC
                     QITSIRRNFVEAKLLKVNKKSKFRIVPSCTIYNECGGCQIMHLHYDKQLEFKTDLLHQ
                     ALKKFAPAGYENYEIRPTIGMQEPKYYRAKLQFQTRKFKNQVKAGLYAQNSHYLVELK
                     DCLVQDKETQVIANRLAELLTYHQIPITDERKVLGVRTIMVRRARKTGQVQIIIVTNR
                     QLNLTQLVKELVKDFPEVVTVAVNTNTAKTSEIYGEKTEIIWGQESIQEGVLNYEFSL
                     SPRAFYQLNPEQTEVLYSEAVKALDVDKEDHLIDAYCGVGTIGFAFAKKVKTLRGMDI
                     IPEAIEDAKRNAKRMGFDNTHYEAGTAEEIIPRWYKEGYRADALIIDPPRTGLDDKLL
                     DTILTYVPEKMVYISCNVSTLARDLVRLVEVYDLHYIQSVDMFPHTARTEAVVKLIKK
                     V"
     gene            19051..19122
                     /locus_tag="VVO18_001340"
     tRNA            19051..19122
                     /locus_tag="VVO18_001340"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:19084..19086,aa:Glu,seq:ttc)
BASE COUNT         5860 a         3487 c         4288 g         5690 t
ORIGIN      
        1 attttaaacg tttttacttt ggtaaagatg ttctcaacct tgcttctctc cttagatagc
       61 gcatggttac aggatttatc ttcaactgtt agcggcttga gtttgctgga tttacgtgga
      121 gtttgtgctt gaggatatat cttcatgagc ccttgataac cactgtcagc caagatttta
      181 ccagcttgtc tgactttttt gataagctgt ttttaataca gctaacatct cttcaaaagt
      241 ggtacgctga acaccaacaa gacgcttaaa tcgtgcatca gttagttgtt tacttgcttc
      301 ataattcata gaactactat accatatttt gtttcgcagg aagtctaata agttatagtc
      361 cagtttttac tatactttga tattcaaata tgttatacta tggttatcaa agtaaatgaa
      421 aggagttacg aatatgacgc cagaagaaat gtacctgaca gagcgattag acgtacagat
      481 agctcatttt ttaaagaaaa gcgttcaaca tcgtaggcgc tataaggtat taaaaataac
      541 agaaatcgtg gcaggtttcc tcatagctgt cttttgtgct attcctatgc caggtgatcg
      601 ctaccgtttg atttcggttg ccttatccag tctcggcttg ctgtgtgagg ggattatcaa
      661 tttgtataat gcaaaggaaa attggatttc ttaccaaaaa actgcgcaac tcctggagaa
      721 agaaaaattc ctctatcaat gccaaacgga gaaatatgca ggaaagacca aggcttttgc
      781 cctatttgtc aagacatgcg aaggtcttat ctcagaggag attaaccagt gggaaagtat
      841 ccagtcaaaa gaagtggcag ctagtgcaga tgctccagtt aaaaaagagt aggaggtaga
      901 ggaaatgtct caatccagct acctgtcgcc cttgctctgg ttaaaaaaag aagccgataa
      961 ggaaaagatg agcgcgaccc agtgccagat atttttcttt tactatcaaa tgtttgagct
     1021 cttatttgct agagaaagcg acatgaaaga cttatgtctg ggaacgaaag gtttttattt
     1081 ctcgcagtta gagaaaaatt tgctttctgg agtttcccga tttctaaaaa acttggaggg
     1141 gaaagtaact ctcaaggcta accaagaagt atcagctcgc aaagcccttt ttctagcctt
     1201 gacaactagc caatcagatt ggcaggagtt agctcctgtt tttgattttt atcagactat
     1261 cgggaggctt gaaaatcctt ctctcttgag ttctcaggac agacaacatc tgatgtggat
     1321 ttaccagtca gctttggaga aggattatat tgtcaaggtt attggtgaca agcattttgt
     1381 attgaagaga caagatgcta ctaaattgac agcgcgccaa actcaaactt tggaaattct
     1441 gagtcaatca gaagacttgg tcaatcctgt ctatgttaca ttaggagaaa agggggtgct
     1501 cttgcttgat taagagagga gatgttgtag ttctttattt gccttttccg actattagta
     1561 gcgatttggc tgtgaagaat catatgtata tctgtattga caacagcatg actaaaaaca
     1621 aagagttggt taaaaatcag accttcaaac cagctctctt gaccagacgt ttggtcaaga
     1681 actttatgat agaagagccg gatctagctc gtaatccttt tacaagacca accttgattg
     1741 acttagataa ggtatttatg ttggataata cggttattcc gacttcttat ctagccagac
     1801 ggcgacgcaa tgtctcagaa gaattgtacg aggaaatttt ggatcactta gtccaatcac
     1861 ggctgatttc gctgaacaag tctgagttta tgcaactcaa tccaggaact tattaggagg
     1921 tagaagatgg caaataaagc agtaaatgac tttatactag ctatgaatta cgataaaaag
     1981 aaactcttga cccatcaggg agaaagtatt gaaaatcgtt tcatcaaaga gggtaatcag
     2041 ctacccgatg agtttgttgt tatcgaaaga aagaagcgga gcttgtcgac aaatacaagt
     2101 gatatttctg taacagctac caacgacagt cgcctctatc ctggagcact tctcgtagtg
     2161 gatgagacct tgttagagaa taatcccact cttcttgcgg tcgatcgtgc tccgatgact
     2221 tatagtattg atttgcctgg tttggcaagt agcgatagct ttctccaagt ggaagacccc
     2281 agcaattcaa gtgttcgcgg agcggtaaac gatttgttgg ctaagtggca tcaagattat
     2341 ggtcaggtca ataatgtccc agctagaatg cagtatgaaa aaatcacggc tcacagcatg
     2401 gaacaactca aggtcaagtt tggttctgac tttgaaaaga cagggaattc tcttgatatt
     2461 gattttaact ctgtccattc aggcgaaaag cagattcaga ttgttaattt taagcagatt
     2521 tattatacag tcagcgtaga cgctgttaaa aatccaggag atgtgtttca agatactgta
     2581 acggtagagg atttaaaaca gagaggaatt tctgcagagc gtcctttggt ctatatttcg
     2641 agtgttgctt atgggcgcca agtctatctc aagttggaaa ccacgagtaa gagtgatgaa
     2701 gtagaggctg cttttgaagc tttgataaaa ggagtcaagg tagctcctca gacagagtgg
     2761 aagcagattt tggacaatac agaagtgaag gcggttattt tagggggcga cccaagttcg
     2821 ggtgcccgag ttgtaacagg caaggtggat atggtagagg acttgattca agaaggcagt
     2881 cgctttacag cagatcatcc aggcttgccg atttcctata caacttcttt tttacgtgac
     2941 aatgtagttg cgacctttca aaatagtaca gactatgttg agactaaggt tacagcttac
     3001 agaaacggag atttactgct ggatcatagt ggtgcctatg ttgcccaata ttatattact
     3061 tggaatgaat tatcctatga tcatcaaggt aaggaagtct tgactcctaa ggcttgggac
     3121 agaaatgggc aggatttaac ggctcacttt accactagta ttcctttaaa agggaatgtt
     3181 cgtaatctct ctgtcaaaat tagagagtgt accgggcttg cctgggaatg gtggcgtacg
     3241 gtttatgaaa aaaccgattt gccactagtg cgtaagcgga cgatttctat ttggggaaca
     3301 actctctatc ctcaggtaga agataaggta gaaaatgact aggagaggag aatgcttgcg
     3361 acaaaaagag gcgatgatct ctctgcagat atctgaaagt ttatctcttg cctagcgatt
     3421 tccattggag tatgctcgtg atgttaaaat gaatctatca aacagaatgt gtaaaaaagt
     3481 aaaaagggta gccaattctt tgatatacag gggattgatt atcctttact tgttttagat
     3541 gattggaaat tcaagaacga cacgtatcgg aaatattttg ctgtttatat ctaataccca
     3601 tttatggaaa aaatgaaatt aaatatgaac aaatcaattg ctagcaatgg tttagaagtg
     3661 ccagtgtact agtctaactt ctccatcttg ggaacacgta aattatactc ttcgaaaatc
     3721 tcttcaaacc atgtcagccc catccgcaac ctcaaaacag tgttttgagc aacctgaggc
     3781 tagctttcta gtttgctctt tgatttttat tgagtattag aggtttgctt agaaactctt
     3841 ctattgattt cttagaatac aatagcgcct ataagaactg ttgaatttca aagtatttac
     3901 ttgaactatg atatgtctgg agtagactgt caacaaaagg tgcagtatga ttgtttttgt
     3961 cgcttatatc tacaaacttc aaacagtaat ttgagctgac tttgtcaaac ttggctgaaa
     4021 ctttctattt gcagataatg gtctagtttg ttttttgaat gtggatgagt gtctgttgat
     4081 aaagatagaa aggcaagacc atcttagcag gtaaagtgct atcctagctt gatttgctaa
     4141 taaaatccat ttcctctagt gaaaatcaaa aaaacttgtg ttataataag aaagattaaa
     4201 atgtgaaaaa aggagattcc taatgggacg taaatgggcc aatatcgtag ccaagaaaac
     4261 ggctaaagat ggagctaact ctaaagtata tgcaaaattt ggtgtagaaa tctatgtagc
     4321 agctaaaaaa ggtgatccag atccagaatc aaactcagct ttgaaattcg ttatcgaccg
     4381 tgctaaacaa gcccaagtgc caaaacacat tatcgataaa gcgattgata aagccaaagg
     4441 aaacacagac gaaaccttta cagaaggacg ttacgaaggt tttgggccaa atggctctat
     4501 gctaattgtg gatactttga cttctaacgt taaccgtaca gcagccaatg tccgtgcagc
     4561 ctttggtaaa aacggcggaa acatgggcgc ttcaggttct gtttcttacc tctttgacaa
     4621 caaaggtgtt attgtatttg gaggtgaaga tgcagacgca gtctttgagc aattgctcga
     4681 agcggatgta gatgtggatg acgtagaagc acaagaaggt acaatcacag tttacacagc
     4741 gccaactgac cttcacaagg ctatcgttgc cctccgtgag tctggtattg aagagttcca
     4801 agtgactgaa ttggaaatga ttcctcagtc agaagtggaa ttgtcaggcg aagaccttga
     4861 aacctttgaa aaactttaca gcgttcttga agacgacgaa gacgtccaaa agatttatac
     4921 gaacgtagat gggttttaat ttaacctata gaacatgatc ctaagtgaga aaatcacttg
     4981 ggattttttt aatcaagaaa atagttctca tagaaattta attattctcc agagaactat
     5041 ttttatttag aagggggaga ttatggataa accgatgtta gtctttaagc gttttggtca
     5101 tcaaattcac ctgatggtgc aaaaggaagc caaacgttgc ggcattgaat ttatgggtgg
     5161 gccgcaaggt caggttgtgc attttttgga taatcgcgag aaaaaccaag acttggtctt
     5221 gattaaagat atcgagcagg aactcaatat taccaagtct gttgctagta atctggttaa
     5281 gcgtatagtg caaaatggtt tggtggaatt ggaggcgagt cctgttgata agcgggctaa
     5341 gtttgttcgt ctgacggaca aagcacgttc tcagatgcaa caggttaagg ctttttttga
     5401 acgcatagac aagcagttga tggaagacat tgatgaagat gaattactga tttttgagaa
     5461 ggttctcggt caactacagg caaaatatca agggaatagg aggagagaat aaagaaatta
     5521 gccaaaagaa ttagtagaaa agaatggggg atgattttac tagccattct ctttacttgc
     5581 tttttggtct atctagagtt ggaagtgccg acctatatct cgaaaattac ggatttgcta
     5641 ggtagtcaag aaactaattt agatgagttg tggcagccgg caagcatgat gatgggaatg
     5701 tcctttcttg ccttcttgtc cgtagttgca gttggatttt ttgcatcccg agtggcggct
     5761 tcttatatta gtaggctgag aagtgatatt tttaaccgag ttttggatta ctcgcagaca
     5821 gagattaaga aattttcaat tcctagcctc ttgacgcgta ctaccaatga cattactcaa
     5881 gttcaaatgt tgattactat gggcttgcaa gtggtaacgc gtggtccaat tatggctatc
     5941 tgggctattg ggaagatttt aggtcattca gaatactggc tctgggccgt acttgtggta
     6001 gtgattgtca acgtcctgat gacgaccgtt ttgatgacgc tagcctttcc aaaacagtcc
     6061 ttgattcagg ggttgacaga taaactgaac agtatcactc gtgagagttt aacaggtatt
     6121 cgtgtcgttc gtgcctacaa tgcagaggat tatcaaaatg aaaaatttgc agcagtaaat
     6181 gatgaattga cccgtttgaa tttgtttgtc aaccgtctta tggctatttt gaatcctatc
     6241 atgatgggga tttcaagtgg tttgagtgta gcgatttact ggattggggc ctatgtgatt
     6301 aacgacgctg ctccgatagc gcgtctgcct ctctttagtg acatgattat tttcatgtct
     6361 tatgccatgt aggttgtcat gggcttcctt ctcatgggag cactcttcat cgtttttccc
     6421 cgaactatgg tctctgctaa gcggattaat caagttttag atttgcattc ttctatccaa
     6481 aaccctgttc aagtgcagct gactgatgaa aacttcaaag gtcaggtcga gtttaaggat
     6541 gtgaccttcc gctatgcggc aaattcggag gcagttattg aacatgttag ctttaaagca
     6601 gaaactggtc aaacagtggc ctttattggg tcaacaggtt ctggtaaatc aactctggtc
     6661 aatctgattc cacgtttcta cgacgtgtca gcaggagaaa ttctggtgga cggtgtcaat
     6721 gttcaagact atgacttctc tgtgacagct catgctggtc aaagggttgc cattgttggg
     6781 ccgactgggg ctggtaagac aaccattgtc aatcttttga tgaaattcta tgagattgat
     6841 aagagaagta ttcgcattga tggtgtggat accaaggcta tgacgcgttc agaagtgcat
     6901 gatgcctttt caatggtctt gcaggatacc tggctctttg aaggaactat tcgagacaat
     6961 ctcatctata atcaaatagg gattagtgat gaacgaatga tggaagctag taaggctgtg
     7021 ggaattcacc actttattat gaccttgcca gatggctatg ataccatctt ggatgacacc
     7081 gtgaccttgt ctgtaggaca aaaacaacta ttgactattg cttgtgccct tcttaaggat
     7141 gcatcgcttt tgattttgga tgaggcgact tcttctgttg acacacggac agaggaattg
     7201 atccaaaaag ccatggaccg tttgatggaa ggacgcacat cctttgtcat tgcccaccgc
     7261 ttgtcaatca tccgaaatgc agacttgatc ttggtcatga aagatggaaa tatcatcgag
     7321 caaggcaact atgaggaact gatggcgcaa ggtggcttct acgctgactt gtacaatagt
     7381 caatttacag aagatgaagc agaagaataa atcaaaaaaa ggcttgacgg ccttcttttt
     7441 cttatttata ctagtacaca tagaaagaga gaagtatgag tcagaaatta tacaatatga
     7501 aatttgctgc tgtctactta gccttgattg caaaagttga gcgaaagggt ggaaaggcag
     7561 agtcagttca ccaagtgacc agttggttga cagggtatga agtgagtgac gttcttgctt
     7621 gtctggatag ggatgttact tacggagatt tttttctaca agcaccatat tatgtccctg
     7681 aacgaattgc aattacaggg aagatttgcg gtgtccatat tgaggaaatt gatgatcctc
     7741 tgatgcagga aatacgtcgt ttggacaagc tagtggattg gcttgccaag gggaaaacat
     7801 ctcaacaagt tctagaaaag tatgagaagc ataaatgaaa aattatcaag aatggtatcg
     7861 aaatatcagc tccagactaa ctagtcgtcc aattctttta ttcctattac gcagtttcaa
     7921 tcgtttgatg acagtcgcca tgcccctggt ctatctgatc ttgctagtca ccacttacct
     7981 gcaactagga cttggtcagc aagttggggt ttatgtgctt attcctgcat caggttttgt
     8041 ggccttgtcc ctgtttcgta agaaaatcaa tcacccgaga ccttatgaaa cttgggatat
     8101 ctgtcccctt cttgataagg atagttcggg acggtcgatg cccagtcgcc atgtcttttc
     8161 tgcaactatc atctccatgg cctgtctgca tgctagtcta cctattggct tagtatgctt
     8221 gatcttttca gctttgctgg ggttggtgag ggttttaggg ggtgttcatt atcccaagga
     8281 tgtcttggtt ggctatgctt gtggtctggt gtggggattc cttttcttcc tattctgaca
     8341 tgtaagttaa gctagtccta caaccactta ctgcttcaaa ttgaccactt gcttttttgc
     8401 ccttgtattc ctaacttagc tttgatatag tagagtcaga aaggagatgt gatgaagtta
     8461 cgaattgaga ttgacggcaa tttagaggag actgaaattg tcatcaagac ccccactttg
     8521 acagatgaaa ttgcagactt gcaacggctc ttgcaagagt caaaggctcc gaggttgact
     8581 ttttacaagg ggacaggtga atattatcta gacctgtcag aaattctctt ctttgaaaca
     8641 gaagggagca agatctacgc tcataaccag aaggaagctt atgaggttcg cctcaagctc
     8701 tatgagttgg agtctatctt gcctcgctat tttaatcgag tttccaagtc aacgatcgca
     8761 aacatccgtc agatttactc agtggacaag tccttttcag gaacgggcac catttccttt
     8821 tatcagacgc acaaggaggt tcatgtctca cggcattacc aatccctcct aaaagaaaat
     8881 ctaagaaaca tgaggtaata agatgaaaaa gaaagcattt ggtattgtgt tccttgtact
     8941 agcagcttta atattagtac aaggaaattt tggaatccct tctctaggag ggcacatttg
     9001 gcccttgatt ggtattgctt tttttgccta ccaatcagtt ggagctttgt tgcgtcgcca
     9061 cttaacttca gcctctttta cagctctagt agccttaatg attgctaacc acttttatgg
     9121 cattttaccg attccaaacc agacactaat ctgggcagga gttctaatcg ttctcggagt
     9181 aaatatgttg actcattcta acagaacttg gaatgggaaa aaatggtggt atgatggtga
     9241 aaaaaacatt cttatagata aggaagttgc ttttgggaca gggactttct acaagcaaga
     9301 ccaagaattg gtagaagacc aagtagaagt tggttttggc aatgcaaaaa tctactatga
     9361 caatgcagag atgttaggtg attttgcaac tttaaatatt gaagtagctt ttggtaatgc
     9421 aactgtctat gttccgcaac actggtgtgt cgatttgaaa gtagaaacat cctttggtgc
     9481 agccaaggcg gacgctcctg tagcgccaac aagcaaaacc ttgattattc gtggagacgt
     9541 ggcctttggg aagttggagc ttgtctacgt taaataaaaa aatcttcact taaaccatca
     9601 aaatagacgt actaagagta ggaaattgat gccttgctct gatttcagtt ctatggttgt
     9661 tagactttaa aaaatgaaat gttgccttta aaagttgtat atttttcgat attttggctc
     9721 ttacgtttga tgtatctatg tcctacagcg tggatgatgt agtgtaaaat gctttaaaaa
     9781 aatgaatgat attggacagt tttttgaacc tttaattgct caggagccat gaaagcaagc
     9841 acttgagttt atgacaaggg agaatggtat tatgtaagtt cttctggagc catgctagcg
     9901 aatgattggg tcaaagataa tggcaagtgg tattatctag cttcatcagg taagatgctt
     9961 cgcaatacct acacacctga tggttactac gttggtaact caggcgcctg gcaataagaa
    10021 taatactctt cgaaaatctc ttcaaaccac gtcagcttca tccacaacct caaaacagtg
    10081 ttttgagctg acttcgtcag ttctatctac aacctcaaag cagtgctttg agcagcctgc
    10141 ggctagcttc ctagtttggt ctttgatttt cattgagtat aagaagccct tttccttaaa
    10201 ggaagaggct ttttacttgc ttttttgctg tttcctcatt tgtcctaaag ccttttttgt
    10261 gttaaaatga atggtatgaa agctaaaaaa atgtggatgg caggtctggc tctgcttggt
    10321 attgggagcc ttgcccttgc tacgaaaaaa gttgcagatg atcataagct catgaagact
    10381 caggaagagt tgacagcgat tgtacgagac catttttccg acatggggga aattgcgacc
    10441 ctttatgttc aagtttacga aagcagtctg gagagcttgg ttggtggcgt catttttgag
    10501 gatggccgtc attatacctt tgtctatgaa aatgaagacc tagtctatga ggaggaagtc
    10561 ttatgataca gccagcaagt ttagaagaat tagcatcttt agtggaaaaa gcgggcaaga
    10621 aggtcttcct ttttgtggca gactggtgtg gcgattgtcg ttatatttat cctgccttac
    10681 cagagattga agagaccaat ccagagttca cctttattcg aatggaccga gatcagtata
    10741 tggatttggc caaactctgg gatgtttacg gaattcctag ccttgttgtt ctagaaaagg
    10801 acaaggaaat cggtcgtttt gtcaatcgcg accgtaaaag taaggagcaa attaacgatt
    10861 ttttagcagg attgaaatag gagaaaaagg aaacaatgat ttttacgtat aacaaagaac
    10921 atgtcggtga tgtccttatg gtcatcgtga aaaatagcgg agatgccaaa ctgaatgtgg
    10981 aacgcaaagg caaggtagcc cgtgttttcc tcaaagaaaa tggggaaaca gtagcttgga
    11041 acatttttga ggtttcgagc ttgtttgaaa ttgcagagcg cggtcaagtc tttttatcag
    11101 atgagcaagt cgctcgtttg aaccaagaat tacaggcgga aggttttaca gaagaaattg
    11161 ttaatgataa ggaacctaag tttgttgttg gtgaaattgt cgagatggta gctcatccag
    11221 acagtgacca cctcaacatc tgccaagttg cagtcgcaag tgacaagata gtgcaaatcg
    11281 ttgcaggagc acctaatgcg cgtgttgggt tgaaaaccat tgtggctctt cctggtgcca
    11341 tgatgccaaa agggaatttc attttcccag gcgaacttcg tggtgaaaag agttttggga
    11401 tgatgtgtag tcctcgtgaa ttgcatttgc caaatgctcc gcaaaaacgt ggggtgcttg
    11461 aattatcaga agaccaagtt gtcggaacac cgttcgaccc agcgaaacac tggactgcct
    11521 aggaacttgt cagcatctga tagaaggaaa taagatggca aaaaatgtag tgattacggg
    11581 agcaacctca ggaatcggtg aagcgattgc gcgtgcttat ctggagcagg gtgaggatgt
    11641 cgttctaaca ggacgacgga tagacagatt agaaatcctc aagtcggagt ttgcagtaag
    11701 ctttccaaat caaaccgtct ggacttttcc actagatgtg acggatatgg tcatggtgaa
    11761 gactgtttgc tctgatattc tagaaacgat agggaggatt gatatcttgg tcaacaacgc
    11821 cggactggct cttgacttgg ctccctatca agactatgag gagttggata tgttgaccat
    11881 gttggatacc aatgttaaag gtctgatggc ggttactcgc tgtttcttgc cagcaatgat
    11941 aaaagtcaat caaggtcata ttatcaatat ggggtcaacc gcaggaatct acgcctatgc
    12001 tggtgccgct gtttactcag ctaccaaggc agcggttaag accttttcgg atggactgcg
    12061 aattgatacc atcgcaacgg atatcaaggt gacgaccatt cagcctggaa ttgtcgaaac
    12121 agatttttct acagtgcgtt ttcatggtga taaagaacga gctgcgtccg tttaccaagg
    12181 aatagaaact ttgcaagctc aggatattgc agatacagta gtctatgtga ctagtcaacc
    12241 tcgtcgtgtt cagattacag atatgaccat tatggccaat caacaggcga caggtttcat
    12301 ggttcataaa aaataaaaaa ttttctcgaa aagttacaaa tttctgtaac tttttttgat
    12361 ttcctacgaa tagataagta ggaggaagaa aatatgtata ataaagttat cttgattgga
    12421 cgtttaacgt ctacaccaga attgcacaaa accaacaatg acaagtcagt agcgcgagca
    12481 actatcgctg tcaaccgtcg ttacaaagac caaaacggtg aacgtgaagc tgattttgtc
    12541 aatatggttc tatggggcag actagcagaa actttggcaa gctacgcaac caaaggtagt
    12601 ctcatttccg ttgatggaga attgcgtacc cgtcgctttg agaaaaatgg tcagatgaat
    12661 tatgtaaccg aagtccttgt gacaggattc caactcttgg aaagtcgtgc ccaacgtgct
    12721 atgcgtgaaa ataatgcagg ccaagatttg gcagatttgg tcttggaaga ggaagaattg
    12781 ccattttaag aattaaaaag tctgagttgg tctcaggctt tttatcttga gaaagtcaga
    12841 cttttttctt gattatttct gactaagtga tacaatagaa ctatgaatta gcactcaggt
    12901 ataaagagtg ctaataatat ctatctcatt atggaggaaa tcagatgttg aaaccattag
    12961 gggaccgtgt ggtcttaaaa gtagaagaaa aagaacaaac tgttggaggc tttgttctcg
    13021 caggttcagc ccaagaaaaa accaaaacag cccaagttgt ggctactgga caaggtgttc
    13081 gtaccttgaa cggtgacttg gttgctccaa gtgttaaaac tggagatcgt gtcttagttg
    13141 aagcccacgc aggtcttgat gtcaaagatg gcgatgaaaa gtacatcatc gtaggcgaag
    13201 ctaacatttt ggcaatcatt gaggaataga aggagaaagt aagtatgtca aaagaaatta
    13261 aattttcatc agatgcccgt tcagccatgg ttcgtggtgt cgatatcctt gcagacactg
    13321 ttaaagtaac cttgggacca aaaggtcgca atgtcgttct tgaaaagtca ttcggttcac
    13381 ccttgattac caatgacggt gtgaccattg ccaaagaaat cgaattggaa gaccattttg
    13441 aaaatatggg tgctaagtta gtatcagaag tagcttctaa aaccaatgat atcgcaggtg
    13501 acggaactac gactgcaaca gtcttgaccc aagctatcgt ccgtgaagga atcaaaaacg
    13561 tcacagcagg tgcaaatcca atcggtattc gtcgtgggat tgaaacagca gttgccgcag
    13621 cagttgaagc tttgaaaaac aacgccatcc ctgttgccaa taaagaagct atcgctcaag
    13681 ttgcagccgt atcttctcgt tctgaaaaag ttggtgagta catctctgaa gcaatggaaa
    13741 aagttggcaa agacggtgtc atcaccatcg aagagtcacg tggtatggaa acagagcttg
    13801 aagtcgtaga aggaatgcag tttgaccgtg gttacctttc acagtacatg gtgacagata
    13861 gcgaaaaaat ggtggctgac cttgaaaatc cgtacatttt gattacagac aagaaaattt
    13921 ccaatatcca agaaatcttg ccacttttgg aaagcattct ccaaagcaat cgtccactct
    13981 tgattattgc ggatgatgtg gatggtgagg ctcttccaac tcttgttttg aacaagattc
    14041 gtggaacctt caacgtagta gcagtcaagg cacctggttt tggtgaccgt cgcaaagcca
    14101 tgcttgaaga tatcgccatc ttaacaggcg gaacagttat cacagaagac cttggtcttg
    14161 agttgaaaga tgcgacaatt gaagctcttg gtcaagcagc gagagtgacc gtggacaaag
    14221 atagcacggt tattgtagaa ggtgcaggaa atcctgaagc gatttctcac cgtgttgcgg
    14281 ttatcaagtc tcaaatcgaa actacaactt ctgaatttga ccgtgaaaaa ttgcaagaac
    14341 gcttggccaa attgtcaggt ggtgtagcgg ttattaaggt cggagccgca actgaaactg
    14401 agttgaaaga aatgaaactc cgcattgaag atgccctcaa cgctactcgt gcagctgttg
    14461 aagaaggtat tgttgcaggt ggtggaacag ctcttgccaa tgtgattcca gctgttgcta
    14521 ccttggaatt gacaggagat gaagcaacag gacgtaatat tgttctccgt gctttggaag
    14581 aacccgttcg tcaaattgct cacaatgcag gatttgaagg atctatcgtt atcgatcgtt
    14641 tgaaaaatgc tgagcttggt ataggattta acgcagcaac tggcgagtgg gttaacatga
    14701 ttgatcaagg tatcattgat ccagttaaag tgagtcgttc agccctacaa aatgcagcat
    14761 ctgtagccag cttgattttg acaacagaag cagtcgtagc caataaacca gaaccagtag
    14821 ccccagctcc agcaatggat ccaagcatga tgggcgggat gatgtaagca ttctatagaa
    14881 aacaacttat aaaaaacaca aaaggaggga atgactaacc cttcttttta taatattcac
    14941 ttctaaattg atttgagctc tcctaactta tatgataaaa taagactaga aaaaggagaa
    15001 gaacctgatc gatgtagaag aaattctgtg caagatgccc cccaatcaga agattaatta
    15061 tgaccgtgtc atgcagaaaa tggtagaagt atggtagaaa aatgagcaac ggccaaccat
    15121 tctcgtgcat gtttgctgtg ccccttgtag tacctataca ctagaatatt tgaccaagta
    15181 tgcagatgtg accatctatt ttgccaattc taatatccat cccaaggtag aataccataa
    15241 gcgggtctat gtcaccaaga aatttgttag tgattttaat gagcggacag gaaatacggt
    15301 tcagtaccta gaagctccct acgaacccaa ttaataccga aaactagtta ggggactaga
    15361 ggaggagccc gaaggtggcg accgttgcaa ggtttgtttt gactaccgac tggataaaac
    15421 agcgcaagtg gctatggact tgggctttga ctactttggt tcagccttga ccatcagtcc
    15481 tcataagaat tctcaaacca tcaacagcat cggaatcgat gtgcaaaaaa tttacacgac
    15541 ccactatctt cccaacgatt tcaagaaaaa tcaaggctac aaacgttcag tagagatgtg
    15601 tgaggagtat gatatctatc gtcaatgtta ttgtggctgc gtctatgcag cccaagccca
    15661 gaatattgac ctggttcaag ttaagaagga cgctacagca ttcttgttgg gtaaggatgt
    15721 tgagaaagac tattctcata tcaaatttat agtagattga aactagaata gtacaccttt
    15781 acttctaaaa cattgttaga aatcgatttg actgtcctta tttcatttta ctatactatt
    15841 acgaaattag atatataaat gaaaacttgc ctcaaggtag gtttttttgc tagtagaaaa
    15901 gcgatagaca gaaattgttg gactcttaaa aaaatgaagt tttgctcaaa agagcttctt
    15961 aaattaaaac gagcaattat cagttcaaat ctgtttcaaa agaagaacgg ataaattaat
    16021 cgatgctttg tttttgagtt aggaagttaa gcatgccaaa ctgagtcgta ggaataaatc
    16081 tctttctagt aatgtgttgt aactctgcta taatggattt attccttttt gtgtttacac
    16141 aatttatttt atactaccaa aaaaaggtca ggattttgtt cctgaccttt gacaacttta
    16201 ccgattcttt agttctacat agcgcttgta ccaaatgttt acataggctt ctgagaaagg
    16261 accacgtcca ttgttaatcc aatcaacaag aattttgaca tgttctttta aaatatagtc
    16321 caagtcatca gaataattca ttttgcgttt gtgacgctcg tactcttcaa cgtccaagag
    16381 acgtttttcc ccatctgtaa aaattttaac atccaaatcg taatcaatat acttcagtgc
    16441 ttcttcatcc agatagtagg ggctagccat attgcaatag taagaagttc cattatcacg
    16501 aatcatggca atgatattaa accaatattt cttgtgaaag taaacaatag ccggttctcg
    16561 agtgacccaa cgacgaccat cactttcggt aacaagtgta tgatcgttga caccaataat
    16621 ggcgttttct gttgttttta gtaccatggt gtcccgccaa gttcggtgga gactcccatc
    16681 atgcttataa ctttgaattg taataaagtc gccttctttt ggaagcttca taactaacca
    16741 actttctaca atttataagt ttatcattta ctattgtacc ataaaattac ctaaaatctg
    16801 tgaatttcac ttggaaatat taaagatatt ctctaagagc gcttgctata tccgaaaaat
    16861 cgtagccctt tcgtgctaaa acttgagtta aacgctgctt cagttcgtat ccttcatact
    16921 ttcgagcata cttagtatat tgcttatcaa gttccttgaa gatgagttct tgagtcgttt
    16981 cttggtcaac ttggctatct aagtcgtcaa aggcaatttt agcatcagaa taagagaagc
    17041 ccttgttagt caagttctgg ataatcttat cttgcaaggc acgagctgga agttttccct
    17101 catatttttt caatagttta ttagctacac gttgagcaac ttcagaaaaa tcaaattctt
    17161 tcaagttctc ttctatagta gattttgaaa tccctttttg agctagtttc tgagtcagca
    17221 cataaggacc cttgtctcct gaaagttgat tggtattgat gatagcataa gcgtactgac
    17281 catcattaat ccacttatct tctttaagat tagcaataac ttgagaaacg atgtttttat
    17341 caatatcgta ttttttcaga tattctctga cttctttttc agtgcgtgct ttaaaggata
    17401 agtggtagag ggccagattc ttaccataag aaaattgagc aaagtcttga atctctttca
    17461 attcctcttc gcttatcacc ttatctctcg ataacataaa acgaacaatt gtatcttcgg
    17521 tgatatagca tttgtcgcca ttatcaagct ccatcagata gagtcttttt ttcttttcaa
    17581 gttttgtgat tttcatagct ctattataac tcaaaatgtg ataagatagg ggtatgaatc
    17641 tgaaagtgaa acaaaaaata ccattaaaaa tcaagcgcat gggaattaac ggtgagggaa
    17701 tcggctttta ccaaaaaaca ttagtctttg taccaggagc tctcaaaggc gaagatatct
    17761 attgtcagat tacttctatt agacgcaact ttgttgaagc aaaattactg aaggtcaaca
    17821 agaagtctaa atttcgaatt gtgccatctt gtactattta taatgaatgc ggaggctgcc
    17881 aaatcatgca cctgcattat gataagcagc tggagttcaa gacggactta cttcatcaag
    17941 cgctgaaaaa atttgctcct gcaggatatg aaaattatga aattcgtcca actattggaa
    18001 tgcaggaacc aaaatattac agagctaagt tacaatttca gactcgaaaa tttaaaaatc
    18061 aggtcaaggc gggcttatat gcacaaaact ctcactattt agtagagttg aaagactgcc
    18121 tggtacaaga taaggaaacc caagtgattg ctaatcgctt agcagaatta cttacttatc
    18181 accagattcc aatcacggat gagagaaaag ttctaggtgt ccgtactatt atggtccgac
    18241 gcgcgagaaa gaccggacag gttcagatta ttattgttac aaaccgccag cttaatttaa
    18301 ctcaattggt aaaagagttg gttaaagatt tcccagaagt tgtgacagta gctgttaata
    18361 caaatacagc taaaaccagt gagatatatg gtgaaaagac agagattatc tgggggcaag
    18421 agagtattca agaaggtgta ctcaattatg aattttcact atcccctcga gctttttatc
    18481 aactaaatcc tgagcaaaca gaagtcctct atagcgaagc agtaaaagcg ctggatgttg
    18541 ataaagaaga ccatttgatt gacgcttatt gtggagttgg aacgattgga tttgcctttg
    18601 caaagaaagt aaaaacactc agaggtatgg atattattcc agaagctatt gaagatgcca
    18661 agcgaaatgc taaaagaatg ggatttgaca atactcatta tgaagctgga acggcagaag
    18721 agattattcc tcgttggtac aaggaaggct accgagcaga tgctttgatt attgacccac
    18781 cacgtacagg tctggatgat aagttattag atactattct tacttatgta ccagaaaaaa
    18841 tggtttatat ttcttgtaat gtttcgacct tggctcgtga tttggtacgc ttagtagaag
    18901 tctatgatct tcattatatc cagtcggtcg atatgttccc acatacagct cgaactgaag
    18961 ctgttgtaaa attaataaaa aaagtttaaa aaaggtgttg acaaagtttg aaaagactgt
    19021 ataatagtaa gagttgaaaa taacaactca ggtccgttgg tcaaggggtt aagacaccgc
    19081 cttttcacgg cggtaacacg ggttcgaatc ccgtacggac tatggtatgt tgcggttgga
    19141 acacttgatg aaaaaaagtt taaaaaaagc ttaaaaatct tcaaaaaagt gttgacaagt
    19201 gaaagtggct gtgatatact aatatagttg tcgcttgaga gaagcaagtg acaaagacct
    19261 ttgaaaactg aacaagacga accaatgtgc agggcgctac aacataagtt gtagtactga
    19321 acaat
//
LOCUS       DAVHIZ010000033        19286 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.035, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000033 DAVHIZ010000000
VERSION     DAVHIZ010000033.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19286)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19286)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19286
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.035"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            491..805
                     /locus_tag="VVO18_001341"
     CDS             491..805
                     /locus_tag="VVO18_001341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU5586494.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            821..1207
                     /locus_tag="VVO18_001342"
     CDS             821..1207
                     /locus_tag="VVO18_001342"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU5586495.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1236..2621
                     /locus_tag="VVO18_001343"
     CDS             1236..2621
                     /locus_tag="VVO18_001343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU5586496.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2624..2776
                     /locus_tag="VVO18_001344"
     CDS             2624..2776
                     /locus_tag="VVO18_001344"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5586497.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            2799..4004
                     /locus_tag="VVO18_001345"
     CDS             2799..4004
                     /locus_tag="VVO18_001345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HEU5586498.1"
                     /translation="MEGFLLNEQTWLQHLKEKRLAYGLSQNRLAVATGITRQYLSDIE
                     TGKVKPSEDLQQSLWEALERFNPDAPLEMLFDYVRIRFPTTDVQQVVENILQLKLSYF
                     LHEDYGFYSYSEHYALGDIFVLCSHELDKGVLVELKGRGCRQFESYLLAQQRSWYEFF
                     MDVLVAGGVMKRLDLAINDKTGILNIPVLTEKCQQEECISVFRSFKSYRSGELVRKEE
                     KECMGNTLYIGSLQSEVYFCIYEKDYEQYKKNDIPIEDAEVKNRFEIRLKNERAYYAV
                     RDLLVYDNPEHTAFKIINRYIRFVDKDDSKPRSDWKLNEEWAWFIGNNRERLKLTTKP
                     EPYSFQRTLNWLSHQVAPTLKVAIKLDEINQTQVVKDILDHAKLTDRHKQILKQQSVK
                     EQDVITTKK"
     gene            4047..4268
                     /locus_tag="VVO18_001346"
     CDS             4047..4268
                     /locus_tag="VVO18_001346"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586499.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            4385..4882
                     /locus_tag="VVO18_001347"
     CDS             4385..4882
                     /locus_tag="VVO18_001347"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HEU5586500.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            4857..5363
                     /locus_tag="VVO18_001348"
     CDS             4857..5363
                     /locus_tag="VVO18_001348"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016897981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5586501.1"
                     /translation="MGFLKSSIKSVGTLLLADFLFYGVAQSATPIFYERIDYMKKIRS
                     YTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAVMILGNLPPLSMIEGAFLKYF
                     GIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTYAGKKVTLGRNQPQEAITAVR
                     SEFYGISN"
     gene            5347..7794
                     /locus_tag="VVO18_001349"
     CDS             5347..7794
                     /locus_tag="VVO18_001349"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU5586502.1"
                     /translation="MAYPIKYIENNLVWNKDGECYAYYELVPYNYSFLSPEQKIQVHD
                     SFRQLIAQNRDGKIHALQISTESSIRSAQERSKNEVTGKLKAVAYDKIDQQTDALISM
                     IGENQVNYRFFIGFKLLLNDQEFSMKSLTVEAKNALSDFVYDVNHKLMGDFVSMSNDE
                     ILRFQKMEKLLENKISRRFKIRRLDKDDFGYLIEHLYGQTGTAYEEYEYHLSKKKLDN
                     ETLIKYYDLIKPTRCLVEEKQRYLKIQQEDETVYVAYFTINSIVGELDFPSSEIFYYQ
                     QQQFTFPIDTSMNVEIVANRKALSTVRNKKKELKDLDNHAWQSDNETSSNVAEALESV
                     NELETNLDQSKESMYKLSYVVRVSANDLDELKRRCNEVKDFYDDLSVKLVRPFGDMLG
                     LHEEFLPASKRYMNDYIQYVTSDFLAGLGFGATQMLGENEGIYVGYSLDTGRNVYLKP
                     ALASQGVKGSVTNALASAFVGSLGGGKSFANNLIVYYAVLYGAQAVIVDPKAERGRWK
                     ETLPEISHEINIVTLTSDEKNKGLLDPYVIMKNPKDSESLAIDILTFLTGISSRDGER
                     FPILRKAIRAVTNSEVRGLMKVIEELRVENTPLSTSIADHIESFTDYDFAHLLFSNGY
                     VEQSISLEKQLNIIQVADLVLPDKETSFEEYTTMELLSVAMLIVISTFALDFIHTDRS
                     IFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNTDDLLDEKLKNNLGL
                     KFAFRSTDLNEIKKTLAFFGVDPEDENNQKRLRDLENGQCLISDLYGRVGVIQFHPVF
                     EELLHAFDTRPPVRKEV"
     gene            7797..9974
                     /locus_tag="VVO18_001350"
     CDS             7797..9974
                     /locus_tag="VVO18_001350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU5586503.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYAPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            9971..10972
                     /locus_tag="VVO18_001351"
     CDS             9971..10972
                     /locus_tag="VVO18_001351"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HEU5586504.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            10969..11901
                     /locus_tag="VVO18_001352"
     CDS             10969..11901
                     /locus_tag="VVO18_001352"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5586505.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYKVNPHKKVVIALWVL
                     LGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKSI
                     DNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQL
                     ITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSIT
                     TNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVTV
                     SLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            12220..14139
                     /gene="tet(M)"
                     /locus_tag="VVO18_001353"
     CDS             12220..14139
                     /gene="tet(M)"
                     /locus_tag="VVO18_001353"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HEU5586506.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYH
                     GSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLH
                     LRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLG
                     KVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVS
                     PLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
     gene            14503..14748
                     /locus_tag="VVO18_001354"
     CDS             14503..14748
                     /locus_tag="VVO18_001354"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586507.1"
                     /translation="MRQIGVSYSGFVDESYTLLSLFDDVEQIEKDNRLQTAIDVVREQ
                     FGFLAIQKGTVLTEGSRNIERSKLIGGHSAGGLEGLK"
     gene            14745..15080
                     /locus_tag="VVO18_001355"
     CDS             14745..15080
                     /locus_tag="VVO18_001355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imsC-like protein"
                     /protein_id="HEU5586508.1"
                     /translation="MKQEKNTVQFSEIRSKGCNDIEMLERFLHGIVETATSKLRQRKL
                     KTTEISIRLVHAKSENRLPLEFTFSIKPTSSSVIIYTEVINRFKECYTGGGIQGFTIQ
                     FDKNTLASA"
     gene            15093..15461
                     /locus_tag="VVO18_001356"
     CDS             15093..15461
                     /locus_tag="VVO18_001356"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586509.1"
                     /translation="MIDRSYLPFQSAREYQDTKMQKWMGFFLSEHASALSDDTNKVTY
                     MSDLSLEKKLLLLSQVYAGQLRTRIQVIEKNKRVSYTGTIPSLTKDFILIKTTTGHIN
                     LKLKDIISIELVEEVLYESA"
     gene            15448..15747
                     /locus_tag="VVO18_001357"
     CDS             15448..15747
                     /locus_tag="VVO18_001357"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586510.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVSTVDENPLIYHYTYKKTTIYLAEK"
     gene            complement(15865..17328)
                     /gene="msr(D)"
                     /locus_tag="VVO18_001358"
     CDS             complement(15865..17328)
                     /gene="msr(D)"
                     /locus_tag="VVO18_001358"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEU5586511.1"
                     /translation="MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKS
                     TLLRVLLGELTPPGCKMNRLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEDGGRLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGIG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKINLKH"
     gene            complement(17448..18665)
                     /gene="mef(A)"
                     /locus_tag="VVO18_001359"
     CDS             complement(17448..18665)
                     /gene="mef(A)"
                     /locus_tag="VVO18_001359"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEU5586512.1"
                     /translation="MEKYNNWKRKFYAIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLVGFLPYAILGPAIGVLVDRHDRKKIMIGADLIIAAAGAVLAIVAFCMELPV
                     WMIMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWDLNAIIAIDVLGAVIASITVAIVRIPKLGNQVQSLEPNFIREMKEGVVVLRQN
                     KGLFALLLLGTLYTFVYMPINALFPLISMEHFNGTPVHISITEISFAFGMLAGGLLLG
                     RLGGFEKHVLLITSSFFIMGTSLAVSGILPPNGFVIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLIGSIMSLAMPIGLILSGFFADKIGVNHWFLLSGILIIGIAIV
                     CQMITEVRKLDLK"
     gene            complement(19051..19221)
                     /locus_tag="VVO18_001360"
     CDS             complement(19051..19221)
                     /locus_tag="VVO18_001360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombinase"
                     /protein_id="HEU5586513.1"
                     /translation="MKYFEVELENPDEFLKLQTEDFVKANRLLLRKIIQSVTVYEENF
                     VISFKSGIELEV"
BASE COUNT         6201 a         3617 c         3823 g         5645 t
ORIGIN      
        1 aacagtttat tcagaagaat aaacaattgg aagttcgagt acaatcacaa aaggagtcca
       61 atggtcttga tgttgggaag gctgattagt tgattaaatg atgaaaatac taattaacta
      121 tatggtattt ctgttttatc taatttttaa ttagaaaaat agcataaaaa tctagttatc
      181 cgcataaaaa ctggacttat cacactttat caaggtcaaa accactcaat ttactactaa
      241 tttactactt atgaatgagc tttgatacga cgatttatcc ttgaaaagtg aagatataaa
      301 gatacttcca ataaaatttg aatatttaat aggtagacac ttcaaaaaat gaggtgtcta
      361 tttttttacc cgattttgaa aggaagtgaa cttatgaaaa caaaaaatca agaatcaaaa
      421 ggtcgttccc cactctttaa gaccatcaaa cattcattca gccaataaaa aagaaaggat
      481 aggtaaaaat atggaactta aatttgtgat tcccaacatg gaaaaaacat tcggcaattt
      541 agaatttgct ggcgaggata aagtcgttca gcgaagaatc aacggacggc taactgtctt
      601 atcaagaagc tataatctct attctgatgt tcaaagagca gatgatattg tggtggtgct
      661 tcctgctgaa gctggcgaaa aacatttcgg ctttgaggaa cgtgtgaagt tagtcaatcc
      721 acgtattacc gcagagggct acaaaatcgg cactcgtggt tttacaaatt accttttaca
      781 tgctgacgac atgataaaag aataaagaaa gagaggaaaa atgatgagat tagcaaatgg
      841 cattgtatta gataaagaca cgacttttgg agaattgaaa ttctctgctc tacgtcgtga
      901 agtgagaatc caaaatgaag acgggtcggt ttcagatgaa atcaaggaac gtacctatga
      961 cttaaaatcc aaaggacaag gacgcatgat tcaagtaagt attcctgcca gcgtgccttt
     1021 gaaagagttt gattataacg cacgggtgga acttatcaat cccattgcgg acaccgttgc
     1081 tactgccacc tatcaaggag cagatgttga ctggtatatc aaggcagacg atattgtgct
     1141 gacaaaggat tctagttcat tcaaagctca accacaagca aagaaagaac cgacacaaga
     1201 caaatagtcg ctaggtagaa aggagacttt ttcgcatgaa acagcgtggt aaaaggattc
     1261 gcccatctgg taaagattta gtctttcatt ttacgatagc gtcactcctg cctgttttcc
     1321 tgctggttgt cggactgttt catgtgaaga caatccagca gatcaactgg caggatttta
     1381 acctatcaca agcagataag attgacattc cctatttaat tatcagtttc agtgtcgcaa
     1441 ttcttatctg cttgctggta gcgtttgtat tcaaacgggt tcgctatgat acggttaaac
     1501 aactttacca ccgtcaaaaa ctggcaaaga tgatacttga aaacaagtgg tatgaatctg
     1561 aacaggtcaa aacagagggt ttctttaaag atagtgctgg tcgtacaaag gaaaagataa
     1621 cctacttccc taaaatgtat tatcgactta aaaatggctt gatacagata cgggtggaaa
     1681 tcacgctggg aaaatatcaa gaccaactct tacacttgga aaagaaatta gagagtggct
     1741 tgtactgtga gctgacggat aaagagttaa aggattccta tgtggaatat actttgctct
     1801 atgacaccat agccagtcgt atttctattg atgaagtaga agctaaagat ggtaaacttc
     1861 gcttaatgaa aaacgtatgg tgggaatatg ataagctccc tcatatgttg attgctggtg
     1921 gtacaggtgg cggtaaaact tactttatac tgacactgat tgaagccttg cttcatacag
     1981 attcaaaact gtatattctt gacccgaaaa atgctgacct tgcggactta ggttctgtga
     2041 tggcaaatgt ctactataga aaagaagact tgctttcttg cattgaaaca ttctatgaag
     2101 aaatgatgaa acgtagtgag gaaatgaagc agatgaagaa ctataagact ggcaaaaatt
     2161 atgcttactt aggtctcccg gcacacttct taatctttga tgaatacgtc gctttcatgg
     2221 aaatgctggg aacaaaagaa aacaccgcag ttatgaataa gctgaaacag attgtcatgt
     2281 taggtcgtca agctggcttc tttctaatac tggcttgtca acgtccagac gcaaaatatt
     2341 taggcgacgg aatccgtgat cagtttaatt tcagagtggc tttaggtcgt atgtctgaaa
     2401 tgggctatgg catgatgttt ggcagtgacg tacaaaagga tttcttctta aagcgaatca
     2461 aaggtcgtgg ctatgttgat gtaggaacaa gtgtcatatc agagttttat actccccttg
     2521 taccaaaagg atatgatttc ttggaggaaa ttaaaaagtt atccaacagc agacagtcca
     2581 cgcaggcgac gtgcgaagcg gaagtcgcag gtgtggactg atcttgctgg ctggtgtggc
     2641 aatagccacg ccagcactta accccccgta tctaacaggg gggtacaaat cgacaggaaa
     2701 cagtcaaaaa aacattagaa aatcctttgg ttacaaggga tttacaaaat ttcagcgtat
     2761 gtcaaatggg ctttaaaagt tgacatacgc ctttttgatt ggagggattt ttactgaatg
     2821 aacaaacttg gttacagcat ttaaaagaaa aacgcttggc ttatggacta tctcaaaacc
     2881 gtttagctgt tgcgactggt attacaaggc agtatctaag cgatattgaa acaggaaaag
     2941 tcaagccatc agaggattta cagcagtccc tttgggaagc tctggaacgc ttcaatcccg
     3001 acgctcccct tgaaatgctg tttgattatg taaggattcg ctttccgaca acagacgtac
     3061 agcaggtggt cgaaaacatc ttacaactga aactgtccta ttttcttcat gaggactatg
     3121 gtttctattc ttattcagag cattatgctt taggcgacat attcgtcctt tgctcccatg
     3181 aactggacaa aggagttctg gtggaattga aaggtcgtgg gtgcagacaa tttgaaagct
     3241 atcttctggc acaacaaaga agctggtatg agttctttat ggacgttttg gtggctggcg
     3301 gtgtgatgaa acgccttgac cttgccatta acgataagac agggattttg aatatccctg
     3361 tactcactga aaagtgccaa caggaagaat gtatctccgt cttccgcagt tttaaaagct
     3421 atcgcagtgg cgaactggta cgcaaagagg aaaaggaatg tatgggaaac accctctata
     3481 tcggttcatt acaaagtgaa gtttatttct gtatctatga aaaggactac gagcagtaca
     3541 agaaaaatga tattcccatt gaagacgcag aagtaaaaaa ccgttttgag attcgattga
     3601 aaaatgagcg tgcctattat gcagtccgtg atttactcgt ctatgacaat ccagagcata
     3661 ccgcctttaa aattatcaat cggtatatcc gttttgtaga taaagacgat tccaaacctc
     3721 gttctgattg gaaactgaat gaagaatggg cttggtttat tgggaacaat cgtgaacgat
     3781 taaaactaac cacaaaacca gagccttact ccttccaaag gacgctgaac tggctatctc
     3841 atcaagttgc cccgacctta aaggttgcga ttaaacttga tgaaatcaac cagacgcagg
     3901 ttgtaaaaga cattctcgac catgcgaaac tgacagaccg acacaagcag attttgaagc
     3961 aacagtcagt aaaagaacag gacgtgataa caacaaaaaa ataactcaaa tacaaattca
     4021 ttgaatatag agaggagaac atttttatga attttggaca aaacctttat aactggtttc
     4081 tatcaaacgc tcaatcactg gtgcttttag caatcgttgt gattggcttg tatcttggct
     4141 tcaagcgtga gtttagcaaa ctgattggct ttttaattat tgcgattatt gcggttggct
     4201 tagtcttcaa cgctgctgga gtaaaagaca ttttactaga gctattcaat cgcattattg
     4261 gtgcttaaat aaaaccgttc ttttgtggaa tataagtggt tttcttatgt tccgcaaagg
     4321 aatggtacac caaacgaagt gcggtaggga tttttgaatc tctacaaaga aaggacgtga
     4381 atatatggac gatatgcaag tctatattgc gaatttaggc aaatacaatg agggcgaatt
     4441 ggtcggtgcg tggtttacct ttcccattga ctttgaggaa gtcaaagaga aaatcggctt
     4501 gaatgatgaa tatgaggaat acgccattca tgactacgag ttacccttta cggttgacga
     4561 atacacttcc attggcgaac tcaatcgact atgggaaatg gtatcggaat tacccgaaga
     4621 attacaatcg gagctatctg ctctgctcac tcatttttca agcattgaag aactaagcga
     4681 acatcaagag gatattatca ttcattccga ttgtgatgat atgtatgacg tggcacgcta
     4741 ctacattgaa gaaacgggtg ctttaggcga agtaccagct agtcttcaaa actatattga
     4801 ttatcaagcc tatggtcggg atttagacct ttcaggaacg tttatctcaa ccaatcatgg
     4861 gatttttgaa atcgtctatt aaatctgtcg gtacattact actggcagat tttctatttt
     4921 acggggtggc tcaatcagct acccctattt tttatgaaag gattgattac atgaagaaaa
     4981 tacgaagcta taccagtatc tggtctgtgg aaaaggtact gtattctatc aatgatttta
     5041 gacttccgtt tcccataacc tttacgcaaa tgacatggtt tgtcgtgtca ctctttgcag
     5101 tgatgatact tggcaacttg ccccctcttt ccatgataga gggagcattt ctcaaatact
     5161 ttgggattcc tgtggctttc acatggttta tgtctacaaa aacttttgat ggtaaaaagc
     5221 cttatggatt tttgaagtct gtcattgctt atgcactgcg accaaagctg acctatgcag
     5281 gaaaaaaagt aacgcttggc agaaaccagc cacaagaagc cattacagca gttaggagtg
     5341 aattttatgg catatccaat taaatacatt gaaaacaatc tcgtctggaa taaagacggg
     5401 gaatgttatg cttactatga gcttgttcct tacaattact catttctaag tccagaacag
     5461 aaaatacaag tgcatgattc tttcagacag cttatcgcac aaaatcgtga tggcaaaatt
     5521 catgctttac aaatcagtac agaatccagc atacgttctg cacaagagcg ttccaaaaat
     5581 gaagtcactg gcaagctcaa agcggttgcc tatgacaaaa tcgaccaaca gacagacgct
     5641 ttaatatcca tgattggcga aaatcaagtg aactaccgtt tctttatcgg ctttaagttg
     5701 cttctcaacg atcaggagtt ttctatgaaa agtcttaccg ttgaagcaaa aaatgctttg
     5761 tctgattttg tctatgatgt gaaccataag ctgatgggcg attttgttag tatgagtaat
     5821 gatgaaatcc tgcgttttca gaagatggaa aagctcttag aaaataaaat ctctcgtcgt
     5881 ttcaaaatcc gcaggttaga taaggacgac ttcggctatc tgattgaaca cctttacgga
     5941 cagacaggca ctgcctatga agagtatgag taccatctat caaagaaaaa gctggataat
     6001 gaaacgctga ttaaatacta tgacttgatt aagcctactc gctgtttggt ggaagaaaaa
     6061 cagcgatatt tgaaaatcca gcaggaagat gaaaccgtct atgtagctta ctttaccatt
     6121 aacagcattg tcggagaact ggacttcccg tcctctgaaa tcttctacta ccagcaacag
     6181 caatttacat tcccgattga tacgtcaatg aatgtggaaa ttgtagcgaa tcgtaaagcc
     6241 ctatctactg tccgcaataa aaagaaagaa ctgaaagact tggataacca cgcttggcaa
     6301 agtgataatg aaaccagctc caatgtggcg gaagctctgg aaagtgtgaa tgagctggaa
     6361 accaatttag accaaagcaa ggaatctatg tacaagctgt cttatgtggt aagggtatca
     6421 gcaaatgatc ttgacgaact caaacgtcgt tgtaatgaag tgaaagattt ttatgacgat
     6481 ttaagcgtaa aactggtacg accatttggg gatatgctcg gcttacatga agaattttta
     6541 cctgccagca agcgttatat gaatgattat attcaatacg tgacctctga tttcctcgct
     6601 ggtttaggtt ttggtgctac tcaaatgctg ggggaaaatg aggggattta tgttggctac
     6661 agcttagata ctggacgcaa tgtctatctg aaacctgctc ttgccagtca aggggttaag
     6721 ggttcagtaa ccaatgcgtt agcgtcggct tttgttggtt cgctgggtgg tggtaaatcc
     6781 tttgcgaata accttatcgt ctattatgcg gtgctttatg gggcacaagc agtgattgta
     6841 gacccaaaag cagaacgtgg cagatggaaa gaaaccttgc cagagatttc ccatgaaatc
     6901 aatatcgtca ctctgacttc tgatgagaaa aacaaaggct tacttgaccc ttatgtgatt
     6961 atgaaaaatc ccaaagattc tgaatcactg gctattgata ttctgacatt ccttacgggg
     7021 atttcctctc gtgatgggga acgcttccca atccttagaa aagccattcg tgcagtaacc
     7081 aatagtgaag tacgagggtt gatgaaagtg attgaggaat tacgggttga gaatacgcca
     7141 ctaagtacca gtatagccga ccatatcgaa agttttacag actatgactt tgcacattta
     7201 ttattcagta atggttatgt ggagcagtct atcagcttag aaaaacaact gaacattata
     7261 caggttgcgg acttggtact tcccgacaag gaaacttcct ttgaggaata taccactatg
     7321 gagcttttat ccgttgctat gctgattgtc attagtacct ttgctttaga ctttatccat
     7381 acagaccgaa gcattttcaa gattgtagat ttagacgaag catggagctt tttacaggta
     7441 gcacaaggaa aaacactatc tatgaagctg gttcgggctg gtcgtgctat gaacgctgga
     7501 gtatatttcg tgacccaaaa tacagacgac ctcttagatg aaaaactgaa aaataacctc
     7561 ggcttaaaat ttgcatttcg ttccactgac cttaacgaga ttaaaaagac cttagccttt
     7621 tttggtgtag acccagagga cgaaaacaat cagaagcgat tgcgtgattt ggaaaacggg
     7681 caatgcctta tcagtgattt atatggtcgt gtcggtgtga tacagttcca ccctgtattt
     7741 gaagaactgc tccatgcctt tgataccaga ccacctgtgc gaaaagaggt gtaaatgtga
     7801 aaccatcaat agtaaacaga ataaaatcaa actggacgct gaaacgtcta ggtaaagtgg
     7861 caatgacagt ggctttcaca cttgtgattg ccatttttct tttagccatg ctgggaacgg
     7921 tggttcaagc tgcgggcttg gtagatgata cggtcaatgt ggcaaatgaa tacagccgat
     7981 acccacttga aaactatcaa ctggattttt atgtggataa tagctggggc tggcttccgt
     8041 ggaactggtc ggacgggatt ggaaaacagg tcatgtatgg actatatgcc attaccaatt
     8101 ttatttggac aatcagtttg tatgtttcca atgcgacagg ttacttagta caggaagcct
     8161 attccttaga cttcatttcc gctacagcag attccattgg taagaatatg cagaccttag
     8221 ctggtgtgag tgcaaacgga ttttcaacag agggtttcta tgttggattc ctcttactct
     8281 tgattttggt tcttggggtt tatgttgcct atacgggact gataaagaga gaaaccacaa
     8341 aggcaattca tgccattatg aattttgtgc tggtgtttat cctatcggct tcctttattg
     8401 cctacgctcc cgactacatt aaaaaaatca atgacttttc atcagacatc agtaatgcca
     8461 gtttatcact tggcacgaag attgtcatgc cccattccga tagtcaaggc aaggacagcg
     8521 tggacttaat cagagatagc ctgttttcca tacaggttca gcaaccgtgg ctactgcttc
     8581 aatacaacag ttcagacatt gaaagtatcg gtattgaccg tgtggaaagc ctgctctcca
     8641 ccagcccaga ttccaacaat ggcgaagaca gagaaaaaat tgttgcggaa gaaattgaag
     8701 acagaagcaa taccaatcta accattacaa agaccattaa ccgtttaggt acagtcttct
     8761 tcctatttgt cttcaatatt gggatttcca tatttgtatt cctattaaca ggaatcatga
     8821 ttttctcgca ggtacttttt atcatctatg ctatgtttct gcctgtgagc tttattttaa
     8881 gcatgattcc atcatttgat ggtatgtcaa aacgagccat aacaaagctc tttaatacca
     8941 ttttgacacg agctggaatc acattgatta ttacgacagc atttagtatt tcaaccatgc
     9001 tctatacctt atcggctggt tatccgttct ttttgattgc ttttctacag attgtgacct
     9061 ttgcaggaat ctacttcaag ctgggcgatt taatgagtat gttttctcta cagagtaacg
     9121 attctcaaag tgtgggaagt cgtgtgatga gaaaacctcg tatgcttatg cacgctcaca
     9181 tgcaccgtct acagcggaaa cttggacgtt ccatgactac tctaggggct gggtctgcca
     9241 ttgttacagg taaaaaagga cagtcgggtt cggggagttc tgcaaggaca caagcagatc
     9301 actcccgacc agacggaaag gaaaaatcaa cacttggaaa acgtatcggt caaaccatcg
     9361 gtacagtagc tgataccaaa gacagaatgg tagacactgc tagtggtttg aaagaacagg
     9421 ttaaagattt gccgaccaat gcaagatatg cagtatatca aggaaaatcc aaagtaaaag
     9481 agaatgtccg tgatttaacc agtagtattt ctcaaaccaa agcggacaga gccagtggac
     9541 gcaaggaaca gcaggaacaa aggcgaaaaa ccattgcgaa gcgtcgctct gaaatggaac
     9601 aggtcaaaca gaaaaaacag cctgcttctt ctgttcatga aagaccgact acaagacaag
     9661 aacaatatca tgatgaacag acctcaaaac agtctaatat tcagacttca tataaggaat
     9721 ctcaacaagc caaacaagag cgtccagcag ttaagtccga tttttcaagt ccaaaagtgg
     9781 aacgccaagg caataccgtt caagaaaaaa ccgttcaaaa gccagcaact tcaaccacta
     9841 cagcagatag aacttcacaa cgtccaatca caaaagaacg tccgtctact gttcaaagag
     9901 taccactaca aaatacaaga agtagaccac caatcaaaac cgccaccatt aagaaagtcg
     9961 gtaagaaacc atgaagttga aaactttagt gattggtggt tctggattat tcttgatggt
    10021 cttctcactg cttctgtttg ttgccatttt attttcagat gaacaggaca gcggaatttc
    10081 caatattcat tatggaggtg tgaatgtttc cgcagaagtg ctggctcata agcctatggt
    10141 agaaaaatat gccaaagaat atggcgttga agaatatgtc aacatacttc ttgcgattat
    10201 acaggtggaa tcgggcggta ctgcggaaga tgttatgcag tcctcggaat ccctcggtct
    10261 tccacctaat tcattgagta cagaagaatc cattaagcaa ggtgtgaagt atttcagtga
    10321 attattagcc agtagcgaaa ggctcagtgt agatttagaa tcggttatcc agtcctacaa
    10381 ttatggtggt ggtttcttag ggtatgtggc taatcgtgga aataaatata cctttgaact
    10441 ggctcaaagt ttctcaaaag agtattcagg tggcgaaaaa gtgtcttacc ccaatcccat
    10501 agccatacct atcaatgggg gctggcgata caactatggc aatatgtttt atgtgcaact
    10561 ggtaacgcag tatcttgtca caacagagtt tgatgatgat acggtacaag ccatcatgga
    10621 cgaagcactg aaatatgagg gctggcgata cgtttacggt ggagcttccc cgactacttc
    10681 ttttgattgt agcggactga cacaatggac gtatggaaaa gctggaatta acttaccacg
    10741 aaccgcacaa cagcaatatg atgtgaccca gcatatccca ctatcggaag cacaagctgg
    10801 cgatttggtt ttctttcatt ctacctataa cgctggctct tatattactc atgttgggat
    10861 ataccttggc aataaccgta tgtttcatgc aggcgaccca atcggttatg ccgacttaac
    10921 aagcccctac tggcaacagc atttagtggg agcaggacga atcaaacaat gagaaaggaa
    10981 gatttaatga tgaaatttag aaaaaatcag aataaagaaa aacagatacc aaaggaaaag
    11041 aaacctcgtg tctataaggt caatcctcat aaaaaggttg tgattgcctt gtgggtactt
    11101 ttagggctta gtttcagctt tgcgatattc aagcacttta cagctataga tactcatact
    11161 attcacgaaa caactatcat agaaaaggaa tacgttgata ctcatcatgt agaaaatttt
    11221 gtagagaact ttgcgaaagt ctactattca tgggagcaat ccgataagtc cattgataat
    11281 cgaatggaaa gtctaaaagg ctatctgaca gatgaacttc aagctctcaa tgttgataca
    11341 gtacgcaaag atattcctgt atcgtcttct gtaagaggat ttcagatatg gacggtagag
    11401 ccaactggcg acaatgagtt taatgtaacc tacagtgtag accagctcat tacagaggga
    11461 gaaaatacaa agaccgtcca ctctgcttat atagtgagtg tctatgtaga tggttctgga
    11521 aatatggtac tggttaagaa tccgaccatt accaacatac ctaagaaatc aagttataaa
    11581 ccaaaagcca ttgaaagtga ggggacggtt gattccatta caaccaatga aatcaatgag
    11641 tttttaacga cgttcttcaa gctctatcct acagcgacag ccagtgaact ttcctactat
    11701 gtgaatgacg ggatattaaa accaatcgga aaagagtaca tctttcaaga actggtaaat
    11761 cctattcaca atcgtaagga taatcaagtc acggtatcgc tgacagtgga gtatatcgac
    11821 cagcagacca aagcaacgca ggtatctcaa tttgatttgg tacttgaaaa gaacgggagt
    11881 aattggaaga ttatagaata acaaatattg gtacattatt acagctattt tgtaatcacg
    11941 tactctcttt gataaaaaat tggagattcc tttacaaata tgctcttacg tgctattatt
    12001 taagtatcta tttaaaagga gttaataaat atgcggcaag gtattcttaa ataaactgtc
    12061 aatttgatag tgcgaacaaa taattggatg tcctttttta ggagggctta gttttttgta
    12121 cccagtttaa gaataccttt atcatgtgat tctaaagtat ccggagaata tctgtatgct
    12181 ttttatgccc ttttgggctt ttgaatggag gaaaatcaca tgaaaattat taatattgga
    12241 gttttagctc atgttgatgc gggaaaaact accttaacag aaagcttatt atataacagt
    12301 ggagcgatta cagaattagg aagcgtggac aaaggtacaa cgaggacgga taatacgctt
    12361 ttagaacgtc agagaggaat tacaattcag acaggaataa cctcttttca gtgggaaaat
    12421 acgaaggtga acatcataga cacgccagga catatggatt tcttagcaga agtatatcgt
    12481 tcattatcag ttttagatgg ggcaattcta ctgatttctg caaaagatgg cgtacaagca
    12541 caaactcgta tattatttca tgcacttagg aaaatgggga ttcccacaat cttttttatc
    12601 aataagattg accaaaatgg aattgattta tcaacggttt atcaggatat taaagagaaa
    12661 ctttctgccg aaattgtaat caaacagaag gtagaactgt atcctaatat gtgtgtgacg
    12721 aactttaccg aatctgaaca atgggatacg gtaatagagg gaaacgatga ccttttagag
    12781 aaatatatgt ccggtaaatc attagaagca ttggaactcg aacaagagga aagcataaga
    12841 tttcataatt gttccctgtt ccctgtttat cacggaagtg caaaaaacaa tatagggatt
    12901 gataacctta tagaagtgat tacgaataaa ttttattcat caacacatcg aggtcagtct
    12961 gaactttgcg gaaaagtttt caaaattgag tattcggaaa aaagacagcg tcttgcatat
    13021 atacgtcttt atagtggcgt actgcatttg cgagattcgg ttagaatatc ggaaaaggaa
    13081 aaaataaaaa ttacagaaat gtatacttca ataaatggtg aattatgtaa aatcgataag
    13141 gcttattccg gggaaattgt tattttgcag aatgagtttt tgaagttaaa tagtgttctt
    13201 ggagatacaa agctattgcc acagagagag agaattgaaa atcccctccc tctgctgcaa
    13261 acgactgttg aaccgagcaa acctcaacaa agggaaatgt tacttgatgc acttttagaa
    13321 atctccgaca gtgacccgct tctgcgatat tatgtggatt ctgcgacaca tgaaatcata
    13381 ctttctttct tagggaaagt acaaatggaa gtgacttgtg ctctgctgca agaaaagtat
    13441 catgtggaga tagaaataaa agagcctaca gtcatttata tggaaagacc gttaaaaaaa
    13501 gcagagtata ccattcacat cgaagttcca ccgaatcctt tctgggcttc cattggttta
    13561 tctgtatcac cgcttccgtt gggaagtgga atgcagtatg agagctcggt ttctcttgga
    13621 tacttaaatc aatcatttca aaatgcagtt atggaaggga tacgctatgg ctgtgaacaa
    13681 ggattgtatg gttggaatgt gacggactgt aaaatctgtt ttaagtatgg cttatactat
    13741 agccctgtta gtaccccagc agattttcgg atgcttgctc ctattgtatt ggaacaagtc
    13801 ttaaaaaaag ctggaacaga attgttagag ccatatctta gttttaaaat ttatgcgcca
    13861 caggaatatc tttcacgagc atacaccgat gctcctaaat attgtgcgaa catcgtagac
    13921 actcaattga aaaataatga ggtcattctt agtggagaaa tccctgctcg gtgtattcaa
    13981 gaatatcgta gtgatttaac tttctttaca aatggacgta gtgtttgttt aacagagtta
    14041 aaagggtacc atgttactac cggtgaacct gtttgccagc cccgtcgtcc aaatagtcgg
    14101 atagataaag tacgatatat gttcaataaa ataacttagt gtattttatg ttgttatata
    14161 aatatggttt cttgttaaat aagatgaaat attttttaat aaagatttga attaaagtgt
    14221 aaaggaggag atagttatta taaactacaa gtggatattg tgtgctgaga gctttcttct
    14281 atactaatag acgaaagggt gtgaaaatga tttttaaatg atactgtgga acggaacagt
    14341 agccctagta ttgactactg tcgtttctat tcatattggc tattctagga ctgagatgaa
    14401 aaaatctata aatgctcaga ataaaattga acccgcaaat ctccccaaaa caatggtgag
    14461 tcatgtactt gtattattcc gaaaaaatac acctctggtg cagtgagaca aattggtgta
    14521 tcttatagtg gcttcgtaga tgaaagctat actctactat cactctttga tgatgtagaa
    14581 caaattgaaa aagataatag acttcagaca gctattgatg ttgtcagaga acagtttggt
    14641 tttttagcca tacaaaaagg aaccgtccta actgaaggtt ccagaaatat tgaacgcagt
    14701 aaacttatcg gtggtcattc cgcgggtgga ttggagggat taaaatgaaa caagaaaaaa
    14761 atacagtaca attttcagaa atccgtagca aaggatgtaa tgatattgaa atgcttgaaa
    14821 gatttttaca tggaatcgtt gaaacagcaa cttcaaaact tcgtcagaga aaactcaaaa
    14881 caactgaaat atcgatacga ctagtacatg ctaaatctga aaaccgatta ccattggaat
    14941 ttacatttag cattaagcca acaagctcat ctgtgataat ctatactgag gtaatcaatc
    15001 gctttaaaga atgttacaca ggtgggggaa ttcaaggttt tacgattcaa tttgataaaa
    15061 atacccttgc ctctgcatag aaaggatttg atatgattga ccgttcatat ttaccatttc
    15121 aatcagcaag agagtaccag gatacaaaga tgcaaaaatg gatgggcttt ttcctatctg
    15181 aacatgcatc agcactctct gatgatacaa acaaagtaac gtacatgtct gacttatcac
    15241 tagagaagaa attattactc ctcagtcaag tatacgccgg gcagctacgc acacgcattc
    15301 aagtgattga aaaaaacaag cgtgtttcct acactggaac aataccaagt ctgaccaaag
    15361 atttcatttt gataaaaact acaacaggtc acatcaattt gaaattaaaa gacattatta
    15421 gtattgaact tgtcgaggag gtgctctatg aatcagcttg agtttcagcg taatcaccta
    15481 caaatggact attatagcga gagctaccaa gattttgaac gtgacttcta ccgctactct
    15541 aacatgaata ttccattgac cttcctaact gatgatatcc taaaaacaat ggcgacttca
    15601 cgtaagaatt actttgtcct caataaggaa aagtccagag ataaccgcga tcacttcttc
    15661 atatttgaag taagtaccgt agatgagaat ccgctaatct atcattatac atataagaaa
    15721 actacaatat atttagcaga aaaataggag cagttcaatt gactgttcct atttttaata
    15781 ttcataaaat ctaaagtctt tatactcttt aacaatggag tcgccaacca gaacagacta
    15841 tactgaccag cgactacctt aaatttaatg tttcagattt attttcttat ctctaatttc
    15901 ataaactaca tctgctacat tttcgagtaa tcgtttatcg tgggtgataa acacgatagt
    15961 tccggtgtac tccttcatta gtatttccaa agcctctaaa cttggtatgt caaggaagtt
    16021 actgggttca tccattatta ggatgttata tctacccatg agcattttag caagcaacaa
    16081 ttttataatt tctccaccgc ttaaaacaga taaacttttt ccaatatcgt tctgtttgaa
    16141 ccccatagat gctagcactg aacgaatttc tgatatattg tagtcacaat ccttctgcat
    16201 aaactccata acattctgat tactgttgta cttgtaacca ttctgtgcaa agtaacctat
    16261 ttttgcctta ggcgaaatag aaattccttc ttcatggttt aagatcattt ggattaaagt
    16321 tgtttttccg attccattac caccagttaa cgccactttt gctcctaacg gaatttgaaa
    16381 agatgcattt tcaaacagag ccttatcccc aaatacttta ttaatttctg caccgactat
    16441 agggtatgga ttatggagct ccaatgcttt actttgcctg aaacgaattc tgcgaatgcc
    16501 ttccggagct tctacttttc ctaaggccgc aatcctgtgc tctagggttt tagcagcatt
    16561 atacatcttt ttttccttac ttcctattga tttttgatga gctaaacgcc ctccgtcttc
    16621 agtacttttt ttctttgaag aaccttttgc cttctgttct attttacgag cctgttttcg
    16681 cttttcctcc gcagcccttt ccaatcgggc acgttccgca ataaattgtt cgtattctgc
    16741 agcttggctc ttacgttctt cctctttctg acgaagataa tcagaatagt ttccccaata
    16801 ctcagtgatt ttgccatctt tcagttccca tattttatct actatttcat caagaaaata
    16861 gcggtcatgg ctaataacta acagtgcacc tgtaaaatat tttagctgtc ctattagaaa
    16921 atcaattcct tcacggtcta aatggctcgt aggttcatcc gctaaaatac catgaacctg
    16981 tgccgataag gcctgtgcta ttttaagcct tgtttcttca ccaccgctca tagtctgtat
    17041 atttaattgc tcaacaccta gcttgcctac aagtgcaaaa tctttttcct cctgcagagt
    17101 tacttcgtcc aactggggaa tataggcaag ttcacccaga cgattcattt tacatcctgg
    17161 gggagttaat tctcctaaaa gtaccctgag taaagtgctt tttccagcac catttgctcc
    17221 tactaaacca atacggtcat aatcatatac ttctaattca tttatatcta aaacatcgcg
    17281 tcctttgaat tccacacgaa tgtcttttgc ttttaatatt aattccataa catttcctcc
    17341 tgtctataat cgcatgcttt catttgcttg tatgcaggga aaaccctgcg attttagcag
    17401 gaagagttac atgaaaataa gatacataaa tattcctcca atattgttta ttttaaatct
    17461 aattttctaa cctcagttat catttggcaa actatagcaa tgccaataat taaaatacct
    17521 gatagtaaaa accaatgatt tacaccgatt ttatcagcaa agaatccaga aagaattaac
    17581 ccaattggca tagcaagtga catgatactt ccgatcaaag aaaatacacg tcctaaatat
    17641 tcaggcttaa ttttctcctg aaaaagagct gtttgcacac cgctataaaa tggcaccgaa
    17701 agccccatta ttgcacagca aactacgaat attacaaatc catttggagg aagtattccc
    17761 gaaacggcta aactggtccc cattataaaa aatgaacttg ttattagtaa tacatgcttt
    17821 tcgaagcccc ctaatcttcc taataataag cctcctgcta gcatcccaaa tgcaaaggaa
    17881 atttccgtaa tagaaatatg cacaggcgtt ccattaaagt gttccatgct tattaaagga
    17941 aatagtgcat tgattggcat ataaacaaaa gtatatagtg ttcctaagag taataaggca
    18001 aacaatcctt tgttttgtct cagaaccaca actccttctt tcatctccct tatgaaattt
    18061 ggttctaaac tttgcacttg attacccagc ttaggtatac gtacaattgc taccgtaata
    18121 gatgcaatca cagcacccaa tacgtcgatg gcaataatag catttaaatc ccaaacggag
    18181 tataagagtg ctgcaactgc cggactaaca atatagctta tagactgcaa agactgacta
    18241 tagcctgcgc atttcgttag ctgttcttct ggtactaaaa gtggtgtaac cgcattgagt
    18301 gctggggtat gaaaagctgt tccaatgcta cggataaaca atactatcat aatcatccag
    18361 acaggtagct ccatacagaa tgcaacaata gcaagcactg caccagctgc tgcgataatt
    18421 aaatcggcac caatcattat cttcttccta tcatgacgat ccactagcac accaatggca
    18481 ggtcccaaaa tcgcataggg taaaaaacct actaatgaag ccatagacaa gaccatcgca
    18541 gatcctgttt tttctgtaag gtaaaaaata atcgccattt gcaggatggc actagtgatt
    18601 aatgatactg cttgccctgc ccatattgca taaaattttc gtttccaatt gttgtatttt
    18661 tccatttata ttatctcctg catattattt tgcttgaatt tctattttga atagcattct
    18721 aggcaataaa aaatgcaggc caaaccccac aatgtggctt ttggtctgca tacatacaat
    18781 ttggaaacat tcatattaaa gacatagtta aataaaggta tagttaaata accaatatcc
    18841 tcaccgtaac taatgaatgc tcaatatcgt ataaataagc acaacaaaaa agcctatcat
    18901 cgggtataga ttctgctttt tttattgcca gcttatctta aacgcattga ggctgtcata
    18961 gtttcggttc ctcctacatc tttgtttata tcaatttata gtataacaca acaagatgat
    19021 atgttcaata taaaagttat ggaatgagac tcatacttcc aattcgatgc cagatttaaa
    19081 ggatatgacg aagttttctt catagactgt aacgctctgg attatcttcc ttagtagcaa
    19141 gcgattagct ttcacaaaat cttctgtttg tagttttaaa aattcatcag gattttctaa
    19201 ctcaacctca aaatatttca ttttacattc cctcatttca tttattgata aattgagttt
    19261 gcaaaaaaga gtggacaatt tttgtc
//
LOCUS       DAVHIZ010000034        19250 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.036, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000034 DAVHIZ010000000
VERSION     DAVHIZ010000034.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19250)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19250)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19250
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.036"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            2..74
                     /locus_tag="VVO18_001361"
     tRNA            2..74
                     /locus_tag="VVO18_001361"
                     /product="tRNA-Asp"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:35..37,aa:Asp,seq:gtc)
     gene            99..171
                     /locus_tag="VVO18_001362"
     tRNA            99..171
                     /locus_tag="VVO18_001362"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:132..134,aa:Lys,seq:ttt)
     gene            177..258
                     /locus_tag="VVO18_001363"
     tRNA            177..258
                     /locus_tag="VVO18_001363"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:211..213,aa:Leu,seq:tag)
     gene            277..349
                     /locus_tag="VVO18_001364"
     tRNA            277..349
                     /locus_tag="VVO18_001364"
                     /product="tRNA-Thr"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:310..312,aa:Thr,seq:tgt)
     gene            372..443
                     /locus_tag="VVO18_001365"
     tRNA            372..443
                     /locus_tag="VVO18_001365"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:404..406,aa:Gly,seq:gcc)
     gene            451..536
                     /locus_tag="VVO18_001366"
     tRNA            451..536
                     /locus_tag="VVO18_001366"
                     /product="tRNA-Leu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:485..487,aa:Leu,seq:taa)
     gene            546..619
                     /locus_tag="VVO18_001367"
     tRNA            546..619
                     /locus_tag="VVO18_001367"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:580..582,aa:Arg,seq:acg)
     gene            635..708
                     /locus_tag="VVO18_001368"
     tRNA            635..708
                     /locus_tag="VVO18_001368"
                     /product="tRNA-Pro"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:669..671,aa:Pro,seq:tgg)
     gene            714..787
                     /locus_tag="VVO18_001369"
     tRNA            714..787
                     /locus_tag="VVO18_001369"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:748..750,aa:Met,seq:cat)
     gene            801..874
                     /locus_tag="VVO18_001370"
     tRNA            801..874
                     /locus_tag="VVO18_001370"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:835..837,aa:Ile,seq:cat)
     gene            885..974
                     /locus_tag="VVO18_001371"
     tRNA            885..974
                     /locus_tag="VVO18_001371"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:921..923,aa:Ser,seq:tga)
     gene            985..1058
                     /locus_tag="VVO18_001372"
     tRNA            985..1058
                     /locus_tag="VVO18_001372"
                     /product="tRNA-Met"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1019..1021,aa:Met,seq:cat)
     gene            1062..1134
                     /locus_tag="VVO18_001373"
     tRNA            1062..1134
                     /locus_tag="VVO18_001373"
                     /product="tRNA-Phe"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1095..1097,aa:Phe,seq:gaa)
     gene            1154..1224
                     /locus_tag="VVO18_001374"
     tRNA            1154..1224
                     /locus_tag="VVO18_001374"
                     /product="tRNA-Gly"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1186..1188,aa:Gly,seq:tcc)
     gene            1260..1333
                     /locus_tag="VVO18_001375"
     tRNA            1260..1333
                     /locus_tag="VVO18_001375"
                     /product="tRNA-Ile"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1294..1296,aa:Ile,seq:gat)
     gene            1340..1427
                     /locus_tag="VVO18_001376"
     tRNA            1340..1427
                     /locus_tag="VVO18_001376"
                     /product="tRNA-Ser"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:1374..1376,aa:Ser,seq:gct)
     gene            complement(1553..2488)
                     /locus_tag="VVO18_001377"
     CDS             complement(1553..2488)
                     /locus_tag="VVO18_001377"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional biotin--[acetyl-CoA-carboxylase]
                     synthetase/biotin operon repressor"
                     /protein_id="HEU5586514.1"
                     /translation="MKSYQAVYQILSKETDYISGEKIAEKLSLSRTAIWKAIKRLEQE
                     GIEIDSIKNRGYKLMNGDLILPEILEENLPIKVSFKPETKSTQLDAKEAIDLGHEANT
                     LYLASYQTAGRGRFQRSFYSPQGGIYMTLHLKPNLPYDKLPSYTLLVAGAVYKAIKNL
                     TLIDVDIKWVNDIYLNNHKIGGILTEAMTSVETGLVTDIIIGVGINFTIKDFPQELKE
                     KAASLFKATAPITRNELIIEIWRAFFETPAEELLYLYKKQSFILGKEVTFTLEQKDYK
                     GLAKDISENGKLLIQCDNGKEIWLNSGEISLNSWK"
     gene            complement(2485..3345)
                     /locus_tag="VVO18_001378"
     CDS             complement(2485..3345)
                     /locus_tag="VVO18_001378"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000959966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEU5586515.1"
                     /translation="MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYIT
                     KGQGKFYYKGKIVDLKKGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALS
                     QISDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELAQLHIMGQLHELMFHLGTIA
                     PNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSP
                     KEYLLYVRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQTPSHTRKEYS
                     QYQLVRKATL"
     gene            3453..5615
                     /locus_tag="VVO18_001379"
     CDS             3453..5615
                     /locus_tag="VVO18_001379"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000538915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosidase"
                     /protein_id="HEU5586516.1"
                     /translation="MGVRIENNLFYVESKNLSLIIENRNGYLLLKHLGKTIKNYKGSN
                     SVYERDHAFSGNPTATNRTFSLDTQRQIFGQHGLGDFRKPTIQVQHSVTEVTDFRFVE
                     AKILKGQNGPQGLPSPHSMDDTETLVLMLEDSKAQLSLTLYYTTFNNDATIASYSKLD
                     NNSNQEVVIHKDFSFMADFPAADYEIVTLQGAYAREKTVRRQQVEQGIFSISSNRGAS
                     GHAQTPALLLCEQGVTEDAGNVFAIQLMYSGNFEAFVQKNQLNEVRVAIGINPENFSW
                     KLAPEEYFETPVALVTHSDQGLTGISHESQNFVLKHIMLSEFSKKERPILINNWEATY
                     FDFQREKLLELADEAKKVGIELFVLDDGWFGNRFDDNRALGDWVVNEEKLGGSLESLI
                     SAIHERGLQFGLWLEPEMISVDSDLYRQHPDWAIQVPDYEHTYSRNQLVLNLANPQVV
                     EYLKSVLDQLLSYHEIDYIKWDMNRNITKLGNGLTYLETQMQSHQYMLGLYELVSYLT
                     EKHSHILFESCSGGGGRNDLGMIRYFPQVWASDNTDAIARLPIQYGSSYLYPTISMGA
                     HVSAVPNHQMGRMTPLETRGHVAMMGNLGYELDLTNLSDEEKATIANQVNLYKELRPV
                     VQLGQQYRLINPDTVSNEAAVQFNYGNQTIVTYVRVLSVVETMETTLKLKDLDEEGLY
                     KLQENGEVYSGAELMYAGLTVILSQGDFLSRQYIFRKL"
     gene            5707..6966
                     /locus_tag="VVO18_001380"
     CDS             5707..6966
                     /locus_tag="VVO18_001380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399433.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU5586517.1"
                     /translation="MEWYKKIGLLATTGLALFGLGACSNYGKSADGTVTIEYFNQKKE
                     MTKTLEEITRDFEKENPKIKVKVVNVPNAGEVLKTRVLAGDVPDVVNIYPQSIELQEW
                     AKAGVFEDLSNKDYLKRVKNGYAEKYAVNEKVYNVPFTANAYGIYYNKDKFEELGLKV
                     PETWDEFEQLVKDIVAKGQTPFGIAGADAWTLNGYNQLAFATATGGGKEANQYLRYSQ
                     PNAIKLSDPIMKDDIKVMDILRINGSKQKNWEGAGYTDVIGAFARGDVLMTPNGSWAI
                     TAINEQKPNFKIGTFMIPGKEKGQSLTVGAGDLAWSISATTKHPKEANAFVEYMTRPE
                     VMQKYYDVDGSPTAIEGVKQAGEDSPLAGMTEYAFTDRHLVWLQQYWTSEADFHTLTM
                     NYVLTGDKQGMVNDLNAFFNPMKADVD"
     gene            6980..7846
                     /locus_tag="VVO18_001381"
     CDS             6980..7846
                     /locus_tag="VVO18_001381"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5586518.1"
                     /translation="MKKVLQKYWAWAFVVIPLLLQAIFFYVPMFQGAFYSFTNWTGLT
                     YNYKFVGLNNFKLLFMDPKFMNAIGFTAIITIAMVVGEIALGIFIARVLNSKIKGQTF
                     FRAWFFFPAVLSGLTVALIFKQVFNYGLPAIGNALHIEFLQTSLLGTKWGAIFAAVFV
                     LLWQGVAMPIIIFLAGLQSIPTEITEAARIDGATSKQVFWNIELPYLLPSVSMVFILA
                     LKGGLTAFDQVFAMTGGGPNNATTSLGLLVYNYAFKNNQFGYANAIAVILFFLIVVIS
                     IIQLRVSKKFEI"
     gene            7860..8693
                     /locus_tag="VVO18_001382"
     CDS             7860..8693
                     /locus_tag="VVO18_001382"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711263.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU5586519.1"
                     /translation="MKQDERKALIGKYILLILGSVLILVPLLATLFSSFKPTKDIVDN
                     FFGFPTNFTWDNFSRLLADGIGGYYWNSVVITVLSLLAVMIFIPMAAYSIARNMSKRK
                     AFTIMYTLLILGIFVPFQVIMIPITVMMSKLGLANTFGLILLYLTYAIPQTLFLYVGY
                     IKISIPESLDEAAEIDGANQFTTYFRIIFPMMKPMHATTMIINALWFWNDFMLPLLVL
                     NRDSKMWTLPLFQYNYAGQYFNDYGPSFASYVVGIISITIVYLFFQRHIISGMSNGAV
                     K"
     gene            8694..8774
                     /locus_tag="VVO18_001383"
                     /pseudo
     CDS             8694..8774
                     /locus_tag="VVO18_001383"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            9051..10493
                     /gene="gtfA"
                     /locus_tag="VVO18_001384"
     CDS             9051..10493
                     /gene="gtfA"
                     /locus_tag="VVO18_001384"
                     /EC_number="2.4.1.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001122330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sucrose phosphorylase"
                     /protein_id="HEU5586520.1"
                     /translation="MPIQNKTMLITYSDSLGNNLKDLYDNLEEHFGDAIGGVHLLPFF
                     PSTGDRGFAPVDYDEVDSAFGDWEDVKRLGERYYLMFDFMINHISRQSKYYKDYQEKH
                     EASEFKDLFLNWDKFWPENRPTQSDVDLIYKRKDRAPKQEIVFEDGSVEHLWNTFGEE
                     QIDLDVTKEVTMEFIRKTIQHLASNGCDLIRLDAFAYAVKKLDTNDFFVEPDIWDLLD
                     KVRDIAAEYGTELLPEIHEHYSIQFKIADHDYYVYDFALPMVTLYTLYSSRTERLAKW
                     LKMSPMKQFTTLDTHDGIGVVDVKDILTDEEIDYASNELYKVGANVKRKYSSAEYNNL
                     DIYQINSTYYSALGDDDVKYFLARLIQAFAPGIPQVYYVGLLAGKNDLKLLEETKEGR
                     NINRHYYSNEEIAKEVQRSVVKALLNLFSFRNRSEAFDLEGTTEIETPTAHSIVIKRQ
                     NKDKSVTAVAEIDLQNQTYRVIENGVEVTF"
     gene            10631..11824
                     /locus_tag="VVO18_001385"
     CDS             10631..11824
                     /locus_tag="VVO18_001385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008293041.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-antigen ligase family protein"
                     /protein_id="HEU5586521.1"
                     /translation="MKSIGFIEKLKGLSSKELILLGIILSIFLPFYLFVVVLCLYIIS
                     LIFTGDMKSILQKMGEHPMLLLFLSYSTVISILAQNWMGLVASVGMFLFTIFFLHYQS
                     ILSHKFFRLILQFVLFGSVLSAAFASLEHFQIVKKFNYAFLSPNMQVWHQNRAEVTFF
                     NPNYYGIICCFCIMIAFYLFTTTKLNWLKVFCVIAGFVNLFGLNFTQNRTAFPAIIAG
                     AIIYLFTTIKNWKAFWLSIGVFAIGLSFLFSSDLGVRMGTLDSSMEERISIWDAGMAL
                     FKQNPFWGEGPLTYMHSYPRIHAPYHEHAHSLYIDTILSYGIVGTILLVLSSVAPVRL
                     MMDMSQESGKRPIIGLYLSFLTVVAVHGIFDLALFWIQSGFIFLLVMCSIPLEHRMLV
                     SDMTD"
     gene            12510..14489
                     /locus_tag="VVO18_001386"
     CDS             12510..14489
                     /locus_tag="VVO18_001386"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000742236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586522.1"
                     /translation="MKKNRVFATAGLVLLAAGVLAACSSSKSSDSSAPKAYGYVYTAD
                     PETLDYLISSKNSTTVVTSNGIDGLFTNDNYGNLAPAVAEDWEVSKDGLTYTYKIRKG
                     VKWFTSDGEEYAEVTAKDFVNGLKHAADKKSEAMYLAENSVKGLADYLSGTSTDFSTV
                     GVKAVDDYTLQYTLNQPEPFWNSKLTYSIFWPLNEEFETSKGSDFAKPTDPTSLLYNG
                     PFLLKGLTAKSSVEFVKNEQYWDKENVHLDTINLAYYDGSDQESLERNFTSGAYSYAR
                     LYPTSSNYSKVAEEYKDNIYYTQSGSGIAGLGVNIDRQSYNYTSKTTDSEKVATKKAL
                     LNKDFRQALNFALDRSAYSAQINGKDGAALAVRNLFVKPDFVSAGEKTFGDLVAAQLP
                     AYGDEWKGVNLADGQDGLFNADKAKAEFAKAKKALEADGVQFPIHLDVPVDQASKNYI
                     SRIQSFKQSVETVLGVENVVVDIQQMTSDEFLNITYYAANASSEDWDVSGGVSWGPDY
                     QDPSTYLDILKTTSSETTKTYLGFDNPNSPSVVQVGLKEYDKLVDEAARETSDLNVRY
                     EKYAAAQAWLTDSSLFIPAMASSGAAPVLSRIVPFTGASAQTGSKGSDVYFKYLKLQD
                     KVVTKEEYEKAREKWLKEKAESNEKAQKELASHVK"
     gene            14556..16052
                     /locus_tag="VVO18_001387"
     CDS             14556..16052
                     /locus_tag="VVO18_001387"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586523.1"
                     /translation="MKKYIFMRVLRSLVSIFLVTTLTYTIIYTLVPRKLIFKQDPNYN
                     KIATTADKRDNYENTVFERMGYIEYYDTKELQEKASSMDSSVTVEANATNKAIYEKYI
                     NQLGHGWTLGEFTESGQFYATREIPIFERVFHFYANLIDIDHTNKIQDPENPDLKRYL
                     RFENDPAIGWSLVGSGTKHKYLLYFNSQFPFVHQNFVNLNLGDSYPTYANTPVLQVIT
                     QGQGQTKTAQVQFPTGKKTSSVNIYSRTYKSPSQADSREVASYGKDDPYTATESNYQY
                     PSMIVSSAITGLIGLVLAYALAVPLGSAMARFKNTWIDSLSTGTLTFLLALPTIALVY
                     IVRLIGSSIALPDSFPILGAGDWRSYVLPAVILGLLGAPVTAIWIRRYMIDLQSQDFV
                     RFARAKGLSEKEISNKHIFKNAMVPLVSGIPGAIIGVIGGATLTETVFAFPGMGKMLI
                     DSVKASNNSMVVGLVFIFTCISIFSRLLGDIWMTIIDPRIKLTEKGGK"
     gene            16052..16978
                     /locus_tag="VVO18_001388"
     CDS             16052..16978
                     /locus_tag="VVO18_001388"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730677.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586524.1"
                     /translation="MSTIDKEKFQFVKRDDFASETIDAPAYSYWKSVFKQFMKKKSTV
                     VMLGILVAIILISFIYPMFSKFDFNDVSKVNDFSVRYIKPNAEHWFGTDSNGKSLFDG
                     VWFGARNSILISVIATVINVVIGVFVGGIWGISKSVDRVMMEVYNVISNIPPLLIVIV
                     LTYSIGAGFWNLIFAMSVTTWIGIAFMIRVQILRYRDLEYNLASRTLGTPTLKIVAKN
                     IMPQLVSVIVTTMTQMLPSFISYEAFLSFFGLGLPITVPSLGRLISDYSQNVTTNAYL
                     FWIPLTTLVLVSLSLFVVGQNLADASDPRTHR"
     gene            16987..18054
                     /locus_tag="VVO18_001389"
     CDS             16987..18054
                     /locus_tag="VVO18_001389"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586525.1"
                     /translation="MTKEKNVILTARDIVVEFDVRDKVLTAIRGVSLELVEGEVLALV
                     GESGSGKSVLTKTFTGMLEENGRIAQGSIDYRGQDLTALSSHKDWEQIRGAKIATIFQ
                     DPMTSLDPIKTIGSQITEVIVKHQGKTAKEAKELAIDYMNKVGIPDADRRFNEYPFQY
                     SGGMRQRIVIAIALACRPDVLICDEPTTALDVTIQAQIIDLLKSLQNEYHFTTIFITH
                     DLGVVASIADKVAVMYAGEIVEYGTVEEVFYDPCHPYTWSLLSSLPQLADDKGDLYSI
                     PGTPPSLYTDLKGDAFALRSDYAMQIDFEQKAPQFSVSETHWAKTWLLHEDAPKVEKP
                     AVIANLHDKIREKMGFAHLAD"
     gene            18065..18991
                     /locus_tag="VVO18_001390"
     CDS             18065..18991
                     /locus_tag="VVO18_001390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001291287.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586526.1"
                     /translation="MSEKLVEIKDLEISFGEGSKKFVAVKNANFFINKGETFSLVGES
                     GSGKTTIGRAIIGLNDTSNGDIIFDGQKINGKKSREQAAELIRRIQMIFQDPAASLNE
                     RATVDYIISEGLYNHRLFKDEEERKEKVQNIIREVGLLAEHLTRYPHEFSGGQRQRIG
                     IARALVMQPDFVIADEPISALDVSVRAQVLNLLKKFQKELGLTYLFIAHDLSVVRFIS
                     DRIAVIYKGVIVEVAETEELFNNPIHPYTQALLSAVPIPDPILERKKVLKVYDPSQHD
                     YETDKPSMVEIRPGHYVWANQAELARYQKGLN"
     gene            complement(19066..>19250)
                     /locus_tag="VVO18_001391"
     CDS             complement(19066..>19250)
                     /locus_tag="VVO18_001391"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5586527.1"
                     /translation="KIINALQLHYSNAKLEATNNLIKLIKRNAFGFRNFENFKKRIFI
                     ALNIKKERTKFVLSRA"
BASE COUNT         5554 a         3483 c         4154 g         6059 t
ORIGIN      
        1 aggtcccgta gtgtagcggt tatcacgtcg ccctgtcacg gcgaagatcg cgggttcgat
       61 tcccgtcggg accgtttaag gtaacgcaag ttattttaga ctcgttagct cagttggtag
      121 agcaattgac ttttaatcaa tgggtcactg gttcgagccc agtacgggtc atatatgcgg
      181 gtttggcgga attggcagac gcaccagatt taggatctgg cgcttaacgg cgtgggggtt
      241 caagtccctt aacccgcatt aagatataac aaatgagccg gcttagctca gttggtagag
      301 catctgattt gtaatcagag ggtcgcgtgt tcaagtcatg tagccggcat ttttagatag
      361 aagaaaacag tgcgaacgta gttcagtggt agaacaccac cttgccaagg tgggggtcgc
      421 gggttcgaat cccgtcgttc gcttagagag gccggggtgg cggaactggc agacgcacag
      481 gacttaaaat cctgcgattg gtaacgatcg taccggttcg attccggtcc tcggcataat
      541 atggagcacc cttagctcaa ctggatagag tacctgacta cgaatcaggc ggttagaggt
      601 tcgactcctc tagggtgcat ttttctattt aactcgggaa gtagctcagc ttggtagagt
      661 acttggtttg ggaccaaggt gtcgcaggtt cgaatcctgt cttcccgatt catggcggtg
      721 tagctcagct ggctagagcg tccggttcat acccgggagg tcgggggttc gatccccttc
      781 gccgctataa tgatcttgtc ggacctttag ctcagctggt tagagctctc ggctcataac
      841 cgagtggtcg taggttcaag tcctacaagg tccatttgaa tattggagga ttacccaagt
      901 ccggctgaag ggaacggtct tgaaaaccgt caggcgtgta aaagcgtgcg tgggttcgaa
      961 tcccacatcc tccttttata ttaacgcggg atggagcagc tcggtagctc gtcgggctca
     1021 taacccgaag gtcgtaggtt caaatcctgc tcccgcaata aggctcggta gctcagttgg
     1081 tagagcaatg gattgaagct ccatgtgtcg gcggttcgat tccgtctcgc gccattttat
     1141 tgatagtatt tatgcgggtg tagtttagtg gtaaaactac agccttccaa gctgttgtcg
     1201 cgagttcgat tctcgtcacc cgctttgaac tttgttcaaa ttaccaagtt ttttaacttg
     1261 ggcgcgtagc tcaggtggtt agagcgcacg cctgataagc gtgaggtcgg tggttcgagt
     1321 ccactcgtgc ccattaattg gagaattact caagaggctg aagaggacgg tttgctaaat
     1381 cgttaggtcg ggtaactggc gcaagggttc gaatccctta ttctccgttt taatgagagt
     1441 ttgtaactct cttttttgtt tttagagaca ataaaacttc agatccgtaa aacttaattg
     1501 aattactaat ctgaagttat ttttatatcg tttatattat aattgtgtta ttttacttcc
     1561 aactattgag agaaatttcg ccactattta gccagatttc ttttccgtta tcacattgaa
     1621 ttaaaagttt tccattttct gagatgtctt tagcaagtcc cttgtagtct ttttgctcta
     1681 gtgtgaaagt gacttctttt cctagaatga atgactgttt tttgtatagg tataatagct
     1741 cttctgctgg tgtttcgaag aaagcacgcc agatttctat gatcaattca ttccttgtta
     1801 taggagctgt agctttaaat aagctggcag ctttttcttt taattcctga gggaagtctt
     1861 taatagtgaa attgatacct actccaataa tgatatctgt gactaagcca gtttctacag
     1921 aggtcattgc ttcagtaagg attcctccaa ttttatgatt gtttagatag atatcattga
     1981 cccattttat gtcgacatct attaaagtta ggttcttaat agctttgtag acagctccag
     2041 ctacaagtag tgtgtaggat ggtaatttgt cataggggag atttggttta agatggagtg
     2101 tcatataaat accaccttgt ggtgagtaga aggaacgttg aaaacggcct cggcctgctg
     2161 tttgatagga agctagatag agggtatttg cttcatggcc taaatcaatt gcttcttttg
     2221 catctagttg tgttgatttt gtttcgggtt taaagctgac tttaattgga agattttctt
     2281 ctagaatctc tggaagaata aggtcaccat tcatcagttt atatcctcta tttttgatac
     2341 tatcaatttc aatgccttct tgttctagtc gcttgatggc tttccaaatt gctgttcggc
     2401 ttagggatag tttttctgcg attttttctc cgctgatata gtcggtttct ttagatagga
     2461 tttggtagac agcttggtag gatttcataa tgttgccttt cttactagtt ggtattgaga
     2521 gtattctttt cttgtatgac ttggagtctg attaaagtat tgtttataag ctttcgaaaa
     2581 atggagtgga tctgaaaaac ctaccgagta tgcaattacc ttgatggact cttgggtatt
     2641 ttcgagaagt tgtctagctc ggtgcattcg aacgtagagt aggtattctt tgggtgataa
     2701 ggtattaaat tctttgaata cgcttgataa gtagcttctg tgaacggata gttcttttgc
     2761 taaatcttga attgtaagtg attgaggata gtggctatca attaatcgtt tgcattcaag
     2821 atagagttgg tgggttgatg aaatattctt ttttttctga ttgggagcaa tagttcccag
     2881 atgaaacatc agttcatgaa gttgtcccat gatatggagt tgagctaatt cacttgattt
     2941 tgtaatctga gcgaagcgga caatgtctga gatgagtttt gcagtagtct gggtatgaca
     3001 agtttcagat tggatgagat aggattgatc agaaatttga gaaagagcaa aataatcagg
     3061 ggatttccct ccagtgattc ctaaccagta gtaggcccaa ggttctttac tatctgcttg
     3121 ataaaaggtt agttcctctg gttttaatag aaagaaatct ccttttttta aatcaacaat
     3181 tttacccttg taataaaatt ttccttgtcc tttagtaatg taatgtagaa cgtatgtatc
     3241 acgaatggct ggaccaaaag agtaattagg tgtgcattcc tcatatccat aaaagcttag
     3301 ggcaaggtcg attgttccag tctggtattc tgaaaaaact aacatgtgct acctcctacc
     3361 taacatttta ccatattctt gagacatttt tctatttcgg aaagcgattt caggtgataa
     3421 aatataatca ataaagtgat gaggtgaagt aaatgggagt taggatagag aataatctat
     3481 tttatgttga gagtaaaaat ctaagtttga ttattgaaaa tcgaaatggc tacttacttt
     3541 tgaaacattt aggaaagact attaagaact ataaaggttc caatagtgtt tatgaacgag
     3601 accatgcctt ttcaggaaat ccaacggcta ctaatcgaac ctttagttta gatactcagc
     3661 gacagatttt tggacaacat ggcttaggag attttaggaa accaaccata caggttcagc
     3721 atagtgtaac tgaagtaaca gactttcgat ttgtagaagc aaagatttta aaaggtcaga
     3781 atggtccaca gggcttacct tctccacata gcatggacga tacagagact cttgtcttaa
     3841 tgttagaaga ttctaaggct caacttagtc tgactttgta ttatactact tttaataatg
     3901 atgcgactat tgctagctac agtaaattag ataataatag taatcaggaa gttgtcatcc
     3961 ataaagattt ttcttttatg gctgattttc cagctgcaga ttacgaaata gtaactctgc
     4021 agggtgctta tgctcgtgaa aagactgtta gacgtcaaca ggtagaacaa ggaatctttt
     4081 cgattagctc aaaccgaggt gcttctggtc atgctcaaac accagctctt ctactatgcg
     4141 aacaaggagt cacagaggat gctgggaatg tgtttgctat tcaactaatg tatagtggca
     4201 actttgaagc ttttgttcaa aaaaatcaat tgaatgaagt tcgggtggct attggcatta
     4261 atccagaaaa cttttcttgg aagttagccc ctgaggaata ctttgaaaca ccggtagctt
     4321 tagtgactca ttcagatcag ggattaactg gtattagtca tgaaagtcag aattttgtac
     4381 tgaagcacat tatgctaagt gaattttcta aaaaagaacg tccaattcta atcaataact
     4441 gggaagctac ttactttgac tttcagagag aaaaactgtt agagttagca gatgaagcta
     4501 agaaagttgg cattgaactt tttgtattag atgatggttg gtttggcaat cgttttgatg
     4561 ataatcgtgc tttaggtgat tgggttgtta atgaggaaaa actgggtgga agtctagaaa
     4621 gtctgatttc agctatccat gaaagaggtt tgcagtttgg actttggtta gaacccgaaa
     4681 tgatttctgt agatagtgat ttgtatcgtc aacatcctga ctgggctatt caggttcctg
     4741 attatgagca tacttattct cggaatcaat tagtacttaa tcttgccaat cctcaggtag
     4801 tagaatactt gaaaagtgtc ttagatcaac tcctatctta tcatgagatt gattacatta
     4861 aatgggatat gaaccgcaat atcactaagc tagggaatgg attaacttat ctagagacac
     4921 agatgcaatc tcatcagtac atgctggggc tttacgaact cgtttcttat ctgacagaga
     4981 agcacagcca tattctcttt gagtcctgct ctggtggtgg tggacgaaat gatcttggta
     5041 tgatacgcta tttcccacaa gtctgggcta gtgataatac tgatgccatt gcacgtttac
     5101 caattcaata cggttcatcc tatctctatc caaccatttc tatgggggct catgtgtcag
     5161 cagtaccgaa tcatcagatg ggacgaatga caccattaga aacacgtggc catgtagcaa
     5221 tgatgggaaa tttgggctat gagcttgatt tgacaaattt atcagatgaa gagaaagcta
     5281 cgattgctaa tcaggtgaac ttgtataaag aattacgacc agtagttcag ttaggacagc
     5341 agtatagact aattaatcct gatactgtat ccaatgaagc agctgtacaa tttaattacg
     5401 gaaatcaaac gattgtaacc tacgttcgcg ttttatctgt tgtagagacc atggaaacaa
     5461 ctttaaaatt aaaagatttg gatgaagagg gactatataa attacaggaa aatggcgaag
     5521 tttactcagg tgcagaacta atgtatgcgg gcttaactgt tatcttatcc caaggagatt
     5581 ttttgagtag acagtatatt tttagaaaac tatgatatgt actgacccca aaagttagat
     5641 ttattctgtc taacttttgg ggtgcagttc aataagggtg tataaattta taaaggaggc
     5701 tttctaatgg aatggtataa aaaaatcgga cttcttgcaa ctacaggttt agctttgttt
     5761 gggctcggcg cttgctccaa ctatggtaaa tctgcggatg gcacagtgac catcgagtat
     5821 ttcaaccaga aaaaagaaat gaccaaaacc ttggaagaaa tcactcgtga ttttgagaag
     5881 gaaaacccta agatcaaggt caaagtcgtc aatgtaccaa atgctggtga agtattgaag
     5941 acacgcgttc tcgcaggaga tgtgcctgat gtggtcaata tttacccaca gtccatcgaa
     6001 ctgcaagaat gggcaaaagc aggtgttttt gaagatttga gcaacaaaga ctacctgaaa
     6061 cgcgtgaaaa atggctacgc tgaaaaatat gctgtaaacg aaaaagttta caacgttcct
     6121 tttacagcta atgcttatgg aatttactac aacaaagata aattcgaaga actgggcttg
     6181 aaggttcctg aaacctggga tgaatttgaa cagctagtca aagatatcgt tgctaaagga
     6241 caaacaccat ttggaattgc aggtgcagat gcttggacac tcaatggtta caatcaatta
     6301 gcctttgcga cagcaacagg tggaggaaaa gaagcaaatc aataccttcg ttattctcaa
     6361 ccaaatgcca ttaaattgtc ggatccgatt atgaaagatg atatcaaggt catggacatc
     6421 cttcgcatca atggctctaa gcaaaagaac tgggaaggtg ctggctatac cgatgttatc
     6481 ggagccttcg cacgtgggga tgtcctcatg acaccaaatg ggtcttgggc gatcacagcg
     6541 attaatgaac aaaaaccgaa ctttaagatt gggaccttca tgattccagg aaaagaaaaa
     6601 ggacaaagct taaccgttgg tgcgggagac ttggcatggt ctatctcagc caccaccaaa
     6661 catccaaaag aagccaatgc ctttgtggaa tatatgaccc gtccagaagt catgcaaaaa
     6721 tactacgatg tggacggatc tccaacagcg atcgaaggag tcaaacaagc aggagaagat
     6781 tcaccgcttg ctggtatgac cgaatatgcc tttacggatc gtcacttggt ctggttgcaa
     6841 caatactgga ccagtgaagc agacttccat accttgacca tgaactatgt cttgaccggt
     6901 gataaacaag gcatggtcaa tgatttgaat gccttcttta acccgatgaa agcggatgtg
     6961 gattaggagt agagagacta tgaaaaaagt attacaaaaa tattgggcat gggcttttgt
     7021 ggtcatcccc ctcttgttac aagcaatttt cttctatgtg ccgatgtttc aaggagcctt
     7081 ttacagtttt accaactgga caggattgac ttataactac aaatttgtcg gcttaaacaa
     7141 ctttaagctc ctcttcatgg atccaaaatt catgaatgcg attggcttta ccgcaatcat
     7201 tacgattgcc atggtggttg gtgagattgc actcgggatc ttcattgcgc gtgtcttgaa
     7261 ttctaaaatc aaaggccaaa ccttcttccg tgcttggttc ttcttcccag ctgttttatc
     7321 tggtttgaca gtggctttga tcttcaagca agtcttcaac tacggtcttc cagcgattgg
     7381 gaatgccctt catattgaat ttctccaaac cagtctttta gggactaagt ggggagcaat
     7441 ctttgcggct gtctttgtcc ttctttggca aggggtggct atgcccatca tcatcttcct
     7501 agctggtttg caatctattc caactgagat tacagaggca gcaaggattg atggtgcgac
     7561 gagcaagcaa gttttctgga acattgaatt gccttacttg ctaccaagtg tctctatggt
     7621 ctttatccta gccctaaaag gtgggctgac tgcctttgac caagtctttg ccatgaccgg
     7681 tggtggtcca aacaatgcca caacctcact tgggctcttg gtttataact atgcctttaa
     7741 aaacaaccaa ttcggttatg ccaatgccat tgccgtaatc ttgttcttct taattgtagt
     7801 gatttcgatc atccaattga gagtatctaa gaaatttgaa atttaagagg agaagcatga
     7861 tgaaacaaga tgaaagaaaa gccctgattg gcaaatacat tctattgatt ctaggatcgg
     7921 ttctgatttt agtgccgctc cttgctaccc tctttagttc cttcaaaccc actaaggata
     7981 ttgtagataa tttctttggc tttccaacca acttcacatg ggacaacttt agccgtctct
     8041 tagctgatgg gattggaggc tattattgga actctgtcgt catcactgtc ttgtctttac
     8101 ttgcagtaat gatctttata cctatggcag cctactccat cgctcgcaat atgagtaaaa
     8161 gaaaagcctt taccatcatg tataccctct taatcctcgg aatcttcgta cctttccaag
     8221 tcatcatgat tccgattacg gttatgatga gtaaactcgg tttggctaat acctttggtt
     8281 tgatcttact ctacttgacc tatgcgattc cacagaccct ctttctctat gttggctata
     8341 tcaaaatctc gattccagaa agtctggatg aagcagcaga gatcgatggg gctaatcaat
     8401 ttacaaccta tttccgcatc atcttcccaa tgatgaaacc gatgcatgcg acaaccatga
     8461 tcatcaatgc cctttggttc tggaatgact tcatgttgcc actccttgtc ttgaaccggg
     8521 attccaaaat gtggactctg cctttgttcc aatacaacta cgcaggccaa tatttcaacg
     8581 actacggacc aagctttgcc tcttacgtgg tcggcattat cagtatcacc attgtctatc
     8641 tcttcttcca acgccatatc atttcaggaa tgagcaacgg ggcagtgaag taatactcaa
     8701 tgaaaatcaa agagcaaact aggaagctag ccgcaggttg ctcaaaacac tgttttgagg
     8761 ttgtggatga aactgacgaa gtcagtaacc atacctacgg taaggtgaag ctgacgtggt
     8821 ttgaagagat tttcgaatag tataagaaga gctcatggaa tctatagtct ttgacacaga
     8881 ggaagagttc agcttgttga taattctatg tagaaaacaa gaaagtagta ctttgtttat
     8941 cacagtctat attagtacga gtttgatgat aaatagagat ttaaaatgaa ttttatttat
     9001 gaagccagat catatgagac ttggcttcaa ttagaaaaag gagagtaatg atgccaattc
     9061 aaaataaaac catgttgatt acctattctg atagccttgg aaataatctt aaagacttat
     9121 atgataattt ggaagagcat tttggagatg ctattggagg agttcacctt ttaccatttt
     9181 tcccatcaac aggtgatcgt ggatttgcgc cagttgacta cgacgaagtg gactcagctt
     9241 ttggtgattg ggaggatgtt aagcgtttag gtgagagata ttatcttatg tttgatttta
     9301 tgattaatca tatttctcgt caatccaagt attataagga ctatcaagaa aaacatgaag
     9361 ccagtgaatt taaagatctc tttttaaact gggataagtt ttggccagaa aaccgtccga
     9421 cacagtctga tgtagattta atttacaagc gtaaggatcg tgcaccaaag caagagattg
     9481 tgtttgaaga tggttcagtg gaacatttgt ggaatacctt tggtgaggag cagattgatc
     9541 ttgatgtgac caaagaagta actatggaat ttatccgtaa gaccattcag cacttggcaa
     9601 gtaatgggtg tgatttgatt cgtctagatg cctttgctta tgcagtgaag aaattggata
     9661 ctaatgattt ctttgtggaa ccagatattt gggatttatt ggacaaagtt cgagatatcg
     9721 ctgctgagta tgggacagag cttttacctg agattcatga acactattcg attcagttta
     9781 aaatagcaga ccatgattac tatgtttatg attttgctct tccaatggtg acactttata
     9841 ctctttacag ttccagaaca gagcgtttgg ctaagtggtt aaagatgagc ccgatgaagc
     9901 aatttacgac gctagatacc catgatggga ttggagtagt agatgtcaag gatatcctga
     9961 ccgatgagga gattgactat gcttcaaatg aactctataa ggttggagcc aatgtcaaac
    10021 gtaagtactc tagtgccgag tataacaact tagatatcta ccaaatcaat tcaacctact
    10081 attcagcgct tggagatgat gatgtcaagt attttctcgc tcgtctaatt caagcttttg
    10141 ccccaggtat tcctcaggtt tactatgtgg gtctattagc aggcaagaat gacttgaaat
    10201 tattagaaga aactaaagaa ggtcgaaata ttaatcgtca ttactatagc aacgaggaaa
    10261 tagcaaaaga agtgcaacga tctgttgtga aggcccttct caatctattt tctttccgta
    10321 accgttcaga agcctttgat ctagaaggga ctactgagat agagacacca acagctcaca
    10381 gcattgtaat caaacgtcaa aataaagata agtccgtaac agcagtagca gaaattgatt
    10441 tgcaaaatca gacttatcgg gtaattgaga atggagttga agtaacattt tgaagccttg
    10501 atatggtgga taaaataggg tttttatttt ggaaaacgtt tcctttgttt tcaaattgct
    10561 aaaaaagtgg tacaatatag gatagcttac tattatctga atcagctgat ttggagagaa
    10621 aggattcatt ttgaaatcaa taggctttat tgaaaagctg aaggggttgt ctagtaaaga
    10681 gctgatttta ttgggaatta tcctaagtat ctttttaccc ttttatcttt ttgtagttgt
    10741 actctgttta tatattatca gtttgatttt tacaggagac atgaaaagta ttcttcagaa
    10801 aatgggggag catccgatgc tgcttctttt tcttagctat agtactgtta tatccattct
    10861 tgcacaaaat tggatgggtc ttgtggcttc agtaggaatg tttctattta ctattttctt
    10921 tttgcactat cagtcgattt tatcccataa attctttcga ttgattttgc agttcgtctt
    10981 gtttggtagt gtcttgtcag ctgcttttgc cagtttagaa catttccaaa ttgtgaagaa
    11041 atttaactat gcttttcttt cacccaatat gcaggtgtgg catcagaacc gggcagaagt
    11101 gaccttcttt aatcctaatt attatggaat tatttgttgt ttctgtatta tgattgcttt
    11161 ctatctgttt acaacgacca agttgaattg gttgaaagta ttctgtgtga ttgcaggctt
    11221 tgttaatctc tttggtttga actttactca aaatcgaact gcctttcctg ctattatcgc
    11281 tggagcaatt atctatctct ttacgactat taaaaactgg aaggcctttt ggcttagtat
    11341 tggggtcttc gcgattggtt tgagtttcct cttttctagt gatttgggag ttcgaatggg
    11401 tactttagac tcttctatgg aagaacgcat ttctatctgg gatgctggga tggccttgtt
    11461 taagcaaaat cctttttggg gtgaagggcc attgacctat atgcactctt atcctcggat
    11521 acatgctcct tatcatgaac atgcccacag tctttatatt gatacgattc tgagttacgg
    11581 aattgtgggt accattttat tagttttgtc ttctgttgct cctgttcgct tgatgatgga
    11641 tatgagtcag gagtcgggga aacgtccgat tatcggcctt tatctatctt tccttacagt
    11701 ggttgctgtg cacggaattt ttgacttggc tctcttctgg attcagtcag gctttatttt
    11761 cttgctagtt atgtgcagta ttccattgga gcatcgaatg ttggtatcgg acatgacgga
    11821 ttaagtttta taagtttgaa atcttctacc ttgggtagga gattttttta tacgatgggc
    11881 atgtcgtgca tctgaggtgt aagtcttctg tagggatcca ctaccggtga atacaatagc
    11941 gctccccaag cctgactatc gtgaggtagc ggattaaaat ggtctgggga tagatcgttt
    12001 taagtctgac gcaggaaata agaattgtca gagaaagcaa tagtgaaatc gtaggctatg
    12061 aatagaaacg tgatagcgag gagcatatag tggataaggt agcgagaaat tttaaagtat
    12121 aaaagatagt cttaatctat atatgtaaat cacaaaagta attgaattcg gaataaggtt
    12181 ggtgtgaaaa gacatagtaa actgaatctt gaatactaga atgatacttc tacaatattg
    12241 ttataattta atttgaattc caaaatcaca ttgttccgtc cgtatttcat tttactgtat
    12301 gtcttcctaa actccaaagt ttctgcgtca aatttcctat tttcactgta gtctttgaca
    12361 cttcgaacga caatttgaat catatattca aaaaaaatga aaaatttgtg ccaacaagcc
    12421 taaatattct gaaaatttgt ttgattttta atggataatg tgatataatg gttgtcaatc
    12481 tataattcac ataaacagag gagtagaaaa tgaaaaaaaa tcgtgtattt gctacagcag
    12541 gtcttgtttt attagcagca ggtgtacttg cagcatgcag ttcttcaaaa tcatctgatt
    12601 catcagcccc taaagcttat ggctatgttt atacagcaga cccagaaacc ttggactacc
    12661 tgatttcaag taaaaatagt acaacagtag tgacttcaaa tgggattgat ggtttattca
    12721 ctaacgataa ttacggtaat cttgctcctg cagttgcaga ggattgggaa gtctctaagg
    12781 atggtttgac ctacacttat aagattcgta aaggggttaa atggtttacc tctgatggag
    12841 aagaatatgc agaggtgacg gctaaagatt tcgtgaacgg tttaaaacac gcagcagata
    12901 aaaaatcaga agctatgtat ttagctgaaa attcggttaa aggcttggca gattatctat
    12961 caggaacttc aacagatttt tcaacagttg gtgtcaaggc ggttgatgat tatacgttac
    13021 aatacacttt gaaccagcct gaaccgttct ggaactctaa gttgacctat tctattttct
    13081 ggcctctgaa tgaagaattc gaaacatcaa aaggaagcga ttttgctaaa ccaacagatc
    13141 cgacatcctt gctttataat ggtccattct tgttgaaagg gttgactgca aaatcttctg
    13201 tagagtttgt aaaaaatgag caatattggg ataaagaaaa tgtccaccta gatactatca
    13261 atctagctta ctatgatgga tcagatcagg agtcgctaga gcgtaacttc actagtggag
    13321 cttatagtta tgcccgtctt taccctacca gctccaacta ttctaaggtt gcagaagaat
    13381 acaaggacaa tatctattac acacaatcag gctctgggat tgctggtctg ggtgtgaata
    13441 ttgatcgcca aagttacaac tatacttcta aaactacaga ttcagagaaa gtagctacta
    13501 agaaggcatt gcttaacaaa gatttccgtc aagccttgaa ttttgctctt gatcgctcag
    13561 cttactcagc tcaaatcaat ggtaaagatg gagcagcttt agcagttcgt aatttatttg
    13621 taaaaccaga ctttgtttca gctggtgaga agacctttgg tgatttagtc gctgctcaac
    13681 ttcctgctta tggtgatgag tggaaaggtg tgaatttagc tgatgggcag gatggtttat
    13741 tcaatgctga caaggccaag gcagagtttg cgaaagctaa gaaagcttta gaagcagacg
    13801 gcgttcagtt tcctattcat ctggacgttc cagtagacca agcatcaaaa aactacatat
    13861 ctcgtattca gtcctttaaa caatctgtag aaacagttct tggtgttgaa aatgtcgttg
    13921 ttgatattca acaaatgaca agtgatgaat tccttaatat tacttactat gctgccaatg
    13981 cttcatctga ggattgggat gtatcaggag gagtttcatg ggggccagac tatcaagacc
    14041 catctactta cctggatatt ttaaaaacaa ctagcagtga aactacaaaa acatatttag
    14101 gatttgataa tccaaatagc ccttcagtag ttcaagttgg tttgaaagaa tacgataaat
    14161 tagttgatga agctgccaga gagacaagcg acttgaatgt ccgttatgaa aaatatgcag
    14221 cggctcaagc atggttgaca gatagttcac tctttattcc tgctatggct tcttctggtg
    14281 cagcaccagt gctttcacga attgttccat ttactggagc ttctgcgcaa acaggctcta
    14341 aggggtcaga tgtttacttc aaatatttga aattacaaga taaagtggtg actaaggaag
    14401 agtatgaaaa agctcgtgaa aaatggttga aagaaaaagc tgaatcaaat gagaaagctc
    14461 aaaaagaatt ggcaagtcat gtgaagtaaa taatttctaa tagaactttc tctccatgag
    14521 gagaaggttc ttttgggatt tttaaaggaa ataatatgaa aaaatatatt tttatgcgtg
    14581 ttttgcggtc attggtttcg attttcttag taacgacttt gacctacacg attatctata
    14641 ccttggttcc tcgaaaattg attttcaagc aggatcctaa ctataataaa attgcgacaa
    14701 cggctgataa acgtgataac tatgaaaata ctgtgtttga gcgtatgggc tacattgagt
    14761 attacgatac taaagagttg caagaaaagg caagtagcat ggattcttct gtaacagtag
    14821 aagcaaatgc gaccaataaa gctatttatg aaaagtacat caatcaatta ggtcatggtt
    14881 ggactttggg agaatttact gaaagtggtc aattctatgc tactcgtgaa attccaattt
    14941 ttgaacgtgt ttttcacttc tatgctaact tgattgacat tgatcataca aataaaatcc
    15001 aagaccctga aaatccagac ttgaaacgct accttcgttt tgaaaatgat ccagctatcg
    15061 gatggtcatt ggtcggttca ggaactaaac ataaatatct cttgtacttt aacagtcagt
    15121 tcccatttgt tcatcaaaac tttgtgaact tgaatttagg tgactcttac ccaacctatg
    15181 ctaatacacc agttcttcag gttattactc aaggtcaagg acaaaccaaa actgcccaag
    15241 ttcagttccc aacaggtaag aaaacgtctt ctgtaaatat ttactcaaga acctacaagt
    15301 cacctagtca ggctgactct cgtgaagtag ctagctatgg gaaagatgat ccttatacag
    15361 cgactgaaag taattaccaa tatccatcta tgattgtcag ctctgctatt actggtttga
    15421 ttggtttggt tcttgcctat gctcttgccg tgccacttgg ttcagccatg gctcgtttca
    15481 agaacacttg gattgatagc ctctcaacag ggactttgac cttcttgctt gctcttccaa
    15541 cgattgcctt ggtttacatc gttcgattga ttggatcatc tattgccctt ccagattcat
    15601 tccctatctt gggagctgga gattggcgtt cttacgtttt accagcagtc atccttggtt
    15661 tgttgggtgc tcctgttaca gccatttgga ttcgtcgtta catgattgac ttgcaatctc
    15721 aagactttgt tcgtttcgct cgtgcaaaag gtttgtctga aaaagaaatt tcaaacaaac
    15781 acatctttaa aaatgccatg gttccgctgg tttcaggaat tcctggtgcc attattgggg
    15841 ttatcggtgg tgcaaccctt actgaaacag tcttcgcctt cccaggtatg ggtaaaatgt
    15901 tgattgactc tgtaaaagca tctaataact ctatggtcgt tggtcttgtc ttcatcttta
    15961 catgtatttc tatcttctca cgtcttttgg gagatatttg gatgactatt attgacccac
    16021 gtattaaatt gactgagaaa ggaggcaaat aatgtctaca atcgataaag aaaaatttca
    16081 gtttgtaaaa cgtgacgatt ttgcctctga aactattgat gcgccagcat attcttactg
    16141 gaaatcagtg tttaaacaat ttatgaagaa aaaatcaact gtagtcatgt tgggaatctt
    16201 ggtagccatc attttgataa gtttcatcta cccaatgttt tctaagtttg atttcaatga
    16261 tgtcagcaag gtaaacgact ttagtgttcg ttatatcaag ccaaatgcgg agcattggtt
    16321 cggtactgac agtaacggta aatcgctctt tgacggtgtc tggttcggag ctcgtaactc
    16381 catcctcatt tctgtgattg cgacagtgat taacgtggtt atcggtgttt ttgtcggtgg
    16441 tatttggggt atttcaaaat cagttgaccg tgtcatgatg gaagtttaca acgtcatctc
    16501 aaacatccca cctcttttga ttgttattgt cttgacttac tcaatcggag ctggattctg
    16561 gaatctgatt tttgccatga gcgtaacaac atggattggt attgccttca tgatccgtgt
    16621 gcaaatcttg cgctatcgtg acttggaata caacttggcg tcacgtactt tgggaacacc
    16681 aaccttgaag attgttgcca aaaatatcat gcctcaattg gtatctgtta ttgtgacaac
    16741 catgactcaa atgcttccaa gctttatctc atacgaagcc ttcttgtctt tcttcggtct
    16801 tggattaccg attacagtgc caagtttggg tcgtttgatt tcggattatt cacaaaacgt
    16861 aacaaccaat gcttacttgt tctggattcc attgacaacc cttgtcttgg tatccttgtc
    16921 ccttttcgta gttggtcaaa acttagcgga tgctagtgat ccacgtacac atagatagga
    16981 gtagaaatga caaaagaaaa aaatgtaatt ttgactgctc gcgatattgt cgtggaattt
    17041 gacgttcgtg acaaagtatt gacagccatt cgcggcgttt cccttgaact agtcgaagga
    17101 gaagtattag ccttggtagg tgagtcagga tcaggtaaat ctgttttgac aaagaccttc
    17161 acaggtatgc tcgaagaaaa tggtcgtatt gcccaaggta gtattgacta ccgtggtcag
    17221 gacttgacag ctttatcttc tcacaaggat tgggaacaaa ttcgtggtgc taagattgcg
    17281 actatcttcc aggacccaat gactagtttg gaccccatta aaacaattgg tagtcagatt
    17341 acagaagtta ttgtaaaaca ccaaggaaaa acagctaaag aagcgaaaga attggccatt
    17401 gactacatga ataaggttgg cattccagac gcagatagac gttttaatga atacccattc
    17461 caatattctg gaggaatgcg tcaacgtatc gttattgcga ttgcccttgc ctgccgacct
    17521 gatgtcttga tctgtgatga gccaacaact gccttggatg taactattca agctcagatt
    17581 attgatttgc taaaatcttt acaaaacgag tatcatttca caacaatctt tattacccac
    17641 gaccttggtg tggtggcaag tattgcggat aaggtagcgg ttatgtatgc aggagaaatc
    17701 gttgagtatg gaacggttga ggaagtcttc tatgaccctt gccatccata tacatggagt
    17761 ctcttgtcta gcttgcctca gcttgctgat gataaagggg atctttactc aatcccagga
    17821 acacctccgt cactttatac tgacctgaaa ggggatgctt ttgccttgcg ttctgactac
    17881 gcaatgcaga ttgacttcga acaaaaagct cctcaattct cagtatcaga gacacattgg
    17941 gctaaaactt ggcttcttca tgaggatgct ccaaaagtag aaaaaccagc tgtgattgca
    18001 aatctccatg ataagatccg tgaaaaaatg ggatttgccc atctggctga ctaggaggaa
    18061 ggaaatgtct gaaaaattag tagaaattaa agatttagaa atttccttcg gtgaaggaag
    18121 taagaagttt gtcgcggtta aaaatgctaa cttctttatc aacaagggag aaactttctc
    18181 gcttgtaggt gagtccggta gtgggaaaac aactattggt cgtgctatca tcggtctaaa
    18241 tgatacaagt aatggagata tcatttttga tggtcaaaag attaatggta agaaatcgcg
    18301 tgaacaagct gcggaattga ttcgtcgaat ccagatgatt ttccaagacc ctgccgcaag
    18361 tttgaatgaa cgtgcgactg ttgattatat tatttctgaa ggtctttaca atcaccgttt
    18421 atttaaggat gaagaagaac gtaaagagaa agttcaaaat attatccgtg aagtaggtct
    18481 tcttgctgag cacttgactc gttaccctca tgaattctca ggcggtcaac gtcaacgtat
    18541 cggtattgcc cgtgccttgg tcatgcaacc agactttgtt attgcagatg agccaatttc
    18601 agccttggac gtttctgtac gtgcccaagt cttgaacttg ctcaaaaaat tccaaaaaga
    18661 gctcggcctg acctatctct tcatcgccca tgacttgtcg gttgttcgct ttatttcaga
    18721 tcgtatcgca gttatttaca agggtgttat tgtagaggtt gcagaaacag aagaattgtt
    18781 taacaatcca attcacccat atactcaagc cttgctttca gcggtaccaa tcccagatcc
    18841 aatcttggaa cgtaagaagg tcttgaaggt ttacgatcca agtcaacacg actatgagac
    18901 tgataagcca tctatggtag aaatccgtcc aggtcactat gtttgggcga accaagccga
    18961 attggcacgt tatcaaaaag gactaaacta gtaatggttt tataatttcc atgtcaattt
    19021 ttatggaaat taggctcttt gtcaactgta gtgggttgaa gtcagctaag ctcgagaaag
    19081 gacaaatttc gtcctttctt ttttgatgtt caaagcgata aaaatccgtt ttttgaagtt
    19141 ttcaaagttt cgaaaaccaa aggcattgcg cttgataagt ttgatgagat tattggtcgc
    19201 ttccagtttg gcattagaat agtgtagttg aagggcgttg ataatctttt
//
LOCUS       DAVHIZ010000035        19233 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.037, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000035 DAVHIZ010000000
VERSION     DAVHIZ010000035.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 19233)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 19233)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19233
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.037"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(45..1385)
                     /locus_tag="VVO18_001392"
     CDS             complement(45..1385)
                     /locus_tag="VVO18_001392"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000275284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5586528.1"
                     /translation="MYIFWIILYTLITNGLEIVIFFKVDGIGLTFERIFKAFLLKILL
                     AFVFVMIGYMIGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRG
                     VSYFVLPFLGQEQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRREILDTGFQK
                     SLTKINWIMGAYYLVIQSLSYFEYEQGIQSTTVRHLILVFYLLFFMGVIKKLDTYLKD
                     KLHDRLDQEQVLRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIK
                     EVYDLVLKDSSKKLQDNKYDLGRLVNVRDRALKSLLAGKFIKAREKDIVFNVEVPEEI
                     QVEGMRLLDFLTIVSILCDNAIEASAEAGQPHVSIAFLKSGAQETFIIENSIKEEGID
                     ISEIFSFGVSSKGEERGVGLYTVMKIVESYPNASLNTTCQDQVFRQVLTMIPTE"
     gene            complement(1398..2135)
                     /locus_tag="VVO18_001393"
     CDS             complement(1398..2135)
                     /locus_tag="VVO18_001393"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001219153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586529.1"
                     /translation="MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLL
                     AEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQDPYALIVFVTTHSEFMPLSFRYQ
                     VSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
                     LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKL
                     LFFPNGGSCLIARYKVREVSEAINNLH"
     gene            complement(2140..2478)
                     /locus_tag="VVO18_001394"
     CDS             complement(2140..2478)
                     /locus_tag="VVO18_001394"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000682119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586530.1"
                     /translation="MKHMIIQTQKTVYKVNIDDIYYIQTHPTKAHTVQIVTEKASFNM
                     LQNLSNLENQCGETLMRCHRNCLVNLDKLKSIDFQERILFLGEEGQYAVRYARRRYRE
                     IRQKWLKEGE"
     gene            2754..3083
                     /locus_tag="VVO18_001395"
     CDS             2754..3083
                     /locus_tag="VVO18_001395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864062.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase BlpT"
                     /protein_id="HEU5586531.1"
                     /translation="MTDTDPIKRAHTLITDLNKAYQACKQASADDVRFQEQLNSILGF
                     LAKTETVDNRFLIELEKFYQTSSLLMGLSALDPDAPTRAAWRAYDRFHFDQVKTKLIL
                     NENQRAN"
     gene            complement(3251..4300)
                     /locus_tag="VVO18_001396"
     CDS             complement(3251..4300)
                     /locus_tag="VVO18_001396"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399209.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586532.1"
                     /translation="MKDLFLKRKQAFRKECLCYLRYVLNDHFVLFLLVLLGFLAYQYS
                     QLLQHFPENHWPILLFVGITSVLLLLWGGIATYMEAPDKLFLLVGEEEIKLHLKRQTG
                     ISLVFWIFVQTLFLLLFAPLFLVMGYGLPVFLVYVLLLGVGKYFLFRQKASKFFTETG
                     LDWDYVISQESKRKQVLLRFFALFTQVKGISNSVKRRAYLDFILKVVQKVSGKIWQNL
                     YLRSYLRNGDLFALSLRLLLLSLLAQVFIEQSWIATAVVVLFNYLLLFQLLALYHAFD
                     YQYLTQLFPLDKGQKEKGLQEVVRGLISFVLLVELVVGLITFQEKLALLALLGAGLVL
                     LVLYLPYQVKRQMQD"
     gene            complement(4297..5028)
                     /locus_tag="VVO18_001397"
     CDS             complement(4297..5028)
                     /locus_tag="VVO18_001397"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586533.1"
                     /translation="MLEIKNLTGGYVHVPVLKDVSFTVESGQLVGLIGLNGAGKSTTI
                     NEIIGLLAPYSGSININGLTLQGDATSYRKQIGYIPETPSLYEELTLREHIETVAMAY
                     GIEQKVAFERVEPLLKMFRLEQKLDWFPVHFSKGMKQKVMIICAFVVDPSLFIVDEPF
                     LGLDPLAISDLIQLLEVEKQKGKSILMSTHVLDSAEKMCDAFVILHKGEVRAKGNLLQ
                     LREAFDMPEASLNDIYLALTKEEDL"
     gene            5096..5506
                     /locus_tag="VVO18_001398"
     CDS             5096..5506
                     /locus_tag="VVO18_001398"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006150090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HIT family protein"
                     /protein_id="HEU5586534.1"
                     /translation="MSDCIFCKIIAGEIPASKVYEDEQVLAFLDISQVTLGHTLVVPK
                     EHYRNLLEMDATSASQLFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTVFHTHVHL
                     VPRYSADDDLKIDFIAHEPDFDKLAQVAETIKNA"
     gene            5516..5803
                     /locus_tag="VVO18_001399"
     CDS             5516..5803
                     /locus_tag="VVO18_001399"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000777751.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586535.1"
                     /translation="MKLSNLLLFAGAAAGSYLVTKNRQTITDEVLNTTDRVQAIKDDV
                     DIIQNSLQIINQQKELIKEYQEDLTYKFKVLEKDIQTRLAVIKEMQGTEDK"
     gene            5965..6159
                     /locus_tag="VVO18_001400"
     CDS             5965..6159
                     /locus_tag="VVO18_001400"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586536.1"
                     /translation="MHHNLGNSYSIKIKKQTRKLGTDCSKHRFKVVDRTDEVSNHTHD
                     KPTLTWFEEIFEEYHSPFHN"
     gene            complement(6481..7617)
                     /gene="dnaJ"
                     /locus_tag="VVO18_001401"
     CDS             complement(6481..7617)
                     /gene="dnaJ"
                     /locus_tag="VVO18_001401"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001066288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaJ"
                     /protein_id="HEU5586537.1"
                     /translation="MNNTEFYDRLGVSKNASADEIKKAYRKLSKKYHPDINKEPGAED
                     KYKEVQEAYETLSDDQKRAAYDQYGAAGANGGFGGAGGFGGFNGAGGFGGFEDIFSSF
                     FGGGGSSRNPNAPRQGDDLQYRVNLTFEEAIFGTEKEVKYHREAGCRTCNGSGAKPGT
                     SPVTCGRCHGAGVINVDTQTPLGMMRRQVTCDVCHGRGKEVKYPCTTCHGTGHEKQAH
                     SVHVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLYVVVSVEASDKFEREGTTIFYNLN
                     LNFVQAALGDTVDIPTVHGDVELVIPEGTQTGKKFRLRSKGAPSLRGGAVGDQYVTVN
                     VVTPTGLNDRQKVALKEFATAGDLKVNPKKKGFFDHIKDAFDGE"
     gene            complement(7822..8175)
                     /locus_tag="VVO18_001402"
     CDS             complement(7822..8175)
                     /locus_tag="VVO18_001402"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000115730.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586538.1"
                     /translation="MSVNKNNLSDIADYHEKIKFFEELFNLDYNPTEMLVTVERNGNV
                     IYKEFTEVAVGKSKYDYTSVFKDVMIYFSDHICQELHLYKTQDPHYNKFEFDLAKRSL
                     KITTRDNTTIFISNE"
     gene            complement(8188..10011)
                     /gene="dnaK"
                     /locus_tag="VVO18_001403"
     CDS             complement(8188..10011)
                     /gene="dnaK"
                     /locus_tag="VVO18_001403"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002946936.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="molecular chaperone DnaK"
                     /protein_id="HEU5586539.1"
                     /translation="MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKN
                     GEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAE
                     DYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDK
                     EEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKEN
                     GIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFD
                     DLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKS
                     VNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK
                     SQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDK
                     NGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNE
                     VDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQ
                     GLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK"
     gene            complement(10491..11015)
                     /gene="grpE"
                     /locus_tag="VVO18_001404"
     CDS             complement(10491..11015)
                     /gene="grpE"
                     /locus_tag="VVO18_001404"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000046028.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide exchange factor GrpE"
                     /protein_id="HEU5586540.1"
                     /translation="MAQDIKNEEVEEVQEEEVVETAEETTPEKSELDLANERADEFEN
                     KYLRAHAEMQNIQRRANEERQNLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKG
                     LGMVQESLIHALKEEGIEEIAADGEFDHNYHMAIQTLPADDEHPVDTIAQVFQKGYKL
                     HDRILRPAMVVVYN"
     gene            complement(11042..12076)
                     /gene="hrcA"
                     /locus_tag="VVO18_001405"
     CDS             complement(11042..12076)
                     /gene="hrcA"
                     /locus_tag="VVO18_001405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011999912.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="heat-inducible transcriptional repressor HrcA"
                     /protein_id="HEU5586541.1"
                     /translation="MVTERQQDILNLIIDIFTKTHEPVGSKALQESINSSSATIRNDM
                     AELEKQGLLEKAHTSSGRMPSVAGFQYYVKHSLDFDRLAENEVYEIVKAFDQEFFKLE
                     DILQEAANLLTDLSGCTVVALDVEPSRQRLTAFDIVVLGQHTALAVFTLDESRTVTSQ
                     FLIPRNFLQEDLLKLKSIIQERFLGHTVLDIHYKIRTEIPQIIQRYFTTTDNVIDLFE
                     HIFKEMFNENIVMAGKVHLLNFANLAAYQFFDQPQKVALEIREGLREEQMQNVRVADG
                     QESCLADLAVISSKFLIPYRGVGILAIIGPVNLDYQQLINQVNVVNRVLTMKLTDFYR
                     YLSSNHYEVH"
     gene            complement(12240..12749)
                     /locus_tag="VVO18_001406"
     CDS             complement(12240..12749)
                     /locus_tag="VVO18_001406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001088691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2812 domain-containing protein"
                     /protein_id="HEU5586542.1"
                     /translation="MNSRVEFRIFTIVDLDKEEEYLHEMHLKGWRYRTSRFGLFYFDQ
                     CQPDDVIYRIYDSRFLKKYKHELQDFRDRGWELIGAGSCSILRKSSSDLLPEDQVYMS
                     KGLKWEVMRSRLRSCTATFLGGLVVCTSLFREDLSMSFFLIFVLYAFLISYLIHGYFR
                     LKRKYRVDE"
     gene            13357..15690
                     /locus_tag="VVO18_001407"
     CDS             13357..15690
                     /locus_tag="VVO18_001407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEU5586543.1"
                     /translation="MVEFIKSKKEMSEEDIKANFITPAIVSKGWKNGEHIAYEEYFTD
                     GRIEVRGDKARRKEGKKSDYSLYYQFGTRIAIVEAKDNKHSVRAGLQQAIEYGEILDV
                     PFVYSSNGDGFIEHDRITREERELELDEFPTREELFSRMTKEKGLTYEITEAISTPYY
                     TDAFSMKTPRYYQQIAINRTIETVARGQKRVMFVMATGTGKTFMAFQIIHRLRKAGLA
                     KRVLFLADRNILVDQTMAEDFKPFEKVMTKITPKLLTAPEKLNSFEIYLGLYQQLTGE
                     DGTETHYQKFDKDFFDLIVIDEAHRGSAKENSNWRKIIDYFSSATQIGMTATPKETKN
                     ASNTEYFGEPIYTYSLKQGIEDGFLAPYRVMRVNLDVDVDGYRPETGKVDTNGQLIED
                     RYYGRKDFDKTIVIDDRTQRVAKFVSDYMKQSNARFDKTIVFCVDIDHAERMRAALVK
                     ENLDLVQEDYRYVMQVTGDNAEGKAQLDNFMDVNSNFPAIVTTSKLLTTGVNAKTCRL
                     IVLDSNIQSMTEFKQIIGRGTRLYPQKGKEFFTIIDFRNVTNLFADPDFDGDPVKVLE
                     TGAKTVSGSTPGFVDEEGDPVEKYIVTDKQVTILNSTVQVLDENGKLITESLTDYTRK
                     NILGSYATLNDFITVWHTADKKKLILDELYKKGVYLDAIRESEGISEQEIDDFDLLLK
                     LAYGQKELTKTERINKLKQSGYLYKYSEEARAVLEILLNKYMDKGIGELESIETLKLP
                     EFQIYGGTFKIINTYFGDKKRYLQAIKELEQELFTVA"
     gene            15703..17166
                     /locus_tag="VVO18_001408"
     CDS             15703..17166
                     /locus_tag="VVO18_001408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000029054.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SAM-dependent DNA methyltransferase"
                     /protein_id="HEU5586544.1"
                     /translation="MSITSFVKRIQDITRNDAGVNGDAQRIEQMSWLLFLKIYDSREM
                     VWELEEDEYESIIPEELKWRNWAHAQNGERVLTGDELLDFVNNKLFKELKELEITSNM
                     PIRKTIVKSAFEDANNYMKNGVLLRQVINVIDEVDFNSPEDRHSFNDIYEKILKDIQN
                     AGNSGEFYTPRAATDFIAEVLNPKLGESMADLACGTGGFLTSTLNRLSSQRKTSEDTK
                     KYNTAVFGIEKKAFPHLLAVTNLFLHEIDDPKIVHGNTLEKNVREYTDDEKFDIIMMN
                     PPFGGSELETIKNNFPAELRSSETADLFMAVIMYRLKENGRVGVILPDGFLFGEGVKT
                     RLKQKLVDEFNLHTIIRLPHSVFAPYTGIHTNILFFDKTKKTEETWFYRLDMPDGYKN
                     FSKTKPMKSEHFNPVRDWWENREEILEGKFYKSKSFTPSELAELNYNLDQCGFPKEEE
                     EILDPFELIQNYQAERATLNHKIDNVLADILQLLEDK"
     gene            17166..18734
                     /locus_tag="VVO18_001409"
     CDS             17166..18734
                     /locus_tag="VVO18_001409"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000187251.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU5586545.1"
                     /translation="MTPEQLKASILQRAMEGKLVPQNPNDEPASELLKRIKAEKEKLI
                     SEGKIKRDKKETEIFRGDDGKHYGKFADGSTQEIDVPYDIPDTWEWVRFSTLVEIVRG
                     GSPRPIKDYLTSEVDGINWIKIGDTEKGEKYINNVKEKIKKSGLNKTRFVKKGTFLLT
                     NSMSFGRPYILNVDGAIHDGWLAISNYENSLNKDYLFYILSSNVVYSQFLSLISGAVV
                     KNLNSDKVASILIPLPPLAEQQRIIEAIESALEKVDEYAESYNRLEQLDKEFPDKLKK
                     SILQYAMQGKLVEQDPNDESVEVLLEKIRAEKQKLFEEGKIKKKDLDISIVSQGDDNS
                     YYGNKDETTSYPIYEIPEAWRYIKFASLVNFRIGKTPPRSEATFWGTEIPWVSISDMP
                     ISGYVTNTRESISKLALKSKKIDISPKGTLLMSFKLSIGKVAILDIPATHNEAIISIF
                     PYANKENIIRDYLMIFLPLISTLGDSKDAIKGKTLNSTSISELLIPISNHEEMKRIIS
                     KVDLLFQKVSQLFE"
     gene            complement(18682..19227)
                     /locus_tag="VVO18_001410"
     CDS             complement(18682..19227)
                     /locus_tag="VVO18_001410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001104691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU5586546.1"
                     /translation="MNWVVIKIKDIFSMNTGLSYKKGDLSINNKGVRIIRGGNIKPLE
                     FSLLDNDYYIDTQFISSEQVYLKHNQLITPVATSLEHIGKFARIDKDYDGVVAGGFIF
                     QLTPFESSEIISKFLLFNLSSPLFYKQLKAITKLSGQALYNIPKTTLSELLIPLAPFE
                     EQELITQKVEKLFEKVNQLWK"
BASE COUNT         6142 a         3831 c         3616 g         5644 t
ORIGIN      
        1 aaaataagac cgagtaacaa gaactctcgg tcttattttt ttcatcattc tgtaggtatc
       61 atagtaagca cctgacgaaa gacttgatct tgacaggtag tatttaaact ggcattggga
      121 taactttcca caatcttcat aacggtatag agaccgacac ctctctcctc ccctttagaa
      181 ctaactccaa aggagaagat ttcagaaata tctatgccct cttctttgat ggaattttcg
      241 atgatgaagg tctcctgtgc tccacttttt aaaaaggcaa ttgaaacatg aggttgaccg
      301 gcctctgcac tcgcttcaat agcattatca caaaggatag acacaatggt tagaaaatca
      361 agcagtctca tcccctcaac ctgaatctct tcaggaactt cgacattaaa gacaatgtcc
      421 ttttctctag cttttataaa ttttccagct aggagacttt tgagggcacg atcccgaaca
      481 ttcaccaatc ggccaaggtc atatttattg tcctgcaatt ttttactaga atcctttaag
      541 accaagtcat agacctcttt tatctgctcc atatcctcct cttcaatacc cagacgtaaa
      601 cttgtcaaga ggttggtgta gtcatggcga aaactcctta cttccttgta aagttcctct
      661 atatgccgac tatagcgttc catatctcta tagcgcaaga cctgctcttg gtccagtcta
      721 tcatggagtt tgtccttcaa ataggtatcc aatttcttga taacccccat aaaaaatagg
      781 aggtaaaaca ctaggatgag atggcgaaca gtcgttgatt gaataccttg ctcatattca
      841 aagtaagaca gactttgtat caccaaatag taagccccca ttatccagtt aatcttagtc
      901 agggactttt gaaaacctgt atctagaatc tcccttctca aactagtaaa atcatagtcc
      961 aaccatttca aaaaggctag agaaatgaag aaattgaaaa ttattataca taacccagta
     1021 aatgagtagc catcatatac ttgctcttgt cccaaaaatg gaagcacaaa ataggagact
     1081 cctctataaa agagattcac caatatcatt ggaaagagac cataaaagaa aaggagtttt
     1141 ttaggaagcc ctcttaacaa taagaaagac aagcctatgc catacaaggg ttccataaaa
     1201 taagataggt aaacatttcc tatcatatag ccaatcatta caaaaacaaa ggccaacagt
     1261 atcttcaaaa gaaaggcctt aaaaatcctc tcaaaagtga gaccaattcc atctacctta
     1321 aagaaaatga caatttctag cccattagta ataagtgtat acaatataat ccaaaaaata
     1381 tacataaatt tcctagttca gtgtaagtta ttaatagcct cagacacttc cctgacctta
     1441 taacgcgcga tcagacagct tccaccattg ggaaagaaaa ggagtttttc tttcttatcc
     1501 aaatgcacca catttgcagg attgatgaga aaagagcgat ggcactgcaa gagacggggt
     1561 tcctgcttaa aaacctcctc taaactcgcc gtaaattcta gcctgtccgt cttggtatag
     1621 agaataacac gatggggtct tggggatgtt tcgagatagt aaacctcttt gaaaggatat
     1681 tggaattggg caaattttga tttaaagtaa aagcaatctt ccgccagact tttactatct
     1741 tgactattgg catagaggag ggctgtctcg atacgagatt caaactcctc tgccgaaagg
     1801 gccttatcaa tgtagtccaa agctgacact tggtagcgaa aggacagagg cataaactcc
     1861 gagtgagtcg tcacaaagac gattagggca taagggtctt gttcccgaat ctttctagcc
     1921 acttccagtc ccttcatctc ttcatttcga atctcaatat ccaaaaagaa tagctgatgg
     1981 gcccccttct catgcacctc tgccagcagt tggtccggct tgccaaatac ctcaaaagag
     2041 ctaggaatga tatgatgtgc tttcaaaagt ttctcaatcg tcgtttcaat tctagtctgt
     2101 tgggaaaaat catcttctaa aacaaatatt ctcatcttct tactctccct ctttcaacca
     2161 tttttgacgt atttctctat agcgacgtct ggcatacctg acagcatatt gaccttcttc
     2221 tccgagaaaa aggattcttt cttgaaaatc aatcgatttt aatttatcaa gattaaccaa
     2281 acaatttcga tgacatctca tcaaagtttc cccacattgg ttctcaagat tacttaaatt
     2341 ttgaagcata ttaaaactag ctttttctgt aacaatctgt acggtatggg ctttagttgg
     2401 atgtgtttgg atatagtaga tatcgtcgat gtttacttta tagactgttt tctgtgtctg
     2461 aataatcata tgtttcattg gattctcctc ctaagaaaag aataacagaa aagatctagc
     2521 ccaagcacac ccaatcctaa acagtctttg aaaactccta aaaggattat tttctacaac
     2581 atcatgatga gcttacaact attttatcat aaaattcact cagcgcaatt caagacattt
     2641 caatgacaat taaagatttg aataaaaaaa aagaattaaa agtgataaac taacagtatc
     2701 aaaacacagt tgccagaagt aagactggca cccagattaa aggaggcatt cccatgacag
     2761 atacagaccc catcaaaaga gctcatactt tgattactga cttaaacaaa gcctaccaag
     2821 catgcaaaca ggcaagcgct gacgacgtcc gctttcagga gcaattaaac tctattcttg
     2881 gttttctagc caagactgaa acagtggata atcgattctt gattgaacta gaaaaatttt
     2941 accagacttc cagtcttctc atgggactca gcgctcttga tccagatgct ccaactcgcg
     3001 ccgcttggcg ggcctatgac cgcttccact ttgaccaagt caagaccaag ttaatactca
     3061 atgagaatca aagagcaaac taggaagcta gccgcaagct gtacttgagt acggtaaggc
     3121 gacgctgacg tggtttgaag agattttcga agagtataag tctctacgga ccaaccatta
     3181 tcctgtagta acaaaaaaga agctgagaca aactgaactc aacttctttt ttagtgtcgt
     3241 atcagcaatg ttagtcctgc atctgacgtt ttacctgata aggcaaatac aagactagta
     3301 aaaccaaacc agctcctagt aaggctagaa gggctagttt ttcttggaag gtaatcaacc
     3361 caacaactaa ttccacaagt aaaacaaaac tgatcaatcc tcgaactacc tcctgtaagc
     3421 ctttttcctt ttgccccttg tccagcggaa agagttgggt caaatactgg tagtcaaagg
     3481 catgatagag ggccagcaac tggaaaagca agaggtagtt aaagagaact accactgctg
     3541 tcgcaatcca agattgctcg ataaagacct gcgccagcaa agaaagcaag agcagacgga
     3601 gactaagggc aaaaaggtct ccatttcgca aataagaacg cagatagaga ttttgccaaa
     3661 tcttcccaga caccttctga acaaccttta gaataaagtc cagataggca cgacgcttga
     3721 cgctgtttga aattcccttg acctgcgtaa agagggcaaa gaaacgaagc aagacttgct
     3781 tacgcttgct ttcttgggaa atgacatagt cccaatccag tccagtttca gtgaaaaatt
     3841 tgctggcctt ttgacgaaag aggaaatatt ttcctacccc caataaaagc acatagacca
     3901 gaaaaacagg caagccataa cccatgacta aaaacaaggg cgcaaataac agcaagaaga
     3961 gggtctgaac aaaaatccaa aagactaggg aaatgccggt ttgacgcttg agatggagct
     4021 tgatttcctc ttctccaact aagagaaaga gcttgtctgg agcctccata taggtggcaa
     4081 ttcctcccca aagtaaaagt aaaacagacg taattcctac aaacaaaagg ataggccaat
     4141 gattttcagg aaaatgttgt aagagttgac tgtactggta ggctagaaag cccaacagga
     4201 caagcaggaa caagacaaag tggtcattga gcacatagcg cagataacaa agacactcct
     4261 tacgaaaggc ctgctttctc tttaaaaaca agtctttcat agatcctcct ctttggtcag
     4321 agccaagtaa atatcattca aactagcctc aggcatatca aaggcttcac gtagttgcag
     4381 gagattgcct ttggcacgca cctctccctt gtgaagaatg acaaaggcat cacacatctt
     4441 ttccgccgaa tccagcacgt gggtactcat gagaatagac ttgccctttt gcttctccac
     4501 ttccaaaagc tgaatcaaat cagaaatagc cagcggatca agaccaagga aaggctcatc
     4561 cacgatgaaa agacttggat ccaccacaaa agcacagata atcatgacct tctgcttcat
     4621 cccttttgaa aaatgaacag ggaaccagtc taatttctgt tccaaacgga acatttttaa
     4681 caagggctct actcgttcga aagccacttt ttgctcaata ccgtaagcca tagcaaccgt
     4741 ttcgatatgc tctctgaggg tcaattcctc atacagacta ggcgtctcag gaatgtagcc
     4801 aatctgcttg cggtagctag tcgcatctcc ttgcagagtc aggccattga tattgatgga
     4861 gccactataa ggtgccaaca gaccgataat ctcattgatc gtcgttgatt tcccagcacc
     4921 attgagacca atcaaaccga ccaactgccc actttcaaca gtaaaggaca catctttcaa
     4981 aacaggaaca tgaacatagc cacctgtcag gtttttaatt tctaacatat tttctccaaa
     5041 tctggtataa tgtagctata ttatatcaaa attcagtaca gtagaggtag attttatgtc
     5101 agattgcatt ttttgtaaaa tcatcgcagg ggaaattcct gcttcaaaag tatatgaaga
     5161 tgagcaggtc cttgcctttc ttgatatctc tcaagtaaca ctaggacaca ccttggtcgt
     5221 gccaaaagaa cactatcgca atcttttgga gatggatgct acgagcgcca gccaactctt
     5281 tgcccaagta ccaaaagtag ctcaaaaagt catgaaagtc actaaggctg ctggtatgaa
     5341 tatcatttcc aactgtgaag aagtcgctgg tcaaacagtt tttcatactc acgttcacct
     5401 tgtgcctcgc tacagtgctg acgatgacct caagattgat tttatcgccc acgaaccaga
     5461 ctttgacaaa cttgctcaag tcgctgaaac catcaaaaac gcttaaggag ttgctatgaa
     5521 attatccaac ctactgctat ttgcaggagc tgcagccgga agttatctgg ttacaaaaaa
     5581 tcgccaaacc atcacagatg aagtcttgaa taccactgac cgcgttcaag ctatcaagga
     5641 cgatgtggat attatccaaa acagcctgca aatcattaac cagcaaaaag aacttatcaa
     5701 ggaataccaa gaagacttga cttacaagtt taaggtcttg gaaaaggata tccagactag
     5761 actagctgtg ataaaagaaa tgcagggaac tgaagataag taaaaagagc ccgacggctc
     5821 ttttttaaaa cgtaaacaag ttatagtgaa ttgaatttag aatagcacat catagtttct
     5881 aaagcattgt tagagattac tttaaaatcc tcttatcaat ttgttcatat tctatttcaa
     5941 tctactatat atatcccatc aactatgcat cataatttag gtaactcata ctcaataaaa
     6001 atcaaaaagc aaactagaaa gctaggcaca gactgctcaa aacaccgttt taaggttgtg
     6061 gatagaactg acgaagtcag taaccatacc catgacaagc cgacgctgac gtggtttgaa
     6121 gaaatttttg aagagtatca ttcaccattt cacaactaaa tcgaagactt tctgccgtaa
     6181 tgaaaacacc tgaaacagct tggtttcagc tgtccggaaa ctttaagact taggttcaaa
     6241 gtttaggtat ggaacttcga aggaggtcgc taccgtccgt cattacttag gaaagtctta
     6301 aaaaatctat aaagtaaaaa gagcccgaca gctctttttg tttatactca atgaaaatca
     6361 aaaagcaaac taggaaacta gccacgggct gctcaaaaca ctgttttgag gttgtagata
     6421 cgactcacat atatacggca aggcaacgct gacgtggttt gaagagattt tcgaagagta
     6481 ttattctcca tcaaaggcat cttttatatg gtcaaagaag ccttttttct ttggatttac
     6541 tttcaagtca ccagcagtcg cgaattcttt caaggctact ttttggcggt cgttcaagcc
     6601 tgtcggtgtt acgacattaa cagtaacgta ttggtcacca actgcaccgc cacgaaggct
     6661 cggtgccccc ttactacgta ggcggaattt cttaccagtc tgagttccct ctggaataac
     6721 caattcaaca tcaccgtgaa cagttggaat atctactgta tcaccaagag ccgcttggac
     6781 aaagttgagg ttgagattgt agaagatagt cgttccttca cgttcaaact tgtcgctagc
     6841 ttctacagaa actactacat acaagtcacc ataaggtcca ccgttaaagc ctgcttcacc
     6901 ttgaccagcg aggcgaattt gttgacctgt ttccacacca gcagggattt tcacatgtac
     6961 gctatgagct tgtttctcat gacctgttcc atgacaggtt gtacatggat atttgacttc
     7021 ttttcctcga ccgtgacaga catcacaggt tacttggcga cgcatcatac caagaggagt
     7081 ctgcgtatcg acgttaatga caccagcgcc atgacagcgt ccacaagtga ctggacttgt
     7141 ccctggctta gcaccagagc cattacatgt acgacagcca gcttcacgat gatacttaac
     7201 ttccttctca gttccgaaga tagcttcttc aaatgtcaaa ttgacacgat actggagatc
     7261 atctccttgg cgaggagcgt ttggattgcg cgaagaaccg cctccgccga agaaacttga
     7321 gaaaatatcc tcaaaaccac cgaagccacc tgccccattg aaaccaccga aaccaccagc
     7381 tccaccaaaa ccaccattgg cgcctgcagc accatactgg tcataggcag cacgtttttg
     7441 gtcgtcactc aaagtctcat aggcttcttg aacttccttg tacttgtcct cagcaccagg
     7501 ctccttgttg atatctgggt gatatttttt ggaaagctta cgataagcct ttttgatctc
     7561 gtctgccgaa gcgttttttg acacccccag acgatcataa aattcagtat tgttcataca
     7621 agataccaag accgtaaaat tcgactgaaa aataggaaat ctgacgctgg agcgacgctc
     7681 ctagacagat ttctcttttt tccgagaatt taggtcgggt tcaattcctt tcttttatat
     7741 tgatgagata atactccagc cactcggccc tatccctttt taccgaaaaa cagaggctgg
     7801 gttgcaacct ctgtggttag attattcatt tgaaataaaa atggttgtat tatctctagt
     7861 agtaatcttc aaagaccttt tagctaaatc aaactcaaat ttattatagt gtgggtcttg
     7921 tgttttatat aggtgtaact cctgacatat atgatccgaa aagtaaatca taacatcttt
     7981 aaacacagaa gtgtagtcat atttactctt accaacagct acttctgtaa attctttata
     8041 aatgacattt ccatttcttt ccacagtcac cagcatttct gttggattat aatccaaatt
     8101 aaataattct tcaaaaaact ttatcttttc atgataatct gcaatgtcag aaagattatt
     8161 tttattaaca ctcataacac tagcccctta tttttcagta aactctccgt ctacgacgtc
     8221 atcgcctgcg tttcctgttg cttgtgcgcc ttctgctcct tcttgagctt gttgcgctgc
     8281 tgcggcttgt tcgtagagtt tcacagcaag gccttgagct ttttcgttca acgcttcaag
     8341 tttcgctttc atgtcgtcca agttgttgtc ttcttgagct ttcttaaggt catcaagggc
     8401 agcttgggca gcgtcacgtt ctgcgtcgaa gcctttacct tcagtttcct tgattgtctt
     8461 ttcagtcgca aagattgctt ggtctacttc attacgaagg tctacttctt ctttacgttt
     8521 cttatcagct tcagcgtttg cttcggcatc tttcatcatg cggtcgattt cttcgtcagt
     8581 caaacctgag ttcgattgga tgacaatagt ttgttctttt tgagttccaa ggtctttggc
     8641 cttaacagac acgataccgt tcttgtcgat gtcaaatgtt acttcgattt gaggaattcc
     8701 acgaggtgca gctgggatat cagtcaattg gaagcgtcca agagtcttgt tatctgctgc
     8761 cattgggcgt tcaccttgaa gaacgtggat atcaacggct ggttggttgt ctgctgctgt
     8821 tgagaagact tgtgatttag atgttgggat tgtagtgttg cgatcgataa gttttgtaaa
     8881 tactccaccc attgtttcga taccaagtga caatggcgtt acatcaagaa ggacaacgtc
     8941 cttgacatca ccagtaatca caccaccttg gatagccgca cccatagcaa ctacttcatc
     9001 agggtttact gatttgtttg gttctttacc agtttcagct ttaacagctt caacaacggc
     9061 agggatacga gttgaaccac caacaaggat aacttcgtcg atttctgaca agctcaaacc
     9121 tgcatctgaa agggcttgac gaactggaac ttttgtacgt tcaacaaggt cacgagtcaa
     9181 atcgtcaaat ttcgcacgag tcaaagtcat ttccaagtga agaggtccag cctcacctgc
     9241 agtgataaat ggcaagctga tttgtgttga agttacacca gaaaggtctt tcttcgcttt
     9301 ttcagccgca tctttcaaac gttgcattgc catcttgtca gtagacaagt cgataccgtt
     9361 ttctttcttg aattctgcta ccaagtggtc aatgattttt tggtcaaagt cgtcaccacc
     9421 aagtttgttg tcccctgcag ttgacaatac gtcgaagaca ccgtcaccca attcaaggat
     9481 agagacgtcg aatgtaccac caccaaggtc aaataccaag attttttctt ctttgtcagt
     9541 cttgtccaaa ccataagcaa gagctgctgc agttggttcg ttaacaatac gttctacttc
     9601 aagaccagca attttaccag cgtcttttgt tgcttgacgt tgagcgtcgt tgaagtaagc
     9661 cggaactgtg ataacagctt tggttacttt ctcaccaagg tagtcttcag cgtagccttt
     9721 caagtattga aggatcatag ctgagatttc ttgtggagtg tattcttttc catttgcaga
     9781 aactttttca gaagttccca tcttagattt gatagagata actgtatctg ggtttgtgac
     9841 tgcttgacgt tttgcagcat caccaacgat aatttctccg tttttgaatg agactacaga
     9901 tggagttgtg cggtttcctt ctgggtttgc gatgattttg ctttcagttc cttcaagaac
     9961 tgcaactgct gagtttgttg tacctaagtc aataccgata attttagaca tgtgtttttc
    10021 tccttgttag ttaattttct atttttcttt ttgatactct tcttaagtgg cgacgccgtc
    10081 agagcttgac tttgtcaata tctttgacta aactttgagc ctaaggtctc aaaatttgcg
    10141 caaatagcgc cacagcgaag agtatcgtct ttggttcgct tcgctcacta ttacaaagcc
    10201 aaacatattt tatctttctt catagtttat tgtcgtttcg gacaagtttt ctattctgta
    10261 aattgcgaca cgaggagtcg aaatcgattt tatttcgacg acgagttagt aaggaagcta
    10321 gacaaacgcc atagcgattg ccgttttctg acgagttgct ttagctaccg tcagaattgc
    10381 cgaatcgaac acgccctaag ctctgagtaa aaaagataga ttttcttgtg ttcatcgaac
    10441 acttcgtcaa tctcctattt ttactgcgag ctttttacgg gctttgtatc ttagttatac
    10501 accactacca ttgctgggcg taggatgcgg tcatggagtt tgtagccttt ttgaaagact
    10561 tgggcgatgg tatctactgg gtgttcatcg tctgctggga gagtttggat ggccatatgg
    10621 tagttatggt caaattcgcc atctgctgcg atttcttcaa ttccttcttc tttcaaagcg
    10681 tgaatcaagc tttcttgcac catccccaag cccttcttca catcatctgt caaaccttca
    10741 actgcaagtg cacgctcaag gttgtcaaga gatggtaaga ttgcttttgc caagtcctgg
    10801 ctacgataac gttgcaagtt ttgacgttct tcattggcac ggcgttggat attttgcatt
    10861 tctgcatgag cgcgaagata tttgttttcg aactcatctg cacgttcatt tgccaagtcc
    10921 aactcagact tttcaggagt tgtttcttca gctgtttcca caacttcctc ttcttgaact
    10981 tcttctactt cttcattttt tatatcttgg gccatgttcg cctcctttaa tgatttcaat
    11041 cttaatgtac ttcataatga ttactgctga ggtagcggta aaaatctgtc aacttcatag
    11101 tcaaaacacg gttgaccaca ttgacttgat tgattagctg ttggtaatcc agattaactg
    11161 gaccgataat ggctagaatt ccaactcccc gataaggaat gaggaactta ctactaatca
    11221 ccgctaggtc agctaaacag gactcttgac cgtctgcaac acgaacattt tgcatctgtt
    11281 cctcacgcaa cccctcacga atctccaagg ccaccttttg cggttggtca aagaactgat
    11341 aggctgctag attggcaaaa ttcaagagat ggaccttgcc cgccatcaca atgttttcgt
    11401 tgaacatttc cttaaagatg tgttcaaaga gatcgatgac attatccgtt gttgtaaagt
    11461 aacgctggat aatctgcgga atctccgtcc gaatcttgta gtgaatatct aaaacggtgt
    11521 gaccgaggaa acgttcctga atgatgctct tcagtttcag caaatcctcc tgcaagaagt
    11581 tccttggaat cagaaactga ctagtaaccg ttcgcgactc gtctagggta aataccgcca
    11641 aggctgtatg ttgccccaaa acaacgatat caaaggctgt caaacgttgc ctgctcggct
    11701 caacatccag tgccactacc gtacagccac tcaggtctgt tagtaagtta gcagcctctt
    11761 gcagaatatc ctccaatttg aagaattcct gatcaaaggc tttgacaatc tcatatacct
    11821 cattttcagc cagccggtca aaatccagtg agtgtttcac atagtactga aaaccagcaa
    11881 cacttggcat ccgaccgctt gaagtatgag ccttctcaag caacccttgt ttttctagtt
    11941 ccgccatgtc attacgaatg gttgcactgc tagagttaat agactcttgc aaggcttttg
    12001 atccgacagg ttcgtgcgtt ttggtaaaga tgtcaataat cagatttaaa atatcctgct
    12061 gacgctctgt aaccatctca tcactcctct ctgtctgatc aattagcact caatgcatcc
    12121 aagtgctaac ttatgattct attatacacc cttagaagag aatgtcaaga caaaaactca
    12181 aaaaattagc actcttttat caagagtgct aaaaatcaat ctgaagacct agaaccttgc
    12241 tattcatcta ctcggtattt cctttttagt ctgaaataac catgaattag ataagaaatc
    12301 agaaaagcat ataaaacaaa aataagaaag aaagacatag aaagatcctc tctaaacaaa
    12361 ctcgtacaaa caacaagacc acctaagaaa gtagctgtac aggaacgaag tctagatcgc
    12421 ataacttccc atttgagccc cttactcata tagacttgat cctctggaag taaatcagaa
    12481 gacgatttac gaagaatcga acaagaacct gctcctatca attcccaacc tctatctcta
    12541 aaatcttgca gttcatgctt atatttttta agaaatctag aatcatagat acggtagatg
    12601 acatcgtctg gttgacattg gtcaaaatag aacaaaccaa aacgactcgt tctatacctc
    12661 caacctttca aatgcatctc atgtaaatat tcttcttcct tgtccaaatc aacaatggtg
    12721 aaaatccgaa attctactct gctattcatt gtcttacccc aaaattagaa aacatgcctg
    12781 gcgttattta ttagataatt ctttccactt ttgactcaat ctccaaaaaa tataagaaat
    12841 ctgaatcgca aaaactatca ataaaaccca atctattatg aaaatcaaaa acactttcca
    12901 actgaaagaa ctacctccag tgacaaactt tgagaaaaac ggcagtagag ctaaaaagag
    12961 aagtaaaata ggaagcatcc gcattgttaa aatccgtttg gcataaaaaa atctttattt
    13021 aaacgaaaat attatagcaa aatttacgcc agtttttgaa cggctgatgt agatatttta
    13081 tactttcaaa atgtttaaat gtgattattt atttttgaaa aatagctcac cagcccgact
    13141 gaaagtgctt atagaatgat aataagtcgc ctgccgaaaa cagcggaaaa tagcggtgtt
    13201 atgcggagat aatctgacgc gatgcgaaag tatattgcat acttattttc aacaatttag
    13261 cagagtattt ttataagtgt gatataatag aagtataatt tgttctgata gtttatttta
    13321 tggagaagta gatttttaga atgcggaggg ttcaatatgg ttgagtttat aaagtctaag
    13381 aaagaaatga gtgaggagga tattaaagca aatttcatca ctcctgctat tgtatccaaa
    13441 ggatggaaaa atggtgagca tatcgcttac gaagaatact tcactgatgg tcgaattgag
    13501 gttagaggag ataaggctcg tcgtaaagaa ggaaaaaaat cagactattc actgtattac
    13561 caatttggaa ctcgaattgc aattgttgag gcaaaggata ataaacacag cgttcgagca
    13621 ggattacaac aagctattga atatggagag attttagatg ttccatttgt ttattcttca
    13681 aatggtgatg gctttattga acacgaccgt atcacgagag aagaacgtga gctggagtta
    13741 gacgaattcc ctactcgtga agaattattt tctcgtatga cgaaggaaaa aggattgacg
    13801 tacgaaatta cagaagctat ctcaactcca tactatacag acgccttctc aatgaaaacg
    13861 ccacgctatt atcagcaaat agctatcaac cgtactattg aaacagttgc cagaggacaa
    13921 aaacgagtaa tgtttgtgat ggcaacagga acggggaaaa cgttcatggc ttttcaaatt
    13981 attcatcgcc ttcgaaaagc tggtttggct aaacgagttt tattcttagc ggatagaaac
    14041 atcttagtag accaaacgat ggctgaagac tttaagccat tcgaaaaggt aatgacgaaa
    14101 attacaccaa aacttttgac tgctcctgaa aaattaaatt cttttgaaat ttatctaggg
    14161 ctttatcagc aactaactgg tgaagatgga actgaaacac attatcaaaa atttgacaaa
    14221 gacttctttg atttaatcgt aattgatgaa gcgcaccgtg gttcagctaa ggaaaacagt
    14281 aactggcgta agataattga ttatttcagt tctgcgacac agattgggat gaccgctact
    14341 cctaaagaaa ccaagaatgc ttccaatacg gaatactttg gtgagccaat ctatacttat
    14401 agtttaaaac agggaatcga ggatggtttt ttggctccat atcgtgttat gagggttaat
    14461 ttagatgtgg atgtggatgg ttatcgtcca gaaactggaa aagttgatac taacggacaa
    14521 ttaatagaag ataggtacta cggcaggaaa gattttgata aaaccattgt cattgatgat
    14581 agaacgcaaa gagttgccaa gtttgtttct gattatatga agcaaagcaa tgcacgattt
    14641 gataaaacaa ttgttttttg tgttgatatt gaccatgccg agcgaatgcg tgctgcactt
    14701 gtaaaagaga atctagactt agtccaagaa gactatcgtt atgtcatgca agtaactggt
    14761 gacaacgctg aaggaaaagc tcaactggat aactttatgg atgtcaattc taattttccc
    14821 gctattgtaa caacgtctaa attattaacg acaggagtta atgctaaaac atgtcgtttg
    14881 attgttttag actctaatat ccaatccatg actgaattta aacaaattat tggtcgtggc
    14941 acacgtcttt atcctcaaaa ggggaaagaa ttttttacga ttattgattt tcgaaatgtt
    15001 accaatttgt ttgctgaccc tgattttgat ggtgatcctg tgaaggtgct ggaaacaggt
    15061 gcgaaaacag tcagtggttc tacgcccggt ttcgtagatg aggaaggtga cccagtagaa
    15121 aaatatatcg ttacagacaa gcaggttacc attcttaatt ctactgttca agtattagat
    15181 gaaaacggga aactgattac cgaaagcctg accgactaca ctcggaagaa tatcttaggt
    15241 agctacgcca ctttgaacga ttttatcaca gtttggcata cggcggataa aaagaagctt
    15301 atcttagacg aactttataa aaaaggagtt tatctagatg ctattcgaga gtcggaggga
    15361 atatcagaac aagaaatcga tgattttgat ttactcctaa aacttgccta tggtcaaaaa
    15421 gaattaacca aaacggaacg tatcaataaa ctcaaacaaa gcggatattt atataaatat
    15481 agtgaggaag cgcgtgctgt tttggaaatt ttactgaaca aatacatgga taaaggtatt
    15541 ggagaactcg aaagcattga aacattaaaa cttccagaat ttcagatata tggtggaacc
    15601 ttcaaaatca tcaatactta ttttggagat aaaaaacgat atttacaagc aattaaagaa
    15661 ttggagcaag agctatttac agtagcttaa tgaaaggaaa gtatgtcaat tacatcattt
    15721 gtaaaaagaa ttcaagatat cactcgaaac gatgctggtg ttaatggtga tgctcaacgt
    15781 attgagcaaa tgtcttggtt attattctta aaaatttatg atagccgtga aatggtttgg
    15841 gaattagaag aagacgagta tgagtcaatt atcccagagg aattaaaatg gcgaaattgg
    15901 gctcatgctc aaaatgggga acgggtattg acaggcgatg aattacttga ttttgtcaat
    15961 aacaagttat tcaaagagtt gaaagagctt gaaataactt caaatatgcc tattcgaaaa
    16021 acgattgtta aatcagcttt tgaagatgcg aacaactata tgaaaaatgg cgtcttgtta
    16081 cgccaagtca tcaatgttat tgatgaagtt gatttcaata gccctgaaga tcgtcattcg
    16141 tttaatgata tttacgaaaa aattcttaaa gatattcaaa atgctgggaa ctcaggagaa
    16201 ttttatacgc cacgtgcagc gactgatttt attgccgaag ttcttaaccc aaaacttgga
    16261 gaatcaatgg cagaccttgc ttgcggaaca ggaggcttct tgacttcgac tctgaaccgt
    16321 ttaagtagtc aacgtaaaac tagtgaagat accaaaaaat ataatacagc tgtttttggt
    16381 attgaaaaga aagcatttcc tcatctttta gcagttacaa atctgtttct tcacgaaatt
    16441 gatgacccta aaattgttca tggaaatact ttggagaaaa atgttcgtga atatacggat
    16501 gatgaaaaat ttgacattat tatgatgaat ccaccttttg gagggtcaga attagaaaca
    16561 ataaaaaata actttccagc agaattacgg agttctgaaa cagctgattt atttatggct
    16621 gtcattatgt atcgtttgaa agaaaatggt cgtgttggag ttattttacc tgatggtttt
    16681 ctatttggtg aaggtgtaaa aactcgcttg aaacaaaaac tggtagatga gttcaacttg
    16741 catacgatta ttaggttgcc tcatagtgtc tttgcaccgt atacaggaat ccatacgaac
    16801 attcttttct ttgataaaac aaagaaaaca gaagaaactt ggttttatcg tttagatatg
    16861 ccagatggtt ataaaaattt ctcgaaaact aagccgatga agtcagaaca cttcaatcct
    16921 gttcgtgact ggtgggaaaa tcgtgaagag attctggaag gtaagttcta caaatctaaa
    16981 tcatttacac ctagtgaatt ggctgagttg aattataatt tagaccagtg tggctttcca
    17041 aaagaggaag aggaaatctt agatcccttt gagttgattc agaattatca agcggaaaga
    17101 gcaactttaa atcataagat tgataatgta ttagctgata ttttgcagtt gttggaggac
    17161 aaataatgac accagaacaa cttaaagcaa gtattctcca aagagcgatg gaagggaaat
    17221 tagtgccgca aaatcccaat gacgaacctg caagtgaatt attaaagaga attaaagctg
    17281 aaaaagaaaa acttatcagt gaaggaaaaa tcaaacgaga taaaaaggaa actgagatat
    17341 ttcgtggtga tgatgggaaa cattatggga agtttgctga tggaagcact caagaaattg
    17401 atgttcctta tgatattcct gatacttggg agtgggtgag gttttctaca ttggttgaaa
    17461 ttgtcagagg tggctctcca cgaccaatca aagattatct tacttctgaa gtagatggaa
    17521 taaattggat aaaaataggt gatactgaaa agggtgaaaa gtatataaat aatgttaaag
    17581 aaaaaatcaa aaaatcaggg cttaacaaaa ctagatttgt aaaaaaaggt acatttttgt
    17641 taactaattc tatgagtttt ggtagacctt atattttgaa tgttgatggt gcaatacacg
    17701 atggatggtt ggctatttcg aactatgaaa actcattaaa taaagattac ctattctata
    17761 ttctttcatc aaatgtagtt tattctcaat ttctatctct aattagtgga gctgttgtga
    17821 aaaacttgaa tagtgataaa gttgcttcta ttcttatccc tctccctccg ctagctgaac
    17881 aacaacgcat aatagaagca atcgaatcag ctttagaaaa agtagatgaa tatgctgaaa
    17941 gttataatag actagaacag ctagataaag aatttccaga taaactaaaa aaatctattc
    18001 ttcaatatgc tatgcaagga aaattagttg aacaagaccc aaatgatgaa tcagtcgaag
    18061 ttttacttga aaaaatacga gcagaaaaac aaaaactctt tgaagaaggc aagattaaaa
    18121 agaaagattt ggacatttct attgtttccc aaggagatga taactcttat tatgggaaca
    18181 aagacgaaac aacctcttat cctatatatg aaatcccaga agcatggaga tatattaaat
    18241 ttgctagcct agttaacttc agaataggaa aaactcctcc acgcagtgaa gctacttttt
    18301 ggggaactga aataccctgg gtatctatat cagatatgcc tatatctggt tatgtaacta
    18361 atacgagaga atctatttct aaattagcat taaaatcaaa gaaaatagac atttcaccta
    18421 aaggaacttt attaatgagt tttaaattat ctattggaaa agttgccata ttggatattc
    18481 ctgccactca taatgaagcc attatatcga tattccccta tgctaacaaa gaaaatatta
    18541 tcagagatta cttaatgata tttttgccac ttatctctac tttaggtgat tcaaaagatg
    18601 ctatcaaagg gaaaacatta aatagtacca gtatctccga attattaatc cctatttcta
    18661 atcatgaaga gatgaaaaga atcatttcca aagttgattt actttttcaa aaagtttctc
    18721 aactttttga gtaataagtt cctgttcctc aaaaggagct aacggaatta atagctcgct
    18781 tagtgtagtt ttaggaatat tatataaagc ttgacctgat agtttagtta ttgctttcaa
    18841 ttgtttataa aataacggag aggacaagtt aaataataga aattttgaaa taatctctga
    18901 actttcgaat ggtgttaatt ggaaaataaa tccaccagcc acaacaccat catagtcttt
    18961 atcgattctt gcaaactttc caatatgttc taaagaggtt gctacaggtg ttattagctg
    19021 attatgtttt aaataaactt gctcagagga gatgaattgt gtatcaatgt agtaatcatt
    19081 atccaacaga gaaaattcta aaggcttaat attaccacca cgtataattc taacaccttt
    19141 attattaatg cttaaatcgc ccttcttgta agaaagacct gtattcattg aaaaaatatc
    19201 ttttattttt ataacaaccc aattcatagg tat
//
LOCUS       DAVHIZ010000036        18710 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.038, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000036 DAVHIZ010000000
VERSION     DAVHIZ010000036.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18710)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18710)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18710
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.038"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(299..1396)
                     /locus_tag="VVO18_001411"
     CDS             complement(299..1396)
                     /locus_tag="VVO18_001411"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000156376.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase"
                     /protein_id="HEU5586547.1"
                     /translation="MTITGIIAEFNPFHNGHKYLLDQAEGLKIVAMSGNFMQRGEPAI
                     VDKWTRAQMALENGADLVVELPFLVSVQAADFFGQGAVDILDRLGIDSLVFGTEEVRD
                     YQKIADLYTEKGTEMEKFVENLPDSLSYPQKTQAMWKEFAGLDFSGNTPNHVLALAYA
                     KAVAGRNIKLHPIQRQGAGYHSVNKDVDFASATALRQHQKDQDFLERFMPSVALFEQA
                     SKVIWEDYFPLLRYQILSNPDLTTIYQVNQEMAVRIKEAIKTAQSVEELVELVTTKRY
                     TKARVRRLLTYILMQARENVLPEAIHVLGFTEKGRQHLKSLKGQVSLVSRIGKEPWDA
                     MTQKADQIYQLGKPSIAEQNFGRVPIRIETN"
     gene            complement(1406..2152)
                     /locus_tag="VVO18_001412"
     CDS             complement(1406..2152)
                     /locus_tag="VVO18_001412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000605145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="HEU5586548.1"
                     /translation="MIMATYETFAAVYDAVMDDSLYDKWTNFSLRHLPKTKERKKLLE
                     LACGTGIQSVRFSQAGFDVTGLDLSADMLKIAEKRATSAKQKITFIEGNMLNLSNAGK
                     YDFVTCYSDSICYMQDEVEVGDVFKDVYNALNEEGVFIFDVHSTYQTDEVFPGYSYHE
                     NAEDFAMLWDTYEDEAPHSIVHELTFFIKEADGSFSRHDEVHEERTYEILTYDILLEQ
                     AGFKSFKLYADFEDKEPTETSTRWFFVAQK"
     gene            complement(2255..2608)
                     /gene="rsfS"
                     /locus_tag="VVO18_001413"
     CDS             complement(2255..2608)
                     /gene="rsfS"
                     /locus_tag="VVO18_001413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003018.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome silencing factor"
                     /protein_id="HEU5586549.1"
                     /translation="MNEKELLELVVKAADEKRAEDILALDVQDLTSVTDYFVITSSMN
                     SRQLDAIAANIREKVAQAGFKGSHVEGDAAGGWVLLDLGAVVVHIFSEEMRAHYNLEK
                     LWHEANSVDISEALA"
     gene            complement(2621..3121)
                     /locus_tag="VVO18_001414"
     CDS             complement(2621..3121)
                     /locus_tag="VVO18_001414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000844697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine hydrolase"
                     /protein_id="HEU5586550.1"
                     /translation="MKTAFIIIDVQNVLVETGFQTKSLLGKISYLQNQARSKNIEIIY
                     VQHIENSEAQTSEDWQLSALLNRKPAEKVFQKKYNSIFKETGLKEYLDKQGIEKLVLC
                     GMQTEYCVDTSVKVAFEYGYQLIVPEGAVTTFDGDDIPAETINEFYEDIWEERFADVL
                     DYKHIF"
     gene            complement(3122..3715)
                     /gene="yqeK"
                     /locus_tag="VVO18_001415"
     CDS             complement(3122..3715)
                     /gene="yqeK"
                     /locus_tag="VVO18_001415"
                     /EC_number="3.6.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="HEU5586551.1"
                     /translation="MSYQDYINCSREALLEKMAELLPEKRLTHCLGVERAAMELAQRF
                     GVDVEKASLAGLLHDYAKKLSDQEFLDLIDRYQLDPDLKNWGNNVWHGMVGIYKIQED
                     LDLHDSEILRAIEIHTVGAGQMTDLDKVIYVADYIEHNRAFPGVDVAREIASLSLNKA
                     VAYETARTVEYLAHQGFPIYPQTLETYNAFVHYLKEN"
     gene            complement(3715..4344)
                     /locus_tag="VVO18_001416"
     CDS             complement(3715..4344)
                     /locus_tag="VVO18_001416"
                     /EC_number="2.7.7.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate-nucleotide adenylyltransferase"
                     /protein_id="HEU5586552.1"
                     /translation="MTIELLTPFTKVELEPEIKEKKRKQVGILGGNFNPVHNAHLIVA
                     DQVRQQLGLDQVLLMPEYQPPHVDKKETIPEHHRLKMLELAIEGIDGLVIETIELERK
                     GISYTYDTMKILTEQHPDTDYYFIIGADMVDYLPKWYRIDELVDMVQFVGVQRPRYKA
                     GTSYPVIWVDVPLMDISSSMVRDFIAQGRKPNFLLPQPVLDYIEKEGLY"
     gene            complement(4396..4707)
                     /gene="yhbY"
                     /locus_tag="VVO18_001417"
     CDS             complement(4396..4707)
                     /gene="yhbY"
                     /locus_tag="VVO18_001417"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060164.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome assembly RNA-binding protein YhbY"
                     /protein_id="HEU5586553.1"
                     /translation="MSLTSKQRAFLNSQAHTLKPIIQIGKNGLNDQIKTSVRQALDAR
                     ELIKVTLLQNTDENIHEVAEILEEEIGVDTVQKIGRILILFKQSSKKENRKISKKVKE
                     I"
     gene            complement(4921..6027)
                     /gene="yqeH"
                     /locus_tag="VVO18_001418"
     CDS             complement(4921..6027)
                     /gene="yqeH"
                     /locus_tag="VVO18_001418"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000391231.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="HEU5586554.1"
                     /translation="MEEILCIGCGATIQTTDKAGLGFTPQSALEKGLETGEVYCQRCF
                     RLRHYNEITDVQLTNDDFLKLLHEVGDSDALVVNVIDIFDFNGSVIPGLPRFVSGNDV
                     LLVGNKKDILPKSVKSGKISQWLMKRAHEEGLRPVDVVLTSAQNKHAIKEVIDKIEHY
                     RKGRDVYVVGVTNVGKSTLINAIIQEITGDQNVITTSRFPGTTLDKIEIPLDDGSYIY
                     DTPGIIHRHQMAHYLTAKNLKYVSPKKEIKPKTYQLNPEQTLFLGGLGRFDFIAGEKQ
                     GFTAFFDNELKLHRSKLEGASAFYDKHLGTLLTPPNSKEKEDFPRLVQHVFTIKDKTD
                     LVISGLGWIRVTGIAKVAVWAPEGVAVVIRKAII"
     gene            complement(6030..6620)
                     /locus_tag="VVO18_001419"
     CDS             complement(6030..6620)
                     /locus_tag="VVO18_001419"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844147.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="HEU5586555.1"
                     /translation="MDCFILVTKENCEKKLRKGARMAIENYIPDFAVEAVYDLTVPSL
                     QAQGIKAVLVDLDNTLIAWNNPDGTPEMKQWLHDLRDAGIGIIVVSNNTKKRVQRAVE
                     KFGIDYVYWALKPFTFGIDRAMKEFHYDKKEVVMVGDQLMTDIRAAHRAGIRSILVKP
                     LVQHDSIKTQINRTRERRVMRKITEKYGPITYKKGI"
     gene            complement(6572..7480)
                     /locus_tag="VVO18_001420"
     CDS             complement(6572..7480)
                     /locus_tag="VVO18_001420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="magnesium transporter CorA family protein"
                     /protein_id="HEU5586556.1"
                     /translation="MVLEKQLGNGCTWIDLDLGKLNKLEDLSEIYGLDKETIEYALDR
                     NERAHMDYHRESGTVTFIYNVLDVKKDKAYYETFPMTFIVEHRRLITISNTKNAYVIG
                     QMTRYLESHDTLSIYKFLFASLEIISNAYYPVIEQMDKSRDEVNDLLRQRTTKKNLFA
                     LSDLETGMVYLTAAAKQNRILLEHIQGHALYRSFDEIEREQFDDAMIEAHQLVSMTDL
                     ISQILQQLSASYNNILNNNLNDNLTTLTIISVLLAVLAVVTGFFGMNVPLPLTDEPHA
                     WLYISLASAGLWIVLSLLLRKIAKKS"
     gene            complement(7537..8097)
                     /locus_tag="VVO18_001421"
     CDS             complement(7537..8097)
                     /locus_tag="VVO18_001421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel"
                     /protein_id="HEU5586557.1"
                     /translation="MQKFIQAYIEKLDVTTIIENILTKVISLLLLLIVFYIAKKMLHT
                     MVQRIVKPSLKMSRHDVGRQKTISRLLENVFNYTLYFFLLYCILSILGLPVSSLLAGA
                     GIAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNGPITVSGKVVSVGIRTTQ
                     LRSEEQALHFVPNRNITVVSNFSRTD"
     gene            8236..9444
                     /gene="sstT"
                     /locus_tag="VVO18_001422"
                     /pseudo
     CDS             8236..9444
                     /gene="sstT"
                     /locus_tag="VVO18_001422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713440.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine transporter SstT"
     gene            9512..10465
                     /locus_tag="VVO18_001423"
     CDS             9512..10465
                     /locus_tag="VVO18_001423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028179.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aromatic acid exporter family protein"
                     /protein_id="HEU5586558.1"
                     /translation="MSISQRTTKLILATCLAYLLAYFLNLSSAVSAGIIALLSLSDTR
                     RSTLKLARNRLFSMLLALAIGVLAFHLSGFHIWSLGLYLAFYVPLAYKMGWEIGITPS
                     TVLVSHLLVQESTSPDLLVNEFLLFAIGTGFALLVNLYMPSREEEIQHYHTLVEEKLK
                     DILQRFKYYLSRGDGRNRAQLVAELDTLLKEALRLVYLDHSDHLFHQTDYHIHYFEMR
                     QRQSRILRNMAQQINTCHLAASESLILAQLFSKIAGQLSQTNPASDLLDEIERYLEVF
                     RNRSLPKTREEFETRATLLQLLREAKTFIQVKVDFYQKYRQ"
     gene            10608..10988
                     /locus_tag="VVO18_001424"
     CDS             10608..10988
                     /locus_tag="VVO18_001424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="HEU5586559.1"
                     /translation="MTYLEKWFDFNRRQKEIESLLEETIAQQSKQSLTLKEFYLLYYL
                     DLAEEKSLRQIDLPDKLHLSPSAVSRMVARLEAKNCGLLSRMCCHQDRRSSFICLTND
                     GQKTLASLQKTVEESLEAGLDFLI"
     gene            11087..11308
                     /locus_tag="VVO18_001425"
     CDS             11087..11308
                     /locus_tag="VVO18_001425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4649 family protein"
                     /protein_id="HEU5586560.1"
                     /translation="MIEITYLDASKNERTVTFESYEDFERSQQACLIGVADYYPVQKL
                     TYKGHNLDYHGTYGDIFFYLMKQDLSQYN"
     gene            11325..11639
                     /gene="trxA"
                     /locus_tag="VVO18_001426"
     CDS             11325..11639
                     /gene="trxA"
                     /locus_tag="VVO18_001426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003004519.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="HEU5586561.1"
                     /translation="MAKAITDATFEQETKDGLVLVDFWATWCGPCRMQGPILDKLSEE
                     LSEDVLKIVKMDVDENPNTARAFGIMSIPTLLFKKDGQVVKQVAGVHTAEQIKAIIAE
                     LS"
     gene            11944..12477
                     /gene="queF"
                     /locus_tag="VVO18_001427"
     CDS             11944..12477
                     /gene="queF"
                     /locus_tag="VVO18_001427"
                     /EC_number="1.7.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000828792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent 7-cyano-7-deazaguanine reductase
                     QueF"
                     /protein_id="HEU5586562.1"
                     /translation="MKRQSALVVFSGGQDSTTCLFWAMQHYETVEAVTFAYGQHHHLE
                     IQIAREIAKEQGIRHHILDMSLLGQITAQPDFATIHISYIPDKLCVESKSLKLYLFSY
                     RNHGDFHENCINTIGKDLVNLLDPRYLEVWGKFTPRGGISIDPYYNYGKQGTKYEGLA
                     EQRLFQHDLYPEKIDNR"
     gene            12527..12910
                     /locus_tag="VVO18_001428"
     CDS             12527..12910
                     /locus_tag="VVO18_001428"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586563.1"
                     /translation="MLKAVFEVIDKTDEVSLKHCFEVADRTDEVSLKHCFEVVDETDE
                     VSLKHCFEVADRTDEVSLKHCFEVADRTDEVSLKHCFEVVDETDEVSLKHCFEVVDET
                     DEVSLKHCFEVADRTDEVSNIYTTR"
     gene            complement(13000..13668)
                     /locus_tag="VVO18_001429"
     CDS             complement(13000..13668)
                     /locus_tag="VVO18_001429"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714831.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin"
                     /protein_id="HEU5586564.1"
                     /translation="MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGYLGIAFAFGLAI
                     VVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLAN
                     SGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLS
                     LMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFL
                     GTEE"
     gene            complement(13779..14333)
                     /locus_tag="VVO18_001430"
                     /pseudo
     CDS             complement(13779..14333)
                     /locus_tag="VVO18_001430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399297.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2785 domain-containing protein"
     gene            complement(14579..16375)
                     /gene="pepF"
                     /locus_tag="VVO18_001431"
     CDS             complement(14579..16375)
                     /gene="pepF"
                     /locus_tag="VVO18_001431"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000435555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oligoendopeptidase F"
                     /protein_id="HEU5586565.1"
                     /translation="MEQKHRSEFPEKELWDLTALYQDREDFLRAIEKAREDINQFSRD
                     YKGNLHTFEDFEKVFAELEQIYIQMSHIGNYGFMPQTTDYSNDEFANIAQAGMEFETD
                     ASVALTFFDDALVAADEEVLDRLGKLPHLTAAIRQAKIKKAHYLGADVEKALTNLGEV
                     FYSPQDIYTKMRAGDFEMADFEAHGKTYKNSFVTYENFYQNHEDAEVREKSFRSFSEG
                     LRKHQNTAAAAYLAQVKSEKLLADMKGYDSVFDYLLAEQEVDRVMFDRQIDLIMKDFA
                     PVAQRYLKHVAKVNGLEKMTFADWKLDLDSALNPEVTIDDAYDLVMKSVEPLGQEYCQ
                     EVARYQEERWVDFAANSGKDSGGYAADPYRVHPYVLMSWTGRLSDVYTLIHEIGHSGQ
                     FIFSDNHQSYFNAHMSTYYVEAPSTFNELLLSDYLENQSNDPRQKRFALAHRLTDTYF
                     HNFITHLLEAAFQRKVYTLIEEGETFGASKLNSIMKEVLTDFWGDAIEIDDDAALTWM
                     RQAHYYMGLYSYTYSAGLVISTAGYLHLKNSETGAEDWLNLLKSGGSKTPLESAMIIG
                     ADISTDKPLRDTIQFLSDTVDQIIAYSAELGE"
     gene            complement(16386..17129)
                     /locus_tag="VVO18_001432"
     CDS             complement(16386..17129)
                     /locus_tag="VVO18_001432"
                     /EC_number="2.1.1.193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001188214.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (uracil(1498)-N(3))-methyltransferase"
                     /protein_id="HEU5586566.1"
                     /translation="MQQYFVKGSAVSPVTIEDRETSKHMFQVMRLKEDDEVTLVFDDG
                     IKRLARVLDVEARQFELVEELDDNVELPVQVTISSGFPKGDKLEFITQKVTELGASQI
                     WAFPADWSVAKWDGKKLGKKVEKLEKIALGAAEQSKRNIVPSIKLFEKKADFLAQLDQ
                     FDSIIVAYEESAKEGEAAALLQAVTGLETGAKLLFIFGPEGGLSPAEIESFEAKGAVL
                     AGLGPRILRAETAPLYALSALSVLVELEK"
     gene            complement(17131..18081)
                     /locus_tag="VVO18_001433"
     CDS             complement(17131..18081)
                     /locus_tag="VVO18_001433"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000451122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="HEU5586567.1"
                     /translation="METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYVGNVD
                     RFGEIFPEVEQQEEIVVTAYYPETVDVAAVEADLQARLAELTDFMDLGEVKMGTTALT
                     EEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMS
                     LFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNTG
                     MENIHVAAGDLLKGVEIEADVIVANILADILIHLIDDAYRLVKDEGYLIMSGIIKDKW
                     DMVRQSAESAGFFLETHMVQGEWNTCVFKKTKDISGVIGG"
     gene            complement(18094..>18710)
                     /locus_tag="VVO18_001434"
     CDS             complement(18094..>18710)
                     /locus_tag="VVO18_001434"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001028052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HEU5586568.1"
                     /translation="PAIDKKYNENLYQHDIVNILTLNYTNVIDKLYNESAKSFSNQLR
                     TNNYKFHIAPPIHAHGTVDICTVLGVSDETQISNSFDEEQKESLIKNLVLKNYRENMD
                     VKNSDIIKNSDIIILYGVSLGETDGYIWNQIAEQSIRSSVPVIIYHYVPHFDAGNPTR
                     VKRLYRNVEDKFIQNSGIDLELEKKLRDNLIVVIGKTIFNLMER"
BASE COUNT         5268 a         4275 c         3638 g         5529 t
ORIGIN      
        1 ttaccttctt catgtagtcc tttaaatgat ttcggaatgt tgagtaaagg actgcttcca
       61 taaccatacc tcgttttagc tcttttccac tattatacac gaaaagaaag aaattgtcag
      121 gaacttgtac aagattttct tttctatcta tttatactca atgaaaatca aagagcaaac
      181 taggaaacta gccgcaggct gtacttgagt acggcaaggc gacgttgacg cgatttgaat
      241 ttgattttcg aagagtatta ttcgtaaaaa atctcaaaaa gtccaccttt cggtagactt
      301 agtttgtttc tattctaatc ggcactcttc caaaattttg ctctgctata cttggctttc
      361 ctagttggta aatctggtct gctttttggg tcatagcatc ccaaggttct ttgccaattc
      421 ggctgactag actgacctga cctttcaaag acttgagatg ttgcctacct ttttcagtaa
      481 atccaaggac atgaatggct tctggcaaga cattttctct agcctgcatc aaaatatagg
      541 tcaataggcg tctgacacgc gccttggtgt aacgtttggt agtcactaac tcgaccaatt
      601 cttccacaga ctgggctgtt ttaatagctt ctttaatgcg cacagccatt tcttgattga
      661 cctgatagat ggtggttaag tcgggatttg acaagatttg atagcggagc aagggaaaat
      721 agtcttccca gatcacctta ctggcctgct caaatagggc aacagaaggc ataaaacgtt
      781 ctaagaaatc ttggtccttc tgatgttgac ggagggctgt cgccgaggca aagtccacat
      841 ctttattcac agaatggtaa cctgccccct gacgctgaat cggatgcagc ttgatattcc
      901 gtcctgcaac cgccttggca taggccagag caagaacatg attgggggta ttacctgaaa
      961 aatcaagacc agcaaattcc ttccacatag cttgggtttt ctggggatag gaaagggaat
     1021 caggcagatt ttccacaaat ttctccatct cagtaccttt ctctgtgtat aagtcagcga
     1081 ttttctgata atctcgaact tcctctgtcc caaaaactag actatcaatg cccaagcgat
     1141 ccaagatatc cacagctcct tgaccaaaga aatcagctgc ctgaacactg actaaaaagg
     1201 gcaattccac taccaagtct gcgccatttt ccagcgccat ctgggccctt gtccacttat
     1261 ccacaatagc aggctctcca cgctgcatga aattccctga catggcaaca attttcagtc
     1321 cctctgcctg atccagcagg tatttatggc cattatgaaa aggattgaac tctgcgataa
     1381 tacctgtgat ggtcatgatg ttctcctact tctgcgccac aaaaaaccaa cgggtgctag
     1441 tttctgttgg ctccttatcc tcaaagtctg catagagttt gaaagactta aatccagcct
     1501 gttccagcaa gatatcatag gtcaagatct cataggtcct ctcctcatgt acttcatcat
     1561 gacgactaaa ggaaccgtca gcctccttga taaagaaagt cagctcatgc acgatggagt
     1621 gaggagcttc gtcctcatat gtatcccaaa gcatggcaaa atcttccgca ttttcatggt
     1681 aggaatagcc agggaatact tcatctgtct ggtaggtcga gtgcacgtca aagatgaaaa
     1741 ctccctcttc attcagcgca ttgtacacgt ccttaaagac gtcccctact tccacctcat
     1801 cctgcatata gcagatagag tccgaataac acgtgacaaa atcgtatttc cctgcattgg
     1861 acaaattcag catattacct tctataaaag taatcttttg cttggctgaa gttgctctct
     1921 tctccgcaat cttcaacata tccgcactca agtcaagtcc agtcacatca aaaccagcct
     1981 gagagaagcg cactgattga attcctgtcc cacaagccaa ttccaagagt ttctttctct
     2041 ccttggtctt aggcaaatga cgcagagaaa aattcgtcca tttgtcgtat aaactatcgt
     2101 ccatgaccgc atcatagacc gccgcaaagg tttcataagt cgccataatc atgatactaa
     2161 gagctccatg gtaaacacca ctagcccttt acctttctat caatttttct aaaataagca
     2221 aagaaaccca gttgactaca actgagttca tcttctaagc aagagcttct gaaatatcta
     2281 ctgaattcgc ctcatgccat agcttctcta gattataatg ggcacgcatt tcttctgaaa
     2341 agatatgcac gacaacagca ccgaggtcca gtaagaccca gcctccagct gcatcgcctt
     2401 cgacatggct acctttaaag cctgcttgag ctactttttc acggatatta gctgcgatag
     2461 cgtccaactg acggctattc attgagctag tgatgacaaa gtagtccgtc acactagtca
     2521 aatcttgtac atcaagtgcg aggatatcct ccgcacgttt ctcatcagcc gctttcacga
     2581 ctagttctag taattctttt tcgttcattt aatcctcttt ttagaaaata tgtttgtaat
     2641 ctaggacatc tgcaaagcgc tcctcccaaa tgtcctcata aaattcatta atcgtttctg
     2701 ctggaatgtc atccccatca aaggttgtga cagcaccttc tggaacaata agctgatagc
     2761 catattcaaa ggcaaccttg acagaggtat ccacacaata ttctgtctgc ataccacata
     2821 aaactaattt ttcaatcccc tgcttatcca agtattcttt taagccagtt tctttgaaaa
     2881 tactgttata tttcttctga aagacctttt cagcaggttt tcgatttaaa agcgcagata
     2941 actgccaatc ttctgatgtt tgagcttcag agttctcaat atgttgaaca tagataattt
     3001 caatattctt gcttctagcc tggttttgta aataagaaat ttttcccaat agactttttg
     3061 tctggaaccc agtttctact aaaacattct gaacatcaat gattataaaa gccgtcttca
     3121 tttagttctc tttcaaatag tgcacaaagg cgttataggt ttcaagggtt tggggataga
     3181 tggggaatcc ctgatgagct agatactcca cggtacgagc tgtttcgtag gccaccgcct
     3241 tattgagcga tagacttgca atctcacgcg ccacatccac tccaggaaat gcccgattgt
     3301 gctcgatata gtctgcgacg tagatgacct tatctaggtc tgtcatttga ccagctccga
     3361 ctgtatgaat ttcaatggct cgcagaattt cagaatcatg caaatccaaa tcttcctgaa
     3421 ttttgtaaat tccgaccata ccatgccaga cattattgcc ccagtttttg aggtcagggt
     3481 ctagctggta acggtcaatc aagtctagaa attcctgatc tgacaacttt ttagcatagt
     3541 catgaagaag acctgctaga cttgctttct caacatctac accaaagcgc tgagctaatt
     3601 ccatagcagc acgctccaca cctagacaat gggttagacg tttctcaggt agaagctctg
     3661 ccattttttc caacaaggcc tcacgggagc agttgatata gtcttgatag gacatcagta
     3721 gagcccctcc ttctcgatgt agtctagcac tggctgaggt aggagaaagt tgggtttccg
     3781 accttgggca atgaagtccc gcaccatgct ggacgagata tccatgagcg gtacgtccac
     3841 ccagataact ggataggaag tccctgcctt gtagcgtgga cgctgaaccc ccacaaactg
     3901 aaccatgtca accagttcat caattcggta ccacttaggc agatagtcaa ccatgtcggc
     3961 gccgatgata aagtaataat ccgtatctgg atgttgctct gtcaagattt tcatggtgtc
     4021 gtaggtgtag gaaataccct tgcgctccaa ctcaatggtt tcaatgacta ggccgtcaat
     4081 cccctcaatt gccaactcaa gcatcttgag acgatggtgt tcagggatgg tttccttttt
     4141 atcaacgtga ggaggttggt attcaggcat gagaagaact tgatccagtc ccaactgttg
     4201 ccgtacttga tccgcaacaa tgagatgggc attgtgaaca gggttaaaat tcccccctaa
     4261 aatcccaact tgtttgcgtt ttttctcctt gatttctggc tccaactcta ccttggtaaa
     4321 gggagtcaat agttcgattg tcataggcta gtccccttta tttctctata aaaacagtta
     4381 tttggagttt cggtcttaga tttctttgac tttcttagaa atcttgcgat tttctttctt
     4441 gctagattgt ttaaacaaaa tcaagatgcg tcctattttt tggactgtat ccacaccgat
     4501 ttcttcttcc aaaatttcag ctacttcgtg gatgttttca tctgtgtttt gtaagagagt
     4561 aaccttgatt aattcacgcg catcaagagc ttgacggacg ctggttttga tttggtcgtt
     4621 gagtccattt ttcccgattt ggatgatagg tttgagggtg tgtgcctggc tgttgaggaa
     4681 ggcacgttgt tttgatgtta atgacataat tttcttcctt gttttttgat agttatttta
     4741 ggtggtgagg gacggtcgga actaattttc caaagatttc atctttgaaa aatggatttc
     4801 ctgacctcac aattgagcct tggtctcaat tgtgcccctt gccaatctac agattggcaa
     4861 tcacaccacg gcaataacta tcgctatatg agctcacttt gttcgctcag cgattttgtt
     4921 ttaaataatt gcttttcgta tgacgacggc gacgccttct ggtgcccaga cggcgacttt
     4981 tgctatgcct gttacacgaa tccagcctag gcctgagatg actaggtctg tcttatcttt
     5041 aatggtaaag acatgctgga ctagccttgg gaaatcttct ttttccttgc tatttggtgg
     5101 tgtcagaaga gttcccaggt gcttatcgta gaaagcacta gctccttcaa gcttgctacg
     5161 atggagtttg agttcattat caaagaaagc agtaaatcct tgcttttctc ctgctataaa
     5221 gtcaaagcgt cccaaaccac ctaaaaatag ggtttgctca ggattaagct gataggtctt
     5281 aggcttgatt tcctttttag gactgacata cttgaggttt ttggccgtca agtagtgagc
     5341 catctggtgg cggtggataa ttcccggcgt atcgtaaata taagatccgt cgtcaagcgg
     5401 aatctctatt ttgtccaagg ttgtccctgg gaagcgtgaa gtagtgatga cattctgatc
     5461 acccgtgatt tcttggataa tagcattgat tagagttgat tttccaacgt tggtcacacc
     5521 gaccacatag acatcgcggc ccttacggta gtgttcaatc ttgtcaatga cttccttaat
     5581 ggcatgttta ttttgtgctg aagttaggac cacatcgact ggacgaagac cttcttcatg
     5641 ggcacgtttc atgagccact ggctaatctt accagactta actgacttag gaaggatatc
     5701 ttttttattt cctaccaaga ggacatcatt gcccgagacg aaacgtggta aacctgggat
     5761 gacagatcca ttaaaatcaa agatatcaat gacattgacc actaaagcat cactgtctcc
     5821 cacctcgtgc aagagcttga ggaaatcatc gttcgtcaac tggacatctg tgatttcatt
     5881 gtagtggcgg agacggaaac agcgttggca atagacttcg ccagtctcca aacctttttc
     5941 aagtgccgac tggggggtaa aaccaagacc agctttatct gtcgtctgaa tggttgctcc
     6001 acaaccaata cagagaattt cttccatagt taaattcctt ttttatatgt aatcggtccg
     6061 tacttttcag tgatttttct cataacacga cgctcacgag ttcggttaat ctgcgttttg
     6121 attgagtcat gttggaccaa gggtttgact aaaattgacc gaatccctgc acggtgggct
     6181 gctcgtatat ctgtcatgag ctggtcacca accatgacca cttccttttt gtcatagtgg
     6241 aattccttca tagcacggtc aataccaaat gtgaagggct tcaaggccca gtaaacgtaa
     6301 tcaatcccaa atttctcaac tgctcgttga acgcgttttt tggtgttatt tgacactacg
     6361 ataatgccaa tacccgcgtc ccgaaggtca tgtagccatt gcttcatctc tggcgttcca
     6421 tcagggttgt tccaagcaat gagggtatta tccaaatcga ccaaaacagc cttgatgccc
     6481 tgcgcctgca ggcttgggac tgtcagatca tagactgctt ccacagcaaa atctggtata
     6541 taattttcaa tcgccattct ggctcctttt cttaactttt tttcgcaatt ttccttagta
     6601 acaaggataa aacaatccac aaacctgcac tagccaaact gatatagagc caagcatggg
     6661 gctcatctgt taaaggtaag ggaacattca ttccgaaaaa gcctgtcacg actgccaaaa
     6721 cagctagcaa gactgaaatg atagtcaagg ttgtcaaatt gtcattcaga ttattgttta
     6781 gaatattgtt gtaagaggct gaaagctgct gtaaaatctg agagattagg tctgtcatgg
     6841 ataccagctg atgagcctca atcatggcat catcaaactg ttctctctca atctcatcaa
     6901 aactacgata caaggcatga ccttgaatat gctctaacaa aatccgattt tgtttggcag
     6961 ctgccgtcag ataaaccata ccagtctcca aatcagacag ggcaaagagg tttttcttgg
     7021 tagttcgctg gcgcaaaagg tcattgacct catccctact cttgtccatc tgctcaatga
     7081 caggatagta ggcattgctg atgatttcca gactggcaaa gagaaactta taaatcgaaa
     7141 gcgtgtcatg gctctccaga taacgagtca tctgtccaat gacataggcg ttcttggtat
     7201 tactaatggt aatcaggcga cgatgctcga cgataaaggt catgggaaaa gtctcatagt
     7261 aggccttgtc cttttttacg tctaggacat tatagataaa ggtaaccgtc ccactttcac
     7321 ggtggtagtc catgtgggcg cgctcgtttc tatccagtgc gtattcaatg gtttccttgt
     7381 ccaaaccgta aatttcagaa aggtcttcta gtttattcaa ctttcctagg tctaggtcta
     7441 tccaggtaca accattgccc aactgctttt ctaaaaccat cttttctcct tattaaactc
     7501 cctctattgt accacaaatt acttaaaata acaggtctag tctgtgcgtg agaaattgct
     7561 aacaactgtg atatttcggt tagggacaaa gtgaagggct tgctcctcgc tacgaagctg
     7621 tgtcgtacga attcccacac tgacaacctt acccgataca gtaatcggtc catttgtcag
     7681 aacgacctca tctcccacat ccagttgacg ttcaaagagg ataaaaaagc cattgatgac
     7741 atcagacaga aagccttggg ctcccatacc aatcgctacc ccagcaatac cagctccagc
     7801 cagcaaacta gaaactggca aacctaaaat cgacaaaatg cagtagagta aaaagaaata
     7861 tagcgtataa ttaaacacat tttctagtaa acgtgagatg gttttttggc gtccgacatc
     7921 atgacgagac atttttagag aaggtttgac aattctctgc accatggtat gaagcatttt
     7981 tttagcaata taaaatacaa tcaaaagcag taaaagagaa atgaccttgg ttagaatatt
     8041 ctcgataatg gttgtcacat ctagcttttc aatataagcc tgaataaatt tttgcatata
     8101 aaactccttt atttcattat accatatttt catcagtctc attctccata aatattcaaa
     8161 aaatagacag aaaattcttg attttgtcta tcatttatac tataatcata atcactacac
     8221 aaaaagaaga ttattatgaa aagaatcatt catgcttgga ataaggcaag ccttgtcaag
     8281 cgtatcttga ttggtatgct ttatggggaa tcctaggact gacccttcct aatctctcag
     8341 ggattgggct actcggggat ttattcgttg gaggtctaaa agctgttgct cctatcctag
     8401 tctttgccct cgttgccaat gccctttccc aacatcaaaa gggacaagat agcaatatga
     8461 aaactgttgt tttcttgtat atcctatgat agggactttc gccgctgctc ttgtagctgt
     8521 actagcaagt ttcatcgtcc ctattgaaat taccctaaat agtgccaata ctgaaattgc
     8581 accaccagat gggattgggc aggtcctcag caacctcttg ctcaaactgg ttgacagccc
     8641 agtcaacgcc ctgcttactg ctaactatat tggaatctta tcttgggcag tcatttttgg
     8701 aatcgctatg agagaagcca gtaaaaatag taaagaattg ctaaaaacta tcgctgacgt
     8761 gacttctaaa attgtcgaat ggatcatcaa tctggctcca tttggaatcc ttggtcttgt
     8821 ttttaaaacc atttctgaca agggagtcgg aagccttgcc aactacggta ttttattggt
     8881 tctattagta acgactatgc tttttgttgc ccttgtggtc accctttgat tgccttcttc
     8941 tttatgagac gtaatcctta ccctctagtt tggaactgcc tccgtgtcag cggtgtgaca
     9001 gcctttttca ctcgtagttc tgcggctaac attcctgtca acatgaaact ctgccatgac
     9061 cttggactca acccagatac ctattctgtt tctatcccac tcggttctac tatcaatatg
     9121 gctggagtag cgattaccat taacgttttg acccttgctg cagttaacac tcttggaatt
     9181 cctgttgact ttgccacagc ctttgtcctc agtgtggtag cagctatctc agcctgtggt
     9241 gcttcaggta ttgccggagg ttccctcctt cttatcccag ttgcttgtag ccttttcggt
     9301 atttctaacg atattgccat acaagttgtt ggggttggtt ttgtgattgg tgtcatccaa
     9361 gactcatgtg aaacagccct taactcttct acagatgtcc tctttaccgc cgttgccgaa
     9421 tacgcagcaa cccgtaaaaa ataactcatc aaggcaagcc tgctcatgtc ttgtctttta
     9481 cgcttttatt ctaacttatt aggaaattct tatgtctatt agccaacgta cgaccaagct
     9541 catcttagct acctgtcttg cctacctgct tgcttatttt ctcaatcttt catcagcagt
     9601 ttcggctgga attatcgctc tcttgagcct atctgatacg cgtagaagta ctttaaaact
     9661 ggctcgcaat cgtctttttt ctatgcttct agctctggct atcggtgttc tagcttttca
     9721 cttgagcgga tttcatatct ggagtctcgg cctctatctg gccttctacg ttcctttagc
     9781 ctacaagatg ggctgggaaa ttggcatcac accaagcact gttttggtta gccatctctt
     9841 ggttcaagag tcaacctctc cagaccttct agtcaatgaa ttccttctct ttgctattgg
     9901 tacaggattt gccttgcttg ttaatctcta tatgccttca cgagaagagg aaatccagca
     9961 ctaccacacg ctggtggaag aaaagttaaa agatatcctc cagcgcttca aatactattt
    10021 atccagagga gacggacgca accgagcaca gctggtagca gaattagaca cgcttttgaa
    10081 agaagccctc agactggtct atttggacca ctctgaccac ctctttcacc agaccgacta
    10141 ccatatccac tactttgaga tgagacagcg acaaagtcgt atcctgagaa acatggccca
    10201 acagattaac acttgtcacc ttgccgccag tgaaagcctg atcttagcgc aactcttttc
    10261 aaaaattgca ggtcaactga gccagaccaa tcctgcttct gatttgctag atgaaattga
    10321 acgttatctg gaagtcttcc ggaaccgcag tctgcccaag acaagagaag aatttgaaac
    10381 ccgcgccacc cttcttcaac tcctacgtga agccaaaacc ttcatccaag taaaagttga
    10441 tttttaccaa aaatatagac agtaaaaaag aaaaccacta aaaaacagag cttgccagca
    10501 ttcttgaaaa gtagtataat tattgcatgc gcaatcatct tatgacgcag agactgcccg
    10561 ttaatggact ttcttctatt tatgactcta aaaagaaagg agatactatg acctatttgg
    10621 aaaaatggtt tgacttcaat cggcgtcaga aagaaattga aagtctcttg gaagagacca
    10681 ttgcccaaca gagcaagcaa agtctgacct tgaaagagtt ctacctgctc tactatctgg
    10741 acttagctga agaaaaatct ctacgccaga ttgacctgcc agataagctt catctgagcc
    10801 cgagcgcagt ttctaggatg gtggctcgct tggaagctaa aaattgcggt ctactcagtc
    10861 gcatgtgttg ccatcaagat agacgctcta gttttatctg cctgacaaat gatgggcaaa
    10921 agacactggc ctcgctacaa aagactgtcg aagaaagctt ggaagcaggt ttggatttct
    10981 tgatttaaga tgattttaaa aaaagttgcg tgcgcaatca tttttcttga cattctcttt
    11041 tataaggagt aaaataaagt tagcattaaa caaaggagtt ttaaatatga ttgaaattac
    11101 ctatttagat gccagcaaga acgaaagaac tgtgactttc gagtcttatg aagactttga
    11161 acgttcgcaa caagcttgcc ttatcggcgt cgcagactac taccctgtcc aaaaattaac
    11221 ttacaagggt cataatttgg actaccatgg gacttatgga gatatcttct tctatctcat
    11281 gaaacaagat ttaagccaat ataactaaaa aaaggagaaa tacaatggca aaagcaatta
    11341 cagatgcaac attcgaacaa gaaacaaaag acggtttggt cttagtagac ttctgggcaa
    11401 cttggtgtgg tccatgtcgt atgcaaggtc caatcttgga caaattgtct gaagaacttt
    11461 cagaagatgt cttgaaaatc gttaaaatgg acgttgatga aaatccaaac acagctcgtg
    11521 cttttggaat catgtctatt ccaactcttc tcttcaaaaa agacggccaa gttgtcaaac
    11581 aagttgcagg tgttcacaca gcagaacaaa tcaaggccat cattgctgaa ttgagctaat
    11641 caaacgagag accaagtact ttctttggtc tcttttttct tgccctttgc catttttcaa
    11701 aaaatatgct agactatagt agattgaaac tagaatagta cacctctact tctaaaacat
    11761 tgttagaaat cgatttgact gtcctgatcg atttgtcctg ttcttatttc attttactat
    11821 ataagtagaa tattacgatg tttggggtat gccatcgcta aaaaaactcg atttggtatt
    11881 ttttagttcc ctaatgggag ctttttgcgt gctctgaaca tttcccattt tggaaggagt
    11941 actgtgaaac gtcaatcagc cttggtcgtc tttagtggtg gtcaagattc aacaacctgc
    12001 cttttctggg ccatgcaaca ctatgaaaca gtcgaagctg tcacctttgc ctacggccaa
    12061 catcatcacc tcgaaattca aattgctaga gaaatcgcca aggaacaggg cattcgtcac
    12121 catatcctcg atatgtctct gctgggacaa atcactgctc aaccagactt tgcgacgatt
    12181 catatttcct acattcctga caagctctgt gtcgagtcaa aatccctcaa actatatcta
    12241 tttagctacc gaaaccacgg agatttccac gaaaactgta tcaacaccat cgggaaagac
    12301 ttggtcaact tgctagaccc tcgctattta gaagtctggg gaaaattcac tccgcgcggt
    12361 ggcatttcaa tcgaccccta ctataactac ggtaagcaag gaactaagta tgagggcttg
    12421 gcagaacaac gcctcttcca acacgacctt tatccagaga aaattgacaa ccgctaaact
    12481 catactcaat gaaaatcaaa gagcaaacta ggaagttagc cgcaggttgc tcaaagcagt
    12541 gtttgaggtt atagataaga ctgacgaagt cagcttaaaa cactgttttg aggttgcaga
    12601 tagaactgat gaagtcagct taaaacactg ttttgaggtt gtagatgaaa ctgacgaagt
    12661 cagcttaaaa cactgttttg aggttgcaga tagaactgac gaagtcagct taaaacactg
    12721 ttttgaggtt gcagatagaa ctgacgaagt cagcttaaaa cactgttttg aggttgtaga
    12781 tgaaactgac gaagtcagct taaaacactg ttttgaggtt gtagatgaaa ctgacgaagt
    12841 cagcttaaaa cactgttttg aggttgcaga tagaactgac gaagtcagta acatctatac
    12901 gacaaggtga agctgacgtg gtttgaagag attttcgaag agtatcatac gaaaaagccc
    12961 tgttcctcaa gatgaggagc aaggcttttt gagtttcaat tattcttctg ttccaaggaa
    13021 attttttgca acaagggctg caagaactcc accagcgatt ggtgcaagga tgaaaatcca
    13081 aacttgttga agggctgcgc cgcctaccaa gacagctggt gccaagctac gagctgggtt
    13141 tactgaaagt ccagtaatct tcaatccgac aagaatcatc gccatcaatg acaaaccgat
    13201 taccaaacca gcaatcgcgc cattgccctt gctttctgaa gtcacagtca tgataaccaa
    13261 tacaaacaag aaagttgcga tgacttcaaa caagaaacca ccaaagacag tgacaccgtt
    13321 tgccaaggca ttttcaccaa gactagcagt tgacatacct gagttagcca agaggaagaa
    13381 gacagcgcca gaagcgatga aagctccaac aacctgacca aggatgtagt ttacaagttc
    13441 tgaagatgac aaacgtttgt ttacaaacat agcaatcgaa acagccgggt tcaagtgagc
    13501 acctgaaaca gttccgattg agtaggctgc caccacgatt gccaaaccaa aggcaaaggc
    13561 gattccaagg taaccaaggc catcaagacc atttccaaaa acaacagctc ctgtcccgac
    13621 gaacacaagc atgaacgtac cgattaactc agcaacaaat tttttcattt tctttctcct
    13681 tttttcaaaa actagatact agtctatcaa aagtaggaaa gggtttcaag aaaattgatt
    13741 ggaaattttt tgaaaatcat agaactatta gctaatctct agtattgaaa atactggata
    13801 gcttctttca actcatcttg taaactattt ctctggtcaa gttggacata gacttccacc
    13861 agacaggatc tgaagttgga aaatttgtaa aaatcctccc tttcttctat cggaaaatca
    13921 acagttttta tccaagaagc tacttgttct tgctccaact tcccttataa aataggttca
    13981 tagatcactc ttgctaaacg ccaatcctca tcatctgtaa agcgaatcga cattctttta
    14041 aatagttggc caagtatatc aaatacttca tgaactctgt ttttaggaaa gtctggatga
    14101 caaaccacct ctgtcagtaa atcggctcca tgtgcaaaag cgtgaaccca accatactga
    14161 cttgagaaac ctgttgtatc cttttctttt gaaagatagt gcaagccttg atttgaaagg
    14221 tcatcacgaa tttctggaga aggatttccc aaatgatcaa acaaccactg gatttcttcc
    14281 tggttataat ttggtttttc ttctgctatt tttcttagta aatcttgata catggtcaat
    14341 acctctacat ttctagcaac tgttcaaaaa ggcagtctta aatgactcaa tattgaattc
    14401 tcaattaaat acaatctgat ataaaatgac gtaaataact atcaatacca gttctacagt
    14461 aagttcaaat ttaacatcac gaccttcaac gacatttttg aaaatagcta caactaagac
    14521 aaatagaatg acgcttaaca agcccataaa catcattcta aaaaattttt ctatcccctt
    14581 actcccccaa ctcagcactg taggcgataa tctggtcaac tgtgtcagac aagaattgga
    14641 tggtatcacg gagtggtttg tctgttgaaa tatccgcacc gataatcatg gctgactcaa
    14701 gtggtgtctt gctaccacct gatttgagga gattgagcca gtcttcagct ccagtttctg
    14761 agtttttaag atgaaggtaa ccagcagtcg agataactag tcctgctgag taagtgtaac
    14821 tatacaagcc catatagtag tgagcttggc gcatccaagt caaagctgca tcgtcgtcga
    14881 tttcaatggc atcgccccaa aaatctgtca aaacttcctt cataatgctg ttgagcttgc
    14941 ttgctccaaa ggtctcccct tcttcaatca atgtatacac cttacgctgg aaggcggctt
    15001 ccaagaggtg ggtgatgaaa ttatggaagt aggtgtctgt caagcgatga gccagagcga
    15061 agcgtttttg acgtgggtca ttagactggt tctctaagta atcactgagt agcaattcat
    15121 tgaaggtcga cggtgcttca acataatagg tcgacatgtg ggcgttgaaa tagctttgat
    15181 gattgtctga aaagatgaat tgaccagaat gcccgatttc atgaatcaag gtatagacat
    15241 cgctcaaacg gcctgtccag ctcatgagta cataagggtg tacgcgatat gggtccgccg
    15301 cataaccacc ggaatccttg ccactgttag cagcaaagtc cacccagcgc tcttcttggt
    15361 aacgagcaac ttcctgacaa tattcttgcc ccaaaggttc taccgacttc atgaccaaat
    15421 cataggcatc gtcaatagtc acttcaggat tcagggcgct gtccaagtcc aatttccagt
    15481 ctgcaaaggt catcttttca agaccattta ccttggcaac atgcttgagg tatctctgag
    15541 cgactggtgc aaagtccttc atgatgaggt caatctggcg gtcaaacatg acacggtcca
    15601 cttcttgttc agctagaaga tagtcaaaga cagagtcgta tcccttcata tcagccaaga
    15661 gtttttcaga cttgacctga gccagatagg ctgctgcagc cgtattttgg tgcttacgaa
    15721 gtccctctga gaaggaacgg aaggatttct cacgaacctc agcatcctca tggttttggt
    15781 agaaattctc ataggtgaca aagctgtttt tataggtctt gccatgggct tcaaagtcag
    15841 ccatttcaaa atccccagct cgcatcttag tataaatgtc ctgcggactg tagaaaactt
    15901 caccgagatt ggtcaaggcc ttctccacat cagcccctag atagtgggct tttttgattt
    15961 tggcctgacg aatggcagct gttaaatgtg gcaatttacc caaacggtcc aagacttcct
    16021 catctgctgc caccaaggca tcgtcaaaga aggtcaaggc tacgctggca tctgtttcaa
    16081 attccatccc agcttgggca atattggcaa attcgtcatt gctatagtcc gtcgtctgag
    16141 gcataaaacc atagttgcca atatggctca tctgaatgta gatctgttcc aattccgcaa
    16201 agaccttctc gaaatcctca aaagtgtgaa gattgccctt gtaatcacgg ctaaactggt
    16261 tgatgtcttc gcgagctttc tcgattgcac gcaagaaatc ctcacggtct tggtataggg
    16321 ctgttaagtc ccagagttcc ttctctggaa attctgaacg gtgtttttgt tccattttct
    16381 tcctcttatt tctctaattc tactaaaaca ctaagggctg ataaagcgta aagcggtgct
    16441 gtttctgctc gcaaaatacg aggacctagg cctgccaaaa cggctccttt agcttcaaaa
    16501 ctttcgattt ctgcaggtga gagaccgcct tctggaccaa agataaagag cagtttggct
    16561 cctgtttcaa gaccagtgac tgcttgcaga agcgcagcgg cttctccttc tttagctgat
    16621 tcttcatagg ctactatgat agagtcaaac tggtccagct gagctagaaa atctgctttt
    16681 ttctcgaaaa gtttaatact tggtacaata ttacgcttgc tttgctcggc tgctccaagg
    16741 gcaatttttt ctagtttttc aaccttttta cccaatttct tgccatccca cttagcaacg
    16801 gaccaatcgg cagggaaggc ccaaatctgg ctggcaccta gttccgtcac cttttgagtg
    16861 ataaactcca acttatctcc cttgggaaaa ccagatgaaa tggtcacttg aacgggcagt
    16921 tccacattgt catctagttc ttctaccaat tcaaactgac gagcttccac atccagcaca
    16981 cgcgccaagc gcttaattcc atcatcaaag accaaagtaa cctcatcatc ttctttcaag
    17041 cgcataacct gaaacatatg cttgctggtt tccctgtcct cgatggtgac aggagagact
    17101 gcactcccct tgacaaaata ctgttgcatc ctagcctcca atcacaccag agatatcctt
    17161 ggttttctta aagacacagg tattccattc cccttgaacc atgtgagttt cgaggaaaaa
    17221 tccagctgac tcagccgact ggcgcaccat gtcccacttg tccttgataa tgccactcat
    17281 gatgaggtag ccttcatcct tgaccaaacg ataggcatcg tctattagat gaatgaggat
    17341 atccgccaag atattagcca caatcacatc tgcctcaatt tccacaccct taagcaaatc
    17401 tcctgctgct acatggatat tttccatacc agtgttgagc tcaatatttt cctgagcgac
    17461 acgaaccgcc acatcatcca agtcataggc gaaaatctcc ttggcaccta ggagtgagct
    17521 tgcaatagaa agaacccctg aaccagtccc tacatctagc actgtttcgc caccacgaag
    17581 aacctgttcc aaggcaaaga ggctcatctt ggttgttggg tgggtccctg tcccaaaggc
    17641 cataccagga tccagcttga taatcttttc tcctgctgtt gcctcatagt ccgtccatga
    17701 cggtacgatg gtcaggtcat gggtgatgcg tgccggttca taatacttct tccagttgtc
    17761 agcccagtct tcctcagtca aggcagtcgt gcccatcttg acttctccta ggtccataaa
    17821 gtcggtcaat tctgccagac gagcctgcaa atccgcttca actgctgcta catcaaccgt
    17881 ttcagggtag taggcggtca ctacgatttc ttcctgttgc tccacctctg ggaaaatttc
    17941 accgaatcgg tccacatttc ccacatagtc catgctgtct tcaattgcta ccccttgggc
    18001 acctaactca atcaagagat tggaaaccaa ctcctctccc tcacgcttca ctgtaacttt
    18061 taactcttgc catgtttcca ttatgtattt tgcttacctt tccatcagat taaaaatagt
    18121 ctttccaata acaacaataa ggttatctct taatttcttc tctaactcta aatcaattcc
    18181 actattttgt atgaatttgt cttctacatt tctatataag cgttttactc tagtggggtt
    18241 tcctgcatca aaatgaggta cataatggta aattatgaca ggaacagaac ttctgattga
    18301 ttgttcagca atctgattcc agatataccc atcagtctct cccaaagaaa ccccataaag
    18361 aattatgatg tcagaatttt ttataatatc gctattttta acatccatat tttctctata
    18421 gttcttcaaa actaaatttt ttattaagga ttctttttgt tcttcatcaa aactatttga
    18481 aatctgtgtc tcgtcactaa ctcctaaaac tgtgcaaata tctaccgttc catgtgcatg
    18541 aattggaggc gcaatgtgaa atttataatt attagttcgt aattgattgc taaatgattt
    18601 tgctgactca ttatataatt tatcgattac atttgtgtaa ttaagagtta atatattcac
    18661 gatatcgtgt tgatatagat tttcattata ttttttatcg atagcaggtt
//
LOCUS       DAVHIZ010000037        18695 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.039, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000037 DAVHIZ010000000
VERSION     DAVHIZ010000037.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18695)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18695)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18695
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.039"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(276..1082)
                     /gene="yidA"
                     /locus_tag="VVO18_001435"
     CDS             complement(276..1082)
                     /gene="yidA"
                     /locus_tag="VVO18_001435"
                     /EC_number="3.1.3.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000023490.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-phosphatase"
                     /protein_id="HEU5586569.1"
                     /translation="MSIKLIAVDIDGTLVNSQKEITPEVFSAIQDAKEAGVKVVIATG
                     RPIAGVAKLLDDLQLRDQGDYVVTFNGALVQETATGHEIISESLTYEDYLDMEFLSRK
                     LGVHMHAITKDGIYTANRNIGTYTVHESTLVSMPIFYRTPEEMAGKEIVKCMFIDEPE
                     ILDAAIEKIPAEFYEHYSINKSAPFYLELLKKNVDKGSAITHLAEKLGLTKDETMAIG
                     DEENDRAMLEVVGNPVVMENGNPEIKKIAKYITKSNDESGVAHAIRTWVL"
     gene            complement(1095..2399)
                     /locus_tag="VVO18_001436"
     CDS             complement(1095..2399)
                     /locus_tag="VVO18_001436"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001003495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HD domain-containing protein"
                     /protein_id="HEU5586570.1"
                     /translation="MNEKVFRDPVHNYIHVNNQIIYDLINTKEFQRLRRIKQLGTSSY
                     TFHGGEHSRFSHCLGVYEIARRITEIFEEKYPEEWNPAESLLTMIAALLHDLGHGAYS
                     HTFEHLFDTDHEAITQEIIQSPETEIHQVLLQVAPDFPEKVASVIDHTYPNKQVVQLI
                     SSQIDADRMDYLLRDSYFTGASYGEFDLTRILRVIRPIENGIAFQRNGMHAIEDYVLS
                     RYQMYMQVYFHPATRAMEVLLQNLLKRAKELYPKDKDFFARTSPHLLPFFEKNVTLSD
                     YLALDDGVMNTYFQLWMTSPDKILADLSQRFVNRKVFKSITFSQEDQDQLASMRKLVE
                     DIGFDPDYYTAIHKNFDLPYDIYRPESENPRTQIEILQKNGELAELSSLSPIVQSLAG
                     SRHGDNRFYFPKEMLDQNSIFASITQQFLYLIENDHFTPNKN"
     gene            2471..2848
                     /locus_tag="VVO18_001437"
     CDS             2471..2848
                     /locus_tag="VVO18_001437"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1934 domain-containing protein"
                     /protein_id="HEU5586571.1"
                     /translation="MKIRMRNTIQFDEQLEVIDQLYDVEVHEKGDYSYLLFYNEEKEK
                     VVIKFHGQELVMSRFSNPKTIMRFLKNSDSLAYIPTPMGMQEFIIQTSHYQVDRQKIE
                     LDYQLQNQEGHPFASYQLEITWG"
     gene            2939..3271
                     /locus_tag="VVO18_001438"
     CDS             2939..3271
                     /locus_tag="VVO18_001438"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009660419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative DNA-binding protein"
                     /protein_id="HEU5586572.1"
                     /translation="MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEE
                     FGVSRQAVYDNIKRTEKILEDYEMKLHMYSDYIVRSQIFDQILERYPKDNFLQEQIEI
                     LTSIDNRE"
     gene            3283..4854
                     /gene="ffh"
                     /locus_tag="VVO18_001439"
     CDS             3283..4854
                     /gene="ffh"
                     /locus_tag="VVO18_001439"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal recognition particle protein"
                     /protein_id="HEU5586573.1"
                     /translation="MAFESLTERLQNVFKNLRKKGKISESDVQEATKEIRLALLEADV
                     ALPVVKDFIKKVRERAVGHEVIDTLNPAQQIIKIVDEELTAVLGSDTAEIIKSPKIPT
                     IIMMVGLQGAGKTTFAGKLANKLKKEENARPLMIAADIYRPAAIDQLKTLGQQIDVPV
                     FALGTEVPAVEIVRQGLEQAQTNHNDYVLIDTAGRLQIDELLMNELRDVKALAQPNEI
                     LLVVDAMIGQEAANVAREFNAQLEVTGVILTKIDGDTRGGAALSVRHITGKPIKFTGT
                     GEKITDIETFHPDRMSSRILGMGDMLTLIEKASQEYDEQKALEMAEKMRENTFDFNDF
                     IDQLDQVQNMGPMEDLLKMIPGMANNPALQNMKVDERQIARKRAIVSSMTPEERENPD
                     LLNPNRRRRIAAGSGNTFVEVNKFIKDFNQAKQLMQGVMSGDMNKMMKQMGINPNNLP
                     KNMPNMGGMDMSALEGMMGQGGMPNLSALGGAGMPDMSQMFGGGLKGKIGEFAMKQSM
                     KRMANKMKKAKKKRK"
     gene            complement(5049..6332)
                     /locus_tag="VVO18_001440"
     CDS             complement(5049..6332)
                     /locus_tag="VVO18_001440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007554578.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil permease"
                     /protein_id="HEU5586574.1"
                     /translation="MKQESTVDLLLDVDQRPSAGKGILLSFQHVFAMFGATILVPLIL
                     GMPVSVALFASGVGTLIYMIATGFKVPVYLGSSFAFITAMSLAMKEMGGDVSAAQTGV
                     ILTGLVYVLVATSIRFVGTKWIDKLLPPIIIGPMIIVIGLGLAGSAVTNAGLVADGNW
                     KNALVAVVTFLIAAFINTKGKGFLRIIPFLFAIIGGYLFALTLGLVDFTPVLEANWFE
                     IPGFYLPFSTGGAFKEYNLYFGPEAIAILPIAIVTISEHIGDHTVLGQICGRQFLKEP
                     GLHRTLIGDGIATSVSAFLGGPANTTYGENTGVIGMTRIASVSVIRNAAFIAIALSFL
                     GKFTALISTIPNAVLGGMSILLYGVIASNGLKVLIKERVDFAQMRNLIIASAMLVLGL
                     GGAILKLGPVTLSGTALSAMTGIILNLILPYENKD"
     gene            complement(6586..7299)
                     /gene="rsmG"
                     /locus_tag="VVO18_001441"
     CDS             complement(6586..7299)
                     /gene="rsmG"
                     /locus_tag="VVO18_001441"
                     /EC_number="2.1.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260112.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="HEU5586575.1"
                     /translation="MKPKTFYNLLAEQNLPLSDQQKEQFERYFELLVEWNEKINLTAI
                     TDKEEVYLKHFYDSIAPILQGLIPNETIKLLDIGAGAGFPSLPMKILYPELDVTIIDS
                     LNKRINFLQLLAQELDLNGVHFYHGRAEDFAQDKNFRAQYDFVTARAVARMQVLSELT
                     IPYLKVGGKLLALKASNAPEELLEAKNALNLLFSKVEDNLSYALPNRDPRYITVVEKK
                     KETPNKYPRKAGMPNKRPL"
     gene            7393..7953
                     /locus_tag="VVO18_001442"
     CDS             7393..7953
                     /locus_tag="VVO18_001442"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219838.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LemA family protein"
                     /protein_id="HEU5586576.1"
                     /translation="MTWIILGVLALVVIFVIVSYNGLVKNRMQTKEAWSQIDVQLKRR
                     NDLLPNLIETVKGYAKYEGSTLEKVAELRNQVAAATSPAEAMKASDALTRQVSGIFAV
                     AESYPDLKASANFVKLQEELTNTENKISYSRQLYNSVVSNYNVKLETFPSNIIAGMFG
                     FKAADFLQTPEEEKSVPKVDFSGLGD"
     gene            7955..8854
                     /gene="htpX"
                     /locus_tag="VVO18_001443"
     CDS             7955..8854
                     /gene="htpX"
                     /locus_tag="VVO18_001443"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc metalloprotease HtpX"
                     /protein_id="HEU5586577.1"
                     /translation="MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLV
                     IALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRIFI
                     IDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
                     ALASAITMLSSMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLV
                     QLAISRQREFLADASSVELTRNPQGMINALDKLDNSKPMSRHVDDASSALYINDPKKG
                     GGFQKLFYTHPPISERIERLKQM"
     gene            complement(8898..10424)
                     /locus_tag="VVO18_001444"
     CDS             complement(8898..10424)
                     /locus_tag="VVO18_001444"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU5586578.1"
                     /translation="MIKINHLTITQNKDLRDLVSDLSMTIQDGEKVAIIGEEGNGKST
                     LLKTLMGEDLSDFTIKGDIQSDYQSLAYIPQKLPEELKKKTLHDYFFLDSIDLDYSIL
                     YRLAEELHFDSNRFASDQEIGNLSGGEALKIQLIHELAKPFEILFLDEPSNDLDLETV
                     DWLKGQIQKTRQTVIFISHDEDFLSETADTIVHLRLVKHRKEAETLVEHLDYESYSEQ
                     RKAKFAKQSQQAANNQRAYDKTMEKHRRVKQNVETALRATKDSTAGRLLAKKMKTVLS
                     QEKRYEKAAQSMTQKPLEEEQIQLFFSDIQPLPASKVLVQLEKENLSIDDRVLVQKLQ
                     LTVRGQEKIGIIGPNGVGKSTLLAKLKQLLNDKREISLGFMPQDYHKKLQLDLSPIAY
                     LSKTGEKEELQKIQSHLASLNFSYPEMQHQIRSLSGGQQGKLLLLDLVLRKPNFLLLD
                     EPTRNFSPTSQPQIRKLFATYPGGLITVSHDRRFLKEVCSSIYRLTEHGLELVNLEDV
                     "
     gene            11183..11725
                     /locus_tag="VVO18_001445"
     CDS             11183..11725
                     /locus_tag="VVO18_001445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398453.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF177 domain-containing protein"
                     /protein_id="HEU5586579.1"
                     /translation="MKLNIQEIRKQSEGLNFEQTLDLVDDLRARNQEILDVKDILAVG
                     KVQYEDRMYFLDYQLSYTIVLASSRSMEPVELVESYPVTEVFMEGATNQLDQEVLDDD
                     LVLPIENGELDLAESVSDNILLNIPIKVLTAEEEAGQGFVSGNDWQIMTEEEYQAQQA
                     VKKEENSPFAGLQGLFDGDE"
     gene            11725..12354
                     /gene="nth"
                     /locus_tag="VVO18_001446"
     CDS             11725..12354
                     /gene="nth"
                     /locus_tag="VVO18_001446"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244461.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endonuclease III"
                     /protein_id="HEU5586580.1"
                     /translation="MVLSKKRARKVLEEIIALFPDAKPSLDFTNHFELLVAVMLSAQT
                     TDAAVNKATPGLFVAFPTPQAMSVATESEIASHISRLGLYRNKAKFLKKCAQQLLDDF
                     DGQVPQTREELESLAGVGRKTANVVMSVGFGIPAFAVDTHVERICKHHDIVKKSATPL
                     EVEKRVMDILPPEQWLAAHQAMIYFGRAICHPKNPECDQYPQLYDFSNL"
     gene            12565..13086
                     /gene="pyrR"
                     /locus_tag="VVO18_001447"
     CDS             12565..13086
                     /gene="pyrR"
                     /locus_tag="VVO18_001447"
                     /EC_number="2.4.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="HEU5586581.1"
                     /translation="MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVF
                     IAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYT
                     GRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTE
                     LDDQDRVLITEEA"
     gene            13105..14028
                     /locus_tag="VVO18_001448"
     CDS             13105..14028
                     /locus_tag="VVO18_001448"
                     /EC_number="2.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate carbamoyltransferase catalytic
                     subunit"
                     /protein_id="HEU5586582.1"
                     /translation="MSENQQALNHVVSMEDLTVDQVMKLIKRGIEFKNGAQLPYEDHP
                     IVSNLFFEDSTRTHKSFEVAEIKLGLERLDFDVKTSSVNKGETLYDTILTLSALGVDV
                     CVIRHPEVDYYRELIASPTITTSIINGGDGSGQHPSQSLLDLMTIYEEFGHFEGLKVA
                     IAGDLDHSRVAKSNMQILKRLGSELFFAGPEEWRSQEFADYGQFVTIDEIIDQVDVMM
                     FLRVQHERHDSGAVFSKEDYHAQHGLTQERYDRLKETAILMHPAPINRDVEIADHLVE
                     APKSRIVQQMTNGVFVRMAILESVLASRNAN"
     gene            14078..15157
                     /gene="carA"
                     /locus_tag="VVO18_001449"
     CDS             14078..15157
                     /gene="carA"
                     /locus_tag="VVO18_001449"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="HEU5586583.1"
                     /translation="MTKRILVLEDGTVFEGKAFGADIDVTGEIVFNTGMTGYQESITD
                     QSYNGQILTFTYPLVGNYGINRDDYESIIPTCKGVVVFEEARRASNWRNQMTLDEFLK
                     AKKIPGISGIDTRALTKIIRKHGTMRATLTHVGDSMDHVTDQLQATVLPTDNIKQVST
                     KTSYPAPGVGLSVVLVDFGLKHSILRELSKRNCNVTVVPYSTTAEEILHLNPDGVMLS
                     NGPGNPEDVPQALDMIRGVQGKIPIFGICMGHQLFAMANGAKTYKMKFGHRGFNHAVR
                     EIATGRVDFTSQNHGYAVSREDLPEHLIITHEEINDKSVEGVRHRYQPAFSVQYHPDA
                     APGPHDASYLFDEFIEMMEVFKQSN"
     gene            15470..18646
                     /gene="carB"
                     /locus_tag="VVO18_001450"
     CDS             15470..18646
                     /gene="carB"
                     /locus_tag="VVO18_001450"
                     /EC_number="6.3.5.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803305.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="HEU5586584.1"
                     /translation="MPKRTDIQKIMVIGSGPIIIGQAAEFDYAGTQACLSLKEEGYEV
                     VLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKEGPDALLPTLGGQTGLNMAMEL
                     SKNGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFAA
                     TIGYPVIVRPAFTLGGTGGGMCANEKELREITENGLKLSPVTQCLIERSIAGFKEIEY
                     EVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPAQTMSDYENQMLRDASLSIIRALK
                     IEGGCNVQLALDPNSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEV
                     INPVTGSTYAMFEPALDYVVAKIPRFPFDKFEKGERRLGTQMKATGEVMAIGRNIEES
                     LLKACRSLEIGVHHNEIPELAAVSDDALIEKVVKAQDDRLFYVSEAIRRGYTPEEIAE
                     LTKIDIFYLDKLLHIFEIEQELGAHPQDLEVLKTAKLNGFSDRKIAELWGTTDDKVRQ
                     LRLENKIVPVYKMVDTCAAEFDSETPYFYSTYGWENESIRSDKESVLVLGSGPIRIGQ
                     GVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIDL
                     EQPKGVIVQFGGQTAINLAEPLAKAGVTILGTQVADLDRAEDRDLFEQALKELDIPQP
                     PGQTATNEEEAALAARKIGFPVLVRPSYVLGGRAMEIVENEEDLRSYMRTAVKASPDH
                     PVLVDSYIVGQECEVDAISDGKNVLIPGIMEHIERAGVHSGDSMAVYPPQTLSQKVQE
                     TIADYTKRLAIGLHCLGMMNIQFVIKDEKVYVIEVNPRASRTVPFLSKVTNIPMAQVA
                     TKLILGQSLSELGYQNGLYPESTRVHIKAPVFSFTKLAKVDSLLGPEMKSTGEVMGSD
                     ATLEKALYKAFEASYLHLPTFGNVVFTIADDAKEEALNLARRFQNIGYGILATEGTAA
                     FFASHGLQAQPVGKIGDDDKDIPSFVRKGRIQAIINTVGTKRTADEDGEQIRRSAIEH
                     GVPLFTALDTANAMLKVLESRSFVTEAI"
BASE COUNT         5449 a         3605 c         4184 g         5457 t
ORIGIN      
        1 cctaatttgt ataattgatt gtgtgtagat tcagggtcaa tttgaagaga gtatttaaaa
       61 tatcttggga aattataatt tctccctgtt ttttgagtcc aatctatgag tatgagttgc
      121 ccaggagtaa ggccgcactc taatttgttt aggtaaaaat tgttacaatc agaatttgtg
      181 tctctattat gattattttg ttttaaatta aatagtttgc taaaaaaatt cattggattt
      241 tattgctaat caattcttat tgaaaaatga tacttttaca gtacccatgt acggatggca
      301 tgggcaacgc cagattcatc attagattta gtgatgtatt tggcgatttt tttgatttct
      361 ggatttccat tttccatgac aacagggttg ccaacgactt ccagcatggc acggtcattt
      421 tcttcgtctc cgatagccat ggtttcatct ttggttaatc ctagtttttc agctaagtga
      481 gtaatagctg aacccttgtc tacattcttt ttaaggagtt cgaggtagaa aggagcagat
      541 ttgttgatag agtagtgctc gtaaaattcg gctggtattt tttcaatcgc agcatcgaga
      601 atttctggtt catcgataaa catacattta acaatttctt tgccagccat ttcttcaggg
      661 gtacggtaga agataggcat gctgacgagg gttgattcgt gtacagtgta tgttccgata
      721 ttgcgatttg cagtatagat accgtccttg gtaatggcat gcatgtggac accgagcttg
      781 cgactgagga attccatatc cagataatcc tcataggtca aggattcgct gataatctca
      841 tggccagtag cagtttcttg gacaagggca ccattgaagg tcaccacata gtcaccttgg
      901 tctctcaact gcaagtcgtc tagaagtttg gcaacacctg cgatggggcg gccagttgca
      961 atcacgactt tgacaccagc ttctttggca tcttggatgg cagaaaagac ttcaggagtg
     1021 atttcctttt ggctgttgac aagggttccg tcgatatcaa cggcaattag tttaatactc
     1081 ataaatttcc tcttctagtt tttatttggg gtaaaatgat cgttctcaat caagtataaa
     1141 aattgctggg taatgctagc aaagatactg ttttgatcta acatttcttt cggaaaatag
     1201 aaacgattat ctccgtgacg actaccagca agggattgga cgataggaga caggctagag
     1261 agttcggcca gttctccatt cttttgtaaa atctcaatct gtgtccgtgg attttcagat
     1321 tcgggacgat agatatcata agggaggtca aagttcttat gaatggcagt atagtagtcg
     1381 ggatcaaagc caatgtcctc aaccaatttt ctcatgctag cgagttggtc ttgatcttct
     1441 tgtgaaaagg taatggattt aaagaccttg cggttgacaa agcgttgcga taaatctgcg
     1501 agaattttgt caggactggt catccagagc tggaagtagg tattcatcac accatcatct
     1561 agagccagat agtcagacaa ggtcacattt ttttcaaaga aaggcaggag gtgtggggaa
     1621 gttcgtgcaa agaagtcttt gtccttaggg tagagttcct tagcgcgctt gagaagattc
     1681 tgtaggagaa cttccatagc gcgtgttgct gggtggaaat agacctgcat atacatctgg
     1741 tagcgactga ggacatagtc ttcgatggcg tgcatgccat tgcgctgaaa ggcgatacca
     1801 ttttcgatag gacgaatgac tcggaggatt cgagtcaggt caaattcccc ataggatgct
     1861 cctgtaaaat aggagtcacg caagagatag tccatgcgat ctgcgtcaat ctgactagaa
     1921 atgagttgta cgacctgctt gttaggatag gtatggtcta tgacactggc aactttctct
     1981 ggaaaatcgg gcgctacttg tagcaagact tggtgaatct ctgtctcagg actttgaata
     2041 atctcctgag taatagcttc atggtctgta tcaaagagat gttcaaaagt atgggagtag
     2101 gcgccatgcc caaggtcatg taggagagca gcgatcatgg tcaagagaga ctcggcagga
     2161 ttccattcct caggatattt ttcttcgaaa atctctgtga tgcgtcgtgc aatttcatag
     2221 actcctagac agtgagagaa gcgactgtgt tctccaccgt ggaaggtata actggaagtt
     2281 cccagttgtt tgatccggcg caaacgctga aattcttttg tattaatcaa gtcatagatg
     2341 atttgattat tgacatggat gtagttgtga actgggtcac ggaatacttt ttcgttcata
     2401 tgaccattat agcaaaatcc tgctcttttt ggtaaaatag taggacaaga gacaagaaag
     2461 agggcctgat gtgaagattc ggatgcgaaa tacaattcag tttgatgagc agttggaagt
     2521 gattgaccag ctttatgatg tggaagtgca tgaaaaagga gattatagct acctgctttt
     2581 ctataatgag gaaaaggaaa aagtagtgat taaatttcat ggtcaagaac ttgtgatgag
     2641 ccgattttct aatcccaaga ccattatgcg ctttctaaag aatagcgata gtttagccta
     2701 tattcctaca cctatgggca tgcaggagtt tatcatccaa acgagccatt atcaagttga
     2761 taggcaaaag attgaactag attatcaact acaaaatcaa gagggacatc cttttgccag
     2821 ctatcaattg gaaattactt ggggctaggc tcatgtcttt ttcaaattta gctatctatc
     2881 ttcttggatc ggcttcctag tgtggtagat taggctaatt tttggtataa taaaagttat
     2941 ggaaatcgaa aaaaccaatc gtatgaatgc gctctttgaa ttttatgcgg cgcttttgac
     3001 agataagcaa atgaattata tcgagctcta ctacgctgat gattacagcc ttgctgaaat
     3061 tgccgaggag ttcggtgtca gtcgtcaggc tgtctatgac aatatcaagc gaacagaaaa
     3121 gattctggaa gattatgaga tgaaattgca catgtactcg gactatattg tccgcagtca
     3181 gatttttgat cagattttgg agcgctatcc caaggataac tttctgcagg agcagataga
     3241 aattttaaca agcattgata atagagaata agaggaagaa aaatggcatt tgaaagttta
     3301 acagaacgtt tgcagaacgt ctttaaaaat ctacgtaaaa aaggaaaaat ctctgaatct
     3361 gatgtccaag aggcaaccaa agaaattcgc ttggccttgc tcgaggccga cgttgccttg
     3421 cctgttgtaa aggactttat caagaaagtt cgtgagcgtg cagtcgggca tgaggtcatt
     3481 gatacactta atcctgcgca acagattatt aaaatcgttg atgaggaact gacagccgtt
     3541 ttaggttctg atacggcaga aattatcaag tcacctaaga ttccaaccat catcatgatg
     3601 gttggtttac aaggggctgg taaaacaacc tttgctggta aattggccaa caaactcaag
     3661 aaagaagaaa atgctcgtcc tttgatgatt gcggcggata tttatcgtcc agctgccatt
     3721 gaccagctta agaccttggg acaacagatt gatgtgcctg tctttgcact tggaacagaa
     3781 gtaccagctg ttgagattgt acgtcaaggt ttggagcaag cccaaactaa tcataacgac
     3841 tatgtcttga ttgatactgc gggtcgtttg cagattgatg agctcctcat gaatgagctt
     3901 cgtgatgtga aagcattggc tcaaccaaat gaaatcttgc ttgtcgttga tgctatgatt
     3961 ggtcaggaag cagccaatgt tgcgcgtgag tttaatgctc agttggaagt gactggggtc
     4021 atccttacca agattgatgg cgatactcgt ggtggtgcgg ctctatcggt tcgtcacatc
     4081 actggaaaac caatcaagtt cactggtaca ggtgaaaaaa ttacagatat cgaaaccttc
     4141 cacccagacc gtatgtctag ccgtatcctt ggcatggggg atatgctcac tttgattgag
     4201 aaagcttctc aggaatacga tgaacaaaaa gcccttgaaa tggctgagaa gatgcgcgaa
     4261 aacacctttg attttaatga tttcatcgat caattagatc aggtgcaaaa tatggggccg
     4321 atggaagact tgctcaagat gattccaggt atggccaaca atccagcact tcaaaacatg
     4381 aaggtggatg aacgccagat tgctcgtaaa cgtgccattg tgtcttcgat gacacctgaa
     4441 gaacgtgaaa acccagattt gttaaatcca aaccgtcgcc gtcgtattgc tgctggttct
     4501 ggaaatacat tcgtcgaagt caataaattc atcaaggact ttaaccaggc taaacagctc
     4561 atgcagggtg ttatgtctgg ggatatgaat aaaatgatga agcaaatggg gattaatcca
     4621 aataaccttc ctaaaaatat gccaaatatg ggaggaatgg atatgtctgc ccttgaagga
     4681 atgatgggac aaggcggtat gcctaactta tcagctctcg gaggagcagg aatgccagat
     4741 atgagccaga tgtttggtgg cggtttgaaa ggtaaaattg gtgaatttgc catgaaacag
     4801 tccatgaaac gtatggctaa caaaatgaag aaagcgaaga agaaacgcaa gtaagacaag
     4861 agattgatgc aaatctcatt tgatgagaaa ataaagtaaa aatttctatg ataaaacgca
     4921 cagtatcaag gttttagaat atctgatatt atacgttttt tgattttaat aattttgtta
     4981 agacactttt attatggtat acgaaaaatc cactcagctg tctgagtgga ttaggtgtat
     5041 ttagactctt agtctttatt ttcgtatggc aagatcaagt tcaagatgat tcctgtcatg
     5101 gctgaaaggg cagtacctga aagtgtaact ggaccaagtt taaggatagc tcctccaagt
     5161 ccaagaacca acatagcact tgcgatgatg aggtttcgca tttgagcgaa atcaacacgt
     5221 tctttaatca agactttcaa accattgctg gcgataaccc catagagaag gattgacata
     5281 ccaccaagta cagcgtttgg aatagttgaa atcaaggcag tgaatttacc aaggaagctg
     5341 agggcaatcg cgatgaaggc agcgttacgg ataactgaga cagaagcgat acgagtcata
     5401 ccgataaccc ctgtattttc tccgtaagtt gtattggctg gtccaccaag gaaggcagaa
     5461 acagaagttg cgataccgtc accaataaga gtacggtgaa gacctggttc ttttaagaat
     5521 tgacggccac agatttgacc caaaacagta tggtctccga tatgttcaga aattgttacg
     5581 atagcgattg gcaagatagc gatggcttct ggaccaaagt aaagattgta ctctttaaag
     5641 gcaccacctg tgctaaatgg caagtagaaa ccaggaattt caaaccagtt agcttctagg
     5701 acaggcgtaa agtcaaccaa accaagagtt agtgcgaaga ggtaaccacc gataatggca
     5761 aagaggaatg gaatgattcg taggaagcct tttccttttg tattgataaa ggcagcaatt
     5821 aggaaagtaa caacggctac cagagcattt ttccaatttc cgtctgctac aagacctgca
     5881 ttggtaacag ctgaacctgc aagtccaaga ccgataacga tgatcatagg accgataatg
     5941 attggtggca agagtttatc aatccatttt gttcctacaa atcggatgct ggtagcaaca
     6001 aggacataga ccaaaccagt caagataacc cctgtttggg cagcagatac atcccccccc
     6061 atttctttca tagccagtga catagctgtg ataaaggcga atgaagaacc tagataaact
     6121 ggaactttaa aaccagtagc aatcatgtag atgagtgttc caacacctga agcaaaaagg
     6181 gcaacagata caggcattcc caaaatcaat ggtaccaaga tggtcgcacc aaacatggcg
     6241 aaaacgtgtt ggaaactaag gagaattcct tttccagccg aaggacgttg gtcaacgtct
     6301 agtaacaaat caacagttga ttcttgtttc atataaacct cacttttggg catcaaaaaa
     6361 gagcccatta ttttacagca ataggccctc agagtaagac ttctttaaaa tttagatttt
     6421 aaagagtttt aaatatttct gcgtcttcgt cacctcacgg gatgacatta aaaacctttg
     6481 cttaggatag tatagcagaa aaaaatgatt ttgtaaatca ttttttcccg agcctagaaa
     6541 taaaagagcg aggctgattt tgtaaacctt tgtttactaa aaaatttaaa gtgggcgttt
     6601 atttggcata ccagccttac gtggatattt atttggtgtt tcttttttct tttctaccac
     6661 tgtgatatag cgcggatctc tattcggtag ggcgtagctg agattgtctt cgaccttact
     6721 aaaaaggaga ttgagggcat tcttagcttc taataattcc tcaggcgcat tgctagcctt
     6781 gagtgctaat agtttgccac caaccttaag gtagggaata gtcaattcag ataggacctg
     6841 catacgggca accgcacgag ctgttacaaa atcatattga gcacggaagt tcttgtcttg
     6901 ggcaaaatct tcggcacgtc cgtggtagaa atgaactccg ttcaaatcca gttcttgagc
     6961 caagagttgt aggaagttga tgcgcttatt gagtgaatca ataatggtca catctaactc
     7021 cggatagaga attttcattg gtagactcgg aaatcctgcc ccagccccga tatcaagaag
     7081 tttgatagtt tcattgggaa tcaaaccttg aagaatgggt gcaatcgaat cgtaaaaatg
     7141 tttgagataa acttcttcct tgtccgtaat cgccgtcaaa ttaatcttct cattccactc
     7201 gaccaagagc tcaaaataac gttcaaattg ttctttttgc tggtccgaaa gtggaagatt
     7261 ctgctcggca agcaagttgt aaaatgtttt tggtttcata gttatttcct tctttagtat
     7321 catcttattt taccacaatc atagaaaatt tgatatactg gtactaatct aaaagcagaa
     7381 aggacttata ttatgacttg gattattctt ggagttttag ctcttgttgt tatttttgtg
     7441 attgttagct ataacggttt ggttaaaaat cgtatgcaaa ccaaggaggc ttggagtcag
     7501 attgatgttc agttgaaacg tcgcaatgat ctcttgccaa acttgattga gactgtaaaa
     7561 ggttatgcca aatatgaagg ttctaccctt gaaaaggtgg cagaactacg taaccaagtg
     7621 gcggcagcga cttcaccagc agaagctatg aaagccagtg atgccctcac tcgtcaggtt
     7681 tcaggtattt ttgcagttgc agaaagctat ccagatttga aagctagtgc taactttgtt
     7741 aaattgcaag aggagttgac aaacacagaa aataaaattt cttactctcg tcaactctat
     7801 aacagtgttg tcagcaacta caatgtaaaa ttagaaactt tcccgagcaa tattatcgct
     7861 ggaatgtttg gatttaaagc ggcagatttc cttcaaacac ctgaagagga aaagtcggtt
     7921 cctaaagttg attttagcgg tttaggtgac taagatgttg tttgatcaaa ttgcaagcaa
     7981 taaacgaaaa acctggattt tgttgctggt atttttccta ctcttagctc ttgttggtta
     8041 tgcggttggt tatctcttta taagatctgg acttggtggt ttggttatcg cactgattat
     8101 cggctttatc tacgctttgt ctatgatttt tcaatcgaca gagattgtca tgtccatgaa
     8161 tggagcgcgt gaggtggatg agcaaacggc accagacctc taccatgtag tggaagatat
     8221 ggctctggtc gctcagattc ctatgccccg tattttcatt attgatgatc cagccttaaa
     8281 tgcctttgcg acaggttcta atcctcaaaa tgcggctgtt gctgcgactt caggtctact
     8341 agctatcatg aatcgtgaag aactagaagc tgttatggga catgaagtca gtcatattcg
     8401 taattatgat atccgtattt cgactattgc agttgccctt gctagtgcta tcaccatgct
     8461 ttctagtatg gcaggtcgta tgatgtggtg gggtggagca ggtcgcagac gaagtgatga
     8521 tgaccgagat ggaaatggtc ttgaaatcat tatgctagtg gtttccctac tagctattgt
     8581 actggcacct ctcgctgcaa ccttggttca gctcgctatt tctcgtcaga gggaatttct
     8641 ggcagatgca tctagtgtcg agctgactcg caatccccag ggaatgatta atgccctaga
     8701 taagttggac aatagcaaac ctatgagtcg ccacgtcgat gatgctagca gtgctcttta
     8761 tatcaatgat cccaagaaag gtggggggtt ccaaaaactc ttttataccc acccacctat
     8821 ctcagaacgg attgaacgtt taaaacagat gtaaaagaat ccagaggtcg tctctggatt
     8881 tttgctatgt tgcaaattta tacatcttct aaattaacta actccaaacc gtgttctgtc
     8941 aagcggtaga tgcttgaaca gacctctttt aagaaacgac ggtcatgcga aacagtgatg
     9001 agaccgcctg gataggttgc aaagagtttt ctgatttggg gttgagaagt gggagaaaag
     9061 tttcgtgtgg gttcatccag caggagaaag tttggtttgc gcaggactaa atccaaaagc
     9121 aggagttttc cctgttgtcc gccagataag gagcgaattt gatgctgcat ttctggataa
     9181 ctgaaattga gactagctag gtgagattgg attttctgta gttcctcttt ttccccagtt
     9241 ttgctgaggt aggctattgg tgataaatcc aattgcagtt ttttgtggta atcttgtggc
     9301 ataaaaccaa gggaaatctc tcttttatca ttcagaagtt gctttaattt ggctaacaga
     9361 gttgatttcc caacaccatt tggcccgata ataccgattt tttcttgccc acggacagtt
     9421 agttgtagtt tttgaaccaa aactcggtcg tcaatggaca aattttcttt ttccagttgg
     9481 actaagactt tagaagctgg taatggttgg atgtctgaaa agaaaagttg gatttgttcc
     9541 tcttcaagtg gcttttgagt catggactga gctgcctttt cgtagcgttt ttcttgtgag
     9601 aggacagttt tcatcttttt agccaatagg cgaccggcag tactgtcttt ggtagctcga
     9661 agcgcagttt ctacattttg tttgactctc cgatgttttt ccatggtttt atcgtaggct
     9721 ctttggttgt tagcagcttg ctgactttgt ttggcaaatt tagcctttct ctgctcacta
     9781 tagctttcat agtctaaatg ctctactagc gtttccgctt ctttacggtg tttgaccagt
     9841 cgcaagtgaa caatagtgtc tgccgtttca gaaagaaagt cttcatcatg ggaaatgaaa
     9901 ataacggttt gcctggtctt ttgaatctgg ccttttaacc aatcaactgt ctcaaggtct
     9961 aggtcatttg aaggttcatc taaaaataga atctcaaagg gtttggctaa ctcatggata
    10021 agctgaattt tcaaagcttc tccccctgat agattgccaa tctcttggtc acttgcgaaa
    10081 cgattgctat caaaatgcaa ttcctccgcc aaacgataga ggatactgta gtctaaatca
    10141 atagaatcta aaaagaagta gtcgtgtaaa gttttctttt tcagctcctc gggaagtttt
    10201 tgaggaatgt aggccagtga ctgataatca gactggatgt ctcccttgat agtgaaatca
    10261 gacaaatctt cccccattaa agttttaagt aaggttgatt taccatttcc ttcttcgcca
    10321 ataatagcta ccttttcccc gtcttgtatg gtcatgctta ggtcagagac aaggtctcgt
    10381 aaatctttgt tttgtgtgat ggtcaggtga ttgattttta tcataactat tgccctttct
    10441 agaatgttca tagtgcataa caaaaagctc tactttacct agtagagccc aaagtctatg
    10501 tcaaaaaaac tctattaaca tgccagaaaa agggcataaa agagcacaca aaaagagaca
    10561 aaaacaagat ctactaaata aaggttcttt atttgataga cttagttgtt catgtctccc
    10621 ttacctccta gtattagtat ctttatacta tacttttaag gaaattttgt caacagaaaa
    10681 ctggaaattc tatgctctaa aatccaaaaa caggtctata gagacttagt acgtgtttga
    10741 catgctcgta atggatttta tcatagtttc gccaagcagt gcgttcttga ttgtttagtt
    10801 ttaggctacc cagtccaatc ataggactgg tgggttggta aaatttctca agatcaatta
    10861 agatactgtt gttcaacttt tccgtttttt gagttcttgc atagtagtgt ttagcagctc
    10921 ttgtagtcga atatcatctg ccgtaccctg tttacagttt tggtagcttt tatttaactt
    10981 ggataggagt tgaatgagtt tcttgtcttc cgtgtgagca tcctccttga tctgatgtac
    11041 tctttcccta tagtatagca ctaaaaaata aaactgtcat agtgaatatg ttaaaatttc
    11101 gaattttaat tacaaagttt ggtgtgctga tttgtagcct tttcatggta taatcaagag
    11161 agtaaatctt tatggaggaa gtatgaaatt aaatattcaa gaaattcgta agcagtctga
    11221 aggtttgaac tttgaacaaa cgttagattt agttgatgac ctgcgtgcac gtaatcaaga
    11281 aattttagat gtaaaagata tccttgcagt tgggaaagta caatatgaag accgtatgta
    11341 tttcttagat tatcaactat cttataccat tgttcttgct tcgagtcgca gtatggagcc
    11401 agttgagtta gttgaatctt atccagtcac ggaagttttc atggaaggcg caactaacca
    11461 gctagatcaa gaagttttag atgatgactt ggtcttgccc atcgaaaatg gggagcttga
    11521 ccttgctgag agtgtatcag acaatatcct gctaaacatt cctatcaagg tcttgacggc
    11581 tgaagaagaa gctggtcaag gatttgtctc aggaaatgac tggcaaatca tgacagagga
    11641 agaataccaa gctcaacaag cagtaaagaa agaagaaaac agtccttttg ctggcttaca
    11701 aggactattt gacggagatg aataatggtc ttgtcaaaaa aacgagcacg aaaggtgcta
    11761 gaagaaatca ttgccctctt cccagatgcc aagcctagtc ttgattttac caatcatttt
    11821 gaactcctgg ttgcggtcat gttatcagcc cagacgacag atgcagcggt aaataaggcc
    11881 acaccaggtc tctttgttgc ctttccaaca ccccaagcta tgtctgtagc gacagagagt
    11941 gagattgctt cacatatttc tcgcttggga ttgtatcgga ataaagctaa attccttaaa
    12001 aaatgtgccc aacagttact agacgatttt gatggtcaag tccctcagac acgtgaagaa
    12061 ttggagagtt tggcaggtgt tggtcgcaag acagccaatg ttgtcatgag tgtaggattt
    12121 gggattccag cctttgcagt ggatactcat gtggagcgta tttgcaaaca ccacgatatt
    12181 gtcaaaaaat cagcgacgcc acttgaggtg gaaaagcggg tcatggatat cttgccgcct
    12241 gagcagtggt tagctgccca tcaggccatg atttattttg gaagagccat ttgccatcca
    12301 aaaaatccag agtgtgacca gtacccacaa ttatatgatt ttagcaattt gtaagatgct
    12361 acattgaaac tttttgcttg attttaagca tgctttgtgc tatagtaaat gataactaaa
    12421 tattccttta aacctgtccc gtgaggcagg caaggagcgc gataaagtag aagggtgaag
    12481 tctatactgt gtgcagtagg gctcgcttgg ctataaattt caagtctcct tgtttaagga
    12541 gacttttctt tttggaggtt tgtcatgaaa acaaaagaag ttgtagacga attgaccgtc
    12601 aaacgagcga ttacgcgtat tacttatgag attatcgaac gcaacaaaga tttgaataag
    12661 attgtcttgg ctggtattaa aactcgtggt gtctttattg cccaccgaat ccaagaacgt
    12721 ttgaagcagt tagaaaatct ttcagttcct gttgtggaat tggatactaa acctttccgt
    12781 gatgatgtta aaagtggaga agatacttct ttggtttctg tcgatgtgac agaccgcgaa
    12841 gttatcttgg tggatgatgt gctctataca ggtcgtacca tccgtgctgc tattgataat
    12901 attgtcggtc atggtcgtcc tgcgcgtgtg agtttagcag ttctagtcga tcgtggacat
    12961 agagaattgc caatccgtcc agattacgtt ggaaaaaata tcccaaccag tcgttctgaa
    13021 gaaatcatcg tagagatgac agaacttgat gaccaagaca gagttctgat tactgaagaa
    13081 gcttagaaag ttaaaggagt agccatgtca gaaaatcaac aagcattgaa ccatgtggtg
    13141 tccatggaag acctcactgt cgatcaagta atgaaattga tcaagcgagg aattgagttt
    13201 aaaaatggag cccagcttcc ctatgaagac catccgattg tttccaatct cttctttgag
    13261 gattctacac ggacacataa gtcctttgaa gtcgcagaga ttaaacttgg attggaacga
    13321 cttgactttg atgtgaagac tagttcggtt aataagggtg agacacttta tgacaccatt
    13381 ttgactctgt ctgctttagg agtggatgtc tgtgtgattc gccatccaga ggtcgactac
    13441 tatagagaat tgattgctag tccaacgatt acgacttcca tcatcaatgg tggagatggt
    13501 tcgggccaac accctagcca gagcttgctt gatttgatga ccatttatga ggaatttggc
    13561 cactttgagg gtcttaaagt tgctattgca ggtgacttgg accactcacg cgttgccaaa
    13621 tccaatatgc agattttgaa acgcttggga tctgaactct ttttcgctgg acctgaggaa
    13681 tggagaagtc aagagtttgc agactatgga cagtttgtaa ccattgatga aatcattgat
    13741 caggttgatg tcatgatgtt tctccgtgtg caacacgaac gccatgatag tggagctgta
    13801 ttttcaaaag aagactacca tgcccaacat ggcttgactc aagaacgtta cgatcgtttg
    13861 aaagaaacag caatcctcat gcacccagct ccaatcaatc gtgatgtaga aatagcagac
    13921 cacttggttg aagcaccaaa atcacggatt gtccaacaaa tgaccaatgg tgtctttgtt
    13981 cgaatggcaa tcttagaatc cgtactagcg agtagaaacg ccaactaaaa cacaagacgt
    14041 taaaagacgc cagtgagcgt ccacgagagg tgaaaatatg acaaaaagaa ttctagtatt
    14101 agaagatggc acagtttttg aaggcaaggc cttcggagca gatattgatg taacaggcga
    14161 aatcgtcttt aatacaggga tgaccggcta ccaagaatcc attacagacc agtcttataa
    14221 tggacaaatc ttgaccttta cttatccttt ggtaggaaat tatggtatta atcgtgatga
    14281 ttatgaatcc attattccaa cttgtaaggg agtcgttgtt tttgaagaag cgcgtagagc
    14341 tagcaactgg cgcaaccaaa tgaccttgga tgaatttttg aaagccaaga aaattccagg
    14401 gatttcagga attgatacgc gtgctcttac caagattatc cgtaagcatg gtactatgcg
    14461 tgcaaccttg acccatgttg gggacagtat ggaccatgtg acggaccagc tccaagcaac
    14521 agttttaccg acagacaata tcaaacaggt ttctactaaa acgtcttatc cagctccagg
    14581 agttggtttg agcgtggtgc tagtggactt tggtctcaag cactcaatcc tacgtgaact
    14641 ttctaaacgc aactgtaacg tgacagttgt tccttattcg acaacggctg aagaaattct
    14701 ccatctcaat cctgacggag ttatgttgtc aaatggtcca ggtaacccag aagacgttcc
    14761 acaagcactc gacatgattc gcggtgtaca aggaaaaatt ccaatctttg gtatttgtat
    14821 gggacaccaa ctctttgcaa tggcaaacgg ggctaagacc tataagatga agtttggcca
    14881 ccgtggattc aaccatgcgg tacgtgaaat cgcaacagga cgagtagact tcaccagcca
    14941 gaaccatggt tatgcagtca gccgcgagga tttgccagag cacttgatta ttacccacga
    15001 agaaatcaat gacaagtcag tggaaggtgt gcgccacaga taccaacctg ctttctctgt
    15061 tcaataccac ccagatgcag ctcctgggcc acacgacgct agctacctat ttgacgagtt
    15121 tatcgagatg atggaagttt ttaaacaatc aaactaagaa cgagtaaaag ctcgtcggag
    15181 aatttatgta actgaacacg gacggaaagc tcagaatgta gagaaaccaa cttggattgt
    15241 caatccttcc ttgatttcct aaaattcaat cgctttctat tcgtcctttg tatcttattt
    15301 aatgtcgccc tgagaggcga cgaatagaaa ggagaagggt gctccgtatt tgctgaactg
    15361 aatacgggct acggacggtg ctaaaaagat agttattcct agaactgaca gttcttcgtc
    15421 ataactccta ttttagcttt gtccgcttga cacccttaat atcttatata tgcctaaacg
    15481 tactgatatt caaaaaatta tggtgattgg ttctggtccg attattattg gtcaggctgc
    15541 tgagtttgac tacgctggga ctcaggcttg cttgtcgttg aaagaggaag gttatgaggt
    15601 tgttttggtt aactcaaatc ctgcaaccat catgacggac aaggaaattg ctgacaaggt
    15661 ttacattgaa ccgattacac ttgagtttgt gacacgtatt cttcgtaagg aaggtccaga
    15721 tgccttgcta ccaacactcg gtggtcagac aggtctcaac atggccatgg aattatctaa
    15781 aaatggtatc ctagacgagc ttggcgttga acttctgggt accaaattat ctgccattga
    15841 ccaagcggag gaccgtgacc tctttaaaca attgatggaa gagcttgaac aacccattcc
    15901 agaatctgaa attgttaaca cagtagaaga agcagttgcc tttgcagcga caattggcta
    15961 cccagtcatc gttcgtccag cctttaccct tggtggtact ggtggtggta tgtgtgccaa
    16021 cgagaaagaa ttgcgtgaaa tcactgaaaa tggtttgaaa ttgtcacctg ttacccaatg
    16081 tttgattgag cgttcgattg ccggtttcaa ggaaattgaa tacgaagtga tgcgtgactc
    16141 agctgacaat gccttggttg tttgtaacat ggaaaacttt gacccagttg ggattcacac
    16201 aggggattcc attgtatttg cccctgcgca aaccatgtca gactatgaaa accaaatgct
    16261 tcgtgatgcg agcttgagca ttattcgtgc cctcaagatt gaaggtggat gtaatgttca
    16321 gctagctctt gatcctaaca gcttcaagta ttatgttatc gaagtaaacc ctcgtgtatc
    16381 acgttcgtca gcccttgctt ctaaagcgac aggatatccg attgctaagt tggctgccaa
    16441 gattgcagta ggtttgacct tggatgaggt tataaaccca gttacaggtt caacctatgc
    16501 catgtttgaa ccagcccttg actacgtagt tgctaagatt ccacgtttcc catttgacaa
    16561 gtttgaaaag ggtgaacgcc gtctcggtac acaaatgaag gcgactggag aagtcatggc
    16621 aatcggtcgt aacatcgagg aatctcttct caaggcctgc cgctcccttg aaattggggt
    16681 gcaccacaat gaaatacctg aacttgcagc agtttctgat gatgccttga ttgaaaaggt
    16741 tgtcaaagcc caagatgacc gtctcttcta cgtatcagaa gccattcgtc gtggctacac
    16801 acctgaagaa attgcagagc ttacaaaaat tgatatcttc tatcttgata aactcttgca
    16861 tatctttgaa attgagcaag aattgggtgc tcatccacaa gatctagaag ttttgaaaac
    16921 agccaaactt aatggttttt cagaccgtaa gattgctgaa ctctggggaa cgactgatga
    16981 taaagttcgc caacttcgct tggaaaacaa gattgttcca gtttataaga tggtagacac
    17041 ttgtgcggca gagttcgact ccgaaacgcc atatttctat tcaacctatg gttgggaaaa
    17101 tgaatctatc agatctgata aagaatctgt acttgtccta ggttcaggtc caatccgtat
    17161 cggtcaaggg gttgagtttg actacgcaac cgttcactct gttaaggcta tccaggcagc
    17221 tggttatgaa gctatcatca tgaactcaaa cccagagacc gtttcaacag acttctctgt
    17281 atcagataag ctttactttg agccattgac attcgaagat gttatgaacg tcattgactt
    17341 ggaacaacca aagggagtta tcgttcagtt cggtggtcaa acagccatca accttgcgga
    17401 gccattggca aaagcaggtg tgaccatcct tggtacacag gttgctgacc tagaccgtgc
    17461 cgaagaccgt gacctcttcg agcaagctct caaagaattg gatattccac agccaccagg
    17521 acaaacggct accaatgaag aagaagcagc tcttgcagct cgtaagattg gcttcccagt
    17581 tcttgtccgc ccatcttatg tacttggtgg acgtgccatg gaaatcgttg aaaacgaaga
    17641 agaccttcgt tcttacatgc gaactgctgt taaggctagt ccagaccatc cagttcttgt
    17701 cgactcttat atcgttgggc aagagtgcga agttgatgcc atttcagatg gtaaaaatgt
    17761 actcattcct ggtatcatgg agcatatcga acgtgctggt gtccactcag gtgactcaat
    17821 ggctgtttac ccaccacaaa ccttgtcgca aaaggttcag gagaccatcg cagactacac
    17881 caaacgctta gcaatcggtc ttcactgcct tggaatgatg aacatccagt ttgttatcaa
    17941 ggatgaaaaa gtctacgtta ttgaggtcaa tccacgtgcc agccgtaccg ttccattcct
    18001 atctaaggta accaatattc ctatggctca agtagcgacc aagctcattc ttggtcaaag
    18061 tttatcagaa cttggctacc aaaatggact ttaccctgaa agcacccgtg ttcatatcaa
    18121 ggcacctgtc ttctccttta ccaaactagc taaggtagac agcttgctcg gtcctgaaat
    18181 gaagtcaaca ggtgaagtta tgggttctga tgctactttg gaaaaagctc tctataaagc
    18241 ctttgaagct tcttatctac acttgccaac ttttggtaat gtcgtcttta ccatcgctga
    18301 tgatgccaaa gaagaagcct tgaacttggc tcgtcgtttc caaaacattg gttatggaat
    18361 ccttgcgaca gaagggacag cagccttctt tgctagtcat ggcttgcaag cccaacctgt
    18421 tggtaagatt ggtgatgacg ataaggatat cccaagtttt gtacgcaaag gaagaattca
    18481 agctatcatt aacacagtag gaacaaaacg aactgctgac gaagatggtg agcaaattcg
    18541 tcgttcagcc attgaacacg gggtgcccct cttcacagcg ctagatacag ctaatgccat
    18601 gcttaaggta cttgaaagtc gtagctttgt tacagaagcg atttaaatag aaaaataaga
    18661 tatagcagac tgaatttaga acagtacaca ggaat
//
LOCUS       DAVHIZ010000038        18390 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.040, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000038 DAVHIZ010000000
VERSION     DAVHIZ010000038.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 18390)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 18390)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..18390
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.040"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            68..5371
                     /locus_tag="VVO18_001451"
     CDS             68..5371
                     /locus_tag="VVO18_001451"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001032503.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEU5586585.1"
                     /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSG
                     STANLPADLATALATAKENDGRDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAE
                     EKPKEDKPAAAKPETPKTVTPEWQTVEKKEQKGTVTIREEKGVRYNQLSSTAQNDNAG
                     KPALFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTNNNVFVGYDKDGWF
                     WEYKSPTTSTWYRGSRVAAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVN
                     DHLKNEKKILLKAGSYGNDRTVVSVKTDNQEGVKADDTPAQKETGSVVDDSKVTYDTI
                     QSKVLKAVIDQAFPRVKEYTLNGHTLPGQVQQFNQVFINNHRITPEVTYKKINETTAE
                     YLMKIRDDAHLINAEMTVRLQVVDNQLHFDVTKIVNHNQVTPGQKIDDERKLLSSISF
                     LGNALVSVSSDQTGAKFDGATMSNNTHVSGDDHIDVTNPMKDLAKGYMYGFVSTDKLA
                     AGVWSNSQNSYGGGSNDWTRLTAYKETVGNANYVGIHSSEWQWEKAYKGIVFPEYTKE
                     LPRAKVVITEDANADKKVDWQDGAIAYRSIMNNPKGWEKVKDITAYRIAMNFGSQAQN
                     PFLMTLDGIKKINLHTDGLGQGVLLKGYGSEGHDSGHLNYADIGKRIGGVEDFKTLIE
                     KAKKYGAHLGIHVNASETYPESKYFNEKILRKNPDGSYSYGWNWLDQGINIDAAYDLA
                     HGRLARWEDLKKKLGDGLDFIYVDVWGNGQSGDNGAWATHVLAKEINKQGWRFAIEWG
                     HGGEYDSTFHHWAADLTYGGYTNKGINSAITRFIRNHQKDAWVGDYRSYGGAANYPLL
                     GGYSMKDFEGWQGRSDYNGYVTNLFAHDVMTKYFQHFTVSKWENGTPVTMTDNGSTYK
                     WTPEMRVELVDADNNKVVVTRKSNDVNSPQYRERTVTLNGRVIQDGSAYLTPWNWDAN
                     GKKLPTDKEKMYYFNTQTGATTWTLPSDWAESKVYLYKLTDQGKTEEQELTVKDGKIT
                     LDLLANQPYVLYRSKQTNPEMSWSEGMHIYDQGFNSGTLKHWTISGDASKAEIVKSQG
                     ANDMLRIQGNKEKVSLTQKLTGLKPNTKYAVYVGVDNRSNAKASITVNTGEKEVTTYT
                     NKSLALNYVKAYAHNTRRDNATVDDTSYFQNMYAFFTTGSDVSNVTLTLSREAGDQAT
                     YFDEIRTFENNSSMYGDKHDTGKGTFKQDFENVAQGIFPFVVGGVEGVEDNRTHLSEK
                     HDPYTQRGWNGKKVDDVIEGNWSLKTNGLVSRRNLVYQTIPQNFRFEAGKTYRVTFEY
                     EAGSDNTYAFVVGKGEFQSGRRGTQASNLEMHELPNTWTDSKKAKKATFLVTGAETGD
                     TWVGIYSTGNASNTRGDSGGNANFRGYNDFMMDNLQIEEITLTGKMLTENALKNYLPT
                     VAMTNYTKESMDALKEAVFNLSQADDDISVEEARAEIAKIEALKNALVQKKTALVADD
                     FESLDAPAQPGEGLENAFDGNLSSLWHTSWGGGDVGKPATMVLKEPTEITGLRYVPRG
                     SGSNGNLRDVKLVVTDESGKEHTFTTTDWPDNNKSKDIDFGKTIKAKKIVLTGTKTYG
                     DGGDKYQSAAELIFTRPQVAETPLDLSGYEAALAKAQKLTDKDNQEEVASVQASMKYA
                     TDNHLLTERMVEYFADYLNQLKDSATKPDAPTVEKPEFKLSSLASDQGKTPDYKQEID
                     RPETPEQILPATGESQSDTALFLAGVSLALSALFVVKTKKD"
     gene            complement(5537..7696)
                     /locus_tag="VVO18_001452"
     CDS             complement(5537..7696)
                     /locus_tag="VVO18_001452"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001040003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PBP1A family penicillin-binding protein"
                     /protein_id="HEU5586586.1"
                     /translation="MNKQTILRIAKYVSICFLTLFITAVMLGGGIFLYYVSKAPALSE
                     SKLVATTSSKIFDSKNELIADLGSERRVNAQANEIPTDLVKAIVSIEDHRFFDHRGVD
                     TIRIIGAFLRNLQNNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAVQLEQK
                     ATKQEILTYYVNKVYMSNGNYGMQTAAQNYYGKDLRELSLPQLALLAGMPQAPNQYDP
                     YSHPEAALDRRNLVLSEMKGQGYISAEQYEKAINTPITDGLQSLKSVNSYPAYMDNYL
                     KEVIDQVEQETGYNLLTTGMDVYTNVDQEAQKHLWDIYNSDQYVSYPDDDLQVASTVV
                     DVSNGKVIAQLGARHQASNVSFGTNQAVETNRDWGSSMKPITDYAPALEYGVYDSTAS
                     IVHDVPYNYPGTDTPLYNWDHVYFGNITIQYALQQSRNVTAVETLNKVGLDRAKTFLN
                     GLGIDYPSMHYANAISSNTTESNKKYGASSEKMAAAYAAFANGGIYHKPMYINKIVFS
                     DGSEKEFSDAGTRAMKETTAYMMTEMMKTVLTYGTGRGAYLPWLPQAGKTGTSNYTDE
                     EIEKYIKNTGYVAPDEMFVGYTRKYSMAVWTGYSNRLTPIVGDGFLVAAKVYRSMMTY
                     LSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPAPQQPPSTESSSSSSDSSTSQSS
                     STTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP"
     gene            complement(7693..8289)
                     /gene="recU"
                     /locus_tag="VVO18_001453"
     CDS             complement(7693..8289)
                     /gene="recU"
                     /locus_tag="VVO18_001453"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248773.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Holliday junction resolvase RecU"
                     /protein_id="HEU5586587.1"
                     /translation="MVNYPHKLSSQKRQPSLSQPKNFANRGMSFEKMINATNDYYLSQ
                     GLAVIHKKPTPIQIVRVDYPQRSRAKIVEAYFRQASTTDYSGVYNGYYIDFEAKETKQ
                     KRAIPMKNFHPHQIQHMEQILAQQGICFVLLHFSSQQETYLLPAYDLIRFYHQDKGQK
                     SMPLGYIREYGYEIKAGAFPQIPYLNVIKEHLLGGKTR"
     gene            8356..8883
                     /locus_tag="VVO18_001454"
     CDS             8356..8883
                     /locus_tag="VVO18_001454"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179549.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1273 domain-containing protein"
                     /protein_id="HEU5586588.1"
                     /translation="MATALVLGYSAFDLGLFSDKDPRLKLIKKAIRKDLEAMAADGVS
                     WLVFTGTLGFEYWVLEVAQEMKTEYGFQLATIFAFETHGENWNEGNQMKLSRFKQVDF
                     VKYAYPRYEHKGQLRDYQQFLLENTTSSYLFYDEENETKLAYFYQKMKNQEDYFIKRL
                     TFDQLNELAENFSEN"
     gene            8953..9294
                     /gene="gpsB"
                     /locus_tag="VVO18_001455"
     CDS             8953..9294
                     /gene="gpsB"
                     /locus_tag="VVO18_001455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000200645.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division regulator GpsB"
                     /protein_id="HEU5586589.1"
                     /translation="MTSIIFSAKDIFEQEFGREVRGYSKVEVDEFLDDVIKDYETYAA
                     LVKSLRQEIADLKEELTRKPQVSSAPSPSHPDPIDVAASSSMTNFDILKRLNRLEKEV
                     FGKQILDNTDL"
     gene            9315..9695
                     /gene="rnpB"
                     /locus_tag="VVO18_001456"
     ncRNA           9315..9695
                     /ncRNA_class="RNase_P_RNA"
                     /gene="rnpB"
                     /locus_tag="VVO18_001456"
                     /product="RNase P RNA component class B"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00011"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00011"
     gene            9780..10937
                     /locus_tag="VVO18_001457"
     CDS             9780..10937
                     /locus_tag="VVO18_001457"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000711388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent RNA methyltransferase"
                     /protein_id="HEU5586590.1"
                     /translation="MKKEFNLIATVAAGLEAVVGREVRELGYDCQVENGRVRFQGDVR
                     AIIETNLWLRAADRIKIIVGTFPAKTFEELFQGVFALDWENYLPLGARFPISKAKCVK
                     SKLHNEPSVQAISKKAVVKKLQKHYARPEGVPLMENGPEFKIEVSILKDVATVMIDTT
                     GSSLFKRGYRTEKGGAPIKENMAAAILQLSNWYPDKPLIDPTCGSGTFCIEAVMIARK
                     MAPGLRRSFAFEEWNWVSDRLIQEVRTEAAKKVDRELELDIMGCDIDARMVEIAKANA
                     QAAGVAGDITFKQMRVQDLRSDKINGVIISNPPYGERLSDDAGVTKLYSEMGQVFAPL
                     KTWSKFILTSDEAFESKYGSQADKKRKLYNGTLKVDLYQYFGQRVKRQEVK"
     gene            10950..12344
                     /gene="mapZ"
                     /locus_tag="VVO18_001458"
     CDS             10950..12344
                     /gene="mapZ"
                     /locus_tag="VVO18_001458"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000039255.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mid-cell-anchored protein MapZ"
                     /protein_id="HEU5586591.1"
                     /translation="MSKKRRNRHKKEGQEPQFDFDEAKELTVGQAIRKNEEVEAGVLS
                     EDSILDKYVKQHRDEIEADKFATRQYKKEELVETQSLDDLIQEMREAVEESEAYSEEV
                     PSSEDILPPLPLDDEEQGLDPLLLEDENPTEMTEEVEEEQNLSRLEQEESEKKSKKGF
                     VLTALALVSVIICVSAYYVYRQVNRSTKEIETSQSTTANQSDVDDFNTLYDAFYTDSN
                     KTALKNSQFDKLSQLKTLLDKLEGSREHTLAKSKYDSLATQIKAIQDVNAQFEKPAIV
                     DGVLDTNAKAKSDAKFTDIKTGNTELDKVLDKAISLGKSQQTSTSSSSSSETSSSSTS
                     QTSSNTTSETSPSSSNETRSSRSEVNMGLSSAGVAVQRSASRVAYNQSAIDDSNNSAW
                     DFADGVLEQILATSRSRGYITGDQYILERVNIVNGNGYYNLYKPDGTYLFTLNCKTGY
                     FVGNGAGHADDLDY"
     gene            12420..13844
                     /gene="gndA"
                     /locus_tag="VVO18_001459"
     CDS             12420..13844
                     /gene="gndA"
                     /locus_tag="VVO18_001459"
                     /EC_number="1.1.1.44"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004185725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /protein_id="HEU5586592.1"
                     /translation="MTKANFGVVGMAVMGRNLALNIESRGYTVAIYNRSKEKTEDVIA
                     CHPEKNFVPSYDVESFVNSIEKPRRIMLMVQAGPGTDATIQALLPHLDKGDILIDGGN
                     TFYKDTIRRNEELANSGINFIGTGVSGGEKGALEGPSIMPGGQKEAYELVADVLEEVS
                     AKAPEDGKPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAESYDLMQHLLGLSAEDMAE
                     IFTEWNKGELDSYLIEITADILSRKDDEGQDGPIVDYILDAAGNKGTGKWTSQSSLDL
                     GVPLSLITESVFARYISTYKEERVHASKVLPKPAAFNFEGDKAELIEKIRQALYFSKI
                     ISYAQGFAQLRVASKENNWNLPFADIASIWRDGCIIRSRFLQKITDAYNRDADLANLL
                     LDEYFLDVTAKYQQAVRDIVALAVQAGVPVPTFSAAITYFDSYRSADLPANLIQAQRD
                     YFGAHTYQRKDKEGTFHYSWYDEK"
     gene            13856..14545
                     /locus_tag="VVO18_001460"
     CDS             13856..14545
                     /locus_tag="VVO18_001460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000518023.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586593.1"
                     /translation="MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQ
                     TDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMILDHWEDLQEELEVVQRFAVSYIY
                     KPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
                     REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIK
                     TVRGVGYTMQE"
     gene            14643..15605
                     /gene="cbpC"
                     /locus_tag="VVO18_001461"
     CDS             14643..15605
                     /gene="cbpC"
                     /locus_tag="VVO18_001461"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000771084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpC"
                     /protein_id="HEU5586594.1"
                     /translation="MKILKKMMQVLLAVFFFGLLATNTVFANTTGGRFVDKDNRKYYV
                     KDDHKAIYWHKIDGKTYYFGDGGEMVVGWQYLEIPGTGYRDNLFDNQPVNEIGLQEKW
                     YYFGQDGALLEQTDKQVLEAKTSENTGKVYGEQYPLSAEKRTYYFDNNYVVKTGWIYE
                     DGNWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKML
                     TDWQKVNGKWYYFGSSGSMATGWKYVRGKWYYLDNKNGDMKTGWYQDGSTWYYLDPSN
                     GDMKIGWTKVNGKWYYLNSNGAMVTGSQTIDGKVYNFASSGEWI"
     gene            15624..16622
                     /gene="cbpJ"
                     /locus_tag="VVO18_001462"
     CDS             15624..16622
                     /gene="cbpJ"
                     /locus_tag="VVO18_001462"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698047.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline-binding protein CbpJ"
                     /protein_id="HEU5586595.1"
                     /translation="MKLLKKTMQAGLTVIFFGLLATNTVFADNSEGWQFVQENGRTYY
                     KKGDLKETYWLVIDGKYYYFDSLSGEMVVGWQYIPFPSKGSTIGPYPNGIRLEGFPKS
                     EWYYFDKNGVLQEFVGWKTLEIKTKDSVGRKYGEKREDSEDKEEKRYYTNYYFNQNHS
                     LETGWLYDQSNWYYLAKTEINGENYLGGERRAGWINDDSTWYYLDPTTGIMQTGWQYL
                     GNKWYYLRSSGAMATGWYQEGTTWYYLDQPNGDMKTGWQNLGNKWYYLRSSGAMATGW
                     YQDGSTWYYLNAGNGDMKTGWFQVNGNWYYAYSSGALAVNTTVDGYSVNYNGEWVR"
     gene            complement(16740..17972)
                     /locus_tag="VVO18_001463"
     CDS             complement(16740..17972)
                     /locus_tag="VVO18_001463"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765682.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU5586596.1"
                     /translation="MKLFWTNNIYRQLLLNSCFSSFGDSIFYLAIINYVAQYNFAPLA
                     ILLISISEMVPLLSQLFLGILGDFQENRVKHALCIAKIKILLYAILTVFLVLSPFSLV
                     SVIMIVIINLISDTLSYLSAYMMNALYISVIKDNLHDAMGFRQSLMRVVRIVANLAGV
                     FLINVMSIQTISLINTLTFVIAFLGLYVIRHTLYEVEKKIEMSHTALSFKKYFQHLKQ
                     SLAVLLRLKDTVILLFLTTSMIAILDVSPRLIALRFIQQTLAQLSIGQLLALLSIIIS
                     CGAILGNMTSSNLFKNIRFTHLLVFCEISLLALITSILCQTYIVIFMTSFISSTIIGI
                     LSPRLQAAVFAHIPSDKMGTVGSALSTVDILAPSLLSLLALSIASGVSVQLALIFLYL
                     ILIALIFCQWLVTFNTHN"
     gene            complement(18015..>18390)
                     /locus_tag="VVO18_001464"
     CDS             complement(18015..>18390)
                     /locus_tag="VVO18_001464"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001817814.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="lanthionine synthetase"
                     /protein_id="HEU5586597.1"
                     /translation="LLEKVTSNTENLGNLQLSWCKGISGIILYLCMYDCDGNKDIISK
                     YQEFVFNHHLKMMTGYCHGITSLLQTTVYNQNKLLMKKIQQVILACSERDDHGLLMFQ
                     GDSGKADLFDFGIGSMGYIGVY"
BASE COUNT         5717 a         3325 c         4214 g         5134 t
ORIGIN      
        1 gaggaaggag tattttttaa aaaggaaatg taaacgcttg ctaaaaaatg aaaggattta
       61 gaagtttatg aataaaggat tatttgaaaa acgttgtaaa tatagtattc ggaaattttc
      121 attaggtgtt gcttctgtta tgattggagc tgcattcttt gggacaagtc cggttcttgc
      181 agatagcgtg cagtctggtt ccacggcgaa cttaccagct gatttagcta ctgctcttgc
      241 aacagcaaaa gagaatgatg gacgtgattt tgaagcgcct aaggtgggag aagaccaagg
      301 ttctccagaa gttacagatg gacctaagac agaagaagaa ctattagcac ttgaaaaaga
      361 aaaaccggct gaagaaaaac caaaagagga taaacctgca gctgctaaac ctgaaacacc
      421 taagacggta acccctgaat ggcaaacggt agagaaaaaa gaacaaaagg gaacagtcac
      481 tatccgagaa gaaaaaggtg tccgctacaa ccaactatcc tcaactgctc aaaatgataa
      541 cgcaggtaaa ccagccctgt ttgaaaagaa gggcttgacc gttgatgcca atggaaatgc
      601 aactgttgat ttaaccttca aagatgattc tgaaaagggc aaatcacgct ttggtgtctt
      661 cctgaaattt aaagatacca ataataatgt ttttgtcggt tatgacaagg atggctggtt
      721 ctgggagtat aaatctccaa caactagcac ttggtataga ggtagtcgtg ttgctgctcc
      781 tgaaacagga tcaacaaacc gtctctctat cactctcaag tcagacggtc agctaaatgc
      841 cagcaataac gatgtcaatc tctttgacac agtgactcta ccagctgcgg tcaatgacca
      901 tcttaaaaat gagaagaaga tccttctcaa ggcgggctct tatggcaatg accgtacggt
      961 tgtcagcgtt aaaacagaca atcaagaagg cgtaaaagcg gatgatactc ctgcccagaa
     1021 agaaacaggt tcggttgttg acgatagcaa ggtgacttat gatacgatcc agtctaaggt
     1081 acttaaggca gtaattgacc aagccttccc tcgtgtcaag gaatacacct tgaatggaca
     1141 tactttgcca ggacaggtgc aacagttcaa ccaagtcttt atcaataacc accgaatcac
     1201 ccctgaagtc acttataaga aaatcaatga gacaacagca gagtacttga tgaagattcg
     1261 cgatgatgct cacttaatca atgcggaaat gacagtacgc ttgcaagttg tggacaatca
     1321 attgcacttt gatgtgacca agattgtcaa ccacaatcaa gtcactccag gtcaaaagat
     1381 tgatgacgaa agaaaactac tttcttctat tagtttcctc ggcaatgctt tagtctctgt
     1441 ttctagtgat caaactggtg ctaagtttga tggggcaacc atgtcaaaca atacgcatgt
     1501 cagcggagat gatcatatcg atgtaaccaa tccaatgaag gatttggcta agggttacat
     1561 gtatggattt gtttctacag ataagcttgc tgctggtgtt tggagtaact ctcaaaacag
     1621 ctatggtggt ggttcgaatg actggactcg tttgacagct tataaagaaa cagtcgggaa
     1681 tgccaactat gtaggaatcc acagctctga atggcaatgg gaaaaagctt ataagggcat
     1741 tgttttccca gaatacacga aggaacttcc aagggctaag gttgttatca ctgaagatgc
     1801 caatgcagac aagaaagtcg attggcagga tggtgccatt gcttatcgta gcattatgaa
     1861 caaccctaaa ggttgggaaa aagttaagga tatcacagct taccgtatcg cgatgaactt
     1921 tggttctcaa gcacaaaacc cattccttat gaccttggat ggtatcaaga aaatcaatct
     1981 ccacacagat ggtcttgggc aaggtgttct ccttaaagga tatggtagtg aaggtcacga
     2041 ctctggtcac ttgaactatg ctgatattgg taagcgtatc ggtggtgtcg aagacttcaa
     2101 gaccctaatt gagaaggcta agaaatatgg agctcatcta ggtatccacg ttaacgcttc
     2161 agaaacttat cctgagtcta aatacttcaa tgaaaaaatt ctccgtaaga atccagatgg
     2221 aagctatagc tatggttgga actggctaga tcaaggtatc aacattgatg ctgcctatga
     2281 cctagctcat ggtcgtttgg cacgttggga agatttgaag aaaaaacttg gtgacggtct
     2341 cgactttatc tatgtggacg tttggggtaa tggtcaatca ggtgataacg gtgcctgggc
     2401 tacccacgtt cttgctaaag aaattaacaa acaaggctgg cgctttgcga tcgagtgggg
     2461 ccatggtggt gagtacgact ctaccttcca tcactgggca gctgacttga cctacggtgg
     2521 ctacaccaat aaaggtatca acagtgccat cacccgcttt atccgtaacc accaaaaaga
     2581 tgcttgggta ggggactaca gaagttatgg tggtgcagcc aactatccac tgctaggtgg
     2641 ctacagcatg aaagactttg aaggctggca aggaagaagt gactacaatg gctatgtaac
     2701 caacttattt gcccatgacg tcatgactaa gtacttccaa cacttcactg taagtaaatg
     2761 ggaaaatggt acaccggtga ctatgaccga taacggtagc acctataaat ggactccaga
     2821 aatgcgagtg gaattggtag atgctgacaa taataaagta gttgtaactc gtaagtcaaa
     2881 tgatgtcaat agcccacaat atcgcgaacg tacagtaacg ctcaacggac gtgtcatcca
     2941 agatggttca gcttacttga ctccttggaa ctgggatgcg aatggtaaga aacttcctac
     3001 tgataaggaa aagatgtact acttcaatac gcagactggt gcaacaactt ggacccttcc
     3061 aagcgattgg gcagagagca aggtttacct ttacaagcta actgaccaag gtaagacaga
     3121 agagcaggaa ctaactgtaa aagatggtaa aattacccta gatcttctag caaatcaacc
     3181 atacgttctc tatcgttcga aacaaaccaa tcctgaaatg tcatggagtg aaggcatgca
     3241 catctatgac caaggattta atagcggtac cttgaaacat tggaccattt caggcgatgc
     3301 ttctaaggca gaaattgtca agtctcaagg ggcaaacgat atgcttcgta ttcaaggaaa
     3361 caaagaaaaa gttagtctca ctcagaaatt aactggcttg aaaccaaata ccaagtatgc
     3421 cgtttatgtc ggtgtcgata accgtagtaa tgccaaggca agtatcactg tgaatactgg
     3481 tgaaaaagaa gtgactactt ataccaataa gtctctcgcg ctcaactatg ttaaggccta
     3541 cgcccacaat acacgtcgtg ataatgctac agttgatgat acaagttact tccaaaacat
     3601 gtacgccttc tttacaactg gatcggacgt ctcaaatgtt actctgacat tgagtcgtga
     3661 agctggtgat caagcaactt actttgatga aattcgtacc tttgaaaaca attcaagcat
     3721 gtacggagac aagcatgata caggtaaagg caccttcaag caagactttg aaaatgttgc
     3781 tcagggtatc ttcccatttg tagtgggtgg tgtcgaaggt gttgaagata accgcactca
     3841 cttgtctgaa aaacacgatc catatacaca acgtggttgg aatggtaaga aagtcgatga
     3901 tgttatcgaa ggaaattggt cactcaagac aaatggacta gtgagccgtc gtaacttggt
     3961 ttaccaaact attccgcaaa acttccgttt tgaagcaggt aagacctacc gtgtaacctt
     4021 tgaatacgaa gcaggttcag acaataccta tgcttttgta gtcggtaagg gagaattcca
     4081 gtcaggtcgt cgtggcactc aagcaagcaa cttggaaatg catgaattgc caaatacttg
     4141 gacagattct aagaaagcca agaaggcaac cttccttgtg acaggtgcag aaacaggaga
     4201 tacttgggta ggtatctact caactggaaa tgcaagtaat actcgtggtg attctggtgg
     4261 aaatgccaac ttccgtggtt ataacgactt catgatggat aatcttcaaa tcgaagaaat
     4321 taccctaaca ggtaagatgt tgacagaaaa tgctctgaag aactacttgc caacggttgc
     4381 catgactaac tacaccaaag agtctatgga tgctttgaaa gaggcggtct ttaacctcag
     4441 tcaggccgat gatgatatca gtgtggaaga agcgcgtgca gagattgcca agattgaagc
     4501 cttgaagaat gctttggttc agaagaaaac ggctttggta gcagatgact ttgaaagttt
     4561 ggatgcgcca gctcaaccag gtgaaggtct tgagaatgcc tttgatggaa acttatctag
     4621 tttatggcat acatcatggg gcggaggaga tgtaggcaag cctgcaacca tggtcttgaa
     4681 agaaccaact gaaatcactg gacttcgtta tgttccacgt ggatcaggtt caaatggtaa
     4741 cttgcgtgat gtgaaacttg ttgtgacaga tgagtctggc aaggagcata cctttactac
     4801 aactgattgg ccagataaca ataagtcaaa agatattgac tttggtaaga caatcaaggc
     4861 taagaaaatt gtccttactg gtaccaagac atacggagat ggtggagata aataccaatc
     4921 tgcagcggaa cttatcttta ctcgtccaca ggtagcagaa acacctcttg acttgtcagg
     4981 ctatgaagca gctttggcta aggctcagaa attaacagac aaagacaatc aagaggaagt
     5041 agctagcgtt caggcaagca tgaaatatgc gacggataac catctcttga cggaaagaat
     5101 ggtggaatac tttgcagatt atctcaacca attaaaagat tctgctacga aaccagatgc
     5161 tccaactgta gagaaacctg agtttaaact tagctcttta gcttccgatc aaggtaagac
     5221 gccagattat aagcaagaaa tagatagacc agaaacacct gaacaaatct tgccagcaac
     5281 aggtgagagt caatctgaca cagccctctt cctagcaggt gttagcctag ccctatctgc
     5341 tctctttgta gtaaaaacga agaaagacta gtatttagta aaacctctta acaagattac
     5401 ggaagcagtc tctatctttt ccaatgaggt ttatagtaca gaaaaaatct gagaagatgt
     5461 cttctcagac ttttgttaag cacataaata caatagtgct atgacaaaat cacccagaaa
     5521 atctgggtga taaatgttat ggttgtgctg gttgaggatt ctgattttgt tgatcagggg
     5581 ttgtatttga ttgttgcgta ttattgttag gattggtagt cgtactatta tttgtgcttg
     5641 gagtggttga gctagactgt gaagttgaac tatctgatga tgagcttgaa ctttcagttg
     5701 atgggggttg ttgtggagca ggtgagctcc acgtagaacg agcaccattt ttaaatacga
     5761 attctccatt tctgtagagc ccctctggta tattccaatc ctctggattg cttccttcag
     5821 acaggtaggt catcatagag cgataaactt tagctgcaac taggaaacca tctccaacga
     5881 taggagttaa acgattcgaa taacctgtcc atacagccat agaatactta cgagtataac
     5941 ccacaaacat ttcatctgga gctacgtagc cagtgttctt gatatacttt tcaatttctt
     6001 cgtcagtata gttagaagta cctgtcttac ctgcttgtgg aagccatggt aggtaggctc
     6061 cacgtcctgt tccgtaagtt aaaacagttt tcatcatttc agtcatcata taggcagtag
     6121 tctctttcat agctcgtgta ccagcatcag aaaattcttt ttcgctacca tcactaaaga
     6181 cgattttatt gatatacatt ggtttgtgat aaataccacc attagcaaaa gcagcgtagg
     6241 cagcagccat tttttcacta cttgcaccat attttttgtt ggattcagtt gtgttacttg
     6301 aaatggcgtt tgcataatgc atgcttggat agtcgatacc aagaccatta aggaaggttt
     6361 tagctctatc tagaccgacc ttattcaaag tctcaacggc tgtgacattt cgtgattgtt
     6421 gaagagcata ctggattgta atgtttccaa agtagacatg atcccagttg tagagtggag
     6481 tatcagtgcc aggatagtta taagggacat catgtacaat agaagcagta gagtcataga
     6541 ctccatattc taaagcggga gcatagtcag tgattggttt cattgatgat ccccagtcac
     6601 gattggtttc tacggcctgg ttggtaccga atgaaacatt acttgcttga tgacgagcac
     6661 caagttgtgc gatgacttta ccatttgaaa catctacgac cgtagatgcg acttgcaaat
     6721 catcgtcagg gtaagagacg tattgatcgg agttgtagat atcccacaga tgtttttgag
     6781 cttcttggtc tacatttgtg taaacatcca tcccagtagt tagaaggtta tagccagttt
     6841 cttgttctac ttggtcgata acctctttga gataattgtc catatatgct ggatagctat
     6901 tgaccgattt caaactttgg agtccatcag taataggggt attaatagcc ttctcatact
     6961 gttcggcaga aatgtagcct tgacctttca tctctgaaag taccaagtta cgacggtcaa
     7021 gggcagcttc tggatgagaa tagggatcgt attgattcgg agcctgtggc attcctgcta
     7081 gtagggcaag ttgaggtaat gatagttctc gcaaatcttt gccgtaatag ttttgggcag
     7141 ccgtctgcat tccatagttt ccgttagaca tgtaaacttt attcacatag taggtcagga
     7201 tttcttgttt tgtggctttt tgttctaatt gaacagccaa ccaagcttcc tgggctttac
     7261 gtgaaatggt ctgatcagaa gtggaagttg agaaataggt caacttaatt aattgttggg
     7321 taagggtaga tcctccctgg agggagttgt tttgtaagtt acgtaaaaaa gctcctataa
     7381 ttcggatggt atcgacaccg cgatgatcga aaaaacgatg gtcttcgatc gatacgatag
     7441 ccttgaccaa atcagtagga atttcgttgg cctgagcgtt tactcggcgt tcagagccca
     7501 gatcggcaat cagttcgttt ttactatcga aaatcttact agacgtggtt gcgactaatt
     7561 tgctctcaga tagggctggg gctttgctga cgtaatagag aaatatgcct cctcccagca
     7621 taactgctgt gataaataaa gttaagaagc agatactcac atacttagct attcgcagga
     7681 tagtttgttt gttcatcttg ttttaccacc taataaatgt tctttgataa cattgagata
     7741 gggaatttga gggaaggcac cagccttgat ttcatatcca tattctcgaa tatatccaag
     7801 tggcattgat ttttgcccct tatcttgatg atagaagcga atcaaatcat atgccggtaa
     7861 taagtaggtt tcttgctgag aagaaaagtg aagaaggaca aagcagattc cttgttgagc
     7921 aaggatttgt tccatatgct gaatctgatg tggatggaaa tttttcatcg gaatcgcacg
     7981 tttttgtttt gtttccttgg cttcaaagtc gatgtaatat ccattataaa cgccagaata
     8041 gtccgtcgtt gaagcttgtc gaaaataggc ttcaacaatc ttggcacgac ttcgttgtgg
     8101 atagtccact cgtacgattt gaataggagt tggtttcttg tgtataacag ccaagccctg
     8161 agacaaatag tagtcgttgg tagcattgat catcttttca aaagacattc ctcgatttgc
     8221 gaaatttttg ggttgagaaa gagatggttg tcttttttgt gatgaaagtt tatgtggata
     8281 gttgaccata attctcctta ttggtacaat aacatcactc tattatacca taaatttgca
     8341 cagaaagggt taaaaatggc tacagctttg gttttgggct attctgcttt tgatttgggt
     8401 ttattttctg ataaggatcc tcgtcttaaa ttgataaaaa aagcaatacg taaagattta
     8461 gaggctatgg cagcagatgg ggtgtcttgg cttgtgttta cagggacttt gggctttgaa
     8521 tattgggttt tagaggttgc tcaggagatg aaaaccgagt acggtttcca gttggccacc
     8581 atttttgctt ttgaaaccca tggggaaaat tggaatgaag gcaatcagat gaaactgagt
     8641 cgttttaagc aggtagactt tgtcaaatat gcttatcctc gctatgagca caaggggcag
     8701 ttaagagatt accagcagtt tttgctggaa aacacgacta gttcctatct tttttatgat
     8761 gaagaaaatg aaacgaaact agcttatttt taccaaaaga tgaaaaatca agaggactat
     8821 tttataaaga gattaacatt tgatcaatta aatgaacttg ctgaaaattt ttccgaaaat
     8881 tgaagctttg accttgattt ttgtttgcct ttttttatat aataatacta gcaagcgaga
     8941 atggagagag acatgacaag tattattttt tcagcaaaag atatttttga acaagagttt
     9001 ggacgtgaag ttcgtgggta tagcaaggta gaagttgatg agtttttaga cgatgtcatc
     9061 aaggactatg aaacctatgc tgccttggtt aagtcacttc gtcaggagat tgcggatttg
     9121 aaggaagaat taactcgtaa accgcaagtg agttcggctc caagtcctag tcacccagat
     9181 ccaattgatg tggctgcttc atcttctatg acgaattttg atattttgaa acgcttgaat
     9241 cgtcttgaaa aagaagtatt cggtaaacaa attttagaca atactgattt gtaattcagg
     9301 tcttgttaca tgcaattttt ggataatcgc gtgaggagaa ttgcttctca tgaggaaagt
     9361 ccatgctagc acaggctgtg atgcctgtag tgtttgtgct aggcgaaacc ataagcctag
     9421 ggacgagaaa tcgttacggc agttgaaatg gctaagtcct tggataggcc agagtaggct
     9481 tgaaagtgcc acagtgacgg agtctttctg gaaacagaga gagtggaacg cggtaaaccc
     9541 ctcaagctag caacccaaat tttggtcggg gcatggagta cgcggaaacg aacgtagtat
     9601 tctgactgct atcagctaga gctgctagtg gtagacagat gattatcgaa ggaagtggtc
     9661 ctagtcattt ctggaacaaa acatggctta tagaaaattg catataggtt ggggctgaga
     9721 aattttctca acctcatttt ttaaagtgga catatagaaa ggtcttgcaa gactgtaaca
     9781 tgaaaaaaga atttaattta attgcaactg tggcagcagg tcttgaagct gttgtaggac
     9841 gagaagtaag agagctgggc tacgattgtc aggttgaaaa tgggcgtgtg cgttttcaag
     9901 gagacgtgag agcgattatc gaaaccaacc tctggcttcg ggcagcagat cgtatcaaga
     9961 tcatcgtagg aacgttccca gctaagacgt ttgaagagtt gtttcaggga gtttttgctt
    10021 tagattggga aaattattta ccactcggag ctcggttccc aatttcaaaa gccaaatgtg
    10081 ttaaatctaa acttcacaat gaacccagtg ttcaggctat ttctaagaaa gctgttgtca
    10141 agaaattgca gaaacactat gctcgcccag aaggggttcc tctgatggag aatggcccag
    10201 agtttaagat tgaggtctct attctcaaag atgtggcaac tgtcatgatt gatacgacag
    10261 gctctagcct ctttaaacgt ggttatcgta ccgaaaaagg gggagcccct atcaaggaaa
    10321 acatggcggc agccatttta caactttcta actggtatcc agacaagcct ttgattgatc
    10381 cgacatgtgg ttcggggact ttctgtatcg aggcggtcat gattgctcga aagatggctc
    10441 caggtcttcg tcgctccttt gcttttgagg aatggaattg ggtcagcgat cgcttgattc
    10501 aggaagtgcg tacagaagcg gctaaaaaag tagaccgtga gcttgaactg gatattatgg
    10561 gctgtgatat cgatgcacgt atggtggaaa ttgctaaggc caatgctcag gcagctggtg
    10621 ttgcaggaga cattactttt aagcagatgc gcgttcagga tttacgttct gataaaatta
    10681 atggtgtaat catttccaat ccgccttatg gtgaacgttt atcagatgat gcaggagtta
    10741 ccaagctcta ttctgagatg gggcaagtat ttgcaccact gaaaacttgg agcaaattta
    10801 tcctgactag tgatgaagcc tttgaaagca agtatggtag ccaagcagat aagaagcgta
    10861 agttatacaa cggaaccttg aaagtggatc tgtatcaata ttttggtcag cgtgtcaaac
    10921 ggcaagaggt aaaatagaaa gggatactca tgagtaaaaa aagacgaaat cgtcataaaa
    10981 aagaaggtca agaaccgcaa tttgattttg atgaagcaaa agagctaaca gttggtcaag
    11041 cgattcgtaa aaatgaagaa gtggaagcag gagtcttgtc tgaggattcc attttggaca
    11101 agtatgtcaa gcaacacaga gatgaaattg aggcggataa gtttgcgact cgtcaataca
    11161 aaaaagagga gttagtcgaa actcagagtc tggatgattt aattcaagag atgcgtgagg
    11221 ctgtagaaga gtcagaagct tattcggagg aagttccatc ttctgaagac atcttaccac
    11281 ccttgcctct ggatgatgag gagcaaggct tggatcctct attactagag gatgaaaatc
    11341 caacagaaat gactgaagaa gtggaagagg agcaaaatct ttctcgtctg gaacaagaag
    11401 agtcagaaaa gaaaagcaaa aaaggctttg ttttaaccgc tttggcgctt gtatcagtga
    11461 ttatctgtgt cagtgcttat tatgtctatc gtcaagtgaa tcgctcgacc aaggaaattg
    11521 aaacttctca atcaactaca gccaatcaat cggatgtgga tgattttaat acactttatg
    11581 acgccttcta cacagacagt aataaaacgg ctttgaaaaa tagccagttt gataaactaa
    11641 gtcaactcaa gaccttactt gataagctgg aaggtagtcg tgaacatacg cttgccaaat
    11701 ctaaatatga tagtctagca acgcaaatca aggccattca agatgtcaat gcacaatttg
    11761 aaaaaccagc tattgtggat ggtgtgttgg ataccaatgc caaagccaaa tcggatgcta
    11821 aatttacaga tattaaaact ggaaatacgg agcttgataa agtgctagat aaggctatca
    11881 gccttggtaa gagccagcaa acaagtactt ctagctcaag ttcaagtgaa actagtagct
    11941 caagcactag tcaaacaagc tcaaatacga ctagtgagac aagcccaagt agttcaaatg
    12001 agactagaag tagtcgcagt gaagtcaata tgggtctctc gagtgcaggg gttgctgttc
    12061 aaagaagtgc cagtcgtgtt gcctataatc agtctgctat tgatgatagt aacaactctg
    12121 cctgggattt tgcggatggt gtcttggaac aaattctagc tacttcacgt tcacgtggct
    12181 atatcactgg agaccaatat atccttgaac gtgtcaatat cgttaatggc aatggttatt
    12241 acaacctcta caagccagat ggaacctatc tctttaccct taactgtaag acaggctact
    12301 ttgtcggaaa tggcgctggt cacgcggatg acttggacta ctaagcagtc gttacaaaat
    12361 tctttctttt caaaagtaaa aatgataaaa taaaacaaat gaaacaagag gagtgtcaaa
    12421 tgacaaaagc taactttggt gtcgtaggta tggccgtaat gggtcgtaac cttgccctta
    12481 atattgaatc tcgtggttac acagttgcta tttacaaccg tagtaaagaa aaaactgaag
    12541 atgtaattgc ttgccatcct gaaaagaact ttgtaccaag ctatgacgtt gaaagttttg
    12601 taaactcaat cgaaaaacct cgtcgtatca tgctgatggt tcaagctgga cctggtacag
    12661 atgctactat ccaagccctt cttccgcacc ttgacaaggg tgatatcttg attgacggtg
    12721 gaaatacttt ctacaaagat accatccgtc gtaatgaaga attggcaaac tcaggtatca
    12781 actttatcgg tactggagtt tctggtggtg aaaaaggtgc ccttgaaggt ccttctatca
    12841 tgcctggtgg acaaaaagag gcctacgaat tggttgcgga tgttcttgaa gaagtctcag
    12901 ctaaagcacc agaagatggc aaaccatgtg tgacttacat cggccctgat ggagctggtc
    12961 actatgtgaa aatggttcac aatggtattg agtacggtga tatgcaattg atcgcagaaa
    13021 gctatgactt gatgcaacac ttgctaggcc tttctgcaga ggatatggct gaaatcttta
    13081 ctgagtggaa caagggtgaa ttagacagct atttgatcga aatcacagct gatatcttga
    13141 gccgtaaaga cgatgaaggc caagatggac caatcgtaga ctacatcctt gatgctgcag
    13201 gtaacaaggg aactggtaaa tggactagcc aatcatctct tgaccttggt gtaccattgt
    13261 cactgattac tgagtcagtg tttgcacgct acatttcaac ttacaaggaa gaacgtgtac
    13321 atgctagcaa ggtgcttcca aaaccagctg ccttcaactt tgaaggagac aaggctgaat
    13381 tgattgaaaa aatccgtcaa gccctttact tctcaaaaat catttcatac gcacaaggat
    13441 ttgctcaatt gcgtgtagcc tctaaagaaa acaactggaa cttgccattt gcagatatcg
    13501 catctatctg gcgtgatggc tgtatcatcc gttctcgttt cttgcaaaag attacagatg
    13561 cttacaaccg tgatgcagac cttgccaacc ttcttttgga tgaatacttc ttggatgtta
    13621 ctgctaagta tcaacaagca gtgcgtgata tcgtagctct tgcggttcaa gctggtgtgc
    13681 cagtgccaac tttctcagca gctattactt actttgatag ctaccgttca gctgaccttc
    13741 cagctaactt gatccaagca caacgtgact actttggtgc tcacacttac caacgtaaag
    13801 acaaagaagg aaccttccac tactcttggt atgacgaaaa ataagtaggt cagccatggg
    13861 gaaacggatt ttattacttg agaaagaacg aaatctagct cattttttaa gtttggaact
    13921 ccagaaagag cagtatcggg ttgatctggt agaggagggg caaaaagccc tctccatggc
    13981 tcttcagaca gactatgatt tgattttatt gaacgttaat ctgggagata tgatggctca
    14041 ggattttgca gaaaaattga gtcgaactaa acctgcctca gtcatcatga ttttagatca
    14101 ttgggaagac ttgcaagaag agctggaagt tgttcagcgt tttgcagttt catacatcta
    14161 taagccagtc cttatcgaaa atctggtagc gcgtatttcg gcgatcttcc gaggtcggga
    14221 cttcattgat caacactgca gtctgatgaa agttccaagg acctaccgca atcttaggat
    14281 agatgttgaa catcacacgg tttatcgtgg tgaagagatg attgctctga cccgccgtga
    14341 gtatgacctt ttggcgacac ttatgggaag caagaaagta ttgactcgtg agcaattgtt
    14401 ggaaagtgtt tggaagtatg aaagtgcgac cgagacaaat atcgtagatg tctatatccg
    14461 ctatctacgg agcaagcttg atgttaaagg ccaaaaaagc tacattaaaa ccgtgcgtgg
    14521 tgttggttac accatgcaag aatagaaaag cagttgcagt tgtgtaactg cttttttgag
    14581 gagtttttat atattgacat gcagtcgggt ctttgctaca atcgttttag gagggtatat
    14641 agatgaaaat tttgaaaaaa atgatgcaag ttctactagc agtctttttc tttggtttgc
    14701 tagctacaaa tacggtattt gcgaatacca caggtggccg atttgttgat aaggataata
    14761 gaaaatatta tgtaaaagat gatcataaag caatctattg gcataaaata gacggtaaaa
    14821 cctactattt tggtgatgga ggagagatgg ttgtcggttg gcaatactta gaaattcctg
    14881 gaacaggtta tcgtgataat ttattcgata accaaccagt taatgaaatt ggccttcagg
    14941 agaagtggta ctattttgga caagatggtg ctttgttaga acaaacagat aaacaagtac
    15001 tagaggcaaa aacgtctgaa aatacaggaa aagtatacgg tgaacaatat cctctatctg
    15061 ctgaaaagag aacttattat tttgataata attatgttgt aaagacaggc tggatttatg
    15121 aagacggcaa ttggtattat ttaaataagc taggaaattt tggcgatgat tcttacaatc
    15181 cactaccaat tggtgaagtt gctaagggtt ggactcaaga ttttcatgtt actattgaca
    15241 ttgatagaag caaacctgct ccatggtact acctagatgc ttccggtaag atgcttacag
    15301 attggcaaaa agtaaacgga aaatggtatt attttggctc ctctggttct atggcaacag
    15361 gttggaaata tgtacgaggc aaatggtatt acttagataa taaaaatggt gatatgaaga
    15421 ctggttggta tcaagatggt tcaacttggt actatttaga tccttctaat ggagatatga
    15481 aaataggttg gacaaaagta aatggaaaat ggtattatct caattcaaat ggagcaatgg
    15541 ttacaggtag tcaaactatc gatggtaaag tttataactt cgcttcatct ggtgagtgga
    15601 tttaatgttg gaggatatat aaaatgaagc ttttgaaaaa aactatgcaa gctggactaa
    15661 cagtaatttt ctttggtttg ctagctacga atacagtatt tgcagataac tctgaaggat
    15721 ggcagtttgt ccaagaaaac ggtagaacct attacaaaaa gggggacctc aaagaaacct
    15781 actggctagt gattgatggt aagtactatt attttgattc tctatctgga gagatggttg
    15841 tcggctggca atatatcccg tttccatcta aaggtagtac aattggtcct tacccaaatg
    15901 gtatcagatt agaaggtttt ccaaagtcag agtggtacta cttcgataaa aatggagtgc
    15961 tacaagagtt tgttggttgg aaaacattag agattaaaac taaagacagt gttggaagaa
    16021 agtacgggga aaaacgtgaa gattcagaag ataaagaaga gaagcgttat tatacgaact
    16081 attactttaa tcaaaatcat tctttagaga caggttggct ttatgatcag tctaactggt
    16141 attatctagc taagacggaa attaatggag aaaactacct tggtggtgaa agacgtgcgg
    16201 ggtggataaa cgatgattcg acttggtact atttagatcc aacaactggt attatgcaaa
    16261 caggttggca atatctaggt aataagtggt actacctccg ttcctcagga gcaatggcca
    16321 ctggctggta tcaggaaggt accacttggt attatttaga ccagccaaat ggcgatatga
    16381 aaacaggttg gcaaaacctt gggaacaaat ggtactatct ccgttcctca ggagcaatgg
    16441 caactggttg gtatcaagat ggttcaactt ggtactacct aaatgcaggt aatggagaca
    16501 tgaagacagg ttggttccag gtcaatggca actggtacta tgcttatagc tcaggtgctt
    16561 tggcagtgaa tacgaccgta gatggctatt ctgtcaacta taatggcgaa tgggttcggt
    16621 aatgacaggg cgcttataat tatattagaa cactcgctta atcaaagaag tgactttgtt
    16681 gtacttgacc tgacgattgg ggagattaaa agcatgtgaa atctacacat gctttttcgt
    16741 tagttatgag tgttgaacgt gactaaccat tgacaaaaga taagagcaat taaaataaga
    16801 tacaaaaata tcaatgctaa ctgcaccgaa acgcccgatg ctatggatag ggctaatagg
    16861 gagagcaggg acggggcgag aatgtctact gtgctcagag cagagcccac cgttcccatc
    16921 ttgtcactgg ggatatgggc aaagacagct gcttgtaggc gagggctgag aatgccgata
    16981 atcgtagaac tgatgaaact ggtcatgaaa attacgatat aggtttgaca aaggatacta
    17041 gttattagag ccaataggga aatctcacag aaaaccaaga ggtgcgtgaa acggatattt
    17101 ttaaatagat tactgctggt catattgcca aggatagctc cacaagaaat gatgatggag
    17161 agcagggcga ggagttgccc aatgctcagt tgtgctagtg tctgttggat gaagcggagg
    17221 gcaatcagcc gaggggacac atccaagatg gcaatcatac tggtcgtcag aaacagtagt
    17281 atgacggtat cttttaacct caggagcaca gccagcgact gtttaagatg ttgaaaatat
    17341 ttcttaaaac tcagtgctgt atgtgacatt tcaatctttt tttcaacctc atacaaggta
    17401 tgtcgaataa catacaggcc caaaaaggca atgacaaaag tcagagtgtt gataagggaa
    17461 atagtttgaa tactcataac attgataagg aatacgccag ccagattggc gacaatgcgg
    17521 acaaccctca tcagagactg cctgaacccc atggcatcat gcaggttgtc cttaattaca
    17581 ctgatgtaga gggcgttcat catgtaggca gacaggtagc tcaaggtgtc agagatgagg
    17641 ttgatgatga caatcataat gactgaaact aatgaaaagg gcgacaagac gagaaatact
    17701 gtcaaaatag cgtagagcag gattttgatt ttggcaatac agagtgcgtg tttgactcta
    17761 ttttcttgaa aatctcctaa aatcccgaga aagagttgcg atagtagggg aaccatctct
    17821 gaaatggaaa tcagtaaaat cgctagcgga gcgaaattgt attgagccac ataattgata
    17881 atggcgaggt agaaaatact gtcgccgaat gatgaaaaac agctgtttag cagcaactgt
    17941 ctatatatgt tgtttgtcca aaataatttc atacttttct ccttatgtct gcacatcgaa
    18001 tgggaattta ttatttaata gacaccaata taccccatgc ttcctattcc gaagtcaaac
    18061 aaatctgctt taccactatc tccttgaaac atcagtaaac cgtgatcatc tcgttcagaa
    18121 catgctaaaa ttacctgttg gatttttttc atcagtaatt tgttttgatt gtagacagtg
    18181 gtttgtagta ggctagttat tccgtggcaa tatcctgtca tcatttttag atgatggtta
    18241 aaaacaaatt cttgatattt actaataata tctttgtttc cgtcacaatc gtacatacaa
    18301 agatataaga ttattccgga aattcctttg caccaagaaa gttgtaaatt tcctaaattt
    18361 tcagtattag aagtaacttt ttctaataat
//
LOCUS       DAVHIZ010000039        17621 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.041, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000039 DAVHIZ010000000
VERSION     DAVHIZ010000039.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 17621)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 17621)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17621
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.041"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            25..634
                     /locus_tag="VVO18_001465"
                     /pseudo
     CDS             25..634
                     /locus_tag="VVO18_001465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000662948.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Type 1 glutamine amidotransferase-like
                     domain-containing protein"
     gene            916..1163
                     /locus_tag="VVO18_001466"
                     /pseudo
     CDS             916..1163
                     /locus_tag="VVO18_001466"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335280.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside phosphotransferase"
     gene            1268..1570
                     /locus_tag="VVO18_001467"
                     /pseudo
     CDS             1268..1570
                     /locus_tag="VVO18_001467"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            1726..2955
                     /locus_tag="VVO18_001468"
     CDS             1726..2955
                     /locus_tag="VVO18_001468"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEU5586598.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGISVNGA
                     YGWISVAGVTIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSATSVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            2975..5671
                     /gene="ppc"
                     /locus_tag="VVO18_001469"
     CDS             2975..5671
                     /gene="ppc"
                     /locus_tag="VVO18_001469"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HEU5586599.1"
                     /translation="MSLQKLENYSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITHKKSDTNTPNRYEAIMDQVVDRS
                     YDVYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     misc_binding    5754..5971
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            6084..7088
                     /locus_tag="VVO18_001470"
     CDS             6084..7088
                     /locus_tag="VVO18_001470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5586600.1"
                     /translation="MKNKRLIGIIAALAVLVAGSLIYSSMNKSEAQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSTGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     gene            7158..8024
                     /locus_tag="VVO18_001471"
     CDS             7158..8024
                     /locus_tag="VVO18_001471"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586601.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGHMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLSK"
     gene            8021..8779
                     /locus_tag="VVO18_001472"
     CDS             8021..8779
                     /locus_tag="VVO18_001472"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586602.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFEQDFITILGGN
                     GAGKSTLFNTIAGTISLTSGTIRILGEDVTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLFPRRLASYKDKFQATIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRVIQDLKQEEKAKMKISDYYQLFE"
     gene            8869..10629
                     /gene="dnaG"
                     /locus_tag="VVO18_001473"
     CDS             8869..10629
                     /gene="dnaG"
                     /locus_tag="VVO18_001473"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEU5586603.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVTFMEAVQILGQRVGIEVEKPLYSEQ
                     KPASPYQALYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPPE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDANQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTYKYKNSRSTAIFNKSYELYHMDRAKKSSGKTSEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAAILKALDEIGDMPVQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFIEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMERISRPTPITMPVT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            10632..11741
                     /gene="rpoD"
                     /locus_tag="VVO18_001474"
     CDS             10632..11741
                     /gene="rpoD"
                     /locus_tag="VVO18_001474"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HEU5586604.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELALAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            11755..12084
                     /locus_tag="VVO18_001475"
     CDS             11755..12084
                     /locus_tag="VVO18_001475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEU5586605.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            12199..13242
                     /gene="cpoA"
                     /locus_tag="VVO18_001476"
     CDS             12199..13242
                     /gene="cpoA"
                     /locus_tag="VVO18_001476"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HEU5586606.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAALKDLKEKAKNISREYSEEHLLQIW
                     LDFYEKQAALGRK"
     gene            13258..14583
                     /locus_tag="VVO18_001477"
     CDS             13258..14583
                     /locus_tag="VVO18_001477"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU5586607.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRPSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLVAFADVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TALYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDMNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLQQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            14614..14790
                     /locus_tag="VVO18_001478"
     CDS             14614..14790
                     /locus_tag="VVO18_001478"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEU5586608.1"
                     /translation="MRSGRDKKIAGVCAGVAHYLDMDPTIVQVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            14849..14983
                     /locus_tag="VVO18_001479"
     CDS             14849..14983
                     /locus_tag="VVO18_001479"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HEU5586609.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSNL
                     "
     gene            15047..16357
                     /gene="obgE"
                     /locus_tag="VVO18_001480"
     CDS             15047..16357
                     /gene="obgE"
                     /locus_tag="VVO18_001480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000061643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HEU5586610.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEEFKKKLSENYDEFEELPAIFPISGLTKQGLATLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            16367..16525
                     /locus_tag="VVO18_001481"
     CDS             16367..16525
                     /locus_tag="VVO18_001481"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586611.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
     gene            complement(16577..17621)
                     /locus_tag="VVO18_001482"
                     /pseudo
     CDS             complement(16577..17621)
                     /locus_tag="VVO18_001482"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000530076.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         5451 a         3015 c         3920 g         5235 t
ORIGIN      
        1 tgtatcttta gaaagtgtgt taacttgaaa gaacaaattt ttttgatggg tgggaatccc
       61 ccaatgaaga aatatagtat tgttgataaa attgtattat caaccaagat taaaagaatt
      121 atcattttta cagtttttcg agaaaattgg gaaccgtaca tgaaaaagta cacggaagtt
      181 tttcaaagtc aatttcctaa tctaaacatt gattacttgc tcctggacac tgagcagatt
      241 gatcttgata gctatctaga tgctgacata attatcatcg gtggtggaaa tacggaaaaa
      301 tatattgcta acttatgtta atcaggagtt caaaagttat atcgatcata tgcttaataa
      361 agaggcaaaa attataggat tttctgcagg agccctacta ttaggagaaa aagtctatgt
      421 ctcacctaat gataattcag atcatcagat aaagataaaa aatggattag gactctttag
      481 tcagttttta attagtgtcc attatgattc ctggaatgat aaagcaaata aggatagagc
      541 tgaagaactc gttaatgttc ccataattcc actaaatgat cattcttgtc ttgtattgga
      601 taaacttgga aacatcatag agaaaattga ctaactttca taatgtaaaa atggatctag
      661 gaaataaaag tgtagacgaa ctggataggt tactagtgaa aactgcaaaa agtgttgtaa
      721 agtgaatcgg agtgtgcttg atggatttta gtagtaagat agccataaat aaaggctggt
      781 cagatgataa aaaatattgt gtgacagatc aaaatcagta aaaatatttc ttgcgtgttt
      841 ctgataagtc gaagttagat tataaaaaaa tttgaatttg atatgatgga gaaagtagct
      901 tctcttggag ttccgatgtg taaaccaatt agcattgaac tctgcgatga cgaagtacat
      961 tctttacacg aatggataga cggaagagat gcaatagata gcattttagc ttattcagaa
     1021 aaccaacaat acacatatgg tgtagaagca ggaaagatac ttagaaagat tcatacaatt
     1081 cctgctacag aagtttgtga agattgggaa atttttttaa tctaaaaatt gatgataaaa
     1141 tctccaacga aatgatatgg taagtccgaa acgctcagtg tgtaagcttg ttgctaaaag
     1201 cgtaaaaacc ttggaacgaa aggaataata gacttcctgc gaaacaaaaa tacaatacaa
     1261 taaaactatg gatgatgaag caagtaaaca attaagcgat agccgtttca agatccttgt
     1321 aggtgttcag cgcacgactt ttgaagagat gttagctgtg ttaaaaacag cttatcaacg
     1381 taaacgcgca aaaggtggac gaaaaagcaa attaagccta gacgatctcc ttatggtaac
     1441 tattcaatac atgcgagaat agagcactta tgaacaaatt gcggctgatt ttggcattca
     1501 cgaaagcaac ttaatccgtc ggagtcaatg ggttgaagca actcttattc aaaatggttt
     1561 tacgatttca aattctgcct taattctgta aaaacagtaa aattcgaagg attgtaaggt
     1621 aagagttttt ttctttctga aaaaatggta taatagcaat caaaactaga aaataaaacg
     1681 gaatttggaa cagatttgtc tgtatcctag tagagtggtg atactatgaa gattagtaag
     1741 aggcacttat taaattattc catcttgatt ccctacttgc ttttatctat tttgggcttg
     1801 attgtggtct attcgaccac cagtgctatt ttaattgaag aaggcaagag cgccttgcag
     1861 ttggttcgaa accaaggaat cttttggatt gttagtttga tactgattgc cttaatttat
     1921 aaattgagac tagatttttt gagaaatgag cgactaatca ttttagttat attaatagaa
     1981 atgcttttat tgttcttggc tcgttttatt ggtatttcag taaacggggc atacggttgg
     2041 atttcggttg caggagtaac tattcagcca gctgagtact taaaaatcat tattatttgg
     2101 tatttagctc accgattctc caaacagcaa gaagaaatag ctacttatga ttttcaagtt
     2161 ttgactcaaa atcaatggct tccccgtgct tttaatgatt ggcgattcgt tctcctagtt
     2221 ctgattggaa gtttgggaat tttccctgat ttaggaaatg cgactatttt agtcttggtt
     2281 tccttgatta tgtatacagt tagtggaatc gcttatcgct ggttttcaac cattctggcg
     2341 ctcgtatctg ccacttctgt ctttgtcttg accactatca gcctaatcgg tgttgagacc
     2401 ttttcaaaaa ttccagtatt tggctatgta gccaagcgct ttagtgcctt ttttaatcct
     2461 tttgccgatc gtgctgatgc aggtcaccag ttagctaatt cttattttgc catggtcaat
     2521 ggtggttggt ttggtctagg tcttggaaac tcgattgaaa aacgaggtta tttgccagaa
     2581 gctcatacag actttgtctt ttctatcgtg attgaagaat ttggctttgt tggtgccagt
     2641 cttattttag ctctcttgtt tttcatgatt ttgcggatta tcttggtcgg tatccgagcg
     2701 gagaatcctt tcaatgccat ggttgcactc ggtgtcggag ggatgatgtt ggttcaggta
     2761 tttgtcaata tcggagggat ttcgggcttg attccatcta caggagtgac tttccctttc
     2821 ttatcccagg gtggaaatag tcttctagtc ttatcagtgg cagtagcctt tgtcttaaat
     2881 attgatgcca gtgaaaaacg cgctaagttg taccgagaat tggaaaatca accaatgaac
     2941 cttctgttga agtaggataa agaaaggata gtttatgtct cttcaaaaat tagaaaatta
     3001 tagtaataaa agtgttgtgc aagaagaagt cttgattcta acagaattac tggaagatat
     3061 tactaaaaat atgcttgccc cagagacctt tgaaaaaata atacagttga aagaattatc
     3121 aacgcaggaa gattatcaag gtctaaaccg tctagtgact agcttatcaa atgatgaaat
     3181 ggtctatatt tcacgctatt tctctatctt acctcttttg attaatattt cagaggatgt
     3241 ggatttagct tatgaaatca atcatcaaaa taatattgat caggactatt taggtaaatt
     3301 atctacaacg attaaattgg tagcagaaaa ggaaaatgcc gttgagatcc tagaacactt
     3361 gaatgttgtc cctgttttga cagcccatcc aacacaagtg caacgcaaaa gtatgttgga
     3421 tttaacaaat catattcata gtcttttgcg taaataccgt gatgttaagt tggggttgat
     3481 caataaagat aaatggtaca atgatttgcg tcgttacatc gaaattatca tgcagacaga
     3541 catgattcgt gagaaaaaat taaaagtgac taacgaaatc acgaatgcta tggaatatta
     3601 taacagctcc tttttgaaag ctgtacctca tttgacgacg gagtataagc gcttagcgca
     3661 agcgcatggt ctgaatttaa aacaggctaa accaatcacc atgggtatgt ggataggtgg
     3721 tgaccgtgat ggaaatccat ttgttacagc aaagaccttg aagcagtctg cactcactca
     3781 gtgtgaagtc atcatgaact actatgataa aaagatttac caactttatc gtgaattttc
     3841 tctttcaact agcattgtca acgtcagcaa gcaagtcaga gaaatggctc gtcaatccaa
     3901 ggataactcg atttaccgcg aaaaagagct ttaccgtcgt gccttgtttg atattcaatc
     3961 aaaaattcag gcaactaaaa cctatctgat tgaggatgaa gaagttggga ctcgttatga
     4021 aaccgccaat gatttctaca aggatttgat tgccattcga gattctctac tagaaaataa
     4081 gggcgagtcc ttgatttcag gtgattttgt ggaattattg caggcagtag agatatttgg
     4141 tttttactta gcatcaattg atatgcgaca agactctagc gtctatgaag cctgtgtggc
     4201 agaactcttg aaatcagcag gaattcattc tcgttatagc gagttgagcg aagaagaaaa
     4261 gtgtgacctt ctcttgaaag aattagaaga agatccccga attctttctg cgactcacgc
     4321 agaaaaatca gaattattag caaaagaatt agctattttt aagacggctc gtgttttgaa
     4381 agataagttg ggagatgatg tcatccgtca gaccatcatt tcacatgcaa ccagcctttc
     4441 tgatatgcta gaattagcta ttctgttaaa agaagtagga ctggtggata cggaaagggc
     4501 gcgtgttcag attgttcccc tttttgaaac aattgaagac ttggatcatt cagaggaaac
     4561 aatgagaaaa tatctttctc ttagccttgc caaaaaatgg attgactcac gaaataacta
     4621 ccaagaaatc atgcttggct actctgacag taataaagat ggcggttact tgtcatcatg
     4681 ttggaccctc tacaaggctc aacaacaatt gactgctatt ggagatgaat ttggcgttaa
     4741 ggttaccttc ttccatggtc gtggtggtac tgtcggtcgt ggtggtgggc caacctatga
     4801 agccattaca tctcaaccgc tcaagtctat caaggatcgt atccgtttga cggagcaggg
     4861 tgaagtaatt gggaataaat acggtaacaa agacgccgct tactataacc ttgaaatgct
     4921 agtatctgca gctattaacc gtatgattac tcataagaag agtgatacca ataccccaaa
     4981 tcgttatgaa gccattatgg atcaagtagt ggaccgtagt tacgatgtct accgtgattt
     5041 ggtctttggt aatgagcatt tctatgatta tttcttcgag tcaagtccaa tcaaggctat
     5101 ttcaagtttt aatattggtt ctcgtccagc cgctcgtaag actattactg aaatcggtgg
     5161 tttgcgtgcc atcccttggg tattctcatg gtcacagagt cgtgttatgt tccctggatg
     5221 gtacggggtt ggttcaagct tcaaggaatt tatcaataaa aatccagaga atattgctat
     5281 cttacgagat atgtaccaaa attggccttt cttccaatcg cttctttcaa atgttgatat
     5341 ggttttgtca aaatcaaata tgaatattgc ttttgaatat gctaaacttt gtgaagacga
     5401 gcaagttaag gccatctatg agactatttt aaatgaatgg caagttacta agaacgttat
     5461 cttggctatt gaaggacatg acgaactctt agctgacaat ccatatctaa aagctagtct
     5521 ggattaccgt atgccttact ttaatattct caactatatt cagttagagt tgattaaacg
     5581 ccaacgtcgt ggagaattgt ccagtgatca agaacgattg attcatatca ccatcaacgg
     5641 aattgcgaca ggattgcgta attcaggttg ataattttca agagtgaatg ctaaaagtga
     5701 atatcaaaaa aattctaata gactattgac aagtagttta aaaatgatat aatttaacca
     5761 ttcagaaaag taatcataca aactttttag agagtctgtg gtagctgaaa acagataagt
     5821 ggcaatgatg aaaattgggc tgaatgctat ttagaatttg aaattataaa aattcggtaa
     5881 gcacacctta cagtgcatct cgttattgcg agactgagcg atagggaaat tccctataat
     5941 tgaggtggta ccgcgcatcg acgtcctcac acaagttttt tgtgtgagga tttttttgat
     6001 ggaggttagt atggaaagaa aacaatggcg tcgcttgttt agataagtga aatatgttaa
     6061 aggaaataaa aaggagaaac agaatgaaaa ataaacgttt aattggaatt attgctgcat
     6121 tagcagtctt agtagcagga agcttgattt attcttcaat gaataaatca gaagctcaga
     6181 ataataagga tgagaagaaa ataaccaaga ttggtgtgct tcaatttgtg agccatccat
     6241 cccttgattt gatttataaa gggatccaag atggacttgc agaagaagga tataaagatg
     6301 atcaagttaa aattgatttt atgaactcag aaggtgacca aagtaaggtt gcgacaatga
     6361 gtaaacaatt ggttgcaaat gggaatgacc ttgtggttgg tatcgcaaca ccagcagccc
     6421 aagggttggc tagtgcaaca aaagacctac cggttatcat ggccgctatt acagacccaa
     6481 ttggtgctaa cttggttaaa gatttgaaaa aaccaggtgg caacgttaca ggggtatctg
     6541 accacaatcc agctcaacaa caagttgaac tcatcaaggc tctgacaccg aatgtgaaaa
     6601 caatcggagc tctttactca agtagcgaag acaattcaaa aacacaggtc gaagaattta
     6661 aggcttatgc tgaaaaagca ggtctgacag tggaaacatt tgcagttcct tcaacaaatg
     6721 aaattgcctc aactgtcact gttatgacta gcaaggtaga tgctatttgg gttccaattg
     6781 ataacaccat tgcatcagga tttccaacgg ttgtctctag caatcaaagt tctaagaaac
     6841 caatttatcc cagtgcgaca gctatggtag aagtaggtgg tttggcatca gttgtaattg
     6901 accaacatga ccttggtgtg gcaacaggta aaatgattgt gcaagtcttg aaaggtgcaa
     6961 aaccagccga taccccagtc aatgtctttt caactggtaa gtcagtcatc aataaaaaaa
     7021 tagcacaaga actaggtatt actattcctg agtctgttct caaagaagca ggacaagtca
     7081 tcgaataaat aaggtaggga ggaggagact cttcccattt tttaaaaaga tgaattatag
     7141 aaaggattaa ataaaatatg attgtttcca ttatttctca aggatttgtc tgggctattc
     7201 taggtctggg aatctttatg acatttagga ttttaaactt tccagatatg acgacagaag
     7261 gttccttccc tcttggggga gctgttgctg tcactttgat aaccaaaggc gtgaacccat
     7321 ttttagcgac acttgttgct gtaggagcag gttgtttggc tggaatggca gcaggccttc
     7381 tttatacaaa agggaagatc ccaaccttgc tctcagggat tttggtgatg acttcttgtc
     7441 actcaatcat gctcttgatt atgggacgtg cgaatttagg cctgcttgga accaagcaaa
     7501 ttcaggatgt tttgcctttt gattcggatt tgaatcaact cttgacaggt ctcatctttg
     7561 tgagtattgt tattgctctc atgctctttt tcttggacac taaactcgga caagcctata
     7621 ttgctacagg ggataatcct gatatggcta gaagtttcgg gattcatact ggacacatgg
     7681 agctcatggg cttggtctta tcaaatggtg tgattgccct tgcaggtgcc ctcattgctc
     7741 agcaagaagg ttatgccgat gtgtctcgag ggatcggggt tatcgttgtg gggcttgcaa
     7801 gtttgattat tggagaagtt attttcaaga gtttgagctt ggcagagcgt ttggttacta
     7861 tcgttgtagg ttctatcgct tatcaatttt tagtgtgggc agttatcgca cttggcttta
     7921 atacaagtta ccttcgttta tacagtgcct tgattttagc agtctgcctc atgattccaa
     7981 catttaagca aacaatcttg aaaggagcca agttaagcaa atgacagcaa ttgtagaatt
     8041 aaaaaatgca accaaaatcg ttaaaaatgg ctttgatgaa gaaaagatta ttttaaatga
     8101 tgtttcctta gaaatttttg aacaggactt tatcacgatt ttgggtggaa atggtgctgg
     8161 taaatcaacc ctctttaaca ctattgcagg aaccatatca ctaaccagtg gaactatccg
     8221 tattttaggt gaggatgtta ccaagttttc accagagaag cgcgctaagt atctgtctcg
     8281 agtcttccaa gatccaaaga tggggacagc tcctcgtatg acagtggcag agaatctcct
     8341 gattgccaag tttcgtggtg aaaagcgtgg actatttccg agacgtctgg ctagctataa
     8401 ggataagttt caggcgacca ttgaaaaagt gggaaacggt cttgagaaac acttgaatac
     8461 accgattgag ttcttatctg gtggacaaag acaggctttg agtctcttga tggcaacctt
     8521 gaagcgacct gaattactct tgttagacga gcatactgct gccctggatc caaagactag
     8581 tgttgctttg atggaattga cagatgaatt tgttaagaaa gatcaattga cagcccttat
     8641 gattacccat catatggaag atgctctcaa atatggcaat cgcttgattg tcatgaaaga
     8701 aggacgggtt atccaagatt tgaaacaaga agaaaaagca aaaatgaaaa tctctgatta
     8761 ttatcaactc tttgaataaa gtagggaaaa tgagtgaaat ggtttacttt ttttctgaaa
     8821 taaagtatac tatataaagt aaactatgat aacatggagg tattgtgtat ggttgacaaa
     8881 caagtcattg aagaaatcaa aaacaatgcc aacattgtgg aagtcatagg agatgtgatt
     8941 tctttacaaa aggcaggacg gaactatcta gggctctgtc cttttcatgg tgaaaaaaca
     9001 ccttctttca acgttgtaga ggacaagcag ttttaccact gttttggttg tggtcgctca
     9061 ggtgatgtct ttaaattcat cgaggagtac caaggggtta cctttatgga ggctgtccaa
     9121 atcttaggtc agcgtgtcgg gattgaggtt gaaaaaccgc tttatagtga acagaagcca
     9181 gcctcgcctt accaagctct ttatgatatg cacgaagatg cggctaaatt ttaccatgct
     9241 attctcatga caacgactat gggcgaagag gccagaaatt acctttatca gcggggtttg
     9301 acagatgaag tgcttaaaca tttttggatt ggtttagcac ctccagaacg aaactatctc
     9361 tatcaacgtt tgtctgatca gtatcgtgaa gaggatttac tggattcagg cctgttttat
     9421 ctctcggatg ccaatcaatt tgtagacacc tttcacaatc gcattatgtt tcccctgaca
     9481 aatgaccaag gaaaggtcat tgccttctca ggtcgtatct ggcaaaaaac ggattcacaa
     9541 acttataagt ataaaaacag ccgatcgact gcaattttta acaaaagtta cgaattatat
     9601 catatggata gggcaaaaaa atcttctgga aaaactagtg agatttacct gatggaagga
     9661 ttcatggatg ttattgcagc ctatcgggct ggaatcgaaa atgctgtggc gtcgatggga
     9721 acggccttga gtcgagagca tgttgagcat ctgaaaaggt taaccaagaa attggttctt
     9781 gtttacgatg gagataaggc tgggcaagcc gcgatattga aagcattgga tgaaattggt
     9841 gatatgcctg tgcaaatcgt tagcatgcct gataacttgg atcctgatga gtatctacaa
     9901 aaaaatggtc cagaagactt ggcctatcta ttaacaaaaa ctcgtattag tccgattgag
     9961 ttctacattc atcagtacaa acctgaaaac agtgaaaatc tgcaggctca gattgagttt
    10021 attgaaaaaa tagctccctt gattgttcaa gaaaagtcca tcgctgctca aaacagctat
    10081 attcatattt tagctgacag tctggcgtcc tttgattata cccagattga gcagattgtt
    10141 aatgagagtc gtcaggtgca aaggcagaat cgcatggaaa gaatttccag accgacgcca
    10201 atcaccatgc ctgtcaccaa gcagttatcg gctattatga gggcagaagc ccatctactc
    10261 tatcggatga tggaatcccc tcttgttttg aacgattacc gtttgcgaga agactttgca
    10321 tttgctacac ctgaatttca ggtcttatat gacttgcttg gccagtatgg aaatcttcct
    10381 ccagaagttt tagcagagca gacagaggaa gttgaaagag cttggtacca agttttagct
    10441 caggatttgc ctgctgagat atcgccgcag gaacttagtg aagtagagat gactcgaaac
    10501 aaggctctct tgaatcagga caatatgaga atcaaaaaga aggtgcagga agctagccat
    10561 gtaggagata cagatacagc tctagaagaa ttggaacgtt taatttccca aaagagaaga
    10621 atggagtaat aatggcaaca aaacaaaaag aagtaacaac atttgacgta caggtagcag
    10681 aatttatccg taatcataag caaaaaggga cagcaacaga tgatgaaatc aatgcaagtc
    10741 tggttattcc ttttaccttg gacgctgatg ggattgaaga tctcttgcaa cggattcagg
    10801 atgcaggcat ttctatcaca gataacgaag gaaatccaag tgcgcgtgtt cttagcaatg
    10861 aagaagaacc agaactcagc gatgaggact tgattgggtc aacttctgct aaggtcaatg
    10921 accctgtccg tatgtacttg aaagaaatag gggtcgttcc tctcttgacc aatgaagagg
    10981 agaaagagtt ggcactggct gttgaagctg gcgatatcga agccaaacaa cgtcttgcgg
    11041 aagccaatct tcgtttggtt gtttccattg ccaaacgcta tgtcggtcgt ggcatgcagt
    11101 tccttgactt gattcaagaa ggaaatatgg gcttgatgaa ggcggttgac aagtttgact
    11161 attctaaagg gttcaagttt tcaacttatg caacttggtg gattcgtcag gctatcactc
    11221 gtgctattgc ggaccaagct cgtaccatcc gtatcccagt tcacatggtt gaaactatca
    11281 ataaattggt tcgtgaacag cggaatctcc ttcaagaatt ggggcaagat ccgacaccag
    11341 aacagattgc tgaacgaatg gatatgacac ctgataaggt tcgtgaaatc ttgaagattg
    11401 cccaagaacc agtatctctt gaaactccta tcggtgaaga ggacgatagc caccttggag
    11461 actttatcga agatgaagtg attgaaaatc cagtggatta tacgactcgt atcgtcttgc
    11521 gtgagcaatt ggatgaaatc ttagatactc ttacagaccg tgaagaaaat gttctgcgtc
    11581 tacgttttgg actagatgat ggaaaaatgc gcacacttga agatgtgggg aaagtcttta
    11641 acgtaactcg tgagcgtatc cgtcagattg aagcaaaggc tttgagaaaa ctacgccaac
    11701 caagtcgcag caaaccgctt cgtgatttta ttgaagacta agagtgagga aaatatggct
    11761 tatacagaag agcaaattga aaacatcaaa acacggattt taacagcctt ggaagaagtc
    11821 atcgaccctg agttgggaat cgatattgtc aatcttggtt tgatctatga gattcgtttt
    11881 gacggtgaca cagggcaaac agagattgac atgactttga caactatggg ttgtccctta
    11941 gcagaccttt tgacagacca gatttatgat gctatgatag aggttccaga agtaacggat
    12001 actgaggtta aattagtctg gtatccagcc tggacagttg aaaaaatgag tcgctatgcc
    12061 cgcattgccc taggcattaa gtaaacatat aaaagcatgt gagagactgt tggaaaagcg
    12121 aggaaatttc ccctcttttc ctctagtctc tcctttcttt tgctgatttt attcaaagaa
    12181 aatgatataa tagtagttat ggagaaaaag aaattacgca tcaatatgtt gagttcaagt
    12241 gagaaagtag caggacaggg agtttcaggt gcttaccgtg aattagttcg tcttcttcac
    12301 cgtgctgcca aggaccaatt gattgttaca gaaaatcttc cgatcgaggc agatgtgact
    12361 cactttcata cgattgattt tccctattat ttatcaacct tccaaaagaa acgctcaggg
    12421 agaaagattg gctatgtgca tttcttgcca gctacacttg agggaagttt gaaaattcca
    12481 tttttcttaa agggaattgt gaaacgctat gtattttctt tttacaaccg gatggagcac
    12541 ttggttgtgg tcaatcctat gtttattgag gatttggtag cagctggtat tccacgtgaa
    12601 aaagtgacct atattcctaa ctttgtcaac aaggaaaaat ggcatcctct accacaagaa
    12661 gaggtagtca gactgcgcac agatcttggt cttagtgaca atcagtttat cgtagtaggt
    12721 gctgggcaag ttcagaaacg taaagggatt gatgacttta tccgtctggc tgaggaattg
    12781 cctcagatta cctttatctg ggctggtggc ttctcttttg gtggtatgac agatggttat
    12841 gaacactata agaaaattat ggaaaatccc cctaaaaatt tgatttttcc aggcattgta
    12901 tcgccagagc ggatgcgcga attgtatgct ctagcggatc ttttcttgtt gcctagttac
    12961 aatgagctct ttcctatgac tattttagaa gctgcgagtt gtgaggctcc tattatgttg
    13021 cgtgatttag atctctataa ggtgattttg gagggaaatt atcgggcgac agcgggtaga
    13081 gaagagatga aagaggctat tttggaatat caagcaaatc ctgctgcctt aaaagatctc
    13141 aaagaaaagg ctaagaatat ttccagagag tattctgaag agcatctgtt acaaatctgg
    13201 ttggactttt atgagaaaca agccgcttta gggagaaagt aaaaagtgag gtaatctatg
    13261 cgaattggtt tatttacaga tacctatttt cctcaggttt ctggtgttgc gaccagtatt
    13321 cgaaccttga aaacagaact tgaaaagcag ggacatgctg tttttatctt tacgacgaca
    13381 gataaggatg tcaatcgcta cgaagattgg caaattatcc gcattccaag tgttcctttc
    13441 tttgctttta aggatcgtcg ctttgcctac cgaggtttta gcaaggcact tgaaattgct
    13501 aaacagtatc agctagatat tatccatact cagacagaat tttctcttgg cctgttgggg
    13561 atttggattg cgcgtgaatt gaaaattcca gtcatccata cctatcacac ccagtatgaa
    13621 gactatgtcc attatattgc taaggggatg ttgatccgac cgagtatggt caagtatctg
    13681 gttagaggtt tcctgcatga tgtggatggg gttatttgcc ctagtgagat tgtccgtgac
    13741 ttgctatctg attataaggt caaggttgaa aaacgggtca ttcctactgg gattgaatta
    13801 gccaagtttg agcgtccgga aatcaagcag gaaaatttga aagaactgcg tagtaaacta
    13861 gggattcaag atggtgaaaa gacgttgctt agtctttcga gaatctccta tgaaaaaaat
    13921 attcaagcag ttttagtagc ctttgctgat gttctgaaag aggaagacaa ggttaaactg
    13981 gtagtagctg gggatggccc ttatctgaat gacctcaaag agcaagccca gaacctagag
    14041 attcaagact cagtcatctt tacagggatg attgctccta gtgagacggc tctttactat
    14101 aaagcggcgg attttttcat ttcggcatcg acaagcgaaa cgcaaggttt gacctacttg
    14161 gaaagcttag ccagtggaac acctgtcatt gctcacggaa atccttattt gaacaacctc
    14221 atcagtgata aaatgtttgg aaccttgtac tatggagaac atgatttggc tggtgctatt
    14281 ttggaagccc tgattgcaac accagacatg aacgagcata ccttatcaga gaaattgtat
    14341 gagatttcag ctgagaactt tgggaaacga gtgcatgagt tttatctgga tgccattatt
    14401 tcaaataact tccagaaaga tttggctaaa gatgatacgg tcagtcagcg tatctttaag
    14461 acagttttgt atcttcagca acaggtggtt gctgtacctg taaaaggatc tagacgcatg
    14521 ttgaaggctt caaaaacaca gttgatcagt atgagagact attggaaaga ccatgaagaa
    14581 tagaaagagg aacagctatg aaaaaaacaa ttaatgagaa gcggtcgtga taaaaagatt
    14641 gcgggtgttt gtgctggggt ggcccattat ctggatatgg atccgactat cgttcaagtc
    14701 atttggggtg ttcttacttg ctgttacgga gctggaattg tagcttacat tattttatgg
    14761 attatcgcac cagtagcaac tgactattga aaactagctc aattcatgct aagataatag
    14821 aaaatagaat gtaacgaagg agagaaaaat ggcatttgga gataatggaa atcgtaaaaa
    14881 aactatgttt gagaaaataa ccttgtttat cgtgattatc atgctagtag caagtttatt
    14941 gggaattttt gcaactgcaa ttggtgccct cagtaatcta taaaatagat tcaagaaaat
    15001 ttagtgactg ggatttccca gccctttttt aaagtgagaa gaaataatga gtatgttttt
    15061 agatacagct aagattaagg tcaaggctgg taatggtggc gatggtatgg ttgcctttcg
    15121 tcgtgaaaaa tatgtcccta atggaggccc ttggggtggt gatggtggtc gtggaggcaa
    15181 tgtggtcttc gttgtagacg aaggactacg taccttgatg gatttccgct acaatcgtca
    15241 tttcaaggct gattctggtg aaaaagggat gaccaaaggg atgcatggtc gtggtgctga
    15301 ggaccttaga gttcgagtac cacaaggtac gactgttcgt gatgcggaga ctggcaaggt
    15361 tttaacagat ttgattgaac atgggcaaga atttatcgtt gcccacggtg gtcgtggtgg
    15421 acgtggaaat attcgtttcg cgacaccaaa aaatcctgca ccggaaatct ctgaaaatgg
    15481 agaaccaggt caggaacgtg agttacaatt ggaactaaaa atcttggcag atgtcggttt
    15541 agtaggattc ccatctgtag ggaagtcaac acttttaagt gttattacct cagctaagcc
    15601 taaaattggt gcctaccact ttaccactat tgtaccaaat ttaggtatgg ttcgcaccca
    15661 atcaggtgaa tcctttgcag tagccgactt gccaggtttg attgaagggg ctagtcaagg
    15721 tgttggtttg ggaactcagt ttctccgtca catcgagcgt acacgtgtta tccttcacat
    15781 cattgatatg tcagctagcg aaggccgtga tccatatgag gattacctag ctatcaataa
    15841 agagctggag tcttacaatc ttcgcctcat ggagcgtcca cagattattg tagctaataa
    15901 gatggatatg cctgagagtc aggaaaatct tgaagaattt aagaaaaaat tgtctgaaaa
    15961 ttatgatgaa tttgaagagt taccagctat cttcccaatt tctggattga ccaagcaagg
    16021 tctggcaaca cttttagatg ctacagctga attgttagac aagacaccag aatttttgct
    16081 ctacgacgag tccgatatgg aagaagaagc ttactatgga tttgacgaag aagaaaaagc
    16141 ctttgaaatt agtcgtgatg acgatgcgac atgggtactt tctggtgaaa aactcatgaa
    16201 actctttaat atgaccaact ttgatcgtga tgaatctgtc atgaaatttg cccgtcagct
    16261 tcgtggtatg ggggttgatg aagcccttcg tgcgcgtgga gctaaagatg gggatttggt
    16321 ccgcattggt aaatttgagt ttgaatttgt agactaggag actggtatgg gagataaacc
    16381 gatatctttc cgagatgcgg atggtaattt tgtttccgcc gcagacgttt ggaatgaaaa
    16441 gaaattggaa gaactattta atcgtctcaa tccaaatcgt gccttgagat tggcacgaac
    16501 taaaaaggaa aatccatctc agtaaagaag ctaaaaaatc ccggctcttt gtcaactgta
    16561 gtgggttgaa aaaaagctaa gcttgagaaa ggacaaattt tgtcctttct tttttgatgt
    16621 tcagagcgat gaaaatccgt tttttgaagt tttcaaagtt tcgaaaacca aaggcattgc
    16681 gcttgataag tttgatgaga ttattggtcg cttccagttt ggcgttagaa tagtgtagtt
    16741 gaagggtgtt gacaagcttt tctttatctt tgaggaaggt tttaaagaca gtctgaaaaa
    16801 taggatgaac ctgcttaaga ttgtcctcaa taagtccgaa aaatttctcc ggttccttat
    16861 tctgaaagtg aaacagcaag agttgataga gctgatagtg gtgtttcaag tcttccgaat
    16921 aactcaaaag cttgtttaaa atctctttat tggttaagtg catacgaaaa gtaggacgat
    16981 aaaatcgctt atcactcagt ttacggctat cctgttgtat gagcttccag tagcgcttga
    17041 tagccttgta ttcatgagac tttcgatgaa actgattcat gatttgaaca cgcacacgac
    17101 tcatagcacg gctaagatgt tgtacaatgt gaaagcgatc aagaacaatt tttgcattcg
    17161 ggagtgaaac agtctgggag actgtttcag cctgagccta gaaatttgaa agcgaagttg
    17221 tttagccaag tcatagtaag gactaaacat atccatcgta atgattttca cttgacaacg
    17281 aacggctcta tcgtagcgaa gaaagtgatt tcggatgaca gcttgtgttc tgccttcaag
    17341 aacagtgata atattaagat tatcaaaatc ttgcgcaatg aagctcatct ccatctcccg
    17401 attgaaacag tcactccccg gactgtttca acctcccaag acataatctc aggcagattt
    17461 ctaaaattac actcaaagtg gaagtcattg agcttgcgaa tgacagttga agttgaaatg
    17521 gccagctgat gggcaatatc agtcatagaa attttttcaa ttaacttttg agcaattttt
    17581 tggttgatga tacgagggat ttggtgattt ttctttacca g
//
LOCUS       DAVHIZ010000040        16249 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.042, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000040 DAVHIZ010000000
VERSION     DAVHIZ010000040.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16249)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16249)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16249
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.042"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1527
                     /gene="rlrA"
                     /locus_tag="VVO18_001483"
     CDS             <1..1527
                     /gene="rlrA"
                     /locus_tag="VVO18_001483"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933118.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus transcriptional regulator RlrA"
                     /protein_id="HEU5586612.1"
                     /translation="LNKYIEKRITDKITILNILLDIRSIELDELSTLTSLQSKSLLSI
                     LQELQETFEEELTFNLDTQQVQLIEHHSHQTNYYFHQLYNQSTILKILRFFLLQGNQS
                     FNEFTQKEYISIATGYRVRQKCGLLLRSVGLDLVKNQVVGPEYRIRFLIALLQFHFGI
                     EIYDLNDGSMDWVTHMIVQSNSQLSHELLEITPDEYVHFSILVALTWKRREFPLEFPE
                     SKEFEKLKNLFMYPILMEHCQTYLEPHANMTFTQEELDYIFLVYCSANSSFSKDKWNQ
                     EKKTHTIQLILQHTRGKHLLSKFKNILGNDISNSLSFLTALTFLTRTFLFGLQNLVPY
                     YNYYEHYGIESDKPLYHISKAIVQEWMTEQKIEGVIDQHRLYLFSLYLTETIFSSLPA
                     IPIFIILNNQADVNLIKSIILRNFTDKVASVTGYNILISPPPSEEHLTEPLIIITTKE
                     YLPYVKKQYPKGKHHFLTIALDLHVSQQRLIYQTIVDIRKEAFDKRVAMIAKKAHYLL
                     "
     gene            1792..3054
                     /locus_tag="VVO18_001484"
     CDS             1792..3054
                     /locus_tag="VVO18_001484"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="HEU5586613.1"
                     /translation="MEHINHTTLLIGIKDKNITLNKAIQHDTHIEVFATLDYHPPKCK
                     HCKGKQIKYDFQKPSKIPFIEIGGFPSLIHLKKRRFQCKSCRKVTVAETTLVQKNCQI
                     SEMVRQKIAQLLLNREALTHIASKLAISTSTSTVYRKLKQFHFQEDYTTLPEILSWDE
                     FSYQKGKLAFIAQDFNTKKIMTILDNRRQTTIRNHFFKYSKEARKKVKVVTVDMSGSY
                     IPLIKKLFPNAKIVLDRFHIVQHMSRALNQTRINIMKQFDDKSLEYRALKYYWKFILK
                     DSRKLSLKPFYARTFRETLTPRECLKKIFTLVPELKDYYDLYQLLLFHLQEKNTDQFW
                     GLIQDTLPHLNRTFKTTLSTFICYKNYITNAIELPYSNAKLEATNKLIKDIKRNAFGF
                     RNFENFKKRIFIALNIKKERTKFVLSRA"
     gene            complement(3112..5436)
                     /gene="pflB"
                     /locus_tag="VVO18_001485"
     CDS             complement(3112..5436)
                     /gene="pflB"
                     /locus_tag="VVO18_001485"
                     /EC_number="2.3.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate C-acetyltransferase"
                     /protein_id="HEU5586614.1"
                     /translation="MVVKTVVEAQDIFDKAWEGFKGVDWKEKASVSRFVQANYTPYDG
                     DESFLAGPTERSLHIKKIVEETKAHYEETRFPMDTRPTSIADIPAGFIDKENEVIFGI
                     QNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIR
                     RARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAIKEIDEETIRLRE
                     EVNLQYQALQQVVRLGDLYGVDVRKPAMNVKEAIQWVNIAFMAVCRVINGAATSLGRV
                     PIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDQLYSGDPTFITTS
                     MAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDKLPYNFRRYCMHMSHKHS
                     SIQYEGVTTMAKDGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNG
                     GYDDVHKDYKVFDIDPIRDEVLEFESVKANFEKSLDWLTDTYVDALNIIHYMTDKYNY
                     EAVQMAFLPTKQRANMGFGICGFANTVDTLSAIKYATVKPIRDEDGYIYDYETIGDYP
                     RWGEDDPRSNELAEWLIEAYTTRLRSHKLYKDAEATVSLLTITSNVAYSKQTGNSPVH
                     KGVYLNEDGSVNLSKLEFFSPGANPSNKAKGGWLQNLNSLSSLDFSYAADGISLTTQV
                     SPRALGKTRDEQVDNLVTILDGYFENGGQHVNLNVMDLNDVYEKIMSGEDVIVRISGY
                     CVNTKYLTPEQKTELTQRVFHEVLSMDDALDALS"
     gene            5784..6845
                     /gene="dinB"
                     /locus_tag="VVO18_001486"
     CDS             5784..6845
                     /gene="dinB"
                     /locus_tag="VVO18_001486"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000904550.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase IV"
                     /protein_id="HEU5586615.1"
                     /translation="MLIFPLLNDLSRKIIHIDMDAFFAAVEIKDNPKLRGKPVIIGSD
                     PRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKAVGLQIRAI
                     FKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGISYNKF
                     LAKMASDYQKPHGLTVILPEQAENFLKQMDISKFHGVGKKTVERLHQMGVFTGADLLE
                     VPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILRAEEDIKKEL
                     TILSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSLAQKTQDASQISQIALQLYE
                     ELSEKERGVRLLGITLTGF"
     gene            complement(6992..7837)
                     /locus_tag="VVO18_001487"
     CDS             complement(6992..7837)
                     /locus_tag="VVO18_001487"
                     /EC_number="3.6.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000273482.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="HEU5586616.1"
                     /translation="MYLIEILKSIFFGIVEGITEWLPISSTGHLILAEEFIQYQNQNE
                     AFMSMFNVVIQLGAILAVIVIYFNKLNPFKPTKDKQEVRKTWRLWLKVLIATLPLLGV
                     FKFDDWFDTHFHNMVSVALMLIIYGVAFIYLEKRNKARAIEPSVTELDKLPYTTAFYI
                     GLFQVLALLPGTSRSGATIVGGLLNGTSRSVVTEFTFYLGIPVMFGASALKIFKFVKA
                     GELLSFGQLFLLLVAMGVAFAVSMVAIRFLTSYVKKHDFTLFGKYRIVLGSVLLLYSF
                     VRLFV"
     gene            8093..8961
                     /locus_tag="VVO18_001488"
                     /pseudo
     CDS             8093..8961
                     /locus_tag="VVO18_001488"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841243.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(9262..11151)
                     /locus_tag="VVO18_001489"
     CDS             complement(9262..11151)
                     /locus_tag="VVO18_001489"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750662.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2207 domain-containing protein"
                     /protein_id="HEU5586617.1"
                     /translation="MKKTFFLLVLGLFCLLPLSVFAIDFKINSYQGDLYIHADNTAEF
                     RQKIVYQFEEDFKGQIVGLGRAGKMPSGFDIDPHPKVQAAKNGAELADVTSEVTEEAD
                     GYTVRVYNPGQEGDIVEVDLVWNLKNLLFLYDDIAELNWQPLTDSSESIEKFEFHVRG
                     DKGAEKLFFHTGKLFREGTIEKSNLDYTIRLDNLPAKRGVELHAYWPRTDFASARDQG
                     LKGNRLEEFNKIEDSIVREKDQSKQLVTWVLPSILSISLLLSVCFYFIYRRKTTPSVK
                     YAKNHRLYEPPMELEPMVLSEAVYSTSLEEVSPLVKGAGKFTFDQLIQATLLDVMDRG
                     NVSIISEGDAVGLRLVKEDGLSRFERDCLNLAFSGKKEATLSNLFADYKVSDSLYRGA
                     KAADEKRIQARGIQLKSSFEAVLKEMQEGVRKRVVFWGLPDYYRPLTGLEKALQVGMG
                     VLTILPLFIGFGLFLYSLDVHGYLYLPLPILGFLGLVLSVFYYWKLRLDNRDGVLNEA
                     GAEVYYLWTSFENMLREIARLDKAELESIVVWNRLLVYATLFGYADKVSHLMKVHQIQ
                     VENPDINLYVAYGWHSMFYHSSAQMSHYASVANTASTYSVSSGSGSSGGGFSGGGGGG
                     SIGAF"
     gene            11289..12854
                     /locus_tag="VVO18_001490"
     CDS             11289..12854
                     /locus_tag="VVO18_001490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding
                     protein/permease"
                     /protein_id="HEU5586618.1"
                     /translation="MRKIYLSIFTSLLLMLGLVNVAQADEYLRIGMEAAYAPFNWTQD
                     DDSNGAVKIDGTNQYANGYDVQIAKKIAKDLGKEPLVVKTKWEGLVPALTSGKIDMII
                     AGMSPTAERKQEIAFSSSYYTSEPVLLVKKDSAYVSAKSLDDFNGAKITSQQGVYLYD
                     LIAQIPGAKKETAMGDFAQMRQALEAGVIDAYVSERPEALTAEAANSKFKMIQVEPGF
                     KTGEEDTAIAIGLRKNDNRISQINASIETISKDDQVALMDRMIKEQPAEATTTEETSS
                     SFFSQVAKILSENWQQLLRGAGITLLISIVGTIIGLIIGLAIGVFRTAPLSENKAIYG
                     LQKLVGWVLNVYIEIFRGTPMIVQSMVIYYGTAQAFGINLDRTLAAIFIVSINTGAYM
                     TEIVRGGILAVDKGQFEAATALGMTHNQTMRKIVLPQVVRNILPATGNEFVINIKDTS
                     VLNVISVVELYFSGNTVATQTYQYFQTFTIIAVIYFVLTFTVTRILRFIERRMDMDTY
                     TTGANQMQTEDLK"
     gene            12854..13594
                     /locus_tag="VVO18_001491"
     CDS             12854..13594
                     /locus_tag="VVO18_001491"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000189492.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="HEU5586619.1"
                     /translation="MTQAILEIKHLKKSYGQNEVLKDISLTVHKGEVISIIGSSGSGK
                     STFLRSINLLETPTDGQILYHGQNVLEKGYDLTQYREKLGMVFQSFNLFENLNVLENT
                     IVAQTTVLKRERTEAEKIAKENLEKVGMGERYWQAKPKQLSGGQKQRVAIARALSMNP
                     DAILFDEPTSALDPEMVGEVLKIMQDLAQEGLTMIVVTHEMEFARDVSHRVIFMDKGV
                     IAEEGKPEDLFTNPKEDRTKEFLQRYLK"
     gene            complement(13703..13918)
                     /locus_tag="VVO18_001492"
     CDS             complement(13703..13918)
                     /locus_tag="VVO18_001492"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002893653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586620.1"
                     /translation="MAKSNFEKVESVVGWVRDKKITGYRISKETNAREMSIIALAQGR
                     AKVKNISFETALGLIDFYEKNYEKFED"
     gene            complement(14789..16039)
                     /gene="ilvA"
                     /locus_tag="VVO18_001493"
     CDS             complement(14789..16039)
                     /gene="ilvA"
                     /locus_tag="VVO18_001493"
                     /EC_number="4.3.1.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006151817.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="threonine ammonia-lyase IlvA"
                     /protein_id="HEU5586621.1"
                     /translation="MLSSKDIIKAHKVLNGVVVNTPLDYDHYLSEKYGAKIYLKKENA
                     QRVRSFKIRGAYYAISQLSKEERERGVVCASAGNHAQGVAYTCNEMKIPATIFMPITT
                     PQQKIGQVRFFGGDFVTIKLVGDTFDASAKAAQEFTVSENRTFIDPFDDAHVQAGQGT
                     VAYEILEEARKESIDFDAVLVPVGGGGLIAGVSTYIKETSPEIEVIGVEANGARSMKA
                     AFEAGGPVKLKEIDKFADGIAVQKVGQLTYEATRQHIQTLVGVDEGLISETLIDLYSK
                     QGIVAEPAGAASIASLEVLAEYIKGKTICCIISGGNNDINRMPEMEERALIYDGIKHY
                     FVVNFPQRPGALREFVNDILGPNDDITRFEYIKRASKGTGPVLIGIALADKHDYAGLI
                     RRMEGFDPAYINLNGNETLYNMLV"
     gene            complement(16089..>16249)
                     /locus_tag="VVO18_001494"
     CDS             complement(16089..>16249)
                     /locus_tag="VVO18_001494"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001027901.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ketol-acid reductoisomerase"
                     /protein_id="HEU5586622.1"
                     /translation="NYFIFHRNDSEESLVEWLYDWISTNRYELPKEFSIRMAHKYHES
                     VTEIFGDE"
BASE COUNT         5106 a         3465 c         2923 g         4755 t
ORIGIN      
        1 ctaaacaaat acattgaaaa aagaattaca gataaaatta ccattttaaa tatattattg
       61 gatattcggt ctattgaact agatgaactg tctactttaa cttcattaca atctaaaagt
      121 ctcctaagca ttttgcagga attacaagaa acattcgagg aagagttgac atttaattta
      181 gatacgcaac aagttcaatt aatcgaacac cattctcatc aaacgaatta ttacttccat
      241 cagctttata accaatcaac tattttaaaa atactccgct tctttctact acaaggtaat
      301 caaagcttta acgaatttac acaaaaagag tatatttcca tcgcaacagg ctaccgcgta
      361 cgacaaaagt gtggcttgtt actacgttca gtaggtttgg accttgtgaa aaatcaagta
      421 gttggtcctg aatatcgcat tcgtttttta attgcactcc tccagtttca ttttggtatt
      481 gagatttatg atttgaatga tggaagtatg gattgggtca cacatatgat tgtgcagtct
      541 aattctcaac tcagtcatga actgttagaa atcacacctg acgagtatgt tcattttagc
      601 atactagtgg cactcacttg gaaacgtcgg gaatttccac ttgagttccc tgagtccaaa
      661 gagtttgaaa aattaaaaaa cctctttatg tatccgattt tgatggaaca ttgccaaact
      721 tacttagagc cacatgccaa catgactttt actcaggaag aactggatta tatctttttg
      781 gtttattgtt ctgctaattc ttcgttttcc aaggacaaat ggaatcaaga aaaaaagact
      841 catactattc aactgattct tcagcataca agaggaaagc atctactatc caagttcaag
      901 aatatcttag gaaatgacat ttcgaattct ctttcttttt taacagcact gactttctta
      961 acaagaacgt ttttgtttgg tttacaaaat ctagttccct attataatta ttacgaacat
     1021 tatgggattg aaagcgacaa gccactgtat catatttcga aagcaattgt tcaagagtgg
     1081 atgactgagc agaagattga aggagttatc gaccagcatc ggctgtacct tttctcactc
     1141 tacttgacag aaaccatctt ttcctcacta cctgctatcc cgatttttat cattttaaat
     1201 aatcaagcag atgtaaactt aataaagtcc attattttac ggaattttac tgacaaagtt
     1261 gcctctgtta caggatacaa tattctaatt agtcctcctc cttcagagga gcatttgaca
     1321 gagccattga ttattattac aacgaaagaa tacctgcctt acgttaaaaa gcagtatccc
     1381 aaagggaaac atcacttttt gacgattgcc ttagatttgc atgttagcca acagcgtctc
     1441 atctatcaga caattgtaga tatccgaaaa gaggcttttg acaaacgggt cgcaatgatt
     1501 gctaaaaagg ctcactattt gttataagtt catcgtactg tctacacaca aaaaggggct
     1561 tcctaagcca tctctattct tatccccata tttcccagtt ttgggtaaat ctgaacagaa
     1621 aaacacttct gctctctagt ttctgctagt gaacaaaagt gttttttctg gctctataat
     1681 ttctgtagtg ggtaaatccc actgtggaga ttatagggct ttttgagtat caaaaaagtc
     1741 ccataagact tataatgaaa agcgcctaaa caactcatta gaaagtatct tatggaacac
     1801 atcaatcata ccacattact catcggaata aaagacaaaa acatcacctt aaataaagcc
     1861 attcagcacg atacccatat cgaagtcttc gctacacttg attatcaccc acctaaatgt
     1921 aaacactgta aaggaaaaca aatcaaatac gacttccaaa agccttctaa aatccctttt
     1981 atcgagattg gtggtttccc tagcctcatt catttgaaaa agagacgatt tcaatgcaag
     2041 tcctgtcgga aagtcactgt agctgaaaca actctcgttc agaaaaattg ccaaatctcg
     2101 gaaatggtga gacagaaaat tgcccaactc ctactcaaca gagaggctct tacacatatc
     2161 gcttctaaat tagccatctc tacctctacc tctaccgtct atcgtaagct caagcaattt
     2221 catttccaag aggattacac cactttgcct gaaatcctct cctgggatga attctcctac
     2281 cagaagggga aattggcttt cattgctcag gatttcaaca ctaagaaaat catgaccatt
     2341 cttgataaca gacgtcaaac aaccatccga aatcatttct tcaagtactc gaaagaagct
     2401 agaaaaaaag ttaaagtcgt cactgttgat atgtctggaa gttatatccc tctcattaag
     2461 aaattatttc ccaatgctaa aattgttctc gatcgtttcc acattgtcca acacatgagc
     2521 agggctctta atcagactag aatcaacatc atgaagcaat ttgatgataa atctctggaa
     2581 tacagagctc ttaaatatta ctggaaattt atcctaaaag atagtcggaa actctctctt
     2641 aagcctttct atgctagaac tttcagagag accttaactc ctagggagtg tctgaagaaa
     2701 atctttactc tagtacctga acttaaagat tactatgacc tgtatcaact actcctattt
     2761 catctacaag agaagaatac tgaccagttt tggggcttaa ttcaagacac gttacctcat
     2821 ctcaaccgca cctttaaaac cactttgagc acatttattt gctataaaaa ctacatcact
     2881 aacgccattg aattgcctta ttctaacgct aaacttgagg ccactaacaa actcatcaaa
     2941 gacatcaagc gcaatgcctt tggttttcgg aactttgaaa acttcaaaaa acggattttc
     3001 atcgctctga acatcaaaaa agaaaggaca aaatttgtcc tttctcgagc ttagcttttc
     3061 ttcaacccac tacagttgac aaagagccct ttttattatt caagaacttg attagctcaa
     3121 tgcatccaag gcgtcatcca ttgaaagaac ttcgtggaag acacgttgtg tcaattcagt
     3181 tttttgttct ggagtgaggt atttagtgtt tacacagtat ccagagatac gtacgataac
     3241 gtcttcgcct gacatgattt tttcgtaaac atcgttcaag tccataacgt tcaagttaac
     3301 gtgttgtcca ccgttttcga agtaaccatc aaggattgtt accaagttat caacttgttc
     3361 atcacgagtc ttaccaagag cgcgaggtga tacttgtgta gtcaatgaga taccgtcagc
     3421 tgcataacta aagtcaaggc tagaaagtga gttcaagttt tgcaaccaac cacctttagc
     3481 tttgttagat gggttagcac ctggtgagaa gaattcaagt ttagacaagt tcacagaacc
     3541 atcttcgttg aggtatacac ctttgtgaac tggtgagtta ccagtttgtt tagagtaagc
     3601 aacgttagat gtgattgtca aaagtgatac tgtagcttct gcgtctttgt atagtttgtg
     3661 gctacgtaga cgagttgtgt aagcttcgat caaccattct gccaattcgt ttgaacgtgg
     3721 gtcatcttca ccccagcgtg ggtagtcacc gattgtttcg taatcgtaga tgtagccatc
     3781 ttcatcacgg attggtttaa ctgtagcgta tttaatcgct gacaatgtat caacagtgtt
     3841 agcaaatcca caaataccga atcccatgtt ggcacgttgt ttagttggca agaaggccat
     3901 ttgaacagct tcgtagttgt acttatcagt catgtagtgg atgatgttca aggcatctac
     3961 gtaagtgtca gtcaaccagt caagagattt ttcaaagttc gctttaactg attcgaattc
     4021 aagaacttcg tcacgaatag gatcgatgtc aaatactttg tagtctttgt gaacatcgtc
     4081 gtaaccacca ttcaaaccag taagaagggc tttaagaacg tttacacgag caccgaagta
     4141 ctggatgttg tggcgttgtt cttcattttc tggatcaagt ggagacacac agcatgagat
     4201 acagctcatt tcaccatatc cgtctttagc cattgttgtt acaccttcgt attggataga
     4261 agagtgtttg tggctcatgt gcatacagta gcgacggaag ttgtatggca atttgtcagt
     4321 ccaaagaact gtcaagtttg gctctggaga gttaccgatg ttgtcaagag tgttcaagaa
     4381 acggtagtcc atcttagtaa cacggtgacg accgtcgtta cccataccag ccatagaagt
     4441 tgtgataaag gttgggtcac ctgagtacaa ttggtcataa gcttttgtac gagcaaattt
     4501 aactgtacga agtttcataa cgaaatcatc aacgaattct tggatttctg attcagtaaa
     4561 tgtaccacga gcaaggtcac gttctgcaaa gatgtccaat acgattggta cacgacctag
     4621 agatgtagca gcaccgttaa tcacacggca gacagccatg aaagcaatgt taacccattg
     4681 gattgcttct ttcacgttca tcgctggttt gcgaacatca accccgtaaa ggtcacccag
     4741 gcgaacaact tgttgcaatg cttggtattg aaggtttact tcttcacgaa gacggattgt
     4801 ttcttcatcg atttctttga ttgcattcca gtcgtttact ttttcttgca tcaagtagtc
     4861 tgcaccgtaa agagcaagac gtgcgtaaac accgatgata cgtccgcgtg agtatgcatc
     4921 tggaagacca gttacagtgt gtgcatgacg agcgcgacga atatttgaag tgtaggcacg
     4981 gaaaataccg tcgttaactg ttgttacata tttagtgaag atttcgtgaa cagctgggtc
     5041 tggttcgtat ccattttctt ttaaagtagt ttcagccata cggataccac cttttggcat
     5101 gaagttcaat ttgaagagtt catcattttg gataccaaag ataacttcat tttctttgtc
     5161 gataaatcca gcagggatat cagcgataga tgttggacga gtgtccattg ggaaacgagt
     5221 ttcttcgtag tgtgctttag tttcttctac aattttcttg atgtgaagtg aacgctctgt
     5281 tggtcctgca aggaagcttt cgtctccatc ataaggtgtg tagttagctt gtacaaagcg
     5341 tgatacactt gctttttctt tccaatctac gcctttgaag ccttcccaag ctttgtcaaa
     5401 aatatcttgt gcttcaacaa ctgtcttaac aaccatatta atgtcctctt ttttctagta
     5461 acagtcatct gttacattca tgagacaagt ataccatata gtaaccgatt tcaacaagtg
     5521 aaaaatccct atttttacac tttcttttct aaaacagtct atattttatt tcaaactgta
     5581 ttatattttt gaaaaaataa agtccttttt tctttttttc agaaaaaagg gtataataaa
     5641 agaaaataag cagtaacact caatggaaat cgaaaagcaa actaggaagc tagccgcaga
     5701 tttctcaaaa cactgttttg aggttgcaga tagagctgac gtggtttgaa gagattttcg
     5761 aagagtataa aaaggtgcta ggcatgttga tttttccttt gttaaatgat ttgtcaagaa
     5821 aaatcatcca tattgacatg gatgcctttt ttgctgcggt ggaaatcaag gataatccta
     5881 aactcagagg aaaacctgtc attattggaa gcgaccctcg gcaaacaggt ggacggggag
     5941 tcgtttctac ctgtagctat gaggctcgag cttttggtgt ccattctgcc atgagttcca
     6001 aggaagctta tgaacgttgt ccccaggccg tctttatctc aggaaattat gagaaataca
     6061 aagctgtggg actccagatt cgagctattt ttaagcgcta tacagatttg attgaaccca
     6121 tgagcattga cgaagcctat ttggatgtga cagaaaataa actcggtatc aagtcagcgg
     6181 tcaaaattgc tcgcctcatt caaaaagata tctggcaaga actccatcta actgcttctg
     6241 ccggtatttc ctacaacaag ttcttagcta aaatggcgag tgattatcaa aaacctcatg
     6301 gtttgacagt gattctacct gaacaggctg agaattttct caaacaaatg gatatttcca
     6361 aatttcatgg agtaggaaaa aagacagtag aacgtcttca tcaaatgggc gtttttactg
     6421 gtgctgattt acttgaagtt cctgaggtga ccctaataga ccgttttggt agactaggct
     6481 atgatctgta tcgaaaggct cgtggcattc acaactctcc agtcaaatcc aatcgcatcc
     6541 gtaaatcaat cggcaaggag aaaacctacg ggaagattct ccgtgctgag gaagatatca
     6601 aaaaagagct gactattcta tcagaaaaag tcgctctcaa tctacatcaa caagaaaaag
     6661 ctggaaaaat tgtcattttg aaaatccgct acgaggactt ttcaactctt accaaacgaa
     6721 aaagtcttgc tcaaaaaaca caagatgcta gtcagataag ccaaatagcc ctgcaactct
     6781 atgaagaatt aagcgagaaa gaaagaggtg tccgcctatt ggggattacc ctgactggat
     6841 tttaaagctc aatgaaaatc aaagagcaaa ctaggaagct agtcgcaggc tgctcaaaac
     6901 actgttttga ggttgcagat aaagctgacg cggtttgaag aaattttcta agagtataaa
     6961 accttgaaga gttgcccctt caaggttttt cttatacaaa taaacggaca aaactgtaaa
     7021 gtagcaaaac actaccaagc acgatacggt atttaccaaa aagggtgaag tcgtgttttt
     7081 tcacatagct ggtcaagaag cgaatagcca ccatgctgac cgcaaaagct actcccatcg
     7141 cgaccaagag caaaaacaat tgcccaaagc tcaagagttc tccggctttc acaaatttga
     7201 aaatctttaa ggcactagct ccaaacataa cgggaatccc aagatagaag gtaaattctg
     7261 tcacaactga acgactggtt ccatttaaca aaccaccgac aatcgttgca cctgaacggc
     7321 tagtccctgg taaaagagca agaacttgga agagtccgat atagaaagcg gtcgtataag
     7381 gaagcttgtc caactctgtt acacttggct cgatagcacg cgctttattg cgcttttcca
     7441 aatagatgaa ggcaaccccg tagataatca acatgagagc aactgaaacc atgttatgga
     7501 agtgggtatc aaaccaatca tcaaatttaa agacaccaag taaaggcaaa gtggcaatca
     7561 agaccttcaa ccatagtctc caagtcttac gaacttcctg tttgtcctta gtcggtttaa
     7621 aaggattgag cttgttaaaa taaatcacta taactgctaa aatagcacca agctgaatca
     7681 cgacattaaa catggacata aaggcttcat tttgattttg gtattggata aactcctctg
     7741 ctaaaatcaa gtgacctgta ctggaaatcg gcaaccattc cgtaattcct tcaacaatcc
     7801 cgaagaagat agattttaaa atttcaataa gatacatata tttctcctta tattatattt
     7861 aacgcagtta gctactgcca aagcccaagt ggtatacttg gaataagcca ctgtggatta
     7921 gttcatttcc tccaatcgct tgacgatttc cgaaagggtc taaccacagc tttttgtttc
     7981 aattggtaat gagtttgata acgcatagac gttttatctc gtctaaggta acaaggcaaa
     8041 aagttcgtgg ataaccaagt agacttgaaa tactatatct ggaggtactc ccatgcttta
     8101 tgtgggcatt gatgtcgcta aaaataaaca cgatgttaca gccttgaatg ttcgaggaaa
     8161 actgttctta aaccactcac tttttcaaat aataaagctg gttttgaact cttagatctg
     8221 tcttttcgac agctcaacca agactgtctc atcgctctta aacttctttc tgaccccaat
     8281 cgtgaacaat ttcaacacga taatcggcaa gtagaactaa aaatactggc tagacatatt
     8341 catcgtctca agaaaaaaca gtctgattgg aaagtacaat acactcgttg tcttgatatc
     8401 atctttcctg agttggataa aatcgttgga aagcattcag aatataccta ccaactcttg
     8461 acacgctacc ctaatcctca gaaaaggctt gaggcaggat ttgataagct gatagaaatt
     8521 aagcgattga ccgcttctaa aattcaggat atcctctcag tcgcacctcg ttctatcgga
     8581 acaacatctc ctgctcgtga attcgaaatc atcgaaatca tcaaacatta caagaggctc
     8641 attgacaagg cggaaacatg tgtcaatgac ttgatggctg agttcaactc ggtcatcacg
     8701 acggttactg ggattggggg tcgtttaggg gcggtcattt tagccgagat tcgaaatatt
     8761 catgcctttg ataatcctgc tcaattacaa gctttcgctg gactggattc ttctatttat
     8821 cagtcaggtc agattgattt agctggaaga atgatcaaac ggggttcccc tcatctgcgg
     8881 tgggcactca tacaagctgc caaagcatgc gctcgctttt cacctgcttt taaggcctat
     8941 cttaagacta agttagaata aggaaaacat tacaatgtag ccatcatcca ccttgcaaaa
     9001 aaacttatcc gaaccctgtt ttatatccta aaaaagagct gccatttgac gaacaaaaag
     9061 tgatgtaatt tctgaaatta acacaggatt acctttgaaa aaatggactt tttcaagggc
     9121 tttttgccgt gctctaaaat catcgccaaa tcatcaaatt gaaataagaa atagtttaga
     9181 taaaactatt gacttttctt atagtttgtc tttcttctat cttccattat atcatacttt
     9241 ttcagtctat ggtagctctc tttaaaaggc tccgatactg ccgccacctc cgcctccaga
     9301 gaagccacca ccagaacttc cacttccaga agatacagag taggtacttg ctgtatttgc
     9361 gacactagca taatggctca tttgcgcgct tgaatgataa aacatactgt gccagccata
     9421 agctacatag agattgatat ctggattttc aacttgaatc tgatgaacct tcatcaaatg
     9481 actaaccttg tccgcatagc caaataaggt tgcatagacc aagagacgat tccaaacaac
     9541 aatactttcc aattcagcct tatccagtcg tgcaatctca cgtaacatat tttcaaaact
     9601 ggtccagaga tagtagacct cagctcccgc ttcatttaga acaccatcac gattatctag
     9661 tcgaagcttc caataataga aaacagacaa aactaaccct agaaaaccaa gtattggcaa
     9721 agggaggtaa agatagccat gaacgtctaa actgtacaag aacaaaccaa atccgataaa
     9781 taggggcaag atagtcaaga cacccatacc cacttgcaaa gccttttcca aaccagttaa
     9841 aggacgatag taatctggga gtccccagaa gacaactcgc tttctcactc cttcttgcat
     9901 ctcttttaat actgcttcga aagaagattt gagctgaatc cctcttgctt gaatccgttt
     9961 ctcatcagca gctttagctc cgcgataaag gctgtcagat accttgtaat ccgcaaacaa
    10021 attggaaaga gtggcttctt ttttgcctga aaaggctaga tttagacagt ctctctcaaa
    10081 tcttgacaaa ccatcttctt tcaccaatct caagccaact gcatctcctt ctgaaataat
    10141 agaaacattc ccacggtcca tcacatctag caaggtagct tgaataagtt ggtcaaaagt
    10201 gaatttgcca gcccccttga ctaagggact cacttcctcc aaggaggtcg agtagacagc
    10261 ctctgataaa accataggct ctaattccat tggtggttca tagagacgat gatttttggc
    10321 atatttgact gaaggagtgg tctttcttct ataaataaaa tagaagcaga cactcaataa
    10381 caaggagata gaaaggatcg aagggaggac ccaagtaaca agttgtttac tctgatcttt
    10441 ttctctaaca atcgagtctt ctatcttatt aaactcttct aaacgattcc ctttcaatcc
    10501 ctgatcccta gcgctagcaa aatcggtccg aggccagtag gcatgcaact caactccacg
    10561 cttagccgga agattgtcta aacggatagt ataatcaagg ttactctttt caatcgttcc
    10621 ctctctaaaa agtttccctg tatggaaaaa gagtttttca gcccccttgt ctccccttac
    10681 atgaaattca aacttttcaa tagactctga actatctgtc agaggttgcc aatttaattc
    10741 agcgatatca tcataaagga aaagtaaatt ttttaagttc cagacgaggt caacttcaac
    10801 tatgtcgccc tcctgacctg gattatagac tctcacagta taaccatccg cttcttctgt
    10861 tacttcgcta gtcacatctg ctagttctgc accgtttttc gcggcctgaa cctttggatg
    10921 agggtcaatg tcaaacccgc taggcatctt accagcacgt ccaagtccca cgatttgtcc
    10981 cttaaagtcc tcctcaaact ggtaaactat cttctgtcta aactctgccg tattatctgc
    11041 atgaatatac aaatcccctt gataagagtt tatcttgaaa tcaatggcaa aaacagagag
    11101 tggaagaagg caaaacaagc ctaacaccag taagaaaaaa gtttttttca tcaactaagc
    11161 ccccttttta tctttcttat cattatagca ttttttcgta agtaaaggct tacttatgtt
    11221 gaaaaattac gcatttttcg ataaaatagg agacagttat tttttaatag atcagaatag
    11281 gagaaatcat gagaaaaata tacttatcta ttttcacaag tctcttgctg atgctaggac
    11341 ttgtcaatgt tgctcaagcc gatgaatatt tacgcatcgg gatggaagca gcatatgctc
    11401 cctttaactg gacccaggat gatgatagca acggagctgt caaaatcgat gggaccaatc
    11461 agtatgccaa cggatacgat gttcaaatcg ccaagaaaat cgctaaggac ttaggtaaag
    11521 aacctttggt tgttaaaacc aagtgggaag gtctagtccc tgcccttact tctggtaaga
    11581 ttgacatgat tatcgcaggt atgagtccaa ctgcagaacg caaacaagaa attgcctttt
    11641 cgagcagtta ctacactagc gaaccagttt tgcttgtcaa aaaagattct gcctacgtaa
    11701 gtgctaaatc tttggatgac tttaacggtg caaaaatcac ttctcaacaa ggggtctacc
    11761 tctacgactt gattgcacaa atcccaggtg ctaaaaaaga aacagccatg ggagacttcg
    11821 ctcaaatgcg ccaagctctt gaggctggtg tcattgatgc ttatgtttct gaacgtccag
    11881 aagcactgac tgctgaagct gcgaactcta agttcaagat gattcaagta gaacctggtt
    11941 tcaaaactgg ggaagaagat acagctatcg ctatcgggct tcgtaaaaat gacaatcgta
    12001 ttagccaaat caatgccagc attgaaacca tttcaaaaga tgaccaagtt gccttgatgg
    12061 atcgtatgat caaggaacaa cctgccgaag ctacaacaac tgaagagact agcagtagtt
    12121 tctttagcca agtcgctaaa attctttctg aaaactggca acaactcttg cgtggtgctg
    12181 gtatcactct tttaatctct atcgtcggaa ccatcatagg tctcattatt ggacttgcca
    12241 ttggtgtctt ccgtactgct cctctctctg aaaacaaagc catttatggc cttcaaaaac
    12301 tagtcggctg ggttctcaat gtctacattg aaattttccg tggtacgcca atgattgttc
    12361 aatcgatggt tatctactat ggaactgccc aagctttcgg gatcaacctt gaccgtacac
    12421 tagctgctat cttcatcgtt tcaatcaata ccggtgccta catgactgaa atcgtccgtg
    12481 gtggtatcct agcagttgac aagggacaat ttgaagctgc gactgctctt ggtatgaccc
    12541 ataaccagac catgcgtaag attgtcctac ctcaggtagt ccgtaacatc ctacctgcaa
    12601 ctggtaatga atttgtcatc aatatcaaag atacatctgt attgaacgtt atctctgttg
    12661 tcgaacttta tttctcagga aataccgtgg caacacaaac ctatcaatac ttccagacat
    12721 ttacaatcat cgccgtgatt tactttgtcc tcaccttcac cgtaacacgt atcctacgct
    12781 ttatcgagcg cagaatggac atggatacct acactacagg tgctaaccaa atgcaaacgg
    12841 aggatttgaa ataatgacac aagcaatcct tgaaattaaa cacctcaaaa aatcctatgg
    12901 acaaaacgaa gtgctaaaag acatttcact cactgtccac aagggagagg tcatctctat
    12961 catcggaagc tctggaagcg gaaaatcgac cttcctacgc tccattaacc tacttgaaac
    13021 accaactgat ggacaaatcc tttatcatgg acaaaacgtc ctcgaaaaag gctatgacct
    13081 cacgcaatac cgtgaaaagt tggggatggt tttccaatcc tttaacctct ttgaaaatct
    13141 caatgttctt gaaaacacaa tcgtcgctca gacaactgtc ctaaaacgcg aacgcacaga
    13201 agctgaaaag attgccaaag aaaacctgga aaaggtcggc atgggagaac gctactggca
    13261 agccaaacca aaacaactct caggtggtca aaaacaacgt gtggccatcg ctcgtgccct
    13321 ctccatgaat ccggacgcca ttctctttga tgaaccaaca tcagctctcg atccagaaat
    13381 ggttggagaa gtcctcaaaa tcatgcagga cctggctcag gaaggcttga ccatgattgt
    13441 cgtaacccat gaaatggaat ttgcccgtga tgtctctcac cgtgttatct ttatggataa
    13501 gggcgtgatc gctgaagaag gtaaaccaga agacctcttc accaatccta aagaagaccg
    13561 aacaaaagag ttccttcaac gctatctcaa ataaaaagaa aaggctgcat caaccgtgca
    13621 gtctttttgc tgtcctcaaa atgaaaaggc agattctcta tctctactac ttgaaggtca
    13681 agaatccgcc gttatccaaa gattaatctt caaatttttc ataatttttt tcatagaaat
    13741 caattaggcc tagggctgtt tcaaatgaaa tattttttac ttttgcacga ccctgcgcca
    13801 gagcaatgat agacatttca cgcgcattcg tttctttaga gatacggtag cctgtgattt
    13861 tcttatcacg aacccagcca acaactgatt ctactttttc aaagtttgac ttagccatgt
    13921 ttttctccca ttttcttctt tataatattt aattgtatac gtttttacta cttttgtcaa
    13981 taaaaaaaac atatattcaa cgaaaataat tagttcagaa ttttcttact tcctttttaa
    14041 atccgataat atataggttt cgctagcctc tacaccataa atatttgcta ataaaaatac
    14101 tgtattatta ccctcttaag gtgcgaaatt attcaagttc ttaaaaaatg cttctctatt
    14161 tccgtaagat agcttatttc ttcgatttaa gaactgaaga tgatagttct aacctttaga
    14221 aatccaagcc ttcactagct caaaaactcc tatctttctt cctcaataaa tcatctgaga
    14281 gataggtatt ccttatgtcc ttcaaattca tcactccttt ggatattgag gtgctagcct
    14341 agaagcagac acccgattat ctaaaccatc cttaataaag atgacaagac agataagctc
    14401 agttaattac ttatatatct ttttaatatg gtatatttgt caacaaaaag aaatcaaatc
    14461 ataccttata ctcaatgaaa atcaaagagc aaactaggaa gctagccgca agttgctcaa
    14521 aacactgttt tgaggttgca gatagagcta acgtggtttg aagagatttt cgaagagtat
    14581 taaagacagt gtgactatgc ttgtcaatag ataggaaatc aaaatgaagg atggaaatct
    14641 gagccaaaca tcataagtgc tataatgaac agaagtaaga attgcacgat aagttttcta
    14701 aaaccatagg aatcgtcccc tttcttcatc ttcattatag cacatataca tcagttgtac
    14761 aaataatatg atattttttt attagtcctc agacaagcat attataaagc gtttcattac
    14821 catttaagtt aatataagct ggatcaaaac cttccattct acgaatcaaa cctgcataat
    14881 catgcttatc tgctaaagcg atcccaatta atactgggcc tgttcccttg ctagctcgtt
    14941 tgatatactc aaaacgtgtg atatcatcat ttggccccag gatatcattt acaaactcac
    15001 gcaaagctcc tggacgttgt gggaaattga ccacaaagta atgtttgata ccatcataaa
    15061 tcaaggcacg ctcttccatt tctggcatac ggttgatatc attatttcct ccagaaatga
    15121 tacaacaaat ggttttcccc ttaatatatt cagctaaaac ctctaaagag gcgatactag
    15181 ctgctccagc aggttctgcg actatccctt gcttagagta aaggtcaatc aaggtttcag
    15241 aaatcaatcc ctcatcgaca cctaccaaag tttgaatatg ttgacgagtt gcttcatagg
    15301 tcaactgacc taccttttgc acagcaatcc catccgcaaa tttatcaatt tccttgagtt
    15361 tgactggacc tccagcctca aaggcagctt tcatggaacg cgctccattc gcctctactc
    15421 cgataacctc aatctctgga cttgtttcct tgatataggt agaaaccccg gcaatgagac
    15481 cgccaccacc aacaggaacc aagacagcat caaaatcaat cgattctttt cgagcttctt
    15541 ctaaaatctc ataagcaact gttccttgac ctgcttgaac atgagcatca tcaaaaggat
    15601 caataaaggt acgattttca gagactgtaa attcttgagc tgctttggct gaggcatcaa
    15661 aggtatctcc aactagttta atagttacaa aatccccacc aaaaaagcga acctgaccaa
    15721 tcttttgttg tggcgtagta atgggcataa agatagtagc aggaattttc atttcattac
    15781 aagtataggc tactccctgc gcatgatttc ccgcagaagc gcaaactacc ccacgttcac
    15841 gttcttcctt gctgagctgg gaaatggcat aataggcacc acgaatttta aaggagcgaa
    15901 cacgctgggc attttctttt ttcaaataaa tcttagcacc atacttctcc gataaataat
    15961 gatcgtaatc cagtggagta ttcacaacca caccgttcaa gaccttgtga gccttgatta
    16021 tatcttttga acttaacata taaaacctct ttttctataa aaaacagtca ctaatgactg
    16081 ttttttagtt attcatctcc gaaaatttca gtaacacttt catggtattt atgagccata
    16141 cgaatcgaaa actctttagg aagttcataa cgatttgtgg aaatccaatc atataaccat
    16201 tctaccaaac tttcttcact atcattacga tggaagataa aatagttta
//
LOCUS       DAVHIZ010000041        16141 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.043, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000041 DAVHIZ010000000
VERSION     DAVHIZ010000041.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16141)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16141)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16141
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.043"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            81..944
                     /locus_tag="VVO18_001495"
     CDS             81..944
                     /locus_tag="VVO18_001495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001093609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5586623.1"
                     /translation="MNTLAEKFRLKRKELGLSQQTLAEGICEQSQISKIERGHFIPSA
                     DLLFKLSQRLEVPLDYFFNEQIEIKSNLSNFKQLSARLLDDRNYDNLEYIYRIEIERS
                     TFLTLEDRTYLEWIKAIIDFYQYDSKCEAISSLENILLKVSSNTLIYLKALNTLSNFY
                     SLVGREQEYEANYSHLMELYQTKNFEHQEFLFGYIRVRYNYSHYLVSKEKYNEAIQEA
                     LETIELCKQRQTSYQLAPLLILVGNAGAKFLDKEQVKNYYIEARELCKIYNNPLMLMK
                     IENYLKELDTV"
     gene            1250..1870
                     /locus_tag="VVO18_001496"
     CDS             1250..1870
                     /locus_tag="VVO18_001496"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000839915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586624.1"
                     /translation="MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFV
                     SGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLLINLLGAVLVLSDNLFIKNTLQQ
                     ELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
                     VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF"
     gene            1956..2399
                     /gene="tsaE"
                     /locus_tag="VVO18_001497"
     CDS             1956..2399
                     /gene="tsaE"
                     /locus_tag="VVO18_001497"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="HEU5586625.1"
                     /translation="MYTKNEEELQALGERLGHLLAKNDVLILIGELGAGKTTFTKGLA
                     KGLQISQMIKSPTYTIVREYEGRLPLYHLDVYRIEGDADSIDLDEFIFGGGVTVIEWG
                     NLLGDALPDAYLELEILKEADGRRLNFQAKGLRAEKLLEELQYGV"
     gene            2389..2907
                     /locus_tag="VVO18_001498"
     CDS             2389..2907
                     /locus_tag="VVO18_001498"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586626.1"
                     /translation="MEYELLIREAEPKDAAELVAFLNRVSLETDFTSLDGDGILLTSE
                     EMEIFLNKQASSDNQITLLAFLNGKIAGIVNITADQRKRVRHIGDLFIVIGKRYWNNG
                     LGSLLLEEAIEWAQASGILRRLQLTVQTRNQAAVHLYQKHGFVIEGSQERGAYIEEGK
                     FIDVYLMGKLID"
     gene            2915..3931
                     /locus_tag="VVO18_001499"
     CDS             2915..3931
                     /locus_tag="VVO18_001499"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000239264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LCP family protein"
                     /protein_id="HEU5586627.1"
                     /translation="MVKKIIGMVLALLSVTVVGVGVFAYTIYQQGTETLAKTYKKIGE
                     ETKVIEATEPLTILLMGVDTGNAERTETWVGRSDSMILMTVNPKTKKTTMMSLERDIL
                     TRIESGNGQAHEAKLNSAYADGGAELAIETIQKMMNIHIDRYVMVNMRGLQKLVDAVG
                     GITVNNILGFPISISDQEEFNTISIGVGEQHIGGEEALVYARMRYQDPEGDYGRQKRQ
                     REVIQKVMEKALSLNSVGHYQEILKALSDNMQTNIDLSAKSIPNLLGYKDSFKTIETQ
                     QLQGEGEILQGVSYQIVSRAHMLEMQNILRRSLGQEEVTQLETNAVLFEDLFGRAPVG
                     DEDN"
     gene            4016..5272
                     /locus_tag="VVO18_001500"
     CDS             4016..5272
                     /locus_tag="VVO18_001500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642700.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="competence/damage-inducible protein A"
                     /protein_id="HEU5586628.1"
                     /translation="MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGD
                     NEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQTLAKFLGKALVFDPQAQEKLDIF
                     FALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
                     VLNQLLPKLMTGNKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLR
                     LSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQG
                     KTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVS
                     EFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIG
                     GRSRADVRHIAVMHAFNLVRKALLSD"
     gene            5327..6493
                     /gene="recA"
                     /locus_tag="VVO18_001501"
     CDS             5327..6493
                     /gene="recA"
                     /locus_tag="VVO18_001501"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397020.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase RecA"
                     /protein_id="HEU5586629.1"
                     /translation="MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGE
                     RAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGI
                     AAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVA
                     ALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGN
                     PETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAV
                     VEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFD
                     EIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE"
     gene            6800..8170
                     /locus_tag="VVO18_001502"
     CDS             6800..8170
                     /locus_tag="VVO18_001502"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036275.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MATE family efflux transporter"
                     /protein_id="HEU5586630.1"
                     /translation="MNKKRTVDLIHGPILPSLLSFTFPILLSNIFQQLYNTADVLIVG
                     RFLGQESLAAVGATTAIFDLIVGFTLGVGNGMGIVIARYYGARNFTKIKEAVAATWIL
                     GALLSILVMLLGFLGLYPLLQYLDTPAEILPQSYQYISMIVTCVGVSFAYNLFAGLLR
                     SIGDSLAALGFLIFSALVNVVLDLYFITQLHLGVQSAGLATIISQGLSAVLCFYYIRK
                     SVPELLPQFKHFKWDKSLYADLLEQGLAMGLMSSIVSIGSVILQFSVNTFGAVIISAQ
                     TAARRIMTFALLPMTAISASMTTFASQNLGAKRPDRIVQGLRIGSRLSISWAVFVCIF
                     LFFASPALVSFLASSTDGYLIENGSLYLQISSTFYPILSLLLIYRNCLQGLGQKILPL
                     VSSFIELIGKIVFVVLIIPWAGYKGVILCEPLIWVAMTVQLYFSLFRHPLIKEGKAIL
                     ATKVQS"
     gene            8546..9502
                     /gene="lytA"
                     /locus_tag="VVO18_001503"
     CDS             8546..9502
                     /gene="lytA"
                     /locus_tag="VVO18_001503"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000405235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase LytA"
                     /protein_id="HEU5586631.1"
                     /translation="MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWR
                     KDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDY
                     RLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGIS
                     REQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLAD
                     RWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEG
                     AMVSNAFIQSADGTGWYYLKPDGTLADKPEFTVEPDGLITVK"
     gene            9861..10022
                     /locus_tag="VVO18_001504"
     CDS             9861..10022
                     /locus_tag="VVO18_001504"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000289348.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5586632.1"
                     /translation="MYVINVCDVGKRIKELRISSNLTQDKIAEYLSLNQSMIAKMEKG
                     ERNITNGFK"
     gene            10009..10215
                     /locus_tag="VVO18_001505"
     CDS             10009..10215
                     /locus_tag="VVO18_001505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000366086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586633.1"
                     /translation="MDLSNKAPNLRKKLGADGESPIDIFKLVQKIENLTLVFYGLGKN
                     ISGVCYKGTQFSLIAVNSDMSLGR"
     gene            10261..10620
                     /locus_tag="VVO18_001506"
     CDS             10261..10620
                     /locus_tag="VVO18_001506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749821.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586634.1"
                     /translation="MKKSSVSLILIGEGDETERKADQFASYFLIFPSSLYRMVEEIRE
                     NANRTHLEVEDIIKLGQFYGISHKAMLYRLRNDGYLDAEEIKNMDISVIETASRLGYD
                     TSLYRPLSESKKETVLG"
     gene            10749..11174
                     /locus_tag="VVO18_001507"
     CDS             10749..11174
                     /locus_tag="VVO18_001507"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000204068.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586635.1"
                     /translation="MTSRVFIDADCISVFLWVGTEHLLEKLYSGKIVIPQEVYDEINI
                     PTIPHLKSRIDQLVAKGSAEIVSIDIGTEEYALYRDLTRNHDSNKIIGKGEAASISLA
                     KKHNGILGSNNLRDVKSYVEEFSLEHMTTGDILIEAFKV"
     gene            11582..12376
                     /locus_tag="VVO18_001508"
     CDS             11582..12376
                     /locus_tag="VVO18_001508"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101215.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586636.1"
                     /translation="MNVKKIMSIFQSFYVDVSIEELTLTLPISFVKRFEYTQMTFHKE
                     SFLLIKEKRRGSLSSFVTQARTMGEKANMDVVLVFSKLSDSEKKQLLQARVPFVDFKG
                     NLFFPPLGLVLNANDTEVPKELTPSEQLTWIAFLLTKGQKVVDVDLLSQVTGLPNSTI
                     YRCLRTFKALYWLNKQNKLYTYTVSKKELFLKSVSCLFNPIKKRILLPDGDIKQIKSV
                     SNLLYGGAYALSHSTFLAETDENTSYVIWQRKFNQLSLPLSQYVLK"
     gene            12380..12577
                     /locus_tag="VVO18_001509"
     CDS             12380..12577
                     /locus_tag="VVO18_001509"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000890145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586637.1"
                     /translation="MLEIWKYRPFVSEFWNDFKNNHDKQFVDPISLYLTLKDDDDPRI
                     EEESEALENMILQYLGEDDAS"
     gene            12567..13118
                     /locus_tag="VVO18_001510"
     CDS             12567..13118
                     /locus_tag="VVO18_001510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001111259.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586638.1"
                     /translation="MPANTKVIFQEMFADFQNYYVLIGGTATSIVLDSQGFKSRTTKD
                     YDMVIIDEVKNKEFYTTLNHFLELGEYQGSQKDEKAQLFRFTTTNLEFPSMIELFSIL
                     PEYPLKKDGREISLYFDQDASLSALLLDEDYYNILVHVKETIQGYSVLSNCGLYSSTI
                     SSNHVSFHLQPQNSVLSSLRLAS"
     gene            13177..13437
                     /locus_tag="VVO18_001511"
     CDS             13177..13437
                     /locus_tag="VVO18_001511"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586639.1"
                     /translation="MRERSATGAQGLSKSIKKHLNDLTRLTASLLGDEKLSAITSSSA
                     VKADMHRFVIELELVKSTILQNDDISLDQNEIFEILKNFFDG"
     gene            complement(14175..14574)
                     /locus_tag="VVO18_001512"
                     /pseudo
     CDS             complement(14175..14574)
                     /locus_tag="VVO18_001512"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(14733..>16141)
                     /locus_tag="VVO18_001513"
     CDS             complement(14733..>16141)
                     /locus_tag="VVO18_001513"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000256298.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU5586640.1"
                     /translation="YPTLKNFAKYDCIFVDDEDLMHTLLDLFDWFTIIDRPKICLIGS
                     RVWFEKRNLFYIHLDYRILALNTAENLESGNSSIVPVKDGKQILTNQLFDGECDDIYL
                     LTVHSPMNKALEILSEKYKQISGKNIKIIEKRYDELLEMIESGDVSSSFDMIRMDMAW
                     LPTFGKKYFQEITSFRQTKSINQNISKSVSREYMYIDQKQYTFPLDVSSQILVYRKDL
                     FEDSFLQRRYFEKTKRKLTVPKSYQEFDELSEFFTLTENPFSPTLYGHSLALSSSVRA
                     ACEFIPRFRERLAQSRMNLAVLPQVLTEYEKSYQFTEKSFNSSWNDFVTNLNSGKTSM
                     EIIFSNYTSPLFDGLNVSAQFEFATATIPGNTPVIGGGSIGISKYSNRVEECLNFINW
                     LYSEEISILLTSLGGFLPSKYVMQNRMLQFQYPWLSSLEDTFSIGSRTKWYGFNTDFR
                     FEQMLGQELIESVKHRYG"
BASE COUNT         5171 a         2607 c         3290 g         5073 t
ORIGIN      
        1 ttatttattc ttttaacttg ctattttgaa ctaaaaattt tataatgaaa ttaagcaaat
       61 aggaaggttt attatcttta atgaatacac tcgcagagaa attcagatta aaaagaaaag
      121 agctaggact ctcccaacaa actcttgcag aaggaatttg tgaacaaagc cagattagta
      181 aaattgagag agggcatttc attccctccg cagacctttt gttcaaactc tcacaacgac
      241 ttgaagtacc attagattat ttttttaatg aacaaattga aattaaatct aacctctcta
      301 atttcaagca attatctgct cgactattag atgacagaaa ttatgacaat ttggaatata
      361 tttatagaat agagattgaa cgaagtactt ttctaacact agaagaccga acttaccttg
      421 aatggattaa agctattatt gacttctatc aatatgacag taagtgtgag gctatttctt
      481 cattggaaaa tatattatta aaagtctcct caaatactct gatttattta aaggcattga
      541 atactctatc taatttctat tccttagtgg gtcgtgaaca agaatatgag gcaaactact
      601 ctcatttaat ggagttatat cagacaaaaa attttgagca tcaagagttt ttatttggct
      661 acatcagagt tcgttacaac tactctcact acctagtgtc aaaggaaaaa tataacgaag
      721 ctatccaaga agctcttgag acgattgaac tctgtaaaca aagacagaca agctaccaac
      781 tggctcccct acttattctt gtaggaaatg ctggagccaa atttctagac aaagaacaag
      841 tcaaaaatta ttatatagaa gcaagagagt tatgtaagat ttataacaat cctttaatgt
      901 tgatgaagat agaaaattat ttgaaggaat tagatactgt atagttaatc ttgacattat
      961 agtttttctg aaacgttaaa taacctgtaa ggctgatagt gaaatgaata ctatcagcct
     1021 tatttcaagt ttatattctt ccaaaatctc ttcaaaccac gtcagctcta tctgcaacct
     1081 caaaacagtg ttttgaacaa cctgcggcta gcttcctagt ttgctctttg attttcattg
     1141 agtattagcc tctcgtgttt gtttagcgtc ttaaaaagac atttgggaag attggaaaca
     1201 gttctctctt ttctccgagt ataatgattg gtaggaaggg agagagaaga tgaaatcaat
     1261 gagaatctta tttttgttag ctttaattca aatcagtttg agtagctgtt tcctatggaa
     1321 ggaatgcatc ttgtccttta aacaaagtac agcttttttc atcggaagca tggttttcgt
     1381 ttcaggaatc tgtgctggag taaattatct ttatacccgt aagcaagaag tccatagtgt
     1441 cctagccagt aagaagtcgg tgaagctttt ttacagtatg ttactcttaa ttaatttgtt
     1501 aggagctgtt cttgttttgt cagataactt gttcatcaaa aatacgctgc agcaagaatt
     1561 agttgacttt ttattgccat ccttcttttt cctatttggg ctagatttgc tgattttttt
     1621 acccttgaaa aaatacgtgc gcgattttct tgctatgcta gacagaaaaa agacagtgtt
     1681 ggtgactatt ttagcaacac ttcttttctt aagaaatcca atgaccattg tctcacttct
     1741 gatttatact ggactgggct tgttttttgc agcctatctt gtcccaaatt cggttaagaa
     1801 ggaagtttcc ttttatggtc atattttccg agatcttgta ttggtcattg ttacgctcat
     1861 tttcttttag agaaagcctg ttttttatgg atgttatgat gataagttta gtaggaaaat
     1921 agacacaaaa gaaaagtttt tggtataata agagtatgta cacaaaaaat gaagaagagt
     1981 tgcaagcctt aggggagcgt ttgggccatc tattagcaaa gaatgatgtt ttaatcttaa
     2041 ttggagaact gggtgcaggt aaaacgacct ttactaaagg acttgcaaaa ggattacaga
     2101 tttctcaaat gattaaaagt cctacctata ctatcgtgag agagtatgaa ggtcgacttc
     2161 cactttatca cctagatgtt tatcgtattg aaggagatgc tgattctatc gacttggatg
     2221 agtttatctt tggtggcggc gtgactgtta ttgagtgggg aaatctctta ggagatgcct
     2281 tgccagatgc ttatttagaa ttggaaattc taaaagaagc agatggacgc cgtttaaatt
     2341 ttcaggcaaa gggtttgcgt gctgagaaat tgttagagga gcttcaatat ggagtatgaa
     2401 ttgctcatta gggaagcaga gcccaaagat gcagctgaat tagtggcctt tttaaatcgt
     2461 gtgagtttgg agacagactt taccagccta gacggagatg gtattctctt gactagtgag
     2521 gagatggaaa tattcctcaa caagcaagct agttcggaca atcagataac cttacttgca
     2581 ttcttaaatg gcaaaattgc tggtattgta aatattacag ctgaccagcg taagagagtc
     2641 cgtcatattg gagatctctt cattgtgatt ggaaaaagat attggaataa tggcttggga
     2701 agtttgttgc tagaagaagc gatagagtgg gcacaagcaa gtggcattct gcgtcgtctc
     2761 caactgactg tccaaactcg taatcaagca gcagtccatc tttatcaaaa gcatggcttt
     2821 gtcattgaag gtagccaaga gcgtggggca tatatagaag aagggaaatt tatcgatgtt
     2881 tacttgatgg gtaaactgat agattagtag aaatatggtt aaaaaaatta ttggaatggt
     2941 gctagcttta ctttctgtaa ctgtagtagg agtaggtgtt tttgcttata ctatttatca
     3001 acaagggaca gaaaccttag ctaaaaccta taaaaaaatc ggcgaagaaa ccaaggttat
     3061 tgaagcgact gaacctctaa ccattctgtt aatgggagtg gacaccggaa atgctgaacg
     3121 aactgaaact tgggtcggta gaagtgatag catgatcttg atgacagtga atcctaaaac
     3181 gaaaaaaaca acaatgatga gtttagagcg ggatattctg acgcgcattg aatcagggaa
     3241 tggtcaggct catgaagcga aactgaactc agcatatgca gatggtggag cagagcttgc
     3301 tatagaaacc attcaaaaaa tgatgaatat ccatattgat cgctatgtga tggtcaatat
     3361 gagagggttg caaaaactag tggatgcagt aggaggtatt acagtcaata atatcctagg
     3421 tttcccaatt tctatcagtg accaagaaga atttaatact atttctatcg gtgttgggga
     3481 gcaacatatt gggggagaag aagccctagt ctatgcacga atgcgttacc aagatcctga
     3541 gggggattat ggtcgtcaaa aacgtcaacg tgaagttatt caaaaagtca tggaaaaagc
     3601 tctcagttta aatagcgttg gtcattatca agagattcta aaagctttga gtgacaatat
     3661 gcagaccaat attgatttgt ctgcaaaaag tatccctaac ttgctaggct ataaagattc
     3721 atttaaaacc attgaaactc agcagttgca gggtgaagga gagatacttc aaggtgtttc
     3781 ttaccagatt gtttcgagag cacatatgtt ggaaatgcaa aatatactcc gacgttcttt
     3841 gggacaagaa gaagttactc agcttgaaac caatgcggtt ttatttgaag atttatttgg
     3901 cagagcacct gttggtgatg aagataatta acttttgata caaataaaaa aatcaatcgt
     3961 aggaaaattc ctgcgatttt ttcaaaaaaa tacgaataga taggtaggag gaaacatgaa
     4021 agcagaaatc attgctgttg gaacagagat tttgacagga cagattgtca acaccaatgc
     4081 ccagtttttg tcggaaaaac tagctgagat tggggtagat gtatattttc agacggctgt
     4141 aggagacaat gaagttcgtc tcttgtcttt gcttgagatt gccagtcaac gtagcagtct
     4201 ggtgattttg acaggcggtt tggggccaac tgaggacgac ctaaccaaac aaaccctagc
     4261 taaattttta gggaaagcat tagtctttga tcctcaggct caggagaagt tggatatctt
     4321 ttttgccctg cgaccagact atgcccgaac accgaataac gaaagacaag ctcaaattgt
     4381 agaaggagcg attccactgc caaacgaaac aggactggct gttggaggaa aattagaagt
     4441 agacggagtg acctatgtcg tccttccagg tccgccaagt gaattgaaac ccatggtctt
     4501 aaaccaactt ctacccaagt tgatgacagg gaacaagctg tattcccgag ttcttcgttt
     4561 ctttgggatt ggcgagagcc agttggttac gattttggct gatttaattg ataatcagat
     4621 cgatcctacc ttggcccctt atgccaagac aggagaagtc actctacgtc tgtcaacaaa
     4681 ggctagcagt caagaagagg cgaatcaagc gctggatatc ttggaaaatc aaatcttgga
     4741 ctgccagact ttcgaaggaa tttctttacg agacttttgc tatggttatg gggaagaaac
     4801 tagtttagcc agcattgtgg tagaagaact gaaaaggcaa gggaaaacca tcgcggctgc
     4861 agagagtttg acggcaggtc ttttccaagc taccgtggcg aatttttctg gagtttcaag
     4921 tatatttgag ggtggttttg tgacctatag cttggaggaa aaatcaagga tgttggatat
     4981 tcctgccaag aatttggaag aacatggtgt ggtgtctgaa tttacagctc agaagatggc
     5041 tgagcaggca cgaagcaaga cccagtctga ttttggaatt agtttgactg gagtggcagg
     5101 accagatagc ctagaaggac acccagttgg gacagtcttc ataggcttgg cgcaagatca
     5161 aggaactgag gttatcaagg ttaatattgg aggcagaagc cgagcagatg tacgtcacat
     5221 tgcggttatg catgccttta acctagttcg caaggcttta ttaagtgact aacttttgat
     5281 ataatagtag ataggtctga ggatcattag aatgtaggag aatagaatgg cgaaaaaacc
     5341 aaaaaaatta gaagaaattt caaaaaaatt tggggcagaa cgtgaaaagg ccttgaatga
     5401 cgctcttaaa ttgattgaga aagactttgg taaaggatca atcatgcgtt tgggtgaacg
     5461 tgcggagcaa aaggtgcaag tgatgagctc aggttcttta gctcttgaca ttgcccttgg
     5521 ctcaggtggt tatcctaagg gacgtatcat cgaaatctat ggcccagagt catctggtaa
     5581 gacaacggtt gcccttcatg cagttgcaca agcgcaaaaa gaaggtggga ttgctgcctt
     5641 tatcgatgcg gaacatgccc ttgatccagc ttatgctgcg gcccttggtg tcaatattga
     5701 cgaattgctc ttgtctcaac cagactcagg agagcaaggt cttgagattg cgggaaaatt
     5761 gattgactca ggtgcagttg atcttgtcgt agtcgactca gttgctgccc ttgttcctcg
     5821 tgcggaaatt gatggagata tcggagatag ccatgttggt ttgcaggctc gtatgatgag
     5881 ccaggccatg cgtaaacttg gcgcctctat caataaaacc aaaacaattg ccatttttat
     5941 caaccaattg cgtgaaaaag ttggagtgat gtttggaaat ccagaaacaa caccgggcgg
     6001 acgtgctttg aaattctatg cttcagtccg cttggatgtt cgtggtaata cacaaattaa
     6061 gggaactggt gatcaaaaag aaaccaatgt cggtaaagaa actaagatta aggttgtaaa
     6121 aaataaggta gctccaccgt ttaaggaagc cgtagttgaa attatgtacg gagaaggaat
     6181 ttctaagact ggtgagcttt tgaagattgc aagcgatttg gatattatca aaaaagcagg
     6241 ggcttggtat tcttacaaag atgaaaaaat tgggcaaggt tctgagaatg ctaagaaata
     6301 cttggcagag cacccagaaa tctttgatga aattgataag caagtccgtt ctaaatttgg
     6361 cttgattgat ggagaagaag tttcagaaca agatactgaa aacaaaaaag atgagccaaa
     6421 gaaagaagaa gcagtgaatg aagaagttcc gcttgactta ggcgatgaac ttgaaatcga
     6481 aattgaagaa taagctgtta aagcagtgga gaaatccgct actttttcga tttttgattc
     6541 aagtttttag attatatata gtagcttgaa ataagatatg aacaacttta ttaggaaagt
     6601 caaattaatt tctagaaatg ttttagcagc tacagcgtac tattccaaac tcaaccaact
     6661 ataatagatc gaaactagaa tagtacacat ctacttctaa aacattgtta aaaatcgatt
     6721 tgactgtcct tatttcattc cgctatatat aagtttgctg tttcttgtcg ctcctctgga
     6781 aagctgatat aatagcttta tgaataaaaa acgaacagtg gacctgatac atggtccgat
     6841 tcttccctcg ctcttaagct tcacctttcc aatcttgcta tcaaatattt ttcaacagct
     6901 ctataacact gctgatgtct tgattgttgg acgatttctt ggtcaagaat ccttggctgc
     6961 agtaggagcg acgacagcga tttttgacct gattgtaggc tttacacttg gtgttggcaa
     7021 tggcatgggg attgtcattg ctcgttatta tggggctcgg aatttcacta aaatcaagga
     7081 agcagtagca gccacctgga ttttaggtgc tcttttgagc attctagtta tgttgctggg
     7141 ctttcttggc ttgtatcctc tcttgcaata cttagatact cctgcagaaa ttcttcctca
     7201 atcttatcaa tatatttcta tgattgtgac ctgtgtaggt gtcagctttg cttataatct
     7261 ttttgcaggc ttgttgcggt ctattggtga cagtctagca gccctgggat ttctgatttt
     7321 ctctgccttg gttaatgtgg ttctggatct ctattttatt acgcaattgc atctgggagt
     7381 tcaatccgca ggacttgcta ccattatttc gcaaggttta tcagcggttc tctgctttta
     7441 ttatattcgt aaaagtgtgc cagaactctt gccacagttt aaacatttca aatgggacaa
     7501 aagcttgtac gcggatctct tggagcaagg tttggctatg ggcttgatga gttcaattgt
     7561 atctatcggc agtgtgattt tacagttttc tgttaataca tttggtgcag tgattattag
     7621 tgcccagacg gcagctcgac gcattatgac ctttgccctt cttcctatga ccgctatttc
     7681 tgcatcaatg acgacctttg cttctcagaa tctaggagct aagcgacctg accgtattgt
     7741 tcaaggtctt cgaatcggca gtcgtttaag tatatcctgg gcagtttttg tttgtatttt
     7801 cctctttttt gccagtccag ctttggtttc cttcttggct agttcgacag atggttactt
     7861 gatagaaaat ggaagtctct atctgcaaat cagttcaacc ttttatccca ttttgagcct
     7921 cttgttgatt tatcgcaatt gcttgcaggg cttggggcaa aagatccttc ctctagtttc
     7981 tagctttatt gaactaatcg gaaaaatcgt ttttgtggtt ttgattattc cttgggcagg
     8041 atataagggt gttatccttt gtgaacctct tatctgggtt gccatgacag ttcaactgta
     8101 cttctcatta ttccgtcatc ccttgataaa agaaggcaag gcaatcttgg caaccaaagt
     8161 gcaatcctag ttggatttac tgaataaaat ccatttcctc tagtgaaaat cgaaaaaact
     8221 tgtgttctcg tctttagttt ggtgttgaaa atagtttaac agacttttga cttcttttat
     8281 atgatataat aaagtatagt atttatgaaa aggacatata gagactgtaa aaatatactt
     8341 ttgaaaagct ttttagtctg gggtgttatt gtagatagaa tgcagacctt gtcagtccta
     8401 tttacagtgt caaaatagtg cgttttgaag ttctatctac aagcctaatc gtgactaaga
     8461 ttgtcttctt tgtaaggtag aaataaagga gtttctggtt ctggattgta aaaaatgagt
     8521 tgttttaatt gataaggagt agaatatgga aattaatgtg agtaaattaa gaacagattt
     8581 gcctcaagtc ggcgtgcaac catataggca agtacacgca cactcaactg ggaatccgca
     8641 ttcaaccgta cagaatgaag cggattatca ctggcggaaa gacccagaat taggtttttt
     8701 ctcgcacatt gttgggaacg gttgcatcat gcaggtagga cctgttgata atggtgcctg
     8761 ggacgttggg ggcggttgga atgctgagac ctatgcagcg gttgaactga ttgaaagcca
     8821 ttcaactaaa gaagagttca tgacggacta ccgcctttat atcgaactct tacgcaatct
     8881 agcagatgaa gcaggtttgc cgaaaacgct tgatacaggg agtttagctg gaattaaaac
     8941 gcacgagtat tgcacgaata accaaccaaa caaccactca gaccatgtgg atccataccc
     9001 ttacttggca aaatggggca ttagccgtga gcagtttaag catgatattg agaacggctt
     9061 gacgattgaa acaggctggc agaagaatga cactggctac tggtacgtac attcagacgg
     9121 ctcttatcca aaagacaagt ttgagaaaat caatggcact tggtactact ttgacagttc
     9181 aggctatatg cttgcagacc gctggaggaa gcacacagac ggcaactggt actggttcga
     9241 caactcaggc gaaatggcta caggctggaa gaaaatcgct gataagtggt actatttcaa
     9301 cgaagaaggt gccatgaaga caggctgggt caagtacaag gacacttggt actacttaga
     9361 cgctaaagaa ggcgccatgg tatcaaatgc ctttatccag tcagcggacg gaacaggctg
     9421 gtactacctc aaaccagacg gaacactggc agacaagcca gaattcacag tagagccaga
     9481 tggcttgatt acagtaaaat aataatggaa tatctttcaa atcagaacag cgcatattat
     9541 taggtcttga aaaagcttaa tagtatgcgt tttcttgtgg agatatttcc ttcaattttt
     9601 gctactatat taaacaaaaa tcaaaaagca aactagaaag ttatgctcaa ataaaatcta
     9661 aatttgacaa tgtaaaccga gtcggatagc tttaagtact gttttgaggt tgaagatacg
     9721 atttttgata ggaactcatc aattttagat ttttaagcag catcaataaa ttgcttcctt
     9781 gttttgtcat aattttttta tttaaaaaat tatgacaaga gtgtgctatt ctttttatga
     9841 gaggtgtatg aatatgataa atgtatgtga taaatgtatg tgatgttgga aaaagaataa
     9901 aagaacttag aatatcttca aatcttactc aagataagat tgctgagtat ttgtctttga
     9961 atcaaagcat gattgccaaa atggaaaaag gtgaaaggaa tatcacgaat ggatttaagt
    10021 aataaagctc caaatcttag aaaaaagttg ggagctgatg gtgaatcgcc gatagatatt
    10081 tttaaattgg tacaaaagat agaaaatttg acgctggtat tttatggact cggaaagaat
    10141 attagcggag tctgttataa aggaactcag ttcagtctca ttgcagtcaa ttcagacatg
    10201 tcattaggaa ggtaaagatt ttctttagca catgaactgt atcatcttta ttatgatgag
    10261 gtgaagaaga gttcagtcag tcttatcttg attggtgaag gagatgaaac tgaaagaaaa
    10321 gcggatcagt ttgcttctta ttttttaatt ttcccatctt cactgtatag gatggttgag
    10381 gaaattagag aaaatgccaa tagaactcat cttgaagtag aagatattat aaaattgggt
    10441 cagttttatg gtatcagtca taaagctatg ttatatagat tgagaaatga tggatacctt
    10501 gatgcagaag aaattaaaaa tatggatatt agtgttatag agacagcttc aagattaggc
    10561 tatgatacaa gtttatatcg tcctttgtca gaaagtaaaa aggaaacggt attaggataa
    10621 tatattaatt cgactgaaca acttttagaa aataacagaa tttcgcaagg gaagtatgag
    10681 gaactgttac tagatgcttt cagatatgat attgtatatg ggctatatga agaggaggga
    10741 gttgtcgttt gactagtcgt gtatttattg atgcagattg tatttcagta tttttatggg
    10801 ttggcactga acatctttta gaaaagctct attcgggtaa aattgttatt ccacaagagg
    10861 tgtatgatga aatcaatata cctacaattc cccatttaaa atctaggata gaccagttgg
    10921 tagctaaggg ttcagctgag attgtgagca tagacattgg aactgaagaa tacgcattat
    10981 atagagattt aacaagaaat catgatagta acaagattat tggtaaggga gaagcggctt
    11041 ctatttcctt agcgaaaaag cataatggga tattaggaag taataaccta agagatgtta
    11101 aatcatatgt agaagaattt tctttagaac atatgacaac aggagatata ctgattgaag
    11161 cgtttaaagt gtaatttatt actgaacaag agggcaatca tatctggaat aatatgctta
    11221 aaaagagaag gaaaattggt gcaaattcat tttcagacta tcttcgtgga agtattcatc
    11281 aaaatagaca aaaataaatt tggataaatc gaactcacta ttcaggaggc atatgagcaa
    11341 ttcgaaaaag aaaagtgtca aattgagcct ataggagtag aagtgaaata gtaagtcctg
    11401 catagtggat gagagaaaag ttctccttga agttttcctg aactatcagt cgcatgtcaa
    11461 acgatatgta gggtaatgtg agaggggata gcgagtagtt tttggttatt ttatcaaaaa
    11521 acttatattt tattatactg aatgataaaa tataataaaa atgatagaat aaggaaaaaa
    11581 catgaatgtc aaaaagataa tgtcaatttt tcaatccttt tatgttgatg tcagtattga
    11641 ggaactgact ttgactttac caatcagttt tgtaaaaagg tttgagtata ctcaaatgac
    11701 ttttcataag gaatcatttt tattgattaa agaaaagaga agggggagtt tgagttcatt
    11761 tgttactcag gctcgcacta tgggtgaaaa agccaatatg gatgttgttt tggtgttttc
    11821 gaagttatca gacagtgaaa aaaagcaatt acttcaagct agagttccgt ttgtagactt
    11881 taagggaaac ctcttcttcc ctccattggg actagtactg aatgcgaatg atactgaagt
    11941 ccctaaggaa ttaacaccta gcgaacaatt aacgtggatt gcctttttat tgacaaaagg
    12001 tcaaaaagta gtagatgttg atttgctttc acaagtcact ggacttccaa actcaacaat
    12061 ttataggtgt ttgaggactt ttaaagcttt atattggtta aacaagcaaa ataagcttta
    12121 cacatatacg gtgtcaaaga aagaattatt cttaaaatcc gtgtcatgtt tatttaatcc
    12181 catcaaaaaa cggattttat tgccagatgg cgatataaag cagataaaat ctgtttctaa
    12241 ccttctatat ggtggtgctt atgctttgtc gcattcaact tttttagctg aaacggatga
    12301 aaatactagc tatgtcatat ggcagagaaa attcaatcag ttatccttgc cactttctca
    12361 gtatgtttta aaatgaaaga tgctagagat atggaaatat cgtccttttg tatctgagtt
    12421 ttggaatgat tttaaaaata atcatgataa acaatttgta gatccgattt ctctttattt
    12481 gaccttaaaa gatgatgatg acccacgtat agaggaagag agtgaagcac tagaaaatat
    12541 gatattacag tatctgggag aagatgatgc cagctaatac gaaagttatt tttcaagaaa
    12601 tgtttgcgga ttttcagaac tattatgttc tgattggggg aactgctacc tctatcgtat
    12661 tggattcgca aggatttaaa agtcgcacaa caaaagatta tgatatggtc atcattgatg
    12721 aagtaaaaaa taaggaattt tatactacct tgaatcattt tttagaattg ggagagtatc
    12781 aaggaagtca gaaagatgag aaagcgcagc tttttcgatt tacaacaact aatcttgagt
    12841 ttccttctat gattgaacta tttagtatct taccagaata tccattaaag aaggacggtc
    12901 gagaaatttc cttatatttt gaccaagatg ctagtttatc agccttatta ttggatgaag
    12961 attattataa tatattggtg catgtaaaag aaaccattca ggggtattcg gtattgagta
    13021 attgtggtct atactcttcg acaatctctt caaaccacgt cagcttccat ctacaacctc
    13081 aaaacagtgt tttgagcagc ctgcggctag cttcctagtt tgctctttga ttttcattga
    13141 gtattaatta tttttaaggc taaagcttgg ctggatatga gggaacgctc tgctacaggt
    13201 gctcaaggtt taagtaagtc cattaaaaag catttgaatg accttacccg tttgacagct
    13261 tccttgctag gagatgaaaa gttatcggct ataacatcaa gtagtgcggt aaaagcagac
    13321 atgcaccgct ttgtgataga attagagctt gtgaagtcaa ctattcttca aaatgatgac
    13381 atttcattag atcaaaatga aatttttgaa attctgaaaa attttttcga tggttaaaat
    13441 aattgtagcg agatggctat attgaattcg tctatatctg gaaactagaa aaaacttcaa
    13501 tttcaggaga aaatgaagtc aatcttccca caatcaaacg tatagtatca aggtttttca
    13561 agacctgata ttatgcgttt tttgcttttc aaaacttttt gcccagtttt tgtttttatc
    13621 ctctagtcac ttgatttgtt tcaggtggtt ttttagtata gtaaaatgaa acgagaacag
    13681 gacaaattga tcaggacagt caaatcgatt tctaacaatg ttttagaagc agaagtgtac
    13741 tattctagtt tcaatctact atagttaaat ctgcggtcaa gtctactggt gaatctatga
    13801 ttgtaatact cttccaaaat ctcatcaacc acgtcagtct tgccttgcag tctgtatctt
    13861 actgaccaag ctagtgatgg atttagaata ggtgatttgg agcgtcctat tggctaggaa
    13921 atgctgctca tagtcctttg ctgaggctag ggtgtttcaa cattcaacac tcaactggtt
    13981 gatctagttg ataggaaggg agttactata aaatactcag gcttccatca tattttttga
    14041 aacgattgtg taatcaaaat gtaccaatat tgtagtattg gtacagaaga tgttgtgaat
    14101 ggataaatat atcataactg ctatctcaaa aagatttcat atgtctgtgc atatataata
    14161 gacttcctgc aaaactagaa tcctagttca tgattgataa taccagcaat caaattcatt
    14221 cgtaatccaa agcgtttacg atgatttcga taggttgttg aaaacatttt aaacgtttct
    14281 actttggcaa agatgttctc aaccttgctt ctctccttag atagcgcatg gttataggtt
    14341 ttatcttcaa ctgttagcgg cttgagtttg ctggatttac gtggagtttg tgcttgagga
    14401 tatatcttca tgagcccttg ataaccactg tcagccaaga ttttaccagc ttgtccgact
    14461 tttttgataa gctgttttta atacagctaa tatctcttca aaagtggtac gctgaacacc
    14521 aacaagacgc ttaaatcgtg tatcagttaa ttgtttactt gcttcataat tcatagaact
    14581 actataccat attttgtttc gcagggagtc taataaaata actttgcaat agaaaaatgc
    14641 caaaataata attttaaata taattggtgt ttacttgaat ctttaatttt aaacaataat
    14701 aaataaacta gtaataaaaa tttagtatta atttatccat atctatgctt cacactttct
    14761 attaactctt gccctaacat ctgctcaaat ctaaaatcag tattaaagcc gtaccatttt
    14821 gttctactcc caatactaaa tgtatcttct aaactagata accatggata ttgaaattgt
    14881 aacatcctat tttgcatgac atactttgat ggtaaaaaac cacccagaga tgttagtaaa
    14941 atagaaatct cttcagaata taaccaatta ataaagttta gacattcttc cactctattt
    15001 gaatatttag aaattccaat tgagccacca cctatcacag gagtattacc aggtatagtg
    15061 gcagttgcaa actcaaactg agcagaaaca ttgagaccat caaataatgg actagtataa
    15121 tttgaaaaaa ttatttccat tgaagtttta ccactgttta agttcgtaac gaaatcgttc
    15181 cacgaagaat taaatgattt ttcggtaaac tgataacttt tctcatactc ggttaaaacc
    15241 tgaggaagta cagcaagatt cattctagat tgtgctaatc tctcacgaaa ccgaggaata
    15301 aattcacatg ctgctctcac tgaagaactt aaagctaaac tatggccata aagtgtaggt
    15361 gaaaatggat tttctgttaa tgtaaaaaat tcacttaact catcaaactc ttgataactt
    15421 tttggtacag ttaattttct ttttgttttt tcaaagtatc gtctttgtaa aaatgaatct
    15481 tcaaataagt cttttctata tactaaaatc tgactactaa catccaatgg aaaagtatat
    15541 tgcttctgat caatatacat atactctcga gacaccgact tagaaatatt ttgattaata
    15601 ctttttgttt gtctaaagct tgtaatctct tgaaaatact ttttcccaaa tgttggaagc
    15661 caagccatat ccattctaat catatcaaaa ctggatgaaa catcgccaga ctcaatcatc
    15721 tccaaaagtt catcatatct tttctcgata attttaatat ttttcccaga aatttgttta
    15781 tacttttctg ataaaatttc taaggcttta ttcattggtg aatggacagt aagtaaataa
    15841 atatcatcac attctccatc aaataattga ttagttaaaa tttgtttgcc atctttaact
    15901 ggtacaattg aactatttcc actttctaaa ttttcggcag tattgagtgc caatattcta
    15961 taatctaaat gtatataaaa aagatttctt ttttcgaacc aaacacgtga acctatcaaa
    16021 catatttttg gtctatcaat tatagtaaac caatcaaata agtctaatag cgtgtgcatc
    16081 aaatcttcat catcaacaaa tatacaatca tactttgcaa agttttttag agtaggatat
    16141 a
//
LOCUS       DAVHIZ010000042        16027 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.044, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000042 DAVHIZ010000000
VERSION     DAVHIZ010000042.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 16027)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16027)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16027
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.044"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            519..1382
                     /locus_tag="VVO18_001514"
     CDS             519..1382
                     /locus_tag="VVO18_001514"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000572848.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEU5586641.1"
                     /translation="MIERMELGEFYKELRLARKLKQTDVACEGLTASQLSKFELGQSM
                     LSADKLILAIQGINVTFDEFGHKLNNYQESPHMRIGRKVVNRFAHQDIAALEQLLEEV
                     DQEQMAQTYRRLNAIVIKDAIHSLNKSYPLAEEDSEFLTTYLYAIESWTWFELYLFCN
                     TMPFLSNQDLIFLSTSLLEKSKEFKELVHNRLYMKQGLLNILSELMERKLFSYIPIFE
                     AELERMLRPYDVFEKVSWQFLKKMSVFLQTKGSNQKEIERFIQSLQVLENPQLTSLFE
                     LRFQQYKELID"
     gene            1673..1870
                     /locus_tag="VVO18_001515"
     CDS             1673..1870
                     /locus_tag="VVO18_001515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000933470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide pheromone VP1"
                     /protein_id="HEU5586642.1"
                     /translation="MLNLQFAETMELTEAELETVYGGEFGNNAVIPAGAWGGLGTSWS
                     ITNFWKKYFNHDSSTVNRRHY"
     gene            1938..2603
                     /locus_tag="VVO18_001516"
     CDS             1938..2603
                     /locus_tag="VVO18_001516"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000720786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CPBP family intramembrane metalloprotease"
                     /protein_id="HEU5586643.1"
                     /translation="MKKIISHRYFIIVFLLVIADQKFSVLVLRSDLVTGLSDFAYYLS
                     DMMLNFLVVLFALIAMIWSGKWQKINSRKFKGSYLFYSFLALLAFVVWNFVTFFLFPP
                     TRNEISYQHAAPTFTGATAFLMYFFYPVIAGPIFEEIIHRGLVMTALEKGKKWGLDVL
                     GSAILFGVSHISNHGWVLTDFVFYMGGGLIFVVLFRMTKSIYWPIGLHIVYNGIGQLL
                     MLL"
     gene            2675..3901
                     /locus_tag="VVO18_001517"
     CDS             2675..3901
                     /locus_tag="VVO18_001517"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862399.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU5586644.1"
                     /translation="MKVFLQNRDFRQLTINQWISTLGDTIFYLAFLNYVADASFAPLA
                     ILLITISETLPQVLQIFLGVLADFQHHRVLKYTVISFTKFLLYSIVSLSLSGQSFSLL
                     LVTFICLINLLSDTLSYFSGAMLTPIFIRIIGQDHLAEAIGFKQSTVSLVKTISNILG
                     GVLLGILSIQFISLLNALTFLIAFLGILFIKTDLLKVEKTINYQEGLSVKSFCQHLLQ
                     SSKLIWNMNKVLLVLFIISTSQAVINVTVPVSTLFLRNQPFLNLQTGQSLALLSTFEL
                     SALIVGSLVSGYLQHTISIKTALYASLVIQLLLLVGFATVRFDWILIFSTLDAFFAGV
                     LSPRLQELVFKQIPEESMGAVQSSIGAITVVLPSLFTIALVTIATSFGTLAVSFVLLL
                     FLLVAFVMLLNIRESI"
     gene            4355..5011
                     /locus_tag="VVO18_001518"
     CDS             4355..5011
                     /locus_tag="VVO18_001518"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlC family ABC transporter permease"
                     /protein_id="HEU5586645.1"
                     /translation="MPTALGYVSIGLACGTIGAPYVTPVEMGLMSLFVYAGSAQFAML
                     ALIVVQAPVAAIAMTVFLINLRLFLLSLHASTYFRHTSLWYNIGMSSILTDETYGVLM
                     GELAHTDKVNPMWMHGNNLNSYVAWFVGTVVGTALGGLLPNPEIFGLDFALVGMFIGI
                     FASQFQIMQRRIPVRNLLIILAVVAVSFFLLLTVVSQSLAVLFATLLGCSMGVVLDGQ
                     "
     gene            5001..5324
                     /locus_tag="VVO18_001519"
     CDS             5001..5324
                     /locus_tag="VVO18_001519"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000253911.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AzlD domain-containing protein"
                     /protein_id="HEU5586646.1"
                     /translation="MVSKYLLLAVIFSGLVTWILRMIPFILVKYKGLPAIVERFLKFL
                     PVSIIFALILSSVVTGKVGSLPQIKWLDFLAVFPTAWVAFRYRNLVGTVLFGVVLIAI
                     LRLVF"
     gene            5428..6258
                     /locus_tag="VVO18_001520"
     CDS             5428..6258
                     /locus_tag="VVO18_001520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397236.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586647.1"
                     /translation="MKKIVKYSSLAALGLVAAGVLAACSGGAKKEGEAASKKEIIVAT
                     NGSPRPFIYEENGELTGYEIEVVRAIFKDSDKYDVKFEKTEWSGVFAGLDADRYNMAV
                     NNLSYTKERAEKYLYAAPIAQNPNVLVVKKDDSSIKSLDDIGGKSTEVVQATTSAKQL
                     EAYNAEHTDNPTILNYTKADFQQIMVRLSDGQFDYKIFDKIGVETVIKNQGLDNLKVI
                     ELPSDQQPYVYPLLAQGQDELKSFVDKRIKELYKDGTLEKLSKQFFGDTYLPAEADIK
                     "
     gene            6412..7266
                     /locus_tag="VVO18_001521"
     CDS             6412..7266
                     /locus_tag="VVO18_001521"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000694494.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MetQ/NlpA family ABC transporter
                     substrate-binding protein"
                     /protein_id="HEU5586648.1"
                     /translation="MKIKKWLGLAALATVAGLALAACGNSEKKADNATTIKIATVNRS
                     GSEEKRWDKIQELVKKDGITLEFTEFTDYSQPNKATADGEVDLNAFQHYNFLNNWNKE
                     NGKDLVAIADTYISPIRLYSGLNGSANKYTKVEDIPANGEIAVPNDATNESRALYLLQ
                     SAGLIKLDVSGTALATVANIKENPKNLKITELDASQTARSLSSVDAAVVNNTFVTEAK
                     LDYKKALFKEQADENSKQWYNIIVAKKDWETSPKADAIKKVIAAYHTDDVKKVIEESS
                     DGLDQPVW"
     gene            7366..8739
                     /locus_tag="VVO18_001522"
     CDS             7366..8739
                     /locus_tag="VVO18_001522"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="HEU5586649.1"
                     /translation="MVFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKE
                     VANYLGEIFKRVGAEVEIDESYTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQVW
                     TEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISFIMEGAEESA
                     STDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNKGIVTFDAKVKSADVDIH
                     SSYGGVVESAPWYLLQALQSLRAADGRILVEGLYEEVQEPNEREMALLETYGQRNPEE
                     VSRIYGLELPLLQEERMAFLKRFFFDPALNIEGIQSGYQGQGVKTILPAEASAKLEVR
                     LVPGLEPHDVLEKIRKQLDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYP
                     QGVSVLPTTAGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVE
                     ELIRSYE"
     gene            8732..9793
                     /locus_tag="VVO18_001523"
     CDS             8732..9793
                     /locus_tag="VVO18_001523"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000085652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="methionine ABC transporter ATP-binding protein"
                     /protein_id="HEU5586650.1"
                     /translation="MSRDIIKLDQIDVTFHQKKRTITAVKDVTIHIQEGDIYGIVGYS
                     GAGKSTLVRVINLLQKPSAGKITIDDDVIFDGKVTLTAEQLRRKRQDIGMIFQHFNLM
                     SQKTAEENVAFALKHSELSKEEKKAKVAKLLDLVGLADRAENYPSQLSGGQKQRVAIA
                     RALANDPKILISDESTSALDPKTTKQILALLQDLNQKLGLTVVLITHEMQIVKDIANR
                     VAVMQDGHLIEEGSVLEIFSDPKQPLTQDFISTATGIDEAMAKIEKQEIVEHLSENSL
                     LVQLKYAGASTDEPLLNELYKHYQVMANILYGNIEILDGTPVGELVLVLSGEKAALAG
                     AQEAIRQAGVQLKVLKGVQ"
     gene            9795..10487
                     /locus_tag="VVO18_001524"
     CDS             9795..10487
                     /locus_tag="VVO18_001524"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586651.1"
                     /translation="MESLIQTYLPNVYKMGWAGQAGWGTAIYLTLYMTVLSFIIGGFL
                     GLVAGLFLVLTAPGGVLENKVVFWILDKITSIFRAVPFIILLAILSPLSHLIVKTSIG
                     PNAALVPLSFAVFAFFARQVQVVLAELDGGVIEAAQASGATFWDIVGVYLSEGLPDLI
                     RVTTVTLISLVGETAMAGAVGAGGIGNVAIAYGFNRYNHDVTILATIIIILIIFAIQF
                     LGDFLTKKLSHK"
     gene            complement(10517..11086)
                     /locus_tag="VVO18_001525"
     CDS             complement(10517..11086)
                     /locus_tag="VVO18_001525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000748387.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEU5586652.1"
                     /translation="MKKSILTTLLFAVLYFLCMGIGVLLGNLFDQTGNMFYAPAFTAL
                     VGGSVYMILVAKVPRFGAITTIGLVIAFFFLGTKHGAGSFLPGIICGLLADEVAHLGK
                     YKDKTKNFLSFIIFAFSTTGPILLMWIAPKAYMATLLARGKSQEYIDRIMVAPTPGTV
                     LLFIASIVIGALVGALIGQALSKKFAQKI"
     gene            11221..11835
                     /locus_tag="VVO18_001526"
     CDS             11221..11835
                     /locus_tag="VVO18_001526"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000532354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YesL family protein"
                     /protein_id="HEU5586653.1"
                     /translation="MGRFLDFVFNRFFLGMIATAFFWLLTLAGGIILGLAPASATLMS
                     LYAEHGYSFREYSLKEAWSLYKQNFVSSNLIFYSFLGVGLVLTYGLYLLVQLPHQTIV
                     HLIATLLNVLVVALIFLAYTVSLKLQVYFALSYRNSLKLSLIGIFMSLAAVAKVLLGT
                     VLLVAIGYYMPALLFFVGIGMWHFFISDMLEPVYEIIHEKLATK"
     gene            11837..13483
                     /locus_tag="VVO18_001527"
     CDS             11837..13483
                     /locus_tag="VVO18_001527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5586654.1"
                     /translation="MKQFWLHTLLRTYSSVMIIIIASFAILLSYADWDSREKEAQRVA
                     QRVTARTVSEIEYYHRESTQIAQALVENQARIEGIYKYFSLSMPDYFYWQLERKASPY
                     ISVSLYENVDDLYVRNDFVTGVAIAFQDYKEVYVSTKDKRSGEKIRAEDFKPAGNSFA
                     IPVSDPVSDQDLGVIYISLNPAVLYHAIDNTRGHTPMAVTVTSPFDTEIFHIGETVDR
                     ESENWLVGLTSHGYQVQVAVPKNFVLQGTVTSSALIVGLSLLFIVILYLTLRQTFANY
                     QKQVVDLVESIQVIAQGEEGRRIDISEKDQELLLIAETTNDMLDRLEKNIHDIYQLEL
                     SQKDANMRALQAQINPHFMYNTLEFLRMYAVMQSQDELADIIYEFSSLLRNNISDERE
                     TLLKQELEFCRKYSYLCMVRYPKSIAYGFKIDPELENMKIPKFTLQPLVENYFAHGVD
                     HRRTDNVISIKALKQDGFVEILVVDNGRGMSAEKLANIREKLSQRNFEHQASYSDQRQ
                     SIGIINVHERFVLYFGDRYAITIESAEQAGVQYRITIQDE"
     gene            13495..14781
                     /locus_tag="VVO18_001528"
     CDS             13495..14781
                     /locus_tag="VVO18_001528"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586655.1"
                     /translation="MYKVLLVDDEYMVTEGLKRLIPFDKWDMEVVATVSHADEALEYV
                     QENPVDVIISDVNMPDKTGLDMIREMKEILPDAAYILLSGYQEFDYVKRAMNLSVVDY
                     LVKPVDKVELGNLLEKIAGQLGERGKKSQTLSQELDEAEFVSYLGDKENWWIGLSKEK
                     QGSFTIPYYVLGQAWQIFISDQPLDGLVVTPFEAPYQEHFERWKLNAEKTLFYGSVNL
                     QQSESLFAYYEPIYRVIIQGNLNQIVEELNLLEKVVLENTPRIPITKQLFIQFVMDVF
                     HLFEHLKADDMTDIVKTIHAIQSFDELVSYIKETLISFFGQYRMNENVVSVLEVIGRD
                     YQKELSLKDISKALFINPVYLGQLIKRETDSTFAELLNKQRIKAAQQLLLSTSDSIED
                     ICYAVGYSNLGYFYKVFRKLCGKSPKAYRKQVETIL"
     gene            14833..15366
                     /locus_tag="VVO18_001529"
     CDS             14833..15366
                     /locus_tag="VVO18_001529"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399110.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586656.1"
                     /translation="MKKKPIYLWVLLILSALISVPSLFGIVSPLPSKEALRAAQKQVA
                     GVNAQQLEDQLNYTYRVAEASHSIFNVALIVLSTILVVVAIVFLVRKNLQYANYTYVG
                     YVLLAIIGSIYGYVGLQDAVQLVQDESMRLTVSIGSKAVSIFYIVINVLFLALVFYKM
                     WRQQKALAEEEETEELA"
     gene            15444..15914
                     /gene="nrdI"
                     /locus_tag="VVO18_001530"
     CDS             15444..15914
                     /gene="nrdI"
                     /locus_tag="VVO18_001530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000849618.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class Ib ribonucleoside-diphosphate reductase
                     assembly flavoprotein NrdI"
                     /protein_id="HEU5586657.1"
                     /translation="MKTISLVYISLSGNTESFVTRLKDYLLSQYKGIEVQKIHIKDLV
                     KEGKNFYEMDHPYVAFLPTYLEGGNGVDNGDVEILTTPVGDFIAYGNNASKCFGVVGS
                     GNRNFNNQYCLTAKQYSQRFGFPVLADFEMRGMLEDIKHVAAIIADLYELEKEN"
BASE COUNT         4607 a         2953 c         3526 g         4941 t
ORIGIN      
        1 tattgaaaag aattttgaac tatttacaaa acaaagtgat ctaattgttg caaatagatg
       61 ggataggggc cttgaagctt ataaagataa agtttacaca agggggatct ggataagaga
      121 ttaactattg atattaaaaa ggcaataatt tataaaattt gtacaaaaaa atgttaaatt
      181 ttcacatttt catagtatac tgtttaatag aaagtaggtt ctttgtaacc gctccattat
      241 aaaatccttt cactcttccg gtatactatt aggaaaaaca taactggagg atattttgag
      301 ctcacacctc atcgttccag tggctgttcc ccaagctcgt gtactgccca aaaaagttag
      361 acattctatt tagaacgagg attgagttct gtattgtaca aggctcggtc cttttagagt
      421 cagcttaagg ctggcttttt tgccctctta aatatcagaa tattttgaca aatgattgta
      481 aataatgata taatatgcaa aagctaggag gtggtcagat gattgagaga atggaactgg
      541 gggaatttta caaggaatta cgtttggcga gaaagcttaa gcagacagat gtggcttgtg
      601 agggtctaac agcttctcag ttgtccaagt ttgaactagg gcagtctatg ctgtctgcgg
      661 ataagttgat tctagctatc caaggtataa atgtgacctt tgatgagttt gggcacaagc
      721 tcaacaacta tcaagaatct ccacatatgc gaatcggtcg aaaggttgtg aatcgctttg
      781 cccatcagga tatagctgct ttagagcagc tattggagga agtcgatcaa gaacagatgg
      841 cgcagaccta tcgtcgtttg aatgccatcg tgattaaaga tgccatccat tcactaaata
      901 aaagctaccc actagcagag gaggatagcg agtttttgac cacctatctc tatgctatcg
      961 agtcttggac ctggtttgaa ctctatctct tttgcaatac catgcccttc ttgagcaatc
     1021 aagatctgat ttttttatca acctccttac tcgaaaaatc caaagaattt aaagagttag
     1081 tacacaatcg attgtatatg aagcaaggac tcttaaatat cttatcagaa ctcatggagc
     1141 gaaaactttt ctcctacatc ccaatcttcg aagccgagtt ggagaggatg ttacgaccgt
     1201 atgatgtttt tgaaaaagta tcgtggcaat ttttaaagaa gatgagtgtc tttcttcaaa
     1261 caaagggaag caatcaaaaa gagattgaac gctttatcca atctctgcag gtattagaaa
     1321 atccacaatt aacatccctt tttgaattgc gttttcagca atataaagaa cttatagatt
     1381 agttaaaaat ggaatgacaa taacccactc cgaaataagt aggagtatcg gttggatttt
     1441 tcttttcttc atctattata ttcctccttg ttagtaataa ctttattata ccagggaaat
     1501 aatcaaatct atcaaaatcg caaataagaa atttctataa gaaaaaatat caaatatgcg
     1561 attttttaaa ataagccaat tttcgtgtta tactgtactt gtaaagcact tgaagcaaat
     1621 cctaggtcgc agaagtggtt tacaaatgaa gataattgaa ggagtgtaaa agatgttaaa
     1681 tttacaattt gcagaaacaa tggaattgac agaagctgag ttggagacag tttatggagg
     1741 ggaatttggg aataatgctg ttatcccagc cggtgcttgg ggaggtttag gaacgtcttg
     1801 gtcaatcact aatttctgga agaaatattt taaccatgat tcttccactg ttaatcgtcg
     1861 ccattattga tattcagagt ccttgccttt ttcttgggta gggactgtct ttatttcata
     1921 gtataggaga aaatagaatg aaaaagataa tctcacaccg ctactttatt atagtttttc
     1981 tactagttat tgctgaccag aagttcagtg ttctagtttt acgcagcgac cttgttactg
     2041 ggctatctga ctttgcctat tatctgtcgg atatgatgtt gaattttctt gtggttttat
     2101 ttgctcttat tgctatgatt tggtcgggga aatggcagaa aatcaatagt agaaagttta
     2161 aaggatccta tcttttctat tccttcctag ctctgcttgc ttttgttgtt tggaatttcg
     2221 ttaccttttt tcttttccca cctactcgaa atgaaatttc ttatcaacat gctgctccga
     2281 cttttacagg ggctacagca tttttgatgt attttttcta tcctgtgatt gcaggtccca
     2341 tttttgaaga gataatccat cggggattgg tgatgacagc tctggaaaaa ggaaagaaat
     2401 gggggctaga tgtacttggt tctgctattt tatttggggt ctcgcacatt agtaatcacg
     2461 gttgggtctt gacagacttt gtcttctata tgggtggcgg acttatattt gtagtcttat
     2521 ttagaatgac aaagtccatt tattggccta ttgggctgca tatagtctac aacggcattg
     2581 gtcagctttt gatgttactg taattttggt tgttagtagt atcgcggtct attcttgggg
     2641 aaagattccc atttgaattt aaaaaggagt tgtaatgaaa gtatttcttc aaaatagaga
     2701 ttttaggcaa ttaactatca accagtggat ttcaacgctt ggggatacga ttttttatct
     2761 ggccttcctg aattatgtgg cagatgcgtc ttttgcccct ttggcgattt tacttatcac
     2821 gatttcagaa acccttcccc aagttctaca aatctttctg ggagttttgg cggattttca
     2881 acatcatcgt gtcttgaaat acacagtcat tagttttaca aaatttttgc tttactctat
     2941 agtgtcccta tcgctttcag ggcagtcttt ttccttgttg ctagtaacct ttatttgtct
     3001 gattaacctc ttgtctgaca cattgagtta cttttcagga gccatgctca ctccgatttt
     3061 cattagaatt attgggcaag accatctggc agaagctatt ggatttaaac agtcaactgt
     3121 tagtttagtg aaaacaatca gtaatattct aggaggagtc ttgctaggga ttctctccat
     3181 ccagttcatt tccttgctga acgctcttac ctttttaatc gcatttttag gtatcctctt
     3241 cataaaaact gacctcttga aagtagaaaa aacgattaac tatcaagaag gactctctgt
     3301 aaaatccttt tgccagcatt tgctccaatc atcgaaattg atatggaata tgaataaggt
     3361 gctcttggtt ttgtttatta tctctactag tcaagcagtg ataaatgtta cagttcctgt
     3421 ctctactcta tttttgagga atcaaccctt tttgaattta caaacaggtc aatctcttgc
     3481 cttgctatcc acttttgaac tgtcagccct gattgtcgga agccttgtaa gtggctatct
     3541 gcaacatacc atttccataa aaacagctct ctatgcctca cttgtcatcc agttgcttct
     3601 tctagtagga tttgccacag ttcgttttga ctggattctc atctttagta ccttggatgc
     3661 ctttttcgca ggtgttctct ctcctagatt gcaagaactc gtctttaaac aaatacctga
     3721 ggagtcaatg ggagcagttc aatcctctat cggtgccatt acggttgttt tacctagctt
     3781 atttacaata gctttggtaa ccattgctac tagctttgga actctggcag ttagctttgt
     3841 tttattgcta tttcttctag ttgcctttgt tatgcttctg aatattcgtg aaagtattta
     3901 gtggagaatt tctataatat atgtttgaga ctggattgcc agtcttttta tgatggtcaa
     3961 aatcaacaga cttttttctc ttttctgaat gtgttataat agactgaatc taaaatagta
     4021 cgaaacaatt gctaaaacat ttatagaaat taattttact ttcccaatcg atttgttctc
     4081 atcttatttc aatctgctat ataatagtcc atgctgtggc tggattcttt tcagcctact
     4141 tatactcttc gaaactctct tcaaaccacg tcagcttcac tttgccgtat atatgttact
     4201 gacttcgtca gttctatcca caacctcaaa acagtgtttt gagcaacctg cggctagttt
     4261 cctagtttgc tctttgattt tcattgagta ttattaagac aatatgagga gaaagatgaa
     4321 agaaaaagga ttttaggagg gggcgcaggc agccatgcca acggctcttg gctatgtcag
     4381 tatcggcctg gcctgtggga ctatcggtgc gccctatgtg acacctgttg agatgggctt
     4441 gatgagtctc tttgtttatg ctgggagtgc ccagtttgcc atgttggcac tgattgtggt
     4501 tcaagctcct gtggcagcta ttgctatgac ggtttttcta atcaacttgc gtctcttttt
     4561 gttgagttta cacgcatcga cttatttccg tcataccagt ctttggtaca atatcggtat
     4621 gtctagtatc ttgacagatg agacctatgg cgttttgatg ggtgaattgg cccatacaga
     4681 caaggtaaat cctatgtgga tgcacggaaa caatcttaac agctatgtgg cttggtttgt
     4741 ggggacagta gtcggaacgg ctctgggtgg cctgctacca aatccagaaa tctttggctt
     4801 ggattttgcc ctggttggga tgtttattgg tatttttgct tcgcaatttc agattatgca
     4861 aagacggatt cctgtccgca atctgctcat tatcctagca gttgttgcgg tgtccttctt
     4921 tttgctcttg acagtggtgt ctcagtcact agctgttctg tttgcgacgc tacttggttg
     4981 tagcatgggg gtggttttag atggtcagta agtatctttt attagcagtt attttctctg
     5041 gcttggtgac ttggattctc cgtatgattc ccttcatctt agtcaagtat aagggcttgc
     5101 ctgcaatcgt tgagcgtttt ttgaagttct tgcccgtttc cattatcttt gccttgattc
     5161 tttcaagcgt agtgacaggt aaggttggga gccttcctca aattaaatgg ctagacttct
     5221 tagccgtctt tccaacagct tgggtagcct ttcgctaccg caatctagtc ggaacagttc
     5281 tctttggagt ggtcttgatt gccatcttgc gtttggtctt ttaaattacc cataaaaaaa
     5341 acttatcaca gagatagata tcatataatg gcgtaaatgc tctttttctg ttaagattat
     5401 aaggtattct attttggagg aaatgacatg aaaaaaatcg ttaaatactc atctcttgct
     5461 gccctaggac ttgttgctgc aggtgtgctt gcggcttgct cagggggtgc taagaaagaa
     5521 ggagaagcag ctagcaagaa agaaatcatc gttgcaacca atggatcacc aaggccattt
     5581 atctatgaag aaaatggcga attgactggt tacgagattg aagtcgttcg cgctatcttt
     5641 aaagattctg acaaatatga tgtcaagttt gaaaagacag aatggtcagg tgtctttgct
     5701 ggtcttgacg ctgaccgtta caatatggct gtcaacaatc ttagctacac taaagaacgt
     5761 gcggagaaat acctctatgc cgcaccaatt gcccaaaatc ctaatgtcct tgtcgtgaag
     5821 aaagatgact ctagtatcaa gtctctcgat gatatcggtg gaaaatcgac ggaagtcgtt
     5881 caagccacta catcagctaa gcagttagaa gcatacaatg ctgaacacac ggacaaccca
     5941 actatcctta actatactaa ggcagacttc caacaaatca tggtacgttt gagcgatgga
     6001 caatttgact acaagatttt tgataaaatc ggtgttgaaa cagtgatcaa gaaccaaggt
     6061 ttggacaact tgaaagttat cgaacttcca agcgaccaac aaccgtacgt ttacccactt
     6121 cttgctcaag gtcaagatga gttgaaatca tttgtagaca aacgcatcaa agaactttat
     6181 aaagatggaa ctcttgaaaa attgtctaaa caattcttcg gagacactta tctaccggca
     6241 gaagctgata ttaaataatt tcttgaaatc atccattctg agtaaggtgg gtggtttctc
     6301 agtttttagg gatatagttt taaactatat atctgactat ctaataacaa tttgtgaaat
     6361 caaacaaatt gtgagatact agtacggtat tatttttaag gagaaagaat catgaaaatc
     6421 aaaaaatggc ttggcctagc agcccttgct acagtcgcag gtttggctct tgcagcttgc
     6481 ggaaactcag aaaagaaagc agacaatgca acaactatca aaatcgcaac tgttaaccgt
     6541 agcggttctg aagaaaaacg ttgggacaaa atccaagaat tggttaaaaa agacggaatt
     6601 accttggaat ttacagagtt cacagactac tcacaaccaa acaaagcaac tgctgatggc
     6661 gaagtagatt tgaacgcttt ccaacattat aacttcttga acaactggaa caaagaaaac
     6721 ggaaaagacc ttgtagcgat tgcagatact tacatctctc caatccgcct ttactcaggt
     6781 ttgaatggaa gtgccaacaa gtacactaaa gtagaagaca tcccagcaaa cggagaaatc
     6841 gctgtaccga atgacgctac aaacgaaagc cgtgcgcttt atttgcttca atcagctggc
     6901 ttgattaaat tggatgtttc tggaactgct cttgcaacag ttgccaacat caaagaaaat
     6961 ccaaagaact tgaaaatcac tgaattggac gctagccaaa cagctcgttc attgtcatca
     7021 gttgacgctg ccgttgtaaa caataccttc gttacagaag caaaattgga ctacaagaaa
     7081 gcacttttca aagaacaagc tgatgaaaac tcaaaacaat ggtacaacat cattgttgca
     7141 aaaaaagatt gggaaacatc acctaaggct gatgctatca agaaagtaat cgcagcttac
     7201 cacacagatg acgtgaaaaa agttatcgaa gaatcatcag atggtttgga tcaaccagtt
     7261 tggtaataag aaacagggag gtgggagaga aaattccacc tcttgctttt gtatagagta
     7321 tagattgtaa agaagactat tcgttcatag aaaggtagag agaatatggt ttttcctagc
     7381 gaacaagaac agattgaaaa atttgaaaag gatcatgtag cccagcatta ttttgaggtt
     7441 ttgcgtacct tgatttctaa gaaatcagtc tttgcccagc aggttggact caaggaagtc
     7501 gcaaattatc tgggtgagat tttcaagcgt gttggagctg aagtggagat tgatgagagc
     7561 tatacagcgc cctttgtcat ggcacatttc aagagttcgc gtccagatgc caagaccttg
     7621 attttctata accactatga cactgtgcca gcggatgggg atcaggtctg gacagaggat
     7681 ccttttacgc tttcggtccg caatggcttc atgtatgggc gtggggttga tgacgacaag
     7741 ggtcatatca cagctcgctt gagtgctttg agaaaatata tgcagcacca tgatgattta
     7801 cctgtcaata tcagctttat catggaggga gcggaggaat cggcttcaac agacctagat
     7861 aagtatttgg aaaagcatgc agacaaactc cgtggggcgg atttgttggt ctgggaacaa
     7921 gggaccaaaa atgccttgga acagctggaa atttctggtg gcaataaggg gattgtgacc
     7981 tttgatgcca aggtaaaaag cgctgatgtg gatatccact cgagttatgg tggtgttgtg
     8041 gaatcagctc cttggtatct cctccaagcc ttacagtctc ttcgtgctgc ggatggccgt
     8101 atcttggttg aaggcttgta cgaagaagta caagagccca atgaacgaga aatggccttg
     8161 ctagaaactt atggtcaacg aaacccagag gaagttagtc ggatttatgg attggagttg
     8221 cctctcttac aggaggagcg gatggccttt ctaaaacgtt tctttttcga tccagcgctt
     8281 aatatcgaag gaatccagtc tggttatcaa ggtcagggtg ttaagactat tttacctgca
     8341 gaagccagtg ccaagctaga ggttcgtctg gttccgggcc tagaaccgca tgatgttctg
     8401 gaaaaaattc ggaaacagct agacaaaaat ggctttgata aggtagaatt atactatacc
     8461 ttgggagaga tgagctatcg aagcgatatg agcgcaccag ccattctcaa tgtgatcgag
     8521 ttggccaaga aattctatcc acagggcgtt tcagtcttgc cgacgacagc ggggacagga
     8581 cctatgcata cggtctttga tgccctagag gtaccaatgg ttgcattcgg tctaggaaat
     8641 gccaatagcc gagaccacgg tggagatgaa aatgtgcgaa tcgctgatta ttacacccat
     8701 atcgaattag tagaggagct gattagaagc tatgagtaga gatattatca agttagatca
     8761 gatcgatgtg acttttcacc aaaagaagag aaccatcaca gcggttaagg atgtgaccat
     8821 tcacatccaa gaaggggata tctacggaat cgttggatat tctggagcag gaaaatcaac
     8881 ccttgtacgg gtgattaatc tcttgcaaaa accatctgca gggaaaatta ccattgacga
     8941 cgatgtgatt tttgacggca aggtgacctt gacggcagag cagttgcgtc gtaaacgtca
     9001 agatatcgga atgattttcc agcattttaa cctgatgagc caaaagacag cagaggagaa
     9061 tgtagccttt gcccttaaac actctgaact cagcaaggaa gaaaagaagg ctaaagtagc
     9121 taagttgttg gacttggttg gtttggcaga tcgtgctgaa aactaccctt cacaactatc
     9181 tggagggcaa aaacagcgtg tggcaattgc gcgtgccttg gccaatgatc caaaaatctt
     9241 gatttcagac gagtcaactt ctgcccttga tccgaagaca accaagcaga ttttggcctt
     9301 gttgcaagat ttgaaccaaa aattaggctt gactgttgtc ttgattacgc atgaaatgca
     9361 gattgtcaaa gacattgcca accgtgtggc ggttatgcag gatgggcatt tgattgaaga
     9421 gggtagtgtg cttgaaatct tctcagaccc taaacaacct ttgactcaag actttatctc
     9481 aacagccaca ggtattgacg aagccatggc caaaatcgag aagcaagaaa tcgtggaaca
     9541 cttgtctgaa aacagtctct tggtgcaact caagtacgct ggagcttcaa cagacgagcc
     9601 acttttgaat gaattgtaca agcattacca agtaatggct aatattctct atgggaatat
     9661 cgaaattctc gatggtactc ctgttggaga attggtgttg gtcttgtcag gtgaaaaagc
     9721 agcgttggca ggtgcccaag aagccattcg tcaagcaggt gtacaactaa aagtattgaa
     9781 gggagtacag taagatggaa tcattgattc aaacctattt accaaatgtc tataaaatgg
     9841 gttgggctgg tcaggcaggc tggggaacgg ctatctactt aactctttat atgacagttc
     9901 tttccttcat tatcggaggc ttcttggggc tagtggcagg tctctttctc gtcttgacag
     9961 cgccaggtgg tgtcttggag aataaagtcg tattctggat tttagacaaa attacctcaa
    10021 tttttcgtgc ggttcccttt atcatcctct tggcaatctt gtcaccactt tctcacttga
    10081 ttgttaaaac aagtatcggg ccaaatgcag cccttgtccc actttctttt gcagtctttg
    10141 ccttctttgc ccgtcaggtg caggttgtct tggctgaatt ggatggcggt gtcattgagg
    10201 cggctcaagc gagcggagcg actttctggg acatcgtggg tgtttaccta tcagaaggtc
    10261 ttccagattt gatccgtgtg acgactgtga ccttgatttc ccttgttggg gaaacagcta
    10321 tggccggtgc ggttggagct ggtggtatcg gtaacgtagc catcgcttat ggatttaacc
    10381 gctacaatca cgatgtgacc atcttggcaa ccatcattat cattttgatt atctttgcaa
    10441 tccaattctt gggagatttc ttgactaaga aattgagcca taaataaaaa agagccgtgt
    10501 ggctcttttt aactgatcag attttctgtg caaatttttt actcaaggct tgtccaatca
    10561 aggcacccac tagggctccg atgacaatac ttgcgataaa tagaaggaca gttccagggg
    10621 ttggagcgac catgatacgg tcgatatatt cttgggattt tcctcttgcc agaagagtag
    10681 ccatataggc tttgggcgca atccacataa gcaagattgg tcctgttgta ctaaaggcga
    10741 aaataatgaa agaaaggaag ttctttgttt tgtccttgta ttttcctaaa tgagctactt
    10801 catctgctag gaggccacag ataattccag gaaggaagga accagcaccg tgtttagttc
    10861 ccaagaaaaa gaaggcaatg acaaggccga tagtggtaat ggctccaaag cgcggaactt
    10921 ttgcgactag gatcatatag acgctaccgc cgacaagggc agtaaaggca ggcgcataaa
    10981 acatgtttcc agtttggtca aagagattgc ccaaaaggac accaatcccc atgcagagga
    11041 agtaaagaac tgcaaaaagc agtgtagtta agatagattt tttcatgaat tgtctcctga
    11101 taattttttc acaattctca ttgtaccacg gtttggtggg attgtaaatg gatactagaa
    11161 gtttttgaaa acgcttgaaa tatgatataa tggtttcata gttattttta ggggaatatc
    11221 atgggtagat ttttagactt tgtctttaat cgtttctttt tagggatgat tgcgacagcc
    11281 ttcttttggc tattaacttt agcaggaggg attatccttg gtctagcgcc ggctagtgcc
    11341 accttgatga gcttatatgc agaacatggt tatagctttc gggaatacag tttgaaggag
    11401 gcttggtctc tttacaagca aaattttgtc tcaagcaacc tgattttcta tagcttttta
    11461 ggtgtgggtc tagttttgac ctatggtttg tatctcttgg tgcaattgcc tcatcagacc
    11521 attgttcatt tgattgcgac ccttttgaat gtcctagtag ttgccctgat ctttttggct
    11581 tatacagtat ctttaaaatt acaagtttat tttgccttgt cctatcgaaa tagtctcaaa
    11641 ttatccttga ttggcatctt tatgagtcta gcagctgtgg ctaaggttct ccttgggact
    11701 gtgctacttg tagcaattgg ttattatatg cctgccctgc tattttttgt aggaattggg
    11761 atgtggcatt tctttatcag tgatatgttg gaacctgtct atgaaatcat ccatgaaaaa
    11821 ttggcgacaa aatagaatga agcagttttg gctacatacg cttctaagaa cctatagttc
    11881 agtgatgatc attatcattg cgagttttgc aatcttactc tcttacgctg actgggattc
    11941 acgtgaaaag gaagcccaga gagtagccca gcgtgtaact gctagaacag tgagtgaaat
    12001 tgaatattac catagagagt caacccagat agctcaggct ttagttgaaa atcaagctcg
    12061 tattgaggga atctataaat actttagcct tagcatgcca gactattttt actggcaatt
    12121 agagcggaaa gcttcgcctt atatatcagt ctctctgtat gaaaatgttg atgacctcta
    12181 tgttcgaaat gattttgtaa ctggagtggc cattgctttt caagattaca aggaagtcta
    12241 tgtttctact aaagacaaac gtagtggaga aaaaatcagg gctgaggatt tcaaaccagc
    12301 aggaaatagt tttgccattc cggtgtcaga tccagtgtca gatcaagatt taggagtgat
    12361 ttacatctcc ttgaatcctg ctgttttata ccatgccatt gataatacta gaggtcatac
    12421 tccgatggca gtaacagtga cctcaccttt tgatacggag atttttcata ttggtgagac
    12481 agttgatagg gagagtgaaa attggctagt tggcttaact tctcatggat atcaggttca
    12541 ggtggcagtt cctaaaaact ttgttttaca aggaacagtg actagctctg ctttgattgt
    12601 gggtttgagc cttctcttta ttgtcattct ttatctgact ttgaggcaga cttttgctaa
    12661 ttaccaaaag caggtagtgg atttagtgga atccattcaa gtcattgctc aaggcgaaga
    12721 ggggcgtcgg attgacattt ccgaaaaaga tcaggaatta ctcctaatcg cggagacgac
    12781 caatgatatg ttggatcgat tggaaaagaa tatccatgat atttaccagt tagagcttag
    12841 tcaaaaagat gccaatatgc gagccttgca ggcgcaaatc aatcctcatt ttatgtataa
    12901 tacgctggag ttcttgcgca tgtatgcagt tatgcagagt caagatgagt tggcagatat
    12961 catttatgaa ttcagtagtc tcttgcgtaa caatatttcc gacgaaagag agaccctcct
    13021 caaacaggaa ttagaatttt gccgtaaata cagctatctc tgcatggttc gctatcccaa
    13081 gtccattgcc tatggtttca agatagatcc agagttagag aatatgaaga ttcccaagtt
    13141 taccttgcaa ccgctggtag aaaactattt cgcgcatggt gttgaccaca ggcggacaga
    13201 taatgtgatt agcatcaagg ctcttaaaca ggatggtttt gtggaaattt tggtggtcga
    13261 taatggtaga ggaatgtcgg ctgaaaagct ggcaaatatc cgagaaaaat taagtcagag
    13321 aaactttgaa caccaagcca gctacagtga tcaaaggcag tctatcggaa ttatcaatgt
    13381 acacgagcgt tttgtgctct attttggaga ccgctatgcc attactatag agtctgcaga
    13441 gcaagccggt gttcagtatc gtattacaat tcaagatgag tagaaaggga gaaaatgtat
    13501 aaagtattat tagtagatga tgagtacatg gtgacagaag gtctgaagcg tttgattccc
    13561 tttgataagt gggatatgga ggtcgtcgca acagtcagtc atgccgatga agctctagaa
    13621 tatgttcagg aaaatcctgt cgatgtcatc atttccgatg tcaatatgcc agacaaaaca
    13681 gggcttgata tgattcggga gatgaaagag atcttaccag atgctgccta tatcctgctc
    13741 tcaggttatc aggagtttga ttatgtaaaa agagcaatga accttagtgt ggtggactat
    13801 ttggtcaaac ctgttgataa ggtagagctg ggaaatctgc tggagaagat tgcaggtcag
    13861 ctcggcgaga gagggaagaa aagtcagact cttagtcaag aattagacga ggctgaattt
    13921 gttagttatt taggggataa ggagaattgg tggataggtc tatccaagga aaaacaaggt
    13981 tccttcacca ttccctacta tgtcttgggt caagcctggc agattttcat ttctgaccaa
    14041 cccctagatg gtttagtcgt tacacctttt gaagctcctt atcaagaaca ttttgaacgc
    14101 tggaagctga atgctgagaa aaccctcttt tacggttctg taaatctgca gcagtctgag
    14161 agtctctttg cctattacga accgatttat agggttatca ttcagggaaa tctcaatcaa
    14221 atcgtagaag agttaaatct cttggagaag gtagttcttg aaaatacgcc gcgaattccg
    14281 attactaaac agctttttat ccagtttgtc atggatgtct tccatttatt tgaacatctc
    14341 aaagctgatg atatgacgga cattgtcaaa accattcatg ctattcaatc cttcgatgaa
    14401 ttggtttctt atatcaagga aactctgatc agctttttcg gtcaataccg tatgaatgaa
    14461 aatgtggtca gtgtgctgga agtcattggt cgtgattacc aaaaagagct ttccctcaag
    14521 gatatcagta aggccctctt tatcaatcct gtctatctag ggcagttgat taagcgtgaa
    14581 accgattcga cctttgcaga gttactaaac aaacaacgta ttaaggctgc ccagcagctc
    14641 ttgctttcaa ccagtgacag tatcgaagat atttgttatg ctgttggtta cagtaacctt
    14701 ggatatttct ataaagtttt ccgaaaattg tgcggaaaat cgccaaaagc ctaccgaaaa
    14761 caggtagaaa ctatactata agatttgtat tcctttacaa aaggtgctat aatattatca
    14821 ggaggtccta tcatgaaaaa gaaaccaatt tatctatggg tcttgctaat cttgtctgcc
    14881 cttatttcag ttccgtctct gtttggaatt gtgagtccct tgcctagtaa agaagccctt
    14941 cgtgctgctc agaaacaagt tgcaggggtc aatgctcagc aattagaaga ccagcttaat
    15001 tatacctata gagtagcaga agcatctcat tctattttta atgttgcttt gattgtgcta
    15061 tctactattt tagtggtcgt agcgattgtc ttccttgttc gtaaaaattt gcaatatgca
    15121 aactatactt acgttggcta tgttttgtta gctattattg gttcgattta tggctatgtt
    15181 ggtttacaag acgctgtgca gttggttcaa gatgagagca tgcgtttgac agtgagtatt
    15241 ggttcaaaag ctgttagcat tttctatatc gtcatcaatg ttctcttcct agcccttgtc
    15301 ttctataaga tgtggcgaca acagaaagcc ttggcagaag aagaggaaac agaagagctt
    15361 gcctaagtat tgacaaaaaa gaactatcaa gatacaatct tggtagttgt tttttgatta
    15421 tagataaaat catggaggta catatgaaga caatttcttt agtttatatt agtttgagtg
    15481 gcaacactga aagttttgtg acgcgcttga aagactatct cttgtcccag tacaaaggga
    15541 ttgaggttca aaagattcat atcaaggatt tggtcaagga aggcaaaaat ttctatgaaa
    15601 tggaccatcc ctatgtcgct tttttgccga cctatctcga aggtgggaat ggcgtggata
    15661 acggagatgt tgagattttg acgacaccgg tgggagattt tattgcctat ggtaacaatg
    15721 ctagtaagtg ttttggtgtg gttgggtcag gaaatcgtaa ctttaataac caatactgcc
    15781 taacagccaa gcaatacagt caacgctttg gcttccctgt attggctgac tttgaaatgc
    15841 gaggcatgct ggaagatatc aaacatgtcg cagctattat cgcagatttg tatgagttgg
    15901 aaaaggagaa ttaatactca atgaaaatca aagagcaaac taggaagcta gtcgcaggtt
    15961 gctcaaagca cagctttgag gttgcagata gagctgacgt ggtttgaaga gattctcgaa
    16021 tagtata
//
LOCUS       DAVHIZ010000043        14766 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.045, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000043 DAVHIZ010000000
VERSION     DAVHIZ010000043.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14766)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14766)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14766
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.045"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            78..2198
                     /gene="pspA"
                     /locus_tag="VVO18_001531"
     CDS             78..2198
                     /gene="pspA"
                     /locus_tag="VVO18_001531"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001035384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein A"
                     /protein_id="HEU5586658.1"
                     /translation="MNKKKMILTSLASVAILGAGFVTSQPTVVRAEESPVASQSKAEK
                     DYDAAVKKSEAAKKHYEEAKKKAEDAQKKYDEDQKKTEAKAEKERKASEKIAEATKEV
                     QQAYLAYLQASNESQRKEADKKIKEATQRKDEAEAAFATIRTTIVVPEPSELAETKKK
                     AEEAKAEEKVAKRKYDYATLKLALAKKEVEAKELEIEKLQYEISTLEQEVATAQHQVD
                     NLKKLLAGADPDDGTEVIEAKLKKGEAELNAKQAELAKKQTELEKLLDSLDPEGKTQD
                     ELDKEAEEAELDKKADELQNKVADLEKEISNLEILLGGADPEDDTAALQNKLAAKKAE
                     LAKKQTELEKLLDSLDPEGKTQDELDKEAEEAELDKKADELQNKVADLEKEISNLEIL
                     LGGADSEDDTAALQNKLATKKAELEKTQKELDAALNELGPDGDEEETPAPAPQPEQPA
                     PAPKPEQPAPAPKPEQPAKPEKPAEEPTQPEKPATPKTGWKQENGMWYFYNTDGSMAT
                     GWLQNNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNSNGA
                     MATGWLQYNGSWYYLNANGDMATGWLQYNGSWYYLNANGDMATGWAKVNGSWYYLNAN
                     GAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYV
                     NGLGALAVNTTVDGYKVNANGEWV"
     gene            2599..3720
                     /gene="mnmA"
                     /locus_tag="VVO18_001532"
     CDS             2599..3720
                     /gene="mnmA"
                     /locus_tag="VVO18_001532"
                     /EC_number="2.8.1.13"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006153390.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA 2-thiouridine(34) synthase MnmA"
                     /protein_id="HEU5586659.1"
                     /translation="MSDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDT
                     DENGVCTATEDYKDVVAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVM
                     CNKEIKFKAFLDYAITLGADYVATGHYARVARDEDGTVHMLRGVDNGKDQTYFLSQLS
                     QEQLQKTMFPLGHLEKPEVRRLAEEAGLSTAKKKDSTGICFIGEKNFKNFLSNYLPAQ
                     PGRMMTVDGRDMGEHAGLMYYTIGQRGGLGIGGQHGGDNAPWFVVGKDLSKNILYVGQ
                     GFYHDSLMSTSLEASQVHFTREMPEEFTLECTAKFRYRQPDSKVTVHVKGEKTEVIFA
                     EPQRAITPGQAVVFYDGEECLGGGLIDNAYRDGQVCQYI"
     gene            3861..4316
                     /locus_tag="VVO18_001533"
     CDS             3861..4316
                     /locus_tag="VVO18_001533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398431.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU5586660.1"
                     /translation="MTQQDFRTKVDNTVFGVRATALIVQNHKLLVTKDKGKYYTIGGA
                     IQVNESTEDAVVREVKEELGVKAQAGQLAFVVENRFEVDGVSYHNIEFHYLVDLLEDA
                     PLTMQEDEKRQPCEWIDLDKLQNIQLVPAFLKTALPDWEGQLRHIHLEE"
     gene            4326..6239
                     /gene="mnmG"
                     /locus_tag="VVO18_001534"
     CDS             4326..6239
                     /gene="mnmG"
                     /locus_tag="VVO18_001534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221902.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="HEU5586661.1"
                     /translation="MTYHFTEEYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEML
                     AFMPCNPSIGGSAKGIVVREVDALGGEMAKTIDKTYIQMKMLNTGKGPAVRALRAQAD
                     KELYSKEMRKTVENQENLTLRQTMIDEILVEDGKVVGVRTATHQEYAAKAVIVTTGTA
                     LRGEIIIGDLKYSSGPNHSLASINLADNLKELGLEIGRFKTGTPPRVKASSINYDVTE
                     IQPGDEVPNHFSYTSRDEDYVKDQVPCWLTYTNGTSHEIIQNNLHRAPMFTGVVKGVG
                     PRYCPSIEDKIVRFADKERHQLFLEPEGRNTEEVYVQGLSTSLPEDVQRDLVHSIKGL
                     ENAEMMRTGYAIEYDMVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGI
                     NAALKIQGKPELILKRSDGYIGVMIDDLVTKGTIEPYRLLTSRAEYRLILRHDNADMR
                     LTEMGREIGLVDDERWARFEIKKNQFDNEMKRLDSIKLKPVKETNAKVEEMGFKPLTD
                     AVTAKEFLRRPEVSYQDVVAFIGPAAEDLDDKIIELIETEIKYEGYISKAMDQVAKMK
                     RMEEKRIPANIDWDDIDSIATEARQKFKLINPETIGQASRISGVNPADISILMVYLEG
                     KNRSISKTLQKSK"
     gene            complement(6446..6538)
                     /locus_tag="VVO18_001535"
                     /pseudo
     CDS             complement(6446..6538)
                     /locus_tag="VVO18_001535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(6592..8271)
                     /locus_tag="VVO18_001536"
     CDS             complement(6592..8271)
                     /locus_tag="VVO18_001536"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009729634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease J"
                     /protein_id="HEU5586662.1"
                     /translation="MAYTLKPEEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFP
                     EDDLLGIDYVIPDYSYIVDNIDRVKAVLITHGHEDHIGGIPFLLKQANVPIYAGPLAL
                     ALIRGKLEEHGLLRNAKLYEINHNTELTFKNLKATFFRTTHSIPEPLGIVIHTPQGKI
                     VCTGDFKFDFTPVGEPADLHRMAALGEEGVLCLLSDSTNAEVPTFTNSEKVVGQSIMK
                     IIQGIEGRIIFASFASNIFRLQQATEAAVKTGRKIAVFGRSMEKAIVNGIDLGYIKAP
                     KGTFIEPNEIKDYPAGEVLILCTGSQGEPMAALSRIANGTHRQVQLQPGDTVIFSSSP
                     IPGNTTSVNKLINIISEAGVEVIHGKVNNIHTSGHGGQQEQKLMLRLIKPKYFMPVHG
                     EYRMQKVHAGLAVDTGVEKDNIFIMSNGDVLALTADSARIAGHFNAQDIYVDGNRIGE
                     IGAAVLKDRRDLSEDGVVLAVATVDFKSQMILSGPDILSRGFVYMRESGDLIRQSQRI
                     LFNAIRIALKNKDASVQSVNGAIVNAIRPFLYENTEREPIIIPMILTPDEE"
     gene            complement(8273..8506)
                     /locus_tag="VVO18_001537"
     CDS             complement(8273..8506)
                     /locus_tag="VVO18_001537"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002947111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-dependent RNA polymerase auxiliary subunit
                     epsilon family protein"
                     /protein_id="HEU5586663.1"
                     /translation="MIYKVFYQETKERSPRRETTRTLYLDIDASSELEGRITARQLVE
                     ENRPEYNIEYIELLSDKLLDYEKETGAFEITEF"
     gene            8786..9001
                     /locus_tag="VVO18_001538"
     CDS             8786..9001
                     /locus_tag="VVO18_001538"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000282487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586664.1"
                     /translation="MYNLFAFAIGARLVAFIVFVACVYAGNLLFAKLERRQTKFLWKM
                     TFVTLYSLFLLLVTYVVWFVFYFELNA"
     gene            complement(9324..9476)
                     /gene="cibB"
                     /locus_tag="VVO18_001539"
     CDS             complement(9324..9476)
                     /gene="cibB"
                     /locus_tag="VVO18_001539"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibB"
                     /protein_id="HEU5586665.1"
                     /translation="MMKDLNNYREISNKELQEIKGGFGVGVGIALFMAGYTIGKDLRK
                     KFGKSC"
     gene            complement(9478..9663)
                     /gene="cibA"
                     /locus_tag="VVO18_001540"
     CDS             complement(9478..9663)
                     /gene="cibA"
                     /locus_tag="VVO18_001540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000180803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fratricide two-peptide bacteriocin subunit CibA"
                     /protein_id="HEU5586666.1"
                     /translation="MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGG
                     TALIGSGLAAGYFLGGD"
     gene            9841..10524
                     /gene="tsaB"
                     /locus_tag="VVO18_001541"
     CDS             9841..10524
                     /gene="tsaB"
                     /locus_tag="VVO18_001541"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865689.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="HEU5586667.1"
                     /translation="MKVLAFDTSSKALSLAILEDKQVLAETTINIKKNHSITLMPAID
                     FLMASLDWTPKDLDRIVVAEGPGSYTGLRIAVATAKTLAYTLNIELVGMSSLLALVPH
                     QQEGLFVPLMDARRNNVYAGFYENAKPVMAEAHLSFEEVLEKVKGTSQVTFVGEVGPF
                     VEQIQKHLPRTDYKETLPNAANLALLAWDKEADSLHDFVPNYLKRVEAEENWLKNHTE
                     SGESYIKRL"
     gene            10521..10958
                     /gene="rimI"
                     /locus_tag="VVO18_001542"
     CDS             10521..10958
                     /gene="rimI"
                     /locus_tag="VVO18_001542"
                     /EC_number="2.3.1.266"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569806.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="HEU5586668.1"
                     /translation="MIEIKRIQQQPDLAQAIYAVMAAVYLVSPWTLEQIQADLSQDQT
                     WYALAYDGAEVIGFLAVQENLFEAEVLQIAVKGAYQGQGIASALFAQLPTDKEIFLEV
                     RQSNQRAQAFYKKEKMAVIAERKAYYHDPVEDAIIMKREIDEG"
     gene            10948..11958
                     /gene="tsaD"
                     /locus_tag="VVO18_001543"
     CDS             10948..11958
                     /gene="tsaD"
                     /locus_tag="VVO18_001543"
                     /EC_number="2.3.1.234"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002896630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="HEU5586669.1"
                     /translation="MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGG
                     VVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKTFA
                     WAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETR
                     DDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSA
                     FINLYHNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANK
                     GLRERLAAEITDVKVIIPPLRLCGDNAGMIAYASVSEWNKENFAGWDLNAKPSLAFDT
                     ME"
     gene            complement(11998..13304)
                     /locus_tag="VVO18_001544"
                     /pseudo
     CDS             complement(11998..13304)
                     /locus_tag="VVO18_001544"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011680908.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(13580..13931)
                     /locus_tag="VVO18_001545"
                     /pseudo
     CDS             complement(13580..13931)
                     /locus_tag="VVO18_001545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(14038..14331)
                     /locus_tag="VVO18_001546"
                     /pseudo
     CDS             complement(14038..14331)
                     /locus_tag="VVO18_001546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT         4393 a         2882 c         3431 g         4060 t
ORIGIN      
        1 gacaaatatt tacggggggg ggtatactta atataagtat aatctaaaaa tgattatcag
       61 aaaagaggta aatttagatg aataagaaaa aaatgatttt aacaagtcta gccagcgtcg
      121 ctatcttagg ggctggtttt gttacgtctc agcctactgt tgtaagagca gaagaatctc
      181 ccgtagccag tcagtctaaa gctgagaaag actatgatgc agcagtgaaa aaatctgaag
      241 ctgctaagaa acattacgaa gaagctaaaa agaaagcaga agacgctcag aaaaaatatg
      301 atgaggatca gaagaaaact gaggcaaaag cggaaaaaga aagaaaagct tctgaaaaga
      361 tagctgaggc aacaaaagaa gttcaacaag cgtacctagc ttatctacaa gctagcaacg
      421 aaagtcagag aaaagaggca gataagaaga taaaagaagc tacgcaacgc aaagatgagg
      481 cggaagctgc atttgctact attcgaacaa caattgtagt tcctgaacca agtgagttag
      541 ctgagactaa gaaaaaagca gaagaagcta aagcagaaga aaaagtagct aagagaaaat
      601 atgattatgc aactctaaag ctagcactag cgaagaaaga agtagaggct aaggaacttg
      661 aaattgaaaa acttcaatat gaaatttcta ctttggaaca agaagttgct actgctcaac
      721 atcaagtaga taatttgaaa aaacttcttg ctggtgcgga tcctgatgat ggcacagaag
      781 ttatagaagc taaattaaaa aaaggagaag ctgagctaaa cgctaaacaa gctgagttag
      841 caaaaaaaca aacagaactt gaaaaacttc ttgacagcct tgatcctgaa ggtaagactc
      901 aggatgaatt agataaagaa gcagaagaag ctgagttgga taaaaaagct gatgaacttc
      961 aaaataaagt tgctgattta gaaaaagaaa ttagtaacct tgaaatatta cttggagggg
     1021 ctgatcctga agatgatact gctgctcttc aaaataaatt agctgctaaa aaagctgagt
     1081 tagcaaaaaa acaaacagaa cttgaaaaac ttcttgacag ccttgatcct gaaggtaaga
     1141 ctcaggatga attagataaa gaagcagaag aagctgagtt ggataaaaaa gctgatgaac
     1201 ttcaaaataa agttgctgac ttagaaaaag aaattagtaa ccttgaaata ttacttggag
     1261 gggctgattc tgaagatgat actgctgctc ttcaaaataa attagctact aaaaaagctg
     1321 aattggaaaa aactcaaaaa gaattagatg cagctcttaa tgagttaggc cctgatggag
     1381 atgaagaaga aactccagcg ccggctcctc aaccagagca accagctcct gcaccaaaac
     1441 cagagcaacc agctccagct ccaaaaccag agcaaccagc taagccggag aaaccagctg
     1501 aagagcctac tcaaccagaa aaaccagcca ctccaaaaac aggctggaaa caagaaaacg
     1561 gtatgtggta tttctacaat actgatggtt caatggcaac aggttggctc caaaacaacg
     1621 gttcatggta ctacctaaac gctaacggtt caatggcaac aggttgggtg aaagatggag
     1681 atacctggta ctatcttgaa gcatcaggtg ctatgaaagc aagccaatgg ttcaaagtat
     1741 cagataaatg gtactatgtc aacagcaatg gcgctatggc gacaggctgg ctccaataca
     1801 atggctcatg gtactacctc aacgctaatg gtgatatggc gacaggctgg ctccaataca
     1861 acggttcatg gtattacctc aacgctaatg gtgatatggc gacaggctgg gctaaagtca
     1921 acggttcatg gtactaccta aacgctaacg gtgctatggc tacaggttgg gctaaagtca
     1981 acggttcatg gtattacctc aacgctaacg gttcaatggc aacaggttgg gtgaaagatg
     2041 gagatacctg gtactatctt gaagcatcag gtgctatgaa agcaagccaa tggttcaaag
     2101 tatcagataa atggtactat gtcaatggct taggtgccct tgcagtcaac acaactgtag
     2161 atggctataa agtcaatgcc aatggtgaat gggtttaagc cgattaaatt aaatcatgtt
     2221 aagaacattt gacattttaa ttttgaaaca aagataaggt tcgattgaat agatttatgt
     2281 tcgtattctt taggtaccta tcttatgatt tcaggaaatg tcattaaaaa aacgactcct
     2341 tttctctaac ttgaaaaata gattagagaa aatgggttgt tttatttatt atagttattt
     2401 gaatgaagat aagaagaagg tatactcaca tcattcacat aatctgtata ttgactataa
     2461 gttttaaaaa acaattttta agctcttcct tgtcttctct aaccaagcgt gttataatga
     2521 atactgctca agcgaccttc aatcgtgaag cacacacgac cttcaatcgt gaataaacga
     2581 atagatggga gacttaccat gagtgataac tctaaaacac gtgttgtcgt ggggatgagt
     2641 ggtggtgttg attcgtcggt gacggctctt ttgctcaagg agcagggcta cgatgtgatc
     2701 ggtatcttca tgaagaactg ggatgacaca gatgaaaacg gcgtctgtac ggcgaccgaa
     2761 gattacaagg atgtggttgc ggtggcagac cagattggca ttccctacta ctctgtcaat
     2821 tttgaaaaag agtactggga ccgcgttttt gagtatttcc tagcggaata ccgtgcaggg
     2881 cgcacgccaa atccggacgt tatgtgcaac aaggaaatca agttcaaggc ctttttggac
     2941 tatgccataa ccttgggggc agactatgta gcgactgggc attatgctcg agtggcgcgt
     3001 gatgaggatg gtaccgttca catgcttcgt ggcgtggaca atggcaagga tcagacctat
     3061 ttcctcagcc aactttcgca agaacaactt caaaaaacca tgttcccact aggacatttg
     3121 gaaaagcctg aagtacgcag actagcagaa gaagcaggcc tttcgactgc taagaagaaa
     3181 gactcgacag ggatttgctt tatcggagaa aagaacttta aaaactttct cagcaactac
     3241 ctgccagctc agcctggtcg catgatgact gtggatggtc gcgatatggg cgagcatgca
     3301 ggtcttatgt actatacaat cggtcagcgt ggcggactcg gtatcggtgg gcaacacggc
     3361 ggtgacaatg ccccttggtt cgttgtcgga aaagatctaa gcaagaatat tctctatgta
     3421 ggacaaggat tctaccatga ttcgctcatg tcaactagcc tagaagccag tcaagtccac
     3481 tttactcgtg aaatgccaga agagtttacg ctagaatgta cggctaaatt ccgttaccgt
     3541 cagcctgact ctaaggtgac cgttcatgtc aaaggagaaa agacagaggt catctttgcg
     3601 gaaccacaac gcgcgattac accaggacag gcagttgtct tttacgatgg cgaagagtgt
     3661 ctaggtggcg gtttgattga caatgcttac cgcgatggac aagtttgtca gtacatttag
     3721 attgacaaat tttctcaatt tgctacaata ataacagcaa tagaaatgat ggtcaaagct
     3781 catggatgtt gcaggctttt ttgtcctgca cttctttgta gttttgactg tttttgtgtc
     3841 gtttaaggga aaggacaaga atgactcaac aagactttcg gacaaaagta gacaatacgg
     3901 tttttggtgt tcgggctaca gccttgattg tccaaaatca caagcttcta gttaccaaag
     3961 acaagggcaa gtattacact attggaggtg cgattcaagt caatgaaagc acggaagacg
     4021 cggtagtccg tgaagtgaag gaagaactgg gtgtcaaagc tcaagctggg cagctagctt
     4081 ttgtggttga aaatcgtttt gaagtggacg gcgtttccta tcacaatatc gagtttcatt
     4141 atctggtgga tttgcttgaa gatgccccgt tgaccatgca ggaagatgag aaaaggcagc
     4201 cctgtgagtg gattgacttg gataagctcc agaatatcca gctagttcca gcctttttaa
     4261 aaacagccct accagattgg gaaggccaac taagacacat tcatcttgag gaataggaga
     4321 gaaacatgac ttatcatttt actgaagaat acgatattat tgtaattggt gcgggacacg
     4381 ctggggttga ggcttccttg gccgctagcc gtatgggctg taaggtcctg cttgcgacca
     4441 tcaatattga aatgctggct ttcatgcctt gtaatccctc tatcggtggt tctgccaagg
     4501 ggattgtcgt gcgtgaagtc gatgccctcg gtggcgagat ggccaaaacc attgacaaga
     4561 cttacatcca gatgaagatg ctaaacacag ggaaggggcc agctgtccgt gcccttcgtg
     4621 cgcaggctga caaggaactt tactctaagg agatgcgcaa gacggttgaa aaccaagaaa
     4681 atctgaccct tcgtcaaacc atgattgatg agattttggt ggaagatggc aaggttgtcg
     4741 gtgtgcgtac agccacccat caagaatatg ctgctaaggc tgttattgtg acgacaggga
     4801 ctgctctccg tggggaaatt atcatcggag acctcaagta ctcatcaggt cctaaccaca
     4861 gcttggcttc tattaaccta gctgacaatc tcaaggaact gggtctcgaa atcggtcgtt
     4921 tcaagacagg aacccctcca cgtgtcaagg cttcttctat caattacgat gtgacagaaa
     4981 ttcagccagg agacgaagtg cctaatcatt tctcatacac ttcacgtgat gaggattatg
     5041 tcaaggacca agtaccatgc tggttgacct ataccaatgg taccagtcat gagattatcc
     5101 aaaacaacct ccaccgtgcg cctatgttta caggtgtggt caagggagtg gggcctcgtt
     5161 actgtccgtc gattgaagac aagattgtgc gctttgcgga caaggaacgt caccaactct
     5221 tccttgagcc agaagggcgc aatactgagg aagtctatgt gcaaggactt tcaaccagtc
     5281 tgcctgagga tgtccagcgt gacttggtgc attccatcaa aggtttggaa aatgcagaga
     5341 tgatgcggac aggttatgct attgagtatg atatggtctt gcctcatcag ttgcgtgcga
     5401 ctttggaaac caagaaaatc tcaggtctct tcactgctgg tcagacaaat ggaacatcag
     5461 gttacgaaga ggcagcaggc caagggatta tcgcgggtat caatgcggct ctgaaaatcc
     5521 aaggcaagcc tgaattgatt ttgaagcgca gtgatggtta tatcggggtg atgatcgacg
     5581 acttggtgac caagggaacc attgaaccct accgtctctt gaccagtcgt gctgaatacc
     5641 gtctcattct tcgtcatgac aatgctgata tgcgcttgac tgagatggga cgcgagattg
     5701 gccttgtgga cgatgaacgc tgggctcgtt ttgaaatcaa gaaaaatcaa tttgataatg
     5761 agatgaagcg cctagacagt atcaaactca agccagtcaa ggaaaccaat gccaaggttg
     5821 aggagatggg cttcaaaccc ttgaccgatg cagtgacagc caaggaattc cttcgccgtc
     5881 cagaagtttc ttaccaagat gtggtggcct tcatcggacc agctgcagaa gacttggatg
     5941 acaagattat cgaattgatt gaaacagaaa tcaagtatga aggctatatt tccaaagcca
     6001 tggaccaggt tgccaagatg aaacgcatgg aagaaaaacg cattccggcc aatatcgact
     6061 gggatgacat tgattctatc gcaaccgaag cccgtcagaa gttcaaactc atcaatccag
     6121 aaaccatcgg ccaagccagc cgtatttcgg gagtaaaccc agcagatatt tctattttga
     6181 tggtgtatct ggaaggtaaa aatcgtagta tttctaaaac tcttcaaaaa tcaaaatgat
     6241 acgtcgtcgg cttcttacga atgagttcaa agcttggctt tgattcatct ccagcctccc
     6301 atagtttccc gaactatggg agctaactca agttatgctt tcgcttagcc ttctagtctg
     6361 atttcgattt ttattgatac tcttcgaaaa tctcttcaaa ccgcgtcaac gtcgccttgc
     6421 cgtaggtatg gctactgact tcgtcagttc tatctacaac ctcaaagcag tgctttgagc
     6481 aacctacggc tagcttccta gtttgctctt tgattttcat tgagtatgag ttttaatctc
     6541 aaaagaaagc atagagaaaa acagctccga ggacggggct gttttcttgc tttattcttc
     6601 atctggtgtg aggatcatcg ggatgatgat cggttcacgt tcggtatttt catagaggaa
     6661 ggggcgaata gcgttgacaa tggcaccatt gacagattgc acgctagcat ccttattttt
     6721 cagtgcgata cgaatggcat tgaagaggat acgctggctt tggcgaatca agtctccaga
     6781 ctctctcatg tagacaaagc ctcggctgag gatatctggg ccagacagaa tcatctgcga
     6841 tttgaagtca acagttgcga ctgctagaac gacaccgtct tcagatagat cgcgacgatc
     6901 tttgaggaca gctgcgccaa tttcaccgat acgatttcca tcgacataga tatcttgggc
     6961 gttgaaatga cctgcgatac gagctgagtc agcagtaagg gcaagcacat cgccattgct
     7021 catgataaag atattgtcct tctcaacacc agtatccact gctagtccag cgtggacttt
     7081 ttgcatgcgg tattcaccgt ggacaggcat gaagtatttt ggcttaatca agcggagcat
     7141 gagtttttgc tcttgctggc caccgtgtcc agatgtatgg atattgttca ctttaccgtg
     7201 gataacttcg acaccagctt cagaaatgat gttaatcagc ttgttgacgc tagtagtgtt
     7261 tccagggatg ggactagaag agaagataac ggtatcacct ggttgtaatt gtacttgacg
     7321 gtgggttccg ttggcgatac gagagagggc tgccataggc tcaccctgac tacctgtaca
     7381 gaggataaga acttctcctg caggataatc tttgatttca tttggctcga taaaggttcc
     7441 cttaggagct ttgatgtagc caagatcgat tccgttgaca atggcctttt ccatagaacg
     7501 accaaagacc gcaatcttgc gtccagtctt aacagcagct tctgttgcct gctggagacg
     7561 gaagatattt gaggcaaagg atgcaaagat gatacgtcct tcaatacctt ggataatctt
     7621 cataatggac tgaccaacga ctttttcaga gttggtaaag gttggtactt ccgcatttgt
     7681 cgagtcagac aggagacaga gcacgccttc ttcaccaagc gcagccatac gatgcaagtc
     7741 cgcaggttct ccaactggag taaagtcgaa cttaaagtca cccgtacaga cgattttccc
     7801 ttgaggagta tgaatgacaa tccccaaagg ctctggaata gagtgagtcg ttctaaagaa
     7861 agttgccttg agatttttaa aggtcaactc ggtgttgtgg ttgatttcgt aaagtttggc
     7921 gttgcgcaag aggccgtgtt cttcgagttt cccacggatc aaagccaagg caagcggtcc
     7981 agcgtagata gggacatttg cttgcttgag taggaacgga atcccaccaa tgtggtcctc
     8041 gtgtccgtgt gtgattaaaa cagccttgac gcggtcgata ttgtccacga tgtaagagta
     8101 gtcaggaatg acatagtcga taccaagcaa gtcatcttct gggaatttaa tcccagcatc
     8161 gacgatgata atctcgtctt ggtattcaat tccgtaagtg tttttcccga tttctcctag
     8221 accaccgatg gcaaaaacgc cgacttcttc aggtttaaga gtgtaggcca tattagaact
     8281 ccgtaatttc gaaggcgcca gtttcttttt cgtaatcgag caatttgtca gacaagagtt
     8341 cgatatactc gatattgtac tctgggcgat tttcttcgac aagttggcga gcagtgatac
     8401 ggccctcaag ttctgagctg gcatcgatgt ctaggtaaag cgtgcgtgtt gtttcacggc
     8461 gtgggctacg ttcttttgtt tcttgataaa aaactttgta aatcatatag ttcctttcta
     8521 tttacaggtc agcttattcc aaacttttag cagatatttg cttgatttca ttccattttg
     8581 tgtctagatt gaccttgatt cgttacaatt atttcaatta taccacaaaa tgaaaaatta
     8641 gtaaaagacg gaaacgagaa agttagggga cgatttcttt ggtaagcgtt tgcaagaata
     8701 aagaaaatgt attatgttga taacggaagt gaaatttatt gcttgtcata attccatata
     8761 gattttaagt caaggaggtt gccctatgta taacttattt gcttttgcta tcggagctcg
     8821 cttggtagct tttattgttt ttgttgcttg cgtttatgcg gggaatcttc tatttgccaa
     8881 actggaacga cgacaaacca agttcttgtg gaaaatgacc tttgtgactc tctactcgct
     8941 ttttctcctc ctcgtgacct atgtcgtttg gtttgtattt tactttgaat taaatgctta
     9001 gatgccctgc ttatgctggg gttttttgtt tggggatgta gagatagtag atttacgaca
     9061 cgaaaattcc accccatcta tcaagatgag gtggtctttg catttttcta acatgacatg
     9121 acaatggaat tttcaaagct tattattttt atgggagtca ttgttctgat caaaaataga
     9181 gttgaagcat aaaaataaaa caatacaaac agataaatcg aatggtaaag ggatggtagt
     9241 aatgttcaaa tcattgagaa tgctgagcaa actgtaagag atgaagacaa taaaatttat
     9301 ccttctaaaa atgtgtttct tatctagcat gacttaccaa actttttacg aaggtctttt
     9361 ccaatggtat aacctgccat aaataaagcg ataccaacac cgacaccaaa gccacccttg
     9421 atttcttgca attccttatt agaaatttca cgataattgt tcaaatcttt catcatatta
     9481 atctcctcct aaaaaataac cagctgccaa accagaacct ataagtgctg ttccacctgc
     9541 aatagccttc caagatactg ctactccaaa gataaccaag ggagcgagac cgccatcaat
     9601 atctgataat tcattttcag ataaggataa aaattgattg tcaagaatgt caaaatttgt
     9661 cattgaactt tcctcctttt ttcttgttca cttttatatt cggaaaagaa aaggaaaagt
     9721 gagcattttt ttaaattatt tttagttaag tgagggcact cttgtctggg ggcaaagaaa
     9781 attcccatgt gccagctttt gtagtataat agtaagcaga caaaaagata ggaatgtgtt
     9841 atgaaagtat tagcttttga tacgtccagc aaggctcttt ctctggctat tttagaggat
     9901 aagcaggttc ttgccgagac gacgattaat attaagaaaa atcacagtat tactcttatg
     9961 cctgccatcg attttttgat ggcaagtttg gattggacac ccaaggattt ggaccgaatc
    10021 gtggtagctg aagggccggg tagctataca ggcttgcgaa ttgcggtagc aactgctaag
    10081 accttagctt acaccctgaa cattgagtta gttgggatgt cgagtctctt ggctctggtg
    10141 ccccaccaac aagaaggttt gtttgtcccc ttgatggatg cgcgtcgcaa taatgtttat
    10201 gcaggatttt atgaaaatgc caaacctgtc atggcagaag cgcacctatc ttttgaagag
    10261 gtgctagaaa aagtcaaggg tactagtcag gtaacctttg tcggagaagt tggccccttt
    10321 gttgagcaga ttcaaaaaca cttgccaagg actgattaca aagaaacatt gcccaatgca
    10381 gctaatctag ctcttttggc ctgggacaag gaagcagact ccttgcatga ttttgtgccg
    10441 aattacctca aacgagtcga ggctgaggaa aactggctca agaaccatac cgagtctggc
    10501 gagtcttaca ttaaacgcct atgatagaaa tcaagcgaat tcaacaacag cctgacctag
    10561 ctcaagccat ctacgctgtt atggcagctg tttacctagt cagtccttgg actctggagc
    10621 aaatccaagc agatctgtcc caagaccaga cttggtatgc attggcttat gatggggcag
    10681 aagtgattgg atttctagct gtgcaggaga atctttttga agcagaagtc ctgcaaatcg
    10741 ctgtcaaagg agcttatcag ggtcagggaa ttgcgtcagc cttgtttgct caattgccga
    10801 cagacaagga aattttcctc gaagtcagac agtcaaatca acgagcgcaa gcattttaca
    10861 agaaagaaaa gatggcagtt atcgctgagc gaaaggccta ctaccatgac ccagtcgagg
    10921 acgccattat catgaagaga gaaatagatg aaggatagat atattttagc atttgagaca
    10981 tcctgtgatg agaccagtgt cgccgtcttg aaaaacgacg atgagctctt gtccaatgtc
    11041 attgctagtc aaattgagag tcacaaacgt tttggtggcg tagtgcccga agtagccagt
    11101 cgtcaccatg tcgaggtcat tacagcctgt atcgaggagg cattggcaga agcagggatt
    11161 accgaagagg acgtgacagc tgttgcggtt acctatggac cgggcttagt cggagccttg
    11221 ctagttggct tgtcagctgc caagaccttt gcttgggctc acggacttcc gctgatccct
    11281 gttaatcaca tggctgggca cctcatggcc gctcagagtg tggagccttt ggagtttcct
    11341 ttgttggcac tcttggtcag cggtggccac acagagttgg tctatgtttc ggaggcagga
    11401 gattataaga ttgttgggga gacacgagac gatgcagttg gggaggctta tgacaaggtc
    11461 ggccgtgtca tgggcttgac ctatcctgca ggtcgtgaga ttgacgagct ggctcatcag
    11521 gggcaggata tttatgattt cccccgtgcc atgattaagg aagataatct ggagttctcc
    11581 ttctcaggtt tgaaatctgc ctttatcaat ctttatcaca atgccgagca aaagggagaa
    11641 agcctgtcta cagaagattt gtgtgcttcc ttccaagcag cagttatgga cattctcatg
    11701 gcaaaaacca agaaggcttt ggagaaatat cctgttaaaa ccctggttgt ggcaggtggt
    11761 gtggcagcca ataaaggtct cagagaacgc ctagcagccg aaatcacaga tgtcaaggtt
    11821 atcatccccc ctctgcgact ctgcggagac aatgcaggta tgattgccta tgccagcgtc
    11881 agcgagtgga acaaagaaaa cttcgcaggc tgggacctca atgccaaacc aagtcttgcc
    11941 tttgatacca tggaataaag agtggctctt tgtcaagtgt agtgggtagg cgaaaagcta
    12001 caatctggag agtacgaaat tcgtactctc ttttttgatg ttcaaagtca tcaaaatccg
    12061 ttttttaaaa ttgttaaagt tccggaaacc aaaggctttg cgcttgataa tcttaatcaa
    12121 attattggtc gcttcaagtt tagcgttgga ataaggcagc ttaagtgcgt tgataatctt
    12181 atctctatcc cttaaaaaag tccaaaagac cgtttgaaaa agcggatgaa ccgttggcag
    12241 ttcttgctca atcaatccaa agaaatggtc ggcattcttc tcttgaaaat gaaagagcag
    12301 gagttgatag agttcgtagt gaacctgtaa tccctcagag taagaaagca gcttatctcg
    12361 tacttcccga tgggttaagt gcattcgaaa cgtgggctga tagaatcgtt tctgacagag
    12421 cttgaagcta tactggtgta gtaaatcagt ccagtggact gatttagccc gagcctagaa
    12481 acgaaaaagc gagggttcca aaagcgcttg agcgcccgat actccaagga ttttcggtca
    12541 aattggttca tgatttggat tcgtactcgg ttcatagctc ggctcagatg ttggacaatg
    12601 tggaagcggt caagaacaat cttcgccttt ggaaagagtt gcttagcgag ccgataataa
    12661 gggctgtaca tgtccatggt gatgacctcg accagctccc gaacctctct ctgatagcgt
    12721 tggaaatggt ttcgaatcac cgcatgagtt cgcccgtcta aaattgcgag gatggatttg
    12781 gactcaaaat cttgggcaat gaagctcatt ttgctctttt tgaagctata ctcatcccaa
    12841 ctcataactt ttggcaactt ggtccaatcg gtttcaaact taaattccct cagttttcgg
    12901 atgacggtgg aagttgagac cgccaatctg tgggcaatct cagtcataga ctgcttttca
    12961 aggaggagct gagcgatttt ttgtctcacc atgttggaaa tctggcaatt tttcttgaca
    13021 atggatgttt gagaaacgac caccttaagg caattcttgc actgaaagcg gcgctttttg
    13081 agatgcagta ccgtgggtaa accctgacag tcgagaagcg gaattttaga ggctttctgg
    13141 aagtcgtatt tgatcatctt cccttgacaa tgaggacaag gaggagcggg ggaatccaac
    13201 tttgcctgaa cgactagatg ggtttggtat ttcagaacag acaagatttt gatatttttg
    13261 tcttccaatc cgagcaaatc tgtggtattc ttaagttgtt ccatatgaac cctttctaat
    13321 gagttggtta gacgcttttc attataggtc atatggggct ttttttctac aagaaacgac
    13381 cctataattc ctggggtggg attacccact acagaaatta tagagccaaa gcattccaaa
    13441 gtcttgtctg actctggaat gttttctgtt cacagttgtt ttgtaactgc ctaataagta
    13501 accgcgctat aacgaggtat ctaccgagat tgtcaattct ccagtatact gttataaaaa
    13561 acaaaactgg aggatttttt tatgtccccc catcgtccca tcgactgttc cgtagctgcc
    13621 caataacgga gtatagtcgg ctgaaacaag aataggacaa aagtgcctca agaaaagcat
    13681 cgtaatttga caatattatt ctgagatgtt tttgatgtaa gcccatattt tctcaatggg
    13741 attatactcg ggtgaatagg taggaagtgg taacagtcta tgccctgctc cttacacatg
    13801 ttcattctgt gaaaccttgc atggtccata atgataaggg atggtgtatc taaagtaggt
    13861 agtaagaatt tttggaagca agcttcgaaa aagtcactcg tcatcgtatc tttataggtc
    13921 atcggagcca tagtatattg aaacaaaaaa gggcattagt acttctataa cagtatcgca
    13981 atctctggtg tgcgttgtct cgatcttaat tcaaataatt atatcttctt ccagagagac
    14041 taactgcctg ctcaaggctc gatcatattc gagataaaaa taggtctcaa cccctgtctc
    14101 ataaatataa ataggagtca ggtagcttaa gtgattcaat tctttaagga accgatttac
    14161 tttttctggg tcttgttcgc agtaggtacg gctctttttt agactatatc ccatagcctt
    14221 tagagcgtaa tgaatagttg ttggaggaca gttgaattca gcagctattt cagtcaaata
    14281 agcatcggga tgagtttcaa tatagatctt taatttatct ctatcaactt tttcaattaa
    14341 tagtggaagt tttcttaaag ttagtgtgtt gaaacgtttt tatacagtgc taaaatttga
    14401 agtgtagtgc agatgtattt gtaatagtat tatagcaatt ctttggagaa ggtcgagaca
    14461 agagaaaata ggtatctttg agatataagc atgatttact ataaaattat tgagttattc
    14521 ataaaaattt ctctatcaaa tatcataatg cgtcgtttaa ggagatggtt acaatgcaat
    14581 atagttgtgg aaaaataaat attaatatcc ctgatggata tggagacatt aaggatatag
    14641 tgttttcggc tcatattata gttaggtata ataatggaca ttgtggaggt atagatccgc
    14701 atataattgg actttgtaaa aagcagatca gaaggatgtc tctatatcct attttgataa
    14761 tcgtat
//
LOCUS       DAVHIZ010000044        14759 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.046, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000044 DAVHIZ010000000
VERSION     DAVHIZ010000044.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14759)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14759)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14759
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.046"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..163
                     /locus_tag="VVO18_001547"
     CDS             <1..163
                     /locus_tag="VVO18_001547"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5586670.1"
                     /translation="VSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEKL
                     YAYIAEATA"
     gene            201..503
                     /locus_tag="VVO18_001548"
     CDS             201..503
                     /locus_tag="VVO18_001548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000590570.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5586671.1"
                     /translation="MIKILAACGAGVNSSHQIKSALEEELSNRGYDVHCDAVMVKDVN
                     EDLMKGYDIFTPIAATDLGFEPGIPVIEAGPILFCIPAMSVPVFDNIRLPAKQNMV"
     gene            511..1314
                     /locus_tag="VVO18_001549"
                     /pseudo
     CDS             511..1314
                     /locus_tag="VVO18_001549"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
     gene            1351..1827
                     /locus_tag="VVO18_001550"
     CDS             1351..1827
                     /locus_tag="VVO18_001550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146193.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aldose epimerase"
                     /protein_id="HEU5586672.1"
                     /translation="MPYFIGGHPGFNCPLLDDGVYEDYYLESEKEETCSVPRPFPETG
                     MLDFQDRSPWLEGQKEIDLSYDLFSKDAVTLDELQSRTIALRSLKHDKGLKVHFAEFP
                     NLIIWSTLNKGPFITFEPWSGLSTFLEEGEHLEDKKNVCLLEANQVEELGFEIEVL"
     gene            1984..2409
                     /gene="lacA"
                     /locus_tag="VVO18_001551"
     CDS             1984..2409
                     /gene="lacA"
                     /locus_tag="VVO18_001551"
                     /EC_number="5.3.1.26"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398701.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacA"
                     /protein_id="HEU5586673.1"
                     /translation="MSIVIGADAAGLRLKEVVKDFLEKENFHLVDVTAEGQDFVDVTL
                     AVAAEVNKEEQNLGIVIDAYGAGPFIVATKIKGMVAAEVSDERSAYMTRSHNNSRMIT
                     MGAQLVGDELAKNIAKGFVNGKYDGGRHQIRVDMLNKMG"
     gene            2440..2955
                     /gene="lacB"
                     /locus_tag="VVO18_001552"
     CDS             2440..2955
                     /gene="lacB"
                     /locus_tag="VVO18_001552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002994294.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="HEU5586674.1"
                     /translation="MRIAIGCDHIVTDEKMAVSEFLKSKGYEVIDFGTYDHTRTHYPI
                     FGKKVGEAVTSGQADLGVCICGTGVGINNAVNKVPGVRSALVRDMTTALYAKEQLNAN
                     VIGFGGKITGELLMCDIIEAFIHAEYKPSEENKKLIAKIEHVETHNAQQTDANFFTEF
                     LEKWDRGEYHD"
     gene            2966..3895
                     /locus_tag="VVO18_001553"
     CDS             2966..3895
                     /locus_tag="VVO18_001553"
                     /EC_number="2.7.1.144"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000604270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="HEU5586675.1"
                     /translation="MILTVTMNPSIDISYPLDELKIDTVNRVVDVTKTAGGKGLNVTR
                     VLSEFGDSVLATGLVGGNLGEFLVEHIDNQVKKDFFSIQGETRNCIAILHGDNQTEVL
                     EKGPEVLEQEGQDFLEHFKKLLESVEVVAISGSLPAGLPVDYYASLVELANQAGKPVV
                     LDCSGAALQAVLESPHKPTVIKPNNEELSQLLGREVSEDLDELKEVLQEPLFAGIEWI
                     IVSLGANGTFAKHGDTFYKVDIPRIQVVNPVGSGDSTVAGISSGLLHKESDAELLIKA
                     NVLGMLNAQEKMTGHVNMANYQVLYDQLIVKEV"
     gene            3897..4877
                     /gene="lacD"
                     /locus_tag="VVO18_001554"
     CDS             3897..4877
                     /gene="lacD"
                     /locus_tag="VVO18_001554"
                     /EC_number="4.1.2.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001229146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="HEU5586676.1"
                     /translation="MALTEQKRARLEKLSDENGIISALAFDQRGALKRLMAQHQTEEP
                     TVAQMEELKVLVADELTKYASSMLLDPEYGLPATKALDEKAGLLLAYEKTGYDTTSTK
                     RLPDCLDVWSAKRIKEEGADAVKFLLYYDVDSSDELNQEKQAYIERIGSECVAEDIPF
                     FLEILAYDEKIADAGSVEYAKVKPHKVIGAMKVFSDPRFNIDVLKVEVPVNIKYVEGF
                     AEGEVVYTREEAAAFFKAQDEATNLPYIYLSAGVSAKLFQDTLVFAHESGANFNGVLC
                     GRATWAGSVEAYIKDGEAAAREWLRTTGFENIDELNKVLQTTATSWKERV"
     gene            5111..5947
                     /locus_tag="VVO18_001555"
     CDS             5111..5947
                     /locus_tag="VVO18_001555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285719.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEU5586677.1"
                     /translation="MYRILNPMNHNVSLVRNDKGEEVIVIGKGIAFGKKKGDLIAENQ
                     VEKIFRMKTEESRENFMALLKDVPLDFITVTYEIIDKLSKKYHYPIQEYLYVTLTDHI
                     YCSYQALTQGRYKDSNLPDISAKYPVAFQIANEAFEIYRQKLADHFPEDEIIRIAYHF
                     INAEGENEVELVESIDKRKEILRNVEEVLTDYAIQRTKKNNHFYDRFMIHLNYFLDYL
                     DRSRDDNQSLLDMEDHIKQSYPKAFEIGSKIYDVITQHTGLDLYKSERVYLVLHIQRL
                     LS"
     gene            5983..6300
                     /locus_tag="VVO18_001556"
     CDS             5983..6300
                     /locus_tag="VVO18_001556"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU5586678.1"
                     /translation="MNREEVTLLGFEIVAYAGDARSKLLEALKAAEAGDFEKADALVE
                     EAGSCIAEAHHAQTSLLTKEASGEDLAYSVTMMHGQDHLMTTILLKDLMHHLIELYKR
                     GVK"
     gene            6300..7991
                     /locus_tag="VVO18_001557"
     CDS             6300..7991
                     /locus_tag="VVO18_001557"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS transporter subunit EIIC"
                     /protein_id="HEU5586679.1"
                     /translation="MNKLIAFIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIF
                     ILIAFVPNSWGFKWSDEVVAFLMKPYSYSMGILALLVAGTTAKSLTDSVNRSMEKTNQ
                     INYMSTLLAAIVGLLMLAADPIESGLATGFLGTKGLLSAFLAAFVTVAIYKVCVKNNV
                     TIRMPDEVPPNISQVFKDVIPFTLSVVSLYALDLLARYFVGSSVAESIGKFFAPLFSA
                     ADGYLGITIIFGAFAFFWFVGIHGPSIVEPAIAAITYANAEVNLNLLQQGMHADKILT
                     SGTQMFIVTMGGTGATLVVPFMFMWLTKSKRNRAIGRASVVPTFFGVNEPILFGAPLV
                     LNPIFFIPFIFAPIANVWIFKFFIETLGMNSFTANLPWTTPAPLGLVLGTNFQVLSFI
                     LAALLIVVDVVIYYPFLKVYDEQILEEERSGKSNDELKEKVAANFNTAKADAILEKAG
                     VDAAQNTITEETNVLVLCAGGGTSGLLANALNKAAAEYNVPVKAAAGGYGAHREMLPE
                     FNLVILAPQVASNFEDMKAETDKLGIKLAKTEGAQYIKLTRDGKGALVFVQEQFD"
     gene            8206..9612
                     /gene="lacG"
                     /locus_tag="VVO18_001558"
     CDS             8206..9612
                     /gene="lacG"
                     /locus_tag="VVO18_001558"
                     /EC_number="3.2.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001864138.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="HEU5586680.1"
                     /translation="MTKTLPKDFIFGGATAAYQAEGATHTDGKGPVAWDKYLEDNYWY
                     TAEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPTGYGQVNAKGVEFYHNLFAE
                     CHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVDYAAFCFEEFPEVNYWTTFNE
                     IGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVSHARAVKLYKEKGYKGEIGVVHAL
                     PTKYPLDHENPADVRAAELEDIIHNKFILDATYLGRYSAETMEGVNHILSVNGGSLNL
                     REEDFTALEAAKDLNDFLGINYYMSDWMEAFDGETEIIHNGKGEKGSSKYQIKGIGRR
                     VAPDYVSRTDWDWIIYPQGLYDQIMRVKKDYPNYKKIYITENGLGYKDEFVDNTVYDD
                     GRIDYVKQHLEILSDAIADGANVKGYFIWSLIDVFSWSNGYEKRYGLFYVDFETQERY
                     PKKSAHWYKKVAETQIID"
     gene            9655..9912
                     /locus_tag="VVO18_001559"
     CDS             9655..9912
                     /locus_tag="VVO18_001559"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000471575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3884 family protein"
                     /protein_id="HEU5586681.1"
                     /translation="MFKDFIQSIYEKVYIINFEKYSQIPCLTSEELKSLGKWYVSTGK
                     EWICHSDDELEEFKNLFLNFINPEEWDTISSDSDFMPFQQS"
     gene            complement(10191..10952)
                     /locus_tag="VVO18_001560"
     CDS             complement(10191..10952)
                     /locus_tag="VVO18_001560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000917571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU5586682.1"
                     /translation="MLKQEKLTKILEIVNSKGTITVKQIMDEIAVSDMTARRYLQELA
                     DKDLLIRVHGGAEKLRTNSLLTNERSNIEKQALQTAEKQEIAHFAGSLVEERETIFIG
                     PGTTLEFFARELPIDNIRVVTNSLPVFLILSERKLTDLILIGGNYRDITGAFVGTLTL
                     QNLSNLQFSKAFVSCNGIQNGALATFSEEEGEAQRIALNNSNKKYLLADHSKFNKFDF
                     YTFYNISNLDTIVSDSKLSDSILFKLSKHIKVIKP"
     gene            complement(11134..12096)
                     /gene="nrdF"
                     /locus_tag="VVO18_001561"
     CDS             complement(11134..12096)
                     /gene="nrdF"
                     /locus_tag="VVO18_001561"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit beta"
                     /protein_id="HEU5586683.1"
                     /translation="METYYKAINWNAIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDW
                     RKLSNKEKDLVGKVFGGLTLLDTMQSETGVQALRADIRTPHEEAVFNNIQFMESVHAK
                     SYSSIFSTLNTKAEIEEIFEWTNTNPYLQKKAEIVNEIYLNGSPLEKKVASVFLETFL
                     FYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELPEEEQEKLK
                     EWMYDLLYTLYENEEGYTESLYDGVGWTEEVKTFLRYNANKALMNMGQDPLFPDSADD
                     VNPIVMNGISTGTSNHDFFSQVGNGYLLGEVEVMQDDDYNYGLD"
     gene            complement(12284..14443)
                     /gene="nrdE"
                     /locus_tag="VVO18_001562"
     CDS             complement(12284..14443)
                     /gene="nrdE"
                     /locus_tag="VVO18_001562"
                     /EC_number="1.17.4.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000523276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class 1b ribonucleoside-diphosphate reductase
                     subunit alpha"
                     /protein_id="HEU5586684.1"
                     /translation="MGLKHLEDVTYFRLNNEINRPVNGQIMLHKDKEALDAFFKENVV
                     PNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKDQNFQFKSFMAAYKF
                     YNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLN
                     AGRARRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGY
                     EGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVR
                     VKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDELVANPNI
                     RKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPVDGKIIMSNLCSEILQVQEPS
                     LINDAQEFLQMGTDVSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPT
                     IDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVEFTSIYFMLMNYWTLVESNNIAR
                     ERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELFKNVFIPGVADWAELRDKVQ
                     EDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETI
                     PYYTSAYDMDMRKVIDVYAAATEHVDQGLSLTLFMRSDIPKGLYEWKRENKQTTRDLS
                     ILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI"
     gene            complement(14524..14742)
                     /gene="nrdH"
                     /locus_tag="VVO18_001563"
     CDS             complement(14524..14742)
                     /gene="nrdH"
                     /locus_tag="VVO18_001563"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259243.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glutaredoxin-like protein NrdH"
                     /protein_id="HEU5586685.1"
                     /translation="MVTVYSKNNCVQCKMTKRFLDSNNVSYREINLDEQPEYVDQVKE
                     LGFSAAPVIQTPTEVFSGFQPGKLKQLA"
BASE COUNT         4572 a         2673 c         3026 g         4488 t
ORIGIN      
        1 agtatccttg ctcttcttta tcatcaataa ttcaagttca agtcaaacga acattcttgc
       61 tcagttgatg gacttcttca caggaaatgg tcatcttgaa gacctatcaa aaatttctga
      121 accagaaaaa ctttatgctt acattgctga agcaaccgct taatcttgtc tattaaaaaa
      181 taaaatcgga ggaaatccaa atgattaaaa ttcttgctgc ctgcggtgca ggtgttaact
      241 caagtcacca aattaaaagt gctctagaag aagaactttc aaaccgtggt tatgatgttc
      301 actgtgatgc agtcatggtg aaagatgtaa acgaagacct tatgaaaggt tacgatatct
      361 ttacaccaat cgctgcaaca gaccttggtt ttgaaccagg tatcccagtt atcgaagctg
      421 ggccaatctt attctgtatc ccagcaatga gcgttccagt atttgacaat attagacttc
      481 ctgcgaaaca aaatatggta tagtagttct atgaatgatg aagcaagtaa acaactaact
      541 gatgcacgat ttaagcgtct tgttggtgtt cagcgtacca cttttgaaga gatgttagct
      601 gtattaaaaa cagcttatca acttaaacac gcaaaaggtg gacgaaaacc taaattaagc
      661 ctagaagacc ttcttatggc cactcttcaa tagtgcgaga atatcgaact tatgaacaaa
      721 ttgcggctga ttttggtatt cacgaaagca actttatccg tcggagccaa tgggttgaag
      781 taactcttgt tcaaagtggt gttacggttt caagaactcc tctcagctct gaggacacgg
      841 taatgattga tacgacggaa gtacaaatca atcgccctaa aaaaagaatt agcgaatgat
      901 tctggtaaaa agaaatgcca cgctatgaag gctcaagcga ttgtcacaag tcaagggaga
      961 attgtttctt tggatatcac tgtgaactat tgtcatgata tgaagttgtt caaaatgagt
     1021 tgcagaaata tcggacaagc tggtaaaatc ttggctgaca gtggttatca agggctcatg
     1081 aagatatatc ctcaagtaca aactccacgt aaatccagca aactcaagtc gctaatagct
     1141 gaagataaag cctataacca tgcgctatct aaggagagaa gcaaggttga gaacatcttt
     1201 gccaaagtaa aaacgtttaa aatgttttca acaacctatc gaaatcatcg taaacgcttc
     1261 ggattacgaa tgaatttgag tgctggtatt atcaatcatg aactaggatt ctagttttgc
     1321 aggaagtcta ataaagaaac tagcaaggtc atgccttact ttattggtgg acatccagga
     1381 tttaattgtc ctctacttga tgatggagtc tatgaagatt attatctaga gtctgagaaa
     1441 gaagagactt gctctgttcc acgtcctttc ccagaaacag gtatgttgga tttccaagat
     1501 agaagtccat ggctagaggg acaaaaagaa atagatctta gttatgatct tttcagcaaa
     1561 gatgcagtga ctttggatga attgcaatct cgaacaattg cccttcgttc tcttaaacat
     1621 gataagggat tgaaagtgca ttttgcagaa tttccaaacc tcatcatctg gtcaactttg
     1681 aacaagggac ctttcattac ctttgaacca tggtctggct tgtcaacatt ccttgaagaa
     1741 ggagaacatt tagaagataa gaagaatgtt tgtctcttag aagccaatca ggttgaagaa
     1801 ttagggtttg agatagaagt tttataaaaa agtaaaaaat aaataacaaa aacaaacaca
     1861 aactattgac ttcttcaaac aatagtagta tattatgttt gtgaggacta attgactgtt
     1921 ttttaaagac agccaataca ctgctggaat ccagcataga aaaaataaaa aggagtatac
     1981 aatatgtcta ttgttatcgg tgcagatgct gcaggtttga gattgaaaga agttgtgaaa
     2041 gacttcttag aaaaagaaaa cttccacctt gtggatgtta cagctgaagg tcaagacttt
     2101 gttgatgtga ctctcgctgt tgctgcagaa gtaaacaaag aagaacaaaa ccttggtatc
     2161 gtgattgatg cttatggagc tggtccattt atagttgcaa ctaagatcaa aggaatggtt
     2221 gctgcagaag tatctgacga acgttcagct tatatgactc gtagccacaa caactcacgt
     2281 atgatcacta tgggggcaca acttgttggt gatgaattgg ctaaaaacat cgctaaagga
     2341 tttgttaatg gtaaatacga cggtggacgt catcaaatcc gggttgacat gttgaacaaa
     2401 atgggctaat tagattacag taagaaaggt aagttaaaaa tgagaattgc aattggatgc
     2461 gaccacatcg taacagatga aaaaatggcg gtttcagaat ttttgaaatc aaaaggatat
     2521 gaagtcattg actttggtac atatgaccat acacggactc actacccaat ctttggtaaa
     2581 aaagtagggg aagctgtaac tagcggccaa gctgatcttg gagtatgtat ctgtggtact
     2641 ggtgttggta tcaacaacgc tgtaaataaa gttccaggtg ttcgctctgc cttggttcgt
     2701 gatatgacaa cagcccttta tgctaaagaa caattgaacg ccaacgttat cggttttggt
     2761 ggtaagatta ctggtgaatt gctcatgtgc gatatcatcg aagctttcat ccatgctgaa
     2821 tacaaaccat ctgaagaaaa caaaaaattg attgcgaaaa ttgaacatgt tgaaacacac
     2881 aatgctcaac aaacagatgc aaacttcttc actgaattcc ttgaaaaatg ggatcgcgga
     2941 gaataccacg actaagaggt gacctatgat tttaacagtc acaatgaacc catccattga
     3001 tatttcctat cccttggatg agttgaagat tgatactgtc aatcgtgtgg tagatgtaac
     3061 caaaacggct ggtggtaaag ggctcaatgt tacacgcgta ctttcagaat ttggcgattc
     3121 tgttcttgct actggtttag taggtggcaa ccttggtgag tttttggttg aacatatcga
     3181 taatcaagta aagaaagatt tcttctcaat tcagggagaa actcgtaact gtatcgctat
     3241 tctccacgga gacaaccaaa cagaagttct tgaaaaaggt cctgaagtat tggaacagga
     3301 aggtcaagac tttttggaac atttcaaaaa actcttggag tcagttgaag tagtggccat
     3361 ctcaggtagt ctgccagctg gccttccagt tgattactat gcgagcttgg tagaacttgc
     3421 taatcaagct ggcaagcctg tagtcttgga ctgctcaggt gcagcacttc aggctgttct
     3481 tgaatcaccc cataaaccaa cagtcatcaa accaaataat gaagaattgt ctcagcttct
     3541 tggaagagaa gtttctgagg atttggatga attaaaagaa gtacttcaag aacctttgtt
     3601 tgcagggatt gaatggatta tcgtttcact tggtgccaac ggtacttttg ccaaacatgg
     3661 tgacactttc tacaaggtag atattcctag aattcaggtg gtaaatcctg ttggatctgg
     3721 agactctact gtggcaggaa tttcttcagg acttcttcac aaagaatcgg atgcagaatt
     3781 actcatcaag gcaaatgtcc ttggtatgct caatgctcaa gaaaaaatga ctggtcatgt
     3841 caacatggcc aactatcaag ttctatatga tcaattaata gtaaaagagg tataaaatgg
     3901 ctttaacaga acaaaaacgt gcacgcttag aaaaactttc tgatgaaaat ggtatcatct
     3961 cagctcttgc atttgaccaa cgtggtgctt tgaaacgcct catggctcaa caccaaacag
     4021 aagaaccaac tgtggctcaa atggaagaac tgaaagtctt ggtagcagat gaattgacta
     4081 aatacgcttc atcaatgctt cttgaccctg agtatggact tccagcaact aaagctcttg
     4141 atgaaaaagc tggtcttctc cttgcttatg aaaaaacagg ttatgacaca acaagtacaa
     4201 aacgcttgcc agactgcttg gatgtttggt ctgcaaaacg tattaaagaa gagggtgcag
     4261 atgcagttaa attcttgctt tactatgatg tagatagttc agacgaactc aaccaagaaa
     4321 aacaagctta tatcgagcgt atcggttctg agtgtgtggc tgaagatatc ccattcttcc
     4381 ttgaaatcct tgcttacgat gaaaaaattg cagacgcagg ttctgtagaa tatgcgaaag
     4441 taaaaccaca caaagttatc ggtgctatga aagtcttttc agacccacgc tttaacattg
     4501 atgtcttgaa agttgaagtt cctgttaaca ttaaatatgt tgaaggcttc gctgaaggtg
     4561 aagtggttta cacacgtgaa gaagcagcag ccttcttcaa agcgcaagat gaagcaacga
     4621 acttgccata catttacttg agtgctggtg tatcagctaa actcttccaa gatactcttg
     4681 tatttgctca tgaatcaggt gcaaacttta acggagttct ttgtggccgt gctacatggg
     4741 caggatcagt tgaagcttac atcaaagatg gtgaagcagc agctcgcgaa tggcttcgca
     4801 caactggatt tgaaaacatt gatgagctca ataaagttct tcaaacaaca gcgacttcat
     4861 ggaaagaacg tgtgtaagaa agtcctccta gtttaggaac atgaatctaa aaaaatttaa
     4921 aaaaagttgt atgtaaaggt ttacaaaata acttacttgt gctatactta aatcacaagt
     4981 taatacaagg tgagtgttac taagtaatat taggcatgat cacaggtgaa ttagaaatca
     5041 gctgattttc tagttcattt gtggtcattt tttgtactca tatactttta agatataaaa
     5101 ggaggttgac atgtatcgaa ttctaaatcc aatgaatcac aatgtctcgc ttgtcagaaa
     5161 tgataaggga gaagaggtga ttgtaattgg taaggggatt gcattcggaa agaagaaggg
     5221 ggatttgatt gctgaaaatc aggttgagaa aatctttcgg atgaagaccg aagagtccag
     5281 agaaaacttt atggctcttc tcaaagatgt tccgcttgat tttatcacag tgacctatga
     5341 aatcattgat aagctatcaa agaaatatca ttatccgatt caagagtatc tctatgtaac
     5401 cttgacagat catatttact gttcttatca agctctaact caaggaaggt acaaggatag
     5461 taatctgcca gatatttccg ctaagtatcc tgtcgctttt caaatcgcaa atgaagcttt
     5521 tgaaatttac cgtcagaagc tagcagatca ttttcctgag gacgaaatta ttcggattgc
     5581 ttatcatttc attaatgctg aaggtgaaaa tgaagtggaa cttgtggagt cgattgataa
     5641 gaggaaagaa attctcagga atgttgaaga agttttaacg gactatgcaa ttcaacgaac
     5701 taaaaagaat aaccatttct atgatcgctt tatgatccat ttgaattatt tcttggatta
     5761 tttagacaga tctagagatg ataaccaatc acttctggat atggaagatc atattaaaca
     5821 atcctatcca aaagccttcg agattggttc caagatctat gatgtgatta cgcaacatac
     5881 gggtcttgat ttgtataaaa gtgaacgagt ttatctagtt ctacatatcc aacgtttatt
     5941 gtcataaaaa tttatttaaa actatataag gagaattcta tcatgaatag agaagaagta
     6001 acattgttag gttttgaaat cgtagcctat gctggcgatg ctcgttcaaa actattggaa
     6061 gccttgaagg ctgctgaagc tggtgatttt gaaaaagcgg acgctctggt agaggaagct
     6121 ggtagctgta ttgcagaggc tcaccacgcg caaacaagtc tattgactaa ggaagcttca
     6181 ggtgaggact tggcttatag tgtaaccatg atgcatggcc aagaccactt aatgacaact
     6241 atcttgttaa aagatttgat gcatcattta attgaactct acaagagagg agttaaataa
     6301 tgaataaact aattgcattt atcgagaaag gaaagccttt ctttgaaaaa ctatctcgta
     6361 atatctatct tcgtgctatt cgtgatggtt tcattgcagg tatgcctgtt attctcttct
     6421 caagtatctt tatcttgatt gcctttgtac caaactcatg gggctttaaa tggtctgatg
     6481 aagttgtagc ctttctgatg aaaccttata gctattctat gggtattctg gctctcttgg
     6541 tagctggtac aacagctaag tcattgactg actcagtaaa ccggagcatg gaaaaaacca
     6601 atcaaatcaa ctatatgtca acattgttgg cagcaattgt tggtttgttg atgttggcag
     6661 ctgatcctat cgaaagtggt ctagctactg gattcttggg gacaaaaggt ttgctttcag
     6721 ccttccttgc tgcctttgtt actgtagcca tctataaggt ttgtgttaag aacaacgtca
     6781 ctattcgtat gcctgacgaa gttccaccaa atatctcaca agtctttaaa gatgtgattc
     6841 cattcactct atctgttgtt tctctttatg ctcttgactt attagcacgt tattttgttg
     6901 gttctagtgt ggcagaatca atcggtaaat tcttcgcacc actcttctca gcagcagacg
     6961 gataccttgg tattaccatt atctttggtg cctttgcctt cttctggttt gttgggattc
     7021 atggtccatc tatcgttgaa ccagctatcg cagctattac ctatgccaat gccgaagtca
     7081 acttgaacct tctccaacaa gggatgcatg cagacaagat tcttacttct ggtacacaaa
     7141 tgtttatcgt taccatgggt ggtacaggtg cgacattggt cgttccattt atgttcatgt
     7201 ggttgacaaa atcgaaacgt aaccgtgcaa tcggacgtgc ttcagtagtt cctaccttct
     7261 tcggtgtaaa tgaaccaatc ttgtttggtg cacctcttgt tttgaatcca atcttcttca
     7321 ttccatttat ctttgctcca attgcaaacg tatggatttt caaattcttt attgaaactc
     7381 ttggaatgaa ctcattcact gctaatctac catggacaac tccagctcca ctaggtctag
     7441 ttcttggaac taacttccaa gtgctatcat tcattcttgc tgcccttcta attgtggttg
     7501 acgtagttat ttattaccca ttccttaaag tctatgatga acaaattctt gaagaagaac
     7561 gttcaggtaa gtctaatgat gaattgaaag aaaaagttgc tgcaaacttc aacactgcaa
     7621 aagcggatgc tattcttgaa aaagcgggtg tcgatgcagc acaaaatacc atcactgaag
     7681 aaacaaatgt cctcgttctc tgtgctggtg gaggtacaag tggactcctt gcaaatgctt
     7741 tgaataaggc agcagcagaa tacaatgtcc ctgtgaaagc agcagcaggc ggctatggtg
     7801 ctcaccgtga aatgttacca gagtttaatc tagttatcct tgcccctcaa gttgcttcaa
     7861 actttgaaga tatgaaggca gaaacagata agctcggtat taaacttgct aagacagaag
     7921 gcgctcaata catcaaatta actcgtgatg gaaaaggtgc cctagtattc gtacaagagc
     7981 aattcgatta aggctaggaa ctgtgaaaca gtctcccatc gttacggaaa tcgctatggc
     8041 gaatttccta atcgccttat taattcgtcg gtaaaaagat atcgttttta cctcctcatg
     8101 tcacaattca gtgacttggt acaagaagtg agatggagaa gcatggctca ctgactcctc
     8161 tcctctcact tttactttat ttaaatcaag aaataggtga aaaaaatgac aaaaacactt
     8221 ccaaaagact ttattttcgg tggcgcaaca gctgcttatc aagcagaagg tgctacacat
     8281 actgatggta aaggaccagt agcgtgggat aaatatcttg aagataacta ctggtacact
     8341 gcagaaccag ccagtgattt ttacaatcga tatccagttg acctcaagct agcagaagag
     8401 tatggtgtca atggcattcg aatttctatt gcctggtcac gtattttccc gactggttat
     8461 ggtcaagtaa atgctaaagg tgttgagttt tatcataatc tatttgcgga gtgccacaaa
     8521 cgtcatgttg agccctttgt aactcttcat cactttgaca cgccagaagc tctccactca
     8581 aatggcgact tcttaaaccg tgaaaacatt gaacactttg tagactacgc ggctttctgt
     8641 tttgaagaat ttccagaagt aaactattgg acaaccttca atgaaattgg accaatcggt
     8701 gatggtcaat atttagttgg taaattccct ccaggaattc agtacgacct tgccaaagtc
     8761 ttccaatcgc accacaatat gatggtgtct catgcacgcg cggtaaaatt gtacaaagag
     8821 aaaggctata aaggggaaat tggtgttgtt cacgccctgc ctactaaata tcctctagat
     8881 catgaaaatc cagcagatgt tcgtgcagct gagttggaag atatcatcca caataaattc
     8941 atcttagacg caacttatct aggtcgctat tcagctgaaa ccatggaagg tgtcaaccat
     9001 atcttatcag tcaatggtgg tagtttgaat cttcgtgaag aagattttac agcattagaa
     9061 gctgcaaaag acttgaatga tttcctagga atcaactact atatgagtga ctggatggaa
     9121 gcctttgatg gagaaactga aattatccat aatggtaaag gtgaaaaagg aagctctaag
     9181 tatcaaatca aaggtattgg tcgtcgtgta gctcctgact atgtatcacg cacggattgg
     9241 gattggatta tctaccctca aggtttgtat gaccaaatca tgcgtgtgaa gaaagattat
     9301 cctaactaca agaaaattta tatcactgaa aatggtctcg gctataaaga tgagttcgtt
     9361 gataacactg tttacgatga tggtcgtatt gattacgtga aacaacactt ggagatcttg
     9421 tctgatgcga ttgcagatgg agctaatgta aaaggttact tcatttggtc attaatagat
     9481 gtcttctcat ggtcaaacgg ttatgagaaa cgttatggtc tcttctacgt agattttgaa
     9541 actcaagaac gttatcctaa gaaatcagct cactggtaca aaaaagtagc ggaaactcag
     9601 attatagact agtagaatta gtcattagat atagaatttt agtgagtcaa aaagatgttc
     9661 aaagatttta tccaatctat ttatgaaaaa gtttatatta taaatttcga aaaatactct
     9721 caaataccgt gtttgacgag tgaagaattg aaaagtcttg gaaaatggta tgtctcgact
     9781 ggtaaagaat ggatttgtca ttcagatgat gagctggaag aatttaaaaa tctattttta
     9841 aattttatca atcctgaaga atgggatact atctcctctg attcagattt tatgccgttt
     9901 caacaatcgt aaccaatttc tcaaaaaagt taaatcttat atttagtact ctgtaaaact
     9961 cttatctaat cacgttgctt atactcaatg aaaatcaaag agtaacttta aactaggaag
    10021 cgagtcgcag atttctcaat gtatagcttt gaggaattgg gcaaaaagtc tttgatatag
    10081 aaaaacgcat agtatcaggt gtttcaacac ctgatactat gcgttttatt gtgggaagat
    10141 gtactttttt tcttctgaaa ttgagttgtt acccaggctc tttcagttta ttaaggcttg
    10201 atgactttaa tgtgtttaga tagcttaaaa aggattgaat cacttagttt agaatctgaa
    10261 acaatagtat caagatttga tatattataa aaagtataaa aatcaaactt attgaactta
    10321 ctatgatctg cgagtaaata ttttttatta gaattattta aagcgatgcg ttgagcctct
    10381 ccctcttcct cgctaaaagt agctagagct ccgttttgaa taccattaca gctaacgaaa
    10441 gctttagaaa attggagatt agagagattt tgtagggtca atgtgccaac aaaagcacct
    10501 gtaatatcgc gataatttcc acctattaaa atcaaatctg ttaattttcg ttcgcttaaa
    10561 atcagaaaaa caggtagact gttggttacg acgcggatat tgtcaatagg caactcacgc
    10621 gcaaaaaact ctaatgttgt tcctggtcca atgaaaatag tttctctttc ttctactaga
    10681 ctgcctgcaa aatgggctat ttcttgtttt tctgccgttt ggagggcttg tttttcaata
    10741 tttgatcgct cattagtcaa aagggagttg gttcgaagtt tttcagctcc accatgcaca
    10801 cgaatcagca aatctttatc agctaattcc tgtaaatagc gccttgcagt catatctgaa
    10861 acggctattt cgtccataat ctgtttaacc gttatggttc ctttgctatt tactatctct
    10921 aaaattttgg ttaatttttc ttgtttgagc atattatcac ctcgtttcct actactatct
    10981 taccataaac aaactcatca ttcaaataca aaaacaacaa aatgaaacaa aaacaaaaat
    11041 atcgaagttt gttttcaaaa ctttcgatat ttttgttggg ttataacttt gatgtttcta
    11101 gtttactttt tgatgattga gagtggtgga gaattagtct aaaccgtagt tatagtcatc
    11161 gtcttgcatg acttcaactt cgccaagaag gtaaccattt ccgacttgag agaagaagtc
    11221 gtggttggaa gttcctgttg aaataccgtt cattacgatt gggttgacat catcagctga
    11281 atctgggaag agtggatctt gtcccatgtt catgagagct ttattggcat tgtagcgaag
    11341 gaaggtttta acctcttcag tccaaccaac accgtcataa agactctctg tgtagccttc
    11401 ttcattttca taaagagtat agagtaggtc gtacatccat tctttgagtt tttcttgctc
    11461 ttcttcaggt aattcattga aaccaagttg gaatttgtaa ccaatgtagg ttccgtgaac
    11521 agactcgtca cgaataatca atttaatgat ttctgcaacg ttggcaagtt tgttgttacc
    11581 gagatagtag aggggagtga agaaaccaga gtagaagagg aaggtttcga ggaagacgct
    11641 ggcaactttc ttttcaagtg ggctgccgtt taggtagatt tcgttgacaa tctcagcctt
    11701 cttttgtagg taaggattgg tattggtcca ttcgaaaatt tcttcaatct cagccttagt
    11761 attcaaggta gaaaagattg atgagtaaga tttagcgtgg acagattcca taaattggat
    11821 gttattgaaa acagcttcct catgtggtgt acggatgtct gcgcgaaggg cttgaacccc
    11881 agtttcagat tgcatagtgt caagaagggt taaaccacca aaaacttttc cgaccaagtc
    11941 tttctctttg ttagatagct ttctccagtc atccaagtcg tttgataagg gaatacgtgt
    12001 atcgagccaa aattgctccg tcagtttttc ccaagttgat ttgtcgatga catcttcgat
    12061 ggcattccag ttaatggctt tgtagtaagt ttccatttaa aatctctttc tgtgtttagt
    12121 attgcgaact cacaattatt tctactttac cataattcta taggagtatc gcacaaaaag
    12181 tcggaagccc gacttttaaa atgttacata aattatgtta tgacatagta gatttgattt
    12241 tatcagtgct gcttagggaa aaatagtgtt tctatgctag aaactaaatc acacagcttt
    12301 cacattggtt ggcgccgact tctccaccgt catctgtaaa ggtacggacg tagtagatag
    12361 acttgattcc cttgttaaag gcatagttac gaaggatgga caagtcacgt gtcgtttgtt
    12421 tattttccct cttccattcg taaaggcctt ttggaatgtc actgcgcatg aagagggtga
    12481 gtgaaagtcc ttgatccacg tgttcagtcg cagcagcgta aacatcgatg actttacgca
    12541 tatccatatc gtaggcagaa gtgtagtaag gaatggtttc tgtagacaag ccagcagcag
    12601 ggtagtagat tttaccaatt ttcttctctt ggcgttcttc gatacgttgc gtaatcgggt
    12661 ggatagaagc agaaacgtcg ttgatatagc tgatagaacc atttggcgct acagcaaggc
    12721 gattttggtg gtaaagacca tcttcttgaa ccttgtcgcg aagttcagcc caatcagcaa
    12781 caccagggat aaaaacattt ttgaagagtt ctttaacacg gtctgatgtt ggaacaaatt
    12841 caccagttac atacttgtca aagtaacttc cgttagcata gtctgatttt tcaaagttgt
    12901 ggaaggtaat accacgttca cgcgcaatat tgtttgactc taccaaggtc cagtagttca
    12961 taagcataaa gtagatgctt gtaaattcaa cagactcagg tgaaccatat tcaatgagtt
    13021 gttgggcaag gtagctgtgc agtcccatgg caccgagacc aaaggtgtgg gcttggctat
    13081 ttccatggtc aatcgttggt acagctacga tatgtgaact atctgtaacg aaagtaaggg
    13141 cacgaaccat agcacggata gaacgaccaa aatcaggtga agtcatcatg ttaaccacgt
    13201 tggttgaacc cagattacat gaaacatctg ttcccatttg aaggaattct tgagcatcgt
    13261 tgatcaagct tggttcttga acttgaagaa tctcagaaca caagttactc atgataatct
    13321 ttccatcaac aggatttgca cggttagctg tatcgatgtt gactacataa ggatagccag
    13381 actcttgttg caatttagag atttcagttt ccaaatcccg cgccttgatt tttgtcttgc
    13441 gaatatttgg atttgcgacc aattcatcgt atttttcagt aatgtcgatg taattgaatg
    13501 gcacaccgta ttctttttct acagagtaag ggctgaagag gtacatttct tcatttttac
    13561 gagccaattc gtagaattta tcaggtacta caacaccaag tgatagagtc ttgacacgta
    13621 ctttttcatc agcgttttct ttcttagttg aaaggaaagc gatgatatct gggtgaaaga
    13681 cgttgaggta gacaacaccg gcaccttgac gttgccccaa ttggttggag taagagaagc
    13741 tgtcttcaaa aagcttcata acaggaacga cacctgaagc agctccttca tagcctttga
    13801 taggtgcacc agcttcacga aggttgctga gggtaattcc cacaccacca ccaatacgtg
    13861 aaagttgaag agctgagttg atagaacgtc cgatagagtt catatcatcc gtcacttgga
    13921 ttaggaaaca agataccaac tccccacgac gagcacgtcc agcattcaag aaggaaggag
    13981 tagcaggttg gtagcgttgg tggatgattt cattggcaat atcgattgca acagcttcat
    14041 tcccatcagc gaaataaagg gcgttgaaga agacacggtc ttccatattt tcaagatagt
    14101 attcaccgtc attagtcttt aaggcatatt gattgtaaaa tttataagct gccatgaatg
    14161 acttgaattg gaagttttgg tctttgataa attgagccaa ttcttccaag aactctggac
    14221 ggtatttctt gataaaggct gtttcgatgt agttgtgttc aatgaggtaa ttgattttgt
    14281 ctttgattga atcaaaaacc atagtgtttg gaactacatt ttctttaaag aaagcatcca
    14341 aggcttcctt gtctttatga agcatgattt gtccattaac aggacggtta atttcgttat
    14401 taagacggaa gtaagtcacg tcttcaagat gttttaatcc cataaaattt cccttatcta
    14461 attacaaaag aaaggcttct aagttagccc taaaagcagt ttcttctgga tgatgtacta
    14521 agattatgct aattgtttca gttttcctgg ttggaaacct gaaaagactt cagttggtgt
    14581 ttggataaca ggagctgcgc taaaaccgag ctctttaact tgatcgacgt actcaggttg
    14641 ctcatcaaga ttgatttcac gataagagac attattactg tccaagaaac gcttggtcat
    14701 tttacattgg acacaattgt ttttagaata aacggttacc attgtgtaac tcctcttca
//
LOCUS       DAVHIZ010000045        14386 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.047, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000045 DAVHIZ010000000
VERSION     DAVHIZ010000045.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14386)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14386)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14386
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.047"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1400
                     /locus_tag="VVO18_001564"
     CDS             <1..1400
                     /locus_tag="VVO18_001564"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205273.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5586686.1"
                     /translation="SELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRIINTDD
                     SDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVIKR
                     QFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFENFSSEPLSQLLELVYKET
                     SFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFE
                     SEYNISLDEEVVCQLFVSYFQKMFFIDESLFMKYVKKDSYVEKSYHLLSDFIDQISVK
                     YQIEMENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDIKKEL
                     SHYLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVA
                     ETLSYYCSNNFELEVWTELELSKESLEDSPYDIIISNFIIPPIENKRLIYSNNINTVS
                     LIYLLNAMMFIRLDE"
     gene            1762..2763
                     /locus_tag="VVO18_001565"
     CDS             1762..2763
                     /locus_tag="VVO18_001565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000230206.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5586687.1"
                     /translation="MVEQRKSITMKDVALEAGVSVGTVSRVINKEKGIKEVTLKKVEQ
                     AIKTLNYIPDYYARGMKKNRTETIAIIVPSIWHPFFSEFAMHVENEVYKRNNKLLLCS
                     INGTNREQDYLEMLRHNKVDGVVAITYSPIEHYLTSGIPFVSIDRTYSDIAIPCVSSD
                     NDAGGREAAKQLISKGCQHLAFVGGHNTTINETKRRRISFEKYVQEHKIPLSIFDLDE
                     TVTDYYGKLESFLEENSSIDGIFTINDFTALDVIEILKKNGKRIPHDVQIIGYDGIKM
                     AGDRDYLLSTIEQPLEEMAKEAVRILFDIIDGKTVNLQTILPVKFVEGKTTKNENKS"
     gene            2913..3830
                     /locus_tag="VVO18_001566"
     CDS             2913..3830
                     /locus_tag="VVO18_001566"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084977.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5586688.1"
                     /translation="MNSKAKQVSLWERIKKQKLLLLMTVPGLVLTFIFKYIPMYGVLI
                     AFKDYNPLKGILGSDWIGFSEFTKFISSPNFGILLANTLKLSIYGLLLGFLPPIILAI
                     MLNQLLSEKVKKRIQLILYAPNFISVVVIVGMIFLFFSVGGPINNFLSMFGMKADFLT
                     NPDFFRPLYIFSGIWQGMGWASTLYTATLVNVDPALVEAARLDGANIFQRIWHIDIPA
                     LKPIMVIQFVLAAGGIMNVGYEKAFLMQTSLNLPTSEIISTYVYKVGLVSGDYSYSTA
                     VGLFNAVINVVLLVAVNQIVKRMNNGEGI"
     gene            3841..4731
                     /locus_tag="VVO18_001567"
     CDS             3841..4731
                     /locus_tag="VVO18_001567"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797960.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU5586689.1"
                     /translation="MKNSIMDTKFDRRILLLNKIIIVFIVLMTLLPLLYIVVASFMDP
                     KVLVSRGISFNPADWTVEGYQRVFSDQSILRGFINSLLYSFGFAALTVLLSVFTAYPL
                     SKKDLVGRRWINYFLIVTMFFGGGLVPTYLLVKELGMLNTPWAIIVPGAVNVWNIILA
                     RAYFQGLPEELVEAAVIDGANDLQIFFKIMLPLAKPIMFVLFLYAFVGQWNSYFDAMI
                     YIKDPNLEPLQLVLRKILIQSQPGQDMIGAQAAMNEMKRLAELIKYATIVISSLPLIV
                     MYPFFQKYFDKGIMAGSLKG"
     gene            4760..6376
                     /locus_tag="VVO18_001568"
     CDS             4760..6376
                     /locus_tag="VVO18_001568"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669747.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5586690.1"
                     /translation="MKFKTFSKSAVLLTASLAVLAACGSKNTASSPDYKLEGVTFPLQ
                     EKKTLKFMTASSPLSPKDPNEKLILQRLEKETGVHIDWTNYQSDFAEKRNLDISSGDL
                     PDAIHNDGASDVDLMNWAKKGVIIPVEDLIDKYMPNLKKILDEKPEYKALMTAPDGHI
                     YSFPWIEELGDGKESIHSVNDMAWINKDWLKKLGLEMPKTTDDLIKVLEAFKNGDPNG
                     NGEADEIPFTFISGNGNEDFKFLFAAFDIGDNDDHLVVGNDGKVDFTADNDNYKEGVK
                     FIRQLQEKGLIDKEAFEHDWNSYIAKGHDQKFGVYFTWDKNNVTGSNESYDVLPVLAG
                     PSGQKHVARTNGMGFARDKMVITSVNKNLELTAKWIDAQYAPLQSVQNNWGTYGDDKQ
                     QNIFELDQASNSLKHLPLNGTAPAELRQKTEVGGPLAILDSYYGKVTTMPDDAKWRLD
                     LIKEYYVPYMSNDNNYPRVFMTQEDLDKIAHIEADMNDYIYRKRAEWIVNGNIDTEWD
                     DYKKELEKYGLSDYLAIKQKYYDQYQANKN"
     gene            6386..7705
                     /locus_tag="VVO18_001569"
     CDS             6386..7705
                     /locus_tag="VVO18_001569"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866559.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 32 protein"
                     /protein_id="HEU5586691.1"
                     /translation="MGDKKYTVEKANRFIAENKHLVNTQYKPEEHFSAEIGWINDPNG
                     FVYFRGEYHLFYQFYPYDSVWGPMHWGHAKSKDLVTWEHLPVALAPDQDYDRNGCFSG
                     SAIVKDDRLWLMYTGHIEEKTGVRQVQNMAFSDDGIHFEKISQNPVVTGTDLPDELIA
                     ADFRDPKLFEKDGRYYSVVAVKHMDNVGCIVLLGSDNLVEWQFESIFLKGGEHQGFMW
                     ECPDYFELDGKDCLIMSPMRYQREGDSYHNINSSLLFTGKVDWREKRFIPESVQEIDH
                     GQDFYAPQTLLDDQNRRILIAWMQTWGRTLPTHDQEHKWACAMTLPRILRLEDGKLRQ
                     FPVKKGQYQIQIDKDCHYHLGNDIDYLEFGYDSNAQQVYIDRSHLIQKILGEEEQDTS
                     RRYVDIEAKELEVVLDKNSIEIFVNQGEASLTATYYLTVPAELSRID"
     gene            complement(7915..7987)
                     /locus_tag="VVO18_001570"
     tRNA            complement(7915..7987)
                     /locus_tag="VVO18_001570"
                     /product="tRNA-Lys"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(7952..7954),aa:Lys,seq:ctt)
     gene            complement(8252..9523)
                     /locus_tag="VVO18_001571"
     CDS             complement(8252..9523)
                     /locus_tag="VVO18_001571"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001113185.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated recombination protein A"
                     /protein_id="HEU5586692.1"
                     /translation="MPDNLALRMRPKTIDQVIGQEHLVGPGKIIRRMVEANRLSSMIL
                     YGPPGIGKTSIASAIAGTTKYAFRTFNATVDSKKRLQEISEEAKFSGGLVLLLDEIHR
                     LDKTKQDFLLPLLESGLVIMIGATTENPFFSVTPAIRSRVQIFELEPLSNQDVKEALQ
                     IALSNPERGFDFPIELDEDALDFIATSTNGDLRSAFNSLDLAVLSTPENDEGIRHITL
                     DIMENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVDASLHYAARLIEAGDLPSLAR
                     RLTVIAYEDIGLANPEAQIHTVTALDAAQKIGFPEARILIANVVIDLALSPKSNSAYV
                     AMDKALTDLKTSGHLPIPRHLRDGHYSGSKELGNAQDYLYPHNYPGNWVKQDYLPEKI
                     RNHHYFQAEDTGKYERALAQRKEAIDRLRKI"
     gene            9793..10032
                     /locus_tag="VVO18_001572"
     CDS             9793..10032
                     /locus_tag="VVO18_001572"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000818079.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586693.1"
                     /translation="MKREVISNGNDGPSQEILIFTKQIRHWILSDQVISGKRKLFFRE
                     DTPKEILDLYENIKSKLDFAYQEVYSNNGLKKYEK"
     gene            10197..10376
                     /locus_tag="VVO18_001573"
     CDS             10197..10376
                     /locus_tag="VVO18_001573"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586694.1"
                     /translation="MNLIFEEYQFVKIGDKKYRVRSVPMIHSTPPQSVLDRDTFTIDY
                     TDDELLDKEAVFTTH"
     gene            10513..10692
                     /locus_tag="VVO18_001574"
     CDS             10513..10692
                     /locus_tag="VVO18_001574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family
                     toxin"
                     /protein_id="HEU5586695.1"
                     /translation="MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGE
                     LNKYTERGIRKQAGL"
     gene            10729..11181
                     /locus_tag="VVO18_001575"
     CDS             10729..11181
                     /locus_tag="VVO18_001575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000961815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="HEU5586696.1"
                     /translation="MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAM
                     GSEWLGITVADLIESDGELPQPSDINSLSLIDNDPFKDDEDFVSTYDLDKSFISMVSV
                     DVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA"
     gene            11472..11942
                     /locus_tag="VVO18_001576"
     CDS             11472..11942
                     /locus_tag="VVO18_001576"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000257105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3013 family protein"
                     /protein_id="HEU5586697.1"
                     /translation="MATYGFLDVLEEELDKNFPFDFEISWDKRNYAVEVSFLLEAQNA
                     AGVEMVDEDGEVSSDDILFEEAVLFYNPAKSTVNEEDYLTVIPYLPKKGFSREFLAYF
                     ALFLKDTAEVGLDALMDFLEDPEAEEFVMEWNQEVFEEGKVGLEEGEFYPYPKY"
     gene            11961..13049
                     /locus_tag="VVO18_001577"
     CDS             11961..13049
                     /locus_tag="VVO18_001577"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719715.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="site-2 protease family protein"
                     /protein_id="HEU5586698.1"
                     /translation="MKKIGTYLVYVLAVVFIMLAFACGTIAFAELGYSAVLAFTFGYA
                     FALLSMYLIFILHELGHAFCGYLTGYRLVAFGLGHFILTKKSGRFHLSRTAILKNVGA
                     QYIGLKEDESDQRIILMLSGGLMVHLGLILLAILFGFLTRSWYFAGTWIFLNLSFFLN
                     NILPVDITDGAKIWELLQHPENTKYAYLVLRHSAQTLLAPQEYDLKDFVQAVPEDARG
                     SFADGVLGMQGEVSILEGKEEVAKQQFQALLERTTTPMMQTVAQLSLLHIALLEGDFE
                     QAEQYASIRQVKSFLSLKLSNLQVIQAWYQFKVRKDVVQTHKAMKIARQKMDSSRMLR
                     DEKRYYENLLAELEKEMLEGTEDGTRNF"
     gene            13030..13188
                     /locus_tag="VVO18_001578"
     CDS             13030..13188
                     /locus_tag="VVO18_001578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="7,8-dihydro-8-oxoguanine-triphosphatase"
                     /protein_id="HEU5586699.1"
                     /translation="MELEISDFPGCKIALFCGDKLLTILRDDKASIPWANMWELPGGG
                     KSVRENLI"
     gene            13298..14332
                     /locus_tag="VVO18_001579"
     CDS             13298..14332
                     /locus_tag="VVO18_001579"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863657.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEU5586700.1"
                     /translation="MKKSDVLDLIKYHYEGRETEFRNQSIAIARNFNKHGDTQIAQYI
                     MGLMSQSDRFMPQIENPSEYLTPAKLDIGPLPLPLSIMNDLKGIINAVNHHIGINKFL
                     FVGSPGTGKTESVKQVARLIGKELLVVDFSHLVDSKLGQTVKNLATLFNEINNLPFKQ
                     NYIILFDEIDSIVLDRVNQNDLREMGRVTSAFLKELDRLSPEIVLIATTNLFENLDKA
                     VTRRFDAIIDFDRYTDEDKVEVATIILNELLKQFKNVARDLKLFKKIINSANVIPNPG
                     DLRNSIRTSLAFSDPSDPHDYQKRLLRSLHNGRNLSISKLSKLGFTVREIEILTGVSK
                     SSVSRELSED"
BASE COUNT         4652 a         2326 c         2963 g         4445 t
ORIGIN      
        1 gttctgaact agcagagtta ttaaattgta cagaacgtgc agtcaaagat gatctatccc
       61 atgttaaatc tgcttttcct gacttgattt ttcattcttc tactaatggt atacgcatta
      121 ttaataccga tgatagtgat attgaaatgg tttaccatca tttctttaaa cattcaactc
      181 atttttcgat tttagaattc atcttcttta atgaaggttg tcaagctgag agtatttgta
      241 aagaatttta tatcagttca tcttcgctct atcgtattat tagccaaatc aataaagtga
      301 ttaaaaggca atttcaattt gaagtcagtc tgacccctgt tcaaatcatt ggaaatgaga
      361 gagacattcg ttactttttt gcacaatatt tttcagaaaa atattatttc ctagaatggc
      421 catttgaaaa tttttcatca gagccactat ctcaattgtt agaattggtt tataaggaaa
      481 caagctttcc aatgaattta tcaacgcata gaatgctaaa gttgctccta gttacgaacc
      541 tatatagaat aaagtttggt cattttatgg aagtagataa agattctttt aacgaccaaa
      601 gtttggattt tttaatgcag gcagaaggaa tagaaggtgt tgctcagagt tttgaatcag
      661 aatacaatat ctctttagat gaagaagttg tttgccaatt atttgtgtct tactttcaaa
      721 aaatgttttt catagatgaa agtctcttta tgaaatacgt aaaaaaggat agttatgttg
      781 aaaaatctta ccatctattg agtgatttta ttgatcagat ttcagtcaag tatcagattg
      841 aaatggagaa taaggataat ctgatttggc atctgcataa taccgcacat ctgtatcgtc
      901 aagagttgtt cactgagttt attttatttg atcaaaaagg gaatacaatc aggaactttc
      961 aaaatatttt tccaaaattt gtttcagata taaaaaaaga gctttctcac tatttagaga
     1021 ctcttgaggt ttgttctagt tcaatgatgg taaatcatct atcttatacc ttcatcactc
     1081 ataccaaaca tttggtgatt aatttgctac aaaatcagcc taaactaaag gttttagtta
     1141 tgagtaattt tgatcagtat catgcaaaat tcgttgcaga gacactttct tattactgta
     1201 gcaataattt tgaactggag gtttggaccg aattagaatt atcaaaggaa tctttagaag
     1261 attcacctta tgatatcatt atttccaatt ttattattcc tcctattgaa aataagagac
     1321 tcatctattc aaataatata aacacggtct cactcatata tttgttaaat gccatgatgt
     1381 ttattcgatt agatgagtaa ccaaaaataa caaaaaaacg ctatttcgcg tttgaactgt
     1441 acctcaaaag ttagacagaa aaagtctaat ttttggggtg tttttgttaa gaaaagacct
     1501 tcaatcattt aagaaaaatg tacatctaga tttatagcca tctaaaactc ttgctttttt
     1561 tgtagaagat acgaaaaaag ccatgaaacc aaggcttttc ctgttttatg tagatgttta
     1621 cacatgaaaa ttgaagtatt ttcaaaagct aattggagtg attttattca tgatgggata
     1681 aatgatctgg ccaaaaatga ttgagaaata gttgcttaaa aagcatttgc atgatactat
     1741 atattgaaag gaggtgataa tatggtagaa caaagaaaat caattaccat gaaagatgtt
     1801 gctttagaag caggagttag tgttggaact gtttcacgtg taattaataa agaaaaaggc
     1861 attaaagaag taactttgaa aaaagtggaa caagcgatta aaactttgaa ttacattcca
     1921 gattactacg ctagaggaat gaaaaaaaat cgaacagaaa cgattgcaat cattgtacca
     1981 agtatctggc atcccttctt ttcagaattt gctatgcatg tggaaaatga agtctataag
     2041 agaaataaca aattactctt atgttctatc aatggtacaa atagagagca agactatctg
     2101 gagatgttgc gtcataataa agttgatgga gtggttgcca ttacctatag tccaattgaa
     2161 cattacttga cgtcaggaat tccctttgtt agtattgacc gcacatactc agatattgcc
     2221 attccttgtg tttcatcaga taatgatgca ggtggaagag aagcagctaa acaattaatt
     2281 agtaaaggat gtcagcattt agcctttgtg ggcggacata atacaaccat taatgaaacc
     2341 aaacgtcgta gaatttcatt tgaaaagtat gtccaagagc ataaaatacc tcttagtatt
     2401 tttgatttgg atgagacagt tactgactat tatggaaagc tagagagttt cttggaagaa
     2461 aattcttcta tagatggaat ttttacaatc aacgatttta cagctttgga tgtgattgaa
     2521 atactaaaaa aaaatggcaa acgtattcct catgatgtcc aaattattgg atacgatgga
     2581 attaaaatgg ctggagatag agattatcta ctttcaacta ttgaacaacc attggaagaa
     2641 atggcaaaag aagcggttcg tattttgttt gatataattg atggaaagac tgttaatttg
     2701 cagacaatcc taccagtaaa atttgttgaa ggaaaaacaa caaaaaatga aaataagtct
     2761 tgacagaaag cgctatcaat gatagaatga attcagataa aaagatttat ttttaaaaca
     2821 aaaatgaaac gtttcaaaaa aagaaataaa gagacagcgc caagcgctat cttttctaga
     2881 acaaaaatga aacgtttcaa aaggaggttg ctatgaatag caaagcgaag caagtttctc
     2941 tttgggaaag aatcaagaaa caaaaactct tgttattgat gactgtccct ggtttagttt
     3001 taacctttat ctttaaatac atccctatgt atggggtttt aatcgcattt aaagattaca
     3061 atcccttaaa aggaatttta gggagtgatt ggattggttt ttctgagttt acaaaattca
     3121 tatcctctcc caactttggt atcttgttag ccaacacatt aaaattaagt atctatggtt
     3181 tattgcttgg ctttttacca ccaatcattc ttgctattat gctcaatcaa ctcttgagtg
     3241 aaaaagtcaa aaaacgaatt cagctcattt tatacgcacc aaactttatc tcagtcgttg
     3301 ttattgtcgg tatgattttc ctcttctttt cagtgggagg accaatcaac aattttcttt
     3361 ctatgtttgg aatgaaggct gacttcttga caaatccaga cttctttaga cctttataca
     3421 tctttagtgg tatctggcaa ggaatgggct gggcttcaac gctctacacg gcaacattgg
     3481 taaatgtaga tccagcctta gtagaagcag ctcgactgga tggagccaat atcttccaac
     3541 gaatctggca cattgatatt ccagctctta agcctattat ggttatccaa tttgttttag
     3601 ctgcaggtgg aattatgaat gtcggatatg aaaaagcatt cttgatgcag acatcgttaa
     3661 atttgccaac ttctgaaatt atctcgacat atgtctataa agttggtctt gtatcaggag
     3721 actattctta ctcaacagcg gttggtttgt ttaatgcagt gattaacgta gtattgcttg
     3781 ttgcagttaa ccaaatcgtt aaacgcatga ataatggtga aggaatttaa ggaggaaagt
     3841 atgaaaaatt cgattatgga tacaaaattt gatagacgta tcttactctt aaataaaatc
     3901 attattgtct ttatcgtttt gatgactttg cttcctttac tttatatcgt cgtagcatcc
     3961 tttatggatc ctaaggttct ggttagtaga gggattagct ttaatccagc cgattggact
     4021 gtagaaggtt accagcgtgt attcagtgac caatctattc taagaggttt tatcaattct
     4081 ctactatact cttttggatt tgcagcttta acagtattgc tatctgtgtt tacagcttat
     4141 cctctttcta agaaagactt ggttggacgt cgttggatta actacttctt gattgtgact
     4201 atgttctttg gtggtggttt agtcccaact tacttgctcg taaaagaatt gggaatgctc
     4261 aatactccat gggcaatcat tgttccaggt gctgtcaatg tttggaatat tattcttgct
     4321 agggcctatt tccaaggatt gcctgaagaa ttagttgaag ctgctgtcat tgatggtgca
     4381 aatgatttac agattttctt caaaatcatg cttcctcttg caaaaccaat tatgtttgtt
     4441 ctcttcctct atgcttttgt aggacagtgg aactcatact ttgatgcaat gatttatatc
     4501 aaggatccaa acttggaacc attgcaactt gtacttcgta aaattctcat tcagagccaa
     4561 ccaggtcaag acatgattgg agcacaagcg gctatgaatg aaatgaaacg tttagctgaa
     4621 ttgattaaat acgcaactat tgtcatttcc agcttgccat tgattgttat gtatccattc
     4681 ttccaaaaat actttgataa aggaattatg gctggttcac ttaaaggata aaaaaagaaa
     4741 aaataaaagg agttttctca tgaaattcaa aacattctca aaatcagcag ttttgttgac
     4801 agctagttta gcagtacttg cagcctgtgg ctcaaaaaat acagcttcaa gtccagatta
     4861 taagttggaa ggtgtaacat tcccgcttca agaaaagaaa acattgaagt ttatgacagc
     4921 cagttcaccg ttatctccta aagacccaaa tgaaaagtta attttacaac gtttggagaa
     4981 ggaaactggc gttcatattg actggaccaa ctaccaatcc gactttgcag aaaaacgtaa
     5041 cttggatatt tctagtggtg atttaccaga tgctatccac aacgacggag cttcagatgt
     5101 ggacttgatg aactgggcta aaaaaggtgt tattattcca gttgaagatt tgattgataa
     5161 atacatgcca aatcttaaga aaattttgga tgagaaacca gagtacaagg ccttgatgac
     5221 agcacctgat gggcacattt actcattccc atggattgaa gagcttggag atggtaaaga
     5281 gtctattcac agcgtcaacg atatggcttg gattaacaaa gattggctta agaaacttgg
     5341 tcttgaaatg ccaaaaacta ctgatgattt gattaaagtc ctagaagctt tcaaaaacgg
     5401 ggatccaaat ggaaatggag aggctgatga aattccattt acatttatta gtggtaacgg
     5461 aaacgaagat tttaaattcc tatttgctgc atttgatata ggggataacg atgatcattt
     5521 agtagtagga aatgatggca aagttgactt cacagcagat aacgataact ataaagaagg
     5581 tgtcaaattt atccgtcaat tgcaagaaaa aggcttgatt gataaagaag ctttcgaaca
     5641 tgattggaat agttacattg ctaaaggtca tgatcagaaa tttggtgttt actttacatg
     5701 ggataagaat aatgttactg gaagtaacga aagttatgat gttttaccag tacttgctgg
     5761 accaagtggt caaaaacacg tagctcgtac aaacggtatg ggatttgcac gtgacaagat
     5821 ggttattacc agtgtaaaca aaaacctaga attgacagct aaatggattg atgcacaata
     5881 cgctccactc caatctgtgc aaaataactg gggaacttat ggagatgaca aacaacaaaa
     5941 catctttgaa ttggatcaag cgtcaaatag tctaaaacac ttaccactaa acggaactgc
     6001 accagcagaa cttcgtcaaa agactgaagt aggaggacca ctagctattc tagattcata
     6061 ctatggtaaa gtgacaacca tgccagatga tgccaaatgg cgtttggatc ttatcaaaga
     6121 atattatgtt ccttacatga gcaatgacaa taactatcca agagtcttta tgacacagga
     6181 agatttggac aagattgccc atatcgaggc agatatgaat gactatatct accgtaaacg
     6241 tgctgaatgg attgtaaatg gcaatattga tactgagtgg gatgattaca agaaagaact
     6301 tgaaaaatac ggactttctg attacctcgc tattaaacaa aaatactacg accaatacca
     6361 agcaaacaaa aactagaggt tgattatggg agataagaaa tacacagtag aaaaagccaa
     6421 tcgttttata gcagaaaata aacatctcgt taatactcaa tataagcctg aagaacattt
     6481 ttcagctgag attggttgga tcaatgatcc aaatggattt gtctattttc gtggagaata
     6541 ccatctcttt tatcaattct atccatatga tagtgtttgg ggacctatgc actggggaca
     6601 tgctaaaagt aaggacttgg tgacttggga gcacttgcca gtggcacttg ctcctgacca
     6661 agattatgac cgaaatggtt gtttctcagg ctctgccatt gtcaaggatg atcgcctctg
     6721 gctcatgtac actgggcata tcgaagaaaa aaccggtgtc cgccaagtgc aaaatatggc
     6781 attttcagat gacgggattc actttgaaaa gatttcccaa aatccagttg taactggaac
     6841 agacttgcca gatgagttga ttgctgctga tttccgtgat ccaaaactct ttgaaaaaga
     6901 tggacgctat tactccgtag tagctgtcaa acacatggat aatgtgggct gtatcgttct
     6961 actagggtcc gataacctag tagaatggca gttcgaatcc atctttttaa aagggggaga
     7021 acaccaaggc tttatgtggg aatgcccaga ttacttcgag ttagatggga aagattgcct
     7081 tattatgtca cccatgcgtt atcagcgtga gggagactca tatcataaca tcaactcatc
     7141 gcttttgttc acgggtaagg tagattggag agaaaaacgt tttatcccag aatcagttca
     7201 agaaattgat catggccaag acttctatgc gcctcaaaca ttgttggacg atcaaaatcg
     7261 tcgtatcctg attgcttgga tgcagacatg ggggcgtacc cttccaaccc atgaccaaga
     7321 acacaaatgg gcatgtgcca tgactttacc tagaattcta agattggaag atggcaaact
     7381 aagacaattc cctgttaaaa aaggccaata tcaaatccaa atagataaag attgtcatta
     7441 ccacttagga aatgatatag attatcttga atttggttat gacagtaatg cgcagcaagt
     7501 ttacattgat cgtagccatc ttattcaaaa aattctaggt gaagaagaac aggacactag
     7561 tcgacggtat gtagatattg aagctaaaga attggaagtt gttctagata aaaattccat
     7621 cgagattttt gtcaatcaag gtgaagcaag cttgactgca acttattact taacggtgcc
     7681 agctgagcta tcacgaattg attaaaaatt aagttatttc tcctaaagaa aaagttctct
     7741 ttctaaaata gtggaaagag gactttttgt gttttgggta tataagctta gtttatggta
     7801 tttgtaaaat tggtgttgga ttatgattta agctagtttt ctaaagaatt tgaaaaaaat
     7861 tttatttaag caaaaaaagc cctatattat aagacttttc ctgttgtatt tagatgcccc
     7921 ctacagggat cgaacctgtg acccacggat taagagtccg ctgctctgcc agctgagcta
     7981 aggaggcaaa gaaaaaagct gtattggtgc cgaaacttca cggtttgtat tgaacccgcg
     8041 caattaagca ggtgggcaac tcgctctaac tgaagctgtt tccgtgtgag acggcctaca
     8101 tgctgttaga agacttttgt ttccctaata atacaaaaaa tagtcggtca acacttaagt
     8161 gtgaagtcgt acaccacagc gtttctatac ttatatgata ccactttttc aaaaaaaatc
     8221 aagaggaaag tgcaattttt tgaaaaggat ttcagatttt tcgcaaacgg tcgatagctt
     8281 cctttctttg agccaaagcc cgttcatatt taccagtatc ttctgcttgg aaatagtgat
     8341 gattacgaat tttttctggc agatagtctt gcttgaccca atttccagga tagttgtgtg
     8401 gatagagata gtcttgggca ttccccagtt ccttgcttcc actgtagtgc ccatcacgta
     8461 ggtgtcgcgg aataggcaag tgccctgatg ttttgaggtc agtaagtgcc ttatccatag
     8521 ctacataggc tgagttggat tttggagaaa gggccaaatc aatcacgaca ttggcaatga
     8581 gaatgcgggc ttctgggaac ccaatcttct gggcagcatc cagagcagtc acggtatgaa
     8641 tctgggcctc aggattggct aagccgatat cttcataggc gataacagtc aagcgacgag
     8701 cgagactagg cagatcccca gcctcaatca agcgggcagc atagtggaga ctggcatcca
     8761 catctgagcc acggatagac ttttgcaggg cagatagaac atcatagtga ccgtctccat
     8821 ccttgtccat agtgatgtag cttctctgaa gactattttc catgatgtct aaggtgatgt
     8881 ggcgaatgcc ctcgtcattc tcaggggtag agagaacagc caagtccagt gagttaaagg
     8941 cagagcgaag gtctccgttt gtagaggttg cgatgaaatc cagcgcatcc tcatctagtt
     9001 ctattggaaa atcaaaacca cgttcagggt tacttagagc tatctgcagg gcctctttga
     9061 cgtcttggtt agacagaggt tccaactcaa aaatttgaac acggctacga atggcaggag
     9121 tgacggaaaa gaaaggattt tcagttgttg ctccaatcat gatgaccagt ccactttcca
     9181 agagaggcaa gaggaagtct tgcttggtct tatctagtcg atgaatttcg tctagcaata
     9241 ggacgagacc accagaaaat ttagcttctt ccgagatttc ttgcagtcgc tttttactat
     9301 caactgtcgc attgaaagtt cgaaaggcat acttggtcgt tccagcgatg gcagaggcaa
     9361 tactggtttt gccgattccc ggagggccat atagaatcat ggaggacagg cggttggctt
     9421 ccaccatgcg gcggatgatt tttccaggtc cgaccagatg ctcctgaccg atgacctggt
     9481 cgatggtttt agggcgcatg cgaagcgcga gattgtctgg catagtagtc ctttctagtg
     9541 tggatttgag tagaatgact catctactat atcttactat gtccattcta gcctattagt
     9601 tgtgatattt caatggtttt gtaataatca gggagtgaga tagaatcttt tttactattt
     9661 aatttaatga ggagaggtat cagcatgaga gatttgattt tccttaaagc tcaaaatagg
     9721 atagttgagc ctaaagaagt ggaagtgctg acttgagaaa taatattgct aaatgtcatt
     9781 gtatgaacta taatgaaaag agaggtgata agcaatggaa atgatggacc aagtcaggaa
     9841 attttgattt ttacaaaaca aattcgtcat tggattctta gtgatcaagt tatttcaggg
     9901 aaaagaaaac ttttcttccg ggaagatact ccaaaagaga ttttagattt gtacgaaaac
     9961 attaaatcta aacttgattt tgcttaccaa gaagtttatt ctaataatgg gttgaaaaaa
    10021 tatgaaaaat agaataattg atgtttttga agtagtaaat cgcatccttg taataactgt
    10081 tgaaaatcct gatttcgaag acttgagagt taatcatact caatgaaaat caaagagcaa
    10141 actaggaaac tagccgcagg ctgtacttga gtacggtaag gcgacgttga cgtggtttga
    10201 atttgatttt cgaagagtat cagtttgtaa aaattggaga taaaaaatat agagtacgca
    10261 gtgttcctat gattcattca actccgcctc aatctgtctt agatcgagat acttttacaa
    10321 ttgactatac agatgatgaa ttgctcgata aagaagcagt ttttactact cattagaaaa
    10381 ataggtctga ataaattggc ttcccttaga accacatcta ggggctttta tgtataatag
    10441 aataataagt atcactcctt tacaatacgt gtaacacgtg ttataatggt gttgtcagga
    10501 ggtaaaagcg ctatgcctat gacacaaaaa gagatggtta aactccttac ggcccatggt
    10561 tggataaaga ctagaggcgg taaaggctcc catattaaaa tggagaagca aggggaaaga
    10621 cttatcacaa tccctcatgg tgagctgaat aagtacactg aaagagggat aagaaagcaa
    10681 gctgggttgt aaaattcagc ccctgttttt tgatatggag gtagtgaaat gttagttacg
    10741 tatccagctt tattttatta tgacgacaca gacggaacag aagcgactta ttttgtccat
    10801 ttcccagatt ttgaatactc agctacacaa ggagagggga tttctgaggc tttggctatg
    10861 gggtcggagt ggctagggat aactgttgca gatttgatag agagtgatgg agagttacct
    10921 cagccatcag atatcaatag cttgtcttta attgataatg atccttttaa agatgatgaa
    10981 gatttcgtgt caacctatga ccttgataaa tcttttattt ctatggtatc tgttgatgta
    11041 tcagaatacc taggaagtca ggaacccatt aaaaagactt tgactatacc aaaatgggca
    11101 gataagttgg gacgagaaat gggacttaac ttttctcaga ctttgacaga cgctattgca
    11161 gataagaaag ttcaagccta agattaagcg tggtatcgtg gtaatagtca ataaaaaagc
    11221 acgtccactt gtgctagtta ctcgcctatt gattttatag atttattagc cctttcgagg
    11281 gctttttata ttgattttta tgagaaatga agaaatcaga cttttaagaa aatcactgat
    11341 accaagggtt taaatgaggt aatatggtat aattaggaca taaaataatt ttgtggtaag
    11401 atggtagtat ctattttagc atatttccga gcaatcgggg cgattaaaga gtcgcataga
    11461 aagaggacaa aatggcaaca tacggatttt tagatgtttt agaggaagag ttggacaaga
    11521 actttccctt tgactttgag attagctggg acaaacgcaa ctatgcggta gaagtgagtt
    11581 ttctattgga agcgcaaaat gctgcaggtg tggagatggt ggatgaagac ggagaggttt
    11641 catcagatga cattcttttt gaggaagcgg tccttttcta caatcctgcc aagtcaacag
    11701 tcaatgagga agactatttg actgttattc cttacctgcc taaaaaagga ttttcccgtg
    11761 aatttttagc ttattttgcg cttttcctta aagatactgc tgaggttggg ctagatgccc
    11821 tcatggactt tttggaagat ccagaagcag aggaatttgt tatggaatgg aatcaagaag
    11881 tctttgaaga aggaaaagtt ggcttggaag agggagaatt ttacccttat ccaaaatact
    11941 aggagttggt tggaggtgtt atgaagaaaa ttgggactta tttggtttat gtgctagctg
    12001 ttgtctttat tatgctagct tttgcttgtg gaacaatcgc atttgcagag ttggggtatt
    12061 ccgcagtttt agcctttact tttggttatg cctttgctct tctaagcatg tatttaatct
    12121 ttattcttca tgagctgggt catgcttttt gtggctactt gacaggctat cggctggtgg
    12181 cttttggatt aggacatttt attttgacca aaaagtcagg caggtttcat cttagtagaa
    12241 cagccattct gaaaaatgtt ggtgctcaat acattggttt aaaagaggat gaaagcgatc
    12301 aaagaatcat cctgatgctt tcaggaggct tgatggttca tctcggcttg atattattgg
    12361 cgatattgtt tggatttttg acaagaagct ggtattttgc agggacttgg atttttctta
    12421 atttatcttt cttcctaaat aacattttac cagtcgacat caccgatgga gcaaaaattt
    12481 gggaattact acaacaccct gaaaatacca aatacgccta cctggtattg agacattctg
    12541 cccagacctt gctggctcct caagaatatg atttgaaaga ctttgttcaa gcagttcctg
    12601 aggatgcacg agggagtttt gcggatggtg tattaggtat gcaaggtgaa gtttccattt
    12661 tggaagggaa ggaagaagta gctaaacagc agtttcaagc attacttgag aggacaacta
    12721 ctccgatgat gcagacagtt gcccaactat ccctgcttca tatcgccttg ttggaaggag
    12781 attttgagca agcggagcaa tatgccagta ttcgacaggt caaatcgttt ctgtctctca
    12841 aactgtccaa tcttcaagtg atacaagcct ggtatcaatt taaggtaagg aaagatgtgg
    12901 ttcaaactca caaggctatg aagattgcta gacagaaaat ggatagtagt cgaatgttga
    12961 gggacgagaa acgctattat gaaaacttgt tagcagagct ggaaaaggaa atgttagaag
    13021 gaactgaaga tggaactaga aatttctgat ttcccaggct gtaagattgc tttgttttgt
    13081 ggggataagc ttttgactat cttacgcgat gataaggcaa gcattccctg ggccaatatg
    13141 tgggaactgc caggtggggg aaagagtgtc agggaaaatc tgatatagtt ttgcattaaa
    13201 agaatatcct ttcaaggtta ttctttttta attttgtccc aaaataattg actttgtccc
    13261 gaaaatatag tattatttgt ataaggagga atgaatcatg aaaaaatcag atgttcttga
    13321 tttaataaag tatcattatg agggcagaga gacagaattt agaaatcaat ccatagcaat
    13381 tgctcggaac ttcaataaac atggtgatac acaaatagca caatatatta tggggttaat
    13441 gtctcaaagt gatagattca tgccacaaat agaaaatcct agtgagtatt tgactcctgc
    13501 taaactagat attggtcctc tcccattgcc tctttcaatt atgaatgatt taaaaggaat
    13561 aataaacgct gtcaatcatc atattggaat aaataaattt ttatttgtgg gatctccagg
    13621 tactggaaaa actgaaagtg taaagcaggt ggctagactt attggcaagg aattacttgt
    13681 agtagatttc agtcacttag tagatagtaa gctagggcaa acagtcaaaa acttagcaac
    13741 tctttttaat gaaatcaata atcttccttt caagcaaaat tatatcatcc tatttgatga
    13801 aattgattcc atagtgttgg atagggttaa tcagaatgat ttaagagaaa tgggacgagt
    13861 gacttctgcc tttttaaagg agttggatag gctgtcacca gaaattgtat taattgcaac
    13921 aacaaatctt tttgaaaatc ttgataaagc agttacgaga agattcgatg ccataattga
    13981 ctttgaccgt tatactgatg aagataaagt agaagtagct actattattt taaatgagtt
    14041 attaaagcaa tttaagaatg tagctagaga tttaaaatta tttaaaaaaa ttatcaatag
    14101 tgccaatgta ataccgaatc ctggtgattt gagaaactca ataagaacgt cattggcatt
    14161 tagtgatcca tcagatccgc atgattacca aaaacgcctg ctaagaagtt tgcataatgg
    14221 tagaaattta tctatttcta aattatcgaa gctaggtttt actgttagag aaattgagat
    14281 tttgacaggt gtttctaaga gtagtgtatc acgagagtta agcgaggatt aaaatgaata
    14341 cattattgac attacgaggt aaaagcttta cacaaaaatc aagaaa
//
LOCUS       DAVHIZ010000046        14178 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.048, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000046 DAVHIZ010000000
VERSION     DAVHIZ010000046.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 14178)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14178)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14178
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.048"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            81..878
                     /locus_tag="VVO18_001580"
     CDS             81..878
                     /locus_tag="VVO18_001580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254803.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="formate/nitrite transporter family protein"
                     /protein_id="HEU5586701.1"
                     /translation="MVSSEFISKIEFACNKKESLYSQSKFKYAIRSMFAGAFLTFSTA
                     AGAVGADLINKIAPGSGRFLFPFVFAWGLAYIVFLNAELVTSNMMFLTAGSFLKKISW
                     RKTAEILLYCTLFNLIGALIAGWGFAHSAAYANLTHDSFISGVVEMKLGRSNELVLLE
                     AILANIFVNIAILSFILVKDGGAKLWLVLSAIYMFVFLTNEHIAANFASFAIVKFSVA
                     ADSIANFGVGNMLRHWGVTFIGNFIGGGLLMGLPYAFLNKNEDTYVD"
     gene            1026..1148
                     /locus_tag="VVO18_001581"
     CDS             1026..1148
                     /locus_tag="VVO18_001581"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001855084.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine sulfhydrylase"
                     /protein_id="HEU5586702.1"
                     /translation="MTCDFKFETLQLHAGQVVAPATKSRAVPIYQTTFFVFDDT"
     gene            1170..2210
                     /locus_tag="VVO18_001582"
     CDS             1170..2210
                     /locus_tag="VVO18_001582"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001231001.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="O-acetylhomoserine
                     aminocarboxypropyltransferase/cysteine synthase"
                     /protein_id="HEU5586703.1"
                     /translation="MRKPGNIYTRITNPTTAALEGGVEALATASGMTAVTYTILAIAH
                     AGDHVVAASTIYGGTFNLLKEPLPRYGITTTFFDIDNLEEVEAAIKDNTKLVLIETLG
                     NPLINIPDLEKLAEIAHKHQIPLVSDNTFATPYLINVFSHGVDIAIHSVTKFIGGHGT
                     TIGGIIVDSGRFDWTASGKFPQFVDEGPSCHNLSYTRDVGAAAFIIAVRVQLLRDTGA
                     ALSPFNAFLLLQRLETSSLRVERHVQNAETIVDFLVNHPKVEKVNYPKLADSPYHALA
                     EKYLPKGVGSIFTFHVKGGEEEARKVIDNLEIFSDLANAADAKSLVVHPATTTHGQLS
                     EKDLEAAGVTPN"
     gene            2381..3655
                     /locus_tag="VVO18_001583"
     CDS             2381..3655
                     /locus_tag="VVO18_001583"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2130 domain-containing protein"
                     /protein_id="HEU5586704.1"
                     /translation="MNEIKCPNCGEVFTVNESQYAELLSQVRTAEFDKELHDRMKQEL
                     ALAEQKAMNEQQTKLAQKDQEIAQLQSQIQNFDTEKELAKKEVEQTSHEALLAKDKEV
                     QLLENQLATLRLEHENQLQKTLSDLEKERDQVKNQLLLQEKENELSLASVKQNYEAQL
                     KAASEQVEFYKNFKAQQSTKAIGESLEQYAESEFNKVRSFAFPNAYFEKDNKVSSRGS
                     KGDFIFRECDENGVEIISIMFEMKNEADGTEKKHKNADFYKELDKDRREKNCEYAVLV
                     TMLEADNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVRE
                     QNIDITHFEEDLDAFKLAFAKNYNSASTNFGKAIDEIDKAIKRMEEVKKFLTTSENQL
                     RLANNKLEDVSVKKLTRKNPTMKAKFEALKGE"
     gene            3665..4543
                     /gene="truB"
                     /locus_tag="VVO18_001584"
     CDS             3665..4543
                     /gene="truB"
                     /locus_tag="VVO18_001584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007516878.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA pseudouridine(55) synthase TruB"
                     /protein_id="HEU5586705.1"
                     /translation="MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGV
                     LPIAVGKATRMVEFMQDEGKIYEGEITLGYSTKTEDASGEVVAETPVLSLLDEKLVDE
                     AIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVERPERQVTIYQFERTSPISYDG
                     QLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGLQLEDALALEEIAE
                     KVEAGQLDFLHPLEIGTGDLVKVFLTPEEATEVRFGRFIELDQTDKELAAFEDDKLLA
                     ILEKRGNLYKPRKVFS"
     gene            4784..5082
                     /locus_tag="VVO18_001585"
                     /pseudo
     CDS             4784..5082
                     /locus_tag="VVO18_001585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985087.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin immunity protein"
     gene            5190..5828
                     /gene="udk"
                     /locus_tag="VVO18_001586"
     CDS             5190..5828
                     /gene="udk"
                     /locus_tag="VVO18_001586"
                     /EC_number="2.7.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uridine kinase"
                     /protein_id="HEU5586706.1"
                     /translation="MQNRPIIIGVTGGSGGGKTSVSRAILSHFPDEKISMIEHDSYYK
                     DQSHLTFEERVKTNYDHPFAFDTDLMIEQIKELLAGRPVDIPTYDYTEHTRSSKTYRQ
                     EPQDVFIVEGILVLEDKRLRDLMDIKIFVDTDDDVRIIRRIKRDMEERGRSLDSVINQ
                     YLGVVKPMYHQFIESTKRYADIVIPEGVSNTVAIDLLTTKIAKILEEARNSK"
     gene            5956..7296
                     /locus_tag="VVO18_001587"
     CDS             5956..7296
                     /locus_tag="VVO18_001587"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="HEU5586707.1"
                     /translation="MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQY
                     FSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIGRVQVYEPSGNYSIIIEKAEPDG
                     VGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
                     PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVV
                     RAIFESRLPVISSVGHETDVTLADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEK
                     RMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDN
                     KQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLM
                     LDTSRIVARGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI"
     gene            7274..7486
                     /locus_tag="VVO18_001588"
     CDS             7274..7486
                     /locus_tag="VVO18_001588"
                     /EC_number="3.1.11.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="HEU5586708.1"
                     /translation="MSKQKKFEENLAELETIVQSLENGEIALEDAITAFQKGMVLSKE
                     LQATLDKAEKTLVKVMQEDGTESDFE"
     gene            7483..8358
                     /locus_tag="VVO18_001589"
     CDS             7483..8358
                     /locus_tag="VVO18_001589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743807.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polyprenyl synthetase family protein"
                     /protein_id="HEU5586709.1"
                     /translation="MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRP
                     FLLLEVLEALQVTIKPAHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFG
                     EAMAILAGDALFLDSYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
                     HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVL
                     DVTASFEEIGKTPQKDLQAEKSTYPALLGLEESIAFCNQTLDQANEKLEEIAQQLPFE
                     TESIVSVVESLRING"
     gene            8351..9166
                     /locus_tag="VVO18_001590"
     CDS             8351..9166
                     /locus_tag="VVO18_001590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001041085.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="HEU5586710.1"
                     /translation="MAKERVDVLAYKQGLFETREQAKRGVMAGLVVAVLNGERFDKPG
                     EKIPDDTELKLKGEKLKYVSRGGLKLEKALQVFDLSVDGATTIDIGASTGGFTDVMLQ
                     NSAKLVFAVDVGTNQLAWKLRQDPRVVSMEQFNFRYAEKTDFEQEPSFASIDVSFISL
                     SLILPALHRVLADQGQVVALVKPQFEAGREQIGKNGIIRDAKVHQNVLESVTAMAVEV
                     GFSVLGLDFSPIQGGHGNIEFLAYLKKEKSASNQILAEIKEAVERAHSQFKNE"
     gene            9159..9590
                     /locus_tag="VVO18_001591"
     CDS             9159..9590
                     /locus_tag="VVO18_001591"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU5586711.1"
                     /translation="MNKKERLEKIRRLVTDYQIGTQEEIVEHLKEAGITATQATVSRD
                     IKELGIVKIPLRDNTYVYELPKSIVKSLQLAEDNIESAELMDKMINLQVIPGNTAFVK
                     AQLIETFADKIFSCLTDDSSILVIARSGSLAEEIFEQVKNW"
     gene            9597..11264
                     /gene="recN"
                     /locus_tag="VVO18_001592"
     CDS             9597..11264
                     /gene="recN"
                     /locus_tag="VVO18_001592"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RecN"
                     /protein_id="HEU5586712.1"
                     /translation="MLLEISIKNFAIIEAISLNFEKGMTVLTGETGAGKSIIIDAMNM
                     MLGARATTDVIRHGAPKAEIEGLFSVENSRLLQEIFDEQGLELGDEIIIRREILQNGR
                     SISRVNGQMVNLSVLRAIGQHLVDIHGQHDHEELMRPQLHIQMLDEFGDAAFWDLKET
                     YQTSFDAYRKMRKQVLEVKKNQQEHKARIEMLEFQMAEIEAANLQAGEDLALNQERDK
                     LLNHKNIADTLTNAYSMLDNEDFSSLANVRSAMNDMESVEEYDPEYREISSSLSETYY
                     VLEDISKRLEAIIEDLDFDGNRLMQVENRLDLLHTITRKYGGTVDDVLLYFAKITEEY
                     NLLTGNNLSSEDMEAELKKLEVNLVNLAGQLASARHNLAQQLEAEIKQELQDLYMEKA
                     QFQVRFSKGKFSREGNKMVEFYISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRKE
                     GKTSIVFDEVDTGVSGRVAQAIAQKIHKIGQHGQVLAISHLPQVIAIADYQFFIEKIS
                     NDHSTVSTVRLLTVEERVEEVAKMLAGDDVTEAALTQARELLRNREK"
     gene            11266..11994
                     /locus_tag="VVO18_001593"
     CDS             11266..11994
                     /locus_tag="VVO18_001593"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000133310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein phosphatase"
                     /protein_id="HEU5586713.1"
                     /translation="MTDYYVIGDVHGKAEMLEDLLKTWDGQPQLLFLGDLIDRGEDSH
                     RVLEMVKDLVDNQGAICLSGNHEYMFLTWLDDPEESYDHYSRNGGDTTINSILGRPLD
                     APVDGVEDAKRVAAEASDLVEFIRQMPFVVETDKYIFVHAGIDLTLDDWHETTDYKKV
                     WLRKPFHGAENHTGKTIVFGHTPVYGLLQQERGTSELWTTEDGKIGMDGGAVYGGVLH
                     GIVFTDQGMTEHHFIENDGFVAED"
     gene            12073..13896
                     /gene="lepA"
                     /locus_tag="VVO18_001594"
     CDS             12073..13896
                     /gene="lepA"
                     /locus_tag="VVO18_001594"
                     /EC_number="3.6.5.n1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001047203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="elongation factor 4"
                     /protein_id="HEU5586714.1"
                     /translation="MNLEELKKRQGKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLA
                     ACEGAILVVDAAQGIEAQTLANVYLALDNDLEIMPIINKIDLPAADPERVRTEIEDVI
                     GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVTAPLKALIFDSVYDAYRGVILQ
                     VRVMDGVVKPGDKIQLMSNSKTFDVAEVGIFTPKAVGRDFLATGDVGYIAASIKTVQD
                     TRVGDTVTLATNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQ
                     FEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVIYKVNLTDGESMD
                     VSNPSEFPDPTKIATIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVN
                     VIYQIPLAEIVFDFFDKLKSSTRGYASFDYELSEYRPSKLVKMDILLNGDKVDALSFI
                     VHKDFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGHKIVARTDIKALRKNVLAKCYGG
                     DVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDEE"
     gene            complement(14055..14135)
                     /locus_tag="VVO18_001595"
                     /pseudo
     CDS             complement(14055..14135)
                     /locus_tag="VVO18_001595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
BASE COUNT         4181 a         2580 c         3380 g         4037 t
ORIGIN      
        1 ttttatgaaa tacagaaaac gcttcctaaa acctaaagtt tgtgatataa ttatcaagaa
       61 aaaagattta ggagtttatt atggtttctt cggaatttat ctcaaagatt gaatttgctt
      121 gcaataagaa agaaagtctt tatagtcaaa gcaaatttaa gtatgcgatt cgttcgatgt
      181 tcgcaggtgc atttttaacc ttcagtactg ctgcaggtgc agttggggct gacttgatta
      241 ataaaattgc accaggtagt ggacgcttcc tctttccatt cgtttttgct tggggcttgg
      301 cctacattgt ttttttgaat gccgagttgg tcacttcaaa catgatgttc ttgactgctg
      361 gtagtttctt aaaaaaaatc tcttggagaa aaacagctga gattttacta tactgtacct
      421 tgttcaacct tatcggagcc ttgatagcag ggtggggctt tgctcattcg gcagcctatg
      481 cgaatctgac acacgatagt ttcatctcag gtgttgttga gatgaagtta ggccgctcaa
      541 atgaattggt cttgcttgag gcgattttgg caaatatttt tgtaaatatt gcgattctgt
      601 catttatttt ggtcaaagat ggtggtgcca aactttggct tgtgttgtca gctatttaca
      661 tgtttgtatt cttaacaaac gagcacattg cggcgaactt tgcttctttc gcgattgtga
      721 aattcagtgt tgctgcggat tcaattgcca acttcggtgt tggaaatatg cttcgccact
      781 ggggtgtgac tttcatcgga aactttatcg gaggaggcct cttgatgggt cttccatatg
      841 ccttcctcaa taaaaacgaa gatacttatg tagattaaga aaatgagcac gattgagtcg
      901 tgcttttttc attttcaaaa taaggtaata gctatttctt atatcaaaat atagaaaact
      961 gatatttgta aactataact caaggtgcta caatatcctt aataaaataa tatggaggtc
     1021 accttatgac ttgtgatttt aaatttgaaa ctctacaact acatgctggt caagttgtgg
     1081 ctccagctac taagtctcgt gcagtgccga tttatcaaac aacatttttt gtttttgatg
     1141 acacgtagga aggtgccgat ctgtttgcct tgaggaaacc agggaacatt tatactcgta
     1201 tcaccaatcc tacaacagct gcccttgaag gtggtgttga agcgctagca acagcatcag
     1261 gtatgactgc agtgacttat actattttgg cgattgccca tgctggtgac catgtagtgg
     1321 ctgcttcgac tatttacggt ggaaccttca atcttttgaa agaacccctt cctcgttatg
     1381 gtatcacaac aacctttttc gatattgata atttggagga agtagaagca gctatcaaag
     1441 acaataccaa gcttgtcttg attgaaacct tgggtaaccc cttgattaat attccagacc
     1501 tggaaaaact ggcagagatt gctcataaac atcaaatccc acttgtgtca gacaatactt
     1561 ttgcaacacc ttatttgatt aacgtcttct ctcatggcgt tgacattgcc attcactctg
     1621 tgactaagtt tatcggtggg catggtacaa ctattggagg aataattgtc gatagtggtc
     1681 gttttgactg gacggcttca gggaaattcc ctcaatttgt tgacgagggt ccaagctgcc
     1741 acaatttgag ctatactcgt gatgtgggtg cagcagcctt tattatagct gttcgagttc
     1801 aattgcttcg tgatacaggt gcagccttgt caccattcaa tgctttcctc ttgctacaaa
     1861 gacttgaaac ctcttcactt cgtgtggaac gccatgtaca aaatgctgag acaattgttg
     1921 attttcttgt caaccatcct aaggtagaaa aggtaaatta tccaaaactt gcagatagtc
     1981 cttatcatgc cttggctgag aaatacttgc caaaaggtgt cggttcaatc tttaccttcc
     2041 acgtcaaagg tggcgaggaa gaagcacgca aggtcattga taatttagaa atcttttctg
     2101 accttgcaaa cgcggcagat gctaaatcgc ttgttgtcca tccagcaaca accactcacg
     2161 gtcaattgtc agaaaaagac ctagaagcag caggtgtcac accaaactaa attcgtttgt
     2221 caatcggtct tgaaaatgta gaagatttga ttgaagactt gcgcttggcc ttggaaaaaa
     2281 tttaaagtaa aagaagataa acagtgggct tcgactcact gtttttgatt ttccctcagg
     2341 catgatataa tggttaaaga agtctagaaa gaggaacgat atgaacgaaa tcaaatgtcc
     2401 caactgtggg gaagtcttta cagtaaatga gagtcagtat gccgaactct tgtcccaagt
     2461 gagaacggca gagtttgata aggaactaca cgataggatg aagcaggaac tggccttggc
     2521 tgagcaaaag gccatgaatg agcaacagac taaactggct cagaaggatc aagaaattgc
     2581 gcaattacag agtcagatcc aaaactttga tacagaaaaa gaattggcca agaaagaggt
     2641 tgaacagaca agccatgagg ctctcttggc taaggacaag gaagtacagc tcttagaaaa
     2701 tcagttggct accttgcgtt tggagcatga aaatcaacta caaaagaccc tttctgacct
     2761 agaaaaagaa cgggatcagg ttaaaaacca actacttttg caggaaaagg aaaatgaatt
     2821 atctttggct tctgttaagc aaaactacga agcccagctc aaggcagcta gtgaacaagt
     2881 cgagttttat aagaatttta aggctcaaca atctacaaaa gcgattgggg aaagcctaga
     2941 acagtatgca gagagtgagt ttaacaaggt tcgtagtttc gcctttccaa atgcttactt
     3001 tgagaaggat aacaaggtct cttcgcgtgg gtctaaaggg gactttatct tccgtgagtg
     3061 tgatgaaaat ggagttgaaa tcatttctat catgtttgag atgaaaaacg aagcggacgg
     3121 aacagagaag aagcacaaga atgcagattt ttacaaggaa ttggacaagg accgtcggga
     3181 gaagaactgt gagtatgccg ttttggtgac catgcttgag gctgataatg actactttaa
     3241 cacagggatt gttgacgtca gtcacgagta tgaaaaaatg tatgttgttc gtcctcaatt
     3301 ctttatccaa ttgattggtc tcttacgtaa tgcggcgcta aattccctaa aatacaagca
     3361 ggagttggcc ttggttcgcg agcaaaatat tgacattacg cattttgagg aagatttgga
     3421 tgcctttaag ctagcttttg ctaagaacta taattcagct tcgactaact ttggaaaagc
     3481 tattgatgaa atcgacaagg ccatcaaacg catggaagag gttaagaaat tcctgaccac
     3541 atctgaaaac caactccgtt tagctaacaa caaattggaa gatgtctctg ttaaaaaatt
     3601 gacccggaaa aatccaacaa tgaaagcgaa gttcgaagca ctgaaggggg agtagaaagc
     3661 aaaaatgaac ggtattatta acttaaaaaa ggaagcagga atgacctcgc atgatgcggt
     3721 ttttaaactg cgtaagattt tgggaaccaa gaaaattggt catggtggaa ccttggatcc
     3781 ggatgtggtg ggtgttttgc cgattgcggt tggcaaggcg acacgcatgg tcgagtttat
     3841 gcaggacgag ggtaagatct atgaggggga aatcactctg ggctattcca cgaagactga
     3901 ggatgctagt ggggaagtgg tcgcagaaac ccctgttttg tctctcttgg atgaaaagct
     3961 tgttgatgaa gcgattgcta gcttgactgg gcctattact cagattcccc ctatgtattc
     4021 ggcagttaag gttaatggtc gcaagctcta tgagtatgcg cgtgctggtc aggaagtgga
     4081 gcgtccagaa cgtcaggtga ccatttatca atttgagcga acaagtccga tttcttatga
     4141 tggccaactt gcccgattca cttttcgtgt aaaatgcagt aaagggacgt acatccgtac
     4201 tttgtcagtt gatttgggtg aaaagcttgg ttatgcggct catatgtccc atttgactcg
     4261 tactagtgct gctggcttac aattagaaga cgctcttgcc ttggaggaaa ttgctgaaaa
     4321 agtagaggct gggcaattag attttctcca tcctttagag attgggacag gtgaccttgt
     4381 caaagttttc ctaactccag aagaggctac agaagttcgc tttggtcgtt ttattgagct
     4441 agaccaaacg gacaaagaac tggctgcctt tgaagatgat aaattgttag ccattctaga
     4501 aaaacggggc aatctctata agccaaggaa ggtttttagc tagatcgttt aggaataaaa
     4561 atcgggtgat agataacaat tgcttgataa aaccccatac taatagtaga atggttttgg
     4621 gaattataat attccaattg ttgcgagttg taggtactca aataatctat atagaaattt
     4681 agaggtgtga aatgaagcaa tttaaaattc tttcagataa atatttagag tccattacag
     4741 gttctgatgg gaacttaggc ccaggatttg gtgtgataat tccatgatgc gaaatgagtt
     4801 tcgagaaagg gtggagcaac ttcttcaaca aaaagaaata aatgaaaata gtgagttgag
     4861 tcacctgttt cgtcttgcta tacaaaattt agacagaaat gaaaaatacc aatcggtcat
     4921 ggccaatttg agtcaagggt tgtcacttta cctcatgacg catcattacc aggcacctaa
     4981 gtctgtcatt gattttggtt tatggattaa gctcctagcc aggaaagagg gagactggct
     5041 ttcttgcaga tgcttgctca aaccctacag ggctttcgtt aaaactgtcg aacatcagag
     5101 ggaagactct ggtgtttttt gctgatgaga ctataaattt tgtaaaaaat gtgatagaat
     5161 agacgacgga taaaataacg gaggatagca tgcaaaatag accaatcatt attggagtga
     5221 caggtggttc tggtggtggt aaaaccagtg tttcaagagc cattttatcg cattttcctg
     5281 atgaaaagat ttccatgatt gagcatgatt catactacaa ggatcagtct catttgacct
     5341 ttgaagagcg tgtcaaaacc aactatgacc atccttttgc ctttgataca gacttgatga
     5401 tcgagcagat taaggaattg ttggcagggc gtccggtgga catcccgacc tacgactata
     5461 cagagcatac acggagtagc aagacctatc gtcaggaacc tcaagatgtc tttatcgttg
     5521 agggtatttt ggtcttggag gacaagcgtc tgcgcgattt gatggatatc aagatttttg
     5581 tggatacgga tgacgatgtg cgcattattc gtcgtatcaa gcgtgatatg gaggagcgtg
     5641 gccgtagcct tgatagcgtt attaaccagt acttaggtgt ggtcaaacca atgtaccacc
     5701 agtttatcga gtcaactaag cgttatgctg atatcgtcat tcctgaaggg gttagcaata
     5761 ccgtggctat cgacctgttg acgaccaaga ttgcaaagat tttggaagaa gctcgaaaca
     5821 gcaaataatc acatgtggag gccttgcctc ctttttctat ttttccctca taatggtaca
     5881 taaatggaga tttttaggca tatttttggt ataataatac ccatgaaaga gcaagtaaat
     5941 gaatagtagg tggagatgga aaagtattta tcggtaacaa ctttgaccaa gtatctgaaa
     6001 atgaaattcg ataaagaccc atacttggaa cgggtctatt taactggtca agtttccaac
     6061 tttcgtaaac gacctactca ccaatatttc tccctaaagg atgaccatgc agttattcaa
     6121 gcgaccatct ggtctgggat ttatcagaaa ttagggtttg acctggaaga aggaatgaag
     6181 atcaatgtga ttgggcgtgt acaggtctat gaaccaagtg gtaactactc catcatcatt
     6241 gaaaaagctg agcctgatgg ggttggggcg cttgcgattc agtttgaaca acttaagaaa
     6301 aaattgacag aagaaggcct gtttcaagaa cgcttcaagc aagctctgcc ccaattttct
     6361 aagagaattg gtgtagtaac cagccgtagt ggagccgtta ttcgagatat tatcacgacc
     6421 gtcagcaggc gattcccagg tgttgacatc cttctttatc cgaccaaggt tcaaggtgaa
     6481 ggggctgcgg aggaaattgc tagaaatatt gcgcgtgcta atcaacggga cgatttggat
     6541 ttgctcatta ttggtcgtgg aggtggttct attgaggatc tctgggcctt taacgaagaa
     6601 attgtggtac gagctatttt tgaatctcgt ttgccagtta tctctagtgt ggggcatgag
     6661 acggatgtga ccttggcaga ttttgtggca gatcgacgcg ctgcaacgcc aacagcggcg
     6721 gctgaactgg caacacctgt gaccaagttg gatgtattag ctcatttgca aaatcaggaa
     6781 aaacggatgg taacggcagt ccgaaatgtt ctatctaaga aacaagaggc tttgaaaaaa
     6841 tgcagtcagt ctgttatctt tagacaacct gagcgcttgt atgacggtta tttgcaacgc
     6901 ttggaccaac tgcaactgcg tttgaaacaa agtttgcgaa ctcggatttc tgataacaaa
     6961 caattagttc aagcaagaac tcatcaatta gtacaattat cacctgttac caaaatccaa
     7021 cgctatcaag accgtttagg acagttggac aagctcttag gtagccaaat ggcgttagtt
     7081 tatgacgcca aggttgctga ggccaagcga ctttcggaag ctttgctcat gttggatact
     7141 agccgaatcg tggcgcgtgg ttatgctatt gtcaaaaaag aagagtccgt tgtagattcg
     7201 gttgagagtt tgaagaaaaa agaccaagta acgcttttga tgcgagatgg tcaagtagaa
     7261 ttagaggtta aagatgtcaa aacaaaagaa atttgaggaa aatctagcag aactggaaac
     7321 cattgtccaa agtttggaaa atggtgaaat tgctctggaa gatgcgatta ctgcctttca
     7381 aaagggcatg gtcttgtcaa aagagctcca agctacgctg gacaaggctg aaaagacctt
     7441 ggtcaaggtc atgcaagaag acggaacaga aagtgatttt gaatgaaaaa gcaagaaaaa
     7501 ttagctcttg tcgagtcggc tttggaagat ttttatggag accagcagtt tgcctctagt
     7561 ttacgggagt ctgttctcta ttctattcat gctggtggca agcgtattcg gccttttctc
     7621 ttgttagaag ttctggaagc cttgcaggtt accatcaaac ctgctcacgc gcaggtagct
     7681 actgccttag agatgattca tacagggagc ttgattcacg atgaccttcc tgctatggat
     7741 gatgacgatt atcgaagagg gcggttaacc aatcacaaga aattcggtga agctatggcc
     7801 attttggctg gagatgcctt attcttagac tcatatgcct tgattgcgca ggcagatttg
     7861 ccaagtcaga ttaaggtgga cttgattgcc aacttatccc ttgcttcagg tagtctgggt
     7921 atggtggcag ggcaagtttt ggatatggag ggcgaacacc agcacttgtc tttggaagaa
     7981 cttcagacta ttcatgccaa taagactggg aagttactag cctatccctt ccaagcggca
     8041 gctattatag ctgaattgtc acctgaaatg caggtgaagc tgaaaactgt gggtgaattg
     8101 attggacttg cttttcaagt cagagatgat gtactggatg tgacagctag ttttgaggaa
     8161 atcggcaaga cacctcaaaa ggatctgcag gcagaaaaat caacctatcc tgccctgttg
     8221 ggcttggaag agtccattgc cttttgtaac caaaccctgg atcaagctaa tgaaaaatta
     8281 gaagaaattg cccagcagct tccctttgaa acagaatcga ttgtaagtgt agtagaaagt
     8341 ttgagaatca atggctaagg aaagagtgga tgtactagct tataaacagg ggttgtttga
     8401 aacgagagag caggccaagc gaggtgtgat ggctggccta gtcgtagcag tccttaatgg
     8461 agaacggttt gacaagccag gagagaaaat tccagatgac accgaattaa aactcaaggg
     8521 ggagaaactc aagtatgtca gccgtggtgg tttgaaactg gaaaaggcct tgcaggtctt
     8581 tgatttgtcg gtggatggcg cgactacgat tgatatcggg gcctctactg gaggttttac
     8641 cgatgtcatg ctacagaata gtgccaagtt ggtctttgca gtcgatgttg gtaccaatca
     8701 gttggcttgg aaattacgcc aagacccacg agttgtcagc atggagcagt tcaatttccg
     8761 ctatgctgaa aagactgatt tcgagcagga gccgagcttt gccagtattg atgtgagttt
     8821 catttccctt agtctgattt tgccagcctt gcaccgtgtc ttggctgatc aaggtcaggt
     8881 ggtagcactt gtcaaacctc agtttgaggc aggacgtgag cagattggga aaaatggaat
     8941 tattcgagat gctaaggttc atcagaatgt ccttgaatct gtaacagcta tggcagtaga
     9001 ggtaggtttt tcagtccttg gcttggactt ttctcccatc caaggtggac atggaaatat
     9061 tgaattttta gcgtatttga aaaaagaaaa gtcagcaagc aatcagattc ttgctgagat
     9121 taaagaagca gtagagaggg cgcatagtca atttaaaaat gaataaaaaa gagagacttg
     9181 aaaaaattag aagattggtg acagattatc aaatcggcac gcaagaagaa attgtagaac
     9241 atttgaaaga agcaggtatc actgccactc aggcgacggt atcccgagat atcaaagagt
     9301 taggtattgt caaaattcct ttgagagaca acacctatgt ctacgaattg ccaaaatcaa
     9361 tcgtaaaaag tctgcaactg gctgaagaca atatcgaatc ggctgaattg atggataaga
     9421 tgatcaatct ccaagttatt ccaggaaata cggcttttgt aaaagctcag ttaatcgaga
     9481 cttttgcaga caagattttt agctgtttga ctgatgatag ctcgatttta gtcattgcca
     9541 gaagtggaag tctagcagag gaaatctttg aacaagtaaa aaattggtag gtctatatgt
     9601 tacttgaaat ttcgataaaa aactttgcca ttattgaggc tatttccctc aattttgaaa
     9661 aggggatgac tgtcctgact ggtgaaacgg gtgcagggaa gtcgattatc attgatgcca
     9721 tgaatatgat gttgggagct cgtgcgacga cagatgttat tcgtcatggt gcaccaaagg
     9781 cagagattga ggggcttttc tcagttgaga atagtcgtct tttacaggaa atttttgatg
     9841 agcaaggttt agaattaggt gatgaaatta tcatccgtcg ggaaatcttg caaaatggtc
     9901 gtagtatcag ccgtgtaaat ggtcagatgg ttaatctgtc tgttttgcga gctattgggc
     9961 aacatcttgt agatattcat ggtcagcatg accatgagga gttaatgcgt ccccaactgc
    10021 atatccagat gttggatgaa tttggtgatg ccgctttttg ggacttgaaa gaaacctatc
    10081 aaacgagttt tgatgcctat cggaaaatgc gcaagcaggt tctggaagtc aagaaaaacc
    10141 aacaggaaca caaggcacgt atcgaaatgt tggaatttca aatggcagag attgaggcag
    10201 caaacttgca ggctggagaa gacttggctc tcaatcaaga gcgagataaa ctcctcaacc
    10261 acaaaaatat tgcggataca ctgaccaatg cctacagtat gttggacaat gaagattttt
    10321 caagtctggc caatgttcgt tcagctatga atgacatgga aagtgtcgaa gagtatgatc
    10381 ctgaataccg tgaaatttca agctctctgt ctgagaccta ctatgtttta gaagacatta
    10441 gcaaacgttt ggaagctatc attgaggacc ttgattttga tggcaatcgc ctgatgcagg
    10501 ttgagaatcg tttggacctc cttcatacta ttactcgtaa gtatggtggg actgttgatg
    10561 atgttttgct ttattttgcc aagattacgg aagaatacaa tctcttgaca ggcaataatc
    10621 tttcgtctga ggacatggaa gcagagctta agaagttgga agtcaatctt gtcaatttgg
    10681 caggtcaact tgcttctgct cgtcataatt tggctcagca actcgaagct gagattaaac
    10741 aagaactgca agatctttat atggaaaaag cccagtttca ggttcgtttt agtaagggaa
    10801 aattcagtcg tgagggaaat aaaatggttg agttttatat ttcaaccaac cctggagaag
    10861 actttaaacc cttggttaag gttgcttctg gaggggaatt atctcgtctc atgttagcca
    10921 ttaagtctgc cttttcacgt aaagaaggca agactagcat tgtctttgat gaggtggata
    10981 cgggagtttc aggtcgtgtt gctcaagcta ttgctcagaa aattcataaa attggtcagc
    11041 atggtcaggt tttggctatc tcccatttgc cacaagtaat tgcgattgca gattatcaat
    11101 tctttattga gaagattagt aatgaccatt caacggtttc gactgttcgt ctcttgacgg
    11161 tcgaagagcg agtggaggaa gttgccaaga tgttggcagg tgatgatgtg acagaagcag
    11221 ccctgacgca agccagagaa ttgttgagaa acagggagaa ataagatgac agattattat
    11281 gtaattggag atgttcacgg aaaagctgag atgctggaag accttctcaa aacctgggat
    11341 ggtcagcccc agttgctctt tctaggtgat ttgattgaca gaggtgagga tagtcaccgt
    11401 gttcttgaaa tggtcaagga cttggtggac aatcaagggg ctatctgttt gtccggaaac
    11461 cacgagtata tgtttttgac ttggctagat gacccagaag aaagttatga ccattatagt
    11521 cgcaatggtg gagatacaac cattaactct atcctaggtc gtcccttgga tgcaccagtt
    11581 gatggagtag aagatgccaa gcgggttgcc gctgaagcgt cagacttggt cgaattcatt
    11641 cgtcaaatgc catttgtagt agagacagac aagtatatat ttgttcacgc aggtattgat
    11701 ttgactttgg acgactggca tgaaacaaca gattataaaa aagtatggct tagaaaacca
    11761 ttccacggag ctgaaaatca tactggaaaa accattgtct tcggtcatac accggtctat
    11821 ggtttgttac agcaagaacg cggtacatct gagctttgga ctacagaaga tggcaagatt
    11881 ggaatggatg gaggagctgt ttatggtggt gtccttcacg ggattgtctt tacagaccaa
    11941 ggaatgacag aacaccactt tatcgaaaat gacggctttg tcgctgaaga ttagtactcc
    12001 tagcagggta tggtcttgtc aaaatatcaa aaacaattta taataaatag ataccctgaa
    12061 aggaagagaa tcatgaactt agaagaattg aaaaaacgac aggggaagat ccgtaacttc
    12121 tctattatcg cccatattga ccacgggaaa tcaactctag cagaccgcat tttggaaaaa
    12181 acagagacgg tttcaagtcg tgaaatgcag gcccagcttt tggatagcat ggatctagag
    12241 cgggaacgtg gaattactat taagttgaat gccatcgagt tgaattacac tgcaaaagat
    12301 ggggaaactt atattttcca cttgattgac acaccagggc acgttgactt tacctatgaa
    12361 gtttcacgtt cgctagctgc ctgtgagggt gctattttgg tggtcgatgc ggctcaagga
    12421 attgaggctc aaactcttgc caacgtttat ctggctttgg ataatgattt ggaaatcatg
    12481 cctatcatta ataaaattga cctgccggct gcagatccgg agcgcgtgcg tacagagatt
    12541 gaagatgtga ttggtttgga tgccagtgaa gcagttttgg cttctgccaa ggctggtatt
    12601 gggattgaag aaatcctcga gcaaattgta gaaaaagtac cagcaccaac gggtgatgtg
    12661 acggcgccac ttaaggcctt gattttcgac tctgtttacg atgcttaccg tggggttatc
    12721 ctccaagtgc gtgtcatgga cggagtggtc aaacctggtg ataagattca gctcatgagc
    12781 aatagtaaga cctttgatgt ggccgaagtc ggtattttta caccaaaagc ggttggtcgt
    12841 gatttccttg cgactggtga tgttggttac attgcggcgt ctatcaagac ggttcaggat
    12901 actcgtgtgg gtgataccgt taccttggca accaatcctg cggcagaacc attacatggt
    12961 tataagcaga tgaatcctat ggtctttgcg ggtctctacc caatcgaatc aaacaagtac
    13021 aatgacctgc gtgaagcgct tgaaaaattg caactgaatg atgctagtct tcagtttgaa
    13081 ccagaaacat ctcaggcact tggatttggt ttccgttgtg gatttcttgg acttctccat
    13141 atggatgtta ttcaggaacg tttagagcgt gagttcaata ttgacctcat catgacagct
    13201 ccgtctgtta tttacaaagt taatttgacc gacggtgagt ctatggatgt gtctaaccca
    13261 tctgagtttc cagacccaac taagattgcg accattgaag agccttatgt caaggcgcaa
    13321 atcatggtac cacaggagtt cgtcggagca gtaatggagc tagctcagcg taagcgtggg
    13381 gactttgtga ctatggacta tattgatgat aaccgtgtca atgttatcta tcaaattcct
    13441 cttgctgaaa ttgtctttga cttctttgat aaacttaagt cttcgacacg tggttatgca
    13501 agctttgact acgaattatc agaatatcgc ccatctaagc tggtgaaaat ggatatcctt
    13561 ctcaatggag ataaggtgga tgccctcagc tttatcgttc acaaggactt tgcctacgaa
    13621 cgtgggaaac tcatcgttga taaactcaag aaaatcatcc ctcgccaaca atttgaagtt
    13681 ccaatccaag cggctattgg acacaagatt gtcgctcgta ctgatatcaa ggcccttcgt
    13741 aagaacgtac ttgctaaatg ttatggtggt gacgtttctc gtaagcgtaa actccttgaa
    13801 aaacaaaaag ctggtaagaa acgcatgaaa tccatcggat cagttgaagt tccgcaagaa
    13861 gccttcctca gcgtcttgag tatggatgaa gaataagtta tcagaaatgc ctttccttgt
    13921 tcacaggaaa tttatataag aatcaatagt aaagcaggct tagatggtct gcttttttag
    13981 tttttatact cttcgaaaat ctcttcaaac cacgtcagcg tcgccttacc gtatgtatgg
    14041 ttactgactt cgtcagtttc atctacaacc tcaaaactgt gttttgagta acctgcggct
    14101 agcttcctag tttgctcttt gattttcatt gagtattaga acagaaaaat gcttggagta
    14161 tttgtttgtg tgtttatt
//
LOCUS       DAVHIZ010000047        13895 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.049, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000047 DAVHIZ010000000
VERSION     DAVHIZ010000047.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13895)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13895)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13895
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.049"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(268..493)
                     /locus_tag="VVO18_001596"
                     /pseudo
     CDS             complement(268..493)
                     /locus_tag="VVO18_001596"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838792.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
     gene            1341..2213
                     /locus_tag="VVO18_001597"
     CDS             1341..2213
                     /locus_tag="VVO18_001597"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4300 family protein"
                     /protein_id="HEU5586715.1"
                     /translation="MKKSRKLATLGICSALFLGLAACQQQHATSEGTNQRQSSSAKVP
                     WKASYTNLNNQVSTEEVKSLLSAHLDPNSVDAFFNLVNDYNTIVGSTGLSGDFTSFTH
                     TEYDVEKISHLWNQKKGDFVGTNCRINSYCLLKNSVTIPKLEKNDQLLFLDNDAIDKG
                     KVFDSQDKEEFDILFSRVPTEATTDVKVHAEKMETFFSQFQFNEKARMLSVVLHDNLD
                     GEYLFVGHVGVLVPADDGFLFVEKLTFEEPYQAIKFASKEDCYKYLGTKYADYTGEGL
                     AKPFIMDNDKWVKL"
     gene            complement(2359..2703)
                     /locus_tag="VVO18_001598"
                     /pseudo
     CDS             complement(2359..2703)
                     /locus_tag="VVO18_001598"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            2846..3158
                     /locus_tag="VVO18_001599"
                     /pseudo
     CDS             2846..3158
                     /locus_tag="VVO18_001599"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007521917.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            3162..3878
                     /locus_tag="VVO18_001600"
     CDS             3162..3878
                     /locus_tag="VVO18_001600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000759776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU5586716.1"
                     /translation="MKKYFIGGLGSNAYHSKDFLQELDSQVYFLNPYEKHLRDETELK
                     SWFKNEIVEEESICLIGHSIGGDLARYFASEFEEVKKLILLDGGYLDLDKILPLDTEL
                     EETKNYIKSQIISDLDVLTSKEKSEAKHWSENMEKAVRQSYHWNVEYNRYELAINYEN
                     IEAILRLRRKIQAFKREVGDTLFISPRYPNEATWREEALKELPDYFDTIFLENFGHEL
                     YTQAPKEIASLMNEWLAYFL"
     gene            complement(4008..4823)
                     /locus_tag="VVO18_001601"
     CDS             complement(4008..4823)
                     /locus_tag="VVO18_001601"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000617844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR03943 family protein"
                     /protein_id="HEU5586717.1"
                     /translation="MIRFLVLAGYFELTIYLHLSGKLNQYINMHYSYLAYISMVLSFI
                     LAIVQLYIWMKQVKTHSHLNNRLAKMTSISLLAIPLVIGLTFPTVSLDSQTVSAKGYH
                     FPLSEGTDLAIQTSEGTTSQYLKPDTSSYFSKSAYEKEMRTAADKYLSQDSIQITNEN
                     YMEVMEAIYDYPDEFEGKTIQFTGFVYNDPSHANSQFLFRFGIIHCIADSGVYGLLTK
                     GNTRQYENNTWISAKGKLVNHYHKELKQNLPTLEIDSFTKVDKPENPYVYRAF"
     gene            complement(4820..5725)
                     /locus_tag="VVO18_001602"
     CDS             complement(4820..5725)
                     /locus_tag="VVO18_001602"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398535.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="permease"
                     /protein_id="HEU5586718.1"
                     /translation="MTAFQQLPSSVLQTGAIFLSIIIEALPFVLIGSIVSGLIEVYIT
                     PDKVYHFLPRNRWGRIFFGTFVGMFFPSCECGIVPIINRFLEKKVPSYTAVPFLVTAP
                     VINPIVLFATYSAFGNSFHVALLRALGSILVAVILGIFLGFFWQEPIQKENRLACYEH
                     DFSYLSSAKKVFQVFVQAIDEFFDTGRYLVFGCLFASIIQVYVPTRILTSISATPLFA
                     ILLLMILAFLLSLCSEADAFIGASLLSSFGLAPVLAFLVIGPMLDIKNILMMKNYLKA
                     RFISHFITIVTLVVLVYSLLIGVIL"
     gene            6137..8266
                     /locus_tag="VVO18_001603"
     CDS             6137..8266
                     /locus_tag="VVO18_001603"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359105.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding transcriptional accessory protein"
                     /protein_id="HEU5586719.1"
                     /translation="MDKKYEKISQDLGVTLKQIDTVLSLTAEGATIPFIARYRKDMTG
                     SLDEVAIKAIIDLDKSLTNLNDRKEAVLAKIQEQGKLTKELEEAILVAEKLADVEELY
                     LPYKEKRRTKATIAREAGLFPLARLILQNIVDLEKEAEKFVCEGFATGKEALTGAVDI
                     LVEALSEDVTLRSMTYQEVLRHSKLTSQAKDESLDEKQVFQIYYDFSETVGTMQGYRT
                     LALNRGEKLGVLKIGFEHATDRILAFFATRFKVKNAYIDEVVQQSVKKKVLPAIERRI
                     RTELTEKAEEGAIQLFSDNLRNLLLVAPLKGRVVLGFDPAFRTGAKLAVVDATGKMLT
                     TQVIYPVKPASARQIEEAKKDLADLIGQYGVEIIAIGNGTASRESEAFVAEVLKDFPE
                     VSYVIVNESGASVYSASELARQEFPDLTVEKRSAISIARRLQDPLAELVKIDPKSIGV
                     GQYQHDVSQKKLSESLDFVVDTVVNQVGVNVNTASPALLSHVAGLNKTISENIVKYRE
                     EEGKITSRSQIKKVPRLGAKAFEQAAGFLRIPESSNILDNTGVHPENYAAVKELFKCL
                     DIKDLNEEAQSKLKSLSVKEMAQELDLGPETLKDIIADLLKPGRDFRDSFDAPVLRQD
                     VLDIKDLVVGQKLEGVVRNVVDFGAFVDIGIHEDGLIHISHMSRKFIKHPSQVVAVGD
                     LVSVWVKKIDTEREKVNLSLLAPNETD"
     gene            8253..8702
                     /locus_tag="VVO18_001604"
     CDS             8253..8702
                     /locus_tag="VVO18_001604"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000778579.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SprT family protein"
                     /protein_id="HEU5586720.1"
                     /translation="MKLTDYVKQVSLEDFGRPFIHHVQWNRRLRSTGGRFFPKDGHLD
                     FNPKVYQKLGMEVFRKIVRHELCHYHLYFQGKGYQHKDRDFKELLKAVDGLRFVPSLP
                     NSNSKPLKLYRCQSCQQRYQRKRRIDTKRYRCGLCRGKLLLINQPED"
     gene            8761..9033
                     /locus_tag="VVO18_001605"
     CDS             8761..9033
                     /locus_tag="VVO18_001605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269704.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEU5586721.1"
                     /translation="MNSKFYKMRRNRMISGVLAGLSDKWNFDVTLVRFLFAIFTVANF
                     GLGVIIYIILASIMPTKEEIEAEMYGTGPRKRKEAQAIDDNEGWFW"
     gene            complement(9081..9245)
                     /locus_tag="VVO18_001606"
     CDS             complement(9081..9245)
                     /locus_tag="VVO18_001606"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586722.1"
                     /translation="MDEAGEILLILFKNQSANYVNFTLPTKLQPVAGFLVCTLIFIEY
                     KSKKALNQAV"
     gene            complement(9387..9578)
                     /locus_tag="VVO18_001607"
     CDS             complement(9387..9578)
                     /locus_tag="VVO18_001607"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000680763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586723.1"
                     /translation="MKHKEHILIGLLYLLSPFIGQLLVEHTHFIGTEFTGTAYVICWL
                     SVVISIHHFSKNVLSQQQK"
     gene            10006..10764
                     /locus_tag="VVO18_001608"
     CDS             10006..10764
                     /locus_tag="VVO18_001608"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000173375.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586724.1"
                     /translation="MTLLDVKHVQKIYKTRFQGNQVEALKDIHFTVEKGDYVAIMGES
                     GSGKSTLLNILAMLDKPSRGQVYLNGTDTATIKNSQASSFRREKLGFVFQDFNLLDTL
                     SVKDNILLPLVLSRRPITEMMKKLVVTAENLGINQLQEKYPYEISGGQKQRVAVARAI
                     ITEPEILLADEPTGALDSKSSAALLDVFDEINERGQTILMVTHSTAAASRAKRVLFIK
                     DGILYNQIYRGEKTERQMFQEISDTLTVMASEVN"
     gene            10766..12754
                     /locus_tag="VVO18_001609"
     CDS             10766..12754
                     /locus_tag="VVO18_001609"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000489335.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586725.1"
                     /translation="MFRLTNKLAVSNLIKNRKLYYPFALAVLLAVTVTYLFYSLTFNP
                     KIAEIRGGTTIQATLGFGMFVVTLASAIIVLYANSFVMKNRSKELGIYGMLGLEKRHL
                     ISMTFKELVVFGILTVGAGIGIGALFDKLIFAFLLKLMKLKVELVATFQTKVVITVLV
                     VFGLIFLGLMFLNALRIARMNALQLSREKASGEKKGRFLPLQTILGSISLGIGYYLAL
                     TVKDPLTALTTFFIAVLLVIFGTYLLFNAGITVFLQILKKNKKYYYQPNNLISVSNLI
                     FRMKKNAVGLATIAILSTMVLVTMSAATSIFNSSESFKKVLNPHDFGVSGQNVEKEDL
                     DKLLSQFASDKGYKIKEKEVFRYTYFAVANQEGTKLTIFEKGQNRVQPKTVFMVFDQK
                     DYENMTGQKLSLSGNEVGLFAKNEGVKEQKALTLNDHQFSVKEEFTKDFIVNHVPNQF
                     NILTADYNYLVVPDLQAFLDQFPDSAIYNQFYGGMNVNASEAEQLKVAEEYEKYLQKF
                     NAQLNTEGNYVYGSTLADASAQMSALFGGVFFIGIFLSIIFMVGTVLVIYYKQISEGY
                     EDRERFIILQKVGLDQKQIKQTINKQVLTVFFLPLLFAFLHLAFAYHMLSLILKVIGV
                     LDTTMMLIVTLSICAIFLIAYVLIFMITSRSYRKIVQM"
     gene            complement(12797..13375)
                     /locus_tag="VVO18_001610"
     CDS             complement(12797..13375)
                     /locus_tag="VVO18_001610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003070359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VIT1/CCC1 transporter family protein"
                     /protein_id="HEU5586726.1"
                     /translation="MDSNFAGRLNILRAGVLDANDGIISIAGGEYVSVSTPKDTEEAA
                     VSREKLLLDQDRELAKKSLYASYIQNGEFKTSAQLLTNKIFLKNPLKALVEEKYGIEY
                     EEFTNPWHAAISSFVAFFLRSLPPMLSVTIFPSDYRIPATVLIVGVALLLTGYTSARL
                     GKAPTKTAMIRNLAIGLLTMGVTFLLGQLFSI"
     gene            complement(13371..>13895)
                     /locus_tag="VVO18_001611"
     CDS             complement(13371..>13895)
                     /locus_tag="VVO18_001611"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001153874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="HEU5586727.1"
                     /translation="AGQSIEQRSEAINLRLENGHYEIDTVLLTRAKNYCLLVLTDRKS
                     RHQIIRLIPNKSAEVVNQALKLILKQHKILSITADNGTEFNRLFDVFSEEHIYYAHPY
                     ASWERGTNENHNRLIRRWLPKGTKKMTPKEVAFIEKWINNYPKKCLDYKSPREDFWMA
                     NLNLKFSVRNKSRN"
BASE COUNT         4223 a         2572 c         2870 g         4230 t
ORIGIN      
        1 gcattcttct cagctagtgt actaaggagt gtgtgcctga aaatatggga actaaggggc
       61 tggtttatcg gtttctctag tttagtattt gccttttgca aagtgatctt aaatgccttt
      121 ctctaaattt acatatcact attgtttaac aaaatctaat ctattttagg tcacttattc
      181 tttttttgaa atgtagaatg aactttttca aagtttttcg aatcttttaa aatctgtttg
      241 ttttatatcg ccattctccc ccctttttta attctcccta tatagcctga caactttccc
      301 gatggtacga atatggttgc tttcgtctag gtggatgtcg gggtattcgg gattgagttt
      361 ttttgaggta gccttggcgg agtttcttga catagttagc gccgtctact tggaagatgc
      421 cgatggtatt atagtcaatc tgtggggtat tcttgataaa taggtagtcg ctgtttctta
      481 tctttgcctc catggacttg ctgacgacat aagcgattgg gtcgtagtcg tctgggataa
      541 tggaaactcc ataactaaat cgtcgtcctg catcgagcgg ctacctgcag agataaacta
      601 cctaacacga gagtaagtag tctgtctgta gtcgtccagt ctgatgattt ttacgatcct
      661 tcgtttttct gcttatacag ttgcctctcg gcataggtta ggactttacc ttgtctgggt
      721 ggtgcccgtt ggtcgtagat agattggata tcgctaggag aatccttttg aactggagga
      781 aagagggcat caatcaagct actgaatact ttaactaagt caaatatagt atttttctta
      841 gtagacctaa cccttttttc ataatttcta atggtgtttt tacttatacc tatcttagta
      901 cccaattctt attgagtcca accattacta gtctatattg ttttatagtt gattgagttt
      961 ggaatagtac gctgtagctg ctaaaacatt tctaggaatt aatttgcctt tcctaataga
     1021 gttgttcata tcttatttca atctattata tttttcgcct ctaacaatcg caatctcttc
     1081 tttatctacg aacgaaatcg ctttctattt ttgtaagtaa agcatcacac gaaatccacg
     1141 aaaatgaaaa cctttgttgt gttttcgtaa aaaatttgtt gacagagcac gaaacgccta
     1201 ctataattaa atcaagttta aggaaataac aaaaaaacaa atcggaggga aagacgatga
     1261 acacattaaa tgagaaagta atcaatatct gtaaagcagt agttaaagaa actttaatcc
     1321 aagacattta ggagaaagaa atgaagaaat caagaaaatt agccacatta ggaatctgtt
     1381 cagccttgtt tttaggcttg gctgcttgtc aacaacaaca tgctacttct gagggtacga
     1441 atcaaaggca aagcagttca gcgaaagttc catggaaagc ttcatacacc aacctaaaca
     1501 accaggtaag tacagaagag gtcaaatctc tcttatcagc tcacttggat ccaaatagtg
     1561 ttgatgcatt ttttaatctc gttaatgact ataataccat tgtcggctca actggcttat
     1621 caggagattt cacttccttt actcacaccg aatacgatgt tgagaaaatc agtcatctct
     1681 ggaatcaaaa gaagggcgat ttcgttggga ccaactgccg tatcaatagt tattgtcttt
     1741 tgaaaaattc agtcaccatt ccaaagcttg aaaagaatga ccagttgctt ttcctagata
     1801 atgatgcgat tgataaagga aaggtctttg attcacaaga taaggaagag tttgatattc
     1861 tattttcgag agttccaact gaggcaacta cagatgtcaa ggttcacgct gaaaagatgg
     1921 aaacattctt ctcacaattt caattcaatg aaaaagctcg aatgctgtct gtagtcttgc
     1981 acgacaatct ggatggcgag tatctgtttg taggccacgt tggggtctta gtacctgctg
     2041 atgacggttt cttatttgta gagaaattga ctttcgaaga gccctaccaa gcgattaaat
     2101 ttgctagtaa ggaagattgc tacaagtatt tgggcaccaa gtatgcggat tatacaggcg
     2161 agggactggc taagcctttt atcatggata atgataagtg ggttaaactt taatagtgtt
     2221 atgatatgac agtaatctta ggatttttat ttctattttt gataagttgg tgggttattt
     2281 caatcgttaa tagccagaaa ccacgcaaaa atgaaacatt tattggctat gtccaaagat
     2341 acgatattga tgggaatggc tatcaatcat taccgtgtcc tcagaactga gaggagttct
     2401 tgaaatcgta aaaccacttt gaacaagagt tacttcaacc cattggctcc gacggattaa
     2461 gttgctttcg tgaataccaa aatcagccgc aatttgttca taagtgcggt attctcgcac
     2521 atattgaaga gtggccataa gaagatcttc taggcttaat ttaggttttc gtccaccttt
     2581 tgcgtgttta agttgataag ctgtttttaa tacagctaat atctcttcaa aagtcgtgcg
     2641 ctgaacacca acaagacgtt taaatcgtgc atcagttagt tgtttacttg cttcataatt
     2701 catagaacta ctataccata ttttgtttcg caggaagtct aatgctaaaa tcttatcagt
     2761 gagaagattt cttaaagttt attctttgta gtttcatctg tattagtaca taatttaact
     2821 tagagaaaat aggaggacta atcgaatgga attaaaagat tttacagaaa aagaacagga
     2881 aatgattaag aaaaggctta caatgtctaa tattagtgac aaagaaacta ctgagaagat
     2941 tctggcgcta gtcccacaag acttgattaa gcgaatcccg ttttttgtca gaaaacatgc
     3001 tacaacacgt acgattaaac gcatttcaat tgaataccct gaactctacg ctgtagctca
     3061 aacaagtggt gagattccag aaaaaaaaac gcgaagaatt gcgtcagatt atcacaacta
     3121 tctttgaaca aaagatgaat aagcatagta ttaagtagag aatgaaaaaa tattttattg
     3181 gcggtttggg aagcaatgcc tatcatagca aggattttct tcaagaacta gattcgcagg
     3241 tctattttct aaatccatat gaaaagcatc ttcgagatga aacagaattg aaatcatggt
     3301 ttaaaaatga gattgtagag gaagaatcta tctgtctgat aggtcattct attggaggcg
     3361 atttagctcg ttatttcgca tcggaatttg aagaagtaaa gaaactgatt cttttggatg
     3421 gtggctatct agatttagat aagattttac ctttggatac agagttagag gaaactaaaa
     3481 attatatcaa atctcaaatt atttcggact tagatgttct tacttctaaa gaaaaatctg
     3541 aagcaaagca ttggtcagaa aatatggaga aagctgtaag acagtcctat cactggaatg
     3601 ttgagtataa tagatatgag ttggctataa attatgaaaa tatagaagcg atactccgcc
     3661 tacggagaaa aatacaagct tttaagagag aagtgggaga taccttgttt attagtcctc
     3721 gctatcctaa tgaagctaca tggagagagg aagccctaaa agaattgcca gactattttg
     3781 atactatttt tttagaaaac tttggccatg agctttatac tcaagcacct aaagaaatcg
     3841 ctagtctaat gaatgagtgg ctcgcttatt ttctatgagc tacttgtatt gctggaaatg
     3901 gtataagatg aaaatctaca agtcactaat tttcatataa ccaaaaaacg aacaggctct
     3961 ttttctgtta ttcagaagag aacttgttcg tttttatctt gattttctta aaaagctcta
     4021 tatacatagg gattttctgg tttatcgact ttggtaaagc tgtcgatttc caaggttgga
     4081 aggttttgtt tgagttcttt atggtagtga ttgaccagtt ttcctttggc tgaaatccaa
     4141 gtgttgtttt catactgccg ggtattgccc ttggtcagca atccatagac accagaatct
     4201 gcgatgcagt gaataatgcc gaagcggaac agaaattggc tattagcatg actggggtca
     4261 ttatagacaa agcctgtgaa ctggattgtc ttaccctcaa attcatctgg atagtcgtag
     4321 atagcctcca tgacctccat atagttttca ttagtgatct gaatactatc ttgggataag
     4381 tatttatccg ccgccgttcg catttccttt tcataggctg attttgaaaa ataagaactg
     4441 gtatctggtt tcaaatattg gcttgtcgtc ccttcgcttg tctgaatggc tagatccgtt
     4501 ccttccgata gggggaaatg ataaccttta gcagaaacgg tctgagaatc caagctaaca
     4561 gttgggaaag ttaagccgat gacaagtgga atagccagaa gagaaatact cgtcatcttg
     4621 gctaatcggt tgttcagatg actgtgggtt ttgacttgct tcatccagat atacaattga
     4681 acgatagcca agataaaaga aagcaccatg gagatatagg ccagatagga atagtgcatg
     4741 ttgatgtact ggtttagttt gcccgacaga tggaggtaaa tagtcagttc aaaatagcca
     4801 gctaaaacta aaaatcgaat cataggatta ctccaatcaa gagagaatag actaagacga
     4861 caagagttac aattgttatg aagtgactga taaatcgtgc tttcaagtaa tttttcatca
     4921 tgagaatatt tttgatatcc agcattggac caatgacgag aaaggccaga actggtgcca
     4981 aaccgaaact cgagagaaga gaagcaccta taaaggcatc cgcctcacta cagagcgaaa
     5041 gaagaaaggc taaaatcatc aagagcagga tggcaaaaag aggggtcgca ctgatagagg
     5101 tcagaatccg agtcggaacg tagacctgta ttatagaagc aaagaggcag ccaaatacca
     5161 aataacgccc cgtatcaaaa aattcatcaa tggcctgcac aaagacttga aaaacttttt
     5221 ttgcagaact caagtaagaa aaatcatgct cataacaagc cagacgattt tctttctgaa
     5281 tcggttcttg ccagaaaaat cctagaaaaa ttcctagtat tacagccaca agaatggaac
     5341 ccagagctcg taatagggcg acatggaagg agttgccaaa ggcagaatag gtcgcaaaaa
     5401 gaacaatggg attgataaca ggtgctgtca caagaaaagg aacggccgtg taacttggaa
     5461 cctttttttc cagaaaacga ttgatgatgg ggacgattcc acattcacaa gaagggaaaa
     5521 acataccgac gaaggtccca aaaaagattc tcccccaacg atttcgaggg agaaaatgat
     5581 aaaccttgtc aggtgtgata taaacttcaa tcagccctga gacaatgctt cctatcagaa
     5641 cgaagggaag ggcttcaatg ataatggaga gaaaaatggc tccagtttga agtacactag
     5701 atgggagttg ttgaaaagca gtcatctagt ttttcttttc tgctttggct tttttctctt
     5761 tgtcatcagg gaaagtaact tgtttcaaat cagggagttt agcaaactct tcaaacatct
     5821 tgtccaagtc gtctcgtttt gtaaatttta cagccatagg tgtacctcga ttctaaattc
     5881 tacctctatt atactattat tttgcggaaa agggagtttt ttaatttgtt ttcgatagtt
     5941 gatactcttc gaaaatctct tcaaaccacg tcagcttcgc cttactgtag tacggttact
     6001 gacttcgtca gttctatcca caacctcaaa acagtatttt gagcagccta cggctagctt
     6061 cctagtttgc tttttgattt ttattgagta tgaaaaggat tggagaaagc cttccagctt
     6121 gtggtataat agatttatgg ataaaaaata tgaaaaaatc tctcaggatt tgggagtgac
     6181 gttaaagcaa attgataccg ttctaagttt gacagctgaa ggggcgacta ttccctttat
     6241 cgcgcgttat cgcaaggaca tgactggtag tctggatgag gtggcgatta aggctattat
     6301 tgatttggat aaaagtctga caaatctcaa tgaccgtaag gaagctgtct tagctaagat
     6361 tcaagaacaa ggtaagttga ccaaggaatt ggaagaagct atcttagttg ccgaaaaatt
     6421 agcagacgtt gaagaactct atcttcctta taaggaaaag cgtcgtacca aggcaaccat
     6481 tgcccgtgaa gctggactct ttcctcttgc tcgcttgatt ttgcagaata tagttgactt
     6541 agagaaagaa gctgaaaagt tcgtctgtga aggatttgcg actggcaagg aagccttgac
     6601 cggtgcagtt gatattttgg tcgaagcctt atcggaagat gtgaccttgc gttctatgac
     6661 ttatcaggaa gtgctgagac actctaaact cacttctcaa gccaaggatg aaagtcttga
     6721 tgaaaagcag gtttttcaga tttattatga tttttcagag acagttggaa ctatgcaagg
     6781 ctatcgtacc ttggctctca atcgtgggga gaaacttggt gtcttgaaga tcggttttga
     6841 acatgcgacg gaccgtattc ttgccttctt tgctactcgt ttcaaggtga aaaatgctta
     6901 tattgatgaa gttgttcagc aatccgttaa gaaaaaggtc ttgcctgcta ttgagcgtcg
     6961 tattcggaca gaattaactg agaaagctga agagggagct atccaacttt tttctgacaa
     7021 tctgcgcaat ctcctcttgg ttgctccact gaaagggcgc gtggttcttg ggtttgaccc
     7081 agcctttcgt acaggtgcca agctagctgt cgtggatgca acaggaaaaa tgctgacaac
     7141 tcaggttatt tatcctgtta aaccagcatc agctcgtcaa atcgaagaag ccaagaaaga
     7201 tttagcagat ttaattggtc aatacggtgt agagattatt gccattggaa atggaacggc
     7261 cagtcgtgaa agtgaagctt ttgtagcgga agttctgaaa gatttccctg aagtcagcta
     7321 tgttatcgtt aatgaaagtg gtgcttctgt ctattctgcc agcgaacttg ctcgtcagga
     7381 gtttccagac ttgaccgttg aaaaacgctc tgccatttct atcgcccgtc gtttgcaaga
     7441 tcctcttgcg gaattggtca aaatcgatcc taagtcaatt ggtgtcggtc aataccaaca
     7501 cgatgtcagt cagaagaaac tatctgagag tctggacttt gttgtcgata cagtggttaa
     7561 ccaagttggt gtcaatgtca atacagctag cccagctctt ctttcacacg tagctggact
     7621 caataaaacc atttctgaaa atatcgtcaa ataccgtgag gaagagggaa aaatcacttc
     7681 acgctctcaa atcaagaaag ttcctcgttt gggggccaag gcttttgaac aggctgctgg
     7741 tttcctccgt atccctgaaa gtagcaatat ccttgataat acaggagttc acccagaaaa
     7801 ttacgctgcc gttaaggaac tcttcaaatg cttggacatt aaggatctga atgaagaggc
     7861 ccaaagtaaa ctcaagtcgc tttcagtcaa ggaaatggcg caagagttag accttggtcc
     7921 agaaactctt aaagatatca ttgcagatct tctcaaacca ggtcgagatt tccgtgattc
     7981 ctttgatgct ccagttctcc gtcaagatgt cctagatatc aaggacttag tggttggaca
     8041 aaagctagaa ggagtggtgc gtaatgttgt tgatttcggt gcttttgttg atatcggaat
     8101 tcatgaggac ggtctcatcc atatttccca tatgagtcgc aagtttatca aacaccctag
     8161 tcaagtggtg gcagttggag atttggtgag cgtttgggtt aagaaaattg atactgaacg
     8221 tgaaaaagtt aatctgtctc tcctagctcc aaatgaaact gactgattat gtcaagcagg
     8281 tttcactaga agacttcggc agacctttca tccatcatgt ccagtggaat aggcgtctac
     8341 gttcgacagg tgggcgattt ttccccaaag atgggcatct ggattttaat cccaaggttt
     8401 atcagaaact gggtatggag gtttttagga aaattgtccg acatgaactc tgtcattatc
     8461 acctttattt ccaagggaag ggctatcaac acaaggatcg ggattttaag gaactgttga
     8521 aagcagtgga tggattaagg tttgtaccat ccttgcccaa tagtaactct aaaccactca
     8581 agctttatcg ttgtcaatcc tgccagcaaa ggtatcagcg caagcgtagg attgatacca
     8641 aacgctatcg ctgtggactt tgtcgaggta aattgcttct gataaatcag cctgaggact
     8701 gatgaaagcc gagcctcccc gtgatatact atgtctaacc tagcagaaag aggaaatatc
     8761 atgaacagta aattttataa aatgagacgc aatcgcatga tttcaggagt tctggcaggt
     8821 ctgtcagaca agtggaattt tgatgttacc ctagttcgtt tcttgtttgc catttttaca
     8881 gttgcaaact ttggacttgg cgtgattatc tatatcatcc tagcttctat catgcctacc
     8941 aaggaagaaa tcgaagcaga aatgtacgga acaggcccac gtaaacgcaa agaagcccaa
     9001 gccattgacg acaatgaagg ctggttttgg tgaggttcta cagaagattt ggaataagca
     9061 aaaagcttta aatcaatagt ctaaactgct tgatttaaag cttttttact tttatactca
     9121 ataaaaatca aagtgcaaac taggaagcca gccacaggct gtaatttagt cggcaatgtg
     9181 aagttgacat agtttgcact ttgatttttg aatagtatta ataatatttc gccagcttca
     9241 tccacaaact atagtggatt ggaactagaa taggacacct ctacttctaa aacattgtta
     9301 gaaatcgatt tgactatcct gatcgatttg tcctgttctt atttcatttt attataaaag
     9361 cagtaattta aactcagttt tttaatctat ttttgctgct gagacaatac atttttggaa
     9421 aaatggtgga tgctgataac aactgataac cagcaaataa cataagcagt gccggtaaat
     9481 tctgtaccga taaagtgtgt gtgttcaact aagagctgac cgatgaatgg agagagcaga
     9541 tagagaagtc cgatgagtat atgttctttg tgtttcatta aagcgcacct tctttcctta
     9601 taggttgaac gacttgcaag tgttaaattg aatggtatgt tatctaggta accttactaa
     9661 aatgttagtt cccgcttcct ccttttcaaa gtaagccttt tcacacttat attttacaac
     9721 tttaaaaata ggaaatcaaa tcattttcta agtaattttg cttatatttc acccaatctt
     9781 acaaaaatgt aagattaaag tctcttttgt aaggttaggt tatggcaagc gatctttttt
     9841 tgatgtaaac tagactcata aagaacaaag gagtaacatc atgaaacaaa tcttacataa
     9901 gaaaactaga aaaccaagtc acaaagaaat tgagcgcgtt cagctgggat gcactatgat
     9961 gcaagctaca tttcatttga tgggatatta agaaaggaga ttctcatgac acttttagat
    10021 gtaaaacacg ttcaaaaaat ttataaaaca cgttttcagg gcaaccaagt agaagccctc
    10081 aaggatattc actttaccgt cgaaaagggt gactacgttg ccatcatggg tgagtctggt
    10141 tctggtaaat caactcttct caatattcta gctatgctgg ataaaccaag tcgtggtcag
    10201 gtttacttga atggaactga caccgcaacc attaaaaatt cacaggcctc tagcttccgt
    10261 cgtgaaaagt tgggctttgt cttccaagac tttaacttgc tagatactct atctgtaaag
    10321 gacaatatct tgcttccgct tgtcttgtca agaagaccta ttacagagat gatgaagaaa
    10381 ttggtggtga cagctgagaa tctgggaata aaccaattac aagagaagta cccttacgag
    10441 atttctggtg gccagaaaca gcgtgtagca gtagcacgcg ccatcatcac tgaacctgaa
    10501 attctccttg cggacgaacc gacaggagct cttgactcca agtcatctgc agccttactt
    10561 gatgtctttg atgaaatcaa tgagcgcggc caaaccattc tcatggtaac ccactcaaca
    10621 gcagcagcta gcagagctaa acgtgtactc tttatcaaag acggcattct ttacaatcaa
    10681 atctaccgtg gagagaagac agaacgtcag atgttccaag aaatctctga taccttgact
    10741 gtcatggcaa gcgaggtgaa ttagtatgtt tcgattaacc aataagttag cggtatcgaa
    10801 cttgattaaa aaccgcaaac tctactatcc ttttgcgctg gctgttctct tggcagtcac
    10861 tgtcacctat ctcttttact ctctaacctt caatcctaag attgcggaaa tccgtggagg
    10921 aacaaccatt caggctacac ttggatttgg tatgtttgtc gtcacccttg cgtcagccat
    10981 tatcgttctc tatgccaata gttttgtcat gaagaaccgt tccaaggaac taggaattta
    11041 tggcatgttg ggcttggaga agcgtcatct tatcagtatg acctttaagg agttagtggt
    11101 atttgggatt ctaactgttg gagcgggtat cggtattgga gccttgtttg acaagttaat
    11161 tttcgctttc ctgctcaaac taatgaaatt gaaggttgag ctggttgcta ccttccagac
    11221 gaaagttgtc attacagtgc ttgttgtctt cggtttgatt ttcctaggcc tcatgttcct
    11281 gaatgccctt cgaatcgccc gtatgaatgc cctccagctc tctcgtgaga aagctagtgg
    11341 agagaaaaaa ggtcgcttcc ttcctctcca aaccattctt ggttccataa gtttaggaat
    11401 tggctattat cttgccctta cggtaaaaga tcctcttaca gccttaacaa ccttcttcat
    11461 agctgtttta ctggttatct ttgggactta tctcttgttt aatgcaggga ttaccgtttt
    11521 cctccaaatc ttaaagaaaa ataagaaata ctattaccaa ccaaataacc tcatatctgt
    11581 ttctaacttg attttccgta tgaagaaaaa tgcagttgga ctagctacca tcgctatctt
    11641 gtcaacaatg gttttggtaa ccatgtcagc agcgacaagc attttcaatt cctcagaaag
    11701 ctttaaaaaa gttctaaatc ctcatgattt tggggtttca gggcaaaatg ttgaaaaaga
    11761 agacttggac aaactcttga gccagtttgc aagtgacaaa ggttataaga ttaaagaaaa
    11821 agaagtattt cgttacactt actttgctgt tgcgaatcaa gaaggaacca agttaactat
    11881 ttttgaaaaa ggacaaaacc gtgtccaacc aaaaacagtt ttcatggtat ttgaccaaaa
    11941 agattatgaa aatatgactg gtcaaaaact gtctctatca ggaaatgagg tcggactctt
    12001 tgcaaagaat gagggagtta aagaacagaa agctctaact ctaaatgatc atcaattttc
    12061 tgtaaaagaa gaatttacta aagattttat tgtcaaccat gttccaaatc agtttaatat
    12121 tttgactgct gattacaatt accttgttgt acctgattta caagcctttt tggatcaatt
    12181 cccagattcg gctatctata atcagtttta cggtggtatg aatgtaaatg ccagtgaagc
    12241 agaacaactc aaggtcgctg aggagtatga aaaatactta caaaagttta atgctcaatt
    12301 aaacactgaa ggtaactatg tgtatggtag cactctagca gatgctagtg ctcagatgag
    12361 tgccctcttt ggtggtgtct tctttatcgg tattttctta tccattatct ttatggtcgg
    12421 aaccgttctg gtcatctact acaaacaaat ttctgaagga tatgaagacc gtgagcgctt
    12481 tattatcttg cagaaagtcg gtttagatca aaagcaaatc aagcaaacca tcaacaaaca
    12541 ggttttaact gtattcttcc ttcctttgct ctttgccttc ctacatctag cctttgccta
    12601 ccatatgctt agtctgattt taaaagtgat tggtgtactg gatacgacta tgatgttgat
    12661 tgtgaccttg tctatctgcg ctatcttcct catcgcctat gtgctgattt tcatgattac
    12721 ttcaagaagt tatcgtaaga ttgtccaaat gtaaaaaaag atacctcgac ttcaaaatcg
    12781 aggtatttct tgttttctaa atgctgaaaa gttgtccgag caggaaggta actcccatag
    12841 ttaagagacc aatagcaagg ttccgaatca tagctgtttt ggttggggct tttccaagtc
    12901 tagcacttgt gtagccagtg agaagaaggg ctacaccgac gataaggacg gtagcaggga
    12961 tgcggtaatc acttggaaaa atggtcactg acagcattgg aggcaaactt ctaaggaaaa
    13021 aggcaacgaa gctagaaatg gcagcgtgcc aaggattggt aaattcttca tactcaatcc
    13081 catatttttc ctctaccaga gccttgagtg gatttttaag aaagatctta ttagtcaaga
    13141 gttgggcaga agttttgaat tctccatttt ggatataaga agcatagagg gattttttgg
    13201 ctagttccct atcttggtct agcaagagtt tttctcgcga aacggcagct tcctcggtat
    13261 cttttggagt tgaaacggat acatattctc caccagcaat ggaaataatt ccatcgttag
    13321 catcaagaac acccgcacgc aggatattta aacgacctgc aaaatttgaa tcaatttcgt
    13381 gatttgtttc tgacgctaaa tttcaagttc aagttagcca tccagaagtc ttctctgggt
    13441 gacttgtagt ccaagcattt tttaggatag ttgttaatcc acttttcgat gaatgcgact
    13501 tctttgggag tcattttctt ggttccctta ggtaaccatc tacgaatgag cctgttgtga
    13561 ttctcattag ttcccctttc ccaagaggca taggggtgcg cataatagat gtgctcctca
    13621 gaaaatacat caaacaagcg attgaattcc gttccattat ctgccgtgat ggaaagaatc
    13681 ttgtgttgtt ttaagatgag ttttagagcc tgattgacca cctcagcact tttatttgga
    13741 atcaatcgga tgatctgatg tctactcttt cgatccgtca agacaagcaa gcagtagttt
    13801 ttcgctctcg taagtagaac cgtatcaatc tcataatgcc cattctccaa gcgaagattg
    13861 atagcttcag accgctgttc gatggattga ccagc
//
LOCUS       DAVHIZ010000048        13576 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.050, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000048 DAVHIZ010000000
VERSION     DAVHIZ010000048.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 13576)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13576)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13576
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.050"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            4..321
                     /locus_tag="VVO18_001612"
     CDS             4..321
                     /locus_tag="VVO18_001612"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001828804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586728.1"
                     /translation="MIILLPCFYFFSWIDKDNRESKFFPIFYYFYWIYITLYSLFSLA
                     WTVFSVLFFNIVLRNLTDIKLWGIWLLLLLIAFASDWLDYICFKKMLDLRRELGKSKG
                     VRH"
     gene            506..1297
                     /locus_tag="VVO18_001613"
     CDS             506..1297
                     /locus_tag="VVO18_001613"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398883.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586729.1"
                     /translation="MKIPLLTLARHKFVYVLLTLLFLALVYRDVLMTYFFFDIHAPDL
                     AKFDGQAIKNDLLKSALDFRILQFNLGFYQSFIIPIIIVLLGFQYIELKNKVLRLSIG
                     REVSYQGLKRKLTLQVASIPCLIYLVTVLIIAIVTYFFGTFSPLGWNSLFSDGSSLQR
                     LLDGEITSYLFFTCVLLIGIFINAVYFFKIVDYLGNVTRSAITYLMFLWLGSMLLYSA
                     LPYYMVPMTSLMQASYGDVSLMKLFTPYILYIVPYMVLEKYEDNV"
     gene            1290..1931
                     /locus_tag="VVO18_001614"
     CDS             1290..1931
                     /locus_tag="VVO18_001614"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475766.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586730.1"
                     /translation="MFKNFNNILLKRKIVLLLRIVLMMILINHLLSTAVQKQDAVIFF
                     KRELISIFSYNDYSEVNLEIPKLLLNLSLFMVGWLSVILLESDLADHYHHLIRYQSSS
                     FFDYTRKRLVVISKFFTQDLLVWFLGLLPLGIHFKTVALFFLFAQLMMLYLLLSYLIA
                     LISAGAGFSFFLYFLAFVGQEWMMDHIVTVYLLLLSLLVMLIVSRLEEKFKKG"
     gene            1935..2585
                     /locus_tag="VVO18_001615"
     CDS             1935..2585
                     /locus_tag="VVO18_001615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000763094.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5586731.1"
                     /translation="MKLEIINGQKIYGKRPILNQLNLVFQSGKIYGLKGDNGSGKTVL
                     LKVLAGYIKLDKGKVLQDGKVYGIKNHYIQDAGILIEKVEFLSHLSLRENLELLRYFS
                     SKVTEKRIAYWIQYYDLQEFEDVEYRHLSLGTKQKMALIQAFISSPSILFLDEPMNAL
                     DEKSVRLTKQVILSYLKKENGLVILTSHISEDISDLCTDVLVVENGHIQYVKDIQS"
     gene            2596..2883
                     /locus_tag="VVO18_001616"
     CDS             2596..2883
                     /locus_tag="VVO18_001616"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000940707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586732.1"
                     /translation="MAHLKSFITRYSKVYIGLVLLIWLSFFFIPWDRAILGVRIDIFI
                     IQKVLLVFGILSILMALLSKKVSLFVFGLICCLSLWINLFITFAILPIFGN"
     gene            3029..5542
                     /gene="secA"
                     /locus_tag="VVO18_001617"
     CDS             3029..5542
                     /gene="secA"
                     /locus_tag="VVO18_001617"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecA"
                     /protein_id="HEU5586733.1"
                     /translation="MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAK
                     TVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRT
                     GEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKS
                     PMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEAR
                     TPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLE
                     NLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGL
                     HQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIP
                     IPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKL
                     VAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCV
                     IGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSE
                     EAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAQRYDVITADRDL
                     APEIQSMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAI
                     KEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLR
                     GYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRN
                     IAAHQASMPEDLDLSQIGRNELCPCGSGKKFKNCHGKRK"
     gene            5623..6654
                     /locus_tag="VVO18_001618"
     CDS             5623..6654
                     /locus_tag="VVO18_001618"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000232189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEU5586734.1"
                     /translation="MVFTAKSSKINIEEVRALSKLEGQALERKSQRDQELEAIIRGED
                     QRILLVIGPCSSDNEEAVLEYAKRLAVLQEEVADRIFMVMRVYTAKPRTNGDGYKGLI
                     HQPNATEAPSLINGIKAVRHLHYRVITETGMTTADEMLYPENLPLVDDLISYMAVGAR
                     SVEDQQHRFVASGAGFSTGFKNPTSGNLNVMFNGIYAAQNKQSFLFLGKEVETTGNPL
                     SHAILRGALNEYGKNIPNYYYDNLIDTIAQYEKMGLENPFIIIDTNHDNSGKQYIEQI
                     RIVRQTLINRAWNEKIKQFVRGFMIESYLEDGRQNEPEVFGKSITDPCLGWDNTEALV
                     REIYKTLGE"
     gene            6656..7687
                     /locus_tag="VVO18_001619"
     CDS             6656..7687
                     /locus_tag="VVO18_001619"
                     /EC_number="2.5.1.54"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="HEU5586735.1"
                     /translation="MAFIEKGQEIDMEVIKAETQLSAEALRLKESRDRELADIISGED
                     DRILLVIGPCSSDNEEAVLEYARRLSALQKKVADKIFMVMRVYTAKPRTNGDGYKGLV
                     HQPDTSKAPSLINGLQAVRQLHYRVITETGLTTADEMLYPSNLILVDDLVSYHAVGAR
                     SVEDQEHRFVASGIDAPVGMKNPTSGNLGVMFNAIYAAQNKQTFLYHGQEVETSGNPL
                     AHVILRGAVNEYGNYMPNYYYENLLQAIERYETMGLENPFILIDTNHDNSGKQYMEQI
                     RIVRQTLQNRDWNEKIKKTVRGFMIESYLADGRQNQPEIFGCSITDPCLGWENTEALV
                     EEIYVTLTK"
     gene            7726..8094
                     /locus_tag="VVO18_001620"
     CDS             7726..8094
                     /locus_tag="VVO18_001620"
                     /EC_number="2.7.8.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000061844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="holo-ACP synthase"
                     /protein_id="HEU5586736.1"
                     /translation="MRMIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLK
                     GRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLS
                     ISHTDQFVTASVILEENHES"
     gene            8084..9187
                     /locus_tag="VVO18_001621"
     CDS             8084..9187
                     /locus_tag="VVO18_001621"
                     /EC_number="5.1.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000648075.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alanine racemase"
                     /protein_id="HEU5586737.1"
                     /translation="MKASPHRPTKVLIHLGAIRQNIQQMGAHIPQGTLKWAVVKANAY
                     GHGAVAVAKAIQDDVDGFCVSNIDEAIELRQAGLSKPILILGVSEIEAVALAKEYDFT
                     LTVAGLEWIQALLDKEVDLTGLTVHLKIDSGMGRIGFREASEVEQAQDLLQQHGVRVE
                     GIFTHFATADEESDDYFNAQLERFKTILASMKEVPELVHASNSATTLWHVETIFNAVR
                     MGDAMYGLNPSGAVLDLPYDLIPALTLESALVHVKTVPAGACMGYGATYQADSEQVIA
                     TVPIGYADGWTRDMQNFSVLVDGQACPIVGRVSMDQITIRLPKLYPLGTKVTLIGSNG
                     DKEITATQVATYRVTINYEVVCLLSDRIPREYY"
     gene            9206..11221
                     /gene="recG"
                     /locus_tag="VVO18_001622"
     CDS             9206..11221
                     /gene="recG"
                     /locus_tag="VVO18_001622"
                     /EC_number="3.6.4.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001048793.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent DNA helicase RecG"
                     /protein_id="HEU5586738.1"
                     /translation="MNLHQPLHVLPGVGPKSAEKYAKLGIENLQDLLLYFPFRYEDFK
                     TKQVLELEDGEKAVLSGQVVTPASVQYYGFKRNRLRFSLKQGEVVFAVNFFNQPYLAD
                     KIELGATLAVFGKWDRAKASLTGMKVLAQVEDDLQPVYRLAQGISQASLVKVIKTAFD
                     QGLDLLIEENLPQSLLDKYKLMSRCQAVRAMHFPKDLAEYKQALRRIKFEELFYFQMQ
                     LQTLKSENRVQGSGLVLDWSQEKVTAVKASLPFALTQAQEKSLQEILTDMKSDHHMNR
                     LLQGDVGSGKTVVAGLAMFAAVTAGYQAALMVPTEILAEQHFESLQNLFPNLKLALLT
                     GSLKAAEKREVLETIAKGEADLIIGTHALIQDGVEYARLGLIIIDEQHRFGVGQRRIL
                     REKGDNPDVLMMTATPIPRTLAITAFGDMDVSIIDQMPAGRKPIVTRWIKHEQLPQVL
                     TWLEGEIQKGSQVYVISPLIEESEALDLKNAIALSEELTTHFAGKTEVALLHGRMKSD
                     EKDQIMQDFKERKTDILVSTTVIEVGVNVPNATVMIIMDADRFGLSQLHQLRGRVGRG
                     DKQSYAVLVANPKTDSGKDRMRIMTETTNGFVLAEEDLKMRGSGEIFGTRQSGLPEFQ
                     VADIIEDFPILEEARKVASYISSIEAWQEDPEWRMIALHLEKKEHLD"
     gene            11537..12518
                     /locus_tag="VVO18_001623"
                     /pseudo
     CDS             11537..12518
                     /locus_tag="VVO18_001623"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844805.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="acetylxylan esterase"
     gene            complement(12840..13376)
                     /locus_tag="VVO18_001624"
     CDS             complement(12840..13376)
                     /locus_tag="VVO18_001624"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586739.1"
                     /translation="MADRTDEVSSKHRFEVADRTDEVSSKHRFEVADRTDEVSSKHRF
                     EVADRTDEVSSKHCFEVADRTDEVSSKHCFEVVDRTDEVSSKHCFEVADRTDEVSSKH
                     CFEVVDRTDEVSSKHCFEVVDRTDEVSSKHCFEVADRTDEVSSKHCFEVVDRTDEVSN
                     HTYGKAKLTWFKEIFEKY"
BASE COUNT         3889 a         2577 c         3032 g         4078 t
ORIGIN      
        1 aaaatgataa tcttattacc ctgtttttac tttttcagct ggattgacaa ggataataga
       61 gaaagtaaat ttttcccaat tttttactat ttttactgga tttacatcac cctctattct
      121 ctttttagcc ttgcttggac agttttttca gttctgtttt tcaatatcgt cttgagaaat
      181 ttgacagata tcaagttatg gggtatttgg ctattattac tacttatcgc ttttgctagt
      241 gactggttag actatatctg tttcaaaaaa atgcttgact tgagacggga actagggaag
      301 tctaaaggcg taaggcattg atttatactc ttcgaaaatc tcttcaaacc acgtcaacgt
      361 cgccttggat tatatatgta actgacttcg tcagtcttat ctacaacctc aaagcagtgc
      421 tttgagcaac ttgcggctag tttcctagtt tgctctttga ttttcattga gtattatatt
      481 actttctatt tgtaggaggt tgcttatgaa gattcctctc ttaactttgg caaggcataa
      541 atttgtttat gtcttgctta ctttgctttt tcttgctttg gtttatcgtg atgttttgat
      601 gacttatttc ttttttgata ttcatgcgcc cgatctagct aaattcgatg gacaagcaat
      661 taaaaatgac ttattaaaat cagcattaga ttttcgtatt ctccagttca atctaggttt
      721 ttatcaatca tttattattc caatcatcat tgttttgcta ggttttcaat atattgagct
      781 gaaaaataaa gttttacgat tgagtattgg aagagaagtg agttatcaag ggttaaaaag
      841 aaagttgact ttgcaagttg caagtatccc ttgtttgata tatttagtga ctgtgctgat
      901 aattgcaatt gtaacctatt tctttgggac tttttctcct cttggatgga attctctatt
      961 ttctgatggg agtagtttac aaaggctcct agatggagag ataacaagct atttgttctt
     1021 tacttgtgtc ctactaatcg gtattttcat caatgcagtc tattttttta aaatagttga
     1081 ttatttagga aatgtgactc gttcggcaat cacctatttg atgtttcttt ggcttggttc
     1141 tatgctgctc tatagtgcct tgccttacta tatggttcct atgacgagtt tgatgcaagc
     1201 tagctatggg gatgtaagtt tgatgaaact ctttactcct tatatccttt atattgtccc
     1261 ttacatggtg cttgaaaaat atgaagataa tgtttaagaa ttttaacaat attttgctaa
     1321 agagaaagat tgttttacta cttcgtatag ttctgatgat gattttgata aaccatctat
     1381 tgtcaacagc ggttcaaaag caggatgctg ttatcttttt caagagagaa ttgatttcaa
     1441 ttttttccta taatgactat tctgaagtga atttagaaat ccccaaactc ttgttaaacc
     1501 tttcgctttt catggtagga tggctctctg tcattttact tgaaagtgat ttggcagacc
     1561 attaccatca cttgattcgc tatcaatcaa gctccttttt cgattataca aggaaacgat
     1621 tggttgtcat ttctaaattt tttactcaag atttacttgt ctggttcctt ggtttacttc
     1681 cgctaggaat tcatttcaaa acagtcgcac ttttcttttt atttgctcag ttaatgatgt
     1741 tgtacttact actgtcttat ctgatagcac tgattagtgc gggcgctggt ttttcctttt
     1801 ttctctattt tttagcattt gtgggacaag aatggatgat ggatcatatt gtaacagtgt
     1861 atttactact cttaagctta ttagttatgt tgattgttag tcgcttggaa gagaaattta
     1921 agaaaggata aacgatgaaa cttgaaatta taaatggaca gaaaatttat gggaaaagac
     1981 ctattttaaa tcagttgaat ttggtgtttc aatcaggaaa aatttatgga cttaaaggtg
     2041 ataatggatc tggcaagacg gttcttttaa aggtacttgc tggttatatt aagcttgaca
     2101 aaggaaaagt tcttcaagat ggtaaagttt acgggataaa aaatcattat attcaggatg
     2161 caggaatttt aattgaaaaa gtcgagtttt tatctcattt atccctgaga gaaaatttgg
     2221 aactgttaag gtatttttca tctaaagtta cggaaaaaag aattgcctat tggattcaat
     2281 actatgattt acaggaattt gaagacgttg aataccggca tttatccttg ggaacaaagc
     2341 aaaaaatggc cttgattcaa gcctttattt cctctccttc tatactcttt ctcgatgaac
     2401 ctatgaatgc tttggatgag aagagtgtga ggttaaccaa acaggtcatt ttatcttacc
     2461 tgaaaaaaga aaatggtctg gttatcctga cgtcgcacat atcagaagat atttcagacc
     2521 tttgtacaga tgtattagtt gtcgaaaatg gacatataca atatgtaaag gatatacaat
     2581 cctaggagat ggcttatggc acatctaaaa tcatttatta cacgctattc caaggtttat
     2641 attggtttag ttctgctgat ctggctgtct ttcttcttta tcccttggga tagagcgatt
     2701 ctgggggtaa ggattgacat cttcatcata cagaaagtct tgctagtttt tggaattctg
     2761 tccattttga tggccttgct gtccaagaaa gtcagtctct ttgtttttgg actgatttgc
     2821 tgtctttctc tttggattaa cttatttatc acatttgcca ttttgccaat ttttggcaat
     2881 taaacagtca taaaagtcgg agaggttagc ttgaaaacta acctcttttt ccttttcaaa
     2941 atggggattc ttccttgaaa ataatcagta attgtgctaa aattaaagga acattctaaa
     3001 atattcggaa tttaaagtaa ggaaaaacat ggctaatatt ttaaaaacaa ttatcgaaaa
     3061 tgataaagga gaaatccgtc gtctggaaaa gatggctgac aaggttttca aatacgaaga
     3121 ccaaatggct gctttgactg acgaccaact aaaagcaaaa acagttgaat ttaaggaacg
     3181 ttatcaaaat ggagaatcac tggattcatt gctttacgaa gcatttgcgg ttgtccgtga
     3241 aggtgccaaa cgtgtcctag gtctcttccc ttataaggtt caggtcatgg gggggattgt
     3301 tcttcaccat ggtgacgtgc cagagatgcg tacaggggaa gggaaaacct tgactgcgac
     3361 catgccggta tacctcaatg ccctttcagg taaaggggtt cacgtagtta cggttaatga
     3421 atacctgtca gaacgtgacg cgactgagat gggtgaattg tactcttggc ttggtttgtc
     3481 agtagggatt aacttggcta ccaaatctcc aatggagaaa aaagaagcct atgagtgtga
     3541 tattacttac tcaactaact cagaaatcgg atttgactac cttcgtgaca atatggtcgt
     3601 tcgcgctgaa aacatggtac aacgtccgct taactatgcc ttggtcgatg aggttgactc
     3661 tatcttgatt gacgaggctc gtacaccttt gattgtatca ggtgccaatg cggttgaaac
     3721 cagtcagttg tatcacatgg cagaccacta tgtaaaatct ttgaacaaag atgactacat
     3781 catcgatgtg cagtctaaga ctattggttt gtctgattca gggattgaca gggctgaaag
     3841 ctacttcaaa cttgaaaacc tctatgacat cgaaaacgtg gctttgaccc actttatcga
     3901 taacgccctt cgtgccaact acatcatgct tctcgatatt gactatgtgg tgagcgaaga
     3961 gcaagaaatc ttgattgtcg accaatttac aggtcgtacc atggaaggtc gtcgttattc
     4021 tgatggattg caccaagcta ttgaagccaa agaaggtgtg ccaatccagg atgaaaccaa
     4081 gacatctgcc tcaatcacgt accaaaacct tttccgtatg tacaaaaaat tgtctggtat
     4141 gacgggtaca ggtaagactg aggaagaaga atttcgtgaa atctacaaca ttcgtgttat
     4201 tccaatccca acaaaccgtc ctgttcaacg tattgaccac tcagaccttc tttatgcaag
     4261 tatcgaatct aagtttaaag cggttgtcga agacgttaag gctcgttacc aaaagggtca
     4321 acctgtcttg gttggtacag tagcggttga aactagtgac tacatttcta agaaattggt
     4381 cgcagctggt gttcctcacg aagtcttgaa tgccaaaaac cactatagag aagcccaaat
     4441 catcatgaat gctggtcaac gtggtgccgt taccatcgca accaacatgg cgggtcgtgg
     4501 taccgacatc aagcttggtg aaggtgttcg tgaacttgga ggactttgtg ttattggtac
     4561 agaacgtcat gaaagtcgtc gtatcgataa ccagcttcgt ggacgttcag gtcgtcaagg
     4621 agatccaggt gagtcacaat tctacctatc tcttgaagat gatttgatga aacgttttgg
     4681 ttctgaacgc ttgaagggaa tctttgaacg cttgaacatg tctgaagagg cgattgagtc
     4741 tcgcatgttg acgcgtcagg ttgaagcagc tcagaaacgt gtcgaaggaa ataactacga
     4801 tacccgtaaa caagtccttc aatacgatga tgtcatgcgt gaacaacgtg agattatcta
     4861 tgctcaacgt tacgatgtca tcactgcaga tcgtgacttg gcacctgaaa ttcagtctat
     4921 gattaagcgc acgattgaac gtgtcgttga tggtcatgcg cgtgccaaac aagatgaaaa
     4981 actagaggca attttgaact ttgctaagta caacttgctt cctgaagatt ctattacgat
     5041 ggaagacttg tcaggcttgt ctgataaggc catcaaggaa gagcttttcc aacgtgcctt
     5101 gaaggtttac gatagtcagg tttcaaaact acgcgatgaa gaagcagtta aagaattcca
     5161 aaaagttttg attctacgag tggtggataa caagtggaca gatcatatcg atgcccttga
     5221 tcaattgcgt aacgcggttg gacttcgtgg ctatgctcag aacaaccctg ttgttgagta
     5281 tcaggcagaa ggtttccgta tgtttaatga tatgattggt tcgattgagt ttgatgtgac
     5341 acgcttgatg atgaaagcac aaattcatga acaagaaaga ccacaggcag aacgtcatat
     5401 cagtacaaca gcgactcgca atatcgctgc tcaccaagca agtatgccag aagatttgga
     5461 tttgagccag attggacgca atgaactttg cccatgtggt tctggtaaga aatttaaaaa
     5521 ctgtcacggt aaaagaaaat aaaatgagat agtttagagg cggatatctt gtgaaaagta
     5581 aatttttact gggtatccgt ttgctttata aggagatgag ttatggtatt tacagcaaaa
     5641 agctctaaaa taaatataga agaagttcgt gccttgtcaa aattagaagg tcaggctttg
     5701 gagaggaaat cacagcgaga tcaagagcta gaagccatta tacgtggaga agaccagcga
     5761 attctcttgg taatcgggcc atgctcatct gacaacgaag aagctgtcct tgaatacgct
     5821 aagcgtttgg cagtcctaca agaagaagtg gcagatcgta tctttatggt tatgcgtgtt
     5881 tatactgcca aaccccgtac caacggagat ggctataagg gcttgattca ccagcctaac
     5941 gcgacagaag cgcctagtct tatcaatgga atcaaagccg ttcgccatct tcactatcgt
     6001 gtcatcacag aaacagggat gacaactgct gatgaaatgc tttatcctga aaaccttccg
     6061 cttgtagatg atttgatttc ttacatggca gttggtgccc gttcagttga agaccagcaa
     6121 caccgctttg tggcaagtgg ggcaggattt tctactggtt ttaaaaatcc aacctctgga
     6181 aatctcaatg tcatgtttaa tgggatttat gctgctcaaa acaaacaaag tttccttttc
     6241 ttaggaaaag aagtagaaac aactgggaac ccgctttcac acgctattct tcgtggtgct
     6301 cttaatgagt atggaaaaaa tattcccaac tactattatg acaatttaat tgataccatt
     6361 gcccagtatg agaaaatggg cttggaaaat ccttttatca tcattgatac caatcatgac
     6421 aattctggta agcagtatat tgaacagatc cgaattgtcc gccagacctt gattaaccgt
     6481 gcttggaatg aaaaaattaa gcagttcgtt cgtggtttta tgattgagtc ttatctggaa
     6541 gatggtcgac aaaatgagcc agaagtattt ggtaagtcta tcacagaccc ttgcctgggt
     6601 tgggataaca cagaagctct tgtcagagaa atttacaaaa cgttaggaga ataagatggc
     6661 atttattgaa aaaggtcaag aaatcgatat ggaagtcatt aaggctgaaa cccaattgtc
     6721 tgcggaagcc ttgagactca aggaaagccg tgacagggaa ttggcagata ttatttcagg
     6781 ggaagatgac cgtattctct tggtgattgg tccttgctct tctgataatg aagaagcggt
     6841 cttggaatat gctcgccgtt tatccgcctt gcaaaagaag gtagcggaca agattttcat
     6901 ggtcatgcgc gtgtatactg ctaagcctcg taccaatgga gacggctata aaggattagt
     6961 tcaccagcca gatacttcta aggctccaag cctgattaat ggcttgcagg ctgtgcgcca
     7021 gttgcactac cgcgtgatta cagagactgg tttgacaacg gcagatgaga tgctttatcc
     7081 gtcaaatctg atcttggtgg atgacttggt cagctaccat gccgttggag ctcgttctgt
     7141 ggaagaccaa gagcaccgct ttgtggcttc tgggattgat gcaccagtag ggatgaaaaa
     7201 tccaacctca ggaaatttgg gtgttatgtt taacgccatc tatgctgctc aaaacaagca
     7261 aaccttcctt tatcatgggc aggaagttga gacatcaggt aatcctttgg cccatgttat
     7321 cctccgtgga gcagtcaacg agtatggcaa ttatatgccg aattactact atgaaaacct
     7381 actccaagcc attgaacgct atgaaaccat gggacttgaa aatcctttta tcctcattga
     7441 caccaaccat gataactcag gcaagcaata tatggagcag attcgaattg ttcgccagac
     7501 cttgcagaat cgtgattgga atgagaaaat taaaaagacg gttcgaggat ttatgattga
     7561 atcttaccta gcagatggtc gtcaaaacca accagagatc tttggttgct ctattactga
     7621 cccttgccta ggttgggaaa atacagaggc cttggtagaa gagatttatg ttaccttgac
     7681 aaaataagtg aaaaggatgg agttggggaa tctcaactcc ttttgatgag aatgatagtt
     7741 ggacacggaa ttgacatcga agaattggct tcgatagaaa gcgcagttac acgacatgaa
     7801 ggatttgcta agcgtgtact gaccgctcag gaaatggagc gcttcaccag tctcaaagga
     7861 cgcaggcaaa tagaatattt agctggtcgc tggtcggcta aggaggcctt ttccaaggct
     7921 atgggaacgg gcattagcaa gctcggtttt caggatttgg aagtcttgaa caatgaacgt
     7981 ggggcgcctt attttagtca ggcaccattt tcaggaaaga tttggctgtc tatcagccac
     8041 accgatcagt ttgtgacagc cagtgtcatt ttggaggaaa atcatgaaag ctagtccaca
     8101 tagaccaacc aaggttctga ttcatctggg agctattcga caaaatattc agcaaatggg
     8161 ggctcatatc cctcaaggaa cgctcaagtg ggctgtggtc aaggccaatg cttatggcca
     8221 tggagctgtt gccgttgcca aggcaattca agatgatgtt gatggctttt gcgtttccaa
     8281 tatcgatgaa gccattgaac tcagacaagc tggactcagc aagccaatcc tcattttagg
     8341 agtttctgaa atcgaagctg ttgctctagc taaagaatat gacttcacct tgacagtggc
     8401 tggactggag tggattcaag cactcttaga taaggaagtg gacctaactg gattgacagt
     8461 ccacctcaag attgattcag ggatgggacg gattggtttt agagaggcca gtgaggttga
     8521 gcaggctcaa gatttgctac aacaacacgg tgttcgtgtt gaaggaatct ttacccactt
     8581 tgctactgct gatgaggaat cagatgacta ttttaatgcc cagttagaac ggtttaaaac
     8641 tattttagct agtatgaagg aagttccaga gctggttcat gctagcaatt ctgcaacgac
     8701 tctttggcat gtagagacta ttttcaatgc ggttcgtatg ggagatgcca tgtatggcct
     8761 caatccaagt ggagcggtct tggatttgcc ttatgatttg ataccggcct tgaccttgga
     8821 gtctgctctg gttcatgtca agacagttcc agctggagct tgcatgggct atggagcaac
     8881 ttatcaagcg gatagcgagc aagtcatcgc gaccgtgcca atcgggtatg cagatggatg
     8941 gacaagagac atgcaaaatt tctctgtctt ggtagatggc caagcttgcc caattgtcgg
     9001 cagggtttcg atggaccaaa tcactattcg attgcctaag ctttatccgc taggaaccaa
     9061 ggtaaccttg attggctcca atggggataa ggaaatcact gcaactcagg tagcgaccta
     9121 ccgcgtaacc attaactatg aggtggtttg cctcctcagc gaccgtattc cgagagaata
     9181 ttattagaaa agaaaggagt ggagcatgaa tctacatcaa cccttgcatg tcttgcctgg
     9241 tgtgggacca aagtcagcag aaaaatacgc caaactagga attgaaaact tgcaagatct
     9301 cttgctctac tttcctttcc gttatgaaga cttcaaaacc aagcaggtgc tggagctgga
     9361 agacggtgag aaggcagttc tttctggtca ggtagtgact cctgctagtg tccagtatta
     9421 tggtttcaag cgcaatcgcc tgcgttttag tctcaagcag ggagaggtcg tttttgcggt
     9481 gaatttcttt aaccagccct atctggctga taaaatagag ttgggagcaa cccttgctgt
     9541 ctttggaaaa tgggaccgcg ctaaggctag tctgactggg atgaaggttc tggctcaggt
     9601 agaagatgac ctccagcctg tctatcgtct ggctcaggga atcagtcagg ccagtctggt
     9661 caaggtcatc aagacggctt ttgatcaggg actggacctc ttgatagaag aaaatctgcc
     9721 ccagtcttta ctagacaaat acaaactcat gtcccgttgt caggcagtcc gagctatgca
     9781 ttttccaaag gatttggcag aatacaagca ggctcttcgc cgtatcaagt ttgaggaact
     9841 cttttatttc caaatgcagc tgcagacgct caagtctgaa aatagagttc agggaagtgg
     9901 tctggttctg gattggtctc aggaaaaagt gacagcagtt aaagcaagtc ttccttttgc
     9961 cctgacccaa gctcaggaaa agagtttgca ggaaatttta actgatatga agtccgacca
    10021 ccacatgaat cgtctcctac aaggagatgt ggggagcgga aaaacggtag tcgctggctt
    10081 ggccatgttt gcggcagtga cagcaggtta tcaggctgcc ctaatggtac caacagaaat
    10141 cctcgcagag caacactttg agagtttaca gaaccttttt cccaatttga aactggctct
    10201 cttgacaggt tccttgaaag ctgcagaaaa gagagaagtc ttggagacca ttgccaaggg
    10261 tgaggctgat ttgattatag gaactcacgc tctgatacaa gatggggtgg agtatgctcg
    10321 tcttggtttg attattatcg atgagcagca ccgttttggt gtagggcaaa ggcgtatttt
    10381 acgggaaaaa ggcgacaatc cagatgtcct catgatgacg gcgactccca ttccacggac
    10441 gcttgccatc acagcctttg gagatatgga tgtttccatt atcgaccaga tgccagcagg
    10501 tcggaagcct attgtgacgc gctggatcaa acatgagcaa ctacctcagg tcttgacttg
    10561 gttagagggg gaaattcaaa aaggttccca agtctatgtc atctctcctt tgattgaaga
    10621 atcagaagct ctagatttga aaaatgccat tgccttatca gaggagttga cgactcattt
    10681 tgcaggcaag acagaggtgg ctcttctaca tggtaggatg aagagtgacg aaaaagacca
    10741 gatcatgcag gatttcaagg agagaaagac ggatattctg gtttcgacga cggttattga
    10801 ggttggggtc aacgttccca atgcgactgt catgattatc atggatgccg atcgcttcgg
    10861 tctcagtcaa cttcaccagc ttagaggtcg tgtcggtcgg ggggacaagc agtcctacgc
    10921 tgttctcgtt gccaatccca agacggattc tgggaaagac cgcatgcgta tcatgacaga
    10981 aacgaccaat ggatttgtcc ttgcggagga agatttgaaa atgcgtggtt ctggtgagat
    11041 ttttggaacc agacagtcag gacttccaga gttccaagtg gctgatatta tcgaagattt
    11101 tccgatttta gaagaagcaa gaaaggttgc tagctacatt agttctatag aagcttggca
    11161 agaagatcca gagtggcgca tgattgccct tcatctggaa aagaaagaac atctggatta
    11221 agctttctct aaggaaaact taagctagtt tttagatttg gctcttatac taaagtcatc
    11281 aaaaagaaac gaggactctc atatgacagt aacgattaaa gtaaattacc aaaccacttt
    11341 ccaaaagaag gaagcaaaaa actagtataa acagaagaga gagcgaaatg ctctttttcg
    11401 tttctaaaac tactttcagc ccatcatcct aaaagtaaag aatctaaatt cactttctat
    11461 ttatccttct ttcttgcatt gattacatag atatgctaca gttgtggtaa cgattacaaa
    11521 ataaaaggag catgctatga aaaatccagc tttactagaa gaaattaaga cctatagagg
    11581 aagggatgag gttccggaag actttgatgc tttctgggat ggggaagtga aaaatgtttc
    11641 cacgcttcca tcctaccact tggaggaaag agatttccac attcctcaag tcaagtgcta
    11701 tgagttaaca tttgaaggaa gcaaggaagg aaaggtctat gcacgcattg ttcttccaaa
    11761 gagtgaggag aaggttccac taatcttcca ttttcatggt tatatgggac gtggctggga
    11821 ctgggccgac atgctgggct tcaccgtagc tggttacggt gttgtttcca tggatgtgcg
    11881 gggccagtca ggttactcac aagacggctt gcgttctcct ttaggaaata ccgtgaaggg
    11941 gcatattatc cgtggtgcta tggaaggtcg ggaccacctc ttttataagg atgtttatct
    12001 ggatatttac cagttggtcg aaattgttgc tagtctgtct caggttgatg agaagcgtct
    12061 ttctagctat ggtgcctcac aaaggagggg ctctagctct agttgcagca gcgctcaatc
    12121 ctcgaattca gaaaacagtt gccatttatc ccttcttgtc agacttcaga cgggtgattg
    12181 agattggtaa tactagcgag gcttacgacg aacttttccg ttatttcaag tttcacgacc
    12241 ccttccatga aacagaggag gaaatcatgg cgacccttgc ctatatcgat gtcaaaaatc
    12301 ttgcccatcg tatccaaggt gaggttaaga tgattacggg cttggacgac gatgtttgct
    12361 atcccattac ccagtttgcg atttataatc gtctgacctg cgataaaacc tatcgcatca
    12421 tgcctgagta tggtcacgaa gccatgaatg tatttgtcaa tgaccaagtc tacaactggc
    12481 tctgtggaag tgagattcct tttaaatatc taaaataagg agtcgactct aagcacaaaa
    12541 tcttaaaaat tacaaacacg catagtatca ggggattaaa aaaacttgat actatgcgtt
    12601 ttatcatgga aatatagtaa aatgaaacaa gaataggaca aaacgatcag gagagtcaaa
    12661 tcgatttcta acaatgtttt agaagaaaat gtgtactatt ctagtttcaa tctattatat
    12721 ttatagaatt ttttgttgct agatttgtca aattgcttaa aataattttt ttcagaaagc
    12781 aaaagccgat acctatcgag tagggtagtt cttgctatcg tcaggcttgt ctgtaggtgt
    12841 taatactttt caaaaatctc tttaaaccac gtcagcttcg ccttgccgta ggtatggtta
    12901 ctgacttcgt cagttctatc cacaacctca aaacagtgtt ttgagctgac ttcgtcagtt
    12961 ctatctgcca cctcaaaaca gtgttttgag ctgacttcgt cagttctatc cacaacctca
    13021 aaacagtgtt ttgagctgac ttcgtcagtt ctatccacaa cctcaaaaca gtgttttgag
    13081 ctgacttcgt cagttctatc tgccacctca aaacagtgtt ttgagctgac ttcgtcagtt
    13141 ctatccacaa cctcaaaaca gtgttttgag ctgacttcgt cagttctatc tgccacctca
    13201 aaacagtgtt ttgagctgac ttcgtcagtt ctatctgcca cctcaaaacg gtgttttgag
    13261 ctgacttcgt cagttctatc tgccacctca aaacggtgtt ttgagctgac ttcgtcagtt
    13321 ctatctgcca cctcaaaacg gtgttttgag ctgacttcgt cagttctatc tgccacctca
    13381 aaacggtgtt ttgagctgac tttgtcagtc ttatctacag cctcaaaaca gtgttttgag
    13441 catcatgcgg ctagcttctt agtttgctct ttgattttca ttgagtataa aaacagatga
    13501 gtttctgttt tctttttatg gactataaat gttcagctga aactactttc aaggacatta
    13561 ttatataaaa gaattt
//
LOCUS       DAVHIZ010000049        12886 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.051, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000049 DAVHIZ010000000
VERSION     DAVHIZ010000049.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 12886)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12886)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12886
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.051"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1072
                     /gene="dnaN"
                     /locus_tag="VVO18_001625"
     CDS             <1..1072
                     /gene="dnaN"
                     /locus_tag="VVO18_001625"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581170.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="DNA polymerase III subunit beta"
                     /protein_id="HEU5586740.1"
                     /translation="SSKNAIPILSTVKIDVTNEGITLIGSNGQISIENFISQKNEDAG
                     LLITSLGSILLEASFFINVVSSLPDVTLDFKEIEQNQIVLTSGKSEITLKGKDSEQYP
                     RIQEISASTPLILETKLLKKIINETAFAASTQESRPILTGVHFVLSQHKELKTVATDS
                     HRLSQKKLTLEKNSDDFDVVIPSRSLREFSAVFTDDIETVEIFFANNQILFRSENISF
                     YTRLLEGNYPDTDRLIPTDFNTTITFNVVNLRQSMERARLLSSATQNGTVKLEIKDGV
                     VSAHVHSPEVGKVNEEIDTDQVTGEDLTISFNPTYLIDSLKALNSEKVTISFISAVRP
                     FTLVPADTDEDFMQLITPVRTN"
     gene            1137..1331
                     /locus_tag="VVO18_001626"
     CDS             1137..1331
                     /locus_tag="VVO18_001626"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF951 family protein"
                     /protein_id="HEU5586741.1"
                     /translation="MYQVGNFVEMKKSHACTIKSTGKKANRWEITRVGADIKIKCSNC
                     EHVVMMGRYDFERKMNKIID"
     gene            1415..2530
                     /gene="ychF"
                     /locus_tag="VVO18_001627"
     CDS             1415..2530
                     /gene="ychF"
                     /locus_tag="VVO18_001627"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="redox-regulated ATPase YchF"
                     /protein_id="HEU5586742.1"
                     /translation="MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMV
                     EVPDERLQKLTEMITPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREVDAIVH
                     VVRAFDDENVMREQGREDAFVDPLADIDTINLELILADLESVNKRYARVEKMARTQKD
                     KESVAEFNVLQKIKPVLEDGKSARTIEFTDEEQKVVKGLFLLTTKPVLYVANVDEDVV
                     SEPDSIDYVKQIREFAATENAEVVVISARAEEEISELNDEDKKEFLEAIGLTESGVDK
                     LTRAAYHLLGLGTYFTAGEKEVRAWTFKRGMKAPKAAGIIHSDFEKGFIRAVTMSYED
                     LVKYGSEKAVKEAGRLREEGKEYIVQDGDIMEFRFNV"
     gene            2601..3170
                     /locus_tag="VVO18_001628"
     CDS             2601..3170
                     /locus_tag="VVO18_001628"
                     /EC_number="3.1.1.29"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="HEU5586743.1"
                     /translation="MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIF
                     QADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKI
                     RLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
                     LQSVDKVDDSVNYYLQEKNFEKTMQRYNG"
     gene            3171..6680
                     /gene="mfd"
                     /locus_tag="VVO18_001629"
     CDS             3171..6680
                     /gene="mfd"
                     /locus_tag="VVO18_001629"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000258090.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription-repair coupling factor"
                     /protein_id="HEU5586744.1"
                     /translation="MVTLLDLFSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASS
                     LEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRV
                     EALRFLTDSSKKGILVCNIVASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKENG
                     YRKVTQVQTQGEFSLRGDILDIFEISQLEPCRIEFFGDEIDGIRSFEVETQLSKENKT
                     ELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSRK
                     FLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERDLAQYFTEELQNSKAFSDM
                     QYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIER
                     YKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTSICKESVNLIEGNLRHGFHF
                     VDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLGI
                     ETIEIKGIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKAK
                     QKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEEI
                     KRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNFK
                     ERFQNFAVNVDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMII
                     DEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPV
                     QTYVLEKNDSVIRDAVLREMERGGQVYYLYNKVDTIVQKVSELQELIPEASIGYVHGR
                     MSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGR
                     VGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLLG
                     KSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELILQIDAYLPDTYISDQ
                     RHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQRV
                     ERKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNKKDYEI
                     LEGLLIFGESLLEIKESKEKNSI"
     gene            6738..7004
                     /locus_tag="VVO18_001630"
     CDS             6738..7004
                     /locus_tag="VVO18_001630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001234972.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-binding S4 domain-containing protein"
                     /protein_id="HEU5586745.1"
                     /translation="MRLDKYLKVSRIIKRRTVAKEVADKGRIKVNGILAKSSTDLKVN
                     DQVEIRFGNKLLLVKVLEMKDSTKKEDAAGMYEIISETRVEENV"
     gene            6997..7365
                     /locus_tag="VVO18_001631"
     CDS             6997..7365
                     /locus_tag="VVO18_001631"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397271.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="septum formation initiator family protein"
                     /protein_id="HEU5586746.1"
                     /translation="MSKNIVQLNNSFIQNEYQRRRYLMKERQKRNRFMGGVLILIMLL
                     FILPTFNLAQSYQQLLQRRQQLADLQTQYQTLSDEKDKETAFATKLKDEDYAAKYTRA
                     KYYYSKSREKVYTIPDLLQR"
     gene            7485..8753
                     /locus_tag="VVO18_001632"
     CDS             7485..8753
                     /locus_tag="VVO18_001632"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224749.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class A beta-lactamase-related serine hydrolase"
                     /protein_id="HEU5586747.1"
                     /translation="MRKFLIILLLPSFLTISKVVSTEKEVVYTSKEIYYLSQSDFGIY
                     FREKLSSPMVYGEVPVYANEDLVVESGKLTPKTSFQITEWRLNKQGIPVFKLSNHQFI
                     AADKRFLYDQSEVTPTIKKVWLESDFKLYNSPYDLKEVKSSLSAYSQVSIDKTMFVEG
                     REFLHIDQAGWVAKESTSEEDNRMSKVQEMLSEKYQKDSFSIYVKQLTTGKEAGINQD
                     EKMYAASVLKLSYLYYTQEKINEGLYQLDTTVKYVSAVNDFPGSYKPEGSGSLPKKED
                     NKEYSLKDLITKVSKESDNVAHNLLGYYISNQSDATFKSKMSAIMGDDWDPKEKLISS
                     KMAGKFMEAIYNQNGFVLESLTKTDFDSQRIAKGVSVKVAHKIGDADEFKHDTGVVYA
                     DSPFILSIFTKNSDYDTISKIAKDVYEVLK"
     gene            8750..10027
                     /gene="tilS"
                     /locus_tag="VVO18_001633"
     CDS             8750..10027
                     /gene="tilS"
                     /locus_tag="VVO18_001633"
                     /EC_number="6.3.4.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004269826.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="HEU5586748.1"
                     /translation="MREPDFLNHFLKKGYFKKHAKAVLALSGGLDSMFLFKVLSTYQK
                     ELEIELILAHVNHKQRIESDWEEKELRKLAAEAELPIYISNFSGEFSEARARNFRYDF
                     FQEVMKKTGATALVTAHHADDQVETIFMRLIRGTRLRYLSGIKEKQVVGEIEIIRPFL
                     HFQKKDFPSIFHFEDTSNQENHYFRNRIRNSYLPELEKENPRFRDAILGIGNEILDYD
                     LAIAELSNNINVEDLQQLFSYSESTQRVLLQTYLNRFPDLNLTKAQFAEVQQILKFKS
                     QYRHPIKNGYELIKEYQQFQICKISPQADEKEDELVLHYQNQVAYQGYLFSFGLPLEG
                     ELIQQIPVSRETSIHIRHRKTGDVLIKNGHRKKLRRLFIDLKIPMEKRNSALIIEQFG
                     EIVSILGIATNNLSKKTKNDIMNTVLYIEKIDR"
     gene            10031..10573
                     /gene="hpt"
                     /locus_tag="VVO18_001634"
     CDS             10031..10573
                     /gene="hpt"
                     /locus_tag="VVO18_001634"
                     /EC_number="2.4.2.8"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520984.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypoxanthine phosphoribosyltransferase"
                     /protein_id="HEU5586749.1"
                     /translation="MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKG
                     SIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDII
                     DTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
                     KENYRNLPYIGVLKEEVYSN"
     gene            10589..12547
                     /gene="ftsH"
                     /locus_tag="VVO18_001635"
     CDS             10589..12547
                     /gene="ftsH"
                     /locus_tag="VVO18_001635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744538.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent zinc metalloprotease FtsH"
                     /protein_id="HEU5586750.1"
                     /translation="MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYT
                     ELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTI
                     LPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGG
                     GNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGAR
                     IPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAK
                     KAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNR
                     SDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFV
                     GADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHE
                     AGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGR
                     VAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMLGAQSPQKS
                     ISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYE
                     TGKMPEAVEEESHALSYDEVKSKMNDEK"
     gene            12669..>12886
                     /locus_tag="VVO18_001636"
     CDS             12669..>12886
                     /locus_tag="VVO18_001636"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU5586751.1"
                     /translation="MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISR
                     EEGLVDDIPRLRKYFKTKFRNRILDYIR"
BASE COUNT         4428 a         1928 c         2644 g         3886 t
ORIGIN      
        1 tagttctaaa aatgccattc ctattttatc aacagtaaaa attgacgtga ccaatgaagg
       61 tattacttta attggttcaa atggtcaaat ttcaattgaa aattttattt ctcaaaaaaa
      121 tgaagatgct ggtttgttaa ttacttcttt aggttcgatc cttcttgaag cttctttctt
      181 tatcaatgta gtatctagtt tacctgatgt aactcttgat tttaaagaaa ttgaacaaaa
      241 tcaaattgtt ttaaccagtg gcaaatcaga aattacccta aaaggaaaag atagcgaaca
      301 atatccacga atccaagaaa tttcagcaag cactccttta atacttgaaa caaaattact
      361 caagaaaatt attaatgaaa cagcctttgc tgcaagtaca caagagagtc gtccgatttt
      421 aacaggtgtc cacttcgtat tgagtcaaca caaagagtta aaaacagttg caacagactc
      481 tcatcgccta agccagaaaa aattgactct tgaaaaaaat agtgatgatt ttgatgtcgt
      541 aattcctagc cgttctctac gcgaattttc agcggtattt acagatgata tcgaaactgt
      601 agagattttc tttgccaata accaaatcct ctttagaagc gaaaatatta gcttctatac
      661 tcgtctccta gaaggaaact atcctgatac agatcgcttg attccaacag actttaacac
      721 tactattact tttaatgtgg taaacttacg ccagtcaatg gagcgtgccc gtcttttatc
      781 aagtgcgact caaaatggta ctgtgaaact tgaaattaag gatggggttg ttagcgccca
      841 tgttcactct ccagaagttg gtaaagtaaa cgaagaaatc gatactgatc aggttactgg
      901 tgaagatttg accattagtt tcaacccaac ttacttgatt gattctctta aagctttaaa
      961 tagcgaaaag gtgactatta gctttatctc agctgttcgt ccatttactc ttgtgccagc
     1021 agatactgac gaagacttca tgcagctcat tacaccagtt cgtacaaatt aagtgaaaga
     1081 ggttgagcct ggctcgcctc ttttatgata taatcgaaaa agaaaaggag agtagtatgt
     1141 atcaagttgg aaattttgtt gagatgaaaa aatcacacgc ttgtacaatc aagtcgactg
     1201 gtaaaaaggc taatcgttgg gaaattacac gtgtaggagc agatatcaaa ataaaatgta
     1261 gtaattgtga gcatgttgtc atgatggggc gatatgattt tgagcgaaaa atgaataaaa
     1321 ttattgactg agaaccctta gttagagggt tagcacttta tccctttttg tgttataata
     1381 ttagggattg aaatgaaaac ggagaatgag aaatatggct ttgacagcag gtatcgttgg
     1441 tttgccaaac gttggtaaat caacactatt taatgcaatt acaaaagcag gagcagaggc
     1501 agcaaactac ccatttgcga cgattgatcc aaatgttgga atggtggaag ttccagatga
     1561 acgcctacaa aaactaactg aaatgataac tcctaaaaag acagttccca caacatttga
     1621 atttacagat attgcaggga ttgtaaaagg agcttcaaaa ggagaggggc tagggaataa
     1681 attcttggcc aatattcgtg aagtagatgc gattgttcac gtagttcgtg cttttgatga
     1741 tgaaaatgta atgcgcgagc aaggacgtga agacgccttt gtagatccac ttgcagatat
     1801 tgataccatt aatctggaat tgattcttgc tgacttagaa tcagtgaaca aacgatatgc
     1861 gcgtgtagaa aagatggcac gtacgcaaaa agataaagaa tcagtagcag aattcaatgt
     1921 tcttcaaaag attaaaccag tcctagaaga cgggaaatca gctcgtacca ttgaatttac
     1981 agatgaggaa caaaaggttg tcaaaggtct tttccttttg acgactaaac cagttcttta
     2041 tgtagctaat gtggacgagg atgtggtttc agaacctgac tctatcgact atgtcaaaca
     2101 aattcgtgaa tttgcagcga cagaaaatgc tgaagtagtc gttatttctg cgcgtgctga
     2161 ggaagaaatt tctgaattga atgatgaaga taaaaaagag tttcttgaag ccattggttt
     2221 gacagaatca ggtgtagata agttgacgcg tgcagcttac cacttgcttg gattgggaac
     2281 ttacttcaca gctggtgaaa aagaagttcg cgcttggact ttcaaacgtg gtatgaaggc
     2341 tcctaaagca gctggtatta tccattcaga ctttgaaaaa ggctttattc gtgcagtaac
     2401 catgtcatat gaagatctag tgaaatacgg atctgaaaag gccgtaaaag aagctggacg
     2461 cttgcgtgaa gaaggaaaag aatatatcgt tcaagatggc gatatcatgg aattccgctt
     2521 taatgtctaa aaattaataa atggtgttaa ttaggttgga aaaaaattcc aacccttttg
     2581 gcttttgaaa ggaaaaataa atgaccaaat tacttgtagg cttgggaaat ccaggggata
     2641 aatattttga aacaaaacac aatgttggtt tcatgttgat tgatcaacta gcgaagaaac
     2701 agaatgtcac ttttacacac gataagatat ttcaagctga cctagcatcc tttttcctaa
     2761 atggagaaaa aatttatctg gttaaaccaa cgacctttat gaatgaaagt ggaaaagcag
     2821 ttcatgcttt attaacttac tatggtttgg atattgacga tttacttatc atttacgatg
     2881 atcttgacat ggaagttggg aaaattcgtt taagagcaaa aggctcagca ggtggtcata
     2941 atggtatcaa gtctattatt caacatatag gaactcaggt ctttaaccgt gttaagattg
     3001 gaattggaag acctaaaaat ggtatgtcag ttgttcatca tgttttgagt aagtttgaca
     3061 gggatgatta tatcggtatt ttacagtctg ttgacaaagt tgacgattct gtaaactact
     3121 atttacaaga gaaaaatttt gagaaaacaa tgcagaggta taacggataa atggtgacct
     3181 tattagattt attctcagaa aatgatcaga ttaaaaaatg gcatcaaaat ttaacagata
     3241 agaaaagaca actaatactt ggtttatcaa catctactaa ggctcttgca attgcaagca
     3301 gtttagaaaa agaagatagg attgtgttat tgacgtcaac ttatggagaa gcagaaggac
     3361 ttgttagtga tcttatttct atcttgggtg aggaactcgt ctatccattt ttggtagatg
     3421 atgctcctat ggtggagttt ttgatgtctt cacaggaaaa aattatttca cgggttgaag
     3481 ccttgcgttt tttgactgat tcatctaaga aagggatttt agtttgtaat atcgtagcaa
     3541 gtcgattgat tttaccgtct cccaatgcat tcaaagatag tattgtaaaa atctcagttg
     3601 gtgaagaata tgatcaacac gcgtttatcc atcagttaaa ggaaaatggc tatcgaaaag
     3661 ttactcaagt acaaactcag ggcgaattta gtcttcgagg agatatttta gatatttttg
     3721 aaatatccca gttagaacct tgtcgaattg agttttttgg tgatgaaatt gatggtatca
     3781 ggtcatttga agtagaaaca caattatcga aagaaaataa gacagaactc actatctttc
     3841 cagctagtga tatgcttttg agagaaaagg attatcaacg aggacagtca gctttagaaa
     3901 aacaaatttc aaaaacttta tcacctattt tgaaatcata cctagaagaa attctttcaa
     3961 gttttcacca aaaacaaagt catgcagact ctcggaagtt tttatctttg tgctatgata
     4021 agacatggac tgtctttgat tatattgaaa aagatactcc aatattcttt gatgattatc
     4081 aaaaattgat gaatcagtat gaagtctttg aaagagactt agcgcagtac tttacagaag
     4141 aattacagaa tagtaaagca ttttctgata tgcagtattt ttctgatatt gaacaaatct
     4201 ataaaaaaca aagtccagtg acctttttct ctaatcttca aaagggttta ggaaatctca
     4261 aatttgacaa aatttatcaa ttcaatcaat atcctatgca ggaatttttc aatcagtttt
     4321 cttttctaaa agaagaaatt gaacgatata aaaaaatgga ttacaccatt attctgcagt
     4381 ctagcaattc aatgggaagt aaaacattgg aggatatgtt agaggaatat cagattaaat
     4441 tggattctag agataagaca agtatctgta aagaatctgt aaacttaata gagggtaatc
     4501 tcagacatgg ttttcatttt gtagatgaaa agattttatt gataactgaa catgagattt
     4561 ttcaaaagaa attaaagcgt cgttttcgaa gacaacatgt ttcaaatgca gagagattaa
     4621 aagattacaa tgaacttgaa aaaggggact atgttgtcca tcatatccat gggattggtc
     4681 aatatctagg aattgaaacc attgaaatca agggaattca tcgcgattat gtcagtgtcc
     4741 agtaccaaaa tggtgatcaa atttctattc ccgtggaaca gattcatcta ctgtccaaat
     4801 atatttcaag tgatggtaaa gctccaaaac tcaataaatt aaatgacggt cattttaaaa
     4861 aggccaagca aaaggttaag aaccaggtag aggatatagc tgatgattta atcaaactct
     4921 actctgaacg tagtcagttg aagggttttg ctttctcagc tgatgatgat gatcaagatg
     4981 cctttgatga tgctttccct tatgttgaaa cggatgatca acttcgtagt attgaggaaa
     5041 tcaagaggga tatgcaggct tctcagccaa tggatcgact tttagttggg gatgttggtt
     5101 ttggaaagac tgaagttgct atgcgtgcag cctttaaagc agtcaatgat cacaaacagg
     5161 ttgtcattct agttccgacg acggttttag cgcaacagca ctatacgaat tttaaggaac
     5221 gattccaaaa ttttgcagtt aatgttgatg tgttgagtcg ctttagaagt aaaaaagagc
     5281 agactgcaac acttgaaaaa ttgaaaaacg gtcaagtcga tattttgatt ggaacacatc
     5341 gtgttttgtc aaaagatgtt gtgtttgctg atttgggctt gatgattatt gatgaggaac
     5401 agcgatttgg tgtcaagcat aaggaaactt tgaaagaact gaagaaacaa gtggatgtcc
     5461 taaccttgac cgctacgcca atccctcgta ccctccatat gtctatgctg ggaatcagag
     5521 atttgtctgt tattgaaact ccgccgacta atcgctatcc tgttcagacc tatgttttgg
     5581 aaaagaatga tagtgtcatt cgtgatgctg tcttgcgtga aatggagcgt ggaggtcaag
     5641 tttactatct ttacaacaaa gttgacacaa ttgttcagaa ggtttcagaa ttacaggagt
     5701 tgattccgga ggcttcgatt ggatatgttc atggtcgaat gagtgaagtc cagttggaaa
     5761 atactctatt agactttatt gagggacaat acgatatctt ggtgacgact actattattg
     5821 agacaggggt ggacattcca aatgctaata ctttatttat tgaaaatgcg gaccatatgg
     5881 gcttgtcaac cttatatcag ttaagaggaa gagtcggtcg tagtaatcgt attgcttatg
     5941 cttatctcat gtatcgtcca gaaaaatcaa tcagtgaagt ctctgaaaag agattagaag
     6001 cgattaaagg atttacagaa ttgggctctg gctttaagat tgcaatgcga gatctttcga
     6061 ttcgtggagc aggaaatctt ttaggaaaat cccagtctgg tttcattgat tctgttggtt
     6121 ttgaattgta ttcgcagtta ttagaggaag ctattgctaa acgaaacggt aatgctaacg
     6181 ctaacacaag aaccaaaggg aatgctgagt tgattttgca aattgatgcc tatcttcctg
     6241 atacttatat ttctgatcaa cgacataaga ttgaaattta caagaaaatt cgtcaaattg
     6301 acaaccgtgt caattatgaa gagttacaag aggagttgat agaccgtttt ggagaatacc
     6361 cagatgtagt agcctatctt ttagagattg gtttggtcaa atcatacttg gacaaggtct
     6421 ttgttcaacg tgtggaaaga aaagataata aaattacaat tcaatttgaa aaagtcactc
     6481 aacgactgtt tttagctcaa gattatttta aagctttatc cgtaacgaac ttaaaagcag
     6541 gcatcgctga gaataaggga ttaatggagc ttgtatttga tgtccaaaat aagaaagatt
     6601 atgaaatttt agaaggtctg ctgatttttg gagaaagttt attagagata aaagagtcta
     6661 aggaaaaaaa ttccatttga tatttttctt ctataaaata gataaaaatg gtacaataat
     6721 aaattgaggt aataaggatg agattagata aatatttaaa agtatcgcga attatcaagc
     6781 gtcgtacagt cgcaaaggaa gtagcagata aaggtagaat caaggttaat ggaatcttgg
     6841 ccaaaagttc aacggacttg aaagttaatg accaagttga aattcgcttt ggcaataagt
     6901 tgctgcttgt aaaagtacta gagatgaaag atagtacaaa aaaagaagat gcagcaggaa
     6961 tgtatgaaat tatcagtgaa acacgggtag aagaaaatgt ctaaaaatat tgtacaattg
     7021 aataattctt ttattcaaaa tgaataccaa cgtcgtcgct acctgatgaa agaacgacaa
     7081 aaacggaatc gttttatggg aggggtattg attttgatta tgctattatt tatcttgcca
     7141 acttttaatt tagcgcagag ttatcagcaa ttactccaaa gacgtcagca attagcagac
     7201 ttgcaaactc agtatcaaac tttgagtgat gaaaaggata aggagacagc atttgctacc
     7261 aagttgaaag atgaagatta tgctgctaaa tatacacgag cgaagtacta ttattctaag
     7321 tcgagggaaa aagtttatac gattcctgac ttgcttcaaa ggtgataaaa tggaaaattt
     7381 attagacgta atagagcaat ttttgagttt gtcagatgaa aagctggaag aattggctga
     7441 taaaaatcaa ttattgcgtt tacaagaaga aaaggaaagg aagaatgcgt aaattcttaa
     7501 ttattttgtt gctaccaagt tttttgacca tttcaaaagt cgttagcaca gaaaaagaag
     7561 tcgtctatac ttcgaaagaa atttattacc tttcacaatc tgactttggt atttatttta
     7621 gagaaaaatt aagttctccc atggtttatg gagaggttcc tgtttatgcg aatgaagatt
     7681 tagtagtgga atctgggaaa ttgactccca aaacaagttt tcaaataacc gagtggcgct
     7741 taaataaaca aggaattcca gtatttaagc tatcaaatca tcaatttata gctgcggaca
     7801 aacgattttt atatgatcaa tcagaggtaa ctccaacaat aaaaaaagta tggttagaat
     7861 ctgactttaa actgtacaat agtccttatg atttaaaaga agtgaaatca tccttatcag
     7921 cttattcgca agtatcaatc gacaagacca tgtttgtaga aggaagagaa tttctacata
     7981 ttgatcaggc tggatgggta gctaaagaat caacttctga agaagataat cggatgagta
     8041 aagttcaaga aatgttatct gaaaaatatc agaaagattc tttctctatt tatgttaagc
     8101 aactgactac tggaaaagaa gctggtatca atcaagatga aaagatgtat gcagccagcg
     8161 ttttgaaact ctcttatctc tattatacgc aagaaaaaat aaatgagggt ctttatcagt
     8221 tagatacgac tgtaaaatac gtatctgcag tcaatgattt tccaggttct tataaaccag
     8281 agggaagtgg tagtcttcct aaaaaagaag ataataaaga atattcttta aaggatttaa
     8341 ttacgaaagt atcaaaagaa tctgataatg tagctcataa tctattggga tattacattt
     8401 caaaccaatc tgatgccaca ttcaaatcca agatgtctgc cattatggga gatgattggg
     8461 atccaaaaga aaaattgatt tcttctaaga tggccgggaa gtttatggaa gctatttata
     8521 atcaaaatgg atttgtgcta gagtctttga ctaaaacaga ttttgatagt cagcgaattg
     8581 ccaaaggtgt ttctgttaaa gtagctcata aaattggaga tgcggatgaa tttaagcatg
     8641 atacgggtgt tgtctatgca gattctccat ttattctttc tattttcact aagaattctg
     8701 attatgatac gatttctaag atagccaagg atgtttatga ggttctaaaa tgagggaacc
     8761 agatttttta aatcattttc tcaagaaggg atatttcaaa aagcatgcta aggcggttct
     8821 agctctttct ggtggattag attctatgtt tctatttaag gtattgtcta cttatcaaaa
     8881 agagttagag attgaattga ttctagctca tgtgaatcat aagcagagaa ttgaatcaga
     8941 ttgggaagaa aaggaattaa ggaagttggc tgctgaagca gagcttccta tttatatcag
     9001 caatttttca ggagaatttt cagaagcgcg tgcacgaaat tttcgttatg atttttttca
     9061 agaggtcatg aaaaagacag gtgcgacagc tttagtcact gcccaccatg ctgatgatca
     9121 ggtggaaacg atttttatgc gcttgattcg aggaactcgc ttgcgctatc tatcaggaat
     9181 taaggagaag caagtagtcg gagagataga aatcattcgt cccttcttgc attttcagaa
     9241 aaaagacttt ccatcaattt ttcactttga agatacatca aatcaggaga atcattattt
     9301 tcgaaatcgt attcgaaatt cttacttacc agaattggaa aaagaaaatc ctcgatttag
     9361 ggatgcaatc ttaggcattg gcaatgaaat tttagattat gatttggcaa tagctgaatt
     9421 atctaacaat attaatgtgg aagatttaca gcagttattt tcttactctg agtctacaca
     9481 aagagtttta cttcaaactt atctgaatcg ttttccagat ttgaatctta caaaagctca
     9541 gtttgctgaa gttcagcaga ttttaaaatt taaaagccag tatcgtcatc cgattaaaaa
     9601 tggctatgaa ttgataaaag agtaccaaca gtttcagatt tgtaaaatca gtccgcaggc
     9661 tgatgaaaag gaagatgaac ttgtgttaca ctatcaaaat caggtagctt atcaaggata
     9721 tttattttct tttggacttc cattagaagg tgaattaatt caacaaatac ctgtttcacg
     9781 tgaaacatcc atacacattc gtcatcgaaa aacaggagat gttttgatta aaaatgggca
     9841 tagaaaaaaa ctcagacgtt tatttattga tttgaaaatc cctatggaaa agagaaactc
     9901 tgctcttatt attgagcaat ttggtgaaat tgtctcaatt ttgggaattg cgaccaataa
     9961 tttgagtaaa aaaacgaaaa atgatataat gaacactgta ctttatatag aaaaaataga
    10021 taggtaaaaa atgttagaaa acgatattaa aaaagtcctc gtttcacacg atgaaattac
    10081 agaagcagct aaaaaactag gtgctcaatt aactaaagac tatgcaggaa aaaatccaat
    10141 cttagttggg attttaaaag gatctattcc ttttatggct gaattggtca aacatattga
    10201 tacacatatt gaaatggact tcatgatggt ttctagctac catggtggaa cagcaagtag
    10261 tggtgttatc aatattaaac aagatgtgac tcaagatatc aaaggaagac atgttctatt
    10321 tgtagaagat atcattgata caggtcaaac tttgaagaat ttgcgagata tgtttaaaga
    10381 aagagaagca gcttctgtta aaattgcaac cttgttggat aaaccagaag gacgtgttgt
    10441 agaaattgag gcagactata cttgctttac tatcccaaat gagtttgtag taggttatgg
    10501 tttagactac aaagaaaatt atcgtaatct tccttatatt ggagtattga aagaggaagt
    10561 gtattcaaat tagaaagaat aatctttaat gaaaaaacaa aataatggtt taattaaaaa
    10621 tccttttcta tggttattat ttatcttttt ccttgtgaca ggattccagt atttctattc
    10681 tgggaataac tcaggaggaa gtcagcaaat caactatact gagttggtac aagaaattac
    10741 cgatggtaat gtaaaagaat taacttacca accaaatggt agtgttatcg aagtttctgg
    10801 tgtctataaa aatcctaaaa caagtaaaga aggaacaggt attcagtttt tcacgccatc
    10861 tgttactaag gtagagaaat ttaccagcac tattcttcct gcagatacta ccgtatcaga
    10921 attgcaaaaa cttgctactg accataaagc agaagtaact gttaagcatg aaagttcaag
    10981 tggtatatgg attaatctac tcgtatccat tgtgccattt ggaattctat tcttcttcct
    11041 attctctatg atgggaaata tgggaggagg caatggccgt aatccaatga gttttggacg
    11101 tagtaaggct aaagcagcaa ataaagaaga tattaaagta agattttcag atgttgctgg
    11161 agctgaggaa gaaaaacaag aactagttga agttgttgag ttcttaaaag atccaaaacg
    11221 attcacaaaa cttggagccc gtattccagc aggtgttctt ttggagggac ctccggggac
    11281 aggtaagact ttgcttgcta aggcagtcgc tggagaagca ggtgttccat tctttagtat
    11341 ctcaggttct gactttgtag aaatgtttgt cggagttgga gctagtcgtg ttcgctctct
    11401 ttttgaggat gccaaaaaag cagcaccagc tatcatcttt atcgatgaaa ttgatgctgt
    11461 tggacgtcaa cgtggagtcg gtctcggcgg aggtaatgac gaacgtgaac aaaccttgaa
    11521 ccaacttttg attgagatgg atggttttga gggaaatgaa gggattatcg tcatcgctgc
    11581 gacaaaccgt tcagatgtac ttgatcctgc ccttttgcgt ccaggacgtt ttgatagaaa
    11641 agtattggtt ggccgtcctg atgttaaagg tcgtgaagca atcttgaaag ttcacgctaa
    11701 gaacaagcct ttagcagaag atgttgattt gaaattagtg gctcaacaaa ctccaggctt
    11761 tgttggtgct gatttagaga atgtcttgaa tgaagcagct ttagttgctg ctcgtcgcaa
    11821 taaatcgata attgatgctt cagatattga tgaagcagaa gatagagtta ttgctggacc
    11881 ttctaagaaa gataagacag tttcacaaaa agaacgagaa ttggttgctt accatgaggc
    11941 aggacatacc attgttggtc tagtcttgtc gaatgctcgc gttgtccata aggttacaat
    12001 tgtaccacgc ggccgtgcag gcggatacat gattgcactt cctaaagagg atcaaatgct
    12061 tctatctaaa gaagatatga aagagcaatt ggctggctta atgggtggac gtgtagctga
    12121 agaaattatc tttaatgtcc aaactacagg agcttcaaac gactttgaac aagcgacaca
    12181 aatggcacgt gcaatggtta cagagtacgg tatgagtgaa aaacttggcc cagtacaata
    12241 tgaaggaaac catgctatgc ttggtgcaca gagtcctcaa aaatcaattt cagaacaaac
    12301 agcttatgaa attgatgaag aggttcgttc attattaaat gaggcacgaa ataaagctgc
    12361 tgaaattatt cagtcaaatc gtgaaactca caagttaatt gcagaagcat tattgaaata
    12421 cgaaacattg gatagtacac aaattaaagc tctttacgaa acaggaaaga tgcctgaagc
    12481 agtagaagag gaatctcatg cactatccta tgatgaagta aagtcaaaaa tgaatgacga
    12541 aaaataaccc tgagagaggc tggagcctct cttttttgtg cagtttagga gctaaaggga
    12601 acagaatgga gaaaatggaa caaatgtgtt ttctaatctg ttagactgta tctagaaagg
    12661 ggaaaattat gattaaagaa ttgtatgaag aagtccaagg gactgtgtat aagtgtagaa
    12721 atgaatatta ccttcattta tgggaattgt cggattggga ccaagaaggc atgctctgct
    12781 tacatgaatt gattagtaga gaagaaggac tggtagacga tattccacgt ttaaggaaat
    12841 atttcaagac caagtttcga aatcgaattt tagactatat ccgtaa
//
LOCUS       DAVHIZ010000050        11789 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.052, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000050 DAVHIZ010000000
VERSION     DAVHIZ010000050.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11789)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11789)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11789
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.052"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            140..793
                     /locus_tag="VVO18_001637"
     CDS             140..793
                     /locus_tag="VVO18_001637"
                     /EC_number="3.2.2.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="uracil-DNA glycosylase"
                     /protein_id="HEU5586752.1"
                     /translation="MEHSSWHALIKAQLPEGYFGKINQFMEQVYSQGIIYPPKEKVFQ
                     ALLTTLLEEVKVVILGQDPYHGPGQAQGLSFSVPDSIPAPPSLQNILKELSDDIGVKK
                     SHDLTAWAEQGVLLLNACLTVPAGQANGHAGQIWEPFTDAVIQVVNHLDRPVVFVLWG
                     AYARKKKALVTNPHHLIIESAHPSPLSVYRGFWGSKPFSKANAFLKETGQEPIDWLR"
     gene            803..1267
                     /locus_tag="VVO18_001638"
     CDS             803..1267
                     /locus_tag="VVO18_001638"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003012002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="HEU5586753.1"
                     /translation="MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGE
                     TPQECATREILEETGLKAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGT
                     LEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE"
     gene            1280..2548
                     /locus_tag="VVO18_001639"
     CDS             1280..2548
                     /locus_tag="VVO18_001639"
                     /EC_number="3.5.2.3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000924471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydroorotase"
                     /protein_id="HEU5586754.1"
                     /translation="MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETI
                     DATGLVVAPGLVDIHVHFREPGQTHKEDIHTGALAAAAGGFTTVVMMANTSPTISDVE
                     TLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
                     KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMI
                     AYATKAHVHIQHLSKEESVKVVEFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMN
                     PPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLG
                     LTYLVEAGELSLMELLEKMTYNPAKLYNFKAGYLAENGPADITIFDAKADRLVDSHFA
                     SKAANSPFIGETLKGQVKYTICKGQIVYQA"
     gene            2562..2822
                     /locus_tag="VVO18_001640"
     CDS             2562..2822
                     /locus_tag="VVO18_001640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398086.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586755.1"
                     /translation="MNYFRKRRERQAKSNSGIYCPAANRSKIQYETKEKADHAVQYDN
                     GGLVRSYYCRTCACWHTTSKSNKPPLSLKNYGLKLFGLDKSE"
     gene            2833..4194
                     /gene="pdrM"
                     /locus_tag="VVO18_001641"
     CDS             2833..4194
                     /gene="pdrM"
                     /locus_tag="VVO18_001641"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000278532.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sodium-coupled multidrug efflux MATE transporter
                     PdrM"
                     /protein_id="HEU5586756.1"
                     /translation="MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNT
                     MDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLS
                     VVLLGMVLFLAPTILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLT
                     KLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQ
                     EKLKALHLEKRIPLNMDNIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSSLIIASH
                     QSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTF
                     LYIFRGNVASLYGNDPKFIDLTARFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYL
                     GLLGYWGVAIPVATLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAK
                     SKR"
     gene            4348..5316
                     /locus_tag="VVO18_001642"
     CDS             4348..5316
                     /locus_tag="VVO18_001642"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844850.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiamine pyrophosphate-dependent dehydrogenase
                     E1 component subunit alpha"
                     /protein_id="HEU5586757.1"
                     /translation="MSTLDKNLLLEMFRKMEEIRRMDLKIAQLVKKGKVPGMTHFSVG
                     EEAANVGAMLALNPDDLITSNHRGHGQAIAKGIDLNGMMAEILGKYTGTCKGKGGSMH
                     IADLDAGNLGANGIVGGGMGIAVGAALSQQMQNTGKIVVCFFGDGATNEGVFHEAVNM
                     ASIWNLPVIFYCINNGYGISADIKKMTNIEHIHQRSAAYGIPGMFIEDGNNVIDVYEG
                     FQKAVDHVRSGNGPVLIESVTYRWLGHSSSDPGKYRTREEVELWKQKDPIENLRNYLI
                     ENNIASAEELEEIQAQVKEAVEASVKFAEESPFPPLESAFEDIYAD"
     gene            5332..6324
                     /locus_tag="VVO18_001643"
     CDS             5332..6324
                     /locus_tag="VVO18_001643"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000448722.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="HEU5586758.1"
                     /translation="METKTMSFRDTIILAMSEEMRRDENVFLMGEDVGVFGGDFGTSV
                     GMLEEFGPERVRDCPISEAAISGAAAGAAMTGLRPIVDMTFMDFSVIAMDNIVNQAAK
                     TRYMFGGKGQVPMTVRCAAGNGVGSAAQHSQSLESWFTHIPGLKVVAPGTPADMKGLL
                     KSSIRDNNPVIILEYKSEFNQKGEVPVDPDYTIPLGVGEIKRQGTDVTVVTYGKMLRR
                     VVQAAEELAEEGISVEIVDPRTLVPLDKDIIINSVKKTGKVVLVNDAHKTSGYIGEIS
                     AIISESEAFDYLDAPIRRCAGEDVPMPYAQNLENAMIPTVESIKDAIRKTYNKE"
     gene            6542..7585
                     /locus_tag="VVO18_001644"
     CDS             6542..7585
                     /locus_tag="VVO18_001644"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /protein_id="HEU5586759.1"
                     /translation="MADDKLRATPAARKLADDLGINLYDVSGSGANGRVHKEDVETYK
                     DTNVVRISPLAKRIALEHNIAWQEIQGTGHRGKIMKKDVLALLPENIENDSIKSPAQI
                     EKVEEVPDNVTPYGEIERIPMTPMRKVIAQRMVESYLTAPTFTLNYKVDMTEMLALRK
                     KVLEPIMEATGKKTTVTDLLSLAVVKTLMKHPYINASLTEDGKTIITHNYVNLAMAVG
                     MDNGLMTPVVYNAEKMSLSELVVAFKDVIGRTLDGKLAPSELQNSTFTISNLGMFGVQ
                     SFGPIINQPNSAILGVSSTIEKPVVVNGEIVIRPIMSLGLTIDHRVVDGMAGAKFMKD
                     LKELIETPISMLI"
     gene            7649..9334
                     /gene="lpdA"
                     /locus_tag="VVO18_001645"
     CDS             7649..9334
                     /gene="lpdA"
                     /locus_tag="VVO18_001645"
                     /EC_number="1.8.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014931946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoyl dehydrogenase"
                     /protein_id="HEU5586760.1"
                     /translation="MPKAGVDMTEGQIVQWNKKVGEFVKEGEILLEIMTDKVSMELEA
                     EEDGYLIAILKGDGETVPVTEVIGYLGEERENIPTAGAASPEASPVPVASTSNDDGKS
                     DDAFDIVVIGGGPAGYVAAIKAAQLGGKVALVEKSELGGTCLNRGCIPTKTYLHSAEI
                     IENIGHAANRGIVIENPNFTVDMEKLLETKSKVVNTLVGGVAGLLRSYGVAVHKGIGT
                     ITKDKNVLVNGSELLETKKIILAGGSKVSKINVPGMESPLVMTSDDILEMNEVPESLV
                     IIGGGVVGIELGQAFMTFGSKVTVIEMMDRIVPAMDVEVSKNLRLILERKGMTILTGT
                     KLQEIIEENGQLRIKVEGKDDIIASKALLSIGRMPDLEGIGEVEFELDRGCIKVNEYM
                     ETSVPGIYAPGDINGTKMLAHAAFRMGEVSAENALKGNHAVAKLNLTPAAIYTLPEVA
                     AVGLTEEQAREKYDVAIGKFNFAANGRAIASDAAQGFVKVIADKKYGEILGVHIIGPA
                     AAELINEASSIIEMEITVEEMLKTIHGHPTYSEVMYEAFADVLGMAIHSPKKK"
     gene            9398..10387
                     /locus_tag="VVO18_001646"
     CDS             9398..10387
                     /locus_tag="VVO18_001646"
                     /EC_number="6.3.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873976.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lipoate--protein ligase"
                     /protein_id="HEU5586761.1"
                     /translation="MKYIINHSNDTAFNIALEEYAFKHLLDEDQIFLLWINKPSIIVG
                     RHQNTIEEINRDYVRENGIEVVRRISGGGAVYHDLNNLNYTIISKEDENKAFDFKSFS
                     TPVINTLAQLGVKAEFTGRNDLEIDGKKFCGNAQAYINGRIMHHGCLLFDVDLSVLAN
                     ALKVSKDKFESKGVKSVRARVTNIINELPKKITVEKFRDLLLEYMKKEYPEMTEYVFS
                     EEELAKINHIKDTKFGTWDWNYGKSPEFNVRRGTKFTSGKVEVFANVTESKIQDIKIY
                     GDFFGIEDVAAVEDVLRGVKYEREDVLKALKTIDITRYFAGISREEIAEAVVG"
     gene            complement(10460..11530)
                     /gene="xerS"
                     /locus_tag="VVO18_001647"
     CDS             complement(10460..11530)
                     /gene="xerS"
                     /locus_tag="VVO18_001647"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000817875.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine recombinase XerS"
                     /protein_id="HEU5586762.1"
                     /translation="MKREILLERIDKLKQLMPWYVLEYYQSKLAVPYSFTTLYEYLKE
                     YDRFFSWVLESGISNADKISDIPLSVLENMSKKDMESFILYLRERPLLNANTTKQGVS
                     QTTINRTLSALSSLYKYLTEEVENDQGEPYFYRNVMKKVSTKKKKETLAARAENIKQK
                     LFLGDETEGFLTYIDQEHPQQLSNRALSSFNKNKERDLAIIALLLASGVRLSEAVNLD
                     LRDLNLKMMVIDVTRKGGKRDSVNVAAFAKPYLENYLAIRNQRYKTEKTDTALFLTLY
                     RGVPNRIDASSVEKMVAKYSEDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHAS
                     TQVTDLYTHIVNDEQKNALDSL"
BASE COUNT         3487 a         2212 c         2646 g         3444 t
ORIGIN      
        1 atagccagtc tttataaact gtattcacgt attcaaatcg tatatagtcg atttattaaa
       61 tctttagata aattgtaaaa agtggtttcc atagccactt tttgctataa tagaggcagt
      121 aaaaatgaag gagtcagcta tggaacactc gtcttggcat gctttgatta aggcgcaatt
      181 acctgagggt tatttcggga aaatcaatca gtttatggag caggtctatt ctcaggggat
      241 tatttatcca cccaaggaaa aggtttttca ggctctcttg acaacactgc ttgaagaagt
      301 taaggtggta attctagggc aagaccccta tcacggacca ggtcaagcgc agggcttgag
      361 tttttctgta cctgactcta tcccagctcc accatccttg caaaatatct tgaaagaatt
      421 gtcagatgat atcggagtta agaaatctca tgatttgaca gcttgggctg agcaaggagt
      481 cttgcttctt aatgcttgtt tgactgttcc tgctggacag gccaatggtc atgctggtca
      541 aatctgggag ccttttactg atgctgtgat tcaggtggtc aatcatctag atagaccagt
      601 cgtttttgta ctctggggag cttatgcacg taagaagaag gccttagtta ccaatcctca
      661 tcacttgatt atcgaatcag cccatccaag tcctttgtcg gtttatagag gattttgggg
      721 ttccaagccc ttttccaagg ccaatgcatt cttaaaagag acaggacaag agccaatcga
      781 ttggcttaga taaggagaaa atatgcctca gttagcgacg atttgctaca ttgataatgg
      841 gaaagaactg ctcatgctcc atcgtaataa gaaacccaat gatgtccatg aagggaaatg
      901 gattggtgtg ggtggtaagc tagagagagg agagacgccc caggaatgcg cgacgcgtga
      961 aatccttgaa gaaacagggc tcaaagccaa gccagttcta aaaggtgtca tcacttttcc
     1021 tgaatttaca ccagatttag actggtacac ctatgttttt aaggtgacgg agtttgaggg
     1081 cgacttgatt gactgcaatg aggggacgct agaatgggtt ccctatgatg aggttttgag
     1141 caagccgact tgggaaggtg accacacctt tgttgagtgg cttttagagg ataaaccctt
     1201 cttttcagcc aagtttgttt atgatgggga taaattgttg gatacccaag ttgatttcta
     1261 tgaataaagg agaaagcaga tgctactaat caaaaatggt cgtgtaatgg atcccaagtc
     1321 tggtttggat caagtttgtg atgtcttagt tcaagatggg aaaattatca aaattgcgcc
     1381 tgagatcacg gaagaaggag cagaaacgat tgatgctact ggtcttgtgg ttgctcctgg
     1441 tttggtcgat attcatgtgc atttccgtga acctggtcaa acacataaag aagacattca
     1501 tactggtgcc ctagcagccg ctgcaggtgg ttttactact gtcgtcatga tggctaatac
     1561 cagtccaacc atttcagacg tggagacttt gcaagcagtt ctccagtcag ctgccaaaga
     1621 gaagattaat gtcaagacag ttgcgaccat tactaaaaac tttaatggta aaaacttgac
     1681 tgactttaag gcactcttag aagctggtgc ggttggtttc tctgatgacg gtattccgct
     1741 tgagagcagt aagattgtca aggaagccat ggaggaagcc aaaaaactca atacctttat
     1801 cagccttcat gaggaagatc caggtttgaa cggtgttctt ggctttaatg aaaatattgc
     1861 tagagaacat ttccatatct gcggtgctac tggggtggct gagtacgcta tgatggcgcg
     1921 tgatgtcatg attgcctatg caactaaagc ccatgttcac atccagcatt tgtctaagga
     1981 agaaagtgtt aaagtagtgg agtttgctca ggggttaggt gcagaagtca cagcagaagt
     2041 agcgccacag catttctcta agacagaagc acttctttta acacaaggta gcaatgctaa
     2101 gatgaatcca ccgcttcgtt tggaatcaga ccgtcgtgcc gttatcgaag gtctcaaatc
     2161 aggtgtcatc acagttattg cgactgacca cgcgcctcat catgtagatg aaaaaaatgt
     2221 tgaggatatt accaaagcgc catctggtat gactggctta gaaacatccc tgtctctcgg
     2281 cttgacctat ttggtagaag ctggtgagtt gagcttgatg gaattacttg aaaaaatgac
     2341 atacaaccca gccaagcttt acaactttaa agcaggttac ttggctgaga atggtccagc
     2401 agatatcact atttttgatg ccaaggctga ccgccttgtg gactcccatt ttgcttccaa
     2461 agcagctaat tcaccattca tcggtgaaac cttaaaaggg caggttaaat ataccatctg
     2521 taagggacaa atcgtctatc aagcttgata ggagttagaa tatgaattat tttcgaaaac
     2581 gtagggagag acaagcgaaa tctaatagtg gaatttactg tcctgcagct aatcgttcca
     2641 aaattcaata tgaaactaaa gaaaaagctg accatgcggt tcaatatgat aacggaggtt
     2701 tagttagaag ctattattgt cgtacatgtg cgtgttggca tactacttca aaatctaata
     2761 aacctccgct aagtttgaaa aactatggtc tgaaactctt tggtttagat aaatcagaat
     2821 agaaagagaa gtatgtataa gacaaagtgt ttacgagaga agttggtatt atttttaaaa
     2881 attttcttcc caatcctgat ttaccaattt gccaattatt ctgcctcttt tgttgatact
     2941 gcaatgacag gtcaatacaa cactatggac ttggctggtg tatctatggc aaccagtatc
     3001 tggaatcctt tctttacatt tctaacaggg attgtgtcag ccttggtgcc tatcattggt
     3061 caccatcttg gtcgaggaaa aaaggaagaa gttgcgtctg atttttacca atttatttat
     3121 ttggccttgg gcctatctgt ggtcttgctg gggatggtac ttttcttggc accaacaatc
     3181 ttgaatcata ttgggttaga agcagcagta gcggcagtag cggttcgcta tctttggttt
     3241 ttatctatcg ggattatccc cttgttgctc tttagcgtca ttcgttcctt gctggattcg
     3301 ctgggcttga ccaaactgtc catgtacctc atgcttttgt tactccctct caatagcgga
     3361 tttaactatc tcttgattta cggtgccttt ggtgttccag aactgggagg ggctggtgct
     3421 ggtttaggaa catccttggc ctactgggtc ttgcttggga tttctgttct ggttttattt
     3481 aaacaggaga agctcaaagc cttacacctt gagaaacgaa ttccacttaa tatggataac
     3541 attaaggaag gagttcgttt aggtctgcct attgggggaa ctgtcttcgc ggaagtggct
     3601 atcttttcag tggttggctt gattatggct aagttttcgt ccttgattat agctagtcac
     3661 cagtcagcta tgaacttttc aagtcttatg tacgcctttc ctatgagtat ctcatcggct
     3721 atggctattg tcgtttccta tgaagtggga gccaagcgat ttgatgatgc gaaaacctat
     3781 attggtctag gaagatggac tgctctcatt tttgcggcct tcaccctaac cttcctttac
     3841 atttttaggg gaaatgtggc cagtctttat ggtaacgacc caaaatttat cgatttgaca
     3901 gcgcgttttt taacttatag tcttttcttc cagttagcag atacctttgc ggcaccgctt
     3961 cagggaattt tgcgggggta taaggataca gttattcctt tttaccttgg tttgcttggt
     4021 tattggggcg tagcaatccc tgtggctacg ctatttgatt ccctaacaga ttttggagct
     4081 tattcttact ggatcggctt gattattagt ttgattgtga gtggggcgct ctaccgttgg
     4141 cgtttaactg tgattatgaa gagatttgaa tctttagcaa aatccaaacg ctaaaaagtt
     4201 tgtgaaaaaa tattcttgac aagaaaatcc cttgttttca cggggttttc ttttttattt
     4261 tgtgaaattt cttttagaaa aactttgaca gtatttgcca aaagcggtaa aatagtaagg
     4321 taagaagaaa gttagaaagg caagaagatg tcaactttag ataaaaatct tttgctagaa
     4381 atgttccgta agatggaaga aatccgtcgc atggacttaa aaattgcaca attagtaaag
     4441 aaagggaaag tgccaggaat gacgcacttt tctgttggtg aagaggcagc taacgtgggg
     4501 gctatgttag ctctcaatcc agatgatctg attacctcaa accaccgtgg acacgggcaa
     4561 gctattgcta aagggattga cctcaacgga atgatggctg aaatccttgg taaatacact
     4621 ggaacctgta aagggaaagg tggatctatg catatcgctg accttgatgc tgggaacctt
     4681 ggtgccaatg gtatcgtagg tggtggtatg gggatcgctg tcggtgcagc cctcagtcag
     4741 caaatgcaaa ataccggtaa aatcgttgtc tgcttctttg gagatggtgc gaccaatgaa
     4801 ggtgttttcc acgaagcagt gaacatggct tctatctgga acctgccagt cattttctat
     4861 tgcattaaca acggttacgg tatctctgcg gatatcaaga aaatgaccaa tatagaacat
     4921 atccatcaac gtagcgccgc ttatggaatt cctggaatgt tcatcgaaga cggtaacaat
     4981 gtcatcgatg tctatgaagg atttcagaaa gctgtagacc atgttcgcag tggcaatggt
     5041 ccagtcttga ttgaaagtgt aacttatcgc tggctcggtc actcatcatc tgaccctggt
     5101 aaatatcgta cgcgtgaaga agtggaattg tggaaacaaa aagatccaat cgaaaacctc
     5161 cgcaattacc ttattgaaaa taacattgca agtgccgaag aattggaaga aatccaagcg
     5221 caagtaaagg aagcagtaga agcttctgtt aaatttgcag aggaaagccc attcccaccg
     5281 cttgaatcag cctttgaaga tatttacgca gactaaggag aaagagataa aatggaaaca
     5341 aaaacaatgt ccttccgtga caccattatc cttgctatgt ctgaggaaat gcgtcgcgat
     5401 gaaaatgtgt tcttgatggg agaagacgtc ggtgtcttcg gaggagactt cggtacttct
     5461 gttggaatgc ttgaagaatt tggtccagaa cgtgtccgtg actgtccgat ttctgaagct
     5521 gccatctctg gagcagcagc aggagcagcc atgacaggac ttcgtccaat cgtcgatatg
     5581 accttcatgg acttctctgt tattgccatg gacaatatcg tcaaccaagc tgctaaaaca
     5641 cgttacatgt ttggtggtaa aggtcaggtt ccaatgactg ttcgttgtgc agctggtaac
     5701 ggagttggct ctgccgccca gcactcacaa tctctagagt cttggtttac tcacattcca
     5761 ggacttaagg ttgtggcacc tggaacacct gcggacatga aaggcctgct taagtcttct
     5821 atccgtgata acaacccagt tattatactt gagtacaagt cagaatttaa ccaaaaaggg
     5881 gaagtgccag ttgatccaga ctacacaatt ccacttgggg ttggtgaaat caaacgccaa
     5941 ggaacggatg taacagttgt tacttatgga aaaatgcttc gccgtgtggt tcaagctgct
     6001 gaagaattag cagaagaagg aatttcagtt gaaattgttg acccacgtac ccttgttccg
     6061 cttgataagg atatcatcat aaactcagtg aagaagactg gtaaggttgt tctggtcaac
     6121 gatgcccaca aaacaagtgg ctatatcggt gaaatttcag ctattatttc agaatcagaa
     6181 gcatttgact atctagatgc accaattcgc cgttgtgcag gagaagatgt gccgatgcct
     6241 tatgcacaaa acctagaaaa tgcaatgatt ccaacagttg aaagtatcaa agatgcaatc
     6301 cgaaaaactt ataacaaaga atagagttac ataagataag ttatgtaaat aaaataaagc
     6361 tgacgagaaa ctttgtatct tttaggtgca gagctcttcg tcattaatat cttagattag
     6421 agcacgggct aaaagctcgg aaaaaagata aatctccttg gcttcatcga agccatcgtc
     6481 gatttcctat ttttcagtcg cttttgacgc cctttgtatc ataaatagaa ttggagaggt
     6541 catggctgat gacaagctaa gagcgactcc tgcagctaga aagttagcgg atgatttagg
     6601 gataaacctc tacgacgttt ctggctcagg tgcaaacggt cgtgtccaca aagaagacgt
     6661 ggaaacttat aaagacacaa acgtggttcg catttcgcca cttgcaaaac gaattgccct
     6721 cgaacataac attgcttggc aggaaatcca aggaaccggt catcgtggta aaatcatgaa
     6781 gaaggatgtt ttggccctgc ttcctgaaaa tatcgaaaac gatagcatca aatctcctgc
     6841 tcagattgaa aaagtggaag aagtccctga taacgtaaca ccatatggtg aaatcgagcg
     6901 tattccaatg acaccaatgc gtaaggttat tgcccaacgc atggttgaat cttacttgac
     6961 tgcgccaacc ttcaccctca actataaagt tgatatgact gaaatgttgg ctcttcgtaa
     7021 gaaggttctt gagccaatca tggaagcaac tgggaagaag actactgtaa cagaccttct
     7081 ttcgcttgca gttgttaaga ctcttatgaa acacccatac atcaatgctt cattgacaga
     7141 agatggcaag actattatca ctcacaacta tgtcaatctt gccatggcag ttgggatgga
     7201 taatggattg atgacacctg ttgtttacaa tgctgagaag atgagtcttt cagaactggt
     7261 tgtagccttt aaggatgtta ttggccgtac cttggatggt aaattggctc caagtgagtt
     7321 acaaaattca acattcacaa tcagtaattt gggaatgttt ggtgttcagt cctttggccc
     7381 gattattaac caacccaact cagctatcct tggtgtcagt tcgacaatcg agaagccagt
     7441 tgtcgtcaat ggtgaaattg tgattcgccc aatcatgagt ttaggattaa ccattgacca
     7501 ccgtgtcgta gatggtatgg ctggtgctaa gtttatgaag gacttgaaag agttgattga
     7561 aaccccaatc tcaatgttga tttaagagca agagtattca tttttaagat atagataaag
     7621 gaaggaagac atggccttag aagtaattat gccaaaagcc ggcgtggata tgacagaagg
     7681 acaaatcgtc caatggaata aaaaagtcgg agaatttgta aaagaaggag aaatcctttt
     7741 ggaaatcatg actgataaag tcagcatgga attggaagcc gaagaagatg ggtacttgat
     7801 tgccattctc aaaggagatg gtgaaactgt ccctgtaacg gaagttatcg gttaccttgg
     7861 tgaagaaagg gaaaacatcc caacagctgg agcagcatcg ccagaagcta gccctgtacc
     7921 tgtagcaagt acctcaaacg atgatggtaa gagcgatgat gcttttgata tcgttgtgat
     7981 tggtggaggt cctgctggtt atgttgcagc cattaaagct gcccaactcg gcggtaaggt
     8041 tgcccttgtt gagaaatctg aacttggtgg aacctgctta aaccgtggat gtattccaac
     8101 caagacctac cttcatagcg ctgaaattat tgaaaatatc ggtcatgctg caaatcgtgg
     8161 tatcgtgatt gaaaatccta acttcactgt tgatatggaa aaacttttag aaactaaatc
     8221 taaagttgtt aatactcttg ttggtggtgt tgcaggactt cttcgtagct acggagttgc
     8281 tgttcataaa ggaattggta caatcactaa agacaagaac gtcttggtaa atggttctga
     8341 attgcttgaa accaagaaaa tcattcttgc tggtggttca aaagtcagca agatcaacgt
     8401 ccctggtatg gaatctccac ttgtcatgac tagtgatgac attcttgaaa tgaacgaagt
     8461 gccagaaagc cttgttatca tcggtggtgg agttgtcggt atcgaactcg gtcaggcctt
     8521 catgacattt ggttcaaaag tgactgttat cgaaatgatg gaccgtatag ttccagctat
     8581 ggatgtggaa gtttctaaga accttcgctt gattcttgag cgtaaaggaa tgaccatctt
     8641 gactggtact aaactgcaag aaatcattga ggaaaatggt caacttcgta tcaaggttga
     8701 aggaaaagac gatatcatcg caagcaaagc tcttctttca attggtcgta tgccagacct
     8761 tgaaggtatt ggagaggttg agtttgaatt ggatcgtggt tgtatcaagg tcaacgaata
     8821 catggaaact tcagttccag gcatttatgc accaggtgac atcaacggta ctaagatgtt
     8881 ggctcacgca gctttccgca tgggtgaagt ttccgctgaa aatgcactta aaggaaatca
     8941 tgcagttgcc aaattgaatt tgactcctgc agccatctac actctccctg aagtagcagc
     9001 agtaggtttg acagaagaac aagcccgtga gaaatacgat gttgccatcg gtaagtttaa
     9061 ctttgctgct aacggtcgtg ctattgcatc tgacgcagct caaggtttcg taaaagttat
     9121 cgctgataag aaatacggag aaatccttgg tgtacacatt attggtcctg cagccgcaga
     9181 attaataaac gaagcatcaa gcatcatcga aatggaaatc actgttgagg aaatgctgaa
     9241 gaccatccac gggcacccaa cttactctga agtgatgtac gaagcgtttg cagatgttct
     9301 aggaatggcc atccattcac ctaagaaaaa ataaaacgaa gatagattag actggaaggt
     9361 tatttccagt ttctatcata taaagtaaag ggatatcatg aaatacatta tcaatcattc
     9421 aaatgacact gcttttaata ttgccttgga agaatacgcc tttaaacacc ttttggatga
     9481 ggatcaaatc ttcctacttt ggattaacaa gccatctatc attgttggtc gtcaccagaa
     9541 cactatcgaa gaaatcaacc gtgattatgt tcgcgaaaat ggtattgagg tagttcgccg
     9601 tattagtggt ggtggagctg tttaccacga tttaaataac ctcaactaca cgatcatctc
     9661 caaagaagat gaaaataagg catttgactt caagagcttc tcaactccgg ttatcaatac
     9721 cctggctcaa cttggggtta aagctgagtt cacaggtcgt aatgaccttg agattgatgg
     9781 taagaagttc tgtggcaatg cccaagccta tatcaacggc cgtatcatgc accacggttg
     9841 cttgctcttt gacgttgatt tgtcagtcct cgcaaatgcc cttaaggttt caaaagataa
     9901 atttgaatca aaaggtgtga aatccgtccg tgcccgtgta accaatatta tcaatgaatt
     9961 accaaaaaaa atcacagtcg aaaaattccg tgatttactc ttggaataca tgaaaaaaga
    10021 gtacccagag atgactgaat acgtcttttc agaagaagaa ttggccaaaa tcaatcacat
    10081 caaggatact aagtttggaa cttgggactg gaactatggt aaatcacctg aatttaacgt
    10141 ccgtcgtgga accaaattca ctagtggtaa ggttgaagtc tttgctaacg ttactgaatc
    10201 aaaaatccaa gacatcaaga tttatggtga cttctttggt attgaagacg ttgctgcagt
    10261 agaagatgtc cttcgtgggg tgaaatacga acgcgaagat gttcttaagg cgctaaaaac
    10321 cattgatatc acacgctact tcgctggtat tagccgtgaa gaaatcgctg aagcggtagt
    10381 tggataaatc aaaaagaagt tggccaacta accaacttct ttttttgata tttatttaca
    10441 taatttaaaa tacgtaaaat tataaactat ctagagcatt cttttgttca tcattaacaa
    10501 tatgggtata gaggtcagtg acttgtgtgc tggcatgtcc tagttggtga ctgactaaaa
    10561 cttgtgattt agtcgcatca tagagcctag ttgctagcgt atggcgcagt ttatggggtg
    10621 ttacacgcac tttaaaatcc tctgagtatt tagcaaccat tttctcaacg ctagaagcat
    10681 cgatacgatt aggaacacct ctgtagagag ttaaaaaaag ggctgtatct gttttttccg
    10741 ttttatagcg ttgattccga atggccagat aattctctaa ataaggttta gcaaaagcag
    10801 cgacattgac tgagtcacgt ttgccacctt ttcgagtaac atcaataacc atcattttta
    10861 gattgagatc tcttagatct agattaacag cttcagataa gcgaacacca gatgccaaga
    10921 gaagggcaat aatggctaaa tctcgttctt tatttttgtt gaatgatgag agagctcgat
    10981 ttgaaagctg ttgtgggtgc tcttgatcga tataagttag aaaaccttct gtttcatcac
    11041 ctagaaagag tttttgcttg atattttcag ctctggcagc aagggtttct ttctttttct
    11101 tggttgaaac ttttttcatt acattacgat agaaataagg ttccccctga tcgttttcaa
    11161 cctcctcggt tagatacttg taaagactag aaagtgctga taaggttcga ttgatagttg
    11221 tctgtgaaac accctgtttt gttgtattag cattcagcaa gggacgttca cgtagataaa
    11281 ggataaagga ttccatgtct ttcttagaca tattttccaa aactgataaa ggaatatcgg
    11341 atattttatc agcgtttgaa ataccagact ccaaaaccca gctgaaaaat cggtcatatt
    11401 ccttaaggta ttcgtacagg gttgtaaaac tgtagggtac agccagctta gattggtagt
    11461 attccagaac ataccagggc atgagttgtt ttagtttgtc gattcgttcc agtaaaatct
    11521 cacgtttcat gtattttctc cataagtaag tatactagta gtatagcata gacttgtata
    11581 tttttcaaga aaattatagt ttttcagaaa gatgttatag gagtttttca aagtgataaa
    11641 aagacttaga cctacaaaca aaacagaata aggaaaataa taaaaatctc acccactaaa
    11701 cttctgttaa tactacatag ctagaaattg atttgattgt cctgattgtt ttatcctatt
    11761 tctatttcat ttcactatat aattgctat
//
LOCUS       DAVHIZ010000051        11335 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.053, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000051 DAVHIZ010000000
VERSION     DAVHIZ010000051.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11335)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11335)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11335
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.053"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            182..2110
                     /gene="glgB"
                     /locus_tag="VVO18_001648"
     CDS             182..2110
                     /gene="glgB"
                     /locus_tag="VVO18_001648"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398622.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="1,4-alpha-glucan branching protein GlgB"
                     /protein_id="HEU5586763.1"
                     /translation="MDNREALKTFMTGENFYLQHYLGAHREELNGEYGYTFRVWAPNA
                     QAVHLVGDFTNWIENQIPMVRNDFGVWEVFTNMAQEGHIYKYHVTRQNGHQLMKIDPF
                     AVRYEARPGTGAILTELPEKKWKDGLWLARRKRWGFEERPVNIYEVHAGSWKRNSDGS
                     PYSFAQLKDELIPYLVEMNYTHIEFMPLMSHPLGLSWGYQLMGYFALEHAYGRPEEFQ
                     DFVEECHTHNIGVIVDWVPGHFTINDDALAYYDGTPTFEYQDHNKAHNHGWGALNFDL
                     GKNEVQSFLISCIKHWIDVYHLDGIRVDAVSNMLYLDYDDAPWTPNKDGGNLNYEGYY
                     FLQRLNEVIKLEYPDVMMIAEESSSATKITGMKEIGGLGFDYKWNMGWMNDILRFYEE
                     DPIYRKYDFNLVTFSFMYVFKENYLLPFSHDEVVHGKKSMMHKMWGDRYNQFAGLRNL
                     YTYQICHPGKKLLFMGSEYGQFLEWKSEEQLEWSNLEDPMNAKMKYFASQLNQFYKDH
                     RCLWEIDTSYDGIEIIDADNRDQSVLSFIRKGKKGEMLVCIFNMVPVERKDFTIGLPV
                     AGIYEEVWNTELEEWGGVWKEHNQTVQTQEGLWKDYEQTLTFTLPAMGASVWKIKRRL
                     KSTKTVTNKNQKGVENEK"
     gene            2100..3242
                     /locus_tag="VVO18_001649"
     CDS             2100..3242
                     /locus_tag="VVO18_001649"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000787267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase"
                     /protein_id="HEU5586764.1"
                     /translation="MKNEMLALILAGGQGTRLGKLTQSIAKPAVQFGGRYRIIDFALS
                     NCANSGIHNVGVVTQYQPLALNNHIGNGSSWGLDGINSGVSILQPYSASEGNRWFEGT
                     SHAIYQNIDYIDSVNPEYVLILSGDHIYKMDYDDMLQSHKDNNASLTVAVLDVPLKEA
                     SRFGIMNTDANNRIVEFEEKPAQPKSTKASMGIYIFDWQRLRNMLVAAEKSKVGMSDF
                     GKNVIPNYLESGESVYAYEFSGYWKDVGTIESLWEANMEYISPENALDSRNRQWKIYS
                     RNLISPPNFLGANAHVEDSLVVDGCFVDGTVKHSILSTGAQVREGAEVLDSVIMSGAI
                     IGQGAKIKRAIIGEGAIISDGVEIDGTDEVQVVGYNEVVGVATDED"
     gene            3232..4371
                     /gene="glgD"
                     /locus_tag="VVO18_001650"
     CDS             3232..4371
                     /gene="glgD"
                     /locus_tag="VVO18_001650"
                     /EC_number="2.7.7.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate adenylyltransferase subunit
                     GlgD"
                     /protein_id="HEU5586765.1"
                     /translation="MKIDKYSAILGNTVGFHNMSTLTDHRPVASLPFGGKYRLIDFPL
                     SSLANAGVRSVFGIFQQDNISSVFDHIRSGREWGLSTLLSHYYLGIYNTRVESSTVGK
                     EYYQQLLTYLKRSGSNQTVALNCDVLINIDLNQVFHLHSTTKEPITVVYKKLAKKDIS
                     EVNAILDVDETDHVLSHKLFDSKSTAETFNMSTDIFVVDTPWLIEHLEEEAKKEHPEK
                     LRYVLRDLAVKEGAFAYEYTGYLANIHSVKSYYQANIDMLESQKFYSLFSPNQKIYTK
                     VKNEEPTYYANTSKVSTSQFASGSIIEGQVANSVLSRNIHVHKDSLVKDSLLFPRVVI
                     GEGAQVEYAILDKGVEVEPGVVIRGTAEHPVVVKKGAKVTEDIHS"
     gene            4368..5801
                     /gene="glgA"
                     /locus_tag="VVO18_001651"
     CDS             4368..5801
                     /gene="glgA"
                     /locus_tag="VVO18_001651"
                     /EC_number="2.4.1.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000697278.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycogen synthase GlgA"
                     /protein_id="HEU5586766.1"
                     /translation="MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYY
                     DMVEAKFGSQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDF
                     DDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVL
                     TIHNLEFQGQFSEGMLGDLFGVGFERYADGTLRWNNCLNWMKAGILYANRVSTVSPSY
                     AHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAK
                     NKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPA
                     FEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGT
                     LPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNL
                     QKQAMESDFSWDTACKSYLDLYHSLVN"
     gene            5860..6231
                     /locus_tag="VVO18_001652"
     CDS             5860..6231
                     /locus_tag="VVO18_001652"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809343.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD-IB family phosphatase"
                     /protein_id="HEU5586767.1"
                     /translation="MSQVKGLCVLDVDGTLILEEVIDLLGREAGHEAEISQITSRAMR
                     GELVFESSLRKRVSLLEGLPILVFDNVFNSIHLSLNVPEFISILQKNGILVGLVSGGF
                     TPIVGEISKIPWYCLFHCQPA"
     gene            6176..6400
                     /locus_tag="VVO18_001653"
     CDS             6176..6400
                     /locus_tag="VVO18_001653"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAD family hydrolase"
                     /protein_id="HEU5586768.1"
                     /translation="MERLAKSLGIAYFTANQLEVKEGLLTGKLVGQIISPQVKKETLE
                     KWRKKLKLSKERTVAIGDGVNNLLMLKSAE"
     gene            6514..7629
                     /locus_tag="VVO18_001654"
     CDS             6514..7629
                     /locus_tag="VVO18_001654"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000706318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerate kinase"
                     /protein_id="HEU5586769.1"
                     /translation="MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDG
                     GEGTVDAIRHSLDLKEKWIQVTDPFGQKEAMRYFQKGELALFEVADLVGLGKIPLEKR
                     NPLQIQTCGIGELILHLISKGIKDIYIGVGGTASNDGGLGIAAGLGYQFYDRDGNVLP
                     ASGQSLLNLASVSTENCYKIPEGVQIHILADVVSPLCGHQGATYTFGNQKGLHPTMFA
                     VVDQAIQDFYEKFSPATLEIKGAGAGGGLAGGLCAFAQASIVSGIDTCLDLINFDKKV
                     SDADLVVVGEGRLDSQSFAGKAPIGVAKRTPVGVPVIAICGSLAEDLPPLPFENIQAV
                     FSILEKSEPLEDSLKNASLYLERTAANIGHLLNMCKI"
     gene            complement(7626..8072)
                     /locus_tag="VVO18_001655"
     CDS             complement(7626..8072)
                     /locus_tag="VVO18_001655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YueI family protein"
                     /protein_id="HEU5586770.1"
                     /translation="MTDLSKQLLEKAHGGLKINPDEQRRYLGTFEERVLGYVDIDTAN
                     SPQLEKGFLFILENLQEKAEPLFVKISPTIEFDKQVFYLKEAKETDSQATIVSEEHIT
                     SPFGLVIHSNAPVQVEEKDLRLAFPKIWEVKKEEPAKTSLWKKWFS"
     gene            8236..9540
                     /gene="eno"
                     /locus_tag="VVO18_001656"
     CDS             8236..9540
                     /gene="eno"
                     /locus_tag="VVO18_001656"
                     /EC_number="4.2.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985288.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphopyruvate hydratase"
                     /protein_id="HEU5586771.1"
                     /translation="MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTG
                     EHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPN
                     KGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPI
                     AFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDG
                     VETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQID
                     YLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQE
                     GAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQ
                     IKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK"
     gene            complement(9678..9815)
                     /locus_tag="VVO18_001657"
     CDS             complement(9678..9815)
                     /locus_tag="VVO18_001657"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="HEU5586772.1"
                     /translation="MPLKTITDRVGHSESEVTTSIYTHVTKNMKDEAINVLDKVMKKI
                     F"
     gene            complement(9856..11112)
                     /locus_tag="VVO18_001658"
                     /pseudo
     CDS             complement(9856..11112)
                     /locus_tag="VVO18_001658"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(11236..11335)
                     /locus_tag="VVO18_001659"
                     /pseudo
     CDS             complement(11236..11335)
                     /locus_tag="VVO18_001659"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         3393 a         1979 c         2495 g         3468 t
ORIGIN      
        1 tagaaaaaga aaggcgtttt cgcaattttt ttgaaaaaaa tactgattta caattgaacg
       61 agtaagtgaa cttgttgtag attttcaaaa taattaaaga agtatagtaa tttacttgaa
      121 tcttctctaa aaaggtagta taataaaaac atagaaaacg cttacaggag aaagggagta
      181 tatggataat agagaagcat taaaaacctt tatgacgggt gaaaattttt atctccaaca
      241 ttatctagga gcacataggg aagaactaaa tggagagtat ggctatacct tccgtgtttg
      301 ggcacctaat gctcaggctg ttcacttggt tggtgatttt accaactgga ttgaaaatca
      361 gattccaatg gtaagaaatg actttggggt ctgggaagtc tttaccaata tggctcaaga
      421 agggcatatt tacaaatatc atgtcacacg tcaaaatggt catcaactga tgaagattga
      481 cccttttgcc gtcaggtatg aggctcgtcc aggaacaggg gcaatcttaa cagagcttcc
      541 tgagaagaaa tggaaggatg gactttggct ggcacgaaga aaacgttggg gctttgaaga
      601 gcgtcctgtc aatatttatg aagttcacgc tggatcatgg aaaagaaatt ctgatggcag
      661 tccttatagt tttgcccagc tcaaggatga actcattcct tatctcgttg aaatgaacta
      721 tactcatatt gagtttatgc ccttgatgtc ccatcctttg ggcttgagtt gggggtatca
      781 gcttatgggt tacttcgctt tagagcatgc ttatggccga ccagaggagt ttcaagattt
      841 tgtcgaggag tgtcataccc ataatattgg ggttattgtg gactgggtac caggtcactt
      901 taccatcaac gatgatgcct tagcctatta tgatgggaca ccgacttttg aataccaaga
      961 ccataataag gctcataacc atggttgggg tgcccttaat tttgaccttg gaaaaaatga
     1021 agtccagtcc ttcttaattt cttgcattaa gcattggatt gatgtctatc atttggatgg
     1081 tattcgtgtg gatgctgtta gcaacatgct ctatttggac tatgatgatg ctccatggac
     1141 acctaataaa gatggcggaa atctcaacta tgaaggttat tatttccttc agcgcttgaa
     1201 tgaggttatt aagttagaat atccagatgt gatgatgatt gcagaagaaa gttcgtctgc
     1261 gaccaagatt acgggaatga aagagattgg tggtctagga tttgactaca aatggaacat
     1321 gggctggatg aatgatatcc tccgtttcta cgaagaagat ccgatctatc gtaaatatga
     1381 ctttaacctg gtgactttca gctttatgta tgttttcaag gagaattatc tcttgccatt
     1441 ctcgcacgat gaagtggttc atggcaagaa gagtatgatg cataagatgt ggggagatcg
     1501 ttacaatcaa tttgcaggct tgcgcaatct ctatacgtac caaatttgtc accctggtaa
     1561 gaaattgctc ttcatgggta gcgaatacgg tcaattccta gaatggaaat ctgaagaaca
     1621 gttggaatgg tctaacctag aagacccaat gaatgctaag atgaagtatt tcgcttctca
     1681 gctaaaccag ttttacaaag atcatcgctg tctgtgggaa attgatacca gctatgatgg
     1741 tattgaaatc attgatgcgg ataatcgaga ccagagtgtt ctttccttta ttcgtaaggg
     1801 taaaaaggga gaaatgttag tctgtatctt taatatggta cctgttgagc ggaaagattt
     1861 tacaatcgga ctacccgttg caggaattta cgaagaagta tggaatactg agttggaaga
     1921 gtggggaggc gtttggaaag aacataatca aactgttcaa acgcaagaag gactatggaa
     1981 agattatgag cagaccttaa cctttaccct accggctatg ggagcaagtg tatggaaaat
     2041 caaacgtcgc ttgaaatcta ctaaaaccgt cacaaataaa aaccaaaaag gagtagaaaa
     2101 tgaaaaatga aatgttagct ttgattcttg ctggtgggca aggaactcgt ctcggtaaac
     2161 tcactcaaag catcgcaaaa ccagctgtgc aatttggtgg gcgctaccgt atcattgact
     2221 ttgccctatc aaactgtgcc aactcaggga ttcacaatgt tggggtcgtt acacagtatc
     2281 aaccacttgc tctcaacaac catattggga atggttcaag ctggggacta gacggtatta
     2341 attcaggtgt ctctattctt caaccttatt ctgcaagtga aggaaatcgt tggtttgagg
     2401 ggactagtca cgctatttac caaaatatcg actatatcga cagtgtcaat cctgagtatg
     2461 tcttgatttt gtctggggat cacatctaca aaatggacta tgatgatatg ctccagtctc
     2521 ataaggataa taatgccagc ttgacagtag cagttttaga cgtccctctt aaagaagcaa
     2581 gccgttttgg tatcatgaac acagatgcta acaatcgtat tgttgaattt gaagaaaaac
     2641 cagctcaacc taaatctaca aaagcttcta tgggaatcta catttttgat tggcaacgcc
     2701 ttcgtaatat gttagtcgct gctgaaaaga gcaaggttgg catgtcagac tttggtaaaa
     2761 atgtcattcc aaattacctt gagtcaggtg aaagtgttta tgcttacgaa tttagtggtt
     2821 attggaaaga tgttggtact attgagtcac tttgggaagc gaacatggag tatatttctc
     2881 cagaaaatgc cttggatagt cgtaaccgtc aatggaagat ttactcaaga aacttgattt
     2941 caccaccaaa cttcctcggg gcaaatgctc atgtggaaga ctcattagtt gtagacggat
     3001 gtttcgttga tggaactgtt aaacattcta tcctttcaac aggcgcgcaa gttcgcgaag
     3061 gagcggaagt ccttgattca gttatcatga gtggagctat cattggtcaa ggagctaaga
     3121 ttaaacgtgc cattattggt gaaggtgcga ttatttctga cggtgtcgaa attgatggaa
     3181 cagatgaagt acaagttgta ggatataatg aagtagtggg ggtagcaaca gatgaagatt
     3241 gataaatatt ctgccatttt aggaaataca gttggttttc acaatatgtc gacattgacg
     3301 gaccaccgtc cagtagcaag tttgccattt ggtgggaaat atcgtttgat tgacttccca
     3361 ctttcaagcc ttgctaatgc aggtgttcgt agtgtctttg gtattttcca gcaggataat
     3421 atcagctcag tatttgacca tattcgttca ggacgcgagt ggggcttatc aacccttctt
     3481 agccattact atctaggaat ttacaatacc cgtgtagaaa gtagtacagt tggaaaagaa
     3541 tactaccaac agcttcttac ttatttgaaa cgttctggct caaaccaaac ggttgccctc
     3601 aactgcgatg ttcttattaa cattgatttg aaccaagttt tccacctaca tagtacaaca
     3661 aaagagccta tcactgtagt ttataaaaaa ctagctaaga aagatatttc agaagtaaat
     3721 gcaatcttgg atgtagatga aacagaccat gttctttctc ataaactctt tgatagcaag
     3781 tcaacagctg aaacgttcaa tatgtctaca gatatctttg tcgttgatac accttggttg
     3841 attgaacact tggaagaaga agctaaaaaa gaacatccag agaaattgcg ctatgtttta
     3901 cgggatttgg ctgtaaaaga gggagctttc gcctacgagt acacgggcta tctagccaat
     3961 attcactctg ttaaatctta ttatcaagcg aatatcgata tgcttgaatc acaaaaattc
     4021 tattctcttt tctcaccaaa ccaaaagatt tatacaaagg tcaaaaacga agagccaact
     4081 tactatgcta atacatctaa ggtaagcact tctcagtttg cctctggtag tattattgaa
     4141 ggtcaagtag ctaattctgt tctatcacgt aatattcatg tccataagga tagcttggtt
     4201 aaagatagcc tgctcttccc tcgtgttgtt attggagaag gggctcaggt cgaatatgct
     4261 atcttggaca aaggggttga agttgagcct ggtgttgtga ttcgaggaac tgcagaacat
     4321 ccagttgtgg ttaagaaagg tgctaaagta acagaggata ttcattcatg aaaattttat
     4381 ttgtagcagc agagggtgca cccttttcaa aaacaggtgg tttgggagac gtcattggcg
     4441 ctcttccaaa atcactggta aaagctgggc acgaagttgc agtgatttta ccctactatg
     4501 atatggtaga ggctaaattt ggaagtcaga ttgaagatgt gcttcatttt gaggtgagcg
     4561 ttggttggcg cagacagtat tgtggaatta agaaaacagt attaaatggt gtaaccttct
     4621 actttattga caatcaatat tatttcttcc gtggtcatgt ttacggtgat tttgatgacg
     4681 gagaacgctt tgcctttttc caactggctg ccattgaggc tatggaaagg attgacttta
     4741 ttcctgatct tctccatgtt catgactacc atacagctat gattcctttc ttgttgaagg
     4801 aaaaataccg ttggattcaa gcctatgagg acattgaaac agttttaacc attcataatt
     4861 tagaattcca aggacaattt tcagaaggaa tgttgggtga tttgtttgga gttggctttg
     4921 aacgttacgc tgatggcacc cttcgatgga acaactgtct gaactggatg aaggcaggta
     4981 ttctctatgc gaaccgtgtt tcaactgttt cacctagcta tgctcatgaa attatgacta
     5041 gtcagtttgg atgtaatttg gatcagattc ttaaaatgga gtctggtaaa gtatctggta
     5101 tcgtgaatgg gattgatgct gatctttata atcctcagac ggatgctctt ttagactatc
     5161 atttcaatca ggaagatttg tctgggaaag ccaaaaataa ggcaaaattg caagaaagag
     5221 ttggcttgcc tgttagagca gacgttccac tggtgggaat tgtttctcgt ttgacacgtc
     5281 aaaaaggttt tgatgtggtg gtcgaaagtc ttcaccatat cttgcaagaa gatgttcaga
     5341 ttgttctttt gggaactggc gatccagcct ttgaaggagc tttctcatgg tttgctcaga
     5401 tttacccaga caagctatca acaaatatca cttttgatgt caaacttgct caggaaatct
     5461 acgctgcttg tgacctcttc ctcatgccaa gtcgttttga accgtgtggc ttgtctcaaa
     5521 tgatggctat gcgttatgga accttgccat tggtccatga agttggaggc ttgcgagata
     5581 cagttcgcgc tttcaatcca atcgaaggaa gcggtactgg ctttagcttt gacaatctat
     5641 ctccttattg gttaaattgg actttccaaa cagcattgga cttgtataga aaccatccag
     5701 acatttggag aaacctacaa aaacaagcta tggagagtga cttctcatgg gatacagcct
     5761 gcaagtcata ccttgacttg taccatagtt tagttaatta atagataaaa tcgtatgatg
     5821 acttcatacg atttttaggc tgtttagaga ggagaactga tgtctcaagt aaaaggcttg
     5881 tgtgttttgg atgtagatgg aaccttaatc ctagaagaag tgattgatct tttagggaga
     5941 gaggcaggtc atgaggcgga aatttcgcag attacaagtc gagcaatgcg aggagagttg
     6001 gtctttgaaa gcagtttaag aaaaagagtg tccttgttgg aaggtcttcc tattttggtc
     6061 tttgataacg tcttcaactc aattcatcta tcgctaaatg tcccagagtt catctctatt
     6121 ctccaaaaga atggcatcct agttggtctg gtgtctggtg gatttacacc aatagttgga
     6181 gagattagca aaatcccttg gtattgccta tttcactgcc aaccagcttg aagtcaaaga
     6241 aggtctttta acaggaaaat tagttggaca aattataagt ccccaggtca aaaaagaaac
     6301 tctggaaaaa tggagaaaga aactaaaact ttctaaagaa agaacggtgg caatcggtga
     6361 tggggtcaat aatctattaa tgttgaagtc ggcggagtga ggaatcgcct tttgttccaa
     6421 agaaatgctc aaaaaagaaa taccacatca tgttgacaag agggattttt tagaagttct
     6481 tcctttgatt gactgtttag aatgagggaa aatatgaaga ttgtaattgc accggattcg
     6541 tttaaggaaa gcttgacagc tcaacaggta gctgaagcaa taaaaagagg cttccaacaa
     6601 tcgatagcag atgtagaatg tctcctctgc cctgttggtg atgggggaga aggtactgta
     6661 gatgctatcc gacattctct tgacctaaaa gaaaaatgga tccaagtgac agaccctttt
     6721 ggacaaaaag aagccatgcg ctattttcaa aaaggggaac tggcactatt tgaagtagct
     6781 gacttggttg gtcttggaaa aattccgcta gagaaacgaa atccacttca aatccaaact
     6841 tgtggtattg gagagttgat tctccatctc atttctaaag ggattaaaga tatttatatc
     6901 ggtgttggtg gcacggccag taatgatgga ggactgggga ttgctgctgg tttaggttat
     6961 caattttatg atagggatgg aaatgtcttg cctgcttccg gtcaatcctt attaaactta
     7021 gcttctgttt caacagaaaa ttgctataaa attcctgaag gtgttcaaat tcatattcta
     7081 gcagatgtcg tgagtccctt atgtggtcat caaggtgcga cttacacttt tggcaatcaa
     7141 aaaggtctac atccgactat gtttgcagtc gtagatcagg cgatccaaga tttttatgaa
     7201 aaattctcac ctgcaacatt agaaattaaa ggagcaggag caggtggagg ccttgctggt
     7261 ggtttgtgtg cctttgctca ggcaagtatc gtgtctggaa ttgatacctg cttggactta
     7321 atcaactttg ataagaaagt ttcagatgct gacttggttg ttgttggaga aggaagactt
     7381 gatagtcaaa gctttgctgg gaaagcgcct ataggtgttg caaaaagaac ccctgttgga
     7441 gttcctgtta ttgctatttg cggtagtctt gctgaagatt tacctcccct accatttgaa
     7501 aatatccaag ctgtcttttc tattttggag aaaagtgaac ctttagaaga tagtttgaaa
     7561 aatgccagtc tctatctgga gcgcacggct gccaatattg ggcacttatt aaatatgtgc
     7621 aagatttagc taaaccattt cttccataag gatgttttgg ctggttcttc ctttttaact
     7681 tcccaaattt ttggaaaagc aagtcgaagg tctttttctt ctacttgaac tggtgcattg
     7741 ctatgaataa ccaggccgaa aggagaagta atatgctctt cagatactat ggtggcttga
     7801 ctatcagttt cttttgcttc ttttaagtag aaaacttgct tatcaaattc gatagttggt
     7861 gaaatcttca caaatagtgg ctctgctttt tcctgaaggt tttctaaaat aaataaaaag
     7921 cctttttcta actgagggct atttgctgtg tcaatatcta catatccaag aactctttcc
     7981 tcaaaagtac caagatagcg tctttgctca tccggattta tttttaaccc accatgagct
     8041 ttttcaagta attgttttga taaatctgtc atgaaaacag tatatcataa aagttagaat
     8101 aaaacagaca aaagaaagcg attactttat aaagttaagg aaaagttgca caaagataac
     8161 gttttttctt gaaaaaggag gggttttaag gtattataga ggtgtaaaaa atttaactca
     8221 taaggagagt aaaaaatgtc aattattact gatgtttacg ctcgcgaagt cctagactca
     8281 cgcggtaatc caacacttga agtagaagtt tacactgaat caggtgcttt cggacgtggt
     8341 atggttccat caggagcttc tactggtgaa cacgaagcag ttgaacttcg cgacggtgac
     8401 aaatctcgtt acggtggtct tggtacacaa aaagctgttg acaacgtaaa caacatcatt
     8461 gctgaagcta tcattggcta cgatgtacgt gatcaacaag ctattgaccg tgctatgatc
     8521 gcacttgacg gtactcctaa caaaggtaaa ttgggtgcga atgcaatcct cggtgtgtct
     8581 atcgctgtag ctcgtgctgc tgctgactac cttgaaatcc cactttacag ctatcttggt
     8641 ggattcaaca ctaaagttct tccaactcca atgatgaaca tcatcaacgg tggttctcac
     8701 tctgacgctc caatcgcttt ccaagagttc atgatcttgc cagttggtgc gccaacattt
     8761 aaagaagccc ttcgttacgg tgctgaaatc ttccacgctc ttaagaaaat ccttaaatca
     8821 cgtggtttgg aaactgccgt aggtgacgaa ggtggattcg ctcctcgttt cgaaggaact
     8881 gaagatggtg ttgaaactat ccttgctgcg attgaagctg ctggatatgt accaggtaaa
     8941 gacgtattta tcggatttga ctgtgcttca tcagaattct acgataaaga acgtaaagtt
     9001 tacgactaca ctaaatttga aggtgaaggt gctgctgttc gtacatctgc agaacaaatc
     9061 gactaccttg aagaattggt taacaaatac ccaatcatca ctattgaaga tggtatggat
     9121 gaaaatgact gggatggttg gaaagctctt actgaacgtc ttggtaagaa agtacaactt
     9181 gttggtgacg acttcttcgt aacaaacact gactaccttg cacgtggtat ccaagaaggt
     9241 gctgctaact caatccttat caaagttaac caaatcggta ctcttactga aacttttgaa
     9301 gctatcgaaa tggctaaaga agctggttac actgctgttg tatcacaccg ttcaggtgaa
     9361 actgaagatt caacaatcgc tgatattgca gttgcaacta acgcaggaca aatcaagact
     9421 ggttcacttt cacgtacaga ccgcatcgct aaatacaacc aattgcttcg tatcgaagac
     9481 caacttggtg aagtagctga atatcgtgga ttgaaatcat tctacaacct taaaaaataa
     9541 aatagttcag tgaactattt tatcccgaac catgaaattc aaaagttcgg ccgttgattt
     9601 aacaacgttt ctagcccctc ggattttatc cgaagggcta tttttgtatt tagaggacaa
     9661 aaaagggaca aaacttttta aaaaatcttt ttcataactt tatccagtac attgattgct
     9721 tcatctttca tgttctttgt gacgtgggtg tagatggaag tagtgacttc agattcggaa
     9781 tgaccaaccc tgtccgtgat tgtttttaaa ggaattttat tggctctttg tcaactgtag
     9841 tgggttgaag aaaagctaag cttgagaaag gacaaatttt gtcctttctt ttttgatatt
     9901 cagggcgata aaaatccgtt ttttgaagtt ttcaaagttt cgaaaaccaa aggcattgcg
     9961 cttgataagt ttgatgagat tattggtcgc ttccagtttg gcattagaat agtgtagttg
    10021 aagggcgttg acaatctttt ctttatcttt gaggaaggtt ttaaagacag tctgaaaaat
    10081 aggatgaacc tgcttaagat tgtcctcaat aagtccgaaa aatttctctg gttccttatt
    10141 ctggaagtga aacagcaaga gctgatagag ctgatagtgg tgtttcaagt cttgtgaata
    10201 actcaaaagc ttgtttaaaa tctctttatt ggttaagtgc atacgaaaag taggacgata
    10261 aaatcactta tcactcagtt tacggctatc ctgttgaatg agtttccagt agcgcttgat
    10321 agccttgtat tcatgggatt ttcgatgaaa ctgattcatg atttggacac gcacacgact
    10381 catagcacgg ctaagatgtt gtacaatgtg aaagcgatcc aacacgattt tagcacatgg
    10441 gaaaagttgt ctagctaagt catagtaagg actaaacata tccatagtaa tgattttgac
    10501 gcgacatcgg acggctctat catatttaag aaagtgattt cggatgacag cttgtgttct
    10561 tcccttaaga acagtgatga tattgagatt gttaaaatct tgcgcaatga agctcatctt
    10621 tccttttgta aaagcatact catcccaaga cataatctca ggaagacaag aaaaatcatg
    10681 tttaaagtgg aagtcattga gctttcgaat gacagttgaa gttgagatgg aaagctgatg
    10741 ggcaatatca gtcatagaaa tcttttcaat taacttttga gcaatctttt ggttgatgat
    10801 acgagggatt tggtgattct tcttgacgat agaagtttca gcgaccatca tttttgaaca
    10861 gtgatagcac ttgaatcgac gctttctaag gagaattcta gtaggcatac cagtcgtttc
    10921 aagataagga attttagaag gtttttgaaa gtcatatttc ttcaattggt ttccgcactc
    10981 agggcaagat ggggcgtcgt agtccagttt ggcgatgatt tccttgtgtg tatccatatt
    11041 gatgatatct agaatcttga tgtttgggtc tttaatgtct agtaattttg tgataaaatg
    11101 taattgttcc atatgattct ttctaatgag ttgttttgtc gcttttcatt ataggtcata
    11161 tgggactttt tttctacaat aaaataggct ccataatatc catagggggg ttacccacta
    11221 caaatattat agagtctcaa taggattgtg ctcaggtgag tagggaggaa gaggtaaaaa
    11281 tttatgccca aactcttcac acaagagttc tagcttcccc attctatgga atctt
//
LOCUS       DAVHIZ010000052        11264 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.054, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000052 DAVHIZ010000000
VERSION     DAVHIZ010000052.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11264)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11264)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11264
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.054"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(129..2630)
                     /locus_tag="VVO18_001660"
     CDS             complement(129..2630)
                     /locus_tag="VVO18_001660"
                     /EC_number="6.1.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014639013.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="leucine--tRNA ligase"
                     /protein_id="HEU5586773.1"
                     /translation="MSFYNHKEIEPKWQGYWAEHHTFKTGTDASKPKFYALDMFPYPS
                     GAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTA
                     ENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE
                     ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWSESIKD
                     MQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSSEQ
                     AEAVADYKHQASLKSDLVRTDLAKEKTGVWTGAYAINPVNGKEMPIWIADYVLASYGT
                     GAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLDGLNKEDA
                     IAKIVAYLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPETELPLV
                     LPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPH
                     NTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFN
                     QGMILGTSYRDHRGALVTTDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDV
                     VEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALD
                     KAYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDKLYIDYAKGFIQLIAPFAPHL
                     AEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREEL
                     QEIALADEKVKAEIDGKEIVKVIAVPNKLVNIVVK"
     gene            complement(3085..4173)
                     /locus_tag="VVO18_001661"
     CDS             complement(3085..4173)
                     /locus_tag="VVO18_001661"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol dehydrogenase"
                     /protein_id="HEU5586774.1"
                     /translation="MRIFASPSRYIQGENALFENAKSILDLGNYPILLCDQLVYDIVG
                     KRFEDYLHRYGFHIVLALFNGEASDNEINRVVALAEKENCDSIIGLGGGKTIDSAKAI
                     ADLIEKPVIIAPTIASTDAPVSALSVIYTDEGAFDHYLFYSKNPDLVLVDTKVISQAP
                     KRLLASGIADGLATWVEARAVMQANGKTMLGQQQTLAGVAIAKKCEETLFADGLQAMA
                     ACEAKVVTPALENIVEANTLLSGLGFESGGLAAAHAIHNGFTALTGDIHHLTHGEKVA
                     YGTLVQLLLENRPKEELDKYIEFYKKIGMPTTLKEMHLDQVGYDDLIKVGKQATMEGE
                     TIHQMPFKISPSDVAQAIIAVDAYVNSK"
     gene            complement(4191..4859)
                     /locus_tag="VVO18_001662"
     CDS             complement(4191..4859)
                     /locus_tag="VVO18_001662"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000395441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fructose-6-phosphate aldolase"
                     /protein_id="HEU5586775.1"
                     /translation="MEFMLDTLNLDEIKKWSEILPLAGVTSNPTIAKREGSINFFERI
                     KDVRELIGSTPSIHVQVISQDFEGILKDAHEIRRQAGDDIFIKVPVTPAGLRAIKVLK
                     KEGYHITATAIYTVIQGLLAIEAGADYLAPYYNRMENLNIDSNSVIRQLALAIDRQNS
                     PSKILAASFKNVAQVNNALAAGAHAVTAGADVFESAFAMPSIQKAVDDFSDDWFVTQN
                     SRSI"
     gene            complement(4878..7316)
                     /locus_tag="VVO18_001663"
     CDS             complement(4878..7316)
                     /locus_tag="VVO18_001663"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000248319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl radical protein"
                     /protein_id="HEU5586776.1"
                     /translation="MVNTEVARTTIKTEYFGSLTERMNKYREDVLNKKPYIDAERAVL
                     ATRAYERYKEQPNVLKRAYMLKEILENMSIYIEEESMIAGNQASSNKDAPIFPEYTLE
                     FVLNELDLFEKRDGDVFYITEETKEQLRSIAPFWENNNLRARAGALLPEEVSVYMETG
                     FFGMEGKMNSGDAHLAVNYQKLLQFGLRGFEERARKAKVALDLTDPASIDKYHFYDSI
                     FIVIDAIKVYAKRFVALAKSLAENANPKRKKELLEIADICSRVPYEPATTFAEAIQSV
                     WFIQCILQIESNGHSLSYGRFDQYMYPYMKADLESGKETEDSIVERLTNLWIKTITIN
                     KVRSQSHTFSSAGSPLYQNVTIGGQTRDKKDAVNPLSYLVLKSVAQTHLPQPNLTVRY
                     HAGLDARFMNECIEVMKLGFGMPAFNNDEIIIPSFIAKGVLEDDAYDYSAIGCVETAV
                     PGKWGYRCTGMSYMNFPKVLLITMNDGIDPASGKRFAPSFGHFKDMKNFSELENAWDK
                     TLRYLTRMSVIVENSIDLSLEREVPDILCSALTDDCIGRGKHLKEGGAVYDYISGLQV
                     GIANLSDSLAAIKKLVFEEERISPSQLWHALETDYAGEEGKVIQEMLIHDAPKYGNDD
                     DYADKLVTAAYDIYVDEIAKYPNTRYGRGPIGGIRYSGTSSISANVGQGRGTLATPDG
                     RNAGTPLAEGCSPSHNMDQHGPTSVLKSVSKLPTDEIVGGVLLNQKVNPQTLAKEEDK
                     LKLIALLRTFFNRLHGYHIQYNVVSRETLIDAQKHPEKHRDLIVRVAGYSAFFNVLSK
                     ATQDDIIGRTEHTL"
     gene            complement(7467..8765)
                     /locus_tag="VVO18_001664"
     CDS             complement(7467..8765)
                     /locus_tag="VVO18_001664"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000041357.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU5586777.1"
                     /translation="MSKMDVQKIIAPMMKFVNMRGIIALKDGMLAILPLTVVGSLFLI
                     MGQLPFEGLNKSIASVFGANWTEPFMQVYSGTFAIMGLISCFSIAYSYAKNSGVEALP
                     AGVLSVSAFFILLRSSYIPKQGEAIGDAISKVWFGGQGIIGAIIIGLVVGSIYTFFIK
                     RKIVIKMPEQVPQAIAKQFEAMIPAFVIFLSSMIVYILAKSLTNGGTFIEMIYSAIQV
                     PLQGLTGSLYGAIGIAFFISFLWWFGVHGQSVVNGVVTALLLSNLDANKAMLASGNLS
                     LENGAHIVTQQFLDSFLILSGSGITFGLVVAMLFAAKSKQYQALGKVAAFPAIFNVNE
                     PVVFGFPIVMNPVMFVPFILVPVLAAVIVYGAIATGFMQPFSGVTLPWSTPAILSGFL
                     VGGWQGVVTQLLVLAMSTMVYFPFFKIQDRLACQNEIKQS"
     gene            complement(8782..9090)
                     /locus_tag="VVO18_001665"
     CDS             complement(8782..9090)
                     /locus_tag="VVO18_001665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238716.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5586778.1"
                     /translation="MVKIGLFCAAGFSTGMLVNNMKIAAQSSGVEAEIEAFSQSKLAD
                     YAPNIDVALLGPQVAYTLDKSKEICDKCDVPIAVIPMMDYGMLDGKKVLDLALSLISG
                     "
     gene            complement(9136..9456)
                     /locus_tag="VVO18_001666"
     CDS             complement(9136..9456)
                     /locus_tag="VVO18_001666"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU5586779.1"
                     /translation="MEIIVPDQIIMGLILYAGDAKQHIYKALDYIKNGTCERCEEEIQ
                     LADAALLEAHNLQTKFLAQEASGTKTEITALFVHSQDHLMTSMTEINLIKEIISLRKE
                     LHKK"
     gene            complement(9651..10631)
                     /locus_tag="VVO18_001667"
     CDS             complement(9651..10631)
                     /locus_tag="VVO18_001667"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar-binding transcriptional regulator"
                     /protein_id="HEU5586780.1"
                     /translation="MNQDRNKLLSKIAYLYYIENLNQSQIAAKLGIYRTSISRMLTEA
                     RNAGIVKIEIENFDTNMFKLENYVKEKYGLESLEIIPNEFDDNPTILSERISQVAAGV
                     LRNLIDDNMKIGFSWGKSLSNLVDLIHSKSVRNVHFYPLAGGPSHIHAKYHVNTLIYE
                     MSRKFHGECTFMNATIVQENKLLADGILQSRYFENLKNSWKDLDIAVVGIGDFSNKGK
                     HQWLDMLTEDDFKELTKVKTVGEICCRFFDSKGKEVYENLQERTIAISLEDLKNIPQS
                     LAVAYGDTKVSSILSVLRANLVNHLITDKNTILKVLEEDGDLTFREILGE"
     gene            complement(10644..>11264)
                     /locus_tag="VVO18_001668"
     CDS             complement(10644..>11264)
                     /locus_tag="VVO18_001668"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000824973.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DeoR/GlpR transcriptional regulator"
                     /protein_id="HEU5586781.1"
                     /translation="KGLLHREHGYAVLNSGDDLNVRLSINYEIKRKIVQEAVKLVSDN
                     ETIMIESGSTCALLAEEICKQKRNVTIVTNSFFIANFVRAYDSCRIIVLGGEFQKDSQ
                     VTVGPLLKEMIQTFHVHQAFVGTDGYDKEMGFTGKDLMRSEVVQYISAASDKVIVLTD
                     SSKFDKRGTVRRFALSQVYEVITDEKLSKQNIATLENAGIMVKVVS"
BASE COUNT         3501 a         2378 c         1759 g         3626 t
ORIGIN      
        1 tctaaaagta actctaaagt tcatactcta gagttacttc tttttatttc acaacaatgt
       61 taactaattt agttggcttc aatagtccag tggactattg aaggtggcag atagagctaa
      121 taaactcgtt atttaacgac gatattaacg agtttattcg gtaccgcaat tactttcacg
      181 atttccttac cgtcaatttc tgctttgact ttttcatcag ctaaagcgat ttcttgtaat
      241 tcttcacgtg atagatcttt agcaaccatg agtttggcac gaacttttcc tttgatttgg
      301 acgacaattt caatttcatc ttcaaccaat ttgctttcgt cccaagttgg ccaagctaca
      361 taagagattg actcacctgt ttctgcgact gtttgccaga gttcttctgc caagtgaggt
      421 gcaaatggtg caatcaattg aataaagcct ttggcatagt caatataaag cttatcttcc
      481 ttgttagcag cattgacaaa gaccataagt tgggcaatag ctgtgttgaa tttgagagac
      541 tcaatttgct cagtaacagc tttgactgtt tcgttgtaag ccttgtcaag agcaccattg
      601 ttttccgcaa ggatttcttt acttgtaatc aaacggtaaa ctcggtcaag gaacttacgg
      661 cttccttcca aaccttcttc tgaccaagca atcgaagcat cgagtggtcc cataaacatt
      721 tcataaacac gaagggtatc ggcaccgtat tgttccacca catcgtctgg gttaacaacg
      781 ttcttgagcg atttagacat cttggctggc gcttgctcca actcttcccc tgtttctaca
      841 tggaagaagg aaccatcacg tttttcaacc ttgtcggttg tcacaagagc accacggtgg
      901 tcacggtagc ttgttcccaa aatcatccct tggttaaaga gtttttggaa tggttcctta
      961 gtcggaacaa caccgaggtc atagaggaat ttatgccaga aacgagcata aagcaagtga
     1021 agtacagcat gttccgcacc acccacgtag atatctactg gcaaccattg tttgaggagg
     1081 tcctcatcag ccaatttctc agtattgtgc gggtcaatat agcgaaggta gtaccagctt
     1141 gaaccagccc attgtggcat ggtgttagtt tcacgacgac ctttgacacc atcttcacga
     1201 gtcacttcaa gccagtctgt caagttagct agtggacttt caccggtacc tgaaggacgg
     1261 atgtccttgg tgacaggcaa gacaagcggc aattcagttt caggaacagc tgttgaagtt
     1321 ccatcttccc aatgaataat tggaattggt tcaccccagt aacgttgacg gctaaagagc
     1381 cagtcgcgga gacggtaggt aaccttctcc tgaccacagc ctttttcttc caagtaagcc
     1441 acaatcttgg caatagcgtc ttctttgttc aatccatcta ggaagtctga attgacatgc
     1501 aggccatcct ctgtgtaggc agcttcttcg acatttccac cttcaagtac ttcgacgatt
     1561 ggaaggtcaa attgtttggc aaattcccag tcacgttggt cgtgggcagg cacagccata
     1621 accgcacctg ttccataact agcaagaaca tagtccgcaa tccagattgg catttcctta
     1681 ccattgacag ggttgatggc ataagcacca gtccaaacac cagttttttc cttagcaagg
     1741 tctgtacgaa ccaagtcaga cttaaggctg gcttggtgtt tatagtctgc tacagcttct
     1801 gcttgctctg aacttgtgat agcgtctact aattcatgtt caggagccaa gacagtgaaa
     1861 gtcgcaccga aaagtgtgtc cggacgagta gtaaagactg taaattcctt gtctgttcct
     1921 tttactttga aagttacatt ggcaccagtt gatttaccaa tccagttgcg ttgcatatcc
     1981 ttgatagact ctgaccaatc tagttcatct aagtcattga gcaagcgctc tgcgtaagcc
     2041 gtgattttga gcatccattg gcgcattggt ttgcggacaa ctggatagcc tccacgctca
     2101 gaagttccgt caggaagcac ttcttcattg gcaatggcag ttcccaattc ctcaacccag
     2161 tttactggca cttcagcttc ataggccaag cctttttcgt aaagcttggt gaaaatccat
     2221 tgagtccact tgtagtagtt tggatctgtt gtgttgactt cacgatccca gtcataagaa
     2281 aatccaagcg cattgatctg acgtttgaag ttggcaatgt tttccgctgt aaattctgct
     2341 gggtcattac cagtatccat agcgtattgc tctgcaggca aaccaaaagc atcccaaccc
     2401 attgggtgaa ggacattgta gccttgcgca cgtttgtaac gactgaggat atcggttgca
     2461 gtataacctt ctgggtgtcc tacgtgcaga ccagctccag acggataagg gaacatatca
     2521 agcgcataaa acttaggttt tgatgcatct gttcctgtct taaatgtatg atgttctgcc
     2581 cagtagccct gccacttagg ctcaatttct ttatgattat aaaaactcat ggtctctctc
     2641 caattttgtg atgttactat tataccattt ttgagggaat ttgaaatgtg tttaaagaaa
     2701 aaactgtata ctgtatctca ttaattttga tgactatgaa ttgctctatc tcccactttt
     2761 tatcccattg ttatgcagta aatcaaggag taagtcaaga agcttatctc gtatagcaca
     2821 aaatacttat tttagaccga agataaaact ggaatgctaa ttaatgtatt cacaataaat
     2881 agccgactac ctatgtcgct ttttgattta tgaagaacgt atagtagact gaatctgaaa
     2941 tagtacgaaa caattgctaa aacatttata gaaattaatt ttactttccc aatcgatttg
     3001 ttctcatcct atttcaatct tctatagaat tcaatacagg gatcaataaa agactaccat
     3061 ttggaaaaca gtagtcctta ttgtttattt tgaatttaca taggcatcta cagcgataat
     3121 agcttgagca acatctgaag gcgaaatctt aaacggcatc tgatgaattg tctcaccctc
     3181 catagttgct tgtttaccaa cttttattaa atcatcatat ccaacttgat ccaaatgcat
     3241 ttcttttaga gttgttggca taccaatttt tttgtaaaac tcaatatact tatcaagttc
     3301 ttctttaggt ctattttcca ataatagttg tactaaagtt ccataagcta ctttttcacc
     3361 atgtgttaaa tgatgaatgt cacctgtcaa tgcagtaaaa ccattatgaa ttgcatgcgc
     3421 cgcagctaat cctccacttt caaaacctag accactcaat aaagtattag cttcaacaat
     3481 attttctaat gctggtgtca ccactttagc ttcacaagct gccatagcct gtaaaccatc
     3541 tgcaaacagc gtttcttcac atttcttcgc aattgcaact ccagccaatg tttgctgttg
     3601 tcccaacata gtttttccat ttgcctgcat aaccgcacgc gcctcaaccc aagttgctaa
     3661 accatctgca ataccagacg ctaataaacg cttaggggct tgtgaaataa cttttgtatc
     3721 aaccaaaact aaatctggat ttttagaata aaatagataa tgatcaaatg caccttcatc
     3781 tgtataaata acagataaag cagatacagg tgcgtcggtc gatgcaattg ttggagcaat
     3841 aataacaggc ttttcaatca aatctgcaat agcttttgcg ctatcaatcg tctttccccc
     3901 accaagaccg ataatactat cacaattttc tttctcagcc aaggcaacaa ctcgattgat
     3961 ttcattgtca gaagcttcac cattaaatag cgccagaaca atatggaaac catacctatg
     4021 tagataatct tcaaatcgtt ttccaacaat atcataaacc aactgatcgc ataatagaat
     4081 cgggtaattt cccaaatcca aaattgattt ggcattttca aacaaggcat tttccccctg
     4141 aatatatcta gaaggactag caaaaattct catatgtatt tcctctctat ctaaatggaa
     4201 cgactatttt gagtaacaaa ccaatcgtca gaaaaatcat caaccgcctt ttggatagat
     4261 ggcatggcga aagctgattc aaaaacatct gctcctgctg taacagcatg cgcacctgca
     4321 gctaaagcat tatttacttg tgctacattt ttaaaggatg cagctaaaat cttactagga
     4381 gagttctgtc tatcaatagc aagagctaat tgacgaatga cagaatttga atcaatgttc
     4441 agattttcca ttctattata atatggagct aggtaatccg ctcctgcttc gatagctaat
     4501 aatccctgaa taactgtata aatagctgtt gcagtgatat ggtagccctc tttttttagc
     4561 acctttattg cacgtaatcc agctggagta acaggtactt tgataaatat atcatctcct
     4621 gcttgtcttc gaatttcatg agcatccttt aagatgcctt caaaatcttg agaaatcacc
     4681 tgaacatgaa tagagggtgt agagccaatc aattctctta catctttgat tcgttcaaaa
     4741 aaattaatag aaccctctct ttttgcaata gtgggatttg aagttacccc agctagcggc
     4801 aaaatttcag accacttttt aatctcatct aaatttaatg tgtcaagcat aaattccata
     4861 aaaagaacct ctttatttta caaagtatgc tcagtacgtc ctataatgtc atcttgggtt
     4921 gccttagaaa gaacattgaa gaatgcagag tatcctgcaa cacgaacaat taagtctctg
     4981 tgtttttcag gatgtttctg agcgtcaatc agcgtctctc tggaaacaac attgtattga
     5041 atatggtacc catgtaaacg attaaagaat gttcgtaaca aagcaattag ttttaattta
     5101 tcttcttctt tggctaacgt ttgaggattt actttctgat ttaagagaac cccacctacg
     5161 atttcatctg ttggtaattt tgaaacagat tttaaaacag atgtagggcc gtgttgatcc
     5221 atattatgtg atggtgaaca accctctgct aacggtgtac ccgcgttgcg tccatctgga
     5281 gttgctaatg ttccacgtcc ctgccctacg ttggctgaga tagaagatgt tcctgaataa
     5341 cgaattcctc caattggacc tcttccataa cgtgtattag gatatttagc aatttcatca
     5401 acataaatgt cataagcagc agtaaccaat ttgtcagcat aatcatcatc attaccatac
     5461 ttaggtgcat catgaatcaa catttcttga atgaccttac cttcttctcc ggcataatct
     5521 gtttccagtg catgccaaag ctgacttggg cttatacgtt cttcctcaaa caccaatttt
     5581 ttaattgcag ctaatgaatc cgacaaattt gcaattccaa cttgcaatcc tgatatataa
     5641 tcatatactg ctccaccttc tttaaggtgt tttccacgac caatacaatc atcagtcaat
     5701 gctgaacata gaatatcagg aacttctcgt tccaatgata aatcaataga attttcaaca
     5761 ataacactca ttcgtgtcaa atatcttagt gttttatccc aagcattttc taattcagaa
     5821 aagttcttca tatccttaaa atgaccaaag cttggtgcaa accgtttacc cgaagccgga
     5881 tcaattccat cattcatcgt gataagtaga accttaggga agttcatata actcatacct
     5941 gtgcaacgat agccccattt ccccggaact gccgtttcaa cacatccaat ggcactgtaa
     6001 tcataagcat catcttccaa tactcctttt gcaataaaag aaggaataat aatctcatca
     6061 ttattaaatg caggcatacc aaaaccaagt ttcatcactt caatacactc attcatgaaa
     6121 cgagcatcta aacctgcatg gtaacgtaca gttagattag gttgcggtag atgggtttgt
     6181 gcaactgatt ttaataccaa ataagataat gggttaacag catccttctt atctcgagtc
     6241 tgtccaccaa ttgtaacatt ttgatataaa ggacttcctg ctgaagaaaa tgtatgtgat
     6301 tgactgcgaa ccttattaat tgtaattgtc ttaatccaaa gatttgtcag acgttcaaca
     6361 atgctatctt ctgtttcttt accactttct aaatcagcct tcatatatgg atacatatat
     6421 tgatcaaaac ggccatatga aagagagtgg ccattagatt caatttgtaa aatacattga
     6481 ataaaccaaa ctgattgaat agcttctgca aaagtagttg ccggttcata tgggactcta
     6541 gagcaaatat ctgcaatctc aagtaattct ttcttacgtt taggatttgc attttcggct
     6601 aaacttttag caagagcaac aaagcgcttt gcatatactt taatagcatc gattacgata
     6661 aatatagagt cgtaaaaatg atatttatca atacttgctg gatctgttaa atctagagct
     6721 accttcgctt tacgagcccg ctcttcaaaa cctcttaaac caaattgcaa aagtttctga
     6781 tagttaactg ctaagtgagc atctccagaa ttcatcttac cttccatacc gaagaatcct
     6841 gtttccatat aaacagacac ttcttcaggt aataaggcac cagctctagc acgtaaatta
     6901 ttattttccc aaaacggagc aatacttcta agttgttctt ttgtttcttc tgtaatatag
     6961 aaaacatctc catcacgctt ttcaaaaaga tccaactcat tgagaacaaa ttctagcgta
     7021 tattccggaa aaataggagc atctttattg gaagaagctt gatttcccgc aatcatagat
     7081 tcttcttcaa tatagataga catattttcc aaaatttctt tcagcatata tgcacgtttt
     7141 aggacattag gttgttcctt gtatcgttca taggcgcgtg ttgctagaac tgctctctca
     7201 gcatcaatat aaggtttttt atttaaaaca tcttctcgat atttgttcat cctttcagta
     7261 aggctgccaa aatattctgt cttgattgtt gttcttgcta cttctgtatt taccatcgta
     7321 agcacctttc tttcgaaaat gtttttattt ctttcgaaaa tataataccg atttttatag
     7381 aaattttcaa gcttttaact agaaaaattt taactctcta atttttagca caaatgtgtg
     7441 agtttaacag taacacacaa atacctctaa gattgtttga tttcattttg gcaagctaaa
     7501 cgatcttgta tcttaaagaa tggaaagtaa accattgtag acatcgccaa tactaataac
     7561 tgagtcacaa caccttgcca tccacccacc aaaaatcctg atagaatagc tggtgtactc
     7621 caaggcaatg ttacccctga gaatggttgc atgaaacctg ttgcaatagc tccatatact
     7681 atcacagctg caagtacagg aacaagaatg aaaggtacaa acataactgg attcatgaca
     7741 atcggaaatc caaatacaac tggctcattt acgttaaata ttgctggaaa agctgcaact
     7801 tttcctaagg cttggtattg ttttgatttt gctgcaaaaa gcatggcaac tacaagacca
     7861 aacgtaatcc ctgaacctga tagaattaaa aatgaatcta aaaattgttg agtaacaata
     7921 tgtgcaccat tttctaatga tagattacca gaggctaaca tagctttatt agcatcaaga
     7981 ttagataaaa gcagagctgt cactactcca tttactaccg attgcccatg aacaccaaac
     8041 caccacaaaa atgatataaa gaatgcaatt ccaatagcac catacaaaga tccagttaaa
     8101 ccttgcaacg gaacttgaat agcagaataa atcatttcta tgaatgttcc gccattagtc
     8161 aatgacttcg ctaaaatata tacaatcata gaagataaga aaattacaaa tgctggaatc
     8221 attgcttcaa actgtttggc aatagcttgt ggaacttgtt ctggcatctt aataacaatt
     8281 tttctcttta taaagaaggt ataaatactt cctactacca aacctataat gatagcaccg
     8341 ataattcctt ggcctccaaa ccaaacttta ctaatagcgt ccccaatcgc ctcaccttgt
     8401 ttagggatat aagatgatct tagcaaaata aagaatgcag atacagatag aactccagct
     8461 ggtaaagcct ctactccgct attcttagca taagaatagg caattgaaaa acaagaaatt
     8521 agacccataa tagcaaaagt tcctgaatat acttgcataa acggctctgt ccaattagct
     8581 ccaaaaacac tagcaatgct cttatttaat ccttcgaacg gcaattgtcc cataatcaag
     8641 aacaaactgc caactactgt caatggcaaa attgctaaca tcccatcttt tagagctata
     8701 atgccacgca tattcacaaa cttcatcatc ggtgcaatga ttttctgaac atccatcttt
     8761 gacataataa atctcctttt cttacccact aatcaaagat agggccaaat ctaatacttt
     8821 tttcccatct aacataccat agtccatcat cggaataaca gctatcggaa catcacactt
     8881 atcacaaatt tcttttgatt tatctaatgt ataagcaact tgtggaccca atagtgcaac
     8941 atctatattt ggcgcataat ccgctaattt agactgagaa aacgcctcta tttctgcctc
     9001 aactccacta gattgcgctg caattttcat attatttaca agcataccag tagaaaaacc
     9061 tgctgcacaa aacaaaccaa tcttcaccat tatgttttcc tcctctatgt taataacaat
     9121 gataatactc tagtattatt ttttatgaag ttcttttctc aaactaataa tttctttgat
     9181 taaattaatc tccgtcatac tagtcatgag atgatcttgt gaatgaacaa agagagctgt
     9241 aatttctgtc tttgtaccag acgcttcctg tgccaagaat tttgtttgta gattatgagc
     9301 ttctaataag gctgcatcag ctaactggat ttcttcttca catcgttcac atgtaccgtt
     9361 ctttatgtaa tctaatgctt tataaatatg ttgtttcgca tcgccagcat ataaaattaa
     9421 acccatgata atttgatctg gaacaataat ttccataaat tcctcctcat ttcactatgt
     9481 aaaaagcttt tttcatttga aattttaaaa ttttcttttg taactataga atacaactac
     9541 ataataaagt tgtcaatcca aaaacaacag ataaactatt tttgtttata taagcacaaa
     9601 tgtgcaatca actaaaaaga aaaacgataa actgaatcag tctatcattt tcactcacct
     9661 agaatctctc taaaagtcaa atccccatct tcttccaaaa cttttaaaat tgtatttttg
     9721 tctgtaatca aatgatttac taaattagca cgcaagacag aaagaatcga agatactttc
     9781 gtatcaccgt aagcaacagc taaactttga ggaatatttt ttaaatcttc caaagagatt
     9841 gctatcgttc tttcctgtaa gttttcatag acttctttac cttttgaatc aaaaaatcga
     9901 caacaaattt ctcctacagt tttaactttg gtcaattctt taaagtcatc ctctgtaagc
     9961 atgtctaacc attgatgctt tcctttattg ctaaaatcac caattccgac tacagctata
    10021 tctaaatctt tccaactatt tttcaaattt tcaaaatatc ttgattgcaa aataccatct
    10081 gctaacaatt tattttcttg cacaatcgtt gcattcataa atgtacactc tccatgaaat
    10141 tttctagaca tttcataaat cagtgtattc acatggtatt tagcgtgtat gtgactagga
    10201 ccacctgcta gaggatagaa gtgaacattt cggacacttt tactgtgaat taaatctact
    10261 aaattactta aacttttccc ccaagaaaag ccaattttca tattatcatc aattagattc
    10321 ctaaggacac ctgctgcaac ttgagaaatt ctttcagata aaattgttgg attatcatca
    10381 aattcatttg gaataatttc taaactttcc agaccatatt tttcttttac ataattttcc
    10441 aacttaaaca tattggtatc aaaattctct atttcaattt taacaattcc tgcattcctt
    10501 gcttctgtta acattctact aatagaggtt ctataaattc ctaattttgc tgctatttgt
    10561 gactgattta agttttcaat ataatacaga taagcaattt tagagagcag tttattccta
    10621 tcttgattca tacacttaac ctcttacgaa actaccttaa ccattatccc agcattttct
    10681 aatgtagcta tattttgttt agaaagtttt tcgtctgtta ttacttcata gacttgactt
    10741 aaagcaaatc ttcttactgt acccctttta tcaaatttac ttgagtcagt tagtacaatg
    10801 actttatccg acgctgctga aatatattga actacctcac tgcgcattaa atcttttcct
    10861 gtaaagccca tctctttatc gtagccatct gtcccaacaa aagcttgatg cacatgaaaa
    10921 gtctgtatca tttcttttaa taaaggtccc acagtaacct gtgaatcctt ctgaaactct
    10981 ccaccaagaa caataatacg acatgaatca taagctctca caaaatttgc tataaaaaat
    11041 gaatttgtta caatcgtaac atttcttttt tgcttgcaaa tttcctcagc aagtaaagca
    11101 caggtcgatc cagattctat cattattgtt tcattatctg acaccaattt tactgcttcc
    11161 tgaacaattt ttctcttaat ttcataatta attgacaaac gtacatttaa gtcatctcca
    11221 ctatttaata cagcatatcc atgctctctg tgtaataaac cttt
//
LOCUS       DAVHIZ010000053        11073 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.055, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000053 DAVHIZ010000000
VERSION     DAVHIZ010000053.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 11073)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11073)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11073
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.055"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            32..754
                     /locus_tag="VVO18_001669"
     CDS             32..754
                     /locus_tag="VVO18_001669"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619140.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="HEU5586782.1"
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLL
                     KGMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPL
                     FRSLKTKHWKKVQEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEP
                     FAGIDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKIPHYFDQVLLVNREVIAFGPTKE
                     TFTETNLKEAYGNQLFFNGGDL"
     gene            751..1599
                     /locus_tag="VVO18_001670"
     CDS             751..1599
                     /locus_tag="VVO18_001670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000559784.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter permease"
                     /protein_id="HEU5586783.1"
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGIVAGAVGCFIILRGMSLM
                     GDAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSS
                     FLALGIILIGVAKSSTDLFHILFGNILAVQDTDMFITMGVGAAILLLIWIFFKQLLIT
                     SFDELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANS
                     LKSMIFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLK
                     NKHLLK"
     gene            1631..2560
                     /gene="psaA"
                     /locus_tag="VVO18_001671"
     CDS             1631..2560
                     /gene="psaA"
                     /locus_tag="VVO18_001671"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733059.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal ABC transporter substrate-binding
                     lipoprotein/adhesin PsaA"
                     /protein_id="HEU5586784.1"
                     /translation="MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIAD
                     ITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTK
                     LVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSA
                     KDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVP
                     SAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQ
                     IFTDSIAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     gene            2683..3174
                     /gene="tpx"
                     /locus_tag="VVO18_001672"
     CDS             2683..3174
                     /gene="tpx"
                     /locus_tag="VVO18_001672"
                     /EC_number="1.11.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004245092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol peroxidase"
                     /protein_id="HEU5586785.1"
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKK
                     KVLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGLDNAIM
                     LSDYFDHSFGRDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAA
                     KAL"
     gene            complement(3270..5978)
                     /locus_tag="VVO18_001673"
     CDS             complement(3270..5978)
                     /locus_tag="VVO18_001673"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000595876.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEU5586786.1"
                     /translation="MIKRKTYWKDLIQSFTGSKGRFLSILILMMLGSLALVGLKVTSP
                     NMETTANAYLTTAQTLDLAVMSNYGLDQADQEELRQTEGAEVEFGYLTDVTMDNGQDA
                     IRLYSKPERISTFQLRKGRLPQSDKEIALATHLQGQYSVGQEISFKEKEEGHSSLKDH
                     TYTITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGL
                     NAFSSAYEEKSKQHQEELEQILSDNGKVRLQLLKKEGQESLDKGQETLDKAQTNLQEG
                     KRRLAAAQARIQAQESQLALFPQVQREQASAQLTQAKQELGKEEDKLKQAEQNLAQEK
                     EKLEKHQQVLDDLAEPRYQVYNRQTMPGGQGYLMYSNASSSIRAVGNIFPVVLYAVAA
                     MVTFTTMTRFVDEERTHAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLL
                     ASVISSVITKGMVVGETQIQFYWTYSLLALVLSWLASVLPAYLVAWRELHDEAAQLLL
                     PKPPVKGAKILLERIGFIWRRLSFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGL
                     GIQSSVAGVPSKQFQQIQQYQMLVSENPSATNQDKVELAEVLKGQEILAYQKIYSKTL
                     DKDFKGKAGLQNITLMMIEKEDLTPFIHLQHHQQELTLKDGIVITAKLAQLAGVKVGQ
                     TLEIEGKELKVAAITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIESQ
                     AGLLMSQSAVSSVVQNASAIRLFDSIASSLNQTMTILVIVSVLLAIVILYNLTNINVA
                     ERIRELSTTKVLGFHNNEVTLYIYRETIVLSLVGIVLGLVAGFYLHQFLIQMISPATI
                     LFYPQVGWEVYVIPVAAVSIILTLLGFFVNYYLRKVDMLEALKSVE"
     gene            complement(5980..6681)
                     /locus_tag="VVO18_001674"
     CDS             complement(5980..6681)
                     /locus_tag="VVO18_001674"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399621.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586787.1"
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGA
                     GKSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTA
                     KENVELASEIVTDALNPDQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKIL
                     LCDEPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNGALAPIADRVIHMHDASVKD
                     VVLNQHPQDIDSLEY"
     gene            complement(6931..9342)
                     /locus_tag="VVO18_001675"
     CDS             complement(6931..9342)
                     /locus_tag="VVO18_001675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000620712.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 95 protein"
                     /protein_id="HEU5586788.1"
                     /translation="MIRNKKQDYVLAYKQPASTTYMGWEEEALPIGNGSLGAKVFGRI
                     GAERIQFNEKSLWSGGPLPDSSDYQGGNLQDQYVFLAEIRQALEKRDYNLAKELAEQH
                     LIGPKTSQYGTYLSFGDIHIEFSQQGTTLSQVTDYQRQLNISKALVTTSYVYKGTRFE
                     REAFASFPDDLLVQRFTKEGAETLDFTIELSLTCDLASDEKYEQEKSDYKECKLDITD
                     SHILMKGRVKDNDLRFASYLAWETDGDIRVWSDRVQISGASYANLFLAAKTDFAQNPA
                     SNYRKKLDLEQQVIDLVDTAKEKGYTQLKSRHIEDYQALFQRVQLDLEADVDASTTDD
                     LLKNYKPQEGQALEELFFQYGRYLLISSSRDCPDALPANLQGVWNAVDNPPWNSDYHL
                     NVNLQMNYWPAYVTNLLEAVFPVINYVDDLRVYGRLAAVKYAGIVSQKGEENGWLVHT
                     QATPFGWTAPGWDYYWGWSPAANAWMMQTVYEAYSFYRDQDYLREKIYPMLRETVRFW
                     NAFLHKDQQAQRWVSSPSYSPEHGPISIGNTYDQSLIWQLFHDFIQAAQELGLDEDLL
                     TEVKEKSDLLNPLQITQSGRIREWYEEEEQYFQNEKVEAQHRHASHLVGLYPGNLFSY
                     KGQEYIEAARASLNDRGDGGTGWSKANKINLWARLGDGNRAHKLLAEQLKTSTLPNLW
                     CSHPPFQIDGNFGATSGMAEMLLQSHAAYLVPLAALPDAWSTGSVSGLMARGHFEVSM
                     SWEDKKLLQLTILSRSGGDLRVSYPDIEKSVIKMNQEKIKAKCMGKDCISVATAEGDL
                     VQFYF"
     gene            complement(9395..10087)
                     /locus_tag="VVO18_001676"
     CDS             complement(9395..10087)
                     /locus_tag="VVO18_001676"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006703946.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoglycerate mutase"
                     /protein_id="HEU5586789.1"
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIK
                     EAGIKFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAA
                     EQFGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERAL
                     PFWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDE
                     KLNVVSEYYLGK"
     gene            complement(10622..10984)
                     /locus_tag="VVO18_001677"
     CDS             complement(10622..10984)
                     /locus_tag="VVO18_001677"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000842495.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586790.1"
                     /translation="MKSSGIVGLVGGILLLICPFVLLGTAVNTAATTLNGGATAGAFS
                     GVALLLNALKIANLVLGIIAIVYYKGDKRVGAAPSVLMIVSGEVSLIPFLGWVGGILA
                     IIGGSLFLATLKKFKSEE"
BASE COUNT         3235 a         2535 c         2068 g         3235 t
ORIGIN      
        1 gtatattaag agacaggagg aatacaagtt tatgatacgt atcgaaaacc tcagtgtctc
       61 ctacaaagaa acgttggcac ttaaggatat ttcactagtg ctccatggac caacaattac
      121 cggcatcatt ggtccaaacg gcgctgggaa atcaacacta ttaaaaggta tgctgggaat
      181 tatcccacat caaggtcagg catttctcga tgacaaggaa gttaaaaaat ccttacaccg
      241 aattgcctat gtcgaacaaa aaatcaatat cgactacaac tttcccatca aggtcaagga
      301 atgcgtctcg ttaggactat ttccctctat tcctctcttt cgaagtttaa agactaaaca
      361 ttggaagaaa gtgcaagagg cccttgaaat cgtcggccta gctgactacg ctgaacgtca
      421 aattagtcaa ctgtctggag gtcaattcca gcgggtcttg attgccagat gtttggtgca
      481 ggaagccgac tatatcctct tggatgaacc ctttgctggg attgactctg tcagtgagga
      541 aatcatcatg aatacgctga gagatttgaa aaaagctggg aagacggttc tcatcgttca
      601 ccacgacctc agcaagattc cccactactt cgatcaagtc ttacttgtca atcgagaagt
      661 gattgccttt ggtccaacaa aagaaacttt taccgaaacc aatctaaaag aagcttacgg
      721 taatcaactc tttttcaatg gaggtgacct atgattgcag aatttatcga tggattgcaa
      781 aaattccatt tcctacaaaa tgccttgata acagctattg tcgtcgggat tgtagctgga
      841 gccgtgggat gtttcattat tctacgcggg atgtcactca tgggagatgc catttcacat
      901 gctgtcttac caggtgtagc cctctccttc atcttgggcc ttgacttctt tatcggagcc
      961 attgtctttg gattgctagc tgccatcatc attacctaca tcaaaggaaa ctcgattatc
     1021 aaaagcgata ccgccatcgg cattaccttt tcttctttct tagccctcgg tatcatcttg
     1081 attggtgtcg ctaaaagttc aactgacctt ttccatatcc tttttggtaa tatcctggcc
     1141 gtccaagata cggatatgtt tattactatg ggtgtggggg cagccatcct cttgttaatc
     1201 tggattttct tcaagcaact cttgataact tcctttgatg aactcttggc taaagccatg
     1261 ggaatgcctg tcaatttcta tcactacctt ctcatggtac tcctgactct cgtgtctgtg
     1321 acagccatgc aaagtgtcgg aactatcctg attgtagcca tgctgattac cccagctgca
     1381 actgcttatc tgtatgctaa tagtctgaaa agcatgattt tcctttcctc aaccttcgga
     1441 gctactgctt cagttttggg actctttatt ggctatagtt ttaatgttgc ggcaggttct
     1501 agtatcgtgc ttacagctgc tagtttcttt ctcattagct tctttatcgc tcccaaacaa
     1561 cgatatttga aactgaaaaa taaacatttg ttaaaataag gggcaaagcc ctaataaatt
     1621 ggaggatcta atgaaaaaat taggtacatt actcgttctc tttctttctg caatcattct
     1681 tgtagcatgt gctagcggaa aaaaagatac aacttctggt caaaaactaa aagttgttgc
     1741 tacaaactca atcatcgctg atattactaa aaatattgct ggtgacaaaa ttgaccttca
     1801 tagtatcgtt ccgattgggc aagacccaca cgaatacgaa ccacttcctg aagacgttaa
     1861 gaaaacttct gaggctgatt tgattttcta taacggtatc aaccttgaaa caggtggcaa
     1921 tgcttggttt acaaaattag tagaaaatgc caagaaaact gaaaacaaag actacttcgc
     1981 agtcagcgac ggcgttgatg ttatctacct tgaaggtcaa aatgaaaaag gaaaagaaga
     2041 cccacacgct tggcttaacc ttgaaaacgg tattattttt gctaaaaata tcgccaaaca
     2101 attgagcgcc aaagacccta acaataaaga attctatgaa aaaaatctca aagaatatac
     2161 tgataagtta gacaaacttg ataaagaaag taaggataaa tttaataaga tccctgctga
     2221 aaagaaactc attgtaacca gcgaaggagc attcaaatac ttctctaaag cctatggtgt
     2281 tccaagtgcc tacatctggg aaatcaatac tgaagaagaa ggaactcctg aacaaatcaa
     2341 gaccttggtt gaaaaacttc gccaaacaaa agttccatca ctctttgtag aatcaagtgt
     2401 ggatgaccgt ccaatgaaaa ctgtttctca agacacaaac atcccaatct acgcacaaat
     2461 ctttactgac tctatcgcag aacaaggtaa agaaggcgac agctactaca gcatgatgaa
     2521 atacaacctt gacaagattg ctgaaggatt ggcaaaataa gcctctgaaa aacgtcattc
     2581 tcatgtgagc tggcgttttt tctatgcaca catttccggt caaatcattg gaaaattctg
     2641 actgtttcag atacaatgga agaaaaaaga ttggagtatc ctatggtaac ttttctcgga
     2701 aatcctgtga gctttacagg taaacaacta caagtcggcg acaaggcgct tgatttttct
     2761 cttactacaa cagatctttc taaaaaatct ctggctgatt ttgatggcaa gaaaaaagtc
     2821 ttgagtgtcg ttccttctat cgatacaggc atctgctcaa ctcaaacacg tcgttttaat
     2881 gaagaattgg ctggactgga caacacggtc gtattgactg tttcaatgga cctacctttt
     2941 gctcaaaaac gttggtgcgg tgctgaaggc cttgacaatg ccattatgct ttcagactac
     3001 tttgaccatt ctttcgggcg cgattatgcc ctcttgatca acgaatggca cctattagca
     3061 cgcgcagtct ttgtcctcga tactgacaat acgattcgct acgttgaata cgtggataat
     3121 atcaattctg agccaaactt cgaagccgca attgcagctg ctaaagccct atagaaaaaa
     3181 tcctctgtca caaagagttc cctgctcttt gaaacggagg atttttgaat attagtaaat
     3241 agaagttcaa tcagctaaaa ataactacct tactctacag atttcagggc ttctaacatg
     3301 tcaacctttc tcagataata attgacgaag aaaccaagca aggtcaaaat gatgcttact
     3361 gctgccactg ggattacata gacttcccag cctacctgcg gataaaagag aatagtcgca
     3421 ggcgaaatca tttgaatcaa aaattggtgt aaatagaaac cagctaccag accaagtacg
     3481 attcccacaa gggatagcac aatcgtctca cggtaaatgt agagggtgac ttcattatta
     3541 tgaaaaccaa gaaccttggt agtggagagt tcacggattc tctcagctac gttgatattg
     3601 gtcagattgt aaaggatgac aatagctaat agaaccgata cgatgaccaa gatggtcatg
     3661 gtctgattga gtgagctagc gatagagtcg aagagtcgaa tggctgaagc attttggaca
     3721 acgctggaca ccgcagattg actcataagc aagcccgcct gactttcgat actagttgca
     3781 ctggtatccc ttaatgagac cagataagtg ttggcttggg gtagctgtcc gtaaagttgc
     3841 tcatagctag cctgactcat ataaataaag tgaccaacgt agttctcagt aatagcagcg
     3901 acctttagtt ccttaccttc aatttctaaa gtctgcccaa ccttgacacc tgccagctgg
     3961 gcgagtttag ctgtaataac gatgccatct tttaatgtca gctcctgctg atgatgttga
     4021 agatggataa agggagtcaa atcttccttc tctatcatca taagagtaat gttttgaaga
     4081 ccagccttgc ctttgaaatc cttgtctagc gttttagaat agattttctg gtaggctagt
     4141 atctcctgcc ctttcaacac ttctgctagc tctaccttgt cctgattggt cgcactagga
     4201 ttttcagaga caagcatctg atactgttgg atttgttgaa actgtttaga cggaactcct
     4261 gctacagaag attggattcc caaacctgca aagagcagag ctacagaacc tgccacacca
     4321 aagattgtca tcaacattct ctgcttataa cgaaagatgt tgcgggctgt taccttatga
     4381 gtaaaactga gacgacgcca gataaaaccg atacgctcca ataagatttt agctcctttg
     4441 acaggaggtt taggaagtag aagctgggct gcttcgtcat gaagttccct ccaagccacc
     4501 agataggctg gtaacacact cgccaaccag ctcaagacaa gagctagtaa gctataggtc
     4561 caatagaact gaatctgggt ttctcccacc accatgcctt ttgtaatgac acttgaaatt
     4621 acactggcta gcaaataatg accaagtata ctacctagag ccgttccgac agtcccagct
     4681 actagtccat aaaggagaaa cttggcgata atatccttac tacggtaacc caaggcctta
     4741 aaaatccctg catgagttcg ctcttcgtct acaaagcgag tcatggtcgt aaaggtcacc
     4801 atggctgcta cggcataaag taccacagga aagatattgc ccactgctcg aatactggat
     4861 gaagcattgc tatacataag atagccctga ccacctggca tggtctgacg attatagacc
     4921 tgataccttg gctccgccaa atcgtccaag acttgctgat gtttttctaa tttttccttt
     4981 tcttgggcta gattttgttc agcttgcttt agtttgtcct cttccttgcc caattcctgc
     5041 ttggcttggg taagttgagc actagcctgc tctctctgaa cttgaggaaa caaggctagt
     5101 tgactttctt gagcctgtat acgagcttga gcagctgcta aacgacgctt gccttcctgc
     5161 aaattagtct gagccttgtc aagggtctct tgccccttgt ctagagactc ttgtccttct
     5221 tttttcaaga gttgcagacg taccttgcca ttatctgata aaatttgttc aagctcttcc
     5281 tgatgttgct tagatttttc ttcataagct gatgaaaagg catttaaacc tgctaaatct
     5341 tgatatttca aacgagctat attgtagact ttctgatcaa attgactagg taaaatcacc
     5401 ccataggctg tcagagtccc acttccactt cctgcgtagc ccatatctcg ctgggagagg
     5461 atttcagccg aatccacaaa accagtaatg gtataagtat ggtcttttaa agaggaatga
     5521 ccctcttctt tttctttaaa actaatctcc tgtcccacgc tgtattggcc ttgcaaatga
     5581 gtggccaaag cgatttcctt gtctgactga ggaagtcgtc cctttcttag ctgaaaggtt
     5641 gaaattcgct ctggtttgga gtacagccga atggcatcct gcccattatc catagtcaca
     5701 tctgtcaaat agccaaactc gacctctgcg ccctccgtct gtcttagttc ttcttggtct
     5761 gcttgatcca agccatagtt agacatgact gccaaatcca aggtttgagc agttgttaaa
     5821 taagcattag ctgtcgtctc catgttggga ctggttactt tgaggcctac taaggctaga
     5881 gatcccaaca tcatcaggat caagatggat aaaaaacgcc ccttggagcc tgtgaaggac
     5941 tgaattaagt ccttccaata agtttttcgc ttgatcatgc tagtactcca aactgtcaat
     6001 atcctgagga tgctggttga gcaccacatc cttgacactg gcatcgtgca tatgaatcac
     6061 gcgatcagca atgggcgcca aagctccatt atgagtcacg atgatcaccg tcgctccctt
     6121 ttgacgagac atgtcttgga gaattttcaa aacctgcttg cccgtctgat aatccaaggc
     6181 tccagtcggt tcatcacaaa ggagaatttt aggatttttg gctaccgcgc gtgcaatgga
     6241 gactcgctgt tgctcccctc cagaaagctg ggctggaaag ttatttagac gatgagccag
     6301 acctacatct gtcaagacct gatcaggatt caaggcatct gtcacaattt cagaagccag
     6361 ttccacattt tccttagctg tcagattaga aactagatta taaaactgaa aaacaaaccc
     6421 cacatcattt ctacggtaat tggtgcgctg gtgggaacta taatccgcaa tattaacacc
     6481 atcaatccag atttcccctt catcattggt atccattccc ccaagaaggt taagcactgt
     6541 tgacttgcct gcacctgaag caccaaggat aataaccagc tccccctttt caatctcaaa
     6601 attcacatca cgattggcca caatctccgt gtccccaacc tgataacgct tgtaacagtg
     6661 tttcatctca atataagcca tcagacccac cctctatcaa acaaattata ctcctcgaaa
     6721 atctctcttc aaaccacgtc agcttccatc tgcaacctca aaacactgtt ttgagcaacc
     6781 tgcggctagc ttccttgttt gtgctctttg attttcattg agtattactt cctattatca
     6841 ttataacgct ttttcaacta gttgaaaact gcttatattc ttaaatcctt attaaaaggc
     6901 agtttcaaat tactgcctta taacatcttc ttaaaaataa aattgaacaa gatcaccttc
     6961 tgctgttgcc accgaaatac aatctttccc catgcatttc gcttttattt tttcttgatt
     7021 cattttaatc acactcttct caatatctgg ataagaaact cgcaaatctc ctccactcct
     7081 tgataaaatg gtcaactgta agagtttttt atcttcccag ctcatgctca cttcaaaatg
     7141 tccacgtgcc attaagcctg aaacagaacc tgttgaccaa gcatcaggta gggcagctag
     7201 aggtaccaga taagctgcat gagactggag taacatttct gccatgccac tagtagcacc
     7261 aaaattacca tctatctgaa aaggaggatg gctacaccaa agatttggca aggtggatgt
     7321 ctttaactgc tctgccaata atttatgggc tcgattgcca tctcccaaac gcgcccagag
     7381 attgatctta ttagccttgg accagcctgt gccgccatct ccacgatcat tgaggctagc
     7441 acgcgccgct tcaatatact cttgtccctt gtagctaaag agattgccag gatagagtcc
     7501 cactagatgg gaagcgtgcc ggtgctgggc ctccactttc tcattttgaa aatactgctc
     7561 ttcctcctca taccactccc tgattcgacc agattgagtg atttgcaaag gatttagtaa
     7621 atcagacttc tccttaacct cagtcaacaa gtcctcatcc agtcccaatt cctgagcagc
     7681 ctgaataaaa tcatgaaata actgccaaat cagagattgg tcataggtat tgccaatcga
     7741 aatcggccca tgttctggag aataagacgg agaagacacc caacgctgcg cctgctgatc
     7801 cttatgtaaa aaggcattcc aaaaacgaac cgtttccctc aacatgggat aaattttctc
     7861 cctgagatag tcttggtccc tataaaatga ataggcttca taaacggttt gcatcatcca
     7921 cgcattggca gctggtgacc aaccccaata gtaatcccaa ccaggtgccg tccaaccaaa
     7981 gggagtcgct tgagtatgaa ccaaccaacc attttcctca cctttctgag agacgattcc
     8041 tgcatacttt acagccgcta gacgaccata gacacgcaaa tcatctacat agttgatgac
     8101 cggaaagacc gcctctagga gattggtaac ataggctggc caataattca tctgcagatt
     8161 gacatttaag tgatagtccg aattccaagg aggattgtcg accgcattcc agactccctg
     8221 taggttagct ggtagagcat ctgggcagtc tctggacgaa ctaatcaata aataccgtcc
     8281 atactggaag aacagctcct ccaaagcctg cccttcttgt ggcttataat tttttaacaa
     8341 atcatctgta gtggatgcgt caacatcagc ttccaaatcc aattgaacac gctggaataa
     8401 ggcttggtag tcctcgatat gccttgattt caattgggta tagccctttt ctttagctgt
     8461 gtccaccaag tctatcacct gttgctctaa atctagtttc ttgcgataat tgctagcagg
     8521 attttgggca aaatccgtct tagcggccaa gaagagattg gcataactgg ctcctgatat
     8581 ctgaacccta tctgaccaaa ctctaatatc tccatccgtt tcccaagcta gataactagc
     8641 aaaccgcaga tcattatcct taactcttcc cttcatcaag atatgagaat cagtaatatc
     8701 caacttacac tccttgtaat cagatttttc ctgctcatac ttttcatcag aagccaaatc
     8761 acaggtcaag gatagttcta tagtaaaatc tagagtttcc gccccttcct tagtaaaacg
     8821 ctgaaccaag agatcatctg gaaaactcgc aaaagcttca cgttcaaatc gcgttccctt
     8881 atagacataa gaagtcgtca caagtgcctt actaatattc agctgtctct gatagtccgt
     8941 cacctgagac aaagtcgtac cttgctggct gaactcaatg tgaatatccc caaaagacag
     9001 ataggtccca tattgactcg tttttggccc aattaggtgc tgctcagcca gttccttagc
     9061 cagattgtaa tctctcttct ccaaagcctg ccgaatctca gctaaaaaaa catactgatc
     9121 ctgaagattt ccaccctgat aatctgaact atcaggaagt ggacctccag accagagact
     9181 tttttcatta aattgaatcc gttcagcccc tatacggcca aatacttttg ctcctaaaga
     9241 accattacct atcggtaaag cttcttcttc ccaacccatg taagtggttg aagctggttg
     9301 tttgtaggcc agtacataat cttgtttttt attccttatc atacttccat actaacataa
     9361 aaagcctaga aatcaatcct aggcttacaa ttttttattt tccaaggtag tattcagaaa
     9421 caacgttcaa tttttcgtcg aattcgaata ccaatggtgg gaagttaggg atttccacgt
     9481 ccatgatctc atcatctgac aaacctttga tgtgttttac aagggcacgg attgagttac
     9541 cgtgagctcc tacgaatacg tttttaccat ctttaagagc tggagcgatt ttatcttccc
     9601 agaatggaag agcacgttcc aaagtcactt tcaagttttc agcatctggg ataactgagt
     9661 cgtcaagtga agcgtaacga cggtctgtgt gagctgagtg ctcatcatca cggtccatgt
     9721 ttggaggcaa tacatcgtat gaacgacgcc agatgtgaac ttgctcatca ccaaattgtt
     9781 cagcagcttc agctttattt ttaccagtca aaccaccgta gtgacgttcg ttcaagcgcc
     9841 atgatttttc aactggaacc cacaattggt cagaagcttc aagagccaag ttagttgttt
     9901 tgatagcacg tttcaatact gaagtgtaag cttggtcaaa tttgatacca gcttctttga
     9961 tcaatttacc agcgtcaatc gcttgttgtg tacctttttc agacaaatca acatcagccc
    10021 aaccagtgaa aaggttagct ttgttccatt cagactcacc gtggcgagca aaaaccaatt
    10081 ttaccattag atggattctc ctttaaattt tccgaggttt cccctcgttt atctattcta
    10141 ttttacacaa tttttcacaa aaaagctagt caaaaccaaa aaggaaagga ctgtttgaca
    10201 atgtttggca atcacattgt ttttggttgt ttctattcta tcttcattat ttaacctttt
    10261 tttctgcgca tcgaataatt tttgagttga ctcttttagt ttagtaaacg agtcattatt
    10321 ttccatagct gtgcctttga aaccttcctc agttttagta aaataatcat caaaaatatt
    10381 tttataaaga tctatataat ctgcataagt gcgtattgat tcaatcgcat cgtctgttac
    10441 aaccggtgta tcaaaagtga ttgtttcttt tgaactattg gatgttgcta ctgtcttctc
    10501 atcattactt gttgaagtat tctttgaact ttatgttcca catgcaacta gaagagaaag
    10561 agataataga gctactccta taccgataaa cttttttgtt cttttcatgc taaaatacct
    10621 tttattcttc tgatttgaat ttcttcaatg ttgcaaggaa tagagatcct ccgataatag
    10681 caagaatccc cccaacccat cctaagaatg gaatgagact aacttcacca gaaacaatca
    10741 ttagtacaga cggagctgca cctacacgct tatctccttt atagtaaaca atagcaatga
    10801 taccaagaac aagatttgca atcttcaagg cattcaagag taaggcaaca cctgaaaaag
    10861 cccctgcagt agctcctcca ttaagagttg tagcagctgt atttaccgct gttcccaaca
    10921 agacaaaagg acaaataaga agtaaaattc ctcccacaag accgacgata ccacttgatt
    10981 tcataataaa atctcctttt ttattttttt caaataaaat tgtatcatat ttgcttttta
    11041 aaaaaagtat tttctgatat tataaaataa aaa
//
LOCUS       DAVHIZ010000054        10997 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.056, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000054 DAVHIZ010000000
VERSION     DAVHIZ010000054.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10997)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10997)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10997
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.056"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            231..326
                     /locus_tag="VVO18_001678"
                     /pseudo
     CDS             231..326
                     /locus_tag="VVO18_001678"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(579..1199)
                     /locus_tag="VVO18_001679"
     CDS             complement(579..1199)
                     /locus_tag="VVO18_001679"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000780815.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU5586791.1"
                     /translation="MKLYFVRHGRTLWNQEGRFQGASGDSPLLPESIETLKRLGQYLK
                     EIPFDQIYSSDLPRAVKSAEIIQSQLHTPCSLEIVPNLREWQLGKLEGLKIATLEAIY
                     PQQIQAFRSNLAQFDTRMFGAESLYSTTQRTIQFIKSLKDSPAERILIVGHGANLTAS
                     LRTLLGYKEPLLRKDGGLANASLTIIETHDFETFTLNTWNDTSYQS"
     gene            complement(1199..1681)
                     /locus_tag="VVO18_001680"
     CDS             complement(1199..1681)
                     /locus_tag="VVO18_001680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397917.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoacyl-tRNA deacylase"
                     /protein_id="HEU5586792.1"
                     /translation="MAKKVKIKKTLVEQILSKAAIPHQGIQINALEGELPQGYERDQI
                     FKTLALLGDKTGPIIGIVPITQHLSEKKLAKISGNKKVSMIPQKDLEKTTGYIHGANN
                     PVGIRQKHNYPIFIDKIALDLDRMIVSAGEVGHSIIVAPQDLASFVKADFVDILEDIK
                     "
     gene            complement(1681..2523)
                     /locus_tag="VVO18_001681"
     CDS             complement(1681..2523)
                     /locus_tag="VVO18_001681"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004256605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF368 domain-containing protein"
                     /protein_id="HEU5586793.1"
                     /translation="MLSWLARVIKGIVIALGFILPGISGGVLAAILGIYERMIGFLAH
                     PFKDFKENVLYFIPVAIGMLLGIGLFSYPIEYLLENYQVFVLWSFAGAIIGTVPSLLK
                     ESTRESDRDKIDLAWLWTTFIISGLGLYALNFVVGTLSASFLNFVLAGALLALGVLVP
                     GLSPSNLLLILGLYAPMLTGFKTFDFLGTFFPIGIGAGATLIVFSKLMDYALNNYHSR
                     VYHFIIGIVLSSTLLILIPNAGNAESIQYTGLSLVGYVIIAFFFALGIWLGIWMSQLE
                     DKYK"
     gene            complement(2618..3406)
                     /locus_tag="VVO18_001682"
     CDS             complement(2618..3406)
                     /locus_tag="VVO18_001682"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866725.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 25 protein"
                     /protein_id="HEU5586794.1"
                     /translation="MRKQIHPLILFSFFGIMMFILIINRPLNDSQSFKTKSNIAQALK
                     HLDKPIIDLSGWQRPEEINYDALSQNISGAIVRVHSGAQTTKENDASFINGIDKAYKS
                     HITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKTMSNMN
                     EGVENFRAKLASLGAKNIGIYVGVYFMEEHSIDTGKFTSVWIPSYGSDSGFLESSPKT
                     DLDYDIHQYTSKGKIAGFDHDLDINVISPLKNKEETFRKLFLKP"
     gene            3550..4929
                     /gene="glmU"
                     /locus_tag="VVO18_001683"
     CDS             3550..4929
                     /gene="glmU"
                     /locus_tag="VVO18_001683"
                     /EC_number="2.3.1.157"
                     /EC_number="2.7.7.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000073762.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional UDP-N-acetylglucosamine
                     diphosphorylase/glucosamine-1-phosphate
                     N-acetyltransferase GlmU"
                     /protein_id="HEU5586795.1"
                     /translation="MSNFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQ
                     PEKTVTVVGHKAELVEEVLTGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGD
                     TPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEVLRIVEQKDATD
                     FEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLK
                     DFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEA
                     NVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPN
                     SSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKY
                     KTVIGDNVFVGSNSTIIAPVELGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYAT
                     RLPHHPKNQ"
     gene            4939..5484
                     /locus_tag="VVO18_001684"
     CDS             4939..5484
                     /locus_tag="VVO18_001684"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NUDIX hydrolase"
                     /protein_id="HEU5586796.1"
                     /translation="MEFEEKTLSRKEIYQGPIFKLVQDQVELPEGKGTAQRDLIFHNG
                     AVCVLAVTDEQKLILVKQYRKAIEAVSYEIPAGKLEVGENTAPVAAALRELEEETAYT
                     GKLELLYDFYSAIGFCNEKLKLYLASDLTKVENPRPQDEDETLEVLEVSLEEAKELIQ
                     SGHICDAKTIMAVQYWELQKK"
     gene            5496..5810
                     /locus_tag="VVO18_001685"
     CDS             5496..5810
                     /locus_tag="VVO18_001685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="foldase"
                     /protein_id="HEU5586797.1"
                     /translation="MGKSLLTDEMIERANRGEKISGPPLLDDNEETKILPTSSSRFGY
                     ANPKDHGFSQETLKIQVEPSIHKSRRIENTKRNVFNSKLNKILFAVIFLLILLVLAMK
                     LL"
     gene            5827..6519
                     /locus_tag="VVO18_001686"
     CDS             5827..6519
                     /locus_tag="VVO18_001686"
                     /EC_number="3.2.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="5'-methylthioadenosine/adenosylhomocysteine
                     nucleosidase"
                     /protein_id="HEU5586798.1"
                     /translation="MKIGIIAAMPEELAYLVQHLDNAQEQVVLGNTYHTGTIASHEVV
                     LVESGIGKVMSAMSVAILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDV
                     TAFGYSYGQMAQQPLYFESDKTFVAQIQESLSQLDQNWHFGLIATGDSFVAGNDKIEA
                     IKSHFPEVLAVEMEGAAIAQAAHALNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRS
                     AQVLLTFLKALD"
     gene            6596..7087
                     /gene="rocS"
                     /locus_tag="VVO18_001687"
     CDS             6596..7087
                     /gene="rocS"
                     /locus_tag="VVO18_001687"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000021242.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosome segregation protein RocS"
                     /protein_id="HEU5586799.1"
                     /translation="MSIEMTVSEIAEVLGLSRQAINNRVKELPEEDTDKNDKGVTVVT
                     RSGLIKLEEIYKKTIFEDEPVSEDVKQRELMEILVDEKNAEILRLYEQLKAKDRQLSE
                     KDEQMRIKDRQIAEKDKQLDQQQQLTLQAMKDQENLKLELDQAKEEVQSTKKGFFARL
                     FGG"
     gene            7185..7775
                     /locus_tag="VVO18_001688"
     CDS             7185..7775
                     /locus_tag="VVO18_001688"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399240.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3'-5' exonuclease"
                     /protein_id="HEU5586800.1"
                     /translation="MERLEDYIAFDLEFNQHEGQKHLIQVSAVRFRDGREIDAYDSYV
                     HTSVPLKSFINGLTGITAETLKDAPPVEKVLEEFQEFVGSLLMIGYNAAKSDLPILAE
                     YGLDYSQQYKVDLYDEAFERRSSDLHGIANLKLQTVASFLGFQGQSHNSLEDARMTAR
                     VYESFLESDQARELLETESSLSNNPFGGLDLSQLFD"
     gene            7784..9547
                     /locus_tag="VVO18_001689"
     CDS             7784..9547
                     /locus_tag="VVO18_001689"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000801733.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="HEU5586801.1"
                     /translation="MKPEKPKKLGLKQIYLNLDKILFLFFLIFMIVEYLWVPFNSWLA
                     SFLLDQTGYLFISYNNVLAILTHSPLISLAFLALIVINLLVAYFQIGLLFIGARHLLY
                     NEKRRLIEYIRKVFHESFGFMKKLTCAKALFIFFYIAMLFPFIRKMLKIYYLNKIVIP
                     EFIQAYLEDKYWMWWLSILLLSLIFLYVSVRLMFALPKIVYDQLTVREAVMFSLEKTK
                     KRVTFYAWNLFYILLKAHLLFYLPLIPLLLAQTLVDDITQRESLILGILNFVVIKNLY
                     YMALTYFLVKFVSFLTGKELDMLPRREKDHIVRWGVMTCASLFFALEGYIYLEAPMVH
                     LPQLISHRGVSNANGIQNTVESLETTAQLKPDLVETDVQETKDGQFVMMHDANLKNLA
                     GINKSPQDLNLEELKGIDIFENGYQTKISSFEDYLSRANELGQKLLIEIKTSKKDSPD
                     MMNRFLARYAAKLKIYGHQIQSLDYHVVEKVRQYDAELPVYFIMPYNSVFPKTRATGY
                     TMEYSTLDEYFVSKLWTTDQKLYVWTVNDSEAISKSLHLGVDGVITDDLEKVQREIEV
                     AQEDPEYTDLLLKKALEFFEF"
     gene            complement(9649..10975)
                     /locus_tag="VVO18_001690"
                     /pseudo
     CDS             complement(9649..10975)
                     /locus_tag="VVO18_001690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
BASE COUNT         3394 a         1889 c         2350 g         3364 t
ORIGIN      
        1 gtagttcatg tacacctgat atgatgcgtt ttataatttt aaagactttt tgaccagcct
       61 cattttttta acttgatact cagtgaaaag caaagattaa actaggaagc tagctgtagg
      121 ctgctcaaag aacagctttg aggttgcaga taaaacttgt gaggtaacca acatatataa
      181 tgtgaagctg acgtggtttg aatagatttt agaagggtat gagtctggaa gttttaatgg
      241 ataatgcaag attccataga atgggtaagc tagagttctt atgtgaagag tttgggcata
      301 aacttttacc ttttcctccc tactcatctt agtatagaaa agtgaatcta aaatagtaca
      361 taactgcttc taaaacattc ttataaattg atttaaattc tcaaatcata ttattcagtt
      421 cttatttcat tttgctctac aatcctgttg agaagacacg tgttcatatc aaaaaggtat
      481 tggcaagttg caataccttt ttacaaggtt cttttgtctt atttttgttt caactgacta
      541 tatctcctat ggttctagtt cagaaggcta ggctataatt atgattgata agaagtatca
      601 ttccaagtat tgagagtgaa tgtttcaaaa tcatgggttt ctataatggt caggctggca
      661 tttgctagac cgccatcttt acgaagaagt ggttctttat agcctaggag agtacgaaga
      721 ctggcagtaa gattggcgcc gtgtccgaca attagaatac gctcagctgg actatctttt
      781 aatgatttga taaattggat ggtccgctga gttgtactat agagggattc ggctccgaac
      841 attcgagtgt caaattgagc aagatttgaa cgaaaagcct ggatttgttg cgggtaaata
      901 gcttccaggg ttgcaatttt caaaccttct aacttcccaa gttgccattc acggagatta
      961 ggaacgattt ctaaagaaca gggggtatgg agttgacttt ggataatctc agcagatttg
     1021 accgctcgag gtaaatcact tgaataaatc tgatcaaaag gaatttcctt gagatactgg
     1081 ccaagtcgtt ttagggtttc aatggattca ggaagaagag gagaatcacc gctagcacct
     1141 tgaaaacgac cttcttggtt ccagagggta cgaccgtggc ggacaaagta gagtttcatt
     1201 acttgatgtc ctccaaaata tctacaaagt ctgcctttac aaagctagcc aagtcttgtg
     1261 gcgcgacgat aatgctgtgt ccgacttcgc ctgcagagac aatcattcga tccaaatcta
     1321 gagcaatttt atcgataaaa atgggataat tgtgtttctg acgaattccg acaggattat
     1381 tggctccatg aatgtaacca gttgtttttt ctaagtcctt ttgtggaatc atgctcactt
     1441 ttttattgcc agaaatttta gctagtttct tttcagacaa gtgctgagtg atagggacaa
     1501 ttccgataat cggtccggtc ttgtctccca aaagcgccaa ggttttgaaa atctgatctc
     1561 gttcataacc ttgaggaagc tctccttcta gggcattgat ttgaatcccc tgatgaggga
     1621 tagctgcttt agataggatt tgttccacca atgttttttt gattttaact ttttttgcca
     1681 ttatttatat ttatcctcca attgactcat ccaaatacca agccagattc ccagcgcaaa
     1741 gaagaaggcg atgatgacat aaccgacaag tgaaagtcct gtgtattgga tactttcagc
     1801 gtttcctgca tttggaatta agatcaaaag ggtacttgat aggacgatac cgatgatgaa
     1861 atgatagacg cgtgagtggt agttgtttaa ggcataatcc atcaattttg aaaaaacgat
     1921 gagagttgca cctgcaccaa ttccaatcgg aaagaaggtt cccaagaaat caaaagtttt
     1981 aaaaccagtc aacataggag catatagtcc caaaatcaaa agtaaatttg atgggctgag
     2041 gccaggaacc aagacgccaa gggccaatag tgcgcctgct aggacgaagt taagaaagct
     2101 ggcgcttaag gttccaacga caaaatttaa ggcatagagt cctaatccag aaatgataaa
     2161 ggttgtccat aaccaagcta aatcaatctt gtctcggtca gattctcgag ttgattcttt
     2221 gaggaggcta ggaactgtac cgataatagc tcccgcaaag ctccataata caaaaacctg
     2281 ataattttca agcaggtatt caatcgggta ggaaaataag ccgattccca gaagcatacc
     2341 gatggcaact ggaataaagt acaaaacatt ttctttaaag tctttaaagg gatgggccag
     2401 aaagccaatc attcgttcat agattcctaa gattgctgct agaacccctc cggaaattcc
     2461 cggtaggata aatccaagag caattacaat ccctttaata acgcgtgcta accatgagag
     2521 catatatttc ctccaactat ttctatttca aaaaatcctt actatattgt atcacaatca
     2581 gacacaaaaa gaaaaagcaa atgataaaca aatgctttta aggttttaaa aaaagttttc
     2641 gaaaggtttc ttctttattt tttaagggag agataacgtt gatatctaaa tcgtggtcaa
     2701 agccggcaat ttttccttta gatgtgtatt ggtgaatatc ataatctaaa tcagttttag
     2761 gactgctctc caaaaatcct gagtctgagc cgtaggacgg aatccaaaca gaggtaaact
     2821 tgcctgtatc aatactgtgt tcttccatga agtagacacc aacgtagatg ccgatgtttt
     2881 tagcacctag tgatgctagt tttgctcgaa agttttcgac accttcgttc atattagaca
     2941 tggttttgtc ttccacgtca agccaatagt aactagggct gtaaggagag gcagcattgt
     3001 agaaaacttc ggcagccttt tccatttctt ggacactttt tccagctaca taagcgtaga
     3061 cagcaactgg gacattccgc ttttgaagtt cagtgatatg actcttatag gccttgtcta
     3121 ttccattgat aaatgaagca tcattttctt ttgttgtttg agcaccactg tgaacacgaa
     3181 caatagcacc tgaaatattt tgtgagaggg catcgtagtt gatttcctca ggacgctgcc
     3241 agccagagag gtcaataatc ggtttgtcta agtgtttcaa agcctgtgct atattggatt
     3301 ttgttttaaa cgattggctg tcattaagtg ggcgattgat gattaaaatg aacatcataa
     3361 tcccaaaaaa actaaataaa ataagtggat gaatttgttt tctcatatct tataagtcta
     3421 ccctaaaaat caaaaaaaat caaaaaaatg ggttaaggaa gagactttag agcatttttt
     3481 cattcaagag tgcggaatga tttgaaatat ggtataataa aagggaattt ctacagaaaa
     3541 gagaagatta tgtcaaattt tgccattatt ttagcagcgg gtaaagggac tcgcatgaaa
     3601 tctgatttgc caaaagtttt gcacaaggtt gcgggtattt ctatgttgga acatgttttc
     3661 cgtagtgtgg gagctatcca acctgaaaag acagtaacag ttgtaggaca caaggcagaa
     3721 ttggttgagg aggtcttgac tggacagaca gaatttgtga ctcaatctga acagttggga
     3781 actggtcatg cagttatgat gacagaacct atcttagaag gtttgtcagg acacaccttg
     3841 gtcattgcag gagatactcc tttaatcact ggtgaaagct tgaaaaactt gattgatttc
     3901 catatcaatc ataaaaatgt ggccactatc ttgactgctg aaacggataa tccttttggc
     3961 tatggacgaa ttgttcgtaa tgacaatgct gaggttcttc gtattgttga gcagaaggat
     4021 gctacagatt ttgaaaagca aatcaaggaa atcaacactg gaacatacgt ctttgacaac
     4081 gagcgtttgt ttgaggcttt gaaaaatatc aataccaata acgctcaagg cgaatactat
     4141 attacagacg tcattggtat tttccgtgaa actggtgaaa aagttggcgc ttatactttg
     4201 aaagattttg atgaaagtct tggggtaaat gaccgtgtgg cgcttgcgac agctgagtca
     4261 gttatgcgtc gtcgcatcaa tcataaacac atggtcaacg gtgttagctt tgtcaatcca
     4321 gaagcaactt atatcgatat tgatgttgag attgctccgg aagttcaaat cgaagccaat
     4381 gttaccttga aagggcaaac gaaaattggt gctgagactg ttttgacaaa tggtacttat
     4441 gtagtggaca gcactatcgg agcaggagcg gtcattacca attctatgat tgaggaaagt
     4501 agtgttgcag acggtgtgac agtcggtcct tatgctcaca ttcgtccaaa ttcaagtctg
     4561 ggtgcccaag ttcatattgg taactttgtt gaggtgaaag gatcttcaat cggtgagaat
     4621 accaaggctg gtcatttgac ttatatcgga aactgtgaag tgggaagcaa cgttaatttc
     4681 ggtgctggaa ctattacagt caactatgac ggcaaaaaca aatacaagac agtcattgga
     4741 gacaatgtct ttgttggttc aaattcaacc attattgcac cagtagaact tggtgacaat
     4801 tccctcgttg gtgctggttc aactattact aaagacgtgc cagcagatgc tattgctatt
     4861 ggtcgcggtc gtcagatcaa taaagacgaa tatgcaacac gtcttcctca tcatcctaag
     4921 aaccagtagg agcctatcat ggagtttgaa gaaaaaacgc ttagccgaaa agaaatctat
     4981 caaggaccaa tatttaaact ggtccaagat caggttgaat taccagaagg caagggaact
     5041 gcccaacggg atttgatttt ccacaatggg gctgtctgtg ttttagcagt aacggatgaa
     5101 caaaaactta tcttggtcaa gcagtaccgc aaagctatcg aggcagtctc ttacgaaatt
     5161 ccagccggaa aattggaagt aggagaaaac acagcccctg tggcagctgc ccttcgtgaa
     5221 ttagaggaag aaacagccta tacagggaaa ttagaactct tgtacgattt ttattcagct
     5281 attggctttt gtaatgagaa gttaaaacta tatttagcaa gcgatttaac aaaagtggaa
     5341 aatccgcgtc cgcaggatga ggatgaaacc ttggaagtcc ttgaagtgag cttagaagaa
     5401 gcgaaagaat taatccaatc aggtcatatt tgtgatgcca agacaattat ggctgttcag
     5461 tattgggagt tgcagaaaaa atagaggagg tcagtatggg taaatcttta ttaacggatg
     5521 aaatgattga aagagctaat agaggcgaaa aaatttcagg tcctcctttg ctagatgata
     5581 atgaggaaac taagatttta ccaacctctt cttcccgttt tggttatgcc aatcctaagg
     5641 atcatggttt tagccaggaa accttgaaga ttcaggtcga accatctatt cataaaagcc
     5701 gtcgtattga aaataccaag agaaatgtct tcaattctaa gttgaataaa atcttatttg
     5761 cggtcatttt tctcttgatt ttgcttgttt tagcaatgaa acttttgtaa tagaaaagga
     5821 attgaaatga aaataggaat tattgctgct atgccagaag aactggctta tctggtccag
     5881 catttagata atgcccagga gcaagttgtt ttggggaata cctatcatac aggaaccatt
     5941 gcttctcatg aagtcgttct tgtagaaagt ggaattggta aggtcatgtc tgctatgagt
     6001 gtggcgattt tggctgatca tttccaggtg gatgccctta ttaatacggg ttcagctggg
     6061 gcagtagcag aaggtatcgc tgttggggat gtcgtgattg ctgacaaatt agcctatcat
     6121 gacgtggatg tcacagcttt tggctattct tatggacaaa tggcgcaaca accgctttat
     6181 ttcgaatcag acaaaacctt tgttgctcaa atccaagaga gtttatctca attggaccaa
     6241 aactggcatt ttggtttgat tgctacagga gatagttttg ttgcaggaaa tgacaagata
     6301 gaagcgatta agtcccattt cccagaagtt ttagccgtgg agatggaggg ggcagctatt
     6361 gctcaagcag cgcatgccct caatctccca gtcttagtca tcagagctat gagtgacaat
     6421 gccaaccatg aagcaaacat cttttttgat gagtttatta tcgaagctgg acgtcgctct
     6481 gcccaagtct tgttgacctt tttgaaggct ttagattaag cggaaatttg acagtttttc
     6541 tagcttatga taagatttaa gtaaagaaaa gctagaaaac gtttcagagg atattatgag
     6601 tattgaaatg accgtcagtg agattgcaga ggtcttagga ttatctcgcc aagcaatcaa
     6661 taaccgtgtc aaagaattac cagaagaaga cacagataaa aatgacaaag gggtaacagt
     6721 tgttaccaga agtggcttga ttaagctaga agaaatctat aaaaaaacga tttttgaaga
     6781 tgagcctgtc agtgaagatg tcaaacaacg tgaactgatg gagattctag tggatgagaa
     6841 gaatgcagaa attcttcgtc tttatgaaca attaaaagcc aaggatcgtc agttatcaga
     6901 aaaagacgag cagatgcgta tcaaagaccg tcagattgct gagaaagaca aacaattaga
     6961 tcagcaacaa caattgaccc ttcaagccat gaaggatcaa gaaaatctta agctagagct
     7021 ggaccaagca aaagaagaag tccaatccac taaaaaaggc ttttttgctc gtttatttgg
     7081 aggataatca aggagctgtt taggttaaat gctaacctga tggcttcttt tgtttgtgaa
     7141 tagtatagtt gattagaaca gagacagtag aggagaggta cagaatggaa cgattagaag
     7201 attacattgc ttttgactta gaatttaatc agcacgaagg acaaaaacac ttgattcaag
     7261 tatcggcagt gcgttttaga gatggtcggg aaatcgatgc ctatgattcc tatgttcata
     7321 ccagcgtccc tctaaaaagc tttatcaatg gtttgaccgg gattacagct gagaccttaa
     7381 aagatgctcc tccagttgag aaagtcttag aagaattcca agagtttgtg ggttctttgc
     7441 tgatgatagg ctacaatgct gctaaaagtg atttacctat tttagcagag tatggtttag
     7501 actatagcca acagtacaag gtggatttgt atgatgaagc ttttgaacgt cggagttcag
     7561 atttacatgg tattgccaat ctcaaattgc aaactgttgc ctcatttctt ggatttcaag
     7621 gtcagtctca taatagttta gaggatgctc ggatgacggc gcgtgtttac gaatccttct
     7681 tagagtcgga tcaagctagg gaattgttag agacagaaag tagcttatca aacaatcctt
     7741 ttggtggctt ggacttgtct caattatttg actaggagtg cctatgaaac ctgaaaaacc
     7801 taaaaaattg ggtcttaaac agatttacct caatcttgat aaaatcctct ttctattttt
     7861 cttgattttt atgatagtgg agtatttgtg ggtaccattc aattcatggt tggctagctt
     7921 cttattagat cagacaggtt atctttttat ttcctataac aatgtcttag ccatccttac
     7981 tcattctcca ttgattagtc tagctttttt agccttgatt gtaattaacc ttctggttgc
     8041 ttattttcaa ataggactcc tctttattgg tgctcgtcat ctcctctata atgaaaagcg
     8101 aaggctaatt gagtatatcc gcaaggtttt ccatgaaagt tttggattta tgaaaaagct
     8161 aacttgcgct aaagccttgt ttatcttttt ctatatagct atgctttttc cttttatacg
     8221 gaaaatgctg aagatttatt atcttaataa aatcgtcatt ccagagttta tccaagctta
     8281 tttagaagat aaatattgga tgtggtggct gagcatccta cttctatctc ttatctttct
     8341 ctatgtctct gtcagattga tgtttgccct tccgaagatt gtatatgatc agctgactgt
     8401 tcgagaagca gtgatgttta gcttggagaa aaccaagaag agagttactt tttatgcttg
     8461 gaatttattt tacatcttgc tcaaagcaca tttattattt tatcttcctt tgattccttt
     8521 attattggct caaactttgg tagatgatat cactcagaga gagtctctga ttcttggtat
     8581 tttgaatttt gtcgtgatta aaaatctata ttatatggct ctgacttatt ttttggttaa
     8641 atttgtttca tttttgacag gaaaggagct ggatatgctt cctaggagag aaaaagatca
     8701 catcgtgcga tggggtgtca tgacttgtgc cagtcttttc tttgccttag aaggttatat
     8761 ttatctggag gctcccatgg ttcatctacc tcaacttatt tctcaccgag gggtttccaa
     8821 tgcaaatggg attcaaaata cagtagagtc cttggaaact acagcacaac tcaaaccaga
     8881 cttggtggag acggacgtgc aggaaacaaa agatgggcag tttgtcatga tgcatgatgc
     8941 taacttgaaa aatctagcag gtatcaataa aagtcctcaa gacttaaact tggaggagct
     9001 taaagggatt gatatttttg aaaatggcta ccagactaaa atttcaagct ttgaagatta
     9061 tctcagtcga gccaacgaac ttggtcaaaa attactaatt gaaattaaaa ccagtaaaaa
     9121 agatagtcca gacatgatga accgcttttt agcccgttat gctgcaaagc tcaagattta
     9181 tggacatcaa atccagtctt tagactacca tgttgtcgaa aaagtaagac agtatgatgc
     9241 cgaactgcca gtttatttca tcatgcccta caattctgtc tttcctaaaa caagagcgac
     9301 aggatatact atggagtact caaccttgga tgaatatttt gtaagcaaac tatggacaac
     9361 ggatcagaaa ctttatgtct ggactgtcaa tgattcagaa gctatcagca aatctcttca
     9421 cttaggagta gatggagtga ttacagatga tttggaaaaa gttcagcggg aaatagaagt
     9481 agcccaagaa gatccagaat atacggattt gctcttgaaa aaagcattgg aattctttga
     9541 attttagtaa taaaaaagag gaacggttgt tcctcccatg ataggtaagt attcttgtga
     9601 atgcttgctt ttttggctct ttgtcaactg tagtgggttg aaaaaaagct aagcttgaga
     9661 aaggacaaat tttgtccttt cttttttgat attcagagcg ataaaaatcc gttttttgaa
     9721 gttttcaaag ttccgaaaac caaaggcatt gcgcttgata agtttgatga gattattggt
     9781 cgcttccagt ttggcattag aatagtgtag ttgaagggcg ttgacaatct tttctttatc
     9841 tttgaggaag gttttaaaga cagtctgaaa aataggatga acctgcttaa gattgtcctc
     9901 aataagtccg aaaaatttct ctggttcctt attctggaag tgaaaaagca agagctgata
     9961 gagttgatag tggtgtttca agtcttccga ataactcaaa agcttgttta aaatctcttt
    10021 attggttaag tgcatacgaa aagtaggacg ataaaaacgt ttatcactca gtttacggct
    10081 atcctgttga atgagtttcc agtagcgctt gatagccttg tattcatggg attttcgatg
    10141 aaactgattc atgatttgga cacgcacacg actcatagca cggctaagat gttgtacaat
    10201 gtgaaagcga tcaagaacga ttttagcatt cgggagtgaa acagtctggg agactgtttc
    10261 agcctgagcc tagaaatttg aaagcgaagc tgtttagcca agtcatagta aggactaaac
    10321 atatccatcg taatgatttt cacttgacaa cgaacggctc tatcgtagcg aagaaagtga
    10381 tttcggatga cagcttgtgt tctgccttca agaacagtga taatattaag attatcaaaa
    10441 tcttgcgcaa taaagctcat ctccatctcc cgattgaaac agtcactccc cggactgttt
    10501 caacgtccca agacataatc ttaggcagat ttctaaaatt acactcaaag tggaagtcat
    10561 tgagctttcg aatgacagtt gaagttgaga tggaaagctg atgggcaata tcagtcatag
    10621 aaatcttttc aattaacttt tgagcaatct tttggttgat gatacgaggg atttggtgat
    10681 ttttctttac caggggagtc tcagcaacca tcatttttga acagtgatag cacttgaaac
    10741 agcgttttct aaggagaatt ctagtaggta taccagtcgt ttcaagataa ggaattttag
    10801 aaggtttttg aaagtcatat ttcttcaatt gatttccgca ctcagggcaa gatggggcgt
    10861 cgtagtccag tttggcgatg atttccttgt gtgtatcctt attgatgatg tctaaaatct
    10921 ggatattagg gtctttaatg tctagtaatt ttgtgataaa atgtaattgt tccatatgaa
    10981 tctttctaat gatggtt
//
LOCUS       DAVHIZ010000055        10969 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.057, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000055 DAVHIZ010000000
VERSION     DAVHIZ010000055.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10969)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10969)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10969
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.057"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            107..1408
                     /gene="pspC"
                     /locus_tag="VVO18_001691"
     CDS             107..1408
                     /gene="pspC"
                     /locus_tag="VVO18_001691"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000477101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal surface protein PspC,
                     LPXTG-anchored form"
                     /protein_id="HEU5586802.1"
                     /translation="MFKSNHERRMRYSIRKFSVGVASVAVASLFMGSVVHATEKEGST
                     QAATSFNRGNGSQAEQRGELDLERDKAMKAVSEYVGKMVRDAYVKSDRKRHKNTVALV
                     NQLGNIKNRYLNEIVHSTSKSQLQELMMKSQSEVDEAVSKFEKDSFSSSSSGSSTKPE
                     TPQPENPEHQKPTTPAPDTKPSPQPEGKKPSVPDINQEKEKAKLAVATYMSKILDDIQ
                     KHHLQKEKHRQIVALIKELDELKKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFK
                     KGLTQDTPKEPGNKKPSAPKPGMQPSPQPEVKPQLEKPKPEVKPQLEKPKPEVKPQLE
                     KPKPEVKPQLEKPKPEVKPQLEKPKPDNSKPQADDKKPSTTNNLSKDKQPSNQASTNE
                     KATNKPKKSLPSTGSISNLALEIAGLLTLAGATILAKKRMK"
     gene            complement(1627..2607)
                     /gene="dusB"
                     /locus_tag="VVO18_001692"
     CDS             complement(1627..2607)
                     /gene="dusB"
                     /locus_tag="VVO18_001692"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006147761.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="HEU5586803.1"
                     /translation="MTNLNTPFMIGNIEIPNRTVLAPMAGVTNSAFRTIAKELGAGLV
                     VMEMVSDKGIQYNNEKTLHMLHIDEGENPVSIQLFGSDEDSLARAAEFIQENTKTDIV
                     DINMGCPVNKIVKNEAGAMWLKGPDKIYSIINKVQSVLDIPLTVKMRTGWADPSLAVE
                     NALAAEAAGVSALAMHGRTREQMYTGHADLETLYKVAQALTKIPFIANGDIRTVQEAK
                     QRIEEVGADAVMIGRAAMGNPYLFNQINHYFETGEILPDLTFEDKMKIAYEHLKRLIN
                     LKGENVAVREFRGLAPHYLRGTSGAAKLRGAISQASTLAEIEALLQLEKV"
     gene            complement(2594..3466)
                     /gene="hslO"
                     /locus_tag="VVO18_001693"
     CDS             complement(2594..3466)
                     /gene="hslO"
                     /locus_tag="VVO18_001693"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357853.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hsp33 family molecular chaperone HslO"
                     /protein_id="HEU5586804.1"
                     /translation="MDKIIKTISESGAFRAFVLDSTETVRTAQEKHQTQASSTVALGR
                     TLIASQILAANEKGNTKLTVKVLGSSSLGAIITVADTKGNVKGYVQNPGVDIKKTATG
                     EVLVGPFVGNGQFLVITDYGTGNPYNSITPLISGEIGEDLAFYLTESQQTPSAVGLNV
                     LLDEEDKVKIAGGFLVQVLPGAKKEEIARFEKRIQEMPAISTLLESDDHIEALLKAIY
                     GDEAYKRLSEEEIRFQCDCSHERFMNALASLPSSDLQEMKEEDHGAEITCQFCQTTYN
                     FDEKDLEELIRDKS"
     gene            3631..5058
                     /locus_tag="VVO18_001694"
     CDS             3631..5058
                     /locus_tag="VVO18_001694"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000280545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5586805.1"
                     /translation="MYLGDLMEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLT
                     KYVTLLNDKALDSGLELTIHSEDENLRLSIGAATKGRDIRSLFLDSAVKYQILVYLLY
                     HQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLF
                     RKVWSSQEWEGHMQKPERKQEIANLEEICGASLSAGQKLDLVLWAHISQQRLRVNACQ
                     FQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLH
                     TMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQD
                     RYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENG
                     GQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKE
                     QTPVYYLKNDLDMEDLAGIRQLLFT"
     gene            5217..6725
                     /gene="glpK"
                     /locus_tag="VVO18_001695"
     CDS             5217..6725
                     /gene="glpK"
                     /locus_tag="VVO18_001695"
                     /EC_number="2.7.1.30"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000076796.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerol kinase GlpK"
                     /protein_id="HEU5586806.1"
                     /translation="MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAG
                     WVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAI
                     VWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEGAQERAEKGE
                     LLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEV
                     RSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNT
                     GEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYA
                     RDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDI
                     IDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGL
                     SVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD"
     gene            6767..8593
                     /gene="glpO"
                     /locus_tag="VVO18_001696"
     CDS             6767..8593
                     /gene="glpO"
                     /locus_tag="VVO18_001696"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865074.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 1 glycerol-3-phosphate oxidase"
                     /protein_id="HEU5586807.1"
                     /translation="MEFSKKTRELSIKKMQERTLDLLIIGGGITGAGVALQAAASGLE
                     TGLIEMQDFAEGTSSRSTKLVHGGLRYLKQFDVEVVSDTVSERAVVQQIAPHIPKSDP
                     MLLPVYDEDGATFSLFRLKVAMDLYDLLAGVSNTSAANKVLSKDQVLERQPNLKKEGL
                     VGGGVYLDFRNNDARLVIENIKRANQDGALIANHVKAEGFLFDESGKITGVVARDLLT
                     DQVFEIKARLVINTTGPWSDKVRNLSNKGTQFSQMRPTKGVHLVVDSSKIKVSQPVYF
                     DTGLGDGRMVFVLPRENKTYFGTTDTDYTGDLEHPKVTQEDVDYLLGIVNNRFPESNI
                     TIDDIESSWAGLRPLIAGNSASDYNGGNNGTISDESFDNLIATVESYLSKEKTREDVE
                     SAVSKLESSTSEKYLDPSAVSRGSSLDRDDNGLLTLAGGKITDYRKMAEGAMERVVDI
                     LKAEFDRSFKLINSKTYPVSGGELNPANVDSEIEAFAQLGVSRGLDSKEAHYLANLYG
                     SNAPKVFALAHSLEQAPGLSLADTLSLHYAMRNELALSPVDFLLRRTNHMLFMRDSLD
                     SIVEPVLDEMGRFYDWTEEEKATYRADVEAALANNDLAELKN"
     gene            8663..9367
                     /locus_tag="VVO18_001697"
     CDS             8663..9367
                     /locus_tag="VVO18_001697"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004262009.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aquaporin family protein"
                     /protein_id="HEU5586808.1"
                     /translation="MMNELFGEFLGTLILILLGNGVVAGVVLPKTKSNSSGWIVITMG
                     WGIAVAVAVFVSGKLSPAHLNPAVTIGVALKGDLPWASVLPYILAQFAGAMLGQILVW
                     LQFKPHYEAEENAGNILATFSTGPAIKDTVSNLISEILGTFVLVLTIFALGLYDFQAG
                     IGTFAVGTLIVGIGLSLGGTTGYALNPARDLGPRIMHSILPIPNKGDGDWSYAWIPVV
                     GPVIGAALAVLVFSLF"
     gene            9664..9867
                     /locus_tag="VVO18_001698"
     CDS             9664..9867
                     /locus_tag="VVO18_001698"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586809.1"
                     /translation="MPKWSNPDYVNELDPKIVDMLVEFHKSQGTLETPEAQAEIAQKR
                     EEIEQRRAELEGKKQELLNRLNK"
     gene            complement(9954..10541)
                     /locus_tag="VVO18_001699"
     CDS             complement(9954..10541)
                     /locus_tag="VVO18_001699"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808792.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586810.1"
                     /translation="MFVFADDSLSANSKVVSGEAQFENGSSVRFGDTQVNILSDEVLE
                     VVNPDGSVDTIERRADGVYINGAFYMAYQKNEIDLNISFRSYDPNVWNYVNTIHGNKQ
                     ANTFANFMTGAGISYMIGRIGALLGGPWGAIIGGAYFSIQAYQSYLDSQSPYPYYITS
                     TYIHVAQRKWKFITEYYRNSNYTGYVKTVTTYVNF"
BASE COUNT         3334 a         2146 c         2429 g         3060 t
ORIGIN      
        1 tttacccact acaaatatta tagagccaaa taatgtagca aatttcatat acaattcata
       61 ttagcaggat atactgtagt taattaaaat tatggagaat atagacatgt ttaaatcaaa
      121 tcatgagcga agaatgcgtt attccattcg taaatttagt gtaggagtag ctagcgtagc
      181 tgttgccagt ctttttatgg gaagtgttgt acatgcgaca gagaaagagg gaagtaccca
      241 agcagccact tcttttaata ggggaaatgg aagtcaggca gaacaacgtg gagaactcga
      301 tttagaacga gataaggcaa tgaaagcggt cagtgaatat gtaggaaaaa tggtgagaga
      361 tgcctatgta aaatcagata gaaaacgaca taaaaatact gtagctctag ttaaccagtt
      421 gggaaacatt aagaacaggt atttgaatga aatagttcat tcaacctcaa aaagccaact
      481 acaggaactg atgatgaaga gtcaatcaga agtagatgaa gctgtgtcta aatttgaaaa
      541 ggactcattt tcttcgtcaa gttcaggatc ctccactaaa ccagaaactc cgcagccgga
      601 aaatccagag catcaaaaac caacaactcc agctccggat accaaaccaa gccctcaacc
      661 agaaggcaag aaaccaagcg taccagacat taatcaggaa aaagaaaaag ctaagcttgc
      721 tgtagcaacc tacatgagca agattttaga tgatatacaa aaacatcatc tgcagaaaga
      781 aaaacatcgt cagattgttg ctcttattaa ggagcttgat gagcttaaaa agcaagctct
      841 ttctgaaatt gataatgtaa ataccaaagt agaaattgaa aatacagtcc acaagatatt
      901 tgcagacatg gatgcagttg tgactaaatt caaaaaaggc ttaactcagg acacaccaaa
      961 agaaccaggt aacaaaaaac catctgctcc aaaaccaggt atgcaaccaa gtcctcaacc
     1021 agaggttaaa ccgcagctag aaaaaccaaa accagaggtt aaaccgcagc tggaaaaacc
     1081 aaaaccagag gttaaaccgc agctggaaaa accaaaacca gaggttaaac cgcagctgga
     1141 aaaaccaaaa ccagaggtta aaccgcagct agaaaaacca aaaccagata atagcaagcc
     1201 acaagcagat gataagaagc catcaactac aaataattta agcaaggaca agcaaccttc
     1261 taaccaagct tcaacaaacg aaaaagcaac aaataaaccg aagaagtcat tgccatcaac
     1321 tggatctatt tcaaatctag cacttgaaat tgcaggtctt cttaccttgg cgggggcaac
     1381 cattcttgct aagaaaagaa tgaaatagtg attgattcat tcaaaaatgt ttgtaaaaag
     1441 tattcgactt aaaagaaaag agtctgggat aaaaagattt tgattttagg aattctttat
     1501 tataaatttt taaaatcgat agattagaca aaaaagcgaa caagacagaa ttctgagtgt
     1561 cagataactg attttgttcg ctttttatat ttaatattat acttttgtcc taggctcttt
     1621 tttgcattat actttttcca attgcaagag agcttcaatc tctgctaggg tgctagcttg
     1681 cgaaatggct ccacggagtt tggcagcgcc agatgttcca cggagatagt gaggagcgag
     1741 gccgcggaat tcacgaactg cgacgttttc tcctttgagg ttaatcaatc gtttcaagtg
     1801 ttcgtaggcg atcttcatct tgtcttcaaa tgtcaaatca ggtaggattt ctcctgtttc
     1861 aaagtaatgg ttgatttggt tgaagaggta aggatttccc atggcagctc ggccaatcat
     1921 gactgcgtca gcaccaactt cttcgatgcg ttgcttggct tcttggacag tacggatatc
     1981 accgttggcg atgaatggaa tcttggttag agcttgggca accttgtaaa gggtctcaag
     2041 gtccgcgtgg ccagtataca tttgttcacg ggtacggcca tgcatggcga gggcagaaac
     2101 acctgcagcc tcagcagcga gggcattttc tactgcaaga gatgggtccg cccagccggt
     2161 acgcattttg acagtaagtg ggatatcaag gacagactgg accttgttga tgatagagta
     2221 gatcttgtca ggacccttga gccacatagc accagcttcg ttcttcacga ttttgttgac
     2281 agggcagccc atgttgatat cgacgatatc ggtcttggtg ttttcttgga tgaattctgc
     2341 tgcgcgtgct aggctgtctt catcgctacc aaaaagttgg atagagacag ggttttcgcc
     2401 ctcatcgata tgaagcatgt gcagggtttt ttcgttgttg tattggattc ccttgtcaga
     2461 gaccatttcc attacaacga gtccagctcc aagctctttt gctatggtac gaaaggctga
     2521 gttggtcacg ccagccatag gcgctaaaac ggtacgattg ggaatctcaa tattgccaat
     2581 cataaaaggt gtattaagat ttgtcacgaa tgagttcctc caggtccttt tcatcaaagt
     2641 tgtaagtagt ttggcagaat tgacaagtga tttctgcacc gtggtcttcc tctttcattt
     2701 cctgtaagtc tgagcttgga aggctggcaa gagcgttcat aaagcgttca tggctacagt
     2761 cacattggaa acggatttct tcttcagaaa gacgcttgta ggcttcgtcc ccgtagatag
     2821 ccttgaggag ggcttcgata tggtcgtcgc tttcgagaag agtagagata gctggcattt
     2881 cttggatgcg tttttcaaag cgagcaatct cttctttctt ggctcctggc aagacttgaa
     2941 ctaggaaacc acctgcaatc ttgaccttgt cttcctcgtc caaaaggaca ttgaggccga
     3001 ccgctgaagg cgtttgttgg ctttcagtaa ggtaaaaggc aaggtcttca ccgatttctc
     3061 cagagatgag gggagttata gagttgtaag gatttccagt accgtagtct gtgataacga
     3121 ggaattgacc atttccaaca aaaggtccga ctaggacttc accagtcgca gtctttttga
     3181 tgtcaacacc aggattttga acgtagcctt tgacgttccc cttggtatca gcgacggtga
     3241 taatagcacc tagagagcta gatcccaaca ccttaactgt aagtttggta tttccttttt
     3301 cattggctgc gagaatctgg ctggcgataa gagttcgacc aagcgctaca gttgagctag
     3361 cttgggtttg atgtttttct tgagcagtgc ggacggtttc agtgctatca aggacaaaag
     3421 cacgaaaggc tccgctttct gatatagttt taataatttt atccatagct actattttag
     3481 cataaaaatg cccaaagggg gagccgtgtg tttactgatt ttcaggataa tggaccagga
     3541 aatcagcatg aaaataaaaa gagaaacaga ttattttagc atttgtaaga tttatgctat
     3601 gcttaaggta gaaaatgaaa ggggtaacaa atgtatttag gagatttgat ggagaaagcc
     3661 gagtgtggtc aattttcaat cctttccttt ctattacaag agtctcagac gaccgtcaag
     3721 gctgtaatgg aagaaacagg attttcaaaa gcaaccctaa ccaaatatgt caccctgctc
     3781 aatgacaagg ctttggatag tggcttagag ctgactattc actcagaaga tgaaaatctg
     3841 cgtctgtcta tcggtgcagc taccaagggg agagatattc ggagcttgtt tttggatagt
     3901 gctgttaaat accagatttt ggtttatctt ctctaccacc aacagttttt agcccatcag
     3961 ctggctcaag aattggtgat tagcgaggct acgcttggtc gtcacttggc tggtttaaat
     4021 cagattttgt cagaatttga tttatccatc caaaatggac gctggagagg tccagagcat
     4081 cagattcgct atttctattt ctgtcttttc cgaaaggtct ggtcgagtca ggaatgggaa
     4141 ggtcacatgc agaaaccaga gagaaaacag gagattgcca atttagagga aatctgcggt
     4201 gcaagtttgt ctgcggggca gaaattggac ttggttctct gggctcacat cagtcaacaa
     4261 cgtcttcggg tcaatgcttg tcagtttcaa gtcatagaag agaaaatgcg agggtatttt
     4321 gacaatatct tttatcttcg tttgctgaga aaggttccgt ccttttttgc tgggcaacat
     4381 attccactag gagttgagga tggtgagatg atgatattct tctcttttct cctatctcat
     4441 cgcattcttc ctcttcatac tatggagtat attcttggtt ttggagggca gttggcagat
     4501 ttactgacgc aattgattca agaaatgaag aaggaggaac tattggggga ttatacagag
     4561 gaccatgtca cctatgaact cagtcagctt tgtgctcaag tctatctcta taagggctat
     4621 attttacagg atcgctacaa gtaccagtta gagaatcgtc atccatattt actgatggaa
     4681 catgatttta aagagacagc agaggagatt tttcatgctc tacctgcttt tcaacagggg
     4741 acagatttag ataagaagat tctctgggaa tggctccagt taatcgaata tatggctgaa
     4801 aacggtggcc agcatatgcg gattggtctg gatttgacat ctggttttct tgtcttttca
     4861 aggatggcag ccattttgaa acggtatttg gaatacaatc gttttattac cattgaagct
     4921 tatgacccta gtcggcatta tgatttgctg gttaccaata acccgattca taagaaggaa
     4981 cagacaccag tctattattt aaaaaatgac ttggatatgg aggatttggc agggattcgt
     5041 cagttattat tcacttaaaa ggcttggtta atccaggtct tttttgtgaa attcacacaa
     5101 tctcctcaca tttttttaaa aattaaaaaa agttgataaa caagaaagcg ctttattttg
     5161 tatactagta agtgtaaaga ggaaacacct caagatcttt atcaggagga cagtatatgt
     5221 cacaagaaaa atacatcatg gccattgacc agggaactac aagttctcgt gccatcattt
     5281 tcaacaaaaa aggggaaaag gttagctcga gtcaaaaaga gtttacccag attttccctc
     5341 aggcaggttg ggttgagcac aatgccaatg aaatttggaa ctctgttcag tcagttattg
     5401 cgggtgcttt catcgaaagt ggtgtcaagc caaatcaaat cgaggcaatc gggattacca
     5461 accaacgtga aacaacggtt gtctgggata agaaaacagg acttcctatc tacaatgcta
     5521 tcgtttggca gtcacgccag acagcacctt tggctgagca actaaaaagc caaggttatg
     5581 tggaaaaatt ccatgaaaag actggtttga ttattgatgc ttacttctct gctaccaagg
     5641 ttcgttggat tttggatcat gtagaaggcg ctcaagagcg agcagaaaaa ggggaattgc
     5701 tctttggtac tatcgatact tggttggttt ggaaattgac tgacggtgcg gctcacgtga
     5761 ctgactactc aaatgcagct cgtaccatgc tttataacat taaagaactc aaatgggatg
     5821 atgaaatttt ggaaatcctt aacattccga aggctatact tccagaagtt cgttctaact
     5881 ccgaaatcta cggcaagaca gctccattcc atttctacgg tggagaggtg ccaatctcag
     5941 gtatggctgg ggaccaacaa gcagccctct ttggacagtt ggcttttgag ccaggtatgg
     6001 ttaagaatac ttatggaaca ggctctttca tcatcatgaa tactggggaa gagatgcagt
     6061 tgtctgaaaa caacctcttg acaaccattg gttacggaat caacggtaag gtttattatg
     6121 ccttggaagg ttctatcttc atcgcaggaa gtgctattca gtggcttcgt gacggtcttc
     6181 gcatggttga aaattcacca gaatctgaaa aatacgctcg tgattctcac aacaacgatg
     6241 aagtttatgt cgttccagcc tttacaggtc taggcgctcc atactggaac caaaatgctc
     6301 gtggttccgt ctttggtttg actcgtggaa caagcaaaga agactttatc aaggcgactt
     6361 tgcaatctat tgcttatcaa gtgcgtgaca tcatcgacac catgcaagtg gatactcaga
     6421 ccgccattca agtattgaag gtggatggtg gtgcagccat gaacaacttc ctcatgcagt
     6481 tccaggcgga tattttaggc attgatattg cacgtgctaa aaacttggaa acaacagctc
     6541 taggagcggc cttcctagca ggtttatcag tagggtactg gaaagacttg gacgagttga
     6601 aactcttgaa cgagacagga gaactctttg agccatctat gaatgaatct cgcaaggaac
     6661 aactctacaa gggctggaag aaggctgtga aagcaactca agtctttgcg gaagtagacg
     6721 actaatactg gcagaataaa gcgatttatt tagaaagtgt gtaaatatgg aattttcaaa
     6781 gaaaacacgt gaattgtcaa ttaaaaaaat gcaggaacgc accctggacc tcttgattat
     6841 cggtggagga atcacagggg ctggtgtagc cttgcaggcg gcagctagcg gtcttgagac
     6901 tggtttgatt gaaatgcaag attttgcaga aggaacatct agtcgttcaa caaaattggt
     6961 tcacggagga cttcgttacc ttaaacaatt cgacgtagaa gtggtctcag atacggtttc
     7021 tgaacgtgca gtggttcaac aaatcgctcc acacattcca aaatcagacc caatgctctt
     7081 accagtttac gatgaagatg gagcgacctt tagcctcttc cgtctcaaag tagccatgga
     7141 cttgtacgac cttttagcag gtgtgagcaa cacgtcagct gcgaacaagg ttttgagcaa
     7201 ggatcaagtc ttggaacgcc agccaaactt gaagaaggaa ggcttggtag gaggtggagt
     7261 gtatcttgac ttccgtaaca acgatgcgcg tctcgtgatt gaaaacatca aacgtgccaa
     7321 ccaagacggt gccctcattg ccaaccacgt gaaggcagaa ggcttcctct ttgacgaaag
     7381 tggcaagatt acaggtgttg tagctcgtga tctcttgaca gaccaagtat ttgaaatcaa
     7441 ggcccgtctg gttattaata caacaggtcc ttggagtgat aaagtacgta atttgtctaa
     7501 taagggaacg caattctcac aaatgcgccc aactaaggga gttcacttgg tagtggattc
     7561 aagcaaaatc aaggtttcac agccagttta cttcgacaca ggtttgggtg acggtcgtat
     7621 ggtctttgtt ctcccacgtg aaaacaagac ttactttggt acaactgata cagactacac
     7681 aggtgatttg gagcatccaa aagtaactca agaagatgta gattatctac ttggcattgt
     7741 caacaaccgc tttccagaat ccaacatcac cattgatgat atcgaaagca gctgggcagg
     7801 tcttcgtcca ttgattgcag ggaacagtgc ctctgactat aatggtggaa ataacggtac
     7861 catcagtgat gaaagctttg acaacttgat tgcgactgtt gaatcttatc tctccaaaga
     7921 aaaaacacgt gaagatgttg agtctgctgt cagcaagctt gaaagtagca catctgagaa
     7981 atatttggat ccatctgcag tttctcgtgg gtctagcttg gaccgtgatg acaatggtct
     8041 tttgactctt gctggcggta aaatcacaga ctaccgtaag atggctgaag gagctatgga
     8101 gcgcgtggtt gacatcctca aagcagaatt tgaccgtagc tttaaattga tcaattctaa
     8161 aacttaccct gtttcaggtg gagaattgaa cccagcaaat gtggattcag aaatcgaagc
     8221 ctttgcgcaa cttggagtat cacgtggttt ggatagcaag gaagctcact atctggcaaa
     8281 tctttacggt tcaaatgcac cgaaagtctt tgcacttgct cacagcttgg aacaagcgcc
     8341 aggactcagc ttggcagata ctttgtccct tcactatgca atgcgcaacg agttggctct
     8401 tagcccagtt gacttccttc ttcgtcgtac caaccatatg ctctttatgc gtgatagctt
     8461 ggatagcatc gttgagccag ttttggatga aatgggacga ttctatgact ggacagaaga
     8521 agaaaaagca acttaccgtg ctgatgtcga agcagctctc gctaacaacg atttagcaga
     8581 attaaaaaat taagaaaaaa taaaagaggt ggagggcagc attccttgtc gctcgtccct
     8641 tctttttaat ggagacagaa agatgatgaa tgaattattt ggagaatttc tagggacttt
     8701 aatcctgatt cttctaggaa atggtgttgt tgcaggtgtg gttcttccta aaaccaagag
     8761 caatagctca ggttggattg tgattactat gggttggggg attgcagttg cggttgcagt
     8821 atttgtatct ggcaagctca gtccagctca tttaaatcca gctgtgacaa ttggtgtagc
     8881 tttaaaaggt gacttgcctt gggcttccgt tttgccttat atcttagccc agttcgcagg
     8941 ggctatgctg ggtcagattt tggtttggtt gcaattcaaa cctcactatg aggcagaaga
     9001 aaatgcaggc aatatcctgg caaccttcag tactggacca gccatcaagg atactgtatc
     9061 aaacttgatt agcgaaatcc ttggaacctt tgttttggtg ttgacaatct ttgctttggg
     9121 tctttacgat tttcaggcag gtatcggaac ctttgcagtg ggaactttga ttgtcggtat
     9181 cggtctatca ctaggtggga caacaggtta tgccttgaac ccagctcgtg accttggacc
     9241 tcgtatcatg cacagcatct tgccaattcc aaacaaggga gacggagact ggtcttacgc
     9301 ttggattcct gttgtaggcc ctgttatcgg agcagccttg gcagtgcttg tattctcact
     9361 tttctagttt atactcttcg aaaatcaaat tcaaaccacg tcagcgtcgc cttaccgtac
     9421 tcaagtacag cttgcggcta gcttcctagt ttgctctttg attttcattg agtattagaa
     9481 aacaattatg ttgatagagc ttgggcaaga gcccaatttc agcaaaaaat gaagtaaatc
     9541 ttctcataat aaaacgcatc atatcaagca cgaaaattcc acgaggtcaa ctacagtcag
     9601 aaagctgaac aacaagccaa aacgcccaaa aaaggcggca aaaagcaagc acctgcaagc
     9661 aacgtgccga aatggtcaaa tcctgattat gtcaacgaat tagacccaaa aatcgttgat
     9721 atgctagtag aatttcacaa gtcacaaggc actttggaaa ctcccgaggc gcaagcagaa
     9781 atcgcccaaa aacgtgaaga aatcgagcaa aggagagctg agcttgaggg taaaaaacaa
     9841 gagcttttga accgcttgaa caaatagagt ttcgcaagta ttatgcttac aaattacttg
     9901 agcaattaac taaaatataa accctgcctt tatatctagg cagggtttat attttagaaa
     9961 ttcacgtagg ttgttacggt ttttacatac ccagtatagt ttgagtttct atagtattca
    10021 gtgataaact tccattttct ttgagcaaca tggatataag tacttgttat gtagtatgga
    10081 tatgggcttt gtgaatccaa gtaagactga taagcttgta tactaaaata tgctccacca
    10141 attattgcac cccatggacc ccccaataaa gcacctatcc taccaatcat ataactgatt
    10201 ccagcaccag tcatgaagtt agcgaatgtg ttagcttgtt tattcccatg tattgtgttg
    10261 acgtaattcc aaacattagg atcgtatgat ctaaaagata tatttaggtc gatttcattc
    10321 ttttgataag ccatataaaa tgccccattg atatagacgc cgtcagcacg tcgttcaata
    10381 gtgtctacac ttccatctgg attgacaacc tcaagaactt catcgcttaa aatatttact
    10441 tgcgtatctc cgaaccgcac tgatgagcca ttctcaaact gagcctcacc agatacaact
    10501 ttagagtttg ccgataagct atcatcagca aaaacaaaca agcgacgggg aaatgctaga
    10561 catacagaaa acagacataa ctagcaaaca catgcattta aacatcttag acataacgga
    10621 aactcctttg tatttttgat ttttttcaac ttttattata caataaaacc aaataaaaag
    10681 aaagcggtaa caatatgctt aatgcgaaaa ttttttatat atttttatgt ttgatcgtta
    10741 tcgaaactac aggcttgttg ttgttgaaaa gaggtctcga aatgggttat ttagacacag
    10801 aagctattat cctcgcagtt ttttcatttg ctttttacaa cctatgttca ttcgcttggg
    10861 tctgctctac aataaaaaac aataaaaaat aaatagacgt attttcaaaa aaaaaaaaaa
    10921 atgcatattt atcttagcaa aacgacgatt taaatcgtcg tttttttgt
//
LOCUS       DAVHIZ010000056        10741 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.058, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000056 DAVHIZ010000000
VERSION     DAVHIZ010000056.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10741)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10741)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10741
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.058"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(104..1528)
                     /locus_tag="VVO18_001700"
     CDS             complement(104..1528)
                     /locus_tag="VVO18_001700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-dependent glyceraldehyde-3-phosphate
                     dehydrogenase"
                     /protein_id="HEU5586811.1"
                     /translation="MTRYQNLVNGKWKSSEQEITIYSPINQEELGTVPAMTQTEADEA
                     MQAARAALPAWRALSAIERAAYLHKTAAILERDKEKIGTILAKEVAKGIKAAIGEVVR
                     TADLIRYAAEEGLRITGQAMEGGGFEAASKNKLAVVRREPVGIVLAIAPFNYPVNLSA
                     SKIAPALIAGNVVMFKPPTQGSISGLLLAKAFEEAGIPAGVFNTITGRGSEIGDYIIE
                     HKEVNFINFTGSTPIGERIGRLAGMRPIMLELGGKDAALVLEDADLEHAAKQIVAGAF
                     SYSGQRCTAIKRVIVLESVADKLATLLQEEVSKLTVGDPFDNADITPVIDNASADFIW
                     GLIEDAQEKEAQALTPIKREGNLLWPVLFDQVTKDMKVAWEEPFGPVLPIIRVASVEE
                     AIAFANESEFGLQSSVFTNDFKKAFEIAEKLEVGTVHINNKTQRGPDNFPFLGVKGSG
                     AGVQGIKYSIEAMTNVKSIVFDVK"
     gene            complement(2072..4351)
                     /gene="pulA"
                     /locus_tag="VVO18_001701"
     CDS             complement(2072..4351)
                     /gene="pulA"
                     /locus_tag="VVO18_001701"
                     /EC_number="3.2.1.41"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000283081.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I pullulanase"
                     /protein_id="HEU5586812.1"
                     /translation="MYNYPMRIHYHRKNGEYDTCSFVKSQDQRIDLLTYKEDYFGALF
                     SFEHPSSHVIESLNFVVHTGQTSKEYSIRFNHYPLLTEVWILEGDDRIYYSENPAIAS
                     PFYKNQNPFAFDKAINSASFDHHWGYQGELGCRVEDNQAHFSLWSPTATEVQVVVYES
                     AANDAPVWKTFEMKRGNSYSYNHKDNTIGVWSLDVEEDLVGKTYQYQVQFPHHQTLTR
                     DPYTIATSPDGKRSAILSHVEKQVENFEVKHGSEATWRLENPCKAVICEMHIRDLTKS
                     PTSGVDEHLRGTFLGAAQAGTVNQYGQSTAFDYIKKLGYNYVQLQPIADRHKEYDEDG
                     NVTYNWGYDPQNYNAPETSFSTNPDDPAQVIRDLKVMVQAYHDAGIGVIMDVVYNHTF
                     SVVDAPFQTTVPDYYYRMNPDGTFQNGTGVGNETASEHEMFRKYMIDSLLYWVQEYNI
                     DGFRFDLMGIHDVKTMQMIRQSLDEIDSNIILYGEGWDMGTGLAPYDKAKKDNAYQMP
                     NIGFFNDNQRDAVKGGEVYGAIKSGFVSGAATEPILAKAILGSRELGSYTHPNQVLNY
                     VEAHDNYNLHDLLATLHPDQSSEQIMRKVETATAMNLLMQGMAFMEIGQEFGRTKLVA
                     TGENGELTHDDRERAMNSYNAPDSVNQVNWNLINERQDSIEFIRQVIRLKTKTGAFSY
                     SSYDEIYHHVFVHSAIEHSGYLIYEVHGKEHFLVVVNAKSDPYQFENAGNLAMLVTNS
                     RSKEDNVLNDISLAVLSVL"
     gene            complement(4463..6421)
                     /gene="ligA"
                     /locus_tag="VVO18_001702"
     CDS             complement(4463..6421)
                     /gene="ligA"
                     /locus_tag="VVO18_001702"
                     /EC_number="6.5.1.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001042597.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="HEU5586813.1"
                     /translation="MNKRMNELVALLNRYATEYYTSDNPSVSDSEYDRLYRELVELET
                     AYPEQVLADSPTHRVGGKVLDGFEKYSHQYPLYSLQDAFSREELDAFDARVRKEVAHP
                     TYICELKIDGLSISLTYEKGILVAGVTRGDGSIGENITENLKRVKDIPLTLPEELDIT
                     VRGECYMPRASFDQVNQVRQENGEPEFANPRNAAAGTLRQLDTAVVAKRNLATFLYQE
                     ASPSTRDSQEKGLKYLEQLGFVVNPKRILAENIDEIWNFIQEVGQERENLPYDIDGVV
                     IKVNDLASQEELGFTVKAPKWAVAYKFPAEEKEAQLLSVDWTVGRTGVVTPTANLTPV
                     QLAGTTVSRATLHNVDYIAEKDIRKDDTVIVYKAGDIIPAVLRVVESKRVSEEKLDIP
                     TNCPSCNSDLLHFEDEVALRCINPRCPAQIMEGLIHFASRDAMNITGLGPSIVEKLFA
                     ANLVKDVADIYRLQEEDFLLLEGVKEKSAAKLYQAIQASKENSAEKLLFGLGIRHVGS
                     KASQLLLQYFHSIENLYQADSEEVASIESLGGVIAKSLQTYFATEGSEILLRELKETG
                     VNLDYKGQTVVADAALSGLTVVLTGKLERLKRSEAKSKLESLGAKVTGSVSKKTDLVV
                     VGADAGSKLQKAQELGIQVRDEAWLESL"
     gene            complement(6514..7692)
                     /locus_tag="VVO18_001703"
     CDS             complement(6514..7692)
                     /locus_tag="VVO18_001703"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001083019.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /protein_id="HEU5586814.1"
                     /translation="MNRYAVQLISRGAINKMGNMLYDYGNSVWLASMGTIGQTVLGMY
                     QISELVTSILVNPFGGVISDRFSRRKILMTADLVCGILCLAISFIRNDSWMIGALIVA
                     NIVQAIAFAFSRTANKAIITEVVEKDEIVIYNSRLELVLQVVGVSSPVLSFLVLQFAS
                     LHMTLLLDSLTFFIAFVLVAFLPKEEAKVQEKKAFTGRDIFVDIKDGLHYIWHQQEIF
                     FLLLVASSVNFFFAAFEFLLPFSNQLYGSEGAYASILTMGAIGSIIGALLASKIKANI
                     YNLLILLALTGVGVFMMGLPLPTFLSFSGNLVCELFMTIFNIHFFTQVQTKVESEFLG
                     RVLSTIFTLAILFMPIAKGFMTVLPSVHLSSFLIIGSGVIILSCISFIYVRTHFEKLI
                     "
     gene            complement(7772..8635)
                     /locus_tag="VVO18_001704"
     CDS             complement(7772..8635)
                     /locus_tag="VVO18_001704"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012291596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="HEU5586815.1"
                     /translation="MEHLGKVFREFRTSGNYSLKEAAGESCSTSQLSRFELGESDLAV
                     SRFFEILDNIHVTIENFMDKARNFHNHEHVSMMAQIIPLYYSNDIAGFQKLQREQLEK
                     SKSSTTPLYFELNWILLQGLICQRDATYDMKQDDLDKVADYLFKTEEWTMYELILFGN
                     LYSFYDVDYVTRIGREVMEREEFYQEISRHKRLVLILALNCYQHCLDHSSFYNANYFE
                     AYTEKIIDKGIKLYERNVFHYLKGFALYQKGQCKEGCKQMQEAMHIFDVLGLPEQVAY
                     YQEHYEKFVKS"
     gene            complement(8638..10539)
                     /locus_tag="VVO18_001705"
     CDS             complement(8638..10539)
                     /locus_tag="VVO18_001705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000584877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="HEU5586816.1"
                     /translation="MIILQANKIERSFAGEVLFDNINLQVDERDRIALVGKNGAGKST
                     LLKILVGEEEPTSGEINKKKDISLSYLAQDSRFESENTIYDEMLHVFNNLRRTERQLR
                     QMELEMGEKSGEDLDKLMSDYDRLSENFRQAGGFTYEADIRAILNGFKFDESMWQMKI
                     AELSGGQNTRLALAKMLLEKPNLLVLDEPTNHLDIETIAWLENYLVNYSGALLIVSHD
                     RYFLDKVATITLDLTKHSLDRYVGNYSRFVELKEQKLATEAKNYEKQQKEIAALEDFV
                     NRNLVRASTTKRAQSRRKQLEKMERLDKPEAGKKAANMTFQSEKTSGNVVLTVENTAI
                     GYDGEVLSQPINLDLRKMNAVAIVGPNGIGKSTFIKSIVDQIPFIKGEKRFGANVEVG
                     YYDQTQSKLTPSNTVLDELWNDFKLTPEVEIRNRLGAFLFSGDDVKKSVGMLSGGEKA
                     RLLLAKLSMENNNFLILDEPTNHLDIDSKEVLENALIDFDGTLLFVSHDRYFINRVAT
                     HVLELSENGSTLYLGDYDYYVEKKATAEMSQTEEASTSNQAKEASPVNDYQAQKESQK
                     EVRKLMRQIESLEAEIEELESQSQAISEQMLETNDADKLMELQAELDKISHRQEEAML
                     EWEELSDQV"
BASE COUNT         3224 a         2369 c         1913 g         3235 t
ORIGIN      
        1 gtttcaatct attataatac caaaaagttc gtattttttc tataattatt attattttat
       61 agcaaaaaat aaaaccagga aaacaatttc ctgattttac acgttatttc acatcaaaaa
      121 caatggattt gacatttgtc atcgcttcaa tgctatattt aattccttgc actccagctc
      181 cagaaccttt gacaccaagg aatgggaaat tatctggacc acgctgggtt ttattattaa
      241 tgtggactgt acctacttca agtttttcag caatttcaaa ggcttttttg aaatcatttg
      301 taaaaactga tgattgaagg ccgaattcag attcgttggc aaaggcaata gcctcctcta
      361 cactagccac acgaatgatt ggtaaaacag gaccaaatgg ctcttcccat gccactttca
      421 tatcttttgt aacttggtca aaaagcactg gccagaggag attgccctca cgtttgattg
      481 gtgtaagagc ctgagcctct ttttcttgtg catcctcaat caagccccaa atgaagtcgg
      541 ctgaagcatt gtcaataaca ggtgtaatat cagcattgtc aaatggatca ccaactgtta
      601 atttagaaac ttcttcctga agcaaagtag ctaatttatc tgctacactt tcgagaacaa
      661 tgacacgttt aatggccgtg caacgttgtc ctgagtagct aaaggctccc gcaacaattt
      721 gcttggcagc atgttccaaa tctgcatctt ctagtacaag agctgcatct ttcccaccaa
      781 gttccaacat gataggacgc ataccagcta aacgaccaat acgttctcca ataggagttg
      841 aacctgtaaa gttgatgaag ttgacttctt tgtgctcaat gatataatcc ccaatttctg
      901 aaccacgacc tgtaatggtg ttgaaaacac ctgccggaat ccctgcttct tcaaatgctt
      961 tagccaacaa gagtccagaa atggaacctt gtgttggtgg cttaaacatg accacattcc
     1021 ctgcaatcaa ggcaggtgca attttagaag cagataaatt aactggataa ttaaaaggag
     1081 caatcgctag cacgatacca actggttcac gacggacaac agccagtttg tttttacttg
     1141 ctgcctcaaa accaccacct tccattgctt gtccagtgat acggagacct tcctcagcag
     1201 cataacgaat caagtctgct gtacgcacta cttctccaat tgctgcttta atcccttttg
     1261 ctacttcttt ggcaaggata gtaccaattt tttccttatc gcgttctaaa atagctgctg
     1321 ttttatgcaa ataagccgca cgttcaattg ctgataaagc tcgccatgct ggcagggctg
     1381 cacgcgcagc ttgcatagcc tcatcagctt cagtctgagt catggctgga actgtaccca
     1441 attcttcttg attgattggt gagtaaatcg taatttcttg ttcagatgat ttccattttc
     1501 catttactaa attctgatat cttgtcaaat tcttgtcctc ctgaaaatga ttaagatata
     1561 ttttaccaaa ttttcagaaa atcacaaccc tttttgcaaa atttttgaga ttattttcac
     1621 aaacttgatt tttcaaagta tactcaataa aaataaaaaa aatccactac gtcaaggcga
     1681 ggctaatgtg gtttgaagaa attttcgaag agcgtgaatg agtatcatct atagtaaaat
     1741 aaaaaactga acaatttggt tggggacagc caaaccaatt tctcacaatg tttcagaaac
     1801 aagggtgtgc tactccaatt tcggcctact ataactgtca tagattgctg aaacaaagtc
     1861 taggtaaaag tcttcataat aaaaagacct cctatcaaat gttcaaaaac tttgatagga
     1921 ggtcttgttt cgtgaaaata tttatcaaat tttctataca agtgagctgt tagccaggtt
     1981 ctttctattc tttcaatttc aatgaatgga ttttttacca atactcataa ctgggaattt
     2041 ttctgtctaa aaatagcgag atagatggta tttataaaac actcaagaca gctagactaa
     2101 tatcatttaa aacattatct tcttttgagc gactgttggt taccaacata gctaaatttc
     2161 ctgcattttc aaattgatag gggtctgatt tagcattcac aaccaccaag aagtgttctt
     2221 tgccgtgaac ttcatagata aggtagccgc tatgttcaat cgcagaatgc acaaagacat
     2281 gatggtaaat ttcatcatag ctagagtaag aaaaggcacc agtttttgtc ttcaatcgga
     2341 tgacttgacg gataaactca atactgtctt gacgctcatt aatcaagttc cagttcactt
     2401 ggttcacact gtcaggagca ttatagctat tcatcgcacg ctctctatca tcatgggtta
     2461 actcaccatt ttcaccagtc gcaaccagtt tggtacgacc aaattcttga ccgatttcca
     2521 taaaggccat cccctgcatg agcagattca tggctgtggc agtttcgacc ttgcgcatga
     2581 tttgctctga actttggtct ggatgaaggg ttgccaataa atcgtgaaga ttgtaattgt
     2641 catgggcttc tacatagtta agcacctgat ttggatgtgt atagcttcct aattcacgac
     2701 ttcctaggat tgctttagct agaattggct ctgtcgcagc accactgaca aaacctgact
     2761 tgatagcacc ataaacttct ccccctttga cagcatcgcg ctgattgtca ttaaagaaac
     2821 caatatttgg catctggtag gcattgtcct tcttggcctt atcataaggg gcaagacctg
     2881 ttcccatatc ccatccttct ccatagagga taatgttgga gtcgatttca tccaagcttt
     2941 gacgaatcat ctgcatggtc ttgacatcat gaatccccat caagtcaaaa cggaagccgt
     3001 caatattata ttcctgcacc cagtatagaa gagaatcaat catatacttg cgaaacattt
     3061 cgtgttcact ggctgtttca tttccaacac ccgttccatt ctggaaggta ccatctggat
     3121 tcatacgata atagtaatca gggactgttg tttggaatgg tgcatcaaca actgagaagg
     3181 tatggttata gactacatcc ataatgactc caatacccgc atcgtgataa gcttgaacca
     3241 tcaccttcaa atcacgaatg acctgagctg gatcatctgg attagttgaa aaactagttt
     3301 ctggcgcgtt atagttttgt ggatcataac cccagttgta ggttacattt ccatcctcat
     3361 cgtattcttt atgacggtct gcaattggtt gcaattgaac ataattgtag cccagcttct
     3421 tgatgtaatc aaaagcagtt gactggccgt attggttaac tgttccagcc tgagcagcac
     3481 ccaagaaagt tcctcgaaga tgttcatcta cacccgatgt aggtgattta gtcaaatcac
     3541 gaatgtgcat ttcacagata actgccttac atggattttc caagcgccaa gtagcctccg
     3601 aaccgtgctt aacctcgaag ttttcaactt gcttttctac atggctcaga atagctgaac
     3661 gtttgccatc agggctggtc gcgattgtat aaggatcacg tgtcagtgtt tggtgatgag
     3721 ggaattggac ttgatactga taagtcttac ctaccaaatc ttcttcaaca tccaaactcc
     3781 agacaccgat tgtattgtcc ttatgattat aagagtagct attgcctctt ttcatctcaa
     3841 aagtcttcca aacgggtgca tcattagcag ctgattcata aacgacaact tgcacttctg
     3901 tcgctgtagg tgaccagaga gaaaaatgag cctgattgtc ctctacacgg caacccaatt
     3961 ctccttggta accccaatga tgatcaaaac tagcactgtt aatggcctta tcaaaggcaa
     4021 aaggattttg atttttatag aaaggactgg caatagcagg attttcagag taataaatcc
     4081 tatcatcgcc ttccaaaatc cagacctctg ttaatagggg atagtgatta aaacggatag
     4141 aatattcttt actagtttga cctgtatgaa ccacaaaatt caagctttct ataacatgtg
     4201 aacttgggtg ttcaaagcta aataaagctc caaaataatc ttctttgtag gttagcaaat
     4261 caattcgttg atcctgactt tttacaaagg agcaagtgtc atattctcca ttcttacgat
     4321 ggtaatgaat gcgcataggg tagttataca ttttttattt ttccttttta ctttgtttct
     4381 atttcactaa taaatttttg tcaatctcgt ctcaattaac agacatagtc atattctcta
     4441 aactctgttt ttaaacgatc cattacaaac tttctagcca tgcctcatct ctgacctgga
     4501 taccaagttc ttgtgctttt tgcagtttac ttccagcgtc tgcacctacc acgacgaggt
     4561 cggtcttttt agaaacacta cctgtcactt tggcacccag actttcgagt ttacttttag
     4621 cttctgagcg cttgagtcgt tccaattttc ctgtcaatac cacggtcaaa cctgacaagg
     4681 ccgcatccgc tactaccgtc tgtcctttat agtccagatt gaccccagtt tctttcaatt
     4741 ctctgagcag aatttcagag ccttctgtcg caaaataagt ctgaagactt ttggcaatca
     4801 cgccacctag actttcaata ctagccactt cctctgaatc tgcctgatac agattttcaa
     4861 ttgaatggaa atattgaagt aaaagctgac tagccttgct tccgacatga cgaattccca
     4921 aaccaaataa gagcttctcg gcagaatttt cctttgatgc ttggatagcc tgatacagtt
     4981 tagcagcgga cttttcctta accccctcta aaaggaggaa atcctcttct tgcaaacgat
     5041 aaatatccgc cacatccttg actaaattag cagcaaaaag cttctcaaca atagatggac
     5101 caaggcctgt aatattcata gcatcacgag aagcaaagtg aatcaagcct tccatgattt
     5161 gagcagggca acgcggattg atacaacgta gggccacttc atcttcaaag tgcaacaagt
     5221 cagagttaca acttggacag tttgtaggga tatctagttt ttcttcagaa acccgtttgg
     5281 actctaccac acgtaaaacg gcagggatga tgtcaccagc cttatataca atgaccgtat
     5341 cgtcttttcg gatatctttt tcagcaatat aatctacatt gtgcagggtc gcacggctaa
     5401 cagtcgtacc ggcaagttgt actggtgtta gattagcagt tggagttaca acaccggtac
     5461 ggccaactgt ccagtcaact gataagagtt gagcttcttt ttcttcagca gggaacttgt
     5521 aggctactgc ccactttgga gccttaacgg taaaaccaag ttcttcttga cttgctaggt
     5581 cgttgacctt gattaccact ccatcaatat cgtaaggcag attttcccgt tcctgtccta
     5641 cttcttggat aaaattccag atttcatcta tgttttcagc caagattcgc ttaggattga
     5701 ccacaaaacc tagttgttct aggtacttca aacccttttc ttggctatca cgagttgaag
     5761 ggctggcttc ttgatagaga aacgttgcaa gattacgctt ggcaactact gctgtatcca
     5821 actgacgcag agttcctgct gccgcattac gaggattagc aaattcaggc tctccatttt
     5881 cttggcgcac ttggttaact tggtcaaagg aagcgcgtgg catgtaacat tccccacgaa
     5941 ctgtgatatc tagttcttct ggcaaagtca aagggatgtc cttaacacgc ttgaggtttt
     6001 ctgtgatatt ttcaccaatt gaaccatctc cacgtgttac cccagcaacc aaaatcccct
     6061 tttcataagt cagcgagata gataagccat cgattttcag ctcacaaata taggtcggat
     6121 gagccacttc cttacgaaca cgcgcatcaa aagcatctag ctcctcacgt gaaaaagcat
     6181 cctgcaaact ataaagagga tactgatgac tgtatttttc aaaaccatct aaaaccttgc
     6241 caccaacacg atgagtcgga ctgtctgcta gcacttgctc tggataagca gtttctaact
     6301 cgaccaactc acggtaaagg cggtcatact cactgtctga aaccgaggga ttatcgctgg
     6361 tatagtactc agtcgcatag cgattgagca aagcgactaa ctcattcatt cttttattca
     6421 taagaccatt ttaccataaa acaagccctc ctcacaaacg agaaggacgg aaaaaacact
     6481 tagtttgaaa ttatttttga aactcaagca accttatatc aatttttcaa aatgagttcg
     6541 aacataaata aacgatatac aagacaagat gataacacca cttccaatta tcaggaaaga
     6601 agagagatgt acacttggca agactgtcat aaatcctttt gcaataggca taaatagaat
     6661 agctaaggta aaaattgtac tcagtactct cccaagaaat tcgctctcaa ccttggtttg
     6721 tacttgagta aaaaagtgaa tattaaaaat cgtcataaac aattcacaaa ctaaatttcc
     6781 agaaaaggaa agaaaagttg gaagtggtaa tcccatcata aaaactccga cacctgtcaa
     6841 agccagtaaa atcaaaagat tataaatatt agctttaatt ttactagcta gaagagcccc
     6901 aatgatggaa ccaatagccc ccatagttaa aatacttgca taggctcctt ctgacccgta
     6961 aagctgattc gaaaagggaa gtagaaattc aaaagctgca aaaaagaaat taacgctgga
     7021 agctaccagc aaaaggaaga aaatttcttg ctgatgccag atatagtgta acccatcctt
     7081 gatatctaca aaaatatctc tcccagtaaa agcctttttc tcttgaactt ttgcttcctc
     7141 ttttggaagg aaagccacta gaacaaaagc aatgaaaaaa gtcagcgagt ctagcagtag
     7201 cgtcatatgg agacttgcaa actgtaaaac aaggaaggaa agaacaggag agctaacacc
     7261 tacaacctgc aaaaccagct ctaggcgaga attatagatc acaatctcat ctttctccac
     7321 cacttcagtt atgatagctt tattggctgt gcgagaaaag gcaaaagcaa tagcctgcac
     7381 aatgttagca acaatcaaag cgccaatcat ccagctatca ttccttatga aagaaatagc
     7441 cagacaaaga atcccacaaa caagatctgc cgtcattaaa atcttacgac gagaaaaacg
     7501 gtctgaaata actccgccaa agggattgac gagaatagat gtgacgagct cagaaatctg
     7561 atacattcct aaaactgtct gtcctatagt ccccatggaa gccaaccaga cactatttcc
     7621 ataatcatag agcatatttc ccattttatt gatagcccca cggctaatca actgcactgc
     7681 atagcgattc atattaaagc tcctctcaaa ttttgaaact attgtatcaa aaccgaaagg
     7741 agctttttat tttttccctt atttgggaaa attaactttt gacaaatttt tcgtagtgtt
     7801 cctgataata ggctacttgc tctggaagac ctaacacatc aaaaatatgc atggcctctt
     7861 gcatctgctt acagccttct ttacactgtc ctttttgata taaggcaaaa ccttttaaat
     7921 aatggaaaac attacgctca taaagcttaa tacctttgtc aataatcttc tctgtataag
     7981 cctcaaaata gttggcatta taaaaagaag aatgatctaa acaatgctgg taacaattga
     8041 gggccaaaat caacactaat ctcttatggc gactaatctc ttggtaaaat tcctccctct
     8101 ccataacttc tctaccaatc cgagtgacat agtctacatc gtagaaacta tagaggttac
     8161 cgaaaagaat caactcatac atggtccatt cttctgtttt gaagagataa tctgctacct
     8221 tatccaaatc atcctgcttc atatcataag tcgcatctct ttgacaaatc agaccttgta
     8281 gcaaaatcca gttcagctca aaataaaggg gagtcgtcga actcttagac ttttcaagtt
     8341 gttctctttg aagcttttga aaacctgcaa tatcgtttga atagtaaagt gggataatct
     8401 gtgccatcat agacacatgt tcatgattat gaaaattcct tgccttatcc atgaaatttt
     8461 cgattgttac atgaatgtta tccaaaatct caaagaaacg ggagactgcc aggtcagact
     8521 ccccaagctc aaagcgagat aactgagagg tagagcagga ttcgcctgct gcttccttta
     8581 aagaataatt tccacttgtt cgaaattcac gaaatacttt tccaagatgt tccatcttta
     8641 cacctgatct gataattctt cccactcaag catagcttct tcctgacgat ggctgatttt
     8701 gtccagctca gcctgtaatt ccatgagttt gtcggcatcg tttgtttcca acatttgttc
     8761 agaaatggct tggctttgac tttctagctc ttcaatttca gcttctagac tttcgatttg
     8821 tcgcatgagt ttgcgaactt ctttttgact ttctttctgg gcctgatagt cattgactgg
     8881 acttgcttcc tttgcttgat tgctagttga agcttcctca gtctgactca tttctgctgt
     8941 tgctttcttc tcaacatagt agtcgtaatc tccaaggtag agagttgaac cattctcaga
     9001 caattccaaa acatgagttg ccacacgatt gataaagtaa cgatcatgac tgacaaaaag
     9061 caaggtacca tcaaagtcaa tcaaggcatt ttctagcact tccttactat caatatccaa
     9121 gtggttggtc ggctcatcca gaatcaaaaa gttattgttt tccatagaca atttagctaa
     9181 aagcaaacga gctttttcgc caccagatag catgccgact gattttttaa catcatctcc
     9241 tgagaaaagg aaggctccaa gacggttgcg gatttcaact tctggtgtca gtttgaaatc
     9301 attccagagt tcatccagca ccgtattact tggtgtcagc ttgctttggg tttggtcata
     9361 gtaacccacc tcaacattag cgccaaagcg cttttctccc ttgataaaag gaatctggtc
     9421 cacaatagac ttgataaagg ttgacttgcc gataccattt ggaccaacga tagcgacagc
     9481 attcatctta cgaagatcta ggttgatagg ttgtgacaag acttccccgt cataaccaat
     9541 agcagtattt tcaacagtca aaacaacatt gcccgacgtt ttttcagact ggaaggtcat
     9601 gttggctgct ttcttgccag cttcaggctt gtccaaacgc tccatttttt ctagttgttt
     9661 acggcgagat tgagcacgtt tagtcgttga agcacgaact agattgcgat tgacaaagtc
     9721 ttccagagca gcgatttcct tctgttgctt ttcatagttt tttgcctcag tagctagctt
     9781 ttgctccttc aattcgacaa aacgagagta attccccaca tagcgatcca aggaatgctt
     9841 ggtcaaatct agcgtaattg tcgcaacctt gtccaagaaa taacggtcgt ggctgacgat
     9901 aaggagggca ccgctatagt ttaccaagta attctctagc caggcgatgg tttcaatatc
     9961 caagtggtta gttggctcgt ccaagaccaa gagattgggc ttttcaagga gcattttggc
    10021 aagtgccaaa cgagtatttt gaccaccaga aagctcagca attttcatct gccacataga
    10081 ctcgtcaaac ttgaatccat tcaaaatcgc tcgaatatca gcttcatagg taaagccacc
    10141 tgcttggcga aaattctcag ataagcggtc ataatctgac atcagtttat ccaaatcctc
    10201 accagacttt tcacccatct ccagctccat ctgacgcagt tgtctctccg tccgacgcaa
    10261 attattaaag acatgaagca tttcatcgta gatggtattt tcagactcaa aacggctatc
    10321 ttgggctagg taagacagag aaatatcttt tttcttattg atttctccgc tagttggctc
    10381 ctcttctcca actaaaatct tcaaaagagt agacttacct gcaccatttt tcccaacaag
    10441 ggcaatccga tctcgttcat caacctgcag gttgatatta tcgaaaagaa cctctcctgc
    10501 aaaagaacgt tcaattttat tagcttgtaa aataatcata agagtagtat agcatgtttc
    10561 cctaaggcat tcaagataat cgtaagtctt ttagtacaac ttttataaca taaaataaac
    10621 taaattatgt atattttata ttagattctt cactatcttg ttggattttc taaccagcta
    10681 atcttgtttc aaatagttat cgcacaagcc tattatttaa ttcttttcat tatttacgta
    10741 c
//
LOCUS       DAVHIZ010000057        10490 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.059, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000057 DAVHIZ010000000
VERSION     DAVHIZ010000057.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 10490)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10490)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10490
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.059"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..533)
                     /locus_tag="VVO18_001706"
     CDS             complement(<1..533)
                     /locus_tag="VVO18_001706"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586817.1"
                     /translation="MKQFVQFYKKDFLSVLVYFILLLSCVLSSTVYLLRCRQYSIHPN
                     VLEWILVLLQDMTTGVYCFPFTYILFFFYLMNNYFNRLECRIRLKSIKHFTSFSFKLA
                     ALSTGIWTATLFLLIFLIAFSNGFSFSLEIKEVDFLREFYGISIANNASFFIGFFFSY
                     IAYYFFLSLLTISSFSW"
     gene            complement(533..1297)
                     /locus_tag="VVO18_001707"
     CDS             complement(533..1297)
                     /locus_tag="VVO18_001707"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000394067.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586818.1"
                     /translation="MEFFICNLVRVVQSPRFYMSLFLTLLCMSLGNFLAFNGIYKIEG
                     LSIFFAASSIRGFSPISLVAALICTLPYSSQIIEDAESHFLTAQLCRISKKKYLAIVG
                     STVIISSFLVFFLPYLLLLGINLLVTPYQEIYIGDYSGALKELFDSNQFLYSLVTTLW
                     YGVWGAVFSIFGLASALLVKKKIGAIFIPVAYMMVGGIFWAILGLSYLEPVTTLALGY
                     QKDISLSLVSGHLAFILFVSCLVVYGTFFLHSEDYV"
     gene            complement(1393..1796)
                     /locus_tag="VVO18_001708"
                     /pseudo
     CDS             complement(1393..1796)
                     /locus_tag="VVO18_001708"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000829085.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(1976..2608)
                     /locus_tag="VVO18_001709"
     CDS             complement(1976..2608)
                     /locus_tag="VVO18_001709"
                     /EC_number="2.4.2.10"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170913.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotate phosphoribosyltransferase"
                     /protein_id="HEU5586819.1"
                     /translation="MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLA
                     YPETRTLIENGFVEAIKEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDH
                     GAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
                     KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQENWQEG"
     gene            complement(2642..3343)
                     /gene="pyrF"
                     /locus_tag="VVO18_001710"
     CDS             complement(2642..3343)
                     /gene="pyrF"
                     /locus_tag="VVO18_001710"
                     /EC_number="4.1.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001206708.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="orotidine-5'-phosphate decarboxylase"
                     /protein_id="HEU5586820.1"
                     /translation="MREHRPIIALDFPSFEAVKEFLALFPAEESLYLKVGMELYYAAG
                     PEIVSYLKGLGHSVFLDLKLHDIPNTVKSAMKVLSQLGVDMTNVHAAGGVEMMKAARE
                     GLGSQAKLIAVTQLTSTSEAQMQEFQNIQTSLQESVIHYAKKTAEAGLDGVVCSAQEV
                     QVIKQATNPDFICLTPGIRPAGAAVGDQKRVMTPADAYQIGSDYIVVGRPITQAEDPV
                     AAYHTIKDEWTQDWN"
     gene            complement(3576..4796)
                     /gene="divIB"
                     /locus_tag="VVO18_001711"
     CDS             complement(3576..4796)
                     /gene="divIB"
                     /locus_tag="VVO18_001711"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031166.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell division protein DivIB"
                     /protein_id="HEU5586821.1"
                     /translation="MSKDKKNEDKETLEELKELSEWQKRNQEYLKKKAEEEAALAEEK
                     EKERQARMGEESEKSEDKQDQESETDQEDSESAKEESEEKVVSSEADKEKEEKEEPES
                     KEKEEQDKKLAKKATKEKPAKAKIPGIHILRAFTILFPSLLLLIVSAYLLSPYATMKD
                     IRVEGTVQTTADDIRQASGIQDSDYTINLLLDKAKYEKQIKSNYWVESAQLVYQFPTK
                     FTIKVKEYDIVAYYISGENHYPILSSGQLETSSVSLNSLPETYLSVLFNDSEQIKVFV
                     SELAQISPELKATIQKVELAPSKVTSDLIRLTMNDSDEVLVPLSEMSKKLPYYSKIKP
                     QLSEPSVVDMEAGIYSYTVADKLIMEAEEKAKQEAKEAEKKQEEEQKRLEEEQKKQEE
                     ESNRNQTTQRSSRR"
     gene            complement(4806..5864)
                     /locus_tag="VVO18_001712"
     CDS             complement(4806..5864)
                     /locus_tag="VVO18_001712"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000724845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine--N-acetylmuramyl-
                     (pentapeptide) pyrophosphoryl-undecaprenol
                     N-acetylglucosamine transferase"
                     /protein_id="HEU5586822.1"
                     /translation="MKKIVFTGGGTVGHVTLNLLLMPKFIEDGWEVHYIGDKRGIEHQ
                     EILKSGLDVTFHSIATGKLRRYFSWQNMLDVFKVGWGIVQSLFIMLRLRPQTLFSKGG
                     FVSVPPVIAARVSGVPVFIHESDLSMGLANKIAYKFATKMYSTFEQASSLSKVEHVGA
                     VTKVSDQKNPEPDELVDIQSHFNHKLPTVLFVGGSAGARVFNQLVTDHKKELTERYNI
                     INLTGDSSLNELSQNLFRVDYVTDLYQPLMELADIVVTRGGANTIFELLAIAKLHVIV
                     PLGREASRGDQIENAAYFVKKGYAEDLQESDLTLDSLEEKLSHLLSHKEDYQAKMKAS
                     KELKSLADFYQLLKKDLS"
     gene            complement(5866..7218)
                     /locus_tag="VVO18_001713"
     CDS             complement(5866..7218)
                     /locus_tag="VVO18_001713"
                     /EC_number="6.3.2.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000862950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylmuramoyl-L-alanine--D-glutamate
                     ligase"
                     /protein_id="HEU5586823.1"
                     /translation="MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFE
                     DNPAAQCLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYNNPMIEKALAKGIPVLTE
                     VELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIATD
                     KNTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGLFEEYVAAKWNIQNKMAAAD
                     FLVLNFNQDLAKDLASKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPG
                     SHNVENALATIAVAKLRGVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNI
                     LATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKA
                     GVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
                     "
     gene            complement(7322..7963)
                     /locus_tag="VVO18_001714"
     CDS             complement(7322..7963)
                     /locus_tag="VVO18_001714"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000571297.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586824.1"
                     /translation="MIELKNISKKFGSRQLFSDTNLHFEGGKIYALIGTSGCGKTTLL
                     NMIGRLEPYDKGQIIYDGTSLKDIKPSVFFRDYLGYLFQDFGLIESQTVKENLNLGLV
                     GKKLKEKEKISLMKQALNRVNLSYLDLKQPIFELSGGEAQRVALAKIILKDPPLILAD
                     EPTASLDPKNSEELLSILESLKNPNRTIIIATHNPLIWEQVDQVIRVTDLSHR"
     gene            complement(7965..9986)
                     /locus_tag="VVO18_001715"
     CDS             complement(7965..9986)
                     /locus_tag="VVO18_001715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000732428.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU5586825.1"
                     /translation="MKKLFILLSTFFLSFFLAWIIVLRAPQYLYASYDSVSLLRVKKD
                     TQEPTREVFEQELENFANSEQSLIARRIVEPSKDGTTHFIYATYGQGTLPKEFQEASQ
                     ESRERSDPLNSYLLLSGSLTKEKLADKLGDLGYKASADRKIPPYFLAFRILLNPLILI
                     SLAIFGLSFFALVIITRIKEMRAAGIKLFSGQTLLSIMGHSLSTDIKWLLLSALLSFL
                     GGGVVLFSQGLFYPILLATYGFGISFYLLFLLAISILLMLLYLMSLNYKALVPVIKGR
                     LPLKRLMILTLLCQLVAVFTVGYAVKTGLTSYQRLKELEISKQAWQDRADYYQISFGL
                     GDRGKDIENQSKWYAFAKEAIEEEQALYVKDNLLHFANPQGKNEQGETLDTYSPDANT
                     LYVSPSYLDKEKVVVDAETKQKLAHLQKGEFILLLPEHLRSREAELKKVFEERLSYYG
                     KSGEEASAPLDYEMKAHVSYLSMGEKRFVYNNGENPVSTQYLTDPILVVFTPTSTGDS
                     FISLSSWSINAGKQLFIKGYESGLELLKKAGIYEQVSYLKEGRSVYLTRYNEVQTETA
                     TLILGAIVGIASSLLLFYSVNILYFEQFRRDILIKRISGLRFFETHAQYMVSQFASFV
                     FGASLFILSSRDLVIGLLTLLVFLASAVLTLYRQAQKESRVSMTIMKGK"
     gene            complement(10057..10356)
                     /locus_tag="VVO18_001716"
     CDS             complement(10057..10356)
                     /locus_tag="VVO18_001716"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397967.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="HEU5586826.1"
                     /translation="MKTKKHRLLALALISSFTLLGAASAAVQYPDGGVWTYGEGSGGG
                     WAFSNYYHGKKYHYSSIVSRWNGHSDKGEAPAGKTSYAWIWTKWGEQVAFYCDYD"
BASE COUNT         3228 a         2293 c         1829 g         3140 t
ORIGIN      
        1 aaccaagaaa aactgctaat agtaagtaag gataaaaaga aatagtatgc tatataagag
       61 aaaaaaaatc ctataaagaa actagcattg tttgcaatac ttataccata aaattctctt
      121 aaaaaatcaa cctcctttat ctccaaagag aagctaaaac cattactaaa tgcaattaga
      181 aaaatcaata aaaataaagt cgccgtccaa atccccgtac taagagctgc taatttgaaa
      241 ctaaaactgg taaagtgctt aattgatttc agacgaatgc gacactccaa cctattaaaa
      301 tagttattca tcaaataaaa aaagaacaat atatatgtga acggaaagca atatactcca
      361 gtcgtcatat cttgaagtaa aactaagatc cattctaata catttggatg gattgaatat
      421 tggcgacagc gcaataaata tactgtacta gataaaacac aggatagcag taatataaaa
      481 taaaccaata ctgataaaaa atcttttttg taaaattgaa caaattgttt cattatacgt
      541 agtcctctga atgtagaaaa aatgtaccat aaacaaccaa acaactaaca aataaaataa
      601 aagcaagatg cccactaact aaggaaagac tgatatcttt ctgatatccc aaagctaatg
      661 ttgtcacagg ttctaagtaa gatagcccta aaatagccca aaaaatacca ccaaccatca
      721 tataggcaac tgggatgaaa atagctccta tttttttctt cactagcaaa gcactagcta
      781 gtccaaaaat agagaacaca gcgccccaaa ctccatacca gagagtcgtt acaagactat
      841 agagaaactg attggaatca aataattctt ttaaggcacc actataatct ccaatataaa
      901 tttcctgata aggagtcact aaaagattaa ttcctaataa taataaatag gggagaaaaa
      961 agactagaaa agaagaaata attacagtac tacccacaat agccagatac ttctttttag
     1021 aaattcgaca caattgtgct gttagaaaat gactctcagc atcctctatt atctgactag
     1081 aatagggcag tgtacagata agtgcagcta ctaggctaat cggtgaaaat cctcgaatag
     1141 aagaagcggc aaaaaaaatc gataaacctt caattttata aataccattg aaagcaagga
     1201 aatttcctaa actcatgcaa agaagggtca aaaataaaga catataaaat cgaggtgatt
     1261 gaacgactcg tacaagatta caaatgaaaa attccatcct tactcctcct tataataaaa
     1321 atagggtgta gcattctttt ttcatgctac acccacaatc aaccatctct aaggcttact
     1381 ctgacaagta agttaataag aatctggatt ccaagaacct gaagtatgaa ttcttacatg
     1441 atttccaaat tgtggcgcca tagctaatct agtaccagaa ccaatataat tgtcaccacc
     1501 tccattatag tacatgacaa tcctagagcc agaccccaat gaatataccg gggtaatatc
     1561 tgacccacta taggcgctac gaatagaggt atttaacctt ttaccgccac cagtgctgtc
     1621 attattatta attccagcag aggcgttttc tttctcaagc tcactagttg tatccgaacc
     1681 ccaacgcggc aacgttaaat cataatctcc aatctgtcta gctaaaactg taaggagaaa
     1741 caaactagat gcaattgtaa ctacgcaaaa aaggaatata tttttcttct tttcatgaca
     1801 tcgtcctcct aagaagtgat aaacaagata gttgattgat caatttgata catattacat
     1861 tttcattata tcaacaaaag aaagcgttgt caatcatttt atttaaaata ttgtcatatt
     1921 ttaaataaaa tgataaaaga ggctcggtag cctcatctct ctttatctta ctgacctaac
     1981 cttcttgcca attttcttgg tcttctttaa agcgttttag aagatcaagg ccctctggcg
     2041 tgatgtaacc ttcttcttgg gctagatgga taagctcgct atagtttgaa agcgtcacaa
     2101 gtttaacacc agcatctgca aagttcttat ctgcttttgg caattggtag ctgaaaatcg
     2161 ctacaactcc aagcacatct gctccttctc gcttggctgc tgctacagct tcaagaactg
     2221 aaccacccgt tgaaataagg tcttcaacca ctaccatttt ttgaccttga gctacgcgac
     2281 cttcgatttg attaccagct ccgtggtctt ttggtttgct acggatgtag gcaaaaggca
     2341 agtccatctt atcagcaata atggctccgt gtggaatccc tgctgttgca gttcctgcaa
     2401 tcacttctac ttcaggaaag gcttctttga tagcttccac aaaaccattt tcaattaggg
     2461 tacgagtttc tggataggct agtgtcacac gattatcagt gtaaatcggt gacttgatac
     2521 cagatgccca agtgaagggt tcctctggtt tgaggtaaac ggcttggatt ttcaagaggt
     2581 ggctagcgat atctttagca agtgtcatgg tattctcctt ttatttttct aatctagttc
     2641 tttaattcca gtcctgtgtc cattcatcct tgatggtatg ataagctgca acaggatcct
     2701 cagcttgggt aatgggacgt cccactacga tatagtcact gccgatttga taggcatcag
     2761 caggtgtcat gactcgtttt tgatctccaa ctgcagcacc agctggacga atccctggtg
     2821 tcagacagat aaaatctgga ttggtagcct gcttgatgac ttgtacttcc tgagccgagc
     2881 aaacaacacc atccaagcca gcttcagctg tcttcttggc atagtgaatc acagactctt
     2941 gcagactggt ttggatattt tgaaactcct gcatctgagc ttctgacgtt gatgtgagct
     3001 gcgttacagc gatcaatttg gcttgactcc caagaccttc acgcgccgcc ttcatcatct
     3061 ctacaccacc agccgcatgg acattggtca tatccacacc aagctgagac aagaccttca
     3121 tggctgactt gactgtatta ggaatgtcat gaagtttgag atccaaaaag acactatgac
     3181 ccaaaccttt taagtaggac acaatctcag gccccgctgc gtaataaagc tccatcccta
     3241 ccttgagata aaggctttct tctgctggga aaagagctaa aaattccttg accgcctcaa
     3301 aactaggaaa atcaagagca atgattggac gatgttctcg cataggtttc tccttttacc
     3361 tttactagtg agagagtctg gccaacagaa gccacgaaaa aaggaacctg ccaacagcaa
     3421 ggttccacga aaaatgggta gtctccaccc tttcaccgtc taaccttagc tgcctctctg
     3481 gactgcttta aaggtttttt actattctat tatttctact agcacttgtc aagtaaaaac
     3541 atggtcacta aagaactata agagaaaagg taaacctagc gacgcgatga gcgctgggtc
     3601 gtttgatttc gattgctctc ttcctcttgt tttttctgtt cttcttctaa acgtttctgt
     3661 tcttcttcct gttttttctc ggcttcctta gcctcttgtt tggctttttc ctcagcttcc
     3721 ataattaatt tatccgccac agtgtaactg taaattccag cttccatgtc gaccacactc
     3781 ggttctgaca attgaggctt aatcttactg taatatggca gtttcttact catttcagat
     3841 agaggaacca agacttcgtc cgaatcattc atggtcaatc gaattaaatc ggatgtcacc
     3901 ttgcttgggg ctagttccac cttttggata gtcgccttga gttctgggct aatttgagca
     3961 agttctgaga caaaaacctt gatttgttca ctatcattaa agagaactga taaataagtt
     4021 tctggtaaac tgttcagact cacagaacta gtctcaagct gaccactgga aagaatagga
     4081 taatgatttt caccagaaat atagtaggcc acaatatcat attccttgac cttaatagtg
     4141 aacttagttg gaaattgata gacaagttga gctgattcaa cccaatagtt agacttaatc
     4201 tgcttttcat attttgcctt gtctagcaga aggttaatcg tataatccga atcctgaatg
     4261 cctgaagcct gtcgaatatc atcagctgta gtttgcaccg ttccctcaac acgaatatct
     4321 ttcatggtcg cataaggact gagcaagtag gcagagacaa tcaataaaag cagacttgga
     4381 aataaaatcg tgaaggctcg caagatatgg ataccaggaa tctttgcttt ggctggtttt
     4441 tcctttgtag cctttttagc aagcttttta tcctgttcct ccttctcttt agactctggt
     4501 tcttctttct cttctttctc tttgtcagcc tctgaggata ctactttttc ttcagactct
     4561 tccttagctg attctgaatc ttcctggtct gtttcactct cctggtcctg tttatcctct
     4621 gacttctcag attcttctcc cattcgagct tgtctttcct tttccttctc ctcagctaga
     4681 gccgcctctt cttcagcctt cttttttaga tattcttggt ttcgtttctg ccattctgat
     4741 aactctttca attcttcgag ggtttctttg tcctcatttt tcttatcttt tgacatttac
     4801 tttccttatg ataaatcttt tttcaacaat tgataaaaat ctgctagaga tttcaattcc
     4861 ttagaagctt tcatcttagc ttggtaatct tccttgtgac ttagtaagtg agaaagcttc
     4921 tcttccaaac tatccaaggt caaatcgctt tcttgaaggt cttctgcata gcctttctta
     4981 acaaagtaag ctgcattttc aatctggtca ccacgactag cttcacgacc aagtggcaca
     5041 atgacatgca attttgctat cgccaagagc tcaaaaatcg tattggcacc accacgtgtc
     5101 acaacaatat cagccaattc catcaagggt tgatagagat cggtcacata gtcaacacga
     5161 aaaagatttt ggctcaactc attcaggcta gaatctccag ttagattgat aatattgtag
     5221 cgctctgtta gttctttctt atggtctgtc accaattggt taaagacacg agcacctgca
     5281 gaaccgccaa caaacaatac agtcggcaat ttatgattaa agtggctttg aatatccacc
     5341 aattcatctg gttctggatt tttttgatct gaaaccttgg tcactgctcc cacatgctca
     5401 accttagaca aactcgaagc ttgctcaaag gttgaataca tcttagtcgc aaacttatag
     5461 gcgattttat tggccaagcc catagacagg tcagattcgt gaataaagac aggcactcct
     5521 gacacacgcg cagcgataac aggcggtact gagacaaagc ccccctttga aaaaagggtc
     5581 tgtggacgaa gtcgcaacat gataaagagc gattggacga ttccccagcc aactttgaag
     5641 acgtccagca tattttgcca agagaaatag cgacgcaatt ttccagtcgc aatagaatgg
     5701 aaggtgacat ccaaacctga cttaaggatt tcttggtgtt caataccacg cttgtccccg
     5761 atatagtgga cttcccaacc atcttcgatg aacttgggca ttaacaaaag attgagggta
     5821 acgtgtccaa ccgtcccccc acctgtaaag acaatttttt tcatattatt cttttaactc
     5881 cgctactgtg tcgataaaga ggtcgccacg tacttcaaag ttagcataca tatcccagct
     5941 ggcattggca ggactaagaa gaaccacatc tccttgagtc gcaagctcat aggccttgcg
     6001 ggtcgcatct gcaatatctg tcgcctccac ataagcgaca ccagccttgt ctgctgcccg
     6061 tttgacacgt tctgcagatt gacccaggat gaccatcttc ttgagtccag taatgtctgg
     6121 caccaattcg tcaaactcat tgccacggtc caaaccacct gcaatcaaga cgaccttgct
     6181 gttgtcaaat cctgacaagg ctttttgagt agccaagata ttagttgatt tactgtcgtt
     6241 atagaattta acacccttga tgtcatccac aaactggaga cgatgtttga caccaccgaa
     6301 ggctgaaaga gtttccttga tggtttgatt gtccacacca cgaagcttgg ctacagcaat
     6361 agtcgcaagg gcattttcca cattgtggct acctggaaca ccgatttcat tcgctgccat
     6421 gactacttca ccacggaagt agagttgacc atcttccaga taagctccat caaccttttc
     6481 aagtgttgaa aatggtacaa cagtggcttc tgtcttggaa gccaagtctt ttgccaagtc
     6541 ttgattaaag ttcaagacaa ggaaatcagc tgctgccatc ttgttctgga tattccactt
     6601 ggctgctaca tattcctcaa ataatccatg ataatcgata tgagttggca taaggttagt
     6661 aataaccgca atctcaggat ggaattcttg aacacccatg agttggaaag aagaaagttc
     6721 cataacaagc gtgttcttgt ctgtcgctat ttgagcaacc tgactagcag gatagccgat
     6781 atttcctgat aaaagaccat gttgcccagc agcagtcaaa acttccccaa tcatagtcgt
     6841 tgtggttgtc ttaccgttcg atcctgtgat accaataatc ggtgcttctg aaatcaaata
     6901 agccaattcc acctcagtca agactggaat tcccttggcc aaagcctttt caatcatggg
     6961 attgttgtag gggatacctg gatttttcac cataagggca aactcttcat ccaagagttc
     7021 caaaggatgg ccacctgtaa tgaccttgat cccttcttcc agcaaacatt gggcagctgg
     7081 attgtcctcg aatggtttcc catcatttac tgtcacaatg gcacctaact tgtccaacaa
     7141 acgagccgca gattcaccag acttggccaa acctaaaaca agaactttct tatttttaaa
     7201 ttgatctatt actttcatgt ctcgaactcc atttctactc ctactatttt accattttta
     7261 tggaaataaa aaagccacaa agtgtgtttg tgactctttc ttctaactga atcttaccat
     7321 atcatctatg tgataaatcg gtaactcgaa tgacctgatc cacttgctcc caaatcagag
     7381 gattgtgggt cgcaataata atggtccgat tcggattttt taaagattct aggatggaaa
     7441 gtaattcctc agagtttttg gggtctaagg aagcggttgg ttcatctgca agaatcaaag
     7501 gcggatcctt taaaattatc ttcgctagtg caacacgttg tgcttctcct cctgataact
     7561 caaatatagg ttgcttcaaa tccaaataag agaggtttac acggtttaga gcttgtttca
     7621 tcaaagagat tttctctttt tccttcaact ttttaccaac taaacccaga ttgagattct
     7681 ctttgacggt ttggctttca attaagccaa aatcttgaaa taagtatccc aagtaatctc
     7741 taaagaaaac agaaggcttg atgtccttaa gagaagtgcc atcatagatg atttgccctt
     7801 tgtcatatgg ctccaatcgt ccaatcatat tcaagagtgt tgtcttacca cagccacttg
     7861 taccgattaa ggcataaatt ttcccacctt caaaatgaag attcgtatct gaaaatagct
     7921 gacggcttcc aaatttttta gatatattct ttagttcaat catcctattt tcctttcata
     7981 attgtcatag aaacacgaga ttctttctgc gcttgacggt aaagcgtcaa aactgcacta
     8041 gctagaaaga ccaataaagt gagcaagcca atcaccaagt ctcgactgct taaaataaag
     8101 agactagcac caaatacaaa actggcaaat tggctaacca tatactgagc atgtgtttca
     8161 aaaaatcgta aacctgaaat tcgtttaatc aagatatctc ggcggaattg ctcgaaatat
     8221 agaatattga cagaataaaa tagtaacaag gaactagcta tccccacaat agctcctaag
     8281 attaaagttg ctgtttcagt ttgaacttca ttataacgag ttagataaac acttcttcct
     8341 tctttaagat aggatacttg ctcataaatt ccagctttct tcaagagttc tagcccactc
     8401 tcatatcctt tgataaagag ttgttttcca gcattgatag accaactaga taaggatata
     8461 aaactatcac ctgtagaagt cggcgtgaat accactaaaa tcggatcagt caaatactga
     8521 gtggatacgg gattctcacc gttattataa acaaaccgct tttctcccat tgaaagataa
     8581 ctaacgtgcg ctttcatctc ataatccaaa ggagcacttg cctcctcacc agattttcca
     8641 taataactca atctttcttc aaaaactttc ttaagttctg cttctcgaga gcgcaaatgt
     8701 tctgggagca agaggataaa ctcacctttt tggagatggg ctaacttctg tttggtctca
     8761 gcatctacca cgaccttttc cttgtccaaa taactgggac taacatagag cgtattagca
     8821 tctggactat aggtatccag tgtctctccc tgttcatttt ttccttgtgg attggcaaaa
     8881 tggagcagat tatcctttac ataaagagct tgttcttctt cgattgcttc cttggcaaag
     8941 gcataccact tgctctgatt ttctatatct tttcctctat cacctaagcc aaaagaaatt
     9001 tgataatagt ctgctctatc ctgccatgct tgttttgaaa tttcaagttc tttcaatcgt
     9061 tggtaagacg tcaaacctgt cttaacagcg tatcctactg taaagacagc aaccaactga
     9121 cacaataggg ttaaaatcat caggcgttta aggggtaatc tccccttaat aacgggaact
     9181 aatgctttgt aattcaaact cattagataa aggagcatta gtaaaattga aatcgccaat
     9241 aaaaacaaca gatagaaact aatcccaaaa ccataggtgg ctaacaagat aggataaaac
     9301 aaaccttgac taaaaagaac gactccccca cctaggaagg aaaggagggc tgatagaagg
     9361 agccatttga tatcagtaga taaagaatgc cccatgatgg ataagagagt ctgaccagaa
     9421 aagagtttta tacctgctgc tctcatttcc ttaatccgag tgataatcac taaagcaaag
     9481 aaagataagc caaatattgc taaactaatt aaaataaggg gatttagtaa tattcgaaaa
     9541 gcaagaaaat agggcggtat ctttcggtca gcacttgctt tataacccaa atctcctaat
     9601 ttatcggcaa gcttttcttt cgtcaaggaa cctgacaaaa ggagataact atttagcgga
     9661 tcactacgtt cacgactttc ttggctagct tcttggaatt cttttggtaa agttccctga
     9721 ccataagttg cataaataaa gtgagtcgtc ccatccttac tcggctctac aattcttcta
     9781 gctattaaac tctgttctga atttgcaaaa ttctccaatt cctgttcaaa tacctcacgc
     9841 gtcggttcct gagtatcttt tttgacacga agtaaagaaa cggaatcata gcttgcatat
     9901 aaatattgtg gcgcacgtaa gacaataatc caagcaagga agaagctgag aaaaaaagtt
     9961 gataataata tgaatagttt cttcatagta gactccttgt aaacaaaatt ccccctgtaa
    10021 tttcttacaa ggggaacgat ttaaatcaat gaacgattag tcataatcac agtaaaatgc
    10081 tacttgttct ccccatttag tccaaatcca tgcataggag gtttttccag caggagcttc
    10141 tcctttatca gaatgaccat tccatctgct cacgatggat gaataatgat attttttacc
    10201 atgatagtaa tttgaaaaag cccaaccacc tcctgaacct tctccatatg tccatactcc
    10261 tccatctgga tattgtacag cagctgatgc agctcccaat aatgtaaaac ttgaaataag
    10321 agctagagca agtaatctat gttttttcgt tttcatttta ttttttcttt caaaaaaagc
    10381 acaccctgag caacaatgca acaaaataaa tcctcctctc tcttttgttg aaaccgcttt
    10441 cttatgtgat aagaataaca tttttattat ttgttgtcaa ggaaaaaatc
//
LOCUS       DAVHIZ010000058         9676 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.060, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000058 DAVHIZ010000000
VERSION     DAVHIZ010000058.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9676)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9676)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9676
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.060"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            18..6032
                     /locus_tag="VVO18_001717"
     CDS             18..6032
                     /locus_tag="VVO18_001717"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000417171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU5586827.1"
                     /translation="MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQE
                     TAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLVELPNTGSK
                     NERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLL
                     NYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDY
                     NVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTKLINPRKEEKQSSDSQEQL
                     AEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEI
                     QENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTK
                     KTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGEPEVQPTLPEAVVTDKG
                     ETEVQPESPDTVVSDKGEPEQVAPLPEYKGNIEQVKPETPVEKTKEQGPEKTEEVPVK
                     PTEETPVNPNEGTTEGTSIQEAENPVQPAEESTTNSEKVSPDTSSENTGEVSSNPSDS
                     TTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEGTVEGTSNQETEKPVQPAEETQTNS
                     GKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATKPENSGNTTSENGQTEPEPSNGN
                     STEDVSTESNTSNSNGNEEIKQENELDPDKKVEEPEKKLELRNVSDIELYSQTNGTYR
                     QHVSLDGIPENTDTYFVKVKSSAFKDVYIPVASITEEKRNGQSVYKITAKAEKLQQEL
                     ENKYVDNFTFYLDKKAKEENTNFTSFSNLVKAINQNPSGTYHLAASLNANEVELGPDE
                     RSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSLKNVAISGKDDIGSL
                     ANEAQNNTKIKQVHVDGVLAGERGIGGLLAKAEQSSITESSFKGRIINTYETTAAYNI
                     GGMVGHLTGDKALLTKSKATVAISSNTNTSDQTVGGLAGLVDRDAQIQDSYAEGDINN
                     VKHFGRVAGVAGNLWDRTSGDVRYAGSLTNVLSDVNVTNGNAITGYHYNEMKVKDTFS
                     SKANRVYNVTLVKDEVVSKESFEERGTMLDASQIASKKAEINPFILPTVEPLSTSGKK
                     DSDFSKVAYYQAKRNLTYKNIEKLLPFYNKATIVKYGNLVNENSLLYQKELLSAVMMK
                     DNQVITDIVSNKQTANKLLLHYKDDLSEKLDLKYQNDFAKLAEYSLGNTGLLYTPNQF
                     LYDQTSIIKQVLPDLQKVDYHSEAIRKTLGISPNVKQTELYLEDQFAKTKQQLEDSLK
                     KLLSADAGLASANPVTEGYLVDKIKRNKEALLLGLTYLERWYNFSYGQVNVKDLVLYH
                     LDFFGKGNASPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGTTDLFSTLEHYRKV
                     FLPNTSNNDWFKSETKAYIVEEKSTIAEVKAKQKQAGTKYSIGVYDRITSNTWKYRNM
                     VLPLLTLPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDH
                     YDYWYRILDEQSREKLYRTILLYDAYKFGDDTTSGKATAEAKFDSSNPAMKNFFGPVG
                     NKVVHNQHGAYATGDGVYYMSYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGP
                     EFFAKGLLQAPDQPSDATITINSILKHSKSDSTEGSRLQVLDPTERFQNAADLQNYVH
                     NMFDLIYMMEYLEGQSIVNKLSVYQKIEALRKIENQYLTDPADGNDVYATNVVKNLTE
                     DEAKKLTSFDSLIDNNILSAREYKAGTYERNGYFTIKLFAPIFSALSGEKGTPGDLMG
                     RRIAFELLAAKGFKDGMVPYISNQYEEDAKQQGQTINLYGKERGLVTDELVLKKVFDG
                     KYKTWAEFKTAMYQERVDQFGNLKQVTFKDPTKPWPRYGTKTINNVDELQKLMDEAVL
                     QDATGTRWSNYNPETDSAVHKLKRAIFKAYLDQTNDFRSSIFENKK"
     gene            6084..6260
                     /locus_tag="VVO18_001718"
     CDS             6084..6260
                     /locus_tag="VVO18_001718"
                     /inference="COORDINATES: protein motif:HMM:NF012948.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU5586828.1"
                     /translation="MQAGIPPDNEVSYALIYQQETLPATGSSTSALTALGLLAVGSLV
                     LLVHNMTGTVFCSL"
     gene            6480..7331
                     /gene="ylqF"
                     /locus_tag="VVO18_001719"
     CDS             6480..7331
                     /gene="ylqF"
                     /locus_tag="VVO18_001719"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201313.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome biogenesis GTPase YlqF"
                     /protein_id="HEU5586829.1"
                     /translation="MATIQWFPGHMSKARRQVQENLKFVDFVTILVDARLPLSSQNPM
                     LIKIVGDKPKLLILNKADLADPAMTKEWRQYFESQGIQTLAINSKEQVTVKVVTDAAK
                     KLMADKIARQKERGIQIETLRTMIIGIPNAGKSTLMNRLAGKKIAVVGNKPGVTKGQQ
                     WLKTNKDLEILDTPGILWPKFEDETVALKLALTGAIKDQLLPMDEVTIFGINYFKEHY
                     PEKLAERFKQMKIEEEAPVIIMDMTRALGFRDDYDRFYSLFVKEVRDGKLGNYTLDTL
                     EDLDGND"
     gene            7318..8097
                     /locus_tag="VVO18_001720"
     CDS             7318..8097
                     /locus_tag="VVO18_001720"
                     /EC_number="3.1.26.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201102.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease HII"
                     /protein_id="HEU5586830.1"
                     /translation="MATIKEIKELLVTVKELESPIFLDLEKDNRSGVQKEISKRKRAI
                     QAELDENLRLESMLSYEKELYKQGLTLIAGIDEVGRGPLAGPVVAAAVILPKNCKIKG
                     LNDSKKIPKKKHLEIFQAVQDQALSIGIGIIDNQVIDQVNIYEATKLAMQEAISQLSP
                     QPEHLLIDAMKLDLPISQTSIIKGDANSLSIAAASIVAKVTRDELMKEYDQQFPGYDF
                     ATNAGYGTAKHLEGLTKLGVTPIHRTSFEPVKSLVLGKKES"
     gene            8113..9663
                     /locus_tag="VVO18_001721"
     CDS             8113..9663
                     /locus_tag="VVO18_001721"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000392528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chloride channel protein"
                     /protein_id="HEU5586831.1"
                     /translation="MEEQSEIVRSKKEFAFASSTILSQVGRGIIVGLIVGIIVGSFRF
                     LIEKGFHLIQGVYQDQGYLVRNLFVLVLFYILICWLSAKLTRSEKDIKGSGIPQVEAE
                     LKGLMSLNWWGILWKKYVLGILAIASGLMLGREGPSIQLGAVGGKGIAKWLKSSPVEE
                     RSLIASGAAAGLAAAFNAPIAALLFVVEEVYHHFSRFFWVSTLAASIVANFVSLLMFG
                     LTPVLDMPDNIPPMTLDQYWIYLVMGIFLGFSGFLYEKAVLNVGRVYDLIGQKIHLDR
                     AYYPILAFILIIPVGIFLPQIIGGGNQLVLSLTEQNFSFQVLLAYFLIRFIWSMISYG
                     SGLPGGIFLPILALGSLLGALIGAICVNLGLVSQEQFPIFVILGMSGYFGAISKAPLT
                     AMILVTEMVGDIRNLMPLGLVTLVSYIIMDLLKGTPVYEAMLEKMLPEEVSSEGEVTL
                     IEIPVSDKIAGKQVHELNLPHNVLITTQVHNGKSQTVNGSTRMYLGDMIHLVIPKSEI
                     GKVKDLLL"
BASE COUNT         3282 a         1827 c         1997 g         2570 t
ORIGIN      
        1 tatttcaagg aggaataatg gaaaagtatt ttggtgaaaa acaagagcgt ttttcattta
       61 gaaaattatc agtaggactt gtatctgcaa cgatttcaag tttatttttt atgtctgtat
      121 tagctagttc atctgtggat gctcaagaaa ctgcgggagt tcactataaa tatgtggcag
      181 attcagagct atcatcagaa gaaaagaagc agcttgtcta tgatattccg acatacgtgg
      241 agaatgatga tgaaacttat tatcttgttt ataagttaaa ttctcaaaat caactggtgg
      301 aattaccaaa tactggaagc aagaatgaga ggcaagccct agttgctggt gctagcttag
      361 ctgctctggg aattttaatt tttgctgttt ccaagaaaaa ggttaagaat aaaacggtat
      421 tacatttagt attggttgcg ggaatgggaa atggtgtctt agtttcagtc catgctttag
      481 aaaatcatct tttgctaaat tacaatacgg actatgaatt gacctctgga gaaaaattac
      541 ctcttcctaa agagatttca ggttacactt atattggata tatcaaagag ggaaaaacga
      601 cttctgattt tgaagtaagt aatcaagaaa aatcagcagc cactcctaca aaacaacaaa
      661 aggtggatta taatgttaca ccaaattttg tagaccatcc atcaacagta caagctattc
      721 aggaacaaac acctgtttct tcaactaagc cgacagaagt tcaagtagtt gaaaaacctt
      781 tctctactaa attaatcaat ccaagaaaag aagagaaaca atcttcagat tctcaagaac
      841 aattagccga acataagaat ctagaaacga agaaagagga gaagatttct ccaaaggaaa
      901 agactggggt aaatacatta aatccacagg atgaagtttt atcaggtcaa ttgaacaaac
      961 ctgaactctt atatcgtgag gaaactatag agacaaaaat agattttcaa gaagaaattc
     1021 aagaaaatcc tgatttagct gaaggaactg taagagtaaa acaagaaggt aaattaggta
     1081 agaaagttga aatcgtcaga atattctctg taaacaagga agaagtttcg cgagaaattg
     1141 tttcaacttc aacgactgcg cctagtccaa gaatagtcga aaaaggtact aaaaaaactc
     1201 aagttataaa ggaacaacct gagactggtg tagaacataa ggacgtacag tctggagcta
     1261 ttgttgaacc cgcaattcag cctgagttgc ccgaagctgt agtaagtgat aaaggcgaac
     1321 cagaagttca accgacatta cccgaagcag ttgtgaccga caaaggtgag actgaggttc
     1381 aaccagagtc gccagatact gtggtaagtg ataaaggtga accagagcag gtagccccat
     1441 tgccagaata taagggtaat attgagcaag taaaacctga aactccggtt gagaagacca
     1501 aagaacaagg tccagaaaaa actgaagaag ttccagtaaa accaacagaa gaaacaccag
     1561 taaatccaaa tgaaggtact acagaaggaa cctcaattca agaagcagaa aatccagttc
     1621 aacctgcaga agaatcaaca acgaattcag agaaagtatc accagataca tctagcgaaa
     1681 atactgggga agtgtccagt aatcctagtg attcgacaac ctcagttgga gaatcaaata
     1741 aaccagaaca taatgactct aaaaatgaaa attcagaaaa aactgtagaa gaagttccag
     1801 taaatccaaa tgaaggcaca gtagaaggta cctcaaatca agaaacagaa aaaccagttc
     1861 aacctgcaga agaaacacaa acaaactctg ggaaaatagc taacgaaaat actggagaag
     1921 tatccaataa acctagtgat tcaaaaccac cagttgaaga atcaaatcaa ccagaaaaaa
     1981 acggaactgc aacaaaacca gaaaattcag gtaatacaac atcagagaat ggacaaacag
     2041 aaccagaacc atcaaacgga aattcaactg aggatgtttc aaccgaatca aacacatcca
     2101 attcaaatgg aaacgaagaa attaaacaag aaaatgaact agaccctgat aaaaaggtag
     2161 aagaaccaga gaaaaaactc gaattaagaa atgtttctga tattgagttg tatagtcaga
     2221 cgaatggaac ctacagacaa catgtttcat tggatggaat tccagagaat acggatactt
     2281 actttgtcaa ggtaaaatct tcagcattta aagatgtcta tataccagta gcttcaataa
     2341 ctgaagagaa aagaaatggg cagtcagttt ataaaatcac agccaaagct gagaaactcc
     2401 agcaagaact agaaaataaa tatgtcgaca atttcacctt ctacctcgat aagaaggcta
     2461 aagaggaaaa tacaaacttt acttccttta gcaacctggt caaagctata aaccaaaatc
     2521 cctctggaac ctatcattta gcggccagcc tgaatgctaa cgaagtggag cttggtcctg
     2581 atgaaagatc ctatatcaag gacaccttta ctggtcgttt aatcggtgaa aaagatggca
     2641 agaattatgc tatctataat ttgaaaaaac ctctgtttga aaacttgagt ggtgctacag
     2701 tagaaaaact gagtctaaaa aatgttgcta tttcagggaa agatgatatc ggttcactgg
     2761 caaatgaagc tcagaataat acaaaaatta agcaagttca cgtcgatggt gttctggctg
     2821 gtgaacgtgg tatcggtggt ttgctggcta aggctgagca atcaagcatc acagagagca
     2881 gtttcaaggg aagaattatc aacacttatg aaacgactgc tgcctacaat atcggtggta
     2941 tggtcggtca tttgacaggt gacaaggctt tacttactaa gtcaaaagcg acagtagcca
     3001 tttcatctaa cacaaatact tcagatcaga ctgtgggtgg acttgcaggc ctagtagacc
     3061 gagatgcaca gatccaagat agctatgctg aaggtgatat caacaatgtc aagcactttg
     3121 gtagagtcgc tggagtggca ggcaatttgt gggatcgaac ttctggtgat gttaggtatg
     3181 ctggaagttt gaccaatgtt ctcagcgatg ttaatgtaac caacggaaat gccatcactg
     3241 gttaccacta taacgaaatg aaggtaaagg acacattcag cagcaaggcc aacagagtct
     3301 acaatgtcac cttggtcaag gatgaggtcg tcagcaagga atcctttgaa gaaagaggaa
     3361 caatgctaga tgcttctcaa attgcaagca aaaaagcaga aatcaatcct ttcattctac
     3421 caacagtgga gccactttca acaagtggca aaaaagacag tgatttttct aaggtggcct
     3481 attatcaagc taagcgcaac ttgacttata aaaacattga aaaattgcta cctttctaca
     3541 acaaggcaac catcgtcaaa tacggaaacc tggtcaatga gaacagtctt ttatatcaaa
     3601 aagaactctt gtcagcagtc atgatgaagg acaaccaagt catcacagac attgtttcta
     3661 acaaacagac tgcaaacaaa ctcttgcttc actacaagga tgatttatct gagaagctgg
     3721 atctcaaata ccagaatgat ttcgccaaat tagcagaata tagtctgggc aatactggac
     3781 ttctctatac gccaaaccaa ttcctgtatg accaaacctc tatcatcaag caagtcttac
     3841 ctgacttaca aaaggttgac tatcattcag aagccatcag aaagacgctg ggtatttctc
     3901 caaacgtcaa gcaaactgag ctctatctag aagaccagtt cgccaaaaca aaacaacaac
     3961 tggaagacag tttgaaaaaa ctcttgtcag cggatgctgg actggctagt gctaacccag
     4021 tcactgaagg ttatcttgta gataaaatca aacgcaacaa ggaagccttg ctacttggct
     4081 tgacctatct ggaacggtgg tataacttta gctatggtca ggtgaatgtc aaagacctag
     4141 ttctgtacca tttggacttc tttggtaagg ggaatgcttc accattagat actctgattg
     4201 agttgggtaa atctggcttt aacaatcttc tagctaagaa taatgtcgat acttatggta
     4261 tcagtcttgc cagtcaacat ggaacgacag atttgtttag cacgctggaa cattaccgaa
     4321 aagtcttttt accaaataca agcaataatg actggtttaa atcagagact aaggcttaca
     4381 ttgtcgaaga aaaatccact attgcagagg tcaaagccaa gcaaaagcaa gcaggaacta
     4441 agtactctat cggtgtttat gaccgaatta ctagtaatac ttggaaatac cgcaatatgg
     4501 tcttgcctct cctgaccttg ccagagagat ccgtatttgt catctcgacc atgtctagtc
     4561 taggatttgg agcttatgat cgctaccgca gtagtgacca taaagcgggc aaggctctca
     4621 atgattttgt tgaagaaaat gcgcgtgaaa cagccaaacg tcagcgagat cactacgatt
     4681 attggtatcg tattttagat gaacagtcac gcgaaaaact ctatcgtacg attctccttt
     4741 atgatgccta taagtttggg gatgatacaa catcaggaaa agctacagcg gaggctaagt
     4801 ttgatagctc caatccagct atgaagaact tctttggacc agttggcaat aaggtagtac
     4861 acaaccagca tggagcctac gctacagggg acggcgtcta ctatatgtct taccgcatgc
     4921 tggacaagga tggagccatt acttataccc atgaaatgac ccatgattcg gatcaggata
     4981 tttaccttgg tggctatggt cgaagaagtg gcttgggacc agagttcttc gcaaaaggct
     5041 tattgcaagc ccctgaccaa ccaagtgacg caaccattac catcaattct atcttgaaac
     5101 actcaaaatc agatagtaca gagggatccc gtcttcaagt cttggatccg acagagagat
     5161 tccaaaacgc agcagatctt cagaactatg tccataacat gtttgacctt atctacatga
     5221 tggaatatct cgaagggcag tcaatcgtta ataaactaag tgtttaccag aaaatagaag
     5281 ctctcagaaa aatcgagaac caatatctaa cagatcctgc tgatggaaat gatgtttatg
     5341 ctactaatgt tgtgaaaaat ttgactgaag atgaagctaa aaaattgacg agctttgata
     5401 gtttgattga caataacatt ctttcggctc gtgagtataa ggctggcact tatgagagaa
     5461 atggctactt tactataaaa ctctttgcac caatcttttc agcattgagc ggtgagaaag
     5521 gaactccagg tgaccttatg ggacgaagga tagcttttga acttctagct gctaaaggat
     5581 ttaaagatgg tatggtacca tatatttcca accaatacga agaagatgct aaacaacaag
     5641 ggcaaactat caatctttat ggtaaagaac ggggcttggt gaccgatgag cttgttttga
     5701 aaaaggtatt tgatggtaag tataaaactt gggcagaatt taagacagct atgtaccaag
     5761 aacgggtgga tcagtttgga aacttgaagc aggtgacctt taaagatccg acaaaaccat
     5821 ggccaagata tggcacaaag actatcaata atgtggatga attgcagaaa ctaatggatg
     5881 aagctgtttt gcaggatgct acaggtacac gttggagtaa ttataatcca gaaacggaca
     5941 gtgccgtcca taagttgaag agagcaatct ttaaagccta tcttgaccaa acaaatgatt
     6001 ttagaagttc aatttttgag aataaaaaat agtgtttact attaggaaat aaagtttaaa
     6061 aaggtgatga agaacaaacc aagattcaag caggaattcc tcctgataat gaagtaagtt
     6121 atgctcttat ttatcagcag gaaactcttc ctgcaacagg ttcatcaact tctgcgctta
     6181 cagctttagg cctattagct gttggtagtt tagttctttt ggttcataat atgacgggaa
     6241 cagttttttg ctccctctga aaagtcatca tttgatggct tttttctata tagggtaaaa
     6301 gatagggtaa aaggctatca tcggacaaaa taaagaaggc atgatataat ataaagtaga
     6361 tttctatgtc ataaaacaag aactatttgg acatcattca tttgaaaact ctctatgttc
     6421 aaactatagt aaaataaaat aggggatcta aatccttgct acgaaaggaa aaaaactcaa
     6481 tggctactat tcaatggttt cctggtcaca tgtctaaagc tcgtcgacaa gtgcaggaga
     6541 atttaaaatt tgttgatttt gtgacgattt tagttgatgc acgcttacct ctatctagtc
     6601 aaaatcctat gttgatcaag attgttggtg ataaaccaaa actcttgatt ttaaacaagg
     6661 ccgacttggc tgatccagca atgaccaagg aatggcgtca gtattttgaa tcacaaggaa
     6721 tccagacgct agctatcaac tccaaagagc aagtgactgt aaaagttgta acagatgcgg
     6781 ccaagaagct catggctgat aagattgctc gccagaaaga acgtgggatt cagattgaaa
     6841 ccttgcgtac catgattatc gggattccaa acgctggtaa atcaactctg atgaaccgtt
     6901 tggctggtaa aaagattgct gttgttggaa acaagccagg ggtcacaaaa ggtcaacaat
     6961 ggcttaaaac caataaagat ctggaaatct tggatacacc ggggattctc tggcctaagt
     7021 ttgaggatga aactgttgca cttaagttgg cattgactgg agctatcaaa gaccagttgc
     7081 ttcctatgga tgaggttacc atttttggta tcaattattt caaagaacat tatccagaaa
     7141 agctggctga acgcttcaaa caaatgaaaa ttgaagaaga agcgcctgtg attattatgg
     7201 atatgacccg cgccctcggt ttccgtgatg actatgaccg tttttacagt ctcttcgtga
     7261 aggaagtccg tgatggcaaa ctcggtaact ataccttaga tacattggaa gacctcgatg
     7321 gcaacgatta aagaaatcaa agaactcctt gtgacagtca aggagttaga aagccctatt
     7381 tttttagatc ttgaaaagga taatcgctca ggagttcaaa aggaaatcag caagcgtaaa
     7441 agagccattc aagctgaatt agatgaaaat ttgcgcttgg aatccatgct ttcttatgaa
     7501 aaagaacttt ataagcaagg attgacctta attgcaggta ttgatgaggt tggtcgtggt
     7561 cctcttgctg gtcctgtagt cgctgcggcc gttattttac ctaaaaattg taagattaaa
     7621 ggtctcaacg acagcaagaa aattcctaaa aagaaacatc tggagatttt ccaagccgtt
     7681 caagaccaag ccttgtcgat tggaattggt atcatagata atcaggtcat cgaccaagtc
     7741 aatatctatg aagcaaccaa actagccatg caagaagcaa tctcccagct cagccctcaa
     7801 ccagagcacc ttttgattga tgccatgaaa ctggacttgc ccatttcaca aacctccatt
     7861 atcaaaggag atgccaactc cctctctatc gcagcagcat ctatagtagc caaggtaaca
     7921 cgtgatgaat tgatgaagga atacgatcag cagttccctg gctatgattt cgctactaat
     7981 gcaggatatg gcacagctaa acatctggaa ggcctcacaa aactaggagt taccccaatt
     8041 caccgaacca gctttgaacc cgttaaatca ctggttttag gtaaaaaaga aagttaattg
     8101 aaaggaaata ccatggagga acagtcggaa atagtccgtt ctaagaaaga attcgccttt
     8161 gcatccagca ctatactatc ccaagttggt cgaggaatca ttgtcggcct catcgttgga
     8221 attatcgtcg gatcctttcg tttcttaatt gaaaagggct tccacctgat acaaggagtt
     8281 tatcaagatc aagggtactt agtacgcaat ctttttgtac tggttttgtt ttatatactc
     8341 atctgttggc tcagtgccaa actaacacgg tcagaaaaag atattaaagg ctcaggaatt
     8401 cctcaagtcg aagccgaact gaaaggcctc atgtccctca actggtgggg cattctttgg
     8461 aaaaaatatg tgctaggtat tcttgctatt gccagtggac tcatgctggg tcgagaggga
     8521 cccagtattc aacttggagc agttggtggt aaaggaattg ccaagtggct caaatccagt
     8581 ccagtagagg aacgttcctt gattgccagt ggagctgcag caggtttagc cgcagccttt
     8641 aatgctccta ttgcagcact tctctttgtt gtagaagaag tctatcacca tttttcgcgc
     8701 tttttctggg tctcaactct agcagccagc atcgtagcaa actttgtgtc tctactcatg
     8761 ttcggtttga caccagtatt ggatatgcca gataacattc ctcccatgac cctagatcag
     8821 tattggatat atctcgtcat gggaattttc cttggatttt caggctttct ctatgagaaa
     8881 gctgtattaa acgttggaag agtttatgac ttgattggtc aaaaaatcca tttggataga
     8941 gcttattatc ccatcttggc ttttatcctt atcataccag tcggaatctt cttacctcaa
     9001 atcattggtg gcggaaatca gcttgtcctt tctttaactg aacaaaattt tagtttccaa
     9061 gttttattag cttacttttt gatccgcttt atttggagta tgattagcta tggaagtgga
     9121 ctgccaggag gaattttcct ccccatttta gctcttggtt ctttgcttgg tgccttaatt
     9181 ggtgctatct gtgtcaatct tggacttgtc agtcaagagc aattccctat atttgtcatt
     9241 ctaggaatga gtggctattt tggagccata tcaaaagctc ccttaaccgc tatgatcctc
     9301 gtaactgaga tggtaggaga tattcgcaac ctcatgccac ttggtcttgt cactcttgtt
     9361 tcttatatta tcatggattt gctcaaaggt acgccagtct atgaagccat gctggaaaaa
     9421 atgcttccag aagaagtatc tagcgaagga gaagttacac ttatcgaaat accagtttct
     9481 gataaaattg ctgggaaaca agttcatgaa ctcaacttac cacacaacgt cctcatcaca
     9541 actcaagtcc ataatggcaa gagccaaaca gttaacggct caaccagaat gtatctgggt
     9601 gatatgattc acctggttat tccaaaaagt gaaattggaa aagtcaaaga tttgttgttg
     9661 tagtacaatc atttac
//
LOCUS       DAVHIZ010000059         9470 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.061, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000059 DAVHIZ010000000
VERSION     DAVHIZ010000059.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9470)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9470)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9470
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.061"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            544..705
                     /locus_tag="VVO18_001722"
     CDS             544..705
                     /locus_tag="VVO18_001722"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586832.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDPTPAKNQEMKNSFD
                     MAKTQIETD"
     gene            797..2476
                     /locus_tag="VVO18_001723"
                     /pseudo
     CDS             797..2476
                     /locus_tag="VVO18_001723"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
     gene            2744..3310
                     /locus_tag="VVO18_001724"
     CDS             2744..3310
                     /locus_tag="VVO18_001724"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586833.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSRFMFDPGENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESRGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHLDPMFVEIEDVEGYVKEEVGEIQ"
     gene            3632..3820
                     /locus_tag="VVO18_001725"
     CDS             3632..3820
                     /locus_tag="VVO18_001725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HEU5586834.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            3882..4640
                     /locus_tag="VVO18_001726"
     CDS             3882..4640
                     /locus_tag="VVO18_001726"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEU5586835.1"
                     /translation="MVVYIRQSKLPSEVSINKYNAQVGAYLQGEEVILYQSFSEIKEL
                     ISEDIVVDYIMETRALLKMMGLNVPVYDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNGTHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDGRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKSYFEKNEIFKIQQDVIF"
     gene            4698..5552
                     /locus_tag="VVO18_001727"
     CDS             4698..5552
                     /locus_tag="VVO18_001727"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HEU5586836.1"
                     /translation="MLGAIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVA
                     EAIMNGGQKDDFIDAMKKYGRMYPNADYGARFNAWLNSDNREPYNSFGNGSAMCISPC
                     AWIMDCGFYAKTGMWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCNIAEAAYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            5664..6548
                     /locus_tag="VVO18_001728"
     CDS             5664..6548
                     /locus_tag="VVO18_001728"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEU5586837.1"
                     /translation="MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKLLE
                     INQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVIANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            6711..8450
                     /locus_tag="VVO18_001729"
                     /pseudo
     CDS             6711..8450
                     /locus_tag="VVO18_001729"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511339.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
     gene            8725..9027
                     /locus_tag="VVO18_001730"
     CDS             8725..9027
                     /locus_tag="VVO18_001730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586838.1"
                     /translation="MGAARDFLELINHKGLPLFNPLVGDSHVNNRQEYDNTGSGNLQP
                     EKWNETAKQLYNVIMWLIILWNAKPDTPLFNFKDEVIKYKTYEPFESSIKLVSINE"
     gene            9083..>9470
                     /locus_tag="VVO18_001731"
     CDS             9083..>9470
                     /locus_tag="VVO18_001731"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586839.1"
                     /translation="MDGITKDFIKTAKLMKQLWPQLTDKEAIDEVKKYTNGKNTAIFT
                     EVEGDTIVGLALCSLRFDYVEGCKYSPVGFLEGIIVDEEYRLKDIAKNLCTKCEEWAK
                     NKGCKEFASDCTLTNTDSIRFHLNIGF"
BASE COUNT         3323 a         1325 c         2002 g         2820 t
ORIGIN      
        1 gttaccaaga ggatctaatt ttcactgcta cttatgcagt gggaattgga cctttttata
       61 taagcaaatt ctatttcaaa attggttacc aagaaagact tcttttcact gttaagtata
      121 agagggtaat ttatagaatt ttgttacatc aagataaata ttttctgatg gtcaaatttt
      181 aaaaagatta ataactctcg ataaattttg aaccttaaca attgaataga ccaagacaag
      241 gcgttaatta tttttggagc gtaataacct atccgtcaag atctttcggc tgaataattc
      301 ggcaaaaaaa gttctgctaa gcaaaaagaa agtgagcgat aagtaagagt ttgaatatag
      361 ggagggatac cctatccgct atgaagaaaa tgaggataat gatacttcta aggttgaagc
      421 cggctcatcc ggaatagagg cggaggtgag attcctatgt tgctaatcca aagcacttgt
      481 caatgtcaaa aaacttaatt aaacaaataa ttattagata taaaacttta gaggaggtat
      541 atattggaca atgactggaa tggattggct gatttaatag caaatctgat tgcaaaatat
      601 gctggtgctt tagatttaga taatctaccc gatccaacgc cagcaaaaaa tcaagagatg
      661 aaaaatagtt ttgacatggc aaaaacacaa attgagacgg actaataaaa gtgttataat
      721 atacttgaaa tgatagtcca aacttaaatt aaaaaaatta tatatgatat agaaaaatta
      781 tattgaggtt aatactatgt caaaagaaaa aataaaagta tacctctata cacgagtatc
      841 tacgtcaata cagatagagg ggtattcgtt agaggcacaa aaatcacgaa tgaaagcttt
      901 tgctatttac aacgattatg aaattgttgg agagtatgaa gatgccggga agtctggcaa
      961 gtctattgaa ggtagaatac agttcaatcg aatgatggaa gatataaaat ctggaaaaga
     1021 tggagtatct tttgttcttg tgtttaagtt atcaagattt gcaagaaatg ccgctgatgt
     1081 tctttctaca cttcagataa tgcaggatta tggagttaat cttatctgcg ttgaagatgg
     1141 cattgattca tctaaagatg ctgggaaact aatgatttct gttttataag ctgtggctga
     1201 aatagaaaga gaaaacatcc gtattcaaac aatggaaggt cgcattcaaa aagcaaggga
     1261 aggaaaatgg aatggtggct ttgctccgta tggatataaa cttgaagacg gcaagctgtt
     1321 tataaatgag gaagaggcag ttgcaataag aacgattttc gaccagtatg taaatactac
     1381 gataggagct aatgggatat ctaaatactt agagaatcat ggaattagaa aaatcccaag
     1441 acagaatggt aagaatcctt tgtttgatgc aggtcttata agaaagatat taaagaatcc
     1501 tgtatataat gggaaaatag catttggaag aagaacttta gaaaaagttc atggtacaag
     1561 aaatgaatat aagcaggttg aacaagatga atatctaata tctgaaggga tacatgaagc
     1621 tatagtttcc gatgaagttt ggcaagctgc tcaggttaag ctaaaatctc aagcaaagaa
     1681 atatgagcat gtgaataaag gaaaagatac acgcacacac ttgctttctg gaattgtaaa
     1741 atgcccgata tgtggagtgg gaatgtttgg gaacaagtgt atcaagaaaa agaaagatgg
     1801 cacaaagtat aaagattttt attactatgg ttgtaaacat aggcagatga taagaggtca
     1861 taagtgtaca ttcagtaagc aaattagaga agaattgtta gatgatgctg ttgcagaggt
     1921 gattgtcaag atagtaagta atccgaaatt tgcttctatg atgcaagaaa aaatcaacat
     1981 gaaggtggat acctctgaaa tagaaaaaga aatagataat taccaaaagg aattgagaaa
     2041 gagtcattct acaaagttta agctaattga ggaaatagat aatttagatg ttgaagataa
     2101 gcattataag agaaggaaac aggatttaga tgatagacta tatcgtatgt atgacaaaat
     2161 agatgaatta gaatcatcac taattgatgc gaaagcaaag aaacagacta ttgaagctga
     2221 aaagcttaca ggagataaca tatataaggt tctgatctat tttgataagc tctataaagt
     2281 catgaatgat gtagagcgta ggcagttaat ttcagctttg atttctgaaa ttcaagttta
     2341 tgaagaaaaa caatctaacg gacaatggct aaaatccatt acttttaagc taccaattat
     2401 agaagaaaat ctcaacatag gtttggacaa tgatgaacaa gttgaatgtg taagtttatt
     2461 agagaaacgt agttaatcct caaaaggttc cccgaacctt ttgagtccca ctgacgcatc
     2521 acgctgaggc ggtatcactg cttgtacgag ttgaagcatc agcaaagtaa aagtagatgt
     2581 tcagccaatg cgacgaggtg agaccgaagg tcgataaggt gtgttctggg tataggactc
     2641 gtaaagtaag taggaaatat gatgagatga tacagagagc ctgaattggt caggtgacgt
     2701 gcttatttac attagcctga taatgaaaat ggagagatta tcgatggtta tattggaatt
     2761 gtaccaaaat gattattcta aagatttagt agcatttgat tccatagaag atgggaaagc
     2821 ctttgtagct caaatcccgg gatacactct ggaaacagaa gatggttttg aagtggagta
     2881 ttttaatcct aaaaacatac cggattatat ggaaattatt tttaacggaa atattgttcc
     2941 tttatctaga tttatgttcg atcctgggga aaatgtaaac attatttgga aagagatttc
     3001 aaatttatcc ctcaaaaatg atagagtgat cgaaggatat tcaaaaattg atgcatatgt
     3061 cgttaacaac catgaagtta aagcctatgt cgaaacaaga gaaacgaact atcgtaaagc
     3121 aaaagacttc ttagaaagcc gcggatatga aatcgacaga agctttttcg gaagtgaaga
     3181 cggtgaagcg attctttaca gaaaaaaagg gatcgaagtt tggcatttct tgtgtcactt
     3241 agacccaatg tttgtagaga ttgaagatgt agaaggatat gttaaagaag aagttggaga
     3301 gattcaatag tcaaccaaag ttccttgtga gtatatacct ttgctagtaa aagagtcaaa
     3361 acgttataac gaaggggggg aagaaaaccc ttgagtgtaa gtctttttct tgtttagagg
     3421 gaaagtatta gagtagccgc tcataattta tactagattt gataactgat ttgagacaga
     3481 ttttatttct ataaatattg tgaaaatttt ttaataccaa agatttaaag ttactgtgtt
     3541 aaaaatcctc tccactttta aactaatgta ttataaaagc cagttgacac aagtgttaca
     3601 cctgtgatag aattaacttg aggtgatgaa aatggcaacc gataaaaata gaataatgat
     3661 tagcttggat gataaaaatc tagagaaact tgaaaattta gtagaagatg ctagagatag
     3721 aaggggaatg cgactaacaa agtcccaggt tattgaatta ctcctaaata ccgttgatta
     3781 tttcgatgat attatggggg ctatttactc aaaaaaataa gagcaaaatt gctattattt
     3841 tttacaaatt ggtgtaacac tagtgatata ggagtgatga aatggttgtt tatattagac
     3901 aaagtaaatt accaagtgag gtttcaatta ataaatacaa tgctcaagta ggtgcctact
     3961 tacaaggaga agaagttatt ttatatcaat ctttttctga aataaaagag ttaataagtg
     4021 aagatatagt tgtagattat ataatggaga ctagagcatt actaaaaatg atgggcttaa
     4081 acgttccggt ttatgactat cctattgagc ttaaagagtt ttatggtcga aagatttatg
     4141 ctggtatttt aggagagatt gtgaatatac ctgataattg gggaaaattt attaagccta
     4201 aagctggttc aaaagtcttt actggaagag ttgttaatgg aacccatgat ttaataggta
     4261 ttggtctacc tttcgactat cctatatgga ttagtgaggt tgtagaattc atagctgaat
     4321 ggcgttgttt tgtgttagat ggtcgcgtat tagatgttcg accctataca ggtgattatc
     4381 atgcacaatt tgatgcaagt gtaattgatg aagcgatatc atgttggaaa gatgcgccaa
     4441 tagcttatgg actagatatc ggtgttactc gcgatggcag aacacttgtt gttgaagtaa
     4501 atgatggtta tgcattggga aattatggcc tatctccttt aaaatcaatc aattttcata
     4561 gagctaggtg gaaagaaatg gtaaaatcct attttgaaaa aaatgaaatt tttaaaatcc
     4621 aacaggatgt tattttctaa aataaatatg gtagataacc aatataaaaa gcatcaaaat
     4681 gaacaaggag gaatctgatg cttggagcaa ttattggaga tattgtcggt tctgtttacg
     4741 aatggaacaa tatcaaaaca aaggactttc ctttatttcg gaaggactgc ttttttacag
     4801 atgacacggt tatgacctgt gctgttgcag aagcaattat gaatggtgga caaaaagacg
     4861 atttcattga cgcgatgaag aaatatggca gaatgtatcc gaatgctgat tacggtgctc
     4921 ggtttaatgc atggctaaac agcgataacc gtgagcctta taatagcttt gggaatggat
     4981 cagctatgtg tatttctcca tgtgcttgga tcatggactg tggtttttat gcgaaaactg
     5041 gtatgtggcc atcatctaga ggacttacga gtctttctgc agaggtaact cataatcatc
     5101 cagaaggtgt caaaggcgct atggctacag ctgatgctat ctttctatgt cgtttttact
     5161 ttggtggtta ttgtagagag tacgagcaat caattaacga caatcctaca gagtgtaaaa
     5221 gacgaattaa ggattatata gaaaaagaat acgattacaa tctatctcaa actttagatg
     5281 aaatccgtcc taactatcgt tttaacgaaa catgtcagga aactgtccct caagccatta
     5341 tcgcctttct tgaaagtaga gacttcgaag atgcgataag aaatgccatc tcacttggtg
     5401 gcgacagtga tactctcgca gcaatcactt gtaacatagc agaggcagct tacggtattc
     5461 ctgattggat caaggataag gcctattctt acttggatga acccttaaag gatgtagtta
     5521 ggcgatggga aaatagaata aaagcgtatt aatctccagt acgtcagatt tctcttttct
     5581 gtattttcat tgtataatag gattacattt acttgcatac gacgaaatgt aaacatttct
     5641 gtttaaaatt aaggataaaa tcaatgaaaa aagcaatggt aattatcaac cctacttctg
     5701 gtggcgagaa ggctttggat tacaaagaaa agctggagaa taaagcaaaa gaatactttg
     5761 aatatgttga aaccaaaatt accgaaaaag cgctggatgc aacacatttt gctgaagaag
     5821 cttctcgtga gcagtatgat gcagtggttg tgtttggtgg agatggaact gtcaatgaag
     5881 tcatttcagg tattgatgag agagactaca ttcctaagtt agggattatc ccaggcggta
     5941 cgggtaacct cattacaaaa cttttggaaa tcaatcaaga catcgatggc gcaattgacg
     6001 aactggattt tgatttaacc aataagattg atatcggtaa agcaaatgac aactattttg
     6061 gttatatctt tagtatcggt tctctgcctg aggcgattca caatgttgaa atagaggaca
     6121 aaacaaaatt cggtatttta acctatgctg taaataccat gaagtctgtc atgacagatc
     6181 aggtctttaa cattaaggtt gagacagaaa atggaaatta tgttggtgaa gctagccatg
     6241 ttttggtcct tttgacaaat tacttcgctg ataagaaaat ctttgaagaa aacaaggacg
     6301 gctatgccaa cattttgatt ctgaaagatg cctctatatt ctccaaatta tccgtcattc
     6361 ctgatttatt aaaaggggat gttatcgcaa atgataatat cgagtatatc aaagcgcgta
     6421 atattaaaat ctcttcagat agtgaattgg agtcagatgt tgacggagat aaatcagata
     6481 acctacctgt agaaatcaaa gtcctagctc agcgagtaga agtattttca aaaccgaaag
     6541 aggattagta tatagagaaa gcctttttta aggctttttg tatactttaa aagatagttc
     6601 ctttaacaac ggacattcct tgcaaatagt ttacaaaaat agtatactgg attcattgag
     6661 tttgaaaacg tttgcgtaaa atttgaatga atactttagg agacaaattg atggaattga
     6721 gtgctattta ccataggcct gagtcggagt atgcctatct ttataaggat aagaaactcc
     6781 atattcgaat tcgaactaag aaaggggaca ttgaaagcat caacttgcac tatggggacc
     6841 cttttatctt tatggaggag ttttatcagg atacaaaaga aatggtcaag ataacttctg
     6901 gtaccttatt tgaccattgg caggttgaag tgtcagttga ctttgcacgt atccagtatc
     6961 tctttgagct cagagataca gaaggtcaaa atattttgta tggcgataaa gggtgtgtgg
     7021 aaaattctct agaaaatctt catgcaattg ggaatggatt taagttgcct tatcttcatg
     7081 agattgatgc ctgcaaggtt cctgactggg tttcaaatac ggtatggtat cagatatttc
     7141 ctgaaagatt tgccaatggc aatgctctat taaacccaga agggacttta gactgggatt
     7201 catctgtcac acctaagagc gatgatttct ttggtggtga tttacagggg attattgatc
     7261 atatggatta cttgcaagac ttgggtatta ctggactata tctttgtccc atctttgaat
     7321 ctacaagcaa tcacaagtac aatacgacag attactttga aattgaccgt cattttggag
     7381 acaaggagac ctttcgggaa ctggtggatc aagcgcatca tcgtggcatg aaagtcatgc
     7441 tggatgcggt atttaatcat attggttcgc aatctcttca atggaaaaat gtcgtcaaaa
     7501 atggtgaaca gtctgcttat aaggattggt tccatattca acaattccca gtgacaactg
     7561 aaaagctagt taataagaga gacttaccct atcatgtttt tggtttcgag gactatatgc
     7621 ctaagctaaa tacagccaat ccagaggtca agaattatct tttaaaggtt gcgacttatt
     7681 ggattgaaga gtttaatatc gatgcttggc gtttggatgt ggctagtgag attgaccatc
     7741 agttctggaa ggattttcgt aaggcagttt tagctaaaaa tcctgatctt tatatcctag
     7801 gagaagtctg gcatacatct cagccttggc taaatggaga tgagttccat gccgtcatga
     7861 attatccttt atctgatagt atcaaggact atttcttacg aggaattaag aagacagacc
     7921 agttcatcga tgaaatcaat tgagagtcta tgtattacaa gcagcagatt tcagaggtca
     7981 tgtttaatct cttggattca catgatacag agcgaatcct gtggacggcc aatgaagatg
     8041 ttcaactggt taaatcagcc ttagcctttc tcttttaaca aaaaggaaca ccgtgcattt
     8101 attacggaac cgagctagcc ttgactggag gaccagatcc agattgtcgt cgttgtatgc
     8161 cttgggaacg tgtatcaagt gacaatgata tgctgaactt tatgaagagg ctgattaaga
     8221 ttcggaaata cgcgtcagta atcatttcgc atggcaagta tagccttcaa gaaatcaaat
     8281 ctgatctagt agctctggaa tggaaatacg aaggatggat cctcaaagca atattcaacc
     8341 aatcaacaga agattatctt ttagagaaag aagcagtagc actagcaagc aattgccaag
     8401 aattggagaa tcagcttgtc atctctccag atggatttgt gattttctaa aaactagttg
     8461 atgaagatta tggtacattt catatcttat atagtataat aaggctagtt actaaacttg
     8521 taaaggagaa cttaaatgaa ttgtagagga catgaaacaa gacaaagaat tgttagagat
     8581 tttgaagttt agcctaaagc acatattaag ctgttagcaa atcaacaaaa acatagtgat
     8641 gcaggagcaa ctattgaaga tgaatattat gtatttatcg ctgagagtaa aattgatggc
     8701 aagaaggaag ttattcagtg ttgcatgggt gcggcaaggg attttttaga actaattaat
     8761 cacaaagggc tacctctttt taatccgctt gtaggtgatt ctcatgtaaa taatagacaa
     8821 gaatatgaca atacagggag tggaaattta caacctgaaa agtggaatga aactgcaaag
     8881 cagctttata atgttataat gtggttgatt attttatgga atgctaagcc ggatacacct
     8941 ttatttaatt ttaaagacga agtaattaag tataaaacat atgagccttt tgaaagcagt
     9001 ataaaattgg tatcaatcaa tgagtaacaa agtatcagca tgattcgaaa catttacttg
     9061 taatttgcgg aggaacatca atatggatgg aataacaaaa gattttataa aaacggctaa
     9121 actaatgaaa caattatggc cccaattgac cgataaagaa gctattgatg aagtaaaaaa
     9181 atatacgaat ggcaaaaata ctgcaatctt tactgaagtt gaaggtgaca caattgtagg
     9241 tctagcacta tgttcactca gatttgatta tgttgaaggt tgtaaatata gtcctgttgg
     9301 attcttagaa gggattattg ttgacgagga atatcgttta aaggatattg ctaaaaatct
     9361 ctgtacaaaa tgtgaggaat gggcgaaaaa taaaggatgt aaggaatttg caagtgactg
     9421 tactttaacg aatacggatt ctataagatt tcatctcaat attggatttc
//
LOCUS       DAVHIZ010000060         9310 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.062, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000060 DAVHIZ010000000
VERSION     DAVHIZ010000060.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9310)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9310)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9310
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.062"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            206..2866
                     /gene="rrgA"
                     /locus_tag="VVO18_001732"
     CDS             206..2866
                     /gene="rrgA"
                     /locus_tag="VVO18_001732"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757844.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus tip adhesin RrgA"
                     /protein_id="HEU5586840.1"
                     /translation="MKKVRKIFQKAVAGLCCISQLTAFSSIVALAETPETSPAIGKVV
                     IKETGEGGALLGDAVFELKNNTDGTTVSQRTEAQTGEAIFSNIKPGTYTLTEAQPPVG
                     YKPSTKQWTVEVEKNGRTTVQGEQVENREEALSDQYPQTGTYPDVQTPYQIIKVDGSE
                     KNGQHKALNPNPYERVIPEGTLSKRIYQVNNLDDNQYGIELTVSGKTVYERKDKSVPL
                     DVVILLDNSNSMSNIRNKNARRAERAGEATRSLIDKITSDPENRVALVTYASTIFDGT
                     EFTVEKGVADKNGKRLNDSLFWNYDQTSFTTNTKDYSYLKLTNDKNDIVELKNKVPTE
                     AEDHDGNRLMYQFGATFTQKALMKADEILTQQARQNSQKVIFHITDGVPTMSYPINFN
                     HATFAPSYQNQLNAFFSKSPNKDGILLSDFITQATSGEHTIVRGDGQSYQMFTDKTVY
                     EKGAPAAFPVKPEKYSEMKAVGYAVIGDPINGGYIWLNWRESILAYPFNSNTAKITNH
                     GAPTRWYYNGNIAPDGYDVFTVGIGINGDPGTDEATATSFMQSISSKPENYTNVTDTT
                     KILEQLNRYFHTIVTEKKSIENGTITDPMGELIDLQLGTDGRFDPADYTLTANDGSRL
                     ENGQAVGGPQNDGGLLKNAKVFYDTTEKRIRVTGLYLGTGEKVTLTYNVRLNDQFVSN
                     KFYDTNGRTTLHPKEVEKNTVRDFPIPKIRDVRKYPAITIAKEKKLGEIEFIKINKND
                     KKPLRDAVFSLQKQHPDYPDIYGAIDQNGTYQNVRTGEDGKLTFKNLSDGKYRLFENS
                     EPAGYKPVQNKPIVAFQIVNGEVRDVTSIVPQDIPAGYEFTNDKHYITNEPIPPKREY
                     PRTGGIGMLPFYLIGCMMMGGVLLYTRKHP"
     gene            3089..5086
                     /gene="rrgB"
                     /locus_tag="VVO18_001733"
     CDS             3089..5086
                     /gene="rrgB"
                     /locus_tag="VVO18_001733"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000836217.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus major pilin RrgB"
                     /protein_id="HEU5586841.1"
                     /translation="MKSINKFLTMLAALLLTASSLFSAATVFAAGTTTTSVTVHKLLA
                     TDGDMDKIANELETGNYAGNKVGVLPANAKEIAGVMFVWTNTNNEIIDENGQTLGVNI
                     DPQTFKLSGAMPATAMKKLTEAEGAKFNTANLPAAKYKIYEIHSLSTYVGEDGATLTG
                     SKAVPIEIELPLNDVVDAHVYPKNTEAKPKIDKDFKGKANPDTPRVDKDTPVNHQVGD
                     VVEYEIVTKIPALANYATANWSDRMTEGLAFNKGTVKVTVDDVALEAGDYALTEVATG
                     FDLKLTDAGLAKVNDQNAEKTVKITYSATLNDKAIVEVPESNDVTFNYGNNPDHGNTP
                     KPNKPNENGDLTLTKTWVDATGAPIPAGAEATFDLVNAQTGKVVQTVTLTTDKNTVTV
                     NGLDKNTEYKFVERSIKGYSADYQEITTAGEIAVKNWKDENPKPLDPTEPKVVTYGKK
                     FVKVNDKDNRLAGAEFVIANADNAGQYLARKADKVSQEEKQLVVTTKDALDRAVAAYN
                     ALTAQQQTQQEKEKVDKAQAAYNAAVIAANNAFEWVADKDNENVVKLVSDAQGRFEIT
                     GLLAGTYYLEETKQPAGYALLTSRQKFEVTATSYSATGQGIEYTAGSGKDDATKVVNK
                     KITIPQTGGIGTIIFAVAGAVIMGIAVYAYVKNNKDEDQLA"
     gene            5133..6314
                     /gene="rrgC"
                     /locus_tag="VVO18_001734"
     CDS             5133..6314
                     /gene="rrgC"
                     /locus_tag="VVO18_001734"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010963222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus minor pilin RrgC"
                     /protein_id="HEU5586842.1"
                     /translation="MISRIFFVMALCFSLVWGAHAVQAQEDHTLVLQLENYQEVVSQL
                     PSRDGHRLQVWKLDDSYSYDNRVQIVRDLHSWDENKLSSFKKTSFEMTFLENQIEVSH
                     IPNGLYYVRSIIQTDAVSYPAEFLFEMTDQTVEPLVIVAKKADTVTTKVKLIKVDQDH
                     NRLEGVGFKLVSVARDGSEKEVPLIGEYRYSSSGQVGRTLYTDKNGEIVVTNLPLGTY
                     RFKEVEPLAGYTVTTMDTDVQLVDHQLVTITVVNQKLPRGNVDFMKVDGRTNTSLQGA
                     MFKVMKEENGHYTPVLQNGKEVVVASGKDGRFRVEGLEYGTYYLWELQAPTGYVQLTS
                     PVSFTIGKDTRKELVTVVKNNKRPRIDVPDTGEETLYILMLVAILLFGSGYYLTKKTN
                     N"
     gene            6653..7549
                     /gene="srtC-1"
                     /locus_tag="VVO18_001735"
     CDS             6653..7549
                     /gene="srtC-1"
                     /locus_tag="VVO18_001735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-1"
                     /protein_id="HEU5586843.1"
                     /translation="MAKTKKQKRNNLLLGVVFFIGMAVMAYPLVSRLYYRVESNQQIA
                     DFDKEKATLDEADIDERMKLAQAFNDSLNNVVSGDPWSEEMKKKGRAEYARMLEIHER
                     MGHVEIPAIDVDLPVYAGTAEEVLQQGAGHLEGTSLPIGGNSTHAVITAHTGLPTAKM
                     FTDLTKLKVGDKFYVHNIKEVMAYQVDQVKVIEPTNFDDLLIVPGHDYVTLLTCTPYM
                     INTHRLLVRGHRIPYVAEVEEEFIAANKLSHLYRYLFYVAVGLIVILLWIIRRLRKKK
                     RQSERALKALKEATKEVKVEDE"
     gene            7542..8435
                     /gene="srtC-2"
                     /locus_tag="VVO18_001736"
     CDS             7542..8435
                     /gene="srtC-2"
                     /locus_tag="VVO18_001736"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000370515.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-2"
                     /protein_id="HEU5586844.1"
                     /translation="MSKSRYSRKKSVKKKKNPFILLLIFLVGLAVAMYPLVSRYYYRI
                     ESNEVIKEFDETVSQMDKAELEERWRLAQAFNATLKPSEILDPFTDQEKKQGVSEYAN
                     MLKVHERIGYVEIPAIEQEIPMYVGTSEDILQKGAGLLEGASLPVGGENTHTVITAHR
                     GLPTAELFSQLDKMKKGDIFYLHVLDQVLAYQVDQIVTVEPNDFEPVLIQHGQDYATL
                     LTCTPYMINSHRLLVRGKRIPYTAPIAERNRAVRERGQFWLWLLLGAMAVILLLLYRV
                     YRNRRIVKGLEKQLEGRHVKD"
     gene            8422..9273
                     /gene="srtC-3"
                     /locus_tag="VVO18_001737"
     CDS             8422..9273
                     /gene="srtC-3"
                     /locus_tag="VVO18_001737"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091736.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PI-1 pilus system sortase SrtC-3"
                     /protein_id="HEU5586845.1"
                     /translation="MSRTKLRALLGYLLMLVACLIPIYCFGQMVLQSLGQVKGHATFV
                     KSMTTEMYQEQQNHSLAYNQRLASQNRIVDPFLAEGYEVNYQVSDDPDAVYGYLSIPS
                     LEIMEPVYLGADYHHLGMGLAHVDGTPLPLDGTGIRSVIAGHRAEPSHVFFRHLDQLK
                     VGDALYYDNGQEIVEYQMMDTEIILPSEWEKLESVSSKNIMTLITCDPIPTFNKRLLV
                     NFERVAVYQKSDPQTAAVARVAFTKEGQSVSRVATSQWLYRGLVVLAFLGILFVLWKL
                     ARLLRGK"
BASE COUNT         3016 a         1539 c         2179 g         2576 t
ORIGIN      
        1 aagtgtgtca ttgccaggtt gagaagatag ctataacgca cttttatacg cttttgctac
       61 gtttgttagt gaacggatta actcagcatg agataaattt tatcagaata agtaatccgt
      121 ttcttcgtgt atacagattg aaagtaccta tgaatcatag aaggattaac ttgttctatg
      181 aataatgctt aacagggaga cacacatgaa aaaagtaaga aagatatttc agaaggcagt
      241 tgcaggactg tgctgtatat ctcagttgac agctttttct tcgatagttg ctttagcaga
      301 aacgcctgaa accagtccag cgataggaaa agtagtgatt aaggagacag gcgaaggagg
      361 agcgcttcta ggagatgccg tctttgagtt gaaaaacaat acggatggca caactgtttc
      421 gcaaaggaca gaggcgcaaa caggagaagc gatattttca aacataaaac ctgggacata
      481 caccttgaca gaagcccaac ctccagttgg ttataaaccc tctactaaac aatggactgt
      541 tgaagttgag aagaatggtc ggacgactgt ccaaggtgaa caggtagaaa atcgagaaga
      601 ggctctatct gaccagtatc cacaaacagg gacttatcca gatgttcaaa caccttatca
      661 gattattaag gtagatggtt cggaaaaaaa cggacagcac aaggcgttga atccgaatcc
      721 atatgaacgt gtgattccag aaggtacact ttcaaagaga atttatcaag tgaataattt
      781 ggatgataac caatatggaa tcgagttgac ggttagtggt aaaacagtgt atgaacgaaa
      841 agataagtct gtgccgctgg atgtcgttat cttgctcgat aactcaaata gtatgagtaa
      901 cattcgaaac aagaatgctc gacgtgcgga aagagctggt gaggcgacac gttctcttat
      961 tgataaaatt acatctgatc cagaaaatag ggtagcgctt gtgacttatg cttccactat
     1021 ctttgatggg accgagttta cagtagaaaa aggggtagca gataaaaacg gaaaacgatt
     1081 gaatgattct cttttttgga attatgatca gacgagtttt acaaccaata ccaaagatta
     1141 tagttattta aagctgacta atgataagaa tgacattgta gaattaaaaa ataaggtacc
     1201 taccgaggca gaagatcatg atggaaatag attgatgtac caattcggtg ccacttttac
     1261 tcagaaagct ttgatgaagg cagatgagat tttgacacaa caagcgagac aaaatagtca
     1321 aaaagtcatt ttccatatta cggatggtgt cccaactatg tcgtatccga ttaattttaa
     1381 tcatgctacg tttgctccat catatcaaaa tcaactaaat gcatttttta gtaaatctcc
     1441 taataaagat ggaatactat taagtgattt tattacgcaa gcaactagtg gagaacatac
     1501 aattgtacgc ggagatgggc aaagttacca gatgtttaca gataagacag tttatgaaaa
     1561 aggtgctcct gcagctttcc cagttaaacc tgaaaaatat tctgaaatga aggcggttgg
     1621 ttatgcagtt ataggcgatc caattaatgg tggatatatt tggcttaatt ggagagagag
     1681 tattctggct tatccgttta attctaatac tgctaaaatt accaatcatg gtgcccctac
     1741 aagatggtac tataacggga atattgctcc tgatgggtat gatgtcttta cggtaggtat
     1801 tggtattaac ggagatcctg gtacggatga agcaacggct actagtttta tgcaaagtat
     1861 ttctagtaaa cctgaaaact ataccaatgt tactgacacg acaaaaatat tggaacagtt
     1921 gaatcgttat ttccacacca tcgtaactga aaagaaatca attgagaatg gtacgattac
     1981 agatccgatg ggtgagttaa ttgatttgca attgggcaca gatggaagat ttgatccagc
     2041 agattacact ttaactgcaa acgatggtag tcgcttggag aatggacaag ctgtaggtgg
     2101 tccacaaaat gatggtggct tgctaaaaaa tgcaaaagtg ttctatgata cgactgagaa
     2161 aaggattcgt gtaacaggtt tgtaccttgg aacgggtgaa aaagttacat tgacttataa
     2221 tgttcgcttg aatgaccaat ttgtaagcaa taaattctat gacacgaatg gtcgaacaac
     2281 cctacaccct aaggaagtag aaaagaacac agtgcgcgac ttcccgattc ctaagattcg
     2341 tgatgtgcga aaatatccag caattacgat tgcaaaagag aaaaaacttg gtgaaattga
     2401 gtttattaag atcaataaga atgataaaaa accactgaga gatgcggtct ttagtcttca
     2461 aaaacaacat ccggattatc cagatattta tggagctatt gatcaaaatg gcacttatca
     2521 aaatgtgaga acaggtgaag atggtaagtt gacctttaaa aatctgtcag atgggaaata
     2581 tcgattattt gaaaattctg aaccagctgg ttataaaccc gttcaaaata agcctatcgt
     2641 tgccttccaa atagtaaatg gagaagtcag agatgtgact tcaatcgttc cacaagatat
     2701 accagcgggt tacgagttta cgaatgataa gcactatatt accaatgaac ctattcctcc
     2761 aaagagagaa tatcctcgaa ctggtggtat cggaatgttg ccattctatc tgataggttg
     2821 catgatgatg ggaggagttc tattatacac acggaaacat ccgtaaagtg tagaaatgat
     2881 aatatctatg ttctgaacaa tacttttaag aagtagcact caagaagaga tttaagttta
     2941 cttggtgaaa ccagttttct tcgccaagta aaccaccatt gaaaggggag atgttttcga
     3001 aaacttgcac agaaaaagga ttattattgt catgtgtaat tcattacatt gctcacagtt
     3061 gattttaaga gataaataag gagaaatcat gaaatcaatc aacaaatttt taacaatgct
     3121 tgctgcctta ttattgacag cgagtagcct gttttcagct gcaacagttt ttgcggctgg
     3181 gacgacaaca acatctgtta ccgttcataa actattggca acagatgggg atatggataa
     3241 aattgcaaat gagttagaaa caggtaacta tgctggtaat aaagtgggtg ttctacctgc
     3301 aaatgcaaaa gaaattgccg gtgttatgtt cgtttggaca aatactaata atgaaattat
     3361 tgatgaaaat ggccaaactc taggagtgaa tattgatcca caaacattta aactctcagg
     3421 ggcaatgccg gcaactgcaa tgaaaaaatt aacagaagct gaaggagcta aatttaacac
     3481 ggcaaattta ccagctgcta agtataaaat ttatgaaatt cacagtttat caacttatgt
     3541 cggtgaagat ggagcaacct taacaggttc taaagcagtt ccaattgaaa ttgaattacc
     3601 attgaacgat gttgtggatg cgcatgtgta tccaaaaaat acagaagcaa agccaaaaat
     3661 tgataaagat ttcaaaggta aagcaaatcc agatacacca cgtgtagata aagatacacc
     3721 tgtgaaccac caagttggag atgttgtaga gtacgaaatt gttacaaaaa ttccagcact
     3781 tgctaattat gcaacagcaa actggagcga tagaatgact gaaggtttgg cattcaacaa
     3841 aggtacagtg aaagtaactg ttgatgatgt tgcacttgaa gcaggtgatt atgctctaac
     3901 agaagtagca actggttttg atttgaaatt aacagatgct ggtttagcta aagtgaatga
     3961 ccaaaacgct gaaaaaactg tgaaaatcac ttattcggca acattgaatg acaaagcaat
     4021 tgtagaagta ccagaatcta atgatgtaac atttaactat ggtaataatc cagatcacgg
     4081 gaatactcca aagccgaata agccaaatga aaacggcgat ttgacattga ccaagacatg
     4141 ggttgatgct acaggtgcac caattccggc tggagctgaa gcaacgttcg atttggttaa
     4201 tgctcagact ggtaaagttg tacaaactgt aactttgaca acagacaaaa atacagttac
     4261 tgttaacgga ttggataaaa atacagaata taaattcgtt gaacgtagta taaaagggta
     4321 ttcagcagat tatcaagaaa tcactacagc tggagaaatt gctgtcaaga actggaaaga
     4381 cgaaaatcca aaaccacttg atccaacaga gccaaaagtt gttacatatg gtaaaaagtt
     4441 tgtcaaagtt aatgataaag ataatcgttt agctggggca gaatttgtaa ttgcaaatgc
     4501 tgataatgct ggtcaatatt tagcacgtaa agcagataaa gtgagtcaag aagagaagca
     4561 gttggttgtt acaacaaagg atgctttaga tagagcagtt gctgcttata acgctcttac
     4621 tgcacaacaa caaactcagc aagaaaaaga gaaagttgac aaagctcaag ctgcttataa
     4681 tgctgctgtg attgctgcca acaatgcatt tgaatgggtg gcagataagg acaatgaaaa
     4741 tgttgtgaaa ttagtttctg atgcacaagg tcgctttgaa attacaggcc ttcttgcagg
     4801 tacatattac ttagaagaaa caaaacagcc tgctggttat gcattactaa ctagccgtca
     4861 gaaatttgaa gtcactgcaa cttcttattc agcgactgga caaggcattg agtatactgc
     4921 tggttcaggt aaagatgacg ctacaaaagt agtcaacaaa aaaatcacga tcccacaaac
     4981 gggtggtatt ggtacaatta tctttgctgt agcaggggct gtgattatgg gtattgcagt
     5041 gtacgcatat gttaaaaaca acaaagatga ggatcaactt gcttaagtaa gagagaaagg
     5101 agccattgat gacaatgcag aaaatgcaga aaatgattag tcgtatcttc tttgttatgg
     5161 ctctgtgttt ttctcttgta tggggtgcac atgcagtcca agcgcaagaa gatcacacgt
     5221 tggtcttgca attggagaac tatcaggagg tggttagtca attgccatct cgtgatggtc
     5281 atcggttgca ggtatggaag ttggatgatt cgtattccta tgataatcgg gtgcaaattg
     5341 tgagagactt gcattcgtgg gatgagaata aactttcttc tttcaaaaag acttcgtttg
     5401 agatgacctt ccttgagaat cagattgaag tatctcatat tccaaatggt ctttactatg
     5461 ttcgctctat tatccagacg gatgcggttt cttatccagc tgaatttctt tttgaaatga
     5521 cagatcagac ggtagagcct ttggtcattg tagcgaaaaa agcagatacg gtgacaacaa
     5581 aggtgaagct gataaaggtg gatcaagacc acaatcgctt ggagggtgtc ggctttaaat
     5641 tggtatcagt agcaagagat ggttctgaaa aagaggttcc cttgattgga gaataccgtt
     5701 acagttcttc tggtcaagta gggagaactc tctatactga taaaaatgga gagattgttg
     5761 tgacaaatct tcctcttggg acctatcgtt tcaaggaggt ggagccactg gcaggctata
     5821 ctgttacgac gatggatacg gatgtccagt tggtagatca tcagctggtg acgattacgg
     5881 ttgtcaatca gaaattacca cgtggcaatg ttgactttat gaaggtggat ggtaggacca
     5941 atacctctct tcaaggggca atgttcaaag tcatgaaaga agaaaacgga cactatactc
     6001 ctgttcttca aaatggtaag gaagtagttg tggcatcagg gaaagatggt cgtttccgag
     6061 tggaaggtct agagtatggg acatactatt tatgggagct ccaagctcca actggttatg
     6121 ttcaattaac atcgcctgtt tcctttacaa tcgggaaaga tactcgtaag gaactggtaa
     6181 cagtggttaa aaataacaag cgaccacgga ttgatgtgcc agatacaggg gaagaaacct
     6241 tgtatatctt gatgcttgtt gccattttgt tgtttggtag tggctattat cttacgaaaa
     6301 aaacaaataa ctgatattca atgtacatca ttatgaaaaa gatagcaggc tgaagggaag
     6361 accagagtac tctgaggtga tgttaatcag gaatcatggt gatttggcat gaatcataat
     6421 aacggatatg aggctgggca gattgtgcca gcctcattgt gggttattgt ttgtaaaacg
     6481 ataggactgg tctggtaatc attttaggaa tggacaggac tgggattctg atttaaaatg
     6541 gatggtgaat cagaaagaaa tgagattttc tcgtttctct tagcagatag gattgtctgt
     6601 taggaaaagc gataaaatga tgagtttgaa gttaaaggaa tgctgataaa aaatggcaaa
     6661 aacaaaaaag caaaaacgaa acaatctcct attaggagtg gtatttttca ttggaatggc
     6721 ggtaatggcg tatccgctgg tgtctcgctt gtattatcga gtggaatcaa atcaacaaat
     6781 tgctgacttt gataaggaaa aagcaacgtt ggatgaggct gacattgatg aacgaatgaa
     6841 attggcacaa gccttcaatg actctttgaa taatgtagtg agtggcgatc cttggtcgga
     6901 agaaatgaag aaaaaagggc gagcagagta tgcacgcatg ttagaaatcc atgagcggat
     6961 ggggcatgtg gaaatccctg ctattgatgt agatttgccg gtttatgctg gtactgctga
     7021 agaggtattg cagcaaggcg ctggacatct agagggaact tctctaccga tcggaggcaa
     7081 ttcgacccat gcggtgatta cggcacatac aggtttgcca acggctaaga tgtttacgga
     7141 tttgaccaaa cttaaagttg gggataagtt ttatgtgcac aatatcaagg aagtgatggc
     7201 ctatcaagtg gatcaagtaa aggtgattga gccgacgaac tttgatgatt tattgattgt
     7261 accaggtcat gattatgtga ccttgctgac ctgtacgcca tacatgatca atacccatcg
     7321 tctattggtt cgggggcatc ggataccgta cgtagcagag gttgaggaag aatttattgc
     7381 ggcaaacaaa ctcagtcatc tctatcgcta cctgttttat gtggcagttg gtttgattgt
     7441 gattctttta tggattattc gacgcttgcg caagaagaaa cggcaatcag aaagagcttt
     7501 gaaagcattg aaggaagcta ctaaggaagt gaaggtagag gatgagtaag agtagatatt
     7561 cacggaaaaa gagcgtgaaa aagaagaaaa atccgttcat tcttcttctg atttttttgg
     7621 tggggcttgc cgttgcgatg tatcccttgg tgtctcgtta ttattatcgt attgagtcaa
     7681 acgaggttat taaagagttt gatgagacgg tttcccagat ggataaggcg gaacttgagg
     7741 agcgttggcg cttggctcaa gccttcaatg cgaccttgaa accatctgaa atcctcgatc
     7801 cttttacaga tcaggaaaag aaacagggag tttcagaata tgctaacatg ctaaaagttc
     7861 atgagcgtat cggatatgta gaaattcctg cgattgaaca ggaaatcccc atgtatgttg
     7921 gcacaagtga agacattctt cagaaagggg cagggctgtt agaaggggct tcgctgcctg
     7981 ttggaggtga aaatacccat acagtgatca ctgctcacag aggattgcca acggcagaat
     8041 tgttcagtca attggataag atgaagaaag gggatatctt ttatcttcac gttttagacc
     8101 aggttttggc ctatcaagtg gatcagatag tgacggtgga gccgaatgat tttgagcctg
     8161 ttctgattca acatggacaa gattatgcga ctttactgac ttgtacgcca tacatgatta
     8221 acagccaccg tttgttggta cgtgggaaac ggattccata tacagcgccg attgctgagc
     8281 ggaatcgagc ggtgagagag cgtgggcaat tctggttgtg gttattacta ggagcgatgg
     8341 cggtcatcct tctcttgctg tatcgcgtgt atcgtaatcg acggattgtc aaaggactag
     8401 aaaagcaatt ggaggggcgt catgtcaagg actaaactac gagccttatt gggatacttg
     8461 ttgatgttgg tagcctgttt gattcctatt tattgttttg gacagatggt gttgcagtct
     8521 cttggacagg tgaaaggtca tgctacattt gtgaaatcca tgacaactga aatgtaccaa
     8581 gaacaacaga accattctct cgcctacaat caacgcttgg cttcgcaaaa tcgcattgta
     8641 gatccttttt tggcggaggg atatgaggtc aattaccaag tgtctgacga ccctgatgca
     8701 gtctatggtt acttgtctat tccaagtttg gaaatcatgg agccggttta tttgggagca
     8761 gattatcatc atttagggat gggcttggct catgtggatg gtacaccgct gcctctggat
     8821 ggtacaggga ttcgctcagt gattgctggg caccgtgcag agccaagcca tgtctttttc
     8881 cgccatttgg atcagctaaa agttggagat gctctttatt atgataatgg ccaggaaatt
     8941 gtagaatatc agatgatgga cacagagatt attttaccgt cggaatggga aaaattagaa
     9001 tcggttagct ctaaaaatat catgaccttg ataacctgcg atccgattcc tacctttaat
     9061 aaacgcttat tagtgaattt tgaacgagtc gctgtttatc aaaaatcaga tccacaaaca
     9121 gctgcagttg cgagggttgc ttttacgaaa gaaggacaat ctgtatcgcg tgttgcaacc
     9181 tctcaatggt tgtaccgtgg gctagtggta ctggcatttc tgggaatcct gtttgttttg
     9241 tggaagctag cacgtttact acgagggaaa taaaaagaaa tgaaaggaaa gctaaggctg
     9301 ttcctttttc
//
LOCUS       DAVHIZ010000061         9288 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.063, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000061 DAVHIZ010000000
VERSION     DAVHIZ010000061.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9288)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9288)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9288
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.063"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            453..1496
                     /locus_tag="VVO18_001738"
     CDS             453..1496
                     /locus_tag="VVO18_001738"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TIGR00341 family protein"
                     /protein_id="HEU5586846.1"
                     /translation="MTNNKLYSLIEFRNKIYEELELSRSDLAILLCAMLIASIGLNMD
                     STPVIIGAMLISPLMTPILGVGLSLAIFDFKLLRKSFKILAIQILASLIASTLYFYLS
                     PISYASSEIVARTSPTIWDVLIAFVGGIAGIIGARKKETNNIVPGVAIATALMPPLCT
                     VGYAIASANLKFIIGSSYLFLINCSFIVIATYIGVRLMMVKKHYFKDNEEDSKMRRIL
                     LLVAVLLMIPSFISATTLVRETLKKESLKKFISEQFQGYNILKKTYSKKTHTLKLTIS
                     GNYLTEEELDMISSKRGDYGLSDVSVQVSQLSDSEQLSKEELVEYFFQYIKDKEAKEK
                     EKANKFYTESEEQ"
     gene            1663..3750
                     /gene="topA"
                     /locus_tag="VVO18_001739"
     CDS             1663..3750
                     /gene="topA"
                     /locus_tag="VVO18_001739"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179642.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I DNA topoisomerase"
                     /protein_id="HEU5586847.1"
                     /translation="MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGH
                     IRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAIS
                     WHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYS
                     ISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHAS
                     FYGVDGKKMKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAAN
                     KINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGS
                     KYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQM
                     TAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNS
                     KPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTEL
                     GEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEE
                     EMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPS
                     CHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQV
                     VCSKGDYEEEKIK"
     gene            3856..4215
                     /locus_tag="VVO18_001740"
     CDS             3856..4215
                     /locus_tag="VVO18_001740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004258004.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YbaN family protein"
                     /protein_id="HEU5586848.1"
                     /translation="MRLIYLIIGFLSLALAIVGVVLPLLPTTPFLLLSIACFSRSSKR
                     FEDWLYHTKLYQTYVADFRETKSITRERKKKIIVSIYVLMGISIYFAPLLPVKIGLGA
                     LTIFITYYLFKVIPDKE"
     gene            4308..4940
                     /locus_tag="VVO18_001741"
     CDS             4308..4940
                     /locus_tag="VVO18_001741"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000638771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="copper homeostasis protein CutC"
                     /protein_id="HEU5586849.1"
                     /translation="MIYEFCAENVTLLEKAMQAGARRIELCDNLAVGGTTPSYGVTKA
                     AVELAANYDTTIMTMIRPRGGDFVYNDLEIAIMLEDICLTAQAGSQGVVFGALTADKK
                     LDKPNLEKLIAASKGMEIVFHMAFDELSDEDQPEAIDWLSQAGVTRILTRAGVSGDSL
                     EKRFVHYHRILEYAKGKIEILPGGGIDLDNRQTFIDQVGVTQLHGTKVVF"
     gene            4984..5640
                     /locus_tag="VVO18_001742"
     CDS             4984..5640
                     /locus_tag="VVO18_001742"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000461593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="HEU5586850.1"
                     /translation="MFEIFKSYQFNQEKAHDYGFIENSEVWTYSCQILQGDFVMTVSI
                     TADNVNFQVFDQETGDLYPHVHMESMRGSFVGNVREACLEILYQIRKACFDVQDFICH
                     QTKRIMTQVQEKYGNQLEYLWEKSPDTAVLRHEGNQKWYAVLMKISWNKLEKGREGQV
                     EAVNLKHDQVANLLSQKGIYPAFHMSKRYWISVSLDDTLSDEEVLELIEKSWNLTSKK
                     "
     gene            5659..6291
                     /locus_tag="VVO18_001743"
     CDS             5659..6291
                     /locus_tag="VVO18_001743"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001010941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-isopropylmalate synthase"
                     /protein_id="HEU5586851.1"
                     /translation="MNFQLAKYSLLKKFSENIGFTTPEECGAIFKYLIENVKTDRQII
                     YSPHCHDDLGMAVANSLAAVKNGAGRVEGTINGIRERAENAALEEIAVALNIRQDYYQ
                     VETSIVLNETINTSEMVSRFSGIPVPKNKAVVGGNTFSHESGIHQDGVLKNPLTYEII
                     TPELVGVKIPLGKLSGRHAFVEKLRELALDFTEEDIKPLFAKFKALADKK"
     gene            6319..6753
                     /locus_tag="VVO18_001744"
                     /pseudo
     CDS             6319..6753
                     /locus_tag="VVO18_001744"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000225491.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase I"
     gene            6765..7802
                     /gene="leuB"
                     /locus_tag="VVO18_001745"
     CDS             6765..7802
                     /gene="leuB"
                     /locus_tag="VVO18_001745"
                     /EC_number="1.1.1.85"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="HEU5586852.1"
                     /translation="MAKKIVALVGDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRPFG
                     GADIDAAGPPLPDETLKASREADAILLAAIGSPQYDGAAVRPEQGLMDLRKELNLYAN
                     IRPVKIFDSLKYLSPLKPERISGVDFVVVRELTGEIYFGDHILEERKARDINDYSYEE
                     VEWIIRKAFEIARNRRKILTSIDKQNVLATSKLWRKVAEEVAQDFSDVTLEHQLVDSA
                     AMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLGVMPSASHSENGPSLYEPIYGSA
                     PDIAGQGIANPISMILSVAMMLRDSFGRYEDAERIKRAVETSLAAGILTRDIGGQAST
                     KEMTEAIIARL"
     gene            7799..8068
                     /locus_tag="VVO18_001746"
     CDS             7799..8068
                     /locus_tag="VVO18_001746"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1294 domain-containing protein"
                     /protein_id="HEU5586853.1"
                     /translation="MKLDEKITLVLLIWNVIIFLIYGIDKFKARRRAWRIQEKILLIL
                     ALTCGGFGAWLAGITFHHKTRKWYFKTVWFLGMVTTLVALYFIWR"
     gene            8072..8431
                     /locus_tag="VVO18_001747"
     CDS             8072..8431
                     /locus_tag="VVO18_001747"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844630.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="HEU5586854.1"
                     /translation="MAGSSREYAAWALADYGFKVVIAGSFGDIHYNNELNNGMLPIVQ
                     PREVREKLAQLKPTDQVTVDLEQQKIISPVEEFTFEIDSEWKHKFLNSLDDIGITLQY
                     EELIAAYEKQRPAYWQD"
     gene            8593..9216
                     /locus_tag="VVO18_001748"
                     /pseudo
     CDS             8593..9216
                     /locus_tag="VVO18_001748"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002276310.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="translation factor (SUA5)"
BASE COUNT         2868 a         1634 c         2069 g         2717 t
ORIGIN      
        1 ttagtgtaat tgagaaagga gaaatgattg tgattgatgt tggctaggtt atgttcaatg
       61 attcctaccg tctcaaatct tgtcagtaag gaaaaataaa ttcttcaaaa gtagagatta
      121 caaggcttgt ttaagaaaga attcaaagac cttgacaaat aaaaataaaa tggttattat
      181 aagaaatggt ctaaaataga tgatgatact tttcgaaaat ctttttacgt cagctcagct
      241 ttgccttgct gtgttttgag caagctacgg ttagcttccg agtttgattt tcatttacta
      301 gaaatgaaac tgatgagaga tatcagtaga catttgagtc aggatattat ggaaaatgat
      361 aaaaagagct tgtgagattg gcatatcaga ctactaaagt attgagtttg ttaggatttt
      421 agcgactagt tagctgggaa aggaagatat ttgtgacaaa taataaactg tattcgttga
      481 tagaatttag aaataaaata tatgaagaat tagaactttc cagaagtgat ttagcgattt
      541 tactatgtgc catgcttatc gcctctatcg gattaaatat ggattcgact cccgtgatta
      601 ttggagccat gttaatctct cctttgatga cacctattct gggagtgggg ctctctctag
      661 ctatatttga ttttaaattg ttaagaaaat cttttaaaat attagctatt caaattcttg
      721 ccagtctaat agcttcaaca ctttattttt atctttctcc catttcgtat gctagttcgg
      781 agattgttgc tagaacctct ccgactattt gggatgttct cattgctttt gtaggaggga
      841 tagcaggtat tattggtgct aggaaaaaag agaccaataa tattgttcct ggtgttgcta
      901 ttgcaaccgc cttgatgcct cctctttgta cagtaggtta tgctattgct tctgctaatc
      961 taaaatttat cataggctcc tcttacctat tcctcatcaa ttgtagcttt attgtcattg
     1021 cgacttatat aggtgttagg ttgatgatgg ttaagaaaca ttattttaaa gataatgaag
     1081 aagactctaa aatgcgtagg attttgcttc tagttgctgt tttgctgatg attccgagtt
     1141 tcatctctgc aacgacttta gtgagagaaa cgttgaaaaa agagtccctt aagaaattta
     1201 tatcagagca gtttcagggg tataatattt tgaaaaaaac ctattctaaa aagactcata
     1261 ccctaaagct aaccatttca ggaaattatt tgacagaaga agaactcgat atgatttcaa
     1321 gtaagagagg tgactatggt ttaagtgatg tttctgttca agtttcacaa ttgtctgatt
     1381 cagaacaact tagtaaggaa gagctggtgg agtatttctt ccagtatatc aaggataagg
     1441 aagcaaaaga aaaggaaaaa gctaataagt tttatacaga gtctgaggag caataatttc
     1501 ttgagaatag ctggtttttc tcgtgagtct tctatgtata tcaaaggaag actgaggttt
     1561 taagtataaa acttttcttc tattatagta gctaagtctt gacagggttc aaaaaatggt
     1621 ttacacttta taaagtttat tactttgaaa aggtgtgata ctgtggctac ggcaacaaaa
     1681 aagaaaaaat caacagttaa aaaaaatcta gtcatcgtgg agtcgcctgc taaggccaag
     1741 acgattgaaa aatatctagg cagaaactac aaggttttag ccagtgtcgg gcatatccgt
     1801 gatttgaaga aatccagtat gtccgtcgat attgaaaata attatgaacc gcaatatatt
     1861 aatatccgag gaaaaggccc tcttatcaat gacttgaaaa aagaagctaa aaaagctaat
     1921 aaagtttttc tcgcgagtga cccggaccgt gaaggagaag cgatttcttg gcatttggcc
     1981 catattctca acttggatga aaatgatgcc aaccgtgtgg tcttcaatga aatcaccaag
     2041 gatgcagtca aaaatgcttt taaagaacct cgtaagatcg atatggactt ggtcgatgcc
     2101 caacaagctc gtcggatctt ggaccgcttg gtagggtatt cgatttcgcc tattttgtgg
     2161 aagaaggtca agaagggctt gtcagcaggt cgcgttcagt ccattgccct taaactcatc
     2221 attgaccgtg aaaatgaaat caatgccttc cagccagaag aatactggac agttgatgct
     2281 gtctttaaaa agggaaccaa acaatttcat gcttccttct atggagtaga tggtaaaaag
     2341 atgaaactga ccagcaatga cgaggtcaag gaagtcttgt ctcgtctgac tagtaaagac
     2401 ttttcagtag atcaggtgga taagaaagag cgcaagcgca atgctccttt accctatacc
     2461 acttcatcta tgcagatgga tgctgccaat aaaatcaatt tccgtactcg aaaaaccatg
     2521 atggttgccc aacagctcta tgaaggaatt aatattggtt ctggtgttca aggtttgatt
     2581 acctatatgc gtaccgattc gactcgtatc agtcctgtag cgcaaaatga ggcggcaagc
     2641 ttcattacgg atcgttttgg tagtaagtat tctaagcacg gtagcaaggt caaaaacgcg
     2701 tcaggtgctc aggatgccca tgaggctatt cgtccgtcaa gtgtctttaa tacaccagaa
     2761 agcatcgcta agtatctgga caaggatcag ctcaagctat atacccttat ctggaatcgt
     2821 tttgtggcta gccagatgac agcggccgtt tttgatacca tggctgttaa attgtctcaa
     2881 aaaggggttc aatttgctgc caatggtagt caggttaagt ttgatggtta tcttgccatt
     2941 tataatgatt ctgacaagaa taagatgtta ccggacatgg ttgttggaga tgtggtcaaa
     3001 caggtcaata gcaaaccaga gcaacatttc acccaaccgc ctgcccgtta ttctgaagca
     3061 acactgatta aaaccttaga ggaaaatggg gttggacgtc catcaaccta cgcgccaacc
     3121 attgaaacca ttcagaaacg ttattatgtt cgcctggcag ccaaacgttt tgaaccgaca
     3181 gagttgggag aaattgtcaa taagctcatc gttgaatatt tcccagatat cgtaaacgtg
     3241 accttcacag ctgaaatgga aggtaaactg gatgatgtcg aagttggaaa agagcagtgg
     3301 cgacgggtca ttgatgcctt ttacaaacca ttctctaaag aagttgccaa ggctgaagaa
     3361 gaaatggaaa aaatccagat taaggatgaa ccagctggat ttgactgtga agtgtgtggc
     3421 agtccaatgg tcattaaact tggtcgtttt ggtaaattct acgcttgtag caatttccca
     3481 gattgccgtc atacccaagc aatcgtgaaa gagattggtg ttgagtgtcc aagctgtcat
     3541 cagggacaaa ttattgagcg aaaaaccaag cgtaatcgcc tattctatgg ttgcaatcgc
     3601 tatccagaat gtgaatttac ctcttgggac aagcctgttg gtcgtgactg tccaaaatgt
     3661 ggcaacttcc tcatggagaa aaaagtccgt ggtggtggca agcaggttgt ttgtagcaaa
     3721 ggcgactacg aggaagaaaa gattaaataa gaggaggggt ccgaaagtaa atttcaggct
     3781 ccttttggtt agaacttgac aaaatacatc attttatgcg aaactagaag aagattattt
     3841 taactaggag aagttatgcg tcttatctat ctgataattg gttttttatc actggccttg
     3901 gctattgttg gggttgtttt acccttgttg ccgacaacgc ctttcctttt gttgtctatt
     3961 gcttgtttct ccagaagttc caagcgtttc gaagactggc tttatcatac caagctctat
     4021 caaacatatg tagctgattt tcgcgagact aagtctatta cgcgtgaacg aaagaaaaaa
     4081 atcatcgtct ctatctacgt cttgatggga atttctattt attttgcacc tcttttacca
     4141 gtcaaaattg gtctgggtgc tttgaccatc tttatcactt attatctctt caaggtcatt
     4201 ccagacaaag aatagttaaa acagtagtta tttcccttga taaaattgaa agcatattca
     4261 taacaatatg atataataaa tttgaagtaa tattcaagga gaatcaaatg atttacgaat
     4321 tttgtgctga aaatgtgacc ttgcttgaaa aagcgatgca ggctggagct cgtcggattg
     4381 aactctgtga taatctagca gttggtggga caacacccag ctatggagtg actaaggcag
     4441 cggttgaact ggcagctaac tacgatacaa ccatcatgac catgattcgg ccacgtggtg
     4501 gtgactttgt ctataatgac ctagaaattg ctatcatgct agaagacatt tgtttgactg
     4561 ctcaggctgg aagtcaaggg gttgtatttg gagctttaac tgctgataaa aagttggata
     4621 agcctaatct ggaaaagtta attgctgcat caaaaggaat ggaaattgtc tttcacatgg
     4681 cctttgatga actaagtgat gaagatcaac cggaagctat tgactggctc agtcaagccg
     4741 gtgtcactcg tatcctaact cgtgctggtg tgtctggcga ctccttagaa aaacgttttg
     4801 ttcactatca cagaattttg gagtacgcta aaggtaaaat tgaaattcta ccaggtgggg
     4861 ggattgacct tgacaaccgt caaaccttta ttgaccaggt gggggtaaca caattgcatg
     4921 gtactaaggt tgttttttaa aaaatagaaa ggaactgcta gccttgggta gcagttttca
     4981 cttatgtttg aaatttttaa atcctatcaa tttaatcaag aaaaggctca tgattatggt
     5041 tttatagaaa atagcgaagt ctggacatat agttgccaga ttttgcaagg tgactttgtc
     5101 atgactgtgt ccatcactgc tgataatgtg aactttcaag tctttgacca agagactggt
     5161 gacctctatc ctcacgttca tatggaaagc atgaggggaa gttttgtcgg aaatgtccgt
     5221 gaggcttgtc tggagattct ttaccagatt cggaaggctt gttttgatgt gcaagatttt
     5281 atctgtcatc agactaagcg tatcatgact caagttcagg aaaagtatgg aaaccagttg
     5341 gagtatctgt gggaaaaatc gcctgataca gctgtattgc gccatgaagg caatcaaaag
     5401 tggtatgccg tcttgatgaa aatctcttgg aataagctgg aaaagggcag agaaggacaa
     5461 gtggaagcag tcaacctcaa acatgaccaa gtagctaatt tgctttcaca aaaggggatt
     5521 tatccagcct tccatatgag caagcgctac tggattagtg tgtcccttga tgatacttta
     5581 tcagatgaag aagtactgga attgatagaa aaaagttgga acttaacctc taaaaaatga
     5641 aatattttaa taattttcat gaactttcaa ttagctaaat attctttact gaagaaattt
     5701 tcagaaaata taggatttac cacaccagag gaatgtggtg ccatcttcaa atacctgatt
     5761 gagaatgtca agacggatcg tcagatcatc tattcgcctc actgtcatga tgacctcgga
     5821 atggcagtgg caaatagcct tgctgctgtc aagaatggtg caggacgtgt tgaagggact
     5881 atcaatggta ttagggagcg agctgaaaat gctgctttgg aagaaattgc agtggctctc
     5941 aatattcgcc aagattacta ccaagtagaa accagtattg tcctaaatga gaccatcaat
     6001 acgtcagaaa tggtttctcg cttctctggt attccagttc ctaaaaacaa agccgtcgtt
     6061 ggtggcaata ccttctccca cgaatctggt attcaccaag atggagtcct taaaaatcct
     6121 ctcacttatg agatcatcac acctgaattg gttggtgtta agattccgct tggaaaatta
     6181 tctggtcgcc atgcttttgt tgagaaactg agagaattgg ccctagattt tacagaagag
     6241 gatatcaaac cactctttgc taagttcaag gcactggccg ataagaagta agaaatcaca
     6301 gatgcagata ctcgagcttt ggtagctgga accatggttg aaaatccaga aggcttccac
     6361 tttgatgatt tacaacttca aactcatgca gataatgaca ttgaagcgct cgttagccta
     6421 gccaatatgg atggtgagaa agtcgaattt aatgcgacag ggcaaggttc cgttgaagca
     6481 atctttaacg ctatcgataa gttctttaac taatctgttc gtttggtgtc ctacactatc
     6541 aatgcggtaa cagatggaat cgatgcccag gatcgggttt tggtcactgt tgaaaacaga
     6601 gatacagaaa ccatctttaa tgcagcaggg cttgattttg atgtgttgaa ggcttctgct
     6661 attgcctata taaacgctaa tacctttgtt caaaaagaga atgcaggtga gatgggacgc
     6721 agtgtttctt accacgatat gcctagtgtg taaaggagaa ggctatggca aagaaaatag
     6781 tagctctagt aggagacgga attggcccag aaatcatgga ggctggttta gaagttctgg
     6841 aggctctagc tgaaaaaaca ggttttgact atgagattga cagacgaccg ttcggaggtg
     6901 cagatattga tgcagcagga cctcccttac ctgatgaaac ccttaaggca agtagggaag
     6961 cagatgctat cctactagca gctatcggta gtcctcagta tgatggagca gcggttcgcc
     7021 ctgaacaagg cctgatggat ctccgtaagg aactcaatct ttacgctaat attcgtcctg
     7081 taaaaatctt tgacagtctc aagtatttgt caccactcaa accggaacga atttctggtg
     7141 tagactttgt cgtggtgcgt gaattgacag gcgagattta ctttggagat catattcttg
     7201 aagagcgcaa agcgcgtgat atcaacgact atagctatga ggaagtggag tggattattc
     7261 gcaaagcctt tgaaattgca agaaatcgca gaaaaatcct tactagtatc gataagcaaa
     7321 atgttctagc gacctcaaaa ctctggcgga aagtagctga ggaagtcgca caggatttct
     7381 cagatgtaac cttggaacac cagctggtag actcagctgc tatgcttatg attaccaatc
     7441 ctgctaagtt tgatgttatt gtaacggaga atctttttgg agatatttta tctgatgaat
     7501 caagcgtctt atctggtaca cttggggtta tgccatcagc cagtcattct gaaaatggac
     7561 caagtctcta tgaacctatt tacggttcag cacctgatat tgcaggtcaa ggaattgcca
     7621 atcctatttc catgatttta tcagttgcca tgatgttgag agatagtttc ggacgttatg
     7681 aggatgcaga gcgtatcaaa cgtgctgttg agacaagtct ggcggcagga attttaacga
     7741 gagatatagg aggtcaggct tcaacaaagg aaatgacgga agctattatt gcaaggttat
     7801 gaagttagac gaaaaaatta ctctagtcct tttgatttgg aatgtcatca ttttcttgat
     7861 ttatggcatt gacaaattca aggcaagaag aagagcttgg cgcatccaag agaaaatctt
     7921 actcatttta gcccttactt gtggtggttt tggggcctgg ttagctggaa tcacttttca
     7981 ccacaagact cgaaaatggt actttaaaac agtttggttt cttgggatgg tgaccacact
     8041 agtagcctta tattttattt ggaggtaatg gatggcaggg tcttcgaggg aatacgctgc
     8101 ttgggctcta gcggactatg gttttaaggt cgtgattgca ggatctttcg gtgacattca
     8161 ttacaataat gaactcaata atggcatgtt gccaatcgtt cagcctagag aggttagaga
     8221 gaaactagcc cagctaaaac caaccgacca ggtaactgtg gacttggaac aacaaaaaat
     8281 catctcacca gttgaagaat tcaccttcga gatagatagc gagtggaaac ataaattcct
     8341 aaatagtttg gatgatatcg gtattacctt gcagtatgaa gagttgattg ctgcttatga
     8401 aaaacaacga ccagcctact ggcaggatta gaaaaaatag aaaaggaaat atagtaaatt
     8461 gaaataagat gtaaacaaat gaattggagc ttaacatcca tttccagcaa ttttttagaa
     8521 actacagtgg actattctgg attcaacaca ttataaaatt atgacaaaac acattcacaa
     8581 gaaggctacg acattttaaa aggtgagggc ggatgtatcg tttgccctac taaagttggt
     8641 tacattatca tgaccagcaa caaggcagga cttgagcgta agttcgcagc caaagaacgt
     8701 aagcgtaaca aaccaggtgt tgttctctgc ggtagcatgg atgaacttcg cgctttagcg
     8761 caactcaacc cagaaattga agcattctac taaaaacatt ggatgaagat attcttcttg
     8821 gttgtatcct tccttggaaa ccagaagcct ttgaaaaact caaagcatac ggggatggcc
     8881 gtgaagaact tatgactgat gtacgtggta ctagctgttt tgttatcaag tttggaaaag
     8941 caggtgaaca attggctgcc aagctttggg aagaaggtaa aatggtctac gcctcatatg
     9001 cttcaatgac aaaacgattg aaactcgcta tgagagcaag gtgtaatggt gtctatggtc
     9061 gataaggacg gcaaactcat cccagaacaa ggaggagcac gttcaacttc accagcacca
     9121 gttgtgatcc gtaaagggct tgacattgat aaaatcatga tgcacctgtc agatactttt
     9181 aactcatggg actaccgtca ggttgagtat tattaagata aaaaaagaag tctagtgtta
     9241 tgagatatta aagctcctaa cactggactt tttgtttaga atttcttt
//
LOCUS       DAVHIZ010000062         9211 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.064, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000062 DAVHIZ010000000
VERSION     DAVHIZ010000062.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9211)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9211)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9211
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.064"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..213)
                     /locus_tag="VVO18_001749"
     CDS             complement(<1..213)
                     /locus_tag="VVO18_001749"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821501.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="isopentenyl pyrophosphate isomerase"
                     /protein_id="HEU5586855.1"
                     /translation="MLEILKEYLLLEEGDYIFTNNGSPLMITCFNYFLKNRFRKSEIK
                     KDDFVLTAHVFRYSHISLLAELEVPIT"
     gene            complement(566..1480)
                     /locus_tag="VVO18_001750"
     CDS             complement(566..1480)
                     /locus_tag="VVO18_001750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000751419.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEU5586856.1"
                     /translation="MKKTVYKKLGISIIASTLLASQLSTVSALSVISSTGEEYEVSET
                     LQDSPGTNNFSLPNVSPTYGQYYTNQSEVIIGKNDLVKVKNTLQYPYSTSAYVESEFR
                     GVKNGKDVTYRGSANFIKDNVLITAAHNIYKHEFGKDAEELYVTPARTPNSVPFGRIK
                     VKEVRYLKEFRNLNSKDAREYDLALLILEEPIGAKLGTLGLPTSQKNLTGITVTITGY
                     PSYNFKIHQMYTDKKQVLSDDGMFLDYQVDTLEGASGSTVYDASNRVVGVHTLGDGAN
                     QINSAVKLNERNLPFIYSVLKGYSLEGW"
     gene            complement(1630..1896)
                     /locus_tag="VVO18_001751"
                     /pseudo
     CDS             complement(1630..1896)
                     /locus_tag="VVO18_001751"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000060522.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            complement(1921..2232)
                     /locus_tag="VVO18_001752"
     CDS             complement(1921..2232)
                     /locus_tag="VVO18_001752"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004250000.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
                     /protein_id="HEU5586857.1"
                     /translation="MDWDFADTCWEKEPRKYQYVAANYLKAMQSYLKETDLPKLEQLV
                     VTKSWWDTVDILDRVVGSLVYEHPELEEIILILFENLFKPRQLYLQPQNSVLSNLRLA
                     S"
     gene            complement(2157..2399)
                     /locus_tag="VVO18_001753"
                     /pseudo
     CDS             complement(2157..2399)
                     /locus_tag="VVO18_001753"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812384.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="DNA alkylation repair protein"
     gene            complement(2400..3032)
                     /locus_tag="VVO18_001754"
     CDS             complement(2400..3032)
                     /locus_tag="VVO18_001754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000698412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5586858.1"
                     /translation="MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALE
                     LRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYML
                     KTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
                     ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQDEF"
     gene            complement(3046..4041)
                     /locus_tag="VVO18_001755"
     CDS             complement(3046..4041)
                     /locus_tag="VVO18_001755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000743650.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /protein_id="HEU5586859.1"
                     /translation="MKKQAYVIIALTSFLFVFFFSHSLLEILDFDWSIFLHDVEKTEK
                     FVFLLLVFSMSITCLLALFWRGIEELSLRKMQANLKRLLAGQEVVQVADPDLDASFKS
                     LSGKLNLLTEALQKAENHSLAQEEEIIEKERKRIARDLHDTVSQELFAAHMILSGISQ
                     QALKLDREKMQIQLQSVTAILETAQKDLRVLLLHLRPVELEQKSLIEGIQILLKELED
                     KSDLRVSLKQNMTKLPKKIEEHIFRILQELISNTLRHAQASCLDVYLYQTDVELQLKV
                     VDNGIGFRLGSLDDLSYGLRNIKERVEDMAGTVQLLTAPKQGLAVDIRIPLLDKE"
     gene            complement(4038..4736)
                     /locus_tag="VVO18_001756"
     CDS             complement(4038..4736)
                     /locus_tag="VVO18_001756"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001224647.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell wall-active antibiotics response protein"
                     /protein_id="HEU5586860.1"
                     /translation="MRKFKIFLFIEACLLTGALILMVSEHFSRFLLILFLFLLLIRYY
                     TGKEGNNLLLVAATILFFFIVMLNPFVILAIFVAVIYSLFLLYPMMNQEKEQTNLVFE
                     EVVTVKKEKNRWFGNLHHFSSYQTCQFDDINLFRFMGKDTIHLERVILTNHDNVIILR
                     KIVGTTKIIVPVDVEVSLSVNCLYGDLTFFNQPKRALRNEHYHQETKDYLKSNKSVKI
                     FLTTMIGDVEVVRG"
     gene            complement(4814..5824)
                     /locus_tag="VVO18_001757"
     CDS             complement(4814..5824)
                     /locus_tag="VVO18_001757"
                     /EC_number="5.3.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000210649.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type 2 isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="HEU5586861.1"
                     /translation="MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLS
                     TEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAETCGILFVTGSYSAALKNPTDDS
                     FSVKSSHPNLLLGTNIGLDKPVELGFQTVEEMNPVLLQVHVNVMQELLMPEGERKFRS
                     WQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRR
                     SGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRT
                     VLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEANDQMK
                     KA"
     gene            complement(5808..6815)
                     /locus_tag="VVO18_001758"
     CDS             complement(5808..6815)
                     /locus_tag="VVO18_001758"
                     /EC_number="2.7.4.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000562378.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphomevalonate kinase"
                     /protein_id="HEU5586862.1"
                     /translation="MIAVKTCGKLYLAGEYAILEPGQLALIKDIPIYMRAEIAFSDSY
                     RIYSDMFDFAVDLRPNPDYSLIQETIALMGDFLAVRGQNLRPFSLAIYGKMEREGKKF
                     GLGSSGSVVVLVVKALLALYNLSVDQNLLFKLTSAVLLKRGDNGSMGDLACIAAEDLV
                     LYQSFDRQKVAAWLEEENLATVLERDWGFSISQVKPTLECDFLVGWTKEVAVSSHMVQ
                     QIKQNINQNFLTSSKETVVSLVEALEQGKSEKIIEQVEVASKLLEGLSTDIYTPLLRQ
                     LKEASQDLQAVAKSSGAGGGDCGIALSFDAQSTKTLKNRWADLGIELLYQERIGHDDK
                     S"
     gene            complement(6802..7755)
                     /gene="mvaD"
                     /locus_tag="VVO18_001759"
     CDS             complement(6802..7755)
                     /gene="mvaD"
                     /locus_tag="VVO18_001759"
                     /EC_number="4.1.1.33"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000373478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="HEU5586863.1"
                     /translation="MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYT
                     ETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAA
                     GLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEI
                     YPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLK
                     ENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMAFVRQLREKGEACYFTMD
                     AGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC"
     gene            complement(7737..8615)
                     /gene="mvk"
                     /locus_tag="VVO18_001760"
     CDS             complement(7737..8615)
                     /gene="mvk"
                     /locus_tag="VVO18_001760"
                     /EC_number="2.7.1.36"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163319.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="mevalonate kinase"
                     /protein_id="HEU5586864.1"
                     /translation="MTKKVGVGQAHSKIILIGEHAVVYGYPAISLPLLEVEVTCKVVS
                     AESPWRLYEEDTLSMAVYASLEYLDITEACVRCEIDSAIPEKRGMGSSAAISIAAIRA
                     VFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELEMDL
                     SAYLVIADTGVYGHTREAIQVVQNKGKDALPFLHALGELTQQAEVAISQKDAEGLGQI
                     LSQAHLHLKEIGVSSPEADFLVETTLSHGALGAKMSGGGLGGCIIALVTNLTHAQELA
                     ERLEEKGAVQTWIESL"
     gene            complement(8737..9066)
                     /locus_tag="VVO18_001761"
     CDS             complement(8737..9066)
                     /locus_tag="VVO18_001761"
                     /inference="COORDINATES: protein motif:HMM:NF024736.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812596.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5586865.1"
                     /translation="MTRKAYDTDLNDQEWAKIEPYFSKHRTYKWPKRVLVNETLYVTK
                     TGCQWRMLPHDFPLYLMVWSFFHRSMTTGWFQVNGRWYYAYSSGALAVNTTVDGYSVN
                     YNGEWVQ"
BASE COUNT         2735 a         2111 c         1623 g         2742 t
ORIGIN      
        1 tgttataggt acttccaatt cagcaagcaa acttatatgc gaatatctaa aaacatgagc
       61 agtcaataca aaatcatctt tcttaatttc acttttccta aacctgtttt tcaaaaagta
      121 attgaaacaa gttatcatta agggagaacc attatttgta aatatataat caccttcttc
      181 taaaagaaga tattctttta aaatttctaa cactctatca ctaataccaa ttactctata
      241 tgaagctaaa cttttcggac tatccaaaaa cacttcgtta ttggacgatt acattatagt
      301 aaaacgaaat aagaacagga caaatcgatc aggacagtca aatcaatttc taacaatgtt
      361 ttagaagtag aggtgtacta ttatagtttc aatctactat acaagacgaa attgaagaaa
      421 tctttccatt ataaaacgca tattatcaag gtttttaaac acctaataat atgcgttttt
      481 tcctatttta aagactttta tccacctatt atacaaagtt aagtatccat cacagtttac
      541 aattagcctt cattacctaa cccattcacc atccttcaag agagtaacct ttaagaaccg
      601 aataaataaa tggcaaattt cgttcattta atttaactgc actgttaatt tgattagctc
      661 catctcctaa agtatgcact cctactacgc ggttactagc atcataaact gtagatccac
      721 tagccccctc taaagtatca acttggtagt ccaagaacat gccatcatca cttaaaactt
      781 gttttttatc tgtatacatt tgatgaattt taaaattata tgatggatag cctgtgatag
      841 tcacagttat tcctgtcaaa tttttttgac tagtaggaag acccaaagtc cctaattttg
      901 caccaatggg ctcttctaga attaataaag ccaagtcata ttcccttgca tccttagaat
      961 ttaaatttct aaattccttc aaataacgaa cttcttttac ttttatccga ccaaacggca
     1021 cactatttgg agtacgagca ggagtaacat atagttcttc tgcatcttta ccaaactcat
     1081 gtttataaat attatgagca gcagtaataa ggacattatc ctttataaaa ttggcactcc
     1141 ctcgataagt tacatcttta ccatttttca caccacgaaa ttctgactct acataagctg
     1201 atgtagaata aggatattgt aaagtatttt ttaccttaac taaatcattt ttaccaataa
     1261 tgacttctga ctgatttgta taatattgac cataagtcgg tgaaacattg ggaagtgaaa
     1321 aattattagt tcctggacta tcttgtaatg tctcacttac ctcatattct tcacctgtac
     1381 tagaaataac actcaaagca gatactgtcg ataactggct agccaataaa gtactcgcaa
     1441 taattgaaat acccaatttt ttataaacag ttttcttcat tattgtatcc tcctaatgta
     1501 attatagcgt actattctaa atttcttaat ctactataga atcaagaaat ctaccacctt
     1561 ctttaaatac cctccattat cacataaaca ggtaaacttt tcaattaatg actgcgcttt
     1621 tcaatcacgc tagaggtact tacttgcttc tttgatacta agttcagcca ttctttcctt
     1681 gtttttctca ataaagcatg ttacccaagt gggattcgtt ttggagtagt ctcgcagagt
     1741 ccagccaatg gctttattga taaaaaattc tgtttggttc aagttatgaa gtagaatctt
     1801 ttccattaat tgagtattgg tcttctcttt tcttaacaac tggtggtcaa tagcgacacg
     1861 tctcagccag atattatctg ataggctcca ttttatactc aataaaaatc aaagagcaaa
     1921 ctaggaagct agccgcagat tgctcaaaac actgttttga ggttgcagat agagctgacg
     1981 tggtttgaag agattttcga agagtattaa gattatttct tctagttcag ggtgttcata
     2041 caccaaactc cctactactc gatctaggat atctaccgtg tcccaccagg attttgtcac
     2101 gactaactgc tctagcttag gcaaatcggt ttcctttaga taagactgca ttgctttcaa
     2161 atagttagca gccacatatt ggtattttct aggctccttt tcccagcaag tgtctgcaaa
     2221 atcccaatcg ataatctttg tttttttcgc ttctagtaaa tatttttata gagtttattt
     2281 ctttcaggca ccgcaatacc tagaaaagaa aattgatggc gcatataggc ttccatggac
     2341 cttgcttttt tagagtcttt tgctgcttct agctcctcaa gtaaatctgc taaactcatc
     2401 taaaactcat cttgccccac caaatggtgc tgaaaggcat agacagccgc ctgggtacga
     2461 tcgctgactt caagtttggc aagaatgttg gacacgtggg tcttgaccgt cttgagagag
     2521 ataaagaggt catctgcgat gcgctgattt tcgtagccct tggcgatgag ttggagaaca
     2581 tctcgctcac gcgcagtcaa ttcttcatga agttccatat gattgcggtg gtattcaacc
     2641 ttcttgctaa cctcttgctc aatggccagc tcgccagcag ctaccttact gacggcatga
     2701 agcaattcat ctgcactaga agtcttgagc atatagcctt tggcaccagc atctaagact
     2761 ggcatgattt tttcattgtc caaataagag gtcacaatca aaatcttggc ttcaggccat
     2821 tctttaagga ttgctaaggt cgcgtcaatc ccattcatct caggcatgac aatatccatg
     2881 acaatgacat ctggacgcag ttccaaggcc aagtcaatcc cttgagaccc gttggacgcc
     2941 tcacccacaa cttctacatc gtcttggagg tcaaagtagc ttttcaaacc caaacggacc
     3001 atttcatggt catctactag taaaattttc atctttactc ctttatcatt ccttatctaa
     3061 caggggaata cggatatcaa ctgccagccc ttgcttggga gctgtcaaga gttgaactgt
     3121 tccagccata tcttcaaccc tctccttgat atttcgcagt ccataactca agtcgtctaa
     3181 gcttcctaac cggaaaccaa tcccattgtc caccaccttc agttgcaatt caacatctgt
     3241 ctgatagagg tagacatcta ggcaagatgc ctgggcatgg cggagggtat tgctaatcaa
     3301 ctcttgcagg atacggaaga tatgctcctc gattttctta ggcaatttcg tcatattctg
     3361 cttgagacta accctaagat cactcttgtc ctcaagctct tttaagagaa tttgaatccc
     3421 ttctatcaag ctcttctgct ccagttcaac tggtcgcaaa tgcaagagca aaacccgcaa
     3481 atccttctgg gcagtttcta aaatagctgt gacactctgc aactggatct gcatcttttc
     3541 tctatccaat ttcaaagcct gctgactgat acccgataaa atcatgtggg ccgcaaacaa
     3601 ctcctgactg actgtatcgt gcaaatcccg agcaattcgc ttccgttctt tctcgatgat
     3661 ttcctcttcc tgagcaaggc tatgattttc agctttttga agagcttctg tcaaaaggtt
     3721 aagtttacct gataaggact tgaaactggc atccaaatct ggatctgcaa cctgaaccac
     3781 ttcttgccct gccaataaac gcttgagatt agcctgcatt tttcttagag aaagctcttc
     3841 gatccctcgc caaaacaggg ctaagagaca ggttatggac atgctgaaaa ccaacaataa
     3901 aaagacaaat ttttctgttt tttcgacatc gtgcaaaaag atagaccagt caaaatcaag
     3961 tatttccagc aagctgtggg agaaaaaaaa gacaaacagg aaggaggtga gagcaataat
     4021 gacataggct tgttttttca tcctctaacc acctccacat caccaatcat agtggtcaag
     4081 aaaatcttga cactcttgtt actcttgaga tagtcttttg tttcttgatg atagtgttca
     4141 ttgcggaggg ctcgcttggg ctggttgaaa aaagtcaaat ccccatagag acagttaacg
     4201 ctgagactga cttccacatc tacaggtacg atgattttgg tcgttcctac tatctttctg
     4261 aggataatga cattgtcatg attggttaag atgaccctct ccagatgaat agtgtccttg
     4321 cccatgaagc gaaagagatt gatatcatcg aattggcaag tctggtagct tgaaaaatga
     4381 tgaagatttc caaaccaacg atttttctcc ttcttaaccg tcacgacctc ttcaaaaacc
     4441 aaattggtct gctctttttc ctggttcatc atcgggtaaa gaagaaagag gctatagata
     4501 accgcaacaa aaatagctag aatcacaaaa ggattgagca taacgatgaa aaagaagaga
     4561 atggttgccg ctactaaaag aagattattt ccctctttac cagtgtagta gcgaatcaaa
     4621 agcaaaaaga ggaatagtat cagcagaaaa cgcgaaaaat gctctgatac catcaaaatc
     4681 agagctcctg tcagaagaca ggcttcgata aataaaaaga ttttaaattt tctcataggt
     4741 tcatcctctc ccttctattt tatcacaatt caaaaaagtc acctcagtct gaggatggaa
     4801 aaaaaggcgc tggttacgcc tttttcatct gatcatttgc ttcttttaat tttccataaa
     4861 gaagatagtc tactttttgt agatctgcta tggtggcaca gttaagggaa cacataatca
     4921 agcgtagatc tgctttccag ccttggacaa tgccaatcac ttcttcaact gtgtaggttt
     4981 caaccaattc cagaacggtt cgtgacaatc ccacagcctt agcaccaaaa accaagcact
     5041 taatcatatc cagcggattc cgaacccctc cactaaccaa gagttcgacc ttatctttcc
     5101 attcttgggc attgagaagg gcctgcatgg tagactgacc ccattgattg aggtaatcac
     5161 gctggccact acgacggttt tcgatatagg caaagctggt gccaccacga cccgataggt
     5221 ccactgtacg aacaccgaat tcataggctc tttcgattgt cttggcatcc attccaaagc
     5281 ccacttcctt gaggacaata ggaacgggaa tttgcttgct ataatctgct agatgcgatt
     5341 gccagcttct aaacttcctt tctccctcgg gcatgagtaa ttcctgcatg acattgacat
     5401 gcacttgcaa tagaacagga ttcatctctt ctacagtctg aaatcctaac tcgacaggct
     5461 tgtccaatcc aatattggtt ccaaggagga gattgggatg actagacttg acagaaaaag
     5521 aatcatccgt tggatttttg agagctgcgc tataagaacc cgttacaaat aaaataccac
     5581 aggtttccgc cacctgagcc agcttttgat tgatttctct tcccttatta cttccaccag
     5641 tcatggcatt gatataaaaa ggaaagtccc actttcgacc agcaaactct gtcgaaagat
     5701 cgatttcatc cagattgtaa agaggcaagg aagaatgaat cagctccacc tcatcaaagc
     5761 tattatagga acttttctgc tcaagggcat agaggatatg ctcgtcctta cgatttgtcg
     5821 tcatgtccta tcctttcttg atataagagc tcaatcccca gatcggccca acgatttttt
     5881 aaggttttgg ttgattgcgc atcaaaactc agggcgatgc cacagtcacc accaccagca
     5941 ccactactct tggcaacggc ctgcaaatct tgactggctt ctttcaactg tctaagcaaa
     6001 ggcgtgtaaa tatctgtact caagccttct aaaagcttgc tggctacttc tacttgctcg
     6061 ataatctttt ctgatttccc ctgttccaag gcttcgacca aagaaaccac cgtttctttt
     6121 gaggaagtta aaaaattttg attgatattt tgcttgattt gctggaccat gtgactcgat
     6181 acagccactt ccttggtcca tcccactaag aaatcacatt ctaaagttgg tttcacttgt
     6241 gaaattgaaa atccccaatc acgctccaga actgtcgcca agttttcttc ttctaaccaa
     6301 gcagccacct tctggcgatc aaatgactgg tagagaacca aatcctctgc cgcaatacag
     6361 gcaaggtcgc ccatggaacc attgtctcct cgcttaagca agacagcact agtcagcttg
     6421 aacaagagat tctgatcaac cgaaagatta tagagagcca gtaaagcctt gacaaccaag
     6481 acaacgacgc tgccactaga acctagacca aactttttcc cttctcgttc cattttgcca
     6541 tagattgcta gagaaaaagg tcttaaattc tgaccgcgaa cagcgaggaa gtctcccatc
     6601 aaagcaatcg tttcttgaat caagctgtag tcaggattgg gccttaagtc cactgcgaaa
     6661 tcaaacatat ctgaatagat acggtagctg tcagaaaaag caatctcagc cctcatatag
     6721 atgggaatat cctttatcaa agctaactgc cctggctcta aaatagcata ttcacctgcc
     6781 aaatagagtt ttccgcaagt tttaacagca atcatcttga ctcaaatcct ttgtttttga
     6841 cacaatcaag cgataacgct gaccgaaaat ttctgacaaa tgctccaagt ctttctcctg
     6901 acagaagacc ttaacattgg gaccagcatc catggtaaag tagcaggcct ctcctttctc
     6961 acgaagctga cgaacaaagg ccatagcctc ataagaggca tccgtcagat aagaaaaggc
     7021 tggactagca gtctttgtcg tagcatgcat agccagggca tttttctccg ttaattctcc
     7081 aatcttggca aaatcatttt ccttgagata aatcagcata tcctgatagt ccttctcaga
     7141 ctgacgaacc cagtcgtcga aagtcgtcga ggtttccaca caaagtttca tcccgtcacg
     7201 gctagagatt ggttttttct tgtcctctag caccaacata atcatagcta gtttcaagtc
     7261 tgtctctaca gggtaaattt ctccactatc cttatcccag gctcctagtg gtccataaaa
     7321 actccgagaa gaagagcctg aggcaaattt ggcttcctgt gccaactgac ttctatccaa
     7381 tccaagtttg aaataagcat tacaagcctt gaccagggcg gacaaaccac tagaacttga
     7441 ggacaggccc gctgccgtag gcatattgtt ttgagtatcg atacggacaa agccctcacc
     7501 agctggacga taacggtcaa taatcttact catcttggca tgctcgacct cattttgtag
     7561 ctgaccattg atgtaaaatt cgtcagctgt tacattggct ggtaaaggcg acaaggtcgt
     7621 ctctgtatac atattttcca aagttagaga aatactgcta gtagcaggca ccatctcttt
     7681 ttcttttttc tttccccaat atttgataat agcaatattt gcgtaggaac gtactgttac
     7741 aggctctcta tccatgtctg aacagctcct ttctcttcta atctttctgc tagttcttgt
     7801 gcgtgtgtca aattggttac caaggctatg atacaacctc ctagcccacc accgctcatc
     7861 ttggcaccca gagcaccatg gctaagagtc gtttcaacca aaaagtctgc ctcagggcta
     7921 ctgactccaa tttcttttaa atgtaaatgc gcttgactga ggatttgtcc cagtccttca
     7981 gcatcttttt gtgaaatcgc aacttctgct tgctgggtta attctcccaa ggcatgcaaa
     8041 aacggtaggg catccttgcc cttattttga accacttgga tggcttcacg agtatgacca
     8101 taaacacccg tatcggcaat caccaaatag gcggataaat ccatctcaag ttctgtaaat
     8161 cctacgttct tgataaagcg aataggttgg tcactgagac aggtcttagc atccaaacca
     8221 ctaggattca tatgggcaat catctcagct cgattgacca agatttctag tacatcatga
     8281 ggcagatcag cctgatagta gtcaaatacc gcacgaatgg ccgctatgct gatagccgct
     8341 gacgaaccca tcccccgttt ctcagggata gccgagtcaa tctcacaacg aacgcaggct
     8401 tctgtgatat ccaaatactc cagtgaggca taaaccgcca tggacaaggt atcctcctca
     8461 taaaggcgcc aaggactctc tgcagaaact accttacagg tcacctccac ctccaaaaga
     8521 ggcagggaaa tggcaggata accgtaaacg accgcatgtt cccctattaa aattatctta
     8581 ctatgtgcct gaccgacacc aacttttttt gtcatttttt ccttttacta gacgaaaaaa
     8641 cgtcttattt ttcatacaag tattaattct ttcctatcta ttttattata ttttcacaaa
     8701 aaaagcgatt gtttccattc acaatcgctt ctttcattat tgaacccatt cgccattata
     8761 gttgacagaa tagccatcta cggtcgtatt cactgccaag gcacctgagc tataagcgta
     8821 gtaccatctg ccattgacct ggaaccaacc tgtcgtcata gaacgatgaa agaaactcca
     8881 taccattaag taaagaggaa agtcgtgagg gagcatgcgc cattgacaac ctgttttagt
     8941 gacgtacaaa gtctcattaa caagtactcg tttcggccat ttataggtgc ggtgtttgga
     9001 gaaatagggt tcaatcttag cccattcttg atcatttaaa tcagtatcat atgctttgcg
     9061 tgtcataact ctagtttaac atttttttgt gaatagaggt tctaaataat cgaccacgaa
     9121 aatttcttaa gtgaaaaacg ccttatgaag tatgctacgg gaaagttatg cacttaattt
     9181 gacaattcaa gatgtaaaaa tatatactat a
//
LOCUS       DAVHIZ010000063         9074 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.065, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000063 DAVHIZ010000000
VERSION     DAVHIZ010000063.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 9074)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9074)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9074
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.065"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            694..1686
                     /locus_tag="VVO18_001762"
     CDS             694..1686
                     /locus_tag="VVO18_001762"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5586866.1"
                     /translation="MAMIEVEHLQKHFVKIVKEPGLKGALRSFIHPEKQTFEAVKDLT
                     FEVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRINGKIPQDNRQDYVKDIGVV
                     FGQRTQLWWDLALQETYTVLKEIYDVPDSLFHKRMDFLNEVLDLKDFIKDPVRTLSLG
                     QRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLS
                     DIEQLCDRIFMIDKGQEIFDGTVSQLKETFGKMKTLSFELLPGQSHLVSHYEGLSDMT
                     IDRQGNSLNIEFDSSRYQSADIIKQTLSDFEIRDLKMVDTDIEDIIRRFYRKEL"
     gene            1688..2506
                     /locus_tag="VVO18_001763"
     CDS             1688..2506
                     /locus_tag="VVO18_001763"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240175.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-2 family transporter protein"
                     /protein_id="HEU5586867.1"
                     /translation="MIKLWRRYKPFINAGVQELITYRVNFILYRIGDVMGAFVAFYLW
                     KAVFDSSQESLIQGFSMADITLYIIMSFVTNLLTRSDSSFMIGEEVKDGSIIMRLLRP
                     VHFAASYLFTELGSKWLIFISVGLPFLSVIVLMKIISGQGIVEVLGLTVIYLFSLTLA
                     YLINFFFNICFGFSAFVFKNLWGSNLLKTSIVAFMSGSLIPLAFFPKVVSDILSFLPF
                     SSLIYTPVMIIVGKYDASQILQALLLQFFWLLVMVGLSQLIWKRVQSFITIQGG"
     gene            2508..3293
                     /locus_tag="VVO18_001764"
     CDS             2508..3293
                     /locus_tag="VVO18_001764"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003010202.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586868.1"
                     /translation="MKKYQRMHLIFIRQYIKQIMEYKVDFVVGVLGVFLAQGLNLLFL
                     NVIFQHIPFLEGWTFQEIAFIYGFSLIPKGMDHLFFDNLWALGQRLVRKGEFDKYLTR
                     PINPLFHILVETFQIDALGELLVGGILLGTTVTSIVWTLPKFLLFLVCIPFATLIYTS
                     LKIATASIAFWTKQSGAMIYIFYMFNDFAKYPISIYNSLLRWLISFIVPFAFTAYYPA
                     SYFLQEKDVFFNVGGLMLISLVFFVISLKLWDKGLDSYESAGS"
     gene            3332..3610
                     /locus_tag="VVO18_001765"
                     /pseudo
     CDS             3332..3610
                     /locus_tag="VVO18_001765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808742.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family acetyltransferase"
     gene            3547..3792
                     /locus_tag="VVO18_001766"
     CDS             3547..3792
                     /locus_tag="VVO18_001766"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001816931.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586869.1"
                     /translation="MSRRKKAYQGRKIGSQLLATLESEAHKKVGYLQVKTVAEGSNKD
                     YDRTNDFYRGLGFKKLEIFLQLWNPQNPCQILIKKLE"
     gene            4525..>9074
                     /locus_tag="VVO18_001767"
     CDS             4525..>9074
                     /locus_tag="VVO18_001767"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family serine peptidase"
                     /protein_id="HEU5586870.1"
                     /translation="MKKSTVLSLTTAAVILAAYAPNEVVLADTSNSEDALNISDKEKV
                     VLDKETENKEKHEDIHNAIETSQDFKEKKTAVIEGKAVVSKNPVTDNNTSNEEARIKE
                     DSNQSQGDHTDSFVNKNTENPKKEDKVVYIAEFKDKESGEKAIKQLSNLKNTKVLYTY
                     DRIFNGSAIETTPDNLDKIKQIEGITSVERAQKVQPMMNHARKEIGVEEAIDYLKSIN
                     APFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKI
                     PHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQ
                     IFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRAL
                     RKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQT
                     VEFDKVNIGGESFKYRNIGAFFDKNKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLDL
                     RGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGT
                     KSQVFSISGDDGVKLWNMINPDKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVG
                     DEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVIN
                     GKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQ
                     NTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYGS
                     ISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAVTTDSLTDRLKLDETYKDEKSPDGK
                     QIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFESV
                     EEMEALSSNGKKTDFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSKSKTMEGYDDDGK
                     PKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNRTSLDQDPDLFAFNNQGVHAESTSG
                     SKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQKDLKVVS
                     REHFIRGILNSKGNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPATK
                     IRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLIT
                     KDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTYA
                     GEGQGRNRKLDKDGNTIYEISGAGDLRGKIIEVIALDGASNFTKIHRIKFANQADEKG
                     MISYYLVDPDQDSSKYQKLGEIPESKFKNLKNVKDDSLNKETAEVENNLLVDNQSIEG
                     KSLFNIHKTISTIRDFENKDLKKLIKKKYKQEDDFVNGGTRTVERDYKYDDKGNIIAY
                     DDGTDLEYETEKLDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNNYKSIEI
                     KATKYDFHSKTMTFDLYANIND"
BASE COUNT         3065 a         1443 c         1837 g         2729 t
ORIGIN      
        1 atcagaatga taaaattaat caattaatat ctgattacaa acagaatatg aaagcttttt
       61 atatcactat tgaaaaattt atacgagatg atgaaagcct taagtgttat tttacaaagg
      121 ttatttcaag tcgttccaag gtaacaagtc tagatcagat tgaagctgat aaaacgatac
      181 aaagaaaata ttcaagtgag ctaaaaaaat ttattggatt ttataatgag attatttgtg
      241 aggaaaatag tttcctacat gtacgaaaga ggtggtcgag ttgatttagg tagtcggtgc
      301 gtgagttgat aattctcagg gtatggactt ctttttcatg aatgaggtaa aagagcaggt
      361 attgtttaga gacaatcatt ctgagcatat tttctggata gagggagtat ccgattttat
      421 gatcaaagtt aataccgccc tctggtgaga agatgagtag gttggtaatt taaactatta
      481 aacagaattt ttgattaaaa gtattatttc atgagagaaa tcctaatttc acaatccata
      541 ggcaaacgct tgcattctgt tttttattgg actataatag gttggtataa agccttctgt
      601 agtaataaaa tgtagaaggt gtagaaagta aggatttaga atatttgtag ttaaaaacac
      661 aatgttgcta ttccttatga tagggagata gatatggcaa tgatagaagt ggaacatctt
      721 cagaaacatt ttgtgaagat tgttaaggaa ccgggcttga agggggcttt gcgctccttt
      781 attcatcctg aaaagcagac ctttgaagcg gtcaaggatt tgacctttga ggttccaaaa
      841 gggcagattt taggatttat cggggcaaat ggtgctggga agtcgacaac cattaaaatg
      901 ctgacaggaa ttttgaaacc aacatctggt ttttgtcgga ttaacggcaa gattccccag
      961 gacaatcggc aagattatgt caaagatatt ggcgtagtct ttggacaacg cacccagcta
     1021 tggtgggatt tggctctgca agagacctac actgtcttaa aagagattta tgatgtgcca
     1081 gactcgctct ttcataagcg tatggacttt ttgaatgaag tcttggattt gaaggacttt
     1141 atcaaggatc ccgtgcggac tctttcactg ggacaacgga tgcgggcgga tattgcggcc
     1201 tccttgctcc acaatcccaa ggttcttttt ttagatgagc cgaccattgg tttggacgtt
     1261 tcggttaagg ataatattcg tcgggcaatt actcagatca atcaagagga agaaactacc
     1321 attcttttga ccactcacga tttgagtgat attgagcaac tttgtgatcg gattttcatg
     1381 attgacaagg ggcaagagat ttttgatgga acggtgagcc aactcaagga gacctttggt
     1441 aagatgaaga ctctctcttt tgaactgcta ccaggtcaaa gtcatctcgt ctctcactat
     1501 gaaggtctgt ctgatatgac cattgataga caaggaaaca gcctcaacat tgaatttgat
     1561 agttctcgct accagtcagc tgacattatc aagcaaaccc tgtctgattt tgaaatccgc
     1621 gatttgaaga tggtggatac ggatattgag gatattatcc gtcgcttcta ccgaaaggag
     1681 ctctaggatg atcaaattgt ggagacgtta taaacccttt atcaatgcag gggttcagga
     1741 gttgattact taccgagtca actttattct ctatcggatt ggcgatgtca tgggggcttt
     1801 tgtggccttt tatctctgga aggctgtctt tgattcttcg caagagtctt tgattcaggg
     1861 ctttagtatg gcggatatca ccctctacat catcatgagt tttgtgacca atcttctgac
     1921 tagatccgat tcgtccttta tgattgggga ggaggtcaag gatggctcca ttatcatgcg
     1981 tttgttgcga ccagtgcatt ttgcggcctc ctatcttttc accgagcttg gttccaagtg
     2041 gttgattttt atcagcgttg gccttccatt tttaagtgtc attgtcttga tgaaaatcat
     2101 atcgggtcaa ggtattgtag aggtgctagg attaactgtc atttatcttt ttagcttaac
     2161 gctcgcctat ctgattaact ttttctttaa tatttgcttt ggattttcag cctttgtgtt
     2221 taaaaatctt tggggttcca acctacttaa gacttccata gtggctttta tgtcggggag
     2281 tttgattccc ttggcattct ttccaaaggt tgtttcagat attctctcct ttttgccttt
     2341 ttcatccttg atttatactc cagttatgat cattgttgga aaatacgatg ccagtcagat
     2401 tcttcaggca ctccttttgc agttcttctg gctcttagtg atggtgggat tgtctcagtt
     2461 gatttggaaa cgggtccagt cctttatcac cattcaagga ggttagtatg aaaaaatatc
     2521 aacgaatgca tctgattttt atcagacaat acatcaaaca aatcatggaa tataaggtgg
     2581 attttgtggt tggtgttttg ggagtctttc tggctcaagg cttgaatctc ttgtttctca
     2641 atgtcatctt tcaacatatt ccattcctag aaggctggac ctttcaagag atagctttca
     2701 tttatggatt ttccttgatt cccaagggaa tggaccatct cttttttgac aatctctggg
     2761 cactagggca acgcctagtc agaaaagggg agtttgacaa gtatctgact cgtcccatca
     2821 atcctctctt tcacatccta gttgaaacct ttcagattga tgccttgggt gaactcttag
     2881 tcggtggtat tttattggga acaacagtga ccagcattgt ttggactctt ccaaaattcc
     2941 tgcttttcct agtttgtatt ccttttgcga ccttgattta tacttctctt aaaatcgcaa
     3001 cagccagtat cgccttttgg actaagcagt caggcgccat gatttacatc ttctatatgt
     3061 tcaatgactt tgctaagtat ccgatttcta tttacaattc tcttcttcgt tggttgatta
     3121 gctttatcgt gcctttcgcc tttacagcct actatccagc tagctatttc ttacaggaaa
     3181 aggatgtgtt ctttaacgta ggaggtttga tgttgatttc tctggttttc tttgttattt
     3241 cccttaaact ttgggataag ggcttagatt cctacgaaag tgcgggttcg taaaagctaa
     3301 agtaagacta aaatcaagaa aggaacttat gatgtttgta attgaagaag tcaaggatga
     3361 aaatcaaaaa aaggcagttg tcgctgaggt tttgaaggat ttgccagaat ggtttggaat
     3421 cccagaaagc acataagcct atataaaagg aaccacgaca ctgcaagttt ggaccgccta
     3481 tcaggagagt gatttgactg gatttgtaag cttatcctat tcgagtgaag attgtgcaga
     3541 gattgattgt ctcggcgtaa aaaagcttat caaggtagaa aaattgggag ccaattgctt
     3601 gctactttag agagtgaagc tcataaaaaa gttggttatc tgcaggtcaa aacagtggca
     3661 gaaggttcta ataaagatta tgatcgaaca aatgactttt atcgaggtct tggctttaaa
     3721 aagttagaga tttttcttca actatggaat ccgcaaaatc cttgtcagat tttgattaaa
     3781 aagcttgaat aatattactt gacatctatt ctcagagtgc tatactgtaa gtgtaatcgc
     3841 cgatttagct tagttggtag agcaaggcac tcgtaaagcc taggttatag gtagataaac
     3901 gactgaggat ttgaaaaaat agataggtag aagataaccg ttaagcctta ctcttagcgg
     3961 ttatttatat tgtttaatag cgctgatatt tcatcaatta tgcctgtttt cgtgtttctg
     4021 gtagttgttc aagtttattg ctactatttt tgatggtatg aatgtgctta taatgtatcc
     4081 cggttaacga aagttttgga cttatactct tcgaaaatct cttcaaacca cgtcaacgtc
     4141 gccttgccgt gcgtatggtt actgacttcg tcagttctat ccacaacctc aaaacagtgt
     4201 tttgagctga ctacgtcagt tccatctaca acctcaaaac agtgttttga gcaacctgcg
     4261 gctagtttcc tagtttactc tttgattttc attgagtact aatcttattt tttaacgtgt
     4321 gctaaaaaat aaattaatgc atgttaattt ttcttgaatt aaattttttt aaatgatata
     4381 ctgtttttat ggagagataa caattatata taaatgtact actctatttc ctagataata
     4441 cttagtaaaa ctttttataa caaaggctag caaagttaaa gtttattatc tattggaagt
     4501 taaataaata tgtaaggaat taaaatgaaa aaaagtacag tattgtcatt aaccacagct
     4561 gcagttattt tagcagccta tgcccctaat gaggtagtct tagcagacac atctaactct
     4621 gaagatgctt taaacatctc tgataaagaa aaagtagtat tagataagga aacagaaaat
     4681 aaagagaaac atgaagatat tcataatgct atagaaactt cacaggattt taaagagaag
     4741 aaaacagcag tcattgaggg aaaagcagtt gttagtaaaa atcctgtgac agacaataac
     4801 actagcaatg aagaagcaag aatcaaagaa gattccaatc aatcccaagg agatcatacg
     4861 gactcatttg tgaataaaaa cacagaaaat cccaaaaaag aagataaagt tgtctatatt
     4921 gctgaattta aagataaaga atctggagaa aaagcaatca agcaactatc caatcttaag
     4981 aatacaaaag ttttatatac ttatgataga atttttaacg gtagtgccat agaaacaact
     5041 ccagataact tggacaaaat taaacaaata gaaggtatta catcggttga aagggcacaa
     5101 aaagtccaac ccatgatgaa tcatgccaga aaggaaattg gagttgagga agctattgat
     5161 tacctaaagt ctatcaatgc tccgtttggg aaaaattttg atggtagagg tatggtcatt
     5221 tcaaatatcg atactggaac agattataga cataaggcta tgagaatcga tgatgatgcc
     5281 aaagcctcaa tgagatttaa aaaagaagac ttaaaaggaa ctgataaaaa ttattggttg
     5341 agtgataaaa tccctcatgc gttcaattat tataatggtg gcaaaatcac tgtagaaaaa
     5401 tatgatgatg gaagggatta ttttgaccca catgggatgc atattgcagg gattcttgct
     5461 ggaaatgata ctgaacaaga tatcaaaaac tttaacggca tagatggaat tgcacctaat
     5521 gcacaaattt tctcttacaa aatgtattct gacgcaggat ctgggtttgc gggtgatgaa
     5581 acaatgtttc atgctattga agattctatc aaacacaacg ttgatgttgt ttcggtatca
     5641 tctggtttta caggaacagg tcttgtaggt gagaaatatt ggcaagctat tagggcatta
     5701 agaaaagcag gcattccaat ggttgtcgct acgggtaact atgcgacttc tgcttcaagt
     5761 tcttcatggg atttagtagc aaataatcat ctgaaaatga ccgacactgg aaatgtaaca
     5821 cgaactgcag cacatgagga tgcgatagcg gtcgcttctg ctaaaaatca aacagttgag
     5881 tttgataaag ttaacatagg tggagaaagt tttaaataca gaaatatagg ggcctttttc
     5941 gataagaata aaatcacaac aaatgaagat ggaacaaaag ctcctagtaa attaaaattt
     6001 gtatatatag gcaaggggca agaccaagat ttgataggtt tggatcttag gggcaaaatt
     6061 gcagtaatgg atagaattta tacaaaggat ttaaaaaatg cttttaaaaa agctatggat
     6121 aagggtgcac gcgccattat ggttgtaaat actgtaaatt actacaatag agataattgg
     6181 acagagcttc cagctatggg atatgaagcg gatgaaggta ctaaaagtca agtgttttca
     6241 atttcaggag atgatggtgt aaagctatgg aacatgatta atcctgataa aaaaactgaa
     6301 gtcaaaagaa ataataaaga agattttaaa gataaattgg agcaatacta tccaattgat
     6361 atggaaagtt ttaattccaa caaaccgaat gtaggtgacg aaaaagagat tgactttaag
     6421 tttgcacctg acacagacaa agaactctat aaagaagata tcatcgttcc agcaggatcc
     6481 acatcttggg ggccaagaat agatttactt ttaaaacccg atgtttcagc acctggtaaa
     6541 aatattaaat ctacgcttaa tgttattaat ggcaaatcaa cttatggcta tatgtcagga
     6601 actagtatgg cgactccaat cgtggcagct tctactgttt tgattagacc gaaattaaag
     6661 gaaatgcttg aaagacctgt attgaaaaat cttaagggag atgacaaaat agatcttaca
     6721 agtcttacaa aaattgccct acaaaatact gctcgaccta tgatggatgc aacttcttgg
     6781 aaagaaaaaa gtcaatactt tgcatcacct agacaacagg gagcaggcct aattaatgtg
     6841 gccaatgctt tgagaaatga agttgtagca actttcaaaa acactgattc taaaggtttg
     6901 gtaaattcat atggttccat ttctcttaaa gaaataaaag gtgataaaaa atactttaca
     6961 attaagcttc acaatacatc caacaggcct ttaaccttta aagtttcagc atcagcggta
     7021 actacagatt ctctaactga cagactaaaa ctggatgaaa catataaaga tgaaaaatct
     7081 ccagatggta agcaaattgt tccagaaatt catccagaaa aagtcaaagg ggcaaatatt
     7141 acatttgagc atgacacttt cactataggg gcaaattcta gctttgattt aaatgcggtt
     7201 ataaatgttg gggaggctaa aaataaaaat aaatttgtag aatcatttat tcattttgag
     7261 tcagtagaag aaatggaagc attaagctcc aatggcaaga aaaccgactt ccaaccatct
     7321 ttatcaatgc ccctaatggg atttgctggg aattggaacc acgaaccaat ccttgataaa
     7381 tgggcttggg aagaaggatc aaaatcaaaa acaatggaag gttatgatga tgacggtaaa
     7441 ccaaaaattc caggaacctt aaataagggg attggtggag aacatggtat agataaattt
     7501 aatccagcag gagttatcca aaatagaaaa gataaaaata gaacatctct agatcaagat
     7561 ccagacttat ttgcctttaa caaccaaggt gttcatgcag aatccactag tggttctaag
     7621 attgctaaca tttatccttt agattcaaat ggaaatcctc aagatgctca actagaaaga
     7681 ggactaactc catctccact tgttctaaga agtgcagaag aaggactaat ttcaattgta
     7741 aacaccaaca aagaaggaga aaaccaaaaa gaccttaaag ttgtatcaag agagcacttc
     7801 ataagaggaa ttctaaattc taagggaaat gacgctaagg gtatcaaatc atccaaacta
     7861 aaagtttggg gtgacttgaa atgggatgga ctcatctata acccaagagg tagagaagaa
     7921 aatgccccag aaagtaagga taaccaagat ccagctacta agatacgagg acaatttgaa
     7981 ccgattgcgg aaggtcaata tttctataaa tttaaatata gattaactaa agattaccca
     8041 tggcaggttt cctatattcc tgtaaaaatt gataacacag cccctaagat tgtttcggtt
     8101 gatttttcaa atcctgaaaa aattaagcta atcacaaagg atacttatca caaggtaaaa
     8161 gatcaataca agaatgaaac tttatttgct agagatcaaa aagaacatcc tgaaaaattt
     8221 gatgagattg caaatgaggt gtggtatgca ggagctgctc ttgttaatga agatggagag
     8281 gttgagaaaa atcttgaagt aacttatgca ggtgagggtc aaggaagaaa taggaagctt
     8341 gataaagatg ggaatactat ctatgaaatt agcggagcag gagatctaag aggaaaaatc
     8401 atcgaagtaa tcgccctaga tggagcaagc aactttacca aaatccatag gattaaattt
     8461 gctaatcaag ctgatgaaaa agggatgatt tcctattatc tagtagatcc tgatcaggat
     8521 tcatctaaat accaaaagct tggcgaaatt cctgaatcta aatttaagaa tttaaaaaat
     8581 gttaaagatg atagcctaaa caaagagaca gctgaggtgg aaaataacct tttagtagat
     8641 aatcagtcta tcgaaggaaa atctctcttt aatattcata aaactatttc aacaattaga
     8701 gactttgaaa ataaagacct aaagaaactc attaaaaaga aatataagca agaagacgac
     8761 tttgtaaatg gtggaacaag aacagtagag cgtgattata aatacgatga taaaggaaat
     8821 ataatagcct acgatgatgg gactgatcta gaatatgaaa ctgagaaact tgacgaaatc
     8881 aaatcaaaaa tttatggtgt tctaagtccg tctaaagatg gacactttga aattcttgga
     8941 aagataagta atgtttctaa aaatgccaag gtatattatg ggaataacta taaatctata
     9001 gaaatcaaag cgaccaagta tgatttccac tcaaaaacga tgacatttga tctatacgct
     9061 aatattaatg atat
//
LOCUS       DAVHIZ010000064         8958 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.066, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000064 DAVHIZ010000000
VERSION     DAVHIZ010000064.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8958)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8958)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8958
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.066"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            72..422
                     /locus_tag="VVO18_001768"
     CDS             72..422
                     /locus_tag="VVO18_001768"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811778.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PD-(D/E)XK nuclease family transposase"
                     /protein_id="HEU5586871.1"
                     /translation="MLRHPGISPTNDLIAKKIFSNPEITCQFIRDMLDLPAKNVTILE
                     GSDIHVLLSMPYSVQDFYTSIDVLAELDNGTQVIIEIQVHHQNFFINHLWAYLCSQVN
                     QNLEKIRQREGDTH"
     gene            637..753
                     /locus_tag="VVO18_001769"
     CDS             637..753
                     /locus_tag="VVO18_001769"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000233180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="damage-inducible protein CinA"
                     /protein_id="HEU5586872.1"
                     /translation="MVGVFRQQTLYPATATSHYPSKSTAGLQELVRGGQENV"
     gene            746..979
                     /locus_tag="VVO18_001770"
     CDS             746..979
                     /locus_tag="VVO18_001770"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586873.1"
                     /translation="MFSQLHMREEQVLLAQDYASETARAEGLEQGLERGKVEGRAERK
                     LFAFLDIVRQGLLTSEVASQQLGMSVSEFEALL"
     gene            1108..1389
                     /locus_tag="VVO18_001771"
                     /pseudo
     CDS             1108..1389
                     /locus_tag="VVO18_001771"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
     gene            complement(1523..2491)
                     /locus_tag="VVO18_001772"
     CDS             complement(1523..2491)
                     /locus_tag="VVO18_001772"
                     /EC_number="2.7.6.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006149122.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate diphosphokinase"
                     /protein_id="HEU5586874.1"
                     /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV
                     NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK
                     ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR
                     GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK
                     TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL
                     DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI"
     gene            complement(2636..3451)
                     /locus_tag="VVO18_001773"
     CDS             complement(2636..3451)
                     /locus_tag="VVO18_001773"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000749763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PrsW family intramembrane metalloprotease"
                     /protein_id="HEU5586875.1"
                     /translation="MKKSSILFIFILLLCIGLQYETIYYTDGSRSGAEYGLMGVSIFL
                     ALFYMIPALYFLFRIGKKWELPKKVLILSLLGGMFLSGWLSSFANTYIHDLLGVLFPD
                     STFLNAFESAIVAPLVEEPLKLLPLVFVLALIPVRKLKSLFLLGIASGLGFQMIEDIG
                     YIRTDLPEGFDFTISRILERIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLI
                     FLGLALGTHFLFNSPFVELETELPLAIPVVTAIALYGFYHAYCFVEKHNELMT"
     gene            complement(3476..3973)
                     /locus_tag="VVO18_001774"
     CDS             complement(3476..3973)
                     /locus_tag="VVO18_001774"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007285146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbonic anhydrase"
                     /protein_id="HEU5586876.1"
                     /translation="MSYFEQFMQANQAYVALHGQLNLPLKPKTRVAIVTCMDSRLHVA
                     QALGLALGDAHILRNAGGRVTEDMIRSLVISQQQMGTREIVVLHHTDCGAQTFENEPF
                     QEYLKEELGVDVSDQDFLPFQDIEESVREDMQLLIESPLIPDDVIISGAIYNVDTGSM
                     TVVEL"
     gene            complement(4046..5407)
                     /gene="radA"
                     /locus_tag="VVO18_001775"
     CDS             complement(4046..5407)
                     /gene="radA"
                     /locus_tag="VVO18_001775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000336571.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA repair protein RadA"
                     /protein_id="HEU5586877.1"
                     /translation="MAKKKATFVCQNCGYNSPKYLGRCPNCGSWSSFVEEVEVAEVKN
                     ARVSLTGEKTKPMKLAEVTSINVNRTKTEMEEFNRVLGGGVVPGSLVLIGGDPGIGKS
                     TLLLQVSTQLSQVGTVLYVSGEESAQQIKLRAERLGDIDSEFYLYAETNMQSVRAEVE
                     RIQPDFLIIDSIQTIMSPEISGVQGSVSQVREVTAELMQLAKTNNIAIFIVGHVTKEG
                     TLAGPRMLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEIGIFEMQSGGLVEVLNP
                     SQVFLEERLDGATGSSIVVTMEGTRPILAEVQALVTPTMFGNAKRTTTGLDFNRASLI
                     MAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAIDLAVAVAIASSYKDKPTNPQECFVGE
                     LGLTGEIRRVNRIEQRINETAKLGFTKIYVPQNSLTGITLPKEIQVIGVTTIQEVLKK
                     VFA"
     gene            complement(5421..5936)
                     /locus_tag="VVO18_001776"
     CDS             complement(5421..5936)
                     /locus_tag="VVO18_001776"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691237.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="histidine phosphatase family protein"
                     /protein_id="HEU5586878.1"
                     /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK
                     NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL
                     FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID
                     FCQVIECELEI"
     gene            complement(5938..6381)
                     /locus_tag="VVO18_001777"
     CDS             complement(5938..6381)
                     /locus_tag="VVO18_001777"
                     /EC_number="3.6.1.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000701981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dUTP diphosphatase"
                     /protein_id="HEU5586879.1"
                     /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI
                     VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM
                     KNITDQEVVLEVGERIVQAVFATFLIADGDAADGVRTGGFGSTGH"
     gene            complement(6438..6535)
                     /gene="ffs"
                     /locus_tag="VVO18_001778"
     ncRNA           complement(6438..6535)
                     /ncRNA_class="SRP_RNA"
                     /gene="ffs"
                     /locus_tag="VVO18_001778"
                     /product="signal recognition particle sRNA small type"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00169"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00169"
     gene            complement(6568..7035)
                     /locus_tag="VVO18_001779"
     CDS             complement(6568..7035)
                     /locus_tag="VVO18_001779"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoside deaminase"
                     /protein_id="HEU5586880.1"
                     /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG
                     HNAREELQRAVMHAEIMAIEDANLSKESWRLLDCTLFVTIEPCVMCSGAIGLARIPNV
                     VYGAKNQKFGAAGSLYDILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK"
     gene            complement(7236..8522)
                     /locus_tag="VVO18_001780"
     CDS             complement(7236..8522)
                     /locus_tag="VVO18_001780"
                     /EC_number="6.3.4.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017279.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="adenylosuccinate synthase"
                     /protein_id="HEU5586881.1"
                     /translation="MTSVVVVGTQWGDEGKGKITDFLSANAEVIARYQGGDNAGHTIV
                     IDGKKFKLHLIPSGIFFPEKISVIGNGMVVNPKSLVKELSYLHEEGVTTDNLRISDRA
                     HVILPYHIELDRLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFRERL
                     ERNLAEKNRLFEKLYDSKAIVFDDIFEEYYEYGQQIKKYVIDTSVILNDALDNGKRVL
                     FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKIDKVVGVCKAYTSRVGDGP
                     FPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVL
                     SGLDTVKICVAYDLDGQRIDYYPASLEQLKRCKPIYEELPGWSEDITGVRNLEDLPEN
                     ARNYVRRVSELVGVRISTFSVGPGREQTNILESVWS"
     gene            complement(8753..>8958)
                     /locus_tag="VVO18_001781"
     CDS             complement(8753..>8958)
                     /locus_tag="VVO18_001781"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="recombinase RecX"
                     /protein_id="HEU5586882.1"
                     /translation="FYDSIEEEYGPTFGDNFDWEHVHFKFLIYYLVRYGIGCHRDFIV
                     YHYRVAYRLYLEKLVMNRGFISC"
BASE COUNT         2855 a         2144 c         1511 g         2448 t
ORIGIN      
        1 aattaatttg actttcctga tagagttatt cacatcttat ttcaactcac tatagaagga
       61 ggaataggag gattctcaga catccgggca tcagcccaac taatgatttg attgctaaga
      121 aaatattcag caatccagaa atcacttgtc aatttattcg cgatatgctg gacttgccag
      181 caaaaaatgt gaccattttg gagggaagcg atattcacgt attactctcc atgccttact
      241 cggtgcagga tttttatacc agtatagacg tcttggcgga gttggataac ggtactcaag
      301 taattattga gattcaagtc catcatcaga attttttcat caatcacttg tgggcttacc
      361 tgtgcagtca ggttaatcaa aatcttgaaa aaattcgtca gcgagaaggt gatactcact
      421 agatctacaa acacatcgct cctgtttacg tcattgctat cgtggatagt aattatttct
      481 cagatgacct ggcttttcat agctttagta tgcgcgaaga cacaacaggt gaggtattgg
      541 cgattaccaa caatggacag gaaaaccatc tggttaagat ggcattcttg gaattaaaaa
      601 atacagagaa accagcaaag acaaggttcg caagccatgg ttggagtttt tcggcaacaa
      661 accctttacc cagcaaccgc aacgagccat tacccaagca aatcaactgc tggactacaa
      721 gagctggtcc gaggaggaca ggaaaatgtt tagtcaacta catatgcgag aagaacaagt
      781 cttgttagca caggactatg cctcggaaac tgctagggct gaaggccttg aacaaggact
      841 agagcgtggg aaagttgaag gaagggcaga aaggaaactt tttgccttcc tagacatagt
      901 acgccaaggt cttctgactt ctgaggttgc cagccagcaa ttaggtatgt cagtatctga
      961 atttgaggca ctgttgtaaa atggctccat aatatccata ggggatttac ccactatgga
     1021 tattatggag cctattttgt gtaaaaaaaa aaagtcccat atgacctata atgaaaagcg
     1081 acaaaacaac tcattagaaa gaatcatatg gaacaattac attttatcac aaaattacta
     1141 gacattaaag accctaatgt ccagatttta aacatcatca ataaggatac acacaaggaa
     1201 atcatcgcca aactggacta cgacgcccca tcttgccctg agtgcggaaa ccaattgaag
     1261 aaatatgact ttcaaaaacc ttctaaaatt ccttatcttg aaacgactgg tatacctact
     1321 agaattctcc ttagaaagcg tcgattcaag tgctatcact gttcaaaaat gatggtcgct
     1381 gaaacttctg atgacgtaca gtcatatttc ttttcttttt attatatcac agttttaaat
     1441 ctagctttac tagattcacc gctactatct atttattcgg aaaaaagacg aaaaaacctg
     1501 agaatcatct caggcttggt cattaaattt ttttctcaat atcgaaaagt ggagaaagtg
     1561 gtcgtttttc atgaatacgt acgatagcat cccctaggag atgagcgatt gaaatctgct
     1621 caatcttatc aatcaaacgc tcttctggca gatagatggt atccaaaaca accaatttct
     1681 taatagctga tttttggata ttgtccgtag caggaccaga aagaactggg tgcgtacagc
     1741 ttgcatagac ttcaacagca ccagcttccg caagagcatc tgccgcatga caaatcgttc
     1801 cagcggtatc aatcatatca tcaatcaaga tacaagtctt gccttcaacc ttaccgatga
     1861 tgttcataac ttcactagta ttcatcttat caacgctgcg acgtttatca ataatagcga
     1921 tagatgtttt caaaaattct gccaacttac gagcacgagt cacccctcca tggtccgggc
     1981 tgacaaccac atagtcagaa ccaaccatac cacgacgctc aaaataatct gcaatcagag
     2041 gagcacccat caaatgatcc acaggaatat caaagaatcc ttgaatttgc gcagcatgca
     2101 agtcgatggt caataaacga tccactccag ctacttcaag catatttgcg acaagttttg
     2161 aagtgattgg ctcacgcgct ctcgcctttc tatcctgacg tgcataccca tagtaaggca
     2221 tgacaacatt gacagattct gcactcgcac gcttcaaagc atctaccata atcaaaattt
     2281 caagcagatt gtcatttaca ggcgaactag ttgattgtag gataaagacg tgtttcccac
     2341 ggattgattc ttcaatgttg acctgaatct ctccatctga aaattggcga acacttgatt
     2401 tccccaactc tatcccaatc tcctgcgcca cacgttctgc caattcttta ttagaagaaa
     2461 gggcaaacag ctttaaatca gaaaaagaca tgatttcctc cggtatatat gtataacttg
     2521 tgcctttcac aagattttcc atctaccatt gtagcgcttt ttgcactatt tttcaatcaa
     2581 aaataaaaga agggcaccat atttgtaccc ttgcatcatt cttttgaaaa atattctagg
     2641 tcatcaactc attgtgtttc tcaacaaagc aataagcatg ataaaaacca tagagagcaa
     2701 tagccgtaac cactggaatc gctaaaggca actctgtttc caactccaca aaaggagagt
     2761 taaacaagaa gtgagttccc aaggctaaac ctagaaaaat aaggccctgt ttcttgccaa
     2821 ccttctgtcc tttataggct ctgtaaagca agtaaacacc tactacagct agacctgaaa
     2881 aagtccagtg agaggcaatt cctgagatga tacgctctaa aattcgcgaa atagtaaagt
     2941 caaagccctc tggcaaatcc gtacgaatat aaccaatatc ctcaatcatt tggaatccca
     3001 aaccggaagc aattccaagt aaaaacaaag attttaattt tcgcacagga atcaaagcca
     3061 aaacaaaaac aagtggcaat aatttcaagg gttcttctac caaaggagcc acaatagcac
     3121 tttcaaaggc atttaaaaat gtactatctg ggaaaagaac ccccagtaaa tcatggatat
     3181 aagtattagc aaaactagac aaccagcctg aaaggaacat ccctcccaat aaagacagaa
     3241 tcaaaacctt ctttggcaat tcccattttt tcccaatacg gaagagaaaa taaagagccg
     3301 gaatcatgta aaagagagct agaaagatag aaactcccat tagtccatat tccgcacctg
     3361 acctcgaacc gtccgtatag tagatggttt catactgtaa accaatacat agcaataaaa
     3421 taaaaataaa taaaatactg ctcttcttca tacactttct ttctaaatga agtatttata
     3481 attctacgac tgtcatactt cctgtatcaa cattgtaaat agcaccagag ataatgacat
     3541 cgtctggtat taggggagac tcgataagca gttgcatatc ctcgcgtaca ctctcttcta
     3601 tatcttggaa gggcaagaag tcctggtctg acacatctac acctaattcc tcttttaaat
     3661 actcctgaaa aggttcattt tcaaaggtct gagcaccaca gtctgtatgg tgcaatacca
     3721 caatctctct tgtccccatt tgttgctggg aaataactag cgaacgaatc atgtcttcag
     3781 tcactcgacc acctgcattc cgcaaaatat gagcatcccc aagtgccaag cccagagctt
     3841 gcgcaacgtg caaacgtgag tccatacagg tcacaatggc tactctggtt ttaggtttaa
     3901 gtggcagatt taactgccca tgtagggcaa cataagcctg attggcttgc ataaactgtt
     3961 caaaatacga cacgattccc tccttgaaaa tttgatagtc aaatatttct cctatcttat
     4021 catttttaag agaatttgtc acggattatg caaagacctt tttcaaaact tcctgaatcg
     4081 ttgtcacgcc aatgacctga atttccttag gcagagtgat tcctgtcaag gaattctgag
     4141 gtacataaat cttagtaaag cccagtttag cagtttcgtt gatgcgttgc tcaatacgat
     4201 tcacgcgccg aatctctcct gtcaagccca gttctccgac aaaacattcc tgaggattag
     4261 ttggcttgtc tttgtagctc gaagcaatag caactgcaac agccaagtca atggcaggtt
     4321 catccaattt aacaccacca gcagatttga gataggcatc ctgattttgc aagagaagcc
     4381 ctgcccgttt ttccaaaaca gccataatca agctagcacg gttaaaatca agtcctgtcg
     4441 tagtacgctt ggcatttcca aacatggtcg gtgttaccaa agcctgaacc tccgccaaaa
     4501 tcggacgcgt cccttccatg gttacaacga tggaggaacc agtcgcccca tccaaacgct
     4561 cttctaggaa aacttgactc ggattgagta cctcaaccaa gccgcccgac tgcatctcaa
     4621 aaatcccaat ctcattagtg gaaccaaaac gatttttgac cgctctcaaa atacgaaagg
     4681 tgtggtgacg ctccccttca aagtaaagca ccgtatccac catatgctcc aacatacgag
     4741 gcccagccaa ggttccttct ttggtcacat gacctacgat aaagatggca atgttattgg
     4801 tcttggccaa ctgcatgagt tcagcggtca cttcacgtac ctgagaaaca gacccctgca
     4861 cccctgaaat ctcaggagac atgatggtct ggatggaatc aataatgaga aagtctggct
     4921 ggatacgctc cacttctgca cgaacactct gcatattggt ctctgcatag agataaaact
     4981 cactatcaat atcacctaag cgctctgcac gtagtttaat ctgctgggca gactcctccc
     5041 cactgacata gagaactgtc cccacttggg acaactgggt tgagacttgt aggagaagag
     5101 ttgatttccc aatcccagga tccccaccga tgaggacgag acttcctggt accactccgc
     5161 ctccaagcac acggttgaat tcctccatct ccgtcttggt tcgattgaca ttgatggaag
     5221 tcacctcagc tagtttcatg ggcttggttt tctcacctgt caaggacaca cgcgcattct
     5281 tgacctcggc aacctcaacc tcttccacaa aagaagacca agacccacag ttggggcaac
     5341 gtcccagata tttaggggaa ttatacccac aattttgaca tacaaatgtc gcttttttct
     5401 ttgcgatgac aaacctcttt ctatatctct aactcacact caatcacttg gcaaaaatca
     5461 atcttctcat ttggcacaaa ctggcgcatg agcattcgat gagcaacaac taccacagtc
     5521 tgatgttctc gatacttaga catacattct agaaaccgag acttcatttc cgtagctgtc
     5581 tcatattgaa taggactatt aggaagcaac tcccccttgt tttctaaaaa cagtcttcta
     5641 gctgtttcaa agttttctat tcctgtttta tagacctgcc attcatgtaa taaaggctct
     5701 actcttaaag gaagacccgt agcacagacc acatacgaag ccgtttctaa agctcttgtg
     5761 actgcagaag atacgattat ttcagctgac gagagtaaag gatttttgct caatttctgg
     5821 acttgctgcc gtcccatctc agacaagggt gccaaatcta tcccaaatcc tatataagaa
     5881 cgctcctcta actcacggta atctggctcc ccatgacgta caaagataat cttcattcta
     5941 gtgccctgtc gatccaaatc caccagttcg aacgccatca gctgcatctc catctgcaat
     6001 taagaaagta gcaaaaacag cctggacaat acgttcccca acttcaagaa caacctcttg
     6061 gtctgtgata ttcttcatct gcgcaaaaat atgcccttca tttccaggat ttccataata
     6121 atccccatca atgaccccaa ctgagttaat taaaaccaag cccttcttac gaggatttga
     6181 agaacgatca tagaggtaga gaacctcagt cggctgcata taagccttaa cccctgtcgg
     6241 aaccaagaca atctctcctg gcgcaacaac tgtacgcaca gcaaccttta agtcgtaacc
     6301 agccgcatgc gctgtctcac gcttgggcaa taaattttca tctgtaaaac tcgaaaccaa
     6361 ttcaaaacca cgaattttca taattttctc ttttctatta tcatttattc tagattattc
     6421 tatcttattt attcggaaaa agcacgaaaa aaagagcaca caattcaaat cgcttagggc
     6481 tgctggattc ctcccctgac ccgcttcacg cagaactgtt gctccactat ttattatatc
     6541 acattcctat tcattttaaa agcaaaatta ttttttccgt ctatttctaa aaaaatcctg
     6601 catgatagct gcgcattcat cttccaaaat tcctatttca acctccacac gatgattgag
     6661 acgctcatct gtcaagatat cgtacaaact cccagcagcg ccaaatttct ggtttttagc
     6721 cccatagacc acatttggaa tgcgggcaag cccaatcgcc ccactacaca tgacacaagg
     6781 ttcaatggtc acaaaaagtg tgcaatccag caagcgccag ctctccttac tcaagttcgc
     6841 atcctctata gccataattt ccgcatgcat aaccgctcgc tgtaattcct cacgcgcatt
     6901 atgcccacga ccaatgattt ccccatcttt gacaatcaca caaccaattg gaatttcatc
     6961 gtgttcaaga gcaatctcag cctctctcaa agcctccctc ataaagactt ctttttcttc
     7021 aagcgtataa tacatctctt ttctcttttc ctacttatcg attttattat tatatcatga
     7081 atcccaacac aaaagaagcc accgaatgcg gtgactctat agggagatta ttatgaaaaa
     7141 gaaaagttta ggatatttgt tacaacaagt taggaggtct tcttgtaacc gtctatagta
     7201 tacccgacct atcttaaaca aatcttaaaa atctcttagg accaaacact ttctaaaata
     7261 tttgtttgtt cacgaccagg acctactgag aaagtagaaa tacgaacgcc aaccaattca
     7321 ctcacacgac gaacatagtt acgcgcattc tcaggaagat cttccaaatt gcgaactccg
     7381 gtaatatctt ctgaccaacc tggcaactct tcatagatag gcttgcaacg tttcaattgc
     7441 tcaagactag ctggatagta gtcaatacgt tgaccgtcaa gatcataggc cacacagatt
     7501 ttcacagtat ccaaaccgct caaaacatca atagagttca aagaaaggtt agtaatacca
     7561 gaaacacgac ggctatgacg catcacaact gagtcaaacc aacctacacg acgtggacga
     7621 ccagttgttg taccatactc atgacccact tcacggatac gttctcccac ttcatcaaac
     7681 aactcagttg ggaaaggacc atctcctaca cgactcgtat aagctttaca tacacctaca
     7741 accttgtcaa tcttgcttgg accgacacca gaaccaattg tcacaccacc agctacaggg
     7801 tttgatgacg taacaaatgg ataagtacct tggtcgatat ctagcataac accttgtgca
     7861 ccttcaaaaa gcacacgttt gccattatca agcgcatcat tcaagataac agatgtatct
     7921 atcacgtatt tcttgatttg ttgaccatat tcgtaatatt cttcaaaaat atcatcgaaa
     7981 acaatcgctt tactgtcata caatttttca aaaagacgat tcttttcagc aaggttacgt
     8041 tctaaacgct cacggaaaat atctttatct aaaagatctg caatacgaat tccaacacga
     8101 gcagccttgt ccatataagc tggaccaatt cccttaattg tcgtaccaat cttattgtcg
     8161 cccttagctt cttcttgcaa gcgatccaac tcgatatgat aaggcaaaat aacatgcgca
     8221 cgatcagaaa tacgcaagtt atcagttgtt acaccttcct catgaagata gctcaactct
     8281 tttacaagag atttaggatt tacaaccata ccattcccaa tgacagatat tttttcaggg
     8341 aagaaaatcc cagatggaat caagtgcaac ttaaatttct taccgtcaat cacaatcgtg
     8401 tgaccagcat tatcaccacc ttggtaacgt gcaatcactt ctgcattcgc tgaaaggaag
     8461 tctgtaatct tccctttacc ttcatcaccc cattgggtac ctacaacaac aactgaagtc
     8521 ataattttgt ctgagccctc aggctcttcc tttctcacat acatggcagg actctcacct
     8581 gcaattatat cttacaattt attataataa aaaatcgcct ttttatcaag aagaaacaat
     8641 agaaagattt gctatttcca actattaaaa aatgatttag aaaaattact agctatttac
     8701 tattatcttt ccataaaaga gtaaattagt tcggaaattt actaaaatta cctcaacaag
     8761 aaataaaacc ccgattcatt accaattttt caagatacaa acgataagca acacgataat
     8821 ggtaaacgat aaaatcccta tgacaaccaa tgccatatct cactaaataa taaattaaaa
     8881 atttaaaatg aacatgttcc cagtcaaaat tatcaccaaa tgtaggacca tactcttctt
     8941 caatactatc atagaaat
//
LOCUS       DAVHIZ010000065         8958 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.067, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000065 DAVHIZ010000000
VERSION     DAVHIZ010000065.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8958)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8958)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8958
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.067"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(296..1144)
                     /gene="dprA"
                     /locus_tag="VVO18_001782"
     CDS             complement(296..1144)
                     /gene="dprA"
                     /locus_tag="VVO18_001782"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-protecting protein DprA"
                     /protein_id="HEU5586883.1"
                     /translation="MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADIS
                     GCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDCYPWDLSEIYDAPVLLFYKGNLD
                     LLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
                     TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRG
                     VIVAEAKMRSGSLITCERAMEEGRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDV
                     LAEFEF"
     gene            complement(1250..1939)
                     /locus_tag="VVO18_001783"
     CDS             complement(1250..1939)
                     /locus_tag="VVO18_001783"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399459.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NTP transferase domain-containing protein"
                     /protein_id="HEU5586884.1"
                     /translation="MKAIILAAGLGTRLRPMTENTPKALVQVNQKPLIEYQIEFLKEK
                     GINDIIIIVGYLKEQFDYLKEKYGVRLVFNDKYADYNNFYSLYLVKEELANSYVIDAD
                     NYLFKNMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFW
                     DAPTAEKIVSFIDKAYASGEFVDLYWDNMVKDNIKELDVYVEELEGNSIYEIDSVQDY
                     RKLEEILKNEN"
     gene            complement(1951..2829)
                     /locus_tag="VVO18_001784"
     CDS             complement(1951..2829)
                     /locus_tag="VVO18_001784"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000837620.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DMT family transporter"
                     /protein_id="HEU5586885.1"
                     /translation="MKSKNGVPFGLLSGIFWGLGLTVSAYIFSIFTDLSPFVVAATHD
                     FLSIFILLAFLLVKEGKVRLSIFLNIRNVSVIIGALLAGPIGMQANLYAVKYIGSSLA
                     SSVSAIYPAISVLLAFFFLKHKISKNTVFGIVLIIGGIIAQTYKVEQVNSFYIGILCA
                     LVCAIAWGSESVLSSFAMESELSEIEALLIRQVTSFLSYLVIVLFSHQSFTAVANGQL
                     LGLMIVFAAFDMISYLAYYIAINRLQPAKATGLNVSYVVWTVLFAVVFLGAPLDMLTI
                     MTSLVVIAGVYIIIKE"
     gene            complement(2819..3688)
                     /gene="licA"
                     /locus_tag="VVO18_001785"
     CDS             complement(2819..3688)
                     /gene="licA"
                     /locus_tag="VVO18_001785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000411210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="choline kinase LicA"
                     /protein_id="HEU5586886.1"
                     /translation="MEKIIKEKISSLLSQEEEVLSVEQLGGMTNQNYLAKTTNKQYIV
                     KFFGKGTEKLINRQDEKYNLELLKDLGLDVKNYLFDIEAGIKVNEYIESAITLDSTSI
                     KTKFDKITPILQTIHTSAKELRGEFAPFEEIKKYESLIEEQIPYANYESVRNAVFSLE
                     KRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDWEYSSMNDPMWDLAALFLESEFTS
                     QEEETFLSHYESDQTPVSHEKIAIYKILQDTIWSLWTVYKEEQGEDFGDYGVNRYQRA
                     IKGLASYGGSDEK"
     gene            complement(3705..4727)
                     /locus_tag="VVO18_001786"
     CDS             complement(3705..4727)
                     /locus_tag="VVO18_001786"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004257983.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alcohol dehydrogenase catalytic
                     domain-containing protein"
                     /protein_id="HEU5586887.1"
                     /translation="MINQIYQLTKPKFINVKYQEEAIDQENHILIRPNYMAVCHADQR
                     YYQGKRDPKILNKKLPMAMIHESCGTVISDPTGTYEVGQKVVMIPNQSPMQSDEEFYE
                     NYMTGTHFLSSGFDGFMREFVSLPKDRVVAYDAIEDTVAAITEFVSVGMHAMNRLLTL
                     AHSKRERIAVIGDGSLAFVVANIINYTLPEAEIVVIGRHWEKLELFSFAKECYITDNI
                     PEDLAFDHAFECCGGDGTGPAINDLIRYIRPQGTILMMGVSEYKVNLNTRDALEKGLI
                     LVGSSRSGRIDFENAIQMMEVKKFANRLKNILYLEEPVREIKDIHRVFATDLNTAFKT
                     VFKWEV"
     gene            complement(4732..5439)
                     /locus_tag="VVO18_001787"
     CDS             complement(4732..5439)
                     /locus_tag="VVO18_001787"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465903.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase"
                     /protein_id="HEU5586888.1"
                     /translation="MIYAGILAGGTGTRMGISNLPKQFLELGDRPILIHTIEKFVLEP
                     SIEKIVVGVHGDWVSHAEDLVDKYLPLYKERIIITKGGADRNTSIKKIIEAIDAYRPL
                     TPEDIVVTHDSVRPFITLRMIQDNIQLAQNHDAVDTVVEAVDTIVESTNGQFITDIPN
                     RAHLYQGQTPQTFRCKDFMDLYGSLSDEEKEILTDACKIFVIKGKDVALAKGEYSNLK
                     ITTVTDLKIAKSMIEKD"
     gene            5775..7262
                     /gene="tacF"
                     /locus_tag="VVO18_001788"
     CDS             5775..7262
                     /gene="tacF"
                     /locus_tag="VVO18_001788"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835918.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV teichoic acid flippase TacF"
                     /protein_id="HEU5586889.1"
                     /translation="MKSIKLNALSYMGIRVLNIIFPILTGTYVARVLDRTDYGYFNSV
                     DTILSFFLPFATYGVYNYGLRAISNVKDNKKDLNRTFSSLFYLCIACTILTTAVYILA
                     YPLFFTDNPIVKKVYLVMGIQLIAQIFSIEWVNEALENYSFLFYKTAFIRILMLVSIF
                     LFVKNEHDIVVYTLVMSLSTLINYLISYFWIKRDIKLVKIHLSDFKPLFLPLTAMLVF
                     ANANMLFTFLDRLFLVKTGIDVNVSYYTIAQRIVTVIAGVVTGAIGVSVPRLSYYLGK
                     GDKEAYVSLVNRGSRIFNFFIIPLSFGLMVLGPNAILLYGSEKYIGGGILTSLFAFRT
                     IILALDTILGSQILFTNGYEKRITVYTVFAGLLNLGLNSLLFFNHIVAPEYYLLTTML
                     SETSLLVFYIIFIHRKQLIHLGHIFSYTVRYSLFSLSFVAIYFLINFMYPVDMVINLP
                     FLINTGLIVLLSAISYISLLVFTKDSIFYEFLNHVLALKNKFKKS"
     gene            7272..8075
                     /locus_tag="VVO18_001789"
     CDS             7272..8075
                     /locus_tag="VVO18_001789"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004259727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU5586890.1"
                     /translation="MKQLTVEDAKQIELEILDYIDTLCKKHNINYIINYGTLIGAVRH
                     EGFIPWDDDIDLSMPREDYQRFINIFQKEKSKYKLLSLETDKNYFNNFIKITDSTTKI
                     IDTRNTKTYESGIFIDIFPIDRFDDPKVIDTCYKLESFKLLSFSKHKNIVYKDSLLKD
                     WIRTAFWLLLRPVSPRYFANKIEKEIQKYSRENGQYMAFIPSKFKEKEVFPSGTFDKT
                     IDLPFENLSLPAPEKFDTILTQFYGDYMTLPPEEKRFYSHEFHAYKLED"
     gene            8077..8886
                     /locus_tag="VVO18_001790"
     CDS             8077..8886
                     /locus_tag="VVO18_001790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphorylcholine transferase LicD"
                     /protein_id="HEU5586891.1"
                     /translation="MQYLEKKEIKEIQLALLDYIDETCKKHDIPYFLSYGTMLGAIRH
                     KGMIPWDDDIDISLYREDYERLLKIIEEENHHRYKVLSYDTSSWYFHNFASILDTSTV
                     IEDHVKYKRHDTSLFIDVFPIDRFTDLSIVDKSYKYVALRQLAYIKKSRAVHGDSKLK
                     DFLRLCSWYALRFVNPRYFYKKIDQLVKNAVTNTPQYEGGVGIGKEGMKEIFPVDTFK
                     ELILTEFEGRMLPVPKKYDQFLTQMYGDYMTPPSKEMQEWYSHSIKAYRKN"
BASE COUNT         2815 a         1806 c         1510 g         2827 t
ORIGIN      
        1 tcactatact ttcccttata ctcaatgaaa atcaaagcac tgctttgagg ttgtagataa
       61 gactgacgaa gtcagctcaa aatactgttt tgaggttgca gatggaagct gacgtagttt
      121 gaagagattt tcgaagagta ttatatgaga aaaatcctct actctactaa tccacttaga
      181 aaaaacgcat attatcaagt gttaaaaact tgctaatatg cgttttatta tggaaatgtt
      241 gggttcattt tctcttaaaa ttgatttttt cttagaattc tagcttaggt catttttaaa
      301 attcaaattc cgcaagaaca tcttgcccac tggtgaccaa ttttgctcct tcttgaatca
      361 aatgatggca accgtctgat agtccatcta aaatgctacc aggaatagca aagacatcgc
      421 gtccttcttc cattgctcgc tcacacgtaa tgagactacc tgaacgcatc ttagcctctg
      481 ctacaatcac accacgacaa agtccagcaa tgatgcgatt acgggcagga aaatgaaatt
      541 tcagaggttg ttcgccaggt ccatattcac ttagaaccag atggtcattg ccgatgtagt
      601 cttgcaagcg tttattggct ttaggataaa acacatccag tcctgttcca atcactgcaa
      661 tggtttttcc gccattctga agagctgcca tatgagctgc tgtgtcaatg cccttggcca
      721 gaccactgac aataaccagt tcattttcca agccttgaat gactttttca actgacttag
      781 ctccctgttt gctacaagca cgactgccca cgaccgctac cttcgggaat ttcaggaggt
      841 caagatttcc cttgtaaaat aaaagtacag gcgcatcata tatttcactc aaatcccaag
      901 gataacagtc atctaaaata gagaaagatg gaaatttttg aaactctttc gacaaatgcg
      961 catcgtctat ctgaaaataa cgttccataa aaacggctgg attacggcaa cctgatatat
     1021 ctgcaatatc acccaacaaa agctcctgat caacattttc accgtattct agcactttca
     1081 aaatctgttg attggtcaaa cctgattttt ttaacttata gatttcatag tttgtgattt
     1141 tcataaataa ctccatttct ttttctactc atctatctat tcgtaaaagt tcgtaaaagt
     1201 tcgtaaaaaa tcaaaaaaca tccgactatt ttgccagatg ttggaatctt taattttcgt
     1261 ttttaagaat ttcttctaat ttacgatagt cttggacact atcgatctca taaatgctat
     1321 tgccttctaa ttcttcaaca tagacatcta gctctttgat attatcctta accatattgt
     1381 cccaatagag atcaacaaat tcaccacttg cataagcctt gtcgataaag ctgacaatct
     1441 tttctgcagt tggagcatcc cagaaggata caccactaag gatgcgacct gccttgctat
     1501 caacaataat gtcttgaacc ttgtagtcat ctccatagac caagaaccat tcgttggtac
     1561 aatcttcacg ataaacacta aaataagtcg aacgtgtcaa atcattgcgg aacatatttt
     1621 taaagagata attgtcagca tcaataacat agctgttggc caattcttct tttacaagat
     1681 agagagagta aaagttattg tagtcagcgt atttatcatt gaaaacgagg cgaacaccgt
     1741 atttttcttt taagtaatcg aattgttctt taagataacc aacaatgatg atgatgtcat
     1801 tgattccttt ttctttgaga aactcaattt ggtattcaat caaaggtttt tgattaacct
     1861 gaaccaaggc tttaggggta ttttcagtca taggacgcaa gcgagttccc aatcccgctg
     1921 ctaagataat ggctttcaca cgaatctcct ttattcttta ataataatat aaactccagc
     1981 aatgacgaca agtgacgtca taatggtcag catatctagc ggtgcaccca aaaaaacaac
     2041 tgcaaacaag acagtccata ctacatagct cacgttcaag cctgtagcct tggctggttg
     2101 caagcgattg atagcgatat aataagccaa gtaggaaatc atatcaaagg ctgcaaaaac
     2161 aatcatgaga cctagcaatt gtccattggc tactgcagta aatgactgat gagagaagag
     2221 cacaatcaca agataggaca agaacgaagt cacttgacgg attaagaggg cttcgatttc
     2281 actcagttca ctttccatag caaaggagct aagaacactc tcacttcccc atgcaatagc
     2341 acaaaccaaa gcacagagaa tcccaatgta gaaggaatta acctgttcaa ccttataggt
     2401 ctgggcaata atccctccaa taatcaagac aatcccaaat acagtatttt tcgaaatctt
     2461 gtgcttcaaa aagaagaaag ccaatagaac tgaaatcgca gggtaaatag ccgatacaga
     2521 tgaagctaaa gaacttccga tatacttaac tgcataaaga ttggcctgca taccgatagg
     2581 gcctgctagc aaggctccta tgataacact gacattgcga atatttaaga aaattgagag
     2641 gcgaactttc ccttctttta ccaagagaaa agctagtaag ataaagatgc tcaaaaaatc
     2701 atgagttgca gccaccacaa agggtgacaa atctgtaaaa atcgaaaaga tataagcact
     2761 aaccgttaga cccaagcccc agaaaatacc tgagagaagg ccaaaaggaa ctccgttttt
     2821 acttttcatc tgaacctcca taagaagcca aacctttaat agctctttgg taacgattca
     2881 caccatagtc accaaaatct tcaccttgct cttccttata gacagtccat agactccaaa
     2941 tagtatcttg taaaatttta taaatagcaa tcttttcatg agaaaccggt gtttggtcac
     3001 tctcatagtg agataagaaa gtttcttcct cttgggaagt gaattcagac tctaaaaaga
     3061 gggcagccaa atcccacatt ggatcattca ttgatgaata ttcccagtca atcaaataaa
     3121 gtcgtccttg aggtgattcg ataaagtttt caggcaccaa atcgatatga caagattttc
     3181 tgtcaacacc taagtcagcc agtcttttct ctaaggagaa gactgcattt ctaacagatt
     3241 catagttggc ataaggaatt tgttcttcaa tcaaggattc gtattttttg atttcttcaa
     3301 aaggagcaaa ttctcctctt aattccttag cagacgtatg aatagtttgt aatattggag
     3361 taattttgtc gaacttggtc ttgattgacg ttgaatcaag cgtaatcgca gattcgatat
     3421 actcatttac tttgatacca gcttcaatat caaaaagata attttttaca tctaagccta
     3481 aatcctttag tagttcaaga ttgtactttt catcttgtcg attgataagc ttttctgtcc
     3541 ctttaccaaa gaatttaaca atgtattgct tatttgttgt tttggccaaa tagttttgat
     3601 tggtcattcc acccagttgt tcaacactga ggacttcctc ttcttgacta agtaaggaag
     3661 aaattttttc tttaatgatt ttctccacaa ttaacctcca gtacttatac ttcccactta
     3721 aacactgttt taaaggctgt gtttaaatcg gttgcaaaga cacgatgaat atctttaatt
     3781 tctcttacag gttcttctag ataaaggata tttttaagac gattggcaaa tttcttgact
     3841 tccatcattt ggatagcatt ttcaaaatca atgcgaccag aacgagatga cccaaccaaa
     3901 atcaagccct tttctaaggc atcgcgagta ttgagattga ctttatattc gctaactccc
     3961 atcatgagaa tcgttccctg aggacgaatg tagcgaatca agtcattaat agctggtcca
     4021 gtaccatcac caccacaaca ttcaaaagca tggtcaaagg ccaaatcttc aggaatatta
     4081 tccgtaatat agcattcttt ggcaaatgag aagagttcca acttttccca atgacgacca
     4141 ataaccacaa tctctgcttc tggcaaagta tagttgataa tattggcaac cacaaaagct
     4201 aaacttccat ctccaataac ggcgatccgc tcccgcttgc tatgagcaag agtcaataga
     4261 cgattcatag cgtgcatgcc cacactgaca aactctgtaa tggctgcaac cgtatcttca
     4321 atagcatcat aagccaccac acgatcttta gggagagaaa caaactctct cataaagcca
     4381 tcaaatccac tagacaagaa atgggtccct gtcatgtagt tttcatagaa ttcttcatca
     4441 ctctgcatag gagactgatt gggaatcatg acaacttttt gaccaacctc gtaggttccg
     4501 gtcgggtcag aaatgacggt tccacatgac tcgtgaatca ttgccattgg aagcttttta
     4561 ttcaaaatct tgggatcacg ttttccctga tagtaacgct gatccgcatg acagacagcc
     4621 atgtagttgg gacggataag gatatgattc tcttggtcaa tagcctcttc ctgatatttg
     4681 acattgataa acttaggctt agttagttga taaatttgat taatcatttt actagtcttt
     4741 ctcaatcata ctttttgcaa tcttcaaatc tgttacggtt gtaatcttca gatttgagta
     4801 ttcacctttg gccaaggcca catcttttcc tttgatcaca aagattttac atgcatctgt
     4861 caagatttcc ttctcttcat cagaaagaga tccataaagg tccatgaagt ccttgcaacg
     4921 gaatgtttga ggtgtttgtc cttgataaag gtgagcacga tttggaatat ctgtaataaa
     4981 ttgaccattg gtactttcaa cgatagtatc aaccgcttct accactgtgt ccactgcgtc
     5041 atgattttgg gcaagttgga tattgtcctg aatcatgcga agtgtaataa atggacgaac
     5101 agaatcgtgg gtaacaacga tatcctctgg agtaagcgga cgataagcat caatggcttc
     5161 aatgattttc ttaatacttg tattgcggtc agcaccaccc tttgtaatga tgatacgttc
     5221 cttataaaga ggaagatatt tatctacaag atcttctgca tgagaaaccc agtctccatg
     5281 aacaccaact acaatttttt caatacttgg ctccaagaca aatttttcaa ttgtatgaat
     5341 caaaataggt cgatcaccta gctctaaaaa ttgttttggc aagttactga tccccatgcg
     5401 tgtgccagtt ccaccggcaa gaattcctgc ataaatcatc tattttctcc tttgtcttac
     5461 taaaaaaact tattctctct attataccac aatctagtcc tatcataaaa gaaatactgg
     5521 tcctcccctt ctagaatagg agaattatgc agttctatta ttcaaagaaa ctagtccatt
     5581 tctagtaatg actaggaatt ctgtagcaat tactaataaa tggctgcgaa attttagagt
     5641 ccttcagaat aatatacttt ccttaaagaa aacttaaaac ttaagatttg aaacttcaaa
     5701 gtgattactt gacttactgc ccttcatttc ttattagcta actttatgat ataatgaaaa
     5761 acgaggtaaa ttgaatgaaa agtataaaat taaatgctct atcttacatg ggaattcgtg
     5821 tcttgaatat tatttttccc atcctaactg gaacctatgt cgcgcgtgtc ttggaccgaa
     5881 ctgactatgg ttacttcaac tcagtcgaca ctattttgtc atttttcttg ccctttgcaa
     5941 cttatggtgt ctataactac ggtttaaggg ctatcagtaa tgtcaaggat aacaaaaaag
     6001 atcttaacag aaccttttct agtctttttt atttgtgcat cgcttgtacg attttgacca
     6061 ctgctgtcta tatcctagcc tatcctctct tctttactga taatccaatc gtcaaaaagg
     6121 tctaccttgt tatggggatt caactcattg cccagatttt ttcaatcgaa tgggtcaatg
     6181 aagctctgga aaattacagt tttctctttt acaaaactgc cttcatccgt atcctgatgc
     6241 tggtctctat tttcttattt gttaaaaatg aacacgatat tgttgtctat acacttgtga
     6301 tgagtttatc gacgctgatt aactacctga ttagttattt ttggattaaa agagacatca
     6361 aacttgttaa aattcaccta agtgatttta aaccactctt tctccctctg acagccatgt
     6421 tagtctttgc caatgccaat atgctcttca cttttttaga tcgcctcttc ctcgttaaaa
     6481 cagggattga tgtcaacgtt agttactata ccatagctca gcgaattgtg accgttatag
     6541 ctggggttgt aacaggtgca attggagtga gtgtgcctcg tctcagttac tatctgggga
     6601 aaggagacaa agaagcctat gtttctctgg ttaatagagg tagtcgaatc tttaacttct
     6661 ttatcattcc actgagtttt ggactcatgg ttttaggacc aaatgccatc ctactttacg
     6721 gtagtgaaaa atatatcgga ggcggcatct tgacctctct cttcgctttt cgtacgatta
     6781 tcctggcctt agataccatt cttggttccc aaattctctt taccaatggc tatgaaaaac
     6841 gtatcacagt ctatacagtc tttgctgggc tactcaattt gggcttgaat agtctcctct
     6901 ttttcaacca tatcgtggct cctgaatact acttactgac aactatgtta tcagagactt
     6961 ctctacttgt tttctatatc attttcatcc atagaaaaca actcatccac ttgggacata
     7021 tctttagcta tactgttcga tactctctct tttcactttc ctttgtagca atttatttcc
     7081 tgattaattt catgtatcct gtggatatgg tcattaattt gccatttttg attaatactg
     7141 gtttgattgt cttgctatca gctatctctt atattagtct acttgtcttc acaaaagata
     7201 gcattttcta tgaattttta aaccatgtcc tagccttaaa aaataaattt aaaaaatcat
     7261 aggagtttaa aatgaaacaa ctaaccgttg aagatgccaa acaaattgaa ttagaaattt
     7321 tggattatat tgatactctc tgtaaaaagc acaatatcaa ctatattatt aactacggta
     7381 ctctgattgg ggcggttcga catgagggct ttatcccttg ggacgacgat attgatctgt
     7441 ccatgcctag agaagactac caacgattta ttaacatttt tcaaaaggaa aaaagcaagt
     7501 ataagctcct atccttagaa actgataaga actactttaa caactttatc aagataaccg
     7561 acagtacgac taaaattatt gatactcgaa atacaaaaac ctatgagtct ggtatcttta
     7621 tcgatatttt ccctatagat cgctttgatg atcctaaggt cattgatact tgttataaac
     7681 tggaaagctt caaactgctg tctttcagta aacataaaaa tattgtctat aaggatagcc
     7741 ttttaaaaga ttggatacga acagcctttt ggttgctcct tcgaccagtt tctcctcgtt
     7801 attttgcaaa taaaatcgag aaagaaattc aaaaatatag tcgtgaaaat gggcagtata
     7861 tggcttttat cccttcaaaa tttaaggaaa aggaagtctt cccaagtggt acctttgata
     7921 aaacaatcga tttacccttt gagaatttaa gccttcctgc acctgaaaaa tttgatacta
     7981 ttttgacaca attttatgga gattatatga ccctaccacc agaagaaaaa cgcttctaca
     8041 gtcatgaatt tcacgcttat aaattggagg attaggatgc aatatttaga aaaaaaagaa
     8101 attaaagaaa ttcaactagc cctgctggac tatattgatg agacttgtaa gaaacatgat
     8161 attccttatt ttctcagtta tggaaccatg cttggagcca tccgccacaa aggtatgatt
     8221 ccttgggatg atgatattga tatttccctt tatcgtgagg attatgagcg tttactgaag
     8281 attattgaag aagaaaatca ccatcgctac aaggttcttt cctacgatac atcttcttgg
     8341 tacttccata atttcgcatc gattttggac acttctactg ttatagaaga ccatgttaag
     8401 tacaagcgtc atgataccag ccttttcatc gatgtcttcc caattgatcg atttacagac
     8461 ttgagcattg tcgacaagag ctataagtat gtggcccttc gtcaactagc ttatatcaaa
     8521 aaatcacgag cagttcacgg tgatagcaaa ctaaaagatt ttcttagatt atgtagctgg
     8581 tacgctctcc gatttgtcaa tcctcgctac ttttacaaga aaattgatca actagtcaaa
     8641 aatgctgtaa ccaacactcc tcaatatgaa ggaggagttg ggatcggtaa ggaagggatg
     8701 aaagaaatct tcccagttga tacctttaaa gaactgattt taactgagtt tgagggccgt
     8761 atgttgcctg ttcccaaaaa atatgaccaa tttttaaccc agatgtatgg cgattatatg
     8821 acaccaccat caaaagaaat gcaagagtgg tatagtcata gcattaaagc ttatcgcaaa
     8881 aactgattga gggggattat acaaactact aagatagagg ttattcaaaa acataatttt
     8941 agtagaaaat gaaataca
//
LOCUS       DAVHIZ010000066         8922 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.068, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000066 DAVHIZ010000000
VERSION     DAVHIZ010000066.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8922)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8922)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8922
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.068"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            122..277
                     /locus_tag="VVO18_001791"
                     /pseudo
     CDS             122..277
                     /locus_tag="VVO18_001791"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
     gene            477..3752
                     /gene="rexB"
                     /locus_tag="VVO18_001792"
     CDS             477..3752
                     /gene="rexB"
                     /locus_tag="VVO18_001792"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002206154.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="HEU5586892.1"
                     /translation="MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKER
                     AVLECLSQQASFSITVTRFAQMARYLVLNDLPVKTTLDDIGLGLAFYKCLAELDPKDL
                     RFYGAIKQDPQLIQQLIELYHEMTKSQMSFLDLENLTDEDKRTDLLLIFEKVTAYLNQ
                     GQLAQGSQLSHLIEAIENDKVSSDFNQITLVIDGFTRFSAEEERVVDLLHGKGVEIVI
                     GAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLE
                     SSYDFSELALDIDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILL
                     GDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLL
                     RTDLYTDLSQSDIDSFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAP
                     LETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVL
                     EQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYA
                     IGLTQDNLPKISQNTSLLTDEERQNLNQTTEEGVQLLIASSENLKKNRYTMLSLVNSA
                     RKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSL
                     VAYHQQGEMSDIERDLTFVKVLSRVIGKKLDLQGLENPAIPTSPSSKTLAKDTLQALY
                     PAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLRPDARSHGNFLHRIFERALQL
                     PNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIE
                     TIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPH
                     FFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKY
                     QGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYT
                     ENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWFEKIREE
                     LNR"
     gene            3749..7399
                     /gene="addA"
                     /locus_tag="VVO18_001793"
     CDS             3749..7399
                     /gene="addA"
                     /locus_tag="VVO18_001793"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000767270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase-exonuclease AddAB subunit AddA"
                     /protein_id="HEU5586893.1"
                     /translation="MKLIPFLSEEEIQKLQEAEANSSKEQKKTAEQIEAIYTSGQNIL
                     VSASAGSGKTFVMVERILDQLARGVEISQLFISTFTVKAATELKERLEKKISKKIQET
                     DDVDLKQHLGRQLADLPNAAIGTMDSFTQKFLGKHGYLLDIAPNFRILQNQSEQLLLE
                     NEVFHEVFEAHYQGKQKESFSHLLKNFAGRGKDERGLRQQVYKIYDFLQSTSNPQKWL
                     SESFLKGFEKADFTSEKEKLTEQIKQALWDLESFFRYHLDNDAKEFAKAAYLENVQLI
                     LDEIGSLNQEFDSQAYQAVLARVVAISKEKNGRALTNASRKADLKPLADAYNEERKTQ
                     FTKLGQLSDQIAILDYQERYHGDTWKLAKTFQSFMSDFVEAYRQRKRQENAFEFADIS
                     HYTIEILENFPQVRESYQERFHEVMVDEYQDTNHIQERMLELLSNGHNRFMVGDIKQS
                     IYRFRQADPQIFNEKFQRYAQNPQEGKLILLKENFRSSSEVLSATNDVFERLMDQEVG
                     EINYDNKHQLVFANTKLTPNPDNKAEFLLYDKDDTGEEEESQTETKLTGEMRLVIKEI
                     LKLHQEKGVTFKEIALLTSSRSRNDQILLALSEYGIPVKTDGEQNNYLQSLEVQVMLD
                     TLRVIHNPLQDYALVALMKSPMFGFDEDELARLSLQKAEDKVHENLYEKLVNAQKMAS
                     SQKGLIHTALAEKLKQFMDILASWRLYAKTHSLYDLIWKIYNDRFYYDYVGALPNGPA
                     RQANLYALALRADQFEKSNFKGLSRFIRMIDQVLEAQHDLASVAVAPPKDAVELMTIH
                     KSKGLEFPYVFILNMDQDFNKQDSMSEVILSRQNGLGVKYIAKMETGAVEDHYPKTIK
                     LSIPSLTYRQNEEELQLASYSEQMRLLYVAMTRAEKKLYLVGKGSREKLEVKQYPAAK
                     NGKLNSNTRLQARNFQDWLWAISKVFTKDKLNFSYRFIGEDQLTREAIGELETKSPLQ
                     DSSQADNRQSDTIKEALEMLKEVEVYNTLHRAAIELPSVQTPSQIKKFYEPVMDMEGV
                     EIAGQGQSVGKKISFDLPDFSTKEKVTGAEIGSATHELMQRIDLSQQLTLASLTETLK
                     QVQTSQAVRDKINLDKILAFFDTVLGQEILANTDHLYREQPFSMLKRDQKSQEDFVVR
                     GILDGYLLYENKIVLFDYKTDRYDEPSQLVDRYRGQLALYEEALSRAYSIENIEKYLI
                     LLGKDEVQVVKV"
     gene            7614..8792
                     /locus_tag="VVO18_001794"
     CDS             7614..8792
                     /locus_tag="VVO18_001794"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586894.1"
                     /translation="MTLPVRKSLHDAVLQASKADTWEQATKEWNEVSLIFNGIGRSNC
                     VCGNAIKYAYELFNGVTGQRLFPIGSDCVRHFHRLSLDQQLEEEEKLLRKVENLTRKA
                     QKKEKIKVNKSDFDERLLKWLWEKGVFKPNRGNQFAPERDYQLFLEVFQGGSWTKAEP
                     KKKARMEEVLEKCIKPFLLGKSDDQLYLVKLGKEKIDYEQELRIQAEKERKKRDKIAK
                     QYADNLVLAMGPAERAYQDYFGFTETLTQEERKWEKILFGKNRAERAIKAKQYQKELE
                     KDQRIASQDPIERKQKQTWLLNSYFRELPEEKARFSRLLLEYRKSGEVPFSTEYLSDH
                     LIDFFYKMKAFEFEIAPEQVRDFLKKSLQEDHRSSAQGSWIEGILLNCLKPFLERLVI
                     "
BASE COUNT         2762 a         1862 c         1891 g         2407 t
ORIGIN      
        1 tagattgaaa taagatacga acagcttgat tagggaaatc aaattaattt ctagcaatat
       61 tttagcatcc acggtgtact attatagttt caatttacta tagttcaatc attctatcaa
      121 gaatattgaa tatataaagg cacgtaatat taaaacttct tctgatatcg aattagagtc
      181 cgatgttgat ggcgataaat cagacaatct acccgtcgac attaagatac tgggacaaca
      241 cattgaagtg tattccgtac ctaagaaaca atcataaaac tcaaagtctt gttaccgagg
      301 cttttttatt atgtgatttt cagtagccag acttattcta tctaatacaa gtaaagctaa
      361 gtatttaaga tttagcagat gatgaagaaa agaaaggatg gcctaaatat tttaacagat
      421 ttacgaggct aatcatggta taatataggg tgatgaaaaa ttccaacgag gctgagatga
      481 aattacttta tactgatatt cgaacttctt tgacagaaat tctaacaaga gaggcagaag
      541 agctagttgc agctggcaag cgggtcttct acattgcccc caactctctt tcttttgaaa
      601 aggaacgcgc cgtgctggaa tgcttgtccc agcaggcttc tttttcgatt accgtcacgc
      661 gctttgctca aatggctcgt tatctggtct tgaatgattt accagttaaa actactcttg
      721 atgatatcgg tcttgggttg gccttttaca aatgccttgc cgaactcgat cccaaggact
      781 tgcgttttta tggcgctatt aagcaggatc ctcaattgat ccagcagtta attgagcttt
      841 accatgagat gaccaaatct cagatgagtt ttttggactt ggagaattta acagatgagg
      901 ataagaggac ggatttactc ttgatttttg agaaagtaac agcctatctt aatcaagggc
      961 agttagccca gggaagtcag ttgtcccatt tgattgaggc tattgagaat gacaaggtaa
     1021 gtagtgattt taatcaaatc accttggtca ttgacggctt tactcgtttt tctgctgagg
     1081 aagagcgggt tgtggactta cttcacggca aaggtgttga gattgttatc ggggcttatg
     1141 ctagtaagaa agcctatacc agtcctttta gcgagggcaa tctctaccaa gccagcgtaa
     1201 aatttctcca tcatctggct tctaaatacc aaacgcctgc tcaggactgt tctcaaactc
     1261 atgagaagat ggatagtttt gacaaggcct ctcgtttgtt ggagtcttct tatgactttt
     1321 cagaactcgc tttggatatc gatgagaaag accgtgaaaa tttacaaatc tggtcttgtt
     1381 tgacgcaaaa ggaggagttg gagctagtag cccgtagcat tcgtcagaaa ttacatgaga
     1441 actcagacct gagctacaag cattttcgta ttctcttggg ggatgtagct tcttaccagt
     1501 tatctctcaa aaccattttt gaccagtatc agattccttt ttatcttggt agaagcgaag
     1561 ccatggctca tcatcccttg actcagtttg tcgagtctat tttagcttta aaacgttacc
     1621 gttttcgtca ggaggatttg attaatcttc ttagaactga tttgtatact gacctcagtc
     1681 agtctgatat tgattctttt gagcaatata tccgctatct tggtatcaat ggcttgccag
     1741 cctttcagca aaccttcacc aaatcccacc atggaaaatt taatcttgag cgtttgaatg
     1801 tcctccgcct gagaatttta gcacctcttg aaaccctctt tgccagccga aaacaaaagg
     1861 ctgaaaacct cctacaaaaa tggagtgtct ttctaaaaga aggagctgtg accaagcagt
     1921 tacaagattt gacaaccact ttggaagctg tagaacagga aagacaagcc gaagtttgga
     1981 aggctttctg ccatgtttta gaacaatttg cgactgtttt tgctggttca caggttagtc
     2041 tggaagactt cctagccttg ctccattctg gaatgagttt gtcccaatac cgtaccattc
     2101 cagcaacagt ggacactgtt ctggtgcaga gttacgattt gattgcacca ttgactgctg
     2161 actttgtcta tgctattgga ctaactcagg acaatttacc aaaaatttct caaaacacca
     2221 gtcttctgac agatgaagaa aggcaaaacc taaaccaaac gaccgaagaa ggcgttcaat
     2281 tactgattgc cagcagtgaa aatctcaaga aaaatcgcta cactatgctt tccttggtca
     2341 attctgctcg taagcagttg ttcttgtcgg ctccaagcct ttttaacgaa agtgaaagta
     2401 aggaatctgc ctatcttcaa gagttgatcc attttggatt taggcggaga gagaagagga
     2461 tgaatcacaa aggactgtct aaggaggata tggggtccta tcacagtctt ttgtctagtc
     2521 tggttgccta tcaccagcag ggtgagatga gcgatattga gcgagatttg acttttgtca
     2581 aggttctgtc gcgtgtcata ggtaaaaaac tagatctgca aggtctggaa aatccagcta
     2641 tcccaaccag tccaagcagc aagaccttag ccaaggacac cttgcaagct ctctatcctg
     2701 ccaaacagga gttttacctg tctacgtcgg gtttgacaga gttttatcgc aatgaataca
     2761 gttatttcct acgctacgtt ttaggcttgc aggaggaatt acgtttgcgt cctgatgccc
     2821 gtagtcacgg gaatttcttg catcgtatct ttgaacgcgc cttacagttg cctaatgaag
     2881 attcctttga ccaacgtcta gaacaagcta ttcaagaaac cagtcaagaa cgcgaatttg
     2941 aagctattta tcaagaaagt ttggaagccc agtttaccaa ggaagttttg cttgatgttg
     3001 cacggacgac tggacatatt ctccgacaca atccagccat cgaaaccatc aaagaagaag
     3061 caaattttgg tggaaaagac caagccttta ttcaattaga caatggacgc agtgtctttg
     3121 tacgaggcaa ggtggaccgg attgaccgtt tgaaagctaa tggagcgata ggagtagtag
     3181 actacaaatc cagtctgact cagttccagt ttcctcattt ctttaatggg ctcaattctc
     3241 agttaccaac ctatcttgct gccctaaaaa gagaagggga gcagaacttt ttcggtgcca
     3301 tgtacttgga aatggctgaa cctgtccaat ctctgatggc ggtaaaaagt ctggcaggag
     3361 cagtggtaga agccagcaaa tctatgaaat accaagggct cttcttggaa aaagaaagca
     3421 gttatttagg cgaattttat aacaaaaaca aggctaatca actgacagat gaggaatttc
     3481 agctcctact ggactacaat gcctatcttt acaagaaagc tgctgagaag attttagcag
     3541 gccggttcgc catcaatcct tatactgaaa atggcagaag cattgcccca tacgtccagc
     3601 aacatcaggc tattacaggc tttgaagcca attaccatct gggccaagcc cgtttcctag
     3661 aaaaattgga cctagctgat ggcaagcgtc tggtcggaga aaaactcaag caagcttggt
     3721 ttgaaaaaat aagagaggag ttaaatcgat gaagcttatt ccctttttaa gtgaggagga
     3781 gattcaaaaa ctgcaagaag cagaagcaaa ttcgagcaag gaacagaaga aaactgccga
     3841 acaaatcgaa gctatctaca cttctggtca gaatatcctg gtctcagcat cggctggttc
     3901 tggaaagacc tttgtcatgg tagagcgcat tctggaccaa ttggcgcgtg gtgtcgaaat
     3961 ttctcaactc tttatctcaa cctttaccgt caaggctgca actgaactta aagaacgttt
     4021 agagaaaaaa atcagcaaga aaatccaaga aacagatgat gtcgatctca aacaacactt
     4081 gggtcgccag ttggcagacc tacccaacgc tgccatcgga accatggact ctttcacaca
     4141 aaaattcctt ggcaaacatg gttatctgct tgatattgca cctaatttcc gtattttaca
     4201 aaaccaaagc gagcaacttc ttctcgaaaa cgaagtcttt catgaggtct ttgaagcgca
     4261 ttaccaaggt aaacagaaag agagctttag tcatttgctg aaaaactttg ctgggcgtgg
     4321 caaggacgaa cggggtctgc ggcagcaagt ctataaaatc tatgacttcc tccaatccac
     4381 cagtaatcct caaaagtggc tgagtgaatc tttcctcaaa ggctttgaga aagctgattt
     4441 taccagtgaa aaagaaaaac tgactgagca aatcaaacaa gccctctggg atttggaaag
     4501 ctttttccgt taccatctgg ataacgatgc caaggagttt gcaaaggctg cctatttaga
     4561 aaatgttcag ttaattctgg atgaaattgg ctccctaaat caggagttcg atagtcaggc
     4621 ttatcaggca gtacttgcgc gtgttgtcgc catctctaag gagaaaaacg gtcgtgctct
     4681 gactaatgcc agccgtaagg ctgatttgaa gcccctggct gatgcctaca acgaagagag
     4741 aaagacccag tttactaaac taggacaatt atcagaccag atagcgattc tcgactatca
     4801 agaacgttat catggagaca cttggaaact agctaaaacc ttccaatctt tcatgagcga
     4861 ttttgtagag gcttatcgtc agagaaaacg acaggaaaat gcctttgaat tcgctgatat
     4921 cagccattac accattgaga ttttagaaaa tttcccacaa gttcgtgagt cttatcagga
     4981 gcgcttccat gaagtcatgg tcgatgagta tcaggatacc aaccatattc aagaacggat
     5041 gctggaattg ttgtctaatg gccacaatcg ctttatggtg ggagatatca agcaatccat
     5101 ctatcgtttc cgtcaggcag acccgcagat tttcaatgag aaattccaac gctatgcgca
     5161 aaatccccaa gaaggcaagc tcattctcct caaggaaaat ttccgtagta gttcagaagt
     5221 gctgtcagca accaatgatg tctttgaacg tctcatggac caagaggtcg gcgaaatcaa
     5281 ctatgataac aagcaccagc ttgtttttgc caataccaaa ctgactccca atccagacaa
     5341 caaggcagaa tttctcctct acgacaagga cgatacaggt gaggaagaag agagtcaaac
     5401 agaaacgaaa ctaacaggcg aaatgcgctt agttatcaag gagattctga aacttcatca
     5461 agaaaaaggt gttaccttta aggaaattgc ccttctgacc tccagccgca gtcgtaatga
     5521 ccagattctc ctcgccctgt ctgagtacgg gattcctgtc aaaactgacg gagagcaaaa
     5581 caattatctc caatccctag aagtgcaagt catgctagac actcttcgtg tcattcacaa
     5641 tcccctgcaa gactatgcct tggttgccct tatgaagtct ccaatgtttg gttttgatga
     5701 ggatgagcta gcacgtttgt cccttcagaa agcagaggat aaagtccacg aaaatctcta
     5761 tgagaaactg gtcaatgcac aaaaaatggc aagtagtcaa aaaggcttga ttcacacagc
     5821 tctagctgaa aaactaaagc aattcatgga tatcctagct tcttggcgct tgtatgccaa
     5881 aacccactct ctctatgact tgatttggaa gatttacaac gaccgttttt attatgacta
     5941 tgttggggct ttgccgaatg gtcctgctag gcaggccaat ctctatgccc tagcactgcg
     6001 tgctgatcaa tttgaaaaga gcaatttcaa aggtttgtcg cgttttattc gtatgattga
     6061 ccaagtctta gaagcccagc acgatttggc aagcgtggcc gtcgcaccgc caaaagatgc
     6121 agtagagctc atgaccatcc acaagagtaa agggctggag tttccttacg tctttatcct
     6181 caatatggat caagatttca acaagcaaga ctctatgtca gaagtcattc tcagtcgtca
     6241 gaatggtctt ggtgtcaaat atattgccaa gatggagaca ggggcagtag aagaccacta
     6301 tcctaaaacc atcaaactct ccattcctag tctgacctat aggcagaacg aagaggaatt
     6361 acagctagca agctattctg agcagatgcg tttgctgtat gttgctatga cgcgggctga
     6421 gaaaaagctc tatcttgtcg gcaagggttc tcgtgaaaag ctggaagtca agcaataccc
     6481 agcagccaaa aatgggaaac taaatagcaa tactagactg caagcacgga atttccaaga
     6541 ttggctttgg gctatcagta aagtgtttac taaggacaag ctcaacttta gttatcgttt
     6601 tattggcgaa gatcagttga ccagagaagc tatcggagag ttggaaacca agagtcctct
     6661 ccaagatagc tcccaagcag acaatcgtca gtcagatacc atcaaagaag ctctggaaat
     6721 gctgaaggag gtggaagttt ataatactct tcaccgcgca gctattgaac ttcctagtgt
     6781 tcaaacccca agtcaaatca agaaattcta cgaaccagtt atggatatgg aaggtgtcga
     6841 gattgctggt caaggtcagt cagtaggcaa gaaaatcagc ttcgatttgc cagatttttc
     6901 aaccaaagaa aaggtaactg gagctgagat tggtagtgct actcacgaac tcatgcagag
     6961 aattgacctc agccagcaac taacccttgc tagcctaaca gaaacactca aacaagttca
     7021 aactagccaa gctgtcagag acaagatcaa tcttgataaa attcttgctt tctttgacac
     7081 agtactcggt caggaaattc ttgctaatac cgaccatctc tatcgcgagc aacctttctc
     7141 catgctcaaa cgagaccaaa agagtcagga agactttgtt gtccgtggta tccttgatgg
     7201 ctatctgctt tacgaaaaca aaattgttct gttcgactac aagacagacc gctatgatga
     7261 accaagtcaa ctcgtagacc gctatcgtgg tcagttagct ctatacgaag aggctttatc
     7321 acgagcctat tcgattgaaa atattgaaaa atacttgatt ttactcggta aagacgaggt
     7381 tcaagttgta aaagtataac ttatactctt tgaaaatctc ttcaaaccac gtcagcttcg
     7441 ccttgctgta tatatggtta ctgacttcgt cagttctatc cacaacctca aaacagtgtt
     7501 ttgagctgac ttcgtcagtt ctatctacaa cctcaaaaca gtgttttgag ctgattgcgg
     7561 ctagctttct agtttgctct ttgattttta ttgagtatta gaaaggagac ctcatgacac
     7621 ttccagttag aaaatccctg cacgatgcag ttttacaggc ttcgaaagcg gatacttggg
     7681 aacaagctac caaggaatgg aatgaagttt ccttgatttt taacggtatc ggccgtagca
     7741 attgtgtctg tggaaatgcc atcaaatacg cttatgaact ctttaacggt gtcacaggcc
     7801 aacgcctctt tccaattggt agcgactgtg ttcgtcattt tcatcgattg tcccttgacc
     7861 agcaattgga agaggaagaa aaactgctca gaaaggttga aaatctaacc agaaaagctc
     7921 agaaaaagga aaaaatcaag gtcaataaaa gtgactttga cgagcgactt ctaaaatggc
     7981 tctgggaaaa aggtgttttc aaacccaatc gtggcaatca atttgcgcct gagagagact
     8041 accagctttt cctagaagtc tttcagggag gaagttggac caaggcggaa ccaaagaaaa
     8101 aggctcggat ggaagaagtc cttgaaaagt gtatcaaacc ctttttactt gggaaatcgg
     8161 atgaccaact ctaccttgtc aagctaggca aggagaaaat tgactacgaa caagaactcc
     8221 gtatccaggc agagaaagaa cgcaagaaga gggataaaat cgccaagcaa tatgcagaca
     8281 atctggttct agccatggga cccgcagagc gtgcttatca agattacttt ggctttacag
     8341 agaccctgac tcaagaagaa cgcaagtggg aaaaaattct ttttggtaaa aatagagcag
     8401 aacgggctat caaggccaaa caataccaaa aagagctgga aaaagaccaa cgaattgcca
     8461 gtcaggatcc aattgaaaga aaacagaagc agacttggct cctcaattcc tattttcgtg
     8521 agcttcctga agaaaaagct cgattttcta ggctcttatt agaatatcga aaaagtggtg
     8581 aagtaccctt ttcaactgaa tacctgtccg atcatctcat cgactttttc tataaaatga
     8641 aagcctttga atttgaaatc gcaccagaac aagtccgaga ttttctaaaa aaaagcctgc
     8701 aggaagacca tcgctcatca gcacaaggaa gctggataga aggaattctc ctcaactgcc
     8761 tcaaaccatt tttagaacga ttagtgatat gagtaacacc taccgtgtaa atttcatggt
     8821 aggtgttatt gtacccccaa ataatataaa acaaagtatg aaagcgcatc tcaattttaa
     8881 gacttttttg taaattaaga gtataattaa ggtatactgc ct
//
LOCUS       DAVHIZ010000067         8777 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.069, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000067 DAVHIZ010000000
VERSION     DAVHIZ010000067.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8777)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8777)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8777
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.069"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            7..999
                     /locus_tag="VVO18_001795"
     CDS             7..999
                     /locus_tag="VVO18_001795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410752.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="HEU5586895.1"
                     /translation="MNGKKVTIYDIARLSGFSPKTVSRVINGGVNVKEETYQAIQKVI
                     EELSYIPNAYAKNLTKKEAINILISVKKIDSFPLIWFHTLLDKVLRTCKEFGVNAIVE
                     YFGEEDTISNSIISSTGSLVDGVIVFYESVDDIRIQYLKKNHMPFLVFGESQTSGVVY
                     VSNNNFQATYDMMKAVTEEKFKNMWLLMGGESHVNKDRERGVRSFLNDKNYFMDLKVI
                     YGLSTIDSVYSYAMQHLTTQNYPDIIFVSGDEKVQGLIRACYEKGILIPDDISIIGFD
                     NIPISQYYTPALSTIAPNYVKLAKEMIEGVLAIIKGESVTSVEVSPKFVRRQSF"
     gene            1601..1681
                     /locus_tag="VVO18_001796"
                     /pseudo
     CDS             1601..1681
                     /locus_tag="VVO18_001796"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            2320..3681
                     /gene="trpE"
                     /locus_tag="VVO18_001797"
     CDS             2320..3681
                     /gene="trpE"
                     /locus_tag="VVO18_001797"
                     /EC_number="4.1.3.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate synthase component I"
                     /protein_id="HEU5586896.1"
                     /translation="MERIIHGDVLSPILAYMRLKGQHKVILESIPRDKETARFSILAY
                     NPIFEIKFENGVLYQNGQVIDRDPLDFLYEVIHKSQHHSELPFGGGAVGFVGYDMISL
                     YEEIGQIPEDTIGTPDMHFFVYESYMVFDHKKEKIHVIEDALYSERSQEALEKSLNQV
                     LEELRIPAPNEFEDLDLSPLDFKPHIAPQKFEEMVETARDLIRNGDMFQCVLSQRFSA
                     EVTGNPFDFYRNLRVTNPSNYLYFYDFGDYQIIGASPESLVSVKNGIVTTNPIAGTRP
                     RGATDEEDKTLATDLLSDEKETAEHRMLVDLGRNDIGRISETASVQVTKYMEVELFRY
                     VMHLTSVVKGRLLAELTAMDALKATLPAGTVSGAPKIRAMRRIYELETEKRGVYAGAI
                     GYLSATGDMDLAIAIRTMILKNQRAYVQAGAGIVYDSIAQNEYQETINKAKSMTRIGE
                     LRP"
     gene            3678..4244
                     /locus_tag="VVO18_001798"
     CDS             3678..4244
                     /locus_tag="VVO18_001798"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009730493.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminodeoxychorismate/anthranilate synthase
                     component II"
                     /protein_id="HEU5586897.1"
                     /translation="MILLIDNYDSFTYNLAQYIGNFAEVQVLRNDDSKLYEEAEKADG
                     LVFSPGPGWPVDAGKMEDMICDFAGKKPILGICLGHQAIAEVFGGKLGLAPKVMHGKQ
                     SNINFEAPSVLYQGIEDGRAVMRYHSILIEEMPEDFEVTARSTDDQAIMGIQHKNLPI
                     YGFQYHPESIGTPDGLSSIRNFIEEVVK"
     gene            4255..5259
                     /gene="trpD"
                     /locus_tag="VVO18_001799"
     CDS             4255..5259
                     /gene="trpD"
                     /locus_tag="VVO18_001799"
                     /EC_number="2.4.2.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517337.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="HEU5586898.1"
                     /translation="MKEIIEKLAKFENLSGVEMTDVIERIVTGRVTEAQIASLLLALK
                     MKGETPEERTAIAQVMRGHAQHIPTEIHDAMDNCGTGGDKSFSFNISTTAAFVLAGGG
                     IHMAKHGNRSISSKSGSADVLEALGINLDLKPAELGKVFDKTGIVFLFAKNMHPAMKY
                     IMPARLELGIPTIMNLTGPLIHPMALETQLLGISRPELLESTAQVLKNMGRKRAIVVA
                     GPEGLDEAGLNGTTKIALLENGEISLSSFTPEDLGMEDYAMEDIRGGNAQENAEILLS
                     VLKNEASPFLETTVLNAGLGFYANGKIDSIKEGVALARQVIARGKTLEKLRLLQEYQK
                     "
     gene            5256..6023
                     /gene="trpC"
                     /locus_tag="VVO18_001800"
     CDS             5256..6023
                     /gene="trpC"
                     /locus_tag="VVO18_001800"
                     /EC_number="4.1.1.48"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011227478.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="indole-3-glycerol phosphate synthase TrpC"
                     /protein_id="HEU5586899.1"
                     /translation="MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDC
                     LQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREIS
                     SQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
                     ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTG
                     QDAERLAPYFNGILVGTALMQAENVAQRIKELQIDKG"
     gene            6010..6609
                     /locus_tag="VVO18_001801"
     CDS             6010..6609
                     /locus_tag="VVO18_001801"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="HEU5586900.1"
                     /translation="MTKVKICGLSTKEAVETAVSAGADYIGFVFAPSKRQVTLEEAAE
                     LAKLIPADVKKVGVFVSPSRVELLEAIDKVGLDLVQVHGQVAADLFENLPCASIQAVQ
                     VDGNGHVPNSQADYLLFDAPVAGSGQSFDWGQLDTTGLAQPFFIAGGLNEDNVVKAIQ
                     HFTPYAVDVSSGVETDGQKDHEKIRRFIERVKHGISGTK"
     gene            6587..7810
                     /gene="trpB"
                     /locus_tag="VVO18_001802"
     CDS             6587..7810
                     /gene="trpB"
                     /locus_tag="VVO18_001802"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331289.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HEU5586901.1"
                     /translation="MAYQEPNKDGFYGKFGGRFVPETLMTAVLELEKAYRESQADPSF
                     QEELNQLLRQYVGRETPLYYAKNLTQHIGGAKIYLKREDLNHTGAHKINNALGQVWLA
                     KRMGKKKIIAETGAGQHGVATATAAALFNMECTIYMGEEDVKRQVLNVFRMELLGAKV
                     EAVTDGSRVLKDAVNAALRSWVANIDDTHYILGSALGPHPFPEIVRDFQSVIGREAKQ
                     QYRDLTGQNLPDALVACVGGGSNAIGLFHPFVEDESVAMYGAEAAGFGVDTEHHAATL
                     TKGRPGVLHGSLMDVLQDAHGQILEAFSISAGLDYPGIGPEHSHYHDIKRASYVPVTD
                     EEALEGFQLLSRVEGIIPALESSHAIAFAVKLAKELGPEKSMIVCLSGRGDKDVVQVK
                     DRLEADAAKKGEAHA"
     gene            7803..8579
                     /locus_tag="VVO18_001803"
     CDS             7803..8579
                     /locus_tag="VVO18_001803"
                     /EC_number="4.2.1.20"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="HEU5586902.1"
                     /translation="MPKTLTKKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLE
                     DLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTY
                     FNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGI
                     ERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQA
                     DLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK"
     gene            complement(8551..8652)
                     /locus_tag="VVO18_001804"
                     /pseudo
     CDS             complement(8551..8652)
                     /locus_tag="VVO18_001804"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000234126.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
BASE COUNT         2606 a         1630 c         2102 g         2439 t
ORIGIN      
        1 aaaaatataa atgggaaaaa ggtaactatt tatgatattg cacgtttatc aggtttttct
       61 ccaaaaacag tttcacgagt tattaatggt ggagtaaatg ttaaagaaga aacttatcaa
      121 gcgattcaaa aagttataga ggaattgtcg tatattccaa atgcgtatgc aaaaaattta
      181 actaaaaaag aagctataaa tatattgatt tctgtaaaaa aaatcgactc ttttccttta
      241 atttggtttc atacgctgtt agataaagtg ttacggacgt gtaaagaatt tggtgttaat
      301 gctatagttg agtactttgg agaggaggat acaattagta attcaattat atcaagcaca
      361 ggtagcctag tagatggtgt tattgttttt tatgaaagtg tagatgatat cagaattcag
      421 tatttaaaga agaaccatat gccttttctt gttttcggtg aatctcaaac gtctggagta
      481 gtctatgtat ctaataataa ttttcaagct acttatgata tgatgaaagc tgtaactgaa
      541 gaaaaattta aaaatatgtg gttgcttatg ggaggagaat cccatgttaa taaggatcgt
      601 gaaagaggtg tgcgttcttt tctgaatgat aaaaattact ttatggattt aaaagtcatt
      661 tatggcttat ctacaattga ttcagtttat tcttatgcaa tgcagcactt gactacccaa
      721 aattatccgg acattatttt tgtttcagga gatgaaaagg ttcagggctt gattcgtgcg
      781 tgctatgaga aaggaattct tattccagat gatatttcta tcattggatt tgataatatt
      841 cctatttctc agtattatac tccagctttg tctacaattg ctcccaatta tgttaaattg
      901 gctaaagaaa tgatagaagg tgttttagca attattaaag gggaaagtgt cacatctgtt
      961 gaagtttctc ctaaatttgt taggagacag agtttctagt attgtttaat tcttgaaaat
     1021 cctagtggaa aagatggagt gttctaaaat aagttctgtt tagcctccat tcagtttcta
     1081 ttgagttgga tccaatttct aacaagtggg acatgttcat gttcgatcta aggaagacat
     1141 ggtcacattc gaatgatatt ttcaaaaaaa tcgtaaaaaa gtcttgacaa agaaaaaaca
     1201 aagtattaaa ataagttcaa caaatcagaa aagtaactat ttttgatctt cagggagcct
     1261 gtggtgattg tgaataggtg gttggaagta gtgaaagtgg gctgattttg aaaatgaatt
     1321 tgaaacaatg aaaattcggt gcgcacacct tacagtgcag cttgttgtta aacaaggcag
     1381 agatgtaaag ggatagtccc tttataattg aggtggcacc gcgttaccaa cgccctcaca
     1441 cggaagtata ttctgtgtgt gggctttttt ctatccgtcg tttggtttat cttttattag
     1501 ggccttaagt cgctttgatg aacttgagtt ctatctacag ctccttgcct actactaaaa
     1561 gcaaacaaaa aggctggact aatacgaaaa aagctagtga tactcaatga aaatcaaaga
     1621 acaaactagg aaactagccg caggttgctc aaaacactgt tttgaggttg tggatagaac
     1681 tgacgaagtc agctcaaaat actgttttga ggttgtggat agaactgacg aagtcagctc
     1741 aaaacactgt tttgaggttg tggatagaac tgacgaagtc agctcaaaac actgttttga
     1801 ggttgtggat agaactgacg aagtcagctc aaaacactgt tttgaggttg cagatagaac
     1861 tgacgaagtc agtaaccata tctacggcaa ggcgacgttg acgcggtttg aagagttttt
     1921 cgaagagtat aaaggtgtac cgagatgaac atctcttcat caatgtctct ggtcgtggag
     1981 gcaaggacct agctgcgatt gcagactact agaagctaaa aaataataga tggaaaaatt
     2041 acagttcttt ctctcacaga gagcttgtgg ttgctgaaaa caagcagaga aagctgtaaa
     2101 gttgggttca tctgaaacga gagaagaaaa catcattctc aagggagtgc cctttatcgc
     2161 acagcctgtt acaggagata tctgagacag gaatgagaga taggagaaat cctataattg
     2221 aggtggcacc gcgaatttcg tcctcacgca agttattttg cgtggggatt tttcatacag
     2281 tcgctacgaa ctagaattag aactgaaagg aaaattacaa tggaacgaat cattcatgga
     2341 gatgtcttat caccaatctt ggcttatatg cgcttaaagg ggcaacacaa ggttatctta
     2401 gagagtattc cgagagacaa ggaaacagct cgtttttcta tcctagccta taatccaatt
     2461 tttgagatta agtttgaaaa tggagttctc tatcaaaatg gtcaagtgat tgatcgggat
     2521 cccttggatt tcctttatga agtgattcat aagagtcagc accactcaga gctacctttt
     2581 ggtggtggag ccgttggttt tgtgggttac gatatgattt cactttatga agaaattggt
     2641 caaatccctg aggatacaat tgggacgcca gacatgcatt tctttgtcta tgagagctat
     2701 atggtctttg accacaagaa ggagaagata catgtcatag aggatgcact ttatagtgag
     2761 cgcagtcaag aggccttgga aaaatccttg aaccaagtgc ttgaggaatt acgcattcct
     2821 gctccaaatg aatttgaaga cttggatcta tctccgttag acttcaaacc tcatatcgct
     2881 cctcagaagt ttgaggaaat ggtggaaaca gctcgtgact tgattcgtaa tggtgatatg
     2941 ttccaatgcg tactcagcca gcgcttttca gcagaggtta ctggaaatcc atttgacttc
     3001 tacagaaatc tccgcgtgac caatccatct aattaccttt atttctatga ctttggggat
     3061 tatcaaatca tcggtgccag tccagaaagt ttggtttctg tcaaaaatgg catcgtgaca
     3121 accaatccga ttgcagggac gcgaccaaga ggggctacgg atgaagaaga caagaccttg
     3181 gcgactgacc tcctctctga tgagaaggaa acagcagaac atcgaatgtt ggtagacttg
     3241 gggcgtaacg atattggccg catctctgaa acggccagtg tccaagttac taagtatatg
     3301 gaggtggagc tcttccgcta cgtcatgcat ttgaccagtg tggtcaaggg acgtttgctt
     3361 gcagaactca ctgccatgga tgccttgaaa gcaacgcttc ctgctggaac cgtttctgga
     3421 gcaccaaaga ttcgggcgat gagacgcatc tatgaactgg aaacggaaaa acggggcgta
     3481 tatgcaggag caatcggcta cttgtctgcg acgggtgata tggatttggc catcgccatc
     3541 cgaaccatga ttctcaaaaa tcaaagagcc tatgtgcagg ctggggcagg gattgtctac
     3601 gactctatcg cccaaaacga ataccaagaa accattaaca aagcaaaatc tatgactaga
     3661 attggagaac taagaccatg attttattga ttgacaacta tgattctttt acctataact
     3721 tggcccaata cattgggaat tttgcagaag ttcaggttct gagaaatgat gattccaagc
     3781 tgtatgaaga agctgaaaaa gcagatggtc tggtcttttc tcctggtcct ggttggccag
     3841 ttgatgctgg aaagatggaa gacatgattt gtgattttgc aggcaagaag ccgattctag
     3901 ggatttgttt gggtcaccaa gccattgcag aagtctttgg tggtaagcta ggtttggctc
     3961 caaaagtcat gcatgggaaa cagagcaata tcaactttga agcgccatct gttttgtatc
     4021 aaggtattga ggatggccgt gcggtcatgc gttatcacag tattttgatt gaggaaatgc
     4081 cagaagactt tgaagtgaca gctcgttcga ctgatgacca agccatcatg gggattcaac
     4141 ataaaaacct accaatttat ggcttccagt accatccaga gagcattgga acgccagacg
     4201 gcttgtcttc tattcggaat tttatcgagg aggttgtaaa gtgaggaaac taggatgaaa
     4261 gagattattg aaaaactagc aaaatttgaa aatttatcag gtgtggaaat gacggatgtc
     4321 attgagcgta tcgtaactgg gcgtgtaact gaagcgcaga ttgcttctct cctcttagct
     4381 cttaagatga agggggaaac acctgaagaa cgtacagcca ttgcccaagt catgagagga
     4441 catgcccagc atattccaac tgagattcat gatgctatgg acaactgtgg tacaggtggg
     4501 gacaagtctt tcagttttaa tatttccaca actgcagcct ttgtcttggc tggtggcggt
     4561 attcacatgg ccaagcatgg taaccgctcg atttcttcta aatctggttc cgcagatgtc
     4621 ctcgaagcct tgggaatcaa tcttgacctc aaaccagctg aactaggtaa ggtctttgat
     4681 aaaactggaa tcgtctttct cttcgctaaa aatatgcacc cagctatgaa atacatcatg
     4741 ccagctcgtt tggaattggg aattccaacg attatgaact tgactggtcc actgattcat
     4801 ccaatggctt tagaaacaca gcttcttgga attagtcgtc cagaactcct agaaagtaca
     4861 gctcaggttt tgaaaaatat gggtcgcaaa cgtgccatcg tggttgctgg accagaaggg
     4921 ttggatgaag ctggcttgaa cggaacaacc aagattgcac ttcttgaaaa tggcgaaatc
     4981 agcttgtcaa gctttactcc agaggatttg ggaatggaag actatgctat ggaagatatt
     5041 cgtggtggga atgctcagga aaatgcagaa attttgctta gcgttctgaa aaacgaagca
     5101 agtccattct tggaaacgac agtcttgaat gctggtcttg gtttctatgc taatggtaag
     5161 attgatagca tcaaggaagg agttgccttg gcccgtcaag tgattgctag aggcaagacc
     5221 cttgaaaaac tcagactgtt acaggagtac caaaaatgag tcaggaattt ttagcacgaa
     5281 tcttagagca gaaggcgcgt gaggtggagc agatgaagct ggagcaaatc cagcctctgc
     5341 gccagaccta tcgcttggca gaatttttga agaatcatca ggactgcttg caggtaatcg
     5401 ctgaggtcaa gaaagctagc cctagtttgg gagatatcaa tctcgatgtg gatattgtgc
     5461 aacaggccca gacttatgaa gaaaacggag cagtgatgat ttcggtgttg acagatgagg
     5521 ttttctttaa agggcatttg gattatctac gggaaatttc cagtcaggta gagattccga
     5581 cgctcaacaa agactttatc atagatgaaa agcaaatcat ccgcgctcgc aatgcaggtg
     5641 cgacagttat cttgcttatt gtggcagcct tgtccgaaga acgcctcaag gaactgtatg
     5701 actacgcgac agagcttggt ctggaagtct tagtggagac tcacaatcta gctgaactag
     5761 aggtagccca cagacttggt gctgagatta tcggggtcaa caaccgcaac ttgactacct
     5821 ttgaggtcga cttgcagacc agtgtagatt tagcccctta ctttgaggaa ggtcgctatt
     5881 acatttctga atctgccatt ttcacagggc aggatgcgga acgactagcc ccatacttta
     5941 acggaatttt ggtagggaca gctcttatgc aggcagaaaa tgtggcccag agaatcaagg
     6001 agttgcagat tgacaaaggt taaaatttgt ggactatcga ccaaagaagc ggtggaaaca
     6061 gccgtttcag caggagccga ctatatcggt tttgtctttg cacctagtaa aagacaggtg
     6121 actttagaag aggcagctga gttggcaaag cttattcctg cagatgtgaa aaaggttgga
     6181 gtatttgttt caccaagtcg ggtagaactg ctggaagcga ttgacaaagt tggcttggac
     6241 ttggttcaag ttcacggtca ggtggcagct gatttatttg agaatttgcc ttgtgccagt
     6301 attcaggctg tgcaggtaga tggaaatggg catgtcccca attctcaggc agattatcta
     6361 ctctttgatg cccctgtggc aggaagtggt cagtcctttg attggggtca actggatacg
     6421 actggactag cacagccctt ctttatcgca ggtggcctta atgaagataa tgtagtaaaa
     6481 gcaattcaac attttactcc ctatgcagta gatgtatcga gcggagtaga gacagatgga
     6541 caaaaagatc atgaaaagat tagaagattt atagagaggg taaagcatgg catatcagga
     6601 accaaataaa gatggatttt acggaaaatt cggcggacgt tttgtcccag aaacattgat
     6661 gacagcagtt ttggagttgg agaaggccta ccgtgaaagt caggcagacc caagtttcca
     6721 agaggaatta aaccagcttt tgcgccagta cgtaggacgt gaaactcctc tttattacgc
     6781 aaaaaacttg acccagcata tcggcggagc caagatttat ctcaaacggg aagaccttaa
     6841 ccatacagga gcccacaaga ttaacaatgc cttgggacaa gtttggcttg ccaaacgcat
     6901 gggtaaaaag aaaattatcg cagaaactgg tgctggtcag cacggtgtgg caactgcaac
     6961 tgctgcggcc ctctttaaca tggaatgtac catctacatg ggtgaggaag atgtcaaacg
     7021 ccaagtcctc aatgtcttcc gtatggagct tttgggagct aaggtcgagg ccgtgacaga
     7081 tggttcgcgc gtgctcaagg atgcggtcaa tgcagccctt cgttcatggg tggctaatat
     7141 agatgatacc cactatatcc ttggttctgc cttggggcct catccatttc cagaaattgt
     7201 tcgtgacttc caaagtgtca ttggtcgaga ggctaaacaa cagtaccgtg acttgacagg
     7261 acaaaatctg ccagatgccc tagtagcctg tgttggtggt gggtcgaatg ccatcggtct
     7321 cttccatccc tttgtagaag atgagtcagt agccatgtat ggagctgaag cggctggatt
     7381 tggtgtggat acggagcacc acgcagctac cttgaccaag ggtcgtccag gtgtccttca
     7441 cggttccctc atggatgtgc tccaagatgc ccatggtcaa attcttgaag ccttctctat
     7501 ctcagcaggt ttggactatc ctggtatcgg tccagagcat tctcactacc acgatattaa
     7561 acgtgccagc tatgtccctg tgacagacga agaagccttg gaaggattcc aactcttgtc
     7621 tcgtgtggaa gggattatcc cagctttgga atctagccat gctatcgcct ttgcggtgaa
     7681 attggccaaa gaacttggac cagaaaagtc tatgattgta tgcctatcag gtcgtgggga
     7741 caaggatgtg gttcaagtaa aagaccgctt ggaagcagat gcagcaaaga agggagaagc
     7801 tcatgcctaa gacactaaca aaaaaattaa atgctattaa agcagctgga aaaggaattt
     7861 ttgttcccta tatcatggct ggtgaccacg aaaaaggttt ggatggtctt gctgaaacaa
     7921 ttcacttttt agaagatttg ggtgtctctg caattgaagt gggtattccc ttttcagacc
     7981 ctgttgcaga tggacctgtt atcgaagaag ctggcttgcg cagtttagcc cacgggacct
     8041 ctacccaggc tttagttgaa accttgaaaa ccattgaaac agagattcca ctggtcatca
     8101 tgacctactt caaccccctc tttcagtacg gtgtggagaa ctttgtcaaa gatctggctg
     8161 atacagctgt gaagggcttg attatcccag acctgcctca tgaacatgcc aactttgtag
     8221 aaccattttt ggcagataca gatatcgcct tgattccttt agtaagcttg accacaggaa
     8281 ttgagcgcca gaaagagttg attgaagggg cggagggatt cgtctatgcc gttgccatca
     8341 atggggtaac agggaaatca ggcaattacc gtgcagattt ggacaagcac ttggcgcaac
     8401 ttcatcaagt ggccgacatc ccagtcttga caggttttgg tgtatctagt caagccgatc
     8461 tggaacgctt caatgcggtg tcagatggtg ttatcgtcgg ttcgaaaata gtaaaagctc
     8521 tccaccaagg agagccgatt caggacttta tcaaacaagc agtagcttac caaaaataat
     8581 taaacaagta gcaagtaaga ggaaaggcac gaaaggaagt ctttcctttt tcttttgcag
     8641 gagaaaggct agttttatag tgaattgaat ctggaatatt acactacggt tcctaaaata
     8701 ttttcagaaa gtgatttgaa tttcccaata aatttgttca gtttttaatt gattttacta
     8761 tagaagatat aattttc
//
LOCUS       DAVHIZ010000068         8185 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.070, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000068 DAVHIZ010000000
VERSION     DAVHIZ010000068.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 8185)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8185)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8185
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.070"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            47..1135
                     /gene="wecB"
                     /locus_tag="VVO18_001805"
     CDS             47..1135
                     /gene="wecB"
                     /locus_tag="VVO18_001805"
                     /EC_number="5.1.3.14"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000723326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-N-acetylglucosamine 2-epimerase
                     (non-hydrolyzing)"
                     /protein_id="HEU5586903.1"
                     /translation="MKKIMLVFGTRPEAIKMCSLVNELRKQEDMKTVVCVTGQHKEMV
                     SPVLDLFGVQPDYDLEIMKANQNLFSITISILEKIKPVLEKEQPDIVLVHGDTTTTYA
                     AALAAFYLGIKVGHVEAGLRTYNLQSPFPEEFNRQSTSIIANYHFAPTELAKENLIKE
                     GRNNIYVTGNTVIDALTTTVQKDYTHPDLDLNDGNRLILLTAHRRENLGEPMRHMFRA
                     VKRVLNEYDDVKVIYPIHKNPLVRETATEIFGDTERIQIIEPLDVLDFHNFMNHSYMI
                     LTDSGGVQEEAPSLGKPVLVMRDTTERPEGVAAGTLKLVGTDEETIYQNFKMLLDDPE
                     EYKKMSQASNPYGNGDASKQIVRILRGI"
     gene            1174..2043
                     /gene="rfbA"
                     /locus_tag="VVO18_001806"
     CDS             1174..2043
                     /gene="rfbA"
                     /locus_tag="VVO18_001806"
                     /EC_number="2.7.7.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000676139.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="HEU5586904.1"
                     /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLA
                     GIKDILIISTPQDLHRFQELLQDGSEFGLKLSYAEQPSPDGLAQAFIIGEEFISDDSV
                     ALILGDNIYHGSGLSKMLQKAASKESGATVFGYHVKDPERFGVVEFDQDMKAISIEEK
                     PEQPRSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRG
                     FAWLDTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLALAQPLKKN
                     EYGQYLLRLIGEA"
     gene            2044..2640
                     /locus_tag="VVO18_001807"
     CDS             2044..2640
                     /locus_tag="VVO18_001807"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000131470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase family
                     protein"
                     /protein_id="HEU5586905.1"
                     /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHRDNRGWFKENFQKEK
                     MLPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREG
                     ETFGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYA
                     DPSLGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDLE"
     gene            2650..3699
                     /gene="rfbB"
                     /locus_tag="VVO18_001808"
     CDS             2650..3699
                     /gene="rfbB"
                     /locus_tag="VVO18_001808"
                     /EC_number="4.2.1.46"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000141505.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="HEU5586906.1"
                     /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGN
                     RANIEEILGNRVELVVGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTN
                     FIGTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSP
                     YSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLY
                     GEGKNVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQAAD
                     AYDHVTDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKTEKE
                     AVEANYAKTQEIITV"
     gene            3765..4616
                     /gene="rfbD"
                     /locus_tag="VVO18_001809"
     CDS             3765..4616
                     /gene="rfbD"
                     /locus_tag="VVO18_001809"
                     /EC_number="1.1.1.133"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014713146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="HEU5586907.1"
                     /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDIIDAEMVEK
                     VFEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTD
                     YVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKN
                     FVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFITYLAENRKEFGYYHLSNDATEDT
                     TWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQE
                     FYKQEVR"
     gene            4679..5764
                     /gene="glf"
                     /locus_tag="VVO18_001810"
                     /pseudo
     CDS             4679..5764
                     /gene="glf"
                     /locus_tag="VVO18_001810"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000272499.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopyranose mutase"
     gene            6085..8067
                     /locus_tag="VVO18_001811"
     CDS             6085..8067
                     /locus_tag="VVO18_001811"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398389.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="HEU5586908.1"
                     /translation="MKSSKLFALAGVTLLAATTLAACSGSGSSTKGEKTFSYIYETDP
                     DNLNYLTTAKAATANITSNVVDGLLENDRYGNFVPSMAEDWSVSKDGLTYTYTIRKDA
                     KWYTSEGEEYAAVKAQDFVTGLKYAADKKSDALYLVQESIKGLDAYVKGEIKDFSQVG
                     IKALDDQTVQYTLNKPESFWNSKTTMGVLAPVNEEFLNSKGDDFAKATDPSSLLYNGP
                     YLLKSIVTKSSVEFAKNPNYWDKDNVHIDKVKLSFWDGQDTSKPAENFKDGSLTAARL
                     YPTSASFAELEKSMKDNIVYTQQDSITYLVGTNIDRQSYKYTSKTSDEQKASTKKALL
                     NKDFRQAIAFGFDRTAYASQLNGQTGASKILRNIFVPPTFVQADGKNFGDMVKEKLVT
                     YGDEWKDVNLADSQDGLYNPEKAKAEFAKAKSALQAEGVTFPIHLDMPVDQTATTKVQ
                     RVQSMKQSLEATLGADNVVIDIQQLQKDEVNNITYFAENAAGEDWDLSDNVGWGPDFA
                     DPSTYLDIIKPSVGESTKTYLGFDSGEDNVAAKKVGLYDYEKLVTEAGDETTDVAKRY
                     DKYAAAQAWLTDSALIIPTTSRTGRPILSKMVPFTIPFALSGNKGTSEPVLYKYLELQ
                     DKAVTVDEYQKAQEKWMKEKEESNKKAQEDLAKHVK"
BASE COUNT         2687 a         1388 c         1784 g         2326 t
ORIGIN      
        1 aatggtagat tacatttcta cctttttatc catttaggag gaaacgatga aaaagataat
       61 gctagttttc ggtacacgtc cagaagcaat aaaaatgtgt tcattagtca atgagttgag
      121 aaaacaggaa gatatgaaaa cagttgtttg tgtaactggt caacacaagg agatggttag
      181 ccctgtttta gatttatttg gagttcaacc agactatgat ttagaaatta tgaaggctaa
      241 tcaaaacttg ttctctataa caataagtat tttagaaaaa ataaaacctg tgttagaaaa
      301 agaacaacca gatattgttt tggttcacgg tgatactact acgacatatg cagcagcttt
      361 agcggcattt tatctaggaa ttaaagttgg tcatgttgaa gctggattac gaacttacaa
      421 cctgcaaagt cctttcccag aagagttcaa cagacaatcg acttctatta ttgcaaatta
      481 tcattttgct cctacagaat tagctaaaga aaatctaata aaagagggta gaaataatat
      541 ctatgttact ggaaatacag tgattgatgc acttacaact acagtacaaa aggattatac
      601 gcaccccgat ctagatttaa acgatggaaa tcgcctcatc ttattgactg ctcatagacg
      661 cgaaaatctc ggagaaccta tgagacatat gtttagagct gttaaacgag ttttaaatga
      721 atatgacgat gttaaagtaa tttatccaat tcataaaaat ccattggtac gggaaacagc
      781 tacagaaatt tttggagata cagaacgtat tcaaatcatt gaacctttag atgttcttga
      841 ttttcacaac tttatgaatc atagttatat gattctaact gactcaggag gggttcaaga
      901 agaggcacct tctttaggaa agcctgtatt ggtcatgcga gatacgacag aaagacctga
      961 aggagtagct gctggaacgt tgaaattggt tgggactgat gaggagacta tttatcaaaa
     1021 ctttaagatg cttttagacg atcccgaaga atataaaaaa atgagtcaag ctagtaatcc
     1081 ttatggaaat ggtgatgcta gtaaacagat tgttcgaatt ttacgtggaa tttgagtgtg
     1141 ttcagataaa gtaatataga aaggtaccct actatgaaag gtattattct agcaggtggt
     1201 tcggggacac gtttatatcc tttgactcgc gctgcatcaa aacaacttat gccggtttat
     1261 gataaaccga tgatttacta cccactttca acattgatgt tggctgggat taaggatatt
     1321 ttgattattt ccactccaca ggatttacat cgattccaag agcttcttca agacggatct
     1381 gagtttgggc tcaaactttc ttatgcagag caaccaagtc cagatggttt ggcacaagcc
     1441 tttatcattg gggaagagtt tatttctgat gatagcgttg cgctgatctt aggtgacaat
     1501 atctatcacg gttctgggct ttccaagatg ctacaaaagg cagcgagtaa ggagtcggga
     1561 gcaactgttt ttggctacca tgtcaaggat ccagagcgct ttggtgtggt tgagtttgat
     1621 caggatatga aggctatttc tattgaagaa aagccagagc aacctcgttc aaactatgca
     1681 gttacaggtc tctatttcta tgataatgat gtagtagaga ttgccaagag tattaaacca
     1741 agtcctcgtg gtgaactgga aattacagat gtaaacaagg cttacctaga tcgtggtgat
     1801 ttgtctgttg agcttatggg acgtggcttt gcttggctgg atactggaac tcatgaaagt
     1861 ttactagagg cttcacagta catcgaaaca gtgcaacgga tgcaaaatgt tcaggtagca
     1921 aacttagaag aaattgctta ccgtatgggc tatatcagtc gagaagatgt attggcctta
     1981 gcccaaccac ttaagaaaaa tgaatacgga cagtatctgc tccgtttgat tggagaagca
     2041 tagatgacag ataatttttt cggtaagacg cttgcggcac gcaaggttga agctattcca
     2101 ggcatgttgg agtttgatat ccccgttcat agagataatc gtggctggtt taaagaaaat
     2161 ttccaaaagg aaaaaatgct tccacttgga tttccagagt ctttctttgc agaaggaaaa
     2221 ttgcaaaaca atgtatcctt ctcacgtaaa aatgtccttc gaggtctcca cgcagagcct
     2281 tgggataagt acatctctgt agcagatgga gggaaagttc tgggttcttg ggttgatcta
     2341 cgcgagggtg aaacctttgg gaatacctat cagacagtga ttgatgcgag taagggaatc
     2401 tttgttcctc gaggcgtagc taatggcttc caagttttat cagatacagt gtcatatagc
     2461 tatctggtca atgattactg ggctcttgaa ctcaaaccca agtatgcctt tgtgaactac
     2521 gctgatccaa gccttggtat tgaatgggaa aatattgcag aagcagaggt ttcagaagca
     2581 gacaaacatc atccactact taaggatgta aaacctttga aaaaagaaga tttggaataa
     2641 ggaaagaata tgactgaata caaaaatatt atcgtgacag gtggagctgg ctttatcggt
     2701 tctaactttg tccattatgt ttacgagaac tttccagatg ttcatgtgac agtcctagat
     2761 aagttgactt atgctggaaa ccgcgcgaat attgaggaaa ttttaggtaa tcgtgttgag
     2821 ttagttgttg gtgacattgc tgatgcggag ttggtagaca agttggctgc tcaagcagat
     2881 gctatcgttc attatgcagc ggaaagccac aatgataatt cgctcaatga tccatcgcca
     2941 tttattcata ctaacttcat cggaacctat actcttttag aagctgctcg taagtatgat
     3001 attcgcttcc accatgtatc gacagatgaa gtttatgggg atctcccttt acgcgaagat
     3061 ttgccaggtc atggtgaagg accaggtgag aaatttactg ctgaaacaaa atacaaccca
     3121 agctctccgt actcatcaac caaggcagcc tcagatttga ttgtcaaagc ctgggtgcgt
     3181 tcttttggag tcaaggcaac gatttccaac tgttcaaata actacggtcc ttatcaacat
     3241 atcgaaaaat tcatcccacg tcagattact aacatcctaa gtggtatcaa gccaaaactt
     3301 tacggtgaag gtaagaacgt tcgtgattgg attcatacca atgaccattc ttcaggagtt
     3361 tggacaatct tgacaaaagg gcaaatcggt gaaacctact tgattggggc tgatggtgag
     3421 aagaacaata aggaagtttt ggaacttatc cttaaggaaa tgggacaagc tgcggatgcc
     3481 tatgatcatg tgactgaccg tgcaggacat gaccttcgct atgcgattga tgctagcaag
     3541 ctccgtgatg agttggggtg gaaacctgaa tttaccaact ttgaagctgg gctcaaggca
     3601 acaatcaagt ggtatacaga taaccaagaa tggtggaaaa cagagaaaga agctgttgaa
     3661 gccaattatg ctaagactca ggagattatt acagtataaa aagcaggaaa tagctgcttt
     3721 ttattgctat attgggaaga gttacatatt agaaaggtct agagatgatt ttaattacag
     3781 gggcaaatgg ccaattagga acggaacttc gctatttatt ggatgaacgt aatgaagaat
     3841 acgtggcagt agatgtggct gagatggaca ttatcgatgc agaaatggtt gagaaagttt
     3901 ttgaagaggt gaaaccgact ttagtctacc actgtgcagc ctacaccgct gttgatgcag
     3961 cagaggatga aggaaaagag ttggacttcg ccatcaatgt gacggggaca aaaaatgtcg
     4021 caaaagcatc tgaaaagcat ggtgcaactc tagtttatat ttctacggac tatgtctttg
     4081 acggtaagaa accagttgga caagagtggg aagttgatga ccgaccagat ccacagacag
     4141 aatatgggcg tactaagcgt atgggggaag agttagttga gaagcatgtg tctaatttct
     4201 atattatccg tactgcctgg gtatttggaa attatggcaa aaacttcgtt tttaccatgc
     4261 aaaatcttgc gaaaactcat aagactttaa cagttgtaaa tgaccagtac ggtcgtccga
     4321 cttggactcg taccttggct gagttcataa cctacctagc tgaaaatcgt aaggaatttg
     4381 gttattatca tttgtcaaat gatgcgacag aagacacaac atggtatgat tttgcagttg
     4441 aaattttgaa agatacagat gtcgaagtca agccagtaga ttccagtcaa tttccagcca
     4501 aagctaaacg tccgctaaac tcaacgatga gcctggccaa agccaaagct actggatttg
     4561 ttattccaac ttggcaagat gcattgcaag aattttacaa acaagaagtg agataagtag
     4621 tagaatgatt ttctagtcta ataaaagagg cagataatga actccaaagg agcttaagat
     4681 gtacgattat cttgttgtgg tgctggtctc tttggcgcag tctttgccca tgaagcagcc
     4741 ttaaaaggaa aaaaagtaaa agttattgaa aaacgaaatc atatcgcggg taatatctat
     4801 actcgtgaag aggaaggaat tcaagtttat caatatggtg ctcatatctt ccatacttct
     4861 gataaggaga tctgggatta tgtaaatcag tttgcagggt ttaaccgtta caccaattct
     4921 cctgttgcaa actataaggg tgagatttat aaccttcctt ttaatatgaa taccttcaat
     4981 aaactctggg gagttgtgac gccagcagaa gcacaagcta agattgatga acaacgtgct
     5041 attttaaatg gtaaaactcc tgaaaatttg gaagaacagg cgatttctct tgtaggtaca
     5101 gacatctacg aaaaattaat caaagactat acagagaaac agtggggcaa accaactact
     5161 gaacttccag cctttattat tgtttgccag tacgcctgac ctatgataac aactatttta
     5221 acgataccta tcaagggatt ccaattggtg gatacactca aatagttgaa aaatgttgga
     5281 tcatgaaaat attgatgtag aaacaaatgt tgatttcttt gtgaataaag agcaatatct
     5341 gaaagatttt cctaagattg tctttactgg tatgattgat gaattctttg actataagtt
     5401 gggcgaacta gagtaccgta gtcttcgttt tgaaaatgag accttggata tggaaaatta
     5461 ccaaggaaat gcagttgtga actatacgga tgcagaaatc ccatatactc gcattattga
     5521 acacaaacat tttgagtttg ggagtcaagc aaagactatc attactaaaa catgggaaaa
     5581 aggtgatgag ccttattatc cagttaataa tgatcgtaat aatcatttgt ataaatcgta
     5641 taaaaaactt gctgatgagc aagggaatgt tatctttggt ggccgcttag gacactatcg
     5701 ttattacgat atgcaccaag taattggagc agctttgcag tgcgtgagaa atgagttaga
     5761 ttaatactca atgaaaatca aagagcaaac taggaagcta gccacaggtt gctcaaaata
     5821 ctgttttgag gttgcagatg gaagctgacg cggtttgaag agattttcga agagtataaa
     5881 caagtaaaac tgactaccag ttattattta gaaatagtat taaaaattcc ttgactatgt
     5941 gatatagttg agggattttt aaatgatatt catatttttt gcaaagatgt tgtttgaaaa
     6001 ataattttca aaaattctga aaattctgtt gacatctttc tgaaaagagt ctataatgga
     6061 gagaaagttt taaaggagaa aatgatgaaa agttcaaaac tatttgccct tgcgggcgtg
     6121 acattattgg cggcgactac tttagctgca tgctctggat caggttcaag cactaaaggt
     6181 gagaagacat tctcatacat ttatgagaca gaccctgata acctcaacta tttgacaact
     6241 gctaaggctg cgacagcaaa tattaccagt aacgtggttg atggtttgct agaaaatgat
     6301 cgctacggga actttgtgcc gtctatggct gaggattggt ctgtatccaa ggatggattg
     6361 acttacactt atactatccg taaggatgca aaatggtata cttctgaagg tgaagaatac
     6421 gcggcagtca aagctcaaga ctttgtaaca ggactaaaat atgctgctga taaaaaatca
     6481 gatgctcttt accttgttca agaatcaatc aaagggttgg atgcctatgt aaaaggggaa
     6541 atcaaagatt tctcacaagt aggaattaag gctctggatg atcagacagt tcagtacact
     6601 ttgaacaaac ctgaaagttt ttggaactca aaaacaacca tgggtgtgct tgcgccagtt
     6661 aatgaagagt ttttgaactc aaaaggggat gattttgcca aagctacgga tccaagtagt
     6721 ctcttgtata atggacctta tttgttgaaa tccattgtga ccaaatcttc tgttgaattt
     6781 gcgaaaaatc cgaactactg ggataaggac aatgtgcata ttgacaaagt taaattgtca
     6841 ttctgggatg gtcaagatac cagcaaacct gcagaaaact ttaaagatgg tagccttaca
     6901 gcagctcgtc tctatccaac aagtgcaagt ttcgcagagc ttgagaagag tatgaaggac
     6961 aatattgtct atactcaaca agactctatt acgtatctag ttggtacaaa tattgaccgt
     7021 cagtcctata aatacacatc taagaccagc gacgaacaaa aggcatcgac taaaaaggct
     7081 ctcttaaaca aggatttccg tcaggctatt gcctttggtt ttgatcgtac agcctatgcc
     7141 tctcagttga atggacaaac tggagcaagc aaaatcttac gtaatatctt tgttccacca
     7201 acatttgttc aagcagatgg taaaaacttt ggcgatatgg tcaaagagaa attggttact
     7261 tatggggatg aatggaagga tgttaatctt gcagattctc aggatggtct ttacaatcca
     7321 gaaaaagcca aggctgaatt tgctaaagct aaatcagcct tacaagcaga aggtgtgaca
     7381 ttcccaattc atttggatat gccagttgac caaacagcaa ctacaaaagt tcagcgcgtc
     7441 caatctatga aacaatcctt ggaagcaact ttaggagcgg ataatgtagt cattgatatt
     7501 caacaactac aaaaagacga agtaaacaat attacatatt ttgctgaaaa tgctgctggc
     7561 gaagactggg atttatcaga taatgtcggt tggggtccag actttgccga tccatcaacc
     7621 taccttgata tcatcaaacc atctgtagga gaaagtacta aaacatattt agggtttgac
     7681 tcaggggaag ataatgtagc tgctaaaaaa gtaggtctat atgactacga aaaattggtt
     7741 actgaggctg gtgatgagac tacagatgtt gctaaacgct atgataaata cgctgcagcc
     7801 caagcttggt tgacagatag tgctttgatt attccaacta catctcgtac agggcgccca
     7861 atcttgtcta agatggtacc atttacaata ccatttgcat tgtcaggaaa taaaggtaca
     7921 agtgaaccag tcttgtataa atacttggaa cttcaagaca aggcagtcac tgtagatgaa
     7981 taccaaaaag ctcaggaaaa atggatgaaa gaaaaagaag agtctaataa aaaggctcaa
     8041 gaagatctcg caaaacatgt gaaataactg ttgcaaaata taagaaagga tttagtattt
     8101 ctcttgaatg ctgaatcctt ttttacattt gtaaagaaag attctaaatg tactgacccc
     8161 caaaagttgg agcctctttt tgtca
//
LOCUS       DAVHIZ010000069         7656 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.071, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000069 DAVHIZ010000000
VERSION     DAVHIZ010000069.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7656)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7656)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7656
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.071"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(112..276)
                     /locus_tag="VVO18_001812"
     CDS             complement(112..276)
                     /locus_tag="VVO18_001812"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586909.1"
                     /translation="MDESKYLCYLEKYDALGSGRLLAKVNNTYYMFNKNQIEFLRYSN
                     KNAKKERKYM"
     gene            complement(663..1523)
                     /locus_tag="VVO18_001813"
     CDS             complement(663..1523)
                     /locus_tag="VVO18_001813"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140341.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4299 domain-containing protein"
                     /protein_id="HEU5586910.1"
                     /translation="MAKTFFIPNKQSILGEQEILNAKSILALLDGLESHSYDVVYLRQ
                     PLNRLEYIECAIVGQSQFLFKVSYADGQKAYRVDLPDLLTKTDWQIIKSFLDALLAYT
                     GTDIEGLDGFDFEAYFQASIQAYLADPVARFTICQGIFNPIFFSRENLKSFLEADGLA
                     QFEARVRAVQETDAYFARVSFYQDGEGKVHGVYHLAQGVKTVLPREPFVPAAYIEQLV
                     DKEVQWEIDLVQITGDGSKPEDYESIARLDYAKFLEVLPPSFYHQLDANQIEVQPILD
                     KDFKTLAQEK"
     gene            complement(1798..2784)
                     /locus_tag="VVO18_001814"
     CDS             complement(1798..2784)
                     /locus_tag="VVO18_001814"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="rhodanese-related sulfurtransferase"
                     /protein_id="HEU5586911.1"
                     /translation="MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADE
                     GINGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEESEQAFKKMFVRYKKEIVHLGLE
                     DNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRN
                     FRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKD
                     PEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILT
                     SEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGESLDQAATV"
     gene            complement(3056..4531)
                     /locus_tag="VVO18_001815"
     CDS             complement(3056..4531)
                     /locus_tag="VVO18_001815"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000800432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3502 domain-containing protein"
                     /protein_id="HEU5586912.1"
                     /translation="MKNWKKYAFASASVVALAAGLAACGNLTGNSKKAADSGDKPVIK
                     MYQIGDKPDNLDELLANANKIIEEKVGAKLDIQYLGWGDYGKKMSVITSSGENYDIAF
                     ADNYIVNAQKGAYADLTELYKKEGKDLYKALDPAYIKGNTVNGKIYAVPVAANVASSQ
                     NFAFNGTLLAKYGIDISGVTSYETLEPVLKQIKEKAPDVVPFAIGKVFIPSDNFDYPV
                     ANGLPFVIDLEGDTTKVVNRYEVPRFKEHLKTLHKFYEAGYIPKDVATSDTSFDLQQD
                     TWFVREETVGPADYGNSLLSRVANKDIQIKPITNFIKKNQTTQVANFVISNNSKNKEK
                     SMEILNLLNTNPELLNGLVYGPEGKNWEKIEGKENRVRVLDGYKGNTHMGGWNTGNNW
                     ILYINENVTDQQIENSKKELAEAKESPALGFIFNTDNVKSEISAIANTMQQFDTAINT
                     GTVDPDKAIPELMEKLKSEGAYEKVLNEMQKQYDEFLKNKK"
     gene            complement(4789..5712)
                     /locus_tag="VVO18_001816"
     CDS             complement(4789..5712)
                     /locus_tag="VVO18_001816"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001075101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="HEU5586913.1"
                     /translation="MAKKKIKKEKIDNVGIHSFSKKADIFFSIISGLIALSCILPFVF
                     VIIISVTDEKSLLQYGYSFFPSQFGLDGFEFLAQFKDKILQALFISVFVTVVGTLTNV
                     FITTTYAYAISRTTFKYRRFFTIFVLLSMLFNAGLVPGYIMVTRVLQLGDTVWALIVP
                     MLLSPFNIILMRSFFKKTIPEAILESARIDGASEARIFFQICLPLSLPGIATITLLTA
                     LGFWNDWFNALLYIKSDNLYPLQYLLMQIQQNMDYIAKAVGLTGQLGVALPKETGRMA
                     MVVVATLPIAILYPFFQRYFVKGLTIGGVKE"
     gene            complement(5726..6655)
                     /locus_tag="VVO18_001817"
     CDS             complement(5726..6655)
                     /locus_tag="VVO18_001817"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000714575.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar ABC transporter permease"
                     /protein_id="HEU5586914.1"
                     /translation="MKKFSKTLRDNWIFLLMVLPGALWLILFFYIPVFGNVVAFKDYH
                     MTSNGFIDSIINSKWVGLDNFRFLFSSRDAFIITRNTVLYNLGFIFLGLVVSVGIAII
                     LSELRSKRMVKIFQTSMLFPYFLSWVIISFFTDAFLNIDKGVFNHLLESLGLKEVNFY
                     ADLGIWPYLLLFLGIWKGFGYSSVMYYATIMGIDPTYYEAATVDGASKWQRIRNVTIP
                     QLTPLVTVLTILAVGNIFRADFGLFYQIPHNAGQLYNVTNVLDVYVFNGLTQTADIGM
                     AAAAGLYQSVVGLILVILSNLLARRVDPNSALF"
     gene            complement(6974..7195)
                     /locus_tag="VVO18_001818"
     CDS             complement(6974..7195)
                     /locus_tag="VVO18_001818"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001809441.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586915.1"
                     /translation="MSLQIKLKKLAKELSKLLKDSNLETVDKDVLENSQKELQKAVLF
                     LADEKGSEHTEAEVIDNLKEVIAKLKANA"
     gene            complement(7149..7409)
                     /locus_tag="VVO18_001819"
     CDS             complement(7149..7409)
                     /locus_tag="VVO18_001819"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001810173.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586916.1"
                     /translation="MTGVSNPTTDSARLVLAEAKKAFADDSLTEQGLRDILQTVKDAI
                     ASLESIKESQSATKDGGQTAGKETAGEDESANQTQEISQGIK"
BASE COUNT         2299 a         1524 c         1438 g         2395 t
ORIGIN      
        1 acaaaaactt caacccatta tcatcaaatg aatttttctt aacaagtatt ccttgtttgt
       61 aaaaataatc aataaattgg tctatggtat tactagtata gcaggaaaac tttacatata
      121 tttcctctct tttttagcat ttttatttga gtatcgtaag aattcaatct gatttttgtt
      181 aaacatatag taagtattat taactttagc taataatcgt cctgagccta aagcatcata
      241 tttttcaaga tagcacaaat attttgattc atccatccta aattatctcc acatcaaatt
      301 ctgtgcattc tcgtttgaca tcagcggact cctcctataa aattacgatt agattgcata
      361 tatctagtga ttgtcgagtt aatgaaatta ttgtatacta tattcaaaat attgtcaaca
      421 aaaaaaatag aaaattttct gataatttgt gattaaaacc aataccatac ctctcccatc
      481 attgaaaagc gcagtcatta cttaaaaagt cactcgttta tgttataata ggctccataa
      541 tatccatagg ggatttaccc actacaaata ttatagagcc gattttcatt gagtagcaat
      601 cctgtcatcc ttggcaggat ttttctattt caaaaaagca agtcgattga cctgcttctg
      661 ctttactttt cttgtgctaa tgttttaaaa tctttgtcta atatgggttg cacttctatt
      721 tgattggcgt ctagttggtg gtaaaaagat gggggtaata cctctaagaa ttttgcatag
      781 tccaagcgag ctatggattc atagtcttct ggtttagagc cgtctcctgt gatttgaacc
      841 aagtcaatct cccactggac ttccttatcc accaattgct caatataggc tgcaggaaca
      901 aacggttctc tcggtaaaac tgtcttgact ccttgagcta gatggtaaac gccatgcact
      961 tttccttctc catcctgata gaaggaaact ctcgcaaagt aggcatctgt ctcttgaacc
     1021 gcacgcacac gcgcttcaaa ctgagccaag ccatctgcct ctaaaaagct tttcaagttc
     1081 tcacgactaa agaaaatagg attaaaaatt ccttggcaaa tcgtaaaacg agctacaggg
     1141 tctgctagat aggcttgaat acttgcttgg aaataagctt caaaatcaaa accatctagc
     1201 ccttcaatat cagtccctgt ataagcaagc aaagcatcta aaaatgactt gataatctgc
     1261 cagtctgtct ttgttagtag gtcaggaaga tcgacacggt aagccttttg accatcagca
     1321 taactgacct taaagagaaa ttgtgattgc cccactatcg cacactcaat atactcgaga
     1381 cgattaagag gctgacggag atagactaca tcatagctat gtgactccaa accgtctagc
     1441 aaggccaaga tcgacttggc attcaaaatc tcttgttctc ctaaaatgct ctgtttattt
     1501 ggaataaaaa atgttttcgc cataactgga ctcctttgaa atcgtttaca tacagtatac
     1561 cttatttttc tgaaagatac aaaaacaaac tttatattct tcgaaaatct cttcaaaccg
     1621 cgtcagcttc gccttgccgt agatatatgt aactgacttc gtcagtctta tctacaacct
     1681 caaagcagtg ctttgagcag cctgcggcta gcttcctagt ttgctctttg attttcattg
     1741 agtattagat ttttgagtac aaagcataga aaaacagccc ctaaggactg tttgatctta
     1801 tacagtagct gcctgatcca agctttcacc gatagcggct aggcgctcaa tcacttcagc
     1861 ttgtgtcaat tcattttttg aaacatagcg gttacgtggg tgaacacggc actcgtgtga
     1921 gcatccacga aggtacttgt cttcattttc ttctgatgtc aagatacgac ggttacagaa
     1981 gggatttcca cagttgacat aacgttcaca tggtgttcca tcaaaccagt ctttccctac
     2041 gatggttggg ttgacatggt tgacatcaac ggcaatacgc tcgtcaaaga cgtacatttt
     2101 cccatcccaa agctcacctt gaacttctgg gtctttaccg taagttgcga ttcctccgtg
     2161 caattggcca acatctttgt aaccttcacg aaccatccag cctgagaatt tctcacagcg
     2221 aacaccacct gtacagtaaa ccacgacacg cttgtccatg aatttttctt tgttgtcacg
     2281 gacccattgt ggtaactcac ggaagttgcg aatatctggg cgaatagccc cacggaaatg
     2341 tcctaggtcg tactcataat cgttacgtgt gtcaaggaca acggtatctt tatcaagaag
     2401 cgcttctttg aactcttttg gagacaagta agcacctgtt gtttcaagtg ggttgatgtc
     2461 attgtcaaag tcgttgtctt ccaaaccaag gtggacaatt tctttcttgt agcgaacaaa
     2521 catcttcttg aaggcttgtt cactttcttc gtcaatcttg aaccagagat cttccattcc
     2581 tggaaggctg tgaacgtagt ccatgtattt ttgagttgtt tcatagtcac ctgaaactgt
     2641 tccgttaatt ccctcgtcag cgactaggat acggccttta aggccgattg atttacagaa
     2701 agccaagtgg tctgcagcaa attgctctgc attttcaatt ggagtataaa ggtagtaaag
     2761 taagacacga atatcttttg ccataagatt tgttctcttt tctattctta aattttctaa
     2821 attttttatt tatccatact agtatacctg cttgagaaaa cgaatgcaat ttatttgact
     2881 ggaaattgta gaggattctc gaaatttcct gaatggttaa aataaggaca agagaaaaca
     2941 tggatatcta tatccttgtg ccaaaaaaac cactgccctc cccagaccaa cctgaggaaa
     3001 gcagtgattc ttattttagg agttaggaat gaatacacga aatcaattta gctgattatt
     3061 ttttgttttt caagaattca tcgtattgtt tttgcatttc gttcaatact ttttcgtagg
     3121 caccttcaga tttcaatttt tccatcaatt ctggaatagc tttatctggg tctacagtac
     3181 cagtgttgat agctgtatca aattgttgca ttgtgttagc aatagctgag atttcagatt
     3241 tcacattgtc agtattgaag ataaatccaa gcgctggaga ttctttagct tctgccaatt
     3301 ctttcttaga attttcgatt tgttggtctg taacgttttc gttgatgtaa aggatccagt
     3361 tgttaccagt gttccatcca cccatgtgag tgtttccttt gtagccatca agaacgcgaa
     3421 cacggttttc tttaccttca attttttccc agttcttgcc ttctggaccg taaacaagac
     3481 cgttcaagag ttctggattc gtattcaaga ggttcaagat ttccattgat ttttctttgt
     3541 tcttagagtt gtttgagatg acaaagttag caacttgtgt tgtttggttt ttcttgatga
     3601 agttagtaat tggtttgatt tggatatctt tgttggcaac acgtgaaagc aagctgttac
     3661 cgtagtcagc tggtcctact gtttcttcac gaacgaacca agtatcttgt tgaaggtcaa
     3721 aggaagtatc gcttgttgcg acgtcttttg gaatgtagcc agcttcatag aatttgtgaa
     3781 gagtcttcaa gtgttctttg aaacgaggca cttcgtaacg gtttacaact ttagtagtat
     3841 cgccttcaag gtcgataacg aatggaagac cgtttgctac tgggtagtca aagttatcag
     3901 atgggatgaa aactttacca atagcaaatg gtactacgtc tggagctttt tctttaattt
     3961 gtttcaagac tggctcaaga gtttcgtaag aagtaacacc tgaaatatcg ataccatatt
     4021 tagcaaggag agttccgttg aaggcaaagt tttgagatga tgcaacgttg gctgcaactg
     4081 gaacagcgta aatcttacca tttacagtat tacccttgat gtaagctggg tcaagtgctt
     4141 tgtaaaggtc tttaccttct tttttgtaca attctgtcaa gtcagcgtaa gcaccttttt
     4201 gagcatttac aatatagtta tctgcaaagg caatatcata gttttcacca gatgatgtga
     4261 taactgacat tttcttacca tagtcacccc agccaaggta ttggatatcc aatttggcac
     4321 caactttttc ttcaatgatt ttgttggcat ttgctaacaa ttcatccaag ttgtctggtt
     4381 tgtcaccgat ttggtacatt ttgataacag gtttgtcacc tgaatcagca gcttttttgc
     4441 tgttacctgt caaatttcca caagcagcaa gacctgcagc caaagcgact acactagcag
     4501 atgcaaaagc atattttttc cagtttttca tgataaaaac tccttttttt atttttaaac
     4561 ttataaacaa tgtaatgatc ttatactcaa tgaaaatcaa agagcaaact agaaaactag
     4621 ccgcaggctg ctcaaagcac tgctttgagg ttgtagataa gactgacgaa gtcagttaca
     4681 tatatctacg gcaaggcgac gttgacgcgg tttgaatttg attttcgaag agtattaact
     4741 tcacacaagg gaagttggga actgagaaat gttctttttc aataagcact attctttcac
     4801 accaccgata gtcaaacctt ttacaaagta gcgttggaag aatggatata aaatcgcgat
     4861 tggaagggtt gcaaccacaa ccatggccat acgacctgtt tctttcggta gagcaactcc
     4921 cagttgacca gtcaagccga ccgctttggc aatgtagtcc atattttgtt ggatttgcat
     4981 gagcaaatat tgcaatggat acaagttatc actcttgatg taaagaaggg cgttgaacca
     5041 gtcattccag aaaccaagag ctgtcaaaag cgtgatggtt gcgatacctg gtagtgacaa
     5101 tggcaaacag atttggaaga aaatccgggc ctcactggca ccatcgatac gagccgattc
     5161 gagaatggct tctggaatgg tcttcttgaa gaaggaacgc atcaagatga tattgaatgg
     5221 tgagagaagc attggaacaa tcaaggccca aacagtgtca ccaagctgaa gtacacgggt
     5281 caccatgata taacctggta ccaaaccagc gttgaacaac atactgagaa ggacgaagat
     5341 ggtaaaaaat ctgcgatact taaaggttgt ccgtgaaata gcgtaggcat aggttgttgt
     5401 gataaagaca tttgtcaatg tcccaactac ggttacaaag acagagatga agagggcttg
     5461 taggatttta tccttaaact gtgccaaaaa ctcaaaaccg tctaagccaa attgggatgg
     5521 gaagaagcta tagccgtatt ggaggaggct tttctcgtct gtcactgaaa taatgataac
     5581 gaatacaaaa ggtaggatac aagagagggc aatcaaaccc gaaatgatac tgaagaagat
     5641 atctgctttc ttactgaagg agtgaatgcc gacattatca attttttctt ttttaatttt
     5701 cttttttgcc atattctcct cctttctaga acaaagctga gtttggatcg actcgtcttg
     5761 caagcaagtt tgataggata accagaatca aaccaacaac ggattggtaa agaccggctg
     5821 ctgcagccat accgatatct gctgtctgag tcaaaccatt aaaaacatat acgtccaaaa
     5881 cgttggttac attgtaaagc tgaccagcat tgtgtgggat ttgatagaag agaccgaagt
     5941 ctgcgcggaa gatatttccg actgcaagga tggtcaatac agttacaagc ggagtcaact
     6001 gaggaatggt tacgttgcga atacgttgcc acttgctagc tccgtccact gtcgctgctt
     6061 cgtagtaggt tggatcaatt cccatgatcg tcgcatagta catgacactg ctatatccaa
     6121 aacctttcca aatacctagg aaaagtagga gatagggcca gatgcccagg tcagcgtaga
     6181 aattgacttc tttgagacca agactttcca atagatgatt gaacacccct ttatcaatat
     6241 ttaggaaggc atctgtaaag aaactgatga taacccaaga caagaagtaa gggaacaaca
     6301 tagaagtttg gaaaatcttc accattctct tagaacggag ctcgctgagg ataatggcaa
     6361 tccctacaga tacaactaaa cctagaaaga taaagccaag attgtagagg acagtatttc
     6421 gtgtgataat aaaggcgtct cttgaactaa ataagaatct gaaattatcg agtccgaccc
     6481 atttactatt tatgatacta tctatgaaac cattactggt catgtggtag tctttgaagg
     6541 caaccacgtt cccaaatact ggaatgtaaa agaatagaat caaccagagt gcccctggca
     6601 aaaccatcaa gagaaagatc cagttgtctc tcaatgtttt tgaaaacttt ttcataattt
     6661 cctccctttt tattttgata tccatctaaa aattcttttt tagacttttg ataacgatta
     6721 cattattagt atactcctat ttgcaggtta ggttaaactc ctaattatag aaaaaactcc
     6781 acaaattatg tagcagattt aaaactttat caccactatc aaacaaatgt cctaaatcaa
     6841 ttgtttattt tatctctatt agcccagtga tggcgtcact ctgttataag catccaacaa
     6901 cggggtatac tgaaaaatct ccagactagg gaactcagag atagttccta atctggagat
     6961 ttttaatatg ttattaggcg tttgctttca acttagcaat aacctcttta agattatcaa
     7021 tcacctctgc ttcagtatgc tcagagcctt tttcatctgc caagaacaaa actgcttttt
     7081 gaagttcttt ttgagagttt tcaaggacat ccttatctac tgtttcaagg tttgagtctt
     7141 taagaagttt acttaattcc ttggctaatt tcttgagttt gatttgcaga ctcatcttct
     7201 cctgctgttt ctttgcccgc tgtttgtcct ccatccttag ttgctgactg gctttcctta
     7261 atggactcta gggaagcaat ggcatctttg actgtttgca agatatcacg taaaccttgc
     7321 tctgtcaaac tatcatctgc aaaagctttc ttagcctctg ccaaaaccag acgtgctgaa
     7381 tctgtggtag gattcgatac acctgtcaat gatctcaaaa gattttctaa ggtttgagtc
     7441 tgcttactaa tactagacta aaatcaaaaa gcattatata acagtgatat gaaatcaact
     7501 aaagaagaaa tccaaaccat caaaacactt ttaaaagact ctcgtacagc taaatatcat
     7561 aaacgccttc aaatcgttct atagtaaaat gaaacaagaa cagggtaaat cgatcaggac
     7621 agtcaaatcg atttctaaca atgttttaga agtaga
//
LOCUS       DAVHIZ010000070         7267 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.072, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000070 DAVHIZ010000000
VERSION     DAVHIZ010000070.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7267)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7267)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7267
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.072"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            1..510
                     /locus_tag="VVO18_001820"
                     /pseudo
     CDS             1..510
                     /locus_tag="VVO18_001820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="internal stop; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            571..1533
                     /locus_tag="VVO18_001821"
     CDS             571..1533
                     /locus_tag="VVO18_001821"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /protein_id="HEU5586917.1"
                     /translation="MNMSNITIDGQEMDLSQTMPSYAQVVSLYDDTSISVSNNETDKV
                     LAGSLYTDTNEQGLTIPSSLLKNWNEQTGKNLTANDLIGKSVSASIVESAAETSKIAQ
                     FQTKIVRVINDEDDMEDSNSFMLSHQMETISKEAGFTKAVSYFILELKDPSQTKVVTE
                     ELQKNKKYTVLSQQRVLDIVITFIRVIQGLLIVLSSQAIVVAAVMIGIIIYINIMQRS
                     KEIGVMKAVGYQNRDVKGIFIYEAIWIVGIALLLAFLVAQGVGSLANAIVSHFYPSIA
                     KVFELNLLSVLGTLVFALLLGYVSAYFPARKISKMDPVESLRYE"
     gene            1713..2720
                     /gene="gap"
                     /locus_tag="VVO18_001822"
     CDS             1713..2720
                     /gene="gap"
                     /locus_tag="VVO18_001822"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008090210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="HEU5586918.1"
                     /translation="MVVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPVMLAHL
                     LKYDTTQGRFDGTVEVKEGGFEVNGKFVKVSAERDPEQIDWATDGVEIVLEATGFFAK
                     KEAAEKHLKGGAKKVVITAPGGNDVKTVVFNTNHDVLDGTETVISGASCTTNCLAPMA
                     KALQDNFGVVEGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIG
                     LVIPELNGKLDGSAQRVPTPTGSVTELVAVLEKNVTVDEVNAAMKAASNESYGYTEDP
                     IVSSDIVGMSYGSLFDATQTKVLDVDGKQLVKVVSWYDNEMSYTAQLVRTLEYFAKIA
                     K"
     gene            complement(2789..3625)
                     /locus_tag="VVO18_001823"
     CDS             complement(2789..3625)
                     /locus_tag="VVO18_001823"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000216776.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RluA family pseudouridine synthase"
                     /protein_id="HEU5586919.1"
                     /translation="MTVKQLLEEQLLIPRKIRHFLRIKKHILINQEEVHWNEIVNPGD
                     VCQLTFDEEDYSQKTIPWGNPDLVQEVYQDQHLIIVNKPEGMKTHGNQPNEIALLNHV
                     STYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLEKKEISREYWALVDGNINRK
                     ELVFRDKIGRDRHDRRKRIVDAKNGQYAETYVSRLKQFSNKTSLAHCKLKTGRTHQIR
                     VHLSHHNFPILGDPLYNSNSKTSRLMLHAFRLSFTHPLTLEKLNFTALSNTFETELKK
                     NG"
     gene            3751..5946
                     /locus_tag="VVO18_001824"
     CDS             3751..5946
                     /locus_tag="VVO18_001824"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000762602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="penicillin-binding protein"
                     /protein_id="HEU5586920.1"
                     /translation="MKLDKLFEKFLSLFKKETSELEDSDSTILRRSRSDRKKLAQVGP
                     IRKFWRRYHLTKIILILGLSAGLLVGIYLFAVAKSTNVNDLQNALKTRTLIFDREEKE
                     AGALSGQKGTYVELTDISKNLQNAVIATEDRSFYKNDGINYGRFFLAIVTAGRSGGGS
                     TITQQLAKNAYLSQDQTVERKAKEFFLALELSKKYSKEQILTMYLNNAYFGNGVWGVE
                     DASKKYFGVSASEVSLDQAATLAGMLKGPELYNPLNSVEDSTNRRDTVLQNMVAAGYI
                     DKNQETEAAEVDMTSQLHDKYEGKISDYRYPSYFDAVVNEAVSKYNLTEEEIVNNGYR
                     IYTELDQNYQANMQIVYENISLFPRAEDGTFAQSGSVALEPKTGGVRGVVGQVADNDK
                     TGFRNFNYATQSKRSPGSTIKPLVVYTPAVEAGWALNKQLDNHTMQYDSYKVDNYAGI
                     KTSREVPMYQALAESLNLPAVATVNDLGVDKAFEAGEKFGLNMEKVDRVLGVALGSGV
                     ETNPLQMAQAYAAFANEGLMPEAHFISRIENASGQVIASHKNSQKRVIDKSVADKMTS
                     MMLGTFTNGTGISSSPADYIMAGKTGTTEAVFNPEYTSDQWVIGYTPDVVISHWLGFP
                     TTDENHYLAGSTSNGAAHVFRNIANTILPYTSGSTFTVENAYKQNGIAPANTKRQVQT
                     NDNSQTDDNLSDIRGRAQSLVDEASRAISDAKIKEKAQTIWDSIVNLFR"
     gene            5999..6151
                     /gene="rpmG"
                     /locus_tag="VVO18_001825"
     CDS             5999..6151
                     /gene="rpmG"
                     /locus_tag="VVO18_001825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015912025.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L33"
                     /protein_id="HEU5586921.1"
                     /translation="MALKKASLACAVCGSRNYSIKISGNPKPTRLEVNKFCKHCGKYT
                     THRETR"
     gene            6161..6337
                     /gene="secE"
                     /locus_tag="VVO18_001826"
     CDS             6161..6337
                     /gene="secE"
                     /locus_tag="VVO18_001826"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001211016.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="preprotein translocase subunit SecE"
                     /protein_id="HEU5586922.1"
                     /translation="MRFIGDIFRLLKDTTWPTRKESWRDFRSIMEYTAFFVVIIYIFD
                     QLIVSGLIRFINIF"
     gene            6392..6928
                     /gene="nusG"
                     /locus_tag="VVO18_001827"
     CDS             6392..6928
                     /gene="nusG"
                     /locus_tag="VVO18_001827"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376740.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription termination/antitermination
                     protein NusG"
                     /protein_id="HEU5586923.1"
                     /translation="MDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIP
                     TQTVQVEKNGKRKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPT
                     PLLEQEIRDILVSMGQTVQEFDFDVEIGQTVRIIDGAFADYTGKITEIDNNKVKMIIS
                     MFGNDTVAEVNLNQIAEL"
     gene            7050..>7267
                     /locus_tag="VVO18_001828"
     CDS             7050..>7267
                     /locus_tag="VVO18_001828"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588894.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU5586924.1"
                     /translation="MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISR
                     EEGLVDDIPRLRKYFKTKFRNRILDYIR"
BASE COUNT         2280 a         1256 c         1570 g         2161 t
ORIGIN      
        1 ccagaaaaag tagccttatt tcttaaaaat tttaatagtt taaagcacct agcacctgtt
       61 tagattgatg aaacaggatt cgatacttat ttttatcgag aatatggtcg ctcattaaaa
      121 ggtcagttaa gaagaggtaa agtatctgga agaagatatc agaggatttc tttggttgca
      181 ggtctaacaa atggtgagtt aatcgctcca atgacttacg aagagatgat gacgagcgac
      241 ttttttgaag cttggtttca gaagtttctc ttaccaacat taaccacacc atcggttatt
      301 attatggata atgcaagatt ccatagaatg ggtaagttag aacttttatg cgaggagttt
      361 gggcataaac ttttacctct tcctccctac tcacctgagt acaatcctat tgagaaaaca
      421 tgggctcata tcaaaaagca cctcaaaaag gtattaccaa gttgcaatac cttttacgag
      481 gcttttttat cctgctcttg tttcaattga ctatagttca cggatacagt tgggaaagaa
      541 gctattaaat atttggagag tccttttggg atgaacatgt caaatattac tatagatggg
      601 caagaaatgg atctgagtca aacgatgcct tcttatgctc aagtagtgag tctttatgat
      661 gatacaagta tctctgttag taataatgag acggacaaag tgttggctgg ctccctctat
      721 actgatacaa atgaacaggg attaacgatt ccaagcagtt tactaaaaaa ttggaatgaa
      781 cagacaggaa aaaatttgac agctaatgat cttattggca aatcagtctc agccagcatt
      841 gtagaaagtg ctgccgaaac tagtaagatt gctcaatttc aaacgaagat tgtacgtgta
      901 atcaatgatg aagatgacat ggaggacagc aacagtttca tgctgtctca tcaaatggaa
      961 acgatttcga aagaggctgg atttacgaaa gctgtatctt attttatctt ggaactcaaa
     1021 gatccatcac agacaaaagt agtaacagaa gaattacaga aaaataagaa gtatactgtg
     1081 ctttctcaac agagagttct tgatattgtg attaccttta ttcgtgttat tcagggatta
     1141 ttgattgtgc tttcatcaca agctattgtg gtagcagcgg ttatgattgg tatcattatt
     1201 tacatcaata tcatgcaacg ttccaaggaa ataggtgtca tgaaggcagt tggctatcag
     1261 aatcgtgatg tcaaaggaat ttttatttac gaggctatct ggattgtagg aatcgccttg
     1321 ctactggctt ttttggtagc acaaggggtg ggaagtttag cgaatgcgat tgtaagtcac
     1381 ttttacccat ccatcgctaa ggtctttgaa ttaaatttgt tatctgtttt aggaactcta
     1441 gttttcgctc tcttgcttgg ctatgtatca gcctacttcc cagcacgtaa aattagtaaa
     1501 atggaccctg tagaatcgct acgctatgaa tagtcaaggg tgttactaga ttatcgtccc
     1561 taaaaaagaa actaacagag aaaaacaatg cccgtacttg caattcaact caaatagtta
     1621 tataataggt ttgttgaaag gtgatttgta gtgattcaag ttactctttt cacaataaaa
     1681 atttcatgat tttcataagg aggaaatcac taatggtagt taaagttggt attaacggtt
     1741 tcggacgtat cggtcgtctt gctttccgtc gtatccaaaa cgtagaaggt gttgaagtta
     1801 cacgcatcaa cgaccttaca gatccagtta tgcttgcaca cttgttgaaa tacgacacaa
     1861 ctcaaggtcg tttcgacggt actgttgaag ttaaagaagg tggattcgaa gttaacggta
     1921 aattcgttaa agtttctgct gaacgtgatc cagagcaaat cgactgggct actgacggtg
     1981 tagaaatcgt tcttgaagct actggtttct ttgctaagaa agaagcagct gaaaaacacc
     2041 ttaaaggtgg agctaaaaaa gttgttatca ctgctcctgg tggaaacgac gttaaaacag
     2101 ttgtattcaa cactaaccac gacgttcttg acggtactga aacagttatc tcaggtgctt
     2161 catgtactac aaactgcttg gctccaatgg ctaaagctct tcaagataac tttggtgttg
     2221 ttgaaggatt gatgactact atccacgctt acactggtga ccaaatgatc cttgacggac
     2281 cacaccgtgg tggtgacctt cgccgtgctc gcgctggtgc tgcaaacatc gttcctaact
     2341 caactggtgc tgctaaagct atcggtcttg taatcccaga attgaacggt aaacttgacg
     2401 gatctgcaca acgcgttcca actccaactg gatcagttac tgaattggta gcagttcttg
     2461 aaaagaacgt tactgttgat gaagtgaacg cagctatgaa agcagcttca aacgaatcat
     2521 acggttacac agaagatcca atcgtatctt cagatatcgt aggtatgtct tacggttcat
     2581 tgtttgacgc aactcaaact aaagttcttg acgttgacgg taaacaattg gttaaagttg
     2641 tatcatggta cgacaacgaa atgtcataca ctgcacaact tgttcgtact cttgaatact
     2701 tcgcaaaaat tgctaaataa ttcttgaatc gataaaaagc aaggcctctt ggtcttgctt
     2761 ttcttatatg gaaaaatgga tgacacaatc atccattctt ttttaattct gtttcaaaag
     2821 tatttgagag ggcagtgaag tttaattttt ctaatgtaag tggatgggta aaggaaagtc
     2881 gaaaggcatg aagcataagc cgacttgtct ttgaattgct gttatagaga gggtcgccca
     2941 aaatagggaa gttatgatgc gaaaggtgca cacgaatctg atgggttcgc cctgtcttta
     3001 gcttgcaatg agccaaggaa gtcttgtttg agaattgctt taatctgctt acatacgttt
     3061 cagcatattg cccatttttt gcatcaacta ttctttttct acgatcatgg cgatcacgtc
     3121 caattttgtc tctgaaaaca agttcttttc tgttgatatt tccatcaact agagcccaat
     3181 attctctaga aatctctttt ttctccaata agcgattgag aatgggcagg ataaaaggat
     3241 ttttggcaaa gagaactaag ccactggttt ccatgtccag acgatgaacg acatagcagg
     3301 tttggccaac ataggtactg acatggttaa gaagggcaat ttcgtttggt tgattaccat
     3361 gcgttttcat cccctctggt ttgtttacaa taatcaagtg ttgatcttga taaacttcct
     3421 gcactaagtc tgggttgccc caagggatcg tcttttggga ataatcttcc tcgtcaaaag
     3481 tcaactggca aacatctcca ggatttacga tttcgttcca gtggacttct tcttgattta
     3541 tcaaaatatg tttcttgatt ctcaaaaaat gacggatttt tctagggatg aggagttgtt
     3601 cctcaagtaa ttgctttacc gtcatttgag gtagagaggc gggtaatgta aatgtgaatt
     3661 gcatacagat attgtaacaa aaaaagccct atttggatag gaaatagcta aattcttgtc
     3721 ttcctatgat gaagatgata aaataaacgc atgaaattag ataaattatt tgagaaattt
     3781 ctttctcttt ttaaaaaaga aacaagtgaa ctagaggact ctgattctac tatcttacgt
     3841 cgctctcgta gtgatcgaaa aaaattagcc caagtaggtc cgattcgaaa attctggcgt
     3901 cgttatcatc taacaaagat tatccttata ctaggtttga gtgcaggatt gctagttgga
     3961 atctatttgt ttgctgtagc caagtcgacc aatgtcaatg atttgcaaaa tgccttgaaa
     4021 actcggactc ttatttttga ccgtgaagaa aaagaggctg gtgccttgtc tggtcaaaag
     4081 ggaacctatg ttgagctgac tgacatcagt aaaaacttgc agaatgctgt tattgcgaca
     4141 gaagaccgtt ctttctataa aaatgacggg attaactatg gccgtttctt cttggctatt
     4201 gtcactgctg gacgttcagg tggtggctct accattaccc aacagctggc taaaaacgcc
     4261 tatttatcgc aggatcaaac tgttgagaga aaagcgaaag aatttttcct tgccttagaa
     4321 ttaagcaaaa aatatagtaa ggagcaaatt ctaaccatgt accttaacaa cgcttatttt
     4381 ggaaatggtg tgtggggtgt agaagatgcg agtaagaaat actttggagt ttctgcatca
     4441 gaagtgagtc tggatcaagc tgcgactctg gcagggatgc tcaaggggcc ggaactgtat
     4501 aatcccttga attctgtaga agattctact aatcggcgcg atactgtctt gcagaatatg
     4561 gttgcagcag gatatattga taaaaaccaa gaaaccgaag ctgctgaagt tgatatgact
     4621 tcgcaattgc acgataagta tgaaggaaaa atctcagatt accgttaccc ctcttatttt
     4681 gatgcggtgg ttaatgaagc tgtttccaag tataatctaa cagaggaaga gattgtcaat
     4741 aatggctacc gcatttacac agagctggac caaaactacc aagcaaatat gcagattgtt
     4801 tatgaaaaca tatcgctatt tccgagggca gaggatggaa cgtttgctca atcaggaagt
     4861 gtagctctcg aaccgaaaac agggggagtt cgtggagttg tcggtcaagt tgctgacaat
     4921 gataaaactg gattccggaa tttcaactat gcaacccaat caaagcgtag tcctggttct
     4981 acaattaagc ctttagttgt ttatacgcca gcagttgaag caggctgggc tttgaataag
     5041 cagttggata accataccat gcagtatgac agctataagg ttgataacta tgcagggatc
     5101 aaaacgagtc gagaagttcc tatgtatcaa gccttggcag aatcgcttaa tctacctgct
     5161 gttgccactg ttaatgattt gggtgtcgac aaggcttttg aggcaggcga aaaattcgga
     5221 ctcaacatgg aaaaggttga ccgtgttctt ggtgtcgcct tgggaagcgg tgttgaaacc
     5281 aaccctcttc aaatggctca agcatacgcc gcctttgcaa atgaaggttt aatgcctgaa
     5341 gctcatttta ttagtagaat tgaaaatgct agtggacaag ttattgcgag tcataaaaat
     5401 tcacaaaaac gggtgattga taagtctgta gctgacaaga tgaccagtat gatgttgggg
     5461 actttcacca acggtaccgg tattagttca tcgcctgcag actatattat ggcagggaaa
     5521 actggaacaa ctgaagcagt ttttaatccg gagtacacaa gtgaccagtg ggtaattggt
     5581 tatactccgg atgtagtgat tagccactgg cttggctttc cgaccactga tgaaaaccac
     5641 tatctagctg gctctacttc aaacggtgca gctcatgtct ttagaaacat tgccaatacc
     5701 attttacctt atacgtcagg aagtaccttt acggttgaaa atgcttataa gcaaaatgga
     5761 attgcaccag ccaatacaaa aagacaagta caaaccaatg ataatagcca gacagatgat
     5821 aatttgtctg atattcgagg gcgtgcgcaa agtctagtag atgaggctag ccgggctatc
     5881 tcagatgcga agattaagga aaaggctcaa acaatatggg attcgatagt caatctattt
     5941 cgctaagatg cttgtcaaag cctagctttc ttgttataat ggataagatg gaggcgttat
     6001 ggcactaaaa aaagcaagcc tagcttgtgc ggtttgtggt tcgagaaact attcaatcaa
     6061 gatcagcgga aaccccaagc ctacacgact agaagtaaat aaattttgta agcattgtgg
     6121 caagtacact acacatagag aaacgagata ggagagagcg atgcgtttta ttggagatat
     6181 ttttagactt cttaaagaca caacgtggcc aactcgcaag gaaagctgga gagattttcg
     6241 ttctatcatg gaatacacag ctttctttgt agtaattatt tacatttttg accagttgat
     6301 tgtttcaggt ttgattcgat ttattaacat tttttagaag attggtggag ttaattacac
     6361 tagaaatctt ctatttatga aaggaaatat catggatagt tttgataaag gatggtttgt
     6421 tttacaaact tattctggtt atgaaaataa ggtgaaagaa aatctattac aacgtgcaca
     6481 aacctacaat atgttggata atattctacg cgttgaaatt ccaacacaaa cagtgcaagt
     6541 tgaaaaaaat ggaaagagaa aagaagtaga agaaaatcgc tttccaggtt atgttcttgt
     6601 agaaatggtc atgacagatg aagcttggtt tgttgttcga aacacaccaa atgttacagg
     6661 atttgtcgga tcacacggga acagatcaaa accaactcca ttattggaac aagaaattcg
     6721 tgacattttg gtatctatgg gacaaactgt tcaagaattt gatttcgatg ttgagattgg
     6781 tcaaactgta cgtattattg atggtgcttt tgcagactac actggtaaga ttacagaaat
     6841 tgataataac aaagtgaaaa tgattatctc tatgtttggt aatgacacag ttgcagaagt
     6901 aaacctaaac caaatcgcag aattataacc ctgagagagg ctggagcctc tcttttttgt
     6961 gcagtttagg agctaaaggg aacagaatgg agaaaatgga acaaatgtgt tttctaatct
     7021 gttagactgt atctagaaag gggaaaatta tgattaaaga attgtatgaa gaagtccaag
     7081 ggactgttta taagtgtaga aatgaatatt accttcattt atgggaattg tcggattggg
     7141 accaagaagg catgctctgc ttacatgaat tgattagtag agaagaagga ctggtagacg
     7201 atattccacg tttaaggaaa tatttcaaaa ccaagtttcg aaatcgaatt ttagactata
     7261 tccgtaa
//
LOCUS       DAVHIZ010000071         7246 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.073, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000071 DAVHIZ010000000
VERSION     DAVHIZ010000071.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 7246)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7246)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7246
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.073"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            31..342
                     /locus_tag="VVO18_001829"
     CDS             31..342
                     /locus_tag="VVO18_001829"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001859040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586925.1"
                     /translation="MLSGLIFFLAQGLLLFLLVVRLKHQFAEIYPQINKKIRFYYLGV
                     LTIDFLFFVLLAFISSQRFSSLMPIITACHSTFYYMTADYLGENYPDFYDKHISLWEC
                     L"
     gene            416..777
                     /locus_tag="VVO18_001830"
                     /pseudo
     CDS             416..777
                     /locus_tag="VVO18_001830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009014307.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
     gene            complement(816..1259)
                     /locus_tag="VVO18_001831"
     CDS             complement(816..1259)
                     /locus_tag="VVO18_001831"
                     /EC_number="3.1.1.96"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866552.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-tyrosyl-tRNA(Tyr) deacylase"
                     /protein_id="HEU5586926.1"
                     /translation="MKIIIQRVKKAQVSIEGQIQGKINQGLLLLVGVGPEDQEEDLDY
                     AVRKLVNMRIFSDVEGKMNLSVKDIEGEILSISQFTLFADTKKGNRPAFTGAAKPDMA
                     SDFYDAFNQKLAQEVPVQTGIFGADMQVELVNNGPVTIILDTKKR"
     gene            complement(1289..3511)
                     /locus_tag="VVO18_001832"
     CDS             complement(1289..3511)
                     /locus_tag="VVO18_001832"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019316080.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="HEU5586927.1"
                     /translation="MPKEVNLTGEEVVALTKEYLTEEDVYFVHKALVYAVECHSGQYR
                     KSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRMIV
                     DGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQ
                     ERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALV
                     DEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQS
                     DVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEV
                     AEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMIELQDQADDAKEFVDSVKENYLAE
                     EIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVE
                     IIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVA
                     NKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAE
                     AEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGR
                     GVAIHRVDCMNLRAQENYEQRLLDVEWEDQYSSSNKEYMAHIDIYGLNRTGLLNDVLQ
                     VLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
                     "
     gene            4505..5134
                     /locus_tag="VVO18_001833"
     CDS             4505..5134
                     /locus_tag="VVO18_001833"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690864.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="HEU5586928.1"
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIEKIN
                     KPICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMA
                     DVVTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETI
                     GRTDLPTGSMEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     gene            complement(5257..7149)
                     /gene="pepO"
                     /locus_tag="VVO18_001834"
     CDS             complement(5257..7149)
                     /gene="pepO"
                     /locus_tag="VVO18_001834"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000199272.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="endopeptidase PepO"
                     /protein_id="HEU5586929.1"
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLML
                     ATTDKWLAGEEVPEDAILENFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADF
                     TAKLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELL
                     TLWKESSANLLKAYDFSDEEIEDLLEKRLELDRRVATVVLSNEESSEYAKLYHPYSYE
                     DFKKFAPALPLDDFFKAVIGQLPDKVIVDEERFWQAAEQFYSEEAWSLLKATLILSVV
                     NLSTSYLTEDIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSP
                     EAKADVEKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKD
                     KVVNETASLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFP
                     AAILQAPFYDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAA
                     FKEKTQKVIDQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFY
                     NFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDGMWRSPE
                     ERVIIW"
BASE COUNT         1950 a         1706 c         1393 g         2197 t
ORIGIN      
        1 attagactcg agacatcttt tgagtggctc ttgctctctg gtttaatttt cttccttgct
       61 caaggactcc tgctatttct cttggtcgtc cgactcaaac atcaattcgc tgagatttat
      121 cctcaaatca ataaaaagat tcgcttctac tatttagggg ttctcaccat tgattttcta
      181 ttttttgttc tcttagcctt cattagttct cagcgttttt catctcttat gccaattatc
      241 actgcttgcc attctacttt ttattatatg acagctgact acctaggaga aaactatcca
      301 gacttttacg acaaacacat ctctttatgg gagtgtctct aaggaaaagg aggttttagc
      361 atgaaaaaaa atcatcttca tcaaaaccat tcaactcctt gtcattgatg gaatcatgct
      421 ggcatttttg acatttaaaa aggggggctt acttgggact ggattttgat ttatagcggt
      481 tggctcattt tctttcatcc tgtgctattg acctatcttt caaaccaact ttgtgaccac
      541 tttagtcaac tctattccca gattagaccg agattctggc gttttgcttt acaaattctc
      601 ctatgggata gcctgatgat tctctccttg gtgtctttaa gtgatattcc acttttcctt
      661 cagggaactc tcctcatcct aggacatctc atcccttcct atcgcatctg ccaaagcctg
      721 aaaagagact tcccccaagc atatcaagaa ccgatttctt tttggagtat tttatgatcg
      781 atgagaaaga ccaagccgac tgggcttggt ctttcttatc tctttttagt atctaggata
      841 atggtaacag gtccgttatt aaccagctca acctgcatat ctgctccaaa gatacctgtc
      901 tgaacgggca cttcttgcgc taatttttga ttgaaagcat catagaagtc tgatgccata
      961 tcaggtttag ctgcccctgt aaaggctgga cgattgcctt tcttagtatc cgcaaagagg
     1021 gtaaactgag aaatagagag gatttctcct tcaatatctt tgacagacag gttcatcttg
     1081 ccttctacgt ctgaaaaaat ccgcatattg accagttttc tcacagcata gtccaaatct
     1141 tcctcttggt cctctggtcc aacaccaacc agcaataaaa gtccctgatt gatttttccc
     1201 tgaatctggc cttctatact cacttgggct tttttaaccc gttggataat gattttcata
     1261 atagcctttc tagtaagagc taggacaact agccgttggt ccgtttgaca gagtaaactt
     1321 ctggcacact cttaatttta tcgacaaccg tggtcagtgt agagaggttg gcaataccga
     1381 aggacacatg gatattagca aacttcatat ccttggttgg ttgggcattg accgttgaaa
     1441 tattcttggt tgtatttgaa agaacttgca gtacatcgtt caacagtcct gtacggttga
     1501 gaccgtagat atcgatatgg gccatatact ccttatttga gctagagtac tggtcttccc
     1561 attccacatc aaggagacgt tgctcgtagt tttcttgggc acgcaggttc atacagtcca
     1621 cacggtgaat agccacacca cgacccttgg taatgtagcc aacaatatcg tcaccaggca
     1681 cggggttaca acacttagca atccgcacta ggagaccaga agcaccttca ataaccactc
     1741 ccccctcatg cttgaccttg agagtttctt tattttcaac cttgacctcg ccacctttga
     1801 caagctcctc tgcctcagcc ttggccttgg cacgctcttc ctcacggcgt tctttttcag
     1861 tcagacggtt aaagacggta atcgcaccga tttccccaaa accaatggcc gcaaagaggg
     1921 agtcttctgt cttgtaactg gtcttttgca gaacttgatc catgtggcgc ttgtccataa
     1981 atttatttgc cacatagcca ttttcttgga actgagccat cagcatctca cgacccttgt
     2041 tgacagacaa ttccttatct tggtttttaa agaactggcg aatcttattg cgcgccttgc
     2101 tagtcttgac catattgagc cagtcacggc taggtccaaa ggagttcggg ttggcgataa
     2161 tttcaacctg atcccctgtc tttaacttgg ttgtcagtgg aaccatgcgg ccattgacct
     2221 tggcaccagt tgctttttca ccgaccttgg tatggatttc gtaggcaaaa tcaatcggtc
     2281 ctgaatcttt gggaagagaa cggacagctc catctggggt aaaaacgtaa atctcctcag
     2341 ccagatagtt ttccttaaca gagtccacaa attccttagc atcatcagcc tggtcttgga
     2401 gctctatcat ctccttgatc cagttcattc caatagctga ttccttgctg ttaacttgcc
     2461 cctttatacc tttcttataa gcccagtgag ccgcaacccc gtactcagcc acctcgtgca
     2521 tttccttggt tcgaatctgg aattcaatcg gcccttttgg tccataaaca gtcgtatgga
     2581 tagactgata accattggcc ttgcggttgg cgatatagtc tttgaagcga cctggcatcg
     2641 gtttccaaaa ttcatgcacg taaccaagca tggcataaac atcactttgg gtatctaaaa
     2701 tacaacgaat agcaatcaga tcatagattt cctcaaaccg ttttctcttg tcctgcattt
     2761 tgcggaaaat tgagtaaata tgcttgggac gaccataaat cttccctttc aagtgacgtt
     2821 ctgtcgtata ctcctctaat tttgtgacta cctcatccac caaggcctca cgctccctgc
     2881 gcttttcctt catcatatgg gtaatcttgt aaaactccgt tggattgaga taacggaaag
     2941 acaagtcttc taattcccat ttgacactgg aaatccccaa acgatgggca agcggggcat
     3001 agatttccat ggtttctttg gaaatacgct cctgcttgtc ttttcgaaga tgtttcaggg
     3061 tccgcatatt gtgcaagcgg tcagacagtt tgaccaaaat aacgcggatg tcctcagaca
     3121 tggccatgag catcttgcga tgattttccg ctaattgctc ctcgatcgat ttgtactcga
     3181 ccttgccaag cttggtaact ccgtcaacaa tcatccgcac atcaggacca aactctcttt
     3241 ccaaatcgtc caaggtcgca tctgtatctt ccaccacatc atgcaagaat ccacaagcta
     3301 ctgttacagc atccagcttt agcttagcta aaatacctgc cacttggata gggtgaatga
     3361 tataaggctc gcctgatttg cgatattgac cactgtggca ttcaacagca tagaccaagg
     3421 ccttatggac aaaataaaca tcctcttccg ttaaatattc tttggttaaa gcgacaactt
     3481 cttcgcctgt taaattcact tctttcggca tctctactct ccaattcttc ctaccatttt
     3541 atcacttttt taagaatatg aaaactagat tggaacagaa taagaaaaaa ataattcaaa
     3601 attgcttgat aattctgaat tattggccca taatatacta cgaagttaga ttttaaactt
     3661 aggtgataga aggagagata gaagaacgga aaccatattg taacccaaag actttctgat
     3721 ttccccaatt ccattgaaga tacgaaagat aaacggtgga actcgtatca catacactgg
     3781 taccttgact ggattttgga attaatactc aatgaaaatc aaagagcaaa ctaggaaact
     3841 agccgcaggt tgctcaaagc actgctttga ggttgtagat aagactgaca aagtcagtca
     3901 catatatacg gcaaggcgac gttgacgcgg tttgaagaga tttttgaaga gtataaaaat
     3961 cctcaagata ctttcttcta tcctttagtt tataaggaga atacctatga aaaaaactgc
     4021 tatttctatc tttgctctcc taatgttagg agtttgctgc ctgttcctat tcagccagca
     4081 aagctataaa aaactcgttc aatactatgc taacgaccag aacctgccca gtaggataac
     4141 ttatagtgaa tatagcgaca aatgagaagc caactacggt agcactctaa acatcacgtc
     4201 tatcaaacaa gctaatgacg gagtttatgc aacctatgaa gggcaattga cacctttcca
     4261 atattgataa attgataacc agcctgtctt catctagtca tgctggtttt taagttcatt
     4321 ttaaatcctt acctattctc cctaactgtg ctatacttaa tttatactca atgaaaatca
     4381 aagagcaaac tagaaagcta gccgcaggct gttcaaagca ctgctttgag gttgcagata
     4441 aagttgacgc ggtttgaaga gattttcgaa gagtattagt acattctttg agattggagc
     4501 tagtatgaaa atccataaaa ccgtgaatcc tgttgcctat gaaaatacct attatctaga
     4561 aggcgaaaag cacctcatcg tcgtcgatcc tggtagtcat tgggaagcca ttcgtcagac
     4621 aatcgagaag atcaacaaac cgatctgtgc tattctcttg acccacgccc attatgacca
     4681 tatcatgagt ctggacttgg ttcgcgagac gtttggcaat cctcctgtct atatcgcaga
     4741 gagcgaagcc agctggctct acactcctgt cgataatctc tccggtctcc ctcgccacga
     4801 tgatatggca gatgtggtca caaaacctgc agaacacacc tttgtctttc acgaagaata
     4861 ccaactagag gaatttcgtt ttaaggttct accgacccca gggcactcta tcggtggtgt
     4921 ttccctagtc tttcctgatg ctcacctagt cttgacggga gatgctctat tccgcgaaac
     4981 tatcggacgg accgaccttc cgactggtag catggagcaa ctccttcata gtatccagac
     5041 ccaactcttc accctaccaa actacgatgt ctatccagga catggtccag ctactactat
     5101 cgctcacgaa aaggccttca atcccttttt ctagcaagat gatgacaatc gaaatttaag
     5161 taaactatcc agcaaatctt tctattacaa aaggcatcct atcaaggttt tcacacgtga
     5221 ttggatgcct tttttctgat gactagattt tttgtattac caaataatca cgcgctcctc
     5281 tggtgaacgc cacattccgt ctccttcttt gacatcatag gttgtaaaga aatcgtcgaa
     5341 gtttggtact tgcacattga cacggagttt ggctggtgcg tgcacatcga cgctagccaa
     5401 aagtttcata aattctggtc gacctttcat gcgccagatg cgaccgaagt tgtagaagaa
     5461 ctcttctgct gagaagtctg cttctctctt agctgcttca agcgctgctg cgattcctcc
     5521 caagtcagcc acgttttctg atacagtcaa tttaccgtta atggttgctc cataagaatc
     5581 ctgtccatca aattggtcaa tgactttttg tgttttctcc ttgaaggcag catagtcgct
     5641 ctctgtccac caatccttga ggctaccatt ttcgtcaaag gaagccccgt tagtatcaaa
     5701 ggcgtgggaa atttcatggg caatcactgc cccaatacca ccgtagttag cagaagatga
     5761 ctgatgcaag tcatagaaag gcgcctgtaa aatggccgct ggaaagacaa tcaggttctt
     5821 ctgaggattg tagtaggcat tgaccatatg agcaggcatg ccccattcct tataatctac
     5881 aggctggttc cacttactcc aactgtgctt gatttccaca cgcgcaaagg ctagagcatt
     5941 ctcaaaaaga ctggcagttt cattcactac cttatccttg taacgtgcag gcaattcttc
     6001 tggatagcca atataaggtt tgatcacatt gagcttcacg atagcctgtt tacaggtttc
     6061 tggagtgagc cagtcattct taagcagacg ctccttataa acatcaatca tggttgccac
     6121 ttttttctcc acatccgcct tggcttctgg agagaacttc tcacgggcgt accaaagacc
     6181 cagggcttgc ttgaaaggtt cttgtgctag atgataagct gctttgacct tatcttttgc
     6241 ctctggaact ccagaaaggg cacggctgta ggcaccagac aaaacacgga tatcctctgt
     6301 taaatagctg gttgaaagat tgacaacact caaaatcaag gttgctttaa ggagagacca
     6361 ggcttcctca ctgtagaatt gctctgctgc ttgccagaaa cgttcctcgt ctacaataac
     6421 cttgtctggt aattgcccaa taactgcttt gaagaagtca tccaaaggta gggcaggcgc
     6481 gaatttcttg aaatcttcgt aagaatatgg atgatagagt ttagcatatt ctgaactttc
     6541 ttcattagag agcaccactg tcgcaactcg gcggtccaat tcaagtcttt tttctagcaa
     6601 gtcttcaatt tcttcatcag agaaatcata agccttgagg agatttgcgc tgctttcttt
     6661 ccaaagagtc aagagctctt cgcgctgagg atgttcttct gcatagtagg tcgtatctgg
     6721 caagattgtg cttggagcgc tagcccatag aacattgatt ctagcatcca taaagtctgg
     6781 cgatacacca aaaggaagga agtttggttt tcctgcaagc tcaaactctg ctagtttagc
     6841 tgtaaaatcc gcaaaagtct ccaattcttg gaattcttta aggagtggta agacaggtgt
     6901 gataccgtca gcttctctct tgtcaaaatc acgaactagg cggtggtatt tgacaaagtt
     6961 ttccaagata gcatcctcag gcacttcttc acctgctaac cacttgtctg ttgtcgccag
     7021 catcaggtct tcaatttcct ggtctaaatc aacaaaacct ccagtttgag acttatctgc
     7081 tgggatttca gctgtctgtt gccattctcc attgatagca tcataaaaat catcttgata
     7141 acgtgtcatc ttgttctcgc tttcatttgt atttgcattt atcttaacaa aaatcactag
     7201 ggaatgcaat taataaccat ttaactatta ttttttagct attata
//
LOCUS       DAVHIZ010000072         6876 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.074, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000072 DAVHIZ010000000
VERSION     DAVHIZ010000072.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6876)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6876)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6876
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.074"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            87..3437
                     /locus_tag="VVO18_001835"
     CDS             87..3437
                     /locus_tag="VVO18_001835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000526318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase family protein"
                     /protein_id="HEU5586930.1"
                     /translation="MGNFSFLLKNDEYESFSKPCIEAENMIATSTVATAFMARRALEQ
                     AVHWIYSHDSYLEAPYRATLSSLVWDDDFRDIVDSELHKQIVLLIRWGNHAAHGGEIK
                     EREAILALHHLYQFVNFIDYCYSNEFVERYFDEKCLPLSANIKYRETPQSMIKLQDSL
                     PELPDFHEQMAAQSVEVQETYTEKRETAAQRQDVPFHIEQLSEAETRKLFIDIDLRLA
                     GWIFEENCRVEIAVDGLKHGSGIGYCDYVLYGKNGKILAIVEAKKASVNPEVGEVQVK
                     EYAEALEKHIGYQPICFITNGLKHYILDGPNRRQIAGFYSQEELQLVMDRRHLQKPLE
                     DISSKIRDDISGRHYQKHAIASVCEAFSNHRRQALLVMATGAGKTRTAVSLVDILSRH
                     NWVKNVLFLADRTSLVKQAYDSFRKLLPDLSVCNFLEDKEGAQSSRMVFSTYPTMIGA
                     ISGQEEVNQRPFTVGHFDLIIIDESHRSIYQKYKSIFDYFDARIVGLTATPRQDLDKN
                     TYGFFNLENGVPTYAYDLEEAVKDGYLVAYHSIETKLKLPTDGLHYDDLSEEEKEHFD
                     SKFEDNSCEKDIDGSVFNSFIFNKSTVEIVLNELMTRGIQTASGDEIGKTIIFAKNHD
                     HAEYIRGIFNNRYPEKGSDYAQVIDYSIKHYQTLIDDFKIKEKYPQIAISVDMLDTGI
                     DVPEVVNLVFFKKVRSKTKFWQMIGRGTRLCKDLFGPEQDKENFLVFDYGDNFDYFRA
                     DPRDGEGRHIVSLTQRLFNIKVDLIRELQGLQYQEDQFARAYRQQLVSELQGRIESLN
                     ELDFRVRMVLDTVYSYRKLESWQNLTAVTSETIQKNLSPLLFDEDKEDEMARRFDLWL
                     LHIQLEQLTAKSSTVHISQVMKTARALSAIGNIPQVFEQAEIIRKVQEPEFWKEVNLS
                     DLEKIRLAIRDLLQFLDKTDRKPYYVNFEDRILSTVHETTAFLQVNDLRSYNEKVEHY
                     LKTHLDEESISKLYHNKKLTSDDMLALEKLLWEKLGSKADYQSHYENKAIPRLVREII
                     GLDRESANRIFSKFLSDENLNARQISFVKLIVDYIVENGFLETKVLTQEPFKSYGSVQ
                     LLFQHQLPVLRNIVQIIELINNRAGEAA"
     gene            3708..3863
                     /locus_tag="VVO18_001836"
     CDS             3708..3863
                     /locus_tag="VVO18_001836"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586931.1"
                     /translation="MKIKEQTRKLAAGCSKHCFEVVDETDEVSNHTYGKATLTRIEEI
                     FEEYKSS"
     gene            complement(3980..4450)
                     /locus_tag="VVO18_001837"
     CDS             complement(3980..4450)
                     /locus_tag="VVO18_001837"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="arginine repressor"
                     /protein_id="HEU5586932.1"
                     /translation="MNKSEHRHQLIRALITKNKIHTQAELQALLAKNDIQVTQATLSR
                     DIKNMNLSKVREEDSAYYVLNNGSISKWEKRLELYMEDALVWMRPVQHQVLLKTLPGL
                     AQSFGSIIDTLSFPDAIATLCGNDVCLIICEDADTAQKCFEELKKFAPPFFFEE"
     gene            complement(4467..6740)
                     /locus_tag="VVO18_001838"
     CDS             complement(4467..6740)
                     /locus_tag="VVO18_001838"
                     /EC_number="3.4.14.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399325.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Xaa-Pro dipeptidyl-peptidase"
                     /protein_id="HEU5586933.1"
                     /translation="MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRF
                     FFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDV
                     FRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLAT
                     FSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKA
                     SDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDY
                     FLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVK
                     ADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGG
                     YPGEDFDSLAELTYSRNLLAGDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYL
                     LNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSID
                     FRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQ
                     AIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSS
                     TNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKG
                     YLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNT
                     DYHLTVDLAQSMLTLPC"
BASE COUNT         2115 a         1156 c         1484 g         2121 t
ORIGIN      
        1 gcttgtgaga tagctataaa agtgtggaga aatagcttga aatttagtat aatatagcta
       61 aactatttgt ttaaagtgag aaaaaaatgg gaaattttag ctttctttta aaaaatgacg
      121 aatatgaatc tttttcaaaa ccttgcattg aagctgaaaa tatgattgct acatcaactg
      181 tggctactgc ctttatggcg cgtcgtgctt tggagcaggc tgtccattgg atatatagtc
      241 acgattcata tttagaagct ccctatcgtg ctactctatc ttctttagta tgggatgatg
      301 attttaggga tatcgtagat tctgaactcc acaagcagat agttctgttg attcggtggg
      361 gaaaccatgc tgctcatggt ggtgaaatta aggaacgaga agcgatttta gctttacatc
      421 atttgtatca gtttgttaat tttatcgatt attgttacag caatgaattt gtggagcgtt
      481 attttgatga gaagtgctta ccactttcag caaacatcaa ataccgagaa actccacaat
      541 ctatgataaa gttacaagac agtttaccag aactgcctga ttttcatgaa cagatggctg
      601 ctcagtccgt agaagttcaa gagacttata ctgaaaaacg tgagactgca gcgcaacggc
      661 aagatgtgcc tttccatatt gaacaattat ctgaggcaga gacaagaaag ctctttattg
      721 atatcgatct ccgtttagca ggatggatat ttgaagaaaa ctgtcgtgtt gagatagccg
      781 ttgatggtct caagcacggt tcaggaattg gttactgtga ctatgtactt tatggtaaaa
      841 atgggaaaat tttagcgatt gtggaggcta aaaaagcctc tgtcaatcca gaagtagggg
      901 aagtacaggt caaagaatat gctgaagctc ttgagaaaca tatcggctat cagccaattt
      961 gctttattac aaatgggttg aagcactata tacttgatgg tccgaaccgc cgccagattg
     1021 caggctttta ctctcaagaa gaattgcaat tagtgatgga tagacgtcat cttcaaaaac
     1081 cgcttgagga tatttctagt aaaattaggg acgatatttc cgggcgtcac taccaaaaac
     1141 atgccattgc aagcgtttgt gaagctttct ctaatcatcg tagacaggca cttttggtta
     1201 tggcaactgg ggcggggaaa actcgtacag cagtttctct agttgatatc ttatcacgtc
     1261 ataactgggt aaaaaacgtt ctcttcttag ccgatagaac ttccttggtt aagcaagcct
     1321 atgattcgtt tagaaaatta ctcccagatc tttccgtttg taacttctta gaagataaag
     1381 aaggagctca atcaagtcgt atggtctttt caacttatcc gaccatgatt ggagcgatta
     1441 gtggtcaaga agaagtaaat caacgccctt ttactgttgg gcattttgac cttatcataa
     1501 ttgacgaatc tcaccgttct atttatcaga aatacaagtc catttttgat tattttgatg
     1561 caagaattgt aggcttaaca gctactccgc gtcaagattt agataaaaac acctatggat
     1621 tctttaattt ggagaatggg gttccaacat atgcatatga tttggaagag gctgttaaag
     1681 acggatattt agtagcctat cattctatcg aaaccaaact gaaactacct acggatggtc
     1741 tacattatga tgatttgtcc gaagaagaaa aggaacattt tgatagcaaa tttgaagaca
     1801 atagctgtga aaaagatatt gatgggagtg tatttaattc ctttattttc aataaaagta
     1861 cagtagaaat tgttttaaat gaactcatga caagaggaat tcagacagcc tcgggtgatg
     1921 aaattggtaa aactattatt tttgctaaaa atcatgatca tgcggaatat atcagaggta
     1981 tttttaacaa ccgctatcct gaaaaaggga gcgactatgc tcaggtgatt gattatagta
     2041 ttaagcatta tcagaccttg attgatgatt ttaaaattaa ggagaagtat cctcaaattg
     2101 cgatttctgt cgatatgtta gatacaggta ttgatgtacc agaggttgtt aatttagtct
     2161 tcttcaagaa agtacgctct aaaactaagt tttggcagat gattggtcga ggaacccgtc
     2221 tatgtaaaga tttatttgga cctgagcagg ataaggaaaa cttcttggta tttgattatg
     2281 gggacaattt tgattatttt cgtgcagatc caagagatgg agagggtcgt cacattgttt
     2341 cgctgactca gcgtttattt aatatcaaag tggacttgat tcgagaactt cagggactcc
     2401 aataccaaga agatcagttt gcgagagcat accgtcagca gcttgtctcg gaacttcaag
     2461 gtcgtataga gagcttaaat gagttggact tcagggttcg tatggtttta gatacagttt
     2521 atagctatag gaaattggaa agttggcaga atctaactgc tgttacaagt gaaaccattc
     2581 aaaaaaatct ctctccgctt ttatttgatg aagataaaga agatgagatg gcgaggagat
     2641 ttgatttgtg gttgcttcat attcagttgg agcaactgac agctaaatct tccactgttc
     2701 atatttccca agtgatgaag acggctagag ctctttctgc tattggcaat atcccacagg
     2761 tttttgagca ggctgaaatt atcaggaaag tacaggagcc tgaattttgg aaagaagtta
     2821 acttgtctga tttggaaaaa attcgtcttg ctattcgaga tttattacag tttttggata
     2881 aaacagaccg taaaccctac tatgttaact ttgaagatcg tatactctcc actgttcacg
     2941 agaccacagc atttttgcag gtcaacgatc ttcggtctta caatgaaaaa gttgagcatt
     3001 atttgaaaac tcatctggat gaggagtcca tttctaagtt ataccataat aaaaagttga
     3061 catctgatga tatgcttgca cttgaaaaat tgctttggga aaaattaggt agtaaagcag
     3121 actaccaaag tcattatgaa aataaggcaa ttccgagatt ggttcgtgag attattggct
     3181 tagatagaga gtctgccaat cgtatttttt ctaaattttt gtcggatgag aatcttaatg
     3241 ccaggcagat ttcatttgta aaattgattg tagactacat tgtagaaaat ggttttttag
     3301 agacgaaagt gttaacgcaa gagccgttta aatcttatgg ttctgttcaa ctactcttcc
     3361 aacaccaact accagtactt cgtaatattg ttcaaatcat tgaacttatc aataatcgag
     3421 ctggagaagc ggcttaaatt ctaaagtgat tgccatgctg agactcattt aaaattaaaa
     3481 agagtagaaa tttatgctat atatgagaag ttttattagg aagaatgtca tcgttttcct
     3541 agaatacagt atcagttgtt aagtggttga taaatttcaa agtagatact tgtaccacga
     3601 tgtttgttga tcgagttatt aacaaaagag ctactttgat tttaaagaaa tagaaaacaa
     3661 aaagctgagc aagaattcaa ttgcaggaga aaatgaaata atactcaatg aaaatcaaag
     3721 agcaaactag gaaactagct gcaggctgct caaaacactg ttttgaggtt gtagatgaaa
     3781 ctgacgaagt cagtaaccat acctacggca aggcgacgtt gacgcggatt gaagagattt
     3841 tcgaagagta taaatcttcc taggataaag caaaacgcat agtatcaagg gttttcaaca
     3901 cttgatacta tgcgttttct gatgttaaag actttctacc aggtttttta aaagcataat
     3961 tgttagttgt agtcatttat tattcttcaa agaaaaatgg tggggcgaat tttttcagtt
     4021 cttcaaagca cttttgagca gtatctgcat cttcacagat gataagacag acatcattac
     4081 cacaaagggt agcgatagcg tcagggaagc tcaaagtatc aatgatagaa ccaaaggatt
     4141 gagccagtcc aggaagggtt tttagtagga cttggtgttg aactgggcgc atccagacaa
     4201 gggcgtcttc catgtagagt tcgagacgtt tttcccattt tgagatggaa ccattgttaa
     4261 gaacataata agcgctatct tcttcgcgga cttttgatag gttcatattt ttgatgtcgc
     4321 gtgagagggt tgcctgggtt acttgaatgt cgttcttagc aagaagggct tgcaactcag
     4381 cctgtgtatg aatcttgttt tttgtgataa gagcgcgtat aagttggtgg cggtgttctg
     4441 atttattcat aataatgtaa ctccttttag caaggtaagg taagcatgga ctgagcgagg
     4501 tcgacagtca agtggtagtc tgtattgtca cggatggtga tttcaaagtc agtagtatag
     4561 aggactaaac ggagagtgtc tccttctttt agcttgtaaa tagttggctg cagttcaaat
     4621 tgaacgtcca tccattcatc tgcagtaata tcctctacta acagtaaatc atttctattt
     4681 tgtaaattaa ggtaaccttt tgtcacgact cgttgtgcct ctggtctaaa tggcaattca
     4741 cagagatttt ccaacatgtg atagcgaccg ttgtcaatgg ttctagcact taaaatagct
     4801 ggataaggtt gtaggtattt cttttgccca aattctagca gttgggcaga taagagcccc
     4861 ttgtttgtac tggatttgat acgaagattg agctgagcgc gaccgtttag gtggagatct
     4921 ttagtcacag gaaggttaat agtaatctga ttagctttcc cttgatagag ctctgtattg
     4981 aaggtttggt atgtcttacc atagcgctca aaatccttat ctgggtactg gttttgaata
     5041 gcttgctctt cttgaccaag tgagaaggtt tcacagtttt cttgcccacc gaagttatca
     5101 agtgataacc aagtctgtgg agctgtattg tcctgccaga taacagtagg aagttgaaag
     5161 tctgtttcct gtcctagtaa tttcttggtc aataaggcat ttatggactc acggaagtca
     5221 attgattgcc aattgttcat gtaaacatgg gcaccattat ggaaaaagag atgcttgtgt
     5281 atatgagtag gaagagcatg gaacatctgg taaacatgaa gtggtttgac attccaatcc
     5341 tgagaaccat gagtaaagac aacctctgcc tttactttat gggcattgag cagataattg
     5401 cggtcatgcc aaaactgatt gtagtcccca gtttttcggt ctagctgagc tttcactttt
     5461 tctaagtcag cttggtgagc ttcattgcca cggatatagt cgccagctaa gagattacga
     5521 gaataggtta actcagcaag ggagtcaaag tcctcacctg gataaccacc tgggctagtc
     5581 accagaccgt tttcacggta gtagttgtac catgatgaaa ttcctgcctc ggcaatgata
     5641 acttctaaac catcgactcc tgtagtcgca agaccattgg acatggtacc tagataggaa
     5701 agtcctgttg tagcaacttt tccgtttgac caatcagcct tgacttgacg ctggcgcgtg
     5761 tgatcagtaa aggcacggca acgaccgtta agccaatcga tgacgttttt ataagcctcg
     5821 atttgctggt agtctccatt agtcatgaaa cctgtcgagt ctttggtacc aacacctgag
     5881 acatagagat tggcaaagcc tctcggaagg aagtagtcgt ttagtgtata gctagagttg
     5941 atgtgagtta gcttttcctc agcctctgct ataagctcag ctttaccttg gggttggacg
     6001 agatttagtt gaggtttctc tagctcaatc ttgtgaggaa gcttaacctc aagctcgccc
     6061 tccatcttgt agagagcctt gtcactagcc ttgtcattgg ttccctgatg ataagggctg
     6121 gctgtcatga tggcagggat ttttccatca aaacgagggc gaataatgct aacctttact
     6181 aggtctgata gccctttttg gtcagtatcg acacgagact caacgtaaac gacttcacga
     6241 atgacatcct ggttagaaaa agtagccaaa ctcttgccgt taaagtagtg gtagtcatta
     6301 tcctccggaa taagaccatc actaacaagt tggtcgataa gagtatttcc ttttttggtg
     6361 cgagtattga gtaactgata gagattttca atcaagtcac catatataat gggaaatcca
     6421 gtttctttac gaaaaacgtc actatcttcg aagtcaacca aataagaaaa gcctaaaagt
     6481 tgaaaagcaa cagtataaaa aatatctgct gtcagttcat cttctgattg aaaaaatgtc
     6541 agcaggtctg tttttttatc agctgctagg atagaaagtg ggtagttggt gtcttgataa
     6601 gtgaaaaaga aacgacgtaa aaaggtttca agtgagtctt tgtgattggc tgtattttgt
     6661 aaatcaaagc cacatttttt tagttcagat aagacatttt cttttggaaa attgatataa
     6721 ctatattgat taaaacgcat agaacctcca tatagaatga cagttaaggt tattatatca
     6781 aaaaaaaagc agaaagggaa ttgttaactt caaaaggaaa taatccaata aaaatgaata
     6841 aagtactaaa ttcaatatag agaacagagt aacaat
//
LOCUS       DAVHIZ010000073         6296 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.075, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000073 DAVHIZ010000000
VERSION     DAVHIZ010000073.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6296)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6296)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6296
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.075"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            1..292
                     /locus_tag="VVO18_001839"
                     /pseudo
     CDS             1..292
                     /locus_tag="VVO18_001839"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus and C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            459..659
                     /locus_tag="VVO18_001840"
     CDS             459..659
                     /locus_tag="VVO18_001840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000226586.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586934.1"
                     /translation="MVASASASSTSTQAQEQVDKSELRALSQELDQRLKALATVSDPK
                     IDATKAVLLDAQKAPEDSALTE"
     gene            684..1100
                     /locus_tag="VVO18_001841"
     CDS             684..1100
                     /locus_tag="VVO18_001841"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000642281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586935.1"
                     /translation="MKAALESLKDVKANASDSKPAQDKKDAKQGTEDSKDSDKMTETN
                     SVPAGVIVVSLLALLGVIAFWLIRRKKESEIQQLSTELIKVLGQLDAEKADKKVLAKA
                     QNLLQETLDFVKEENGSAETETKLVEELKAILDKLK"
     gene            1331..2038
                     /gene="ccdA2"
                     /locus_tag="VVO18_001842"
     CDS             1331..2038
                     /gene="ccdA2"
                     /locus_tag="VVO18_001842"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004237834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     membrane protein CcdA2"
                     /protein_id="HEU5586936.1"
                     /translation="METIVFLISVFLAGVLSFFSPCIFPLLPVYAGILLDDQESAKSF
                     SLFGRKVLWSGLIRTLCFIAGISLIFFILGFGAGYFGHILYANWFRYGMGAIIIILGL
                     HQMEIFHLKKLEVQKSFTFKKSDSNRYWSAFLLGITFSFGWTPCIGPVLSSVLALAAS
                     GGNGAWQGAIYTLIYTLGMALPFLVLALASGLVMPYFSKIKRHMMLLKKIGGFLIVLM
                     GILLLLGQVNVLAGIFE"
     gene            2049..2606
                     /gene="sdbB"
                     /locus_tag="VVO18_001843"
     CDS             2049..2606
                     /gene="sdbB"
                     /locus_tag="VVO18_001843"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thiol-disulfide oxidoreductase-associated
                     lipoprotein SdbB"
                     /protein_id="HEU5586937.1"
                     /translation="MKKVMFAGLSLLSLVVLMACGEEETKKTQAAQQPKQQTTVQQIA
                     VGKDAPDFTLQSMDGKEVKLSDFKGKKVYLKFWASWCGPCKKSMPELMELAAKPDRDF
                     EILTVIAPGIQGEKTVEQFPQWFQEQGYKDIPVLYDTKATTFQAYQIRSIPTEYLIDS
                     QGKIGKIQFGAISNADAEAAFKEMN"
     gene            2980..4371
                     /locus_tag="VVO18_001844"
     CDS             2980..4371
                     /locus_tag="VVO18_001844"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020339.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid permease"
                     /protein_id="HEU5586938.1"
                     /translation="MNIFRTKNVSLDKTEMHRHLKLWDLILLGIGAMVGTGVFTITGT
                     AAATLAGPALVISIVISALCVGLSALFFAEFASRVPATGGAYSYLYAILGEFPAWLAG
                     WLTMMEFMTAISGVASGWAAYFKGLLSQYGIALPQALNGTFNPQAGIFVDLLPILVLV
                     LVTSLVLLNAKAALRFNSILVILKFSALALFVLVGIWNIKFDNWSNFAPYGFGQIYGA
                     STGIMAGASLMFFGFLGFESISMAVDEVKTPQKNIPRGIVLSLSIVTILYALVTLVLT
                     GVVHYSHLNVDDAVAFALRSVGISWAANYVSLVAILTLITVCISMTYALSRMIYSLAR
                     DGLVPAAFKELTKTSKIPKNATILTGLASAVAAGMFPLASIAAFLNICTLAYLIMLAY
                     GLIRLRKEKGMPKAGEFKTPLVPLLPILSIIICLSFMLQYNMNTWIAFLVALLVGSII
                     YFTYGYKHSTIEE"
     gene            4514..5431
                     /gene="adcAII"
                     /locus_tag="VVO18_001845"
     CDS             4514..5431
                     /gene="adcAII"
                     /locus_tag="VVO18_001845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000744528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding lipoprotein AdcAII"
                     /protein_id="HEU5586939.1"
                     /translation="MKKQNLFLVLLSVFLLCLGACGQKESQTGKGMKIVTSFYPIYAM
                     VKEVSGDLNDVRMIQSSSGIHSFEPSANDIAAIYDADVFVYHSHTLESWAGSLDPNLK
                     KSKVKVLEASEGMTLERVPGLEDVEAGDGVDEKTLYDPHTWLDPEKAGEEAQIIADKL
                     SEVDSEHKETYQKNAQAFIKKAQELTKKFQPKFEKATQKTFVTQHTAFSYLAKRFGLN
                     QLGIAGISPEQEPSPRQLTEIQEFVKTYKVKTIFTESNASSKVAETLVKSTGVGLKTL
                     NPLESDPQNDKTYLENLEENMSILAEELK"
     gene            5439..>6296
                     /gene="phtB"
                     /locus_tag="VVO18_001846"
     CDS             5439..>6296
                     /gene="phtB"
                     /locus_tag="VVO18_001846"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtB"
                     /protein_id="HEU5586940.1"
                     /translation="MKINKKYLAGSVAVLALSVCSYELGRYQAGQDKKESNRVAYIDG
                     DQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISE
                     ELLMKDPNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIKRQKQER
                     SHNHNSRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNEL
                     SASELAAAEAYWNGKQGSRPSSSSSYNANPAQPRLSENHNLTVTPTYHQNQGENISSL
                     LRELYAKPLS"
BASE COUNT         1931 a         1121 c         1335 g         1909 t
ORIGIN      
        1 ccagaaaaag tagccttatt tcttaagaat tttaatagtt taaagcacct agcacctgtt
       61 tagattgacg aaacaggatt tgatacttat ttttatcgag aatatggtcg ctctttaaaa
      121 ggtcagttaa gaagaagata tcagaggatt tctttggttg caggtctaac aaatgaatgg
      181 tgagttaatc gctccaatga cttacgaaga gacgatgacg agcgactttt ttgaagcatg
      241 gtttcagaag tttctcttac caacattaac cacaccatcg gttattatag taaaatgaaa
      301 taagaacagg acaaatcgat caggacagta aaatcgaatt ctaacaatgt tttagaagtc
      361 tatatgtact attctagttt caatatacca taactgctcc tagtcaacct gcaagtcctg
      421 tcccagctcc aagctcagct ccgactcaag atcctagagt ggtagcaagc gcttcggcta
      481 gctcaacgag cacacaagct caagagcaag ttgacaagtc tgaacttcgt gccttgagtc
      541 aagagttaga ccaacgcttg aaagctttgg caacagtatc tgatccaaaa atcgatgcaa
      601 ccaaggctgt cctcctagat gctcaaaaag ctccggaaga tagtgccttg acagagtaag
      661 gtctgcgtac tgcagtagag tctgtgaagg ctgccttgga gtctctcaaa gatgtgaaag
      721 caaatgctag cgatagcaag cctgcacagg acaagaagga tgcaaaacaa ggaacggaag
      781 atagtaagga ttcagataag atgactgaaa caaactcagt tccagcagga gtgattgtgg
      841 tcagtctact tgccctccta ggcgtgattg ccttctggct gattcgccgt aagaaagagt
      901 cagaaatcca gcaattaagc acggaattga tcaaggttct aggacagcta gatgcagaaa
      961 aagcggataa aaaagtcctt gccaaagccc aaaaccttct ccaagaaacc cttgatttcg
     1021 tgaaagaaga aaatggctca gcagagacag aaactaaact agtagaggag cttaaagcaa
     1081 tccttgacaa actcaagtaa aacatgattt atgaaatgtc agacctaaaa gacattttcg
     1141 ttcacaaaag cagcgatgag taatccttgt cgttgctttt tggctatttt gggggataag
     1201 atccgccttg actagcaaaa gaaaagattg gtccaatagt gcccgatacg attttgcgta
     1261 gcagaaagct tacaaataaa attgaatata gtaaaatagg attagaatta ttaagaaagt
     1321 tggttcttta ttggaaacga tagtattttt aatctctgtt tttctagcag gtgttttatc
     1381 ctttttttct ccttgtattt ttcctcttct gccagtctat gctgggattt tattggatga
     1441 tcaagaaagt gcaaaaagct tttctttgtt tgggagaaag gttctctggt caggcttgat
     1501 tcgaacactt tgctttatcg ctggtatctc tctcattttc tttattctag gctttggtgc
     1561 tggttacttt ggtcatattc tctatgcaaa ttggtttcga tatggcatgg gagctattat
     1621 tatcattttg ggtcttcacc agatggaaat ttttcatttg aagaaattag aagttcaaaa
     1681 aagttttacc tttaaaaaat cagattctaa tcgttattgg tcagcttttt tacttggtat
     1741 tacctttagc tttggttgga caccttgtat tggtccagtt ttaagttctg ttttagcact
     1801 tgcggcttct ggaggcaatg gcgcttggca aggagcgatt tatactctca tttacactct
     1861 gggcatggcc cttcctttct tggtattggc actagcttca ggtctagtca tgccatattt
     1921 tagtaaaatc aagcgtcata tgatgctact aaagaaaatt ggtggtttcc tcattgtttt
     1981 aatgggaatt ttgttactat taggacaagt aaatgttcta gctggaattt ttgaataaag
     2041 gaggacaaat gaaaaaagta atgtttgctg gcttaagtct cttgtcatta gttgtattga
     2101 tggcctgtgg tgaggaagaa actaaaaaga ctcaagcagc acaacagcca aaacaacaaa
     2161 cgactgtaca acaaattgct gttggaaaag atgctccaga cttcacattg caatccatgg
     2221 atggcaaaga agttaagtta tctgatttta agggtaaaaa ggtttacttg aagttttggg
     2281 cttcatggtg tggtccatgc aagaaaagta tgccagagtt gatggaacta gcggcgaaac
     2341 cagatcgtga tttcgaaatt cttactgtca ttgcaccagg aattcaaggt gaaaaaactg
     2401 ttgagcaatt cccacaatgg ttccaggaac aaggatataa ggatatccca gttctttatg
     2461 ataccaaagc aaccaccttc caagcttatc aaattcgaag cattcctaca gaatatttaa
     2521 ttgatagcca aggaaagatt ggaaagattc aatttggtgc tatcagtaat gcggatgcag
     2581 aagcagcatt taaagaaatg aactagaatc gataaaatct gattacaaga tgtagtcaga
     2641 ttttggtaac ttctaaaact aacttccagt ttcccacaac ctagctttta gtatgagaaa
     2701 aacgcgtgac atcagtggaa atccgtctta gactaacttc cactggtttt ctttttcttg
     2761 atatataagg gttcaaaagc gaaaagactc agaaaaagtg cacgacaaat agccctaaaa
     2821 cagagtcgtc ttagagtaac ttccagtttt gggagagaga tggaagttac tttgagaagt
     2881 tacggtagtc agattttttt agaaaaacat tttataaata ttcacatatc tcctatattt
     2941 atggtaaaat agaattatca gtttattttg gagtcaaaga tgaatatatt tagaacaaag
     3001 aatgttagtt tagataaaac agagatgcat aggcatttga agttatggga tttgattttg
     3061 ctgggtatcg gagccatggt agggacaggc gtctttacaa tcacaggtac tgcagctgca
     3121 acacttgctg gcccagccct agtgatttca atcgttattt ctgccttgtg tgtgggatta
     3181 tcagccctct tttttgcaga atttgcctcg cgagtacccg ctacaggagg tgcctatagt
     3241 tacctctatg ctatcttagg agaattccct gcctggttgg ctggttggtt aaccatgatg
     3301 gagttcatga cagccatatc aggcgtagct tcgggttggg cagcttattt taaaggcttg
     3361 ctctctcaat acgggatagc ccttcctcag gctttaaatg gtacctttaa tcctcaagca
     3421 gggatatttg ttgatttatt gcctattctt gtcttggtct tggtgacttc gcttgtttta
     3481 ctaaatgcca aggcagcctt acgctttaat tcgattctag ttattttgaa attttccgct
     3541 ttagctctct ttgttttagt aggaatttgg aatattaagt ttgataattg gagcaatttt
     3601 gctccttacg gttttggaca aatctatgga gctagtactg gtattatggc tggtgcgtct
     3661 ttgatgttct tcggtttttt gggatttgaa tccatctcta tggctgtaga tgaagtcaag
     3721 actcctcaaa aaaatattcc tagagggatt gtcttatcgc tttctatcgt aaccattctc
     3781 tatgccttgg tgacccttgt tttgactggt gtggttcact atagtcattt aaatgtcgat
     3841 gatgccgttg cctttgccct tcgtagtgtt gggattagtt gggcagccaa ctatgtgtca
     3901 ttagtggcta tcttgacctt gattacagtt tgtatttcga tgacctatgc cctatcgcgt
     3961 atgatttaca gtttagcacg tgacggctta gtgcctgctg cctttaagga actgacgaag
     4021 actagcaaga taccaaagaa tgctactatc ttgacaggtc tagcttcagc agtagcagca
     4081 ggaatgttcc cactagccag tattgcagcc tttttaaata tttgtacctt agcctacttg
     4141 atcatgttgg cttatggtct gattcgctta cggaaagaaa aaggaatgcc caaagctggg
     4201 gaatttaaaa caccattggt acctctgtta ccaattttat cgatcatcat ttgtttatcc
     4261 ttcatgttac agtataatat gaatacctgg attgctttcc tagttgcgtt gttagtagga
     4321 agtattattt acttcactta tggctataag cattctacca tagaagaata aagtgaaagt
     4381 ctattgagtt gttgacactc agcagatttt tatatgtgaa agaaatttca aattttttct
     4441 aaaaatatct tgacagatta aattttcagg agtagaatat ttactagtta attaaatggt
     4501 taaggagttg ttcatgaaga aacaaaattt atttttagtc ctgttaagtg tctttctttt
     4561 gtgcttgggg gcttgtggtc aaaaggaaag tcagacagga aaggggatga aaattgtgac
     4621 cagtttttat cctatctacg ctatggttaa ggaagtatct ggtgacttga atgatgttcg
     4681 gatgattcag tcaagtagtg gtattcactc ctttgaacct tcggcaaatg atatcgcagc
     4741 catctatgat gcagatgtct ttgtttacca ttctcataca ctcgaatctt gggcaggaag
     4801 tctggatcca aatctaaaaa aatccaaagt gaaggtctta gaggcttctg agggaatgac
     4861 cttggaacgt gtccctggac tagaggatgt ggaagcaggg gatggagttg atgaaaaaac
     4921 gctctatgac cctcacacat ggctagatcc tgaaaaagct ggagaagaag cccaaattat
     4981 cgctgataaa ctttcagagg tggatagtga gcataaagag acttatcaaa aaaatgcgca
     5041 agcctttatc aaaaaagctc aggaattgac taagaaattc caaccaaaat ttgaaaaagc
     5101 gactcagaaa acatttgtaa cacaacatac agccttttct tatctagcga agagatttgg
     5161 gcttaatcaa cttggtattg caggtatctc tcctgaacaa gaaccaagtc cacgacaact
     5221 aacagaaatt caggaatttg ttaagaccta taaggttaaa acgattttta cagaaagtaa
     5281 tgcttcttca aaagtagctg aaactcttgt caaatcaaca ggtgtgggtc ttaaaactct
     5341 gaatccttta gagtcagacc cacaaaatga caagacctat ttagaaaatc ttgaagaaaa
     5401 tatgagtatt ctagcagaag aattaaagtg aggaaagaat gaaaattaat aaaaaatatc
     5461 tagcaggttc agtggcagtc cttgccctaa gtgtttgttc ctatgagctt ggacgttacc
     5521 aagctggtca ggataagaaa gagtctaatc gagttgctta tatagatggt gatcaggctg
     5581 gtcaaaaggc agaaaacttg acaccagatg aagtcagtaa gagggagggg atcaacgccg
     5641 aacaaattgt tatcaagatt acggatcaag gttatgtgac ctctcatgga gaccattatc
     5701 attactataa tggcaaggtt ccttatgatg ccatcatcag tgaagagctc ctcatgaaag
     5761 atccgaatta tcagttgaag gattcagaca ttgtcaatga aatcaagggt ggttatgtca
     5821 ttaaggtaaa cggtaaatac tatgtttacc ttaaggatgc agctcatgcg gataatattc
     5881 ggacaaaaga agagattaaa cgtcagaagc aggaacgcag tcataatcat aactcaagag
     5941 cagataatgc tgttgctgca gccagagccc aaggacgtta tacaacggat gatgggtata
     6001 tcttcaatgc atctgatatc attgaggaca cgggtgatgc ttatatcgtt cctcacggcg
     6061 accattacca ttacattcct aagaatgagt tatcagctag cgagttagct gctgcagaag
     6121 cctattggaa tgggaagcag ggatctcgtc cttcttcaag ttctagttat aatgcaaatc
     6181 cagctcaacc aagattgtca gagaaccaca atctgactgt cactccaact tatcatcaaa
     6241 atcaagggga aaacatttca agccttttac gtgaattgta tgctaaaccc ttatca
//
LOCUS       DAVHIZ010000074         6188 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.076, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000074 DAVHIZ010000000
VERSION     DAVHIZ010000074.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6188)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6188)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6188
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.076"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            127..3228
                     /locus_tag="VVO18_001847"
     CDS             127..3228
                     /locus_tag="VVO18_001847"
                     /EC_number="2.7.7.7"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000561528.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA polymerase III subunit alpha"
                     /protein_id="HEU5586941.1"
                     /translation="MIAQLDTKTVYSFMESVISIEKYVRAAKEYGYTHLAMMDIDNLY
                     GAFDFLEITKKYGIHPLLGLEMTVFVDDQEVNLRFLALSSVGYQQLMKLSTAKMQGEK
                     TWSVLSQYLEDIAVIVPYFDRVESLELGCDYYIGVYPETLASEFHHPILPLYRVNAFE
                     SRDREVLQVLTAIKENLPLREVPLRSRQDVFISASSLEKLFQERFPQALDNLEKLISG
                     ISYDLDTSLKLPRFNPARPAVEELRERAELGLVQKGLTSKEYQDRLDQELSVIHDMGF
                     DDYFLVVWDLLRFGRSNGYYMGMGRGSAVGSLVSYALDITGIDPVEKNLIFERFLNRE
                     RYTMPDIDIDIPDIYRPDFIRYVGNKYGSKHAAQIVTFSTFGAKQALRDVLKRFGVPE
                     YELSAITKKISFRDNLKSAYEGNLQFRQQINSKLEYQKAFEIACKIEGYPRQTSVHAA
                     GVVISDQDLTNYIPLKYGDEIPLTQYDAHGVEASGLLKMDFLGLRNLTFVQKMQELLA
                     EIEGIHLKIEEIDLEDKETLDLFASGNTKGIFQFEQPGAIRLLKRVQPVCFEDVVATT
                     SLNRPGASDYINNFVARKHGQEEVTVLDPVLEDILAPTYGIMLYQEQVMQVAQRFAGF
                     SLGKADILRRAMGKKDASAMHEMRVSFIQGSLEAGHTVEKAEQVFDVMEKFAGYGFNR
                     SHAYAYSALAFQLAYFKTHYPAIFYQVMLNSSNSDYLIDALEAGFEVASLSINTIPYH
                     DKIANKAIYLGLKSIKGVSNDLALWIIENRPYSNIEDFIAKLPENYLKLPLLEPLVKV
                     GLFDSFEKNRQKVFNNLANLFEFVKELGSLFGDAIYSWQESEDWTEQEKFYMEQELLG
                     IGVSKHPLQAIASKAIYPITPIGNLSENSYAIILVEVQKIKVIRTKKGENMAFLQADD
                     SKKKLDVTLFSDLYRQVGQEIKEGAFYYVKGKIQSRDGRLQMIAQEIREAVAERFWIQ
                     VKNHESDQEISRILEQFKGPIPVIIRYEEEQKTIVSPHHFVAKSNELEEKLNEIVMKT
                     IYR"
     gene            3311..4318
                     /gene="pfkA"
                     /locus_tag="VVO18_001848"
     CDS             3311..4318
                     /gene="pfkA"
                     /locus_tag="VVO18_001848"
                     /EC_number="2.7.1.11"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000820836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phosphofructokinase"
                     /protein_id="HEU5586942.1"
                     /translation="MKRIAVLTSGGDAPGMNAAIRAVVRQAISEGMEVFGIYDGYAGM
                     VAGEIHPLDAASVGDIISRGGTFLHSARYPEFAQLEGQLKGIEQLKKHGIEGVVVIGG
                     DGSYHGAMRLTEHGFPAIGLPGTIDNDIVGTDFTIGFDTAVTTAMDAIDKIRDTSSSH
                     RRTFVIEVMGRNAGDIALWAGIATGADEIIIPEAGFKMEDIVASIKAGYECGKKHNII
                     VLAEGVMSAAEFGQKLKEAGDTSDLRVTELGHIQRGGSPTARDRVLASRMGAHAVKLL
                     KEGIGGVAVGIRNEKMVENPILGTAEEGALFSLTAEGKIVVNNPHKADIELSSLNKSL
                     S"
     gene            4377..5882
                     /gene="pyk"
                     /locus_tag="VVO18_001849"
     CDS             4377..5882
                     /gene="pyk"
                     /locus_tag="VVO18_001849"
                     /EC_number="2.7.1.40"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008809276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate kinase"
                     /protein_id="HEU5586943.1"
                     /translation="MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAK
                     LIEAGANTFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEGE
                     AKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVLVDDGKLGLRV
                     VAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIA
                     ISFVRTAKDVNEVRAICEETGNGHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMG
                     IEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGT
                     DATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVK
                     DATNSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTD
                     APSSTDDMFEIAERKAIEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR"
BASE COUNT         1930 a         1064 c         1381 g         1813 t
ORIGIN      
        1 aaaatgatga caaaaataca aatgaataga aaataaatta gtaagctgat gaaatttttc
       61 tcaagagaag ccatttatag gtgaaaatgg tataatatag tgagaaggat agaggagaag
      121 tgtaaattga tcgcacaact agatacaaaa acagtctata gttttatgga aagcgtcatt
      181 tcgatcgaaa agtatgtgag agcagctaaa gaatacggct acactcattt ggctatgatg
      241 gatattgaca atctttatgg cgctttcgac tttctagaga ttacaaaaaa atacggcatt
      301 catcctttgc tagggcttga aatgacagtg tttgtagatg atcaggaagt gaatttgcgc
      361 tttttagctc tatctagtgt gggctatcag cagttgatga agctttcgac agccaagatg
      421 cagggggaga aaacttggtc agtcctgtcc cagtacctgg aggatatcgc ggtcattgtg
      481 ccttattttg atagagttga gtcgttagaa ctaggctgtg attactatat aggggtttat
      541 ccagaaacac tagcaagcga atttcatcat cctatcttac ctctttatcg ggtcaacgct
      601 tttgaaagca gggatagaga agttcttcaa gttttaacag cgattaaaga aaatctaccg
      661 ctcagagaag ttcccttgcg ttcgagacaa gatgtcttta tatcagcaag ttctttagag
      721 aaactattcc aagagcgttt tccgcaagct ttggacaatt tagaaaagct tatttcaggc
      781 atttcttacg acttggatac tagtctgaaa ctgcctcgtt ttaatccagc tagaccagca
      841 gtagaggagt tgagagagcg tgctgaactg gggcttgttc agaaggggtt gactagtaaa
      901 gaatatcaag atagactaga ccaagaattg tctgttattc atgatatggg ctttgatgat
      961 tatttcttgg ttgtttggga tttgttgcgt tttggacgat cgaatggcta ttatatggga
     1021 atgggaaggg gttctgcagt aggcagtttg gtttcttatg ccttagacat cacggggatt
     1081 gacccagtag agaaaaatct gatttttgaa cgctttctta atcgtgaacg ctataccatg
     1141 cctgatattg atattgatat cccagatatt tatcgtccag attttatcag atatgttggt
     1201 aataaatatg gtagtaaaca tgcggcacaa atcgttactt tttcaacctt tggagccaag
     1261 caagctcttc gagatgtctt gaaacgcttt ggtgtgccag agtatgaatt atctgcaatt
     1321 actaagaaaa tcagttttcg tgacaatctt aagtcggcct atgagggcaa tctccagttt
     1381 cgtcagcaaa tcaatagtaa gttagaatac caaaaagctt ttgagattgc ttgcaagata
     1441 gagggctatc caagacaaac ctctgtccat gcggctggtg ttgtaattag tgaccaagat
     1501 ttaaccaact atattcctct aaagtatggt gatgaaattc cactgactca gtatgatgct
     1561 catggagttg aggctagcgg acttttgaag atggactttc tgggactacg aaatttgacc
     1621 tttgtccaga agatgcaaga gttgcttgct gaaatagaag gtattcacct taaaattgaa
     1681 gaaatagatt tggaagacaa agaaacgtta gatttatttg cctctggaaa tacaaaaggt
     1741 atctttcaat ttgagcaacc aggtgccatt cgtctgctta agcgtgtgca accagtctgt
     1801 tttgaagatg tcgtcgcgac tacttctcta aatcgaccgg gtgctagtga ctatatcaat
     1861 aattttgtgg caagaaagca tgggcaggaa gaagtgactg ttctggatcc agtactggag
     1921 gatattttgg ctccaaccta cggcataatg ctctatcagg agcaggttat gcaggttgcc
     1981 cagcgatttg ccggatttag tcttgggaaa gccgatattt tgcgtcgggc tatggggaaa
     2041 aaggatgcct ctgccatgca tgagatgagg gtttccttta ttcaaggttc attagaagct
     2101 ggtcatactg tggaaaaagc agagcaggtc tttgatgtta tggagaagtt tgcaggttat
     2161 ggttttaaca ggtcacacgc ctatgcctac tcagccttgg ccttccagtt ggcttatttt
     2221 aaaacacatt atccagccat tttttatcag gtcatgttaa attcttccaa cagtgattac
     2281 ttaatagatg cacttgaagc aggttttgaa gtagcctctc tatccatcaa caccattccc
     2341 tatcacgata aaattgccaa caaggccatc tatctaggtt tgaaatccat taaaggagtc
     2401 agtaatgatt tagctctctg gattattgaa aatagacctt attctaacat tgaagatttt
     2461 atagctaaat tacctgagaa ttatctgaaa cttcctctgc tagaaccttt ggtaaaagtt
     2521 ggtcttttcg attcatttga aaaaaatcgt caaaaagtat ttaataattt agctaatcta
     2581 tttgaatttg tgaaagagtt gggaagtttg tttggagatg ctatttatag ttggcaggaa
     2641 tcggaagatt ggacggaaca agaaaaattt tatatggaac aagagctttt agggataggt
     2701 gtcagcaaac atccactaca agctattgca agtaaggcta tttacccgat taccccaatc
     2761 ggaaatttgt cagaaaatag ctatgctatt atcttggttg aagttcagaa aataaaagtg
     2821 attcgtacca aaaagggtga aaatatggcc ttcttacagg cagatgatag taagaaaaaa
     2881 ttggatgtca ctctcttttc agacttatat cgtcaggttg gacaggaaat aaaagaggga
     2941 gccttctact atgtaaaagg aaaaatacaa tcacgtgatg gccgtctgca aatgattgca
     3001 caagaaataa gagaagcagt tgctgaacgc ttttggatac aggtgaaaaa tcatgaatcg
     3061 gatcaagaaa tttcacgcat tttagaacaa tttaaaggcc caatcccagt catcatccgg
     3121 tatgaagagg aacagaaaac catcgtttct ccccatcatt ttgtagctaa atccaatgaa
     3181 ttagaggaga aattgaatga aatcgttatg aaaacgattt atcgctaaaa atacggaaaa
     3241 tagaagaatt ttaaaatcaa atgtgatata atcaagaaga atgttaaaag aaaaaggagc
     3301 ataaaccaat atgaaacgta ttgctgtttt gactagtggc ggagacgcac ctggtatgaa
     3361 cgctgccatc cgtgcagttg ttcgtcaagc aatttcagaa ggaatggaag tgtttggtat
     3421 ctatgacgga tatgctggta tggttgccgg tgaaattcat cccctagatg cagcttcagt
     3481 aggggacatc atttctcgtg gtggtacttt tcttcactca gctcgttatc cagagttcgc
     3541 tcaacttgaa gggcaactta aagggattga gcaattgaaa aaacacggaa ttgaaggtgt
     3601 agttgttatc ggtggtgacg gatcttacca cggcgctatg cgtttgactg aacatggctt
     3661 cccagctatt ggtcttccag gtacaatcga taacgatatc gttggtactg actttacaat
     3721 cggttttgac acagcggtta ctactgccat ggacgctatc gataagattc gtgatacatc
     3781 atcaagtcac cgtcgtactt ttgtaatcga agttatggga cgtaacgctg gtgatatcgc
     3841 tctttgggct ggtattgcaa ctggtgctga tgaaatcatc atccctgaag caggcttcaa
     3901 gatggaagat atcgtagcaa gcatcaaagc tggttatgaa tgtggtaaaa aacacaatat
     3961 catcgtctta gctgaaggtg tgatgtcagc ggctgaattt ggtcaaaaac ttaaagaagc
     4021 tggagataca agcgaccttc gtgtaacaga acttggacat attcaacgtg gtggttctcc
     4081 aactgcgcgt gaccgtgttt tggcgtcacg tatgggtgca catgctgtta aacttcttaa
     4141 agaaggtatc ggtggtgttg cggttggtat tcgtaacgaa aaaatggttg aaaatccaat
     4201 tcttggtact gcagaagaag gggcattgtt tagccttact gcagaaggta agattgtggt
     4261 taacaacccg cacaaagccg atattgagct atctagcttg aataagagct tgtcataatt
     4321 tacaatttag ttaataagac caaaaaggtc atatatataa aggagtcaca aaaatcatga
     4381 acaaacgtgt aaagatcgtt gcaactttgg gtcctgcggt agaaatccgt ggtggtaaaa
     4441 aattcggtga ggatggatac tggggtgaaa aacttgatgt tgaagcttca gctaaaaaca
     4501 ttgctaaatt gattgaagct ggtgctaaca cattccgatt caacttctca cacggcgacc
     4561 accaagaaca aggtgagcgt atggcaactg ttaaacttgc ggaaaaaatt gcaggtaaaa
     4621 aagttggttt ccttcttgat acaaaaggac ctgaaatccg tacagaattg ttcgaaggtg
     4681 aagctaaaga atattcatac aaaactggtg aaaaaattcg tgttgcaact aaacaaggaa
     4741 tcaaatcaac tcgtgaagtg attgcgttga acgttgctgg tgctcttgat atctatgatg
     4801 atgttgaagt tggtcgtcaa gttttggttg acgatggtaa acttggtctt cgtgtggttg
     4861 ctaaagatga tgcaactcgt gaatttgaag ttgaagttga aaacgatggt atcatcgcta
     4921 aacaaaaagg tgtgaacatc cctaacacta aaattccttt cccagctctt gctgaacgcg
     4981 ataacgacga tatccgtttc ggtcttgaac aaggtatcaa cttcatcgca atttcattcg
     5041 tacgtactgc aaaagatgtg aacgaagttc gtgcaatctg tgaagaaact ggaaacggac
     5101 atgttcaatt gttcgctaaa atcgaaaacc aacaaggtat cgataactta gacgaaatca
     5161 tcgaagcagc tgatggtatt atgattgctc gtggtgatat gggtatcgaa gtaccgttcg
     5221 aaatggttcc agtttatcaa aaaatgatta tcaagaaagt caatgctgca ggtaaagttg
     5281 ttatcactgc aacaaacatg cttgaaacaa tgactgaaaa accacgtgca actcgttcag
     5341 aagtatcaga cgtattcaac gctgttatcg acggaactga cgctacaatg ctgtcaggcg
     5401 agtctgcaaa cggtaaatac ccactcgagt cagtaactac aatggctaca atcgacaaga
     5461 acgctcaagc tcttcttaat gaatacggac gtcttgattc agattcattt gagcgtaact
     5521 ctaagacaga agtaatggct tctgctgtta aagatgctac taactcaatg gatatcaaat
     5581 tggttgtaac tcttactaag acaggtcata ctgcacgttt gatttctaaa taccgtccaa
     5641 atgctgacat cttagcattg acatttgacg aattgacaga acgtggcttg atgttgaact
     5701 ggggtgttat cccaatgttg acagatgctc catcttcaac tgacgatatg ttcgaaatcg
     5761 ctgaacgtaa agcgatagaa gcaggtctcg ttgagtcagg cgatgatatc gttatcgttg
     5821 ctggtgtgcc agtaggagaa gctgttcgca caaacacaat gcgtatccgc acagtacgtt
     5881 aagaaaaata taaaaaccta tcatatccag ctttagagct tgtgtgatag gttttttgta
     5941 tagagggtaa caaagaggca aaactttcat aatcgattga aataagatat gcacaaattg
     6001 attagaaagt caaatgaatt tctacaaatg ttttagcaat cgtaatgtac ttgtctagat
     6061 tcgatctgat atattttcga tttaatgata tggtatttaa aacctccaaa gtagcttgct
     6121 ccattctttt acttacgtga gtgtagatgt tatttactgt tttagcgttt ttgtgttcca
     6181 ctctaacc
//
LOCUS       DAVHIZ010000075         6064 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.077, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000075 DAVHIZ010000000
VERSION     DAVHIZ010000075.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 6064)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6064)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6064
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.077"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            32..275
                     /locus_tag="VVO18_001850"
                     /pseudo
     CDS             32..275
                     /locus_tag="VVO18_001850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000779614.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide pyrophosphohydrolase"
     gene            379..1128
                     /locus_tag="VVO18_001851"
     CDS             379..1128
                     /locus_tag="VVO18_001851"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000819180.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="HEU5586944.1"
                     /translation="MKRFEVSTEIGSLSVTYQKQKKVLVCLNGAGLLPSYENFSLILE
                     KPPPTIGYLTIDFPNTGRSPIHDQAGKNLDNLADAVYEVLEELGISEYILCAHSWSGI
                     LACKLLEKPIKRQTLVAIEPTTKKVMFADFSENPYPEMEEQMRLIDECGPELYFKNLT
                     QATFSPETNKKIWELMQEKGLELENQDPEFQISGEITEEDFENLSIESHVPVFIFCQT
                     YREKEYRESEYWTSNTKLILGRNHHYLQWSE"
     gene            1198..1716
                     /gene="rimM"
                     /locus_tag="VVO18_001852"
     CDS             1198..1716
                     /gene="rimM"
                     /locus_tag="VVO18_001852"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465641.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosome maturation factor RimM"
                     /protein_id="HEU5586945.1"
                     /translation="MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGAELALFDEK
                     DQFVQTVTIASHRKQKNFDIIKFKDMYHINTIEKYKGYSLKVAEEDLNDLDDGEFYYH
                     EIIGLEVYEGDSLVGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLNVDIPNKRV
                     DVEILEGLDDED"
     gene            1706..2425
                     /gene="trmD"
                     /locus_tag="VVO18_001853"
     CDS             1706..2425
                     /gene="trmD"
                     /locus_tag="VVO18_001853"
                     /EC_number="2.1.1.228"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tRNA (guanosine(37)-N1)-methyltransferase TrmD"
                     /protein_id="HEU5586946.1"
                     /translation="MKIDILTLFPEMFSPLEHSIVGKAREKGLLDIQYHNFRENAEKA
                     RHVDDEPYGGGQGMLLRAQPIFDSFDAIEKKNPRVILLDPAGKQFDQAYAEDLAQEEE
                     LIFICGHYEGYDERIKTLVTDEISLGDYVLTGGELAAMTMIDATVRLIPEVIGKESSH
                     QDDSFSSGLLEYPQYTRPYDYRGMVVPDVLMSGHHEKIRQWRLYESLKKTYERRPDLL
                     EHYQLTVEEEKMLAEIKENKE"
     gene            2437..2775
                     /locus_tag="VVO18_001854"
     CDS             2437..2775
                     /locus_tag="VVO18_001854"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196050.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586947.1"
                     /translation="MQVIKRNGEIAEFNPDKIYQAILKAAQTVYVLTDDLRQNLAQVT
                     KKVVLDLQEAKVERATISMIQSMVEHRLLGAGYITIAEHYISYRLQRDLERSGYGDHI
                     AVHLHFEQIR"
     gene            complement(2806..3126)
                     /locus_tag="VVO18_001855"
     CDS             complement(2806..3126)
                     /locus_tag="VVO18_001855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001216095.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586948.1"
                     /translation="MRHKFQQVLDKIHDFLNGHDQPDQTETNSLTATIEEAIQKQTAV
                     HLILSETSFTGDIIKYDQQGQQIIVKNFAKNVSRIIRISDIQRLRFVPSTVQTAQKNR
                     FKKE"
     gene            3224..3439
                     /locus_tag="VVO18_001856"
     CDS             3224..3439
                     /locus_tag="VVO18_001856"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807422.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdbC family protein"
                     /protein_id="HEU5586949.1"
                     /translation="MAEFTFEIEEHLLTLSENEKGWTKEINRVSFNGAPAKFDIRAWS
                     PDHTKMGKGITLSNEEFQTMVDAFKGN"
     gene            complement(3508..3588)
                     /locus_tag="VVO18_001857"
                     /pseudo
     CDS             complement(3508..3588)
                     /locus_tag="VVO18_001857"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001820552.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-galactopuranose mutase"
     gene            complement(3644..4180)
                     /locus_tag="VVO18_001858"
     CDS             complement(3644..4180)
                     /locus_tag="VVO18_001858"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000709035.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="biotin transporter BioY"
                     /protein_id="HEU5586950.1"
                     /translation="MKKAHVYAIPAIGAALIAVLAQISLPIGPVPFTLQNFAIGLIAT
                     VFRPREAVLSAGLYLLLGAIGLPVFAGGGAGFQALVGPTAGYLWFYLVYSGLTSSLTN
                     SKSGVVKIFLANLLGDALVFVGGILSLHFLAGMAFEKALVVGVLPFIIPDLGKLLAIS
                     FISRPLLQRLKNQAYFTN"
     gene            4606..4944
                     /locus_tag="VVO18_001859"
     CDS             4606..4944
                     /locus_tag="VVO18_001859"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746107.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586951.1"
                     /translation="MKKRINKKASVFLVASVFSFSFATTASVVNAVTAHPAPSPIIDV
                     WEYGVNDNYGYSNYFVSSPSNIGSKSSVTNFWGTVKAQDKKDYGWAYSSATKSWNDVR
                     LNAYWDYYRF"
     gene            5010..>6064
                     /locus_tag="VVO18_001860"
     CDS             5010..>6064
                     /locus_tag="VVO18_001860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000768915.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5586952.1"
                     /translation="MKLKLCIIGFFFCLIATIGLVTISDTEIPIPLPIDGAFSIQGKS
                     NLSNNEIYEMVRDLSKTEKVTIYKPIVQSSGQLKYVNFDDVNNEQLKSAPIVGMYYTL
                     GKMDVDSLKPLTMTGLQTVYMAYPWYIGGILQFTGTLRILLMGSIYLTLLVVLFVVRT
                     RQIKEGVIRRSLGLPIYDLRREYGISLIFELIMMALLMISYSSFLGNGFFTYSSKLFF
                     SLLLTNFILFQIIDLITFVLFWLTIQIEKPIEIIKNKAKNKLIFVVWLAIISIIILVS
                     GVFLQETKSSQSSINIQIQNLVPWDTVKDWRRIEFLGIESNSTKNREVNDSDGQYLQI
                     VAALKNLDFLYIERSSA"
BASE COUNT         2021 a          970 c         1252 g         1821 t
ORIGIN      
        1 acagcagtct cggactgatg aaggtctctt tatgaagtta gtggaggaag tcggagaagt
       61 agccgaggtt ttgaataggc gctctggtcg aaaagaaggg ataggattcg aacgaggaac
      121 ttgccagaga actggctgat atcatttact acaccgtcgc aatcgtagct attaatcata
      181 ttgaccttac caagactgtc tttgagaaag acaaaaccgc agccgttaat taccaacata
      241 aacatgattt ggaaggattt ttgaagggaa agtagagatg ttgtcccctt cctccaactt
      301 gagaaaatcc ttggaacgtg ataaaataaa agataaggat ttttaataat tcattatata
      361 gaatgagtgg atttctttat gaagaggttt gaagtatcta cagaaattgg tagcctctct
      421 gttacttatc aaaagcaaaa gaaagtgcta gtttgtctaa acggagcagg tttgctacca
      481 agttatgaaa atttttcact tatacttgaa aaacctcctc ctacaattgg ttatttgaca
      541 attgattttc cgaacacagg taggagtccg attcatgacc aagctggaaa aaatctagat
      601 aatcttgcag atgcggttta tgaagtactt gaagaattag gaatttctga atatatactt
      661 tgtgcacata gttggagtgg aattttagct tgcaaattac tcgagaaacc aattaagcgt
      721 cagactttag tagcaattga accgacaact aaaaaagtca tgtttgctga tttttcagaa
      781 aatccttatc cagaaatgga agagcagatg aggctgattg acgagtgtgg tcctgaactt
      841 tattttaaga acttaactca agcaacattt agtcctgaaa cgaataaaaa aatctgggaa
      901 ttaatgcaag aaaaaggctt agagttggaa aatcaagatc cagaatttca gatatctgga
      961 gagattactg aggaagattt tgagaatttg tcgatagaat ctcatgtccc tgtatttatt
     1021 ttttgtcaga cttatagaga aaaagagtac agagaatcag aatattggac ttccaatact
     1081 aaactcattt taggaaggaa tcaccattat ttacaatggt cagaatagga aaaaattgcg
     1141 gctattattc gagaattgtc agaataagat ggaaaaaagg agattacagg agacaagatg
     1201 aactacttta atgttgggaa aatcgttaat acgcagggat tacagggtga gatgcgagtc
     1261 ttgtctgtga cggattttgc agaagaacgg tttaaaaaag gagctgagct ggctttgttt
     1321 gatgaaaaag atcagtttgt ccaaacagtg accatcgcta gccaccgtaa acagaagaac
     1381 tttgacatta ttaaattcaa agatatgtac catatcaata ctatcgaaaa gtacaaggga
     1441 tacagtctca aggtcgctga ggaagatttg aatgacctag acgatggtga attttactat
     1501 cacgagatta tcggtttgga agtctatgag ggtgatagct tggttggaac catcaaggaa
     1561 atcctgcaac caggtgctaa tgatgtctgg gtggtcaaac gaaaaggcaa acgtgatttg
     1621 cttttacctt atatcccacc agtggttctc aatgttgata ttccaaataa acgggtcgat
     1681 gtggaaatct tagaagggtt agacgatgaa gattgatatt ttaaccctct ttccagagat
     1741 gttttctcca ctggagcact caatcgttgg aaaggctcga gaaaaagggc tcttggatat
     1801 ccagtatcat aattttcgag aaaatgctga aaaggcccgt catgtagatg atgagcccta
     1861 cggaggcggt cagggcatgt tgctcagagc acaacctatt ttcgattcct ttgatgctat
     1921 tgaaaagaaa aatccgcgcg ttattctcct cgatcctgct ggaaagcagt ttgatcaggc
     1981 ttatgctgaa gatttggctc aagaggaaga gctaatcttt atctgtgggc actatgaggg
     2041 ttatgatgag cgcattaaga ccttggtaac agatgagatt tccctaggcg actatgtcct
     2101 cactggtgga gaattggcag ctatgaccat gattgatgct acagttcgcc tgattccaga
     2161 agtgattggc aaggagtcta gccaccaaga tgatagtttt tcttcaggtc ttttagaata
     2221 tcctcagtac acacgtccct atgattatcg aggcatggtc gtgccagatg tattgatgag
     2281 tggccaccat gaaaagattc gtcagtggcg attgtacgag agtttaaaga aaacctacga
     2341 gcgcagaccg gatttacttg aacattatca actgacagta gaagaagaaa aaatgctggc
     2401 agaaatcaaa gaaaacaaag aataaaggag aaacctatgc aagtaatcaa acgtaatggc
     2461 gaaattgctg aatttaatcc agataagatt taccaagcca tcttgaaggc agcccaaact
     2521 gtttatgttt tgacagatga tttgcgtcaa aatcttgctc aagtcactaa gaaggtagtt
     2581 ttggatttac aagaagccaa ggtggaacgt gcgactatca gtatgattca atctatggtt
     2641 gaacatcgtt tattgggcgc aggttacatt accattgcag aacactacat ttcctatcgt
     2701 ttacaacgtg acttggaaag aagtggttat ggagatcata ttgcagttca tttacatttt
     2761 gaacaaattc gctaagaaaa aagagtggga tgaagcaact acatctcact ctttcttaaa
     2821 tctatttttt tgggctgttt ggacagttga ggggacaaat cgcaggcgtt gaatatcgct
     2881 tatacggata atccggctca catttttggc aaaatttttc acgataattt gctggccttg
     2941 ctgatcatat ttgatgatat cacctgtaaa acttgtctca gacaagataa ggtgaacagc
     3001 ggtttgtttc tggatagcct cttcaatagt ggctgtaagg gagttggttt cagtctggtc
     3061 aggttggtca tgtccattta aaaaatcatg tattttatct agaacttgct ggaatttatg
     3121 tctcatattg gcctcccttc ttttatatca atattatata aaattttcct aaaatctaca
     3181 agattttacg aataaactaa tgaaactaaa aaaggagaag aaaatagcag aatttacatt
     3241 tgaaatcgaa gagcacttgt tgactctttc tgaaaacgaa aaaggttgga ccaaggaaat
     3301 taaccgtgtg agctttaatg gtgcccctgc aaagtttgat attcgtgctt ggagtccaga
     3361 ccatactaaa atgggcaaag ggattactct ctcaaatgaa gaatttcaaa cgatggtgga
     3421 tgcctttaaa ggcaactaat actcttcgaa aatctcttca aaccgcatca gctttgcctt
     3481 gccgtatgta tggttactga cttcgtcagt ttcatccaca acctcaaaac agtgttttga
     3541 gcagcctgcg gctagcttcc tagtttgctc tttgattttc attgagtata agttttcaaa
     3601 ataaaaaaaa ggatattgag tcatgataac tcggtatcct tttttagtta gtaaagtaag
     3661 cctgattttt aaggcgttga agtaggggac ggctaataaa actaatagcc agaagtttgc
     3721 caaggtctgg aatgataaag ggaagaaccc ccacaacaag agctttttca aatgccattc
     3781 cagctaggaa atgcaagctg agaatcccgc cgacaaagac aagggcatca cccaagaggt
     3841 ttgcaagaaa aatcttaaca acaccactct tgctgttggt tagagaggaa gtaagtccag
     3901 agtaaacgag ataaaaccaa agatagcctg cagtagggcc aactaaagcc tgaaaaccag
     3961 ctccacctcc tgcaaagaca ggaagaccga tagcacctag aagaagatag agtccagcag
     4021 aaagtacagc ctctctcggt ctaaagacag tagcaatcaa gccgattgca aagttttgca
     4081 gagtgaaggg aacaggtcca attggaagac tgatttgtgc caaaacagca atgagagcag
     4141 ccccaatagc agggatagca taaacgtgag cttttttcaa aatagttaac ctcttttcta
     4201 atgtatagta actattatac tcatatagga gtcgatgtca accatttttt aaaaacaagg
     4261 taacaaaaac tgtaacagcc gattttcgtg actagtcaag ttggataatt tttttgttga
     4321 ttcgaaaatt gtctgtatag ataatcctat tttattaata aaaaatatac tagtaaatac
     4381 ttgacaaatt aaaaaataag tgttacatta aaaatgtaaa cggatacatt tagatgtgtt
     4441 caattttaaa aggaggggta gttatgagat attttaacga ctctagatac cataacggtg
     4501 attaaaaacc taaatataat caattcatat taaagtaata tggagggact aaaaagagac
     4561 tattatttaa tcttcatcaa atatttaaat tcaaggagaa gtaaaatgaa aaaaagaatt
     4621 aataagaaag catctgtttt tctagttgca agtgttttca gttttagctt tgctactaca
     4681 gctagtgtcg ttaacgcagt aacggcacac cctgctccaa gtcccattat tgatgtatgg
     4741 gaatatggtg taaatgataa ctatggttat tcgaattact ttgttagttc tccaagtaat
     4801 attggatcaa aatcttcagt aacgaatttt tggggaacag ttaaagctca ggataaaaaa
     4861 gattatggat gggcatattc aagtgcaaca aaatcttgga acgatgttcg cttaaatgca
     4921 tattgggatt attatagatt ttaaaaataa tttatgaaaa caagagaccc aattataaga
     4981 ttgggtctct tgtaatatgg taattgctta tgaaattaaa attatgtatc attggattct
     5041 tcttttgttt gattgctaca attggtctgg tcactattag tgataccgaa atccccatac
     5101 ctttaccaat tgatggagct ttttctatcc aaggaaaaag taatctttct aataacgaaa
     5161 tatacgaaat ggttcgtgac ttatcaaaaa cggaaaaggt taccatttac aagccaatcg
     5221 ttcagagttc gggtcagttg aagtatgtaa attttgatga tgtaaataat gaacaattaa
     5281 agtcagcacc aatagtaggg atgtattaca cacttgggaa aatggatgta gacagtttga
     5341 aaccacttac gatgacggga ctacaaacag tctatatggc ttatccttgg tatataggag
     5401 gaatattaca attcactgga actttaagaa tactgttaat gggttcaatt tatttaactt
     5461 tattagttgt tttatttgtt gttaggacga ggcagatcaa agaaggagtg atacgacgtt
     5521 ctttgggctt gcctatatac gacttaagaa gagagtatgg catttctctt atttttgaac
     5581 tgattatgat ggctttattg atgatttctt acagttcttt tttgggtaat ggtttcttca
     5641 cctatagttc taagttattt ttctctctgc ttttaacgaa ttttatacta tttcaaatca
     5701 ttgatcttat tacttttgtt ttgttttggt tgacgattca gattgaaaag cctattgaaa
     5761 ttattaaaaa caaggcaaaa aacaagctta tttttgtcgt atggcttgct attatttcga
     5821 ttatcatcct tgtctcagga gtttttttac aagaaacaaa gagtagtcaa tctagtatta
     5881 acatacagat acagaattta gtaccatggg atacagtaaa agactggaga aggattgagt
     5941 tccttggaat tgaaagtaac tctactaaaa atagagaagt taatgattca gatggtcagt
     6001 atctacagat agttgctgcc ttaaaaaact tagatttctt atatatagaa cggtcttcag
     6061 cata
//
LOCUS       DAVHIZ010000076         5689 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.078, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000076 DAVHIZ010000000
VERSION     DAVHIZ010000076.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5689)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5689)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5689
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.078"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            117..281
                     /locus_tag="VVO18_001861"
     CDS             117..281
                     /locus_tag="VVO18_001861"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="HEU5586953.1"
                     /translation="MGIIANVFAGLVGAYAGQSLLGSWGPSIAGMALLPSIVGAAIVI
                     TVVSFFTGRK"
     gene            365..931
                     /gene="amaP"
                     /locus_tag="VVO18_001862"
     CDS             365..931
                     /gene="amaP"
                     /locus_tag="VVO18_001862"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030212.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alkaline shock response membrane anchor protein
                     AmaP"
                     /protein_id="HEU5586954.1"
                     /translation="MSKAKKICFIIFCILILTIFLPVLIDYHQVSDLGIHLLSWRQNS
                     VVEFYLARYVFWGTVVLSTLVLLSILVVMFYPKRYLEIQLETKNDTLKLKNSAIEGFV
                     RSLVSDHRLIKNPTVHVNLRKNKCFVHVEGKILPSDNIADRCQIIQNEITNGLKQFFG
                     IERQVKLEVAVKNYQPKPQNKKTVSRVK"
     gene            943..1113
                     /locus_tag="VVO18_001863"
     CDS             943..1113
                     /locus_tag="VVO18_001863"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000455065.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2273 domain-containing protein"
                     /protein_id="HEU5586955.1"
                     /translation="MEWLKQYRYPIIAGLIGVFLACLIVSFGFFKTIFVLILGALGVA
                     AGLYIEKNYIDK"
     gene            1152..1760
                     /locus_tag="VVO18_001864"
     CDS             1152..1760
                     /locus_tag="VVO18_001864"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000064115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="HEU5586956.1"
                     /translation="MSNEKNTNTNVEKKDATVVAHEIKGELTYEDKVIQKIIGLSLEN
                     VSGLLGIDGGFFSNLKEKIVNSDDVTSGVNVEVGKTQVAVDLNVIVEYQKNVPALYSE
                     IREIVSSEVAKMTDLEIVEINVNVVDIKTKEQHEADSVSLQDRVSDVAESTGEFTSEQ
                     FEKAKSGLGSGFSTVQEKVSEGVEAVKGAANGVVSHENTRVN"
     gene            1791..1994
                     /locus_tag="VVO18_001865"
     CDS             1791..1994
                     /locus_tag="VVO18_001865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398938.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CsbD family protein"
                     /protein_id="HEU5586957.1"
                     /translation="MSVEEKLNQAKGSIKEGVGKAIGDEKMEKEGAAEKVVSKVKEVA
                     EDAKDAVEGAVEGVKNMLSGDDK"
     gene            complement(2104..2376)
                     /locus_tag="VVO18_001866"
                     /pseudo
     CDS             complement(2104..2376)
                     /locus_tag="VVO18_001866"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012514870.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(2521..2967)
                     /locus_tag="VVO18_001867"
     CDS             complement(2521..2967)
                     /locus_tag="VVO18_001867"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000155432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586958.1"
                     /translation="MTIRFEEKVSIENAQLVCQWSNSLGKVFQEQWMGPRIPFPLTLQ
                     ALEGVFSIFDEQEFVGLIQKIRLEDSNLHIGRFFINPQKQEQDLGSQALRKFVSLAFE
                     NEDIDSISLNVFEANQRAQNLYQKEGFEIVQMVEAPVRKYSRLKLE"
     gene            3037..3696
                     /locus_tag="VVO18_001868"
     CDS             3037..3696
                     /locus_tag="VVO18_001868"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000564993.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="prepilin peptidase"
                     /protein_id="HEU5586959.1"
                     /translation="MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLR
                     PLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLGLLFLLYSWELLSLGQVVLITAG
                     LTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
                     FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLL
                     V"
     gene            complement(3748..4899)
                     /locus_tag="VVO18_001869"
     CDS             complement(3748..4899)
                     /locus_tag="VVO18_001869"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481741.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="HEU5586960.1"
                     /translation="MFNGRVLKELRLLNGLSRAELAQRINLTEQAIWQFESNETKPKL
                     STKMHLANQFHVDLTYFEQEEESIRFDSSVIAFRNADLATRKTIDIQTMYLHKVDSLI
                     DYFESFIIIPNIIIHDLSNVVSESYHKGESIEELALYAREKLGISKDNHDLLYKLERS
                     GIYIVERLINGQADAYSAWSKLGRPYIVLGTNKSSVRRNFDLAHELGHILLHKYKDMN
                     EDGDRLEQEANYFASCFLLPKEEFLVKFEERVGKRVSNPDSYILLKSDLNVSIQALEY
                     RAFKLGLLTPKQHSYFYRQIAQKGYKMIEPLDDQIFVKKPSKVKSILDVVLSNHLVSL
                     ATIMSKQSIRLQFISEIFSVEMKFFDQYQEDRRTDRFDNIIPLYKRNNL"
     gene            complement(4914..5645)
                     /locus_tag="VVO18_001870"
     CDS             complement(4914..5645)
                     /locus_tag="VVO18_001870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586961.1"
                     /translation="MLNQDLFDSLEAQKIVDTLMKGQKDYVDERLEKRETMIVSNGYA
                     WTRPNHIDTAFASADLFEYKLQLAGQTWGYLEFETNTEKYGKVLLIIKGKKRLTNQFP
                     LVQKNKSGYLFEYAQMNTLYLNQHSSYKNDEDSHSFPIQMELVSDEMIQEIEQATKNS
                     NIEKFMILTYEADSENNIISVDVVMPDARTGQLHLIQDLSEYIQSSSYHFEEAKYQDI
                     PNFSELSETEDFEIIPRIEKQEGQK"
BASE COUNT         1759 a         1032 c          956 g         1942 t
ORIGIN      
        1 aagaaattga ttttttgata ttaaaataaa aaaggagggt aggcagtgtt gtgatcaatt
       61 attgctggag gtcttattgg tctcttggta ggtaaaatca ctaaaaaagt agttctatgg
      121 gaatcatcgc aaatgtattc gctggtttag tcggggcata tgcaggacaa tctcttttag
      181 gtagttgggg tccatcaatc gctggaatgg ctttgctccc atctattgta ggtgcagcga
      241 ttgtgattac tgtagtgtca ttctttacag gtagaaagta aacttttcgc cagtaaagtt
      301 agcaaactat ttttaaatca atgacgggaa aaatagttta aatgttaaat cgaaaggatt
      361 gtatatgtca aaagcaaaga aaatatgttt cattattttc tgtattttaa tcttgacaat
      421 tttccttcct gttttgatag attatcatca agttagtgat ctaggtattc atctacttag
      481 ctggagacag aactccgtag ttgaattcta tcttgctaga tatgtctttt gggggacagt
      541 ggttctatca actttagttt tattatccat tttagttgtg atgttttatc ctaaacgtta
      601 cttggaaatc caacttgaaa ctaaaaacga tacattaaaa ttaaagaatt cggcaatcga
      661 aggttttgtt agaagtttgg tgagtgatca tagattgatc aagaacccaa ctgttcatgt
      721 aaatttacga aaaaataaat gtttcgttca tgtagaaggt aaaattcttc cttcagacaa
      781 catcgctgac agatgccaaa taattcaaaa tgaaataact aatggattga agcagttttt
      841 tggtattgag cgtcaagtaa aacttgaagt tgcagtaaaa aattaccaac caaaacctca
      901 aaacaaaaag actgttagtc gtgtgaagta aggaagtaaa aaatggaatg gcttaaacaa
      961 tatcgatatc caattatcgc tggtctcata ggcgtatttc tggcttgttt gattgtctcc
     1021 tttggcttct tcaaaacaat atttgtattg attttaggag cactgggagt tgcagctgga
     1081 ttatatatcg aaaaaaacta tatagataaa taaaaaaata aaaattacta atttaattaa
     1141 aggagtttca tatgtcaaac gaaaaaaaca caaacactaa cgtagaaaag aaagatgcta
     1201 ctgttgtagc tcacgaaatc aaaggggaac ttacttacga agataaagtt atccaaaaaa
     1261 tcattggtct ttcactagaa aacgtttcag gtcttttggg aatcgatggt ggtttcttct
     1321 caaatcttaa agaaaaaatc gttaacagcg atgacgtaac aagtggtgtt aacgtagaag
     1381 ttggtaaaac acaagttgca gttgacttaa acgttattgt tgagtaccaa aaaaatgttc
     1441 cagctttata ttcagaaatc agagaaatcg tatcttcaga agttgctaaa atgactgact
     1501 tggaaattgt tgaaatcaac gtaaacgttg tcgacatcaa aactaaagaa cagcatgaag
     1561 cagactcagt aagccttcaa gatcgcgtat ctgacgttgc tgaatcaaca ggagaattca
     1621 cttcagaaca attcgaaaaa gctaaatctg gtcttggatc tggtttctca actgttcaag
     1681 aaaaagttag cgaaggtgta gaagctgtta aaggtgcagc aaatggtgta gtatctcacg
     1741 aaaacactcg tgtaaactaa gataaaataa atataacagg agaaattatc atgtcagtag
     1801 aagaaaaatt aaatcaagct aaaggttcta ttaaagaagg tgttgggaaa gccatcggtg
     1861 atgaaaaaat ggaaaaagaa ggagcagctg aaaaagttgt ttctaaagta aaagaagttg
     1921 ccgaagacgc taaagacgct gtagaaggtg ctgtagaagg tgttaaaaac atgttgagtg
     1981 gcgacgataa ataaggttaa aagttacttt atctttttgg taacattagt caaaagagtc
     2041 tgagtcaaga tgattctcag aaaacaaaaa gctagagatt cccaattgcg gaactctagc
     2101 tttttaattt tgcctctttc tcttattata tttcagcagg ttgttggcca tgagtatgaa
     2161 tcccatgtca attctcactt gacgcttacc tctcagatga catctcttat aacccaaaca
     2221 aacctttatc tgcccaaaga cagatttcat atcaatctta cgtttagcga aaatttgtct
     2281 acccttggaa gataaaagtg cctgatattc tttagttttt aaacactggt aacgttcatt
     2341 catatacagt cccttttgag gggctgattc aggttcataa tcgcagtcaa cattgatttc
     2401 aaggctgttt gctttctatc tccccttttt cataatgtat agtaaaatga aataataaca
     2461 ggacgaatcg atcgggacag tcaaatcgat ttctaacaat gttttagaag cagaggtgta
     2521 ctattctagt ttcaatctac tatattttcg tacaggtgct tcaaccattt gaacaatttc
     2581 aaatccttct ttttggtaaa gattctgagc tctttgattt gcctcgaaga catttagaga
     2641 aatactatct atatcttcat tttcaaaggc caaactaaca aatttcctta aagcctggct
     2701 acctaagtct tgctcctgtt tctgggggtt gataaaaaat ctcccgatat gaagattgct
     2761 gtcttctagc ctgattttct ggataagtcc cacaaactct tgttcatcaa agattgaaaa
     2821 gactccttcc aaggcttgaa gggtcagtgg aaaaggaatc cttggtccca tccattgttc
     2881 ttgaaagact ttgcctaagg agttggacca ttggcatacg agctgagcgt tttctatact
     2941 caccttttct tcaaaacgaa ttgtcatctt ttcctcacca tcttatctat gtttctccat
     3001 tatactattt ctcccatttt ttacgaatag ataagtatga ttgattttta tttttttctc
     3061 gtcgggagca ttctcgcttc ctttcttggt ttggtcattg accgttttcc agagcaatcc
     3121 attatcagtt cagccagtca ctgcgattcc tgtcagactc gcttgcgtcc cttagatttg
     3181 attccgattc tctcacaggt cttcaatcgc tttcgctgtc gctactgcaa agttcgctat
     3241 cctgtctggt atgccctctt tgaattagtc ttaggactcc tctttctgct ttactcttgg
     3301 gaattgcttt ccttggggca agtcgtccta atcaccgctg gtttgacctt gggtatctac
     3361 gactttcacc atcaggaata tcccttactg gtctggatga ctttccacct aatcctaata
     3421 gcttcctctg gctggaatct ggtcatggtc tccttccttg ctcttggaat tttggctcat
     3481 tttatcgata tccgcatggg cgcaggagat ttcctctttt tagcttcttg tgctctcgtc
     3541 tttagcgtaa cggagttact gatcttgatt cagtttgctt ctgcgacggg tatcctggcc
     3601 tttatcctgc aaaagaaaaa ggaaagactt cctttcgtgc ctttcctctt acttgctact
     3661 tgtttgatta tttttggtaa gctactgctt gtttgataaa gtccaatttc tgccatatgt
     3721 ccttcatgaa attatttcac agttaaatta taaattattt cttttgtaca aagggatgat
     3781 gttatcaaat cgatctgttc ttctatcttc ttgatactga tcaaaaaatt tcatttcgac
     3841 tgaaaatatt tcgcttataa actgtaaacg aatactttgt ttagacatta tagtcgctag
     3901 actgactaga tgattactca aaacgacgtc cagaatactc tttactttgc ttggtttttt
     3961 aacaaaaatt tgatcatcca aaggttcaat cattttgtaa cctttttgcg caatttgacg
     4021 ataaaagtaa gaatgttgct ttggagtcaa taatcctaac ttaaaagctc gatactctaa
     4081 agcctgtatc gaaacattca aatccgactt caataaaata taactatcag gattgctgac
     4141 acgcttgcca accctctctt caaatttgac taaaaactct tcttttggca ataaaaaaca
     4201 tgatgcaaaa taatttgctt cttgctccaa acgatcgcca tcttcattca tatctttata
     4261 tttatgtaaa agaatatgtc ctagctcatg agctaagtca aaatttcgac gtacagatga
     4321 tttattcgtt cccaacacaa tataaggtct tcccaatttt gaccatgcgc tataagcatc
     4381 agcttggcca ttaattaatc gttccacgat atagatgcct gaacgttcta atttataaag
     4441 caaatcatga ttatcttttg aaatacctaa tttttccctg gcataaagag ccaattcctc
     4501 aatggattct cccttatgat aagattcact cactacatta cttaggtcat gaattataat
     4561 attaggtata attataaaac tttcaaaata atcaatcaaa ctatctacct tatgtaaata
     4621 catagtttga atatctattg ttttccgtgt tgctaggtct gcatttctaa aggcaattac
     4681 agaagaatca aatcgaatgc tctcttcttc ctgttcaaaa taagttaaat caacatgaaa
     4741 ttggttggcc aaatgcattt tggttgataa tttaggtttc gtttcgttgg actcaaactg
     4801 ccaaatggct tgttccgtta aattaattct ctgagctaat tctgctctac ttaaaccatt
     4861 taacagccgt aattctttca atacccgacc attaaacatt tacatactcc ttactacttt
     4921 tgaccttctt gtttttctat tcttggaata atttcaaaat cttctgtttc cgataattct
     4981 gaaaaattag gaatatcttg atatttagct tcttcgaaat ggtacgaact tgattgaata
     5041 tactcagaca aatcttgaat caagtgtaac tgaccagttc gtgcatcagg cataacaaca
     5101 tctacagata taatattgtt ttctgagtcc gcctcataag ttaaaatcat aaatttttcg
     5161 atattcgaat ttttagtagc ttgttcaatt tcttgaatca tttcatcaga aactaactcc
     5221 atctgaattg gaaaggaatg actatcttca tcatttttgt aggaagaatg ttgattaaga
     5281 taaagtgtat tcatctgagc gtattcaaat aagtagccac tcttattttt ttgtaccaaa
     5341 ggaaattggt tcgtaagtcg cttcttaccc tttataatta acaatacttt cccatatttt
     5401 tctgtatttg tttcaaattc taaatatccc caagtctgtc ctgctaattg taatttatac
     5461 tcaaacaaat ctgctgatgc aaatgcagta tcaatatgat taggtcgcgt ccatgcataa
     5521 ccattcgaca ctatcattgt ctctcttttt tctagacgtt catctacata atctttttgc
     5581 cctttcatca aagtatctac aattttttgt gcctcaagcg aatcaaagag atcctgattc
     5641 aacataattc ttcctcctcc aaatactttt taatgaatta tatcatttt
//
LOCUS       DAVHIZ010000077         5382 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.079, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000077 DAVHIZ010000000
VERSION     DAVHIZ010000077.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5382)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5382)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5382
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.079"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            25..684
                     /locus_tag="VVO18_001871"
     CDS             25..684
                     /locus_tag="VVO18_001871"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000793810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1868 domain-containing protein"
                     /protein_id="HEU5586962.1"
                     /translation="MKNLTKIKFKENGEFNHFPGNTVVANLYTKQDLMEVVDIIQSRY
                     RELPFIDKFTLTPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEI
                     FPLLDEEIHMRVTEMGKQNILVEPADEASAKRLEEIRTYVSEKAGVRFPNHDRYQFHI
                     SIGYLRIPLTEEEEEEFTKVRAELTEILLEKIPTITVNRIDYTVFEDMRQFVPYHEKF
                     K"
     gene            709..1776
                     /locus_tag="VVO18_001872"
     CDS             709..1776
                     /locus_tag="VVO18_001872"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000738359.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU5586963.1"
                     /translation="MKKMKVWSTVLATGVALTTLAACSGGSNSTTASSSEEKADKSQE
                     LVIYSNSVSNGRGDWLTAKAKEAGFNIKMVDIPGAQLADRVIAEKNNAVADMVFGIGA
                     VDSNKIRDQKLLVQYKPKWLDKIDQSLSDKDNYYNPVIVQPLVLIGAPDVKEMPKDWT
                     ELGSKYKGKYSISGLQGGTGRAILASILVRYLDDKGELGVSEKGWEVAKEYLKNAYTL
                     QKGESSIVKMLDKEDPIQYGMMWGSGALVGQKEQNVVFKVMTPEIGVPFVTEQTMVLS
                     TSKKQALAKEFIDWFGQSEIQVEYSKNFGSIPANKDALTELPEDTKKFVDQVKPQNID
                     WEAVGKHLDEWVEKAELEYVQ"
     gene            1879..2889
                     /locus_tag="VVO18_001873"
     CDS             1879..2889
                     /locus_tag="VVO18_001873"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586964.1"
                     /translation="MIKFDNIQIKYGDFVAIDNLNLDIHEGEFFTFLGPSGCGKSTTL
                     RALVGFLDPSSGSIEVNGTDVTHLEPEKRGIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VAPDVIKAKVSAVAAKIKISDQQLQRNVSELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVDLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGYIEQVGTPV
                     EIYHNSQTEFVCDFIGDINVLTDETVHEVLLKNTSVFLEDKKGYIRLEKVRFNRETEQ
                     DFILKGTIIDVEFSGVTIHYTIKVSENQILNVTSIDSQAAIRSVGESVELFITPSDVL
                     QF"
     gene            2901..4592
                     /locus_tag="VVO18_001874"
     CDS             2901..4592
                     /locus_tag="VVO18_001874"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861837.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU5586965.1"
                     /translation="MRHKLNLKDWLIRLGLIWFLVTFIIYPNFDLVVNVFVKGGEFSL
                     DAVHRVLKSQRALQSIMNSFKLAFSLIITVNVVGILCVLFTEYFDIKGAKILKLGYMT
                     SLIYGGVVLATGYKFVYGPYGLITKFLQNVIPSLDPNWFIGYGAVLFIMTFSGTANHT
                     LFLTNTIRSVDYHTIEAARNMGAKPFTVFRKVVLPTLIPTLFALTIMVFLSGLSAVAA
                     PMIVGGKEFQTINPMIITFAGMGNSRDLAALLAIILGIATTILLTIMNKIEKGGNYIS
                     ISKTKAPLKKQKIASKPWNIIAHIVAYGLFTVFMLPLIFIVLYSFTDPVAIQTGNLTL
                     SNFTLENYRLFFSNSAAFSPFLVSFIYSIIAATTATILAVVFARVVRKHKARFDFLFE
                     YGALLPWLLPSTLLAVSLLFTFNQPQFLVLNQILVGSLVILLIAYIVVKIPFSYRMVR
                     AILFSVDDEMEDAARSMGASPFYTMMKVIIPFILPVVLSVIALNFNSLLTDFDLSVFL
                     YHPLAQPLGITIRSAGDETATSNAQALVFVYTIVLMIISGTVLYFTQRPGRKVRK"
     gene            4595..5305
                     /locus_tag="VVO18_001875"
     CDS             4595..5305
                     /locus_tag="VVO18_001875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127555.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HEU5586966.1"
                     /translation="MTATSLGLSNIEIVVRIVLSVVIGSIIGLERGSKSQPAGIRTYS
                     IVCLAACLIMMTNEYVSYKFGTGDPTRLGAQVISGVGFLGAGTILITDKKKITGLTTA
                     AGIWASAGIGLAIGVGFYEGALLVAISVWGVISMFQPLKKYLQNRSKMIELYIVVKST
                     EAYNRVLVYCAENGIRMTDSRTAFGDVNSDRIEYFDVPDKKIASFITLELSGRFEHLR
                     LMEEIANIVGVIYVEEIS"
BASE COUNT         1767 a          761 c         1031 g         1823 t
ORIGIN      
        1 aaatataaaa aagagggtct ttatatgaaa aacctaacaa aaattaagtt caaagaaaat
       61 ggagaattta atcattttcc aggaaatact gttgtagcaa atctttatac taaacaagat
      121 ttgatggaag ttgttgatat tattcaatca cgttatagag aattaccatt tatcgataag
      181 tttactttaa ctccaaggaa ttctattcac atgactgtaa ttgaattgtt gtgccatgaa
      241 aatcgtgaaa cggagttttg gagcagtaat cttcctcttg atacaccttt acaggaaata
      301 catgattact ttgctaaaca acttgaaatt tttccattgt tggatgaaga aattcatatg
      361 cgtgtgactg aaatgggaaa acaaaacata ctagttgaac ctgcagatga agcttctgca
      421 aagagattag aagaaattcg tacttatgtt tcagaaaaag caggtgttcg tttccctaat
      481 catgatagat accaattcca tatttcaatt ggatatcttc ggattcctct aaccgaagag
      541 gaggaagaag agtttactaa agtcagagca gaattaactg aaattttatt agagaagatt
      601 ccaactatta ctgtaaaccg tattgactat actgtatttg aagatatgag acaatttgtt
      661 ccatatcacg aaaaatttaa ataaaataat aaaaaaggag aactgatcat gaaaaaaatg
      721 aaagtttggt ctactgtact tgcaacggga gttgctctta ctacacttgc tgcttgctct
      781 ggaggttcaa attctacgac tgcttcttca tctgaagaaa aagctgataa aagtcaagaa
      841 ttagtaatct attcgaactc agtctcaaat ggtcgtggtg attggttaac tgctaaagca
      901 aaagaagctg gttttaatat caaaatggtt gatatccctg gcgctcaatt agcagaccgt
      961 gttattgctg agaagaataa tgcagttgca gatatggtat ttggaattgg tgctgttgat
     1021 tcaaataaaa ttagagatca aaaattacta gtacagtaca agcctaaatg gttagataaa
     1081 attgatcaat ctttatcaga taaagataat tattataatc ctgtgattgt tcaaccatta
     1141 gttttaattg gggcgcctga tgtaaaagaa atgcctaaag attggacaga attaggtagt
     1201 aagtataaag gtaaatattc aatttctggt cttcaaggtg gtacaggacg tgcaattcta
     1261 gcaagtatct tagttcgata ccttgatgat aaaggtgaat taggtgtttc cgaaaaaggt
     1321 tgggaagtag caaaagaata tttgaaaaat gcatacactc ttcaaaaggg agaaagttca
     1381 attgttaaga tgttagacaa agaagatcca atacaatatg gaatgatgtg gggttctggt
     1441 gcattagttg gacaaaaaga acaaaatgtt gttttcaaag ttatgactcc tgagattggt
     1501 gtaccatttg taactgaaca aactatggtt ttaagcacta gtaaaaaaca agcgttagct
     1561 aaagaattta ttgattggtt tggtcaatca gaaattcaag tagaatatag taagaacttt
     1621 ggatctattc ctgcaaataa agatgcccta acagagttac ctgaagatac gaaaaaattt
     1681 gttgatcaag tgaaaccaca aaatattgac tgggaagctg ttggaaaaca tttggatgaa
     1741 tgggtagaaa aagctgaatt agaatacgta caataagaaa taagagttaa tttttatgtc
     1801 caagtctctc tattatttct aaatttatag aagaaataaa gagaggcttt tggtttagta
     1861 atagagggag ttagtgagat gattaaattt gataatattc aaattaaata tggtgatttt
     1921 gttgcaattg ataatctgaa tttagatata catgaagggg aattttttac atttcttggg
     1981 ccttcaggat gtggtaaatc aactactttg agagcattgg taggttttct agatccatca
     2041 tcaggaagta ttgaagttaa tggaacagat gtcactcatt tggaacctga aaagcgtgga
     2101 attggtattg tatttcaatc ttatgctcta tttccaacta tgactgtttt tgataatatt
     2161 gcatttggtt taaaagttaa gaaggtagct ccagatgtta ttaaagctaa agtatcagca
     2221 gtagcagcaa aaattaagat ctctgatcaa cagttacagc gtaatgtatc agaattatct
     2281 gggggtcaac aacaaagggt agcgttggct cgtgctctgg ttcttgaacc taaaattctt
     2341 tgtctagatg aaccattgtc aaaccttgac gcaaaattac gtgtagattt gagaaaagag
     2401 ttgaaaagac ttcaaaaaga gttaggtatt actactttat atgttactca tgatcaagag
     2461 gaagccttga ctctatctga tagaattgca gtctttaaca atggatacat cgaacaggtc
     2521 ggtacaccag tagagattta tcataattct caaactgaat ttgtatgtga ttttattgga
     2581 gatattaatg ttttgaccga tgaaacagtc cacgaagtat tactgaaaaa tacaagcgtt
     2641 ttcttagaag ataaaaaagg atacattcga ttagagaaag ttcgattcaa tcgtgaaact
     2701 gaacaagatt ttattctaaa agggacgatt attgatgttg agttttctgg agttacaatt
     2761 cactatacaa taaaagtttc tgaaaatcag attcttaatg taacaagtat tgatagtcag
     2821 gctgctatta gatctgtcgg agaaagtgtg gaattattta tcacaccatc agacgttctg
     2881 caattttaag gaggtgcagt atgcgtcata aattaaattt aaaagattgg cttattcgtt
     2941 tagggttaat ctggttctta gtaacattta ttatttatcc aaactttgat ctagtagtga
     3001 atgtatttgt aaaaggagga gaattttccc ttgatgctgt acatcgtgtt ctaaaatctc
     3061 agagggcact tcagagtatt atgaacagtt ttaagttagc attttcactc attattacag
     3121 ttaatgtcgt aggtattctt tgtgttctat ttacagagta ctttgatatt aaaggtgcta
     3181 aaattttaaa attaggttat atgacctctt taatttatgg aggagtggtt ttagcgactg
     3241 gatataaatt tgtctatggt ccttatggat tgataacaaa atttttacaa aatgttatcc
     3301 cttctttaga ccctaactgg tttattgggt atggtgcagt cttattcatt atgacatttt
     3361 caggaactgc taatcataca ttgtttttaa caaatacaat tcgaagcgtt gactatcaca
     3421 ctattgaggc tgctcgaaat atgggagcaa aaccatttac tgttttccga aaagtagtgt
     3481 taccaacctt aattccaact ctatttgcac ttactattat ggtttttctt agtggtttat
     3541 ctgcagtagc agcacccatg attgttggtg gtaaagaatt tcaaactata aatccaatga
     3601 ttattacatt tgcagggatg gggaattctc gtgatttagc tgccctactt gcaattattt
     3661 taggtattgc aactacaatt ttgcttacta tcatgaataa gatagaaaaa ggtggaaatt
     3721 atatttctat ctctaagact aaagcgcctc ttaaaaaaca aaaaattgcg tctaagcctt
     3781 ggaatatcat tgctcacatt gtagcatatg gattgttcac agttttcatg cttccactaa
     3841 tttttatagt attatactca tttacagatc cagttgcaat tcaaacaggt aacttaacat
     3901 tatcaaactt tactttagaa aattatcgcc tattctttag taatagtgcg gcattctctc
     3961 cattcttggt cagctttatt tattctatta tcgctgcgac aacagcaaca attctcgcag
     4021 ttgtatttgc tcgagttgtc agaaaacata aagctcgttt tgatttttta tttgaatatg
     4081 gtgctctact tccttggtta ctaccaagta cacttttagc agtaagttta ttatttactt
     4141 ttaatcagcc acaatttctt gtcttgaatc agattttggt aggtagtttg gtaattctac
     4201 ttattgcata tatagttgta aaaatcccat tttcttatag aatggtacgt gctattttat
     4261 ttagtgttga tgatgagatg gaagatgcag caagaagtat gggtgcttca cctttttata
     4321 ctatgatgaa ggttatcatt ccatttattt taccggttgt tctctctgtt attgctttaa
     4381 actttaactc tttattaact gacttcgact tatctgtatt cctttaccat cccctagctc
     4441 aaccattagg tattacgatt cgatctgcag gtgatgaaac agcaacatct aatgcacaag
     4501 ctctggtatt tgtttataca attgttctga tgatcatttc tggaacggta ttatacttca
     4561 cacaaagacc ggggcgtaaa gtaaggaaat aatcatgaca gccactagtc ttgggttatc
     4621 aaatattgaa atagttgtca ggattgtttt atcagtagtc attggtagta taattggttt
     4681 agagagaggg agcaaatccc agcctgcagg catccgaact tatagtattg tttgtctagc
     4741 tgcatgtttg attatgatga cgaatgaata cgtatcttat aaatttggga caggagatcc
     4801 tacacgatta ggagctcaag ttatatcagg tgtgggtttt ctaggcgctg gaacgattct
     4861 tattacagat aaaaagaaaa ttacaggtct gacaactgca gcaggcattt gggcttcggc
     4921 aggaattgga ttagctattg gagtaggttt ttatgaggga gctcttttag tagccatttc
     4981 tgtttggggt gtgatatcca tgttccaacc actaaaaaaa tatctgcaaa atcgttctaa
     5041 aatgattgaa ttgtatatag tggttaaatc tacagaagcc tataatcgtg tattggttta
     5101 ttgtgcagaa aatggtatca gaatgaccga ttcaagaaca gcgtttggag atgttaattc
     5161 tgacagaatt gaatactttg atgttccaga taaaaaaata gcgtcattta ttactctgga
     5221 attatcaggt agatttgaac atcttcgact gatggaagaa attgctaata ttgtaggtgt
     5281 tatttatgtc gaagaaatta gctgaaattt agtaaacaaa gggacagatg tttttgtcct
     5341 tttgtttttt agatgtttta atcatctaat ttttgagtag at
//
LOCUS       DAVHIZ010000078         5234 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.080, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000078 DAVHIZ010000000
VERSION     DAVHIZ010000078.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5234)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5234)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5234
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.080"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(346..1074)
                     /locus_tag="VVO18_001876"
     CDS             complement(346..1074)
                     /locus_tag="VVO18_001876"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000105270.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GntR family transcriptional regulator"
                     /protein_id="HEU5586967.1"
                     /translation="MSTKYLFIYNEIREKILCNKYTMNEQLPDEMTLAKQFACSRMTI
                     KKALDLLVSEGLIFRKRGQGTFVLSRGSSKRKLIVPERDIRGLTKISEDAHSTIDSRI
                     IHFKLEFANEFLAEKLQVALQSPVYNIYRLRIIDGKPYVLEQTYMSTDVIPGITEDIL
                     QKSIYNYIEGKLGLHIASATKILRASSSSENEQHYLQLLPTEPVFEVEQVAYLDNGTP
                     FEYSISRHRYDLFEFNSFALRHSS"
     gene            1232..2641
                     /locus_tag="VVO18_001877"
     CDS             1232..2641
                     /locus_tag="VVO18_001877"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728302.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEU5586968.1"
                     /translation="MKKKLVFPNLFWWGAASSGPQTEGQYGKVHENVMDYWFKTHPED
                     FFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFY
                     NAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKV
                     HYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQVIYNLNLASAKVIQLYRSLELDG
                     KIGIILNLTPAYPRSNSPEDLEASRFTDDFFNKVFLNPAVKGTFPERLVKQLERDGVL
                     WSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRM
                     NPYRGWEIFPKSIYDIAMIVKEEYGNIPWFISENGMGVENEARFIDENGVIDDVYRIE
                     FYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKSS
                     GRWYRKVSDNNGFEVEIEE"
     gene            2659..3954
                     /locus_tag="VVO18_001878"
     CDS             2659..3954
                     /locus_tag="VVO18_001878"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000798148.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="HEU5586969.1"
                     /translation="MKNSKFIDQFATFAGKLGNQIHLKTLRDAFVTVMPLYILAGLIV
                     LLNNTVFKWIFQGDTLTRFQYWGITIANGTLSISGMIIAVMVGYFLAKNRDFENPLAA
                     SMLSLVSLIVMMPNTVSVVPDGAKDAVNISGVLSFNNTGTGAMFAGVIVAIIATELFI
                     ELSNVKALQMNLGENIPPAVSRSFSVLLPVMTVISLFGVVSALLFNITGMNLISIITI
                     FIQEPIRHIGTSLIGVIIIYSLGNMLWLFGIHQAVIYSAILEPLLLINITENITAANN
                     GQAIPHIINLSQIQTFALMGGSGSTLCLLIATFLVSRNAVSKNVAKLSFGPGIFNINE
                     PVLFGYPIVYNISLAIPFITVPVLGILISYLATVTGFMSPAFIQVPWTTPVFLNAWLA
                     TAGDVRAVLVQFIIFALGVLLYIPFIKVNDKVVEQEMEG"
     gene            3959..4267
                     /locus_tag="VVO18_001879"
     CDS             3959..4267
                     /locus_tag="VVO18_001879"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="HEU5586970.1"
                     /translation="MKQILLVCNAGMSTSMLVKKMQQSATERGIEISIQAKSMTEAKK
                     NIHEADVILIGPQIRYELLAVKEIAGNIPVDTIDMRDYGMMNGAKVLEQALAWIGEIR
                     "
     gene            4264..4572
                     /locus_tag="VVO18_001880"
     CDS             4264..4572
                     /locus_tag="VVO18_001880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="HEU5586971.1"
                     /translation="MTEEMEYICFQLIANSGAAKSSFIEAIQLAKAGNLKEAKIKVEE
                     AEDSLVEAHKIHSNLIQKEATGEKIGFSLLFMHAEDQMASTEIIQLLSKEFIDLYQNK
                     "
BASE COUNT         1766 a          880 c          946 g         1642 t
ORIGIN      
        1 tcatttctag caatttgtta gaagtcacag tctactattc taacctcagt atactatatg
       61 tgttacaaga aaagactcaa aaacttctcg tcagtgtaag aatatttgaa acactattta
      121 aaactaaata actataagaa gtagatcagg tgaacaattt cagtacctac tctataagct
      181 atacgaagat atttttcaac atgatggata aaacgatcac tcttttaaag ccatcttatt
      241 tagaaaagag aaaccattta agcatagatg ggaccttctt gccctgtttt aaatttttct
      301 taaactagag tctgtaaaag attggcttca ttttcacatt ttctcctagg aggaatgtcg
      361 taatgcaaaa gaattaaatt caaataaatc atagcgatga cgactaatcg agtactcaaa
      421 cggagttccg ttatccaaat aagccacttg ttctacttca aataccggtt ccgttggaag
      481 gagctgcaag taatgttgct cattttctga actagaagaa gctcgtaaga tttttgtagc
      541 actggcaata tgcaatccta actttccttc aatgtaattg taaatcgatt tttgtaaaat
      601 atcttcagta atacctggaa taacatcggt actcatataa gtttgttcca gaacataagg
      661 tttaccgtca ataatacgca ggcggtaaat attataaact ggactctgca aagcgacctg
      721 tagtttttct gctaaaaatt catttgcaaa ttctaatttg aagtgaataa tcctcgagtc
      781 aattgtagaa tgagcatctt cagatatttt tgtcagtccc cggatatctc tttctggaac
      841 gattaatttt ctttttgagc tgccacgaga gagaacaaag gttccctgcc cacgttttct
      901 aaaaattaag ccctcagaaa ctaacaagtc taaagctttt ttgatcgtca ttcgactaca
      961 ggcaaactgt ttagctaatg tcatttcatc aggtaattgt tcgttcatgg tatatttatt
     1021 acaaagaatc ttttcacgaa tctcattgta aataaataaa tattttgtac tcatttaatc
     1081 tggttctctc tataatattc taatagtagt ataacaaagt tcaagaaatg aggcaaacac
     1141 aagatatgta tcaacaattt ttaaaaatgt ctagacaaat tttaaaatta tgctatactt
     1201 tatgtataga ataatagaaa ggaggttgag catgaaaaaa aagttagtat ttcctaatct
     1261 gttttggtgg ggagcagctt ctagcggacc tcagacagaa ggtcaatatg gaaaagtaca
     1321 tgaaaatgtg atggactact ggttcaaaac gcatccagaa gattttttcg ataatgtcgg
     1381 acctcttgta gccagtaact tttttcatac ttacaccgaa gatttccact tgatgaagga
     1441 aattggagtt aattctttcc gcacttccat ccaatggagt cgactcatca agaatttaga
     1501 gacaggtgag cctgatccaa aaggtattgc tttctacaat gccatcattg aagaagctaa
     1561 aaagaaccag atggatcttg tgatgaattt acatcatttt gatttaccag tggaacttct
     1621 tcaaaaatac ggtggttggg aaagcaaaca tgtagtggag ttattcgtga agtttgccaa
     1681 gactgctttc acatgctttg gagataaggt tcattactgg acaactttca atgagccaat
     1741 ggtcattcca gaagcaggat acttatatgc tttccattat ccaaatctaa aaggaaaggg
     1801 aaaagaggcc gtacaagtca tctataatct aaaccttgct agtgcaaaag tgattcaact
     1861 atatcgctca ttagaacttg atggaaagat tgggattatt ttaaacttga cacctgctta
     1921 tccaagaagt aattctccag aagacttaga agcaagtcga tttacagatg acttctttaa
     1981 caaagtcttc ttgaatccag ctgttaaagg aactttccca gaaagattgg taaaacagct
     2041 agagagagat ggcgtgttat ggagtcatac cgaaaaagag cttcaactga tgaaatcaaa
     2101 tacggttgat tttcttggag taaactacta ccatccaaaa cgtgttcaag cacaagcaaa
     2161 tcctgaggaa tatcagacgc cctggatgcc agaccaatac ttcaaagagt atgaatggcc
     2221 ggagcgtcgc atgaatccat atcgtggttg ggaaattttt ccgaaatcca tttatgatat
     2281 tgctatgatt gtgaaggaag aatatggtaa tatcccatgg tttatcagtg aaaacggaat
     2341 gggtgttgaa aacgaagcac ggtttatcga tgaaaatgga gttatcgatg acgtgtatcg
     2401 tattgaattt tatgaagaac atttaagatg gctacataaa gccattgaag agggaagtca
     2461 ctgttttgga taccacgctt ggaccgcatt tgattgctgg tcttggaata atgcatataa
     2521 gaatcgttac ggatttatct ccgttgattt agaaacgcaa aagagaacca tcaagagctc
     2581 aggaagatgg tatcgcaaag taagtgacaa taacggtttt gaagtagaaa ttgaggagta
     2641 aagagaggag atattcatat gaaaaactca aaatttatag accaatttgc cacctttgct
     2701 ggtaaactag ggaaccaaat tcatttaaaa accctaagag atgcattcgt aacagtaatg
     2761 ccattatata ttttggcagg tttaatcgtt cttttgaaca acacggtatt taagtggatt
     2821 ttccaagggg atacattaac aagattccaa tattggggaa taacaattgc aaacggtact
     2881 ttaagtattt caggtatgat tattgctgta atggttggtt atttcttagc taaaaacaga
     2941 gatttcgaaa acccgttagc agcatcaatg ctatcattag tttctttaat tgtgatgatg
     3001 ccaaatacag tttctgtagt tcctgacgga gcaaaagatg ctgtaaacat ttcaggtgtt
     3061 ctttcattca acaacacagg tacaggcgca atgttcgccg gggttatcgt agcgattatt
     3121 gcaacagaat tattcattga attatcaaat gttaaagctt tacaaatgaa ccttggtgaa
     3181 aatattccac cagctgttag tagatcattt agcgtattac ttccagtcat gaccgtcatc
     3241 tccttatttg gggttgtttc agcattatta ttcaatataa ctggaatgaa cttaatctca
     3301 atcattacaa tctttattca agaaccaatt cgtcatattg gtacaagctt aatcggggtc
     3361 attattattt actctttagg aaatatgtta tggctatttg gtattcacca agcagttatt
     3421 tacagtgcca tcctagaacc attactatta attaacatta ctgaaaacat cactgcagca
     3481 aataatggac aagccattcc acacatcatc aacctatcac aaatacaaac attcgcttta
     3541 atgggtggta gtggatctac attatgttta ttaatagcaa cattcttagt gagtcgcaat
     3601 gctgtctcta aaaacgtggc taaattatct tttggacctg gtatcttcaa tatcaatgaa
     3661 ccagtattat tcggttaccc aatcgtttat aacatttcat tagctattcc atttatcaca
     3721 gttccagtcc ttggtatttt aatcagctac ttagcaacag ttacaggatt catgagtcct
     3781 gcatttatac aagttccttg gactacacca gtattcttaa atgcatggtt agcaacagca
     3841 ggggacgtga gagcagttct agttcaattc atcatctttg cacttggagt tcttctatac
     3901 attccattta tcaaagttaa tgacaaagtt gttgaacaag aaatggaagg ttaagattat
     3961 gaaacaaatt ttattagtat gtaatgcggg aatgtcgaca agtatgcttg ttaaaaaaat
     4021 gcaacaaagt gcgactgaac gtgggattga aatctctatc caagcaaaat caatgacaga
     4081 agctaaaaag aatatccatg aagcagatgt cattctaatt gggccacaaa ttcgttatga
     4141 gttacttgct gtgaaagaaa ttgcaggaaa tatccctgta gataccattg atatgcggga
     4201 ttacggaatg atgaatggag caaaagttct ggaacaagca cttgcatgga taggagaaat
     4261 aagatgacag aagaaatgga atatatctgt tttcagctca ttgccaatag tggagcagcc
     4321 aaatcatcct ttattgaagc catccaacta gctaaggcag gaaatttaaa agaagcgaaa
     4381 attaaagttg aagaagcgga agactcctta gtagaagcgc acaagattca ctctaatctc
     4441 atacaaaaag aagctactgg agaaaaaata ggattctcct tgctatttat gcatgcagaa
     4501 gaccaaatgg cttcaacaga gattattcag ttgctatcta aagaattcat cgatctctat
     4561 caaaataaat aggaacactg tcattcccat ctgtctttat taatgacgac tacattgtag
     4621 gaacctccaa aagttggaca aaatgattga aaggattgga tcctgcatta cacaagatcc
     4681 aatccttttc ttttactcta gtttttataa tatgttgaat ctagaatagt ccactgtagt
     4741 ttctaaaaaa ttgctggaaa tggatgttaa gctccaattt atttgtttat atcttatttc
     4801 agtttactat actagcttat tattctagtg aaaaattgaa tgagccacta tttatttaat
     4861 atgtatgatg agggaatgac tcaaaaactt cttgtcgata taagaatatc tgagatagta
     4921 ttttaaaacg aaaggactat aaaagctcat ttccttcgca cttattttat agagatctat
     4981 cattatactc tttagaaatc aaaaagcaac acaccttgtc atcgttttat cgtaaatctg
     5041 ttaatgaggg ggctagtctt atctgcaatc tcaaatcagt gttttgagct gaatggcact
     5101 cgttttctag tttgctcttt gattttaatt gggccttagt aaatactact cttaaattaa
     5161 actatagtga attgaaataa gatgtgaaca actctatcag aaaagtaaaa ttaatttcta
     5221 taaatgtttt agca
//
LOCUS       DAVHIZ010000079         5006 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.081, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000079 DAVHIZ010000000
VERSION     DAVHIZ010000079.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 5006)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5006)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5006
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.081"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..418
                     /locus_tag="VVO18_001881"
     CDS             <1..418
                     /locus_tag="VVO18_001881"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700331.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HEU5586972.1"
                     /translation="KNKVDQDSKPDEDKGHDEVSEPTHPESDEKENHAGLNPSADNLY
                     KPSTDTEETEEEAEDTTDEAEIPQVEHSVINAKIADAEALLEKVTDPSIRQNAMETLT
                     GLKSSLLLGTKDNNTISAEVDSLLALLKKSQPAPIQ"
     gene            628..3747
                     /gene="phtE"
                     /locus_tag="VVO18_001882"
     CDS             628..3747
                     /gene="phtE"
                     /locus_tag="VVO18_001882"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000672589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtE"
                     /protein_id="HEU5586973.1"
                     /translation="MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDG
                     SQSSQKSENLTPDQVSQKEGIQAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDALFSE
                     ELLMKDPNYQLKDADIVNEVKGGYIIKVDGKYYVYLKDAAHADNVRTKDEINRQKQEH
                     VKDNEKINSNVAVARSQGRYTTNDGYVFNPADIIEDTGNAYIVPHGGHYHYIPKSDLS
                     ASELAAAKAHLAGKNMQPSQLSYSSTASDNNTQSVAKGSTSKPANKSENLQSLLKELY
                     DSPSAQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPI
                     SGTGSTVSTNAKPNEVVSSLGSLSSNPSSLTTSKELSSASDGYIFNPKDIVEETATAY
                     IVRHGDHFHYIPKSNQIGQPTLPNNSLATPSPSLPINPGTSHEKHEEDGYGFDANRII
                     AEDESGFVMSHGDHNHYFFKKDLTEEQIKAAQKHLEEVKTSHNGLDSLSSHEQDYPSN
                     AKEMKDLDKKIEEKIAGIMKQYGVKRESIVVNKEKNAIIYPHGDHHHADPIDEHKPVG
                     IGHSHSNYELFKPEEGVAKKEGNKVYTGEELTNVVNLLKNSTFNNQNFTLANGQKRVS
                     FSFPPELEKKLGINMLVKLITPDGKVLEKVSGKVFGEGVGNIANFELDQPYLPGQTFK
                     YTIASKDYPEVSYDGTFTVPTSLAYKMASQTIFYPFHAGDTYLRVNPQFAVPKGTDAL
                     VRVFDEFHGNAYLENNYKVGEIKLPIPKLNQGTTRTAGNKIPVTFMANAYLDNQSTYI
                     VEVPILEKENQTDKPSILPQFKRNKAQENSKLDEKVEEPKTSEKVEKEKLSETGNSTS
                     NSTLEEVPTVDPVQEKVAKFAESYGMKLENVLFNMDGTIELYLPSGEVIKKNMADFTG
                     EAPQGNGENKPSENGKVSTGTVENQPTENKPADSLPEAPNEKPVKPENSTDNGMLNPE
                     GNVGSDPMLDPALEEAPAVDPVQEKLEKFTASYGLGLDSVIFNMDGTIELRLPSGEVI
                     KKNLSDLIA"
     gene            complement(3873..5006)
                     /locus_tag="VVO18_001883"
                     /pseudo
     CDS             complement(3873..5006)
                     /locus_tag="VVO18_001883"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         1799 a          814 c         1004 g         1389 t
ORIGIN      
        1 taaaaataag gtagaccaag atagtaaacc tgatgaagat aagggacatg atgaagtaag
       61 tgagccaact caccctgaat ctgatgaaaa agagaatcac gctggtttaa atccttcagc
      121 agataatctt tataaaccaa gcactgatac ggaagagaca gaggaagaag ctgaagatac
      181 tacagatgag gctgaaattc ctcaagtaga gcattctgtt attaacgcta agatagcaga
      241 tgcggaggcc ttgctagaaa aagtaacaga tcctagtatt agacaaaatg ctatggagac
      301 attgactggt ctaaaaagta gtcttcttct cggaacgaaa gataataaca ctatttcagc
      361 agaagtagat agtctcttgg ctttgttaaa aaaaagtcaa ccggctccga tacagtagta
      421 aaatgaatgg agcatatttt atggagaagt aacctttcgt gttacttctc ttttttagaa
      481 aaacgtaaca gaaacttgac aaaagtaatt ttaaatagta aactatttac tggttaatta
      541 aatggttaaa taaccggttt agaaaactat ttaataaagt aaaagaagtt gagaaaaaac
      601 ttcatcattt attgaaatga gggatttatg aaattcagta aaaaatatat agcagctgga
      661 tcagctgtta tcgtatcctt gagtctatgt gcctatgcac taaaccagca tcgttcgcag
      721 gaaaataagg acaataatcg tgtctcttat gtagatggca gccagtcaag tcagaaaagt
      781 gaaaacttga caccagacca ggttagccag aaagaaggaa ttcaggccga gcaaattgta
      841 atcaaaatta cagatcaggg ctatgtaacg tcacacggtg accactatca ttactataat
      901 gggaaagttc cttatgatgc cctctttagt gaagaactct tgatgaagga tccaaactat
      961 caacttaaag acgctgatat tgtcaatgaa gtcaagggtg gttatatcat caaggtcgat
     1021 ggaaaatatt atgtctacct gaaagatgca gctcatgctg ataatgttcg aactaaagat
     1081 gaaatcaatc gtcaaaaaca agaacatgtc aaagataatg agaagattaa ctctaatgtt
     1141 gctgtagcaa ggtctcaggg acgatatacg acaaatgatg gttatgtctt taatccagct
     1201 gatattatcg aagatacggg taatgcttat atcgttcctc atggaggtca ctatcactac
     1261 attcccaaaa gcgatttatc tgctagtgaa ttagcagcag ctaaagcaca tctggctgga
     1321 aaaaatatgc aaccgagtca gttaagctat tcttcaacag ctagtgacaa taacacgcaa
     1381 tctgtagcaa aaggatcaac tagcaagcca gcaaataaat ctgaaaatct ccagagtctt
     1441 ttgaaggaac tctatgattc acctagcgcc caacgttaca gtgaatcaga tggcctggtc
     1501 tttgaccctg ctaagattat cagtcgtaca ccaaatggag ttgcgattcc gcatggcgac
     1561 cattaccact ttattcctta cagcaagctt tctgccttag aagaaaagat tgccagaatg
     1621 gtgcctatca gtggaactgg ttctacagtt tctacaaatg caaaacctaa tgaagtagtg
     1681 tctagtctag gcagtctttc aagcaatcct tcttctttaa cgacaagtaa ggagctctct
     1741 tcagcatctg atggttatat ttttaatcca aaagatatcg ttgaagaaac ggctacagct
     1801 tatattgtaa gacatggtga tcatttccat tacattccaa aatcaaatca aattgggcaa
     1861 ccgactcttc caaacaatag tctagcaaca ccttctccat ctcttccaat caatccagga
     1921 acttcacatg agaaacatga agaagatgga tacggatttg atgctaatcg tattatcgct
     1981 gaagatgaat caggttttgt catgagtcac ggagaccaca atcattattt cttcaagaag
     2041 gacttaacag aagagcaaat taaggctgcg caaaaacatt tagaggaagt taaaactagt
     2101 cataatggat tagattcttt gtcatctcat gaacaggatt atccaagtaa tgccaaagaa
     2161 atgaaagatt tagataaaaa aatcgaagaa aaaattgctg gcattatgaa acaatatggt
     2221 gtcaaacgtg aaagtattgt cgtgaataaa gaaaaaaatg cgattattta tccgcatgga
     2281 gatcaccatc atgcagatcc gattgatgaa cataaaccgg ttggaattgg tcattctcac
     2341 agtaactatg aactgtttaa acccgaagaa ggagttgcta aaaaagaagg gaataaagtt
     2401 tatactggag aagaattaac gaatgttgtt aatttgttaa aaaatagtac gtttaataat
     2461 caaaacttta ctctagccaa tggtcaaaaa cgcgtttctt ttagttttcc gcctgaattg
     2521 gagaaaaaat taggtatcaa tatgctagta aaattaataa caccagatgg aaaagtattg
     2581 gagaaagtat ctggtaaagt atttggagaa ggagtaggga atattgcaaa ctttgaatta
     2641 gatcaacctt atttaccagg acaaacattt aagtatacta tcgcttcaaa agattatcca
     2701 gaagtaagtt atgatggtac atttacagtt ccaacctctt tagcttacaa aatggccagt
     2761 caaacgattt tctatccttt ccatgcaggg gatacttatt taagagtgaa ccctcaattt
     2821 gcagtgccta aaggaactga tgctttagtc agagtgtttg atgaatttca tggaaatgct
     2881 tatttagaaa ataactataa agttggtgaa attaaattac cgattccgaa attaaaccaa
     2941 ggaacaacca gaacggccgg aaataaaatt cctgtaacct tcatggcaaa tgcttatttg
     3001 gacaatcaat cgacttatat tgtggaagta cctatcttgg aaaaagaaaa tcaaactgat
     3061 aaaccaagta ttctaccaca atttaaaagg aataaagcac aagaaaactc aaaacttgat
     3121 gaaaaggtag aagaaccaaa gactagtgag aaggtagaaa aagaaaaact ttctgaaact
     3181 gggaatagta ctagtaattc aacgttagaa gaagttccta cagtggatcc tgtacaagaa
     3241 aaagtagcaa aatttgctga aagttatggg atgaagctag aaaatgtctt gtttaatatg
     3301 gacggaacaa ttgaattata tttaccatcg ggagaagtca ttaaaaagaa tatggcagat
     3361 tttacaggag aagcacctca aggaaatggt gaaaataaac catctgaaaa tggaaaagta
     3421 tctactggaa cagttgagaa ccaaccaaca gaaaataaac cagcagattc tttaccagag
     3481 gcaccaaacg aaaaacctgt aaaaccagaa aactcaacgg ataatggaat gttgaatcca
     3541 gaagggaatg tggggagtga ccctatgtta gatccagcat tagaggaagc tccagcagta
     3601 gatcctgtac aagaaaaatt agaaaaattt acagctagtt acggattagg cttagatagt
     3661 gttatattca atatggatgg aacgattgaa ttaagattgc caagtggaga agtgataaaa
     3721 aagaatttat ctgatctcat agcgtaagga atagcagtag aaaaagtctg aatcaaaaat
     3781 aaagttctct caaaagttag aaataaaact ctgactttgg gagaatttca ttttattagg
     3841 ctctttgtca actgtagtgg gttgaagaaa agctaagctt gagaaaggac aaatttcgtc
     3901 ctttcttttt tgatgttcag agcgatgaaa atccgttttt ttgaagtttt caaagttccg
     3961 aaaaccaaag gcattgcgct tgataagttt gatgagatta ttggtcgctt ccagtttggc
     4021 attagaatag tgtagttgaa gggcgttgac aatcttttct ttatctttga ggaaggtttt
     4081 aaagacagtc tgaaaaatag gatgaacctg ctttagattg tcctcaataa gcccgaaaaa
     4141 tttctctggt tccttattct ggaagtgaaa cagcaagagt tgatagagtt gatagtggtg
     4201 tttcaagtct tccgaatagc tcaaaagctt gtttaaaatc tctttattgg ttaagtgcat
     4261 acgaaaagta ggacgataaa aatgtttatc gctgagttta cgactatcct gttgaatgag
     4321 tttccagtag cgcttgatag ccttgtattc atgggatttt cgatgaaact gattcatgat
     4381 ttgaacacgc acacgactca tagcacggct aagatgttgt acaatgtgaa agcgatcaag
     4441 aacaattttt gcattcggga gtgaaacagt ctgggagact gtttcagcct gagcctagaa
     4501 atttgaaagc gaagctgttt agccaagtca tagtaagggc taaacatatc catagtaatg
     4561 attttgacgc gacatcggac aactctatcg tagcgaagaa agtgatttcg aatgatagct
     4621 tgtgttctac cctcaagaac agtgatgata ttgagattgt taaaatcttg cgcaatgaag
     4681 ctcatctttc cctttgtaaa agcatactca tcccaagaca taatctcagg aagacaagaa
     4741 aaatcatgtt taaagtgaaa atcattgagc tttcgaatga cagttgaagt tgaaatggcc
     4801 agctgatggg caatatcggt catagaaatc ttttcaatta acttttgcgc aatcttttgg
     4861 ttgataatac gaggaatttg gtgatttttc ttgacgatag aagtttcagc gaccatcatt
     4921 ttcaagcaat gatagcactt aaaacgacgt tttctaagga gaattctagt aggcatacca
     4981 gtcgtttcaa ggtaagggat cttaga
//
LOCUS       DAVHIZ010000080         4780 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.082, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000080 DAVHIZ010000000
VERSION     DAVHIZ010000080.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4780)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4780)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4780
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.082"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(130..201)
                     /locus_tag="VVO18_001884"
     tRNA            complement(130..201)
                     /locus_tag="VVO18_001884"
                     /product="tRNA-Arg"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(166..168),aa:Arg,seq:cct)
     gene            complement(243..590)
                     /gene="rplS"
                     /locus_tag="VVO18_001885"
     CDS             complement(243..590)
                     /gene="rplS"
                     /locus_tag="VVO18_001885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005590628.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L19"
                     /protein_id="HEU5586974.1"
                     /translation="MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFE
                     GVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRA
                     LQGKAARIKEIRR"
     gene            complement(709..1038)
                     /gene="crcB"
                     /locus_tag="VVO18_001886"
     CDS             complement(709..1038)
                     /gene="crcB"
                     /locus_tag="VVO18_001886"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237393.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEU5586975.1"
                     /translation="MVIVYLAIACGLGALVRYFFSRYNQASKLPLGTLIANLLGCFLI
                     GVFYNHVESKEVYAILATGFCGGLTTFSTLNDELQRLLSDKKVFYSYLTLTYIGGLVA
                     IFLGILL"
     gene            complement(1032..1406)
                     /gene="crcB"
                     /locus_tag="VVO18_001887"
     CDS             complement(1032..1406)
                     /gene="crcB"
                     /locus_tag="VVO18_001887"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000712114.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="HEU5586976.1"
                     /translation="MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNY
                     LGIFCLIYLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYLSLI
                     LYLLLSIGGGLLLAYYLGRKKW"
     gene            complement(1403..1669)
                     /locus_tag="VVO18_001888"
     CDS             complement(1403..1669)
                     /locus_tag="VVO18_001888"
                     /EC_number="5.4.99.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398165.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chorismate mutase"
                     /protein_id="HEU5586977.1"
                     /translation="MDLDIIRQEIDQIDDQIVKLLEERMHLVEGVVAYKKASGKPILD
                     TKREEVIFEKVRSRVEDKRYQETIVATFSDILKRSRDYQDQNIK"
     gene            complement(1785..2228)
                     /locus_tag="VVO18_001889"
     CDS             complement(1785..2228)
                     /locus_tag="VVO18_001889"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016465724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="flavodoxin"
                     /protein_id="HEU5586978.1"
                     /translation="MALAKIVFASMTGNTEEIADIVADKLRDLGLDVDVDECTTVDAS
                     DFLEADIAIVATYTYGDGELPDEMMDFYEDLADLNLNGKIYGVVGSGDTFYDEFCKAV
                     DDFDRVFVSTGAEKGSECVKVDLSAEEEDIERLEQFAEELAAKVG"
     gene            2332..3267
                     /locus_tag="VVO18_001890"
     CDS             2332..3267
                     /locus_tag="VVO18_001890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional oligoribonuclease/PAP phosphatase
                     NrnA"
                     /protein_id="HEU5586979.1"
                     /translation="MEICQQILEKIKEYDTIIIHRHMKPDPDALGSQVGLKALLEHHF
                     PEKTIKAVGFDEPTLTWMAEMDLVEDRAYQGALVIVCDTANTARIDDKRYSQGDFLIK
                     IDHHPNDDVYGDLSWVDTSSSSASEMITLFAQTTQLALADRDAELLFAGIVGDTGRFL
                     YPSTTARTLRLAAYLREHNFDFAALTRKMDTMSYKIAKLQGYIYDHLEVDENGAARVI
                     LSQEVLKQYNVTDAETAAIVGAPGRIDRVSLWGIFVEQADGHYRVRLRSKIHPINEIA
                     KEHDGGGHPLASGANSYSLEENEIIYQKLKNLLKN"
     gene            3321..3605
                     /locus_tag="VVO18_001891"
     CDS             3321..3605
                     /locus_tag="VVO18_001891"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008808933.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="HEU5586980.1"
                     /translation="MARKETMAERKYCKMKKDIHPEYRPVVFMDTTTGYQFLSGSTKR
                     SNETVEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK"
     gene            complement(3662..3880)
                     /locus_tag="VVO18_001892"
     CDS             complement(3662..3880)
                     /locus_tag="VVO18_001892"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000028153.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586981.1"
                     /translation="MSISPRFETLEQAIASKDLEKVREAFKKMNSTWTINESVVRDNS
                     TAHYGRVETAISFLPSSMETEPTDESGT"
     gene            complement(3877..4780)
                     /locus_tag="VVO18_001893"
                     /pseudo
     CDS             complement(3877..4780)
                     /locus_tag="VVO18_001893"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=3
                     /transl_table=11
                     /product="IS630 family transposase"
BASE COUNT         1466 a         1054 c          867 g         1393 t
ORIGIN      
        1 ttatctgatg attgcccaaa tttttcaata ataaaacgca taatattatg gagacacaca
       61 aaatcaccta tattatgcgt tcttttaata tcaaagactt tttgacaaac ttctttgatg
      121 tctaattact gccccctgca ggaatcgaac ctgcaactac tccttaggag ggagttgtta
      181 tatccattga actaagggag ctagataaaa actctgctga aaagcagagt tttttagtcg
      241 aattaacgac gaatttcttt gatacgagct gctttacctt gaagagcacg caagtagtac
      301 aatttcgcac gacgtacttt accgtaacga acaacttcga ttttttcaac acgtggagtg
      361 tggattggga agatacgctc aacacctaca ccgttagaga ttttacgaac tgtgtagttt
      421 tctgagattc cagcaccttt acgtgcgata acaacacctt caaaaatctg gatacgttca
      481 cggttacctt cgacaacttt cgcatgtaca cgaacagtgt caccaggacg gaatgatggg
      541 atatctgtac gaagttgacc ttcagtcaag ctttggatta atggattcat tttattctcc
      601 tatctttgtc aatcttgagg aatcttcctc agcggataaa ctgtattttt gtgcgtccat
      661 tacacacaag atatagttta ccaaatttct aaaaaaaagt aaagaaattt atagcaaaat
      721 tcctaaaaaa atcgcaacca aaccacctat gtaagtcaaa gtcaggtaag aataaaagac
      781 cttcttatca cttagcagtc tttgaagttc gtcattcaag gtcgaaaaag ttgttaaacc
      841 gccacaaaat cctgttgcta gaatagcata tacttcctta gactctacat gattgtagaa
      901 tactccaatt aaaaaacaac ctaaaagatt agctatgagc gttccgagtg gcaatttaga
      961 agcttgatta tagcgagaaa agaaataccg tacgagtgct cccaagccac aggcgattgc
     1021 aagatagacg attaccattt cttcctcccc aaatagtaag ctaaaagcag gcctccaccg
     1081 atactcaaaa gcaaatacag tatcaaacta agataacgcc ctgtatcaag cagcttcaca
     1141 gtatcaagca ttaggctgga aaaagttgtt aaacctccgc aaaaacccgt ccccagtgct
     1201 aaaatcaagc ccttactagt ccccttatag accagatagc ccttgacaag ataaatcaag
     1261 cagaaaattc ccagatagtt gacaaagaga gtgccccaag gaaagtctgg actggctggt
     1321 aaccaggtgg aaactagata tcggacaagt ccgcccaaca tagcagctag aaaaattcct
     1381 agcggataaa attgttcttt tttcatttga tattttgatc ctgataatca cgcgaacgtt
     1441 tgagtatgtc cgaaaaagtc gctacaatag tctcctgata gcgcttgtcc tctacacgac
     1501 tcctaacctt ttcaaaaata acttcttctc tcttagtatc taaaatcggt ttacctgaag
     1561 ctttcttata agcaaccacc ccctcaacta aatgcattcg ttcttctaac agtttgacaa
     1621 tttgatcgtc gatttgatcg atttcttgac gaataatatc taaatccata cagtctcctc
     1681 ctttatttga attattgtat caaaaagcca tcaattaggc tagtaaaatc ccaactctcg
     1741 ataagaaaaa tgcactgatt gattacatca gcgcactttt atgtttatcc tactttagca
     1801 gccaattctt ctgcgaattg ttccaagcgt tcaatatctt cttcctcggc agaaagatca
     1861 actttaacac actctgaacc tttttctgct cctgttgaca caaagacacg gtcaaagtca
     1921 tcaacagcct tacagaattc atcgtagaag gtatctcctg agccgaccac tccgtagatt
     1981 ttgccattca agttgagatc tgctaggtct tcgtagaagt ccatcatctc atctggcaat
     2041 tcaccatcac cataagtata ggtcgcaacg atagcgatgt ctgcttccaa gaagtctgaa
     2101 gcgtcaacag ttgtacattc atcaacatca acatccaagc ccaagtcacg taatttgtct
     2161 gctacaatat ctgcaatttc ttcggtatta ccggtcatac tggcaaatac aatttttgct
     2221 aatgccatat cgtcctcctc aatttatctt tctccattat atcacatctt tttcatttta
     2281 aaaataaaaa ttcttgtgct acaatgaaat gagaaagaat tgaggttatt tatggagatt
     2341 tgccaacaaa ttttagaaaa aattaaagaa tacgacacca ttatcattca tcgtcatatg
     2401 aaaccagacc ctgatgcctt gggaagtcag gtgggattga aagccttgct ggaacatcat
     2461 ttcccagaaa aaaccatcaa agccgtcggt tttgatgaac caactcttac ttggatggct
     2521 gagatggatc ttgttgaaga tagagcctac caaggcgcac ttgtcatcgt ctgtgataca
     2581 gctaatactg ctcgtatcga tgataagcgc tatagtcaag gtgattttct cattaagatt
     2641 gaccaccatc caaatgatga tgtatacggt gacctgtctt gggtcgatac tagttcaagt
     2701 agcgctagcg agatgattac cctatttgcc caaacaaccc aactagcctt ggcagatcgc
     2761 gatgctgagt tgctctttgc aggaattgtc ggtgatacag gtcgcttcct ctacccttct
     2821 accactgcac ggactcttcg cctggctgct tatttgagag aacataactt tgactttgcg
     2881 gctctcactc gcaaaatgga cactatgagc tacaaaattg ctaaactgca aggctacatc
     2941 tacgaccatc tggaagtgga tgaaaatggt gctgctcgcg ttatcctgag tcaagaagtc
     3001 ttgaaacaat acaatgtaac cgatgctgaa actgcagcca ttgtcggtgc acctggacgc
     3061 attgacagag tgagtctctg gggaattttt gtcgaacagg ctgatggcca ctaccgagtt
     3121 cgcttacgca gtaaaatcca tcctatcaat gaaatcgcca aggagcatga tggtggaggc
     3181 caccctctag caagtggtgc taattcctat agcctagaag aaaacgaaat catctaccaa
     3241 aagttaaaaa acttgcttaa aaactgataa aatacttgcc aaacttttca gaatctgata
     3301 gactagtacg gtaacaatct atggctcgca aagagaccat ggcagaaagg aaatattgca
     3361 aaatgaaaaa agatatccat ccagaatatc gcccagttgt cttcatggac acaactactg
     3421 gttaccaatt ccttagcggt tcaacaaaac gctctaacga aacagttgag ttcgaaggcg
     3481 aaacttaccc attgatccgt gtggaaattt catcagactc acacccattc tacactggac
     3541 gtcaaaagtt cactcaagca gatggacgcg tggatcgttt caacaaaaaa tacggtctca
     3601 aataatgata agagaacagt ttcggctgtt cttttttgtt tcttgaaatc aactgctgtt
     3661 ttcatgttcc agactcatct gtaggttcgg tttccatgct actaggcagg aaggaaatag
     3721 ctgtttcaac acgtccataa tgagctgtac tattgtcacg aaccacactt tcattgatgg
     3781 tccaagtgga attcattttc ttaaaagctt ctcggacttt ttccaaatct ttggaggcaa
     3841 tggcctgctc taaggtttca aaacgaggac ttatactcat ctgctttcac aaagcattct
     3901 agtccatctc cgattaacga tggactttat cacctccttc tccagtcctt gtatgacatc
     3961 ttgaagttga ttcatgacat cttccaaagt ttgaaaggct ttattcttaa atccacgttt
     4021 acgaatctct ttccacactt gttcaatggg gtttatctct ggtgtgtatg gaggaataaa
     4081 tgcaaagcca atattagtcg gaatctttaa ggtacttgat ttatgccata tagcattgtc
     4141 cataacgagt aaaagataat catctggata agcttgtgaa agctcttcta aaaaggcgtt
     4201 catccactca gtattacatc caccagctct taagaaaaat gattcgcctg tatgggcatc
     4261 aacagctcca taacaatagt gaaattctcg tatatagtga ctatggacat gtggacctac
     4321 tcctattgga gcccaacaag atcccagttt actgattcta ccgaaaccag cctcatcttg
     4381 gtacatcaag cgaaccttat gaaaaggtct actggtttta aaacgctttc ttttcttctt
     4441 gaattgagat tttattttta gacgcgacaa tggtttgagc gtctgctttc ctaggatgtt
     4501 ctggacgtgg cataatattt cgccaaccat ggcgcttcaa cagttgatag aaggcatcac
     4561 gtgtgtagga acgatataag cctgaaataa ggtattgtaa caaattctcc tgcctctgta
     4621 gccttcaaat ggcgggcaag aaagactttc tcttcctcaa ctgtcatata tgcatggtta
     4681 cgaccaccac gtgtttcttg aaggagagag tcgagtccga actcctcata tttttttaca
     4741 tttcgccaaa tcgttgtttg attacagtct atagtgtatt
//
LOCUS       DAVHIZ010000081         4724 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.083, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000081 DAVHIZ010000000
VERSION     DAVHIZ010000081.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.083"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            108..956
                     /locus_tag="VVO18_001894"
     CDS             108..956
                     /locus_tag="VVO18_001894"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000592058.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YitT family protein"
                     /protein_id="HEU5586982.1"
                     /translation="MIKKIYPIFTILLGAAIYAFGLTYFVVPHHLFEGGATGITLITF
                     YLFKIPVSLMNLLINIPLFILAWKIFGAKSLYSSLLGTLALSAWLAFFEHIPLHIDLQ
                     GDLLITALIAGILLGIGLGIIFNAGGTTGGTDILARILNKYTHISIGKLLFILDFCIL
                     MLILLIFKDLRLVSYTLLFDFIVSRVIDLIGEGGYAGKGFMIITKRPDQLAKAINDDL
                     GRGVTFISGQGYYSKENLKIIYCIVGRNEIVKTKEMIHRIDPQAFITITEAHEILGEG
                     FTFEKE"
     gene            complement(1049..1966)
                     /locus_tag="VVO18_001895"
     CDS             complement(1049..1966)
                     /locus_tag="VVO18_001895"
                     /EC_number="2.7.1.26"
                     /EC_number="2.7.7.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000587449.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional riboflavin kinase/FAD synthetase"
                     /protein_id="HEU5586983.1"
                     /translation="MIITIPIKNQKDIGTPSDSVVVLGYFDGIHKGHQELFRVANKAA
                     RKDLLPIVVMTFNESPKIALEPYHPDLFLHILNPAERERKLKREGVEELYLLDFSSQF
                     ASLTAQEFFATYIKAMNAKIIVAGFDYTFGSDKKTAEDLKDYFDGEVIIVPPVEDEKG
                     KISSTRIRQAILDGNVKEAGKLLGAPLPSRGMVVHGNARGRTIGYPTANLVLLDRTYM
                     PADGVYVVDVEIQRQKYRAMASVGKNVTFDGEEARFEVNIFDFNQDIYGETVMVYWLD
                     RIRDMTKFDSVDQLVDQLKADEEVTRNWS"
     gene            2404..2609
                     /locus_tag="VVO18_001896"
                     /pseudo
     CDS             2404..2609
                     /locus_tag="VVO18_001896"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844775.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
     gene            complement(2814..3107)
                     /gene="rpmA"
                     /locus_tag="VVO18_001897"
     CDS             complement(2814..3107)
                     /gene="rpmA"
                     /locus_tag="VVO18_001897"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018376869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L27"
                     /protein_id="HEU5586984.1"
                     /translation="MLKMTLNNLQLFAHKKGGGSTSNGRDSQAKRLGAKAADGQTVTG
                     GSILYRQRGTHIYPGVNVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK"
     gene            complement(3124..3468)
                     /locus_tag="VVO18_001898"
     CDS             complement(3124..3468)
                     /locus_tag="VVO18_001898"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000613691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribosomal-processing cysteine protease Prp"
                     /protein_id="HEU5586985.1"
                     /translation="MIQAVFERAEDGELRSAEITGHAESGEYGLDVVCASVSTLAINF
                     INSIEKFAGYEPILELNEDEGGYLMVEIPKDLPSHQREMTQLFFESFFLGMANLSENY
                     SEFVQTRVITEN"
     gene            complement(3484..3798)
                     /gene="rplU"
                     /locus_tag="VVO18_001899"
     CDS             complement(3484..3798)
                     /gene="rplU"
                     /locus_tag="VVO18_001899"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="50S ribosomal protein L21"
                     /protein_id="HEU5586986.1"
                     /translation="MSTYAIIKTGGKQVKVEVGQAVYVEKLNVEAGQEVTFNEVVLVG
                     GENTVVGTPLVAGATVVGTVEKQGKQKKVVTYKYKPKKGSHRKQGHRQPYTKVVINAI
                     NA"
     misc_feature    complement(3834..3921)
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00559"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="ribosomal protein L21 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /db_xref="RFAM:RF00559"
     gene            complement(3986..4684)
                     /locus_tag="VVO18_001900"
     CDS             complement(3986..4684)
                     /locus_tag="VVO18_001900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004241810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1275 domain-containing protein"
                     /protein_id="HEU5586987.1"
                     /translation="MGGKMRLLPIRKISRQSKRLALFLTFCAGYVDAYTFIVRGNTLV
                     AGQTGNVVFLSVELIKNNVSDVRDKVLTLLAFMMGVFLLTIYKEKLRIVKKPILSLIP
                     LAILSIIIAFVPQTVDNIYLVPPLAFCMGLVTTAFGEVSGIAYNNAFMTGNIKRTMLA
                     FGDYFRTKHTPFLREGFIFVSLLSSFVLGVVFSAYLTIFYHEKTILGVPIMMSVFYLS
                     MLFASWQKKVKEKA"
BASE COUNT         1459 a          970 c          793 g         1502 t
ORIGIN      
        1 tttccttact tctaattata tcaaaaaaaa gattaaaaat cctaatggag tcaatcaaat
       61 tttccgtaaa atttgatata atcaacttat aagaaaagag gtgtcctatg attaaaaaaa
      121 tttaccccat ttttaccatt ttactaggtg ctgctattta tgcttttgga ctgacttatt
      181 ttgtagttcc ccatcatctc tttgaaggag gggcgacagg cattaccctc atcacctttt
      241 atctttttaa aatccctgtt tccctcatga acctgctgat taatattccc cttttcatcc
      301 tagcttggaa gatctttgga gccaaatccc tctattctag tttactagga accttagctt
      361 tgtccgcctg gttagctttt tttgagcata ttccccttca tattgatctt caaggtgatt
      421 tactaatcac agcccttata gcgggaatcc tattgggaat tggccttgga attattttta
      481 atgctggagg tacaactggc ggaactgata ttctagctcg tattctcaac aaatacactc
      541 atatatccat aggaaaactg ctctttatct tagatttttg tattctcatg ttgattctcc
      601 taatcttcaa ggatttgaga ttggtttcct acacgctttt gtttgatttt attgtttctc
      661 gtgttattga tttgattggt gaaggaggat atgccggcaa aggctttatg attatcacaa
      721 aacgtcctga ccaacttgct aaggcgatta atgatgacct cggaagaggt gttactttta
      781 tttctggtca aggctactat agtaaagaaa atttgaaaat catctactgt attgtcggaa
      841 gaaatgaaat tgtgaaaacg aaggaaatga ttcatcgaat cgatcctcaa gcctttataa
      901 ctattacaga agcccatgaa atcctaggag aaggcttcac ctttgaaaaa gaataaaaag
      961 aggtaatgtc gtgacctcaa aagttagact aaatcatcta tcttttgggt tacagacaac
     1021 ctctttttta ttttatttac tcaagctctt aagaccaatt ccgagttact tcttcatcag
     1081 cctttaactg atccactaat tggtcaactg agtcaaattt ggtcatatca cgaatgcgat
     1141 caagccaata aaccatgacg gtttccccat aaatatcttg attaaaatca aaaatattga
     1201 cttcaaaacg tgcttcttct ccatcaaagg tcacattttt cccgacacta gccatagcac
     1261 gatacttctg tctttgaatc tcaacatcaa cgacataaac gccatctgct ggcatataag
     1321 tacggtctaa aagcactaaa ttcgctgtcg gataaccaat tgtacgacca cgagcattac
     1381 catgaaccac catacctctt gatggaagcg gtgcccccaa aagttttcct gcttctttca
     1441 catttccatc taaaatagct tgacggatac gagttgaact aatctttcct ttctcatctt
     1501 ctacaggtgg aacaatgata acttctccat caaagtaatc ctttaaatct tctgctgttt
     1561 ttttgtcaga accaaatgta taatcaaaac ctgcaacaat aattttggca ttcatagcct
     1621 tgatataagt tgcaaagaat tcttgtgcag tgagactagc gaattgacta ctaaaatcaa
     1681 ggagatataa ttcttctaca ccttcgcgct ttaattttct ttcacgttca gcagggttca
     1741 aaatatgcaa aaacaaatct ggatgataag gctctaaagc gatctttgga gattcattaa
     1801 aggtcataac gacgataggt aataaatcct ttctcgcagc cttgttggca acacgaaata
     1861 attcttgatg ccccttatgt atgccatcaa aatagccgag aacaacgact gaatcagatg
     1921 gtgtgccaat atctttttgg ttttttatag gaatagtaat aatcataaaa taattatatc
     1981 atagcgatag ctatttctgg aacagaaaat ctgaaatgtt gtttttttca catgaagtgt
     2041 acctgttttc aaaaagcact ttattctatc gttgcttaac tatgaacttt gcaatattct
     2101 tctcaaaaac ttgtaggaca tcttcaaaat tttgcaagga gtgattagac ttgttcggta
     2161 accataaagt gtcatactat gcttatgtat gaaaaagcaa tgcaactaac tcctgagaac
     2221 tttaaattac taattggtgc cgaaaaggta gaatttagaa tcgaggtaca cctatggctg
     2281 taaaatttac aaaatgagac aacttgggca agatgtttga agaatttcct aaactccctg
     2341 atttgaagca agtcactttc cctgatgaca aagaaaaaag ccaaaacagc aaagaaaaac
     2401 tagatgactg ctttccaaca actcccatct agtgtgcttc agactgggct atttttctct
     2461 ccatctgtta gcttggattc tcagacagtt tcagctaaag aatatctttt cccttatcag
     2521 aaggaacggc tcaaaccatt cagacaagtg aagggacgac aagccaatat ttgaaaccag
     2581 atagcagttc ttatagtcaa ttgaaataaa atctgaagaa atcgagtagg aaactcatat
     2641 caatttttaa cagtgttcta ttccagattc aatccactat acatattaaa aagtatgggt
     2701 accaaaacaa aaaaacaggc tctccgaaaa ctcggaaagc cttattttaa gctgtttcta
     2761 gcttcctcac ctttacattt caaggttcgg gataaaaggt tcaatggacc tttttattta
     2821 gcgattgggt aaacagaaac ttgtttttta tcgcgtcctt tacgttcaaa gcgtactacg
     2881 ccttcaactt tagcgaacaa agtatcgtct ccaccacgac caacgtttac acctggatag
     2941 atgtgtgtac cacgttgacg gtaaaggatt gatccacctg ttacagtttg tccgtcagct
     3001 gctttagctc caagacgttt tgcttgtgaa tcacgtccgt ttgatgtaga acctccacct
     3061 tttttgtggg cgaaaagttg caagttgtta agagtcattt ttaacataat gttttcctcc
     3121 gtgttagttt tctgtgataa ctctggtttg gacgaactca gaatagttct ccgataagtt
     3181 tgccatacct aagaaaaatg attcaaagaa taactgggtc atttctctct ggtgtgaagg
     3241 aagatctttt ggtatttcaa ccatcagata gccaccttca tcttcgttta attctaggat
     3301 tggttcatag cctgcaaatt tctcaataga attgataaag ttaatggcaa gcgtagaaac
     3361 cgatgcacac acgacatcta agccgtattc gccactctcg gcgtgtccag taatttccgc
     3421 actcctcagc tcgccatctt cggctctctc aaagactgcc tgtatcatgt gttctcctta
     3481 aaattaagcg ttgattgcgt tgatgacaac ttttgtatat ggttgacggt gaccttgttt
     3541 acggtggcta ccttttttag gtttgtactt gtaagtaacc actttctttt gttttccttg
     3601 tttttcaaca gttccaacta cagtagctcc agcaacaagt ggagttccga caacagtatt
     3661 ttcaccacca acaagaacaa cttcgttaaa agtaacttct tgaccagctt caacgttcaa
     3721 tttttcaacg taaactgctt gaccaacttc aactttaact tgttttccgc cagttttgat
     3781 aattgcgtat gtgctcatta tgcacctcct atgattttta tgggtttccc cgattttttg
     3841 tgaagactcg cctagcatcg tgggacgaac cacttaaact tgaataatca agcaacgatg
     3901 ttcgtgcggt tgcacaggat cgtgcatagt caactcttca agtatagcat atctcctatt
     3961 ttcttacaag taataacacc taaaatcaag ctttttcttt tacttttttc tgccaagagg
     4021 caaaaagcat gctgaggtaa aaaacgctca tcataatagg aacaccaaga atggtctttt
     4081 catgatagaa aatcgtcaaa taggctgaaa agacaacgcc aaggacaaaa ctactaagca
     4141 ggctaacaaa tatgaatcct tcacgcaaaa aaggagtgtg cttggttcgg aaataatctc
     4201 caaaagccag catggtccgt ttgatattcc ctgtcataaa agcgttatta taggcaatac
     4261 ccgacacttc tccaaaagca gttgtcacca gtcccataca gaaggccaag ggcggcacta
     4321 gatagatatt atccacagtt tgcggcacaa aagcaataat gattgataag attgccaagg
     4381 gaatcaagga cagaataggt tttttcacaa ttctcaattt ttccttataa atcgttaata
     4441 aaaagactcc catcataaac gctagcaagg tgagaacctt gtccctaaca tccgaaacat
     4501 tatttttaat taattctact gaaagaaaga caacatttcc agtttgtcca gctacaaggg
     4561 tattcccgcg aacaataaaa gtgtaagcat ccacatatcc agcacaaaac gtcaaaaaaa
     4621 gtgctaacct tttagactga cgtgatattt ttcttatagg taataacctc attttccctc
     4681 ccattgtatt ttctcttaga aatattgtac catttctttc taaa
//
LOCUS       DAVHIZ010000082         4626 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.084, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000082 DAVHIZ010000000
VERSION     DAVHIZ010000082.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4626)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4626)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4626
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.084"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..245
                     /locus_tag="VVO18_001901"
     CDS             <1..245
                     /locus_tag="VVO18_001901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="glycerophosphoryl diester phosphodiesterase"
                     /protein_id="HEU5586988.1"
                     /translation="PIISKKIIDDLHEKGLLIWVNALTLSDSIILSAKIDDDTAIAHD
                     GESWGKLVSIGFDIIQTDWPLLLYQYLVEKNKKIKK"
     gene            272..1333
                     /locus_tag="VVO18_001902"
     CDS             272..1333
                     /locus_tag="VVO18_001902"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000475757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extracellular solute-binding protein"
                     /protein_id="HEU5586989.1"
                     /translation="MFKNFKKIAFTSSLILLAACSNNASNTNQSTDEGSVDKSQEIVI
                     YTNSASNGRADWLQTKASEQGYNLRLVDISGGELADRLIAEKNNAVADMVIGLNKLEF
                     NRIKAEKLLVKYSPKWADEVDSSLGDSEGYYSPIVNQPLVLIGNKDAKMPSDWTDFTD
                     SSYKGKYGISKLSTGTSKNIFASIVSRYKDEKGELGISDEGWKVAKAYLKNAHVYAEG
                     EDYISSIMDNNNDLKYSMMWGSGVLQNQKEREYKFQVMSPKVGVPYVTEQVGILNTSK
                     KQALLKEFVDWFGSSELQKEWSDKFGSIPANKKALEQAKDELKQFANSVKPQELDWEF
                     IGKNIDSWIEKAQLEFVEQ"
     gene            1350..2354
                     /locus_tag="VVO18_001903"
     CDS             1350..2354
                     /locus_tag="VVO18_001903"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847714.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5586990.1"
                     /translation="MITFKDIQIKYNDFIAIDNLNLTINEGEFFTFLGPSGCGKSTTL
                     RALVGFLEPSQGQILVDNQDITNLDPEKREIGIVFQSYALFPTMTVFDNIAFGLKVKK
                     VSPEIIKAKVHEIAKKINISDEQLNRNISELSGGQQQRVALARALVLEPKILCLDEPL
                     SNLDAKLRVSLRKELKRLQKELGITTLYVTHDQEEALTLSDRIAVFNNGFIEQVGTPY
                     DIYNQSATQFVCDFIGSINKISQEVLKKLQGENKYFKETEGYIRLERVKLEKTSPQDL
                     SITGVISDIEFNGVLIKYKVDLSNSESIHIIEKNDGLSRHIIKEKVTMYINPRDIMQF
                     "
     gene            2366..4060
                     /locus_tag="VVO18_001904"
     CDS             2366..4060
                     /locus_tag="VVO18_001904"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001865847.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU5586991.1"
                     /translation="MRKSLNWKDCLIRLGVLWLIFALIIYPNIELLSGVFYKNGSFTL
                     EAFNKIIHSQRAMSSIFNSFILAISMVFTVNIVGTLIVLLTEYWDIRGSKILKLGYMS
                     SLVYGGIVLATGYKFVYGANGLVTKTLSSIIPGLAPNWFQGFGAVLFIMTFACTSNHI
                     MFLTNAVRSVDYHTIEAAKNMGASPLKVFFSVVFPTFKPTLFALTILTFLTGLSAVSA
                     PLIVGGKDFQTINPLIISFAKTTSSRDLAALLAIMLGLATILLLTLLNHVEKGGNYVS
                     VSKTKASIKKQIISSPLWNTLAHIVAYVLFAIYMLPIVLIILYSFTDSLTIKTGTLDL
                     SKFTLANYANLFTDAQSFRPYLVSVVYAILAAVIATIIAIVISRIVHKNKSKFDKFFE
                     YGALIPWILPGTLIALGLMFTYNIPHLILFNLVLVGTVIILLIAYTIQKLPFSYRMIR
                     AVFFSIDNDMEEAARSMGASSFYTMVRVIIPYILPVVLSVVVLNFNSLLSDYDLSVFL
                     YHPLFQPLGIVIKQSTDETATLNAQAMMFVYSVILMIMSSAALYLSSLFQGKRGKR"
     gene            4062..>4626
                     /locus_tag="VVO18_001905"
     CDS             4062..>4626
                     /locus_tag="VVO18_001905"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001054457.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MgtC/SapB family protein"
                     /protein_id="HEU5586992.1"
                     /translation="MNLSYELSIWEILLRCFLAILFGGIVGYERGVKNQAAGIRTYLL
                     VCLGTCVVMMTNQFITSRYGSGDPSRMGAQVISGLGFLGAGTIMVTNQKVKGLTTAAG
                     LWSSATIGLAIGIGFYEGAILAGVVLIAVLTLFTPLKDYLNSKTKIADYYLVFSSLEG
                     YNRLLIYLNTSGIKILEIQNGIGNLDEE"
BASE COUNT         1554 a          651 c          856 g         1565 t
ORIGIN      
        1 atccaatcat aagtaagaaa ataattgatg atttacatga aaaaggatta cttatttggg
       61 ttaatgcttt aaccttaagt gattcaatta ttctttcggc taagattgat gatgatacag
      121 ctattgctca tgatggcgaa tcttggggga aattggtttc aataggattt gatattattc
      181 aaacagattg gccattatta ctttatcaat atctagttga aaaaaataaa aaaataaaaa
      241 aataaaaaaa taaaaataaa ggagaactat catgttcaaa aactttaaaa agattgcatt
      301 cacttcttca ctaattttac ttgctgcttg ctcaaacaat gcttcaaata caaatcagtc
      361 tactgatgaa ggaagtgttg ataaatctca agaaattgta atctatacaa attcggcttc
      421 taatggacgt gcagattggt tacaaactaa agcatcagag caaggataca atcttcgttt
      481 ggtagatatt tcaggtggag aactagctga ccgtttgatt gcagaaaaga ataatgctgt
      541 ggctgatatg gtaattggat taaataaatt agaatttaat cgtattaaag ctgaaaaact
      601 tcttgtaaaa tactcaccaa aatgggctga tgaagtagat agctctttgg gagattctga
      661 agggtattat tcaccaattg taaatcaacc attagttttg attggtaata aagatgctaa
      721 aatgccatcc gactggacag attttactga ttcatcttat aaaggtaaat atggtatttc
      781 aaaattaagt acaggtacat ctaagaacat ctttgcaagt attgtttcga gatataaaga
      841 tgaaaaaggt gagttaggaa tatctgatga aggttggaaa gttgcaaaag cttaccttaa
      901 aaatgcacac gtttatgcag aaggtgaaga ctatatctct tcaattatgg ataataataa
      961 tgatctaaaa tatagtatga tgtggggatc tggtgttcta caaaatcaaa aagaacgtga
     1021 atataaattc caagtaatgt caccaaaagt tggtgttcct tatgtaactg aacaagttgg
     1081 gattttaaat acaagtaaga agcaagcatt attaaaagaa tttgtagatt ggtttggctc
     1141 ttcagaactt caaaaagaat ggtctgataa atttggttca attccagcta ataaaaaagc
     1201 tctagagcaa gcaaaagatg aactcaaaca gtttgctaat agtgttaaac cacaagaact
     1261 tgactgggag tttatcggga aaaacatcga ttcttggatt gaaaaagcac agcttgaatt
     1321 tgttgaacaa taatagttag gattaagtga tgattacatt taaggatatt caaattaagt
     1381 ataatgattt tattgccatc gataatctca atttaacaat caatgaggga gagtttttca
     1441 catttttagg accaagtggt tgtgggaaat caacaactct tcgtgcacta gttggatttt
     1501 tggagccttc acaggggcaa atactagttg ataatcaaga tattacgaat ttagatccgg
     1561 aaaaacgcga aattggtatt gtgtttcaaa gttatgcatt attcccaaca atgactgttt
     1621 ttgataatat tgcttttggt ctaaaagtta aaaaagtttc tcctgaaatt attaaagcta
     1681 aagttcatga aattgcgaaa aaaattaata tctcagacga gcaactaaac cgaaatattt
     1741 ctgaattatc agggggacaa caacagcgtg tagctttagc acgtgcatta gtattagaac
     1801 caaaaattct ttgtttggat gaaccgttat caaacctaga tgccaaacta cgagtttcgt
     1861 tgagaaaaga attgaaacga ttgcaaaaag aactaggaat cactactctt tatgtcacac
     1921 atgatcaaga agaagcatta acattatcag ataggattgc tgtgtttaat aatggattta
     1981 ttgagcaagt tggcacgccg tatgatattt ataatcaatc cgcaactcaa tttgtctgtg
     2041 attttattgg ctcaatcaat aaaattagcc aagaagttct taaaaaatta caaggcgaga
     2101 ataaatactt taaagaaact gaaggataca tacgcttaga gcgtgttaag ttagagaaaa
     2161 cttcacctca agatttatct ataacagggg taattagtga tattgagttt aatggtgtac
     2221 ttattaagta taaagtagac ttgtcgaata gtgaaagtat tcatattatc gaaaagaatg
     2281 atggactatc acgtcatata atcaaagaaa aagtcactat gtacattaat ccgcgtgata
     2341 taatgcaatt ttaaggagat tgtgcatgag aaagagtcta aactggaaag attgtctcat
     2401 aagattagga gttttatggc taatctttgc cctgattatt tatccaaata ttgaactttt
     2461 gtctggagtg ttttataaaa atggttcatt tactctagag gcattcaata agattataca
     2521 ctctcagaga gcgatgagta gtatatttaa tagctttatt ttggcgattt caatggtctt
     2581 tactgtaaat attgttggga cattgattgt tctactcaca gagtactggg atattagggg
     2641 ttcaaaaata cttaaattag gttatatgag ctctctagta tatggaggaa ttgtattagc
     2701 gacaggatat aaatttgttt atggcgctaa tggtcttgta actaaaacgc tctcaagtat
     2761 aattccaggt cttgccccta actggtttca aggatttggt gcagtattgt ttattatgac
     2821 atttgcttgt acctcaaatc acataatgtt tttaacaaat gcagttcgta gtgttgatta
     2881 tcatacaatt gaggcagcta aaaatatggg tgcaagtcct ttaaaagttt tctttagtgt
     2941 ggtttttcca acttttaaac ctacgttatt tgccttaacc atcttaactt ttttgacagg
     3001 tctttcagca gtttctgctc ctttgatagt aggggggaaa gattttcaaa ctattaaccc
     3061 attgattatc agtttcgcta aaactacaag ttcgagagat ttagcagctt tactagctat
     3121 catgttaggt ttagcaacta ttctattatt gacacttttg aatcatgtcg aaaaaggagg
     3181 taattatgta tctgtttcga aaaccaaggc tagtattaag aagcagataa tttcttctcc
     3241 attatggaat actcttgctc acattgttgc gtatgtattg tttgcaatct atatgttacc
     3301 aatagttttg ataattctat actcgtttac agactcgttg acgatcaaga cgggaacttt
     3361 agatctatct aaatttacgt tagcgaacta tgctaattta tttacagatg ctcaatcatt
     3421 tcgtccttac ctagtcagcg ttgtttatgc aattttagct gcggtaattg ctacaattat
     3481 agcaatagta atttcacgta ttgtacataa aaacaagagt aagttcgata aattctttga
     3541 gtatggtgca ctgataccat ggatattgcc aggtacattg attgcactag gattaatgtt
     3601 cacttataat atacctcatt taatactatt taatttagtt ttagtaggaa cagtaattat
     3661 tttacttatt gcatatacta ttcaaaaatt accattttct tatagaatga ttcgggctgt
     3721 atttttcagt atagataatg atatggaaga agctgcacgt agtatgggtg catctagttt
     3781 ctacactatg gtgcgagtta ttataccgta tattttacca gtcgtattat cagtagttgt
     3841 gttaaacttt aattctttat tatctgacta tgacttatct gtattcttgt accatccact
     3901 tttccaacca ttgggaatcg ttattaaaca gtctactgat gaaacagcaa ctttaaatgc
     3961 acaggcaatg atgtttgttt attctgtaat tttaatgatt atgtctagtg cagctcttta
     4021 tttatcaagc ctattccaag gtaaacgagg taagagataa tatgaatctt tcatacgaac
     4081 tgagtatttg ggaaatactt cttaggtgct ttttagcgat tcttttcggt ggcattgttg
     4141 gctatgagcg aggagtcaaa aaccaagcag cagggattag aacctactta ctagtttgtt
     4201 tgggaacttg tgttgtaatg atgacaaatc agttcatcac tagtcgttat ggtagcggtg
     4261 atcctagtcg aatgggagcc caagtaatta gtggcttggg tttcctaggg gcaggaacaa
     4321 tcatggtaac taatcaaaaa gttaaaggtt taacaacagc agctggatta tggtcttcag
     4381 caactattgg tttagctata ggcattggtt tttatgaagg tgctatttta gccggagttg
     4441 tactcatagc agttttaact ctatttactc ctcttaaaga ttatttaaac tcgaaaacta
     4501 aaattgctga ttactacttg gtttttagtt ctttagaagg ttataatcgt ttacttatat
     4561 atttaaatac atcgggtatt aagattttag aaattcaaaa tggtatagga aatcttgatg
     4621 aagaac
//
LOCUS       DAVHIZ010000083         4606 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.085, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000083 DAVHIZ010000000
VERSION     DAVHIZ010000083.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4606)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4606)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4606
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.085"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(143..1129)
                     /locus_tag="VVO18_001906"
     CDS             complement(143..1129)
                     /locus_tag="VVO18_001906"
                     /EC_number="1.1.1.27"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019768616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="L-lactate dehydrogenase"
                     /protein_id="HEU5586993.1"
                     /translation="MTSTKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLH
                     EKAVGDALDLSHALAFTSPKKIYAAQYSDCADADLVVITAGAPQKPGETRLDLVGKNL
                     AINKSIVTQVVESGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQ
                     ALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANIAGVNLEEFLKDTQNVQEAELIELF
                     EGVRDAAYTIINKKGATYYGIAVALARITKAILDDENAVLPLSVFQEGQYGVENVFIG
                     QPAVVGAHGIVRPVNIPLNDAETQKMQASAKELQAIIDEAWKNPEFQEASKN"
     gene            1323..3791
                     /gene="gyrA"
                     /locus_tag="VVO18_001907"
     CDS             1323..3791
                     /gene="gyrA"
                     /locus_tag="VVO18_001907"
                     /EC_number="5.6.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001152996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA gyrase subunit A"
                     /protein_id="HEU5586994.1"
                     /translation="MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHR
                     RILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVD
                     GHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
                     FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTG
                     ALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVR
                     LVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAI
                     QNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIR
                     IIRASETDAEAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIAD
                     LADILAKPERVSQIIKDELDEVKRKFSDKRRTELMIGQVLSLEDEDLIEESDVLITLS
                     NRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRL
                     KGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVESDRSDDAYLFFTTRHGIVKRTS
                     VKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRI
                     ATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAK
                     ITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQI
                     VTFTTVAVAEKEEVGTENETEGEA"
     gene            3791..4534
                     /gene="srtA"
                     /locus_tag="VVO18_001908"
     CDS             3791..4534
                     /gene="srtA"
                     /locus_tag="VVO18_001908"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000078846.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sortase SrtA"
                     /protein_id="HEU5586995.1"
                     /translation="MSQKNNKKKNKRKNLLTNILAGFLILLSLALIFNTQIRNIFIVW
                     NTNKYQVSQVSKEKLEENQDTEGNFDFDSVKAISSEAVLTSQWDAQKLPVIGGIAIPE
                     LEMNLPIFKGLDNVNLFYGAGTMKREQVMGEGNYSLASHHIFGVDNANKMLFSPLDNA
                     KNGMKIYLTDKNKVYTYEIREVKRVTPDRVDEVDDRDGVNEITLVTCEDLAATERIIV
                     KGDLKETKDYSQTSNEILTAFNQPYKQFY"
BASE COUNT         1417 a          806 c         1028 g         1355 t
ORIGIN      
        1 taatggattg aaataagata tgaacaaatc gattaggaat ttaaagcatt ttataacaac
       61 gttttagagt aacggggtac tatttcatat aatacaggaa aaaacaactc cctgatgatt
      121 caaggagttg tctatagtta aattagtttt tagaagcttc ttggaattct ggatttttcc
      181 atgcttcgtc aataatagct tgcaattctt tagcagatgc ttgcattttt tgagtttctg
      241 catcgttcaa tggaatgttt actggacgaa cgataccatg tgcaccaaca acagctggtt
      301 gaccgataaa gacattctca actccgtatt gaccttcttg gaatactgaa agtggaagta
      361 ctgcgttttc atcgtcaagg attgctttag tgatacgagc aagggctact gcgataccgt
      421 agtatgttgc accttttttg ttgatgattg tgtaggctgc atcacgaaca ccttcgaaca
      481 attcaatcaa ttcagcttct tgaacatttt gagtgtcttt aagaaattct tcaaggttta
      541 caccagcgat gttagcgtgt gaccaaacag cgaactcaga gtcaccgtgt tcacccatga
      601 tgtaggcgtg cactgaacga gcatccacat ccaatttttc agcaagtgct tgacggaaac
      661 gagctgagtc aagtgaagta cctgaaccga taacgcgttc tttagggaaa ccagagaatt
      721 tccaagttga gtaagtcaaa acgtcaactg ggttagcagc aacaaggaag atacctttga
      781 aaccagattc aacaacttga gttacgattg atttgttgat agcaaggttt ttacctacaa
      841 ggtcaagacg agtttcacct ggtttttgag gtgcacctgc agtgatcaca acaaggtcag
      901 cgtctgcaca gtcagagtat tgagctgcat agattttttt aggtgaagtg aaggcaaggg
      961 cgtgactaag gtcaagcgca tcaccaacag ctttttcatg caattgtgga atttcgataa
     1021 ttccaagctc ttgtgcaatt ccttggttaa caagtgcaaa agcgtaagat gaacctacag
     1081 caccatcacc gacaaggata acttttttgt gttgtttagt tgaagtcatt gttttaaaca
     1141 tctccttaat tttattaggg gattttccct agacaacttc attctatcac ttttaaaaaa
     1201 ctttgtcacg aatatgcctt atagttctcg atgtaaacgt tttagtggtt tagaggctga
     1261 aatagatggg aatttatggt ataatgttgt tacttactaa ttgtgaaatg aggcatttat
     1321 taatgcagga taaaaattta gtgaatgtca atctgacaaa ggagatgaag gcaagtttta
     1381 tcgactacgc catgagtgtt atcgtagcgc gagctcttcc tgatgttcga gatggcttaa
     1441 aacctgttca ccgtcgcatt ctctacggaa tgaatgaatt gggtgtgacc ccagacaaac
     1501 cccataaaaa atctgctcgt attacagggg atgtcatggg taaatatcac ccacacgggg
     1561 attcctctat ttatgaagcc atggtccgta tggctcaatg gtggagctac cgttacatgc
     1621 ttgtagatgg tcatgggaat tttggttcca tggatggaga tagtgctgcc gctcaacgtt
     1681 ataccgaggc acgtatgagc aagattgctc tggaaatgct tcgtgatatc aacaaaaata
     1741 cagttgattt cgttgataac tatgatgcca atgaacggga acccttggtc ttgccagcgc
     1801 gttttccaaa ccttttggtt aatggagcaa ctggtatcgc ggttgggatg gcaaccaata
     1861 ttccacctca taatctgggt gaaaccattg atgcagtgaa gttggtcatg gataatcctg
     1921 aagtgactac caaggacttg atggaagtct tgcctggacc agattttcca actggtgctc
     1981 ttgtcatggg gaaatcaggt atccataagg cttatgaaac aggtaaaggt tcgattgtcc
     2041 tacgttctcg tacagagatt gaaacgacta agactggtcg tgagcgtatc gttgtaacag
     2101 aatttcctta catggtcaat aaaaccaagg tgcatgagca tattgttcgc ttggttcagg
     2161 aaaaacgcat tgagggtatc acagcagtac gtgatgagtc aaaccgtgaa ggtgttcgat
     2221 ttgttattga agtcaagcgc gacgcctcag ccaatgttat tctcaataac ctcttcaaaa
     2281 tgacccaaat gcaaaccaat tttggtttca atatgctcgc tatccaaaat ggtataccga
     2341 aaattttgtc tcttcgtcag attttggatg cttatatcga gcaccaaaaa gaagtggttg
     2401 ttcgtcgtac acgttttgat aaggaaaaag cggaagcgcg cgctcatatc ttagaaggtc
     2461 tcttgattgc gctagaccat atcgacgaag tgattcgtat catccgtgct agtgaaacgg
     2521 atgcggaagc tcaagctgag ttgatgagca agtttaagct ttctgaacgt caaagtcaag
     2581 ctatccttga tatgcgtctt cgtcgtttga caggtttgga acgcgataag attcaatctg
     2641 agtatgatga cctcttggct ctgattgcgg atttagcaga tattcttgct aagcctgaac
     2701 gtgtttctca aattatcaaa gacgaattgg atgaagttaa acgtaaattt tctgataagc
     2761 gccgtacaga gttgatgatt ggacaggtct tgagtctcga ggatgaggac ttgattgaag
     2821 aatcggatgt cttgattacc ctttctaaca gaggctacat taagcgtttg gatcaggacg
     2881 agttcactgc tcaaaaacgt gggggtcgtg gtgtccaagg aacgggagtg aaagatgatg
     2941 actttgttcg tgagttagtg tcaactagca cccatgatca tctgctcttc ttcacaaaca
     3001 agggacgtgt ctatcgtctt aaaggttatg aaattcctga gtatggtcgg actgccaaag
     3061 ggctaccagt agtcaatctc ttgaaattgg atgaagacga aagtattcag acggttatca
     3121 atgttgagtc tgatcgcagt gatgatgctt atctcttctt tacaacccgt cacggtattg
     3181 tgaagagaac cagtgttaag gagtttgcca atattcgtca aaatggtctc aaagcgctga
     3241 atttaaagga tgaagatgag ttaatcaatg tcttgttggc agaaggagat atggatatta
     3301 tcattggtac caagtttggt tatgcagttc gctttaatca atcagccgtt cgtggtatga
     3361 gtcgtatcgc cactggtgtg aaaggtgtta accttcgtga aggagacaca gttgttggtg
     3421 ccagcttgat tactgatcaa gatgaggttc ttattatcac agaaaaagga tatggtaagc
     3481 gtacagtcgc tactgaatac ccaacaaaag gtcgtggtgg taagggaatg cagacagcta
     3541 aaattaccga aaaaaatggc ttgctggccg gtcttatgac tgttcaaggg gatgaggatt
     3601 tgatgattat cactgataca ggtgtcatga ttcgaaccaa tcttgccaat atttcacaaa
     3661 caggacgtgc aactatggga gttaaagtaa tgcgcctgga tcaagatgct cagatagtga
     3721 ctttcacaac ggttgcggtg gcagaaaaag aagaagttgg gacagaaaac gaaacagaag
     3781 gtgaagcata atgtctcaaa aaaataataa aaagaaaaac aagcgaaaaa atctgctgac
     3841 aaatatccta gcaggatttc tgatattact gtcactggct ttgattttta atactcaaat
     3901 tcgaaatatt ttcatagtct ggaataccaa taagtatcaa gttagccagg tatcaaaaga
     3961 aaaattagaa gaaaatcagg atacagaagg caattttgac tttgattctg tcaaagctat
     4021 ctcttcggaa gctgttctaa cttctcaatg ggatgctcaa aaattaccag ttattggggg
     4081 aattgcaatt cctgaattgg aaatgaattt gccgattttt aaaggacttg ataatgttaa
     4141 tctcttctac ggagctggta caatgaaacg cgagcaagta atgggagaag gaaattatag
     4201 tctagctagt caccatatct ttggtgttga taatgctaat aaaatgttat tttctccttt
     4261 agataatgct aaaaatggca tgaagattta tctaaccgat aaaaataaag tttatactta
     4321 tgaaatacgt gaagtcaaac gtgtgacacc ggatcgtgtt gatgaagttg atgatagaga
     4381 tggggtcaat gaaatcacat tagtaacctg tgaagacctt gctgctacag aacgtattat
     4441 tgtcaaaggt gatttgaaag aaacaaaaga ttattcacaa acatctaatg aaatcctaac
     4501 agctttcaat caaccatata aacaatttta ttaatacaaa tcagtgaaat ccatgatttc
     4561 actgattttt taagattttc ataaaaatat agtaaaatga aataag
//
LOCUS       DAVHIZ010000084         4586 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.086, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000084 DAVHIZ010000000
VERSION     DAVHIZ010000084.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4586)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4586)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4586
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.086"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(358..909)
                     /locus_tag="VVO18_001909"
     CDS             complement(358..909)
                     /locus_tag="VVO18_001909"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000835652.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5586996.1"
                     /translation="MKSIGTQILQTERLILRRFVESDAEAMFQNWASSAENLTYVTWD
                     PHPDVEITRNSIRNWVASYTNLNYYKWAICLKENPEQVIGDISIVKIDEADLSCEIGY
                     VLGKAYWGHGMMTEALKAVLDFCFTQAGFQKVRARYASLNPASGRVMEKAGMSYLQTI
                     VNGVERKGYLADLIYYGISREEC"
     gene            complement(1259..2083)
                     /gene="nadE"
                     /locus_tag="VVO18_001910"
     CDS             complement(1259..2083)
                     /gene="nadE"
                     /locus_tag="VVO18_001910"
                     /EC_number="6.3.1.5"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058066.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ammonia-dependent NAD(+) synthetase"
                     /protein_id="HEU5586997.1"
                     /translation="MSLQETIIQELGVKPVIDAQEEIRRSIDFLKRYLKKHPFLKTFV
                     LGISGGQDSTLAGRLAQLAMEELRAETGDDSYKFIAVRLPYGVQADEADAQKALAFIQ
                     PDVSLVVNIKESADAMTAAVEATGSPVSDFNKGNIKARCRMIAQYALAGSHSGAVIGT
                     DHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLQKLGAEPALYEKIPTADLEEDK
                     PGLADEVALGVTYAEIDDYLEGKTISPEAQATIENWWHKGQHKRHLPITVFDDFWE"
     gene            complement(2080..3540)
                     /locus_tag="VVO18_001911"
     CDS             complement(2080..3540)
                     /locus_tag="VVO18_001911"
                     /EC_number="6.3.4.21"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016466109.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="HEU5586998.1"
                     /translation="MYPDDSLTLHTDLYQINMMQVYFDQGIHNKKAVFEVYFRQQPFK
                     NGYAVFAGLERIVNYLEDLRFSDSDIAYLESLGYHGAFLDYLRNFKLELTVRSAQEGD
                     LVFANEPIVQVEGPLAQCQLVETALLNIVNYQTLVATKAARIRSVIEDEPLMEFGTRR
                     AQEMDAAIWGTRAAVIGGANGTSNVRAGKLFDIPVLGTHAHALVQVYGNDYEAFKAYA
                     ATHKNCVFLVDTYDTLRIGVPAAIQVARELGDQINFMGVRIDSGDIAYISKKVRQQLD
                     EAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVAIE
                     DETGQMHNTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITYDGVDISDMTEIKM
                     FHPTYTYIKKTVRNFDAVPLLVDIFKEGILVYNLPSLTDIQDYARKEFDKLWDEYKRV
                     LNPQHYPVDLARDVWQDKMDLIDKMRKEALGEGEEE"
     gene            complement(3656..4144)
                     /locus_tag="VVO18_001912"
     CDS             complement(3656..4144)
                     /locus_tag="VVO18_001912"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000797183.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5586999.1"
                     /translation="MKNRFYYYQLLDEREEQLINKAGSESFYICIALSLLSYIISVLA
                     PSLFNSNMLLIVIIIGTFYFFNRARYLGVTYYSRFHFTILGCFFLTLAITALLMLQNY
                     QFNIEIYQHNPLNFKYLSAWVITYVIYLPWVFIGNLGLKSYGEWAQKKFEQDMDELES
                     GE"
     gene            complement(4134..4343)
                     /locus_tag="VVO18_001913"
     CDS             complement(4134..4343)
                     /locus_tag="VVO18_001913"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013670190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="HEU5587000.1"
                     /translation="MAKNLKLKLARVERDLTQGQLAEAVGVTRQTIGLIEAGKYNPSL
                     SLCQSICRCLGKTLDQLFWEEEDEK"
BASE COUNT         1313 a         1058 c          844 g         1371 t
ORIGIN      
        1 catcagaatg agactatttt aatattagat attttgatag aaaaaaacat aaataaaatt
       61 ggttgaattt aattccctaa ctcgatagag gattctattt taaatttaac aacagctagg
      121 attacactat aaaaagcaca ttaccacctg ttcggctgga gaatctagtc gattagctcc
      181 ctcttagtta caagcttcaa gcgatttttt aactaatact aaaccagatt aaagaagaaa
      241 ctagaacatc tgtcttgtac taatcaatat gctattttaa agttgcaaat aaacttggaa
      301 tgctaattat tatatttaca ataaatagtt gacttcgata gaaacagaaa atagaattca
      361 acattcttcc ctacttatac cataataaat aagatccgca agatagcctt ttctctctac
      421 accattaaca atggtttgta gataggacat tccagccttt tccatgacac gacctgaagc
      481 tgggttgaga ctggcataac gtgctctgac cttttgaaaa cctgcttgag taaaacaaaa
      541 gtccaagaca gctttcaagg cctctgtcat cataccatgt ccccagtaag ccttgcctag
      601 cacatagcca atttcacagc ttaaatcagc ctcgtctatc ttaacaatgc tgatatctcc
      661 tatcacttgc tctgggtttt cttttagaca aatggcccat ttgtaatagt tgagattagt
      721 ataggaagca acccaattgc gaatcgagtt tcgagtgatt tcgacatcag gatggggatc
      781 ccaggtaaca taggtcaaat tctcagcgga tgaagcccaa ttttgaaaca tggcttctgc
      841 atcactctcc acaaatcttc ttaaaatcaa acgttctgtc tgtaatattt gcgtaccgat
      901 agatttcatg atgctacctc acttccttat ttctatgctc gtagtaaaaa gactcaactc
      961 agtaacagct agaaaacgag tttgtcttct aatttcttga cgcagtcgct gcctggtttg
     1021 aaatgcgctc tagcaagctt tttcaaacct agtcatcgtt gcaggggtaa gacgatgaaa
     1081 tcgaactctt cgagttactg aatctgcctc attttcttat ttctaaactc ggggttcaag
     1141 atcccccaga ccttctctca ctttcttatt tcaagatgag aggctgaaaa cctccagtgg
     1201 aggtttttct tgctttttaa tttcagggta agaagctaaa aaggtccccc ggaccttttt
     1261 actcccaaaa gtcatcaaat acggtgatgg gtaagtggcg tttgtgttgg cctttgtgcc
     1321 accagttttc aatggtcgct tgagcttctg ggctgattgt tttgccttct aggtagtcgt
     1381 caatctctgc gtaggtgact ccaagtgcga cttcgtcagc taggcctggt ttatcttctt
     1441 ctaggtctgc cgttgggatt ttttcataaa gggctggctc tgcgccaagt ttctgcaaga
     1501 gctgttttcc ttggcgttta ttgaggcggt aaagagggag aatatccgca ccgccgtcac
     1561 caaacttggt aaagaaacct gtgatatttt ccgcggcgtg gtctgttcca atgaccgctc
     1621 cgctatggga accagcaagg gcatactgag caatcatacg gcaacgtgcc ttgatattcc
     1681 ccttgttgaa gtctgaaaca ggactacctg tcgcttcaac tgcagctgtc atggcatcag
     1741 ctgattcctt gatattcaca accaagctga catctggctg gatgaaggct agggcttttt
     1801 gagcatctgc ttcatcagct tgcactccgt atggcaggcg gacagcgata aatttgtagc
     1861 tatcgtctcc cgtttcagct cgcagttctt ccatagctaa ttgcgccaaa cgtcctgcca
     1921 aggttgagtc ttgtccccca gaaatcccta gtacaaaggt ttttaggaag ggatgttttt
     1981 tcagatatct ttttaagaaa tcaatagaac gacggatttc ttcctgggca tcaatcactg
     2041 gtttgacacc cagctcttgg ataatcgttt cttgcaaact cattcttctt ctccttcacc
     2101 aagggcttcc ttgcgcatct tatcaatcaa gtccatctta tcttgccata catcacgcgc
     2161 caaatccact ggatagtgct gcggattgag cacacgctta tactcatccc acaacttgtc
     2221 aaattcctta cgggcataat cctgaatgtc agtcaaacta ggcaagttgt aaactaatat
     2281 tccttctttg aagatatcca ccaagagagg aacggcatca aaattacgaa ccgtcttctt
     2341 gatgtatgta taggtcggat ggaacatctt gatttctgtc atgtcgctaa tatccacacc
     2401 atcataagtg atgtagtcac cttctgactt gcctttttca cgactggtaa tgcgccacac
     2461 ctgcttctta cctggcgtcg acactttttc cgcattatta gacagcttaa tcgtattgtg
     2521 catctgacca gtttcatctt caattgcaac aatcttgtaa accgccccaa gagccggctg
     2581 gtcataggct gtaatcagct tggtacccac accccagaca tcaatcttgg ccttttgcat
     2641 cttgaggtta aggatggtat tttcatctag atcattagaa gcataaatct tagcctctgt
     2701 aaatccagcc tcgtccagtt gctgacggac tttcttagaa atgtaggcaa tatccccaga
     2761 gtcaatccgc acacccataa agttaatctg atcacccagc tcacgcgcca cctgaatggc
     2821 agctggtaca ccgatgcgaa gggtatcata ggtatccaca agaaagacac aatttttgtg
     2881 ggtcgcagcg taagccttga aagcctcata gtcattgcca taaacctgta ccaaggcatg
     2941 ggcatgggtt cccaaaacag gaatgtcaaa gagcttaccc gcacgcacgt tgctggttcc
     3001 attggcgcca ccaatcaccg ctgcgcgtgt tccccagatg gccgcatcca tttcttgagc
     3061 ccgacgtgtc ccaaactcca tcaagggttc atcttcgata accgaacgaa tacgagctgc
     3121 cttcgtcgcc accaaggtct ggtagttgac gatgttcaaa agagccgttt cgaccaactg
     3181 acattgggct agaggtcctt ccacctgcac aatcggttca ttagcaaaaa ccaaatcccc
     3241 ttcttgggca gaacgaacgg tcaactccaa cttgaaattg cgaaggtaat ccaagaacgc
     3301 cccatgataa ccaagcgact ccaaataggc tatatcacta tctgaaaaac gcaagtcttc
     3361 aagatagttc acaattcttt ccaaacctgc aaaaaccgca tagccgttct taaaaggctg
     3421 ttggcggaaa tacacctcaa agaccgcctt cttattgtga atcccttggt caaagtaaac
     3481 ctgcatcatg ttgatctggt acaagtccgt gtgcaatgtc aaactatcat ctggatacat
     3541 acttttccta cttccttagc tagaaaccca tgaaaatttt caagaacttt catgtattcc
     3601 aataaattag tactattata tcacatttta gctggattga gaaaagagta acaagctatt
     3661 ctccactctc caattcatcc atatcttgtt caaatttttt ctgagcccat tcgccatagc
     3721 tcttaagacc aagattgcca ataaagaccc acggaaggta aatgacataa gtaatgaccc
     3781 aagcagacag gtatttaaaa ttcaaaggat tgtgctgata aatttctatg ttgaattgat
     3841 aattctgcaa catcaaaaga gccgtaatag ccaaggttag gaaaaaacaa cccaaaatcg
     3901 taaaatgaaa acgactatag taggtcactc ccagataacg ggcacggtta aaaaagtaaa
     3961 atgtccctat gatgataacg attagcagca tattagaatt aaaaaggctt ggtgctaata
     4021 ctgaaatgat ataagatagg agcgacaaag cgatgcagat atagaaactt tcagagcccg
     4081 ctttattgat cagttgttct tctctttcgt ctagtaattg ataataataa aatctatttt
     4141 tcatcttctt cctcccaaaa tagttggtct agggttttcc ctaaacatct gcaaatagac
     4201 tggcagagcg agagactggg attgtatttt cccgcctcta tcaaaccaat agtctggcgt
     4261 gtcaccccga cagcctctgc cagttgacct tgtgttaaat cacgctctac ccgagctaat
     4321 tttaatttta aatttttagc caccttcgtc ctccttatag ttttaatact catctactct
     4381 taaaaaatcc aaaaccaaca caagctatca gctatttatt ataaccccat taatttgcac
     4441 tccagtatta tcttcagccg aaaatcagta ttttaggttg tttgaaataa acttcctagt
     4501 ttactctttt atttttattt agtattagct ttagtaggat cttttaaacg agtttttatt
     4561 gcttatattt cttgtttagt ttagtt
//
LOCUS       DAVHIZ010000085         4364 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.087, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000085 DAVHIZ010000000
VERSION     DAVHIZ010000085.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4364)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4364)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4364
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.087"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1011
                     /locus_tag="VVO18_001914"
     CDS             <1..1011
                     /locus_tag="VVO18_001914"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790748.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="HEU5587001.1"
                     /translation="FLIAILAMCIVFSACSSNSVKNEENTSKEHAPDKIVLDHAFGQT
                     ILDKKPERVATIAWGNHDVALALGIVPVGFSKANYGVSADKGVLPWTEEKIKELNGKA
                     NLFDDLDGLNFEAISNSKPDVILAGYSGITKEDYDTLSKIAPVAAYKSKPWQTLWRDM
                     IKIDSKALGMEKEGDELIKNTEARISKELEKHPEIKGKIKGKKVLFTMINAADTSKFW
                     IYTSKDPRANYLTDLGLVFPESLKEFESEDSFAKEISAEEANKINDADVIITYGDDKT
                     LEALQKDPLLGKINAIKNGAVAVIPDNTPLAASCTPTPLSINYTIEEYLNLLGNACKN
                     AK"
     gene            1001..2008
                     /locus_tag="VVO18_001915"
     CDS             1001..2008
                     /locus_tag="VVO18_001915"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244688.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU5587002.1"
                     /translation="MRNKKQINLGIIFVICLGLLITIFLSLKLGTKEINIRDFLAAFG
                     MGNTNDDFIKSIIYKRIPRTIFAILAGSSLAISGVLMQSVTRNPIADPGILGINTGAS
                     LSVVIALSFLGISSSISHISFAIIGGLVSAIFVYAIAVSGKAGLTPIKLALSGTCVSM
                     ALSSFVSFLILPNNNVLDKFRFWQIGSLGAATLSSISTLLPFIILGHLIAIFISSDLN
                     ALAMGDEMAVGLGVNVNRIRSLAIIASVLLCSSITAIGGPIGFVGLIVPHFCGLFISK
                     DIRTMTISSSFIGAELLLICDIIGRMLGKPGEIEVGIITAIIGGPVLIYVTMKNRGVN
                     N"
     gene            2008..3015
                     /locus_tag="VVO18_001916"
     CDS             2008..3015
                     /locus_tag="VVO18_001916"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001180354.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="iron ABC transporter permease"
                     /protein_id="HEU5587003.1"
                     /translation="MQNLIIGIQKRKNRITLFSSLFLLIIISLSFFILLIGDESYSFS
                     TLIKVLNSETVPGASFSIMEIRLPKLLAGIIAGWSFGLAGFIFQTMLRNPLASPDIIG
                     VTSSSSIAAVFCILVLKTNSLTTGIISITCGLTSSLILFLLAKKDGFSAARLIILGIG
                     FQAVTRAGTSFLLLKVARYELQEVMRWLSGSLSFTKLDDIPLVLIVSIIATILVLFFN
                     KRLEIIELGEEIAIGLGANPELSRLVLIFCAVSLTAFSTSITGPIACISFLAGPIALN
                     IGKKRSPILAGLVGILLVLLSDIFSQNILPARYPVGVVTGLLGSPYLIYLLIKMNRRN
                     I"
     gene            3015..3809
                     /locus_tag="VVO18_001917"
     CDS             3015..3809
                     /locus_tag="VVO18_001917"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000677523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587004.1"
                     /translation="MKGLWSNNLTCGYDEKIILENINIKIPEEKISVIIGSNGCGKST
                     LIKTLSRLIKPLEGEVLLDNKSINSYKEKDLAKHIAILPQSPIIPESITVADLVSRGR
                     FPYRKPFKSLGKDDLEIINRSMVKANVEDLANNLVEELSGGQRQRVWIALALAQDTSI
                     LLLDEPTTYLDISYQIELLDLLTDLNQKYKTTICMILHDINLTARYADYLFAIKEGKL
                     VAEGKPEDILNDKLVKDIFNLEAKIIRDPISNSPLMIPIGKHHVSS"
BASE COUNT         1579 a          641 c          742 g         1402 t
ORIGIN      
        1 tttctaatag ctattttagc tatgtgtata gtttttagcg cttgttcttc taattctgtt
       61 aaaaatgaag aaaatacttc taaagagcat gcgcctgata aaatagtttt agatcatgct
      121 ttcggtcaaa ctatattaga taaaaaacct gaaagagttg caactattgc ttggggaaat
      181 catgatgtag cattagcttt aggaatagtt cctgttggat tttcaaaagc aaattacggt
      241 gtaagtgctg ataaaggagt tttaccatgg acagaagaaa aaatcaaaga actaaatggt
      301 aaagctaacc tatttgacga tttggatgga cttaactttg aagcaatatc aaattctaaa
      361 ccagatgtta tcttagcagg ttattctggt ataactaaag aagattatga cactctatca
      421 aaaattgctc ctgtagcagc atacaaatct aaaccttggc aaactttatg gagagatatg
      481 attaaaattg attcaaaagc cttaggtatg gaaaaagaag gtgatgagtt aatcaaaaat
      541 actgaagctc gtatatccaa agaattagaa aaacatccag aaatcaaagg aaaaatcaaa
      601 ggaaaaaaag tattatttac tatgattaat gctgcagata catcaaaatt ctggatttat
      661 actagcaaag atccaagagc aaattattta acagatttag gtctagtttt ccctgaatca
      721 ttaaaagaat ttgagagtga agatagtttt gcaaaggaaa tttctgcaga agaagcaaat
      781 aagataaatg atgctgatgt aatcataact tatggtgatg ataaaactct tgaagcttta
      841 caaaaagatc ctcttttagg taaaataaat gcaattaaaa atggtgccgt tgctgtaatt
      901 ccagataata caccgttagc agcctcatgc actccaacac cactttcaat aaactatact
      961 attgaagaat acctaaatct tttaggaaat gcatgcaaaa atgcgaaata aaaaacaaat
     1021 aaacctaggc ataatttttg taatctgcct aggtcttctt attacaatat ttttgtcatt
     1081 aaagcttgga acaaaagaaa ttaatatcag agatttttta gcagcttttg gaatgggtaa
     1141 tacaaatgat gattttatta aatcaattat atataaaaga atacctagaa ctatttttgc
     1201 aattttagca ggttctagtc ttgccataag cggtgtgttg atgcaatcag ttactagaaa
     1261 cccaatagct gatccaggta tactcggtat aaacacagga gcaagtctta gtgtagtaat
     1321 tgctctttct tttttaggaa tttcatcaag cataagccat ataagttttg caatcattgg
     1381 tggcttagta agtgcaattt ttgtatacgc gattgctgta agcggaaaag caggccttac
     1441 ccctataaaa ctagccttat caggaacttg tgttagtatg gctttaagca gttttgtaag
     1501 ttttttaatt ttaccgaata ataacgtctt agacaaattt agattttggc aaataggtag
     1561 ccttggagca gctacattat cttctatatc tacactacta ccttttataa ttttaggtca
     1621 cttgatagct atatttattt catcagattt aaacgcttta gctatgggtg atgaaatggc
     1681 tgttggtctt ggagttaatg ttaataggat aagatcactt gcaataattg caagtgtgct
     1741 tttatgttca agtattactg caattggtgg acctattggc ttcgtaggtc ttatagttcc
     1801 tcacttttgt ggcttattta taagcaaaga tatacgcaca atgaccattt cttcatcttt
     1861 tataggtgca gagctcttgc ttatatgtga tataatcggc cgtatgttag gtaaaccagg
     1921 tgaaattgaa gtagggataa ttactgcaat aatcgggggt ccagtactta tttatgtaac
     1981 tatgaaaaat agaggggtta ataactaatg caaaatttaa ttataggtat tcaaaaaaga
     2041 aaaaatagaa taacactatt ttcctcacta tttttattaa taataatcag tctatcattt
     2101 ttcattttac ttatcggaga tgaaagttat tctttttcaa ctttgattaa agtcttaaat
     2161 agtgaaactg ttcctggagc tagtttttcg attatggaaa ttagattacc aaaattatta
     2221 gcaggaatta tagctggctg gtcttttgga ttggcaggat ttatctttca aactatgtta
     2281 agaaatcctc ttgcaagtcc tgatataatc ggtgtcacaa gttcttcatc tattgcagcg
     2341 gtcttttgca tattggtatt aaaaacaaat agtttaacta ctggaattat ttcaataact
     2401 tgtggactaa catcatcttt aatattattt ttactagcta aaaaagatgg tttttcagca
     2461 gcaagactga taatattagg tattggtttt caagctgtca caagagcagg cacctcattt
     2521 ttattgttga aagtagcaag atatgaatta caagaagtta tgagatggct cagtggctct
     2581 ttatctttta caaagttaga tgacatacct cttgttctaa tagtaagtat tattgctact
     2641 atattagttt tattttttaa taaaagacta gaaattattg aacttggtga agaaatagca
     2701 atcggacttg gagcaaatcc cgagctttca aggcttgttt taattttttg cgctgtatct
     2761 ttaactgctt tttctacttc aattacagga ccaatagctt gtatatcttt tttagctggt
     2821 cccatagcct taaatattgg caagaaaaga agcccaatat tagctggatt ggttggaatt
     2881 ttactagttt tgttatcaga catattctct caaaatattt taccagctag atatccagta
     2941 ggtgttgtaa ctggcttgtt aggttcacca tacttaatat acttactaat aaaaatgaac
     3001 aggaggaata tataatgaaa ggtctgtggt caaataatct tacctgcggt tatgatgaaa
     3061 aaataatctt ggaaaatata aatataaaaa tacctgaaga aaaaatatca gttattattg
     3121 ggtcaaatgg ttgtgggaaa tcaacactca ttaaaacctt gtctcgactt ataaagccat
     3181 tagagggaga agtattgctc gataataaat caattaattc ttataaagaa aaagatttag
     3241 caaaacacat agctatatta cctcaatctc caataatccc tgaatcaata acagtagctg
     3301 atcttgtaag ccgtggtcgt ttcccctaca gaaagccttt taagagtctt ggaaaagatg
     3361 accttgaaat aataaacaga tcaatggtta aggccaatgt tgaagatcta gcaaataacc
     3421 tagttgaaga actttctggg ggtcaaaggc aaagagtatg gatagctcta gccctagccc
     3481 aagatacaag tatcctactt ttagatgagc caactactta cttggatatc tcatatcaaa
     3541 tagaactatt agacctcttg actgatctaa accaaaaata taagacaacc atttgcatga
     3601 ttttgcacga tataaatcta acagcaagat acgctgatta cctatttgca attaaagaag
     3661 gtaaacttgt tgcagaggga aagcctgaag atatactaaa tgataaacta gttaaagata
     3721 tctttaatct tgaagcaaaa attatacgtg accctatttc caattcgcct ctaatgattc
     3781 ctattggcaa gcaccatgtt agctcttaat aattgaatat tggaattcat ttaaaagtcg
     3841 caaattttga actgaccctc aaaagttagg ccaaaaaact aactaaagga ggtcagtttt
     3901 ttaatggcaa atacagcaca gaatttaaga taaaattagt aaaagaatat catgaatgaa
     3961 aaataggata tagagaataa cagcaatatt aaaaagatca ggactgataa taaacaaaaa
     4021 gaaagtacaa cgactagttc aaaagctaaa acttcaagta aaaagttatt caagaaaatc
     4081 tagaaaatac tcatcctaca aaggacaggt aggaaaaata tcagacaaca aaataaaaag
     4141 aaatatttat taccgaaaaa aaggggaaat cgagtcaagt accaacaggc tcatctattc
     4201 caaaaagata tttactcgat ggaaaaactc ctagaattag tgctacaaat attgacaatg
     4261 gtatcttagg ttactacgaa gatatagatg ataaaaatta tagagttttt gaaaatttta
     4321 tatctgtttc attattaaat taccgataga cagtagaggt actc
//
LOCUS       DAVHIZ010000086         4355 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.088, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000086 DAVHIZ010000000
VERSION     DAVHIZ010000086.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4355)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4355)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4355
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.088"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            427..618
                     /locus_tag="VVO18_001918"
     CDS             427..618
                     /locus_tag="VVO18_001918"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich KTR domain-containing protein"
                     /protein_id="HEU5587005.1"
                     /translation="MTSKLTASTCPVCGNKTRLKIREDTELKKFPLYCPKCRQENLIE
                     IKQFKVTVITEPDAKTQSR"
     gene            complement(678..1031)
                     /locus_tag="VVO18_001919"
     CDS             complement(678..1031)
                     /locus_tag="VVO18_001919"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5587006.1"
                     /translation="MRKKEDKYDFRAFGLAIKEARLKRGLTREQVGALIEIDPRYLTN
                     IENKGQHPSIQVLYDLVSLLHVSVDEFFLPANNLVKSTRRLQIEKYMDSFTDKELSLM
                     ESLASGINEARNIED"
     gene            1536..1958
                     /locus_tag="VVO18_001920"
     CDS             1536..1958
                     /locus_tag="VVO18_001920"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006733729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU5587007.1"
                     /translation="MKPSSFQTTIENQFDYICKRAMEDERKNYMLYLSRIAKREVSFS
                     DVGDYLVSQFATTDNYSTDFQIFTLNGLSVGVENDLLSEALRELPDKKREILLLFYFM
                     DMSDSEIADLLKLNRSTVYRHRTSGLALIKKFMEEFEE"
     gene            1955..2185
                     /locus_tag="VVO18_001921"
     CDS             1955..2185
                     /locus_tag="VVO18_001921"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002411750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5587008.1"
                     /translation="MKTQYPMIPFPLIVKATDGDTEAINQILHHYRGYITKRSLRLMK
                     DEYGNQSMVVDEVLRGRMETRLITKILSFEIK"
     gene            2646..2849
                     /locus_tag="VVO18_001922"
     CDS             2646..2849
                     /locus_tag="VVO18_001922"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006730246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HEU5587009.1"
                     /translation="MKQTDIPIWERYTLTIEEASKYFRIGENKLRRLAEENKNANWLI
                     MNGNRIQIKRKQFEKIIDTLDAI"
     gene            2931..4148
                     /locus_tag="VVO18_001923"
     CDS             2931..4148
                     /locus_tag="VVO18_001923"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU5587010.1"
                     /translation="MSEKRRDNKGRILKTGESQRKDGRYLYKYIDSFGEPQFVYSWKL
                     VATDRVPAGKRDCISLREKIAELQKDIHDGIDVVGKKMTLCQLYAKQNAQRPKVRKNT
                     ETGRKYLMDILKKDKLGVRSIDSIKPSDAKEWAIRMSENGYAYQTINNYKRSLKASFY
                     IAIQDDCVRKNPFDFQLKAVLDDDTVPKTVLTEEQEEKLLAFAKADKTYSKNYDEILI
                     LLKTGLRISEFGGLTLPDLDFENRLVNIDHQLLRDTEIGYYIETPKTKSGERQVPMVE
                     EAYQAFKRVLANRKNDKRVEIDGYSDFLFLNRKNYPKVASDYNGMMKGLVKKYNKYNE
                     DKLPHITPHSLRHTFCTNYANAGMNPKALQYIMGHANIAMTLNYYAHATFDSAMAEMK
                     RLNKEKQQERLVA"
BASE COUNT         1493 a          771 c          836 g         1255 t
ORIGIN      
        1 atcgatttga agttgcctaa attattactt attcggtaaa atgaagtatt gctttcaaca
       61 gatttccttc aactacactt cacttgattc aaacaaggtg ggtacatttc tattcccaca
      121 aactccttgt caatggaaac aaacacgtac ccacagggta aatggaaata gaaactgata
      181 atttctagct atcacttcta ctcattccaa aaattttctc actctgatac ttacccacca
      241 taaagcaaaa agccttgcaa tcaaggcttt cattatccct ttcgttcaaa ggtttctaag
      301 cttttacgag cagagcgaca cactcagcgg ttcgctatct ccgttctgtc tgcgtgctag
      361 cacttgtcaa tcacggacag ctatcgcatg ggcggaagta aatgctaatc ttcgtcgttt
      421 tactccttga ctagcaaact taccgcctca acatgtcctg tatgtggaaa taaaacacga
      481 ttaaagataa gggaagatac tgaattaaaa aaattccccc tctattgtcc gaaatgcaga
      541 caagaaaatt taattgaaat aaagcagttc aaagtaactg tgattacaga gccagacgca
      601 aagacgcaga gccgataaaa tgagattaat acaatctcat tttatcggct ctttccgtta
      661 tgtatggatt cttttaatta gtcttcgatg tttcttgctt cgttgatacc gctggctaaa
      721 gattccatta aggatagttc tttgtctgta aagctatcca tgtatttctc tatctgtaat
      781 cgtcgggtgc tttttaccaa gttattagca ggtaagaaaa attcatcaac ggaaacatga
      841 agtaacgata caaggtcata aagaacttgt atgctggggt gttgcccttt attttcaata
      901 ttagttaagt accgtgggtc aatttcaatc aatgctccca cttgttcacg agttaaacct
      961 cgtttcaatc gagcttcttt aatggctaaa ccaaaggctc taaaatcata tttatcttct
     1021 tttttacgca tagtagacca cctctataca ttttattgtt cctactgaat taaaaacagg
     1081 tatagaaaaa cgtgttatat ggtttatagg tttatattta ataaaaagca ctactaaacg
     1141 ccaataaaaa aaaccgttat atggtagtgc tatttacgct gttaaaatat tgtatattac
     1201 ttccaaatgg cggtttgttg gaggtcaacg tcgccatgaa gtacatcata tacaataaat
     1261 ttccttacat tgggttcttg tcaaaaaaag tcgtctatct gcaatagata agtacgtcca
     1321 ccaatgtggt tttataaatc atatagatag aataacagaa gcatgtaaac agagaaataa
     1381 atctgtttat atgctttttt ggctattcag aactttttta caaagtttat ttatcagtaa
     1441 tgcaacaaat ccccctttca cattgggact aagagtgaaa ggagataaac gagcaaggct
     1501 cacttccttt cctagacaga aagggggtga gaaacatgaa accatcttct tttcagacca
     1561 caatagaaaa tcagtttgac tatatctgta aacgtgctat ggaagacgag cgaaagaatt
     1621 atatgcttta tctttcaagg attgcaaagc gtgaggtgtc cttttcggat gttggcgatt
     1681 atcttgttag ccagtttgcg acaacagata actattcaac tgactttcag atttttacac
     1741 tcaatgggtt atcagtaggc gttgaaaatg atttgttgag tgaagcatta cgtgagttgc
     1801 cagacaagaa acgtgaaatt ctactgctgt tttactttat ggacatgagc gattcagaaa
     1861 ttgcagacct gttgaaattg aaccgttcta ctgtctatcg gcatagaacc agtggactag
     1921 ccttaattaa aaagtttatg gaggaatttg aagaatgaaa acacaatatc ctatgattcc
     1981 ctttcctctc attgtaaagg caacagatgg cgataccgaa gcgattaacc agattctaca
     2041 tcattacaga gggtacataa cgaagcgttc cctacgactt atgaaagatg aatatggcaa
     2101 tcaaagtatg gtcgttgatg aagtcttacg tggaagaatg gaaaccagac tgattacaaa
     2161 gattttgtca tttgaaatta agtaatatcc tctctccttt cgtggaagcg tgctaaacca
     2221 ttccacgctt cccgaacagg gaggtttgtt attccaccaa agcatattga gctttcaatg
     2281 tgttttgata ggctaacgag ccattgttct ttgaaaactg aataaaagta atcgaatacg
     2341 tttcgataag aaaagagcca acggaactaa ccgccatgac ctatcttata aagatagcga
     2401 gcgattcatg ttagtgatcc gagaagcaat ctttagcagg attgcctgca acgacattct
     2461 tatcgtgata atgatactcc catacagtca atagtccgag cgtgataaaa ccgtcgcagg
     2521 caatgagtat ggctacatga gaaccatgca ggggtggaac tcccgtgagc tttgctaaag
     2581 ctgttcgatt gctggtaaaa caacttttat gaaatccaaa taagtgattt ggaaaggagg
     2641 attttatgaa gcagactgac attcctattt gggaacgtta taccctaacc attgaagaag
     2701 cgtcaaaata ttttcgtatt ggcgaaaaca agctacgacg cttggcagag gaaaataaaa
     2761 atgcaaattg gctgattatg aatggcaatc gtattcagat taaacgaaaa caatttgaaa
     2821 aaattataga tacattggac gcaatctagc gtcgccaaag ggtcttgtat atgataaaat
     2881 agtattaagt cgtatcaagg ctctttccat aaaggaaagg agcaaatgcc atgtcagaaa
     2941 aaagacgtga caataaaggt cgaatcttaa agactggaga gagccaacga aaagacggaa
     3001 gatacttata caaatatata gattcatttg gagaaccgca atttgtttac tcgtggaaac
     3061 ttgtggctac agaccgagta ccagcaggaa agcgtgattg tatctcactt agagagaaaa
     3121 tcgcagagtt acagaaagac attcatgatg gtattgatgt tgtaggaaag aaaatgacac
     3181 tctgccagct ttacgcaaaa cagaacgctc aaagaccaaa ggttagaaaa aacactgaaa
     3241 ctggacgcaa atatcttatg gatattttga agaaagacaa gttaggtgta agaagtattg
     3301 acagtattaa gccatcagac gctaaagaat gggctattag aatgagtgaa aatggttatg
     3361 cttatcaaac catcaataac tacaaacgtt ctttaaaggc ttcattctat attgctatac
     3421 aagatgattg tgttcggaag aatccatttg actttcaact gaaagcagtt cttgatgatg
     3481 atactgtccc taagaccgta ctaacagaag aacaggaaga aaaactgtta gcctttgcaa
     3541 aagctgataa aacctacagc aaaaattatg atgaaattct gatactctta aaaacaggtc
     3601 ttcgtatttc agagtttggt ggtttgacac ttccagattt agattttgag aatcgtcttg
     3661 tcaatataga ccatcagcta ttgagagata ctgaaattgg gtactacatt gaaacaccaa
     3721 agaccaaaag tggcgaacgt caagttccta tggttgaaga agcctatcaa gcatttaagc
     3781 gagtgttagc gaatcgaaag aatgataagc gtgttgagat tgatggatat agtgatttcc
     3841 tctttcttaa tagaaagaac tatccaaaag tggcaagtga ttacaacggc atgatgaaag
     3901 gtcttgttaa gaaatacaat aagtataacg aggataaatt gccacacatc actccacata
     3961 gtttgcgaca tacattctgt accaactatg caaatgcagg aatgaatcca aaggcattac
     4021 agtacattat gggacatgct aatatagcca tgacgctgaa ctattacgca catgcaacat
     4081 tcgattctgc aatggcagaa atgaaacgct tgaataaaga gaagcaacag gagcgtcttg
     4141 ttgcttagta gtacaaatga atttactact tatttaccac ttctgacagc taagacatga
     4201 ggaaatatgc aaagaaacgt gaagtatctt cctacagtaa aaatactcga aagcacatag
     4261 aataaggctt tacgagcatt taagaaaata taaaaagata attagaaatt tatactttgt
     4321 ttattttaaa gaagtgattc taatgtacaa gggtg
//
LOCUS       DAVHIZ010000087         4291 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.089, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000087 DAVHIZ010000000
VERSION     DAVHIZ010000087.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4291)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4291)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4291
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.089"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            61..900
                     /locus_tag="VVO18_001924"
     CDS             61..900
                     /locus_tag="VVO18_001924"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006270038.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PRD domain-containing protein"
                     /protein_id="HEU5587011.1"
                     /translation="MIIKRILNHNAVIAQSKKDIDILLFGRGIAFGRKTGDKVNPIDI
                     EKSFFLKNRDNMTRFTEMFINVPLELVYITEKIINLGKITLGNNFDEIIYINLTDHIS
                     SSIERYKEGVIISNPLRWEISKYYKEEFELGKRALQIIKKELGIELPIDEAAFIALHF
                     VNANLENNFQESYKITEIIMGIEKIIQDFYCTEFNQDSIDYYRFITHIKLFAHRLVEN
                     TTYCDDDDEDLLALMKNKYPREYECGEQVAMFIQTEYNYLLTSSELVYLMAHIRRLTK
                     NLD"
     gene            918..2756
                     /locus_tag="VVO18_001925"
     CDS             918..2756
                     /locus_tag="VVO18_001925"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120564.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS glucose transporter subunit IIA"
                     /protein_id="HEU5587012.1"
                     /translation="MSYKDTVQKILDVIGGEKNVNRVTHCVTRLRLELKDENLVNDDD
                     VKKIPGVIGIMKKNGQYQIILGNDVANYYKEFVKLGNFESDSVNQGYKGNILERIIEY
                     IAGSMTPIIPAMLGGGMLKVLVIILPMLGILQSDSQTIAFLTFFGDAPYYFLPLLLAY
                     SASQKLKVTSTLAMSVAGVLLHPNFVQMVQSGNPLSLFGAPVTPASYGSSVVPILIMV
                     WLMKYIEKIIAKLTPAITKSFLQPTLVLLVSSCIALVVVGPIGVIVGEGLSNLVGQMY
                     GVAGWLTLAILGAIMPFIVMTGMHWAFAPIFLAASIATPDVLILPAMLGSNLAQGAAS
                     MAVALKSKNNNTKQIAFAAGFSALLAGITEPALYGVTLKYKKPLYAAMIGGGLAGLFA
                     GLTSVKAYLFAVPSLIALPQFIYSDVPSNIVNALIVAVISVVITFVLAYIFGIDEEES
                     SSNLEVEAGVSNKKMIFSPISGEIIPLSDVQDKTFSDKLIGDGVAIIPSEGKVYAPFD
                     GKITNIFPTKHAIGLKSDEGVELLIHIGLDTVELKGQGFISHVEEGDRVFKNQLIFEM
                     DLNLIKTKGYETVTPVIVTNTNDFLDVLVLPNNQTIEHSKELLVIL"
     gene            2769..4184
                     /locus_tag="VVO18_001926"
     CDS             2769..4184
                     /locus_tag="VVO18_001926"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000151865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycoside hydrolase family 1 protein"
                     /protein_id="HEU5587013.1"
                     /translation="MTIFPDDFLWGGAVAANQVEGAYNEDGKGLSVQDVLPKGGLGEA
                     TENPTEDNLKLLGIDFYHKYKEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGL
                     KYYDELFDELHAHGIEPLVTLSHYETPLYLARKYHGWIDRRMIHFYEKFARTVLERYK
                     DKVKYWLTFNEVNSVLELPFTSGGIDIPKENLSKQELYQAIHHELVASSLVTKIAREI
                     NSEFKVGCMVLAMPAYPMTPNPKDVWATHEYENLNYLFSDVHVRGYYPNYAKRYFKEH
                     DINIEFAAEDAELLKNYTVDFLSFSYYMSVTQSALPTQYNSGEGNIIGGLVNPYLESS
                     EWGWQIDPIGLRIILNRYYDRYQIPLFIVENGLGAKDQLIKDEFNNLTVQDDYRIQYM
                     EEHLLQVAEALQDGVEIMGYTSWGCIDCVSMSTAQLSKRYGLIYVDRNDDGNGTFNRY
                     KKMSFTWYKGVIESNGESLFK"
BASE COUNT         1452 a          565 c          842 g         1432 t
ORIGIN      
        1 atcggaagaa gtttcttgat gtttttaagc aggttccttt tattttaaaa gggaaatttt
       61 atgatcataa aacgaatact aaaccacaat gccgtaattg cgcaaagtaa aaaagatatc
      121 gatattcttc tttttggaag gggaatagct tttggaagaa aaactggaga taaagtaaat
      181 ccaattgata ttgagaaaag tttttttctc aaaaatagag ataatatgac ccgttttaca
      241 gagatgttta ttaacgttcc tttggagttg gtgtacatca ccgaaaaaat aattaaccta
      301 ggtaaaataa cattgggtaa taattttgat gaaattatct atattaattt aacggatcat
      361 atttcttcga gcatagaacg ttataaagaa ggagttatta tttcgaatcc cctacgctgg
      421 gaaatctcga aatattataa agaagaattt gaacttggga aaagggcttt acaaataata
      481 aaaaaagagt taggtattga acttccaatt gacgaagctg cattcatagc gctacatttt
      541 gttaatgcta atttagaaaa taattttcaa gagtcgtata aaatcactga aataattatg
      601 ggaattgaga aaatcattca agatttctat tgtactgagt ttaaccaaga ttctattgat
      661 tattatagat tcataactca tataaaatta tttgcccatc gcttggttga aaatacaact
      721 tattgtgacg atgatgatga agacttgtta gcattaatga aaaataaata tcctagagaa
      781 tatgaatgtg gtgaacaggt ggcaatgttt atacaaactg agtacaatta tttgctgact
      841 tctagtgaat tagtttattt gatggctcat attcgtcgct taacaaaaaa tttagattaa
      901 tagaatagga gaataccatg agttataaag atacggtaca aaaaatcctc gatgtaattg
      961 gaggtgaaaa aaatgtcaat agagttaccc attgtgtaac acgtttaaga ttagaattaa
     1021 aagatgaaaa tttagtcaat gatgatgatg tgaagaagat accaggtgta ataggtatta
     1081 tgaaaaaaaa tggacaatat caaattatac ttggtaatga tgtagctaat tattataaag
     1141 aattcgttaa acttggcaat tttgaatccg attcagttaa tcaagggtac aaagggaata
     1201 ttttagaaag aatcattgag tatatcgctg gttccatgac tccaatcatt ccagcaatgt
     1261 tagggggagg tatgctgaaa gtcttggtaa ttattttacc aatgcttggt atattgcaat
     1321 cagattctca gactattgct tttttgacat tttttgggga tgctccatat tatttcttac
     1381 cgctgttatt agcttattct gcatcacaaa aattaaaagt aacatctaca ttagctatgt
     1441 ctgtagcagg tgtacttctc catccaaatt ttgttcaaat ggtgcaatca gggaatcctc
     1501 ttagtttatt tggtgcacct gtgacaccag ctagttatgg ttcatcagtc gttccaattc
     1561 ttattatggt ttggttgatg aaatatattg aaaaaataat tgctaaatta acaccagcta
     1621 ttactaagag ttttttgcaa cctacgctag tattattagt atcaagctgt attgccttag
     1681 ttgtagtcgg acctattgga gtaattgttg gtgaaggatt atcaaatcta gttgggcaaa
     1741 tgtatggtgt agctggatgg cttacattag ctattcttgg tgctattatg ccatttattg
     1801 ttatgactgg aatgcattgg gcttttgcac ctattttttt ggcggcatct attgctactc
     1861 cagacgtatt aattcttcca gcaatgttag ggtcaaactt agctcaaggg gctgcttcga
     1921 tggctgttgc attaaagagt aaaaataata atacaaaaca aattgctttt gcagcaggtt
     1981 tctcagcctt acttgcaggg attaccgaac ctgcattata tggtgtgact ttaaaatata
     2041 aaaaaccgct ttatgcagct atgattggtg gtggattagc gggattattt gcaggtctta
     2101 ctagtgttaa agcatatcta tttgctgtcc catctttgat agcgttgcct caatttattt
     2161 attctgatgt gccatcaaat attgtaaatg ctttaattgt ggcggtcatt tcggttgtta
     2221 ttacctttgt attagcttat atatttggaa tcgatgaaga agagagttct agcaatttag
     2281 aagttgaagc tggagtttca aataaaaaaa tgatattttc tcctatatca ggagaaatca
     2341 ttccgttaag cgatgtccag gataaaacat tttcagataa actaattgga gacggagtag
     2401 cgattatccc aagtgaaggt aaggtttatg caccatttga tgggaaaatt acaaatattt
     2461 ttccgactaa gcacgcaatt ggattgaaga gtgatgaggg tgttgagtta ctaattcata
     2521 ttggattaga tactgttgag ctaaaaggtc aaggttttat tagtcatgta gaagaaggag
     2581 acagagtttt caaaaatcag ttgatttttg aaatggactt gaatttaatc aagactaaag
     2641 gctacgaaac agttacacca gtaattgtaa cgaataccaa tgattttcta gatgtattag
     2701 tattacctaa taatcagaca atcgagcatt ctaaggaatt actggtaata ttataatgga
     2761 ggaaagttat gaccattttt ccagatgatt ttctttgggg tggagcggtt gcagctaatc
     2821 aagtagaggg agcatataat gaagatggta agggattatc agttcaggat gtgttaccca
     2881 aaggtggatt aggagaagca acagaaaatc ctacagaaga taacttaaaa ttgttaggta
     2941 ttgattttta tcataaatat aaggaagata tatccttgtt ttctgaaatg ggctttaatg
     3001 tttttcgtac ttctattgca tggagtagaa tttttccaaa aggagatgaa gaagaaccta
     3061 acgaagctgg gttgaaatat tatgatgaat tatttgatga actacatgct cacgggatag
     3121 aaccacttgt aactctttca cactatgaga ctccattata tttagcaaga aaatatcatg
     3181 gatggattga taggagaatg attcattttt atgaaaaatt tgctcgaaca gttttagaaa
     3241 ggtataaaga taaagttaaa tattggctta catttaacga agtaaactct gttttggaat
     3301 taccgtttac tagtggagga atagatatac ctaaggagaa tctttcgaaa caagaattat
     3361 atcaagctat acatcatgaa ttagtcgcct cgagtttggt tacaaaaatt gctcgtgaga
     3421 ttaattcaga gtttaaggtg gggtgtatgg tattagctat gccagcttat ccaatgactc
     3481 caaatccaaa agatgtatgg gcgactcatg agtatgagaa tctaaattat ctattttcag
     3541 atgtgcatgt tagaggttat tatccgaatt atgcaaaaag atattttaag gaacatgaca
     3601 ttaacataga gtttgcagct gaagatgcag agttattaaa aaattatact gtagattttt
     3661 tatcctttag ctattacatg agtgtgactc aatctgctct tccaacacag tataattcag
     3721 gagaagggaa tattattggt ggcttagtaa atccttattt agagtcttct gagtggggat
     3781 ggcaaattga tccaattgga ctacgtataa ttttaaatag atattatgac cgttatcaaa
     3841 ttccattatt tatagtggaa aacggattag gtgctaaaga tcaactaata aaagatgaat
     3901 ttaataactt aacagtccaa gatgattata gaattcagta tatggaagaa catttattgc
     3961 aagtagctga agctctacaa gatggtgtgg aaattatggg ctatacatct tggggatgta
     4021 ttgactgcgt ttctatgtcc actgcacaac tttctaaaag gtacggtctc atttatgttg
     4081 atcgaaatga tgatggaaat ggcacattca atcgatataa gaaaatgtcc tttacttggt
     4141 ataaaggagt gattgaatca aatggagaat ccttattcaa atagtttgtt tattgatgat
     4201 tagatattat cacggttaag gcaacatctc attaaatatg aaataaagag gtttggaaga
     4261 catcaaattc taaacctctt tattttatag g
//
LOCUS       DAVHIZ010000088         4166 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.090, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000088 DAVHIZ010000000
VERSION     DAVHIZ010000088.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 4166)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4166)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4166
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.090"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..153)
                     /locus_tag="VVO18_001927"
     CDS             complement(<1..153)
                     /locus_tag="VVO18_001927"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5587014.1"
                     /translation="MAYSIDFRKKVLSYCERIGSITEASHVFQISRNTIYGWLKLKEK
                     TGELNHQ"
     gene            402..1847
                     /gene="cps4A"
                     /locus_tag="VVO18_001928"
     CDS             402..1847
                     /gene="cps4A"
                     /locus_tag="VVO18_001928"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000091082.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     Cps4A"
                     /protein_id="HEU5587015.1"
                     /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAF
                     RYLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNR
                     LNATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLT
                     VNQSSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAP
                     KTSKNQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADG
                     GNNQKDKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQ
                     EFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAIIQKLTST
                     EVLKNYSSILQGLQDSLQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSY
                     AMPDSNLYVMEIDDSSLAVVKAAIQDMMEGR"
     gene            1849..2580
                     /locus_tag="VVO18_001929"
     CDS             1849..2580
                     /locus_tag="VVO18_001929"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000565352.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-protein phosphatase CpsB"
                     /protein_id="HEU5587016.1"
                     /translation="MIDIHSHIVFDVDDGPKSREESKALLAESYRQGVRTIVSTSHRR
                     KGMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDS
                     RYALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYT
                     QINSYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIA
                     KKYGAKKAKELFVDNPRKIIMDQLI"
     gene            2589..3281
                     /gene="cpsC"
                     /locus_tag="VVO18_001930"
     CDS             2589..3281
                     /gene="cpsC"
                     /locus_tag="VVO18_001930"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000664160.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="capsular polysaccharide biosynthesis protein
                     CpsC"
                     /protein_id="HEU5587017.1"
                     /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVI
                     KPEFTSMTRIYVVNRDQGEKSGLTNQDLQAGSSLVKDYREIILSQDVLEEVVSDLKLD
                     LTPKDLANKIKVTVPVDTRIVSVSVSDRVPEEASRIANSLREVAAQKIISITRVSDVT
                     TLEEARPATSPSSPNIKRSTLIGFLAGVIGTSVIVLILELLDTRVKRPKDIEDTLQMT
                     LLGIVPNLNKLK"
     gene            3291..3974
                     /gene="cpsD"
                     /locus_tag="VVO18_001931"
     CDS             3291..3974
                     /gene="cpsD"
                     /locus_tag="VVO18_001931"
                     /EC_number="2.7.10.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001142521.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis tyrosine autokinase
                     CpsD"
                     /protein_id="HEU5587018.1"
                     /translation="MPTLEIAQKKLEFVKKAEEYYNALCTNIQLSGDKLKVISVTSVN
                     PGEGKTTTSVNIARSFARAGYKTLLIDGDIRNSVMSGFFKSREKITGLTEFLSGTADL
                     SHGLCDTNIENLFVVQSGTVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTAPIGIVI
                     DAAIITQKCDASILVTATGEVNKRDVQKAKQQLEQTGKLFLGVVFNKLDISVDKYGVY
                     GFYGNYGKK"
BASE COUNT         1325 a          662 c          860 g         1319 t
ORIGIN      
        1 ttggtggttt agctctcctg ttttctcttt tagctttaac cagccataaa tggtattacg
       61 tgagatttgg aaaacgtgtg atgcttctgt tatactacct attcgctcac aataagagag
      121 aactttttta cgaaaatcta ttgaatatgc cataagaaga ttataccaca ttgtgtacta
      181 tagtagattg aaactagagt agtacacctc tgcttctaaa acattgttag aaatcgattt
      241 gactgtcctg atcgatttgt catgttctta tttcatttta ctatattttt gtttcgcagg
      301 aagtctacta agatacttaa agatgcagat agtaaaaaaa tgtagacatt accgtaaaaa
      361 agtgatataa tcgtatgatg ttcaaggtat aggtgttaat catgagtaga cgttttaaaa
      421 aatcacgttc acagaaagtg aagcgaagtg ttaatatcgt tttgctgact atttatttat
      481 tgttagtttg ttttttattg ttcttaatct ttaagtacaa tatccttgct tttagatatc
      541 ttaacctagt ggtaactgcg ttagtcctac tagttgcctt ggtagggcta ctcttgatta
      601 tctataaaaa agctgaaaag tttactattt ttctgttggt gttctctatc cttgtcagct
      661 ctgtgtcgct ctttgcagta cagcagtttg ttggactgac caatcgttta aatgcgactt
      721 ctaattactc agaatattca atcagtgtcg ctgttttagc agatagtgat atcgaaaatg
      781 ttacgcaact gacgagtgtg acagcaccga ctgggactga taatgaaaat attcaaaaac
      841 tactagctga tattaagtca agtcagaata ccgatttgac ggtcaaccag agttcgtctt
      901 acttggcagc ttacaagagt ttgattgcag gggagactaa ggccattgtc ctaaatagtg
      961 tctttgaaaa catcatcgag tcagagtatc cagactacgc atcgaagata aaaaagattt
     1021 ataccaaggg attcactaaa aaagtagaag ctcctaagac gtctaagaat cagtctttca
     1081 atatctatgt tagtggaatt gacacctatg gtcctattag ttcggtgtcg cgatcagatg
     1141 tcaatatcct gatgactgtc aatcgagata ccaagaaaat cctcttgacc acaacgccac
     1201 gtgatgccta tgtaccaatc gcagatggtg gaaataatca aaaggataaa ttaacccatg
     1261 caggcattta tggagttgat tcgtccattc acaccttaga aaatctctat ggagtggata
     1321 tcaattacta tgtgcgattg aacttcactt ctttcttgaa aatgattgac ttattgggag
     1381 gggtagatgt tcataatgat caagagtttt cagctctaca tgggaagttc catttcccag
     1441 tagggaatgt ccatctagac tctgagcagg ctctaggttt tgtacgtgaa cgctactcac
     1501 tagccgatgg agaccgtgac cgtggtcgca accaacaaaa ggtcattgta gcaattattc
     1561 agaagttaac ttctacagag gttttgaaaa actatagtag tattcttcaa ggattgcagg
     1621 attctcttca aacaaatatg ccgattgaga ctatgataga tttagtgaat actcagttgg
     1681 aaagtggggg gaattataaa gtaaattctc aagatttaaa agggacaggt cggatggatc
     1741 ttccttctta tgcaatgcca gacagtaacc tctatgtgat ggaaatagat gatagtagtt
     1801 tagctgtagt taaagcagct atacaggata tgatggaggg tagatgaaat gatagacatc
     1861 cattcgcata tcgtttttga tgtagatgac ggtcccaagt caagagagga aagcaaggct
     1921 ctcttggcag aatcctacag gcagggggtg cgaaccattg tctctacctc tcaccgtcgc
     1981 aagggcatgt ttgaaactcc ggaagagaag atagcagaaa actttcttca ggttcgggaa
     2041 attgcaaaag aagtggcaga tgatttagtc attgcttatg gcgcagagat atactatact
     2101 ctggatgctc tagaaaagct agaaaaaaaa gaaattccta cccttaatga tagtcgttat
     2161 gccttgattg agtttagcat gcatacttcc tatcgtcaga ttcatacggg attgagcaat
     2221 attttgatgt tgggaatcac gccagtaatt gctcatattg aacgttatga tgctttagag
     2281 aataacgaaa aacgtgttcg tgaactgatt gatatggggt gctatactca gataaatagt
     2341 tatcatgttt cgaaacctaa gttctttggt gaaaaatata aattcatgaa aaagagagct
     2401 cggtattttt tggaacgtga tttagttcat gtagttgcaa gtgacatgca caatttagac
     2461 agtagacctc catatatgca acaggcatat gatatcattg ctaagaaata tggagcgaaa
     2521 aaagcaaaag aactttttgt agataatccc agaaaaatta taatggatca attaatttag
     2581 gagaaaatat gaaggaacaa aacactttgg aaatcgatgt attgcaacta ttcagagctt
     2641 tatggaaaag aaagttggtc attttattag tggcaattat aacttcttca gttgcttttg
     2701 cctacagtac ttttgttatc aaacctgagt ttactagtat gactcggatt tatgtagtta
     2761 accgtgatca gggagagaag tctggtttaa ccaatcaaga cttgcaggca ggatcatcct
     2821 tggttaaaga ctatcgtgaa attatcctat cgcaggatgt tttggaggaa gttgtttctg
     2881 atttgaaact agatttgacg ccaaaagatt tggctaataa aattaaagta acagtaccag
     2941 ttgatacccg tattgtctct gtttcagtta gtgatcgagt tcctgaagag gcaagccgta
     3001 tcgctaactc tttgagagaa gtagctgctc aaaaaattat cagtattact cgtgtttctg
     3061 atgtgacaac actggaggag gcaagaccgg cgacatcacc gtcttcgcca aatattaaac
     3121 gcagtacact aattggtttt ttggcaggag tgattggaac tagtgttata gttcttattc
     3181 ttgaactttt ggacactcgt gtgaaacgtc cgaaagatat cgaagataca ctgcagatga
     3241 cacttttggg aattgtacca aacttgaata agttgaaata ggagagagga atgccgacat
     3301 tagaaatagc acaaaaaaaa ctggagttcg ttaagaaggc agaagaatat tacaatgcct
     3361 tgtgtacaaa tatacagttg agcggagata aactaaaagt aatttccgtt acttctgtta
     3421 accctgggga aggaaaaaca actacttccg taaatatagc aaggtcgttt gcgcgtgcag
     3481 gctataaaac tcttttgatc gatggcgata ttcgaaattc agttatgtca ggatttttta
     3541 aatctcgtga aaaaattaca gggctaacgg aatttttatc tgggacagct gatttatctc
     3601 acggtttatg tgatacaaat attgaaaatt tatttgtagt tcaatcgggc actgtatcac
     3661 caaaccctac agccttgtta caaagtaaaa attttaatga tatgattgaa acattgcgta
     3721 aatattttga ttatataatt gttgatacag cacctattgg aattgttatt gatgcggcaa
     3781 ttatcactca aaagtgtgat gcgtccatct tggtaacagc aacaggtgag gtgaataaac
     3841 gtgatgtcca aaaagcgaaa caacaattag aacaaacagg gaaactgttc ctaggagttg
     3901 tttttaataa attagatatc tcggttgata agtatggagt ttacggtttc tatggaaatt
     3961 atggtaaaaa ataatttagg aaagattcta tggatgaaaa aggattgaaa atttttttgg
     4021 cagtattaca gagtattatt gtcattttat tggtttattt tcttagcttt gttagagaga
     4081 cagaacttga acgttcttcg atggttatac tataccttct ccactttttt gtattctatt
     4141 ttagttccta tggtaacaat tttttt
//
LOCUS       DAVHIZ010000089         3894 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.091, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000089 DAVHIZ010000000
VERSION     DAVHIZ010000089.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3894)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3894)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3894
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.091"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..889)
                     /locus_tag="VVO18_001932"
     CDS             complement(<1..889)
                     /locus_tag="VVO18_001932"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001101767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcription antiterminator"
                     /protein_id="HEU5587019.1"
                     /translation="MNVLNIKEKDILQFLIKNKERFVTSKELAEYLSCSDRTVRNVLK
                     LIEKTMIIQGVRLISKQGQGYQIFFENQGAYQEFRQTYELEEDYTKTAVSKGDDRLVF
                     ILNKLLFEQVPVLFDDLADELYVSRSTLSHDFRKIRVMLSEYNLSIESRANKGVYVSG
                     EERDKRRFIINYFLENQFFKTIHCYVKFNFFDQTVPLEEFARIVLDECQEANLKLSDF
                     VLQNLVVHIALSVIRLKSGFEIKNIDCQMTDDAIERKVAQRILSKVREVTNQEFPVQE
                     IDYITLHLLAKSQQCQKNQK"
     gene            complement(1007..1321)
                     /locus_tag="VVO18_001933"
     CDS             complement(1007..1321)
                     /locus_tag="VVO18_001933"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003037418.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIB"
                     /protein_id="HEU5587020.1"
                     /translation="MAKALIICAAGMSSSLMAQKTTEFLKGKGKDIVVDAISATEGGK
                     AIAAAAFDLYLVSPQTKMYFKQFEEAGSKAGKPVVQIPPQAYIPIPMGIEKMANLILE
                     NI"
     gene            complement(1451..1690)
                     /locus_tag="VVO18_001934"
     CDS             complement(1451..1690)
                     /locus_tag="VVO18_001934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000580385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SemiSWEET family sugar transporter"
                     /protein_id="HEU5587021.1"
                     /translation="MIGSIAAILTTFAFLPQVFRVVKTKDTGSIALGMYVMQVIGIAL
                     WLAHGIRIGDLPLILANSVSFLLSGIILFYKLKYK"
     gene            complement(1742..3178)
                     /locus_tag="VVO18_001935"
     CDS             complement(1742..3178)
                     /locus_tag="VVO18_001935"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861533.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="HEU5587022.1"
                     /translation="MTTFKDGFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVA
                     REITSGVLEGKYYPNHEAIDFYHRYKEDIALFAEMGFKCFRTSLAWTRIFPKGDELEP
                     NEEGLQFYDNLFDECLKNGIEPVITLSHFEMPYHLVTEYGGWKNRKLIDFFARFAEVV
                     FKRYKDKVKYWMTFNEINNQANYQEDFAPFTNSGIVYEEGDNREAIMYQAAHYELVAS
                     ARAVKIGHEINPDFQIGCMIAMCPIYPATCNPKDILMAMKAMQKRYYFADVHVLGKYP
                     EHIFKYWERKGISVDFTAQDKEDLLGGTVDYIGFSYYMSFAIDFHRENNPYFDYLETE
                     DLVKNNYVKASEWEWQIDPEGLRYALNWFTDHYHLPLFIVENGFGAIDQVAADGMIHD
                     DYRIEYLGAHIREMKKAVVEDGVDLMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDN
                     GKGSYNRSPKKSFGWYKEVISSNGESVE"
     gene            complement(3368..3706)
                     /locus_tag="VVO18_001936"
     CDS             complement(3368..3706)
                     /locus_tag="VVO18_001936"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000176371.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="HEU5587023.1"
                     /translation="MTLTIHVYYKDDGDSAIKFAREMLDSGLVEEIRNQKGNLKYEYF
                     LPIEKEGTILLIDQWINQETLDKHYQSKTMQKILDLRKKYHLQMQVERYIEDDSGMPE
                     SDKSFIDTGN"
BASE COUNT         1288 a          786 c          482 g         1338 t
ORIGIN      
        1 tcttctgatt tttttgacat tgttgactct tagctaacaa atgcaaagta atgtagtcta
       61 tttcctgaac tggaaattcc tgatttgtta cttctcttac tttagaaaga attctttggg
      121 caacctttct ctctattgca tcatcagtca tctgacagtc tatatttttt atttcaaatc
      181 cggattttaa acgaatcaca gacaatgcta tgtgaactac taaattctgt agtacaaaat
      241 cagatagttt taggttggcc tcttggcatt catccaaaac aattctagca aattcttcta
      301 atggaacagt ttgatcaaaa aagttaaatt ttacatagca atgtattgtt ttaaaaaatt
      361 gattctctag gaaataattt atgataaaac gtcgtttatc acgttcctcg cctgagacat
      421 aaactccttt attcgcccta ctctcaatgg acaaattata ctctgataac atcactcgta
      481 tctttctgaa atcatgagat aatgttgaac gactaacgta aagttcatca gctaaatcat
      541 caaaaagaac tggaacttgc tcaaataata atttatttaa gataaatact aaacgatcat
      601 caccttttga aaccgcagtt ttcgtatagt cttcttccag ttcataagtt tgtctaaact
      661 cctggtaagc gccttgattc tcaaaaaata tttgataccc ttgaccttgt tttgaaatca
      721 accggactcc ttgaataatc attgtcttct caattaattt cagtacatta cggacagttc
      781 tatctgaaca ggataaatat tctgccagtt ctttgcttgt aacaaaacgt tccttatttt
      841 ttattaaaaa ttgaaggata tctttctctt taatgtttaa cacattcatt ccctcctaaa
      901 acgtatgttt tcatatattg aagcatatta tacacttaaa tcaatttata tcaaactcaa
      961 aacaatttat cttaacctaa atatttattg acatttcatg tgttcatcaa atattctcaa
     1021 gaatcaaatt agccattttt tcaattccca ttggaatagg aatatatgct tgaggaggta
     1081 tttgtacaac tggttttcct gctttagaac cagcctcttc aaattgctta aagtacattt
     1141 ttgtttgagg gctgacaaga tacaaatcaa aagctgctgc tgcgatagct ttccctcctt
     1201 cagtagcact aatagcatca actacaatat ctttcccttt tccttttaga aactctgttg
     1261 ttttctgtgc cataagtgat gaagacattc ctgctgcaca aataattaaa gcttttgcca
     1321 taatattttc tccttttctt aaatccaatc aaagctgtgc taagttggct tatttgttat
     1381 ctatttttat tataaaataa agcgtttcca atgataattc cctcattttc ctaaatgata
     1441 tggaaaaaaa ttatttatac ttcaatttat aaaataaaat tattcctgag agtagaaatg
     1501 aaacactatt tgctaaaatc aaaggcaagt ctcctatacg aataccatga gcaagccaca
     1561 atgcaatacc aataacttgc ataacataca tacctagagc aatagatcct gtgtcctttg
     1621 tcttaactac acgaaaaact tgtggtaaaa atgcaaatgt tgttaaaatt gctgcaatac
     1681 ttccaatcat atgtcacctc aatatgctaa acaaactgag aataatctca gtttgtttat
     1741 actattctac tgattcaccg ttagatgaaa taacttcctt ataccagcca aaagattttt
     1801 tcggggaacg attataactt cccttcccat tatcatcttt atctacataa ataaagccat
     1861 aacgtttccg catttcaccg gtaccagctg aaaccaaatc aatacatccc catggagtat
     1921 aacccattaa atcaacacca tcttcaacta cagccttttt catttcacga atatgggcac
     1981 ctagatattc aattctataa tcatcatgta tcataccatc tgctgcaact tgatctatag
     2041 ctccaaaacc attttcaaca ataaagagtg gtaagtgata gtggtctgta aaccaattta
     2101 acgcataacg taaaccttct ggatcaattt gccactccca ttcagaagcc ttaacataat
     2161 tatttttcac taaatcttct gtttcaagat aatcaaaata aggattattt tcacgatgaa
     2221 agtcgatagc aaaggacata tagtaactga aaccaatgta atctacagtc ccaccaagta
     2281 aatcttcttt atcctgggca gtaaaatcaa ctgaaatacc ttttcgttcc caatacttga
     2341 aaatatgctc aggatattta cctaaaacat gcacatcagc aaaataataa cgcttctgca
     2401 tagctttcat tgccattaag atatccttag gattgcaagt agctggataa attggacaca
     2461 tcgcaatcat acaacctatt tgaaaatctg gattaatctc atgaccaatt tttacagctc
     2521 gtgcagaagc aactaattcg taatgtgctg cttgatacat aattgcttct ctattatcac
     2581 cttcctcata tacaatacct gagttagtaa atggtgcaaa atcttcctga taattcgctt
     2641 gattattgat ttcattgaaa gtcatccaat atttaacctt atctttgtaa cgtttaaata
     2701 cgacttctgc aaaacgagca aagaaatcaa tcaatttcct atttttccaa ccaccatatt
     2761 cggtcactaa gtgataaggc atttcaaaat gagatagagt gatgacaggt tcaataccat
     2821 tctttaagca ttcatcaaaa agattatcat aaaactgtaa tccttcttca ttcggctcta
     2881 actcatcacc ttttggaaag atacgtgtcc atgcaagaga ggtacggaag cacttgaatc
     2941 ccatttcagc aaaaagtgct atgtcttctt tataacgatg ataaaaatct atcgcctcat
     3001 gatttggata atatttaccc tctaaaactc ccgaagtaat ttcacgagct actccatgac
     3061 gaccagcagt cataacatca gcaacactaa ttcccttgcc accttcttgc catccacctt
     3121 caagttgatg agcagcaaca gcaccacccc ataaaaatcc atctttaaaa gtagtcatct
     3181 tttttcctcc tgactttgat actcttatta taaacctcaa accaaaagat gaaaacgcat
     3241 tctttttcct tattgttaag gaaagaagta atttttaatg gaaatagaac aatatcttct
     3301 tgtattctcg taatgatatc tttacgattt tcaatacttt caaactacaa aaactctcac
     3361 aataattcta attccctgtg tctataaacg acttatcgct ttctggcatc ccagaatcat
     3421 cttctatata acgttcaact tgcatctgca agtgatattt ttttcttaaa tctaagattt
     3481 tctgcattgt ctttgattga taatgtttat ctaaagtttc ttgatttatc cactgatcaa
     3541 taaggagaat agttccctct ttttcaattg gtaaaaaata ttcgtatttc aagttacctt
     3601 tttgatttct aatttcttca acaaggccac tatcaagcat ttctcttgca aactttattg
     3661 cactatctcc atcatcttta taatatacat gaatagtcaa tgtcatctta tatcctccaa
     3721 aatcatcctt caattttaaa aaaacaagtt tagatgagga tctaaacttg ttttttatga
     3781 actaattatc taacgtttcg ccattacttt caatcacttc tttataccaa taaaatgatt
     3841 ttttcttata gcgatttata gtcaattgaa acaagaacaa gacaaaagag cctc
//
LOCUS       DAVHIZ010000090         3771 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.092, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000090 DAVHIZ010000000
VERSION     DAVHIZ010000090.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3771)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.092"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            104..1285
                     /locus_tag="VVO18_001937"
     CDS             104..1285
                     /locus_tag="VVO18_001937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681590.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEU5587024.1"
                     /translation="MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNS
                     NNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSE
                     GSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
                     EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAI
                     STKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINI
                     IEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHL
                     EKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLE
                     S"
     gene            1343..2101
                     /locus_tag="VVO18_001938"
     CDS             1343..2101
                     /locus_tag="VVO18_001938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="HEU5587025.1"
                     /translation="MEKFEMISITDIQKNPYQPRKEFDREKLDELAQSIKENGVIQPI
                     IVRQSPVIGYEILAGERRYRASLLAGLRSIPAVVKQISDQEMMVQSIIENLQRENLNP
                     IEEARAYESLVEKGFTHAEIADKMGKSRPYISNSIRLLSLPEQILSEVENGKLSQAHA
                     RSLVGLNKEQQDYFFQRIIEEDISVRKLEALLTEKKQKKQQKTNHFIQNEEKQLRKLL
                     GLDVEIKLSKKDSGKIIISFSNQEEYSRIINSLK"
     gene            2314..3675
                     /gene="dnaA"
                     /locus_tag="VVO18_001939"
     CDS             2314..3675
                     /gene="dnaA"
                     /locus_tag="VVO18_001939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004255267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromosomal replication initiator protein DnaA"
                     /protein_id="HEU5587026.1"
                     /translation="MKEKQFWNRILEFAQERLTRSMYDFYAIQAELIKVEENVATIFL
                     PRSEMEMVWEKQLKDIIVVAGFEIYDAEITPHYIFTKPQDTTSSQVEEATNLTLYDYS
                     PKLVSIPYSDTGLKEKYTFDNFIQGDGNVWAVSAALAVSEDLALTYNPLFIYGGPGLG
                     KTHLLNAIGNEILKNIPNARVKYIPAESFINDFLDHLRLGEMEKFKKTYRSLDLLLID
                     DIQSLSGKKVATQEEFFNTFNALHDKQKQIVLTSDRSPKHLEGLEERLVTRFSWGLTQ
                     TITPPDFETRIAILQSKTEHLGYNFQSDTLEYLAGQFDSNVRDLEGAINDITLIARVK
                     KIKDITIDIAAEAIRARKQDVSQMLVIPIDKIQTEVGNFYGVSIKEMKGSRRLQNIVL
                     ARQVAMYLSRELTDNSLPKIGKEFGGKDHTTVIHAHAKIKSLIDQDDNLRLEIESIKK
                     KIK"
BASE COUNT         1337 a          651 c          678 g         1105 t
ORIGIN      
        1 gtttcaaaag agttatccac agtttgtgta aaacttttgt gtttaagtta taattaagct
       61 agtcagttta tactttcagt aattcaaaca tatggaggca aatatgaaac atctaaaaac
      121 attttacaaa aaatggtttc aattattagt cgttatcgtc attagctttt ttagtggagc
      181 cttgggtagt ttttcaataa ctcaactaac tcaaaaaagt agtgtaaaca actctaacaa
      241 caatagtact attacacaaa ctgcctataa gaacgaaaat tcaacaacac aggctgttaa
      301 caaagtaaaa gatgctgttg tttctgttat tacttattcg gcaaacagac aaaatagcgt
      361 atttggcaat gatgatactg acacagattc tcagcgaatc tctagtgaag gatctggagt
      421 tatttataaa aagaatgata aagaagctta catcgtcacc aacaatcacg ttataaatgg
      481 cgccagcaaa gtagatatta gattgtcaga tgggactaaa gtacctggag aaattgtcgg
      541 agctgacact ttctctgata ttgctgtcgt caaaatctct tcagaaaaag tgacaacagt
      601 agctgagttt ggtgattcta gtaagttaac tgtaggagaa actgctattg ccatcggtag
      661 cccgttaggt tctgaatatg caaatactgt cactcaaggt atcgtatcca gtctcaatag
      721 aaatgtatcc ttaagatcgg aagatggaca agctatttct acaaaagcca tccaaactga
      781 tactgctatt aacccaggta actctggcgg cccactgatc aatattcaag ggcaggttat
      841 cggaattacc tcaagtaaaa ttgctacaaa tggaggaaca tctgtagaag gtcttggttt
      901 cgcaattcct gcaaatgatg ctatcaatat tattgaacag ttagaaaaaa acggaaaagt
      961 gacgcgtcca gctttgggaa tccagatggt taatttatct aatgtgagta caagcgacat
     1021 cagaagactc aatattccaa gtaatgttac atctggtgta gttgttcgtt cggtacaaag
     1081 taatatgcct gccaatggtc accttgaaaa atacgatgta attacaaaag tagatgacaa
     1141 agagattgct tcatcaacag acttacaaag tgctctttac aaccattcta tcggagacac
     1201 cattaagata acctactatc gtaacgggaa agaagaaact acctctatca aacttaacaa
     1261 gagttcaggt gatttagaat cttgattgac atctatgtaa agaaagcttt acataagaga
     1321 aaagatgtgt tagtgtagaa tcatggaaaa atttgaaatg atttctatca cagatataca
     1381 aaaaaatccc tatcaacccc gaaaagaatt tgatagagaa aaactagatg aactagcaca
     1441 gtctatcaaa gaaaatgggg tcattcaacc gattattgtt cgtcaatctc ctgttattgg
     1501 ttatgaaatc cttgcaggag agagacgcta tcgggcttca cttttagctg gtctacggtc
     1561 tatcccagct gttgttaaac agatttcaga ccaagagatg atggtccagt ccattattga
     1621 aaatttacag agagaaaatt taaacccaat agaagaagca cgcgcctatg aatctctcgt
     1681 agagaaagga ttcacccatg ctgaaattgc agataagatg ggcaagtctc gtccatatat
     1741 cagcaactcc attcgtttac tttccttgcc agaacagatt ctttcagaag tagaaaatgg
     1801 caaactatca caagcccatg cgcgttccct agttgggtta aataaggaac aacaagacta
     1861 tttctttcaa cggattatag aagaagatat ttctgtaagg aaattagaag ctcttctgac
     1921 agagaaaaaa caaaagaaac agcaaaaaac taatcatttc atacaaaatg aagaaaaaca
     1981 gttaagaaaa ctactcggat tagatgtaga aattaaacta tctaaaaaag acagtggaaa
     2041 aatcattatt tctttttcaa atcaagaaga atatagtaga attatcaaca gcctgaaata
     2101 aggctgttct tttatttttt tatctcacaa ggttatccac tatgtttttc gataaaaagc
     2161 ttaataaatc aataatttct tcttttatcc ccaacctgtg gataaagttt ggtaacattg
     2221 tggattattt ttcacagctt gtggaaaatt cttgctatct atggtaaaat atctctagta
     2281 ttaaactttt aaatagtaaa ggaggagaaa ggattgaaag aaaaacaatt ttggaatcgt
     2341 atattagaat ttgcacaaga aagactgact cgatccatgt atgatttcta tgctattcaa
     2401 gctgaactca tcaaggtaga ggaaaatgtt gccactatat ttctacctcg ctctgaaatg
     2461 gaaatggtct gggaaaaaca actaaaagat attattgtag tagctggttt tgaaatttat
     2521 gacgctgaaa taactcccca ctatattttc accaaacctc aagatacgac tagctcacaa
     2581 gttgaagaag ctacaaattt aactctttat gactatagtc caaagttagt atctattcct
     2641 tattcagata cgggattaaa agaaaagtat acctttgata actttattca aggggatgga
     2701 aatgtttggg ctgtatcagc cgctttagct gtctctgaag atttggctct gacctataac
     2761 cctcttttta tctatggagg accaggcctt ggtaagactc acttattaaa cgctattgga
     2821 aatgaaattc taaaaaatat tcctaatgcg cgtgttaaat atatccctgc cgaaagcttt
     2881 attaatgact ttcttgatca cctaagactt ggggaaatgg aaaagtttaa aaagacctat
     2941 cgtagtcttg atcttttgtt aatcgatgat atacagtcac tcagcggaaa aaaagtcgca
     3001 actcaggaag aatttttcaa tacctttaac gcccttcatg acaagcaaaa acagattgtc
     3061 ctaacgagtg atcgtagtcc aaaacatcta gaagggctcg aggagaggct tgtcacgcgt
     3121 tttagttggg gattgacaca aactatcaca ccccctgact ttgaaacacg tattgccatt
     3181 ttacaaagta agacggaaca tttaggctac aatttccaaa gtgatactct agaataccta
     3241 gctgggcaat ttgattcaaa tgttcgagat cttgagggag ccatcaacga catcacttta
     3301 attgccagag taaaaaaaat caaggatatc actattgata ttgctgcaga agccattaga
     3361 gcccgcaaac aagatgttag ccaaatgctc gtcatcccaa ttgataaaat ccaaactgaa
     3421 gttggtaact tttatggtgt tagtatcaaa gaaatgaagg gaagtagacg ccttcaaaat
     3481 attgttttgg cccgtcaagt agccatgtat ttatctagag aactaacaga taatagtctt
     3541 ccaaaaattg ggaaggaatt tgggggaaaa gatcatacca cagtcattca tgcccatgcc
     3601 aaaataaaat ctttgattga tcaagacgat aatttacgtt tagaaattga atcaatcaaa
     3661 aagaaaatca aataatttgt ggataacttt tagtttttta tcttttttat ccacattttt
     3721 taaacaagct aaaaaacttg atatgacttg tttaaaggct gttttccaca g
//
LOCUS       DAVHIZ010000091         3724 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.093, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000091 DAVHIZ010000000
VERSION     DAVHIZ010000091.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3724)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.093"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            68..295
                     /locus_tag="VVO18_001940"
     CDS             68..295
                     /locus_tag="VVO18_001940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000576349.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587027.1"
                     /translation="MIFKAFKTKKQRKRQVELLLTVFFDSFLIDLFLHLFGIVPFKLD
                     KILIVSLIIFPIISTSIYAYEKLFEKVFDKD"
     gene            583..3528
                     /gene="nanA"
                     /locus_tag="VVO18_001941"
     CDS             583..3528
                     /gene="nanA"
                     /locus_tag="VVO18_001941"
                     /EC_number="3.2.1.18"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014632427.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LPXTG-anchored neuraminidase NanA"
                     /protein_id="HEU5587028.1"
                     /translation="MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASE
                     QPLANETQLSGGSSTLTDTEKSQPSEEGENITLPAEHVESVSETELSGNKQEQERKDK
                     QEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFK
                     PDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKP
                     GQWNSVTFTVEKPTAELPNGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRA
                     NNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESG
                     RNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWG
                     DRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQK
                     EEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGD
                     LYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKF
                     LGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVN
                     DNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTW
                     EKDIKRYPQVKDVYVQMSAIHTMHNGKEYIILSNAGGPNRENGMVHLARVEENGELTW
                     LKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLIFPT
                     EAKVKRTREMGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFA
                     VDKEDIGQEIIGIAKGSIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTE
                     PAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGL
                     FTLGKKREQ"
BASE COUNT         1267 a          624 c          851 g          982 t
ORIGIN      
        1 aaatagtagt agctatgcga aataacagat agagagaagg gattgaagct tagaaaaggg
       61 gaataatatg atatttaagg cattcaagac aaaaaagcag agaaaaagac aagttgaact
      121 acttttgaca gtttttttcg acagttttct gattgattta tttcttcact tatttgggat
      181 tgtccccttt aagctggata agattctgat tgtgagcttg attatatttc ccattatttc
      241 tacaagtatt tatgcttatg aaaagctatt tgaaaaagtg ttcgataagg attgagcagg
      301 aagtatggtg taaatagcat aggctgatgt ccatcatttg cttataaaga gatattttag
      361 tttaattgca gcggtgtcct ggtagataaa ctagattggc aggagtctga ttggagaaag
      421 gagaggggaa atttggcacc aatttgagat agtttgttta gttcattttt gtcatttaaa
      481 tgaactgtag taaaagaaag ttaataaaag acaaactaag tgcattttct ggagtaaatg
      541 tcttatttca gaaatcggga tatagatata gagaggatca gtatgaatcg gagtgttcaa
      601 gaacgtaagt gtcgttatag cattaggaaa ctatcggtag gagcggtttc tatgattgta
      661 ggagcagtgg tatttggaac gtctcctgtt ttagctcaag aaggggcaag tgagcaacct
      721 ctggcaaatg aaactcaact ttcgggggga agctcaaccc taactgatac agaaaagagc
      781 cagccttctg aggaaggaga aaatataact cttcctgcag agcatgtaga gtctgtttca
      841 gagactgaac tttctggcaa taagcaagaa caagaaagga aagataagca agaagaaaaa
      901 attccaagag attactatgc acgagatttg gaaaatgtcg aaacagtgat agaaaaagaa
      961 gatgttgaaa ccaatgcttc aaatggtcag agagttgatt tatcaagtga actagataaa
     1021 ctaaagaaac ttgaaaacgc aacagttcac atggagttta agccagatgc caaggcccca
     1081 gcattctata atctcttttc tgtgtcaagt gctactaaaa aagatgagta cttcactatg
     1141 gcagtttaca ataatactgc tactctagag gggcgtggtt cggatgggaa acagttttac
     1201 aataattaca acgatgcacc cttaaaagtt aaaccaggtc agtggaattc tgtgactttc
     1261 acagttgaaa aaccgacagc agaattgcca aatggtcgag ttcgcctgta tgttaatggt
     1321 gttttatctc gaacaagtct gaaatctggc aatttcatta aagatatgcc agatgtaacg
     1381 catgtgcaaa tcggagcaac caagcgtgcc aacaatacgg tttgggggtc aaatctacag
     1441 attcggaatc tcactgtgta taatcgtgct ttaacaccag aagaggtaca aaaacgtagt
     1501 caacttttta aacgctcaga tttagaaaaa aaactacctg aaggagcggc tttaacagag
     1561 aaaacggaca tattcgaaag cgggcgtaac ggtaaaccaa ataaagatgg aatcaagagt
     1621 tatcgtattc cagcacttct caagacagat aaaggaactt tgatcgcagg tgcagatgaa
     1681 cgccgtctcc attcgagtga ctggggtgat atcggtatgg tcatcagacg tagtgaagat
     1741 aatggtaaaa cttggggtga ccgagtaacc attaccaact tacgtgacaa tccaaaagct
     1801 tctgacccat cgatcggttc accagtgaat atcgatatgg tgttggttca agatcctgaa
     1861 accaaacgaa tcttttctat ctatgacatg ttcccagaag ggaagggaat ctttggaatg
     1921 tcttcacaaa aagaagaagc ctacaaaaaa atcgatggaa aaacctatca aatcctctat
     1981 cgtgaaggag aaaagggagc ttataccatt cgagaaaatg gtactgtcta tacaccagat
     2041 ggtaaggcga cagactatcg cgttgttgta gatcctgtta aaccagccta tagcgacaag
     2101 ggtgatctat acaagggtaa ccaattacta ggcaatatct acttcacaac aaacaaaact
     2161 tctccattta gaattgccaa ggatagctat ctatggatgt cctacagtga tgacgacggg
     2221 aagacatggt cagcgcctca agatattact ccgatggtca aagccgattg gatgaaattc
     2281 ttgggtgtag gtcctggaac aggaattgta cttcggaatg ggcctcacaa gggacggatt
     2341 ttgataccgg tttatacgac taataatgta tctcacttaa atggctcgca atcttctcgt
     2401 gtcatctatt cagatgatca tggaaaaact tggcatgctg gagaagcggt caacgataac
     2461 cgtcaggtag acggtcaaaa gatccactct tctacgatga acaatagacg tgcgcaaaat
     2521 acagaatcaa cggtggtaca actaaacaat ggagatgtta aactctttat gcgtggtttg
     2581 actggagatc ttcaggttgc tacaagtaaa gacggaggag tgacttggga gaaggatatc
     2641 aaacgttatc cacaggttaa agatgtctat gttcaaatgt ctgctatcca tacgatgcat
     2701 aatggaaaag aatacattat cctcagcaat gcaggtggac cgaatcgtga aaatgggatg
     2761 gtccacttgg cacgtgtcga agaaaatggt gagttgactt ggctcaaaca caatccaatt
     2821 caaaaaggag agtttgccta taattcgctc caagaattag gaaatgggga gtatggcatc
     2881 ttgtatgaac atactgaaaa aggacaaaat gcctataccc tatcatttag aaaatttaat
     2941 tgggaatttt tgagcaaaga tctgattttt cctaccgaag cgaaagtgaa gcgaactaga
     3001 gagatgggca aaggagagat gggcaaagga gttattggct tggagttcga ctcagaagta
     3061 ttggtcaaca aggctccaac ccttcaattg gcaaatggta aaacagcgac tttcctaacc
     3121 cagtatgata gcaagacctt gttgtttgca gtagataagg aagatatcgg acaggaaatt
     3181 attggtatag ctaaaggaag catcgaaagt atgcataatc ttcctgtaaa tctagcaggt
     3241 gccagagttc ctggcggagt aaatggtagc aaagcagcgg tgcatgaagt tccagaattt
     3301 acagggggag ttaatggtac agagccagct gttcatgaaa tcgcagagta taagggatct
     3361 gattcgcttg taactcttac tacaaaagaa gattatactt acaaagctcc tcttgctcag
     3421 caggcacttc ctgaaacagg aaacaaggag agtgacctcc tagcttcact aggactaaca
     3481 gctttcttcc ttggtctgtt tacgctaggg aaaaagagag aacaataaga gaagaattct
     3541 aaacatttga ttttgtaaaa atagaaggag atagcaggtt ttcaagcctg ctatcttttt
     3601 ttgatgacat tcaggctgat acgaaatcat aagaggtctg aaactacttt cagagtagtc
     3661 tgttctataa aatatagtag attgaaataa gatgtgaaca actctatcag gaaagtcaaa
     3721 ttaa
//
LOCUS       DAVHIZ010000092         3706 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.094, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000092 DAVHIZ010000000
VERSION     DAVHIZ010000092.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3706)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3706)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3706
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.094"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..384
                     /locus_tag="VVO18_001942"
     rRNA            <1..384
                     /locus_tag="VVO18_001942"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
     gene            436..508
                     /locus_tag="VVO18_001943"
     tRNA            436..508
                     /locus_tag="VVO18_001943"
                     /product="tRNA-Ala"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:469..471,aa:Ala,seq:tgc)
     gene            633..3534
                     /locus_tag="VVO18_001944"
     rRNA            633..3534
                     /locus_tag="VVO18_001944"
                     /product="23S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF02541"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF02541"
     gene            3611..>3706
                     /gene="rrf"
                     /locus_tag="VVO18_001945"
     rRNA            3611..>3706
                     /gene="rrf"
                     /locus_tag="VVO18_001945"
                     /product="5S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00001"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00001"
BASE COUNT         1052 a          758 c         1081 g          815 t
ORIGIN      
        1 tgccggtaat aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc
       61 tgggctacac acgtgctaca atggctggta caacgagtcg caagccggtg acggcaagct
      121 aatctcttaa agccagtctc agttcggatt gtaggctgca actcgcctac atgaagtcgg
      181 aatcgctagt aatcgcggat cagcacgccg cggtgaatac gttcccgggc cttgtacaca
      241 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cgtaaggagc
      301 cagccgccta aggtgggata gatgattggg gtgaagtcgt aacaaggtag ccgtatcgga
      361 aggtgcggct ggatcacctc ctttctaagg ataaggaact gcgcattggt cttgtttagt
      421 cttgagaggt cttgtggggc cttagctcag ctgggagagc gcctgctttg cacgcaggag
      481 gtcagcggtt cgatcccgct aggctccatt ggtgagagat caccaagtaa tgcacattga
      541 aaattgaata tctatatcaa atagtaacaa gaaaataaac cgaaaacgct gtagtattaa
      601 taagagttta tgactgaaag gtcagaaaat aaggttaagt taataagggc gcacggtgga
      661 tgccttggca ctaggagccg acgaaggacg tgacaaacga cgatatgcct tgggtagctg
      721 taagtaagcg atgatccagg gatttccgaa tgggggaacc caacaggtaa tacctgttac
      781 ccacatctgt taaggatgtg aggaggaaga cgcagtgaac tgaaacatct aagtagctgc
      841 aggaagagaa agcaaaagcg attgccttag tagcggcgag cgaaacggca gaagggcaaa
      901 ccgaagagtt tactcttcgg ggttgtagga ctgcaatgtg gactcaaaga ttatagaaga
      961 atgatttggg aagatcagcc aaagagagta atagcctcgt atttaaaata gtctttgtac
     1021 ctagcagtat cctgagtacg gcgggacacg tgaaatcccg tcggaatctg ggaggaccat
     1081 ctcccaaccc taaatactcc ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg
     1141 aaaagcaccc cgggagggga gtgaaataga acctgaaacc gtgtgcctac aacaagttcg
     1201 agcccgttaa tgggtgagag cgtgcctttt gtagaatgaa ccggcgagtt acgttatgat
     1261 gcgaggttaa gttgaagaga cggagccgta gggaaaccga gtctgaacag ggcgaattag
     1321 tatcatgacg tagacccgaa accatgtgac ctacccatga gcaggttgaa ggtgcggtaa
     1381 gacgcactgg aggaccgaac cagggcacgt tgaaaagtgc ttggatgact tgtgggtagc
     1441 ggagaaattc caaacgaact tggagatagc tggttctctc cgaaatagct ttagggctag
     1501 cgtcgacatt agagattctt ggaggtagag cactgtttgg gtgaggggtc catcccggat
     1561 taccaatctc agataaactc cgaatgccaa tgaattatgg tcggcagtca gactgcgagt
     1621 gctaagatcc gtagtcgaaa gggaaacagc ccagaccacc agctaaggtc ccaaaataat
     1681 tgttaagtgg aaaaggatgt ggggttgcac agacaactag gatgttagct tagaagcagc
     1741 tattcattca aagagtgcgt aatagctcac tagtcgagtg accctgcgcc gaaaatgtac
     1801 cggggctaaa acaatttacc gaagctgtgg atacctttat aggtatggta ggagagcgtt
     1861 ctatgtgtga tgaaggtata ccgtgaggag tgctggaacg catagaagtg agaatgccgg
     1921 tatgagtagc gaaagacagg tgagaatcct gtccaccgta agactaaggt ttccagggga
     1981 aggctcgtcc gccctgggtt agtcgggacc taaggagaga ccgaaaggtg tatccgatgg
     2041 acaacaggtt gatattcctg tactagagta tgtagtgatg gagggacgca gtaggctaac
     2101 taaagcagac gattggaaga gtctgtctaa gcagtgaggt gtgaattgag tcaaatgctt
     2161 aattctataa cattgagctg tgatggggag cgaagtttag tagcgaagtt agtgacgtca
     2221 cactgccaag aaaagcttct agcgtttaaa catactctac ccgtaccgca aaccgacaca
     2281 ggtagtcgag gcgagtagcc tcaggtgagc gagagaactc tcgttaagga actcggcaaa
     2341 atgaccccgt aacttcggga gaaggggtgc tgactttagg tcagccgcag tgaataggcc
     2401 caagcaactg tttatcaaaa acacagctct ctgctaaatc gtaagatgat gtataggggg
     2461 tgacgcctgc ccggtgctgg aaggttaaga ggagtgctta gcgtaagcga aggtatgaat
     2521 tgaagcccca gtaaacggcg gccgtaacta taacggtcct aaggtagcga aattccttgt
     2581 cgggtaagtt ccgacccgca cgaaaggcgt aatgatttgg gcactgtctc aacgagagac
     2641 tcggtgaaat tttagtacct gtgaagatgc aggttacccg cgacaggacg gaaagacccc
     2701 atggagcttt actgcagttt gatattgagt gtctgtacca catgtacagg ataggtagga
     2761 gtctaagaga tcgggacgcc agtttcgaag gagacgctgt tgggatacta cccttgtgtt
     2821 atggccactc taacccagat aggtgatccc tatcggagac agtgtctgac gggcagtttg
     2881 actggggcgg tcgcctccta aaaggtaacg gaggcgccca aaggttccct cagaatggtt
     2941 ggaaatcatt cgcagagtgt aaaggtataa gggagcttga ctgcgagagc tacaactcga
     3001 gcagggacga aagtcgggct tagtgatccg gtggttccgt atggaagggc catcgctcaa
     3061 cggataaaag ctaccctggg gataacaggc ttatctcccc caagagttca catcgacggg
     3121 gaggtttggc acctcgatgt cggctcgtcg catcctgggg ctgtagtcgg tcccaagggt
     3181 tgggctgttc gcccattaaa gcggcacgcg agctgggttc agaacgtcgt gagacagttc
     3241 ggtccctatc cgtcgcgggc gtaggaaatt tgagaggatc tgctcctagt acgagaggac
     3301 cagagtggac ttaccgctgg tgtaccagtt gtcttgccaa aggcatcgct gggtagctat
     3361 gtagggaagg gataaacgct gaaagcatct aagtgtgaaa cccacctcaa gatgagattt
     3421 cccatgatta tatatcagta agagccctga gagatgatca ggtagatagg ttagaagtgg
     3481 aagtgtggcg acacatgtag cggactaata ctaatagctc gaggacttat ccaaagtaac
     3541 tgagaatatg aaagcgaacg gttttcttga attgaataga tattcaattt tgagtaggta
     3601 ttactcagag ttaagtgacg atagcctagg agatacacct gtacccatgc cgaacacaga
     3661 agttaagccc tagaacgccg gaagtagttg ggggttgccc cctgtg
//
LOCUS       DAVHIZ010000093         3620 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.095, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000093 DAVHIZ010000000
VERSION     DAVHIZ010000093.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3620)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3620)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3620
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.095"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1023
                     /locus_tag="VVO18_001946"
     CDS             <1..1023
                     /locus_tag="VVO18_001946"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001013545.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sugar transferase"
                     /protein_id="HEU5587029.1"
                     /translation="LVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDELSWK
                     LVAVSVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETM
                     GIDVTVNLKAFDKNLGRNKQIHEMVGLNVVTFSTNFYKTSHVIAKRIIDIMGALVGLI
                     LCGLVSIVLVPLIRKDGGSAIFAQTRIGKNGRQFTFYKFRSMCVDAEAKKRELMEQNT
                     MQGGMFKVDDDPRITKIGRFIRKTSLDELPQFYNVLKGDMSLVGTRPPTVDEYVQYTS
                     EQKRRLSFKPGITGLWQVSGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVF
                     MRDGAK"
     gene            1027..1770
                     /locus_tag="VVO18_001947"
     CDS             1027..1770
                     /locus_tag="VVO18_001947"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001205627.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="WecB/TagA/CpsF family glycosyltransferase"
                     /protein_id="HEU5587030.1"
                     /translation="MRDRIQLLGVTIDLLTMNETIDIVEQYVLEKRPLHLMGVNADKI
                     NQCHTDEKIKKIVNESGIINADGASVVLASKFLGTPVPERVAGIDLMQCLLELSNKKG
                     YSVYFFGAKEEVLQDMLKVFKRDYPNLIVIGHRNGYFSEEDEQAIQEDIREKNPDFVF
                     IGITSPKKEYIIQKFMDSGVNSVFMGVGGSFDVLSGHIQRAPLWMQKSNLEWLFRVAN
                     EPKRLFKRYFVGNISFIGKVLKAKRGVKY"
     gene            1767..2591
                     /locus_tag="VVO18_001948"
     CDS             1767..2591
                     /locus_tag="VVO18_001948"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076786.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LicD family protein"
                     /protein_id="HEU5587031.1"
                     /translation="MNQTEMIRLIQKVELDAIKEFKKICEENDIDFFLRGGSVLGAVK
                     YDGFIPWDDDMDIAVPREAYDKLPSVFKDRIIAGKYQVLTYQYCDTLHCYFPRLFLLE
                     DERKRLGLPRNTNLGLHLIDIIPLDGAPNHSVLRKIYFGKVYWYRFLASLGTTYVGDH
                     VDMHSTKQKLIIGFFKKLGFAKLFPQNSVYRRLDNLYRKYDWKKQKYAGTINASLFAK
                     EVMPVEIWGEGVEKPFEDTFFKVPTEYDRYLKRLYGENYLYEEPSDDEKKSHLGGH"
     gene            2593..3471
                     /locus_tag="VVO18_001949"
     CDS             2593..3471
                     /locus_tag="VVO18_001949"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458862.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5587032.1"
                     /translation="MFCYIILHYKVLEETISCVKSIKEGNYNAKQIVIIDNFSNNGTG
                     EKLQELYESDLEIDVLINHENAGFARGNNVAYQFAKEKYNPDFMVIMNNDIEIETENF
                     EKIVTDIYREEKFHLLGPDIFSTTYQLHQNPKRLTHYTYGEVKALNEKFKKGSQVSLA
                     LKIKCWLKASKVLRTAIYQNRRKKGSVDYRKQVENPILHGSFIVYSRDFIEKEEYAFN
                     PNTFFYYETEILDYEAELKGYKRIYTPKIRVLHHQNVATNQVYTNLLEKTLFSNKCNF
                     KSTSYFLKLMKENEDV"
BASE COUNT         1236 a          485 c          736 g         1163 t
ORIGIN      
        1 ttagtaaaga aatattggaa gcatgtgttt tttaatctaa aaaatagcaa gaaaatttta
       61 ctgttaacag taacgaaaaa tatggaaaaa gttcttgata aattgctaga atctgatgaa
      121 ctttcatgga aattggtagc agtaagtgtt ttggataaat ctgattttca acatgataaa
      181 atacctgtaa ttgaaaagga aaaaattatt gaatttgcaa cgcatgaagt tgtggatgag
      241 gtgtttgtca atcttccagg agagagctac gatattggag aaattatctc taggtttgag
      301 acaatgggga tagatgtaac tgtaaatctt aaagcatttg ataagaattt gggtcgcaat
      361 aaacaaattc atgagatggt aggattgaat gtagtcactt tctctacaaa tttttataaa
      421 actagtcatg taattgctaa gcggattatt gatatcatgg gtgcattggt agggctgata
      481 ctatgtggtt tagtcagtat tgtattggtt cctttgattc gaaaggatgg gggctctgct
      541 atttttgctc agacgcgtat aggaaaaaat ggtcgtcagt tcacttttta taagtttcgc
      601 tctatgtgtg tagatgccga ggcgaaaaaa agagaactca tggaacaaaa taccatgcag
      661 ggtggaatgt ttaaggtgga cgatgatcct cgtatcacga aaattggtcg ttttatacgg
      721 aagactagct tggacgagct accacagttt tataatgttc taaagggaga tatgagtttg
      781 gttggcacac ggccacctac agtggacgag tatgttcagt atacttcaga acagaaacgt
      841 cgactcagct ttaaacctgg tattacaggt ttatggcagg ttagcggccg tagtaaaata
      901 accgattttg acgatgttgt aaaattagat gtggcttata ttgataattg gacaatctgg
      961 aaagatattg aaattttgct taaaactgtt aaagttgtat ttatgagaga tggagcgaag
     1021 tgaggaatga gggatagaat ccaactttta ggtgtaacaa ttgatttgct tacgatgaat
     1081 gaaacgatag atattgtaga acaatatgta ttagaaaaaa gaccactaca cttgatgggg
     1141 gtgaatgctg ataaaattaa tcagtgtcat acagatgaga aaatcaaaaa aatcgttaat
     1201 gagtcaggaa tcattaatgc ggatggagca tcagttgttc ttgcaagtaa gtttttagga
     1261 acgcctgttc ctgaacgagt agcgggtatt gatttgatgc aatgtctttt agagttgtca
     1321 aataaaaaag gatattcagt ttactttttt ggagcaaaag aagaagtttt gcaagatatg
     1381 ctcaaagtat ttaagagaga ttatccaaat ttgatagtta ttggacacag aaatggctat
     1441 ttttctgaag aggatgaaca agctattcaa gaagatattc gtgaaaagaa ccctgatttt
     1501 gtgtttattg gaattacgtc tcctaaaaaa gaatatatta ttcaaaaatt tatggatagt
     1561 ggcgtcaatt cggtatttat gggagttggc ggtagttttg atgtcttgtc tggtcatatc
     1621 caacgagcac ctctatggat gcaaaagtca aatttagagt ggttattccg tgtagctaat
     1681 gagcctaaac gtctctttaa acgttatttt gtagggaata tttcattcat aggaaaagtt
     1741 ttaaaagcaa aaagaggtgt aaaatattga accagacaga gatgattcgc ttaattcaaa
     1801 aagttgaatt agatgctata aaagagttta aaaaaatctg tgaagagaat gatatagatt
     1861 ttttcctccg cggtggtagt gtacttggtg cggtcaaata cgacggcttt attccatggg
     1921 atgatgatat ggatatcgct gtccctcgtg aagcatacga caaacttcca agtgttttca
     1981 aagatagaat tatcgctggg aaatatcagg ttcttactta tcaatactgt gatacgttgc
     2041 attgctactt tcctcgacta ttccttttag aagatgaaag aaaacgtttg ggcttgccac
     2101 gaaataccaa tctaggattg catttgattg atatcattcc tttagatgga gcaccaaatc
     2161 attcggtttt aagaaagatt tactttggca aagtatactg gtatcgtttt ttagcaagtt
     2221 taggaacaac ttatgttggc gaccatgtgg atatgcattc cactaagcaa aaactaatta
     2281 ttggtttctt taaaaaacta ggatttgcaa aactatttcc tcaaaattct gtatacagac
     2341 gcttggataa tctctataga aagtatgatt ggaaaaagca gaagtatgcg gggactatca
     2401 atgcttcttt atttgctaaa gaagttatgc cagtagagat ttggggagaa ggagtagaga
     2461 agccttttga ggataccttc tttaaagttc caacggagta tgatcgctac ctgaaaagac
     2521 tttacggaga aaactatctt tacgaagagc ctagtgatga tgaaaagaaa tcgcatttag
     2581 gaggacacta atttgttttg ttatattatt ttgcattaca aagtcttaga agaaactatt
     2641 tcttgtgtta aatctataaa agaaggcaat tataatgcaa agcaaatcgt tattattgat
     2701 aatttctcta ataatggtac tggtgaaaaa ctacaagagc tttatgaatc agatttagaa
     2761 attgatgttt tgattaacca tgaaaatgct ggttttgctc gtggaaataa tgtggcttat
     2821 caatttgcta aggaaaagta taaccccgat ttcatggtta tcatgaataa cgatattgag
     2881 atagaaacag aaaattttga aaaaattgtg acagatatct atcgtgagga aaaattccat
     2941 ttgctcgggc cagatatctt ctcgactact taccaacttc accaaaaccc aaaacggttg
     3001 acacattata cttatggaga agttaaagct ctaaatgaaa aatttaaaaa agggagccaa
     3061 gttagtctag ctttaaaaat caaatgttgg ttgaaagcta gtaaagttct tcgaacagca
     3121 atctatcaaa atagacgtaa aaaaggatca gtagactata gaaaacaggt agaaaaccca
     3181 attcttcatg gttcttttat tgtatattcg agagatttta tcgaaaaaga ggagtatgct
     3241 tttaacccta acaccttctt ttactatgaa acagagatat tagattatga agctgaatta
     3301 aaaggataca agagaattta tacacctaaa attagagttt tgcaccatca aaatgttgca
     3361 actaatcaag tttacacgaa cttgttagaa aaaaccttgt tttcaaataa atgcaacttt
     3421 aaatccacca gttatttttt gaagttgatg aaagaaaacg aggatgttta aatgagttat
     3481 ttatttttac tttgccttac attattctta ttgactatat tctatttctt tgcttttatt
     3541 caagatttaa ttgctcctcc agtagttatg tctgtaatgt ttctaattag ttcagtattt
     3601 gcactggtta attcaaaaaa
//
LOCUS       DAVHIZ010000094         3597 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.096, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000094 DAVHIZ010000000
VERSION     DAVHIZ010000094.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3597)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.096"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(182..793)
                     /gene="rpsD"
                     /locus_tag="VVO18_001950"
     CDS             complement(182..793)
                     /gene="rpsD"
                     /locus_tag="VVO18_001950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407971.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S4"
                     /protein_id="HEU5587033.1"
                     /translation="MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKL
                     SEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRL
                     GLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATL
                     GRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML"
     gene            complement(988..2040)
                     /locus_tag="VVO18_001951"
     CDS             complement(988..2040)
                     /locus_tag="VVO18_001951"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000769768.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HAMP domain-containing histidine kinase"
                     /protein_id="HEU5587034.1"
                     /translation="MKLKSYILVGYIISTLLTILVVFWAVQKMLIAKGEIYFLLGMTI
                     VASLVGAGISLFLLLPVFTSLGKLKEHAKRVAAKDFPSNLEVQGPVEFQQLGQTFNEM
                     SHDLQVSFDSLEESEREKGLMIAQLSHDIKTPITSIQATVEGILDGIIKESEQAHYLA
                     TIGRQTERLNKLVEELNFLTLNTARNQVETTSKDSIFLDKLLIECMSEFQFLIEQERR
                     DVHLQVIPESARIEGDYAKLSRILVNLVDNAFKYSAPGTKLEVVAKLEKDQLSISVTD
                     EGQGIAPEDLENIFKRLYRVETSRNMKTGGHGLGLAIARELAHQLGGEITVSSQYGLG
                     STFTLVLNLSGSENKA"
     gene            complement(2037..2735)
                     /locus_tag="VVO18_001952"
     CDS             complement(2037..2735)
                     /locus_tag="VVO18_001952"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000520636.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /protein_id="HEU5587035.1"
                     /translation="MGKTILLVDDEVEITDIHQRYLIQAGYQVLVAHDGLEALELFKK
                     KPIDLIITDVMMPRMDGYDLISEVQYLSPEQPFLFITAKTSEQDKIYGLSLGADDFIA
                     KPFSPRELVLRVHNILRRLHRGGETELISLGNLKMNHSSHEVQIGEEMLDLTVKSFEL
                     LWILASNPERVFSKTDLYEKIWKEDYVDDTNTLNVHIHALRQELAKYSSDQTPTIKTV
                     WGLGYKIEKPRGQT"
     gene            complement(2902..>3597)
                     /locus_tag="VVO18_001953"
     CDS             complement(2902..>3597)
                     /locus_tag="VVO18_001953"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000671383.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="fibronectin-binding SSURE repeat-containing
                     protein"
                     /protein_id="HEU5587036.1"
                     /translation="AKGEGPFTAGVNHVIPYELFAGDGMLTRLLLKASDKAPWSDNGE
                     AKNPALSPLGENVKTKGQYFYQVALDGNVAGKEKQALIDQFRANGTQTYSATVNVYGN
                     KDGKPDLDNIVATKKVTIKINVKETSDTANGSLSPSNSGSGVTPMNHNHATGTTDSMP
                     ADTMTSSTNTMAGENMAASANKMSDTMMSEDKAMLPNTGETQTSMASIGFLGLALAGL
                     LGGLGLKNKKEEN"
BASE COUNT          981 a          811 c          704 g         1101 t
ORIGIN      
        1 agattatacc acattgtgta ctatttttgg ttcattttac tatatcactt tggactatat
       61 cggtctagtt atgtctaaac gattatagct ggatactaag agaaatcaaa aaagcactaa
      121 gagagaacgt cccaaagtgc ttaatatcaa ggcctcaaag cctatcttat ttaataaaat
      181 attacaacat tttgttgtag aattcaacga caagtgcttc gttgatttct gggttgattt
      241 cgtcgcgttc tggcaagcga gtcaatgaac cttccaactt ttcagcgtcg aatgatacga
      301 atgctggacg tccaagagta gcttctactg cttcaaggat tgctggaact ttcaatgatt
      361 tttcacgaac tgagatcact tgacctggag ttacgcggta tgatgggata tcaacgcgtt
      421 tcccgtcaac aaggatgtga ccgtggttta cgaattgacg agcttgacga cgagtagtcg
      481 cgagaccaag acggtaaaca acgttatcca aacgacgttc caaaagaagc ataaagttga
      541 aacctaggat tccgcctttg atttttgtag cttgtacgaa caagttacgg aattgttttt
      601 cacctacacc gtaagtgaaa cgaagttttt gtttttcagc caattgcaaa ccgtattctg
      661 acaatttaga acggttgttt ggtccgtgtt gtcctggtac gtagttacga cgtgccaatt
      721 ctttacctgt acctgtaagt gaaaggccaa ggcgacgagc ttgtttccaa gatggtcctg
      781 tataacgtga catatgaatg tcctcctgat ataaataata tttcggtgga aatagtcact
      841 tagaaagccc tgattcgtgc agatgccctt cgcctaaaca gccaaggtta cttgtcataa
      901 gacacctgtt gacgagcttc atgctttcct gctgatattt cacacaaaat ctattctacc
      961 atgaatagct ggatttgtaa aggggtttta ggctttattt tcactaccag agaggttgag
     1021 aacgagggta aaggtacttc ctagaccgta ctggctgctg actgtgattt ccccacccaa
     1081 ttgatgggcc aattcacgcg caatcgcaag tcctaatcca tgaccacctg tcttcatgtt
     1141 acgcgaagtt tcgacacgat aaagacgttt gaaaatattt tccaaatcct ctggggcaat
     1201 accctgccct tcatcggtca cactgattga aagctggtcc ttctccagct tagccaccac
     1261 ttccagcttg gttcctggag cagaatattt aaaagcgtta tcgaccagat tcaccaagat
     1321 acgagaaagc ttagcataat ctccctcaat ccgggcagac tctgggatta cctgcaagtg
     1381 gacatctctt ctctcctgct caatcaaaaa ctgaaattca ctcatgcact caattaagag
     1441 cttgtccaga aaaatactgt ctttactggt agtttccacc tgatttctag ctgtgtttag
     1501 ggtcaaaaaa ttcaactcct caaccagttt attgagcctc tccgtctggc gtccaatggt
     1561 tgctagataa tgagcttgct ccgactcctt gataatccca tccaaaatcc cttctaccgt
     1621 cgcttgaatc gaagtgatag gggtcttaat atcatgcgac aactgggcaa tcatcaagcc
     1681 cttttctcgt tcgctttctt ccaaggaatc aaagcttacc tgcaaatcat gggacatctc
     1741 attaaaagtt tgccctaatt gctgaaattc tacaggacct tgaacctcca aatttgaagg
     1801 aaaatccttg gccgctaccc gcttggcatg ctccttgagt ttgcccaacg acgtaaagac
     1861 tggcaatagg agaaagagac taatcccagc accgacaagg ctggcaacga tggtcatccc
     1921 aagcaaaaag taaatctcgc ctttcgcaat cagcattttt tgaacagccc aaaaaacaac
     1981 caaaatggtt aagagggttg aaataatata tccaaccaaa atataacttt ttagtttcat
     2041 gtttgtcctc tcggtttctc tatcttatat cccaaccccc aaactgtctt aatagtgggc
     2101 gtttggtcac tactatattt tgccagctcc tgtcgaagag catggatatg cacattcaag
     2161 gtattggtgt catccacgta gtcttctttc cagatctttt catagaggtc tgtcttggag
     2221 aaaactcgct ctggattgct agctaaaatc cacagcaatt caaatgattt aacagttaaa
     2281 tccagcattt cttctcctat ttgaacttca tgactactat gattcatttt tagattgcca
     2341 agggaaatca gctctgtttc gcccccacga tgaaggcggc gcaaaatatt gtggacacgc
     2401 aaaaccagct cacgtgggct aaaaggctta gcaataaaat catctgctcc caagctcagg
     2461 ccgtaaatct tgtcctgttc actggtctta gcagtaataa ataggaaagg ctgctctggt
     2521 gataagtatt gaacctcact gattaaatca taaccatcca tccgaggcat catgacatct
     2581 gtgataatca aatcaatcgg ttttttcttg aacagctcta gcgcttccag tccatcatgg
     2641 gctaccaaga cctgataacc tgcctgaatt aagtatctct gatgaatatc tgtgatttct
     2701 acctcgtcgt caacgagtaa aattgtcttt cccatctgtc tctcctttga taaaaacagt
     2761 gctatactgc tttaagtata acactatttt tattgtttta cgatgatttt aatctgctat
     2821 tgaaagaaag tcctgattgc tgattgagtt gttaaactaa tcttagtcag cccactatcc
     2881 atcatttatt tccttagctg attagttttc ttcttttttg tttttcaaac ctagaccacc
     2941 gagtaaacct gcaagcgcaa gcccaaggaa accaatactt gccattgatg tttgagtctc
     3001 accagtattt ggtagcatag ctttatcctc tgacatcatc gtatcagaca tcttgttagc
     3061 agaagcagcc atgttttcac ctgccatcgt gttggtagaa cttgtcatgg tgtcagcagg
     3121 catgctatct gtagtacctg tagcatgatt gtgattcatc ggagtcacgc cagaaccaga
     3181 gttagaaggt gataatgaac catttgctgt gtctgatgtt tctttaacat ttatcttaat
     3241 agtgactttt ttagttgcta cgatgttgtc caagtctggt ttaccgtctt tgttaccata
     3301 gacattgact gtagcgctgt aagtttgagt accgtttgct cggaactggt caatgagcgc
     3361 ttgtttttct ttgccagcta catttccgtc caaggctact tgatagaagt attgaccttt
     3421 ggtcttcacg ttttcaccta gtggagatag ggctgggttt ttagcctcac cgttatctga
     3481 ccatggtgcc ttgtcagatg ccttgagcaa gagacgagtc aacataccat cacctgcgaa
     3541 gagttcgtat ggaatcacat ggttgacacc tgctgtgaat ggaccttcac ccttggc
//
LOCUS       DAVHIZ010000095         3539 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.097, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000095 DAVHIZ010000000
VERSION     DAVHIZ010000095.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3539)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.097"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..908
                     /locus_tag="VVO18_001954"
     CDS             <1..908
                     /locus_tag="VVO18_001954"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001847123.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="HEU5587037.1"
                     /translation="LYLIGYLLAAMKIKDSLDASKEGLMEIFYLSPKIERLKEIQNQD
                     LQEGDDYSLKKFDIDLKDVEFAYNKDAKVLNGVSFKAKQGEVTALVGASGCGKTTILK
                     LISRLYDYDKGQILIDGKDIKEISTESLFDKVSIVFQDVVLFNQSVMENIRIGKQDAS
                     DEEVKRAAKLANCTDFIEKMDKGFDTVIGENGAELSGGERQRLSIARAFLKEAPILIL
                     DEITASLDVNNEKKIQESLNNLVKDKTVVIISHRMKSIENADKIVVLQNGRVESEGKH
                     EELLQKSKIYKNLIEKTKMAEEFIY"
     gene            919..1503
                     /locus_tag="VVO18_001955"
     CDS             919..1503
                     /locus_tag="VVO18_001955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000368966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MptD family putative ECF transporter S
                     component"
                     /protein_id="HEU5587038.1"
                     /translation="MDNKKLKVKDLVSIGVFGVIYFAFMFGVGMMGLIPILFLIYPTV
                     LAIVAGTVVMLFMAKVQKPWALFIFGMISPLVMFAAGHTYVVVVLSLIVMIIAELIRK
                     IGNYNSFKYNMLSYAIFSTWICSSLMQMLLAKEKYMEWSLMTMGKDYVDVLEKLIIYP
                     HMALVALGAFLGGILGAYIGKALLKKHFEKAGIV"
     gene            1503..2198
                     /locus_tag="VVO18_001956"
     CDS             1503..2198
                     /locus_tag="VVO18_001956"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001141947.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="HEU5587039.1"
                     /translation="MPTFSSNAPFNPNPISKILVVFITGLTVMHSINIRFELAIVCLI
                     GILLYLNGYKKTLFKWIILCGILYSLPNFMVLSELNPIVKMFLSIPIVIRMFILPFMA
                     ASFMIKTSDVGAIISSMDKLKISKNVSIPIAVMFRFFPSFKEEKKNIKMAMRVRGINF
                     KNPVKYLEYVSVPLLIISSNISDDIAKAAETKAIENPIAKTRYIRVKIQLIDFVYVLA
                     VAGLIVGGLIWLK"
     gene            2186..>3539
                     /locus_tag="VVO18_001957"
     CDS             2186..>3539
                     /locus_tag="VVO18_001957"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002837029.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587040.1"
                     /translation="MVEIKNLSLDYGEEHILDDISLSIAEGECVLFTGKSGSGKSSLI
                     NSINGLAVRYDNAKTKGEIIIDGKNIKNLELYQISMLVSTVFQNPKTYFFNVNTTLEL
                     LFYLENIGLAREEMDRRLKDMLEIFPIKNLLNRNIFNLSGGEKQILCIAASYIAGTKI
                     IVMDESSSNLDIKSISVLAKMLKILKEKGISIIVAEHRIYYLMDIVDRVFLIDKGKLK
                     KTYTRSEFLKLDKNKLNALSLRDKELSKLKVPYLKEGGEYQIKNLSYKFTDDECLSLK
                     DISFKLGKIYGIIGSNGRGKSTLLRCLIGLEKKSKEEIYFKGEKLSKKERLKNSSLVM
                     QDVNHQLFTDEVFNELRLGIKNFDEEKAKIILKDLGLDEFIERHPMSLSGGQKQRLAI
                     ASVMCKTSPFIFFDEPSSGMDYSNMIKISELINKYKTMDKIIFIVSHDIEFLNEVADE
                     I"
BASE COUNT         1298 a          443 c          676 g         1122 t
ORIGIN      
        1 ctctctacct tataggatat ttactagctg ctatgaagat aaaagactct ttagatgcat
       61 ctaaagaggg cttgatggaa atattttatt tatcgcccaa aatagaaaga ttaaaagaaa
      121 ttcaaaatca agatttacaa gaaggcgatg actatagctt aaaaaaattt gatattgatc
      181 taaaagatgt tgagtttgcc tacaataaag acgcaaaagt tttaaacggt gtaagtttta
      241 aagctaagca gggagaggtc actgctttgg taggtgcaag tggctgcggt aaaacaacta
      301 tcttgaaact tatatcaaga ctttatgatt atgacaaggg acaaatctta attgatggca
      361 aagatataaa ggaaatatca acagaatccc tttttgataa ggtgtctatt gttttccaag
      421 atgtggttct ctttaatcaa agcgttatgg aaaatattag aatcggtaag caagatgcaa
      481 gtgacgaaga ggttaaaaga gcagcaaaac ttgcaaattg cacagatttt atagaaaaaa
      541 tggataaagg tttcgataca gttattggtg agaacggagc tgagctatca ggaggagaaa
      601 gacaaagatt atcaatagcc agagccttct taaaagaagc gccgatattg atcttagatg
      661 agataacagc aagccttgat gttaacaacg agaaaaagat tcaagagtct ttaaataatt
      721 tagttaaaga taaaactgtt gtaatcattt cacatagaat gaaatccata gaaaatgcag
      781 acaagatagt agttcttcaa aacggaagag tagaaagcga aggtaagcat gaagagcttt
      841 tacaaaaatc aaaaatttac aaaaatttaa tagaaaagac aaaaatggca gaagaattta
      901 tttattagga ggactacaat ggataataaa aaattaaaag taaaagattt agtaagtatc
      961 ggtgtttttg gcgtaattta ttttgccttc atgtttggag ttggtatgat gggcttgatt
     1021 ccaatattgt tcttaatata cccgacagta ttagccatag ttgcaggaac tgttgttatg
     1081 ttatttatgg ctaaggttca aaagccatgg gcactattta tatttggtat gatatcacca
     1141 cttgtgatgt ttgcagctgg tcatacctac gtagttgtgg ttttatcact tatagtaatg
     1201 ataatagcag aattaattag aaagattggt aattataatt catttaaata caatatgctt
     1261 tcttatgcaa tcttcagcac atggatatgt agctctttaa tgcaaatgct tttagcaaaa
     1321 gaaaaatata tggagtggtc tttgatgacg atgggaaaag attatgttga tgtattagaa
     1381 aagttaataa tttatcctca catggcttta gtagccttag gtgctttctt aggaggaatt
     1441 cttggagcat atataggcaa ggctctattg aaaaaacact ttgaaaaagc aggcatcgta
     1501 taatgcctac tttttcttca aatgctccct ttaatcccaa tccgatctct aagatattag
     1561 tcgtatttat cacaggctta actgttatgc atagcataaa catccgtttt gagctggcaa
     1621 ttgtttgtct tattggtatt ttgctttatt tgaatggata caaaaaaaca cttttcaaat
     1681 ggattatatt gtgtgggata ctttactcct tgcctaattt tatggtgtta tctgaattaa
     1741 accctatagt taagatgttt ttgagtatac ctattgttat tagaatgttt attttaccat
     1801 ttatggcagc aagctttatg ataaagacct cggatgtagg cgcaataatt tcatcgatgg
     1861 ataagcttaa gatttcaaag aatgtatcca tacctattgc ggttatgttt agattcttcc
     1921 catcttttaa ggaggagaag aaaaacatca aaatggctat gagagtaaga gggataaatt
     1981 ttaaaaaccc agtcaaatat cttgaatatg tttctgtgcc actactcatt atatcatcta
     2041 atatatcaga tgacattgca aaagcggcag aaacaaaggc aatagaaaat ccaattgcca
     2101 agaccagata cattcgcgta aagatacagc taattgattt tgtttatgtt ttagcggttg
     2161 ctggacttat tgtgggaggc ttaatatggt tgaaataaaa aatttaagtc ttgattatgg
     2221 tgaagagcat atattagatg atatatcact atccatagcc gagggagagt gcgtgctatt
     2281 tacaggaaaa agtggaagtg gtaagtcatc tttaataaat tcaatcaatg gactagctgt
     2341 aaggtatgat aacgcaaaga caaagggcga aataattatt gatggtaaga atataaaaaa
     2401 tttggaactt tatcaaatct caatgcttgt ttcaactgtt tttcaaaatc ctaagacata
     2461 tttttttaat gtcaatacga cattagaatt attattttat ttggaaaata tcggtcttgc
     2521 aagagaagag atggacaggc gtttgaagga tatgcttgag atattcccga taaaaaatct
     2581 tttgaacaga aatatattta atctatccgg cggtgaaaaa caaattcttt gcattgcagc
     2641 ttcttatata gcaggtacaa agattatagt tatggatgag tcttcatcga atttagatat
     2701 taaaagcata agtgttttgg caaagatgct aaagatatta aaagagaaag gcataagcat
     2761 aattgttgca gagcatagaa tttattattt gatggacata gttgaccgtg tatttttaat
     2821 agataaagga aagcttaaaa aaacttatac tagaagtgaa tttttaaagc tagataaaaa
     2881 taaattaaat gctttaagtt taagagataa agaattaagt aaattaaaag ttccttattt
     2941 aaaagaaggt ggagagtatc agataaaaaa tcttagctac aaatttactg atgatgagtg
     3001 tttaagctta aaagatattt cattcaagct tgggaaaatt tatggcataa taggatccaa
     3061 cggacgagga aaatcaacgc ttttaagatg tttaataggt cttgagaaaa aatcaaaaga
     3121 agaaatttat tttaagggag agaagctatc taaaaaagaa agactcaaaa actcttcact
     3181 tgttatgcaa gatgtaaatc atcaattatt cacagatgag gtattcaacg agcttagatt
     3241 aggaataaag aattttgatg aagaaaaggc gaaaatcatt ttaaaagatt taggcctgga
     3301 cgaatttatt gaaaggcatc cgatgagttt atcaggaggg caaaagcaaa ggcttgcaat
     3361 agcatctgtt atgtgcaaga cttctccatt tatctttttt gacgaacctt caagtggtat
     3421 ggattattcc aatatgataa aaatatctga actgattaat aagtataaaa ccatggataa
     3481 aataattttt attgtttccc atgatataga atttttaaat gaagtggcag atgaaattt
//
LOCUS       DAVHIZ010000096         3537 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.098, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000096 DAVHIZ010000000
VERSION     DAVHIZ010000096.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3537)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.098"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            142..1153
                     /locus_tag="VVO18_001958"
                     /pseudo
     CDS             142..1153
                     /locus_tag="VVO18_001958"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000669441.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal-type histidine triad protein"
     gene            complement(1424..1645)
                     /locus_tag="VVO18_001959"
     CDS             complement(1424..1645)
                     /locus_tag="VVO18_001959"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001844654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587041.1"
                     /translation="MDLFQELICLVQKTFYFFLAICRRLLVAIYHVLLKQESYNPRLQ
                     GLTEIRNPDKTMFVQDAIRFAQQHGFNML"
     gene            1610..2239
                     /locus_tag="VVO18_001960"
     CDS             1610..2239
                     /locus_tag="VVO18_001960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000030436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587042.1"
                     /translation="MNKANQLLEQIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQ
                     VKDVLTRIASALQQEKENAEQDSQTLVLYQKLYDILMSLHSYLESNNGSDADFDKVDA
                     LLDQLSANSKDKTALLESTKAILVLNHQIQSKASASEETSPAKNAEANGDNTSAENQP
                     NATAESNIETASDENKPSNTRDSKPAESTSENETTESSTTTGNQEKPVE"
     gene            complement(2275..3498)
                     /gene="pepT"
                     /locus_tag="VVO18_001961"
     CDS             complement(2275..3498)
                     /gene="pepT"
                     /locus_tag="VVO18_001961"
                     /EC_number="3.4.11.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222045.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptidase T"
                     /protein_id="HEU5587043.1"
                     /translation="MTYPNLLDHFLTYVKVNTRSDEHSTTTPSTQSQVDFATNVLIPE
                     MKRVGLQNVYYLPNGFAIGTLPANDPSLTRKIGFISHMDTADFNAEGVNPQVIENYDG
                     GVIELGNSGFKLDPADFKSLEKYPGQTLITTDGTTLLGADDKSGIAEIMTAIEYLTAH
                     PEIKHCEIRVGFGPDEEIGVGANKFDAEDFDVDFAYTVDGGPLGELQYETFSAAGAEL
                     HFQGRNVHPGTAKGQMVNALQLAIDFHNQLPENDRPELTEGYQGFYHLMDVTGSVEET
                     RASYIIRDFEKDAFEARKASMQSIADKMNEELGSDRVTLNLTDQYYNMKEVIEKDMTP
                     ITIAKAVMEDLGITPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTM
                     ERAVDTIIGIVAYKG"
BASE COUNT         1196 a          659 c          668 g         1014 t
ORIGIN      
        1 tttattatta atatataaaa tttcttgaca tacaacttaa aaagaggtgg aatatttact
       61 agttaattaa ttggttaatt aatttattta atcatttaat aatgaagaca tcatataaat
      121 aattatagaa atgaggtaat tatgaaattt aaaaagaaat atatagcatc tggatctgtt
      181 gttatccttt ccttaagtct gtgtgtttat gctctgaacc aacatagcta acaggccaat
      241 acagataaaa atcgtgtttc atatgtaaac agtaataaag acactaagaa gactgaaaat
      301 ttgactccag actaggttag tcaaaaagaa ggaattcaag caaaacaaat tgttattaag
      361 attacagatc aaggttatgt aacttctcat ggcgatcatt atcactacta taatggtaaa
      421 gttccttttg atgcgctctt tagtgaagag ctattaatga aagcccccaa ctatcagccg
      481 aaagatcaag atatcgtcag ttaggttaag ggaggatata ttattaaggt agatggaaag
      541 tattatgttt accttaaaga tcaagctcat gcagaaaatg tacgaacaaa agatgaaatc
      601 aatcgccaaa aacaagaaca tggtaaagac gataaaggag ctagtgcaga agtatctgta
      661 gcaaaattac agggacgtta tactaccgat gatggttata tatagtgagt tgaatttaga
      721 atagcacatc atagtttcta aatcattgtt agaaattact ttaaaatccc cttatcaatt
      781 tgctcatatt ctatttcaac ctactatagt accacatggt ggtcactatc atttcattcc
      841 tgagagtgac ttgtcggcag gtgaattagc agccacatat gtctttaacc ctaatgatat
      901 tgtcagagat ataggtgatg cttatatagt aagacatggg gatcactatc actatattcc
      961 taagtcatct tttaacaatc ccccatcaca ctctaacacg gaagaggtag gaagttcttc
     1021 tagttctgta ttaagtaatc cgtcactaca tgtccaccat gaggaagaag atggtcatgg
     1081 ttttgatgcc aatcgaatta taagtgaaga ttcagaaggt tttgtgattc ctcatggcga
     1141 ccacaatcac tacatcaagg ttcaaactaa gggatatgaa gcggctttga aaaacaagat
     1201 tccatccctg caatccaact atcaacctgg aacttttgat gagaaggcag tcttggcaaa
     1261 agtagatcaa cttctagctg atagcagaag catctacaaa gacagattga gttagcttta
     1321 gatcagttta ctgaaagttt gaaaaaaata aaagttagtt gattgattac ttctctaaat
     1381 tttgggcaca ctaaaaagag gtcttgacac ctaaacttta aaattaaagc atattgaatc
     1441 cgtgctgctg tgcgaagcga atagcgtctt ggacgaacat tgtcttatct ggatttctta
     1501 tttctgtaag gccttgtaat cttggattat aactctcctg ttttaggagt acatggtaga
     1561 tagcaaccaa taatctgcga cagatagcaa ggaagaagta gaaagtcttt tgaacaaggc
     1621 aaatcaactc ttggaacaaa tccatgaaga aggaatcaga caatccttgg cagaagaagt
     1681 agaaaatcta aaagctgcca caaacaaggc tgatgcagac ttggatgaag taaacagtca
     1741 ggtaaaagat gttttgactc gtatcgctag cgcccttcaa caagaaaagg aaaatgctga
     1801 gcaagattct cagacacttg tactctatca aaaactctac gatattctca tgtcgcttca
     1861 ctcttattta gaaagtaata atggatctga tgcggacttt gataaggtgg atgcattatt
     1921 agatcaactt tctgctaata gtaaagacaa aacagcttta cttgaatcga caaaagctat
     1981 tctagttttg aatcatcaaa tccagtcaaa agctagcgca agtgaagaaa caagtccagc
     2041 aaaaaatgct gaagcaaatg gtgataacac cagtgctgag aaccaaccaa acgcaactgc
     2101 agaatctaac attgaaactg ctagcgatga aaacaaacca agcaatacaa gagattctaa
     2161 acctgctgaa tcaacttcag aaaatgaaac aacagaatct tctacaacta ctggaaatca
     2221 agaaaaacca gtagaataaa aagaaaggcg aagtagctga gccacctcgt ctttttagcc
     2281 tttataagct acgatgccaa tgatggtatc aactgcacgt tccatagtct gaaggctaac
     2341 gtattcaaaa cgtccgtgca tattttcgcc acctgcaaag atattcggag ttgggattcc
     2401 cataaaggaa atcttagagc cgtctgttcc accccggatt ggttcgataa taggcgtgat
     2461 acctagatct tccataacgg ctttagcaat ggtaattgga gtcatatctt tttcaatgac
     2521 ttctttcata ttgtagtact ggtctgtcaa gttgagagtg acacggtcgc tcccaagttc
     2581 ttcattcatc ttatcagcga tagattgcat ggatgcttta cgcgcttcaa aggcatcttt
     2641 ttcaaaatca cgaatgatgt agcttgcacg cgtctcctca acactacctg tcacatccat
     2701 tagatggtaa aaaccttggt aaccttcagt taactcaggt cggtcatttt ctggaagttg
     2761 attatgaaaa tcaattgcta gctgaagggc attgaccatc tgccctttgg cagtaccagg
     2821 gtggacatta cggccttgga aatgcaattc agcaccagcg gctgagaaag tctcgtactg
     2881 aagttcacct agtggaccac cgtcaacagt gtaggcaaaa tccacatcaa aatcttctgc
     2941 atcaaattta ttggcaccaa caccgatttc ttcatctgga ccaaaaccaa cacgaatctc
     3001 acagtgctta atttcaggat gagcagttag atattcaatg gctgtcataa tttcagcaat
     3061 tcctgacttg tcatcagcac ctagcaaggt tgttccatct gttgtgatga gcgtttgtcc
     3121 tggatatttt tcaagactct tgaagtcagc tggatcgagt ttgaaaccag aattccctag
     3181 ttcaatcaca ccaccatcgt agttttcaat tacctgtgga ttgactcctt cagcattaaa
     3241 atcagcagta tccatgtgcg atataaaacc aatcttacgt gttaaagacg gatcgttggc
     3301 tggcaaggtt ccaatagcaa aaccattcgg tagatagtaa acattttgca gtccaacacg
     3361 tttcatttca ggaattagga catttgttgc gaagtcaacc tgactctgtg tacttggagt
     3421 agtagtagag tgttcatcag agcgcgtgtt gaccttaacg taggttaaga agtggtccaa
     3481 gagatttgga taagtcataa aaaaactcct tttttatcat aaaatagaat acaaaac
//
LOCUS       DAVHIZ010000097         3452 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.099, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000097 DAVHIZ010000000
VERSION     DAVHIZ010000097.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3452)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3452)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3452
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.099"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..410
                     /locus_tag="VVO18_001962"
     CDS             <1..410
                     /locus_tag="VVO18_001962"
                     /inference="COORDINATES: ab initio
                     prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587044.1"
                     /translation="LQKDKDTTFAPFDSLFKHSIIFLHSYKNISDERAYFLISLNNKK
                     RKLKPADNLYSHFISFTSVLRTLAYFLALVKCRVTGLNTPLLSLRKPKTAELLFLSSK
                     NMTSNFIVFLDKSLATMQQLVSLDIEDIADKLT"
     gene            complement(425..664)
                     /locus_tag="VVO18_001963"
     CDS             complement(425..664)
                     /locus_tag="VVO18_001963"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000770310.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587045.1"
                     /translation="MKLLDCILDYQERFNGKTCQVSTNYKYLEIFKVNFCLTDLHHLF
                     GLHKITRDYASQTKPAIQAGVFILEDFRNILCTMM"
     gene            complement(1799..2527)
                     /locus_tag="VVO18_001964"
     CDS             complement(1799..2527)
                     /locus_tag="VVO18_001964"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866696.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587046.1"
                     /translation="MSNVDKIRKIHIIVCWVYIFLSFRAIINDTEYFLLIFLAFIYSI
                     VSLPLYSVKNKIVSICLVINSILLISFPILINKFFPESFLTYTVLISVFILELAIFHL
                     IGKDFDTKLTNEYKKISQFRSKVSQSPWIKYLEISSFILTIFPSILYGTVDNHVLTLI
                     FLIKICVDTTIKFLFIRLFDTSTLMKRRIFFLFALDVIAYLFLGYLLVIQKAGYLFSV
                     LLLFSNFSVPFIKAKEYELFKNSK"
     gene            complement(2524..2877)
                     /locus_tag="VVO18_001965"
     CDS             complement(2524..2877)
                     /locus_tag="VVO18_001965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEU5587047.1"
                     /translation="MELVLPNNYVVIDEEEMMYLDGGAYLSKRACQGICAALAMSSGT
                     FIALAGAAVLTKKLINYIKVGGLGGWLIGAAAGVLATAAGKIAYCIGYGVLNRGCDIN
                     GNPYPWDGFISATVR"
     gene            complement(2933..>3452)
                     /locus_tag="VVO18_001966"
     CDS             complement(2933..>3452)
                     /locus_tag="VVO18_001966"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587048.1"
                     /translation="FVIIMLTTIFFWNIMDINHLVFNKTEFLFNQNKWEKEDSFESDL
                     TKTLKDKIQKSELSYSDLMSLQLYDAMNQSTFLTDSELFEDILSKIEDSHNTLLCTGL
                     VELLLYEISISNNNNWQEKVDKIRIHLIRINQLDFFYYTSWLRQNFDFCMNREYHKMK
                     SRKLLLSNKKIV"
BASE COUNT         1219 a          634 c          453 g         1146 t
ORIGIN      
        1 tactccaaaa agataaagac actacttttg cccctttcga ttctcttttt aaacatagca
       61 tcatcttcct tcattcctat aaaaacattt ccgatgagag agcttatttt ttaatttcgt
      121 taaacaacaa aaaacgcaag cttaagcctg cggacaatct ttatagccat ttcatttctt
      181 tcacatctgt tttacgaact ttagcatatt tcttagcgct tgtaaaatgt agagtaactg
      241 gtttaaatac tccgcttttg tctcttcgta aacctaaaac tgcggaactt ttatttttat
      301 cctcaaaaaa tatgacgtcc aatttcatag tatttttaga taaatcctta gctacgatgc
      361 aacaacttgt tagcttagat atagaagata tcgccgataa actcacataa agatatcctt
      421 tcgattacat cattgtacat aggatatttc taaaatcttc taaaataaaa acaccagctt
      481 gaatagcagg ttttgtttga ctagcataat ctcgtgtgat tttgtgtaag ccaaataaat
      541 gatgtaaatc agtcaagcaa aaattcactt tgaaaatctc taaatactta taattcgttg
      601 atacttgaca tgtttttcca ttgaatcttt cttgataatc caaaatacaa tcaagtaatt
      661 tcaacgacaa actccatatt ttctcaaaat aaaaaagcac ggggcagttc tcactactgc
      721 ccaaagtggt tgattagagt cggcttctct aactccctat gttgtgctta ttaggcttat
      781 cgcaagggaa cagtttttag ctctgccaag ccacatagtg tgcttactac tatgtgtcca
      841 tgtcaccatg aattgccgaa cggtttaacg agaaagtata gtagattgaa acaagatgtg
      901 aacaaatcga ttaggaaagt caaattaatt tctagaaata ttttaacagt cataacggac
      961 tattccagat tcaatctact atattacttt taggtttatc ccaactcaat tatgacatct
     1021 ttttttcaaa agtcaatata tctcactctt ttcaacgaca agaaagaggc tgataatcga
     1081 ccaacccctg tttttagata cagttcaagt ccaaactatt ctttatagaa aagtccgata
     1141 aattcgagca atagttaaca tacttacaaa tataactccc aaaatagata acactatttt
     1201 cacaaaactc agttccgaac ctatgacata tatatgaaaa agaggggcta gtcctacaca
     1261 tatatacaat aagtagccaa caagttttat ctcaccaatt cctgcaaaaa aatgtttcat
     1321 gtaacgattc tccatttact ccattaaatc agttttattt tagactatca taaaacaatc
     1381 acctcttcaa taaaaaccat tggcgaaata ctattctgaa gcattgatag ctcagatttc
     1441 tcagaataga gctgtcctaa ctatcgagca gctcaaatac atatatatga gcaattctaa
     1501 gtttagaatt gctataaaat aaatgttttc aggctattct aagtctttga ctgcttaaaa
     1561 ttttacattc tgaaggattc taaacctaga atagctcaaa atcacgagaa ctaaggtatt
     1621 cgaaagttca gagtaataca atccccatag gaattctcca ttcttattaa gcatgattaa
     1681 aatgtaatcc taacaagtga tcctcgactg tgtttgtagc acttagttac ctagataaga
     1741 ctatttccct ttatcatatc tgattttaag ccgttctaag atttaaccta tgtttctatt
     1801 acttgctatt tttaaataat tcgtattcct ttgctttgat aaatggaact gaaaaattag
     1861 aaaaaagaag taaaaccgaa aacaaatagc ctgctttttg aatcactaaa agatatccta
     1921 aaaataagta agctataaca tccaatgcga aaagaaaaaa tattctcctc ttcattaaag
     1981 tacttgtgtc aaataatctg atgaataaaa attttatcgt ggtatctaca caaattttta
     2041 tcaaaaagat aagagtcagt acatgattat caactgtacc ataaagaatg gatggaaata
     2101 tagttaatat aaaactagaa atctctaaat attttatcca aggagattga gacaccttgc
     2161 ttctgaactg actaattttc ttatattcgt tagtcaattt agtatcaaaa tctttcccaa
     2221 ttaaatgaaa gattgctaac tctaggataa aaacacttat taatacggta taagtcaaaa
     2281 aactttctgg gaaaaattta ttgattaaaa tggggaaact gattaacaga atcgaattta
     2341 taactagaca gatagatact attttatttt tcacagaata tagaggtagt gatactattg
     2401 agtagataaa agctaaaaaa ataagcaaaa aatactccgt atcatttata atcgccctga
     2461 atgataaaaa tatatacacc caacacacga tgatgtgtat ttttcgaatc ttatctacat
     2521 tactcatctt actgttgcag atatgaatcc atcccaagga taagggttcc cgttaatatc
     2581 acaacctcta ttaagaacac catatccaat acagtaagct attttccctg ctgctgtagc
     2641 caatacacct gctgctgcac caataagcca gcctccaaga cctccaacct taatatagtt
     2701 tattagtttt ttggttaaaa ctgcagctcc agctaatgct ataaaagttc ctgaactcat
     2761 agctaaagct gcgcaaattc cttgacaagc acgcttgctt aaataagctc ccccatcaag
     2821 atacatcatt tcttcttcat caatcacaac ataattattt ggtaatacaa gttccatttg
     2881 ttttctcctc cttagttgaa attgtttcat ttgttttaca aataggacga acttaaacta
     2941 tctttttatt actcagtaat aatttccgag atttcatttt atgatactct ctattcatac
     3001 agaaatcaaa attttgcctt aaccaacttg tataatagaa aaaatctaat tgattgattc
     3061 tgatgaggtg tatcctaatt ttatcaacct tttcttgcca gttgttattg ttactaatag
     3121 aaatctcata cagcagtaac tcgacaagac ctgtacacag aagggtgtta tgagaatctt
     3181 caattttact cagaatatcc tcaaagagtt cactatccgt taaaaaggta gattgattca
     3241 tcgcatcata cagctgaaga gacattaagt cagaataact tagctctgat ttttgtattt
     3301 tatcctttaa cgttttcgtc aaatcgcttt caaacgaatc ttctttttcc catttatttt
     3361 gattgaaaag aaattccgtc ttattaaaaa cgagatgatt gatatccatt atattccaaa
     3421 aaaatattgt agtaagcata atgatgacaa aa
//
LOCUS       DAVHIZ010000098         3437 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.100, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000098 DAVHIZ010000000
VERSION     DAVHIZ010000098.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3437)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.100"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..900)
                     /gene="phtA"
                     /locus_tag="VVO18_001967"
     CDS             complement(<1..900)
                     /gene="phtA"
                     /locus_tag="VVO18_001967"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700436.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtA"
                     /protein_id="HEU5587049.1"
                     /translation="MKINKKYLVGSAAALILSVCSYELGLYQARTVKENNRVSYIDGK
                     QATQKTENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIFSEE
                     LLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQKQEHS
                     QHREGGTSTNDGAVAFARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKN
                     ELSASELAAAEAFLSGRENLSNLRTYRRQNSDNTPRTNWVPSVSNPGTTNTNTSNNSN
                     TNSQASQSNDIDSLLKQLYKLPLS"
     gene            complement(1153..2886)
                     /gene="ptsP"
                     /locus_tag="VVO18_001968"
     CDS             complement(1153..2886)
                     /gene="ptsP"
                     /locus_tag="VVO18_001968"
                     /EC_number="2.7.3.9"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate--protein phosphotransferase"
                     /protein_id="HEU5587050.1"
                     /translation="MTEMLKGIAASDGVAVAKAYLLVQPDLSFETITVEDTNAEEARL
                     DAALQASQDELSVIREKAVGTLGEEAAQVFDAHLMVLADPEMISQIKETIRAKKVNAE
                     AGLKEVTDMFITIFEGMEDNPYMQERAADIRDVTKRVLANLLGKKLPNPASINEEVIV
                     IAHDLTPSDTAQLDKNFVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNNITEIVKDGD
                     ILAVNGITGEVIINPTDEQAAEFKAAGEAYAKQKAEWALLKDAQTVTADGKHFELAAN
                     IGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVR
                     TMDIGGDKELPYFDMPHEMNPFLGFRALRISISETGDAMFRTQIRALLRASVHGQLRI
                     MFPMVALLKEFRAAKAVFDEEKANLLAEGVAVADNIQVGIMIEIPAAAMLADQFAKEV
                     DFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLINNVIKAAHAEGKWAGMCGE
                     MAGDQRAVPLLVGMGLDEFSMSATSVLRTRSLMKKLDTAKMEEYANRALTECSTMEEV
                     LELQKEYVNFD"
     gene            complement(2892..3155)
                     /locus_tag="VVO18_001969"
     CDS             complement(2892..3155)
                     /locus_tag="VVO18_001969"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019775469.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphocarrier protein HPr"
                     /protein_id="HEU5587051.1"
                     /translation="MASKDFHVVAETGIHARPATLLVQTASKFASDITLEYKGKSVNL
                     KSIMGVMSLGVGQGADVTISAEGADADDAIAAISETMEKEGLA"
BASE COUNT          910 a          740 c          645 g         1142 t
ORIGIN      
        1 actcaaaggc agtttgtaga gctgtttcaa gagactatca atgtcattac tttgacttgc
       61 ttgactgtta gtgttgctgt tgttgcttgt gttagtattt gtagttcctg gattgcttac
      121 agaaggtacc cagtttgttc ttggagtgtt atcgctattt tgtcggcgat aggttcttaa
      181 atttgacaga ttttcccgac cagataggaa ggcttctgca gcagccaact cgctagctga
      241 taactcattc ttaggaatgt aatggtaatg atctccatga ggaacgatat aagcatcacc
      301 agtgtcctca atgatatcag atgcattgaa gatataccca tcatctgtgg tgtagcgtcc
      361 ctgtgaacgt gcaaaggcta ccgcaccatc gtttgttgaa gtccctcctt cacgatgctg
      421 actatgttct tgtttttgtc gattgatttc ctcttttgta cggacgttat ccgcgtgggc
      481 agcatcctta aggtaaacat agtattttcc atctaccttg ataacatatc cacccttgac
      541 ctcattaaca atatcctcat cttttagctt atagtttgga tctttcatga gtaattcttc
      601 actgaaaatc gcatcataag gaaccttccc attgtaataa tgatagtggt cgccatgtga
      661 agtgacatag ccttggtctg ttatcttgat gacgatttgc tcagcattga ttccttcacg
      721 cttgctaacc tcatcaggag tcaagttctc cgttttttgc gtcgcttgtt ttccatctat
      781 ataggaaaca cgattatttt ccttaaccgt tctagcttga tacagtccca actcgtaaga
      841 acaaacactt aaaatcaaag ctgccgcaga accaacaagg tatttcttat taattttcat
      901 cgaaactctc tttctatttg atatttctag ttgcaattca tttctaaatt gcagaaactc
      961 ctctctatta cttaactggt taatagttta ctcctaaatc tccaacttgt caagaatttt
     1021 atgaaccatt taagtatttt ttgttctgac cactactttt tcaaggttgg actttctata
     1081 agaaagattt tcttgaaaat ttttttaaaa tatcaaaaaa atccctgtaa ctgagttgca
     1141 gggacttttc gattaatcaa aattaacgta ttctttttga agttcaagaa cttcttccat
     1201 tgttgagcat tctgtaaggg cacggtttgc gtactcttcc atcttagctg tgtcgagttt
     1261 cttcatcaag ctgcgtgtac gaagtacaga tgttgctgac atagagaact catccaagcc
     1321 cattccgaca agaagtggaa cagctcgttg gtcaccagcc atctcaccac acataccagc
     1381 ccatttacct tcagcgtgag ctgctttgat cacattgtta atcaagcgta ggattgatgg
     1441 gttgtatggt tggtaaaggt atgaaacttg ttcgttcata cggtctgctg ccattgtata
     1501 ttggatcaag tcgtttgtac caattgagaa gaagtcaact tctttagcaa attggtctgc
     1561 aagcatagcc gctgcaggaa tctcgatcat gataccaact tggatgttat ccgcaactgc
     1621 aacaccttca gcaagaaggt ttgctttttc ttcatcaaag actgctttcg ctgcacggaa
     1681 ttctttcaag agcgcaacca ttgggaacat gatacgcaat tgaccgtgaa cagacgcacg
     1741 aagaagagca cggatttgtg tgcggaacat agcatctcca gtctcagaga tagagatacg
     1801 aagagcacgg aatccaagga atgggttcat ttcgtgaggc atatcgaagt aaggaagttc
     1861 cttatctcca ccgatatcca ttgtacgaac gacaacaggt ttaccgttca ttccttcaag
     1921 aacagccttg tatgcttcat actgctcatc ttcagttggg aagtcttgag aatccatgta
     1981 caagaactct gtacggtaaa gtccaacagc ttctgcaccg ttgttgttaa caccttcaac
     2041 gtcttttgga gtaccaatat tggcagccaa ctcgaagtgt ttaccgtcag cagtcactgt
     2101 ttgagcatct ttcaaaagtg cccattcagc tttttgtttc gcataggctt caccagctgc
     2161 tttaaattct gccgcttgtt catctgttgg gttgataatc acttctccag tgatcccgtt
     2221 aacagcaagg atgtcaccgt ctttaacgat ttcagtgatg ttgtttgtac ctaatacagc
     2281 agcaatttca agtgtacgtg ccatgatagc tgagtggctt gtacgtccac cgatgttggt
     2341 tacaaaagct tttacaaagt ttttgtccaa ttgagctgta tctgaaggag tcaagtcatg
     2401 cgcaatcaca atcacttctt cattgataga agctgggttt ggcaattttt taccaagaag
     2461 gtttgccaat acacgttttg tcacgtcgcg gatatccgct gcgcgttctt gcatgtatgg
     2521 gttgtcttcc atgccttcaa agatagtgat aaacatatct gtaacttctt tcagacctgc
     2581 ttctgcattc actttcttcg cacggatagt ttccttgatt tggctgatca tttctgggtc
     2641 agcaagaacc attaagtgag catcaaaaac ttgagctgct tcttcaccga gcgtacctac
     2701 tgctttctcg cgaataacag aaagctcgtc ttgtgatgcc tgtagagcgg catcaaggcg
     2761 agcttcttct gcgtttgtat cttcgactgt aatagtctca aatgacaaat ccggctgaac
     2821 gagtagatat gcttttgcaa ctgcaacacc gtcagatgct gcgattcctt taagcatttc
     2881 tgtcatttcc cttatgccaa tccttctttt tccattgttt ctgagattgc agcgatagcg
     2941 tcatctgcat ctgcaccttc agctgagata gttacgtcag caccttggcc aacaccaaga
     3001 ctcataacac ccataattga tttaaggtta actgatttac ctttgtactc aagagtgata
     3061 tctgaagcaa atttgctagc agtttgtacc aacaatgttg ctggacgtgc gtgaatacct
     3121 gtttctgcca ctacgtggaa atctttagaa gccatagttt gactctcctt ttgttctttc
     3181 tttttttgag ttatatgtga taacccttac aatttagtat tataccatct tctaggattt
     3241 ttttcaagca ttttctggat tttccttcaa tttcctttca gataacttgc tgaaaatctt
     3301 ctatcctaga taacaaaaca caggatatag tttctttaaa aacaatttat aggataatca
     3361 ttgctatttc acaatacaaa cactatatat tgtgtttata tataaaaaca acaaaagaac
     3421 accactatat ttagttc
//
LOCUS       DAVHIZ010000099         3432 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.101, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000099 DAVHIZ010000000
VERSION     DAVHIZ010000099.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3432)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3432)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3432
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.101"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..182
                     /locus_tag="VVO18_001970"
     CDS             <1..182
                     /locus_tag="VVO18_001970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007517591.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587052.1"
                     /translation="LFVESLFWIYQLDNGIIGLLPIFQYMVNSNPYALIYWLTLLSII
                     IPLTVFSVHRNWRRV"
     gene            192..890
                     /locus_tag="VVO18_001971"
     CDS             192..890
                     /locus_tag="VVO18_001971"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000517353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587053.1"
                     /translation="MGKLSSHMWRLNQIIYTKYFWGYVLFWILICLGLWYWLEGNDRL
                     VIEILKGPNLSQNSFLVLSIWLLHWFIIHTFFLAVVYRRRASDFFMEVIRFSSIKLWI
                     RYQIWTCFLYGLILIMVKVLVIQFMLQLPNWDIGVLFIVDSLNACVLVLFCFMLYALG
                     ANVQMNFACVSFFLLMIVFGGLFVGNRTNYLFYILNRGNGDIGRDLFLQLLFLVFLFK
                     SIFYFTRQKRRFIE"
     gene            887..1534
                     /locus_tag="VVO18_001972"
     CDS             887..1534
                     /locus_tag="VVO18_001972"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001002414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587054.1"
                     /translation="MNEIIILKNIELKLKKTCVFQNLNFSCKQGEIIGITGANGSGKS
                     VLFKLIAGLYSPSYGEVLINGENIVPERKIPANLGALIEEPGFINYYSGFKNLQYLAS
                     IRGVVGNQEINDTLKIVGLYEQKDQKVKTYSLGMRKKLGIAQAIMENPSILLLDEPMN
                     ALDKSSVENMRTLFRKLSSEKGTTILIASHSEEDIRILCDKVYAIEDKVCTLCSD"
     gene            complement(1614..2479)
                     /locus_tag="VVO18_001973"
                     /pseudo
     CDS             complement(1614..2479)
                     /locus_tag="VVO18_001973"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000765255.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine ABC transporter substrate-binding
                     protein"
     gene            complement(2491..3248)
                     /locus_tag="VVO18_001974"
                     /pseudo
     CDS             complement(2491..3248)
                     /locus_tag="VVO18_001974"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012000401.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter ATP-binding protein"
     gene            complement(3249..>3432)
                     /locus_tag="VVO18_001975"
     CDS             complement(3249..>3432)
                     /locus_tag="VVO18_001975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="glutamine ABC transporter permease"
                     /protein_id="HEU5587055.1"
                     /translation="LVVLIGVVEVTKVGQQIIDSNRLTIPTASFWIYGTILVLYFAVC
                     YPISKLSTHLEKHWRN"
BASE COUNT          999 a          542 c          725 g         1166 t
ORIGIN      
        1 ttttatttgt agaatcctta ttctggattt atcagttgga caatgggata attggattat
       61 tgccaatttt tcagtatatg gtaaattcca atccgtatgc attgatttat tggcttacat
      121 tactatctat cataattcca ttgactgtat tttctgttca tagaaactgg aggagagtgt
      181 aaaagttgga aatgggaaag ttaagtagtc acatgtggag gttgaatcag ataatctata
      241 ccaagtactt ttggggttat gttctttttt ggatattgat ttgtttagga ttatggtatt
      301 ggttagaagg aaatgataga cttgttatag aaattttaaa agggcctaat ctgagtcaaa
      361 actctttttt agtcttatct atatggttgc ttcattggtt tattattcat acattttttc
      421 tagcagttgt atatcgtaga agagcatccg atttctttat ggaagtgatt cgattttctt
      481 ctattaagct ctggattagg tatcagattt ggacctgttt tctttatgga ctcattttaa
      541 tcatggtaaa agttctagtg attcaattta tgttacagtt accaaactgg gatataggag
      601 ttttgtttat agttgattct ttgaatgctt gtgtgttagt cttgttttgc tttatgttat
      661 acgcactagg agcgaatgta caaatgaact ttgcttgcgt tagtttcttt ttactcatga
      721 ttgtgtttgg tggtctattt gtaggaaatc gaactaatta tctattttat attttgaatc
      781 gagggaatgg agatatagga cgagatttat ttcttcagtt gctattttta gtctttcttt
      841 ttaaaagtat tttctatttc actcgtcaaa agaggaggtt tatagaatga atgaaataat
      901 catattaaaa aatattgagt tgaaattaaa aaaaacatgt gtttttcaaa accttaattt
      961 tagttgtaaa cagggggaaa ttataggaat tactggtgcg aatggctcag ggaaaagtgt
     1021 attgtttaaa ttaatagctg gtttatatag tccgtcttat ggagaagtgt taatcaatgg
     1081 ggaaaatatt gttcctgaga gaaaaattcc agctaatttg ggagctttga ttgaagaacc
     1141 tggttttata aattattata gtggctttaa gaatttacaa tatttggcaa gcatacgagg
     1201 agtagttggt aatcaggaaa tcaatgatac actgaaaata gttggtctat atgagcaaaa
     1261 agaccagaaa gttaaaactt attcgctagg tatgaggaaa aagctaggga ttgctcaagc
     1321 aattatggag aatccctcta ttcttttact agatgaacct atgaatgcct tggataaatc
     1381 aagtgtagaa aatatgagaa cattgtttag aaagctctct agtgaaaaag ggacaacaat
     1441 tttgattgct agtcatagtg aagaggatat tcgtatctta tgtgataaag tatatgcaat
     1501 agaagataaa gtatgtacac tgtgttcaga ttgaacatct tagatagact caggatgtta
     1561 taggtaaaat cttaaaaagg gattggagct taaaatccag tcccttttaa gagttaatgg
     1621 ccaccttcaa caaccaggtc atctgcttta gcagcgtcac cgtaggttgg gtgaagtgtt
     1681 ttttcatagg ccttgtggaa gaagttttcc ttgcctaatt tttcaatatc tttattgatg
     1741 aagtctagca attcttggtt gcctttttga actgctgccg caatggtatc gggatcaccg
     1801 agggaagtaa ttcctacttc aaatccttta ttttcaagcg cccaagctag aacttccgta
     1861 ttgtcagttg aaaaggcatc tccacgtccg tcaagaagag cttggtaaga gtcactgtat
     1921 tggtcgtatt tttggagttt gatttctgga tgattctttt caaaataagt ctcagcagtc
     1981 gttccttttg tgacaattaa ggttttacct tcaagttgtt tgacgtctgt aatgagacca
     2041 gtcttaggtg atacgacacc cagagaaact ttcatatatg gaagggcaaa atcaacttgt
     2101 ttcttacgtt cgtcagttac tgtaaagtta gcaagagtaa tatctacctt gtttgaaatc
     2161 aagtattccg cacggttgtc agcatcgact gaaatgtatt taaccttgac accaaggtct
     2221 tgagctagtt ggttccctag ttcaatatcg tagcgtagcc ttggtaagaa ccatcattgt
     2281 caacgtagcc aaacggtttt ttatctccaa acacggcgat tcgcagttca ccgctttttt
     2341 tgatttcatc gatagtgcga gctttggcag ttgtttttcc agaggatgaa ccagcgtttc
     2401 cacctgagct acaagcagtg ataaagataa gggcaaaggc aagtgctaaa acagttaaga
     2461 gtggtttgaa tagtttcata agaatctcct ttatagatat gagccgaatt ggctaaagtc
     2521 aaagacgttt aaaaattcct gggctcgttt ggtttgcgga ttggtaaaga aggcttgagc
     2581 tgttccttct tcagcgattt tcccttggtc gaggaagata atctggtcag caatggcttg
     2641 ggcaaactgc atttcgtggg ttactaaaat catggtacgg ccttcttggg ccaaatcatt
     2701 gataagttcc agcacctcac gcaccatttc tggatccagc gaagcagtca cctcgtcaaa
     2761 aaggatgatt tctggatgca ttaggagggc acggacaatt gcaacacgtt gcttctgtcc
     2821 accagataat tgacgggcaa agctatgttg tttatccagc aaaccgacac gatctagtaa
     2881 ttgcaaagct tcttccgtta cttctttctt gtcccttcct tgagctttga tagggcctag
     2941 gatgaggttt tgtaagacat ccagatgggg aaagagttca taactttgaa agaccatgcc
     3001 aatcttttgg cgaactaggt gaaaatcttt tttattttca acgatagact gaccatccag
     3061 aagaatatct ccaccttgaa tactttctaa gccgttgagg caacgaagga gggtactttt
     3121 cccacaacca gagggcccta ggatgacaac aacttccctt ttttgatttc tagagaaagt
     3181 ccttggagga tgggattgtc tccgaaggat ttttttagtt ccttgatttc taagatagtt
     3241 tcagacattt agtttctcca atgtttttct aagtgagtgg atagtttgga aatagggtag
     3301 caaactgcga aatataagac tagaatggtt ccataaatcc aaaatgaagc agttgggatg
     3361 gtcaggcgat tgctatcgat gatttgttgt ccaactttgg tcacttccac aaccccaatc
     3421 aaaacaacta at
//
LOCUS       DAVHIZ010000100         3363 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.102, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000100 DAVHIZ010000000
VERSION     DAVHIZ010000100.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3363)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3363)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3363
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.102"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(249..1739)
                     /gene="lysS"
                     /locus_tag="VVO18_001976"
     CDS             complement(249..1739)
                     /gene="lysS"
                     /locus_tag="VVO18_001976"
                     /EC_number="6.1.1.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003055423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lysine--tRNA ligase"
                     /protein_id="HEU5587056.1"
                     /translation="MSTEHMEELNDQQIVRREKMAALREQGIDPFGKRFERTANSQEL
                     KDKYANLDKEQLHDKNETATIAGRLITKRGKGKVGFAHLQDREGQIQIYVRKDAVGEE
                     NYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
                     YRKRYLDLISNRESFERFVTRSKIISEIRRYLDQKGFLEVETPVLHNEAGGAAARPFI
                     THHNAQNIDMVLRIATELHLKRLIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQ
                     AYADFQDIMDLTEGIIQHAAKSVKGDGPVNYQGTEIKINELFKRVHMVDAIREITGVD
                     FWQDMTLEEAKAIAAEKKVPVEKHYTEVGHIINAFFEEFVEETLIQPTFVYGHPVAVS
                     PLAKKNPEDQRFTDRFELFIMTKEYGNAFTELNDPIDQLSRFEAQAKAKELGDDEATG
                     IDYDYIEALEYGMPPTGGLGIGIDRLCMLLTDTTTIRDVLLFPTMK"
     gene            complement(1867..2013)
                     /locus_tag="VVO18_001977"
     CDS             complement(1867..2013)
                     /locus_tag="VVO18_001977"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120724.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactate oxidase"
                     /protein_id="HEU5587057.1"
                     /translation="MSYKTSNAEGHVDFINTYDLEPMAQQVIPKAAFGYIASGAGDTF
                     TSFQ"
     gene            2228..2908
                     /locus_tag="VVO18_001978"
     CDS             2228..2908
                     /locus_tag="VVO18_001978"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000384089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5587058.1"
                     /translation="MDWSIVEQYLPLYQKAFFLTLHIAVWGILGSFLLGLIVSIIRHY
                     RIPVLAQVATAYIELSRNTPLLIQLFFLYFGLPRIGIVLSSEVCATLGLVFLGGSYMA
                     ESFRSGLEAISQTQQEIGLAIGLTPLQVFRYVVLPQATAVALPSFSANIIFLIKETSV
                     FSAVALADLMYVAKDLIGLYYETDIALAMLVVAYLIMLLPISLVFSWIERRLRHAGFG
                     NPSTLSRK"
     gene            2868..>3363
                     /locus_tag="VVO18_001979"
     CDS             2868..>3363
                     /locus_tag="VVO18_001979"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001154125.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="amino acid ABC transporter permease"
                     /protein_id="HEU5587059.1"
                     /translation="MQDSGIQVLFQGNNLLRILQGLGVTIGISILSVLLSMMFGTVMG
                     IIMTSHSRIIRFLTRLYLEFIRIMPQLVLLFIVYFGLARNFNINISGETSAIIVFTLW
                     GTAEMGDLVRGAITSLPKHQFESGQALGLTNVQLYYHIIIPQVLRRLLPQAINLVTRM
                     IKTTS"
BASE COUNT          908 a          707 c          680 g         1068 t
ORIGIN      
        1 gtgaatctga acaaatcaat tggggaatcc aagtcaattt ctagtacttt ttgaacagtt
       61 tcagcgtact atcgtaaaat gaaataaaac atgcacaaat tgattaggga atttaaacca
      121 atttctaaca atgtcttaga aatcaaagtg tactatttca acttcaatat actacacttc
      181 attttctcct taaattcagt ctctttttga atcaaaaaat cctctggtaa gagccagagg
      241 ataagaattt atttcattgt tgggaagagc aatacatcac ggatagttgt tgtatcagtg
      301 aggagcatgc agagacggtc gataccgatt cccaaaccac ctgttggtgg cataccgtat
      361 tcaagagctt caatgtagtc atagtcgatt cctgtcgctt catcatcacc aagttctttg
      421 gctttagctt gggcttcaaa acggctaagt tggtcgattg ggtcgttgag ttcagtaaag
      481 gcattaccgt actccttagt catgataaag agctcgaaac ggtcagtaaa gcgttggtct
      541 tcaggatttt tcttagcgag tggagataca gctactggat gtccatagac aaaggttggt
      601 tggattaaag tttcttcaac aaactcttca aagaaggcat tgatgatgtg accaacctca
      661 gtgtagtgtt tctcaactgg aactttcttc tcagcagcga tagctttagc ttcttctaaa
      721 gtcatgtctt gccagaaatc gacaccagta atttctctga tagcatccac catatgaaca
      781 cgcttaaata gttcgttaat cttgatttca gtaccttggt agttgactgg gccatcgccc
      841 ttaactgatt tagcagcgtg ttggataatg ccttccgtca agtccatgat gtcttggaag
      901 tctgcataag cttggtaaac ttcgatagaa gtaaactcag ggttatgagt agcgtccatt
      961 ccttcgttac ggaagatacg gccaatttca tagacacgtt ccataccacc cacgataagg
     1021 cgttttaagt gaagctcagt cgcgatacga agcaccatgt caatgttttg ggcattgtgg
     1081 tgggtgataa atggacgggc agcagcacca ccggcttcat tatgaagaac aggtgtttcc
     1141 acttcaagga atcctttttg gtcaaggtaa cgacggattt cagagatgat ttttgaacga
     1201 gtgacaaagc gttcaaagct ttcacggtta gaaatcaagt caaggtaacg tttacggtaa
     1261 attgtttcaa cgtctgtcaa accatggaat ttctcaggaa gaggacgaag agccttagac
     1321 aagtgtgtga tgtgggttgc cttgatagag agttctccca tatccgtacg catcacttca
     1381 ccttcgacac caaggaagtc accaaggtct gcttttttga agatttcgta gttttcttca
     1441 ccgacagcat ccttacgaac gtagatctga atctggcctt cgcggtcttg aaggtgggca
     1501 aaaccaactt ttcctttacc acgtttggtt atcaagcgtc ctgcgatagt agctgtttcg
     1561 tttttatcgt gtaattgttc tttatcgagg ttggcatatt tatcttttaa ttcttgtgaa
     1621 tttgcagtac gttcaaaacg ttttccgaaa ggatcgattc cttgttcgcg gagcgcagcc
     1681 attttttcac ggcgaacgat ctgctggtca tttagttctt ccatatgttc tgtagacatg
     1741 ggatcctcct agttttactc aaaattgaat acgatgagtc attttttgcg atactcccat
     1801 tttatcataa ataagcaaga aattcacgga taatctttaa aaactaaaaa gaacctgacg
     1861 ctaaaatcac tggaaagaag tgaaagtatc tcccgcccca ctagcgatat agccaaatgc
     1921 tgctttagga ataacttgtt gcgccattgg ctccaaatca taggtattga tgaaatctac
     1981 atgaccttct gcattgcttg ttttgtatga cataaaatgc cctccttgat aagtaagcgt
     2041 ttactttgta tattacaaaa atatcttaac tctttttcaa aacttttcaa atattttgtt
     2101 tggaaatttc agaaatttta tgtctatggt aaaaaatcct tataacggca ataaaaaata
     2161 gatattatcc aaagaagatt ttaagtgcta caataactgt attatttcta gatgggaggt
     2221 tctatttttg gattggtcca ttgttgaaca atatctacca ctatatcaaa aggcattctt
     2281 tctgaccttg catattgcag tttggggaat tttgggatcc tttctgctcg gtttaatcgt
     2341 tagtatcatc cgacattatc gaatccctgt tttggcgcaa gtagcgacag cctacattga
     2401 attgtcacgt aatacgcccc ttttgattca actcttcttt ctctacttcg gtcttccccg
     2461 aatcgggatt gtcctatctt cagaagtctg tgcaacgctt gggcttgtct ttttaggagg
     2521 ctcctatatg gcagaatctt tccgaagtgg gctggaagcc atcagtcaaa cccagcagga
     2581 gattggcctc gctattggtc tgacacctct acaggtcttt cgctatgtgg ttcttccgca
     2641 agcaacagcg gtggcactcc cctcctttag tgccaatatc attttcctta tcaaggaaac
     2701 ctctgttttc tcagcagtgg ctttggccga cctcatgtat gtcgccaagg atttgattgg
     2761 tctctactat gagacagaca ttgcgctagc tatgttggta gttgcttatc tgatcatgct
     2821 gctacccatc tcactggtct ttagctggat agaaaggagg ctccgccatg caggattcgg
     2881 gaatccaagt actctttcaa ggaaataatc tcctgagaat cttacaggga ttgggcgtta
     2941 cgattgggat atccatcctg tctgtcctct tatccatgat gttcggaaca gtcatgggaa
     3001 tcatcatgac ctcccattct agaatcatac gatttttaac acgattgtat ctggaattta
     3061 tccgtatcat gccccagctg gtgctactct tcatcgttta ctttggcttg gctcgaaact
     3121 ttaatatcaa tatctcaggt gagacttcag ctattatcgt ttttaccctc tggggaacag
     3181 ctgaaatggg agacttggta cgtggagcta tcacttctct ccctaaacat cagtttgaaa
     3241 gtggacaggc actcggcttg actaatgttc aactttacta ccacatcatc atcccacaag
     3301 tcttaagaag actgctaccg caggctatca atcttgtcac tcggatgatt aaaaccactt
     3361 cat
//
LOCUS       DAVHIZ010000101         3232 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.103, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000101 DAVHIZ010000000
VERSION     DAVHIZ010000101.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3232)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.103"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            259..360
                     /locus_tag="VVO18_001980"
                     /pseudo
     CDS             259..360
                     /locus_tag="VVO18_001980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000911560.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
     gene            482..2497
                     /locus_tag="VVO18_001981"
     CDS             482..2497
                     /locus_tag="VVO18_001981"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-associated integral membrane family
                     protein"
                     /protein_id="HEU5587060.1"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSYYYPNVVVRDSSPE
                     TTFQHVATRLEKLAEETDSFIAIQHQDPNSEGTPVFSYTTFGNGKLPDGLQEKNLEDA
                     QSSSVETNYFVFDGHLDIHLLREELSQLGLTNMHLTIPSKLSTLMAIFSNGFQLISLL
                     IFILTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLTI
                     LMQKILSLPTQSLMTIGAGLLSYNLILLSISLFFAQLFAVGIKKIHLMQIIKGQVPVR
                     GIISLILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSISREGTS
                     PGFDEQAQRKLRTWYQLMDLAVSEQKAFLSRHQLIDRTLQNGMASSKNFITSTEWHDY
                     SPNGNVLIVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEDHYKSVFED
                     DLTSRMSSQDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQ
                     SILFWIDAVQNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVM
                     LAGAVLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLG
                     FVASVFLQVEIGVAFLVLLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     gene            2499..3131
                     /locus_tag="VVO18_001982"
     CDS             2499..3131
                     /locus_tag="VVO18_001982"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004260353.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587061.1"
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLM
                     NMIGKLEPYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIG
                     QKLSRSEQRLRQKQALEQVGLVYLDLDKRIFELSGGESQRVALAKIILKNPPFILADE
                     PTASIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVFTMDHLK"
BASE COUNT          969 a          580 c          678 g         1005 t
ORIGIN      
        1 aaatttgcga ttttcacaga gaaaggaaga aaaagtatag aaataagtca aatggagatg
       61 tttgataaaa tgctttcata gctaaccaac tgttgaaaat tatgagttac aaaatctaaa
      121 gtatttaaga ttagtttata aaattaggtc tctgcctgta gaaaggaacg tgcagttaga
      181 aaggaggaaa aaataggata ctataattca gactgagatt tctaattaaa atatgtagtt
      241 gcatcatccc ttgccgtttt ggcatttagt ttggctcttc ctgttttggt agcttctcac
      301 cgtggtggcg agtggaccta tggaggctat catgatccaa ataattgggg agcaaattac
      361 atttgatgcg ggatggtaaa gaataattga agaagattct tttatcaata gtttagtaag
      421 cttgttagtt tatagaggtc aggggtattt ctgccctctg ttttagaata aggaatgcac
      481 tatgaaaaaa ttatttatac tcatatccaa cctgcttgct agtttgttct ttgtttgggt
      541 atttaccatt tggactgata catatgtctc ctattattac cccaacgttg ttgtacgtga
      601 ttcttcccct gaaacaactt ttcagcatgt tgctacacgc ttggaaaaac tagcagaaga
      661 aacggatagc tttattgcga ttcaacacca agatcctaac tcagaaggta ctccagtgtt
      721 ttcttatacg acctttggga acggaaagtt gcctgatggg cttcaggaaa aaaatctaga
      781 agatgctcaa agtagtagtg ttgaaacaaa ctattttgta ttcgatggac acctagatat
      841 tcacttgcta agggaggagc taagtcaact tggcttgact aatatgcacc tgacaattcc
      901 atctaaacta tctacgttaa tggctatctt tagtaacgga tttcagttaa tcagtctatt
      961 gattttcatc ttaacctttg gagcactgac tttaattagt caaattagcc aattacggtc
     1021 gtcgggcatt cgcctcattt caggagagaa acggtggtcc atttttctta gaccagttgg
     1081 tgaggatttg aaagggatag ctgttggttt cagtttagct ggcgtgctca ccattcttat
     1141 gcaaaaaatt ctgtcgcttc caacgcaatc cctaatgacc ataggagcag gcttgctcag
     1201 ttataatctc atcttgttgt ctatctccct gtttttcgct caactcttcg cagttgggat
     1261 aaaaaagata cacctgatgc agattataaa agggcaagtg cctgtcagag gaatcattag
     1321 tttgatttta atcggtcaac tattagcgat tattattgta acactgggaa tagggagtag
     1381 cttaaagtat tcccaagcct ggcaacagca tcggattgga caagaggctt ggagccagga
     1441 aaggcaactg attaccctat caatcagccg tgaaggaacg agtcctggtt ttgatgaaca
     1501 agctcaaagg aaactcagaa cttggtatca attgatggat ctggctgttt cagaacaaaa
     1561 ggctttctta tctagacacc agttaattga ccgtactttg caaaatggca tggcttcctc
     1621 caaaaacttt ataacctcta cagaatggca cgattacagc ccgaatggca atgtccttat
     1681 cgtcacaccg caatacttgg agcgtcaaaa cattcctgta gatacaacta ttgagcaaaa
     1741 gatgaatcac cttgatgtag gggagtttgt cttattgctg cctgaacacc tccgttcaga
     1801 ggaagatcat tataaatctg tttttgaaga cgacttaacc agtcgcatgt ctagtcaaga
     1861 tgaacgacag caaatgactg ctacggtagg ttatttagaa tcaggtcagg atcgttttgt
     1921 gtataatacg acccctattt cttaccagca gtttttgaaa gatccaatca tcattgttat
     1981 aacaccccaa tcaactggtc cacagtccat tttgttttgg atagacgcag tacagaacta
     2041 cgttctcttt aatcaattgt ctgatgccca ggagcttatc cagagacaag gcattgaaaa
     2101 ttgggtctca gaaatgcaaa caggttacca caactacatc acattattgg ataatatcca
     2161 gagggaacgt tgggtaatgc tagcaggagc tgtgcttggg attgcaactt caatcttgct
     2221 gtttaacact atgaataggc tctactttga agaatttaga cgtgccattt ttatcaaacg
     2281 cattgcaggt ctcaggttct tagaaatcca tcgcacttat ctctttgctc aactgggtgt
     2341 gtttttactg ggatttgttg ctagtgtatt tcttcaggta gaaataggag ttgctttctt
     2401 agtcttgtta ctctttactg gtctatctct tttacagtta catgtccaaa tgcagaaaga
     2461 aaacaagatg tccatgcttg ttttgaaggg aggttaatat gattgaactt aaacaggtga
     2521 gtaaatcttt tggagaacga gagttatttt cgaatctttc aatgacattt gaggctggaa
     2581 aagtctatgc cttaattggt tcaagtggta gcggaaaaac aaccttgatg aacatgattg
     2641 ggaaattaga accttatgat gggacgattt tttaccgagg taaagacttg gccaattata
     2701 aatcaagtga ttttttccgt cacgaattgg gctacctctt ccagaacttt ggcttaattg
     2761 aaaaccaaag tattgaagaa aaccttaagc taggtctcat tggtcaaaag ttgagtcggt
     2821 cggaacagcg gttgaggcag aagcaggctt tagaacaggt cggcctggtt tatcttgacc
     2881 tagataagcg catctttgag ttatcgggcg gagaatcgca acgggttgcc ttggcaaaaa
     2941 ttatcttaaa gaatccaccc tttattctgg cagatgagcc aacagcttca atagacccag
     3001 caacctctca gttgattatg gagattttgc tatctcttcg agatgataat aggctaatca
     3061 ttatcgcaac acataatccg gcaatttggg agatggctga tgaagtgttc acgatggatc
     3121 atctgaaata aaaatccttg tttttaattg cacgatgagt tactgaaata ttatcatgaa
     3181 tcaagaattg gagttaattt agaattgtac tttattaata ttgaggtaac tt
//
LOCUS       DAVHIZ010000102         3138 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.104, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000102 DAVHIZ010000000
VERSION     DAVHIZ010000102.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3138)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.104"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..167
                     /locus_tag="VVO18_001983"
     CDS             <1..167
                     /locus_tag="VVO18_001983"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001818644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="HEU5587062.1"
                     /translation="VSFAISSKGEKMKVENISYRVDHRILFDNISFDTSSSGVTLITG
                     KNGTGKSTLL"
     gene            complement(533..1843)
                     /locus_tag="VVO18_001984"
     CDS             complement(533..1843)
                     /locus_tag="VVO18_001984"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000581523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLC13 family permease"
                     /protein_id="HEU5587063.1"
                     /translation="MIHLIMISAIALAIGIGYRTKINIGLLAIAFSYLIATTLMGLSP
                     KELLHFWPTSLFFTIFSVSLFYNVATTNGTLDVLAQHILYRTRTHPNALYMILYLMAT
                     LLSALGAGFFTTMAVCCPLAITLCQKADKHPLIGAQAVNWGASGGANLITSSSGIVFQ
                     GLFKQMGWEEQAFSLGNHIFIVSIIYPLIVLLLLSCYSHYSKGRTNSSLTIDQPPLLS
                     KVQRQTTLLMISSMVLVWLFPLLHLIFPNIAWIATYQKTFDIGFVSILMVCLALRLKL
                     GKQEAILAKVPWATIIMLCGMSLLMSLAVKSGLVTLIGHLMTTTIPHFWLPLFFCVIA
                     GVMSLFSSTLSVVAPALFPIIAIISAQNPQIDIHLLTTATVIGALSTNISPFSSAGSL
                     IQLSLPNIEERGLAFKKQIILGVPISLSLGLLTTWILILLASLS"
     gene            2080..2952
                     /locus_tag="VVO18_001985"
     CDS             2080..2952
                     /locus_tag="VVO18_001985"
                     /EC_number="2.4.2.19"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000022746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carboxylating nicotinate-nucleotide
                     diphosphorylase"
                     /protein_id="HEU5587064.1"
                     /translation="MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKV
                     SLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFKDGDRLTSGDLVLEIIGSVRSLL
                     TCERVALNFLQHLSGIASMTAAYVEALGDDCIKVFDTRKTTPNLRLFEKYAVRVGGGY
                     NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGA
                     DIIMLDNMSLEQIEQAITLIAGRSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAK
                     SLDFSMKGLTYLDV"
BASE COUNT          960 a          526 c          712 g          940 t
ORIGIN      
        1 ctgtttcttt tgctattagt tcaaaaggag aaaaaatgaa agtagaaaat atttcgtata
       61 gggtggatca tcgtatattg tttgataata tttcttttga tacttcgagt tcaggcgtga
      121 cattaattac tggtaaaaat ggtacaggaa agtcaacttt actatagtag attgaaacta
      181 gaatagtaca catctacttc taaaatattg ttagaaatcg atttgactat cctgatctat
      241 ttgtcctgtt cttatttcat ttcactatat ctcaaattga gtatgacgaa gtgcgctccc
      301 atgtcctggg aacgcacttt cttcatattt ttcatattct tgaatccatc gataaagact
      361 attgggatga atttttaaag ttgaactaat catttttaca ggatgagatt tacagcagag
      421 agtttgaagg ctttatcaaa ggtttttctt ggcataatga cttttcctcg tttccactta
      481 attttgtgtc tactttatta taccaagtcc acccttaagt tagataataa atctaactta
      541 aggaagctag aaggatgaga atccaggtgg tcaagagtcc caaacttaag ctgatgggga
      601 cacccagaat aatttgcttt ttgaaggcaa ggccacgttc ctctatattg ggaagtgaga
      661 gttgaatgag agaaccagct gatgaaaagg gtgagatatt agtagataga gcgccaataa
      721 cggtggctgt tgtgagtaag tgaatatcaa tctgaggatt ttgagcactg atgatagcaa
      781 tgatgggaaa gagggctgga gctacaacgg atagggtgga actaaagagt gacatcactc
      841 cggctatcac acaaaagaac agaggtaacc agaaatgagg aatggttgtt gtcatgaggt
      901 gccctatcag tgtgactaaa cctgacttga ccgctagaga cattagtaag ctcatgccgc
      961 agagcatgat aattgtagcc cagggaacct tagctaaaat ggcttcttgc ttccctaatt
     1021 tgagccttaa ggcgaggcag accatgagta ttgagacaaa gccaatatca aatgtttttt
     1081 gataagtagc tatccaggcg atgtttggga aaatgagatg caacaaggga aaaagccaaa
     1141 ccaaaaccat gctgctgatc atgagcaagg tggtttgtct ttgaaccttg ctgaggagtg
     1201 gtggttggtc aatagtcaag gatgagtttg ttcttccctt actatagtga ctgtaacagg
     1261 ataataaaag caagacgatg agtgggtaga taatgctgac gataaagata tgattgccaa
     1321 gtgaaaaagc ttgctcttcc catcccattt gcttaaacag gccttgaaag acaatgcctg
     1381 agctactggt tatcaaatta gcccctcctg aagctcccca attgacggct tgagctccaa
     1441 tcaaagggtg tttgtccgct ttttgacaga gggtaatcgc tagaggacag caaacggcca
     1501 tagtagtgaa aaatccagca cctaaagcag acaaaagggt tgccatcagg tataaaatca
     1561 tgtagagggc gttagggtgg gtgcgtgtgc ggtagagaat gtgttgagcc aaaacatcaa
     1621 gagtaccgtt agttgttgca acgttataaa agagagagac gctaaaaatg gtaaaaaaga
     1681 gtgaggttgg ccaaaaatga agaagttctt tggggcttaa tcccatgaga gtggttgcga
     1741 tgaggtaaga aaaagcaata gccagcaggc caatattgat tttggtgcgg taaccaattc
     1801 caatggctag agcaatggcg ctaatcatta ttaaatgaat cattgaattg tcctttcagt
     1861 tagaatatgg aaataggttg gcaattttgg cgctcaaaag accacctgtt tcctattggt
     1921 acttgactat tatacacaaa aaaaatacaa ttgtcttgac aattgtattg acacttgtta
     1981 gaattaaaaa tgaggtattc aggcttgtga tttcctatgg aagttaatag taattgcctc
     2041 tagtgcttac aagtgatatt aaaaatagag gacttagtga tgtcaatcat ttcaactgat
     2101 ttaacccctt ttcaaataga tgatacattg aaagcagcct tgcgagaaga tgttcattcc
     2161 gaagattaca gtaccaatgc catttttgat catcatggcc aagccaaggt gtcgcttttt
     2221 gccaaggaag ctggtgtttt agcgggacta accgtttttc aaagggtttt taccctattt
     2281 gatgccgagg tgaccttcca gaatcctcat caatttaagg atggggatcg tttgactagt
     2341 ggcgatttgg ttttagaaat cataggctcg gtgagaagtc tcttaacatg tgaacgcgtt
     2401 gccttgaatt ttttacaaca tttatcaggg attgcttcga tgacagctgc ttatgtagaa
     2461 gccttaggcg atgattgcat taaggtattt gatactcgaa aaactactcc taatttacgt
     2521 ctttttgaga aatatgccgt gagagttggc ggtggctata atcatcgctt taatttatca
     2581 gatgctatca tgctaaaaga caatcacatt gcggcagtag gtagtgttca gaaggcaatt
     2641 gctcaagcgc gtgcctatgc cccttttgtg aaaatggtcg aggtggaagt ggaaagcctt
     2701 gctgctgccg aagaagctgc ggcggcgggt gctgatatta tcatgttgga taatatgtca
     2761 ttggaacaga ttgaacaggc cattacccta attgcaggac gttctcggat tgaatgttct
     2821 ggaaatattg atatgaccac tattagccgt tttcgtggtt tagcgattga ttacgtctcc
     2881 agtggtagtt taacccatag tgctaagagt cttgattttt ccatgaaggg tttaacctac
     2941 cttgatgtct aagttgtaaa ataaactaac tttttaaagg atgtctttcc tctagaacga
     3001 gttttatgtc agatagttta aacgcctctt caaatatagt aaaatgaacc aaaaatagta
     3061 cacaatgtgg tataatcttc ttatggcata ttcaatagat tttcgtaaaa aagttctctc
     3121 ttattgtgag cgaacagg
//
LOCUS       DAVHIZ010000103         3061 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.105, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000103 DAVHIZ010000000
VERSION     DAVHIZ010000103.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3061)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.105"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            221..1507
                     /locus_tag="VVO18_001986"
     CDS             221..1507
                     /locus_tag="VVO18_001986"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
                     /protein_id="HEU5587065.1"
                     /translation="MTKTLKRPEVLSPAGTLEKLKVAVQYGADAVFIGGQAYGLRSRA
                     GNSTFEQMEEGVQFAAKYGAKVYVAANMVMHEGNEAGAGEWFRKLRDIGIAAVIVSDP
                     ALIMIAATEAPGLEIHLSTQASATNYETLEFWKELGLTRVVLAREVSMEELAEIRKRT
                     DVEIEAFVHGAMCISYSGRCTLSNHMSMRDANRGGCSQSCRWKYDLYDMPFGKERKSL
                     QGEIPEEFSMSAVDMSMIDHIPDMIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVDAY
                     LESPEKFEAIKQDLVDEMWKVAQRELATGFYYGIPSENEQLFGARRKIPEYKFVAEVV
                     SYDDAVQTATIRQRNVINEGDQVEFYGPGFRHFETYIEDLHDAKGNKIDRAPNPMELL
                     TIKVPQPVQSGDMVRALKEGLINFYKEDGTSVTVRA"
     gene            1522..1833
                     /locus_tag="VVO18_001987"
     CDS             1522..1833
                     /locus_tag="VVO18_001987"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587066.1"
                     /translation="MIEAQGFLVDKQTRCIHYHSKLDIIALQCYDCKKYYACYRCHDS
                     LENHPFEPYPLSLIQDKPILCGVCLKLLTYKQYKESLSCLFCFSRFNPGCQNHKERYF
                     K"
     gene            2093..2821
                     /locus_tag="VVO18_001988"
                     /pseudo
     CDS             2093..2821
                     /locus_tag="VVO18_001988"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000169115.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="U32 family peptidase"
BASE COUNT          941 a          534 c          668 g          918 t
ORIGIN      
        1 atttttacga gtcagtatct tgggatactg gtttttactt ttttagactt tttgactact
       61 tgttaaaact ggggtaattt tcgactgttt aacagttatt atgcaaagtc taaaagatta
      121 gaattgtcaa aacaatccgt ctaggcttga ttttatcctt tatttactat aaaatgagaa
      181 ggaaaaatgt caaactttta tattgcaaat aggagaaatc atgacaaaaa cattaaaacg
      241 tcctgaggtt ttatcacctg cagggacttt agagaagcta aaggtagctg ttcagtatgg
      301 agcagatgct gtctttatcg gtggtcaggc ctatggtctt cgtagccgtg cgggaaactc
      361 tactttcgaa cagatggaag aaggcgtgca gtttgcggcc aagtatggtg ccaaggtcta
      421 tgtagcggct aatatggtta tgcacgaagg aaatgaagct ggtgctggtg agtggttccg
      481 taaactgcgt gatatcggga ttgcagcagt tatcgtatct gacccagcct tgattatgat
      541 tgcagcgact gaagcaccag gccttgaaat ccacctttct acccaagcca gtgccactaa
      601 ctatgaaacc cttgagttct ggaaagagct aggcttgact cgtgtcgttt tagcgcgtga
      661 ggtttcaatg gaagaattag ctgagatccg caaacgtaca gatgttgaaa ttgaagcctt
      721 tgtccatgga gctatgtgta tttcatactc tggacgttgt actctttcaa accacatgag
      781 tatgcgtgat gccaaccgtg gtggatgttc tcagtcatgc cgttggaaat acgaccttta
      841 cgatatgcca tttgggaaag aacgtaagag tttgcagggt gagattccag aagaattttc
      901 aatgtcagcc gttgacatgt ctatgattga ccacattcca gatatgattg aaaatggtgt
      961 ggacagtcta aaaatcgaag gacgtatgaa gtctattcac tacgtatcaa cagtaaccaa
     1021 ctgctacaag gcggctgtgg atgcctatct tgaaagtcct gaaaagtttg aagctatcaa
     1081 acaagacttg gtggacgaga tgtggaaggt tgcccaacgt gaattggcaa caggtttcta
     1141 ctacggtata ccatctgaaa atgagcagtt gtttggtgct cgccgtaaaa ttcctgagta
     1201 caagtttgtc gctgaagtgg tttcttatga tgatgcggta caaacagcaa ccattcgtca
     1261 acgaaacgtc attaacgaag gggaccaagt tgagttttat ggtccaggtt tccgtcattt
     1321 tgaaacctat attgaagatt tgcatgatgc caaaggcaat aaaatcgacc gcgctccaaa
     1381 tccaatggaa ctattgacta ttaaagtccc acaacccgtt caatcaggag acatggttcg
     1441 tgcattaaaa gaaggactca tcaattttta taaggaagat ggaaccagcg tcacagttcg
     1501 agcttaagaa aggaaaagga aatgatagag gcacagggtt tcttagtgga taagcaaaca
     1561 agatgcattc attaccatag caagctggat attattgctt tacaatgcta tgattgtaaa
     1621 aagtattatg cttgttatcg gtgtcatgat tcattagaaa atcacccttt tgagccttat
     1681 cccttatctt tgatacagga taagcctatt ttatgtggtg tttgtctaaa actattaaca
     1741 tataagcaat ataaagaaag cttaagttgc ctcttttgtt tttctcgctt taatccaggt
     1801 tgccaaaatc ataaggaacg ctattttaaa tagcaaatca tctagttttg aagtaggaga
     1861 aaactcaatt ccaagagaaa atgaagtaaa tcttcccaca ataaaacgca taatatcaag
     1921 attgttcaat acctgatact atgcgttttt aagattttaa agactttttt cctagcccct
     1981 ttttacttta tctggtattt tgactacttg ttaaaactgg ggtaattttc gactgtttaa
     2041 cagttattat gcaaagtcta aaaggttaga attgtcaaaa caatccgtct agagtatgcg
     2101 tgatgccaac cgtggtggat gttctcagtc atgccgttgg aagtacgacc tttacgatat
     2161 gccatttggg aaagaacgta agagtttgca gggtgagatt ccagaagaat tttcaatgtc
     2221 agccgttgat atgtctatga ttgaccatat ctcagatatg attgaaaatg gtgtggacag
     2281 tctaaaaatc gaaggacgta tggagtctat tcactatgta tcaacagtaa ccaactgtta
     2341 caaggcggct gtggatgcct atcttgaaag tcctgaaaag tttgaagcta tcaaacaaga
     2401 cttggtggac gagatgtgga aggttgccca acgtgaactg gctacaggat tttactatgg
     2461 tacaccatct gaaaatgagc agttgtttgg tgctcgtcgt aaaatccctg agtacaagtt
     2521 tgtcgctgaa gtggtttctt atgatgatgc ggcacaaaca gcaactattc gtcaacgaaa
     2581 cgtcattaac gaaggggacc aagttgagtt ttatggtcca ggtttccgtc attttgaaac
     2641 ctatattgaa gatttgcatg atgccaaagg caataaaatc gaccgcgctc caaatccaat
     2701 ggaactattg actattaaag tcccacaacc tgttcaagct ggagacatgg ttcgagctct
     2761 taaagagggg cttatcaatc tttataagga agatggaacc agcgtcacag ttcgtgctta
     2821 atgtagttgt ttagttttaa aaaattatgc aaagctccat atacaacact taaacgagat
     2881 taaagaatgg cgaaatccct tgatgcgcaa gagattagct gtcctttttt attttttaag
     2941 tgataaagtc ggagcttagg tattaaagcc tatcaaatta aacaaagaag cgatgtctta
     3001 gatattttga aaaaaattaa taagcagaaa actctctatt attttgttgt agagagtttt
     3061 t
//
LOCUS       DAVHIZ010000104         2882 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.106, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000104 DAVHIZ010000000
VERSION     DAVHIZ010000104.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2882)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.106"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            509..694
                     /locus_tag="VVO18_001989"
                     /pseudo
     CDS             509..694
                     /locus_tag="VVO18_001989"
                     /inference="COORDINATES: protein motif:HMM:NF024172.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            1291..1575
                     /locus_tag="VVO18_001990"
     CDS             1291..1575
                     /locus_tag="VVO18_001990"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002923859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587067.1"
                     /translation="MVWYDYMIQASKQSQFNASHWFRYLRKVIFEDYSYLTNQDVEKL
                     LDSKELTRFQKISLKYAFQEHTPTHKYVISLNKPAKLTNVQKLMEKYKHG"
     gene            1568..1717
                     /locus_tag="VVO18_001991"
     CDS             1568..1717
                     /locus_tag="VVO18_001991"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000359822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587068.1"
                     /translation="MDKMKPVFQALNKELIQENLTLTIICVDGYVLEYHGLRATQDVD
                     AFMAL"
     gene            1832..2882
                     /locus_tag="VVO18_001992"
                     /pseudo
     CDS             1832..2882
                     /locus_tag="VVO18_001992"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing C-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
BASE COUNT         1020 a          553 c          436 g          873 t
ORIGIN      
        1 attaaaataa cttttcttct agctgcattt tattattata aaaacattca tcataacccc
       61 cagaacttaa ataacaattt ttattcaaga tacatactcc tagaataaac tttatatgaa
      121 attctcattt ttgtttttac aattctcctt agttaaatct tgtttaatat atgttttaca
      181 tatagtattt agcgccacat agtactgaac tctctccaaa aacggttatg cctctttgaa
      241 tagggcgtta tcacaagaaa agcatctcca cgtttcaact tcatatggct caaaaacaat
      301 caattgatgc taaaacctgt acctagatgt ttcggttcat aaaaccatga aactgtaaaa
      361 gtggatgaaa ttgatagcga tagtcaaatc aagaggcatc ataactctaa aaagtcacaa
      421 tatataagtt catcctcgga aaaatatcat tctaattgtt gaaatgccta catgaaaaga
      481 aacgtcaaat actcatgaaa caacgaatac aggtatcaaa actatgacaa aacaagtccc
      541 taaatttact aaagacactg ctcaacttta cacctgtaaa tggttgttgt ataataaagt
      601 tacaaagatg tacgaccaca ctgttgtaaa tcatagtgtt cgcgaatata ttactgatag
      661 catttctaca aatacaattg aaaaggctgg ataggcttta aacgaaatat gtcagtgttt
      721 tggcattcct agccttcata tcatttaaag aattgtatag acaaaatttt tcccaataca
      781 gacactcgta acaactgctt catttttcta ccaacatatt taggaacagg ataagataca
      841 agaggattaa tccatagatc agttctatac caatctaaga caaataagct aaaaaaacga
      901 ttgataataa gcaaatagat tccaaatttt ctctatctgc tcattttaat aaacaatact
      961 agtgtaacta tccttccagt cagaagcttg tcaaatcaca ccgaaaattc ttctaaaatt
     1021 tatctcgtta ggcaatcaag caaaaactcg acgatagtac aaacattatc atacagaatt
     1081 gacttcctaa attatatact ttagtaaggt tttcggataa gaaaaaaggt tcattttaca
     1141 tttctaaaca ttcttttcta agatgaaaaa cagaattttt cgattgtgat ttaaagcaac
     1201 aagaagattt tcagtatcat cctatagata cgagctaatt aagaaaaact acatttttga
     1261 atataaacta aattttatag gaggaaaaca atggtttggt acgattatat gatacaggca
     1321 tccaaacaat cacaattcaa cgcaagccat tggtttcgct atttgcgaaa agttattttt
     1381 gaagactatt cttatttaac aaaccaagat gtagaaaagt tgctagactc caaagaacta
     1441 acccgttttc aaaaaattag cttgaagtat gcctttcaag agcatactcc aactcataaa
     1501 tatgtgattt cattaaataa acctgctaag ttaaccaatg ttcaaaaatt gatggagaaa
     1561 tacaaacatg gataaaatga aaccggtctt ccaagcccta aataaggaat taattcagga
     1621 aaatctgact ttaacaatta tctgtgtcga tggttatgtc ttagaatatc atggtttacg
     1681 tgccacacaa gatgttgatg cttttatggc tctataatat ttgtagtggg taaccccccc
     1741 tatggatatt atggagccta ttttgtgtag aaaaaaagtc ccatatgacc tataatgaaa
     1801 agcgacaaaa caactcatta gaaagaatca tatggaacaa ttacatttta tcacaaaatt
     1861 actagacatt aaagacccta atatccagat ttcagacatc atcaataaag atacacacaa
     1921 ggaaatcatc gccaaactgg actacgacgc cccatcttgc cctgagtgcg gaaaccaatt
     1981 gaagaaatat gactttcaaa aaccgtctaa gatcccttac ctcgaaacaa ctggtatgcc
     2041 ttctagaatt ctccttagaa aacgccgttt caagtgctat cactgttcaa aaatgatggt
     2101 cgctgaaact tctatcgtca agaaaaatca ccaaatccct cgtatcatca accaaaaaat
     2161 tgcgcaaaag ttgattgaga agatttctat gaccgatatt gctcatcagc tggccatttc
     2221 aacttcaact gtcattcgca agctcaatga ttctcacttt gagcatgatt tttcgcgtct
     2281 tcctgagatt atgtcctggg acgttgaaac agtccgggga gtgactgttt caatcgggag
     2341 atggagatga gctttattgc gcaagatttt gaaaagctcg atatcatcac tgttcttgaa
     2401 ggtagaacac aagctgtcat ccgagatcac tttcttaaat atgatagagc cgtccgatgt
     2461 cgcgtcaaaa tcattactat ggatatgttt agcccttact atgacttggc taaacagctt
     2521 cgctttcaaa tttctaggct caggctgaaa cagtctccca gactgtttca ctcccgaatg
     2581 ctaaaatcgt tcttgatcgc tttcacattg tgcaacatct tagccgtgct atgagtcgtg
     2641 tgcgtgttca aatcatgaat cagtttcatc gaaaatccca tgaatacaag gctatcaagc
     2701 gctactggaa gctcatacaa caggatagcc gtaaactgag tgataagcga ttttatcgtc
     2761 ctacttttcg tatgcattta accaataaag agattttaaa caagcttttg agttattcac
     2821 aagacttgaa acaccactat cagctctatc agctcttgct ttttcacttc cagaataagg
     2881 aa
//
LOCUS       DAVHIZ010000105         2823 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.107, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000105 DAVHIZ010000000
VERSION     DAVHIZ010000105.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2823)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.107"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..243
                     /locus_tag="VVO18_001993"
     CDS             <1..243
                     /locus_tag="VVO18_001993"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756162.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU5587069.1"
                     /translation="QKFIIHVLRNNNYSRVISGSAQPQLPITKLKKILLPLPPLALQN
                     EFADFVVQIDKSQLAIQKSLEELETLKKSLMQEYFG"
     gene            303..539
                     /locus_tag="VVO18_001994"
     CDS             303..539
                     /locus_tag="VVO18_001994"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000260605.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AbrB family transcriptional regulator"
                     /protein_id="HEU5587070.1"
                     /translation="MVVKTRKQGNSITITIPSEFNIPSGVKYEAKLLPSGEIIFTPEE
                     LGQQVSYVSDDAFDLNLDKIFDEYDDVFKALVEK"
     gene            536..949
                     /locus_tag="VVO18_001995"
     CDS             536..949
                     /locus_tag="VVO18_001995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000158364.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system death-on-curing
                     family toxin"
                     /protein_id="HEU5587071.1"
                     /translation="MTIYLTEKQIEKINALAIQRYSPNEKIQTVSSSALNMIVNLPEQ
                     FVFGKSLYPTIFDKATILFVQLIKKHVFANANKRTAFFVLVKFLQLNGYRFSVTVEEA
                     VKMCVTIAVEALTDEKMTSYSKWVSEHSVREKVKK"
     gene            1067..2032
                     /locus_tag="VVO18_001996"
     CDS             1067..2032
                     /locus_tag="VVO18_001996"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000444451.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU5587072.1"
                     /translation="MESKVTIIMQEMLPLLNNEQLLALRESLEHHLVDGKKQQKYSNN
                     NLLQLFITAKQVEGCSSKTIRYYQRTIENLFNAIKESVTQLTTDDLRSYLANYQSEKD
                     CSKANLDNIRRILSSFFAWLEQEEYIIKNPIRRIKKIKTEQNVKETYTDEHLEIMRDN
                     CENLRDLAIIDLLASTGMRVGELVQLNRSDIDFENRECVVFGKGKKERPVYFDARTKI
                     HLRNYLNDRKDSHPALFVTLVGKVQRLGIAGVEIRLRKLGDKLGIQKVHPHKFRRTLA
                     TKAIDKGMPIEQVQKLLGHSKIDTTLAYAMVNQNNVKHSHQKFIS"
     gene            2066..>2823
                     /locus_tag="VVO18_001997"
     CDS             2066..>2823
                     /locus_tag="VVO18_001997"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000756128.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="restriction endonuclease subunit S"
                     /protein_id="HEU5587073.1"
                     /translation="MKKVKLGQVATFINGYAFKPQDWSSEGKEIIRIQNLTKTSKGIN
                     YYSGTIDKKYIVEAGDILISWSGTLGVFQWCGRSAVLNQHIFKVVFDKIDIDKSYFKY
                     VVEKGLQDAVKHTHGSTMKHLTKKYFDNIMVSYTNLREQQRIASELDLLSKLILRRQE
                     QLEELNLLVKSRFNEMFGDVILNEKEWKVSKWNEILTIRNGKNQKQVEDADGKFPIYG
                     SGGIMGYAKDWIVKKNSVIIGRKGNINKPILVRE"
BASE COUNT         1035 a          397 c          561 g          830 t
ORIGIN      
        1 cagaaattta ttatccatgt tttaaggaat aataattata gtcgagtgat atcaggaagt
       61 gctcagcctc agttaccaat tacaaaatta aaaaaaatac ttctccccct ccccccacta
      121 gccctccaaa atgagttcgc agactttgta gttcagatcg acaaatcaca attggcaatc
      181 caaaaatctc tggaagaact tgaaactttg aagaaatctc tgatgcagga gtattttggc
      241 tgatattctg ccattgtaat tacggtaatg atttgttata atacttcaaa ggaggaaatc
      301 agatggtagt aaaaacaaga aaacaaggaa attcaatcac cattacgatt ccaagtgaat
      361 ttaatattcc aagtggtgtt aaatacgaag cgaaattgtt accaagtggt gagattatct
      421 ttactcctga agaattgggg cagcaggttt cttatgtatc tgatgatgcc tttgacttaa
      481 atttagataa aatatttgac gaatacgacg atgttttcaa agctttggtg gaaaaatgac
      541 aatctatctg acagaaaagc aaattgaaaa aataaatgct ttagcaattc aacggtattc
      601 tccaaatgag aaaattcaaa cagttagttc ttctgcctta aatatgattg tgaacttacc
      661 agaacaattt gtctttggga agtctcttta tccaacaatt tttgataaag caacgatact
      721 atttgtccaa ttgataaaga agcatgtttt tgctaatgct aataaaagaa ctgctttctt
      781 cgttttggtc aaatttttac aattaaacgg ctatcgtttt tctgtaacgg tagaagaagc
      841 agtaaaaatg tgtgtaacca tcgcagtaga agctttaact gatgaaaaaa tgacaagcta
      901 ctccaaatgg gtttctgaac attctgttag agaaaaggtc aaaaagtaac ctagtatgct
      961 ggatttgaat gagcacaaga aaataaatga acagacaata ttagaattct gtaatgcaga
     1021 aactgatatt gtctcttttt attgatgaat aagaaagtga gaaattatgg aatcaaaagt
     1081 tacaattatc atgcaagaaa tgttacctct tttaaataat gaacaattac tagcgttgag
     1141 agagagttta gaacatcatc tagtagacgg aaaaaagcag cagaagtatt cgaataataa
     1201 cctgttgcaa ctatttatta ccgccaagca ggtagagggc tgtagctcaa aaacaattcg
     1261 ttattaccag aggacgattg aaaacttgtt taatgctatt aaagagtctg tgacacaact
     1321 cacaacagat gatttaagga gttatttagc aaattaccag tctgaaaagg attgtagtaa
     1381 ggcaaattta gacaatatta ggcgtatatt gtcttctttt tttgcttggc ttgagcaaga
     1441 ggaatatatc attaaaaatc ccattcgacg gataaagaaa attaagactg agcaaaatgt
     1501 gaaggaaact tatactgatg aacatttgga aattatgcgt gataactgtg aaaatttgag
     1561 agatttggca ataatagacc tactagcatc gacaggtatg cgtgtagggg agcttgtaca
     1621 gttgaatcgt tcagatattg attttgaaaa cagagagtgt gttgtctttg gtaaaggaaa
     1681 gaaggagaga ccagtatatt ttgatgctcg gacgaaaatt catttaagaa attatcttaa
     1741 cgacagaaaa gatagtcacc ctgctctttt tgtaacgcta gttggaaaag tccagagact
     1801 tggaattgct ggtgtagaga ttcgcttaag aaagttagga gacaaactcg gcatacaaaa
     1861 ggttcaccca cataagttca gaagaacttt agcgactaag gcaattgata aaggtatgcc
     1921 tatcgaacaa gtccaaaaac tgctaggtca tagcaagatt gacacaaccc tggcctatgc
     1981 catggtcaat caaaataatg tcaagcattc acaccaaaaa ttcatctctt aaaagcaaat
     2041 cccgatattc cgaggaggtg gttgcatgaa gaaagtgaaa ttagggcaag tggctacttt
     2101 tatcaatggc tatgctttta aacctcaaga ttggtcatct gaagggaaag agattatcag
     2161 aatacagaat ctgactaaaa cttcaaaagg gataaattat tattcgggta cgattgataa
     2221 aaaatacatt gttgaagctg gtgatattct tatttcgtgg tcgggtacat taggggtttt
     2281 tcagtggtgt ggaagatccg cagtgttaaa tcagcacatt tttaaagtgg tttttgataa
     2341 gatagatata gataaatcgt attttaaata tgttgttgaa aaaggtttgc aagatgctgt
     2401 aaaacatact catggttcca caatgaaaca tttaactaaa aaatattttg ataatattat
     2461 ggtttcatat acaaatttga gagagcaaca aagaattgca agtgagctgg atttgttaag
     2521 caagctgatt ttaaggagac aagaacaact tgaagagctt aatctacttg taaaatcccg
     2581 atttaacgag atgtttgggg atgttattct aaatgaaaaa gaatggaaag ttagcaaatg
     2641 gaacgagatt ctaacaataa gaaatggtaa aaatcaaaaa caggttgaag atgctgatgg
     2701 gaaatttcct atttatggaa gtgggggaat tatgggatat gctaaagatt ggatagtgaa
     2761 gaaaaattca gttattattg gacgtaaagg aaatataaat aaacctattt tagttagaga
     2821 aaa
//
LOCUS       DAVHIZ010000106         2762 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.108, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000106 DAVHIZ010000000
VERSION     DAVHIZ010000106.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2762)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.108"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..146
                     /locus_tag="VVO18_001998"
     CDS             <1..146
                     /locus_tag="VVO18_001998"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000945326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="phosphate uptake regulator PhoU"
                     /protein_id="HEU5587074.1"
                     /translation="MNYIFEDDGNVSEVIGALDIIHHLDKIAHTTQSIYKWIMYRKYG
                     NIN"
     gene            159..1634
                     /gene="galT"
                     /locus_tag="VVO18_001999"
     CDS             159..1634
                     /gene="galT"
                     /locus_tag="VVO18_001999"
                     /EC_number="2.7.7.12"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000848801.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose--hexose-1-phosphate
                     uridylyltransferase"
                     /protein_id="HEU5587075.1"
                     /translation="MKTIIDNFVDRVIEYGMYNEIDKIYVKNRVLALIGEEGTDRISD
                     ENDLKQIKDYLVEIALKNGKIKDLIEEKECLGAELMNFIVPLPSRLNDIFWSSYDISP
                     QEAVEEFYKLSKDSDYIKTSAIAKNIEFRASTKYGELEITINLSKPEKDPKTIAAEKL
                     VKATNYPKCLLCMENEGYQGRINYPARSNHRIIRLKLGDEVWGFQYSPYSYFNEHAIF
                     LNSQHVPMAITSKTFEQLLEIVDILPGYFAGSNSDLPISGGSILSHNHYQGGKHIFPM
                     EKAKFESEFRFKDFEDVNAGIVKWPMSVIRLQSENKNRLLDLATKILNKWREYSDLEV
                     DIIAMSEDIPHHTVTPIARKVDGRYELDIVLRDNHTTEQYPDGVFHPHQDVQHIKKEN
                     IGLIEVMGLAILPPRLKTELEEVGKYLLGEDNAIAAYHLEWADQLKEKYSGINKEEVN
                     SVVQHEAGQVFARVLEDAGVYKNTPSGHEAFMRFVKSVGIN"
     gene            1647..2657
                     /gene="galE"
                     /locus_tag="VVO18_002000"
     CDS             1647..2657
                     /gene="galE"
                     /locus_tag="VVO18_002000"
                     /EC_number="5.1.3.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996568.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="HEU5587076.1"
                     /translation="MAILVTGGAGYIGSHTVVELLNLGKEVVIVDNLSNSSILVLDRI
                     EAITGIRPVFYELDVCDKQALRKVFEQESIDAAIHFAGYKAVGESVQKPVMYYKNNIM
                     STLALVEVMSEFNVKKIVFSSSATVYGINNQSPLIETMQTSATNPYGYTKVMLEQILK
                     DVHVADSEWSIALLRYFNPIGAHESGLIGEDPSGIPNNLMPYIAQVAVGKLSELSVFG
                     NDYDTLDGTGVRDYIHVVDLAIGHIKALEKVSEKTDVYIYNLGSGEGTSVLQLVNTFE
                     SVNKIPIPYKIVPRRSGDVATCYANADKAYKELNWRTTKSIEDMCRDTWNWQSKNPNG
                     YN"
BASE COUNT          978 a          370 c          572 g          842 t
ORIGIN      
        1 taatgaatta catatttgaa gatgatggga acgtttctga agtaattggt gctttggata
       61 ttattcatca ccttgataaa attgctcata ctacgcaatc aatttataaa tggataatgt
      121 atagaaaata tgggaacata aattagaaag aaatatatat gaaaacaatt attgataatt
      181 ttgttgatag agtaattgaa tacggaatgt ataatgaaat tgacaaaata tatgtgaaaa
      241 atagagtact agcgttaata ggtgaggagg gaactgatcg catttccgat gaaaatgacc
      301 tgaaacaaat aaaagattac ttagtggaaa tcgccttaaa aaacggtaaa attaaagatt
      361 taatcgagga aaaggaatgt ttaggggcag agttaatgaa tttcatagtt cctttaccta
      421 gtcgattaaa tgatattttt tggagttcat atgatatatc acctcaagaa gcagttgaag
      481 agttttataa gttaagtaaa gatagtgatt atataaaaac ttctgctatt gctaagaata
      541 ttgagtttcg agcatcaact aaatacggag agctagagat tacgataaat ttgtcaaaac
      601 ccgaaaaaga tccaaaaaca attgctgctg aaaaattagt aaaagcaact aattatccca
      661 aatgtttact atgtatggaa aatgaaggat atcaggggcg aataaattat ccagcacgtt
      721 cgaatcatag aattattcgg ttgaaacttg gtgacgaagt atggggattc cagtattctc
      781 cctactcata ctttaatgag catgcgatat ttttgaatag tcaacatgta ccaatggcta
      841 ttacctctaa aacatttgaa caattattgg agattgttga tattttgcca ggatattttg
      901 ctggttcaaa ttctgatctt cctatctcag gaggctccat tcttagtcat aaccactacc
      961 agggagggaa acatattttc ccaatggaaa aagcaaaatt tgagagtgaa tttcgtttta
     1021 aagactttga ggatgttaat gctggtattg taaaatggcc aatgtcagta attaggttac
     1081 aaagtgaaaa taaaaatcgc ttgttagatt tagctactaa aattctaaat aagtggagag
     1141 aatattcaga tttagaagta gacatcattg ctatgtctga agatattcca caccatacgg
     1201 tgactcctat tgctcgtaaa gtagatggga gatatgaatt ggatattgtt ctgagagata
     1261 atcatactac tgaacaatac ccagatggtg ttttccatcc tcatcaagat gtacaacata
     1321 ttaaaaagga aaatattggg ttaatcgaag tgatgggact tgcgatatta ccacctcgtt
     1381 tgaaaacaga gttagaagaa gttggaaaat atcttttagg agaagataat gcaattgcgg
     1441 cttatcattt agaatgggcc gaccaattga aagaaaaata ttctggtatt aacaaagaag
     1501 aggttaatag cgtagttcaa cacgaagcag gacaagtgtt tgcgagagtt cttgaagatg
     1561 caggtgttta taagaatact ccgtctggac atgaagcgtt tatgagattt gttaaatcag
     1621 ttggaattaa ttaggaggaa acccaaatgg caatattggt aacaggcggt gctggttata
     1681 ttggtagcca taccgtagta gaattactaa atttaggaaa ggaagtcgtc attgttgaca
     1741 acctttctaa ctctagcatc ttggtgttag accgtattga agcaattaca ggaatacgtc
     1801 ccgtgtttta cgaattagat gtttgtgata aacaagcatt gagaaaggta tttgaacaag
     1861 aatcgattga tgctgcaatt cattttgcag gttataaagc tgtcggagaa tccgtgcaaa
     1921 agcctgtgat gtactacaaa aataatatta tgagtacatt ggcacttgtt gaagtgatgt
     1981 cagaatttaa tgttaaaaag attgtctttt cttcaagtgc gactgtatat ggaattaaca
     2041 atcagtcacc tctaattgag acgatgcaaa caagtgcgac aaatccttat gggtatacga
     2101 aagtgatgct tgagcaaatt ttaaaagatg ttcatgtggc agattcagaa tggagtattg
     2161 cgttgcttcg ttatttcaat ccaattggtg ctcatgagtc tggtttgatt ggggaagatc
     2221 cctcaggaat tcctaacaac ttgatgccct atattgcgca agtagcggta ggtaagctgt
     2281 cagagctaag tgtgttcgga aatgattatg atacgcttga tggtactggt gtgcgtgatt
     2341 atatccatgt agtagattta gcaataggac atataaaagc tttagaaaaa gtatctgaaa
     2401 aaacagatgt ttatatctat aacctaggct cgggagaagg cactagtgta ttacaacttg
     2461 taaatacatt tgaaagtgtt aataagatcc ctattcctta taaaatagtt ccaagacgtt
     2521 caggagacgt tgcaacttgt tatgcaaatg cagacaaagc atataaggaa ttaaattgga
     2581 ggacaacaaa atcgattgaa gacatgtgta gagatacatg gaattggcaa tcaaaaaatc
     2641 ccaatggcta taattgatga tactgtctat atgagtgttg tattttggga aaattactta
     2701 accttttaat gaaagataat tttttaaaaa aatgtttgaa agcgcttgac aaagtaaacg
     2761 gt
//
LOCUS       DAVHIZ010000107         2567 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.109, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000107 DAVHIZ010000000
VERSION     DAVHIZ010000107.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2567)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.109"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..198)
                     /locus_tag="VVO18_002001"
     CDS             complement(<1..198)
                     /locus_tag="VVO18_002001"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587077.1"
                     /translation="MTTKKANITIEEYIEMSEVDFNEAVNYEFTSDTCQLANSIYQSL
                     FKFFDKKNFSGDLIFTWKSPSL"
     gene            complement(212..925)
                     /locus_tag="VVO18_002002"
     CDS             complement(212..925)
                     /locus_tag="VVO18_002002"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000499426.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjjG family noncanonical pyrimidine
                     nucleotidase"
                     /protein_id="HEU5587078.1"
                     /translation="MFYKFLLFDLDHTLLDFDAAEDVALTQLLKEEGVADIQAYKDYY
                     VPMNKALWKDLELKKISKQELVNTRFSRLFSHFGQEKDGSFLAQRYQFYLAQQGQTLS
                     GAHDLLDSLIERDYDLYAATNGITAIQTGRLAQSGLVPYFNQVFISEQLQTQKPDALF
                     YEKIGQQIAGFSKENTLMIGDSLTADIQGGNNAGIDTIWYNPHHLENHTQAQPTYEVY
                     SYQDLLDCLDKNILEKITF"
     gene            complement(1384..1764)
                     /locus_tag="VVO18_002003"
     CDS             complement(1384..1764)
                     /locus_tag="VVO18_002003"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000443785.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS-dependent dihydroxyacetone kinase
                     phosphotransferase subunit DhaM"
                     /protein_id="HEU5587079.1"
                     /translation="MESIGIGLVIVSHSKHIAEGVVELISKVAKDVPITYVGGTEGGG
                     IGTSFDQVDRVVSENPADTLLVFFDLGSAKMNLKMVTDFSDKSIIINRVPIVEGAYNA
                     AALLQAGAELSVIQTQLAELEINK"
     gene            complement(2186..>2567)
                     /locus_tag="VVO18_002004"
     CDS             complement(2186..>2567)
                     /locus_tag="VVO18_002004"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="histidine motif-containing protein"
                     /protein_id="HEU5587080.1"
                     /translation="RNKNGQADTNQTEKPNEEKPQTEKPEEETPREEKPQSEKPESPK
                     PTEEPEEESPEESEEPQVETEKVEEKLREAEDLLGKIQDPIIKSNAKETLTGLKNNLL
                     FGTQDNNTIMAEAEKLLALLKESK"
BASE COUNT          786 a          505 c          410 g          866 t
ORIGIN      
        1 taatgatgga gatttccaag taaaaattaa atcgccagag aaatttttct tatcaaaaaa
       61 cttaaaaaga gattgataaa tactatttgc taattgacaa gtgtcagatg taaattcata
      121 attaacagct tcattaaaat caacttcaga catttcaatg tactcttcaa tagtaatatt
      181 agcttttttt gtagtcatta gctaatctcc tttaaaatgt gatcttttca agaatatttt
      241 tatctaaaca atccagcaag tcttggtaag aatagacttc gtaagtcggc tgggcttgtg
      301 tgtgattttc gaggtgatga ggattatacc agatagtgtc aatccccgca ttattgccac
      361 cttgaatgtc ggcggttaga gaatctccaa tcatcagcgt attttcttta ctaaatccag
      421 caatttgctg gccaatcttt tcataaaaga gagcatccgg cttttgagtt tgcaactgtt
      481 ctgagataaa gacttgattg aaataaggta ctagaccaga ttgagccaaa cgtcctgtct
      541 gaatggcagt aatgccattt gtcgcagcat acaagtcata atcacgctca atgaggctgt
      601 ccaagagatc atgagcgccc gatagtgttt gtccctgctg agcgagataa aattggtaac
      661 gctgggcaag aaaactaccg tctttttcct gtccaaaatg agaaaataaa cgagaaaagc
      721 gcgtgttaac cagctcttgt ttactgattt tcttcagctc caagtctttc cagagagcct
      781 tgttcatagg aacgtaataa tctttataag cctgaatatc cgcaactcct tcttctttta
      841 gaagttgggt caaagccaca tcctcagcag catcaaaatc aagaagagtg tggtcgaggt
      901 cgaagagtag aaatttgtag aacaatttga ggttttcctt tctgaaaatt cattaagaac
      961 attatatcat aaagcacctc atacaattaa ctaatttaat cacttaaaaa aaattcgaac
     1021 actttctata caactgacag ctcaaatctt tcagaataga acaatactaa ctatcgaaca
     1081 ccccgccttc ataaatacat atgtaattct aggcctagaa ttcctataaa ctaaatgctt
     1141 tcatactctt ccaagtaatt gattgcctta aattttaatt tttgaaggat tctaaagcta
     1201 gaatagcccc atcacaatca gttttgattg attcacaatt tagaaacact atagtttcac
     1261 tcctgttaaa ataaaaagga actgcataaa gcaatccctt tctgattttg aaatcattta
     1321 cttaacattt tatagttgag ataatcaata gcttacctat aaaaagagtt atagtaaaat
     1381 tccttattta ttgatttcaa gctccgctaa ctgtgtttga ataactgaca gttctgcacc
     1441 agcctgaaga agagcagctg cattataggc accttctaca attggaaccc tgttgatgat
     1501 gatactttta tcactgaaat cagtcaccat ttttaagttc attttagcag aacctaggtc
     1561 aaaaaataca agtaaagtat ctgctggatt ttcggaaaca accctatcta cttgatcaaa
     1621 actcgttcca attcctccgc cctcggttcc tcctacataa gtaatcggaa catctttagc
     1681 tactttacta atcagttcaa caacaccttc cgcaatgtgt ttggaatgtg aaacgataac
     1741 aagaccaata ccaatacttt ccatcaaacc accccagttt ctaaaatagc agtaaagagt
     1801 aatcctgatg agaatgatcc aggatcaata tgtccaagaa accacatgct cctaagacaa
     1861 gagctaacag actggccatc aataatagta ttgttctttt tttcatcatt actccttaac
     1921 tagtgtttaa ctgattaatt agccagtaaa tagtttatct ttatttacac tatctgttaa
     1981 gatatagtaa aatgaaataa gaacaggaca gtcaaatcga tttctaacaa tgttttagaa
     2041 gtagaggtat actattctag tttcaatcta ctatattttg cacattttca tgaaaaaaat
     2101 gagaactaga actcacattc tgctctcatt tttcgttttc ccgttctcct atcctgtttt
     2161 taggagttag aaaatgctgc tacctttact tactctcctt taataaagcc aatagttttt
     2221 cagcttctgc cataatagta ttgttgtcct gggtgccaaa tagtaaatta ttttttaatc
     2281 ctgtgagagt ctctttggca ttggacttga taattggatc ctggattttt ccaagtaaat
     2341 cttcagcctc tctcagtttt tcttcaacct tttcagtctc gacctgaggt tcttctgatt
     2401 cctctggtga ttcttcttct ggttcctctg ttggttttgg agactctggt ttctcgcttt
     2461 gcggtttctc ttctcgaggg gtttcttcct caggtttttc tgtctgaggt ttctcctcgt
     2521 ttggtttctc cgtttgattg gtatcagctt gaccattttt gtttctt
//
LOCUS       DAVHIZ010000108         2491 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.110, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000108 DAVHIZ010000000
VERSION     DAVHIZ010000108.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2491)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.110"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            20..2155
                     /locus_tag="VVO18_002005"
     CDS             20..2155
                     /locus_tag="VVO18_002005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841293.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S8 family peptidase"
                     /protein_id="HEU5587081.1"
                     /translation="MKYLHFSLEETKTYWEKNNIIDGILISIYYNRIVAKSNRINGYF
                     NVGGGNPFPNDTIVGAKFNDEKTKHIVTHYISRDALNKTITVLSKIIEVFEEHFDRAI
                     TCEMFSDSSTFASINFSEYGISKSKFQQYLRDSCFIENFGVEHTTVSDIQNSIVTFYD
                     VHTDIFRLLNKLNIDISEANIMNQTTVLLDEKNIELLLSKAPYLVSMIVEDFSKLSVD
                     DFSLDNNDLKINLPSPMNEPVVGVIDTLFDKRVYFNEWVEYHDFVSPDISKDSQDYKH
                     GTAVTSLIVDGANLNPNLDDGCGNFRVRHFGVSLQSGFNSFTIIKQIKEIVSQNADIK
                     VWNLSLGSNDEIRENFISAEGALLDEIQFENDVIFIIAGTNASVINGKRKRIGAPADS
                     LNSIIVNSVDFNNQSVSYSREGIVLSFFVKPDVSYYGGGNGDFINVCEPLGLGRVAGT
                     SFAAPFIARKMAYLIHIMGLSREEAKALLIDAAIPWNDKKTFTDLSLIGNGIVPIKMD
                     DILSTPDDEIKFIVSDISRAYDTYNYDFPVPISSESYPYVAKATMCYFPNCSRKQGVD
                     YTNTEMQLTFGRLKSDGIKSINKDNQHAEDSPGYVRENAARNIFRKWDNVKHIGESFT
                     SRKRAKAILNPSNPQWGMSIKTIERLKSGDGQGVRFGVVVTLKELNGVNRIEDFIQQA
                     ELRGWLVNRLQVEAQVDLFNSLNEEIEFE"
     gene            2206..>2491
                     /locus_tag="VVO18_002006"
     CDS             2206..>2491
                     /locus_tag="VVO18_002006"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001028052.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tryptophan synthase subunit beta"
                     /protein_id="HEU5587082.1"
                     /translation="MNITYIVGNGLDLQYGLKTRYRDFYEFQNKVYISRTENEEKYSN
                     FIYESLFSDKVNDYENWSDFELSIGKLTKDNDLISSSIEIKEKFIDDFSEV"
BASE COUNT          858 a          316 c          485 g          832 t
ORIGIN      
        1 aataattaca ttggaacatt tgaagtatct tcatttttca ttagaagaga cgaaaacata
       61 ttgggagaaa aataacatta tcgatggtat tttgatcagt atttactata atcgaattgt
      121 tgccaaaagt aaccgtatta atggctattt caatgtagga ggagggaatc catttcctaa
      181 tgatactatt gtgggagcaa aattcaatga tgagaagaca aaacatattg ttactcatta
      241 tatttctaga gatgctctta ataaaacaat aaccgtttta agtaagataa ttgaagtttt
      301 tgaggaacat tttgatagag cgataacatg tgagatgttt tctgattcat caacgtttgc
      361 ttctataaat ttttcggagt atggtatttc aaaaagcaaa tttcaacagt atttgagaga
      421 ttcttgcttt attgagaatt ttggagttga gcacactact gtttctgata ttcaaaattc
      481 tatcgtgaca ttttatgatg tccatacaga catttttaga ttactgaata aattaaatat
      541 tgatatttca gaagctaata tcatgaatca gaccacggtc ttgcttgatg aaaaaaatat
      601 tgaattacta ctatcaaaag cgccctatct tgtctccatg attgtggaag atttttctaa
      661 gttatctgta gatgattttt ctttagataa taatgattta aaaataaatc ttccatctcc
      721 aatgaacgaa ccagttgttg gcgttattga taccttattt gacaaaagag tttactttaa
      781 tgagtgggta gaatatcatg attttgtctc acctgatatt agcaaagata gccaagatta
      841 caagcatggg acagctgtga cttctttaat cgttgatgga gccaatttga accctaatct
      901 ggatgatggt tgtggaaatt ttagagtgag gcattttggt gtgtcactac aaagtggatt
      961 taattcattt acaatcataa aacagataaa agagattgtt tctcagaatg ctgatattaa
     1021 ggtttggaat ctttctttag ggtccaatga tgaaataaga gaaaatttta tctctgcaga
     1081 gggagcatta ttagacgaaa ttcaatttga gaatgatgta atttttatca tagctgggac
     1141 aaatgcttca gtaataaatg ggaaacgcaa aagaataggt gctcctgctg attcacttaa
     1201 ttctataata gtaaattctg ttgattttaa taatcaatca gtgtcatatt cacgagaggg
     1261 tattgtttta tcattctttg ttaaaccaga tgtgtcatat tatggaggag gaaatggtga
     1321 ctttataaat gtttgtgaac ctctaggatt aggtcgtgta gctggaacaa gttttgcggc
     1381 accttttatt gcaaggaaaa tggcctatct cattcatatt atgggactta gccgagaaga
     1441 agcgaaggct ttgctaattg atgcagcaat accctggaat gataagaaaa cattcactga
     1501 tttatctttg ataggaaatg gtattgttcc aataaaaatg gatgatattt tatctacacc
     1561 tgatgatgaa attaaattta ttgtgtcaga tatctctagg gcttatgata cctataatta
     1621 tgattttcca gtacctattt ctagtgagag ttatccatat gtagctaaag caacaatgtg
     1681 ttatttccct aactgctcaa gaaaacaagg ggttgattat acaaatactg agatgcagct
     1741 tacttttggt aggttaaagt cagacggtat caaatcgata aataaagaca accagcatgc
     1801 cgaagattcc ccaggatatg tgagagaaaa tgctgctaga aatatattta ggaaatggga
     1861 taatgtcaag catattggag agtcgtttac ttctcgaaag agagctaaag caattttaaa
     1921 tccatctaat cctcagtggg ggatgagtat taaaacaatc gaacgtttga aaagcggtga
     1981 tggacaagga gtacgttttg gtgtagtagt tacattaaaa gaattaaatg gggttaatcg
     2041 tattgaagat tttattcagc aagctgaatt acgcggttgg ctagttaata gattgcaagt
     2101 agaagctcaa gtagacctct ttaatagttt aaatgaagaa attgaatttg aatagtggat
     2161 attttatcct tattttagat cttaggaaca caagagggca aagatatgaa tattacttat
     2221 atagttggaa atggtttgga tttgcaatat ggtttgaaaa caagatatag ggatttctac
     2281 gaattccaaa ataaggttta tataagtagg acagagaacg aggaaaaata ttcaaatttc
     2341 atttatgagt ctctattttc tgataaagta aatgattatg aaaattggtc agattttgaa
     2401 ttgtcaattg gtaaattaac aaaagataac gacctcatct cctcaagtat agaaataaag
     2461 gagaaattta tagatgattt tagtgaagta g
//
LOCUS       DAVHIZ010000109         2448 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.111, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000109 DAVHIZ010000000
VERSION     DAVHIZ010000109.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2448)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.111"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..1746
                     /locus_tag="VVO18_002007"
     CDS             <1..1746
                     /locus_tag="VVO18_002007"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398247.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587083.1"
                     /translation="YKKLFAYVQDKKYLGVLAIIFSAISALLTVYGYYLIYKFLDKLI
                     INSNLSGAESIALKSVITLTSGAIFYFVSGMFSHILGFRLETNLRKRGIDGLEKASFR
                     FFDLNPSGQIRKIIDDNAAQTHQVVAHMIPDSSQAIVTPILVLVLGFIVSIRVGITLL
                     ALTIIGGLILGAMMGEQEFMKIYQEALSKLSAETVEYVRGMQVVKIFKANVESFKIFY
                     KAIKDYSKYAYDYSLSCKRPYVLYQWLFFGLIAILIIPIVYFMTSLASAKVILLELIM
                     ILFLSGVLFVSFMRMMWYSMYISQGNYAVDTLEALYEDMQKDKLVHSNVNNFKNYNIE
                     FENVSFAYNDKAVIENLSFNLEEGKSYALVGSSGSGKSTVAKLISGFYNVNKGSIKIG
                     GIAISEYSDEALIKAISFVFQDSKLFKKSIYDNVALANKDATKDDVMRALKLAGCDLI
                     LDKFPERENTIIGSKGVYLSGGEKQRIAIARAILKDSKIIIMDEASASIDPDNEFELQ
                     KAFKNLMKDKTVIMIAHRLSTIKDLDEIIVMDSGKIIERGSDKELMSKDTRYKSLQEM
                     FNSANEWRVSNERVL"
     gene            1730..>2448
                     /locus_tag="VVO18_002008"
     CDS             1730..>2448
                     /locus_tag="VVO18_002008"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019214631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587084.1"
                     /translation="MKEFYKKRFALTDGGARNLSKATLASFFVYCINMLPAILLMIFA
                     QEVLENMGKSNGFYIVFSVLTLIAMYILLSIEYDKLYNTTYQESADLRIRTAENLSKL
                     PLSYFSKHDISDISQTIMADIEGIEHAMSHSIPKVGGMVLFFPLISVMMPAGNVKMGL
                     AVIIPSILNFIFIPLSKKYQVNGQNRYYDVLRKNSESFQENIEMQMEIKAYNLSKDIK
                     DDLYKKMEDSERVHLKAEVTT"
BASE COUNT          873 a          332 c          453 g          790 t
ORIGIN      
        1 tacaaaaaac tatttgctta tgtccaagat aagaaatatc ttggggtttt ggccataatt
       61 ttttctgcta tatctgctct acttacagta tatggatatt atttaatcta caaatttcta
      121 gataagttaa taattaattc aaatttatcc ggtgcagaga gcatagcatt aaaatctgtt
      181 attacactaa caagtggagc gatattttat tttgtctcag gaatgttttc acatatcttg
      241 ggattcaggc ttgaaacaaa tttaagaaaa aggggaatcg atggtctgga aaaagcaagt
      301 tttaggttct ttgacttaaa tccatctggt caaataagaa agatcataga tgataatgca
      361 gcacaaactc atcaggtggt agctcacatg attcccgata gctctcaggc aatagtcaca
      421 cctatacttg tccttgtact aggctttata gtaagtataa gggttggtat aactttgctt
      481 gctcttacta taattggtgg cttaatttta ggggcgatga tgggcgagca agaatttatg
      541 aagatatacc aagaagctct atctaaacta agtgctgaaa ctgttgagta cgtgagagga
      601 atgcaagttg taaaaatatt taaagcaaat gtagagtctt ttaaaatctt ttataaggcg
      661 ataaaagatt actcaaagta tgcttatgat tattccctat cttgtaaaag gccttatgtt
      721 ttgtatcaat ggttattttt tggactgatt gcaattttaa ttattcctat agtttatttt
      781 atgactagct tagctagcgc aaaggtgatt ttacttgagc ttatcatgat tttattttta
      841 tcaggagttc tctttgtttc attcatgaga atgatgtggt actccatgta tatttctcaa
      901 ggaaattatg cagtagatac tttagaggcg ctttacgaag atatgcaaaa agacaaatta
      961 gtgcatagta atgtcaataa ttttaaaaac tataatatag aatttgagaa tgttagcttt
     1021 gcttataatg ataaagctgt cattgaaaat ttatccttta atttagaaga aggaaagtcc
     1081 tacgcacttg tcggttcatc tggatcaggc aaatcaacag tagcaaaact tatatcaggt
     1141 ttttacaatg ttaataaagg aagcataaag ataggcggga tagcaataag tgaatattct
     1201 gacgaagcct taattaaagc catttccttt gtttttcaag attcaaaatt attcaagaag
     1261 agcatttatg ataatgtagc tttagctaat aaagatgcga cgaaagatga cgttatgaga
     1321 gccttaaaat tagcaggatg cgatttaata ttagacaaat tcccagaaag agaaaataca
     1381 atcataggct caaaaggtgt ttatttatcc ggtggagaaa aacaaagaat tgcaattgct
     1441 agagcaattt taaaggattc caaaattatt attatggatg aagcatcagc atctattgac
     1501 ccagataacg agtttgaatt gcaaaaagct tttaaaaatc ttatgaagga taaaacagtt
     1561 atcatgattg cacacaggct atctacaatt aaagaccttg atgaaattat tgtcatggat
     1621 agtggaaaaa ttatagaaag agggtctgac aaagaattaa tgtcaaaaga tacaaggtat
     1681 aagagcctgc aagagatgtt taacagtgcg aatgaatgga gggtttcaaa tgaaagagtt
     1741 ttataaaaaa agatttgctc ttacagatgg aggagcaaga aatttaagta aagcaacact
     1801 ggcttcattt ttcgtttatt gtataaacat gcttcctgcc atattactta tgatttttgc
     1861 tcaggaagtt ttggaaaata tgggcaaaag caatggcttt tatatagtat tctcagtttt
     1921 gactttgata gcaatgtata ttttgctttc tatcgaatac gataaattat ataacacaac
     1981 ctatcaagaa agtgcagatt taagaataag gacagcggag aatttatcaa aattacctct
     2041 atcttacttt tctaaacatg acatttccga catttcacaa acaatcatgg ctgatattga
     2101 aggcatagag catgcaatga gccactcaat accaaaggtg ggcggcatgg tactgttttt
     2161 cccattaata tctgtaatga tgccagcggg caatgtcaag atgggtttag ctgtaattat
     2221 tccatctatt ttaaacttta tatttatacc tttatctaaa aaatatcagg ttaatggaca
     2281 gaatagatat tatgatgtct taagaaaaaa ctcagaaagc tttcaagaaa atatcgaaat
     2341 gcaaatggag attaaagcat ataatttatc gaaggatatt aaagatgact tatataaaaa
     2401 aatggaagat agtgagagag tacacttaaa ggcggaagta actacaat
//
LOCUS       DAVHIZ010000110         2274 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.112, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000110 DAVHIZ010000000
VERSION     DAVHIZ010000110.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2274)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2274)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2274
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.112"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..1242)
                     /locus_tag="VVO18_002009"
     CDS             complement(<1..1242)
                     /locus_tag="VVO18_002009"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001085099.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587085.1"
                     /translation="MNTKIKNIITSFSYVISSNLLIVLTSSLVVLIFPKIMGVTEYSY
                     WQLYIFYLTYIGFFHLGWIDGIYLKYGGLEYTNLDRKQFYSQMILFSSFLMLISLVLF
                     TLNLITVRDENARYIYNMAIISMIVTNLRTLYVYILQMTNRLKDSSVILISDRVLYVL
                     LLFMFIVFGWHEYKVMIWADILGRTFSLMLSFWICKDIVFQSLSKFILDFKESLDNIR
                     VGINLMLSNIASSMIIGIVRMGIQWNWNIETFGKVSLTLSISNLLMTFINAIGLVIFP
                     LIKRTKTENLPKIYSNLRNALMLVMFAILLFYYPLKFILDIWLPAYKDALVFMALIFP
                     MSVYEGKMALVINTYLKAMRMEKDILKINALVMLTSMVVTLVTTLLLNNLGLTVVSIV
                     ILLALRSIIAELILSKKLKISV"
     gene            complement(1265..>2274)
                     /locus_tag="VVO18_002010"
     CDS             complement(1265..>2274)
                     /locus_tag="VVO18_002010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000120851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="oligosaccharide repeat unit polymerase"
                     /protein_id="HEU5587086.1"
                     /translation="LYLYRKEIYNLVLSNGYTGSNIQWFFRNATSYEGELTVRTFIRV
                     LIRVIDVSAYIFGYTFINNFLIYRHKRPKDILLLVPLLIFISKTLISGGRQDIIKILI
                     AYVIMMYIQQKRKVGWNRVISHKYIHLGFVGLIAGIPAFYYSLFLAGRSTTRTLFESV
                     STYLGGSIQHFNQYIENPLDPGEVFGSETLVPILNILGEMGLVNYRSTIHLEFRTLGV
                     TVGNVYTFFRRPLHDFGLVGMYVFVFAVGAFFAIYYLVLRKKQVGFNLDIHTIIYSYV
                     FYWIFLSSIEQYSFTMISLYTLVFIVLVYFMAIFYWCTDFKRGKLIFKISDSSIKLKE
                     E"
BASE COUNT          891 a          397 c          304 g          682 t
ORIGIN      
        1 gactgatatc ttcagttttt tggataaaat taattcagct attatacttc ttaaagcaag
       61 taaaataact atagatacaa ctgtcagccc caaattattt agtagtagag tagtcactaa
      121 tgtcactacc atactagtta acataaccaa agcattaatt ttgagaatgt ctttttccat
      181 tctcattgct tttaaatatg tatttatcac caaagccatt ttcccttcat aaactgacat
      241 aggaaaaatt agggccatga aaactaaggc atccttataa gcaggaagcc aaatatcaag
      301 aataaatttt aaaggatagt agaagagcaa gattgcgaac ataaccaaca tcaaagcatt
      361 tcttaaatta gaataaattt taggtaaatt ctcagtcttt gttcgcttta tcaaaggaaa
      421 gataactaat ccaatggcat taataaaagt cattaataaa ttagatatac tcaaagttaa
      481 tgacactttc ccgaatgttt caatattcca attccattga attcccatac gaacaatgcc
      541 tataatcatg ctactcgcaa tgttagatag cattaaattg attccaacac ggatattatc
      601 aagggactcc ttgaaatcta agataaattt tgacaaagac tgaaacacaa tatctttaca
      661 aatccagaag gaaagcatga gagaaaatgt tcgacctaga atatcagccc aaatcatgac
      721 cttgtactca tgccatccaa atacaataaa catgaataaa aggagtacat ataaaacgcg
      781 atcactaatt agaatgactg aactatcctt caagcgattt gtcatctgca agatataaac
      841 atagagtgtt cttaagtttg tgactatcat gctaatgata gccatattat aaatatatct
      901 tgcgttttca tcccttacag ttattaggtt caaagtaaat aataccagcg agattagcat
      961 taagaaacta gaaaatagaa tcatctgaga ataaaactgt tttctatcta aatttgtata
     1021 ttctaagcca ccatatttga gataaatccc atcaatccaa cccaagtgga aaaaaccgat
     1081 ataggtcaga taaaaaatat aaagttgcca gtaactgtac tcagttaccc ccattatttt
     1141 aggaaaaatc aaaacaacta gtgatgaggt taaaactatg agcagatttg aagaaataac
     1201 ataagaaaaa ctagttatta tatttttaat tttagtattc atctaccctc tcctatacat
     1261 tctgttattc ttcttttaat ttgatacttg agtcagaaat tttaaaaatc agttttcctc
     1321 ttttaaaatc tgtacaccag taaaagatag ccataaagta aaccaacaca ataaatacaa
     1381 gtgtatatag actaatcatt gtgaacgagt attgctcgat tgatgataaa aaaatccaat
     1441 aaaagacata agaataaata atggtatgaa tatccaaatt aaaaccaacc tgtttctttc
     1501 tcagaactaa ataataaata gcaaaaaaag cacctacagc aaagacaaat acatacatac
     1561 caactagacc aaaatcatgc aagggtcttc taaaaaaagt ataaacattt cctacagtaa
     1621 ctcctagtgt ccgaaattct aaatgaattg tactacgata attaactagg cccatttccc
     1681 ctaatatatt taatataggc accaatgttt cactgccaaa aacttcacca ggatctaatg
     1741 gattttcaat atactgatta aaatgctgaa ttgagcctcc tagataggtc gaaacactct
     1801 caaatagcgt cctagtcgtt gaacgaccgg ctaaaaacaa agagtagtaa aatgctggaa
     1861 tacctgctat taaaccaaca aatccaaggt gaatatattt atgagatatg actctattcc
     1921 atccaacttt ccgtttttgt tggatataca tcatgattac ataggcaatc agaattttaa
     1981 taatatcttg ccggcctcct gatattaaag tttttgaaat aaatattaat aaaggtacta
     2041 aaagtaatat gtctttaggg cgtttatggc gatagataag aaaattatta ataaaagtat
     2101 atccaaaaat ataagcagat acgtcaataa cacgaatgag aactcgaata aaagttcgca
     2161 ctgtcaattc accttcataa ctcgttgcat ttctaaaaaa ccactgaata tttgaccccg
     2221 tatatccatt actaagaaca aggttgtata tttccttcct gtaaagatac aaaa
//
LOCUS       DAVHIZ010000111         2231 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.113, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000111 DAVHIZ010000000
VERSION     DAVHIZ010000111.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2231)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.113"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..672
                     /locus_tag="VVO18_002011"
     CDS             <1..672
                     /locus_tag="VVO18_002011"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611512.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="HEU5587087.1"
                     /translation="RIYLELRNRAYLVNHKRVQGLMKVLNLQAKMRQKRKYSSHKGDV
                     GKKAENLIQGQFEGSKTMEKCYTDVTEFAIPASTQKLYLSPVLDGFNSEIIAFNLSCS
                     PNLEQVQTMLEQAFTEKHYENTILHSDQGWQYQHDSYHQFLEGKGIQASMSRKGNSQD
                     NGMMESFFGILKSEMFYGYEKTFKSLNQLEQAIVDYIDYYNNKRIKVKLKGLSLVQYR
                     TKSFG"
     gene            complement(788..1591)
                     /locus_tag="VVO18_002012"
     CDS             complement(788..1591)
                     /locus_tag="VVO18_002012"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001866401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Fic/DOC family protein"
                     /protein_id="HEU5587088.1"
                     /translation="MQSTYNIDNPNLSYEAKRDLWRIGFGLQKVDNLVPSAYMESLAE
                     KQSRGELTYEQVYEDATAYHHTIDASTEEADLVSLRIVELLSRRGFSFSPATLLAIHK
                     ELFQDIFEPSIPVGQFRQTNITKNEPVLNGESVVYSDYSMIQMTLDYDFNQEKQVAYA
                     TLTQADVVKQIQHFISGIWQIHPFREGNTRTVTVFLIQYLREFGFDIDNTPFQQHSKY
                     FRDALVLDNAKILQRRSEFLTAFFENLLLGGQNDLFSEKMYLDLDLDFS"
BASE COUNT          751 a          402 c          384 g          694 t
ORIGIN      
        1 cggatttatt tagaactaag aaatcgtgct tatctggtaa atcataaaag agttcaaggc
       61 ttgatgaaag tactcaattt acaagctaaa atgcgacaga aacgaaaata ttcttctcat
      121 aaaggagacg ttggcaagaa ggcagagaat ctcattcaag gccaatttga aggctctaaa
      181 acaatggaaa agtgctatac agatgtgaca gaatttgcca ttccagcaag tactcaaaag
      241 ctttacttat caccagtttt agatggcttt aacagcgaaa ttattgcttt taatctttct
      301 tgttcgccta atttagaaca agtacaaaca atgttggaac aggcattcac agagaagcac
      361 tacgaaaata cgattctcca tagtgaccaa ggctggcaat accaacacga ttcttatcat
      421 cagtttcttg agggtaaggg aattcaagca tccatgtcac gtaagggaaa cagccaagac
      481 aacggtatga tggagtcctt ctttgggatt ctgaaatcgg aaatgtttta tggctatgag
      541 aaaacattta aatcacttaa tcaattggaa caagctattg tagactatat tgattactac
      601 aacaataaac gaattaaggt aaaactaaaa ggacttagcc ttgtgcaata cagaactaaa
      661 tccttcggat aaattatttg tctaactttt tggggtcagt acacctaaaa ctttgatgat
      721 atacgttttc ttgtgagaat atttacttca tttttgccta aaattcaatg tttactcagt
      781 atttggatta tgaaaaatcg aggtctaaat ctagatacat tttttctgaa aacaaatcat
      841 tttgaccacc gagcaagaga ttttcaaaaa aagctgttaa aaactcagaa cgtcgctgta
      901 aaatctttgc attatctaat accaaggcat cacgaaaata tttggaatgt tgctgaaatg
      961 gtgtattatc aatatcaaaa ccaaactcac gaagatactg aatcaaaaag accgttactg
     1021 tccgagtgtt tccttcgcga aatggatgaa tctgccagat tcctgaaata aaatgctgga
     1081 tttgtttaac cacatccgcc tgagttagtg tcgcatatgc aacttgtttt tcctgattaa
     1141 aatcataatc taaggtcatt tgaatcatgg agtaatcaga gtacacaaca ctttcaccat
     1201 tcaaaacagg ttcattcttt gtgatattgg tctgacgaaa ttgccccacc ggaatagagg
     1261 gttcaaatat atcttgaaac aactccttat gaatagcaag taaggtcgca ggactaaagc
     1321 taaagcctct tcgagacaat agttctacaa tacgtagaga aaccaagtct gcctcttccg
     1381 tacttgcatc aatagtatgg tgataagccg ttgcatcctc ataaacctgc tcataagtca
     1441 gttctccccg ggactgtttc tcagccaaag attccatata cgctgatggc actagattgt
     1501 caactttctg cagaccaaaa cctatccgcc ataaatcacg cttcgcttca taagacaagt
     1561 ttggattgtc aatgttgtaa gttgattgca tagaaatatc ctttcaattg tttttctgtg
     1621 tcatcggtaa attgtgaaat aggtatggaa ttggcgaaaa ttataaaaat ccttcacaat
     1681 aggttctatg aaatatatat acttcatctt aatagtgagc aagctaaact tagcatttca
     1741 tgccctcata tgggatgttc tttaactaaa taatatgatt atcgagatat atctggataa
     1801 atgaactaat aagtctgacg cgtagactta tcaaagtcat tggcatacac cactatgaac
     1861 tcgttgatct gttcaaatcc caacacatta cctgagaaga aagttgcaat gttgtttttg
     1921 gtgcgggttt gaatttaaaa atttgttatg tagtacctaa tctaaggaat tagaacaatg
     1981 cctctaattt ttctttaata cactgaaaca ttgatgattc tggctgtatt tttgaaacag
     2041 ctcttctttg ctcctggaaa atatcttcag aagttatatt ctctattcct aacgctactt
     2101 gaattttttt ctaaaatatt cttttccgtt gccatcttta gaaaaatcat aaccttccct
     2161 atctacgctg ttacataaat tagctaaaaa aaactatggg gttgggaaag gaagataaga
     2221 aacgtattta g
//
LOCUS       DAVHIZ010000112         1789 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.114, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000112 DAVHIZ010000000
VERSION     DAVHIZ010000112.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1789)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1789)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.114"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..432)
                     /locus_tag="VVO18_002013"
     CDS             complement(<1..432)
                     /locus_tag="VVO18_002013"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358304.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587089.1"
                     /translation="MDKKERQKIEQQRREMALTNTFFNRYLLLRYSIALFFFGNIYWL
                     LNQFISPSPIIIFPIMLIVFSILATVEQFKLYGNRKEKLGITLMFVRIQMLISIGLLV
                     LTWTSWFKNLFPIFENNQVARLFVFVVLLLGLVLSLLDIRRI"
     gene            complement(463..777)
                     /locus_tag="VVO18_002014"
     CDS             complement(463..777)
                     /locus_tag="VVO18_002014"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001070943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS cellobiose transporter subunit IIA"
                     /protein_id="HEU5587090.1"
                     /translation="MNQEELQVAAFEIILHSGNARSEIHEAFAKMREGSFDDAESKLN
                     QSNEIILEAHHAQTKLLQEYASGVEIKIEIIMVHAQDHLMTTMTLLEVAKEMLALYKK
                     VN"
     gene            complement(787..>1789)
                     /locus_tag="VVO18_002015"
     CDS             complement(787..>1789)
                     /locus_tag="VVO18_002015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001861534.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="BglG family transcription antiterminator"
                     /protein_id="HEU5587091.1"
                     /translation="QLIEGLITHLMTLQVRLESRITLNNPLVDEIKQNYSDIFFMTRE
                     ILANMDKFLEWTISDDEVAYVSLHFLAAMERSKESTKFNILAICATGFGAAQMLRNRL
                     ETEFGKRVEVVDVIGYYELNQEKLKGIDFIVSAVDLSNLYFQIPVFKVSVFLKSDEME
                     MIRKAMDQMQVSSYVQSSKINKFENNSFRQYFSKENFLICTESDKVNLLEKMVEGLSV
                     GESNEFEQSLLYGIKQREELSSVVFSEKIAVPHPIQPFGTEGKVSVAICKDSLLWDNQ
                     SSHVQLVFLLSPSIYGNEGLATVTKKIVSLTENDELQNQLISCNNFEDFINIFEKIK"
BASE COUNT          594 a          339 c          231 g          625 t
ORIGIN      
        1 aattcttcta atgtctaaca aactcagaac taaacctaat agaagaacta caaaaacaaa
       61 taaacgtgct acttggttat tttcaaaaat cggaaaaaga ttcttaaacc aacttgtcca
      121 agttaaaaca agtaatccta ttgaaataag catttgtatt ctaacaaaca ttagtgttat
      181 tcccaacttt tctttcctat ttccatagag tttaaattgt tcaacagttg ctaaaataga
      241 aaatactatg agcataatgg ggaaaataat aataggcgag ggactaataa actgattcaa
      301 aagccaataa atattcccaa aaaagaagag tgctattgaa taacgtagaa gaagatatcg
      361 attgaaaaaa gtattagtta gagccatctc tcgacgttgt tgttcaatct tttgtcgttc
      421 ttttttatcc atatcatttc ctccttatat aacaacacat atttagttaa ctttcttata
      481 aagagctaac atttcctttg ctacttctaa taatgtcata gtggtcatta aatgatcttg
      541 agcatgtacc atgataattt caattttaat ttccactcca cttgcgtatt cttgcaagag
      601 tttggtttgt gcatgatgcg cttcaagaat tatctcattt gattgattta atttactttc
      661 tgcatcatca aaactacctt ctctcatttt tgcaaatgct tcatgtattt ctgaccttgc
      721 atttcccgaa tgcaggataa tttcaaatgc tgcaacctgc agttcctctt gattcatatg
      781 aacctcctat tttatcttct caaatatgtt aataaaatct tcaaagttat tgcaagatat
      841 tagctgattt tgcaattcat cattctctgt cagagagact atctttttag tcacagttgc
      901 caaaccttcg ttcccatata ttgatggaga tagaagaaat actagctgga catgtgaact
      961 ttgattatcc cagagtaacg aatctttaca aattgcaacc gaaacctttc cctctgtacc
     1021 aaagggctga ataggatgcg gaactgcaat tttttcagaa aaaacaactg aacttaattc
     1081 ttcgcgctgt ttaattccat aaagtaaaga ttgttcaaac tcatttgatt caccaacaga
     1141 taaaccctca accatctttt caagtaaatt taccttgtct gattcagtac atattaaaaa
     1201 attttcttta ctaaaatact gtctaaagct gttgttttca aatttgttaa tctttgatga
     1261 ttgtacataa ctagaaactt gcatctgatc catagctttt ctaatcattt ccatctcatc
     1321 acttttaaga aacacactaa ctttaaaaac tgggatttga aaatatagat ttgataaatc
     1381 aacagctgac actataaaat ctattccttt aagtttttct tgattcaatt cataatagcc
     1441 tattacatca acaacttcta ctcgcttccc aaactccgtt tccaaacgat ttcttaacat
     1501 ttgggctgca ccaaatcctg ttgcacaaat agcaagaata ttaaacttag tactctcttt
     1561 gctacgttcc atagcagcta aaaagtgaag acttacatat gctacttcat catctgatat
     1621 tgtccactcc aagaacttgt ccatatttgc aagaatttct ctagtcataa agaatatatc
     1681 actataattc tgtttaattt catctaccaa agggttattt aaggtaatcc ggctttctaa
     1741 acgtacttgt agtgtcatta gatgagttat caatccttca attagttgg
//
LOCUS       DAVHIZ010000113         1728 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.115, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000113 DAVHIZ010000000
VERSION     DAVHIZ010000113.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1728)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.115"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..628
                     /locus_tag="VVO18_002016"
     CDS             <1..628
                     /locus_tag="VVO18_002016"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750039.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="LPXTG cell wall anchor domain-containing
                     protein"
                     /protein_id="HEU5587092.1"
                     /translation="KIVVKDFARNTTVKEFILNKDTGEVSELKPHRVTVTIQNGKEMS
                     STIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKKDAGYVINLSKDTFIKPVFKKIE
                     EKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDLQREDHSQKSDSTKDVTATVLDK
                     NNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVGIFLGLKKKNQD"
     gene            1260..>1728
                     /locus_tag="VVO18_002017"
     CDS             1260..>1728
                     /locus_tag="VVO18_002017"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000242196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIA"
                     /protein_id="HEU5587093.1"
                     /translation="MVLDYFFDKNLVFCLEADNQEHLFDQVASLLEEREIVTPTYREA
                     LITREKSFPTGLDMEFLGKDLPNVAIPHTDIVHNLAEKVVVVRLEKPVTFHNMIAPDK
                     EVEVSLLFFIINNSSSSQTNILAQLMDFFTGNGHLEDLSKISEPEKLYAYIAEA"
BASE COUNT          649 a          238 c          322 g          519 t
ORIGIN      
        1 taagattgtt gtaaaagatt ttgcaagaaa tacaaccgta aaagaattca ttttaaataa
       61 agatacggga gaggtaagtg aattaaaacc tcatagggta actgtgacca ttcaaaatgg
      121 aaaagaaatg agttcaacga tagtgtcgga agaagatttt attttacctg tttataaggg
      181 tgaattagaa aaaggatacc aatttgatgg ttgggaaatt tctggtttcg aaggtaaaaa
      241 agacgctggc tatgttatta atctatcaaa agataccttt ataaaacctg tattcaagaa
      301 aatagaggag aaaaaggagg aagaaaataa acctactttt gatgtatcga aaaagaaaga
      361 taacccacaa gtaaaccata gtcaattaaa tgaaagtcac agaaaagagg atttacaaag
      421 agaagatcat tcacaaaaat ctgattcaac taaggatgtt acagctacag ttcttgataa
      481 aaacaatatc agtagtaaat caactactaa caatcctaat aagttgccaa aaactggaac
      541 agcaagcgga gcccagacac tattagctgc cggaataatg tttatagtag gaatttttct
      601 tggattgaag aaaaaaaatc aagattaaga caaaagctat agaaaaaaat ggtttatgta
      661 ctgagattag atagtgaggt gatgacatag ttttgtgaaa acggccattt ataactcaat
      721 tatttagttt acttcacttc actattgata ctatttggag ttattaatgg acttagttta
      781 gataactaat gaattgattg aaagggttag tattgacaat attggtcata ttgattagaa
      841 aatagagtct atcaaaattt aaaggctaat agaggtgatg agacaatttc aaggaattaa
      901 gtagcgtttg gttgcttaat tcctttttat ttggaaggaa gtttttcgta accgcccaat
      961 aacgaagtct attggacggt tacgatatga tcactgactt cgtcagtctt atctacaacc
     1021 tcaaaactgt gttttgagca acctgcggct agcttcctag tttactcttt gattttcatt
     1081 gaatattaga acagcaaaaa tgcttggagt atttgtttgt gtgtttattt ttatataaca
     1141 aactataaac aaaacaaaaa tataaaaaaa gagacaaaaa agaacaaaaa gtaattgaca
     1201 acggtttcat atagtgttat acttatggca taaagttaat ggaaagaagg gaaaaactta
     1261 tggtattaga ttatttcttt gacaaaaacc ttgtgttttg cttagaagcg gataatcaag
     1321 aacatctctt tgatcaggta gcaagcttgt tggaagaacg agaaattgtc actccaactt
     1381 atcgtgaagc cttgatcacg cgtgaaaagt catttccaac tggtttagat atggaatttc
     1441 taggaaagga cttgccaaat gtagcgattc ctcacacaga tattgttcat aatctagctg
     1501 agaaagtggt ggttgttcga ttagaaaaac cagtaacttt tcacaatatg atagctcctg
     1561 ataaggaagt agaagtatct ctactcttct ttatcattaa caattcaagt tcaagtcaaa
     1621 cgaacattct ggctcagttg atggactttt tcacaggaaa tggtcatctt gaagacctat
     1681 caaaaatttc tgaaccagaa aaactttatg cttacattgc tgaagcaa
//
LOCUS       DAVHIZ010000114         1652 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.116, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000114 DAVHIZ010000000
VERSION     DAVHIZ010000114.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1652)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.116"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            147..1493
                     /gene="gdhA"
                     /locus_tag="VVO18_002018"
     CDS             147..1493
                     /gene="gdhA"
                     /locus_tag="VVO18_002018"
                     /EC_number="1.4.1.4"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001858584.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="NADP-specific glutamate dehydrogenase"
                     /protein_id="HEU5587094.1"
                     /translation="MTSAKEYIQSVFETVKARNGHEAEFLQAVEEFFNTLEPVFEKHP
                     EYIEENILARITEPERVVSFRVPWVDRDGKIQVNRGYRVQFNSAVGPYKGGLRFHPTV
                     NQGILKFLGFEQIFKNVLTGLPIGGGKGGSDFNPKGKTDAEVMRFCQSFMTELQKHIG
                     PSLDVPAGDIGVGGREIGYLYGQYKRLNQFDAGVLTGKPLGFGGSLIRPEATGYGLVY
                     YTEEMLKANGNSFAGKKVVISGSGNVAQYALQKATELGATVISVSDSNGYVIDENGID
                     FDLLVDVKEKRRARLTEYAAEKATATYHEGTVWTYAGNYDIALPCATQNEINGEAAKR
                     LVAQGVICVSEGANMPSDLDAIKVYKENGIFYGPAKAANAGGVAVSALEMSQNSLRLS
                     WTREEVDGRLKDIMTNIFNTAKTTSETYGLDKDYLAGANIAAFENVANAMIAQGVV"
BASE COUNT          510 a          316 c          334 g          492 t
ORIGIN      
        1 aaacgttcgt ttttttatct attttcaaaa aaaccaaaaa ctgaattgaa agaattttta
       61 gaaaatttct gttttttctt tacagtgaaa aaaaattctg ctataatgtc ttatgtaata
      121 aaatatgaca ataaaaggag aacgatatga catctgctaa agaatatatc caaagcgtgt
      181 ttgaaactgt gaaagctcgt aacgggcacg aggctgaatt cctccaagct gttgaagaat
      241 ttttcaacac tttagaacct gtatttgaaa aacaccctga gtatatcgaa gaaaatatct
      301 tggcacgtat tactgagcct gagcgcgtgg tttctttccg tgttccttgg gttgaccgtg
      361 atggaaaaat tcaagtaaac cgtggttacc gtgttcaatt caactcagct gttggaccat
      421 acaaaggtgg acttcgtttc cacccaactg taaaccaagg gatcttgaaa ttcctcggat
      481 ttgaacaaat ctttaaaaat gtcttgactg gacttcctat cggtggaggt aaaggtggat
      541 cagacttcaa tcctaaaggt aaaacagatg ctgaagtgat gcgcttctgc caaagcttca
      601 tgactgaatt gcaaaaacac atcggaccat cacttgacgt acctgctggt gatatcggtg
      661 ttggtggacg tgagattggt tacctttacg gtcaatacaa acgtcttaac caatttgatg
      721 ctggtgtctt gactggtaaa cctcttggat ttggtggtag cttgattcgt ccagaagcaa
      781 ctggttacgg tttggtttac tatactgaag aaatgctcaa agctaacggt aacagctttg
      841 ctggtaagaa agtcgttatt tcaggttctg gtaacgttgc tcaatatgct cttcaaaaag
      901 caactgaact cggtgcaact gttatttctg tttctgactc aaatggttat gtcatcgatg
      961 aaaatggtat cgacttcgat cttttggttg atgttaaaga aaaacgtcgt gctcgtttga
     1021 ctgagtatgc agctgaaaaa gcaactgcaa cctaccacga aggtactgta tggacttacg
     1081 ctggaaacta tgacattgct cttccatgtg ccactcaaaa cgaaatcaac ggtgaagcag
     1141 ctaaacgttt ggttgctcaa ggcgttatct gtgtatctga aggtgccaac atgccaagcg
     1201 accttgatgc catcaaagtt tacaaagaaa atggtatctt ctacggacct gcaaaagctg
     1261 ccaacgctgg tggtgtagcc gtttcagccc ttgaaatgag ccaaaacagc cttcgcctct
     1321 catggactcg tgaagaagtt gatggacgtc tcaaagacat catgaccaac atctttaaca
     1381 cagctaaaac aacttcagaa acatatggtc ttgataaaga ctaccttgca ggagctaaca
     1441 ttgctgcctt tgaaaatgta gcaaacgcta tgattgccca aggcgtggta taaaaaaaaa
     1501 ttacggaaac tgactaccca gacgggtagc cagttttttc aattcctaaa atttaagatt
     1561 ctaataccct ttatgcaaaa atatagaatt ctaccttttt ctttatatag gctaatgttt
     1621 ttaatatatt tattgtctat ttttgaaaag ac
//
LOCUS       DAVHIZ010000115         1630 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.117, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000115 DAVHIZ010000000
VERSION     DAVHIZ010000115.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1630)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.117"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..704)
                     /locus_tag="VVO18_002019"
     CDS             complement(<1..704)
                     /locus_tag="VVO18_002019"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000773447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587095.1"
                     /translation="MKLNKLNFLKENIRNLYSSGVIYLGLLISFIPPILVTFFILKTQ
                     GTSLGIKHISNFYAMLGMLMAVIHANRVISRDFSHNTVSLFYNQQKNRMIYVLSNFLY
                     AISVSIIYALNGIVLLVIVSKLGIPGDLGLDFIVAIVVNTILLVLFYFLLSYIFYLYK
                     LKSGLVFGILVALLLFIPNILNTMMMNTSNDLFIKAIELLPFYSLPVFVASNTMSISQ
                     YLVVITTIILLYFFTL"
     gene            complement(720..1511)
                     /locus_tag="VVO18_002020"
     CDS             complement(720..1511)
                     /locus_tag="VVO18_002020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812989.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587096.1"
                     /translation="MNFALNKGEIVGLAGRNGVGKSTLMKILVQNNQPTSGNIISSDN
                     VGYLIEEPKLFLSKTGLENLKYLSNLYGVDYNQEIFRSLIQELDLTQSINKKVKTYSL
                     GTKQKLALLLTLVTEPDILILDEPTNGLDIESSQIVLAVLKNLALHENVGILISSHKL
                     EDIEEICERVLFLENGLLTFQKVGKDSHNFLFEIAFSSATDRDIFITKQEFGDIVQEE
                     GLRITMSGNIQSSELFKFFNENSIKVVDFETKKETLKDIYLNRSK"
BASE COUNT          599 a          275 c          203 g          553 t
ORIGIN      
        1 ttgagagtga aaaagtacaa taaaatgatt gtagtgatta ccacaagata ctgactaata
       61 gacatcgtat ttgaagccac aaatacaggt aaagaataaa aaggaagaag ttcaattgct
      121 ttgataaaca aatcattact agtattcatc atcatcgtat ttaatatatt agggataaag
      181 agtagtaaag ctactaaaat accaaatacc aagccacttt tcaatttgta taaatagaaa
      241 atgtaagata atagaaaata aaacaggact aacaaaattg tattgactac aatagctact
      301 ataaaatcta atcctaaatc acctggaata cccaatttac ttactatgac tagtaacaca
      361 atgccattca aagcataaat aatggaaact gagatggcat atagaaaatt agacaagacg
      421 taaatcatcc gattcttctg ttgattataa aacaaactta ccgtattgtg ggaaaaatct
      481 ctactaatga ctcgattagc atgtataaca gccattaaca taccgagcat agcataaaag
      541 tttgaaatat gcttaatacc aagcgatgtc ccttgagtct ttagaataaa gaatgtaacc
      601 aatatcggcg gtataaacga gataagcaaa ccgagatata ttacgcctga tgaatataaa
      661 tttcttatat tttccttaag aaaattcaat ttatttaatt tcatgattat aaccttcctt
      721 tattttgaac gatttaggta aatatcttta agcgtctctt ttttagtttc aaaatcaact
      781 actttaatag agttttcgtt aaaaaattta aaaagctcac tactttgaat attcccagac
      841 atagtaattc tcaatccctc ttcctgaaca atatctccaa attcttgttt ggtaatgaaa
      901 atgtctctat ctgtagctga tgaaaaagct atctcaaaca agaaattatg actatctttt
      961 cctacttttt gaaatgtcaa aagcccgttc tccaagaaaa gaactctctc acaaatttct
     1021 tcaatgtctt ctaatttatg actcgatatt aaaattccca cattttcatg taaagctaaa
     1081 ttttttagaa ccgctaaaac tatttgtgat gattcaatat ctaaaccatt agtcggttca
     1141 tctaaaatca atatatcagg ttccgtaacg agagttagaa gcaaagctaa tttttgtttt
     1201 gtacccaaag aataggtctt tactttttta ttaatagact gagtcaaatc taactcttgg
     1261 atcaaacttc taaatatttc ttgattgtag tcaacaccat ataaatttga caaatatttt
     1321 aaattctcta aacctgtttt agataaaaat aattttggtt cttcgattaa atacccaaca
     1381 ttatcactgc ttataatatt acctgaagtc ggttgattat tctgaacaag aattttcatc
     1441 aacgtactct taccaactcc atttctccct gctagaccaa caatttcacc cttgttaagt
     1501 gcaaaattta tatctttgag aatgattgaa tgaccataat gcttacttac atttataact
     1561 tacatttttt attcctccat taatattcat ggtttgctct ttgattctta ttgagtttaa
     1621 aaagttgcac
//
LOCUS       DAVHIZ010000116         1554 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.118, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000116 DAVHIZ010000000
VERSION     DAVHIZ010000116.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1554)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.118"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..311
                     /locus_tag="VVO18_002021"
     CDS             <1..311
                     /locus_tag="VVO18_002021"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001081168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587097.1"
                     /translation="QVKVVDKLTDSESKKYGEYIDLYESCRQNNLSVLLNFLQNSDDK
                     RGVIASNSVRIMFESLDKADQIAALNICRNYVARENVLNKEDAEKLLNEIDKKLEISR
                     "
     gene            367..1062
                     /locus_tag="VVO18_002022"
     CDS             367..1062
                     /locus_tag="VVO18_002022"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001144916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5587098.1"
                     /translation="MPVNEYGQMIGESMEGYTPGALPSIDFLEGRYARIEALSVEKHA
                     EDLLAVYGPDTPREMWTYLFQEPVADMGELVSLLNQMLARKDRFYYAIIDKATGKALG
                     TFSLMRIDQNNRVIEVGAVTFSPELRGTRIGTEAQYLLARYIFEELNYRRYEWKCDAL
                     NLPSRRVAERLGFVYEGTFRQAVVYKGRTRDTDWLSMIDMDWPQVKDRLETWLRPENF
                     DKNGQQYKSLREL"
     gene            1074..1490
                     /locus_tag="VVO18_002023"
     CDS             1074..1490
                     /locus_tag="VVO18_002023"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001862593.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5587099.1"
                     /translation="MITIKKQEIVKLEDVLHLYQAVGWTNYTHQPEMLEHALSHSLVI
                     YLALDGDAVVGLIRLVGDGFSSVFVQDLIVLPIYQRQGIGSALMKEALKDYKDAYQVQ
                     LVTEETEKNVGFYRSMGFEILSTYNCIGMTWANREK"
BASE COUNT          483 a          238 c          378 g          455 t
ORIGIN      
        1 cgcaggtaaa agttgtagat aaacttactg attctgaatc gaaaaaatac ggtgaatata
       61 ttgatttgta cgaatcgtgt cgtcagaaca atttaagtgt tctacttaac tttcttcaaa
      121 attcggatga taaacgagga gttattgcta gtaactcagt gagaattatg tttgaatctt
      181 tggataaagc agaccaaatt gcggccctga atatttgtag aaactatgta gcacgagaaa
      241 atgttttaaa taaagaagat gcagaaaaat tgttaaatga aattgataaa aaacttgaaa
      301 ttagcagata ggacaattca aatagagttg agtaaaaagt ttgaaaagtg aaacaaggag
      361 aaagctatgc cagtaaatga atatggtcag atgattggtg agtcaatgga aggttataca
      421 cccggtgcac tgccttctat tgatttctta gaagggcgtt atgctaggat agaggctctc
      481 tcggtagaaa aacatgcgga ggatttgcta gctgtttatg gcccggatac tcctcgggag
      541 atgtggacct atctttttca ggagccagta gcagatatgg gggagctggt tagcctttta
      601 aatcagatgt tggctcgtaa ggaccgtttt tactatgcaa tcatagacaa ggcgactggt
      661 aaggctttgg gaactttttc tctcatgcgc attgaccaga ataaccgagt aatagaagtc
      721 ggagcagtca ctttttctcc agagctaagg ggtacacgga taggaactga ggctcagtat
      781 ctcctagctc gctatatttt tgaggagcta aactatcgtc gctacgagtg gaaatgcgat
      841 gccttaaatc tgccatccag acgagttgcg gagcgtttgg gatttgtcta tgaaggaacc
      901 ttccgccagg cggtggttta taaggggcgt acgagagata cggattggtt gtctatgatt
      961 gatatggact ggcctcaagt caaagatcgt ttggaaacat ggctgcgtcc tgaaaatttt
     1021 gataaaaatg gacagcagta caagagcttg agagaacttt aagaggtgtt gagatgatta
     1081 ctattaaaaa gcaagaaatt gtcaagctag aggatgtttt gcatctctat caggctgtcg
     1141 gttggacaaa ttatacccat caaccagaga tgctggagca tgccttatcg cattcattag
     1201 taatttatct ggcacttgat ggtgatgctg tggtgggctt gattcgtttg gttggagatg
     1261 gattctcatc agtttttgta caggatttga ttgttttacc aatctatcag cgtcaaggga
     1321 ttggtagtgc cctaatgaaa gaggccttaa aagattacaa agatgcttat caagtccagc
     1381 tggtgacaga agagacagaa aaaaacgtgg gattttatcg ttctatgggc tttgaaatct
     1441 tatccaccta taattgtata gggatgactt gggcgaatcg agaaaaataa caaaacttgt
     1501 tttttcttaa gcaaaattta aggatggtct agtattatat agtcattaaa taaa
//
LOCUS       DAVHIZ010000117         1528 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.119, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000117 DAVHIZ010000000
VERSION     DAVHIZ010000117.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1528)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.119"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            1..1041
                     /locus_tag="VVO18_002024"
                     /pseudo
     CDS             1..1041
                     /locus_tag="VVO18_002024"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436393.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
     gene            complement(1244..>1528)
                     /locus_tag="VVO18_002025"
     CDS             complement(1244..>1528)
                     /locus_tag="VVO18_002025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000458188.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEU5587100.1"
                     /translation="NNGSWYYLNANGSMATGWLQNNGSWYYLNANGSMATDWVKDGDT
                     WYYLEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDSYRVNANGEWVN"
BASE COUNT          463 a          331 c          257 g          477 t
ORIGIN      
        1 ggtcgctgaa acttctatcg tcaagaagaa tcaccaaatc cctcgtatca tcaaccaaaa
       61 gattgctcaa aagttaattg aaaagatttc tatgactgat attgcccatc aactttccat
      121 ctcaacttca actgttattc gtaagctcaa tgattttcac tttaaacatg atttttcgcg
      181 tcttcctgag attatgtctt gggatgagta tgcttttaca aagggaaaga tgagcttcat
      241 tgcgcaagat tttaacaatc tcaatatcat cactgttctt gaaggtagaa cacaagctgt
      301 catccgagat cactttctta aatatgatag agccgtccga tgtcgcgtca aaatcattac
      361 tatggatatg tttagccctt actatgactt agctaaacag cttcgctttc aaatttctag
      421 gctcaggctg aaacagtctc ctagactgtt tcactcccga atgctaaaat cgttcttgat
      481 cgctttcata ttgtacaaca tcttagccgt gctatgagtc gtgtgcgtgt tcaaatcatg
      541 aatcagtttc atcgaaaatc ccatgaatac aaggctatca agcgctactg gaagctcata
      601 caacaggata gtcgtaaact cagcgataaa catttttatc gccctacttt tcgtatgcat
      661 ttaaccaata aagagatttt agacaagctt ttgagctatt cacaagactt gaaacatcac
      721 tatcagctct atcaactctt gctgtttcac tttcagaata aggaaccgga gaaatttttc
      781 ggactcattg aggacaatct aaagcaggtt catcctcttt ttcagactgt ctttaaaacc
      841 tttctaaagg acaaagagaa aatcgtcaac gcccttcaac taccctattc aaacgccaaa
      901 ttggaagcga ccaataatct catcaaactt atcaagcgca atgcctttgg ttttcggaac
      961 tttgaaaact tcaaaaaacg gattttcatc gctctgaaca tcaaaaaaga aaggacgaaa
     1021 tttgtccttt ctcaagctta gctgacttca acccactaca gttgacaaag agtcaaaaaa
     1081 actccgtagt ctctagcgct ataaatccgg ctagagatta cagagttatt tttttatcta
     1141 aacttcctac aagggtatat tatctactga aaggatatgg tatttgtagg gaatacttta
     1201 aagagttctt acaggaagtc agtattaact agttatatta ggtttagttt acccattcac
     1261 cattggcatt gactctatag ctatctacag ttgtgttgac tgcaagggca cctgagccat
     1321 tgacatagta ccatttatct gatactttga accattggct tgctttcata gcacctgatg
     1381 cttcaagata gtaccaggta tctccatctt tcacccaatc tgtcgccatt gaaccattag
     1441 cgtttaggta gtaccatgag ccattgtttt ggagccatcc tgtcgccatt gaaccattag
     1501 cgtttaggta gtaccatgag ccattgtt
//
LOCUS       DAVHIZ010000118         1515 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.120, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000118 DAVHIZ010000000
VERSION     DAVHIZ010000118.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1515)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.120"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            1..891
                     /locus_tag="VVO18_002026"
                     /pseudo
     CDS             1..891
                     /locus_tag="VVO18_002026"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611577.1"
                     /note="frameshifted; internal stop; incomplete; missing
                     N-terminus; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS630 family transposase"
     gene            complement(924..1264)
                     /gene="tnpB"
                     /locus_tag="VVO18_002027"
                     /pseudo
     CDS             complement(924..1264)
                     /gene="tnpB"
                     /locus_tag="VVO18_002027"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001849103.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="IS66 family insertion sequence element accessory
                     protein TnpB"
BASE COUNT          478 a          275 c          311 g          451 t
ORIGIN      
        1 caaacaacga tttggcgaaa tgtaaaaaaa tatgaggagt tcggactcga ctctctcctt
       61 caagaaacac gtggtggtcg taaccatgca tatatgacgg ttggggaaga gaaagccttt
      121 cttgcccgtc atttgaaggc tgcagaggca ggagaatttg ttacaattga tgccttattt
      181 caggcttata aaaaggagtt aggtcgttcc tacacacgtg atgccttcta tcaactgttg
      241 aagcgccatg gttggcgaaa tattatgcca cgtccagaac atcctaagaa agcagacgct
      301 caaaccattg tcgcgtctaa aaataaaatc tcaattcaag aagaaaagaa agcgttttaa
      361 aaccagtaga cgttttcata aggttcgctt gatgtaccaa gatgaggctg gcttcggtag
      421 aatcagtaaa ctgggatctt gttggtctcc aataggagta ggtccacatg tccatagtca
      481 ctatatacga gaatttcgct attgttatgg acccatacag gcgaatcatt tttcttaata
      541 gctggtggat gtaatactga gtggatgaac gtctttttag aagagctttc acaagcttat
      601 ccagatgatt atcttttatt cgttatggac aatgctatat ggcataaatc aagtacctta
      661 aagattccga ctaatattgg ctttgcattt attcctccgt acacaccaga gatgaacccc
      721 attgaacaag tgtggaaaga gattcgtaaa cgtggattta aaaataaagc ctttcaaact
      781 ttggaagatg tcatgaatca actttaagat atcatacaag gactggagaa ggaggtgata
      841 aagcccatcg ttaatcggag atggactaga atgctttttg aaagcagatg agtataaaaa
      901 gaaagtcctc atttcaatag aaatcacgac tttctgatgg atttattttt ggagtgatag
      961 aaaagccctt cataagccag tctacttgtt caggtgtgag agctttgaca tccttttctg
     1021 tactgggcca agtcagtctg ccgttctcaa agcgtttata tagtagccaa aatccttgac
     1081 catcccagta aagggcttta aagcggtctt tacgtccacc acaaaagaga aagacttgac
     1141 cggagaaagg atccaattca aagtgggttt taactacata ggctaatgag tctattccct
     1201 gcctcatatc tatcttgcta caaacaaggt gaacttgacc taaatcactt agttgaatta
     1261 tcatagtaca atacctttcc tccgataatt attttttatc tagtatactg gaagttgggg
     1321 aattaggata gataccttgt tatgacgcgc ttacgtaact tgtaactagc tgcctagttt
     1381 gatctttgct tcttcattga ttagcagtag atttcaaaat gataaaaacg tataatagta
     1441 ggtgtagtgt actgcccccc aaaaagttag acagaaaaaa tctaactttt tggggtgttt
     1501 ttattatgaa attaa
//
LOCUS       DAVHIZ010000119         1416 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.121, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000119 DAVHIZ010000000
VERSION     DAVHIZ010000119.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1416)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.121"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..1408)
                     /locus_tag="VVO18_002028"
     CDS             complement(<1..1408)
                     /locus_tag="VVO18_002028"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398455.1"
                     /note="The YSIRK form of extended signal peptide directs
                     nascent proteins to the cross-wall site, while signal
                     peptides lacking YSIRK direct proteins instead to the cell
                     pole. A large fraction of YSIRK proteins are surface
                     proteins anchored by sortase-mediated processing of a
                     C-terminal LPXTG motif; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YSIRK-type signal peptide-containing protein"
                     /protein_id="HEU5587101.1"
                     /translation="MKSFQQNEVFSIRKSKVGVCSVLLAVLFIGTQSVLANEVVGETS
                     SSKDNMQMNSLLSSTSTSLSAEPHSDTLSLDNNSSLSTDNNGGVSINQNKPDITNDTM
                     MGNISGMEVNTILSTNLNEHVALNVKDYGAIGDGVNDDRQAIQDAIDAAAQGLGGGNV
                     YFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWG
                     PTEDISYSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQG
                     HAIQIAGSKNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKK
                     SENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTG
                     FTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIA
                     DPKTKAIRVAKDSAEYLGK"
BASE COUNT          428 a          282 c          196 g          510 t
ORIGIN      
        1 cttttcctaa atattctgca ctatcttttg caactcgtat cgcttttgtt ttaggatcgg
       61 caatattaaa tatattttcg gcgataacca cctgtttatt taaatctaat aggtctttag
      121 tgtttttata gctataagca tttactaaag ctgctccgct ttctcgataa tgtacactct
      181 ctcctttaac tttcttatca aagcgatttc ctttgattaa tacatcagtg aatcctgtaa
      241 aacgtacacc tgcatacatc atgttatcaa aatgattatt taaaatttta atattagagg
      301 ggttctgtgt cgacaatgtt tgatagtgtg tgccaattgc tgttactaat tccccagatt
      361 tatcactttt gccaaaatag gaattttgaa tagtcacatt ttcagatttt ttcccatcat
      421 cattcaaggc ataaggaaaa ccttttctag ttaatggttc aatctgaatg ctctccttac
      481 ttatgatttg cccatccttc atcgttttgg gtaaggcttg cccaagaaaa cgagaattat
      541 caactaatac atttttcgaa cctgcaattt gaatagcatg cccttgataa ctatccttga
      601 atgttacatt ttttatagtt acgttatttg aattcccaat agcaaatgca cctgaagaat
      661 ttataagtgg tagatttttt gctttagttc cttcttcatt caaagcaccg ttcatatcaa
      721 tagtaccacc agaataacta atatcttctg ttgggcccca ttctacttgc gcaccatcat
      781 ccgtaaataa acctgtcata aaaacaatag aagggtgatt cttaatattt ataccattta
      841 gaatggtagc tttctcattc aattctaagt gtgtatgact ttttaaaaaa acaatttctt
      901 ttactaaata agttccttcc ggaaaatata catttcctcc acctagccct tgagctgcag
      961 catctattgc atcttgaatt gcttgtcgat catcattaac cccgtcacct attgctccat
     1021 aatctttaac attcaaagct acgtgttcgt tcagattagt acttaaaata gtattcactt
     1081 ccatcccaga gatgttaccc atcatagtat catttgttat atcaggttta ttttgattaa
     1141 tactcactcc tccattatta tcagtactta aacttgaatt gttatcaaga ctgagagtat
     1201 cagaatgggg ttccgcagat aatgatgtag atgtgctact caacaaagag ttcatttgca
     1261 tattatcttt agacgaagaa gtttcaccaa ctacttcatt agctaaaaca ctttgtgttc
     1321 caataaataa aaccgctaag agaactgagc aaactcccac cttagactta cgaatagaga
     1381 aaacctcatt ttgttgaaaa gatttcatat tagcct
//
LOCUS       DAVHIZ010000120         1415 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.122, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000120 DAVHIZ010000000
VERSION     DAVHIZ010000120.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1415)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.122"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..143
                     /locus_tag="VVO18_002029"
     CDS             <1..143
                     /locus_tag="VVO18_002029"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000968321.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587102.1"
                     /translation="SIDLTKDEFYKLIKTLNDEEIRLNIMEILEERIDDNVEKSSKDE
                     IT"
     gene            457..>1415
                     /locus_tag="VVO18_002030"
     CDS             457..>1415
                     /locus_tag="VVO18_002030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019213953.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="HEU5587103.1"
                     /translation="MADSFHFSVNIISRGKGKSAVASAAYISGEKIKNEWDGVTHDYT
                     RKEKILVKNIILPDHIPKEFNDRSTLWNKVEMAEKNSNAQLARQFIIGLPKELSLSEN
                     KNLVERYIKENLTSQGMIVDYAIHDESQDKNGNIHCHIMTIMRPINEKGEFLAKSKKE
                     YILDEKGEKVLNKNGKPKTRKVELTTWNDTGNVEKWRENFSDLCNKYLERAGAEKRVD
                     HRSFKRQNSDYLPTIHLGSAASAMERKGIETDKGNYNREIRKYNQLVKTIKEEIKTLK
                     GWIGNLLDNLSTAYEKFKDIERDKVIDNPKLFNLTNYLLTYSE"
BASE COUNT          655 a          182 c          242 g          336 t
ORIGIN      
        1 aaagtattga tttaacaaaa gatgaatttt ataagttaat aaaaacgtta aatgatgaag
       61 aaataagatt aaacataatg gaaattttag aagaaagaat agatgataat gtagaaaaat
      121 catctaaaga tgaaataaca taattgtccc ttggttacaa gggcgcaatt atacacccta
      181 aagggtgctt gcgtcctgcg gagtcaaacc cttgcaggga gcaacaacca ttcgcttttt
      241 aaaagtcaag ggtaaataaa ctcgctaagg ctcgcccttg acttttaaaa tttgaaatga
      301 aagtaacaat taagccgaca tactgaaaca acaaaaatta attcagtagt cggctttttt
      361 aattctatca tttcaaaacg ctcattcaca aagaggatat aaaaaaacta ttaagcctcc
      421 acctaaaaca acaaagaaag aaaggaagtg ataaaaatgg cagacagttt tcatttttca
      481 gtaaacataa tatcaagagg aaaaggcaaa agtgcagtag caagtgcagc atatataagt
      541 ggagaaaaaa taaaaaatga atgggacgga gtaacccatg actacacaag aaaagaaaaa
      601 atattagtaa aaaatataat attgcctgat catataccaa aagaatttaa tgataggtct
      661 accttatgga ataaagtaga aatggcagaa aaaaattcta atgcacaact agcaagacaa
      721 ttcataatag gactaccaaa agagttatct ttaagtgaaa ataaaaacct ggttgaaaga
      781 tatataaaag aaaatttaac atcacaagga atgatagtag attatgcaat tcatgatgag
      841 agtcaagata aaaatggaaa tatccattgt catataatga ccataatgcg accaataaac
      901 gaaaaaggag agttcttagc caagtcaaaa aaagaatata tcctagatga aaaaggagaa
      961 aaagtattaa acaaaaatgg aaaaccaaag acaagaaaag tagaactaac aacctggaac
     1021 gatacaggca atgtagaaaa atggagagaa aatttttcag atctttgtaa caaatattta
     1081 gaaagagcag gagcagaaaa aagagtagac cataggagtt ttaaaagaca aaattcagat
     1141 tatctaccga caatccattt aggatcagca gcaagtgcaa tggaaagaaa gggaatagaa
     1201 actgacaagg gaaactataa tagagaaata agaaaatata atcaacttgt aaaaacaata
     1261 aaagaagaga taaaaacatt aaagggttgg ataggaaatt tattagataa cttatctact
     1321 gcttatgaaa aatttaagga tatcgaaaga gataaggtaa tagacaaccc taaacttttt
     1381 aatctaacaa attatctatt aacttattca gaaat
//
LOCUS       DAVHIZ010000121         1415 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.123, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000121 DAVHIZ010000000
VERSION     DAVHIZ010000121.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1415)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.123"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            132..929
                     /locus_tag="VVO18_002031"
                     /pseudo
     CDS             132..929
                     /locus_tag="VVO18_002031"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000436304.1"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(964..1173)
                     /locus_tag="VVO18_002032"
                     /pseudo
     CDS             complement(964..1173)
                     /locus_tag="VVO18_002032"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611222.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
     gene            complement(1339..1412)
                     /locus_tag="VVO18_002033"
     tRNA            complement(1339..1412)
                     /locus_tag="VVO18_002033"
                     /product="tRNA-Asn"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:complement(1376..1378),aa:Asn,seq:gtt)
BASE COUNT          470 a          284 c          221 g          440 t
ORIGIN      
        1 tttgctacct aaatttcaaa caattaaagt tctaaaaaga ccgccttaaa acttttgggt
       61 aaatcctatt agaactataa tatttttata taggtattat ggttctgatt ttctagtata
      121 aaaaaattca aactagaatt cttcttagaa aaggccgttt taagtgctat cattgctcaa
      181 aaatggaggt tgctgagact tctatcgtca agaagaatca tcaaattcct tgtatcatca
      241 accaaaagat tgctcagaag ctaattgaaa agacttctat gaccgacatt gatcatcagt
      301 tgtctatttc aacttcaact gtcattcgca agatcaatga ttttcacttt gagcatgatt
      361 tttcgcgtct tcctgagatt atgtcctagg acgttgaaac agtctgggga gtgactgttt
      421 caatcgggag atagagatga gctttattgc tcaggacttt gataagctca atatcataac
      481 tgttcttgag agcagaacac aagccatcat ccgaaatccc atgaatacaa ggctatcaag
      541 cgatactgaa agctcattca acaagatagt cagaaactga gtgataaacg attttatcgc
      601 cctacttttc gtatgcactt gactaataaa gaaattctag ataaactttt gagctattcc
      661 gaagacttga aacaccacta taatctctat cagctcttgc ttttccacct ctttttcaga
      721 ctctgtttaa aaccttcctc aaagataaag agaaaatcgt caacgccctt caattacctt
      781 attccaacgc caaactggaa gccaccaata atctcatcaa acttatcaag cacaatgcct
      841 ttggttttag gaactttgaa aacttcaaaa aagaaaggac gaaatttgtc ctttctagat
      901 cttcgctttc ttcaacccac tacagttgac aaagaaccga aaaatgtctc gcctctaata
      961 tagtcaattg aaacaagaac aagacaaaag agcctcgtaa aaggtattgc aacttggtaa
     1021 tacctttttg aggtgctttt tgatatgagc ccatgttttc tcaataggat tgtactcagg
     1081 tgagtaggga ggaagatgta aaagtttatg cccaaactct tcgcataaaa gttctagctt
     1141 ccccattcta tggaatcttg cattgtccat aatatagtag attgaaacta gaatagtaca
     1201 cctctacttc taaaacattg ttagaattcg attttactgt cctaatcgat ttgtcctatt
     1261 cttatttcat tttactataa cacgaaatag attattatta cataacaaaa aagaggtcta
     1321 aacctcttaa ctcaattact ccgccagtag gactcgaacc tacgacatca tgattaacag
     1381 tcatgcgcta ctaccaactg agctatggcg gatta
//
LOCUS       DAVHIZ010000122         1394 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.124, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000122 DAVHIZ010000000
VERSION     DAVHIZ010000122.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1394)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.124"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            208..900
                     /locus_tag="VVO18_002034"
     CDS             208..900
                     /locus_tag="VVO18_002034"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001846497.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="G5 domain-containing protein"
                     /protein_id="HEU5587104.1"
                     /translation="MNTSFVHAVDGIQYVRDDTRDKEEGIEYDDADNGDIIVKVATKP
                     KVVIKKISSTRIRYEKDETKDRSENPVTIDGEDGYVTRTRTYDVNPETGHVTEQVTVD
                     RKEATDTVIKVPAKSKVEEVLVPCATKYEADNDLSAGQEQEITLGKNGKTVTTITYDV
                     DGKSGQVTESTLSQKEDSQTRVVKKGTKPQVLVQEIPIETEYLDGSTLDKSQEVEEVG
                     EIGKLLLLQSIL"
     gene            954..1343
                     /locus_tag="VVO18_002035"
     CDS             954..1343
                     /locus_tag="VVO18_002035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240828.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="N-acetylmuramoyl-L-alanine amidase family
                     protein"
                     /protein_id="HEU5587105.1"
                     /translation="MVKRRIRRGTREPEKVVVPEQSSIPSYPVSVTSNQGTDVAVEPA
                     KAVAPTTGWKQENGMWYFYNTDGSMATGWVQVNGSWYYLNSNGSMKVNQWFQVGGKWY
                     YVNTSGELAVNTSIDGYRVNDNGEWVR"
BASE COUNT          511 a          199 c          307 g          377 t
ORIGIN      
        1 agttaaagtg ttagttcaat aatcaatata tcattctaag tctatttgat atataaaata
       61 tattgtttaa cgtttgatag aaaagatgct atactagaag taggatgtaa tggcaaaatc
      121 taatactaat aagcgctatg cattacgtaa actcggaaag atttttggtt ctgcggtaat
      181 cgggctaact ttatttttag gaggaatctg aatacaagtt ttgttcatgc tgttgatggg
      241 attcaatatg tcagagatga tactagagat aaagaagagg gaatagagta tgatgacgct
      301 gacaatgggg atattattgt aaaagtagcg actaaaccta aggtagtaat caagaaaatt
      361 tcaagtacgc gaattcgtta tgaaaaagat gaaacaaaag accgtagtga aaatcctgtt
      421 acaattgatg gagaggatgg ctatgtaact aggacaagga cctacgatgt taatccagag
      481 actggtcatg ttaccgaaca ggttactgtt gatagaaaag aagccacgga tacagttatc
      541 aaagttccag ctaaaagcaa ggttgaagaa gttcttgttc catgtgctac taaatatgaa
      601 gcagacaatg acctttctgc aggacaggag caagagatta ctctaggaaa gaatgggaaa
      661 acagttacaa cgataactta tgatgtagat ggaaagagtg gacaagtaac tgagagtact
      721 ttaagtcaaa aagaagactc tcaaacaaga gttgttaaaa aaggaaccaa gccccaagtt
      781 cttgtccaag aaattccaat cgaaacagaa tatctcgatg gctcaactct tgataaaagt
      841 caagaagtag aagaagtagg agaaattggt aaattactct tactacaatc tatactgtag
      901 atgaacgtga tggaacaatt gaagaaacta cttctcgtca aattactaaa gagatggtaa
      961 aaagacgtat aaggagaggg acgagagaac ctgaaaaagt tgttgttcct gagcaatcat
     1021 ctattccttc gtatcctgta tctgttacat ctaaccaagg aacagatgta gcagtagaac
     1081 cagctaaagc agttgctcca acaacaggct ggaaacaaga aaatggtatg tggtattttt
     1141 ataatactga tggttccatg gcaacaggtt gggtacaagt taatggttca tggtactacc
     1201 tcaacagcaa cggttctatg aaagtcaatc aatggttcca agttggtggt aaatggtatt
     1261 atgtaaatac atcgggtgag ttagcggtca atacaagtat agatggctat agagtcaatg
     1321 ataatggtga atgggtgcgt taacagattc ctccctgcga caaaattgat aatagtatgt
     1381 ctgaatatat aatt
//
LOCUS       DAVHIZ010000123         1346 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.125, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000123 DAVHIZ010000000
VERSION     DAVHIZ010000123.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1346)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1346)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.125"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..545
                     /locus_tag="VVO18_002036"
     CDS             <1..545
                     /locus_tag="VVO18_002036"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001840385.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU5587106.1"
                     /translation="LDVVGVQDFKKEFCIPNNKKIICYVERLDPEKRPDRFLEFAEKL
                     FLVREDVIFIMAGNGSMWAALKEKICHLKCRDNFRLLGEIYPATIVYQISDLLYIPSD
                     TEGIPMCVLESMSQGTPVLASNVGGLSEIIEHRVDGFLFEKEDVEGVCACANFLLNDS
                     EYLKYIGENSKSKIRKHESI"
     gene            569..>1346
                     /locus_tag="VVO18_002037"
     CDS             569..>1346
                     /locus_tag="VVO18_002037"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="HEU5587107.1"
                     /translation="MDRNIDQELVSIIIPTHNRYESLIRAVKSCLHQSYKNIEVIIID
                     DNYSNVNLRNKIIHQFGYTNHRIKLILSNEDLGATNARNIGIKNSRGKYISFLDDDDE
                     YMPDRILKLMACFKKSRMKNLALVYSYGIIIYPNGTREEEKTDFVGNPLFVQMVHNIA
                     GTSFWLCKKEVLELINGFEKIDSHQDGVVLLKLLAQGYQIDIVREFLVNYYAHSKENG
                     ITGVTQKTINADEEYYNYCRKYFNLLSFNERILVTKKYYSL"
BASE COUNT          498 a          129 c          270 g          449 t
ORIGIN      
        1 atttagatgt agtaggtgtt caagacttta aaaaagaatt ttgtattcca aataacaaaa
       61 aaatcatttg ttatgttgaa aggttggatc cagaaaaaag gccggataga ttccttgaat
      121 ttgcagaaaa attattttta gtcagagaag atgtgatttt tattatggct ggaaatggta
      181 gtatgtgggc tgctttgaaa gaaaaaattt gccatttgaa atgtagagat aatttcaggt
      241 tacttggtga aatctatcca gctactatag tttaccaaat atcggattta ttgtatattc
      301 cttctgatac agaaggaata cctatgtgtg ttttagagtc aatgtcacaa ggaactccgg
      361 ttttagctag taatgttggc gggttaagtg aaattattga acatagggtt gatggatttt
      421 tatttgagaa ggaagatgtt gagggagtgt gtgcttgtgc taatttttta ctcaatgatt
      481 ctgagtattt gaaatatata ggtgagaata gtaaatcaaa aataagaaaa catgagagta
      541 tatgatgaat tattagagaa gagtagtcat ggataggaat atagatcaag aattagtaag
      601 tattataata ccaacacata ataggtatga atctctgatt agagctgtga aaagttgttt
      661 acatcaaagt tataaaaata tcgaagttat aattattgat gataattata gtaatgtaaa
      721 tttaagaaat aaaattatcc atcaatttgg ctataccaat catagaatta agttaatttt
      781 aagtaatgaa gatttaggtg caactaatgc cagaaacata ggtatcaaaa attctagagg
      841 taagtatata tcatttttag acgatgatga tgaatatatg ccagatcgaa ttttaaagtt
      901 gatggcttgt tttaaaaaga gtagaatgaa gaatttagct ttagtttata gttatggaat
      961 aataatttat ccaaatggta cacgagaaga ggagaagacc gattttgttg gaaatccctt
     1021 gtttgttcaa atggttcaca atatagcagg tacgtcattt tggttgtgta aaaaagaggt
     1081 gctagaatta attaatggtt ttgagaaaat agattcacat caggacggtg ttgttttatt
     1141 aaaactactt gctcaaggat accaaattga tatagtgcga gaattcttgg tgaattacta
     1201 cgctcacagt aaagaaaacg gtatcactgg agtgacacaa aaaacaatta atgcagatga
     1261 agaatattat aattactgta ggaaatattt taatttattg agtttcaacg agagaatatt
     1321 ggttacaaag aaatattatt ctttaa
//
LOCUS       DAVHIZ010000124         1331 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.126, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000124 DAVHIZ010000000
VERSION     DAVHIZ010000124.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1331)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1331)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.126"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..829
                     /locus_tag="VVO18_002038"
     CDS             <1..829
                     /locus_tag="VVO18_002038"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000161411.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="DegV family protein"
                     /protein_id="HEU5587108.1"
                     /translation="KIVTDSSVTIEPELVKQLDITIVPLSVMIDNVVYSDADLKEEGK
                     FLQLMQESKNLPKTSQPPVGVFAEIFEDLCKDGGQILAIHMSHALSGTVEAARQGASL
                     STADVTVVDSSFTDQALKFQVVEAAKLAQEGKDMEAILCHVEEVKNHTELYIGVSTLE
                     NLVKGGRISRVTGLLSSLLNIRVVMQMKDHELQPMVKGRGTKTFKKWLDELITSLSER
                     AVAEIGISYSGSDDWAKEMKESLQAYVEKPISVLETGSIIQTHTGENAWAILIRYHS"
     gene            936..1211
                     /locus_tag="VVO18_002039"
     CDS             936..1211
                     /locus_tag="VVO18_002039"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="HU family DNA-binding protein"
                     /protein_id="HEU5587109.1"
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVEAVFAAVADYLAAGEKVQ
                     LIGFGNFEVRERAERKGRNPQTGKEMTIAASKVPAFKAGKALKDAVK"
BASE COUNT          436 a          205 c          288 g          402 t
ORIGIN      
        1 taagattgta accgattcat ctgttactat tgaacctgaa ctagtaaagc aattagatat
       61 tacaattgtt ccattatctg taatgattga taatgttgtt tattctgatg cggatttgaa
      121 agaagaaggt aaatttcttc agttgatgca agaaagtaag aatcttccga aaacaagtca
      181 gccacctgta ggtgtctttg ctgagatttt tgaagaccta tgcaaagatg gtggccagat
      241 tcttgctatt catatgtccc atgctctttc gggtacggta gaagcagcac gccaaggtgc
      301 tagcctatct actgcagatg tgactgttgt tgatagttcc ttcactgacc aagccctgaa
      361 attccaagtt gttgaggctg cgaagttagc tcaagaaggt aaagatatgg aggcaatttt
      421 atgtcatgta gaagaggtta aaaaccatac agagctttat attggtgttt caactttgga
      481 aaatcttgtc aaaggtggac gaattagccg tgtaactggc ttgttgagct ctcttctcaa
      541 tatccgtgtt gtcatgcaaa tgaaagacca tgaattgcag ccaatggtta aaggtcgtgg
      601 aactaaaaca tttaaaaaat ggttagatga gttgataaca tcgctttctg aacgtgctgt
      661 agcagagatt ggaatttcat attctggtag tgatgattgg gcaaaagaga tgaaagaaag
      721 cttacaagct tatgttgaaa agccaatttc tgttttggaa acgggttcca ttattcaaac
      781 tcacacgggt gagaacgctt gggctatttt gatacgttac cactcctaaa aaaataaata
      841 aaatgggaag aaatagcgtt tttaacttga cctaaaaggg attttaggat atgattatat
      901 ttgttaatta gaaattattt ggaggaatca ttaacatggc aaacaaacaa gatttgatcg
      961 ctaaagtagc agaagctaca gaattgacta agaaagactc agcagcagca gttgaagctg
     1021 tatttgcagc agtagctgac tatcttgcag ctggtgaaaa agttcagttg atcggttttg
     1081 gtaactttga agttcgtgag cgcgcagaac gtaaaggtcg caacccacaa actggtaaag
     1141 aaatgacaat tgcagcttct aaagtaccag cattcaaagc tggtaaagct cttaaagacg
     1201 ctgttaaata atcagtcttt aaaaagccta ttgtatcaag ctttctagct tggtcagtag
     1261 gctttttaat tatgaaatct agtaataaat agagttaaaa agttgaatgt tccgaaaata
     1321 ttgtatatat a
//
LOCUS       DAVHIZ010000125         1229 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.127, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000125 DAVHIZ010000000
VERSION     DAVHIZ010000125.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1229)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.127"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            148..924
                     /locus_tag="VVO18_002040"
     CDS             148..924
                     /locus_tag="VVO18_002040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000406168.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="HEU5587110.1"
                     /translation="MEISKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQ
                     RMKPEKMKDAQREKFTLVGEEKTVEEIITEVLKDKEFYEESGGGLTLSGGEIFAQFEF
                     AKAILKSAKEHHIHTAIETTAFVDHEKFIDLIQYVDFIYTDLKHYNSIKHKKVTGVFN
                     QMIIKNIHYAFSQNKTIVLRIPVIPNFNNSLEDAEKFATLFNSLNIDQVQLLPFHQFG
                     ENKYRLLNRKYEMDEINALHPEDLIDYQKVFLNHHINCYF"
     gene            999..1196
                     /locus_tag="VVO18_002041"
     CDS             999..1196
                     /locus_tag="VVO18_002041"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007520791.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AraC family transcriptional regulator"
                     /protein_id="HEU5587111.1"
                     /translation="MTLNEYILQYRLKQAIDKMAESPNSPLSAISDQVGFSDYKYFAK
                     VFKKYLHISPKKLKSLGRIVK"
BASE COUNT          437 a          208 c          174 g          410 t
ORIGIN      
        1 taataatttg ttccaatctt ttcattttac acctccgttt tattctacca aaataaaaag
       61 caaaaaaaca acaaattaac ctttcgttcg taattgtttt tctttcgttt ttgtgatagg
      121 atagacttat gaagaggagg aactcttatg gaaatatcta aaggaattat ttttaatatt
      181 caacactttt caattcatga cggcccgggt attcgtacaa ctgttttttt aaaaggatgt
      241 cctctgcgct gtccatggtg ttctaatcct gaatctcaaa gaatgaaacc tgaaaaaatg
      301 aaagatgctc aacgagagaa attcacctta gtcggtgaag aaaagactgt agaagaaatt
      361 attacagagg tattaaaaga caaagaattt tacgaagaat ccggtggagg tttaacttta
      421 tcaggaggtg aaatatttgc tcagtttgaa tttgctaaag ccatcttaaa atcagctaaa
      481 gaacatcaca tacacactgc cattgaaact actgcctttg ttgatcatga aaaatttatc
      541 gatttaattc aatatgtgga ttttatctac acagacctaa aacattataa ttctataaaa
      601 cataaaaaag tgactggggt ttttaatcaa atgattatta aaaacattca ttatgctttt
      661 tctcaaaata aaactatcgt tttaagaatc ccagttattc ctaattttaa caatagttta
      721 gaggatgcag aaaaattcgc tactctattt aactcattaa atatcgacca agttcaacta
      781 ctcccttttc atcaatttgg tgaaaacaaa tatcgtttat taaatcggaa atatgaaatg
      841 gatgaaatca acgcacttca tcctgaagat cttattgatt atcaaaaggt atttctgaac
      901 caccatatta attgttattt ctagtttatt tccttgaaat gctctagcta tttgcagata
      961 acaagcatct atataaggtt atcaaagaag acttccccat gactctaaat gaatatatct
     1021 tacaatatcg cctgaaacaa gctatagata agatggctga atctcccaac tcccctttaa
     1081 gcgctatctc tgaccaagtt ggattttcag actataaata ttttgccaaa gtatttaaaa
     1141 agtatctcca tatttcccca aagaaattga aatcactcgg aagaatagtc aaataggcta
     1201 ttcttctttt tgtagagaat tttactcta
//
LOCUS       DAVHIZ010000126         1197 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.128, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000126 DAVHIZ010000000
VERSION     DAVHIZ010000126.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1197)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.128"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..>1197
                     /gene="phtD"
                     /locus_tag="VVO18_002042"
     CDS             <1..>1197
                     /gene="phtD"
                     /locus_tag="VVO18_002042"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000700388.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="pneumococcal histidine triad protein PhtD"
                     /protein_id="HEU5587112.1"
                     /translation="LIFDPAQITSRTARGVAVPHGNHYHFIPYSQMSELEKRIARIIP
                     LRYRSNHWVPDSRPEQPSPQSTPEPSPSLQPAPNPQPAPSNPIDEKLVKEAVRKVGDG
                     YVFEENGVSRYIPAKDLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAY
                     DLLARIHQDLLDNKGRQVDFEALDNLLERLKDVSSDKVKLVDDILAFLAPIRHPERLG
                     KPNAQITYTDDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDS
                     LSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNL
                     QYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERP
                     HSDNGF"
BASE COUNT          379 a          262 c          251 g          305 t
ORIGIN      
        1 gccttatttt cgacccagcg caaatcacaa gtcgaaccgc cagaggtgta gctgtccctc
       61 atggtaacca ttaccacttt atcccttact ctcaaatgtc tgaattggaa aaacgaattg
      121 ctcgtattat tccccttcgt tatcgttcaa accattgggt accagattca agaccagaac
      181 aaccaagtcc acaatcgact ccggaaccta gtccaagtct gcaacctgca ccaaatcctc
      241 aaccagctcc aagcaatcca attgatgaga aattggtcaa agaagctgtt cgaaaagtag
      301 gcgatggtta tgtctttgag gagaatggag tttctcgtta tatcccagcc aaggatcttt
      361 cagcagaaac agcagcaggc attgatagca aactggccaa gcaggaaagt ttatctcata
      421 agctaggagc taagaaaact gacctcccat ctagtgatcg agaattttac aataaggctt
      481 atgacttact agcaagaatt caccaagatt tacttgataa taaaggtcga caagttgatt
      541 ttgaggcttt ggataacctg ttggaacgac tcaaggatgt ctcaagtgat aaagtcaagt
      601 tagtggatga tattcttgcc ttcttagctc cgattcgtca tccagaacgt ttaggaaaac
      661 caaatgcgca aattacctac actgatgatg agattcaagt agccaagttg gcaggcaagt
      721 acacaacaga agacggttat atctttgatc ctcgtgatat aaccagtgat gagggggatg
      781 cctatgtaac tccacatatg acccatagcc actggattaa aaaagatagt ttgtctgaag
      841 ctgagagagc ggcagcccag gcttatgcta aagagaaagg tttgacccct ccttcgacag
      901 accatcagga ttcaggaaat actgaggcaa aaggagcaga agctatctac aaccgcgtga
      961 aagcagctaa gaaggtgcca cttgatcgca tgccttacaa tcttcaatat actgtagaag
     1021 tcaaaaacgg tagtttaatc atacctcatt atgaccatta ccataacatc aaatttgagt
     1081 ggtttgacga aggcctttat gaggcaccta aggggtatac tcttgaggat cttttggcga
     1141 ctgtcaagta ctatgtcgaa catccaaacg aacgtccgca ttcagataat ggttttg
//
LOCUS       DAVHIZ010000127         1146 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.129, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000127 DAVHIZ010000000
VERSION     DAVHIZ010000127.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1146)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1146)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.129"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..1119)
                     /locus_tag="VVO18_002043"
     rRNA            complement(<1..1119)
                     /locus_tag="VVO18_002043"
                     /product="16S ribosomal RNA"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00177"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /db_xref="RFAM:RF00177"
BASE COUNT          252 a          361 c          235 g          298 t
ORIGIN      
        1 gggttgcgct cgttgcggga cttaacccaa catctcacga cacgagctga cgacaaccat
       61 gcaccacctg tcacctctgt cccgaaggaa aactctatct ctagagcggt cagagggatg
      121 tcaagacctg gtaaggttct tcgcgttgct tcgaattaaa ccacatgctc caccgcttgt
      181 gcgggccccc gtcaattcct ttgagtttca accttgcggt cgtactcccc aggcggagtg
      241 cttaatgcgt tagctacggc actaaacccc ggaaagggtc taacacctag cactcatcgt
      301 ttacagcgtg gactaccagg gtatctaatc ctgtttgctc cccacgcttt cgagcctcag
      361 cgtcagttac aagccagaga gccgctttcg ccaccggtgt tcctccatat atctacgcat
      421 ttcaccgcta cacatggaat tccactctcc cctcttgcac tcaagttaaa cagtttccaa
      481 agcctactat ggttaagcca cagcctttaa cttcagactt atctaaccgc ctgcgctcgc
      541 tttacgccca ataaatccgg acaacgctcg ggacctacgt attaccgcgg ctgctggcac
      601 gtagttagcc gtccctttct ggtaagatac cgtcacagtg tgaactttcc actctcacac
      661 tcgttcttct cttacaacag agctttacga tccgaaaacc ttcttcactc acgcggcgtt
      721 gctcggtcag acttccgtcc attgccgaag attccctact gctgcctccc gtaggagtct
      781 gggccgtgtc tcagtcccag tgtggccgat caccctctca ggtcggctat gtatcgtcgc
      841 cttggtgagc cgttacccca ccaactagct aatacaacgc aggtccatct ggtagtgatg
      901 caagtgcacc ttttaagcaa atgtcatgca acatccactc ttatgcggta ttagctatcg
      961 tttccaatag ttatcccccg ctaccaggca ggttacctac gcgttactca cccgttcgca
     1021 actcatccag agaagcaagc tcctccttca gcgttctact tgcatgtatt aggcacgccg
     1081 ccagcgttcg tcctgagcca ggatcaaact ctcattaaaa gtttgagttc tcactcattt
     1141 ctgtca
//
LOCUS       DAVHIZ010000128         1074 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.130, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000128 DAVHIZ010000000
VERSION     DAVHIZ010000128.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.130"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..>1074
                     /locus_tag="VVO18_002044"
     CDS             <1..>1074
                     /locus_tag="VVO18_002044"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000750032.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="serine protease"
                     /protein_id="HEU5587113.1"
                     /translation="YGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNII
                     LRKGYALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRVLSETTIYADSRNVED
                     GRSTQAVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYT
                     GEDKSNVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKG
                     GFNWELRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKV
                     TDMDGNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNI
                     NDKRNNGFDGEIQEQHIYVNGKEY"
BASE COUNT          423 a          133 c          212 g          306 t
ORIGIN      
        1 tatgggaatg tcatagaatt aggggaagga gatctttcaa aaaacaaacc agacaattta
       61 actaaaatgg aatctggaaa aatctattct gattcagaaa aacaacaata tctgttaaag
      121 gataatatca ttctaagaaa aggctatgca ctaaaagtga ctacctataa tcctggaaaa
      181 acggatatgt tagaaggaaa tggagtctat agcaaggaag atatagcaaa aatacaaaag
      241 gccaatccta atctaagagt cctttcagaa acaacaattt atgctgatag tagaaatgtt
      301 gaagatggaa gaagtaccca agctgtatta atgtcggctt tggacggctt taacattata
      361 aggtatcaag tgtttacatt taaaatgaac gataaagggg aagctatcga taaagacgga
      421 aatcttgtga cagattcttc taaacttgta ttatttggta aggatgataa agaatacact
      481 ggagaggata agtccaatgt agaagctata aaagaagatg gctccatgtt atttattgat
      541 accaaaccag taaacctttc aatggataag aactacttta atccatctaa atctaataaa
      601 atttatgtac gaaatccaga attttattta agaggtaaga tttctgataa gggtggtttt
      661 aactgggaat tgagagttaa tgaatcggtt gtagataatt atttaatcta cggagattta
      721 cacattgata acactagaga ttttaatatt aagctgaatg ttaaagacgg tgacatcatg
      781 gactggggaa tgaaagacta taaagcaaac ggatttccag ataaggtaac agatatggat
      841 ggaaatgttt atcttcaaac tggctatagc gatttgaatg ctaaagcagt tggagtccac
      901 tatcagtttt tatatgataa tgttaaaccc gaagtaaaca ttgatcctaa gggaaatact
      961 agtatcgaat atgctgatgg aaaatctgta gtctttaaca tcaatgataa aagaaataat
     1021 ggattcgatg gtgagattca agaacaacat atttatgtaa atggaaaaga atat
//
LOCUS       DAVHIZ010000129          948 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.131, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000129 DAVHIZ010000000
VERSION     DAVHIZ010000129.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 948)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.131"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..933)
                     /locus_tag="VVO18_002045"
     CDS             complement(<1..933)
                     /locus_tag="VVO18_002045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001850477.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587114.1"
                     /translation="MKKFSLLTIFIVAGQLLLIYAATINALVLNELIAMNLERFLKLS
                     IYQMIVWCGIIFLDWVVKNYQVEVIQEFNLEIRNRVATDISNSTYQEFHSKSSGTYLS
                     WLNNDVQTLNDQAFKQLFLVIKGISGTIFAVVTLNHYHWSLTVATLFSLMIMLLVPKI
                     FASKMREVSLNLTSQNEAFLKSSETILNGFDVLASLNLLYVLPKKIKEAGILLKMVIQ
                     RKTTVETLAGAISFFLNIFFQISLVFLTGYLAIKGIVKIGTIEAIGALTGVIFTALGE
                     LGGQLSSIIGTKPIFLKLYSINPIESNKMNDIEPN"
BASE COUNT          338 a          163 c          127 g          320 t
ORIGIN      
        1 atttggttcg atatcattca ttttatttga ctcaattgga ttaattgaat acaattttaa
       61 aaaaataggc ttcgtaccaa taatagagga taattgacct cctaattcac ctagcgctgt
      121 aaaaataaca cctgttagtg ctcctattgc ttcaatagta ccaattttca ctattccttt
      181 tattgcaaga tagcctgtta aaaaaacgag agatatctga aaaaaaatat tgagaaagaa
      241 gctaatagcg cctgctaacg tttctacagt tgtctttctt tgtataacca tctttaataa
      301 aattcctgct tctttaattt tcttaggcaa tacatataaa agattcaagg acgctaacac
      361 atcaaatcca ttcaatatag tctcactaga ttttaaaaaa gcttcatttt ggctagttaa
      421 atttagacta acttctcgca ttttcgatgc aaagattttt ggtacaagta gcataatcat
      481 taatgaaaac aaggtggcta cagtcaatga ccaatgatag tgattaagag tcacaactgc
      541 aaatatagta ccagaaattc cttttattac taaaaaaagt tgtttaaaag cctgatcatt
      601 taaagtctga acatcattat ttagccacga aagatatgtt cctgatgatt tactatgaaa
      661 ttcttgatag gtagagttag agatgtctgt ggcaactcta tttcgaatct ctagattaaa
      721 ctcttggatc acttcaacct gataattttt cactacccag tcaaggaata ttatcccaca
      781 ccagacaatc atttggtaga ttgacaattt caaaaaccgc tctaaattca tcgcaattaa
      841 ttcattcaac accagagcat taatagttgc tgcataaatt agcaataatt gaccagcaac
      901 aataaatatc gttaataaac taaatttttt tatatttgat tttataat
//
LOCUS       DAVHIZ010000130          897 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.132, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000130 DAVHIZ010000000
VERSION     DAVHIZ010000130.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 897)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.132"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..322)
                     /locus_tag="VVO18_002046"
     CDS             complement(<1..322)
                     /locus_tag="VVO18_002046"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000619809.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587115.1"
                     /translation="MIRKLIIFLLMLPLFVLWLELHVLVNNLLLNLESPLDFVISMSL
                     AFCSLILSKIVLDILYALKDLYKKEALITIFPFIFIGRKKVNVRFSPYFSFHRKSLSP
                     DDLRS"
     gene            complement(836..897)
                     /locus_tag="VVO18_002047"
                     /pseudo
     CDS             complement(836..897)
                     /locus_tag="VVO18_002047"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424479.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
BASE COUNT          334 a          178 c          117 g          268 t
ORIGIN      
        1 tagatcttaa atcatcaggc gacaaacttt tacgatggaa tgaaaaatag ggcgagaacc
       61 tcacatttac tttcttcctg cctataaaaa taaaaggaaa aatcgtaata agagcttctt
      121 tcttgtacaa atctttcaat gcgtatagta tgtctaaaac tatttttgat aaaatcaaac
      181 tacagaaagc aagactcata ctaatcacaa aatcaagggg agattctaga ttcaatagta
      241 agttattcac taggacatgc aactctagcc acaagacaaa aagagggagc attaataaaa
      301 aaatgattag tttacgtatc ataattttac agtgtcctta tcattttctt aattttggat
      361 aaattatcat tgctatgatt aaaatcaaaa aaacgacatt catccaaata atcaactttt
      421 ttatttcttc gctaacaaaa tcataggcta aaaaagttat ggatgatata aataaacata
      481 caaaaaaaat aataacaaaa attttttcca ttttaatacc catatctagt taccacaagg
      541 cgtttaaatt tgggtctctc ctatttacat cattgttggc ccagattgtt gtaatagcat
      601 cgccaattga catccaagct gcaaatccat taatagcaga cagtgcaaat cctgccactc
      661 tatttgcaac tcgtacccca acatatcttg cagctgctcc agcaattgcg cttgtaactc
      721 gccgcaaacc ataattacga atataatttc taactagact gattgctcct ccacctaaaa
      781 caccattaaa agctatatta atggctgttg caacaggcca tctcggaata gaaaatcccc
      841 catcaagata catcatctct tcttgctcaa gaacaacata attatttggt aatacga
//
LOCUS       DAVHIZ010000131          831 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.133, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000131 DAVHIZ010000000
VERSION     DAVHIZ010000131.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 831)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 831)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.133"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(83..822)
                     /locus_tag="VVO18_002048"
                     /pseudo
     CDS             complement(83..822)
                     /locus_tag="VVO18_002048"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000069862.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="PIG-L family deacetylase"
BASE COUNT          288 a          161 c           97 g          285 t
ORIGIN      
        1 tatatttaga tgcaaatagt aacgcgtagg ccagcccaac atgccccaaa ccaattactg
       61 ctatattcat aaaactactt ccttatttct taatccaaaa tataatagaa taaactgccc
      121 cattccttaa atacaactct ttaatattgt ttaaaagttt ttcaactgat ttccagatta
      181 tcaaaatctg agatttatag cacaatattg atgatattct atcaatataa tgtttttcat
      241 cgagttcctc ttgatacatt tttaattctt tagtttttcc catataacta accatactac
      301 tatcacttac atatgggaaa tcctcataat atattacttt ataacgcata aattcaagcg
      361 cccttccaat actattcaca aaaacatgat caacatggtc accaagtgaa agcggacaat
      421 atacgacaca tttgtcgtct aaatgcatta acagctcttt tatgatatca ttctttaatg
      481 tgtcctcatt ttttaattca ctatagatat gacggtatag aaaattgcca tttctatctt
      541 tcctatagag acattcatag tacgataagt gtctaaaatc acattgtaga cgttcacaag
      601 ctaacctatc ttctttcttc ctttcttcaa tcggatatta cacaacttat gaaattgctt
      661 agcagagggc tgtagctgtt gactcaaagg gtaaccagaa aatatagtaa taacaagtac
      721 aatttctcct tctgaagtta attttgaaat ataatcacca caggaaaaaa ttgcgtcatc
      781 taaatgtgga gataaaaaga tatacttagt attgttactc ataaccattc c
//
LOCUS       DAVHIZ010000132          820 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.134, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000132 DAVHIZ010000000
VERSION     DAVHIZ010000132.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 820)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.134"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..359)
                     /locus_tag="VVO18_002049"
     CDS             complement(<1..359)
                     /locus_tag="VVO18_002049"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001837003.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587116.1"
                     /translation="MKNKRYFFDTILIILLLISTIFCVSPVFIKLDILGTPSHAILTF
                     VLAIPLFYILSQCLHTLLLLVSSIFCKLRPIYFYFIFVIIIGARKYYRILFHQLMGFS
                     PGVAVFYKESQTTKNLF"
BASE COUNT          294 a          149 c          111 g          266 t
ORIGIN      
        1 ttaaacagat tcttagttgt ttgactctcc ttataaaaca ctgctactcc tggactaaat
       61 cccattagtt ggtgaaagag aattcgatag tatttcctag ctcctataat gatcacaaat
      121 ataaaataaa aataaattgg tcttaattta caaaagattg aggaaactag taatagcaaa
      181 gtatgtaagc attgagacaa aatatagaat aacggtatcg ccaatacaaa ggttaagatg
      241 gcatgagagg gggttcctaa gatgtccaat tttataaata ctgggctgac acaaaatatc
      301 gtgcttataa gcagtaaaat tattaaaatt gtgtcaaaaa aataacgttt atttttcatt
      361 tagtctactt tccattgtta aataatacta ctgctaacac caagccaact tagcacattg
      421 catcacctaa tcctgcgcta cttgtccata atcctttaat gtttctacta aaattattcc
      481 aatctccccc atcaagatag cttatttatc ctagacaatg ccctactgca acagtataaa
      541 taagattcat cagccatctt ttctggcaat catatgagta gcctaatgat atttctagtt
      601 actcaaaaat atctagctat actagagtta tttctaatcc ctaggacact tgttaatcca
      661 aatgtaacaa attttcaccc cttaatagga ctctttctgg aaaaaatata aggtctatct
      721 ttataaaaaa atctatcata ttgggatggc acgcatctgg aatttaaaca agctataaat
      781 tcatttataa ctactatttg tttagaggca acagcatctt
//
LOCUS       DAVHIZ010000133          804 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.135, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000133 DAVHIZ010000000
VERSION     DAVHIZ010000133.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 804)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.135"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..628)
                     /locus_tag="VVO18_002050"
     CDS             complement(<1..628)
                     /locus_tag="VVO18_002050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001834264.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587117.1"
                     /translation="MVLYPFTYDGSWRFQPINLLYFPEMVRDVIPINLVQEYCQGQPY
                     GLLKKMLKRIRLSREISLLLATIIVYFFTHRILPLSVFTFIFSYILLFAQSYLGGNTV
                     WIGNRRLIIDDEFEKILLSKSYIKEISSARYSEYLTCEYKNLTPIILLAIFENLLDSY
                     LIQNQSKVDLDIFYKVLPLLYKEKYTMGFNYFVSLNYLLYKVGFLGIIY"
     gene            complement(577..804)
                     /locus_tag="VVO18_002051"
                     /pseudo
     CDS             complement(577..804)
                     /locus_tag="VVO18_002051"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001850940.1"
                     /note="frameshifted; incomplete; missing N-terminus;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
BASE COUNT          313 a          127 c          107 g          257 t
ORIGIN      
        1 cgtaaatgat tcccaaaaat ccaaccttat atagtaaata atttaaactt acaaagtaat
       61 tgaatcccat agtatatttt tctttataaa gcaaaggtaa aactttataa aaaatatcta
      121 agtcaacctt actctgattc tgaatcaagt aggagtcaag caaattttca aaaatagcta
      181 acaatatgat tggtgtaagg tttttgtatt cacatgtcaa gtattccgag tatcgtgcag
      241 atgatatttc ttttatataa ctttttgaaa gcaagatttt ttcaaattca tcatctatta
      301 ttaatcttct atttccaatc caaacggtat taccacccaa ataagattgt gcaaatagca
      361 atatgtaaga aaatatgaac gtaaatactg aaagaggtag aattctatgc gtaaaaaaat
      421 agacgataat agtagccagg agtaaagata tctctcgtga caatcgaatt cttttcagca
      481 tcttttttaa cagtccgtaa ggttgtcctt ggcaatattc ttgaactaaa ttaatcggaa
      541 tgacatctct caccatttct ggaaagtaga gtaagtttat aggttgaaat ctccagctcc
      601 catcataagt aaatggatat agaaccaaat acttaaaaga tttttttctt ataaacttaa
      661 ttatcacaat atgaatgact gttccaatga agtatattaa atataaaagt aaaaccgcca
      721 tcaatatact tacaaaaatc cccttggaat caatcaatgg aaaataaaat attgcaacta
      781 gaagcgaata aaatcccgct aata
//
LOCUS       DAVHIZ010000134          803 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.136, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000134 DAVHIZ010000000
VERSION     DAVHIZ010000134.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 803)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 803)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.136"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(12..599)
                     /locus_tag="VVO18_002052"
     CDS             complement(12..599)
                     /locus_tag="VVO18_002052"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001821496.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587118.1"
                     /translation="MNSFITIFKEAIGNSSNFDEESTKLGITKKKIPISVLCEHQNYL
                     KFETIQNNLENFKLFARTTHTIGNFTVFPNWMNCGRGLRLGDYWDITLISLQEFLNIL
                     SPEAWENFIKMYHLQPYVNSDYSVELFWDNHNNNAIRPTKEENFQIFLKKVNERIEER
                     GKFIIKQICDQLDQKDFNFYKEIENMDKIKFSNEF"
BASE COUNT          254 a          124 c          111 g          314 t
ORIGIN      
        1 aatcctcctt tttaaaattc attagaaaat tttattttat ccatattttc aatttcttta
       61 tagaaattga aatctttttg atctaattga tcacaaattt gtttaatgat aaatttacca
      121 cgttcttcaa ttcgttcatt gacttttttg aggaaaattt gaaaattctc ttcttttgtg
      181 ggcctgatgg cattattatt atgattatcc caaaataact ctacactata atcagaatta
      241 acatatggtt gaaggtggta catttttatg aagttttccc atgcttcagg agatagaatg
      301 tttaaaaatt cttgaagtga tattaaagtg atatcccagt aatcacctag tctaagacct
      361 ctaccacaat tcatccaatt aggaaatact gtaaaatttc cgattgtatg agttgttctt
      421 gcaaataatt taaagttctc taaattattt tgaatagttt caaattttaa ataattctga
      481 tgttcacaaa gaacagaaat tgggattttc ttctttgtta tgcctaattt tgttgactct
      541 tcatcaaaat ttgaactatt tccaatggcc tccttaaaga tggtaataaa ggagttcatt
      601 gtttctcctc taatggtact atcttgtgat tcttgccatc ccaaacattt atatagaaag
      661 aatgcagctt tatcacaatc tataccctca ttttcaggga gctgtctgta ttttaaaaaa
      721 gcagtaatac tatcattggg tagtggagaa agtgagtggt ttttaaaatc ccattcccat
      781 ggtttgatat tattttcatc aca
//
LOCUS       DAVHIZ010000135          752 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.137, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000135 DAVHIZ010000000
VERSION     DAVHIZ010000135.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 752)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 752)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.137"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(89..334)
                     /locus_tag="VVO18_002053"
     CDS             complement(89..334)
                     /locus_tag="VVO18_002053"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000513491.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587119.1"
                     /translation="MDIYGRKTIAMKHFFAGIGEIHFLLFLLYLSMSTSPIIGLVIGY
                     TKINLINSIIIALGMILALILVLSRVYRKYFYRDDDD"
     gene            complement(315..677)
                     /locus_tag="VVO18_002054"
     CDS             complement(315..677)
                     /locus_tag="VVO18_002054"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000424421.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="argininosuccinate lyase"
                     /protein_id="HEU5587120.1"
                     /translation="MELVLPNNYVVLEQEEMIYLDGGGVGCNWWNKRDNIAAAAVSGG
                     MSVYQTYAIKKLIANRGMMSRVVRSAITRYIGGVSMATITNALNIAATVAEVFSLGGA
                     IAYGLDIVDGKFDGYLWA"
BASE COUNT          260 a          162 c           90 g          240 t
ORIGIN      
        1 taaagcaaag ctttaaaccc ttccccagac gttagctttt attcaaccca ctacagttga
       61 caaggagccc aaattattga taaaaacttt agtcatcatc gtctctataa aaatattttc
      121 tatacactct tgataatacc aaaattaatg ccaatatcat accaagagct ataataatag
      181 aatttattag atttatttta gtatatccaa tcactagtcc aataattgga ctggtagaca
      241 tgcttagata taataaaaat aacaaaaaat gaatttcacc aattcctgca aaaaaatgtt
      301 tcatagctat agttttacgc ccataaatat ccatcaaatt taccgtctac gatatctaaa
      361 ccatatgcaa tggctcctcc taatgagaag acttcagcaa cagtagccgc aatattaaga
      421 gcattagtaa tagttgccat actaactcca ccaatatatc ttgttatagc acttctaacg
      481 actcggctca tcataccacg attagcaatt aactttttaa tggcatatgt ctggtatact
      541 gacatccctc cagaaactgc agctgcagca atattatcac gtttgttcca ccagttacaa
      601 ccaacaccac ccccatcaag atatatcatc tcttcttgct caagaacaac ataattattt
      661 ggtaatacga gttccattta ttttctcctt ttttattaag catagttagg atagtttcct
      721 aacaagtgat cgttgacttt gtttatagca ct
//
LOCUS       DAVHIZ010000136          681 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.138, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000136 DAVHIZ010000000
VERSION     DAVHIZ010000136.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 681)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 681)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.138"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            296..>681
                     /locus_tag="VVO18_002055"
     CDS             296..>681
                     /locus_tag="VVO18_002055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001811282.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587121.1"
                     /translation="MTSSTEFGNFVSNLSFQHGIAGLLFPLNKLYPPELDSKILSIIK
                     KAVTIRTTHTYEYQYSLLFGDAGYLWLLLHLFSISKNQYYLQLANVTSKKLIENYDTL
                     EEIDFALGKSDVLLSLIKYYQFTNDNT"
BASE COUNT          259 a          110 c           91 g          221 t
ORIGIN      
        1 attatttcat tttactataa tattcgacaa gttatcctaa aagtgttatt atgttgttgt
       61 gttatagatt gattgaatct aactaaagga tcctattcaa ttactagaac tatcacatac
      121 tcaaggtcag atcacagatg agcaactatt ttggttacaa tgtctactaa atttaagtca
      181 aacaaataat ttagtcaaaa ttaaaaaaat agaggaacat aaatatgatt acaaaacaga
      241 atgtaatagt gttctacgat ttttactaga taaaactgta aattctgaag gaaggatcac
      301 ttcttcaaca gaatttggaa atttcgtaag taatttatca ttccaacacg gaatagctgg
      361 actactgttt cctctaaata aattgtaccc cccagaactg gattctaaaa tactctctat
      421 catcaagaag gcagtgacaa ttagaacgac acatacatat gaatatcaat actcactgct
      481 atttggtgat gcaggctatc tatggttact cctacattta ttttctatca gtaaaaatca
      541 atactatcta caattagcaa acgtcacctc taagaaatta atagagaatt atgatactct
      601 agaggaaata gactttgcat tgggaaaatc tgatgtccta ttatcattaa taaaatacta
      661 tcaatttacc aatgacaata c
//
LOCUS       DAVHIZ010000137          654 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.139, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000137 DAVHIZ010000000
VERSION     DAVHIZ010000137.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 654)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 654)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..654
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.139"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..408
                     /locus_tag="VVO18_002056"
     CDS             <1..408
                     /locus_tag="VVO18_002056"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001854454.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="HEU5587122.1"
                     /translation="PTDYDEKIGSFNTYEIEQTVSKILRVKPNGKIILKSTVPIGFSN
                     KLKRLFDTKNIIFVPEFLREGCSIYDNLYPSRIVVGDETVEGRKIAELFLSISTHSTA
                     NIKNVMLVSPTEAEAIKLFSNTFLALRVAFLMN"
     gene            372..>654
                     /locus_tag="VVO18_002057"
     CDS             372..>654
                     /locus_tag="VVO18_002057"
                     /inference="COORDINATES: protein motif:HMM:NF013175.1"
                     /note="catalyzes the formation of UDP-glucuronate from
                     UDP-glucose; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="UDP-glucose 6-dehydrogenase"
                     /protein_id="HEU5587123.1"
                     /translation="MLSSPCCFFNELDSFAERRSLNAEVVIKGVCLDPRIGNFYNNPS
                     FGFGGYCLPKDTKQLKKEFIEINAPVIEAIDISNTNRKQFIVKQILERKP"
BASE COUNT          237 a           86 c          118 g          213 t
ORIGIN      
        1 ccgacagatt atgatgagaa aattggtagt tttaatacat atgaaatcga acaaacggta
       61 tcgaagattc tgagggtaaa acctaatgga aagattattt taaagtcaac agttccgatc
      121 ggcttttcaa acaaattaaa aaggctgttt gatacaaaaa atatcatttt tgtccctgaa
      181 tttttgagag aaggttgttc tatatatgat aatttatatc caagtcgcat agttgttgga
      241 gatgagacag ttgaaggaag aaaaattgca gagttgttcc tttcgattag tactcatagt
      301 actgccaata ttaaaaatgt tatgttagtt tctcctactg aagcagaagc aattaagctt
      361 ttttctaaca cattcttagc tctccgtgtt gcttttttaa tgaactagat tcttttgctg
      421 agaggagaag cttaaatgct gaagttgtaa taaaaggtgt ttgtttagat ccaagaattg
      481 gaaattttta taataatcct tcttttggat ttggaggata ttgtcttccc aaagatacta
      541 aacaattaaa aaaagaattt atagaaataa atgccccagt gatagaagcg attgatattt
      601 caaacacaaa tagaaaacag ttcatagtta aacaaatatt ggaacgaaag ccaa
//
LOCUS       DAVHIZ010000138          608 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.140, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000138 DAVHIZ010000000
VERSION     DAVHIZ010000138.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 608)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.140"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            <1..240
                     /locus_tag="VVO18_002058"
     CDS             <1..240
                     /locus_tag="VVO18_002058"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000588926.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU5587124.1"
                     /translation="YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEK
                     QEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH"
     gene            334..405
                     /locus_tag="VVO18_002059"
     tRNA            334..405
                     /locus_tag="VVO18_002059"
                     /product="tRNA-Glu"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.7"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /anticodon=(pos:367..369,aa:Glu,seq:ttc)
BASE COUNT          232 a           90 c          140 g          146 t
ORIGIN      
        1 tacgataaag aaccctatga agaagtgggt gagatcagtc atcgtataag tgaggggggt
       61 ctctggctag atgattatta tctctttcat gaaacactaa gagattatag aaacaaacaa
      121 agtaaagaga aacaagaaga actagaacgc gtcttaagca atgaacgatt tcgagggcgt
      181 caaagagtat taagagactt acgcattgtg tttaaggagt ttactatccg tacccattag
      241 taagtcatgc aaaaaaaatg aaaaaaatta gaaaaagtag ttgacaaagt ttgaaaaggc
      301 tgtataatag taagagttga aaataacaac tcaggtccgt tggtcaaggg gttaagacac
      361 cgccttttca cggcggtaac acgggttcga atcccgtacg gactatggta tgttgcgtca
      421 ggagcacttg atgaaaaaaa gtttaaaaaa acttaaaaat cttcaaaaaa gtgttgacaa
      481 gtgaaagtgg ctgtgatata ctaatatagt tgtcgcttga gagaagcaag tgacaaagac
      541 ctttgaaaac tgaacaagac gaaccaatgt gcagggcgct acaacataag ttgtagtact
      601 gaacaatg
//
LOCUS       DAVHIZ010000139          604 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.141, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000139 DAVHIZ010000000
VERSION     DAVHIZ010000139.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 604)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 604)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.141"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            3..548
                     /locus_tag="VVO18_002060"
     CDS             3..548
                     /locus_tag="VVO18_002060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001834445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587125.1"
                     /translation="MLLPLIPFSIIIALVQKLYRIENQQLFLLKSKVLTILESKKDCE
                     FNLQDYHEIWKLQSKSELPCVALSYISLIKPYLSESVREQIDLLEVKRFKKINHPISL
                     YGMLDVIKLNLYLRHYNEKNKYESMLNKILEVRPDFVLIEQNIDDSLNSSQPLSLSLA
                     ISEIQLLLEVYMGIKHVSIRR"
BASE COUNT          216 a           80 c           97 g          211 t
ORIGIN      
        1 cgttgctttt gcctcttatt ccattttcta ttatcatagc attagtacaa aaactttata
       61 gaattgagaa tcaacaatta tttctgttaa aatcaaaggt actaacaata ctggaatcta
      121 agaaggattg tgagtttaat cttcaggatt atcatgaaat ttggaaattg caatcaaaat
      181 ctgagttgcc atgcgtggct ttatcttata tcagtttgat caagccatat ctttcagaga
      241 gcgtgcgtga acaaattgat ttattagaag ttaagcgatt taaaaaaata aatcatccaa
      301 tatcacttta tggtatgttg gatgttataa aattaaatct atatttacgg cattataatg
      361 aaaaaaataa atatgaatca atgttaaata aaattttaga ggtaagacca gactttgttt
      421 taatcgagca gaatattgat gatagtttaa atagctcgca accattatct ttatctttag
      481 ccatttcaga aatccaactt ttgcttgaag tgtatatggg gatcaaacat gtttcaatta
      541 ggagataaaa ccagaataat atttgccatt ataggggcaa gttgcatatt agtcagtatg
      601 tatc
//
LOCUS       DAVHIZ010000140          596 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.142, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000140 DAVHIZ010000000
VERSION     DAVHIZ010000140.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 596)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 596)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.142"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            186..>596
                     /locus_tag="VVO18_002061"
     CDS             186..>596
                     /locus_tag="VVO18_002061"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008902124.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PcfB family protein"
                     /protein_id="HEU5587126.1"
                     /translation="MINEEISKEAGQAAQTIISYTIKATKESINLEKEIRKKMNETLE
                     KANGNLKSLMGDEMKIKDLYKKGQLENISIDQIDLKDLKKELNKLGVSFSVMKNKESK
                     NYEIFFQAKDIKVMEYAFKQVIAKENKKEKESILK"
BASE COUNT          313 a           80 c           91 g          112 t
ORIGIN      
        1 aggtggaaag gtagtgtaag ctatttttaa aagtataaaa ggtacaaaga cctaagaaat
       61 atataaaaac atcaaaataa agtattccac caccaagaac aataaaataa aaacaagcaa
      121 agggaagtat agaaaaatta aaacctatac ttcccttttt taattcaaac aaaggagaga
      181 aaagcatgat aaacgaagaa ataagcaagg aagcaggtca agcagcacaa accataatat
      241 catacacaat aaaggcaaca aaagaatcaa tcaatttaga aaaagaaata agaaaaaaga
      301 tgaatgaaac tttagaaaaa gcaaatggaa acttaaaaag tcttatgggc gatgaaatga
      361 aaataaaaga cctctacaag aaaggacaac tagaaaatat aagcatagat caaatcgacc
      421 tcaaagactt aaaaaaagaa ctaaacaaac ttggagtaag tttctcagta atgaaaaaca
      481 aagaaagcaa aaactatgaa atattcttcc aagccaaaga cataaaagta atggaatatg
      541 cctttaagca agtcatagcc aaggaaaata aaaaagaaaa agaaagtatc ctaaaa
//
LOCUS       DAVHIZ010000141          591 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.143, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000141 DAVHIZ010000000
VERSION     DAVHIZ010000141.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 591)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.143"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            56..>591
                     /locus_tag="VVO18_002062"
     CDS             56..>591
                     /locus_tag="VVO18_002062"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001068699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="HEU5587127.1"
                     /translation="MNPLKECYEKNGILIAAHRGTNGGNILQNTSKAYLNSIRHNADM
                     FEVDVIRSKDGEFFAFHDGQEPLVFGEKIDIRTLSSEEIQRKECFNSLNEPILQKIEK
                     ISDVLKDFEGQSLINIDRSWFYWDTFLDKLKIYPSLNQVLLKSPVKKELLEMLRDSGL
                     NVMYMPIIKTIEELDFVLS"
BASE COUNT          230 a           75 c          103 g          183 t
ORIGIN      
        1 acgttccaag aaatcggata caatgtaatt aacaataaag ataggagaaa ataatttgaa
       61 tccattaaaa gaatgctatg aaaaaaacgg tatactaatt gcagcacacc gtggtacaaa
      121 cggaggaaat atattacaaa acacatcaaa agcctatttg aattccatac gccataacgc
      181 agatatgttt gaagttgatg taattcgttc aaaggatgga gaattttttg catttcacga
      241 tgggcaagaa cctttagtat ttggtgaaaa aattgatatt agaactttga gttctgaaga
      301 gatccaaaga aaggaatgtt ttaattcact gaatgaaccc atattacaaa agattgaaaa
      361 aatttctgat gtattaaaag attttgaggg acagtcttta ataaatatag atagaagttg
      421 gttttactgg gataccttcc tagataagtt aaaaatatat ccatctttga atcaagttct
      481 tttaaaatca cctgtaaaaa aagaattatt ggaaatgctt agagactctg gtttgaatgt
      541 tatgtatatg ccaattatca aaacaattga agagttagat tttgttctct c
//
LOCUS       DAVHIZ010000142          462 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.144, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000142 DAVHIZ010000000
VERSION     DAVHIZ010000142.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 462)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 462)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.144"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            complement(<1..>462)
                     /locus_tag="VVO18_002063"
     CDS             complement(<1..>462)
                     /locus_tag="VVO18_002063"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001808790.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=2
                     /transl_table=11
                     /product="transposase"
                     /protein_id="HEU5587128.1"
                     /translation="CRYSDSDILVQFLFQLLTGYGTDYACKELSADAYFPKLLEGGQL
                     ASQPTLSRFLSRTDEETVHSLRCLNLELVEFFLQFHQLNQLIVDIDSTHFTTYGKQEG
                     VAYNAHYRAHGYHPLYAFEGKTGYCFNAQLRPGNRYCSEEADSFITPVLER"
BASE COUNT          150 a           92 c          106 g          114 t
ORIGIN      
        1 aaccgttcta aaacaggtgt gataaagctg tctgcctctt cagaacaata acgattacca
       61 ggacgaagct gggcattgaa acaataacct gtcttcccct cgaaagcata aagaggatga
      121 tagccatgag cacgatagtg ggcgttataa gcaacacctt cttgcttgcc ataagttgtg
      181 aaatgggtag aatcgatatc tacaatgagt tggtttagct ggtgaaactg taaaaagaat
      241 tcgaccaatt caaggttgag gcatcgcaaa ctatggactg tttcctcgtc agttctggaa
      301 agaaaacggg ataaggttgg ctgtgaagca agctgccctc cttccaacaa ttttggaaag
      361 taggcatcag ctgacaattc tttacaagca tagtccgttc cataacctgt taacagttga
      421 aagaggaact ggacaaggat atctgaatcc gaataacgac ag
//
LOCUS       DAVHIZ010000143          441 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.145, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000143 DAVHIZ010000000
VERSION     DAVHIZ010000143.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 441)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 441)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.145"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            20..439
                     /locus_tag="VVO18_002064"
     CDS             20..439
                     /locus_tag="VVO18_002064"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842057.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587129.1"
                     /translation="MDELIQNKERKIKELSQNNFLSTLEQTLLSNHYDELNGVSFNIV
                     LKASIGSVIEESYRNTKHYSIDEWQKLRQEMEKDIKNVNPSLETSVTPRLYLDENVLN
                     GLDEFRYHLMKEDGATRLPRLSYIIKLVVYSYWKTQQ"
BASE COUNT          180 a           67 c           65 g          129 t
ORIGIN      
        1 atatgaagcc aaagtatgga tagatgaact tattcaaaat aaagaacgta aaatcaaaga
       61 actaagtcag aataattttc taagtacatt agaacaaaca cttctatcaa atcattacga
      121 tgaattaaat ggtgtctctt tcaatatagt tttaaaagct tctatcggaa gtgtcattga
      181 agaatcatat agaaatacaa aacattactc cattgatgaa tggcaaaaac tacgtcaaga
      241 aatggaaaaa gacatcaaaa atgtcaatcc tagtctagaa acatccgtaa ctcctagact
      301 ctatttagat gaaaatgttc taaatggtct tgatgaattt cgatatcatt taatgaaaga
      361 agatggtgct actagattac caaggcttag ttacatcatt aaacttgttg tatattccta
      421 ttggaagaca caacaataac c
//
LOCUS       DAVHIZ010000144          437 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.denovo.146, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000144 DAVHIZ010000000
VERSION     DAVHIZ010000144.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 437)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 437)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.denovo.146"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
BASE COUNT          152 a           84 c           65 g          136 t
ORIGIN      
        1 cccaaactct tcacacaaga gttctaactt acccattcta tggaatcttg cattatccat
       61 aatatagtag attgaaacta gaatagtaca cctctacttc taaaacattg ttagaattcg
      121 atttgactat cctcggtttg tcctattctt atttcacctt actataaaaa taaggtaaac
      181 ttttcaaaaa aacacgaaaa aagcacccat agggcaaacc tttgagtgct ttgaaacatt
      241 gatataatcg tattgattaa cgttttgagg caactgacct tgtcaggttg cagccacatt
      301 tgtaagcgac taaagtcgca acaactgtgt caattgcacc aatttagtaa gaaagtataa
      361 aaaaagaaca ccccgaaagg tgctctgtat aagtatagta attctttcga attaacgttt
      421 actaaattgt gatgctt
//
LOCUS       DAVHIZ010000145        26186 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.guided.028, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000145 DAVHIZ010000000
VERSION     DAVHIZ010000145.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 26186)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26186)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..26186
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.guided.028"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            604..765
                     /locus_tag="VVO18_002065"
     CDS             604..765
                     /locus_tag="VVO18_002065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761276.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587130.1"
                     /translation="MDNDWNGLADLIANLIAKYAGALDLDNLPDPTPAKNQEMKNSFD
                     MAKTQIETD"
     gene            857..2536
                     /locus_tag="VVO18_002066"
                     /pseudo
     CDS             857..2536
                     /locus_tag="VVO18_002066"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031864.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
     gene            2804..3370
                     /locus_tag="VVO18_002067"
     CDS             2804..3370
                     /locus_tag="VVO18_002067"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016397777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587131.1"
                     /translation="MVILELYQNDYSKDLVAFDSIEDGKAFVAQIPGYTLETEDGFEV
                     EYFNPKNIPDYMEIIFNGNIVPLSRFMFDPGENVNIIWKEISNLSLKNDRVIEGYSKI
                     DAYVVNNHEVKAYVETRETNYRKAKDFLESRGYEIDRSFFGSEDGEAILYRKKGIEVW
                     HFLCHLDPMFVEIEDVEGYVKEEVGEIQ"
     gene            3692..3880
                     /locus_tag="VVO18_002068"
     CDS             3692..3880
                     /locus_tag="VVO18_002068"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000179767.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family transcriptional regulator"
                     /protein_id="HEU5587132.1"
                     /translation="MATDKNRIMISLDDKNLEKLENLVEDARDRRGMRLTKSQVIELL
                     LNTVDYFDDIMGAIYSKK"
     gene            3942..4700
                     /locus_tag="VVO18_002069"
     CDS             3942..4700
                     /locus_tag="VVO18_002069"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262024.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="HEU5587133.1"
                     /translation="MVVYIRQSKLPSEVSINKYNAQVGAYLQGEEVILYQSFSEIKEL
                     ISEDIVVDYIMETRALLKMMGLNVPVYDYPIELKEFYGRKIYAGILGEIVNIPDNWGK
                     FIKPKAGSKVFTGRVVNGTHDLIGIGLPFDYPIWISEVVEFIAEWRCFVLDGRVLDVR
                     PYTGDYHAQFDASVIDEAISCWKDAPIAYGLDIGVTRDGRTLVVEVNDGYALGNYGLS
                     PLKSINFHRARWKEMVKSYFEKNEIFKIQQDVIF"
     gene            4758..5612
                     /locus_tag="VVO18_002070"
     CDS             4758..5612
                     /locus_tag="VVO18_002070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900021.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="HEU5587134.1"
                     /translation="MLGAIIGDIVGSVYEWNNIKTKDFPLFRKDCFFTDDTVMTCAVA
                     EAIMNGGQKDDFIDAMKKYGRMYPNADYGARFNAWLNSDNREPYNSFGNGSAMCISPC
                     AWIMDCGFYAKTGMWPSSRGLTSLSAEVTHNHPEGVKGAMATADAIFLCRFYFGGYCR
                     EYEQSINDNPTECKRRIKDYIEKEYDYNLSQTLDEIRPNYRFNETCQETVPQAIIAFL
                     ESRDFEDAIRNAISLGGDSDTLAAITCNIAEAAYGIPDWIKDKAYSYLDEPLKDVVRR
                     WENRIKAY"
     gene            5724..6608
                     /locus_tag="VVO18_002071"
     CDS             5724..6608
                     /locus_tag="VVO18_002071"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000710121.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="diacylglycerol kinase family lipid kinase"
                     /protein_id="HEU5587135.1"
                     /translation="MKKAMVIINPTSGGEKALDYKEKLENKAKEYFEYVETKITEKAL
                     DATHFAEEASREQYDAVVVFGGDGTVNEVISGIDERDYIPKLGIIPGGTGNLITKLLE
                     INQDIDGAIDELDFDLTNKIDIGKANDNYFGYIFSIGSLPEAIHNVEIEDKTKFGILT
                     YAVNTMKSVMTDQVFNIKVETENGNYVGEASHVLVLLTNYFADKKIFEENKDGYANIL
                     ILKDASIFSKLSVIPDLLKGDVIANDNIEYIKARNIKISSDSELESDVDGDKSDNLPV
                     EIKVLAQRVEVFSKPKED"
     gene            6771..8510
                     /locus_tag="VVO18_002072"
                     /pseudo
     CDS             6771..8510
                     /locus_tag="VVO18_002072"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015511339.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-glycosidase"
     gene            8785..9087
                     /locus_tag="VVO18_002073"
     CDS             8785..9087
                     /locus_tag="VVO18_002073"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001863727.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587136.1"
                     /translation="MGAARDFLELINHKGLPLFNPLVGDSHVNNRQEYDNTGSGNLQP
                     EKWNETAKQLYNVIMWLIILWNAKPDTPLFNFKDEVIKYKTYEPFESSIKLVSINE"
     gene            9143..9571
                     /locus_tag="VVO18_002074"
     CDS             9143..9571
                     /locus_tag="VVO18_002074"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013903432.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="HEU5587137.1"
                     /translation="MDGITKDFIKTAKLMKQLWPQLTDKEAIDEVKKYTNGKNTAIFT
                     EVEGDTIVGLALCSLRFDYVEGCKYSPVGFLEGIIVDEEYRLKDIAKNLCTKCEEWAK
                     NKGCKEFASDCTLTNTDSIRFHLNIGFQEANRIIHFKKKL"
     gene            9629..10238
                     /locus_tag="VVO18_002075"
                     /pseudo
     CDS             9629..10238
                     /locus_tag="VVO18_002075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000662948.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="Type 1 glutamine amidotransferase-like
                     domain-containing protein"
     gene            10520..10767
                     /locus_tag="VVO18_002076"
                     /pseudo
     CDS             10520..10767
                     /locus_tag="VVO18_002076"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335280.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside phosphotransferase"
     gene            10872..11174
                     /locus_tag="VVO18_002077"
                     /pseudo
     CDS             10872..11174
                     /locus_tag="VVO18_002077"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105201.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo
                     /codon_start=1
                     /transl_table=11
                     /product="transposase family protein"
     gene            11330..12559
                     /locus_tag="VVO18_002078"
     CDS             11330..12559
                     /locus_tag="VVO18_002078"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012512582.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="FtsW/RodA/SpoVE family cell cycle protein"
                     /protein_id="HEU5587138.1"
                     /translation="MKISKRHLLNYSILIPYLLLSILGLIVVYSTTSAILIEEGKSAL
                     QLVRNQGIFWIVSLILIALIYKLRLDFLRNERLIILVILIEMLLLFLARFIGISVNGA
                     YGWISVAGVTIQPAEYLKIIIIWYLAHRFSKQQEEIATYDFQVLTQNQWLPRAFNDWR
                     FVLLVLIGSLGIFPDLGNATILVLVSLIMYTVSGIAYRWFSTILALVSATSVFVLTTI
                     SLIGVETFSKIPVFGYVAKRFSAFFNPFADRADAGHQLANSYFAMVNGGWFGLGLGNS
                     IEKRGYLPEAHTDFVFSIVIEEFGFVGASLILALLFFMILRIILVGIRAENPFNAMVA
                     LGVGGMMLVQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAVAFVLNIDASEKR
                     AKLYRELENQPMNLLLK"
     gene            12579..15275
                     /gene="ppc"
                     /locus_tag="VVO18_002079"
     CDS             12579..15275
                     /gene="ppc"
                     /locus_tag="VVO18_002079"
                     /EC_number="4.1.1.31"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000058210.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoenolpyruvate carboxylase"
                     /protein_id="HEU5587139.1"
                     /translation="MSLQKLENYSNKSVVQEEVLILTELLEDITKNMLAPETFEKIIQ
                     LKELSTQEDYQGLNRLVTSLSNDEMVYISRYFSILPLLINISEDVDLAYEINHQNNID
                     QDYLGKLSTTIKLVAEKENAVEILEHLNVVPVLTAHPTQVQRKSMLDLTNHIHSLLRK
                     YRDVKLGLINKDKWYNDLRRYIEIIMQTDMIREKKLKVTNEITNAMEYYNSSFLKAVP
                     HLTTEYKRLAQAHGLNLKQAKPITMGMWIGGDRDGNPFVTAKTLKQSALTQCEVIMNY
                     YDKKIYQLYREFSLSTSIVNVSKQVREMARQSKDNSIYREKELYRRALFDIQSKIQAT
                     KTYLIEDEEVGTRYETANDFYKDLIAIRDSLLENKGESLISGDFVELLQAVEIFGFYL
                     ASIDMRQDSSVYEACVAELLKSAGIHSRYSELSEEEKCDLLLKELEEDPRILSATHAE
                     KSELLAKELAIFKTARVLKDKLGDDVIRQTIISHATSLSDMLELAILLKEVGLVDTER
                     ARVQIVPLFETIEDLDHSEETMRKYLSLSLAKKWIDSRNNYQEIMLGYSDSNKDGGYL
                     SSCWTLYKAQQQLTAIGDEFGVKVTFFHGRGGTVGRGGGPTYEAITSQPLKSIKDRIR
                     LTEQGEVIGNKYGNKDAAYYNLEMLVSAAINRMITHKKSDTNTPNRYEAIMDQVVDRS
                     YDVYRDLVFGNEHFYDYFFESSPIKAISSFNIGSRPAARKTITEIGGLRAIPWVFSWS
                     QSRVMFPGWYGVGSSFKEFINKNPENIAILRDMYQNWPFFQSLLSNVDMVLSKSNMNI
                     AFEYAKLCEDEQVKAIYETILNEWQVTKNVILAIEGHDELLADNPYLKASLDYRMPYF
                     NILNYIQLELIKRQRRGELSSDQERLIHITINGIATGLRNSG"
     misc_binding    15358..15575
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:12.0:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.1"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
     gene            15688..16692
                     /locus_tag="VVO18_002080"
     CDS             15688..16692
                     /locus_tag="VVO18_002080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398145.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="HEU5587140.1"
                     /translation="MKNKRLIGIIAALAVLVAGSLIYSSMNKSEAQNNKDEKKITKIG
                     VLQFVSHPSLDLIYKGIQDGLAEEGYKDDQVKIDFMNSEGDQSKVATMSKQLVANGND
                     LVVGIATPAAQGLASATKDLPVIMAAITDPIGANLVKDLKKPGGNVTGVSDHNPAQQQ
                     VELIKALTPNVKTIGALYSSSEDNSKTQVEEFKAYAEKAGLTVETFAVPSTNEIASTV
                     TVMTSKVDAIWVPIDNTIASGFPTVVSSNQSSKKPIYPSATAMVEVGGLASVVIDQHD
                     LGVATGKMIVQVLKGAKPADTPVNVFSTGKSVINKKIAQELGITIPESVLKEAGQVIE
                     "
     gene            16762..17628
                     /locus_tag="VVO18_002081"
     CDS             16762..17628
                     /locus_tag="VVO18_002081"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399556.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="HEU5587141.1"
                     /translation="MIVSIISQGFVWAILGLGIFMTFRILNFPDMTTEGSFPLGGAVA
                     VTLITKGVNPFLATLVAVGAGCLAGMAAGLLYTKGKIPTLLSGILVMTSCHSIMLLIM
                     GRANLGLLGTKQIQDVLPFDSDLNQLLTGLIFVSIVIALMLFFLDTKLGQAYIATGDN
                     PDMARSFGIHTGHMELMGLVLSNGVIALAGALIAQQEGYADVSRGIGVIVVGLASLII
                     GEVIFKSLSLAERLVTIVVGSIAYQFLVWAVIALGFNTSYLRLYSALILAVCLMIPTF
                     KQTILKGAKLSK"
     gene            17625..18383
                     /locus_tag="VVO18_002082"
     CDS             17625..18383
                     /locus_tag="VVO18_002082"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000125420.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="HEU5587142.1"
                     /translation="MTAIVELKNATKIVKNGFDEEKIILNDVSLEIFEQDFITILGGN
                     GAGKSTLFNTIAGTISLTSGTIRILGEDVTKFSPEKRAKYLSRVFQDPKMGTAPRMTV
                     AENLLIAKFRGEKRGLFPRRLASYKDKFQATIEKVGNGLEKHLNTPIEFLSGGQRQAL
                     SLLMATLKRPELLLLDEHTAALDPKTSVALMELTDEFVKKDQLTALMITHHMEDALKY
                     GNRLIVMKEGRVIQDLKQEEKAKMKISDYYQLFE"
     gene            18473..20233
                     /gene="dnaG"
                     /locus_tag="VVO18_002083"
     CDS             18473..20233
                     /gene="dnaG"
                     /locus_tag="VVO18_002083"
                     /EC_number="2.7.7.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000227865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA primase"
                     /protein_id="HEU5587143.1"
                     /translation="MVDKQVIEEIKNNANIVEVIGDVISLQKAGRNYLGLCPFHGEKT
                     PSFNVVEDKQFYHCFGCGRSGDVFKFIEEYQGVTFMEAVQILGQRVGIEVEKPLYSEQ
                     KPASPYQALYDMHEDAAKFYHAILMTTTMGEEARNYLYQRGLTDEVLKHFWIGLAPPE
                     RNYLYQRLSDQYREEDLLDSGLFYLSDANQFVDTFHNRIMFPLTNDQGKVIAFSGRIW
                     QKTDSQTYKYKNSRSTAIFNKSYELYHMDRAKKSSGKTSEIYLMEGFMDVIAAYRAGI
                     ENAVASMGTALSREHVEHLKRLTKKLVLVYDGDKAGQAAILKALDEIGDMPVQIVSMP
                     DNLDPDEYLQKNGPEDLAYLLTKTRISPIEFYIHQYKPENSENLQAQIEFIEKIAPLI
                     VQEKSIAAQNSYIHILADSLASFDYTQIEQIVNESRQVQRQNRMERISRPTPITMPVT
                     KQLSAIMRAEAHLLYRMMESPLVLNDYRLREDFAFATPEFQVLYDLLGQYGNLPPEVL
                     AEQTEEVERAWYQVLAQDLPAEISPQELSEVEMTRNKALLNQDNMRIKKKVQEASHVG
                     DTDTALEELERLISQKRRME"
     gene            20236..21345
                     /gene="rpoD"
                     /locus_tag="VVO18_002084"
     CDS             20236..21345
                     /gene="rpoD"
                     /locus_tag="VVO18_002084"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000201905.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RNA polymerase sigma factor RpoD"
                     /protein_id="HEU5587144.1"
                     /translation="MATKQKEVTTFDVQVAEFIRNHKQKGTATDDEINASLVIPFTLD
                     ADGIEDLLQRIQDAGISITDNEGNPSARVLSNEEEPELSDEDLIGSTSAKVNDPVRMY
                     LKEIGVVPLLTNEEEKELALAVEAGDIEAKQRLAEANLRLVVSIAKRYVGRGMQFLDL
                     IQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINK
                     LVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLG
                     DFIEDEVIENPVDYTTRIVLREQLDEILDTLTDREENVLRLRFGLDDGKMRTLEDVGK
                     VFNVTRERIRQIEAKALRKLRQPSRSKPLRDFIED"
     gene            21359..21688
                     /locus_tag="VVO18_002085"
     CDS             21359..21688
                     /locus_tag="VVO18_002085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000331934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="HEU5587145.1"
                     /translation="MAYTEEQIENIKTRILTALEEVIDPELGIDIVNLGLIYEIRFDG
                     DTGQTEIDMTLTTMGCPLADLLTDQIYDAMIEVPEVTDTEVKLVWYPAWTVEKMSRYA
                     RIALGIK"
     gene            21803..22846
                     /gene="cpoA"
                     /locus_tag="VVO18_002086"
     CDS             21803..22846
                     /gene="cpoA"
                     /locus_tag="VVO18_002086"
                     /EC_number="2.4.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016398149.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-galactosylglucosyldiacylglycerol synthase"
                     /protein_id="HEU5587146.1"
                     /translation="MEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVT
                     ENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVK
                     RYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLR
                     TDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYK
                     KIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRD
                     LDLYKVILEGNYRATAGREEMKEAILEYQANPAALKDLKEKAKNISREYSEEHLLQIW
                     LDFYEKQAALGRK"
     gene            22862..24187
                     /locus_tag="VVO18_002087"
     CDS             22862..24187
                     /locus_tag="VVO18_002087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="HEU5587147.1"
                     /translation="MRIGLFTDTYFPQVSGVATSIRTLKTELEKQGHAVFIFTTTDKD
                     VNRYEDWQIIRIPSVPFFAFKDRRFAYRGFSKALEIAKQYQLDIIHTQTEFSLGLLGI
                     WIARELKIPVIHTYHTQYEDYVHYIAKGMLIRPSMVKYLVRGFLHDVDGVICPSEIVR
                     DLLSDYKVKVEKRVIPTGIELAKFERPEIKQENLKELRSKLGIQDGEKTLLSLSRISY
                     EKNIQAVLVAFADVLKEEDKVKLVVAGDGPYLNDLKEQAQNLEIQDSVIFTGMIAPSE
                     TALYYKAADFFISASTSETQGLTYLESLASGTPVIAHGNPYLNNLISDKMFGTLYYGE
                     HDLAGAILEALIATPDMNEHTLSEKLYEISAENFGKRVHEFYLDAIISNNFQKDLAKD
                     DTVSQRIFKTVLYLQQQVVAVPVKGSRRMLKASKTQLISMRDYWKDHEE"
     gene            24218..24394
                     /locus_tag="VVO18_002088"
     CDS             24218..24394
                     /locus_tag="VVO18_002088"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016399487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PspC domain-containing protein"
                     /protein_id="HEU5587148.1"
                     /translation="MRSGRDKKIAGVCAGVAHYLDMDPTIVQVIWGVLTCCYGAGIVA
                     YIILWIIAPVATDY"
     gene            24453..24587
                     /locus_tag="VVO18_002089"
     CDS             24453..24587
                     /locus_tag="VVO18_002089"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000863859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4044 domain-containing protein"
                     /protein_id="HEU5587149.1"
                     /translation="MAFGDNGNRKKTMFEKITLFIVIIMLVASLLGIFATAIGALSNL
                     "
     gene            24651..25961
                     /gene="obgE"
                     /locus_tag="VVO18_002090"
     CDS             24651..25961
                     /gene="obgE"
                     /locus_tag="VVO18_002090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000061643.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GTPase ObgE"
                     /protein_id="HEU5587150.1"
                     /translation="MSMFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGG
                     NVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAET
                     GKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKIL
                     ADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGL
                     IEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLME
                     RPQIIVANKMDMPESQENLEEFKKKLSENYDEFEELPAIFPISGLTKQGLATLLDATA
                     ELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNF
                     DRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD"
     gene            25971..26129
                     /locus_tag="VVO18_002091"
     CDS             25971..26129
                     /locus_tag="VVO18_002091"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841691.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587151.1"
                     /translation="MGDKPISFRDADGNFVSAADVWNEKKLEELFNRLNPNRALRLAR
                     TKKENPSQ"
BASE COUNT         8523 a         4173 c         5722 g         7768 t
ORIGIN      
        1 atatgacact ttaaaggcga ttagaaaatt aaagaaatgc tagaagactt ttagatgaca
       61 gttaccaaga ggatctaatt ttcactgcta cttatgcagt gggaattgga cctttttata
      121 taagcaaatt ctatttcaaa attggttacc aagaaagact tcttttcact gttaagtata
      181 agagggtaat ttatagaatt ttgttacatc aagataaata ttttctgatg gtcaaatttt
      241 aaaaagatta ataactctcg ataaattttg aaccttaaca attgaataga ccaagacaag
      301 gcgttaatta tttttggagc gtaataacct atccgtcaag atctttcggc tgaataattc
      361 ggcaaaaaaa gttctgctaa gcaaaaagaa agtgagcgat aagtaagagt ttgaatatag
      421 ggagggatac cctatccgct atgaagaaaa tgaggataat gatacttcta aggttgaagc
      481 cggctcatcc ggaatagagg cggaggtgag attcctatgt tgctaatcca aagcacttgt
      541 caatgtcaaa aaacttaatt aaacaaataa ttattagata taaaacttta gaggaggtat
      601 atattggaca atgactggaa tggattggct gatttaatag caaatctgat tgcaaaatat
      661 gctggtgctt tagatttaga taatctaccc gatccaacgc cagcaaaaaa tcaagagatg
      721 aaaaatagtt ttgacatggc aaaaacacaa attgagacgg actaataaaa gtgttataat
      781 atacttgaaa tgatagtcca aacttaaatt aaaaaaatta tatatgatat agaaaaatta
      841 tattgaggtt aatactatgt caaaagaaaa aataaaagta tacctctata cacgagtatc
      901 tacgtcaata cagatagagg ggtattcgtt agaggcacaa aaatcacgaa tgaaagcttt
      961 tgctatttac aacgattatg aaattgttgg agagtatgaa gatgccggga agtctggcaa
     1021 gtctattgaa ggtagaatac agttcaatcg aatgatggaa gatataaaat ctggaaaaga
     1081 tggagtatct tttgttcttg tgtttaagtt atcaagattt gcaagaaatg ccgctgatgt
     1141 tctttctaca cttcagataa tgcaggatta tggagttaat cttatctgcg ttgaagatgg
     1201 cattgattca tctaaagatg ctgggaaact aatgatttct gttttataag ctgtggctga
     1261 aatagaaaga gaaaacatcc gtattcaaac aatggaaggt cgcattcaaa aagcaaggga
     1321 aggaaaatgg aatggtggct ttgctccgta tggatataaa cttgaagacg gcaagctgtt
     1381 tataaatgag gaagaggcag ttgcaataag aacgattttc gaccagtatg taaatactac
     1441 gataggagct aatgggatat ctaaatactt agagaatcat ggaattagaa aaatcccaag
     1501 acagaatggt aagaatcctt tgtttgatgc aggtcttata agaaagatat taaagaatcc
     1561 tgtatataat gggaaaatag catttggaag aagaacttta gaaaaagttc atggtacaag
     1621 aaatgaatat aagcaggttg aacaagatga atatctaata tctgaaggga tacatgaagc
     1681 tatagtttcc gatgaagttt ggcaagctgc tcaggttaag ctaaaatctc aagcaaagaa
     1741 atatgagcat gtgaataaag gaaaagatac acgcacacac ttgctttctg gaattgtaaa
     1801 atgcccgata tgtggagtgg gaatgtttgg gaacaagtgt atcaagaaaa agaaagatgg
     1861 cacaaagtat aaagattttt attactatgg ttgtaaacat aggcagatga taagaggtca
     1921 taagtgtaca ttcagtaagc aaattagaga agaattgtta gatgatgctg ttgcagaggt
     1981 gattgtcaag atagtaagta atccgaaatt tgcttctatg atgcaagaaa aaatcaacat
     2041 gaaggtggat acctctgaaa tagaaaaaga aatagataat taccaaaagg aattgagaaa
     2101 gagtcattct acaaagttta agctaattga ggaaatagat aatttagatg ttgaagataa
     2161 gcattataag agaaggaaac aggatttaga tgatagacta tatcgtatgt atgacaaaat
     2221 agatgaatta gaatcatcac taattgatgc gaaagcaaag aaacagacta ttgaagctga
     2281 aaagcttaca ggagataaca tatataaggt tctgatctat tttgataagc tctataaagt
     2341 catgaatgat gtagagcgta ggcagttaat ttcagctttg atttctgaaa ttcaagttta
     2401 tgaagaaaaa caatctaacg gacaatggct aaaatccatt acttttaagc taccaattat
     2461 agaagaaaat ctcaacatag gtttggacaa tgatgaacaa gttgaatgtg taagtttatt
     2521 agagaaacgt agttaatcct caaaaggttc cccgaacctt ttgagtccca ctgacgcatc
     2581 acgctgaggc ggtatcactg cttgtacgag ttgaagcatc agcaaagtaa aagtagatgt
     2641 tcagccaatg cgacgaggtg agaccgaagg tcgataaggt gtgttctggg tataggactc
     2701 gtaaagtaag taggaaatat gatgagatga tacagagagc ctgaattggt caggtgacgt
     2761 gcttatttac attagcctga taatgaaaat ggagagatta tcgatggtta tattggaatt
     2821 gtaccaaaat gattattcta aagatttagt agcatttgat tccatagaag atgggaaagc
     2881 ctttgtagct caaatcccgg gatacactct ggaaacagaa gatggttttg aagtggagta
     2941 ttttaatcct aaaaacatac cggattatat ggaaattatt tttaacggaa atattgttcc
     3001 tttatctaga tttatgttcg atcctgggga aaatgtaaac attatttgga aagagatttc
     3061 aaatttatcc ctcaaaaatg atagagtgat cgaaggatat tcaaaaattg atgcatatgt
     3121 cgttaacaac catgaagtta aagcctatgt cgaaacaaga gaaacgaact atcgtaaagc
     3181 aaaagacttc ttagaaagcc gcggatatga aatcgacaga agctttttcg gaagtgaaga
     3241 cggtgaagcg attctttaca gaaaaaaagg gatcgaagtt tggcatttct tgtgtcactt
     3301 agacccaatg tttgtagaga ttgaagatgt agaaggatat gttaaagaag aagttggaga
     3361 gattcaatag tcaaccaaag ttccttgtga gtatatacct ttgctagtaa aagagtcaaa
     3421 acgttataac gaaggggggg aagaaaaccc ttgagtgtaa gtctttttct tgtttagagg
     3481 gaaagtatta gagtagccgc tcataattta tactagattt gataactgat ttgagacaga
     3541 ttttatttct ataaatattg tgaaaatttt ttaataccaa agatttaaag ttactgtgtt
     3601 aaaaatcctc tccactttta aactaatgta ttataaaagc cagttgacac aagtgttaca
     3661 cctgtgatag aattaacttg aggtgatgaa aatggcaacc gataaaaata gaataatgat
     3721 tagcttggat gataaaaatc tagagaaact tgaaaattta gtagaagatg ctagagatag
     3781 aaggggaatg cgactaacaa agtcccaggt tattgaatta ctcctaaata ccgttgatta
     3841 tttcgatgat attatggggg ctatttactc aaaaaaataa gagcaaaatt gctattattt
     3901 tttacaaatt ggtgtaacac tagtgatata ggagtgatga aatggttgtt tatattagac
     3961 aaagtaaatt accaagtgag gtttcaatta ataaatacaa tgctcaagta ggtgcctact
     4021 tacaaggaga agaagttatt ttatatcaat ctttttctga aataaaagag ttaataagtg
     4081 aagatatagt tgtagattat ataatggaga ctagagcatt actaaaaatg atgggcttaa
     4141 acgttccggt ttatgactat cctattgagc ttaaagagtt ttatggtcga aagatttatg
     4201 ctggtatttt aggagagatt gtgaatatac ctgataattg gggaaaattt attaagccta
     4261 aagctggttc aaaagtcttt actggaagag ttgttaatgg aacccatgat ttaataggta
     4321 ttggtctacc tttcgactat cctatatgga ttagtgaggt tgtagaattc atagctgaat
     4381 ggcgttgttt tgtgttagat ggtcgcgtat tagatgttcg accctataca ggtgattatc
     4441 atgcacaatt tgatgcaagt gtaattgatg aagcgatatc atgttggaaa gatgcgccaa
     4501 tagcttatgg actagatatc ggtgttactc gcgatggcag aacacttgtt gttgaagtaa
     4561 atgatggtta tgcattggga aattatggcc tatctccttt aaaatcaatc aattttcata
     4621 gagctaggtg gaaagaaatg gtaaaatcct attttgaaaa aaatgaaatt tttaaaatcc
     4681 aacaggatgt tattttctaa aataaatatg gtagataacc aatataaaaa gcatcaaaat
     4741 gaacaaggag gaatctgatg cttggagcaa ttattggaga tattgtcggt tctgtttacg
     4801 aatggaacaa tatcaaaaca aaggactttc ctttatttcg gaaggactgc ttttttacag
     4861 atgacacggt tatgacctgt gctgttgcag aagcaattat gaatggtgga caaaaagacg
     4921 atttcattga cgcgatgaag aaatatggca gaatgtatcc gaatgctgat tacggtgctc
     4981 ggtttaatgc atggctaaac agcgataacc gtgagcctta taatagcttt gggaatggat
     5041 cagctatgtg tatttctcca tgtgcttgga tcatggactg tggtttttat gcgaaaactg
     5101 gtatgtggcc atcatctaga ggacttacga gtctttctgc agaggtaact cataatcatc
     5161 cagaaggtgt caaaggcgct atggctacag ctgatgctat ctttctatgt cgtttttact
     5221 ttggtggtta ttgtagagag tacgagcaat caattaacga caatcctaca gagtgtaaaa
     5281 gacgaattaa ggattatata gaaaaagaat acgattacaa tctatctcaa actttagatg
     5341 aaatccgtcc taactatcgt tttaacgaaa catgtcagga aactgtccct caagccatta
     5401 tcgcctttct tgaaagtaga gacttcgaag atgcgataag aaatgccatc tcacttggtg
     5461 gcgacagtga tactctcgca gcaatcactt gtaacatagc agaggcagct tacggtattc
     5521 ctgattggat caaggataag gcctattctt acttggatga acccttaaag gatgtagtta
     5581 ggcgatggga aaatagaata aaagcgtatt aatctccagt acgtcagatt tctcttttct
     5641 gtattttcat tgtataatag gattacattt acttgcatac gacgaaatgt aaacatttct
     5701 gtttaaaatt aaggataaaa tcaatgaaaa aagcaatggt aattatcaac cctacttctg
     5761 gtggcgagaa ggctttggat tacaaagaaa agctggagaa taaagcaaaa gaatactttg
     5821 aatatgttga aaccaaaatt accgaaaaag cgctggatgc aacacatttt gctgaagaag
     5881 cttctcgtga gcagtatgat gcagtggttg tgtttggtgg agatggaact gtcaatgaag
     5941 tcatttcagg tattgatgag agagactaca ttcctaagtt agggattatc ccaggcggta
     6001 cgggtaacct cattacaaaa cttttggaaa tcaatcaaga catcgatggc gcaattgacg
     6061 aactggattt tgatttaacc aataagattg atatcggtaa agcaaatgac aactattttg
     6121 gttatatctt tagtatcggt tctctgcctg aggcgattca caatgttgaa atagaggaca
     6181 aaacaaaatt cggtatttta acctatgctg taaataccat gaagtctgtc atgacagatc
     6241 aggtctttaa cattaaggtt gagacagaaa atggaaatta tgttggtgaa gctagccatg
     6301 ttttggtcct tttgacaaat tacttcgctg ataagaaaat ctttgaagaa aacaaggacg
     6361 gctatgccaa cattttgatt ctgaaagatg cctctatatt ctccaaatta tccgtcattc
     6421 ctgatttatt aaaaggggat gttatcgcaa atgataatat cgagtatatc aaagcgcgta
     6481 atattaaaat ctcttcagat agtgaattgg agtcagatgt tgacggagat aaatcagata
     6541 acctacctgt agaaatcaaa gtcctagctc agcgagtaga agtattttca aaaccgaaag
     6601 aggattagta tatagagaaa gcctttttta aggctttttg tatactttaa aagatagttc
     6661 ctttaacaac ggacattcct tgcaaatagt ttacaaaaat agtatactgg attcattgag
     6721 tttgaaaacg tttgcgtaaa atttgaatga atactttagg agacaaattg atggaattga
     6781 gtgctattta ccataggcct gagtcggagt atgcctatct ttataaggat aagaaactcc
     6841 atattcgaat tcgaactaag aaaggggaca ttgaaagcat caacttgcac tatggggacc
     6901 cttttatctt tatggaggag ttttatcagg atacaaaaga aatggtcaag ataacttctg
     6961 gtaccttatt tgaccattgg caggttgaag tgtcagttga ctttgcacgt atccagtatc
     7021 tctttgagct cagagataca gaaggtcaaa atattttgta tggcgataaa gggtgtgtgg
     7081 aaaattctct agaaaatctt catgcaattg ggaatggatt taagttgcct tatcttcatg
     7141 agattgatgc ctgcaaggtt cctgactggg tttcaaatac ggtatggtat cagatatttc
     7201 ctgaaagatt tgccaatggc aatgctctat taaacccaga agggacttta gactgggatt
     7261 catctgtcac acctaagagc gatgatttct ttggtggtga tttacagggg attattgatc
     7321 atatggatta cttgcaagac ttgggtatta ctggactata tctttgtccc atctttgaat
     7381 ctacaagcaa tcacaagtac aatacgacag attactttga aattgaccgt cattttggag
     7441 acaaggagac ctttcgggaa ctggtggatc aagcgcatca tcgtggcatg aaagtcatgc
     7501 tggatgcggt atttaatcat attggttcgc aatctcttca atggaaaaat gtcgtcaaaa
     7561 atggtgaaca gtctgcttat aaggattggt tccatattca acaattccca gtgacaactg
     7621 aaaagctagt taataagaga gacttaccct atcatgtttt tggtttcgag gactatatgc
     7681 ctaagctaaa tacagccaat ccagaggtca agaattatct tttaaaggtt gcgacttatt
     7741 ggattgaaga gtttaatatc gatgcttggc gtttggatgt ggctagtgag attgaccatc
     7801 agttctggaa ggattttcgt aaggcagttt tagctaaaaa tcctgatctt tatatcctag
     7861 gagaagtctg gcatacatct cagccttggc taaatggaga tgagttccat gccgtcatga
     7921 attatccttt atctgatagt atcaaggact atttcttacg aggaattaag aagacagacc
     7981 agttcatcga tgaaatcaat tgagagtcta tgtattacaa gcagcagatt tcagaggtca
     8041 tgtttaatct cttggattca catgatacag agcgaatcct gtggacggcc aatgaagatg
     8101 ttcaactggt taaatcagcc ttagcctttc tcttttaaca aaaaggaaca ccgtgcattt
     8161 attacggaac cgagctagcc ttgactggag gaccagatcc agattgtcgt cgttgtatgc
     8221 cttgggaacg tgtatcaagt gacaatgata tgctgaactt tatgaagagg ctgattaaga
     8281 ttcggaaata cgcgtcagta atcatttcgc atggcaagta tagccttcaa gaaatcaaat
     8341 ctgatctagt agctctggaa tggaaatacg aaggatggat cctcaaagca atattcaacc
     8401 aatcaacaga agattatctt ttagagaaag aagcagtagc actagcaagc aattgccaag
     8461 aattggagaa tcagcttgtc atctctccag atggatttgt gattttctaa aaactagttg
     8521 atgaagatta tggtacattt catatcttat atagtataat aaggctagtt actaaacttg
     8581 taaaggagaa cttaaatgaa ttgtagagga catgaaacaa gacaaagaat tgttagagat
     8641 tttgaagttt agcctaaagc acatattaag ctgttagcaa atcaacaaaa acatagtgat
     8701 gcaggagcaa ctattgaaga tgaatattat gtatttatcg ctgagagtaa aattgatggc
     8761 aagaaggaag ttattcagtg ttgcatgggt gcggcaaggg attttttaga actaattaat
     8821 cacaaagggc tacctctttt taatccgctt gtaggtgatt ctcatgtaaa taatagacaa
     8881 gaatatgaca atacagggag tggaaattta caacctgaaa agtggaatga aactgcaaag
     8941 cagctttata atgttataat gtggttgatt attttatgga atgctaagcc ggatacacct
     9001 ttatttaatt ttaaagacga agtaattaag tataaaacat atgagccttt tgaaagcagt
     9061 ataaaattgg tatcaatcaa tgagtaacaa agtatcagca tgattcgaaa catttacttg
     9121 taatttgcgg aggaacatca atatggatgg aataacaaaa gattttataa aaacggctaa
     9181 actaatgaaa caattatggc cccaattgac cgataaagaa gctattgatg aagtaaaaaa
     9241 atatacgaat ggcaaaaata ctgcaatctt tactgaagtt gaaggtgaca caattgtagg
     9301 tctagcacta tgttcactca gatttgatta tgttgaaggt tgtaaatata gtcctgttgg
     9361 attcttagaa gggattattg ttgacgagga atatcgttta aaggatattg ctaaaaatct
     9421 ctgtacaaaa tgtgaggaat gggcgaaaaa taaaggatgt aaggaatttg caagtgactg
     9481 tactttaacg aatacggatt ctataagatt tcatctcaat attggatttc aggaggcaaa
     9541 tagaattatt cattttaaga aaaaattata atttagaaac gtgaataaac ttgtttaaac
     9601 tttatgtatc tttagaaagt gtgttaactt gaaagaacaa atttttttga tgggtgggaa
     9661 tcccccaatg aagaaatata gtattgttga taaaattgta ttatcaacca agattaaaag
     9721 aattatcatt tttacagttt ttcgagaaaa ttgggaaccg tacatgaaaa agtacacgga
     9781 agtttttcaa agtcaatttc ctaatctaaa cattgattac ttgctcctgg acactgagca
     9841 gattgatctt gatagctatc tagatgctga cataattatc atcggtggtg gaaatacgga
     9901 aaaatatatt gctaacttat gttaatcagg agttcaaaag ttatatcgat catatgctta
     9961 ataaagaggc aaaaattata ggattttctg caggagccct actattagga gaaaaagtct
    10021 atgtctcacc taatgataat tcagatcatc agataaagat aaaaaatgga ttaggactct
    10081 ttagtcagtt tttaattagt gtccattatg attcctggaa tgataaagca aataaggata
    10141 gagctgaaga actcgttaat gttcccataa ttccactaaa tgatcattct tgtcttgtat
    10201 tggataaact tggaaacatc atagagaaaa ttgactaact ttcataatgt aaaaatggat
    10261 ctaggaaata aaagtgtaga cgaactggat aggttactag tgaaaactgc aaaaagtgtt
    10321 gtaaagtgaa tcggagtgtg cttgatggat tttagtagta agatagccat aaataaaggc
    10381 tggtcagatg ataaaaaata ttgtgtgaca gatcaaaatc agtaaaaata tttcttgcgt
    10441 gtttctgata agtcgaagtt agattataaa aaaatttgaa tttgatatga tggagaaagt
    10501 agcttctctt ggagttccga tgtgtaaacc aattagcatt gaactctgcg atgacgaagt
    10561 acattcttta cacgaatgga tagacggaag agatgcaata gatagcattt tagcttattc
    10621 agaaaaccaa caatacacat atggtgtaga agcaggaaag atacttagaa agattcatac
    10681 aattcctgct acagaagttt gtgaagattg ggaaattttt ttaatctaaa aattgatgat
    10741 aaaatctcca acgaaatgat atggtaagtc cgaaacgctc agtgtgtaag cttgttgcta
    10801 aaagcgtaaa aaccttggaa cgaaaggaat aatagacttc ctgcgaaaca aaaatacaat
    10861 acaataaaac tatggatgat gaagcaagta aacaattaag cgatagccgt ttcaagatcc
    10921 ttgtaggtgt tcagcgcacg acttttgaag agatgttagc tgtgttaaaa acagcttatc
    10981 aacgtaaacg cgcaaaaggt ggacgaaaaa gcaaattaag cctagacgat ctccttatgg
    11041 taactattca atacatgcga gaatagagca cttatgaaca aattgcggct gattttggca
    11101 ttcacgaaag caacttaatc cgtcggagtc aatgggttga agcaactctt attcaaaatg
    11161 gttttacgat ttcaaattct gccttaattc tgtaaaaaca gtaaaattcg aaggattgta
    11221 aggtaagagt ttttttcttt ctgaaaaaat ggtataatag caatcaaaac tagaaaataa
    11281 aacggaattt ggaacagatt tgtctgtatc ctagtagagt ggtgatacta tgaagattag
    11341 taagaggcac ttattaaatt attccatctt gattccctac ttgcttttat ctattttggg
    11401 cttgattgtg gtctattcga ccaccagtgc tattttaatt gaagaaggca agagcgcctt
    11461 gcagttggtt cgaaaccaag gaatcttttg gattgttagt ttgatactga ttgccttaat
    11521 ttataaattg agactagatt ttttgagaaa tgagcgacta atcattttag ttatattaat
    11581 agaaatgctt ttattgttct tggctcgttt tattggtatt tcagtaaacg gggcatacgg
    11641 ttggatttcg gttgcaggag taactattca gccagctgag tacttaaaaa tcattattat
    11701 ttggtattta gctcaccgat tctccaaaca gcaagaagaa atagctactt atgattttca
    11761 agttttgact caaaatcaat ggcttccccg tgcttttaat gattggcgat tcgttctcct
    11821 agttctgatt ggaagtttgg gaattttccc tgatttagga aatgcgacta ttttagtctt
    11881 ggtttccttg attatgtata cagttagtgg aatcgcttat cgctggtttt caaccattct
    11941 ggcgctcgta tctgccactt ctgtctttgt cttgaccact atcagcctaa tcggtgttga
    12001 gaccttttca aaaattccag tatttggcta tgtagccaag cgctttagtg ccttttttaa
    12061 tccttttgcc gatcgtgctg atgcaggtca ccagttagct aattcttatt ttgccatggt
    12121 caatggtggt tggtttggtc taggtcttgg aaactcgatt gaaaaacgag gttatttgcc
    12181 agaagctcat acagactttg tcttttctat cgtgattgaa gaatttggct ttgttggtgc
    12241 cagtcttatt ttagctctct tgtttttcat gattttgcgg attatcttgg tcggtatccg
    12301 agcggagaat cctttcaatg ccatggttgc actcggtgtc ggagggatga tgttggttca
    12361 ggtatttgtc aatatcggag ggatttcggg cttgattcca tctacaggag tgactttccc
    12421 tttcttatcc cagggtggaa atagtcttct agtcttatca gtggcagtag cctttgtctt
    12481 aaatattgat gccagtgaaa aacgcgctaa gttgtaccga gaattggaaa atcaaccaat
    12541 gaaccttctg ttgaagtagg ataaagaaag gatagtttat gtctcttcaa aaattagaaa
    12601 attatagtaa taaaagtgtt gtgcaagaag aagtcttgat tctaacagaa ttactggaag
    12661 atattactaa aaatatgctt gccccagaga cctttgaaaa aataatacag ttgaaagaat
    12721 tatcaacgca ggaagattat caaggtctaa accgtctagt gactagctta tcaaatgatg
    12781 aaatggtcta tatttcacgc tatttctcta tcttacctct tttgattaat atttcagagg
    12841 atgtggattt agcttatgaa atcaatcatc aaaataatat tgatcaggac tatttaggta
    12901 aattatctac aacgattaaa ttggtagcag aaaaggaaaa tgccgttgag atcctagaac
    12961 acttgaatgt tgtccctgtt ttgacagccc atccaacaca agtgcaacgc aaaagtatgt
    13021 tggatttaac aaatcatatt catagtcttt tgcgtaaata ccgtgatgtt aagttggggt
    13081 tgatcaataa agataaatgg tacaatgatt tgcgtcgtta catcgaaatt atcatgcaga
    13141 cagacatgat tcgtgagaaa aaattaaaag tgactaacga aatcacgaat gctatggaat
    13201 attataacag ctcctttttg aaagctgtac ctcatttgac gacggagtat aagcgcttag
    13261 cgcaagcgca tggtctgaat ttaaaacagg ctaaaccaat caccatgggt atgtggatag
    13321 gtggtgaccg tgatggaaat ccatttgtta cagcaaagac cttgaagcag tctgcactca
    13381 ctcagtgtga agtcatcatg aactactatg ataaaaagat ttaccaactt tatcgtgaat
    13441 tttctctttc aactagcatt gtcaacgtca gcaagcaagt cagagaaatg gctcgtcaat
    13501 ccaaggataa ctcgatttac cgcgaaaaag agctttaccg tcgtgccttg tttgatattc
    13561 aatcaaaaat tcaggcaact aaaacctatc tgattgagga tgaagaagtt gggactcgtt
    13621 atgaaaccgc caatgatttc tacaaggatt tgattgccat tcgagattct ctactagaaa
    13681 ataagggcga gtccttgatt tcaggtgatt ttgtggaatt attgcaggca gtagagatat
    13741 ttggttttta cttagcatca attgatatgc gacaagactc tagcgtctat gaagcctgtg
    13801 tggcagaact cttgaaatca gcaggaattc attctcgtta tagcgagttg agcgaagaag
    13861 aaaagtgtga ccttctcttg aaagaattag aagaagatcc ccgaattctt tctgcgactc
    13921 acgcagaaaa atcagaatta ttagcaaaag aattagctat ttttaagacg gctcgtgttt
    13981 tgaaagataa gttgggagat gatgtcatcc gtcagaccat catttcacat gcaaccagcc
    14041 tttctgatat gctagaatta gctattctgt taaaagaagt aggactggtg gatacggaaa
    14101 gggcgcgtgt tcagattgtt cccctttttg aaacaattga agacttggat cattcagagg
    14161 aaacaatgag aaaatatctt tctcttagcc ttgccaaaaa atggattgac tcacgaaata
    14221 actaccaaga aatcatgctt ggctactctg acagtaataa agatggcggt tacttgtcat
    14281 catgttggac cctctacaag gctcaacaac aattgactgc tattggagat gaatttggcg
    14341 ttaaggttac cttcttccat ggtcgtggtg gtactgtcgg tcgtggtggt gggccaacct
    14401 atgaagccat tacatctcaa ccgctcaagt ctatcaagga tcgtatccgt ttgacggagc
    14461 agggtgaagt aattgggaat aaatacggta acaaagacgc cgcttactat aaccttgaaa
    14521 tgctagtatc tgcagctatt aaccgtatga ttactcataa gaagagtgat accaataccc
    14581 caaatcgtta tgaagccatt atggatcaag tagtggaccg tagttacgat gtctaccgtg
    14641 atttggtctt tggtaatgag catttctatg attatttctt cgagtcaagt ccaatcaagg
    14701 ctatttcaag ttttaatatt ggttctcgtc cagccgctcg taagactatt actgaaatcg
    14761 gtggtttgcg tgccatccct tgggtattct catggtcaca gagtcgtgtt atgttccctg
    14821 gatggtacgg ggttggttca agcttcaagg aatttatcaa taaaaatcca gagaatattg
    14881 ctatcttacg agatatgtac caaaattggc ctttcttcca atcgcttctt tcaaatgttg
    14941 atatggtttt gtcaaaatca aatatgaata ttgcttttga atatgctaaa ctttgtgaag
    15001 acgagcaagt taaggccatc tatgagacta ttttaaatga atggcaagtt actaagaacg
    15061 ttatcttggc tattgaagga catgacgaac tcttagctga caatccatat ctaaaagcta
    15121 gtctggatta ccgtatgcct tactttaata ttctcaacta tattcagtta gagttgatta
    15181 aacgccaacg tcgtggagaa ttgtccagtg atcaagaacg attgattcat atcaccatca
    15241 acggaattgc gacaggattg cgtaattcag gttgataatt ttcaagagtg aatgctaaaa
    15301 gtgaatatca aaaaaattct aatagactat tgacaagtag tttaaaaatg atataattta
    15361 accattcaga aaagtaatca tacaaacttt ttagagagtc tgtggtagct gaaaacagat
    15421 aagtggcaat gatgaaaatt gggctgaatg ctatttagaa tttgaaatta taaaaattcg
    15481 gtaagcacac cttacagtgc atctcgttat tgcgagactg agcgataggg aaattcccta
    15541 taattgaggt ggtaccgcgc atcgacgtcc tcacacaagt tttttgtgtg aggatttttt
    15601 tgatggaggt tagtatggaa agaaaacaat ggcgtcgctt gtttagataa gtgaaatatg
    15661 ttaaaggaaa taaaaaggag aaacagaatg aaaaataaac gtttaattgg aattattgct
    15721 gcattagcag tcttagtagc aggaagcttg atttattctt caatgaataa atcagaagct
    15781 cagaataata aggatgagaa gaaaataacc aagattggtg tgcttcaatt tgtgagccat
    15841 ccatcccttg atttgattta taaagggatc caagatggac ttgcagaaga aggatataaa
    15901 gatgatcaag ttaaaattga ttttatgaac tcagaaggtg accaaagtaa ggttgcgaca
    15961 atgagtaaac aattggttgc aaatgggaat gaccttgtgg ttggtatcgc aacaccagca
    16021 gcccaagggt tggctagtgc aacaaaagac ctaccggtta tcatggccgc tattacagac
    16081 ccaattggtg ctaacttggt taaagatttg aaaaaaccag gtggcaacgt tacaggggta
    16141 tctgaccaca atccagctca acaacaagtt gaactcatca aggctctgac accgaatgtg
    16201 aaaacaatcg gagctcttta ctcaagtagc gaagacaatt caaaaacaca ggtcgaagaa
    16261 tttaaggctt atgctgaaaa agcaggtctg acagtggaaa catttgcagt tccttcaaca
    16321 aatgaaattg cctcaactgt cactgttatg actagcaagg tagatgctat ttgggttcca
    16381 attgataaca ccattgcatc aggatttcca acggttgtct ctagcaatca aagttctaag
    16441 aaaccaattt atcccagtgc gacagctatg gtagaagtag gtggtttggc atcagttgta
    16501 attgaccaac atgaccttgg tgtggcaaca ggtaaaatga ttgtgcaagt cttgaaaggt
    16561 gcaaaaccag ccgatacccc agtcaatgtc ttttcaactg gtaagtcagt catcaataaa
    16621 aaaatagcac aagaactagg tattactatt cctgagtctg ttctcaaaga agcaggacaa
    16681 gtcatcgaat aaataaggta gggaggagga gactcttccc attttttaaa aagatgaatt
    16741 atagaaagga ttaaataaaa tatgattgtt tccattattt ctcaaggatt tgtctgggct
    16801 attctaggtc tgggaatctt tatgacattt aggattttaa actttccaga tatgacgaca
    16861 gaaggttcct tccctcttgg gggagctgtt gctgtcactt tgataaccaa aggcgtgaac
    16921 ccatttttag cgacacttgt tgctgtagga gcaggttgtt tggctggaat ggcagcaggc
    16981 cttctttata caaaagggaa gatcccaacc ttgctctcag ggattttggt gatgacttct
    17041 tgtcactcaa tcatgctctt gattatggga cgtgcgaatt taggcctgct tggaaccaag
    17101 caaattcagg atgttttgcc ttttgattcg gatttgaatc aactcttgac aggtctcatc
    17161 tttgtgagta ttgttattgc tctcatgctc tttttcttgg acactaaact cggacaagcc
    17221 tatattgcta caggggataa tcctgatatg gctagaagtt tcgggattca tactggacac
    17281 atggagctca tgggcttggt cttatcaaat ggtgtgattg cccttgcagg tgccctcatt
    17341 gctcagcaag aaggttatgc cgatgtgtct cgagggatcg gggttatcgt tgtggggctt
    17401 gcaagtttga ttattggaga agttattttc aagagtttga gcttggcaga gcgtttggtt
    17461 actatcgttg taggttctat cgcttatcaa tttttagtgt gggcagttat cgcacttggc
    17521 tttaatacaa gttaccttcg tttatacagt gccttgattt tagcagtctg cctcatgatt
    17581 ccaacattta agcaaacaat cttgaaagga gccaagttaa gcaaatgaca gcaattgtag
    17641 aattaaaaaa tgcaaccaaa atcgttaaaa atggctttga tgaagaaaag attattttaa
    17701 atgatgtttc cttagaaatt tttgaacagg actttatcac gattttgggt ggaaatggtg
    17761 ctggtaaatc aaccctcttt aacactattg caggaaccat atcactaacc agtggaacta
    17821 tccgtatttt aggtgaggat gttaccaagt tttcaccaga gaagcgcgct aagtatctgt
    17881 ctcgagtctt ccaagatcca aagatgggga cagctcctcg tatgacagtg gcagagaatc
    17941 tcctgattgc caagtttcgt ggtgaaaagc gtggactatt tccgagacgt ctggctagct
    18001 ataaggataa gtttcaggcg accattgaaa aagtgggaaa cggtcttgag aaacacttga
    18061 atacaccgat tgagttctta tctggtggac aaagacaggc tttgagtctc ttgatggcaa
    18121 ccttgaagcg acctgaatta ctcttgttag acgagcatac tgctgccctg gatccaaaga
    18181 ctagtgttgc tttgatggaa ttgacagatg aatttgttaa gaaagatcaa ttgacagccc
    18241 ttatgattac ccatcatatg gaagatgctc tcaaatatgg caatcgcttg attgtcatga
    18301 aagaaggacg ggttatccaa gatttgaaac aagaagaaaa agcaaaaatg aaaatctctg
    18361 attattatca actctttgaa taaagtaggg aaaatgagtg aaatggttta ctttttttct
    18421 gaaataaagt atactatata aagtaaacta tgataacatg gaggtattgt gtatggttga
    18481 caaacaagtc attgaagaaa tcaaaaacaa tgccaacatt gtggaagtca taggagatgt
    18541 gatttcttta caaaaggcag gacggaacta tctagggctc tgtccttttc atggtgaaaa
    18601 aacaccttct ttcaacgttg tagaggacaa gcagttttac cactgttttg gttgtggtcg
    18661 ctcaggtgat gtctttaaat tcatcgagga gtaccaaggg gttaccttta tggaggctgt
    18721 ccaaatctta ggtcagcgtg tcgggattga ggttgaaaaa ccgctttata gtgaacagaa
    18781 gccagcctcg ccttaccaag ctctttatga tatgcacgaa gatgcggcta aattttacca
    18841 tgctattctc atgacaacga ctatgggcga agaggccaga aattaccttt atcagcgggg
    18901 tttgacagat gaagtgctta aacatttttg gattggttta gcacctccag aacgaaacta
    18961 tctctatcaa cgtttgtctg atcagtatcg tgaagaggat ttactggatt caggcctgtt
    19021 ttatctctcg gatgccaatc aatttgtaga cacctttcac aatcgcatta tgtttcccct
    19081 gacaaatgac caaggaaagg tcattgcctt ctcaggtcgt atctggcaaa aaacggattc
    19141 acaaacttat aagtataaaa acagccgatc gactgcaatt tttaacaaaa gttacgaatt
    19201 atatcatatg gatagggcaa aaaaatcttc tggaaaaact agtgagattt acctgatgga
    19261 aggattcatg gatgttattg cagcctatcg ggctggaatc gaaaatgctg tggcgtcgat
    19321 gggaacggcc ttgagtcgag agcatgttga gcatctgaaa aggttaacca agaaattggt
    19381 tcttgtttac gatggagata aggctgggca agccgcgata ttgaaagcat tggatgaaat
    19441 tggtgatatg cctgtgcaaa tcgttagcat gcctgataac ttggatcctg atgagtatct
    19501 acaaaaaaat ggtccagaag acttggccta tctattaaca aaaactcgta ttagtccgat
    19561 tgagttctac attcatcagt acaaacctga aaacagtgaa aatctgcagg ctcagattga
    19621 gtttattgaa aaaatagctc ccttgattgt tcaagaaaag tccatcgctg ctcaaaacag
    19681 ctatattcat attttagctg acagtctggc gtcctttgat tatacccaga ttgagcagat
    19741 tgttaatgag agtcgtcagg tgcaaaggca gaatcgcatg gaaagaattt ccagaccgac
    19801 gccaatcacc atgcctgtca ccaagcagtt atcggctatt atgagggcag aagcccatct
    19861 actctatcgg atgatggaat cccctcttgt tttgaacgat taccgtttgc gagaagactt
    19921 tgcatttgct acacctgaat ttcaggtctt atatgacttg cttggccagt atggaaatct
    19981 tcctccagaa gttttagcag agcagacaga ggaagttgaa agagcttggt accaagtttt
    20041 agctcaggat ttgcctgctg agatatcgcc gcaggaactt agtgaagtag agatgactcg
    20101 aaacaaggct ctcttgaatc aggacaatat gagaatcaaa aagaaggtgc aggaagctag
    20161 ccatgtagga gatacagata cagctctaga agaattggaa cgtttaattt cccaaaagag
    20221 aagaatggag taataatggc aacaaaacaa aaagaagtaa caacatttga cgtacaggta
    20281 gcagaattta tccgtaatca taagcaaaaa gggacagcaa cagatgatga aatcaatgca
    20341 agtctggtta ttccttttac cttggacgct gatgggattg aagatctctt gcaacggatt
    20401 caggatgcag gcatttctat cacagataac gaaggaaatc caagtgcgcg tgttcttagc
    20461 aatgaagaag aaccagaact cagcgatgag gacttgattg ggtcaacttc tgctaaggtc
    20521 aatgaccctg tccgtatgta cttgaaagaa ataggggtcg ttcctctctt gaccaatgaa
    20581 gaggagaaag agttggcact ggctgttgaa gctggcgata tcgaagccaa acaacgtctt
    20641 gcggaagcca atcttcgttt ggttgtttcc attgccaaac gctatgtcgg tcgtggcatg
    20701 cagttccttg acttgattca agaaggaaat atgggcttga tgaaggcggt tgacaagttt
    20761 gactattcta aagggttcaa gttttcaact tatgcaactt ggtggattcg tcaggctatc
    20821 actcgtgcta ttgcggacca agctcgtacc atccgtatcc cagttcacat ggttgaaact
    20881 atcaataaat tggttcgtga acagcggaat ctccttcaag aattggggca agatccgaca
    20941 ccagaacaga ttgctgaacg aatggatatg acacctgata aggttcgtga aatcttgaag
    21001 attgcccaag aaccagtatc tcttgaaact cctatcggtg aagaggacga tagccacctt
    21061 ggagacttta tcgaagatga agtgattgaa aatccagtgg attatacgac tcgtatcgtc
    21121 ttgcgtgagc aattggatga aatcttagat actcttacag accgtgaaga aaatgttctg
    21181 cgtctacgtt ttggactaga tgatggaaaa atgcgcacac ttgaagatgt ggggaaagtc
    21241 tttaacgtaa ctcgtgagcg tatccgtcag attgaagcaa aggctttgag aaaactacgc
    21301 caaccaagtc gcagcaaacc gcttcgtgat tttattgaag actaagagtg aggaaaatat
    21361 ggcttataca gaagagcaaa ttgaaaacat caaaacacgg attttaacag ccttggaaga
    21421 agtcatcgac cctgagttgg gaatcgatat tgtcaatctt ggtttgatct atgagattcg
    21481 ttttgacggt gacacagggc aaacagagat tgacatgact ttgacaacta tgggttgtcc
    21541 cttagcagac cttttgacag accagattta tgatgctatg atagaggttc cagaagtaac
    21601 ggatactgag gttaaattag tctggtatcc agcctggaca gttgaaaaaa tgagtcgcta
    21661 tgcccgcatt gccctaggca ttaagtaaac atataaaagc atgtgagaga ctgttggaaa
    21721 agcgaggaaa tttcccctct tttcctctag tctctccttt cttttgctga ttttattcaa
    21781 agaaaatgat ataatagtag ttatggagaa aaagaaatta cgcatcaata tgttgagttc
    21841 aagtgagaaa gtagcaggac agggagtttc aggtgcttac cgtgaattag ttcgtcttct
    21901 tcaccgtgct gccaaggacc aattgattgt tacagaaaat cttccgatcg aggcagatgt
    21961 gactcacttt catacgattg attttcccta ttatttatca accttccaaa agaaacgctc
    22021 agggagaaag attggctatg tgcatttctt gccagctaca cttgagggaa gtttgaaaat
    22081 tccatttttc ttaaagggaa ttgtgaaacg ctatgtattt tctttttaca accggatgga
    22141 gcacttggtt gtggtcaatc ctatgtttat tgaggatttg gtagcagctg gtattccacg
    22201 tgaaaaagtg acctatattc ctaactttgt caacaaggaa aaatggcatc ctctaccaca
    22261 agaagaggta gtcagactgc gcacagatct tggtcttagt gacaatcagt ttatcgtagt
    22321 aggtgctggg caagttcaga aacgtaaagg gattgatgac tttatccgtc tggctgagga
    22381 attgcctcag attaccttta tctgggctgg tggcttctct tttggtggta tgacagatgg
    22441 ttatgaacac tataagaaaa ttatggaaaa tccccctaaa aatttgattt ttccaggcat
    22501 tgtatcgcca gagcggatgc gcgaattgta tgctctagcg gatcttttct tgttgcctag
    22561 ttacaatgag ctctttccta tgactatttt agaagctgcg agttgtgagg ctcctattat
    22621 gttgcgtgat ttagatctct ataaggtgat tttggaggga aattatcggg cgacagcggg
    22681 tagagaagag atgaaagagg ctattttgga atatcaagca aatcctgctg ccttaaaaga
    22741 tctcaaagaa aaggctaaga atatttccag agagtattct gaagagcatc tgttacaaat
    22801 ctggttggac ttttatgaga aacaagccgc tttagggaga aagtaaaaag tgaggtaatc
    22861 tatgcgaatt ggtttattta cagataccta ttttcctcag gtttctggtg ttgcgaccag
    22921 tattcgaacc ttgaaaacag aacttgaaaa gcagggacat gctgttttta tctttacgac
    22981 gacagataag gatgtcaatc gctacgaaga ttggcaaatt atccgcattc caagtgttcc
    23041 tttctttgct tttaaggatc gtcgctttgc ctaccgaggt tttagcaagg cacttgaaat
    23101 tgctaaacag tatcagctag atattatcca tactcagaca gaattttctc ttggcctgtt
    23161 ggggatttgg attgcgcgtg aattgaaaat tccagtcatc catacctatc acacccagta
    23221 tgaagactat gtccattata ttgctaaggg gatgttgatc cgaccgagta tggtcaagta
    23281 tctggttaga ggtttcctgc atgatgtgga tggggttatt tgccctagtg agattgtccg
    23341 tgacttgcta tctgattata aggtcaaggt tgaaaaacgg gtcattccta ctgggattga
    23401 attagccaag tttgagcgtc cggaaatcaa gcaggaaaat ttgaaagaac tgcgtagtaa
    23461 actagggatt caagatggtg aaaagacgtt gcttagtctt tcgagaatct cctatgaaaa
    23521 aaatattcaa gcagttttag tagcctttgc tgatgttctg aaagaggaag acaaggttaa
    23581 actggtagta gctggggatg gcccttatct gaatgacctc aaagagcaag cccagaacct
    23641 agagattcaa gactcagtca tctttacagg gatgattgct cctagtgaga cggctcttta
    23701 ctataaagcg gcggattttt tcatttcggc atcgacaagc gaaacgcaag gtttgaccta
    23761 cttggaaagc ttagccagtg gaacacctgt cattgctcac ggaaatcctt atttgaacaa
    23821 cctcatcagt gataaaatgt ttggaacctt gtactatgga gaacatgatt tggctggtgc
    23881 tattttggaa gccctgattg caacaccaga catgaacgag cataccttat cagagaaatt
    23941 gtatgagatt tcagctgaga actttgggaa acgagtgcat gagttttatc tggatgccat
    24001 tatttcaaat aacttccaga aagatttggc taaagatgat acggtcagtc agcgtatctt
    24061 taagacagtt ttgtatcttc agcaacaggt ggttgctgta cctgtaaaag gatctagacg
    24121 catgttgaag gcttcaaaaa cacagttgat cagtatgaga gactattgga aagaccatga
    24181 agaatagaaa gaggaacagc tatgaaaaaa acaattaatg agaagcggtc gtgataaaaa
    24241 gattgcgggt gtttgtgctg gggtggccca ttatctggat atggatccga ctatcgttca
    24301 agtcatttgg ggtgttctta cttgctgtta cggagctgga attgtagctt acattatttt
    24361 atggattatc gcaccagtag caactgacta ttgaaaacta gctcaattca tgctaagata
    24421 atagaaaata gaatgtaacg aaggagagaa aaatggcatt tggagataat ggaaatcgta
    24481 aaaaaactat gtttgagaaa ataaccttgt ttatcgtgat tatcatgcta gtagcaagtt
    24541 tattgggaat ttttgcaact gcaattggtg ccctcagtaa tctataaaat agattcaaga
    24601 aaatttagtg actgggattt cccagccctt ttttaaagtg agaagaaata atgagtatgt
    24661 ttttagatac agctaagatt aaggtcaagg ctggtaatgg tggcgatggt atggttgcct
    24721 ttcgtcgtga aaaatatgtc cctaatggag gcccttgggg tggtgatggt ggtcgtggag
    24781 gcaatgtggt cttcgttgta gacgaaggac tacgtacctt gatggatttc cgctacaatc
    24841 gtcatttcaa ggctgattct ggtgaaaaag ggatgaccaa agggatgcat ggtcgtggtg
    24901 ctgaggacct tagagttcga gtaccacaag gtacgactgt tcgtgatgcg gagactggca
    24961 aggttttaac agatttgatt gaacatgggc aagaatttat cgttgcccac ggtggtcgtg
    25021 gtggacgtgg aaatattcgt ttcgcgacac caaaaaatcc tgcaccggaa atctctgaaa
    25081 atggagaacc aggtcaggaa cgtgagttac aattggaact aaaaatcttg gcagatgtcg
    25141 gtttagtagg attcccatct gtagggaagt caacactttt aagtgttatt acctcagcta
    25201 agcctaaaat tggtgcctac cactttacca ctattgtacc aaatttaggt atggttcgca
    25261 cccaatcagg tgaatccttt gcagtagccg acttgccagg tttgattgaa ggggctagtc
    25321 aaggtgttgg tttgggaact cagtttctcc gtcacatcga gcgtacacgt gttatccttc
    25381 acatcattga tatgtcagct agcgaaggcc gtgatccata tgaggattac ctagctatca
    25441 ataaagagct ggagtcttac aatcttcgcc tcatggagcg tccacagatt attgtagcta
    25501 ataagatgga tatgcctgag agtcaggaaa atcttgaaga atttaagaaa aaattgtctg
    25561 aaaattatga tgaatttgaa gagttaccag ctatcttccc aatttctgga ttgaccaagc
    25621 aaggtctggc aacactttta gatgctacag ctgaattgtt agacaagaca ccagaatttt
    25681 tgctctacga cgagtccgat atggaagaag aagcttacta tggatttgac gaagaagaaa
    25741 aagcctttga aattagtcgt gatgacgatg cgacatgggt actttctggt gaaaaactca
    25801 tgaaactctt taatatgacc aactttgatc gtgatgaatc tgtcatgaaa tttgcccgtc
    25861 agcttcgtgg tatgggggtt gatgaagccc ttcgtgcgcg tggagctaaa gatggggatt
    25921 tggtccgcat tggtaaattt gagtttgaat ttgtagacta ggagactggt atgggagata
    25981 aaccgatatc tttccgagat gcggatggta attttgtttc cgccgcagac gtttggaatg
    26041 aaaagaaatt ggaagaacta tttaatcgtc tcaatccaaa tcgtgccttg agattggcac
    26101 gaactaaaaa ggaaaatcca tctcagtaaa gaagctaaaa aatcccggct ctttgtcaac
    26161 tgtagtgggt tgaaaaaaag ctaagc
//
LOCUS       DAVHIZ010000146        23814 bp    DNA     linear   BCT 17-JAN-2024
DEFINITION  TPA_asm: Streptococcus pneumoniae isolate 767-7517
            SAMN08166726-rid19298313.guided.029, whole genome shotgun sequence.
ACCESSION   DAVHIZ010000146 DAVHIZ010000000
VERSION     DAVHIZ010000146.1
DBLINK      BioProject: PRJNA514245
            BioSample: SAMN08166726
            Sequence Read Archive: SRR6382468
KEYWORDS    WGS; Third Party Data; TPA; TPA:assembly.
SOURCE      Streptococcus pneumoniae
  ORGANISM  Streptococcus pneumoniae
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 23814)
  AUTHORS   Souvorov,A., Agarwala,R. and Lipman,D.J.
  TITLE     SKESA: strategic k-mer extension for scrupulous assemblies
  JOURNAL   Genome Biol 19 (1), 153 (2018)
   PUBMED   30286803
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 23814)
  CONSRTM   NCBI Pathogen Detection Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2023) National Center for Biotechnology
            Information, National Library of Medicine, National Institutes of
            Health, Bldg 45, Center Drive, Bethesda, MD, USA
COMMENT     The annotation was added by the assembly submitters using the NCBI
            Prokaryotic Genome Annotation Pipeline (PGAP). Information about
            stand-alone PGAP can be found here: https://github.com/ncbi/pgap/
            This draft WGS assembly was generated by running SKESA to generate
            a de-novo assembly. The de-novo assembly was then concatenated with
            contigs generated using a guided assembler using antimicrobial
            resistance genes as baits to comprehensively catalog the set of
            resistance genes in the isolate. Note, some parts of the contigs
            derived from the guided assembler may overlap de-novo contigs, and
            other guided assembler contigs. De-novo contigs can be
            differentiated from guided assembler contigs by their names , which
            include either 'denovo' or 'guided'.
            
            ##Genome-Assembly-Data-START##
            Assembly Date         :: 31-AUG-2023
            Assembly Method       :: SKESA v. 2.2
            Assembly Name         :: PDT001869593.1
            Long Assembly Name    :: NCBI Pathogen Detection Assembly
                                     PDT001869593.1
            Genome Coverage       :: 182x
            Sequencing Technology :: ILLUMINA
            ##Genome-Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Date                   :: 08/31/2023 15:53:37
            Annotation Method                 :: Best-placed reference protein
                                                 set; GeneMarkS-2+
            Annotation Pipeline               :: NCBI Prokaryotic Genome
                                                 Annotation Pipeline (PGAP)
            Annotation Provider               :: NCBI
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA;
                                                 repeat_region
            Annotation Software revision      :: 2021-01-11.build5132
            Genes (total)                     :: 2,117
            CDSs (total)                      :: 2,068
            Genes (coding)                    :: 1,945
            CDSs (with protein)               :: 1,945
            Genes (RNA)                       :: 49
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 1, 2 (5S, 16S)
            tRNAs                             :: 42
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 123
            CDSs (without protein)            :: 123
            Pseudo Genes (ambiguous residues) :: 0 of 123
            Pseudo Genes (frameshifted)       :: 61 of 123
            Pseudo Genes (incomplete)         :: 50 of 123
            Pseudo Genes (internal stop)      :: 37 of 123
            Pseudo Genes (multiple problems)  :: 22 of 123
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..23814
                     /organism="Streptococcus pneumoniae"
                     /mol_type="genomic DNA"
                     /submitter_seqid="SAMN08166726-rid19298313.guided.029"
                     /serotype="19 F"
                     /isolate="767-7517"
                     /isolation_source="nasopharyngeal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:1313"
                     /country="Russia: Saint-Petersburg"
                     /collection_date="2015-10-13"
                     /collected_by="Pediatric Research and Clinical Center for
                     Infectious Diseases"
                     /note="genotype: ST 236"
     gene            593..907
                     /locus_tag="VVO18_002092"
     CDS             593..907
                     /locus_tag="VVO18_002092"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006148869.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU5587152.1"
                     /translation="MELKFVIPNMEKTFGNLEFAGEDKVVQRRINGRLTVLSRSYNLY
                     SDVQRADDIVVVLPAEAGEKHFGFEERVKLVNPRITAEGYKIGTRGFTNYLLHADDMI
                     KE"
     gene            923..1309
                     /locus_tag="VVO18_002093"
     CDS             923..1309
                     /locus_tag="VVO18_002093"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000985015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YdcP family protein"
                     /protein_id="HEU5587153.1"
                     /translation="MMRLANGIVLDKDTTFGELKFSALRREVRIQNEDGSVSDEIKER
                     TYDLKSKGQGRMIQVSIPASVPLKEFDYNARVELINPIADTVATATYQGADVDWYIKA
                     DDIVLTKDSSSFKAQPQAKKEPTQDK"
     gene            1338..2723
                     /locus_tag="VVO18_002094"
     CDS             1338..2723
                     /locus_tag="VVO18_002094"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000813487.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA translocase FtsK"
                     /protein_id="HEU5587154.1"
                     /translation="MKQRGKRIRPSGKDLVFHFTIASLLPVFLLVVGLFHVKTIQQIN
                     WQDFNLSQADKIDIPYLIISFSVAILICLLVAFVFKRVRYDTVKQLYHRQKLAKMILE
                     NKWYESEQVKTEGFFKDSAGRTKEKITYFPKMYYRLKNGLIQIRVEITLGKYQDQLLH
                     LEKKLESGLYCELTDKELKDSYVEYTLLYDTIASRISIDEVEAKDGKLRLMKNVWWEY
                     DKLPHMLIAGGTGGGKTYFILTLIEALLHTDSKLYILDPKNADLADLGSVMANVYYRK
                     EDLLSCIETFYEEMMKRSEEMKQMKNYKTGKNYAYLGLPAHFLIFDEYVAFMEMLGTK
                     ENTAVMNKLKQIVMLGRQAGFFLILACQRPDAKYLGDGIRDQFNFRVALGRMSEMGYG
                     MMFGSDVQKDFFLKRIKGRGYVDVGTSVISEFYTPLVPKGYDFLEEIKKLSNSRQSTQ
                     ATCEAEVAGVD"
     gene            2726..2878
                     /locus_tag="VVO18_002095"
     CDS             2726..2878
                     /locus_tag="VVO18_002095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879507.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5587155.1"
                     /translation="MLAGVAIATPALNPPYLTGGYKSTGNSQKNIRKSFGYKGFTKFQ
                     RMSNGL"
     gene            2901..4106
                     /locus_tag="VVO18_002096"
     CDS             2901..4106
                     /locus_tag="VVO18_002096"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000398284.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="HEU5587156.1"
                     /translation="MEGFLLNEQTWLQHLKEKRLAYGLSQNRLAVATGITRQYLSDIE
                     TGKVKPSEDLQQSLWEALERFNPDAPLEMLFDYVRIRFPTTDVQQVVENILQLKLSYF
                     LHEDYGFYSYSEHYALGDIFVLCSHELDKGVLVELKGRGCRQFESYLLAQQRSWYEFF
                     MDVLVAGGVMKRLDLAINDKTGILNIPVLTEKCQQEECISVFRSFKSYRSGELVRKEE
                     KECMGNTLYIGSLQSEVYFCIYEKDYEQYKKNDIPIEDAEVKNRFEIRLKNERAYYAV
                     RDLLVYDNPEHTAFKIINRYIRFVDKDDSKPRSDWKLNEEWAWFIGNNRERLKLTTKP
                     EPYSFQRTLNWLSHQVAPTLKVAIKLDEINQTQVVKDILDHAKLTDRHKQILKQQSVK
                     EQDVITTKK"
     gene            4149..4370
                     /locus_tag="VVO18_002097"
     CDS             4149..4370
                     /locus_tag="VVO18_002097"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464634.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587157.1"
                     /translation="MNFGQNLYNWFLSNAQSLVLLAIVVIGLYLGFKREFSKLIGFLI
                     IAIIAVGLVFNAAGVKDILLELFNRIIGA"
     gene            4487..4984
                     /locus_tag="VVO18_002098"
     CDS             4487..4984
                     /locus_tag="VVO18_002098"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000342537.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antirestriction protein ArdA"
                     /protein_id="HEU5587158.1"
                     /translation="MDDMQVYIANLGKYNEGELVGAWFTFPIDFEEVKEKIGLNDEYE
                     EYAIHDYELPFTVDEYTSIGELNRLWEMVSELPEELQSELSALLTHFSSIEELSEHQE
                     DIIIHSDCDDMYDVARYYIEETGALGEVPASLQNYIDYQAYGRDLDLSGTFISTNHGI
                     FEIVY"
     gene            4959..5465
                     /locus_tag="VVO18_002099"
     CDS             4959..5465
                     /locus_tag="VVO18_002099"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016897981.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5587159.1"
                     /translation="MGFLKSSIKSVGTLLLADFLFYGVAQSATPIFYERIDYMKKIRS
                     YTSIWSVEKVLYSINDFRLPFPITFTQMTWFVVSLFAVMILGNLPPLSMIEGAFLKYF
                     GIPVAFTWFMSTKTFDGKKPYGFLKSVIAYALRPKLTYAGKKVTLGRNQPQEAITAVR
                     SEFYGISN"
     gene            5449..7896
                     /locus_tag="VVO18_002100"
     CDS             5449..7896
                     /locus_tag="VVO18_002100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_464631.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="HEU5587160.1"
                     /translation="MAYPIKYIENNLVWNKDGECYAYYELVPYNYSFLSPEQKIQVHD
                     SFRQLIAQNRDGKIHALQISTESSIRSAQERSKNEVTGKLKAVAYDKIDQQTDALISM
                     IGENQVNYRFFIGFKLLLNDQEFSMKSLTVEAKNALSDFVYDVNHKLMGDFVSMSNDE
                     ILRFQKMEKLLENKISRRFKIRRLDKDDFGYLIEHLYGQTGTAYEEYEYHLSKKKLDN
                     ETLIKYYDLIKPTRCLVEEKQRYLKIQQEDETVYVAYFTINSIVGELDFPSSEIFYYQ
                     QQQFTFPIDTSMNVEIVANRKALSTVRNKKKELKDLDNHAWQSDNETSSNVAEALESV
                     NELETNLDQSKESMYKLSYVVRVSANDLDELKRRCNEVKDFYDDLSVKLVRPFGDMLG
                     LHEEFLPASKRYMNDYIQYVTSDFLAGLGFGATQMLGENEGIYVGYSLDTGRNVYLKP
                     ALASQGVKGSVTNALASAFVGSLGGGKSFANNLIVYYAVLYGAQAVIVDPKAERGRWK
                     ETLPEISHEINIVTLTSDEKNKGLLDPYVIMKNPKDSESLAIDILTFLTGISSRDGER
                     FPILRKAIRAVTNSEVRGLMKVIEELRVENTPLSTSIADHIESFTDYDFAHLLFSNGY
                     VEQSISLEKQLNIIQVADLVLPDKETSFEEYTTMELLSVAMLIVISTFALDFIHTDRS
                     IFKIVDLDEAWSFLQVAQGKTLSMKLVRAGRAMNAGVYFVTQNTDDLLDEKLKNNLGL
                     KFAFRSTDLNEIKKTLAFFGVDPEDENNQKRLRDLENGQCLISDLYGRVGVIQFHPVF
                     EELLHAFDTRPPVRKEV"
     gene            7899..10076
                     /locus_tag="VVO18_002101"
     CDS             7899..10076
                     /locus_tag="VVO18_002101"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017646277.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YtxH domain-containing protein"
                     /protein_id="HEU5587161.1"
                     /translation="MKPSIVNRIKSNWTLKRLGKVAMTVAFTLVIAIFLLAMLGTVVQ
                     AAGLVDDTVNVANEYSRYPLENYQLDFYVDNSWGWLPWNWSDGIGKQVMYGLYAITNF
                     IWTISLYVSNATGYLVQEAYSLDFISATADSIGKNMQTLAGVSANGFSTEGFYVGFLL
                     LLILVLGVYVAYTGLIKRETTKAIHAIMNFVLVFILSASFIAYAPDYIKKINDFSSDI
                     SNASLSLGTKIVMPHSDSQGKDSVDLIRDSLFSIQVQQPWLLLQYNSSDIESIGIDRV
                     ESLLSTSPDSNNGEDREKIVAEEIEDRSNTNLTITKTINRLGTVFFLFVFNIGISIFV
                     FLLTGIMIFSQVLFIIYAMFLPVSFILSMIPSFDGMSKRAITKLFNTILTRAGITLII
                     TTAFSISTMLYTLSAGYPFFLIAFLQIVTFAGIYFKLGDLMSMFSLQSNDSQSVGSRV
                     MRKPRMLMHAHMHRLQRKLGRSMTTLGAGSAIVTGKKGQSGSGSSARTQADHSRPDGK
                     EKSTLGKRIGQTIGTVADTKDRMVDTASGLKEQVKDLPTNARYAVYQGKSKVKENVRD
                     LTSSISQTKADRASGRKEQQEQRRKTIAKRRSEMEQVKQKKQPASSVHERPTTRQEQY
                     HDEQTSKQSNIQTSYKESQQAKQERPAVKSDFSSPKVERQGNTVQEKTVQKPATSTTT
                     ADRTSQRPITKERPSTVQRVPLQNTRSRPPIKTATIKKVGKKP"
     gene            10073..11074
                     /locus_tag="VVO18_002102"
     CDS             10073..11074
                     /locus_tag="VVO18_002102"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional lysozyme/C40 family peptidase"
                     /protein_id="HEU5587162.1"
                     /translation="MKLKTLVIGGSGLFLMVFSLLLFVAILFSDEQDSGISNIHYGGV
                     NVSAEVLAHKPMVEKYAKEYGVEEYVNILLAIIQVESGGTAEDVMQSSESLGLPPNSL
                     STEESIKQGVKYFSELLASSERLSVDLESVIQSYNYGGGFLGYVANRGNKYTFELAQS
                     FSKEYSGGEKVSYPNPIAIPINGGWRYNYGNMFYVQLVTQYLVTTEFDDDTVQAIMDE
                     ALKYEGWRYVYGGASPTTSFDCSGLTQWTYGKAGINLPRTAQQQYDVTQHIPLSEAQA
                     GDLVFFHSTYNAGSYITHVGIYLGNNRMFHAGDPIGYADLTSPYWQQHLVGAGRIKQ"
     gene            11071..12003
                     /locus_tag="VVO18_002103"
     CDS             11071..12003
                     /locus_tag="VVO18_002103"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /protein_id="HEU5587163.1"
                     /translation="MRKEDLMMKFRKNQNKEKQIPKEKKPRVYKVNPHKKVVIALWVL
                     LGLSFSFAIFKHFTAIDTHTIHETTIIEKEYVDTHHVENFVENFAKVYYSWEQSDKSI
                     DNRMESLKGYLTDELQALNVDTVRKDIPVSSSVRGFQIWTVEPTGDNEFNVTYSVDQL
                     ITEGENTKTVHSAYIVSVYVDGSGNMVLVKNPTITNIPKKSSYKPKAIESEGTVDSIT
                     TNEINEFLTTFFKLYPTATASELSYYVNDGILKPIGKEYIFQELVNPIHNRKDNQVTV
                     SLTVEYIDQQTKATQVSQFDLVLEKNGSNWKIIE"
     gene            12322..14241
                     /gene="tet(M)"
                     /locus_tag="VVO18_002104"
     CDS             12322..14241
                     /gene="tet(M)"
                     /locus_tag="VVO18_002104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011117014.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tetracycline resistance ribosomal protection
                     protein Tet(M)"
                     /protein_id="HEU5587164.1"
                     /translation="MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTD
                     NTLLERQRGITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAK
                     DGVQAQTRILFHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVEL
                     YPNMCVTNFTESEQWDTVIEGNDDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYH
                     GSAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLH
                     LRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLP
                     QRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSFLG
                     KVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVS
                     PLPLGSGMQYESSVSLGYLNQSFQNAVMEGIRYGCEQGLYGWNVTDCKICFKYGLYYS
                     PVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIV
                     DTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGRSVCLTELKGYHVTTGEPVCQPRRP
                     NSRIDKVRYMFNKIT"
     gene            14605..14850
                     /locus_tag="VVO18_002105"
     CDS             14605..14850
                     /locus_tag="VVO18_002105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001842373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587165.1"
                     /translation="MRQIGVSYSGFVDESYTLLSLFDDVEQIEKDNRLQTAIDVVREQ
                     FGFLAIQKGTVLTEGSRNIERSKLIGGHSAGGLEGLK"
     gene            14847..15182
                     /locus_tag="VVO18_002106"
     CDS             14847..15182
                     /locus_tag="VVO18_002106"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000806925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="imsC-like protein"
                     /protein_id="HEU5587166.1"
                     /translation="MKQEKNTVQFSEIRSKGCNDIEMLERFLHGIVETATSKLRQRKL
                     KTTEISIRLVHAKSENRLPLEFTFSIKPTSSSVIIYTEVINRFKECYTGGGIQGFTIQ
                     FDKNTLASA"
     gene            15195..15563
                     /locus_tag="VVO18_002107"
     CDS             15195..15563
                     /locus_tag="VVO18_002107"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004254363.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587167.1"
                     /translation="MIDRSYLPFQSAREYQDTKMQKWMGFFLSEHASALSDDTNKVTY
                     MSDLSLEKKLLLLSQVYAGQLRTRIQVIEKNKRVSYTGTIPSLTKDFILIKTTTGHIN
                     LKLKDIISIELVEEVLYESA"
     gene            15550..15849
                     /locus_tag="VVO18_002108"
     CDS             15550..15849
                     /locus_tag="VVO18_002108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018374804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="HEU5587168.1"
                     /translation="MNQLEFQRNHLQMDYYSESYQDFERDFYRYSNMNIPLTFLTDDI
                     LKTMATSRKNYFVLNKEKSRDNRDHFFIFEVSTVDENPLIYHYTYKKTTIYLAEK"
     gene            complement(15967..17430)
                     /gene="msr(D)"
                     /locus_tag="VVO18_002109"
     CDS             complement(15967..17430)
                     /gene="msr(D)"
                     /locus_tag="VVO18_002109"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000420317.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-F type ribosomal protection protein Msr(D)"
                     /protein_id="HEU5587169.1"
                     /translation="MELILKAKDIRVEFKGRDVLDINELEVYDYDRIGLVGANGAGKS
                     TLLRVLLGELTPPGCKMNRLGELAYIPQLDEVTLQEEKDFALVGKLGVEQLNIQTMSG
                     GEETRLKIAQALSAQVHGILADEPTSHLDREGIDFLIGQLKYFTGALLVISHDRYFLD
                     EIVDKIWELKDGKITEYWGNYSDYLRQKEEERKSQAAEYEQFIAERARLERAAEEKRK
                     QARKIEQKAKGSSKKKSTEDGGRLAHQKSIGSKEKKMYNAAKTLEHRIAALGKVEAPE
                     GIRRIRFRQSKALELHNPYPIVGAEINKVFGDKALFENASFQIPLGAKVALTGGNGIG
                     KTTLIQMILNHEEGISISPKAKIGYFAQNGYKYNSNQNVMEFMQKDCDYNISEIRSVL
                     ASMGFKQNDIGKSLSVLSGGEIIKLLLAKMLMGRYNILIMDEPSNFLDIPSLEALEIL
                     MKEYTGTIVFITHDKRLLENVADVVYEIRDKKINLKH"
     gene            complement(17550..18767)
                     /gene="mef(A)"
                     /locus_tag="VVO18_002110"
     CDS             complement(17550..18767)
                     /gene="mef(A)"
                     /locus_tag="VVO18_002110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012102963.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide efflux MFS transporter Mef(A)"
                     /protein_id="HEU5587170.1"
                     /translation="MEKYNNWKRKFYAIWAGQAVSLITSAILQMAIIFYLTEKTGSAM
                     VLSMASLVGFLPYAILGPAIGVLVDRHDRKKIMIGADLIIAAAGAVLAIVAFCMELPV
                     WMIMIVLFIRSIGTAFHTPALNAVTPLLVPEEQLTKCAGYSQSLQSISYIVSPAVAAL
                     LYSVWDLNAIIAIDVLGAVIASITVAIVRIPKLGNQVQSLEPNFIREMKEGVVVLRQN
                     KGLFALLLLGTLYTFVYMPINALFPLISMEHFNGTPVHISITEISFAFGMLAGGLLLG
                     RLGGFEKHVLLITSSFFIMGTSLAVSGILPPNGFVIFVVCCAIMGLSVPFYSGVQTAL
                     FQEKIKPEYLGRVFSLIGSIMSLAMPIGLILSGFFADKIGVNHWFLLSGILIIGIAIV
                     CQMITEVRKLDLK"
     gene            complement(19153..19323)
                     /locus_tag="VVO18_002111"
     CDS             complement(19153..19323)
                     /locus_tag="VVO18_002111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000873143.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombinase"
                     /protein_id="HEU5587171.1"
                     /translation="MKYFEVELENPDEFLKLQTEDFVKANRLLLRKIIQSVTVYEENF
                     VISFKSGIELEV"
     gene            19845..20036
                     /locus_tag="VVO18_002112"
     CDS             19845..20036
                     /locus_tag="VVO18_002112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001860868.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cysteine-rich KTR domain-containing protein"
                     /protein_id="HEU5587172.1"
                     /translation="MTSKLTASTCPVCGNKTRLKIREDTELKKFPLYCPKCRQENLIE
                     IKQFKVTVITEPDAKTQSR"
     gene            complement(20096..20449)
                     /locus_tag="VVO18_002113"
     CDS             complement(20096..20449)
                     /locus_tag="VVO18_002113"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001227347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5587173.1"
                     /translation="MRKKEDKYDFRAFGLAIKEARLKRGLTREQVGALIEIDPRYLTN
                     IENKGQHPSIQVLYDLVSLLHVSVDEFFLPANNLVKSTRRLQIEKYMDSFTDKELSLM
                     ESLASGINEARNIED"
     gene            20954..21376
                     /locus_tag="VVO18_002114"
     CDS             20954..21376
                     /locus_tag="VVO18_002114"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006733729.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="HEU5587174.1"
                     /translation="MKPSSFQTTIENQFDYICKRAMEDERKNYMLYLSRIAKREVSFS
                     DVGDYLVSQFATTDNYSTDFQIFTLNGLSVGVENDLLSEALRELPDKKREILLLFYFM
                     DMSDSEIADLLKLNRSTVYRHRTSGLALIKKFMEEFEE"
     gene            21373..21603
                     /locus_tag="VVO18_002115"
     CDS             21373..21603
                     /locus_tag="VVO18_002115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002411750.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="HEU5587175.1"
                     /translation="MKTQYPMIPFPLIVKATDGDTEAINQILHHYRGYITKRSLRLMK
                     DEYGNQSMVVDEVLRGRMETRLITKILSFEIK"
     gene            22064..22267
                     /locus_tag="VVO18_002116"
     CDS             22064..22267
                     /locus_tag="VVO18_002116"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006730246.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="excisionase"
                     /protein_id="HEU5587176.1"
                     /translation="MKQTDIPIWERYTLTIEEASKYFRIGENKLRRLAEENKNANWLI
                     MNGNRIQIKRKQFEKIIDTLDAI"
     gene            22349..23566
                     /locus_tag="VVO18_002117"
     CDS             22349..23566
                     /locus_tag="VVO18_002117"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020220015.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="HEU5587177.1"
                     /translation="MSEKRRDNKGRILKTGESQRKDGRYLYKYIDSFGEPQFVYSWKL
                     VATDRVPAGKRDCISLREKIAELQKDIHDGIDVVGKKMTLCQLYAKQNAQRPKVRKNT
                     ETGRKYLMDILKKDKLGVRSIDSIKPSDAKEWAIRMSENGYAYQTINNYKRSLKASFY
                     IAIQDDCVRKNPFDFQLKAVLDDDTVPKTVLTEEQEEKLLAFAKADKTYSKNYDEILI
                     LLKTGLRISEFGGLTLPDLDFENRLVNIDHQLLRDTEIGYYIETPKTKSGERQVPMVE
                     EAYQAFKRVLANRKNDKRVEIDGYSDFLFLNRKNYPKVASDYNGMMKGLVKKYNKYNE
                     DKLPHITPHSLRHTFCTNYANAGMNPKALQYIMGHANIAMTLNYYAHATFDSAMAEMK
                     RLNKEKQQERLVA"
BASE COUNT         7754 a         4406 c         4684 g         6970 t
ORIGIN      
        1 aaagaaaggg gtttcattgc atgagaaaaa aacgtggaat taaaaaatta gttacatttg
       61 cattactagg tgtttttatg tttagtaata caattcctta ccaacagttt attcagaaga
      121 ataaacaatt ggaagttcga gtacaatcac aaaaggagtc caatggtctt gatgttggga
      181 aggctgatta gttgattaaa tgatgaaaat actaattaac tatatggtat ttctgtttta
      241 tctaattttt aattagaaaa atagcataaa aatctagtta tccgcataaa aactggactt
      301 atcacacttt atcaaggtca aaaccactca atttactact aatttactac ttatgaatga
      361 gctttgatac gacgatttat ccttgaaaag tgaagatata aagatacttc caataaaatt
      421 tgaatattta ataggtagac acttcaaaaa atgaggtgtc tattttttta cccgattttg
      481 aaaggaagtg aacttatgaa aacaaaaaat caagaatcaa aaggtcgttc cccactcttt
      541 aagaccatca aacattcatt cagccaataa aaaagaaagg ataggtaaaa atatggaact
      601 taaatttgtg attcccaaca tggaaaaaac attcggcaat ttagaatttg ctggcgagga
      661 taaagtcgtt cagcgaagaa tcaacggacg gctaactgtc ttatcaagaa gctataatct
      721 ctattctgat gttcaaagag cagatgatat tgtggtggtg cttcctgctg aagctggcga
      781 aaaacatttc ggctttgagg aacgtgtgaa gttagtcaat ccacgtatta ccgcagaggg
      841 ctacaaaatc ggcactcgtg gttttacaaa ttacctttta catgctgacg acatgataaa
      901 agaataaaga aagagaggaa aaatgatgag attagcaaat ggcattgtat tagataaaga
      961 cacgactttt ggagaattga aattctctgc tctacgtcgt gaagtgagaa tccaaaatga
     1021 agacgggtcg gtttcagatg aaatcaagga acgtacctat gacttaaaat ccaaaggaca
     1081 aggacgcatg attcaagtaa gtattcctgc cagcgtgcct ttgaaagagt ttgattataa
     1141 cgcacgggtg gaacttatca atcccattgc ggacaccgtt gctactgcca cctatcaagg
     1201 agcagatgtt gactggtata tcaaggcaga cgatattgtg ctgacaaagg attctagttc
     1261 attcaaagct caaccacaag caaagaaaga accgacacaa gacaaatagt cgctaggtag
     1321 aaaggagact ttttcgcatg aaacagcgtg gtaaaaggat tcgcccatct ggtaaagatt
     1381 tagtctttca ttttacgata gcgtcactcc tgcctgtttt cctgctggtt gtcggactgt
     1441 ttcatgtgaa gacaatccag cagatcaact ggcaggattt taacctatca caagcagata
     1501 agattgacat tccctattta attatcagtt tcagtgtcgc aattcttatc tgcttgctgg
     1561 tagcgtttgt attcaaacgg gttcgctatg atacggttaa acaactttac caccgtcaaa
     1621 aactggcaaa gatgatactt gaaaacaagt ggtatgaatc tgaacaggtc aaaacagagg
     1681 gtttctttaa agatagtgct ggtcgtacaa aggaaaagat aacctacttc cctaaaatgt
     1741 attatcgact taaaaatggc ttgatacaga tacgggtgga aatcacgctg ggaaaatatc
     1801 aagaccaact cttacacttg gaaaagaaat tagagagtgg cttgtactgt gagctgacgg
     1861 ataaagagtt aaaggattcc tatgtggaat atactttgct ctatgacacc atagccagtc
     1921 gtatttctat tgatgaagta gaagctaaag atggtaaact tcgcttaatg aaaaacgtat
     1981 ggtgggaata tgataagctc cctcatatgt tgattgctgg tggtacaggt ggcggtaaaa
     2041 cttactttat actgacactg attgaagcct tgcttcatac agattcaaaa ctgtatattc
     2101 ttgacccgaa aaatgctgac cttgcggact taggttctgt gatggcaaat gtctactata
     2161 gaaaagaaga cttgctttct tgcattgaaa cattctatga agaaatgatg aaacgtagtg
     2221 aggaaatgaa gcagatgaag aactataaga ctggcaaaaa ttatgcttac ttaggtctcc
     2281 cggcacactt cttaatcttt gatgaatacg tcgctttcat ggaaatgctg ggaacaaaag
     2341 aaaacaccgc agttatgaat aagctgaaac agattgtcat gttaggtcgt caagctggct
     2401 tctttctaat actggcttgt caacgtccag acgcaaaata tttaggcgac ggaatccgtg
     2461 atcagtttaa tttcagagtg gctttaggtc gtatgtctga aatgggctat ggcatgatgt
     2521 ttggcagtga cgtacaaaag gatttcttct taaagcgaat caaaggtcgt ggctatgttg
     2581 atgtaggaac aagtgtcata tcagagtttt atactcccct tgtaccaaaa ggatatgatt
     2641 tcttggagga aattaaaaag ttatccaaca gcagacagtc cacgcaggcg acgtgcgaag
     2701 cggaagtcgc aggtgtggac tgatcttgct ggctggtgtg gcaatagcca cgccagcact
     2761 taaccccccg tatctaacag gggggtacaa atcgacagga aacagtcaaa aaaacattag
     2821 aaaatccttt ggttacaagg gatttacaaa atttcagcgt atgtcaaatg ggctttaaaa
     2881 gttgacatac gcctttttga ttggagggat ttttactgaa tgaacaaact tggttacagc
     2941 atttaaaaga aaaacgcttg gcttatggac tatctcaaaa ccgtttagct gttgcgactg
     3001 gtattacaag gcagtatcta agcgatattg aaacaggaaa agtcaagcca tcagaggatt
     3061 tacagcagtc cctttgggaa gctctggaac gcttcaatcc cgacgctccc cttgaaatgc
     3121 tgtttgatta tgtaaggatt cgctttccga caacagacgt acagcaggtg gtcgaaaaca
     3181 tcttacaact gaaactgtcc tattttcttc atgaggacta tggtttctat tcttattcag
     3241 agcattatgc tttaggcgac atattcgtcc tttgctccca tgaactggac aaaggagttc
     3301 tggtggaatt gaaaggtcgt gggtgcagac aatttgaaag ctatcttctg gcacaacaaa
     3361 gaagctggta tgagttcttt atggacgttt tggtggctgg cggtgtgatg aaacgccttg
     3421 accttgccat taacgataag acagggattt tgaatatccc tgtactcact gaaaagtgcc
     3481 aacaggaaga atgtatctcc gtcttccgca gttttaaaag ctatcgcagt ggcgaactgg
     3541 tacgcaaaga ggaaaaggaa tgtatgggaa acaccctcta tatcggttca ttacaaagtg
     3601 aagtttattt ctgtatctat gaaaaggact acgagcagta caagaaaaat gatattccca
     3661 ttgaagacgc agaagtaaaa aaccgttttg agattcgatt gaaaaatgag cgtgcctatt
     3721 atgcagtccg tgatttactc gtctatgaca atccagagca taccgccttt aaaattatca
     3781 atcggtatat ccgttttgta gataaagacg attccaaacc tcgttctgat tggaaactga
     3841 atgaagaatg ggcttggttt attgggaaca atcgtgaacg attaaaacta accacaaaac
     3901 cagagcctta ctccttccaa aggacgctga actggctatc tcatcaagtt gccccgacct
     3961 taaaggttgc gattaaactt gatgaaatca accagacgca ggttgtaaaa gacattctcg
     4021 accatgcgaa actgacagac cgacacaagc agattttgaa gcaacagtca gtaaaagaac
     4081 aggacgtgat aacaacaaaa aaataactca aatacaaatt cattgaatat agagaggaga
     4141 acatttttat gaattttgga caaaaccttt ataactggtt tctatcaaac gctcaatcac
     4201 tggtgctttt agcaatcgtt gtgattggct tgtatcttgg cttcaagcgt gagtttagca
     4261 aactgattgg ctttttaatt attgcgatta ttgcggttgg cttagtcttc aacgctgctg
     4321 gagtaaaaga cattttacta gagctattca atcgcattat tggtgcttaa ataaaaccgt
     4381 tcttttgtgg aatataagtg gttttcttat gttccgcaaa ggaatggtac accaaacgaa
     4441 gtgcggtagg gatttttgaa tctctacaaa gaaaggacgt gaatatatgg acgatatgca
     4501 agtctatatt gcgaatttag gcaaatacaa tgagggcgaa ttggtcggtg cgtggtttac
     4561 ctttcccatt gactttgagg aagtcaaaga gaaaatcggc ttgaatgatg aatatgagga
     4621 atacgccatt catgactacg agttaccctt tacggttgac gaatacactt ccattggcga
     4681 actcaatcga ctatgggaaa tggtatcgga attacccgaa gaattacaat cggagctatc
     4741 tgctctgctc actcattttt caagcattga agaactaagc gaacatcaag aggatattat
     4801 cattcattcc gattgtgatg atatgtatga cgtggcacgc tactacattg aagaaacggg
     4861 tgctttaggc gaagtaccag ctagtcttca aaactatatt gattatcaag cctatggtcg
     4921 ggatttagac ctttcaggaa cgtttatctc aaccaatcat gggatttttg aaatcgtcta
     4981 ttaaatctgt cggtacatta ctactggcag attttctatt ttacggggtg gctcaatcag
     5041 ctacccctat tttttatgaa aggattgatt acatgaagaa aatacgaagc tataccagta
     5101 tctggtctgt ggaaaaggta ctgtattcta tcaatgattt tagacttccg tttcccataa
     5161 cctttacgca aatgacatgg tttgtcgtgt cactctttgc agtgatgata cttggcaact
     5221 tgccccctct ttccatgata gagggagcat ttctcaaata ctttgggatt cctgtggctt
     5281 tcacatggtt tatgtctaca aaaacttttg atggtaaaaa gccttatgga tttttgaagt
     5341 ctgtcattgc ttatgcactg cgaccaaagc tgacctatgc aggaaaaaaa gtaacgcttg
     5401 gcagaaacca gccacaagaa gccattacag cagttaggag tgaattttat ggcatatcca
     5461 attaaataca ttgaaaacaa tctcgtctgg aataaagacg gggaatgtta tgcttactat
     5521 gagcttgttc cttacaatta ctcatttcta agtccagaac agaaaataca agtgcatgat
     5581 tctttcagac agcttatcgc acaaaatcgt gatggcaaaa ttcatgcttt acaaatcagt
     5641 acagaatcca gcatacgttc tgcacaagag cgttccaaaa atgaagtcac tggcaagctc
     5701 aaagcggttg cctatgacaa aatcgaccaa cagacagacg ctttaatatc catgattggc
     5761 gaaaatcaag tgaactaccg tttctttatc ggctttaagt tgcttctcaa cgatcaggag
     5821 ttttctatga aaagtcttac cgttgaagca aaaaatgctt tgtctgattt tgtctatgat
     5881 gtgaaccata agctgatggg cgattttgtt agtatgagta atgatgaaat cctgcgtttt
     5941 cagaagatgg aaaagctctt agaaaataaa atctctcgtc gtttcaaaat ccgcaggtta
     6001 gataaggacg acttcggcta tctgattgaa cacctttacg gacagacagg cactgcctat
     6061 gaagagtatg agtaccatct atcaaagaaa aagctggata atgaaacgct gattaaatac
     6121 tatgacttga ttaagcctac tcgctgtttg gtggaagaaa aacagcgata tttgaaaatc
     6181 cagcaggaag atgaaaccgt ctatgtagct tactttacca ttaacagcat tgtcggagaa
     6241 ctggacttcc cgtcctctga aatcttctac taccagcaac agcaatttac attcccgatt
     6301 gatacgtcaa tgaatgtgga aattgtagcg aatcgtaaag ccctatctac tgtccgcaat
     6361 aaaaagaaag aactgaaaga cttggataac cacgcttggc aaagtgataa tgaaaccagc
     6421 tccaatgtgg cggaagctct ggaaagtgtg aatgagctgg aaaccaattt agaccaaagc
     6481 aaggaatcta tgtacaagct gtcttatgtg gtaagggtat cagcaaatga tcttgacgaa
     6541 ctcaaacgtc gttgtaatga agtgaaagat ttttatgacg atttaagcgt aaaactggta
     6601 cgaccatttg gggatatgct cggcttacat gaagaatttt tacctgccag caagcgttat
     6661 atgaatgatt atattcaata cgtgacctct gatttcctcg ctggtttagg ttttggtgct
     6721 actcaaatgc tgggggaaaa tgaggggatt tatgttggct acagcttaga tactggacgc
     6781 aatgtctatc tgaaacctgc tcttgccagt caaggggtta agggttcagt aaccaatgcg
     6841 ttagcgtcgg cttttgttgg ttcgctgggt ggtggtaaat cctttgcgaa taaccttatc
     6901 gtctattatg cggtgcttta tggggcacaa gcagtgattg tagacccaaa agcagaacgt
     6961 ggcagatgga aagaaacctt gccagagatt tcccatgaaa tcaatatcgt cactctgact
     7021 tctgatgaga aaaacaaagg cttacttgac ccttatgtga ttatgaaaaa tcccaaagat
     7081 tctgaatcac tggctattga tattctgaca ttccttacgg ggatttcctc tcgtgatggg
     7141 gaacgcttcc caatccttag aaaagccatt cgtgcagtaa ccaatagtga agtacgaggg
     7201 ttgatgaaag tgattgagga attacgggtt gagaatacgc cactaagtac cagtatagcc
     7261 gaccatatcg aaagttttac agactatgac tttgcacatt tattattcag taatggttat
     7321 gtggagcagt ctatcagctt agaaaaacaa ctgaacatta tacaggttgc ggacttggta
     7381 cttcccgaca aggaaacttc ctttgaggaa tataccacta tggagctttt atccgttgct
     7441 atgctgattg tcattagtac ctttgcttta gactttatcc atacagaccg aagcattttc
     7501 aagattgtag atttagacga agcatggagc tttttacagg tagcacaagg aaaaacacta
     7561 tctatgaagc tggttcgggc tggtcgtgct atgaacgctg gagtatattt cgtgacccaa
     7621 aatacagacg acctcttaga tgaaaaactg aaaaataacc tcggcttaaa atttgcattt
     7681 cgttccactg accttaacga gattaaaaag accttagcct tttttggtgt agacccagag
     7741 gacgaaaaca atcagaagcg attgcgtgat ttggaaaacg ggcaatgcct tatcagtgat
     7801 ttatatggtc gtgtcggtgt gatacagttc caccctgtat ttgaagaact gctccatgcc
     7861 tttgatacca gaccacctgt gcgaaaagag gtgtaaatgt gaaaccatca atagtaaaca
     7921 gaataaaatc aaactggacg ctgaaacgtc taggtaaagt ggcaatgaca gtggctttca
     7981 cacttgtgat tgccattttt cttttagcca tgctgggaac ggtggttcaa gctgcgggct
     8041 tggtagatga tacggtcaat gtggcaaatg aatacagccg atacccactt gaaaactatc
     8101 aactggattt ttatgtggat aatagctggg gctggcttcc gtggaactgg tcggacggga
     8161 ttggaaaaca ggtcatgtat ggactatatg ccattaccaa ttttatttgg acaatcagtt
     8221 tgtatgtttc caatgcgaca ggttacttag tacaggaagc ctattcctta gacttcattt
     8281 ccgctacagc agattccatt ggtaagaata tgcagacctt agctggtgtg agtgcaaacg
     8341 gattttcaac agagggtttc tatgttggat tcctcttact cttgattttg gttcttgggg
     8401 tttatgttgc ctatacggga ctgataaaga gagaaaccac aaaggcaatt catgccatta
     8461 tgaattttgt gctggtgttt atcctatcgg cttcctttat tgcctacgct cccgactaca
     8521 ttaaaaaaat caatgacttt tcatcagaca tcagtaatgc cagtttatca cttggcacga
     8581 agattgtcat gccccattcc gatagtcaag gcaaggacag cgtggactta atcagagata
     8641 gcctgttttc catacaggtt cagcaaccgt ggctactgct tcaatacaac agttcagaca
     8701 ttgaaagtat cggtattgac cgtgtggaaa gcctgctctc caccagccca gattccaaca
     8761 atggcgaaga cagagaaaaa attgttgcgg aagaaattga agacagaagc aataccaatc
     8821 taaccattac aaagaccatt aaccgtttag gtacagtctt cttcctattt gtcttcaata
     8881 ttgggatttc catatttgta ttcctattaa caggaatcat gattttctcg caggtacttt
     8941 ttatcatcta tgctatgttt ctgcctgtga gctttatttt aagcatgatt ccatcatttg
     9001 atggtatgtc aaaacgagcc ataacaaagc tctttaatac cattttgaca cgagctggaa
     9061 tcacattgat tattacgaca gcatttagta tttcaaccat gctctatacc ttatcggctg
     9121 gttatccgtt ctttttgatt gcttttctac agattgtgac ctttgcagga atctacttca
     9181 agctgggcga tttaatgagt atgttttctc tacagagtaa cgattctcaa agtgtgggaa
     9241 gtcgtgtgat gagaaaacct cgtatgctta tgcacgctca catgcaccgt ctacagcgga
     9301 aacttggacg ttccatgact actctagggg ctgggtctgc cattgttaca ggtaaaaaag
     9361 gacagtcggg ttcggggagt tctgcaagga cacaagcaga tcactcccga ccagacggaa
     9421 aggaaaaatc aacacttgga aaacgtatcg gtcaaaccat cggtacagta gctgatacca
     9481 aagacagaat ggtagacact gctagtggtt tgaaagaaca ggttaaagat ttgccgacca
     9541 atgcaagata tgcagtatat caaggaaaat ccaaagtaaa agagaatgtc cgtgatttaa
     9601 ccagtagtat ttctcaaacc aaagcggaca gagccagtgg acgcaaggaa cagcaggaac
     9661 aaaggcgaaa aaccattgcg aagcgtcgct ctgaaatgga acaggtcaaa cagaaaaaac
     9721 agcctgcttc ttctgttcat gaaagaccga ctacaagaca agaacaatat catgatgaac
     9781 agacctcaaa acagtctaat attcagactt catataagga atctcaacaa gccaaacaag
     9841 agcgtccagc agttaagtcc gatttttcaa gtccaaaagt ggaacgccaa ggcaataccg
     9901 ttcaagaaaa aaccgttcaa aagccagcaa cttcaaccac tacagcagat agaacttcac
     9961 aacgtccaat cacaaaagaa cgtccgtcta ctgttcaaag agtaccacta caaaatacaa
    10021 gaagtagacc accaatcaaa accgccacca ttaagaaagt cggtaagaaa ccatgaagtt
    10081 gaaaacttta gtgattggtg gttctggatt attcttgatg gtcttctcac tgcttctgtt
    10141 tgttgccatt ttattttcag atgaacagga cagcggaatt tccaatattc attatggagg
    10201 tgtgaatgtt tccgcagaag tgctggctca taagcctatg gtagaaaaat atgccaaaga
    10261 atatggcgtt gaagaatatg tcaacatact tcttgcgatt atacaggtgg aatcgggcgg
    10321 tactgcggaa gatgttatgc agtcctcgga atccctcggt cttccaccta attcattgag
    10381 tacagaagaa tccattaagc aaggtgtgaa gtatttcagt gaattattag ccagtagcga
    10441 aaggctcagt gtagatttag aatcggttat ccagtcctac aattatggtg gtggtttctt
    10501 agggtatgtg gctaatcgtg gaaataaata tacctttgaa ctggctcaaa gtttctcaaa
    10561 agagtattca ggtggcgaaa aagtgtctta ccccaatccc atagccatac ctatcaatgg
    10621 gggctggcga tacaactatg gcaatatgtt ttatgtgcaa ctggtaacgc agtatcttgt
    10681 cacaacagag tttgatgatg atacggtaca agccatcatg gacgaagcac tgaaatatga
    10741 gggctggcga tacgtttacg gtggagcttc cccgactact tcttttgatt gtagcggact
    10801 gacacaatgg acgtatggaa aagctggaat taacttacca cgaaccgcac aacagcaata
    10861 tgatgtgacc cagcatatcc cactatcgga agcacaagct ggcgatttgg ttttctttca
    10921 ttctacctat aacgctggct cttatattac tcatgttggg atataccttg gcaataaccg
    10981 tatgtttcat gcaggcgacc caatcggtta tgccgactta acaagcccct actggcaaca
    11041 gcatttagtg ggagcaggac gaatcaaaca atgagaaagg aagatttaat gatgaaattt
    11101 agaaaaaatc agaataaaga aaaacagata ccaaaggaaa agaaacctcg tgtctataag
    11161 gtcaatcctc ataaaaaggt tgtgattgcc ttgtgggtac ttttagggct tagtttcagc
    11221 tttgcgatat tcaagcactt tacagctata gatactcata ctattcacga aacaactatc
    11281 atagaaaagg aatacgttga tactcatcat gtagaaaatt ttgtagagaa ctttgcgaaa
    11341 gtctactatt catgggagca atccgataag tccattgata atcgaatgga aagtctaaaa
    11401 ggctatctga cagatgaact tcaagctctc aatgttgata cagtacgcaa agatattcct
    11461 gtatcgtctt ctgtaagagg atttcagata tggacggtag agccaactgg cgacaatgag
    11521 tttaatgtaa cctacagtgt agaccagctc attacagagg gagaaaatac aaagaccgtc
    11581 cactctgctt atatagtgag tgtctatgta gatggttctg gaaatatggt actggttaag
    11641 aatccgacca ttaccaacat acctaagaaa tcaagttata aaccaaaagc cattgaaagt
    11701 gaggggacgg ttgattccat tacaaccaat gaaatcaatg agtttttaac gacgttcttc
    11761 aagctctatc ctacagcgac agccagtgaa ctttcctact atgtgaatga cgggatatta
    11821 aaaccaatcg gaaaagagta catctttcaa gaactggtaa atcctattca caatcgtaag
    11881 gataatcaag tcacggtatc gctgacagtg gagtatatcg accagcagac caaagcaacg
    11941 caggtatctc aatttgattt ggtacttgaa aagaacggga gtaattggaa gattatagaa
    12001 taacaaatat tggtacatta ttacagctat tttgtaatca cgtactctct ttgataaaaa
    12061 attggagatt cctttacaaa tatgctctta cgtgctatta tttaagtatc tatttaaaag
    12121 gagttaataa atatgcggca aggtattctt aaataaactg tcaatttgat agtgcgaaca
    12181 aataattgga tgtccttttt taggagggct tagttttttg tacccagttt aagaatacct
    12241 ttatcatgtg attctaaagt atccggagaa tatctgtatg ctttttatgc ccttttgggc
    12301 ttttgaatgg aggaaaatca catgaaaatt attaatattg gagttttagc tcatgttgat
    12361 gcgggaaaaa ctaccttaac agaaagctta ttatataaca gtggagcgat tacagaatta
    12421 ggaagcgtgg acaaaggtac aacgaggacg gataatacgc ttttagaacg tcagagagga
    12481 attacaattc agacaggaat aacctctttt cagtgggaaa atacgaaggt gaacatcata
    12541 gacacgccag gacatatgga tttcttagca gaagtatatc gttcattatc agttttagat
    12601 ggggcaattc tactgatttc tgcaaaagat ggcgtacaag cacaaactcg tatattattt
    12661 catgcactta ggaaaatggg gattcccaca atctttttta tcaataagat tgaccaaaat
    12721 ggaattgatt tatcaacggt ttatcaggat attaaagaga aactttctgc cgaaattgta
    12781 atcaaacaga aggtagaact gtatcctaat atgtgtgtga cgaactttac cgaatctgaa
    12841 caatgggata cggtaataga gggaaacgat gaccttttag agaaatatat gtccggtaaa
    12901 tcattagaag cattggaact cgaacaagag gaaagcataa gatttcataa ttgttccctg
    12961 ttccctgttt atcacggaag tgcaaaaaac aatataggga ttgataacct tatagaagtg
    13021 attacgaata aattttattc atcaacacat cgaggtcagt ctgaactttg cggaaaagtt
    13081 ttcaaaattg agtattcgga aaaaagacag cgtcttgcat atatacgtct ttatagtggc
    13141 gtactgcatt tgcgagattc ggttagaata tcggaaaagg aaaaaataaa aattacagaa
    13201 atgtatactt caataaatgg tgaattatgt aaaatcgata aggcttattc cggggaaatt
    13261 gttattttgc agaatgagtt tttgaagtta aatagtgttc ttggagatac aaagctattg
    13321 ccacagagag agagaattga aaatcccctc cctctgctgc aaacgactgt tgaaccgagc
    13381 aaacctcaac aaagggaaat gttacttgat gcacttttag aaatctccga cagtgacccg
    13441 cttctgcgat attatgtgga ttctgcgaca catgaaatca tactttcttt cttagggaaa
    13501 gtacaaatgg aagtgacttg tgctctgctg caagaaaagt atcatgtgga gatagaaata
    13561 aaagagccta cagtcattta tatggaaaga ccgttaaaaa aagcagagta taccattcac
    13621 atcgaagttc caccgaatcc tttctgggct tccattggtt tatctgtatc accgcttccg
    13681 ttgggaagtg gaatgcagta tgagagctcg gtttctcttg gatacttaaa tcaatcattt
    13741 caaaatgcag ttatggaagg gatacgctat ggctgtgaac aaggattgta tggttggaat
    13801 gtgacggact gtaaaatctg ttttaagtat ggcttatact atagccctgt tagtacccca
    13861 gcagattttc ggatgcttgc tcctattgta ttggaacaag tcttaaaaaa agctggaaca
    13921 gaattgttag agccatatct tagttttaaa atttatgcgc cacaggaata tctttcacga
    13981 gcatacaccg atgctcctaa atattgtgcg aacatcgtag acactcaatt gaaaaataat
    14041 gaggtcattc ttagtggaga aatccctgct cggtgtattc aagaatatcg tagtgattta
    14101 actttcttta caaatggacg tagtgtttgt ttaacagagt taaaagggta ccatgttact
    14161 accggtgaac ctgtttgcca gccccgtcgt ccaaatagtc ggatagataa agtacgatat
    14221 atgttcaata aaataactta gtgtatttta tgttgttata taaatatggt ttcttgttaa
    14281 ataagatgaa atatttttta ataaagattt gaattaaagt gtaaaggagg agatagttat
    14341 tataaactac aagtggatat tgtgtgctga gagctttctt ctatactaat agacgaaagg
    14401 gtgtgaaaat gatttttaaa tgatactgtg gaacggaaca gtagccctag tattgactac
    14461 tgtcgtttct attcatattg gctattctag gactgagatg aaaaaatcta taaatgctca
    14521 gaataaaatt gaacccgcaa atctccccaa aacaatggtg agtcatgtac ttgtattatt
    14581 ccgaaaaaat acacctctgg tgcagtgaga caaattggtg tatcttatag tggcttcgta
    14641 gatgaaagct atactctact atcactcttt gatgatgtag aacaaattga aaaagataat
    14701 agacttcaga cagctattga tgttgtcaga gaacagtttg gttttttagc catacaaaaa
    14761 ggaaccgtcc taactgaagg ttccagaaat attgaacgca gtaaacttat cggtggtcat
    14821 tccgcgggtg gattggaggg attaaaatga aacaagaaaa aaatacagta caattttcag
    14881 aaatccgtag caaaggatgt aatgatattg aaatgcttga aagattttta catggaatcg
    14941 ttgaaacagc aacttcaaaa cttcgtcaga gaaaactcaa aacaactgaa atatcgatac
    15001 gactagtaca tgctaaatct gaaaaccgat taccattgga atttacattt agcattaagc
    15061 caacaagctc atctgtgata atctatactg aggtaatcaa tcgctttaaa gaatgttaca
    15121 caggtggggg aattcaaggt tttacgattc aatttgataa aaataccctt gcctctgcat
    15181 agaaaggatt tgatatgatt gaccgttcat atttaccatt tcaatcagca agagagtacc
    15241 aggatacaaa gatgcaaaaa tggatgggct ttttcctatc tgaacatgca tcagcactct
    15301 ctgatgatac aaacaaagta acgtacatgt ctgacttatc actagagaag aaattattac
    15361 tcctcagtca agtatacgcc gggcagctac gcacacgcat tcaagtgatt gaaaaaaaca
    15421 agcgtgtttc ctacactgga acaataccaa gtctgaccaa agatttcatt ttgataaaaa
    15481 ctacaacagg tcacatcaat ttgaaattaa aagacattat tagtattgaa cttgtcgagg
    15541 aggtgctcta tgaatcagct tgagtttcag cgtaatcacc tacaaatgga ctattatagc
    15601 gagagctacc aagattttga acgtgacttc taccgctact ctaacatgaa tattccattg
    15661 accttcctaa ctgatgatat cctaaaaaca atggcgactt cacgtaagaa ttactttgtc
    15721 ctcaataagg aaaagtccag agataaccgc gatcacttct tcatatttga agtaagtacc
    15781 gtagatgaga atccgctaat ctatcattat acatataaga aaactacaat atatttagca
    15841 gaaaaatagg agcagttcaa ttgactgttc ctatttttaa tattcataaa atctaaagtc
    15901 tttatactct ttaacaatgg agtcgccaac cagaacagac tatactgacc agcgactacc
    15961 ttaaatttaa tgtttcagat ttattttctt atctctaatt tcataaacta catctgctac
    16021 attttcgagt aatcgtttat cgtgggtgat aaacacgata gttccggtgt actccttcat
    16081 tagtatttcc aaagcctcta aacttggtat gtcaaggaag ttactgggtt catccattat
    16141 taggatgtta tatctaccca tgagcatttt agcaagcaac aattttataa tttctccacc
    16201 gcttaaaaca gataaacttt ttccaatatc gttctgtttg aaccccatag atgctagcac
    16261 tgaacgaatt tctgatatat tgtagtcaca atccttctgc ataaactcca taacattctg
    16321 attactgttg tacttgtaac cattctgtgc aaagtaacct atttttgcct taggcgaaat
    16381 agaaattcct tcttcatggt ttaagatcat ttggattaaa gttgtttttc cgattccatt
    16441 accaccagtt aacgccactt ttgctcctaa cggaatttga aaagatgcat tttcaaacag
    16501 agccttatcc ccaaatactt tattaatttc tgcaccgact atagggtatg gattatggag
    16561 ctccaatgct ttactttgcc tgaaacgaat tctgcgaatg ccttccggag cttctacttt
    16621 tcctaaggcc gcaatcctgt gctctagggt tttagcagca ttatacatct ttttttcctt
    16681 acttcctatt gatttttgat gagctaaacg ccctccgtct tcagtacttt ttttctttga
    16741 agaacctttt gccttctgtt ctattttacg agcctgtttt cgcttttcct ccgcagccct
    16801 ttccaatcgg gcacgttccg caataaattg ttcgtattct gcagcttggc tcttacgttc
    16861 ttcctctttc tgacgaagat aatcagaata gtttccccaa tactcagtga ttttgccatc
    16921 tttcagttcc catattttat ctactatttc atcaagaaaa tagcggtcat ggctaataac
    16981 taacagtgca cctgtaaaat attttagctg tcctattaga aaatcaattc cttcacggtc
    17041 taaatggctc gtaggttcat ccgctaaaat accatgaacc tgtgccgata aggcctgtgc
    17101 tattttaagc cttgtttctt caccaccgct catagtctgt atatttaatt gctcaacacc
    17161 tagcttgcct acaagtgcaa aatctttttc ctcctgcaga gttacttcgt ccaactgggg
    17221 aatataggca agttcaccca gacgattcat tttacatcct gggggagtta attctcctaa
    17281 aagtaccctg agtaaagtgc tttttccagc accatttgct cctactaaac caatacggtc
    17341 ataatcatat acttctaatt catttatatc taaaacatcg cgtcctttga attccacacg
    17401 aatgtctttt gcttttaata ttaattccat aacatttcct cctgtctata atcgcatgct
    17461 ttcatttgct tgtatgcagg gaaaaccctg cgattttagc aggaagagtt acatgaaaat
    17521 aagatacata aatattcctc caatattgtt tattttaaat ctaattttct aacctcagtt
    17581 atcatttggc aaactatagc aatgccaata attaaaatac ctgatagtaa aaaccaatga
    17641 tttacaccga ttttatcagc aaagaatcca gaaagaatta acccaattgg catagcaagt
    17701 gacatgatac ttccgatcaa agaaaataca cgtcctaaat attcaggctt aattttctcc
    17761 tgaaaaagag ctgtttgcac accgctataa aatggcaccg aaagccccat tattgcacag
    17821 caaactacga atattacaaa tccatttgga ggaagtattc ccgaaacggc taaactggtc
    17881 cccattataa aaaatgaact tgttattagt aatacatgct tttcgaagcc ccctaatctt
    17941 cctaataata agcctcctgc tagcatccca aatgcaaagg aaatttccgt aatagaaata
    18001 tgcacaggcg ttccattaaa gtgttccatg cttattaaag gaaatagtgc attgattggc
    18061 atataaacaa aagtatatag tgttcctaag agtaataagg caaacaatcc tttgttttgt
    18121 ctcagaacca caactccttc tttcatctcc cttatgaaat ttggttctaa actttgcact
    18181 tgattaccca gcttaggtat acgtacaatt gctaccgtaa tagatgcaat cacagcaccc
    18241 aatacgtcga tggcaataat agcatttaaa tcccaaacgg agtataagag tgctgcaact
    18301 gccggactaa caatatagct tatagactgc aaagactgac tatagcctgc gcatttcgtt
    18361 agctgttctt ctggtactaa aagtggtgta accgcattga gtgctggggt atgaaaagct
    18421 gttccaatgc tacggataaa caatactatc ataatcatcc agacaggtag ctccatacag
    18481 aatgcaacaa tagcaagcac tgcaccagct gctgcgataa ttaaatcggc accaatcatt
    18541 atcttcttcc tatcatgacg atccactagc acaccaatgg caggtcccaa aatcgcatag
    18601 ggtaaaaaac ctactaatga agccatagac aagaccatcg cagatcctgt tttttctgta
    18661 aggtaaaaaa taatcgccat ttgcaggatg gcactagtga ttaatgatac tgcttgccct
    18721 gcccatattg cataaaattt tcgtttccaa ttgttgtatt tttccattta tattatctcc
    18781 tgcatattat tttgcttgaa tttctatttt gaatagcatt ctaggcaata aaaaatgcag
    18841 gccaaacccc acaatgtggc ttttggtctg catacataca atttggaaac attcatatta
    18901 aagacatagt taaataaagg tatagttaaa taaccaatat cctcaccgta actaatgaat
    18961 gctcaatatc gtataaataa gcacaacaaa aaagcctatc atcgggtata gattctgctt
    19021 tttttattgc cagcttatct taaacgcatt gaggctgtca tagtttcggt tcctcctaca
    19081 tctttgttta tatcaattta tagtataaca caacaagatg atatgttcaa tataaaagtt
    19141 atggaatgag actcatactt ccaattcgat gccagattta aaggatatga cgaagttttc
    19201 ttcatagact gtaacgctct ggattatctt ccttagtagc aagcgattag ctttcacaaa
    19261 atcttctgtt tgtagtttta aaaattcatc aggattttct aactcaacct caaaatattt
    19321 cattttacat tccctcattt catttattga taaattgagt ttgcaaaaaa gagtggacaa
    19381 tttttgtcta ctcttaacct ttaaaatagt tttttttaat cgatttgaag ttgcctaaat
    19441 tattacttat tcggtaaaat gaagtattgc tttcaacaga tttccttcaa ctacacttca
    19501 cttgattcaa acaaggtggg tacatttcta ttcccacaaa ctccttgtca atggaaacaa
    19561 acacgtaccc acagggtaaa tggaaataga aactgataat ttctagctat cacttctact
    19621 cattccaaaa attttctcac tctgatactt acccaccata aagcaaaaag ccttgcaatc
    19681 aaggctttca ttatcccttt cgttcaaagg tttctaagct tttacgagca gagcgacaca
    19741 ctcagcggtt cgctatctcc gttctgtctg cgtgctagca cttgtcaatc acggacagct
    19801 atcgcatggg cggaagtaaa tgctaatctt cgtcgtttta ctccttgact agcaaactta
    19861 ccgcctcaac atgtcctgta tgtggaaata aaacacgatt aaagataagg gaagatactg
    19921 aattaaaaaa attccccctc tattgtccga aatgcagaca agaaaattta attgaaataa
    19981 agcagttcaa agtaactgtg attacagagc cagacgcaaa gacgcagagc cgataaaatg
    20041 agattaatac aatctcattt tatcggctct ttccgttatg tatggattct tttaattagt
    20101 cttcgatgtt tcttgcttcg ttgataccgc tggctaaaga ttccattaag gatagttctt
    20161 tgtctgtaaa gctatccatg tatttctcta tctgtaatcg tcgggtgctt tttaccaagt
    20221 tattagcagg taagaaaaat tcatcaacgg aaacatgaag taacgataca aggtcataaa
    20281 gaacttgtat gctggggtgt tgccctttat tttcaatatt agttaagtac cgtgggtcaa
    20341 tttcaatcaa tgctcccact tgttcacgag ttaaacctcg tttcaatcga gcttctttaa
    20401 tggctaaacc aaaggctcta aaatcatatt tatcttcttt tttacgcata gtagaccacc
    20461 tctatacatt ttattgttcc tactgaatta aaaacaggta tagaaaaacg tgttatatgg
    20521 tttataggtt tatatttaat aaaaagcact actaaacgcc aataaaaaaa accgttatat
    20581 ggtagtgcta tttacgctgt taaaatattg tatattactt ccaaatggcg gtttgttgga
    20641 ggtcaacgtc gccatgaagt acatcatata caataaattt ccttacattg ggttcttgtc
    20701 aaaaaaagtc gtctatctgc aatagataag tacgtccacc aatgtggttt tataaatcat
    20761 atagatagaa taacagaagc atgtaaacag agaaataaat ctgtttatat gcttttttgg
    20821 ctattcagaa cttttttaca aagtttattt atcagtaatg caacaaatcc ccctttcaca
    20881 ttgggactaa gagtgaaagg agataaacga gcaaggctca cttcctttcc tagacagaaa
    20941 gggggtgaga aacatgaaac catcttcttt tcagaccaca atagaaaatc agtttgacta
    21001 tatctgtaaa cgtgctatgg aagacgagcg aaagaattat atgctttatc tttcaaggat
    21061 tgcaaagcgt gaggtgtcct tttcggatgt tggcgattat cttgttagcc agtttgcgac
    21121 aacagataac tattcaactg actttcagat ttttacactc aatgggttat cagtaggcgt
    21181 tgaaaatgat ttgttgagtg aagcattacg tgagttgcca gacaagaaac gtgaaattct
    21241 actgctgttt tactttatgg acatgagcga ttcagaaatt gcagacctgt tgaaattgaa
    21301 ccgttctact gtctatcggc atagaaccag tggactagcc ttaattaaaa agtttatgga
    21361 ggaatttgaa gaatgaaaac acaatatcct atgattccct ttcctctcat tgtaaaggca
    21421 acagatggcg ataccgaagc gattaaccag attctacatc attacagagg gtacataacg
    21481 aagcgttccc tacgacttat gaaagatgaa tatggcaatc aaagtatggt cgttgatgaa
    21541 gtcttacgtg gaagaatgga aaccagactg attacaaaga ttttgtcatt tgaaattaag
    21601 taatatcctc tctcctttcg tggaagcgtg ctaaaccatt ccacgcttcc cgaacaggga
    21661 ggtttgttat tccaccaaag catattgagc tttcaatgtg ttttgatagg ctaacgagcc
    21721 attgttcttt gaaaactgaa taaaagtaat cgaatacgtt tcgataagaa aagagccaac
    21781 ggaactaacc gccatgacct atcttataaa gatagcgagc gattcatgtt agtgatccga
    21841 gaagcaatct ttagcaggat tgcctgcaac gacattctta tcgtgataat gatactccca
    21901 tacagtcaat agtccgagcg tgataaaacc gtcgcaggca atgagtatgg ctacatgaga
    21961 accatgcagg ggtggaactc ccgtgagctt tgctaaagct gttcgattgc tggtaaaaca
    22021 acttttatga aatccaaata agtgatttgg aaaggaggat tttatgaagc agactgacat
    22081 tcctatttgg gaacgttata ccctaaccat tgaagaagcg tcaaaatatt ttcgtattgg
    22141 cgaaaacaag ctacgacgct tggcagagga aaataaaaat gcaaattggc tgattatgaa
    22201 tggcaatcgt attcagatta aacgaaaaca atttgaaaaa attatagata cattggacgc
    22261 aatctagcgt cgccaaaggg tcttgtatat gataaaatag tattaagtcg tatcaaggct
    22321 ctttccataa aggaaaggag caaatgccat gtcagaaaaa agacgtgaca ataaaggtcg
    22381 aatcttaaag actggagaga gccaacgaaa agacggaaga tacttataca aatatataga
    22441 ttcatttgga gaaccgcaat ttgtttactc gtggaaactt gtggctacag accgagtacc
    22501 agcaggaaag cgtgattgta tctcacttag agagaaaatc gcagagttac agaaagacat
    22561 tcatgatggt attgatgttg taggaaagaa aatgacactc tgccagcttt acgcaaaaca
    22621 gaacgctcaa agaccaaagg ttagaaaaaa cactgaaact ggacgcaaat atcttatgga
    22681 tattttgaag aaagacaagt taggtgtaag aagtattgac agtattaagc catcagacgc
    22741 taaagaatgg gctattagaa tgagtgaaaa tggttatgct tatcaaacca tcaataacta
    22801 caaacgttct ttaaaggctt cattctatat tgctatacaa gatgattgtg ttcggaagaa
    22861 tccatttgac tttcaactga aagcagttct tgatgatgat actgtcccta agaccgtact
    22921 aacagaagaa caggaagaaa aactgttagc ctttgcaaaa gctgataaaa cctacagcaa
    22981 aaattatgat gaaattctga tactcttaaa aacaggtctt cgtatttcag agtttggtgg
    23041 tttgacactt ccagatttag attttgagaa tcgtcttgtc aatatagacc atcagctatt
    23101 gagagatact gaaattgggt actacattga aacaccaaag accaaaagtg gcgaacgtca
    23161 agttcctatg gttgaagaag cctatcaagc atttaagcga gtgttagcga atcgaaagaa
    23221 tgataagcgt gttgagattg atggatatag tgatttcctc tttcttaata gaaagaacta
    23281 tccaaaagtg gcaagtgatt acaacggcat gatgaaaggt cttgttaaga aatacaataa
    23341 gtataacgag gataaattgc cacacatcac tccacatagt ttgcgacata cattctgtac
    23401 caactatgca aatgcaggaa tgaatccaaa ggcattacag tacattatgg gacatgctaa
    23461 tatagccatg acgctgaact attacgcaca tgcaacattc gattctgcaa tggcagaaat
    23521 gaaacgcttg aataaagaga agcaacagga gcgtcttgtt gcttagtagt acaaatgaat
    23581 ttactactta tttaccactt ctgacagcta agacatgagg aaatatgcaa agaaacgtga
    23641 agtatcttcc tacagtaaaa atactcgaaa gcacatagaa taaggcttta cgagcattta
    23701 agaaaatata aaaagataat tagaaattta tactttgttt attttaaaga agtgattcta
    23761 atgtacaagg gtgtaatttg ttagaatttc aaaaatttag agcatttttg gctt
//
